PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2513186-8	1989	As a characteristic feature, part of the triantennary glycans at Asn184 and Asn448 contain additional Gal(alpha 1-3) substituents and/or sulfate groups linked to position six of beta-galactosyl residues forming NeuAc(alpha 2-3)[HO3S-6]Gal(beta 1-4) units.	N-Acetylneuraminic Acid	211-216	hemoglobin, beta adult major chain	Mus musculus	239-247
2513186-9	1989	Oligosaccharides attached to Asn448 are almost completely substituted by (alpha 2-3)- or (alpha 2-6)-linked sialic acid residues and carry the majority of sulfate groups present.	N-Acetylneuraminic Acid	108-119	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	90-99
2584211-5	1989	We now report a highly specific interaction between gangliotriaosylceramide (Gg3, GalNAc beta 1----4Gal beta 1----4Glc beta 1----Cer) and sialosyllactosylceramide (GM3, NeuAc alpha 2----3Gal beta 1----4Glc beta 1----Cer).	N-Acetylneuraminic Acid	169-174	granulocyte macrophage antigen 3	Mus musculus	164-167
2481486-7	1989	It is possible that the common epitope shared by GD2 ganglioside and NCAM involves sialic acid residues common to both the ganglioside and the glycoprotein.	N-Acetylneuraminic Acid	83-94	neural cell adhesion molecule 1	Mus musculus	69-73
2517477-5	1989	Sialic acid content in milk biotinidase was less than that found in serum enzyme.	N-Acetylneuraminic Acid	0-11	biotinidase	Homo sapiens	28-39
2819088-5	1989	The importance of the sialic acid content to the stabilization activity of glycophorin was further confirmed by the observation that the neuraminidase-treated type MM showed a lower stabilization activity than the untreated type.	N-Acetylneuraminic Acid	22-33	neuraminidase 1	Homo sapiens	137-150
2553807-4	1989	Neuraminidase digestion before EC adhesion increased the binding efficiency of all lymphocyte subsets, although the relative increase in each subset was proportional to the initial LFA-1 sialic acid content.	N-Acetylneuraminic Acid	187-198	integrin subunit alpha L	Homo sapiens	181-186
2627120-2	1989	Inhibition by retinol acetate of cell invasive potential was accompanied by a significant decrease in the enzyme activity of intact cells as well as total and cell surface neuraminidase-releasable sialic acid contents.	N-Acetylneuraminic Acid	197-208	neuraminidase 1	Homo sapiens	172-185
2477227-11	1989	We propose that the N-linked oligosaccharides on beta-core closely resemble the underlying N-linked structures of hCG beta with the antennary sialic acid, galactose, and N-acetylglucosamine removed.	N-Acetylneuraminic Acid	142-153	chorionic gonadotropin subunit beta 3	Homo sapiens	114-122
2614277-2	1989	The sugar moiety of apoC-III is attached to amino acid residue 74 and is thought to consist of 1 mole of galactose, 1 mole of N-acetyl-galactosamine, and either 0, 1, or 2 moles of sialic acid.	N-Acetylneuraminic Acid	181-192	apolipoprotein C3	Homo sapiens	20-28
2479564-0	1989	The restrictive role of sialic acid in antigen presentation to a subset of human peripheral CD4+ T lymphocytes that requires antigen-presenting dendritic cells.	N-Acetylneuraminic Acid	24-35	CD4 molecule	Homo sapiens	92-95
2592487-3	1989	The pattern changed when iron-free transferrin was treated with neuraminidase, which splits off the sialic acid from the carbohydrate chains.	N-Acetylneuraminic Acid	100-111	transferrin	Homo sapiens	35-46
2592487-3	1989	The pattern changed when iron-free transferrin was treated with neuraminidase, which splits off the sialic acid from the carbohydrate chains.	N-Acetylneuraminic Acid	100-111	neuraminidase 1	Homo sapiens	64-77
2482250-3	1989	When CD46 molecules (mol.wt = 66 and 56 kDa) from human thymocytes were stripped of sialic acid with neuraminidase, or stripped of N-linked carbohydrate with endoglycosidase F, the E4.3 MoAb was still able to bind and immunoprecipitate the protein core of CD46 (mol.wt = 56 and 44 kDa).	N-Acetylneuraminic Acid	84-95	CD46 molecule	Homo sapiens	5-9
2682204-5	1989	[125I]IMAB-labeled brain and parathyroid D1 receptors were sensitive to treatment with the exoglycosidases neuraminidase or alpha-mannosidase, suggestive of the existence of terminal sialic acid and oligomannose residues.	N-Acetylneuraminic Acid	183-194	neuraminidase 1	Bos taurus	107-120
2510824-1	1989	This paper presents kinetic properties of the transfer of several synthetic 9-substituted sialic acid analogues onto N- or O-linked glycoprotein glycans by four purified mammalian sialyltransferases: Gal beta 1,4GlcNac alpha 2,6sialyltransferase, Gal beta-1,4(3)GlcNAc alpha 2,3-sialyltransferase, Gal beta 1,3GalNAc alpha 2,3sialyltransferase, and GalNAc alpha 2,6sialyltransferase.	N-Acetylneuraminic Acid	90-101	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	298-343
2549051-0	1989	Fibrinogen sialic acid residues are low affinity calcium-binding sites that influence fibrin assembly.	N-Acetylneuraminic Acid	11-22	fibrinogen beta chain	Homo sapiens	0-10
2768266-4	1989	Differential centrifugation, as well as density gradient analysis using 25% Percoll, showed that the stored NeuAc cosedimented with the lysosomal enzyme beta-hexosaminidase.	N-Acetylneuraminic Acid	108-113	O-GlcNAcase	Homo sapiens	153-172
2549051-4	1989	In this study, we show that removal of fibrinogen sialic acid residues results in loss of low affinity Ca2+-binding sites.	N-Acetylneuraminic Acid	50-61	fibrinogen beta chain	Homo sapiens	39-49
2510824-2	1989	The substituents at C-9 of the sialic acid analogues introduce special biochemical characteristics: 9-Amino-NeuAc represents, up to the present, the first derivative that is resistant toward bacterial, viral, and mammalian sialidases but is transferred by a sialyltransferase.	N-Acetylneuraminic Acid	31-42	complement C9	Homo sapiens	20-23
2549051-7	1989	These observations suggest that the high affinity fibrinogen D-domain Ca2+-binding sites may play a role in the tertiary structure of the D-domain, whereas, sialic acid residues are low affinity sites whose occupancy by Ca2+ at physiological calcium concentration facilitates fibrin polymerization.	N-Acetylneuraminic Acid	157-168	fibrinogen beta chain	Homo sapiens	50-60
2473124-11	1989	The removal of sialic acid residues by neuraminidase treatment facilitated the detection of the allodeterminants by anti-H-2Dd-specific mAb and CTL.	N-Acetylneuraminic Acid	15-26	neuraminidase 1	Homo sapiens	39-52
2804449-4	1989	Treatment with neuraminidase to remove sialic acid residues reduced their size slightly, but did not diminish the difference in Mr between the two species.	N-Acetylneuraminic Acid	39-50	neuraminidase 1	Homo sapiens	15-28
2475575-6	1989	The immunoregulating isomer termed AFP-1 was the least acidic of the seven isolated variants with a pI of 5.1 and displayed a sialic acid content of 1 mol/mol of protein.	N-Acetylneuraminic Acid	126-137	alpha fetoprotein	Homo sapiens	35-38
2547792-9	1989	These results indicate that the labeled 45-kDa glycoprotein contains terminal sialic acid residues, explaining the low pI of this protein, and that it is characteristic for melanoma cells and hence part of the MSH receptor.	N-Acetylneuraminic Acid	78-89	msh homeobox 1	Mus musculus	210-213
2590468-9	1989	The antigens of BRIC4 and APO1 were found to be located within the residues 2-21 and to comprise sialic acid attached to O-glycosidically linked oligosaccharide(s).	N-Acetylneuraminic Acid	97-108	Fas cell surface death receptor	Homo sapiens	26-30
2546635-1	1989	Recombinant human erythropoietin labeled covalently with biotin at sialic acid moieties has been prepared, and has been shown to possess high biological activity plus utility as a receptor ligand.	N-Acetylneuraminic Acid	67-78	erythropoietin	Homo sapiens	18-32
2546635-5	1989	Biotinylation at sialic acid moieties using periodate and biotinamidocaproyl hydrazide proceeded efficiently (greater than 95% and 80% labeling efficiencies for human urinary and recombinant erythropoietin, respectively) and yielded stably biotinylated erythropoietin molecules possessing comparably high biological activity (ie, 45% of the activity of unmodified hormone).	N-Acetylneuraminic Acid	17-28	erythropoietin	Homo sapiens	191-205
2554755-8	1989	Moreover, because this technique was used successfully in the immobilization of periodic acid--Schiff positive staining glycoprotein 1 prepared from human erythrocytes and human alpha 2-macroglobulin, the technique should also be useful for other membrane or secreted proteins that possess N-linked sugar chains containing bisecting N-acetylglucosamine or a high amount of sialic acid.	N-Acetylneuraminic Acid	373-384	alpha-2-macroglobulin	Homo sapiens	178-199
2478876-11	1989	Subsequent to saponification, neuraminidase cleaved most of the sialic acid from the mucins.	N-Acetylneuraminic Acid	64-75	neuraminidase 1	Homo sapiens	30-43
2478876-15	1989	It should be noted that jejunal mucin and bovine submaxillary mucin also contain O-acetylated sialic acid, but did not inhibit in our radioimmunoassay.	N-Acetylneuraminic Acid	94-105	mucin 1, cell surface associated	Bos taurus	32-37
2478876-15	1989	It should be noted that jejunal mucin and bovine submaxillary mucin also contain O-acetylated sialic acid, but did not inhibit in our radioimmunoassay.	N-Acetylneuraminic Acid	94-105	mucin 1, cell surface associated	Bos taurus	62-67
2478876-17	1989	Analyses of the partially methylated alditol acetate derivatives by gas chromatography-mass spectrometry of the untreated, as well as the saponified and neuraminidase treated, mucins revealed that sialic acid was attached to the carbohydrate core either to galactose, N-acetylglucosamine, and/or N-acetylgalactosamine.	N-Acetylneuraminic Acid	197-208	neuraminidase 1	Homo sapiens	153-166
2476036-8	1989	It contained 22.2 mg of sugar per 100 mg protein, and sialic acid at least expressed the activity of the epitope because the antigenic activity was decreased by neuraminidase treatment.	N-Acetylneuraminic Acid	54-65	neuraminidase 1	Homo sapiens	161-174
2745406-5	1989	The results revealed: 1) an identical response in binding activity and sialic acid content in cells subjected to minimal exposure to neuraminidase; 2) a parallel and synchronous recovery of both parameters following modulation; 3) an invariant binding of high affinity ligands, and 4) the ability of galactose oxidase to restore, at least partially, the cell"s ability to bind asialoglycoprotein.	N-Acetylneuraminic Acid	71-82	neuraminidase 2	Homo sapiens	133-149
2721445-3	1989	Enzymatic deglycosylation of hTeBG with neuraminidase to remove sialic acid led to the production of two subunits of 50,800 and 47,300 Mr when assessed by SDS-PAGE.	N-Acetylneuraminic Acid	64-75	sex hormone binding globulin	Homo sapiens	29-34
2775488-0	1989	Isolation and structural characterization of sialic-acid-containing glycopeptides of the O-glycosidic type from the urine of two patients with an hereditary deficiency in alpha-N-acetylgalactosaminidase activity.	N-Acetylneuraminic Acid	45-56	alpha-N-acetylgalactosaminidase	Homo sapiens	171-202
2778161-5	1989	The ratio of fucose, mannose, galactose, N-acetylgalactosamine, N-acetylglucosamine, and sialic acid of lactophorin, which contains about 18% saccharide, were 1, 6.6, 10.3, 5.5, 9.7, and 11.6, respectively, while the respective ratio of the seven components were 1, 5 to 6, 7 to 9, 3 to 4, 6 to 8, and 4 to 12.	N-Acetylneuraminic Acid	89-100	glycosylation dependent cell adhesion molecule 1	Bos taurus	104-115
2502333-4	1989	First, sialic acid residues were removed by treatment of the acid phosphatase with neuraminidase.	N-Acetylneuraminic Acid	7-18	neuraminidase 1	Homo sapiens	83-96
2498327-11	1989	ApoE sialylation was dependent on the addition of galactose as well as GalNAc to the extracellular medium, suggesting that addition of galactose to the nascent oligosaccharide chains was required for the addition of sialic acid.	N-Acetylneuraminic Acid	216-227	apolipoprotein E	Cricetulus griseus	0-4
2776735-5	1989	Treatments of factor B with neuraminidase and glycopeptidase F show that this microheterogeneity is mainly due to differences in its sialic acid content, varying from seven to eleven residues per molecule, and resulting in different oligosaccharide structures.	N-Acetylneuraminic Acid	133-144	neuraminidase 1	Homo sapiens	28-41
2506328-5	1989	The promoting effect of beta-galactosidase could be attributed to a decrease in repulsive forces due to a reduction in net negative charge density after removal of N-acetylneuraminic acid residues.	N-Acetylneuraminic Acid	164-187	galactosidase, beta 1	Rattus norvegicus	24-42
2477834-2	1989	The melanoma antigen is composed of a protein complex in association with GM3(NeuAc)-like sugar moiety.	N-Acetylneuraminic Acid	78-83	granulocyte macrophage antigen 3	Mus musculus	74-77
2470764-9	1989	The one unique feature of the carbohydrate groups of equine and guinea pig alpha 2-macroglobulins was the presence of 4-O-Ac-Neu5Ac as 30-50% of the total sialic acids, while human alpha 2-macroglobulin contained only Neu 5Ac.	N-Acetylneuraminic Acid	218-225	alpha-2-macroglobulin	Homo sapiens	75-96
2470765-10	1989	These and supporting results suggest that the key property of equine and guinea pig alpha 2-macroglobulin which make them high potency inhibitors is a spatial arrangement of sialic acid containing oligosaccharide groups which allows optimal interaction with multiple hemagglutinins.	N-Acetylneuraminic Acid	174-185	alpha-2-macroglobulin	Homo sapiens	84-105
2470823-0	1989	Expression of a binding structure for sialic acid-containing glycoconjugates on rat bone marrow-derived macrophages and its modulation by IFN, TNF-alpha, and dexamethasone.	N-Acetylneuraminic Acid	38-49	tumor necrosis factor	Rattus norvegicus	143-152
2470823-1	1989	Rat macrophages express a binding structure for sialic acid-containing glycoconjugates (sialic acid-binding receptor, SAR) which can be detected by a rosette assay utilizing SRBC coated with bovine brain gangliosides (E-G).	N-Acetylneuraminic Acid	48-59	sarcosinemia autosomal recessive	Mus musculus	118-121
2721445-3	1989	Enzymatic deglycosylation of hTeBG with neuraminidase to remove sialic acid led to the production of two subunits of 50,800 and 47,300 Mr when assessed by SDS-PAGE.	N-Acetylneuraminic Acid	64-75	neuraminidase 1	Homo sapiens	40-53
2505065-4	1989	Both the intact antibody and its Fab fragment bound to sialic acid poly- and oligomers to similar extents, the critical chain length being about 10 sialyl units for both molecules.	N-Acetylneuraminic Acid	55-66	FA complementation group B	Homo sapiens	33-36
2767779-3	1989	There was also a similar relationship between bound sialic acid and the enzyme sialyl-transferase.	N-Acetylneuraminic Acid	52-63	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	79-97
2542563-2	1989	The subunits gp120 and gp41 were then further modified by the addition of fucose, galactose, and sialic acid, resulting in glycoproteins containing a mixture of hybrid and complex oligosaccharide side chains.	N-Acetylneuraminic Acid	97-108	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	13-18
2507816-8	1989	These data suggest that N-acetylneuraminic acid (sialic acid) is the receptor for P. aeruginosa or a part of the receptor in acid injured rat trachea and in tracheobronchial mucin.	N-Acetylneuraminic Acid	24-47	solute carrier family 13 member 2	Rattus norvegicus	174-179
2507816-8	1989	These data suggest that N-acetylneuraminic acid (sialic acid) is the receptor for P. aeruginosa or a part of the receptor in acid injured rat trachea and in tracheobronchial mucin.	N-Acetylneuraminic Acid	49-60	solute carrier family 13 member 2	Rattus norvegicus	174-179
2719668-6	1989	Based on monosaccharide compositional analysis and glycosidase digestions, P2B was found to be 50-60% Asn-linked oligosaccharide containing polylactosamine sequences and sialic acid.	N-Acetylneuraminic Acid	170-181	lysosomal-associated membrane protein 1	Mus musculus	75-78
2722811-20	1989	Furthermore, the parallel shift of both the amount of apoE secreted associated with lipid as well as its isoform pattern to a more basic one by oleic acid suggests that the lipid availability plays a role in determining the lipid complement and sialic acid content of apoE secreted by the hepatocyte.	N-Acetylneuraminic Acid	245-256	apolipoprotein E	Rattus norvegicus	54-58
2540200-4	1989	Sialic acid was removed from surface-labeled K562 cultured human erythroleukemia cells by neuraminidase treatment.	N-Acetylneuraminic Acid	0-11	neuraminidase 1	Homo sapiens	90-103
2523818-5	1989	The results suggest that human monocyte IL-6 carries O-glycosidically bound carbohydrates with a Gal(beta 1-3)Gal-NAc core to which only sialic acid is bound.	N-Acetylneuraminic Acid	137-148	interleukin 6	Homo sapiens	40-44
2467938-7	1989	The results suggest that the recognition site which induces a reduction in the affinity of C3b for factor H is distinct from the thioester site of C3b and can recognize structural features of polysaccharides including size, sialic acid content, and possibly aspects of three-dimensional oligosaccharide structure.	N-Acetylneuraminic Acid	224-235	complement C3	Homo sapiens	91-94
2467938-7	1989	The results suggest that the recognition site which induces a reduction in the affinity of C3b for factor H is distinct from the thioester site of C3b and can recognize structural features of polysaccharides including size, sialic acid content, and possibly aspects of three-dimensional oligosaccharide structure.	N-Acetylneuraminic Acid	224-235	complement factor H	Homo sapiens	99-107
2705776-5	1989	Although high ionic strength or sialic acid liberation from the ovomucin gel by neuraminidase treatment provoked a decrease in viscosity, it was not followed by a change in non-Newtonian properties.	N-Acetylneuraminic Acid	32-43	neuraminidase 1	Homo sapiens	80-93
2705776-7	1989	Electrostatic interactions (partially destroyed by sialic acid removal or 2 M NaCl) and hydrophobic interactions might be responsible for protein-mucin and mucin-mucin interactions.	N-Acetylneuraminic Acid	51-62	LOC100508689	Homo sapiens	156-161
2705776-7	1989	Electrostatic interactions (partially destroyed by sialic acid removal or 2 M NaCl) and hydrophobic interactions might be responsible for protein-mucin and mucin-mucin interactions.	N-Acetylneuraminic Acid	51-62	LOC100508689	Homo sapiens	156-161
2755457-2	1989	The interaction with microsomal membranes was found to be abolished by pre-treatment of catalase with neuraminidase, indicating a functional significance for catalase-bound sialic acid.	N-Acetylneuraminic Acid	173-184	catalase	Mus musculus	88-96
2566398-4	1989	Increases in sialic acid content of GGT are associated with an increase in the activation energy of the catalyzed reaction.	N-Acetylneuraminic Acid	13-24	gamma-glutamyltransferase light chain family member 3	Homo sapiens	36-39
2765299-3	1989	After treatment with neuraminidase 2.92 nmol/mg dry weight and 3.73 nmol/mg dry weight of sialic acid were freed from U 251 cells and C6 cell, but only 8.11% (U 251 cell) and 11.24% (C 6 cell) of these sialic acids originated from glycolipid, and thus the major part of sialic acid might be released from glycoprotein of the cells.	N-Acetylneuraminic Acid	90-101	neuraminidase 2	Homo sapiens	21-36
2469454-5	1989	In addition, MSA contained N-acetyl neuraminic acid and N-acetyl glucosamine as indicated by its binding to wheat-germ agglutinin.	N-Acetylneuraminic Acid	27-51	thyroid peroxidase	Homo sapiens	13-16
2469454-6	1989	The epitope defined by antibody 3E1.2 is sensitive to treatment by sodium periodate and neuraminidase, implying that both carbohydrate and sialic acid are required for binding of antibody 3E1.2.	N-Acetylneuraminic Acid	139-150	neuraminidase 1	Homo sapiens	88-101
2503497-1	1989	Interferon-gamma produced by the human myelomonocyte cell line HBL-38 contained galactose, mannose, fucose, N-acetylglucosamine, and N-acetylneuraminic acid as sugar components.	N-Acetylneuraminic Acid	133-156	interferon gamma	Homo sapiens	0-16
2765299-3	1989	After treatment with neuraminidase 2.92 nmol/mg dry weight and 3.73 nmol/mg dry weight of sialic acid were freed from U 251 cells and C6 cell, but only 8.11% (U 251 cell) and 11.24% (C 6 cell) of these sialic acids originated from glycolipid, and thus the major part of sialic acid might be released from glycoprotein of the cells.	N-Acetylneuraminic Acid	202-213	neuraminidase 2	Homo sapiens	21-36
2755457-2	1989	The interaction with microsomal membranes was found to be abolished by pre-treatment of catalase with neuraminidase, indicating a functional significance for catalase-bound sialic acid.	N-Acetylneuraminic Acid	173-184	catalase	Mus musculus	158-166
2732208-1	1989	One of the characteristic features of the asparagine-linked sugar chains of human chorionic gonadotropin (hCG) is that their sialic acid residues occur exclusively as the Neu5Ac alpha 2----3Gal group.	N-Acetylneuraminic Acid	125-136	chorionic gonadotropin subunit beta 5	Homo sapiens	106-109
2917989-4	1989	The treatment of LTP with Clostridium perfringens neuraminidase shifted these multiple bands toward higher pH regions due to the release of sialic acid.	N-Acetylneuraminic Acid	140-151	neuraminidase 1	Homo sapiens	50-63
2663215-1	1989	The lipid-associated sialic acid (LASA) level in serum was increased in 663 out of 794 patients (83.5%) of which 55.1% were CEA negative.	N-Acetylneuraminic Acid	21-32	CEA cell adhesion molecule 3	Homo sapiens	124-127
2535260-1	1989	We have shown that a syngenic monoclonal antibody, M2590, established after immunization of C57BL/6 mice with B16 melanoma cells, recognized GM3 (NeuAc) ganglioside.	N-Acetylneuraminic Acid	146-151	granulocyte macrophage antigen 3	Mus musculus	141-144
2535260-7	1989	Liposomes containing GM3 (NeuAc) but not GM3 (NeuGc) can effectively induce the melanoma specific Ts as did the soluble antigen.	N-Acetylneuraminic Acid	26-31	granulocyte macrophage antigen 3	Mus musculus	21-24
2732208-1	1989	One of the characteristic features of the asparagine-linked sugar chains of human chorionic gonadotropin (hCG) is that their sialic acid residues occur exclusively as the Neu5Ac alpha 2----3Gal group.	N-Acetylneuraminic Acid	171-177	chorionic gonadotropin subunit beta 5	Homo sapiens	106-109
2910347-0	1989	The N-acetylneuraminic acid content of five forms of human transferrin.	N-Acetylneuraminic Acid	4-27	transferrin	Homo sapiens	59-70
2732208-2	1989	In order to determine whether this sialic acid linkage is important for the functional role played by the sugar moiety of hCG or not, isomeric hCG containing the Neu5Ac alpha 2----6Gal group was prepared and its hormonal activity in vitro was investigated.	N-Acetylneuraminic Acid	162-168	chorionic gonadotropin subunit beta 5	Homo sapiens	143-146
2537104-7	1989	Since glycophorin A is reportedly linked to the erythrocyte membrane skeletal protein network by band 4.1, it is conceivable that hemin-induced disruption of skeletal protein interactions, particularly those of band 4.1, could subsequently lead to the alterations in the motion of cell-surface sialic acid presented in this report.	N-Acetylneuraminic Acid	294-305	glycophorin A (MNS blood group)	Homo sapiens	6-19
2910347-1	1989	Five isoforms of human serum transferrin were separated by isoelectric focusing and their N-acetylneuraminic acid content was determined.	N-Acetylneuraminic Acid	90-113	transferrin	Homo sapiens	29-40
2910347-7	1989	Comparison of the sialic acid content of the five transferrin forms and their carbohydrate structures showed that some of the forms expose terminal galactose without attracting the asialoglycoprotein receptors on hepatocytes.	N-Acetylneuraminic Acid	18-29	transferrin	Homo sapiens	50-61
2463989-5	1989	GMP-140 contained 28.8% carbohydrate by weight, distributed among N-acetylneuraminic acid, neutral sugar, and N-acetylglucosamine residues.	N-Acetylneuraminic Acid	66-89	selectin P	Homo sapiens	0-7
2706085-9	1989	The amount of sialic acid was 15 mol/mol THP.	N-Acetylneuraminic Acid	14-25	uromodulin	Homo sapiens	41-44
2706085-10	1989	Using lectins to identify the structure of the carbohydrate chains it was shown that rabbit Tamm-Horsfall protein possesses complex-type oligosaccharide chains with terminal sialic acid, beta-galactose, and probably alpha-fucose and chains of the mucin type.	N-Acetylneuraminic Acid	174-185	uromodulin	Homo sapiens	92-113
2492258-4	1989	A third, sialic acid-specific adhesion activity was suggested for two additional strains on the basis of their agglutination of native and endo-beta-galactosidase-treated but not sialidase-treated erythrocytes.	N-Acetylneuraminic Acid	9-20	galactosidase beta 1	Homo sapiens	144-162
2915974-8	1989	Antibodies that bind to the sialic acid-rich region of N-CAM bound near the hinge.	N-Acetylneuraminic Acid	28-39	neural cell adhesion molecule 1	Homo sapiens	55-60
2720797-5	1989	Treatment with theophylline, in contrast, markedly elevated the sialic acid content, which was accompanied by dramatic increments in tyrosinase activity and pigmentation as well as a slight increase in adhesiveness.	N-Acetylneuraminic Acid	64-75	tyrosinase	Mus musculus	133-143
2720797-6	1989	The results show a correlation of sialic acid level with tyrosinase expression but not with cell adhesion.	N-Acetylneuraminic Acid	34-45	tyrosinase	Mus musculus	57-67
2720797-7	1989	From comparison of spontaneous phenotypic variations, the correlation of sialic acid level with tyrosinase activity was confirmed, while there was only a slight correlation with adhesiveness.	N-Acetylneuraminic Acid	73-84	tyrosinase	Mus musculus	96-106
2720797-8	1989	It is thus suggested that sialylation/desialylation, being reflected as variations in cellular sialic acid content, is implicated in melanoma cell differentiation in terms of tyrosinase expression.	N-Acetylneuraminic Acid	95-106	tyrosinase	Mus musculus	175-185
2720800-3	1989	Treatment of the cells with WGA, which binds to N-acetylglucosamine and sialic acid residues on glycoproteins, strongly blocked the inhibitory action of NGF on the protein phosphorylation.	N-Acetylneuraminic Acid	72-83	nerve growth factor	Rattus norvegicus	153-156
2720800-7	1989	Since the binding of succinylated WGA to N-acetylglucosamine residues of cell-surface glycoconjugates is not sufficient to prevent the action of NGF, WGA might act on sialic acid residues of the NGF receptor molecule to effect the inhibition of biological actions of NGF.	N-Acetylneuraminic Acid	167-178	nerve growth factor receptor	Rattus norvegicus	195-207
2720800-7	1989	Since the binding of succinylated WGA to N-acetylglucosamine residues of cell-surface glycoconjugates is not sufficient to prevent the action of NGF, WGA might act on sialic acid residues of the NGF receptor molecule to effect the inhibition of biological actions of NGF.	N-Acetylneuraminic Acid	167-178	nerve growth factor	Rattus norvegicus	195-198
2710786-0	1989	Striking sequence similarity among sialic acid-binding lectin, pancreatic ribonucleases, and angiogenin: possible structural and functional relationships.	N-Acetylneuraminic Acid	35-46	angiogenin	Homo sapiens	93-103
2710786-1	1989	We found that a sialic acid-binding lectin (SABL) from bullfrog egg bears a remarkable degree of similarity with human angiogenin and the pancreatic ribonucleases (EC 3.1.27.5).	N-Acetylneuraminic Acid	16-27	angiogenin	Homo sapiens	119-129
2916442-2	1989	The distribution of binding sites for a lectin from the peanut Arachis hypogaea (PNA) conjugated to horseradish peroxidase (HRP) was determined on tissue sections both before and after enzymatic cleavage of sialic acid with neuraminidase (sialidase).	N-Acetylneuraminic Acid	207-218	galectin 3	Gallus gallus	40-46
2535773-4	1989	The nature of the intraindividual biochemical variation can be explained by differences in sialic acid content because after digestion with neuraminidase the terminal sialic acids are removed to yield a single major band corresponding to the C1R polypeptide.	N-Acetylneuraminic Acid	91-102	complement C1r	Homo sapiens	242-245
2529107-6	1989	In particular, we have shown that O-glycans of leukosialin are converted from NeuAc(alpha 2-3)Gal(beta 1-3) [NeuAc(alpha 2-6)]-GalNAc to NeuAc(alpha 2-3)Gal(beta 1-3) [NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-6)] GalNAc during T cell activation.	N-Acetylneuraminic Acid	78-83	LOC105369247	Homo sapiens	47-58
2910371-9	1989	These results suggest that (a) the sialic acid of the recombinant erythropoietin is necessary for this glycoprotein hormone to circulate stably and (b) glycoproteins with more than three lactosaminyl repeat units may be cleared by the galactose binding protein of hepatocytes.	N-Acetylneuraminic Acid	35-46	erythropoietin	Homo sapiens	66-80
2908845-11	1989	Mouse anti-GD3 mAbR24, in contrast, showed strong reactivity only with GD3 and -disialylparagloboside among NeuAc-type gangliosides, but showed a similar pattern to AbHJM1 in its reactivity with NeuGc-containing gangliosides.	N-Acetylneuraminic Acid	108-113	GRDX	Homo sapiens	11-14
2529107-6	1989	In particular, we have shown that O-glycans of leukosialin are converted from NeuAc(alpha 2-3)Gal(beta 1-3) [NeuAc(alpha 2-6)]-GalNAc to NeuAc(alpha 2-3)Gal(beta 1-3) [NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-6)] GalNAc during T cell activation.	N-Acetylneuraminic Acid	109-114	LOC105369247	Homo sapiens	47-58
2529107-6	1989	In particular, we have shown that O-glycans of leukosialin are converted from NeuAc(alpha 2-3)Gal(beta 1-3) [NeuAc(alpha 2-6)]-GalNAc to NeuAc(alpha 2-3)Gal(beta 1-3) [NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-6)] GalNAc during T cell activation.	N-Acetylneuraminic Acid	109-114	LOC105369247	Homo sapiens	47-58
2529107-6	1989	In particular, we have shown that O-glycans of leukosialin are converted from NeuAc(alpha 2-3)Gal(beta 1-3) [NeuAc(alpha 2-6)]-GalNAc to NeuAc(alpha 2-3)Gal(beta 1-3) [NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-6)] GalNAc during T cell activation.	N-Acetylneuraminic Acid	109-114	LOC105369247	Homo sapiens	47-58
3189316-9	1988	This study 1) confirmed that asialotransferrin-iron uptake by the hepatocyte is mediated by both transferrin and asialoglycoprotein receptors; 2) demonstrated that not only asialotransferrin but also transferrin of low sialic acid content will increase iron turnover and lead to excessive iron loading of the hepatocyte; 3) and showed that the intrahepatocyte metabolism of asialotransferrin-iron did not differ from that of iron delivered by normal transferrin.	N-Acetylneuraminic Acid	219-230	transferrin	Homo sapiens	35-46
2542012-8	1989	In terms of specificity, the enzyme catalyzed the hydrolysis of sialic acid linkages in mucin, glycoproteins, and gangliosides: bovine submaxillary mucin supported the highest catalytic efficiency, and alpha-1-antitrypsin the lowest.	N-Acetylneuraminic Acid	64-75	serpin family A member 1	Bos taurus	202-221
2542012-9	1989	Neuraminidase acted on at least three linkage classes of substrates, alpha-2,6 and alpha-2,3 linkages of N-acetylneuraminic acid to galactose, and alpha-2,6 linkages to N-acetyl-galactosamine.	N-Acetylneuraminic Acid	105-128	neuraminidase 1	Homo sapiens	0-13
2535479-7	1989	NeuAc alpha 2-3Gal beta 1-3[Fuc alpha 1-4]GlcNAc beta 1-3Gal beta 1-4Glc; 6.	N-Acetylneuraminic Acid	0-5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	19-25
2535479-7	1989	NeuAc alpha 2-3Gal beta 1-3[Fuc alpha 1-4]GlcNAc beta 1-3Gal beta 1-4Glc; 6.	N-Acetylneuraminic Acid	0-5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	49-55
2535479-10	1989	NeuAc alpha 2-6Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc.	N-Acetylneuraminic Acid	0-5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	19-25
2535479-10	1989	NeuAc alpha 2-6Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc.	N-Acetylneuraminic Acid	0-5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	34-40
2466778-0	1989	Sialic acid-dependent epitopes of CD45 molecules of restricted cellular expression.	N-Acetylneuraminic Acid	0-11	protein tyrosine phosphatase receptor type C	Homo sapiens	34-38
2523355-3	1989	Fc epsilon R II is a 45-KD glycoprotein containing one N-linked carbohydrate of complex type, O-linked carbohydrates, and sialic acid residues.	N-Acetylneuraminic Acid	122-133	Fc epsilon receptor II	Homo sapiens	0-15
2569734-4	1989	The chemical characteristics of the GGTPs in the spent media from these cell lines resembled one of the GGTPs, sialic acid-rich GGTP, extracted from normal human pancreas with bromelain treatment as follows: the GGTPs secreted from the cancer cell lines bound to an anion exchange column moved fast on electrophoresis and then showed decreased electrophoretic mobility with neuraminidase treatment, showed a high affinity for concanavalin A and lentil lectin columns, and had an acidic isoelectric point.	N-Acetylneuraminic Acid	111-122	inactive glutathione hydrolase 2	Homo sapiens	36-40
2569734-4	1989	The chemical characteristics of the GGTPs in the spent media from these cell lines resembled one of the GGTPs, sialic acid-rich GGTP, extracted from normal human pancreas with bromelain treatment as follows: the GGTPs secreted from the cancer cell lines bound to an anion exchange column moved fast on electrophoresis and then showed decreased electrophoretic mobility with neuraminidase treatment, showed a high affinity for concanavalin A and lentil lectin columns, and had an acidic isoelectric point.	N-Acetylneuraminic Acid	111-122	neuraminidase 1	Homo sapiens	374-387
2587787-6	1989	Moreover, the extent of the apo E sialylation seems to be important because the modification of apo E by sialic acid alters its metabolism.	N-Acetylneuraminic Acid	105-116	apolipoprotein E	Homo sapiens	28-33
2587787-6	1989	Moreover, the extent of the apo E sialylation seems to be important because the modification of apo E by sialic acid alters its metabolism.	N-Acetylneuraminic Acid	105-116	apolipoprotein E	Homo sapiens	96-101
3142874-4	1988	Fragmentation analysis of oligo(poly)sialyl chains in lake trout PSGP(Sn) has established that there are two distinct types of oligo(poly)sialyl structures in this PSGP molecule, namely alpha-2,8-linked oligo/poly(Neu5Ac) and alpha-2,8-linked oligo/poly(Neu5Gc).	N-Acetylneuraminic Acid	214-220	polysialoglycoprotein	Oncorhynchus mykiss	65-69
2460229-13	1988	Two of these epitopes (MCA-b-8 and MCA-b-15) are O-linked carbohydrates, and one (MCA-b-15) contains sialic acid.	N-Acetylneuraminic Acid	101-112	NADH:ubiquinone oxidoreductase subunit B4	Homo sapiens	86-90
2535479-4	1989	NeuAc alpha 2-3Gal beta 1-3GlcNAc beta 1-3Gal beta 1-4Glc; 3.	N-Acetylneuraminic Acid	0-5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	19-25
2535479-4	1989	NeuAc alpha 2-3Gal beta 1-3GlcNAc beta 1-3Gal beta 1-4Glc; 3.	N-Acetylneuraminic Acid	0-5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	34-40
2535479-6	1989	NeuAc alpha 2-3Gal beta 1-3[NeuAc alpha 2-6]GlcNAc beta 1-3Gal beta 1-4Glc; 5.	N-Acetylneuraminic Acid	0-5	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	19-27
2535479-6	1989	NeuAc alpha 2-3Gal beta 1-3[NeuAc alpha 2-6]GlcNAc beta 1-3Gal beta 1-4Glc; 5.	N-Acetylneuraminic Acid	0-5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	19-25
2535479-6	1989	NeuAc alpha 2-3Gal beta 1-3[NeuAc alpha 2-6]GlcNAc beta 1-3Gal beta 1-4Glc; 5.	N-Acetylneuraminic Acid	0-5	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	51-57
2591981-6	1989	Reduction of this pattern to a single primary band following neuraminidase treatment indicates that the observed intraindividual variation is due to variation in the number of sialic acid residues associated with CBG.	N-Acetylneuraminic Acid	176-187	neuraminidase 1	Homo sapiens	61-74
2591981-6	1989	Reduction of this pattern to a single primary band following neuraminidase treatment indicates that the observed intraindividual variation is due to variation in the number of sialic acid residues associated with CBG.	N-Acetylneuraminic Acid	176-187	serpin family A member 6	Homo sapiens	213-216
2535725-7	1989	The presence of a higher content of sialic acid on the apathogenic 61E gp70 indicated that oligosaccharides of 61E and EECC gp70 were processed differently.	N-Acetylneuraminic Acid	36-47	embigin	Homo sapiens	71-75
2535725-7	1989	The presence of a higher content of sialic acid on the apathogenic 61E gp70 indicated that oligosaccharides of 61E and EECC gp70 were processed differently.	N-Acetylneuraminic Acid	36-47	embigin	Homo sapiens	124-128
2779380-3	1989	Neuraminidase treatment of whole blood to decrease sialic acid content significantly increased the ESR.	N-Acetylneuraminic Acid	51-62	neuraminidase 1	Homo sapiens	0-13
2781221-10	1989	The findings imply that electrophoretic heterogeneity demonstrated in LAP in seminoma and in normal testis is caused by a difference in sialic acid content in the molecule, and the heterogeneity of the PLAP-like enzyme in seminoma is considerable.	N-Acetylneuraminic Acid	136-147	LAP	Homo sapiens	70-73
2482622-3	1989	A common structural feature of NCAM is the presence of homopolymers of alpha 2,8-linked sialic acid residues, the so-called polysialic acid, which is developmentally regulated.	N-Acetylneuraminic Acid	88-99	neural cell adhesion molecule 1	Homo sapiens	31-35
3182859-9	1988	In contrast, the sialic acid residues of other interferon-beta 1 occur as the Sia alpha 2----3Gal group only.	N-Acetylneuraminic Acid	17-28	interferon beta 1	Homo sapiens	47-64
3058545-6	1988	A similar reduction of nerve branching was obtained following injection of an endosialidase, which removes sialic acid from NCAM, and which was observed to enhance fiber-fiber apposition, presumably by increasing cell adhesion.	N-Acetylneuraminic Acid	107-118	neural cell adhesion molecule 1	Gallus gallus	124-128
3142912-9	1988	In seven of the nine subjects with TBG excess, the abnormality was associated with conditions known to increase its sialic acid content: hepatitis (one subject), pregnancy (four subjects), and estrogen therapy (two subjects).	N-Acetylneuraminic Acid	116-127	serpin family A member 7	Homo sapiens	35-38
3264007-7	1988	Consistent with previous observations on macrophage gangliosides, the ratio of N-acetylneuraminic acid-containing ganglioside to N-glycolylneuraminic acid-containing ganglioside was higher in both thymocytes and T-cells from the LPS-responder strain.	N-Acetylneuraminic Acid	79-102	toll-like receptor 4	Mus musculus	229-232
3060828-1	1988	Comparison of the adult brain insulin receptor (IR) to other tissue IR demonstrates that the former migrates approximately 10 kD faster on sodium dodecyl sulfate-polyacrylamide gel electrophoresis due to deficient sialic acid content of the asparagine N-linked carbohydrate moieties.	N-Acetylneuraminic Acid	214-225	insulin receptor	Rattus norvegicus	30-46
3060828-1	1988	Comparison of the adult brain insulin receptor (IR) to other tissue IR demonstrates that the former migrates approximately 10 kD faster on sodium dodecyl sulfate-polyacrylamide gel electrophoresis due to deficient sialic acid content of the asparagine N-linked carbohydrate moieties.	N-Acetylneuraminic Acid	214-225	insulin receptor	Rattus norvegicus	48-50
3060828-5	1988	The neuronal (approximately 125 kD) and microvascular (approximately 125 kD, approximately 135 kD) IR are deficient in sialic acid, thus conferring neuraminidase-insensitivity to the whole brain, whereas the glial cell IR, similar to the liver IR, exhibits neuraminidase sensitivity and migrates intermediate (approximately 128 kD) to the liver and brain IR.	N-Acetylneuraminic Acid	119-130	insulin receptor	Rattus norvegicus	99-101
2460142-6	1988	PRP contained fucose, mannose, galactose, glucosamine and sialic acid accounting for 8.0% of the dry weight.	N-Acetylneuraminic Acid	58-69	complement component 4 binding protein alpha	Homo sapiens	0-3
2848703-2	1988	a) Despite the space-filling substituent at C-9, the fluorescent NeuAc analogue was activated to the corresponding CMP-glycoside by CMP sialic acid synthase from bovine brain.	N-Acetylneuraminic Acid	65-70	complement C9	Bos taurus	44-47
2846530-3	1988	Bone acidic glycoprotein-75 is 75,000 in molecular weight with a 29.3% molar content of acidic amino acid residues, a 7.0% (w/w) content of sialic acid, and a 7.9% molar content of organic phosphate.	N-Acetylneuraminic Acid	140-151	tyrosinase related protein 1	Homo sapiens	12-27
3239749-14	1988	Using this approach, complete separation of the parent neutral structures was obtained, the relative proportions of the neutral species were quantified, and the amount of sialic acid released was easily determined in a neuraminidase digest.	N-Acetylneuraminic Acid	171-182	neuraminidase 1	Homo sapiens	219-232
2853718-5	1988	Enzymatic deglycosylation studies suggested that the 120,000 and 100,000 proteins were LDL receptor precursors lacking sialic acid.	N-Acetylneuraminic Acid	119-130	low density lipoprotein receptor	Rattus norvegicus	87-99
2975169-7	1988	Neuraminidase treatment reduced the low-affinity population suggesting that the interaction of oligosaccharides bearing sialic acid with WGA-agarose is of lower affinity and that higher-affinity binding is via N-acetylglucosamine.	N-Acetylneuraminic Acid	120-131	neuraminidase 1	Bos taurus	0-13
2460162-0	1988	Sialic acid prevents loss of large von Willebrand factor multimers by protecting against amino-terminal proteolytic cleavage.	N-Acetylneuraminic Acid	0-11	von Willebrand factor	Homo sapiens	35-56
2460162-1	1988	Removal of sialic acid from the von Willebrand factor (vWF) subunit exposes additional cleavage sites in the amino-terminal region that are associated with loss of large multimers.	N-Acetylneuraminic Acid	11-22	von Willebrand factor	Homo sapiens	32-53
2460162-1	1988	Removal of sialic acid from the von Willebrand factor (vWF) subunit exposes additional cleavage sites in the amino-terminal region that are associated with loss of large multimers.	N-Acetylneuraminic Acid	11-22	von Willebrand factor	Homo sapiens	55-58
2460162-3	1988	In the presence of proteinase inhibitors, purified vWF was treated with neuraminidase alone to remove 90% to 95% of the sialic acid or with neuraminidase and beta-galactosidase to remove the sialic acid and 45% to 50% of the D-galactose, with little or no loss of large multimers observed.	N-Acetylneuraminic Acid	120-131	von Willebrand factor	Homo sapiens	51-54
2460162-3	1988	In the presence of proteinase inhibitors, purified vWF was treated with neuraminidase alone to remove 90% to 95% of the sialic acid or with neuraminidase and beta-galactosidase to remove the sialic acid and 45% to 50% of the D-galactose, with little or no loss of large multimers observed.	N-Acetylneuraminic Acid	191-202	von Willebrand factor	Homo sapiens	51-54
2460162-11	1988	By protecting the vWF subunit against amino-terminal cleavage, sialic acid inhibits the loss of large multimers.	N-Acetylneuraminic Acid	63-74	von Willebrand factor	Homo sapiens	18-21
3192617-5	1988	This enhanced LDL endocytosis in neuraminidase-treated cells was dependent upon the enzymatic activity of the neuraminidase and the removal of sialic acid from the cell surface.	N-Acetylneuraminic Acid	143-154	neuraminidase 1	Bos taurus	33-46
3192617-10	1988	These results indicate that sialic acid associated with either adjacent endothelial cell surface molecules or the endothelial LDL receptor itself may modulate LDL receptor-mediated endocytosis and suggest that this regulatory mechanism may be of particular importance to endothelial cells.	N-Acetylneuraminic Acid	28-39	low density lipoprotein receptor	Bos taurus	126-138
3192617-10	1988	These results indicate that sialic acid associated with either adjacent endothelial cell surface molecules or the endothelial LDL receptor itself may modulate LDL receptor-mediated endocytosis and suggest that this regulatory mechanism may be of particular importance to endothelial cells.	N-Acetylneuraminic Acid	28-39	low density lipoprotein receptor	Bos taurus	159-171
3049818-4	1988	In order to further elucidate the role of CD43 in various T cell functions we have studied the biologic properties of two other mAb (B1B6 and E11B, IgG1) directed against sialic acid-dependent epitopes on CD43.	N-Acetylneuraminic Acid	171-182	sialophorin	Homo sapiens	42-46
3217921-1	1988	The effect of enzymatic removal of sialic acid residues on the functional properties of human protein C was examined.	N-Acetylneuraminic Acid	35-46	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	94-103
3217921-7	1988	Our studies suggest that the sialic acid component of protein C is not essential for the expression of APC activity but may act to modulate the function of the protein.	N-Acetylneuraminic Acid	29-40	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	54-63
3170547-4	1988	Studies on glycopeptides modified by desialylation, desulfation, and beta-galactosidase treatment indicated that the majority (approximately 70%) of the complex carbohydrate units contain sulfate groups and that Gal-3-SO4 and sialic acid residues can coexist in terminal positions on the same N-linked oligosaccharide.	N-Acetylneuraminic Acid	226-237	galectin 3	Homo sapiens	212-217
2972556-4	1988	Data from crosslinking experiments with and without neuraminidase treatment indicate that the binding subunits of the retinal IGF-I receptor exist in two subpopulations (Mr = 121- and 131 kDa), and that the larger of the two subunits has either a greater number or more exposed sialic acid residues.	N-Acetylneuraminic Acid	278-289	insulin like growth factor 1 receptor	Bos taurus	126-140
3242652-8	1988	Removal of sialic acid from GCDFP-15 resulted in a more rapid clearance (t1/2 = 2.2 min) by the liver (85%).	N-Acetylneuraminic Acid	11-22	prolactin induced protein	Homo sapiens	28-36
2852963-7	1988	The VIP binding site of intact human adenocarcinoma cells (HT29 cells) is an Mr 64,000 glycoprotein with 20kDa of N-linked oligosaccharide side chains containing sialic acid.	N-Acetylneuraminic Acid	162-173	vasoactive intestinal peptide	Homo sapiens	4-7
2845024-3	1988	Red cell surface charge was reduced by using the enzyme neuraminidase to remove the terminal charge-bearing sialic acid moiety of the membrane glycoprotein.	N-Acetylneuraminic Acid	108-119	neuraminidase 1	Homo sapiens	56-69
2466854-6	1988	There was a significant correlation between the levels of sialic acid and those of alpha 1-AT in sera of patients with NIDDM.	N-Acetylneuraminic Acid	58-69	serpin family A member 1	Homo sapiens	83-93
3409215-6	1988	In contrast, P2A bound specifically to collagen type I and the interaction required the presence of sialic acid residues which were sensitive to neuraminidase digestion but not to endoglycosidase F. The results suggest that oncodevelopmental regulation of oligosaccharide expression on P2A and P2B glycoproteins may modulate their binding to extracellular matrix glycoproteins.	N-Acetylneuraminic Acid	100-111	lysosomal-associated membrane protein 1	Mus musculus	294-297
3169252-1	1988	The sequential removal of N-acetylneuraminic acid from rabbit serum transferrin has been followed by urea-polyacrylamide gel electrophoresis.	N-Acetylneuraminic Acid	26-49	transferrin	Homo sapiens	68-79
3137974-10	1988	On the other hand, a lower colipase affinity for isolipases A or C than for isolipase B or the C-terminal peptide could tentatively be attributed to a non-local (distant) disturbing effect of the negatively charged glycan chain, as sialic acid is present in both isoforms A and C. Finally, the present paper confirms and extends earlier studies on lipase-colipase interactions.	N-Acetylneuraminic Acid	232-243	colipase	Sus scrofa	27-35
3409215-5	1988	Enzymatic removal of sialic acid, polylactosamine, or complete asparagine-linked chains from purified P2B enhanced its binding to collagen, laminin, and fibronectin.	N-Acetylneuraminic Acid	21-32	lysosomal-associated membrane protein 1	Mus musculus	102-105
3253055-8	1988	The kinetics of [14C]sialic acid incorporation into immuno-precipitated N-CAM demonstrated the individual polypeptides to be sialylated, possibly by addition of polysialosyl units, in a developmental sequence.	N-Acetylneuraminic Acid	21-32	neural cell adhesion molecule 1	Rattus norvegicus	72-77
3409215-5	1988	Enzymatic removal of sialic acid, polylactosamine, or complete asparagine-linked chains from purified P2B enhanced its binding to collagen, laminin, and fibronectin.	N-Acetylneuraminic Acid	21-32	fibronectin 1	Mus musculus	153-164
2457654-7	1988	The data suggest that the epitope for both of these IgMs is in the GalNAc(beta 1-4)(NeuAc alpha 2-3)Gal(beta 1-4)Glc region of the gangliosides that is common to both GM2 and GM1.	N-Acetylneuraminic Acid	84-89	tubulin beta 3 class III	Homo sapiens	74-82
3402396-12	1988	Among the three batches of hCGv, their inhibitory effects on bTSH binding and adenylate cyclase activation appeared to vary inversely with with their sialic acid content.	N-Acetylneuraminic Acid	150-161	protein phosphatase 1 regulatory inhibitor subunit 11	Homo sapiens	27-31
2457654-7	1988	The data suggest that the epitope for both of these IgMs is in the GalNAc(beta 1-4)(NeuAc alpha 2-3)Gal(beta 1-4)Glc region of the gangliosides that is common to both GM2 and GM1.	N-Acetylneuraminic Acid	84-89	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	104-112
2466087-0	1988	Glucosamine and sialic acid content of gastric mucin in subjects with hepatic cirrhosis.	N-Acetylneuraminic Acid	16-27	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	39-52
2464369-9	1988	Isoelectric focusing of the HeLa and hCG subunits demonstrated that the tumor protein had a lower pI (4.7-5.5 compared to 6.5-7.8), and removal of sialic acid by mild acid hydrolysis did not entirely eliminate this difference.	N-Acetylneuraminic Acid	147-158	chorionic gonadotropin subunit beta 5	Homo sapiens	37-40
3409533-2	1988	These transferrin forms differ in the carbohydrate parts, especially the amount of sialic acid.	N-Acetylneuraminic Acid	83-94	transferrin	Homo sapiens	6-17
3409533-4	1988	However, in alcoholics during abstinence the newly formed transferrin has a higher sialic acid content than most of the transferrin already present in the blood.	N-Acetylneuraminic Acid	83-94	transferrin	Homo sapiens	58-69
3409533-5	1988	This indicates that the elevated concentration of Tf5.7 with a low sialic acid content, found in alcoholics is not due to a defect at sialylation, but most probably caused by an impaired uptake of sialic acid-deficient transferrin by the hepatocytes due to membrane dysfunction.	N-Acetylneuraminic Acid	197-208	transferrin	Homo sapiens	219-230
3365702-5	1988	These bands disappear, or their molecular weight is affected, after treatment of the cells with cycloheximide or of cell lysates with trypsin, Pronase, or neuraminidase but not treatment of the immunoprecipitate with endoglycosidase F. This suggests that these antigens are glycoproteins with O-linked oligosaccharides containing sialic acid in the epitope.	N-Acetylneuraminic Acid	330-341	neuraminidase 1	Homo sapiens	155-168
3392212-3	1988	The cochemotaxin attaches to sialic acid residues within the oligosaccharide chain of native C5a des Arg to form a complex with potent chemotactic activity for human PMN.	N-Acetylneuraminic Acid	29-40	complement C5a receptor 1	Homo sapiens	93-96
3392212-6	1988	Sialic acid prevented both enhancement by vitamin D-binding protein of the chemotactic activity of native C5a des Arg and formation of C5a des Arg-vitamin D-binding protein complexes, detected by molecular sieve chromatography.	N-Acetylneuraminic Acid	0-11	GC vitamin D binding protein	Homo sapiens	42-67
3392212-6	1988	Sialic acid prevented both enhancement by vitamin D-binding protein of the chemotactic activity of native C5a des Arg and formation of C5a des Arg-vitamin D-binding protein complexes, detected by molecular sieve chromatography.	N-Acetylneuraminic Acid	0-11	complement C5a receptor 1	Homo sapiens	106-109
3392212-6	1988	Sialic acid prevented both enhancement by vitamin D-binding protein of the chemotactic activity of native C5a des Arg and formation of C5a des Arg-vitamin D-binding protein complexes, detected by molecular sieve chromatography.	N-Acetylneuraminic Acid	0-11	complement C5a receptor 1	Homo sapiens	135-138
3392212-6	1988	Sialic acid prevented both enhancement by vitamin D-binding protein of the chemotactic activity of native C5a des Arg and formation of C5a des Arg-vitamin D-binding protein complexes, detected by molecular sieve chromatography.	N-Acetylneuraminic Acid	0-11	GC vitamin D binding protein	Homo sapiens	147-172
3178866-5	1988	Pre-treatment of cells with neuraminidase or proteinase K suggests that: a) sialic acid seems to be essential for the cell-liposome fusion process, no enrichment being found with the neuraminidase-treated cells; b) hydrolysis of the outer membrane proteins leads to an increased fragility with respect to controls even in GPX-enriched cells.	N-Acetylneuraminic Acid	76-87	neuraminidase 1	Homo sapiens	28-41
3390395-5	1988	Analysis of surface neuraminidase-labile sialic acid of the platelets in pools A and C correlated well with differences in electrophoretic mobility, whereas a similar relationship for the alkaline phosphatase-labile phosphate moieties (also believed to be contributory to cell surface electrokinetic properties) could not be established even though in both cases the profiles of the enzyme-treated platelets showed significant shifts towards the cathode when compared with untreated cells.	N-Acetylneuraminic Acid	41-52	neuraminidase 1	Homo sapiens	20-33
3138980-2	1988	Pig kidney diamine oxidase (DAO) was found to contain 5% (w/w) natural hexose, 3.25% glucosamine, 2.61% N-acetylglucosamine and 0.25% N-acetylneuraminic acid.	N-Acetylneuraminic Acid	134-157	amine oxidase copper containing 1	Sus scrofa	11-26
3138980-2	1988	Pig kidney diamine oxidase (DAO) was found to contain 5% (w/w) natural hexose, 3.25% glucosamine, 2.61% N-acetylglucosamine and 0.25% N-acetylneuraminic acid.	N-Acetylneuraminic Acid	134-157	amine oxidase copper containing 1	Sus scrofa	28-31
3220834-9	1988	Most of the administered [3H]GM1(NeuAc)-NMe was incorporated in the liver, and was metabolized to GM3(NeuAc)-NMe, via GM2(NeuAc)-NMe, within 24 h. GM3(NeuAc)-NMe was the only radioactive compound in the subsequent 10 weeks, but disappeared from the liver gradually.	N-Acetylneuraminic Acid	33-38	granulocyte macrophage antigen 3	Mus musculus	98-101
3220834-9	1988	Most of the administered [3H]GM1(NeuAc)-NMe was incorporated in the liver, and was metabolized to GM3(NeuAc)-NMe, via GM2(NeuAc)-NMe, within 24 h. GM3(NeuAc)-NMe was the only radioactive compound in the subsequent 10 weeks, but disappeared from the liver gradually.	N-Acetylneuraminic Acid	33-38	cytochrome b5 domain containing 2	Mus musculus	118-121
3220834-9	1988	Most of the administered [3H]GM1(NeuAc)-NMe was incorporated in the liver, and was metabolized to GM3(NeuAc)-NMe, via GM2(NeuAc)-NMe, within 24 h. GM3(NeuAc)-NMe was the only radioactive compound in the subsequent 10 weeks, but disappeared from the liver gradually.	N-Acetylneuraminic Acid	33-38	granulocyte macrophage antigen 3	Mus musculus	147-150
3220834-9	1988	Most of the administered [3H]GM1(NeuAc)-NMe was incorporated in the liver, and was metabolized to GM3(NeuAc)-NMe, via GM2(NeuAc)-NMe, within 24 h. GM3(NeuAc)-NMe was the only radioactive compound in the subsequent 10 weeks, but disappeared from the liver gradually.	N-Acetylneuraminic Acid	102-107	granulocyte macrophage antigen 3	Mus musculus	98-101
3220834-9	1988	Most of the administered [3H]GM1(NeuAc)-NMe was incorporated in the liver, and was metabolized to GM3(NeuAc)-NMe, via GM2(NeuAc)-NMe, within 24 h. GM3(NeuAc)-NMe was the only radioactive compound in the subsequent 10 weeks, but disappeared from the liver gradually.	N-Acetylneuraminic Acid	102-107	cytochrome b5 domain containing 2	Mus musculus	118-121
3220834-9	1988	Most of the administered [3H]GM1(NeuAc)-NMe was incorporated in the liver, and was metabolized to GM3(NeuAc)-NMe, via GM2(NeuAc)-NMe, within 24 h. GM3(NeuAc)-NMe was the only radioactive compound in the subsequent 10 weeks, but disappeared from the liver gradually.	N-Acetylneuraminic Acid	102-107	granulocyte macrophage antigen 3	Mus musculus	98-101
3220834-9	1988	Most of the administered [3H]GM1(NeuAc)-NMe was incorporated in the liver, and was metabolized to GM3(NeuAc)-NMe, via GM2(NeuAc)-NMe, within 24 h. GM3(NeuAc)-NMe was the only radioactive compound in the subsequent 10 weeks, but disappeared from the liver gradually.	N-Acetylneuraminic Acid	102-107	cytochrome b5 domain containing 2	Mus musculus	118-121
3220834-9	1988	Most of the administered [3H]GM1(NeuAc)-NMe was incorporated in the liver, and was metabolized to GM3(NeuAc)-NMe, via GM2(NeuAc)-NMe, within 24 h. GM3(NeuAc)-NMe was the only radioactive compound in the subsequent 10 weeks, but disappeared from the liver gradually.	N-Acetylneuraminic Acid	102-107	granulocyte macrophage antigen 3	Mus musculus	98-101
3220834-9	1988	Most of the administered [3H]GM1(NeuAc)-NMe was incorporated in the liver, and was metabolized to GM3(NeuAc)-NMe, via GM2(NeuAc)-NMe, within 24 h. GM3(NeuAc)-NMe was the only radioactive compound in the subsequent 10 weeks, but disappeared from the liver gradually.	N-Acetylneuraminic Acid	102-107	cytochrome b5 domain containing 2	Mus musculus	118-121
2462932-3	1988	Using hCG, asialo-hCG (A-hCG) and DG-hCG, we have shown that removal of sugars internal to sialic acid is required to produce these specific antibodies.	N-Acetylneuraminic Acid	91-102	chorionic gonadotropin subunit beta 5	Homo sapiens	6-9
2462932-3	1988	Using hCG, asialo-hCG (A-hCG) and DG-hCG, we have shown that removal of sugars internal to sialic acid is required to produce these specific antibodies.	N-Acetylneuraminic Acid	91-102	chorionic gonadotropin subunit beta 5	Homo sapiens	18-21
2462932-3	1988	Using hCG, asialo-hCG (A-hCG) and DG-hCG, we have shown that removal of sugars internal to sialic acid is required to produce these specific antibodies.	N-Acetylneuraminic Acid	91-102	chorionic gonadotropin subunit beta 5	Homo sapiens	18-21
2462932-3	1988	Using hCG, asialo-hCG (A-hCG) and DG-hCG, we have shown that removal of sugars internal to sialic acid is required to produce these specific antibodies.	N-Acetylneuraminic Acid	91-102	chorionic gonadotropin subunit beta 5	Homo sapiens	18-21
3131113-0	1988	Developmental aspects of the rat brain insulin receptor: loss of sialic acid and fluctuation in number characterize fetal development.	N-Acetylneuraminic Acid	65-76	insulin receptor	Rattus norvegicus	39-55
3128331-2	1988	Total removal of sialic acid diminished the haptoglobin-hemoglobin complex formation 15%.	N-Acetylneuraminic Acid	17-28	haptoglobin	Homo sapiens	44-55
3129446-1	1988	T4-binding globulin (TBG), a glycoprotein with four N-glycosyl complex oligosaccharide chains, exhibits sialic acid-dependent microheterogeneity on isoelectric focusing (IEF).	N-Acetylneuraminic Acid	104-115	serpin family A member 7	Homo sapiens	0-19
3129446-1	1988	T4-binding globulin (TBG), a glycoprotein with four N-glycosyl complex oligosaccharide chains, exhibits sialic acid-dependent microheterogeneity on isoelectric focusing (IEF).	N-Acetylneuraminic Acid	104-115	serpin family A member 7	Homo sapiens	21-24
3129446-2	1988	Increasing the sialic acid content of TBG increases its anodal IEF mobility and decreases its rate of in vivo degradation, a mechanism for the elevation of serum TBG levels in pregnancy.	N-Acetylneuraminic Acid	15-26	serpin family A member 7	Homo sapiens	38-41
3129446-2	1988	Increasing the sialic acid content of TBG increases its anodal IEF mobility and decreases its rate of in vivo degradation, a mechanism for the elevation of serum TBG levels in pregnancy.	N-Acetylneuraminic Acid	15-26	serpin family A member 7	Homo sapiens	162-165
3285099-8	1988	Pretreatment of tissue sections with neuraminidase proved that Le(x) and N-acetyllactosamine could be partly substituted by sialic acid A type 3 chain and most of N-acetyllactosamine antigens were present only in cytoplasm, whereas all other examined antigens could be present both in cytoplasm and on cell membranes.	N-Acetylneuraminic Acid	124-135	neuraminidase 1	Homo sapiens	37-50
3383434-1	1988	The carbohydrate moiety of human serum amyloid P component was analyzed and found to consist of equal amounts of galactose and mannose (total 4.0%), of glucosamine and galactosamine in a ratio of 7:1 (total 2.7%) and sialic acid (3.9%).	N-Acetylneuraminic Acid	217-228	amyloid P component, serum	Homo sapiens	33-58
3408725-4	1988	Golgi SAT was diversified in producing all the various molecular species of labeled gangliosides [2.64 pmol of NeuAc transferred (mg of protein)-1 h-1].	N-Acetylneuraminic Acid	111-116	spermidine/spermine N1-acetyltransferase family member 2	Rattus norvegicus	6-9
2834372-5	1988	These data indicate that de-N-acetylation at the sialic acid moiety of GM3 ganglioside is an important mechanism for modulation of EGF-dependent cell growth.	N-Acetylneuraminic Acid	49-60	granulocyte macrophage antigen 3	Mus musculus	71-74
2834372-5	1988	These data indicate that de-N-acetylation at the sialic acid moiety of GM3 ganglioside is an important mechanism for modulation of EGF-dependent cell growth.	N-Acetylneuraminic Acid	49-60	epidermal growth factor	Mus musculus	131-134
2451948-3	1988	Neuraminidase treatment but not tunicamycin treatment of K562 cells abolishes the expression of the GA3-epitope without affecting the L10-epitope thus providing evidence that terminal sialic acid present on O-linked oligosaccharide chains on Gp 105 is essential for the expression of the GA3-epitope.	N-Acetylneuraminic Acid	184-195	neuraminidase 1	Homo sapiens	0-13
2451948-3	1988	Neuraminidase treatment but not tunicamycin treatment of K562 cells abolishes the expression of the GA3-epitope without affecting the L10-epitope thus providing evidence that terminal sialic acid present on O-linked oligosaccharide chains on Gp 105 is essential for the expression of the GA3-epitope.	N-Acetylneuraminic Acid	184-195	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	288-291
2895745-2	1988	Erythrocyte binding assays, using whole organisms, suggested that the CFA/I receptor was a glycoprotein containing important sialic acid moieties.	N-Acetylneuraminic Acid	125-136	tubulin folding cofactor A	Homo sapiens	70-84
2966206-4	1988	Treatment of the purified receptor with neuraminidase shifted the mobility of these polypeptides to a more basic pI, ranging from 6 to 8, illustrating the presence of sialic acid residues on Fc gamma RIII.	N-Acetylneuraminic Acid	167-178	neuraminidase 1	Homo sapiens	40-53
2966206-4	1988	Treatment of the purified receptor with neuraminidase shifted the mobility of these polypeptides to a more basic pI, ranging from 6 to 8, illustrating the presence of sialic acid residues on Fc gamma RIII.	N-Acetylneuraminic Acid	167-178	Fc gamma receptor IIIa	Homo sapiens	191-204
2834727-1	1988	A unique structural feature of the neural cell adhesion molecule N-CAM is the presence of homopolymers of alpha (2----8)-linked sialic acid units.	N-Acetylneuraminic Acid	128-139	neural cell adhesion molecule 1	Homo sapiens	65-70
2834727-8	1988	We conclude that poly(sialic acid), most probably present on N-CAM, is an oncodevelopmental antigen in human kidney.	N-Acetylneuraminic Acid	22-33	neural cell adhesion molecule 1	Homo sapiens	61-66
3349104-1	1988	Sialic acid-containing storage material was isolated from cultured human mucolipidosis I (sialidosis) fibroblasts by gel permeation chromatography on Bio-Gel P-6 followed by medium-pressure anion-exchange chromatography on Mono Q.	N-Acetylneuraminic Acid	0-11	exosome component 9	Homo sapiens	158-161
3170507-7	1988	In addition, these MAbs were found to react with both GD3(NeuAc-NeuAc) and GD3(NeuGc-NeuAc), but not with GD3(NeuAc-NeuGc) or GD3(NeuGc-NeuGc).	N-Acetylneuraminic Acid	58-63	GRDX	Homo sapiens	54-57
3128350-3	1988	Under our conditions, CHO-modified vWF preparations contained less than 5% of the initial sialic acid ([Neu]-ase-vWF) and less than 45% ([Neu-Gal]-ase-vWF) or 21% ([Neu-Gal-eF]-ase-vWF) of the D-galactose.	N-Acetylneuraminic Acid	90-101	von Willebrand factor	Homo sapiens	35-38
3378240-0	1988	General methods for modification of sialic acid at C-9.	N-Acetylneuraminic Acid	36-47	complement component 9	Mus musculus	51-54
3170507-7	1988	In addition, these MAbs were found to react with both GD3(NeuAc-NeuAc) and GD3(NeuGc-NeuAc), but not with GD3(NeuAc-NeuGc) or GD3(NeuGc-NeuGc).	N-Acetylneuraminic Acid	64-69	GRDX	Homo sapiens	54-57
3170507-7	1988	In addition, these MAbs were found to react with both GD3(NeuAc-NeuAc) and GD3(NeuGc-NeuAc), but not with GD3(NeuAc-NeuGc) or GD3(NeuGc-NeuGc).	N-Acetylneuraminic Acid	64-69	GRDX	Homo sapiens	54-57
2831209-8	1988	PTH receptors on ROS 17/2.8 cells appear to be monomeric plasma membrane glycoproteins with an apparent Mr of 80,000 which contain a Mr = 59,000 polypeptide backbone and a polymeric arrangement of N-acetylglucosamine with N-acetylneuraminic acid as major terminal sugar residues.	N-Acetylneuraminic Acid	222-245	parathyroid hormone	Rattus norvegicus	0-3
3281375-6	1988	Binding activity was also reduced by pretreating cells with neuraminidase or low levels of sodium periodate, indicating that sialic acid also plays a major role in the receptor activity.	N-Acetylneuraminic Acid	125-136	neuraminidase 1	Homo sapiens	60-73
3126236-6	1988	Resting splenic B cells were unable to form specific conjugates with T cell clones, unless the B cells were first treated with neuraminidase to remove sialic acid.	N-Acetylneuraminic Acid	151-162	neuraminidase 1	Homo sapiens	127-140
3339347-6	1988	The "embryonic" form of N-CAM incorporated similar amounts of [14C]sialic acid into its constituent polypeptides reflecting the difference in sialic acid to protein ratio, as this form of N-CAM was virtually undetectable in the immunoblots of postnatal material.	N-Acetylneuraminic Acid	67-78	neural cell adhesion molecule 1	Rattus norvegicus	24-29
3346542-8	1988	These results establish the ability of sialic acid on glycolipids to promote H binding to C3b and thereby regulate alternative pathway activation on a defined lipid membrane.	N-Acetylneuraminic Acid	39-50	complement C3	Homo sapiens	90-93
3346214-4	1988	All sugar chains of erythropoietin produced by recombinant Chinese hamster ovary cells contain only the NeuAc alpha 2----3Gal linkage, while those of human urinary erythropoietin contain the NeuAc alpha 2----6Gal linkage together with the NeuAc alpha 2----3Gal linkage.	N-Acetylneuraminic Acid	104-109	erythropoietin	Cricetulus griseus	20-34
3346214-4	1988	All sugar chains of erythropoietin produced by recombinant Chinese hamster ovary cells contain only the NeuAc alpha 2----3Gal linkage, while those of human urinary erythropoietin contain the NeuAc alpha 2----6Gal linkage together with the NeuAc alpha 2----3Gal linkage.	N-Acetylneuraminic Acid	191-196	erythropoietin	Cricetulus griseus	20-34
2449438-13	1988	Elimination of sialic acid slightly increased the activity, and subsequent elimination of galactose did not alter the activity; however, removal of the Gal beta 1----3GalNAc residue by endo-alpha-N-acetylgalactosaminidase from desialylated glycopeptide A resulted in total inactivation of the reactivity with FDC-6 antibody.	N-Acetylneuraminic Acid	15-26	alpha-N-acetylgalactosaminidase	Homo sapiens	190-221
3370722-5	1988	Laser-light scattering measurements show that GM1(NeuGc) aggregates in aqueous media being present in solution as micelles with a molecular weight of 576,000 and a hydrodynamic radius of 62.4 A as determined at 25 degrees C. GM1(NeuGc) promotes neurite outgrowth in N-2a cells to a similar degree as GM1(NeuAc), but shows different behaviour under treatment with sialidase from Arthrobacter ureafaciens.	N-Acetylneuraminic Acid	304-309	coenzyme Q10A	Mus musculus	46-56
3370722-5	1988	Laser-light scattering measurements show that GM1(NeuGc) aggregates in aqueous media being present in solution as micelles with a molecular weight of 576,000 and a hydrodynamic radius of 62.4 A as determined at 25 degrees C. GM1(NeuGc) promotes neurite outgrowth in N-2a cells to a similar degree as GM1(NeuAc), but shows different behaviour under treatment with sialidase from Arthrobacter ureafaciens.	N-Acetylneuraminic Acid	304-309	coenzyme Q10A	Mus musculus	225-235
2980786-1	1988	After removal of more than 70% of the sialic acid from the erythrocyte membrane by treatment with neuraminidase, trifluoperazine (TFP) increased the rapid and slow phase of 45Ca2+ uptake into erythrocytes, identically to Ca2+ uptake into untreated erythrocytes from patients with tetanic syndrome.	N-Acetylneuraminic Acid	38-49	neuraminidase 1	Homo sapiens	98-111
3339347-6	1988	The "embryonic" form of N-CAM incorporated similar amounts of [14C]sialic acid into its constituent polypeptides reflecting the difference in sialic acid to protein ratio, as this form of N-CAM was virtually undetectable in the immunoblots of postnatal material.	N-Acetylneuraminic Acid	142-153	neural cell adhesion molecule 1	Rattus norvegicus	24-29
3359653-3	1988	In the patients, significant reductions of the sialic acid concentration were found in the aqueous phase (p = 0.03) containing mainly glycophorin A as well as in the band-3-containing interphase (p less than 0.005).	N-Acetylneuraminic Acid	47-58	glycophorin A (MNS blood group)	Homo sapiens	134-147
3339017-4	1988	These analyses indicated that terminal sialic acid residues and Asn-linked oligosaccharides were present on both subunits of ABP from the two sources.	N-Acetylneuraminic Acid	39-50	sex hormone binding globulin	Homo sapiens	125-128
3257635-5	1988	For staining of histiocytosis X cells, unlike Reed-Sternberg cells in Hodgkin"s disease, neuraminidase treatment was required for removal of sialic acid residues from the Leu-M1 antigen.	N-Acetylneuraminic Acid	141-152	neuraminidase 1	Homo sapiens	89-102
2449496-6	1988	This reactivity was significantly increased upon removal of sialic acid residues by neuraminidase.	N-Acetylneuraminic Acid	60-71	neuraminidase 1	Homo sapiens	84-97
2834294-0	1988	Selective spin-labelling of an N-acetylneuraminic acid residue in the Fab-region oligosaccharide of immunoglobulin M. A method is proposed for spin-labelling using 2,2,6,6-tetramethyl-4-aminopiperidine-1-oxyl, the N-acetylneuraminic acid residue within the Fab-region oligosaccharide of immunoglobulin M (IgM).	N-Acetylneuraminic Acid	31-54	FA complementation group B	Homo sapiens	70-73
2834294-0	1988	Selective spin-labelling of an N-acetylneuraminic acid residue in the Fab-region oligosaccharide of immunoglobulin M. A method is proposed for spin-labelling using 2,2,6,6-tetramethyl-4-aminopiperidine-1-oxyl, the N-acetylneuraminic acid residue within the Fab-region oligosaccharide of immunoglobulin M (IgM).	N-Acetylneuraminic Acid	31-54	FA complementation group B	Homo sapiens	257-260
2834294-0	1988	Selective spin-labelling of an N-acetylneuraminic acid residue in the Fab-region oligosaccharide of immunoglobulin M. A method is proposed for spin-labelling using 2,2,6,6-tetramethyl-4-aminopiperidine-1-oxyl, the N-acetylneuraminic acid residue within the Fab-region oligosaccharide of immunoglobulin M (IgM).	N-Acetylneuraminic Acid	214-237	FA complementation group B	Homo sapiens	70-73
2449128-7	1988	MAb R24 was found to react with (NeuAc-NeuAc-)GD3 and (NeuAc-NeuGc-)GD3 but not with (NeuGc-NeuAc-)GD3 or (NeuGc-NeuGc-)GD3.	N-Acetylneuraminic Acid	33-38	GRDX	Homo sapiens	46-49
3339096-7	1988	Sequence analysis shows that it codes for mouse osteopontin, an RGDS-containing, phosphorylated, sialic acid-rich Ca++-binding protein originally isolated from bone (Oldberg, A., A. Franzen, and D. Heinegard.	N-Acetylneuraminic Acid	97-108	secreted phosphoprotein 1	Mus musculus	48-59
3349045-8	1988	The concentration of ganglioside sialic acid was approximately 0.34 and 0.18 microgram/mg of protein for cells grown in the presence and absence of NGF, respectively.	N-Acetylneuraminic Acid	33-44	nerve growth factor	Rattus norvegicus	148-151
2961812-7	1988	The mechanism by which neuraminidase treatment enhances B cell APC function was further investigated by studying the effect of sialic acid removal on a primary mixed leukocyte reaction (MLR).	N-Acetylneuraminic Acid	127-138	neuraminidase 1	Homo sapiens	23-36
2449128-8	1988	These results clearly indicate that the outer sialic acid (Sia) moiety of GD3 is crucial and must be a NeuAc residue, while the inner sialic acid is less involved in binding to the MAb and can be either NeuAc or NeuGc.	N-Acetylneuraminic Acid	46-57	GRDX	Homo sapiens	74-77
2449128-8	1988	These results clearly indicate that the outer sialic acid (Sia) moiety of GD3 is crucial and must be a NeuAc residue, while the inner sialic acid is less involved in binding to the MAb and can be either NeuAc or NeuGc.	N-Acetylneuraminic Acid	59-62	GRDX	Homo sapiens	74-77
2449128-8	1988	These results clearly indicate that the outer sialic acid (Sia) moiety of GD3 is crucial and must be a NeuAc residue, while the inner sialic acid is less involved in binding to the MAb and can be either NeuAc or NeuGc.	N-Acetylneuraminic Acid	103-108	GRDX	Homo sapiens	74-77
2449128-8	1988	These results clearly indicate that the outer sialic acid (Sia) moiety of GD3 is crucial and must be a NeuAc residue, while the inner sialic acid is less involved in binding to the MAb and can be either NeuAc or NeuGc.	N-Acetylneuraminic Acid	134-145	GRDX	Homo sapiens	74-77
2449128-8	1988	These results clearly indicate that the outer sialic acid (Sia) moiety of GD3 is crucial and must be a NeuAc residue, while the inner sialic acid is less involved in binding to the MAb and can be either NeuAc or NeuGc.	N-Acetylneuraminic Acid	203-208	GRDX	Homo sapiens	74-77
3147726-6	1988	Two forms of native LIF, distinguishable by their chromatographic behavior on DEAE-Sepharose, were converted by neuraminidase treatment to a form with similar chromatographic behavior, suggesting that the major difference between these two species is the content of sialic acid on the carbohydrate portion.	N-Acetylneuraminic Acid	266-277	leukemia inhibitory factor	Mus musculus	20-23
2467832-4	1988	Most of the anti-CD43 mAbs recognize sialic acid-dependent epitopes.	N-Acetylneuraminic Acid	37-48	sialophorin	Homo sapiens	17-21
3278802-5	1988	Furthermore, treatment of the cells with neuraminidase partly restored the expression of monomorphic HLA-A,B,C suggesting that at least some of the observed quantitative differences could be due to masking of the membrane bound HLA antigens by sialic acid-containing glycoconjugates.	N-Acetylneuraminic Acid	244-255	neuraminidase 1	Homo sapiens	41-54
3278802-5	1988	Furthermore, treatment of the cells with neuraminidase partly restored the expression of monomorphic HLA-A,B,C suggesting that at least some of the observed quantitative differences could be due to masking of the membrane bound HLA antigens by sialic acid-containing glycoconjugates.	N-Acetylneuraminic Acid	244-255	major histocompatibility complex, class I, A	Homo sapiens	101-108
3356296-7	1988	Removal of sialic acid from oligosaccharide chains of haptoglobin made the molecule more accessible to diazotized sulfanilic acid.	N-Acetylneuraminic Acid	11-22	haptoglobin	Homo sapiens	54-65
2896177-1	1988	Sialic acid (SA) has been estimated in human spermatozoa separated according to age by the use of a discontinuous gradient of human serum albumin (HSA), and according to quality (viability and motility) by the use of a discontinuous gradient of bovine serum albumin (BSA).	N-Acetylneuraminic Acid	0-11	albumin	Homo sapiens	132-145
3280426-8	1988	Two types of Glu-plasminogen occur in human plasma, which differ in their carbohydrate composition as well as in their content of sialic acid.	N-Acetylneuraminic Acid	130-141	plasminogen	Homo sapiens	17-28
3360761-9	1988	Secondly, marked polymorphic variation was found in the expression of GM4(NeuAc) in the erythrocytes.	N-Acetylneuraminic Acid	74-79	T cell receptor alpha variable 6-3	Mus musculus	70-73
3356297-2	1988	Human haptoglobin (Hp) type 2-1 was subjected to the sulfanilazo-modification of tyrosine and histidine residues, the removal of sialic acid, and the reduction of disulfide bonds (isolation of alpha 2, alpha 1, beta subunits), respectively.	N-Acetylneuraminic Acid	129-140	haptoglobin	Homo sapiens	6-17
2897688-1	1988	Two types of pancreatic gamma-glutamyltranspeptidase (GGTP) (EC 2.3.2.2), sialic acid poor and sialic acid rich, were purified by the following: anion-exchange chromatography, wheat germ agglutinin (WGA)-Sepharose chromatography, gel filtration chromatography, phenyl-Superose chromatography, and hydroxylapatite chromatography.	N-Acetylneuraminic Acid	74-85	inactive glutathione hydrolase 2	Homo sapiens	54-58
2447219-7	1988	Sialic acid was essential for CT antigen expression since neuraminidase or mild periodate treatment abrogated CT antibody binding.	N-Acetylneuraminic Acid	0-11	neuraminidase 1	Homo sapiens	58-71
2897688-1	1988	Two types of pancreatic gamma-glutamyltranspeptidase (GGTP) (EC 2.3.2.2), sialic acid poor and sialic acid rich, were purified by the following: anion-exchange chromatography, wheat germ agglutinin (WGA)-Sepharose chromatography, gel filtration chromatography, phenyl-Superose chromatography, and hydroxylapatite chromatography.	N-Acetylneuraminic Acid	95-106	inactive glutathione hydrolase 2	Homo sapiens	54-58
2897688-4	1988	Sialic acid-rich GGTP had two subunits of Mr 67,000 and 27,000; however, the sialic acid-poor type had two subunits of Mr 72,000 and 29,000.	N-Acetylneuraminic Acid	0-11	inactive glutathione hydrolase 2	Homo sapiens	17-21
3354262-7	1988	The sialic acid content was lower in ewe"s and goat"s milk (2.68 and 2.98 mg/100 mg protein respectively) than in bovine milk (2.06 mg/100 mg protein).	N-Acetylneuraminic Acid	4-15	Weaning weight-maternal milk	Bos taurus	54-58
2897688-5	1988	The pI value of the sialic acid-poor GGTP was 5.9, and that of the sialic acid-rich GGTP 3.6.	N-Acetylneuraminic Acid	20-31	inactive glutathione hydrolase 2	Homo sapiens	37-41
2897688-5	1988	The pI value of the sialic acid-poor GGTP was 5.9, and that of the sialic acid-rich GGTP 3.6.	N-Acetylneuraminic Acid	67-78	inactive glutathione hydrolase 2	Homo sapiens	84-88
3123586-2	1987	The apoC-III polypeptide contains a carbohydrate chain containing galactosamine, galactose, and sialic acid attached in O-linkage to a threonine residue at position 74.	N-Acetylneuraminic Acid	96-107	apolipoprotein C3	Homo sapiens	4-12
3692625-8	1987	The finding that mucin, but not asialomucin, inhibits the reaction, demonstrates the importance of sialic acid in this process.	N-Acetylneuraminic Acid	99-110	LOC100508689	Homo sapiens	17-22
3445822-5	1987	Removal of the negatively charged sialic acid from the cell surface by neuraminidase did not affect the the action of the crystals.	N-Acetylneuraminic Acid	34-45	neuraminidase 1	Homo sapiens	71-84
3316217-0	1987	Cholesteryl ester transfer protein is secreted by Hep G2 cells and contains asparagine-linked carbohydrate and sialic acid.	N-Acetylneuraminic Acid	111-122	cholesteryl ester transfer protein	Homo sapiens	0-34
3316217-7	1987	The CETP peptide acquires asparagine-linked carbohydrate and sialic acid during intracellular processing.	N-Acetylneuraminic Acid	61-72	cholesteryl ester transfer protein	Homo sapiens	4-8
2448402-5	1987	After treatment with sialidase, both hCG alpha and PU alpha were shifted to the basic region, indicating that they contained terminal sialic acid residues.	N-Acetylneuraminic Acid	134-145	chorionic gonadotropin subunit beta 5	Homo sapiens	37-40
2960731-6	1987	CD4 modulation appeared to be a general property of gangliosides since the effect could be induced similarly by highly purified individual gangliosides with varying amounts of sialic acid, or by mixed gangliosides.	N-Acetylneuraminic Acid	176-187	Cd4 molecule	Rattus norvegicus	0-3
2827918-0	1987	Loss of sialic acid from 5"-nucleotidase in human milk.	N-Acetylneuraminic Acid	8-19	5'-nucleotidase ecto	Homo sapiens	25-40
3674885-1	1987	A high-molecular-weight mucin-glycoprotein (MG1) was isolated from human submandibular-sublingual saliva and was comprised of 14.9% protein, 29.0% N-acetylglucosamine, 9.4% N-acetylgalactosamine, 10.5% fucose, 24.2% galactose, 0.9% mannose, 4.0% N-acetylneuraminic acid, and 7.0% sulfate.	N-Acetylneuraminic Acid	246-269	LOC100508689	Homo sapiens	24-29
3427589-4	1987	The value of the method for preparative purposes was demonstrated for sialic acid-containing carbohydrates obtained from human serotransferrin by hydrazinolysis.	N-Acetylneuraminic Acid	70-81	transferrin	Homo sapiens	127-142
3663669-3	1987	Using two different preparations of neuraminidase, we performed a sialic acid depletion on the youngest erythrocytes to reach a sialic acid content similar to that observed in physiologically aged erythrocytes.	N-Acetylneuraminic Acid	66-77	neuraminidase 1	Homo sapiens	36-49
3665935-1	1987	In this report several NeuAc analogues differently modified at position C-9 were tested as substrates for CMP sialic acid synthase from bovine brain: the hydroxy group at C-9 was replaced by an amino, acetamido, benzamido, hexanoylamido and azido group.	N-Acetylneuraminic Acid	23-28	complement C9	Bos taurus	72-75
3665935-1	1987	In this report several NeuAc analogues differently modified at position C-9 were tested as substrates for CMP sialic acid synthase from bovine brain: the hydroxy group at C-9 was replaced by an amino, acetamido, benzamido, hexanoylamido and azido group.	N-Acetylneuraminic Acid	23-28	N-acetylneuraminate synthase	Bos taurus	110-130
3665935-1	1987	In this report several NeuAc analogues differently modified at position C-9 were tested as substrates for CMP sialic acid synthase from bovine brain: the hydroxy group at C-9 was replaced by an amino, acetamido, benzamido, hexanoylamido and azido group.	N-Acetylneuraminic Acid	23-28	complement C9	Bos taurus	171-174
3674885-1	1987	A high-molecular-weight mucin-glycoprotein (MG1) was isolated from human submandibular-sublingual saliva and was comprised of 14.9% protein, 29.0% N-acetylglucosamine, 9.4% N-acetylgalactosamine, 10.5% fucose, 24.2% galactose, 0.9% mannose, 4.0% N-acetylneuraminic acid, and 7.0% sulfate.	N-Acetylneuraminic Acid	246-269	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	44-47
2446045-3	1987	Two of the MAbs, designated Mu-2 and Mu-4, recognized a CSAp determinant containing sialic acid, and this epitope was also expressed on bovine submaxillary mucin (BSM).	N-Acetylneuraminic Acid	84-95	adaptor related protein complex 1 subunit mu 2	Homo sapiens	28-32
2446045-3	1987	Two of the MAbs, designated Mu-2 and Mu-4, recognized a CSAp determinant containing sialic acid, and this epitope was also expressed on bovine submaxillary mucin (BSM).	N-Acetylneuraminic Acid	84-95	adaptor related protein complex 4 subunit mu 1	Bos taurus	37-41
2446045-3	1987	Two of the MAbs, designated Mu-2 and Mu-4, recognized a CSAp determinant containing sialic acid, and this epitope was also expressed on bovine submaxillary mucin (BSM).	N-Acetylneuraminic Acid	84-95	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	56-60
2824978-5	1987	Removal of terminal sialic acid residues by neuraminidase decreased the receptor Mr by 6,000; however, alpha-mannosidase was without effect, indicating complex type glycosylation of the receptor-protein.	N-Acetylneuraminic Acid	20-31	neuraminidase 1	Homo sapiens	44-57
3663654-8	1987	The biological responsiveness to the viruses of the erythrocytes labeled with the derivatized glycoprotein 2 containing NeuGc was considerably lower than that of derivatized glycoprotein 2 containing NeuAc.	N-Acetylneuraminic Acid	200-205	glycoprotein 2	Homo sapiens	174-188
3667593-5	1987	NeuAc, which is alpha 2-3-linked to galactose in the human IFN-beta secreted by Chinese hamster ovary cells, can be re-incorporated with an alpha 2-6 linkage in vitro, into enzymatically desialylated IFN-beta using rat liver Gal beta 1-4GlcNAc alpha 2-6 sialyltransferase.	N-Acetylneuraminic Acid	0-5	interferon beta 1	Homo sapiens	59-67
3667593-5	1987	NeuAc, which is alpha 2-3-linked to galactose in the human IFN-beta secreted by Chinese hamster ovary cells, can be re-incorporated with an alpha 2-6 linkage in vitro, into enzymatically desialylated IFN-beta using rat liver Gal beta 1-4GlcNAc alpha 2-6 sialyltransferase.	N-Acetylneuraminic Acid	0-5	interferon beta 1	Homo sapiens	200-208
3661561-4	1987	HPX reveals extensive microheterogeneity with multiple major and minor components that are susceptible to neuraminidase treatment, suggesting that the observed biochemical variation is due to differences in sialic acid content between HPX isoproteins.	N-Acetylneuraminic Acid	207-218	hemopexin	Homo sapiens	0-3
3314559-10	1987	Successive loss of sialic acid is compatible with the presence of different transferrin forms, and our results indicate that the main differences between the serum transferrin forms from healthy and alcoholic individuals are in successive changes of the carbohydrate chains attached at positions 413 and 611.	N-Acetylneuraminic Acid	19-30	transferrin	Homo sapiens	76-87
3661561-4	1987	HPX reveals extensive microheterogeneity with multiple major and minor components that are susceptible to neuraminidase treatment, suggesting that the observed biochemical variation is due to differences in sialic acid content between HPX isoproteins.	N-Acetylneuraminic Acid	207-218	neuraminidase 1	Homo sapiens	106-119
3661561-4	1987	HPX reveals extensive microheterogeneity with multiple major and minor components that are susceptible to neuraminidase treatment, suggesting that the observed biochemical variation is due to differences in sialic acid content between HPX isoproteins.	N-Acetylneuraminic Acid	207-218	hemopexin	Homo sapiens	235-238
3116030-1	1987	Hyperestrogenemic states, including pregnancy, cause an increase in serum T4-binding globulin (TBG) concentrations and an increase in the proportion of TBG molecules with greater anodal mobility on isoelectric focusing, indicating greater sialic acid content.	N-Acetylneuraminic Acid	239-250	serpin family A member 7	Homo sapiens	152-155
3115896-6	1987	The level of free sialic acid released by endogenous neuraminidase was higher in the saliva from CF patients than in that from the non-CF subjects examined.	N-Acetylneuraminic Acid	18-29	neuraminidase 1	Homo sapiens	53-66
3426806-4	1987	NeuAc residue(s), probably representing part(s) of a carbohydrate unit attached to serine42 of glycophorin C, methionine, aspartic or glutamic acid, tryptophan and/or arginine residue(s) are involved in the Ge3 epitopes, as judged from chemical modification.	N-Acetylneuraminic Acid	0-5	glycophorin C (Gerbich blood group)	Homo sapiens	95-108
2446768-6	1987	(4) Sialic acid is a major surface charge component of the cells as evidenced by a dramatic drop in their partition ratios after treatment with neuraminidase.	N-Acetylneuraminic Acid	4-15	neuraminidase 1	Homo sapiens	144-157
2958268-1	1987	The binding subunits of the insulin and insulin-like growth factor-I (IGF I) receptors from rat brain are of lower molecular weight than the corresponding receptor in rat liver, possibly due to variations in sialic acid content.	N-Acetylneuraminic Acid	208-219	insulin-like growth factor 1	Rattus norvegicus	40-68
2958268-1	1987	The binding subunits of the insulin and insulin-like growth factor-I (IGF I) receptors from rat brain are of lower molecular weight than the corresponding receptor in rat liver, possibly due to variations in sialic acid content.	N-Acetylneuraminic Acid	208-219	insulin-like growth factor 1	Rattus norvegicus	70-75
3116030-12	1987	These results indicate that the rate of in vivo metabolism of TBG is dependent on its sialic acid content.	N-Acetylneuraminic Acid	86-97	serpin family A member 7	Homo sapiens	62-65
3116030-13	1987	The increased proportion of TBG molecules with higher sialic acid content thus contributes to the increase in the serum TBG concentration in hyperestrogenemic states.	N-Acetylneuraminic Acid	54-65	serpin family A member 7	Homo sapiens	28-31
3116030-13	1987	The increased proportion of TBG molecules with higher sialic acid content thus contributes to the increase in the serum TBG concentration in hyperestrogenemic states.	N-Acetylneuraminic Acid	54-65	serpin family A member 7	Homo sapiens	120-123
2442170-12	1987	These results suggest that both protein components and sialic acid residues may play important roles in the binding of DU-PAN-2 antibody.	N-Acetylneuraminic Acid	55-66	poly(A) specific ribonuclease subunit PAN2	Homo sapiens	122-127
3478423-1	1987	Transferrin is a serum glycoprotein which contains four sialic acid residues located at the end of two branched carbohydrate structures.	N-Acetylneuraminic Acid	56-67	transferrin	Homo sapiens	0-11
3624248-9	1987	alpha 2----3-Linked sialic acid and N-acetyllactosaminyl repeats are selectively present in the side chains attached to C-6 and C-2 of 2,6-substituted alpha-mannose and C-4 of 2,4-substituted alpha-mannose.	N-Acetylneuraminic Acid	20-31	complement C6	Homo sapiens	120-123
3624248-9	1987	alpha 2----3-Linked sialic acid and N-acetyllactosaminyl repeats are selectively present in the side chains attached to C-6 and C-2 of 2,6-substituted alpha-mannose and C-4 of 2,4-substituted alpha-mannose.	N-Acetylneuraminic Acid	20-31	complement C2	Homo sapiens	128-131
3624248-9	1987	alpha 2----3-Linked sialic acid and N-acetyllactosaminyl repeats are selectively present in the side chains attached to C-6 and C-2 of 2,6-substituted alpha-mannose and C-4 of 2,4-substituted alpha-mannose.	N-Acetylneuraminic Acid	20-31	complement C4A (Rodgers blood group)	Homo sapiens	169-172
3478423-6	1987	These experiments support the hypothesis that the "ladder" banding pattern of transferrin observed in some case samples is due to the removal of sialic acid residues by bacterial or endogenous neuraminidase.	N-Acetylneuraminic Acid	145-156	transferrin	Homo sapiens	78-89
3478423-6	1987	These experiments support the hypothesis that the "ladder" banding pattern of transferrin observed in some case samples is due to the removal of sialic acid residues by bacterial or endogenous neuraminidase.	N-Acetylneuraminic Acid	145-156	neuraminidase 1	Homo sapiens	193-206
3478423-7	1987	These studies also demonstrate that partially desialidated transferrin variants cannot be clearly typed until the sialic acid is completely stripped from the transferrin molecule.	N-Acetylneuraminic Acid	114-125	transferrin	Homo sapiens	59-70
3611111-10	1987	When sufficient sialic acid is present in the oligosaccharides, native highly viscous mucin containing about two-thirds carbohydrate by weight is obtained.	N-Acetylneuraminic Acid	16-27	LOC100508689	Homo sapiens	86-91
3621302-6	1987	Pretreatment with neuraminidase to remove sialic acid resulted in increased binding of RCAI and PNA, which now labeled both rods and cones, and in decreased binding of WGA.	N-Acetylneuraminic Acid	42-53	neuraminidase 1	Homo sapiens	18-31
3475717-5	1987	These findings suggest that changes in sialic acid are a fundamental aspect of the function of NCAM in development, whereas NCAM polypeptide differences may affect events associated with a particular vertebrate.	N-Acetylneuraminic Acid	39-50	neural cell adhesion molecule 1	Gallus gallus	95-99
3038958-0	1987	Type IIB von Willebrand factor with normal sialic acid content induces platelet aggregation in the absence of ristocetin.	N-Acetylneuraminic Acid	43-54	von Willebrand factor	Homo sapiens	9-30
3475717-6	1987	Studies have demonstrated that a decreased sialic acid content enhances the adhesion properties of NCAM.	N-Acetylneuraminic Acid	43-54	neural cell adhesion molecule 1	Gallus gallus	99-103
3678558-7	1987	A relative lack of surface sialic acid has been found to be important for binding complement Factor B of the ACP by susceptible microbial surfaces.	N-Acetylneuraminic Acid	27-38	complement factor B	Ictalurus punctatus	82-101
3301866-5	1987	Although excluded from the trans-side of the Golgi system, where sialylation is believed to occur, GIMPc acquires sialic acid in both its N- and O-linked carbohydrates.	N-Acetylneuraminic Acid	114-125	golgi integral membrane protein 4	Homo sapiens	99-104
3036467-1	1987	The present studies were undertaken to delineate the role of sialic acid residues in the two subunits of hCG in relation to its hormonal activity.	N-Acetylneuraminic Acid	61-72	chorionic gonadotropin subunit beta 5	Homo sapiens	105-108
3036467-2	1987	Sialic acid was removed by treatment of the individual subunits or intact hCG with insolubilized neuraminidase.	N-Acetylneuraminic Acid	0-11	chorionic gonadotropin subunit beta 5	Homo sapiens	74-77
3036467-2	1987	Sialic acid was removed by treatment of the individual subunits or intact hCG with insolubilized neuraminidase.	N-Acetylneuraminic Acid	0-11	neuraminidase 1	Homo sapiens	97-110
3036467-7	1987	In a TSH receptor assay in human thyroid membranes, loss of sialic acid from either one or both hCG subunits resulted in enhancement of binding affinity; the rank order of decreasing potency was asialo-hCG, alpha-as beta, as alpha-beta.	N-Acetylneuraminic Acid	60-71	chorionic gonadotropin subunit beta 5	Homo sapiens	96-99
3036467-12	1987	In all cases, sialic acid in the beta-subunit of hCG appears to have a predominant role in these effects.	N-Acetylneuraminic Acid	14-25	chorionic gonadotropin subunit beta 5	Homo sapiens	49-52
3115291-2	1987	Sialophorin is greater than 50% carbohydrate, primarily O-linked units of sialic acid, galactose, and galactosamine.	N-Acetylneuraminic Acid	74-85	sialophorin	Homo sapiens	0-11
3037009-7	1987	Treatment of glycophorin with neuraminidase prevented it binding to EMC virus-Sepharose indicating the requirement for sialic acid for receptor activity.	N-Acetylneuraminic Acid	119-130	neuraminidase 1	Homo sapiens	30-43
3471317-5	1987	Product identification by high performance liquid chromatography showed that enzyme from both normal and CML granulocytes linked sialic acid to galactosyl-beta 1-3-N-acetyl-D-galactosamine-R by the alpha(2-3) and not the alpha(2-6) linkage.	N-Acetylneuraminic Acid	129-140	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	155-163
3115247-5	1987	These proteins, in particular the principal gamma-chain (p32) become the target of extensive posttranslational modification by sialic acid.	N-Acetylneuraminic Acid	127-138	inhibitor of growth family member 2	Homo sapiens	57-60
3573143-3	1987	Using a solid-phase binding assay, we further demonstrated that the ability of reovirus type 3 or reassortant 1HA3 and the inability of reovirus type 1 or reassortant 3HA1 to bind avidly to BSM was a property of the viral S1 genome segment and required the presence of sialic acid residues on BSM oligosaccharides.	N-Acetylneuraminic Acid	269-280	mucin-19	Bos taurus	190-193
3567224-1	1987	Using bovine mucin and isolated human myelin as sources of sialic acid, we demonstrate the presence of neuraminidase activities in the growth media of pathogenic, but not nonpathogenic, Naegleria sp.	N-Acetylneuraminic Acid	59-70	neuraminidase 1	Homo sapiens	103-116
3567224-3	1987	Neuraminidase activity was maximal at pH 4.5 and 5.0, and the specific activity for sialic acid release was up to 13-fold greater with mucin than with human myelin.	N-Acetylneuraminic Acid	84-95	neuraminidase 1	Homo sapiens	0-13
3567224-3	1987	Neuraminidase activity was maximal at pH 4.5 and 5.0, and the specific activity for sialic acid release was up to 13-fold greater with mucin than with human myelin.	N-Acetylneuraminic Acid	84-95	LOC100508689	Homo sapiens	135-140
3654592-4	1987	The enzyme liberated the sialic acid residues from (alpha 2-3) and (alpha 2-6) sialyllactose, colomic acid, fetuin, and transferrin, but not from bovine submaxillary mucin.	N-Acetylneuraminic Acid	25-36	serotransferrin	Bos taurus	120-131
3559563-4	1987	In 12-day-old animals the majority of the transferred [14C]sialic acid was found to be associated with the high-molecular-weight [greater than 200 kilodaltons (kd)] form of D2-CAM/N-CAM, indicative of the protein having been heavily sialylated.	N-Acetylneuraminic Acid	59-70	calmodulin 1	Rattus norvegicus	176-179
3559563-4	1987	In 12-day-old animals the majority of the transferred [14C]sialic acid was found to be associated with the high-molecular-weight [greater than 200 kilodaltons (kd)] form of D2-CAM/N-CAM, indicative of the protein having been heavily sialylated.	N-Acetylneuraminic Acid	59-70	neural cell adhesion molecule 1	Rattus norvegicus	180-185
3596002-6	1987	Treatment of these N-acetylneuraminic acid (NeuNAc)-free forms with renin leads to a shift of these double bands to a more acid pH, indicating heterogeneity within the protein structure.	N-Acetylneuraminic Acid	19-42	renin	Rattus norvegicus	68-73
3596002-6	1987	Treatment of these N-acetylneuraminic acid (NeuNAc)-free forms with renin leads to a shift of these double bands to a more acid pH, indicating heterogeneity within the protein structure.	N-Acetylneuraminic Acid	44-50	renin	Rattus norvegicus	68-73
3567932-5	1987	This cell-cell interaction mediated by p55 results in the incorporation of sialic acid into lymphocyte surface asialo-glycans.	N-Acetylneuraminic Acid	75-86	MAGUK p55 scaffold protein 1	Rattus norvegicus	39-42
3573143-5	1987	Interaction of reovirus type 3 with sialylated oligosaccharides of BSM is dramatically affected by the degree of O-acetylation of their sialic acid residues, as indicated by the findings that chemical removal of O-acetyl groups stimulated reovirus type 3 attachment to BSM, whereas preferential removal of residues lacking or possessing reduced amounts of O-acetyl groups per sialic acid molecule with Vibrio cholerae sialidase abolished binding.	N-Acetylneuraminic Acid	136-147	mucin-19	Bos taurus	67-70
3573143-5	1987	Interaction of reovirus type 3 with sialylated oligosaccharides of BSM is dramatically affected by the degree of O-acetylation of their sialic acid residues, as indicated by the findings that chemical removal of O-acetyl groups stimulated reovirus type 3 attachment to BSM, whereas preferential removal of residues lacking or possessing reduced amounts of O-acetyl groups per sialic acid molecule with Vibrio cholerae sialidase abolished binding.	N-Acetylneuraminic Acid	376-387	mucin-19	Bos taurus	67-70
3594474-0	1987	On the side-chain conformation of N-acetylneuraminic acid and its epimers at C-7, C-8, and C-7,8.	N-Acetylneuraminic Acid	34-57	complement C7	Homo sapiens	77-80
3594474-0	1987	On the side-chain conformation of N-acetylneuraminic acid and its epimers at C-7, C-8, and C-7,8.	N-Acetylneuraminic Acid	34-57	homeobox C8	Homo sapiens	82-85
3594474-0	1987	On the side-chain conformation of N-acetylneuraminic acid and its epimers at C-7, C-8, and C-7,8.	N-Acetylneuraminic Acid	34-57	complement C7	Homo sapiens	91-94
3577588-12	1987	From this it is concluded that in the intact LH molecule, some sialic acid residues are poorer substrates for neuraminidase action than in the free subunits.	N-Acetylneuraminic Acid	63-74	neuraminidase 1	Homo sapiens	110-123
2440260-2	1987	Enzymatical removal of sialic acid enhanced histamine release induced by allergen and anti-IgE, whereas an increase in membrane sialic acid content by insertion of sialic acid containing gangliosides into the membrane inhibited the mediator release.	N-Acetylneuraminic Acid	23-34	immunoglobulin heavy constant epsilon	Homo sapiens	91-94
3595757-2	1987	A lectin which binds to both sialic acid and N-acetylglucosamine sugar residues, wheat germ agglutinin-ferritin (WGA-fe), was used.	N-Acetylneuraminic Acid	29-40	Fer2	Triticum aestivum	103-111
3473973-2	1987	Total and neuraminidase-sensitive sialic acid are enhanced 3 to 4 times when expressed per 10(6) cells.	N-Acetylneuraminic Acid	34-45	neuraminidase 1	Homo sapiens	10-23
3470114-3	1987	We have now observed in these same plasma samples that the concentrations of lipid-associated sialic acid (LAS) are also inversely correlated with the ALF activities and, therefore, directly correlated with ovarian cancer susceptibility.	N-Acetylneuraminic Acid	94-105	general transcription factor IIA subunit 1 like	Homo sapiens	151-154
3496105-7	1987	The carbohydrate content (sialic acid, sulphate groups, N-acetylglucosamine, N-acetylgalactosamine) was also determined, and it shows that CSF is a glycoprotein.	N-Acetylneuraminic Acid	26-37	colony stimulating factor 2	Homo sapiens	139-142
3036083-11	1987	The presence of sialic acid on the major VIP-binding protein was demonstrated after treatment of intact cells with neuraminidase or by chemical desialylation with hydrochloric acid.	N-Acetylneuraminic Acid	16-27	vasoactive intestinal peptide	Homo sapiens	41-44
3816803-6	1987	By contrast to colligin, SPARC secreted by PYS cells contains predominantly a diantennary complex type of chain containing a variable number of sialic acid and core-substituted fucose residues.	N-Acetylneuraminic Acid	144-155	secreted acidic cysteine rich glycoprotein	Mus musculus	25-30
2954261-10	1987	Sialic acid content was markedly decreased in fibrinogen Barcelona.	N-Acetylneuraminic Acid	0-11	fibrinogen beta chain	Homo sapiens	46-56
3026609-6	1987	The finding that these highly acidic components can be converted to molecules with an alkaline pI by neuraminidase digestion suggests that this high negative charge may be due to an increased sialic acid content.	N-Acetylneuraminic Acid	192-203	neuraminidase 1	Homo sapiens	101-114
3036083-11	1987	The presence of sialic acid on the major VIP-binding protein was demonstrated after treatment of intact cells with neuraminidase or by chemical desialylation with hydrochloric acid.	N-Acetylneuraminic Acid	16-27	neuraminidase 1	Homo sapiens	115-128
3036083-12	1987	We conclude from this study that the VIP receptor from intact HT29-D4 cells is a glycoprotein with N-linked oligosaccharide side chains containing sialic acid.	N-Acetylneuraminic Acid	147-158	vasoactive intestinal peptide	Homo sapiens	37-40
2437241-2	1987	Owing to its low content of sialic acid, beta 2-transferrin migrates more slowly than the main transferrin component (beta 1-transferrin) in electrophoresis.	N-Acetylneuraminic Acid	28-39	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	41-47
3030298-5	1987	The ability of mucin to retard the diffusion of hydrogen ion increased by 7% following removal of fucose or N-acetylgalactosamine, a 28% increase was obtained following removal of sialic acid, while the permeability to hydrogen ion of the extensively deglycosylated glycoprotein decreased by 42%.	N-Acetylneuraminic Acid	180-191	mucin	Canis lupus familiaris	15-20
3493700-8	1987	AAT isolated from the plasma of GalNH2-treated rats contains 2-3 fewer moles of sialic acid, 3 fewer moles of neutral sugar, and 2 fewer moles of amino sugar per mole of antiprotease than AAT isolated from controls.	N-Acetylneuraminic Acid	80-91	serpin family A member 1	Rattus norvegicus	0-3
3493700-9	1987	AP2 from GalNH2-treated rats contains 1 fewer mole each of sialic acid, neutral sugar, and amino sugar per mole of antiprotease than AP2 from controls.	N-Acetylneuraminic Acid	59-70	fatty acid binding protein 4	Rattus norvegicus	0-3
3543123-7	1987	Introduction of a human beta 2-microglobulin gene into L cells transfected with the HLA-B27 gene rescued the expression of HLA-B27 at the cell surface, as evidenced by reactivity with W6/32, surface staining, and the presence of sialic acid on the heavy chain.	N-Acetylneuraminic Acid	229-240	beta-2-microglobulin	Homo sapiens	24-44
3543123-7	1987	Introduction of a human beta 2-microglobulin gene into L cells transfected with the HLA-B27 gene rescued the expression of HLA-B27 at the cell surface, as evidenced by reactivity with W6/32, surface staining, and the presence of sialic acid on the heavy chain.	N-Acetylneuraminic Acid	229-240	major histocompatibility complex, class I, B	Homo sapiens	84-91
3543123-7	1987	Introduction of a human beta 2-microglobulin gene into L cells transfected with the HLA-B27 gene rescued the expression of HLA-B27 at the cell surface, as evidenced by reactivity with W6/32, surface staining, and the presence of sialic acid on the heavy chain.	N-Acetylneuraminic Acid	229-240	major histocompatibility complex, class I, B	Homo sapiens	123-130
2437241-2	1987	Owing to its low content of sialic acid, beta 2-transferrin migrates more slowly than the main transferrin component (beta 1-transferrin) in electrophoresis.	N-Acetylneuraminic Acid	28-39	transferrin	Homo sapiens	48-59
3297033-8	1987	The release of sialic acid by graded neuraminidase digestion and the increase in Con A-agglutinability show a correlation coefficient of 0.88.	N-Acetylneuraminic Acid	15-26	neuraminidase 1	Homo sapiens	37-50
3566706-2	1987	All forms exhibited a rather broad linkage specificity and were capable of hydrolyzing sialic acid glycosidically linked alpha 2-3, alpha 2-6 and alpha 2-8, although differential rates of hydrolysis of the substrates were found for each form.	N-Acetylneuraminic Acid	87-98	immunoglobulin binding protein 1	Homo sapiens	146-155
2951469-7	1987	ApoB isolated by this procedure was essentially identical to apoB from autologous LDL with respect to molecular weight, secondary structure, amino acid composition, and sialic acid content.	N-Acetylneuraminic Acid	169-180	apolipoprotein B	Homo sapiens	0-4
3491643-8	1987	Neuraminidase treatment reduced these electrophoretic differences, indicating that these molecules differ in their sialic acid content.	N-Acetylneuraminic Acid	115-126	neuraminidase 1	Homo sapiens	0-13
3497774-6	1987	Removal of sialic acid with neuraminidase increased the percentage of cells showing CMF.	N-Acetylneuraminic Acid	11-22	neuraminidase 1	Homo sapiens	28-41
3557459-5	1987	Stepwise removal of N-acetyl-neuraminic acid (NANA) with neuraminidase revealed that the most cathodal variant TF DShinnanyo found in a Japanese family was characterized by having only two NANA residues.	N-Acetylneuraminic Acid	20-44	transferrin	Homo sapiens	111-113
3440449-3	1987	Lipid-bound sialic acid was increased up to 8-fold in visceral organs due to elevated amounts of gangliosides GM3, GD3 and probably GM4 and LM1, whereas the brain showed no deviation from controls.	N-Acetylneuraminic Acid	12-23	GRDX	Homo sapiens	115-118
3472018-6	1987	The KG-1 myeloblastoid and U937 myelomonocytic lines could be induced to express the antigen, when exposed to neuraminidase which removes terminal sialic acid from carbohydrate residues.	N-Acetylneuraminic Acid	147-158	neuraminidase 1	Homo sapiens	110-123
3782473-4	1986	Of the known components of the oligosaccharide chain, only sialic acid prevented enhancement by the cochemotaxin of the chemotactic activity exhibited by native C5a des Arg.	N-Acetylneuraminic Acid	59-70	complement C5a receptor 1	Homo sapiens	161-164
3779103-2	1986	Neuraminidase-inaccessible, ie residual cell-associated sialic acid after neuraminidase treatment, was four- to twelvefold lower in the three differentiation-inducer-resistant sublines than in the parent line.	N-Acetylneuraminic Acid	56-67	neuraminidase 1	Homo sapiens	0-13
3821718-5	1987	Their immunoreactivity is dependent upon sialic acid because prior digestion with neuraminidase abolished their immunoreactivity.	N-Acetylneuraminic Acid	41-52	neuraminidase 1	Homo sapiens	82-95
3023487-2	1986	Enzymatic digestions demonstrated that the released IL 2R, like the cell surface IL 2R, is a complex glycoprotein, modified by the addition of both N- and O-linked carbohydrates and sialic acid residues.	N-Acetylneuraminic Acid	182-193	interleukin 2 receptor subunit alpha	Homo sapiens	52-57
3023487-2	1986	Enzymatic digestions demonstrated that the released IL 2R, like the cell surface IL 2R, is a complex glycoprotein, modified by the addition of both N- and O-linked carbohydrates and sialic acid residues.	N-Acetylneuraminic Acid	182-193	interleukin 2 receptor subunit alpha	Homo sapiens	81-86
3536966-4	1986	This antibody recognizes alpha 2-8-linked N-acetylneuraminic acid units (NeuAc alpha 2-8).	N-Acetylneuraminic Acid	42-65	immunoglobulin binding protein 1	Homo sapiens	25-34
3536966-4	1986	This antibody recognizes alpha 2-8-linked N-acetylneuraminic acid units (NeuAc alpha 2-8).	N-Acetylneuraminic Acid	42-65	immunoglobulin binding protein 1	Homo sapiens	79-88
3536966-4	1986	This antibody recognizes alpha 2-8-linked N-acetylneuraminic acid units (NeuAc alpha 2-8).	N-Acetylneuraminic Acid	73-78	immunoglobulin binding protein 1	Homo sapiens	25-34
3536966-4	1986	This antibody recognizes alpha 2-8-linked N-acetylneuraminic acid units (NeuAc alpha 2-8).	N-Acetylneuraminic Acid	73-78	immunoglobulin binding protein 1	Homo sapiens	79-88
3794983-2	1986	The TCA is exposed when bacterially derived neuraminidase acts on the surface of the red cells, cleaving off the N-acetylneuraminic acid, which hides the antigen.	N-Acetylneuraminic Acid	113-136	neuraminidase 1	Homo sapiens	44-57
3782473-5	1986	Sialic acid also prevented the formation of C5a des Arg-cochemotaxin complexes, detected by acid polyacrylamide gel electrophoresis, molecular sieve chromatography on polyacrylamide gels, and sucrose density gradient ultracentrifugation.	N-Acetylneuraminic Acid	0-11	complement C5a receptor 1	Homo sapiens	44-47
3801415-5	1986	SGP-2 was shown to be 23.7% carbohydrate and consisted of 1% fucose, 3.5% mannose, 4.1% galactose, 7.1% N-acetylglucosamine, and 8.0% N-acetylneuraminic acid.	N-Acetylneuraminic Acid	134-157	clusterin	Homo sapiens	0-5
3780977-0	1986	Calmodulin may decrease cell surface sialic acid and be involved in the expression of fibronectin during liver regeneration.	N-Acetylneuraminic Acid	37-48	calmodulin 1	Homo sapiens	0-10
3542320-2	1986	Neuraminidase may react with immunoglobulins in the circulation and with sialic acid-rich sites in the endothelial and epithelial glomerular capillary, therefore, extrinsic or intrinsic sialic acid-depleted substrate may be localized in the glomeruli.	N-Acetylneuraminic Acid	73-84	neuraminidase 1	Homo sapiens	0-13
3103611-5	1986	A carbohydrate-free fraction as well as two NeuAc-containing fractions were compared in their substrate behaviour towards the action of the milk-clotting enzyme chymosin at pH 6.6 and 30 degrees C. To this end the trichloroacetic acid-soluble reaction products were analysed by high-performance gel-permeation chromatography.	N-Acetylneuraminic Acid	44-49	chymosin	Bos taurus	161-169
3542320-2	1986	Neuraminidase may react with immunoglobulins in the circulation and with sialic acid-rich sites in the endothelial and epithelial glomerular capillary, therefore, extrinsic or intrinsic sialic acid-depleted substrate may be localized in the glomeruli.	N-Acetylneuraminic Acid	186-197	neuraminidase 1	Homo sapiens	0-13
3818580-2	1986	Compositional analyses of the purified glycoproteins showed that GPIIb and GPIIIa contain 15% and 18% carbohydrate by weight, respectively, which consists of galactose, mannose, glucosamine, fucose, and sialic acid.	N-Acetylneuraminic Acid	203-214	integrin subunit alpha 2b	Homo sapiens	65-70
3533998-1	1986	Glomerular visceral epithelial cells are endowed with a sialic acid-rich surface coat (the "glomerular epithelial polyanion"), which in rat tissue contains the sialoprotein podocalyxin.	N-Acetylneuraminic Acid	56-67	cysteine-rich secretory protein 3	Rattus norvegicus	160-172
3533998-1	1986	Glomerular visceral epithelial cells are endowed with a sialic acid-rich surface coat (the "glomerular epithelial polyanion"), which in rat tissue contains the sialoprotein podocalyxin.	N-Acetylneuraminic Acid	56-67	podocalyxin-like	Rattus norvegicus	173-184
3818580-2	1986	Compositional analyses of the purified glycoproteins showed that GPIIb and GPIIIa contain 15% and 18% carbohydrate by weight, respectively, which consists of galactose, mannose, glucosamine, fucose, and sialic acid.	N-Acetylneuraminic Acid	203-214	integrin subunit beta 3	Homo sapiens	75-81
3533998-2	1986	We have identified a major membrane sialoprotein in human glomeruli that is similar to rat podocalyxin in its sialic acid-dependent binding of wheat germ agglutinin and in its localization on the surface of glomerular epithelial and endothelial cells, as shown by immunoelectron microscopy, using the monoclonal antibody PHM5.	N-Acetylneuraminic Acid	110-121	cysteine-rich secretory protein 3	Rattus norvegicus	36-48
3533998-2	1986	We have identified a major membrane sialoprotein in human glomeruli that is similar to rat podocalyxin in its sialic acid-dependent binding of wheat germ agglutinin and in its localization on the surface of glomerular epithelial and endothelial cells, as shown by immunoelectron microscopy, using the monoclonal antibody PHM5.	N-Acetylneuraminic Acid	110-121	podocalyxin-like	Rattus norvegicus	91-102
3818560-3	1986	Compositional analysis showed that GPIV contains large amounts of acidic and hydroxy amino acids, but only very small amounts of cystine and methionine, and 28.1% (w/w) carbohydrate consisting of galactose, glucosamine, and sialic acid as the principal sugars with smaller amounts of fucose, mannose, and galactosamine.	N-Acetylneuraminic Acid	224-235	CD36 molecule	Homo sapiens	35-39
3794447-11	1986	of 75,000 to 100,000, which is present in crude hCG but different from genuine hCG, has potent immunosuppressive effects and that sialic acid residues in the substance(s) are related to the manifestation of these effects.	N-Acetylneuraminic Acid	130-141	chorionic gonadotropin subunit beta 5	Homo sapiens	48-51
3771533-9	1986	Thus, critical neuraminidase-sensitive components of the complex (sialic acid residues) are not exposed on the surface of the platelet membrane of resting platelets, but do become accessible following platelet stimulation with ADP or membrane solubilization with Triton X-100.	N-Acetylneuraminic Acid	66-77	neuraminidase 1	Homo sapiens	15-28
3020031-8	1986	These findings suggest that apoE is secreted in the form of three major isoproteins generated by intracellular modification of this protein with one or more O-linked oligosaccharide chains containing sialic acid.	N-Acetylneuraminic Acid	200-211	apolipoprotein E	Homo sapiens	28-32
2430922-6	1986	These results suggest that distinct structural changes in the carbohydrate moiety may occur during the releasing process of CEA from cells, and that, in some cases, some epitopes may be masked by attachment of sialic acid residues.	N-Acetylneuraminic Acid	210-221	CEA cell adhesion molecule 3	Homo sapiens	124-127
3576054-2	1986	Alterations of thrombin time were found in newborns and in 14 cirrhotic patients; glucide fraction levels were measured in these subjects and an increase in sialic acid content was observed.	N-Acetylneuraminic Acid	157-168	coagulation factor II, thrombin	Homo sapiens	15-23
3576054-4	1986	We observed a thrombin time normalization, which was initially prolonged upon the removal of the sialic acid.	N-Acetylneuraminic Acid	97-108	coagulation factor II, thrombin	Homo sapiens	14-22
3017434-3	1986	The sialic acid moieties on the oligosaccharide groups on the beta subunit of (Na+ + K+)-ATPase were labeled with NaB3H4 after oxidation by sodium periodate, or the penultimate galactose residues on the oligosaccharides were similarly labeled after removal of sialic acid with neuraminidase and oxidation by galactose oxidase.	N-Acetylneuraminic Acid	4-15	neuraminidase 1	Homo sapiens	277-290
2426082-10	1986	TSH secreted in the presence of TRH had a lower sulfate to mannose ratio [28 +/- (+/- SE) 4% of control; P less than 0.05] and a lower sialic acid to mannose ratio (63 +/- 8% of control; P less than 0.05).	N-Acetylneuraminic Acid	135-146	thyrotropin releasing hormone	Mus musculus	32-35
2427577-4	1986	Treatment with endo-alpha-N-acetylgalactosaminidase to remove O-linked oligosaccharides resulted in a 48,000 Mr molecule (67% of the Mr shift being due to sialic acid), which decreased to 45,000 Mr after sequential endoglycosidase F treatment.	N-Acetylneuraminic Acid	155-166	alpha-N-acetylgalactosaminidase	Homo sapiens	20-51
3025822-9	1986	Our studies indicate that mammalian lung VIP receptors are glycoproteins containing terminal sialic acid residues.	N-Acetylneuraminic Acid	93-104	vasoactive intestinal peptide	Homo sapiens	41-44
3768898-3	1986	Substitution of the N-acetyllactosamine sequences by sialic acid residues, either at O-3 or O-6 of galactose completely abolishes the affinity of the lectins for the saccharides.	N-Acetylneuraminic Acid	53-64	immunoglobulin kappa variable 2D-38 (pseudogene)	Homo sapiens	85-95
2426082-4	1986	Each of the three secreted subunits (TSH alpha, TSH beta, and free alpha) incorporated both sulfate and sialic acid.	N-Acetylneuraminic Acid	104-115	glycoprotein hormones, alpha subunit	Mus musculus	37-46
3788408-2	1986	The pure alpha 1 acid glycoprotein (AGP) preparation from streptozotocin diabetic rat sera showed diminished sialic acid content and lower ratios of galactose to mannose and galactose to fucose.	N-Acetylneuraminic Acid	109-120	orosomucoid 1	Rattus norvegicus	9-34
2426082-4	1986	Each of the three secreted subunits (TSH alpha, TSH beta, and free alpha) incorporated both sulfate and sialic acid.	N-Acetylneuraminic Acid	104-115	thyroid stimulating hormone, beta subunit	Mus musculus	48-56
2941420-9	1986	Apo(a) contained 28.1% carbohydrate by weight represented by mannose, galactose, galactosamine, glucosamine, and sialic acid in an approximate molar ratio of 3:7:5:4:7, respectively.	N-Acetylneuraminic Acid	113-124	lipoprotein(a)	Homo sapiens	0-6
3020153-3	1986	Treatment with neuraminidase (EC 3.2.1.18) removes sialic acid from the molecule.	N-Acetylneuraminic Acid	51-62	neuraminidase 1	Homo sapiens	15-28
3800894-7	1986	The gel patterns showing higher-molecular-mass components are obtained when terminal sialic acid addition is prevented by the incubation of lung tissue with monensin or when terminal sialic acids are digested from the fully processed protein with neuraminidase.	N-Acetylneuraminic Acid	85-96	neuraminidase 1	Homo sapiens	247-260
3740419-4	1986	It was used to identify reaction products in two enzymatic reactions: the conversion of UDP-N-acetylglucosamine to N-acetylmannosamine and UDP by UDP-N-acetylglucosamine 2-epimerase and the conversion of N-acetylneuraminic acid to N-acetylmannosamine and pyruvate by N-acetylneuraminate pyruvate-lyase.	N-Acetylneuraminic Acid	204-227	N-acetylneuraminate pyruvate lyase	Homo sapiens	267-301
3788408-2	1986	The pure alpha 1 acid glycoprotein (AGP) preparation from streptozotocin diabetic rat sera showed diminished sialic acid content and lower ratios of galactose to mannose and galactose to fucose.	N-Acetylneuraminic Acid	109-120	orosomucoid 1	Rattus norvegicus	36-39
2875027-4	1986	On the other hand, a decrease of Thy-1 or an increase of H-2K may be ascribed to the decrease of Nase-resistant sialic acid on the cell surface, determined by analyses with FITC-LPA, sialic acid-specific lectin, and by metabolic labeling of surface sialic acid.	N-Acetylneuraminic Acid	112-123	thymus cell antigen 1, theta	Mus musculus	33-38
3753507-3	1986	Since it possessed a high sialic acid content and an alpha-lactalbumin-like activity, it was proposed to be a sialylated form of epididymal alpha-lactalbumin-like protein.	N-Acetylneuraminic Acid	26-37	lactalbumin, alpha	Rattus norvegicus	140-157
2875027-0	1986	Indomethacin-induced sialic acid-mediated changes in surface markers from "cortical type" to "medullary type" in murine thymoma line EL-4.	N-Acetylneuraminic Acid	21-32	epilepsy 4	Mus musculus	133-137
2875027-4	1986	On the other hand, a decrease of Thy-1 or an increase of H-2K may be ascribed to the decrease of Nase-resistant sialic acid on the cell surface, determined by analyses with FITC-LPA, sialic acid-specific lectin, and by metabolic labeling of surface sialic acid.	N-Acetylneuraminic Acid	112-123	histocompatibility 2, K1, K region	Mus musculus	57-61
2875027-4	1986	On the other hand, a decrease of Thy-1 or an increase of H-2K may be ascribed to the decrease of Nase-resistant sialic acid on the cell surface, determined by analyses with FITC-LPA, sialic acid-specific lectin, and by metabolic labeling of surface sialic acid.	N-Acetylneuraminic Acid	183-194	thymus cell antigen 1, theta	Mus musculus	33-38
2875027-4	1986	On the other hand, a decrease of Thy-1 or an increase of H-2K may be ascribed to the decrease of Nase-resistant sialic acid on the cell surface, determined by analyses with FITC-LPA, sialic acid-specific lectin, and by metabolic labeling of surface sialic acid.	N-Acetylneuraminic Acid	183-194	histocompatibility 2, K1, K region	Mus musculus	57-61
2875027-4	1986	On the other hand, a decrease of Thy-1 or an increase of H-2K may be ascribed to the decrease of Nase-resistant sialic acid on the cell surface, determined by analyses with FITC-LPA, sialic acid-specific lectin, and by metabolic labeling of surface sialic acid.	N-Acetylneuraminic Acid	183-194	thymus cell antigen 1, theta	Mus musculus	33-38
2875027-4	1986	On the other hand, a decrease of Thy-1 or an increase of H-2K may be ascribed to the decrease of Nase-resistant sialic acid on the cell surface, determined by analyses with FITC-LPA, sialic acid-specific lectin, and by metabolic labeling of surface sialic acid.	N-Acetylneuraminic Acid	183-194	histocompatibility 2, K1, K region	Mus musculus	57-61
3086747-3	1986	There is evidence that part of this recycling process involves the distal region of the Golgi complex, where terminal glycosylation occurs: when the plasma membrane transferrin receptor is desialylated by neuraminidase treatment, it acquires new sialic acid molecules after endocytosis and before cell-surface re-expression.	N-Acetylneuraminic Acid	246-257	neuraminidase 1	Homo sapiens	205-218
3522754-7	1986	After this period N-acetyllactosamine could only be demonstrated on basal cells after treatment with neuraminidase, indicating a masking of N-acetyllactosamine by sialic acid.	N-Acetylneuraminic Acid	163-174	neuraminidase 1	Homo sapiens	101-114
3718996-3	1986	The purified hog lecithin-cholesterol acyltransferase had an apparent molecular weight of 66 000 on SDS-polyacrylamide gel electrophoresis and HPLC and was found to contain about 21.4% (w/w) carbohydrate-hexose, 11.3%; hexosamine, 1.9%; sialic acid, 8.2%.	N-Acetylneuraminic Acid	237-248	lecithin-cholesterol acyltransferase	Homo sapiens	17-53
3017350-2	1986	A radioactively labelled moiety resulted, which behaved as a derivative of N-acetyl neuraminic acid during mild acid hydrolysis, neuraminidase treatment, ion exchange chromatography and paper chromatography.	N-Acetylneuraminic Acid	75-99	neuraminidase 1	Homo sapiens	129-142
3529502-5	1986	Among monosaccharides, 2-deoxy-D-ribose, D-galactosamine, L-fucose, N-acetylneuraminic acid and D-ribose decreased insulin release and had no effect on insulin release by D-glucose.	N-Acetylneuraminic Acid	68-91	insulin	Homo sapiens	115-122
3793775-9	1986	When additional neuraminidase treatment was used to remove terminal sialic acid residues, the total labelling intensity was increased two- to fivefold and additional 36,000 and 20,000 Mr glycoproteins were revealed.	N-Acetylneuraminic Acid	68-79	neuraminidase 1	Homo sapiens	16-29
3518835-6	1986	Platelet LFA-1, as demonstrated by surface iodination with lactoperoxidase and by labeling sialic acid residues with sodium borohydride, was not a major component of the platelet membrane.	N-Acetylneuraminic Acid	91-102	integrin alpha L	Mus musculus	9-14
3717159-9	1986	Differences between the allele products remained after removal of sialic acid from the glycoprotein with neuraminidase.	N-Acetylneuraminic Acid	66-77	neuraminidase 1	Homo sapiens	105-118
3718508-1	1986	Purified rat liver lysosomes were incubated in 0.2 M sialic acid resulting in an increase in lysosomal free sialic acid of 3.8 +/- 1.5 nmol/unit beta hexosaminidase.	N-Acetylneuraminic Acid	53-64	O-GlcNAcase	Rattus norvegicus	145-164
3718508-1	1986	Purified rat liver lysosomes were incubated in 0.2 M sialic acid resulting in an increase in lysosomal free sialic acid of 3.8 +/- 1.5 nmol/unit beta hexosaminidase.	N-Acetylneuraminic Acid	108-119	O-GlcNAcase	Rattus norvegicus	145-164
3718965-2	1986	For SAT-1 and SAT-3, respectively, the apparent Km values with variable CMP-NeuAc concentrations were 0.19 and 0.015 mM and with variable LacCer were 0.075 and 0.17 mM.	N-Acetylneuraminic Acid	76-81	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	14-19
3519974-1	1986	The level of sialic acid removable by neuraminidase from macrophages of bacteriologically-positive lepromatous leprosy (B(+)LL) patient is extremely low, compared to macrophages from tuberculoid leprosy patients or normal individuals.	N-Acetylneuraminic Acid	13-24	neuraminidase 1	Homo sapiens	38-51
3958047-7	1986	Desialation was confirmed by incubation of endothelium with double-labeled CP (3H label on sialic acid and 125I on the protein part).	N-Acetylneuraminic Acid	91-102	ceruloplasmin	Homo sapiens	75-77
3005298-6	1986	The purified brain insulin receptor was found to be identical with the placental insulin receptor in the amount of neuraminidase-sensitive sialic acid and reaction with three monoclonal antibodies to the beta subunit of the placental receptor.	N-Acetylneuraminic Acid	139-150	insulin receptor	Homo sapiens	19-35
3005298-6	1986	The purified brain insulin receptor was found to be identical with the placental insulin receptor in the amount of neuraminidase-sensitive sialic acid and reaction with three monoclonal antibodies to the beta subunit of the placental receptor.	N-Acetylneuraminic Acid	139-150	insulin receptor	Homo sapiens	81-97
3005298-6	1986	The purified brain insulin receptor was found to be identical with the placental insulin receptor in the amount of neuraminidase-sensitive sialic acid and reaction with three monoclonal antibodies to the beta subunit of the placental receptor.	N-Acetylneuraminic Acid	139-150	neuraminidase 1	Homo sapiens	115-128
3005298-8	1986	These results indicate that the brain insulin receptor differs from the receptor in other tissues and suggests that this difference is not simply due to the amount of sialic acid on the receptor.	N-Acetylneuraminic Acid	167-178	insulin receptor	Homo sapiens	38-54
3005335-9	1986	In this regard, controlled periodate oxidation of terminal, unsubstituted sialic acid residues on the cell surface not only specifically destroys the antigenic epitopes on GD2 and GD3 recognized by specific Mabs but also inhibits melanoma cell and neuroblastoma cell attachment.	N-Acetylneuraminic Acid	74-85	GRDX	Homo sapiens	180-183
3516709-2	1986	The NK-9 antigens had apparent molecular masses of 190, 200 and 220 kDa and were sensitive to neuraminidase and sodium metaperiodate treatments, which destroy the sialic acid residues of the cell surface glycoproteins.	N-Acetylneuraminic Acid	163-174	neuraminidase 1	Homo sapiens	94-107
3523174-3	1986	Similarly removal of sialic acid from the carbohydrate coat of erythropoietin both increases clearance by the liver and renders it susceptible to cleavage into inactive fragments by proteolytic attack.	N-Acetylneuraminic Acid	21-32	erythropoietin	Homo sapiens	63-77
3514617-10	1986	The structures of the O-linked units were inferred experimentally to be NeuAc(alpha 2,3)Gal-(beta 1,3)GalNAc and NeuAc(alpha 2,3)Gal(beta 1,3) [NeuAc(alpha 2,6)]GalNAc, present in a ratio similar to that found in controls; and the Asn-linked unit also appeared to be as in the control.	N-Acetylneuraminic Acid	72-77	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	93-141
2424829-6	1986	The pI value of IL-2 prepared from ISO-treated PBMC shifted to 8.2 after treatment with neuraminidase, demonstrating that the IL-2 molecules isolated from ISO-treated PBMC possessed sialic acid.	N-Acetylneuraminic Acid	182-193	interleukin 2	Homo sapiens	16-20
2424829-6	1986	The pI value of IL-2 prepared from ISO-treated PBMC shifted to 8.2 after treatment with neuraminidase, demonstrating that the IL-2 molecules isolated from ISO-treated PBMC possessed sialic acid.	N-Acetylneuraminic Acid	182-193	neuraminidase 1	Homo sapiens	88-101
2424829-6	1986	The pI value of IL-2 prepared from ISO-treated PBMC shifted to 8.2 after treatment with neuraminidase, demonstrating that the IL-2 molecules isolated from ISO-treated PBMC possessed sialic acid.	N-Acetylneuraminic Acid	182-193	interleukin 2	Homo sapiens	126-130
3080028-3	1986	Incorporation of N-[3H]acetylmannosamine, a sialic acid precursor, into apolipoprotein E was measurable after 120 min, whereas no [3H]mannose incorporation could be observed.	N-Acetylneuraminic Acid	44-55	apolipoprotein E	Homo sapiens	72-88
3942785-8	1986	Treatment of serotonectin with neuraminidase resulted in a quantitative release of sialic acid without loss of antigenicity or binding capacity for [3H]serotonin.	N-Acetylneuraminic Acid	83-94	neuraminidase 1	Homo sapiens	31-44
3512542-0	1986	The role of cell surface sialic acid in insulin receptor function and insulin action.	N-Acetylneuraminic Acid	25-36	insulin receptor	Homo sapiens	40-56
3512542-0	1986	The role of cell surface sialic acid in insulin receptor function and insulin action.	N-Acetylneuraminic Acid	25-36	insulin	Homo sapiens	40-47
3512542-1	1986	Removal of cell surface sialic acid from adipocytes with neuraminidase inhibits insulin action.	N-Acetylneuraminic Acid	24-35	neuraminidase 1	Homo sapiens	57-70
3512542-1	1986	Removal of cell surface sialic acid from adipocytes with neuraminidase inhibits insulin action.	N-Acetylneuraminic Acid	24-35	insulin	Homo sapiens	80-87
2418097-4	1986	The sialic acid-containing bovine kappa-casein stained blue-green.	N-Acetylneuraminic Acid	4-15	casein kappa	Bos taurus	34-46
3511719-2	1986	However, the authors found that after neuraminidase treatment for removal of sialic acid, the L&H cells in more than half of the cases studied could be stained by anti-Leu M1.	N-Acetylneuraminic Acid	77-88	neuraminidase 1	Homo sapiens	38-51
3456572-0	1986	A sialic acid-specific O-acetylesterase in human erythrocytes: possible identity with esterase D, the genetic marker of retinoblastomas and Wilson disease.	N-Acetylneuraminic Acid	2-13	esterase D	Homo sapiens	86-96
3456572-6	1986	We next present evidence that suggests that esterase D is identical to this sialic acid-specific O-acetylesterase.	N-Acetylneuraminic Acid	76-87	esterase D	Homo sapiens	44-54
3491010-1	1986	Human urinary neuraminidase, an enzyme that releases sialic acid from hematopoietic factors found in urinary preparations, was partially characterized, and a method was developed to derive these hematopoietic factors free of enzyme activity.	N-Acetylneuraminic Acid	53-64	neuraminidase 1	Homo sapiens	14-27
3749868-0	1986	1H NMR investigation of the binding of methyl-beta-D-galactoses with sialic acid residues on hepatic binding protein--the effect of divalent calcium ions.	N-Acetylneuraminic Acid	69-80	heme binding protein 1	Homo sapiens	93-116
3749868-1	1986	The present study is a proton NMR investigation of the influence of Ca2+ on the interaction between the intact sialic acid residues on HBP (Hepatic Binding Protein) and methyl-beta-D-galactoses.	N-Acetylneuraminic Acid	111-122	heme binding protein 1	Homo sapiens	135-138
3749868-1	1986	The present study is a proton NMR investigation of the influence of Ca2+ on the interaction between the intact sialic acid residues on HBP (Hepatic Binding Protein) and methyl-beta-D-galactoses.	N-Acetylneuraminic Acid	111-122	heme binding protein 1	Homo sapiens	140-163
3749868-3	1986	The analysis of the experimental results indicates that Ca2+ participates in the binding of sialic acid residues on HBP with methyl-beta-D-galactoses and this enables the galactose molecules to be in stable bound state.	N-Acetylneuraminic Acid	92-103	heme binding protein 1	Homo sapiens	116-119
3093007-5	1986	Prior to coupling, the subunits of hCG were crosslinked with 1-ethyl-3-(dimethylamino propyl) carbodiimide and the sialic acid residues were subjected to periodate oxidation to yield aldehyde groups which could react with the hydrazides of the gel.	N-Acetylneuraminic Acid	115-126	hypertrichosis 2 (generalised, congenital)	Homo sapiens	35-38
3743024-1	1986	Sialyltransferase activity of bovine serum with the acceptor asialofetuin exhibits a pH optimum at 6.0-6.5, no divalent cation dependence, and a Km for CMP-sialic acid of 0.05 mM.	N-Acetylneuraminic Acid	156-167	alpha 2-HS glycoprotein	Bos taurus	61-73
3014270-3	1986	ApoE is further modified intracellularly with carbohydrate chains containing sialic acid and is secreted in the modified form designated apoEs.	N-Acetylneuraminic Acid	77-88	apolipoprotein E	Homo sapiens	0-4
3940285-5	1986	Treatment of receptors with neuraminidase to remove N-acetylneuraminic acid residues reduced binding to wheat germ agglutinin-agarose by 40%; further treatment with endoglycosidases D and H, to remove all N-linked carbohydrate, decreased binding by a total of 67%.	N-Acetylneuraminic Acid	52-75	neuraminidase 1	Bos taurus	28-41
2870429-2	1986	Comparison of immature with mature T-cells has shown that the oligosaccharides of Thy-1 are characterized by an increase in the number of sialic acid residues responsible for the acidic pI of peripheral T-cell Thy-1, and a decrease in those oligosaccharides responsible for Mr heterogeneity of thymocyte Thy-1.	N-Acetylneuraminic Acid	138-149	thymus cell antigen 1, theta	Mus musculus	82-87
2870429-2	1986	Comparison of immature with mature T-cells has shown that the oligosaccharides of Thy-1 are characterized by an increase in the number of sialic acid residues responsible for the acidic pI of peripheral T-cell Thy-1, and a decrease in those oligosaccharides responsible for Mr heterogeneity of thymocyte Thy-1.	N-Acetylneuraminic Acid	138-149	thymus cell antigen 1, theta	Mus musculus	210-215
2870429-2	1986	Comparison of immature with mature T-cells has shown that the oligosaccharides of Thy-1 are characterized by an increase in the number of sialic acid residues responsible for the acidic pI of peripheral T-cell Thy-1, and a decrease in those oligosaccharides responsible for Mr heterogeneity of thymocyte Thy-1.	N-Acetylneuraminic Acid	138-149	thymus cell antigen 1, theta	Mus musculus	210-215
3014270-8	1986	Other known apolipoprotein modifications include the modification of apoB, apoC-III, and apoD with carbohydrate chains that contain sialic acid and the proteolytic cleavage of the proapoA-II segment.	N-Acetylneuraminic Acid	132-143	apolipoprotein E	Homo sapiens	12-26
3014270-8	1986	Other known apolipoprotein modifications include the modification of apoB, apoC-III, and apoD with carbohydrate chains that contain sialic acid and the proteolytic cleavage of the proapoA-II segment.	N-Acetylneuraminic Acid	132-143	apolipoprotein B	Homo sapiens	69-73
3014270-8	1986	Other known apolipoprotein modifications include the modification of apoB, apoC-III, and apoD with carbohydrate chains that contain sialic acid and the proteolytic cleavage of the proapoA-II segment.	N-Acetylneuraminic Acid	132-143	apolipoprotein D	Homo sapiens	89-93
3716020-0	1986	Determination of sialic acid residues in transferrin by oxidative-reductive immunoassay.	N-Acetylneuraminic Acid	17-28	transferrin	Homo sapiens	41-52
3603925-1	1986	Transferrin was double-labeled, with its sialic acid residues being labeled with 3H and its protein part with either 125I or 59Fe.	N-Acetylneuraminic Acid	41-52	transferrin	Homo sapiens	0-11
3002369-5	1985	Neuraminidase treatment of the alpha-subunits from each cell type indicated more sialic acid residues were present on the monocyte than the red cell alpha-subunit.	N-Acetylneuraminic Acid	81-92	neuraminidase 1	Homo sapiens	0-13
2415516-8	1985	Digestion of the alpha 1, alpha 2, and beta subunits with neuraminidase and with endoglycosidase F revealed that each subunit contains substantial sialic acid and N-linked carbohydrate.	N-Acetylneuraminic Acid	147-158	adrenoceptor alpha 1D	Homo sapiens	17-33
3866237-3	1985	In NaDodSO4/PAGE, sialic acid residues of normal glomeruli were mainly confined to a 140-kDa protein previously identified as podocalyxin.	N-Acetylneuraminic Acid	18-29	podocalyxin-like	Rattus norvegicus	126-137
4063969-7	1985	Pretreatment of the tissue with neuraminidase abolished YPan1"s reactivity, which indicated that sialic acid may be involved in the antigenic activity of the molecule(s) recognized by YPan1.	N-Acetylneuraminic Acid	97-108	neuraminidase 1	Homo sapiens	32-45
4091823-7	1985	carry the same pentasaccharide GalNAc(beta 1-4)[NeuAc(alpha 2-3)]Gal(beta 1-3)[NeuAc(alpha 2-6)]GalNAc -ol(Cad determinant) but in different amounts.	N-Acetylneuraminic Acid	48-53	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	38-46
4091823-7	1985	carry the same pentasaccharide GalNAc(beta 1-4)[NeuAc(alpha 2-3)]Gal(beta 1-3)[NeuAc(alpha 2-6)]GalNAc -ol(Cad determinant) but in different amounts.	N-Acetylneuraminic Acid	48-53	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	69-77
4091823-7	1985	carry the same pentasaccharide GalNAc(beta 1-4)[NeuAc(alpha 2-3)]Gal(beta 1-3)[NeuAc(alpha 2-6)]GalNAc -ol(Cad determinant) but in different amounts.	N-Acetylneuraminic Acid	79-84	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	38-46
4091823-7	1985	carry the same pentasaccharide GalNAc(beta 1-4)[NeuAc(alpha 2-3)]Gal(beta 1-3)[NeuAc(alpha 2-6)]GalNAc -ol(Cad determinant) but in different amounts.	N-Acetylneuraminic Acid	79-84	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	69-77
4073011-0	1985	Transferrin sialic acid contents of patients with hereditary hemochromatosis.	N-Acetylneuraminic Acid	12-23	transferrin	Homo sapiens	0-11
3003212-3	1985	PNA is highly specific for the terminal carbohydrate linkage Gal beta-(1----3)-Gal NAc which is only exposed to hCG when the O-serine linked oligosaccharide of its unique beta-CTP region is deficient in sialic acid.	N-Acetylneuraminic Acid	203-214	synuclein alpha	Homo sapiens	83-86
3003212-3	1985	PNA is highly specific for the terminal carbohydrate linkage Gal beta-(1----3)-Gal NAc which is only exposed to hCG when the O-serine linked oligosaccharide of its unique beta-CTP region is deficient in sialic acid.	N-Acetylneuraminic Acid	203-214	chorionic gonadotropin subunit beta 5	Homo sapiens	112-115
4052781-6	1985	Degradative experiments using neuraminidase to remove sialic acid residues and endoglycosidase F to remove all N-linked oligosaccharides indicate that the polymorphism of the NILE-related glycoproteins may be due to differences both at the polypeptide level and at the level of glycosylation.	N-Acetylneuraminic Acid	54-65	L1 cell adhesion molecule	Rattus norvegicus	175-179
3841289-4	1985	The ability to fuse is partially restored after treating the glycophorin-containing vesicles with neuraminidase, which removes the negatively charged sialic acid residues of glycophorin.	N-Acetylneuraminic Acid	150-161	neuraminidase 1	Bos taurus	98-111
3878227-0	1985	Content of red blood-cell sialic acid in BW 35 blood donors.	N-Acetylneuraminic Acid	26-37	BW35	Homo sapiens	41-46
4042983-7	1985	Radioactive labeling of sialic acid by limited periodate oxidation and NaB[3H]4 reduction resulted in a higher specific activity for free alpha than for hCG alpha, suggesting that free alpha contains more sialic acid per immunoreactive molecule than does alpha dissociated from hCG.	N-Acetylneuraminic Acid	24-35	chromogranin A	Homo sapiens	153-162
3866610-0	1985	Ia-associated invariant chain is fatty acylated before addition of sialic acid.	N-Acetylneuraminic Acid	67-78	CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)	Mus musculus	0-29
4044605-13	1985	The addition of a partially purified preparation of chick N-CAM to the membranous sialyltransferase stimulated sialic acid incorporation 3-fold.	N-Acetylneuraminic Acid	111-122	neural cell adhesion molecule 1	Gallus gallus	58-63
2864147-6	1985	Sialic acid plays an important role in both the structural pattern of the antigenic determinant and the active site of CK-BB.	N-Acetylneuraminic Acid	0-11	creatine kinase B	Homo sapiens	119-124
3906368-4	1985	Sialic acid removal by neuraminidase increased the chemiluminescent response in virulent and in reference strains.	N-Acetylneuraminic Acid	0-11	neuraminidase 1	Homo sapiens	23-36
3862894-0	1985	Organization and neuraminidase susceptibility of sialic acid residues in human melanoma cell lines with different heterotransplantabilities in nude mice.	N-Acetylneuraminic Acid	49-60	neuraminidase 1	Homo sapiens	17-30
3862894-3	1985	It was found by several methodologic approaches that the 6 human melanoma cell lines varied significantly in their amount of sialic acid susceptible to Vibrio cholerae neuraminidase, but had similar amounts of total sialic acid residues.	N-Acetylneuraminic Acid	125-136	neuraminidase 1	Homo sapiens	168-181
3906368-5	1985	Negative correlation between sialic acid content and chemiluminescence was demonstrated in strains of the same serotype, before and after passages in mouse and neuraminidase treatment for types Ic, II and III but no correlation was found considering the sialic acid content in strains belonging to different serotypes.	N-Acetylneuraminic Acid	29-40	neuraminidase 1	Homo sapiens	160-173
3903338-2	1985	We have identified a single sialoprotein - MW 140 kD - which we have called "Podocalyxin", and which is the major carrier of glomerular sialic acid.	N-Acetylneuraminic Acid	136-147	podocalyxin like	Homo sapiens	77-88
3903338-3	1985	We have shown that podocalyxin of normal rat glomeruli contains 20 sialic acid residues per molecule, whereas in aminonucleoside nephrotic glomeruli only 4-5 sialic acid per molecule are present.	N-Acetylneuraminic Acid	67-78	podocalyxin-like	Rattus norvegicus	19-30
3903338-4	1985	We conclude that the loss of histochemical staining for the "glomerular polyanion" is due both to the reduction of sialic acid per podocalyxin molecule, and to the reduction of the surface of the podocyte"s plasmalemma caused by spreading of footprocesses.	N-Acetylneuraminic Acid	115-126	podocalyxin like	Homo sapiens	131-142
2992810-5	1985	Galactose oxidase or sodium periodate only activated murine macrophages to stimulate lymphocyte IFN-gamma production after exposing D-galactose residues by the removal of the terminal N-acetyl-neuraminic acid residues with neuraminidase.	N-Acetylneuraminic Acid	184-208	interferon gamma	Mus musculus	96-105
2867024-9	1985	These results strongly suggest that the charge heterogeneity of arylsulfatase A is due not only to sialylation but also to phosphorylation at the carbohydrate moiety of the enzyme, and that the extent of substitution by acidic groups, sialic acid residue and phosphate residue, is markedly increased in the tumor enzyme.	N-Acetylneuraminic Acid	235-246	arylsulfatase A	Homo sapiens	64-79
2417829-7	1985	The affinity with Ricin-Sepharose indicated that most of the FS-alpha and some of the TM-alpha may contain terminal sialic acid and the penultimate structure, Gal beta 1----4G1cNAc; the affinity with PNA-Sepharose indicated that both may also contain terminal sialic acid and the penultimate structure, Gal beta 1----3GalNAc.	N-Acetylneuraminic Acid	116-127	bridge-like lipid transfer protein family member 1	Homo sapiens	61-69
4077019-5	1985	The total content of sialic acid in purified abnormal fibrinogen was markedly increased as compared to that in purified normal fibrinogen.	N-Acetylneuraminic Acid	21-32	fibrinogen beta chain	Homo sapiens	54-64
4077019-8	1985	It was reported by Harvey (1978) that an abnormal fibrinogen in liver diseases was similar to the fetal fibrinogen in the content of sialic acid and prolongation of thrombin time.	N-Acetylneuraminic Acid	133-144	fibrinogen beta chain	Homo sapiens	50-60
4077019-8	1985	It was reported by Harvey (1978) that an abnormal fibrinogen in liver diseases was similar to the fetal fibrinogen in the content of sialic acid and prolongation of thrombin time.	N-Acetylneuraminic Acid	133-144	fibrinogen beta chain	Homo sapiens	104-114
3896152-6	1985	Antisera specific for LS-tetrasaccharide c and 3"-sialyllactose (NeuAc alpha 2-3Gal beta 1-4Glc) identify their corresponding 3H-labeled haptens released from the major meconium gangliosides 6"-LM1 and GM3, respectively.	N-Acetylneuraminic Acid	65-70	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	84-90
4019580-1	1985	During normal development, the neural cell adhesion molecule N-CAM changes at the cell-surface from a sialic acid-rich embryonic, or E form, to several adult, or A forms that have less sialic acid (E-to-A conversion).	N-Acetylneuraminic Acid	102-113	neural cell adhesion molecule 1	Gallus gallus	61-66
4019580-1	1985	During normal development, the neural cell adhesion molecule N-CAM changes at the cell-surface from a sialic acid-rich embryonic, or E form, to several adult, or A forms that have less sialic acid (E-to-A conversion).	N-Acetylneuraminic Acid	185-196	neural cell adhesion molecule 1	Gallus gallus	61-66
4008485-3	1985	The neutral mucin (less than 1.0 mol % sialic acid) was the major species (greater than 80% by weight) and contained a higher molar proportion of fucose, galactose, and N-acetylglucosamine, and a lower proportion of sialic acid and N-acetylgalactosamine than the acidic species (greater than 10 mol % sialic acid).	N-Acetylneuraminic Acid	39-50	LOC100508689	Homo sapiens	12-17
4008485-3	1985	The neutral mucin (less than 1.0 mol % sialic acid) was the major species (greater than 80% by weight) and contained a higher molar proportion of fucose, galactose, and N-acetylglucosamine, and a lower proportion of sialic acid and N-acetylgalactosamine than the acidic species (greater than 10 mol % sialic acid).	N-Acetylneuraminic Acid	216-227	LOC100508689	Homo sapiens	12-17
4008485-3	1985	The neutral mucin (less than 1.0 mol % sialic acid) was the major species (greater than 80% by weight) and contained a higher molar proportion of fucose, galactose, and N-acetylglucosamine, and a lower proportion of sialic acid and N-acetylgalactosamine than the acidic species (greater than 10 mol % sialic acid).	N-Acetylneuraminic Acid	216-227	LOC100508689	Homo sapiens	12-17
3859365-2	1985	In these studies, cells were incubated with Vibrio cholerae neuraminidase to remove surface sialic acid.	N-Acetylneuraminic Acid	92-103	neuraminidase 1	Homo sapiens	60-73
2993570-4	1985	The supernatant from activated human neutrophils, containing elastolytic activity, when perfused together with neuraminidase enhanced and prolonged sialic acid release induced by neuraminidase alone.	N-Acetylneuraminic Acid	148-159	neuraminidase 1	Homo sapiens	111-124
2993570-4	1985	The supernatant from activated human neutrophils, containing elastolytic activity, when perfused together with neuraminidase enhanced and prolonged sialic acid release induced by neuraminidase alone.	N-Acetylneuraminic Acid	148-159	neuraminidase 1	Homo sapiens	179-192
2417829-7	1985	The affinity with Ricin-Sepharose indicated that most of the FS-alpha and some of the TM-alpha may contain terminal sialic acid and the penultimate structure, Gal beta 1----4G1cNAc; the affinity with PNA-Sepharose indicated that both may also contain terminal sialic acid and the penultimate structure, Gal beta 1----3GalNAc.	N-Acetylneuraminic Acid	260-271	bridge-like lipid transfer protein family member 1	Homo sapiens	61-69
3987096-3	1985	The surface density of carboxyl group of N-acetylneuraminic acid (NANA), protein side chain epsilon-amino groups, and phosphate groups were different for the two subpopulations of CBL.	N-Acetylneuraminic Acid	41-64	Cbl proto-oncogene	Homo sapiens	180-183
3925672-11	1985	Studies with neuraminidase-treated pituitary extracts indicated that the sex- and age-dependent variations of the charge on FSH were due to differences in the sialic acid content.	N-Acetylneuraminic Acid	159-170	neuraminidase 1	Homo sapiens	13-26
3893431-4	1985	These results suggest that terminal sialic acid residues have a significant role in insulin-binding and kinase activities.	N-Acetylneuraminic Acid	36-47	insulin	Homo sapiens	84-91
4005182-4	1985	In polycythaemia vera and in chronic myeloid leukaemia the terminal sialic acid of glycoprotein IIIb was labelled slightly more than normal.	N-Acetylneuraminic Acid	68-79	CD36 molecule	Homo sapiens	83-100
2865215-5	1985	Neuraminidase digestion suggests that the pattern of Con A-binding of seminal GGT depends only partly on its sialic acid content.	N-Acetylneuraminic Acid	109-120	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	78-81
3996312-8	1985	Limited proteolysis of [3H]epo (labeled at sialic acid residues of the oligosaccharide chains) showed that it consists of two rather trypsin-resistant domains, each having a mol wt of about 16,000, connected by a small region of protein that is trypsin sensitive.	N-Acetylneuraminic Acid	43-54	erythropoietin	Homo sapiens	27-30
4024089-8	1985	The reduction in apoE-2/E-3 ratio was caused by an increase in apoE-3 band and a decrease in apoE-2 band which might be attributed to the changes in the sialic acid-content of isoproteins on the one-dimensional IEF method.	N-Acetylneuraminic Acid	153-164	apolipoprotein E	Homo sapiens	17-23
2412116-7	1985	Neuraminidase-treated cells incorporated sialic acid or its 7-carbon analog, 5-acetamido-3,5-dideoxy-L-arabino-2-heptulosonic acid (AcNeu7) from sialylated compounds such as fetuin or sialyl-lactose but did not incorporate free sialic acid.	N-Acetylneuraminic Acid	41-52	neuraminidase 1	Homo sapiens	0-13
2412116-7	1985	Neuraminidase-treated cells incorporated sialic acid or its 7-carbon analog, 5-acetamido-3,5-dideoxy-L-arabino-2-heptulosonic acid (AcNeu7) from sialylated compounds such as fetuin or sialyl-lactose but did not incorporate free sialic acid.	N-Acetylneuraminic Acid	228-239	neuraminidase 1	Homo sapiens	0-13
4024089-8	1985	The reduction in apoE-2/E-3 ratio was caused by an increase in apoE-3 band and a decrease in apoE-2 band which might be attributed to the changes in the sialic acid-content of isoproteins on the one-dimensional IEF method.	N-Acetylneuraminic Acid	153-164	small nucleolar RNA, H/ACA box 63	Homo sapiens	24-27
4024089-8	1985	The reduction in apoE-2/E-3 ratio was caused by an increase in apoE-3 band and a decrease in apoE-2 band which might be attributed to the changes in the sialic acid-content of isoproteins on the one-dimensional IEF method.	N-Acetylneuraminic Acid	153-164	apolipoprotein E	Homo sapiens	93-99
2411164-7	1985	Fetuin and transferrin were detected by Ricinus communis agglutinin or peanut agglutinin after removal of sialic acid by treatment with neuraminidase or by weak-acid hydrolysis.	N-Acetylneuraminic Acid	106-117	alpha-2-HS-glycoprotein	Ovis aries	0-6
2411164-7	1985	Fetuin and transferrin were detected by Ricinus communis agglutinin or peanut agglutinin after removal of sialic acid by treatment with neuraminidase or by weak-acid hydrolysis.	N-Acetylneuraminic Acid	106-117	LOW QUALITY PROTEIN: serotransferrin	Ovis aries	11-22
3985042-3	1985	This report describes the clinical course of a patient who at the time of diagnosis of nonmetastatic renal cell carcinoma had dysfibrinogenemia characterized by prolongation of the thrombin and Reptilase times and increased sialic acid content of the purified fibrinogen.	N-Acetylneuraminic Acid	224-235	fibrinogen beta chain	Homo sapiens	129-139
4028045-2	1985	The role of sialic acid was investigated by treating the cells with neuraminidase.	N-Acetylneuraminic Acid	12-23	neuraminidase 1	Homo sapiens	68-81
4014527-7	1985	Removal of surface sialic acid by neuraminidase treatment of the trophoblast cells had little effect on the susceptibility of these cells to unstimulated NK cells (one of four experiments), but resulted in susceptibility to IF-boosted NK cells in four of four experiments.	N-Acetylneuraminic Acid	19-30	neuraminidase 1	Homo sapiens	34-47
2408994-4	1985	However, the sialic acid content of MS alpha 2M was found to be significantly higher than that of normal alpha 2M.	N-Acetylneuraminic Acid	13-24	alpha-2-macroglobulin	Homo sapiens	39-47
2985503-3	1985	The receptor on injured tracheal cells contains n-acetylneuraminic acid as the principal sugar, but the structure of the receptor in mucin has not been described.	N-Acetylneuraminic Acid	48-71	LOC100508689	Homo sapiens	133-138
2985503-10	1985	Our results suggest that n-acetylglucosamine and n-acetylneuraminic acid are important constituents of the binding sites for P. aeruginosa on human tracheobronchial mucin.	N-Acetylneuraminic Acid	49-72	LOC100508689	Homo sapiens	165-170
2412109-2	1985	Results with enzyme-modified erythrocytes indicated the MoAb31 determinants were sialic acid dependent, and resided on glycophorin A on the trypsin-resistant, ficin-sensitive segment, and on glycophorin B on the ficin-sensitive segment.	N-Acetylneuraminic Acid	81-92	glycophorin A (MNS blood group)	Homo sapiens	119-132
4004985-9	1985	Reductions of 42% on the LDL sialic acid content, by neuraminidase treatment, induced a 10-fold increment in their avidity for the lipoprotein complexing proteoglycan.	N-Acetylneuraminic Acid	29-40	neuraminidase 1	Homo sapiens	53-66
3976840-3	1985	Purified podocalyxin from both control and PAN rats was found to contain sialic acid, Gal, GlcNac, and Man but lacked Fuc and GalNac by gas-liquid chromatography.	N-Acetylneuraminic Acid	73-84	podocalyxin-like	Rattus norvegicus	9-20
3920855-2	1985	The molecule contains approximately 10 sialic acid residues which play a key role in the peripheral metabolism of TBG.	N-Acetylneuraminic Acid	39-50	serpin family A member 7	Homo sapiens	114-117
3976840-4	1985	In PAN rats the sialic acid content of podocalyxin was reduced from 4.5% to 1.5%, whereas the concentration of the other sugars (with the possible exception of Gal) was similar to that of controls.	N-Acetylneuraminic Acid	16-27	podocalyxin-like	Rattus norvegicus	39-50
3976840-6	1985	These data indicate that the reduced total glomerular sialic acid content found in PAN is due to the combined effects of the decreased podocyte plasmalemmal surface area and the reduced sialic acid content of podocalyxin.	N-Acetylneuraminic Acid	54-65	podocalyxin-like	Rattus norvegicus	209-220
3976840-6	1985	These data indicate that the reduced total glomerular sialic acid content found in PAN is due to the combined effects of the decreased podocyte plasmalemmal surface area and the reduced sialic acid content of podocalyxin.	N-Acetylneuraminic Acid	186-197	podocalyxin-like	Rattus norvegicus	209-220
3855439-0	1985	A lectinlike receptor on murine macrophage cell line cells, Mm1: involvement of sialic acid-binding sites in opsonin-independent phagocytosis for xenogeneic red cells.	N-Acetylneuraminic Acid	80-91	prefoldin 5	Mus musculus	60-63
2982885-2	1985	The sialic acid residues of the TfR glycoprotein were used to monitor transport to the Golgi complex, the site of sialyltransferases.	N-Acetylneuraminic Acid	4-15	transferrin receptor	Homo sapiens	32-35
2982885-3	1985	Surface-labeled cells were treated with neuraminidase, and readdition of sialic acid residues, monitored by isoelectric focusing of immunoprecipitated TfR, was used to assess the movement of receptor to sialyltransferase-containing compartments.	N-Acetylneuraminic Acid	73-84	transferrin receptor	Homo sapiens	151-154
2981927-7	1985	These findings indicate that sialic acid residues on the PMN surface membrane play an important role in modulating PMN responses to FMLP.	N-Acetylneuraminic Acid	29-40	formyl peptide receptor 1	Homo sapiens	132-136
3855439-7	1985	In contrast to these findings on Mm1 cells, binding components of QRC were sensitive to periodate oxidation or neuraminidase treatment but resistant to protease, suggesting that the terminal sialic acid residues of carbohydrate of QRC are recognized by Mm1 cells.	N-Acetylneuraminic Acid	191-202	prefoldin 5	Mus musculus	253-256
3871874-3	1985	The gp 160 consists of a single peptide chain rich in sialic acid residues (10% of total molecular weight) and has an acidic isoelectric point.	N-Acetylneuraminic Acid	54-65	leucyl/cystinyl aminopeptidase	Mus musculus	4-10
3855439-9	1985	N-Acetylneuramin lactose (Neu-NAc-Lact) was more efficient in rosette inhibition than NeuNAc.	N-Acetylneuraminic Acid	86-92	neuraminidase 1	Mus musculus	26-29
3871874-4	1985	The amino acid composition of gp 160 is compatible with the linkage of carbohydrates (galactose, glucosamine, and sialic acid) to the protein portion.	N-Acetylneuraminic Acid	114-125	leucyl/cystinyl aminopeptidase	Mus musculus	30-36
3855439-9	1985	N-Acetylneuramin lactose (Neu-NAc-Lact) was more efficient in rosette inhibition than NeuNAc.	N-Acetylneuraminic Acid	86-92	NLR family, pyrin domain containing 1A	Mus musculus	30-33
2981878-8	1985	Removal of sialic acid by neuraminidase simplified the pattern of theta spots into three distinct Ii-related polypeptides.	N-Acetylneuraminic Acid	11-22	neuraminidase 1	Homo sapiens	26-39
3917866-0	1985	Glycolipid receptor for human migration inhibitory factor: fucose and sialic acid are important for the human monocyte response to migration inhibitory factor.	N-Acetylneuraminic Acid	70-81	macrophage migration inhibitory factor	Homo sapiens	30-57
3918040-3	1985	The sialic acid content of MAT-C1 ASGP-1 is 2-3-fold greater than MAT-B1 ASGP-1 (Sherblom, A. P., Buck, R. L., and Carraway, K. L. (1980) J. Biol.	N-Acetylneuraminic Acid	4-15	mucin 4, cell surface associated	Rattus norvegicus	34-40
3917866-0	1985	Glycolipid receptor for human migration inhibitory factor: fucose and sialic acid are important for the human monocyte response to migration inhibitory factor.	N-Acetylneuraminic Acid	70-81	macrophage migration inhibitory factor	Homo sapiens	131-158
3917866-2	1985	When monocytes were pretreated with neuraminidase, an exoglycosidase specific for sialic acid, they became unresponsive to MIF.	N-Acetylneuraminic Acid	82-93	neuraminidase 1	Homo sapiens	36-49
3917866-6	1985	This suggests the importance of terminal sialic acid and fucose residues for the interaction between monocyte membrane glycolipids and MIF.	N-Acetylneuraminic Acid	41-52	macrophage migration inhibitory factor	Homo sapiens	135-138
3919387-2	1985	This system, which is based on the autoimmune NZB mouse strain, has been used to produce a monoclonal IgG2a antibody against the meningococcus group B and Escherichia coli K1 polysaccharides, identical homopolymers of alpha (2----8)-linked units of N-acetylneuraminic acid that are extremely poor immunogens.	N-Acetylneuraminic Acid	249-272	immunoglobulin heavy variable V1-9	Mus musculus	102-107
4039604-6	1985	IRBP contains neutral sugar, including fucose, and sialic acid; the glycoprotein nature of the proteins probably accounts for the microheterogeneity observed in the electrofocusing pattern of both bovine and monkey IRBP.	N-Acetylneuraminic Acid	51-62	retinol binding protein 3	Bos taurus	0-4
3967951-4	1985	Neuraminidase treatment of the glycopeptides indicates that only gp87 contains accessible sialic acid moieties.	N-Acetylneuraminic Acid	90-101	neuraminidase 1	Homo sapiens	0-13
3893876-3	1985	The results suggest that the insulin receptor on rat adipocytes contains sialic acid in its carbohydrate moiety but does not possess non-reducing alpha-D-galactopyranosyl or 2-acetamido-2-deoxy-alpha-D-galactopyranosyl end groups.	N-Acetylneuraminic Acid	73-84	insulin receptor	Rattus norvegicus	29-45
3967040-2	1985	The mucin contained 11% carbohydrate, largely as glucosamine, galactose and N-acetylneuraminic acid, and 19% lipid, of which 86% was unesterified fatty acid.	N-Acetylneuraminic Acid	76-99	LOC100508689	Homo sapiens	4-9
2856899-13	1985	However, the released CEA contains species with higher isoelectric points, suggesting that perhaps the removal of sialic acid and the resulting exposure of galactose residues mediate the subsequent transfer to the hepatocyte.	N-Acetylneuraminic Acid	114-125	CEA cell adhesion molecule 20	Rattus norvegicus	22-25
3965464-5	1985	Carbohydrate determination revealed the sole detectable structural difference in the two antithrombins: levels of hexosamine, neutral sugars, and sialic acid in AT-III beta were all 25-30% less than in AT-III alpha.	N-Acetylneuraminic Acid	146-157	serpin family C member 1	Homo sapiens	161-167
4030024-3	1985	Both neutrophil inhibitory and hemolytic activities appear to be a function of the peptide portion of SAP (determined by sensitivity to trypsin and pronase), which is augmented by the presence of sialic acid in the complex (activity eliminated by the addition of neuraminidase).	N-Acetylneuraminic Acid	196-207	SH2 domain containing 1A	Homo sapiens	102-105
4053569-3	1985	Quantitative determination of the sialic acid content shows that there are two sialic acid residues per molecule of Macaca transferrin.	N-Acetylneuraminic Acid	34-45	INHCAP	Macaca fascicularis	123-134
4053569-3	1985	Quantitative determination of the sialic acid content shows that there are two sialic acid residues per molecule of Macaca transferrin.	N-Acetylneuraminic Acid	79-90	INHCAP	Macaca fascicularis	123-134
4038970-3	1985	The results indicate that both proteins, the anodal and the cathodal component of these Gc1 mutants, carry sialic acid residues.	N-Acetylneuraminic Acid	107-118	olfactomedin 4	Homo sapiens	88-91
4030024-3	1985	Both neutrophil inhibitory and hemolytic activities appear to be a function of the peptide portion of SAP (determined by sensitivity to trypsin and pronase), which is augmented by the presence of sialic acid in the complex (activity eliminated by the addition of neuraminidase).	N-Acetylneuraminic Acid	196-207	neuraminidase 1	Homo sapiens	263-276
3858613-0	1985	Regeneration of membrane sialic acid after neuraminidase treatment of leukemic granulocytes.	N-Acetylneuraminic Acid	25-36	neuraminidase 1	Homo sapiens	43-56
3858613-1	1985	Granulocytes from patients with chronic myelogenous leukemia (CML) were studied for their ability to regenerate surface sialic acid following treatment with Vibrio cholera neuraminidase (VCN) in vitro.	N-Acetylneuraminic Acid	120-131	neuraminidase 1	Homo sapiens	172-185
3858613-3	1985	CML granulocytes treated with neuraminidase then incubated for 18 h in nutrient medium showed strikingly increased PI/BH3(4) labelling, usually greater than initial pretreatment values, consistent with a rapid reappearance of sialic acid in the cell membrane.	N-Acetylneuraminic Acid	226-237	neuraminidase 1	Homo sapiens	30-43
3965860-3	1985	These observations have prompted the notion that sialic acid in VLDL may impede LPL or receptor-mediated clearance of VLDL and thus result in hypertriglyceridemia.	N-Acetylneuraminic Acid	49-60	lipoprotein lipase	Homo sapiens	80-83
6543331-0	1984	Sialic acid-deficient serum and cerebrospinal fluid transferrin in a newly recognized genetic syndrome.	N-Acetylneuraminic Acid	0-11	transferrin	Homo sapiens	52-63
3931095-1	1985	Pronase digestion of IRBP yielded one major glycopeptide (IRBP-GP1) of approximate Mr 2,500 IRBP-GP1 was heterogeneous by anion exchange chromatography, an observation that was attributed to the presence of varying numbers of sialic acid residues.	N-Acetylneuraminic Acid	226-237	retinol binding protein 3	Bos taurus	21-25
3931095-1	1985	Pronase digestion of IRBP yielded one major glycopeptide (IRBP-GP1) of approximate Mr 2,500 IRBP-GP1 was heterogeneous by anion exchange chromatography, an observation that was attributed to the presence of varying numbers of sialic acid residues.	N-Acetylneuraminic Acid	226-237	retinol binding protein 3	Bos taurus	58-62
3931095-1	1985	Pronase digestion of IRBP yielded one major glycopeptide (IRBP-GP1) of approximate Mr 2,500 IRBP-GP1 was heterogeneous by anion exchange chromatography, an observation that was attributed to the presence of varying numbers of sialic acid residues.	N-Acetylneuraminic Acid	226-237	retinol binding protein 3	Bos taurus	58-62
3983959-4	1985	The experiments yielded results leading to the following conclusions: Cell surface sialic acid can be exclusively recovered at consistent rates by treatment of lymphocytes with 0.1 IU of neuraminidase in the presence of Ca++ at 37 degrees C for 30 min.	N-Acetylneuraminic Acid	83-94	neuraminidase 1	Homo sapiens	187-200
3983959-7	1985	Surface sialic acid on lymphocytes cultured at 37 degrees C after treatment with neuraminidase was resynthesized sufficiently at about 6 hr.	N-Acetylneuraminic Acid	8-19	neuraminidase 1	Homo sapiens	81-94
6439249-6	1984	Neuraminidase digestion studies have shown that at least part of this charge heterogeneity may be due to sialic acid residues.	N-Acetylneuraminic Acid	105-116	neuraminidase 1	Homo sapiens	0-13
6439079-14	1984	In contrast to adult lactase, fetal lactase contains sialic acid at the end of carbohydrate side chains.	N-Acetylneuraminic Acid	53-64	lactase	Homo sapiens	36-43
6526824-4	1984	This view was also supported by the almost exclusive addition of the terminal sugars such as N-acetylglucosamine, galactose, and sialic acid in GF1.	N-Acetylneuraminic Acid	129-140	GATA binding protein 1	Rattus norvegicus	144-147
6152147-10	1984	Incubation with neuraminidase rendered the amidase more basic suggesting the release of sialic acid residues.	N-Acetylneuraminic Acid	88-99	AT695_RS13185	Staphylococcus aureus	43-50
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	N-Acetylneuraminic Acid	15-20	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	35-41
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	N-Acetylneuraminic Acid	15-20	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	51-59
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	N-Acetylneuraminic Acid	15-20	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	51-57
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	N-Acetylneuraminic Acid	15-20	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	51-57
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	N-Acetylneuraminic Acid	15-20	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	51-57
6333424-6	1984	The forward rate constant could be increased by removing Fc from the antibody or by removing sialic acid from the cells by treatment with neuraminidase.	N-Acetylneuraminic Acid	93-104	neuraminidase 1	Homo sapiens	138-151
6386229-3	1984	Using thiobarbituric acid as the chromophore, I measured sialic acid in the PTA precipitate after overnight treatment with neuraminidase.	N-Acetylneuraminic Acid	57-68	neuraminidase 1	Homo sapiens	123-136
6387049-5	1984	This switch can be mimicked by neuraminidase treatment, suggesting a developmental loss of sialic acid from the D2 protein.	N-Acetylneuraminic Acid	91-102	neuraminidase 1	Homo sapiens	31-44
6437459-0	1984	Effects of variant gamma chains and sialic acid content of fibrinogen upon its interactions with ADP-stimulated human and rabbit platelets.	N-Acetylneuraminic Acid	36-47	fibrinogen beta chain	Homo sapiens	59-69
6437459-3	1984	Normal human fibrinogen, which consists of three pairs of disulfide-bonded peptide chains, (A alpha, B beta, gamma)2, is heterogeneous with respect to sialic acid content and also contains a small proportion of molecules with a variant gamma chain (designated gamma"), elongated by a peptide extension at the COOH-terminus of the normal gamma chain.	N-Acetylneuraminic Acid	151-162	fibrinogen beta chain	Homo sapiens	13-23
6437459-7	1984	We conclude that the sialic acid content of fibrinogen does not significantly affect its interactions with platelets, but the elongated gamma" chains bind less effectively to ADP-stimulated platelets, and thus reduce the ability of fibrinogen to support aggregation.	N-Acetylneuraminic Acid	21-32	fibrinogen beta chain	Homo sapiens	44-54
6386828-2	1984	In order to understand the mechanism of these changes, a cyanogen bromide (CNBr) fragment that contained 90% of the sialic acid of N-CAM was isolated and characterized according to the number of carbohydrate attachment sites and reactivity with specific monoclonal antibodies.	N-Acetylneuraminic Acid	116-127	neural cell adhesion molecule 1	Homo sapiens	131-136
6386828-5	1984	The fragment reacted with monoclonal antibody 15G8, which detects the sialic acid in embryonic N-CAM, and with a monoclonal antibody, anti-(N-CAM) No.	N-Acetylneuraminic Acid	70-81	neural cell adhesion molecule 1	Homo sapiens	95-100
6386828-9	1984	A similar CNBr sialopeptide was obtained from adult N-CAM; it contained sialic acid, had three N-linked oligosaccharides and reacted with anti-(N-CAM) No.	N-Acetylneuraminic Acid	72-83	neural cell adhesion molecule 1	Homo sapiens	52-57
6386828-15	1984	These data confirm that the majority of the sialic acid is localized in the middle region of the N-CAM molecule and support the hypothesis that embryonic to adult conversion of N-CAM is the result of differences in sialidase or sialytransferase activity.	N-Acetylneuraminic Acid	44-55	neural cell adhesion molecule 1	Homo sapiens	97-102
6386828-15	1984	These data confirm that the majority of the sialic acid is localized in the middle region of the N-CAM molecule and support the hypothesis that embryonic to adult conversion of N-CAM is the result of differences in sialidase or sialytransferase activity.	N-Acetylneuraminic Acid	44-55	neural cell adhesion molecule 1	Homo sapiens	177-182
6592604-8	1984	CNBr digests of neuraminidase-treated enzymes reveal a change of mobility of only one CNBr band in each of fetal intestinal, placental, and liver ALPases, indicating the presence of sialic acid residues in these fragments.	N-Acetylneuraminic Acid	182-193	neuraminidase 1	Homo sapiens	16-29
6208560-1	1984	The neural cell adhesion molecule N-CAM is a sialic acid-rich, cell surface glycoprotein that mediates cell adhesion by a homophilic mechanism.	N-Acetylneuraminic Acid	45-56	neural cell adhesion molecule 1	Gallus gallus	34-39
6520127-4	1984	GM1 gangliosides containing either N-glycolylneuraminic acid or N-acetylneuraminic acid were also purified and characterized by thin layer chromatography, sugar analysis and sialidase treatment.	N-Acetylneuraminic Acid	64-87	coenzyme Q10A	Mus musculus	0-3
6148948-6	1984	However, after treatment with neuraminidase to remove sialic acid, their respective mobilities were similar.	N-Acetylneuraminic Acid	54-65	neuraminidase 1	Homo sapiens	30-43
6517312-4	1984	Sialic acid could be estimated as N-acylhexosamines produced by the action of N-acetylneuraminate pyruvate-lyase.	N-Acetylneuraminic Acid	0-11	N-acetylneuraminate pyruvate lyase	Homo sapiens	78-112
6478625-0	1984	Sialic acid residues contribute to the heterogeneity of human serum ribonuclease: demonstration by isoelectric focusing and neuraminidase treatment of serum.	N-Acetylneuraminic Acid	0-11	neuraminidase 1	Homo sapiens	124-137
6481966-5	1984	Serum TPA levels correlated well with those of alpha 1-ACT, IAP and ASP in stomach cancer patients and with those of CEA, ASP and sialic acid in colon cancer, but not in esophageal cancer patients.	N-Acetylneuraminic Acid	130-141	plasminogen activator, tissue type	Homo sapiens	6-9
6477648-8	1984	These results suggest that bovine adrenal phenylethanolamine N-methyltransferase is a glycosylated protein, containing sialic acid moieties, and that this carbohydrate moiety plays a role in the activation of this enzyme.	N-Acetylneuraminic Acid	119-130	phenylethanolamine N-methyltransferase	Bos taurus	42-80
6542100-5	1984	This agglutinin was shown to have multimeric activity towards different kinds of erythrocytes and its hemagglutinating activity was inhibited by N-acetylamino sugars and bovine submaxillary gland mucin containing sialic acid.	N-Acetylneuraminic Acid	213-224	mucin 1, cell surface associated	Bos taurus	196-201
6481452-2	1984	In the case of the neural cell adhesion molecule (N-CAM), it has been found that during development the molecule is converted from a microheterogeneous embryonic (E) form containing 30 gm of sialic acid/100 gm of polypeptide to several distinct adult (A) forms containing one third as much of this sugar.	N-Acetylneuraminic Acid	191-202	neural cell adhesion molecule 1	Mus musculus	19-48
6481452-2	1984	In the case of the neural cell adhesion molecule (N-CAM), it has been found that during development the molecule is converted from a microheterogeneous embryonic (E) form containing 30 gm of sialic acid/100 gm of polypeptide to several distinct adult (A) forms containing one third as much of this sugar.	N-Acetylneuraminic Acid	191-202	neural cell adhesion molecule 1	Mus musculus	50-55
6477508-7	1984	Neuraminidase treatment at the whole-cell level, before homogenization, which is an essential requirement for good resolution of the two membrane subfractions, modifies a number of the glycoprotein subunits with respect to their pI characteristics, suggesting much molecular micro-heterogeneity with respect to sialic acid content.	N-Acetylneuraminic Acid	311-322	neuraminidase 1	Homo sapiens	0-13
6378369-5	1984	Removal of sialic acid from the gangliosides by neuraminidase treatment significantly reduced or abolished their inhibitory effect.	N-Acetylneuraminic Acid	11-22	neuraminidase 1	Homo sapiens	48-61
6204209-2	1984	N-CAM has an unusual carbohydrate moiety containing a large and variable amount of sialic acid, the variation reflecting both the type of tissue and its developmental age.	N-Acetylneuraminic Acid	83-94	neural cell adhesion molecule 1	Gallus gallus	0-5
6743688-3	1984	The solubilized neuraminidase activity is extremely labile, but can be stabilized for at least 4 weeks at 2-4 degrees C, using 10 mM N-acetylneuraminic acid.	N-Acetylneuraminic Acid	133-156	neuraminidase 1	Homo sapiens	16-29
6589212-4	1984	This heterogeneity was shown by neuraminidase treatment of the immune precipitates to be due to variations in sialic acid content of the antigens since, in five of the six cell lines tested, such treatment produced homogeneous material of apparent molecular weight 55,000.	N-Acetylneuraminic Acid	110-121	neuraminidase 1	Homo sapiens	32-45
6204209-3	1984	N-CAM is believed to be a ligand in the formation of cell-cell bonds and a decrease in sialic acid content from 30% to 10% is associated with a marked enhancement of the molecule"s binding activity.	N-Acetylneuraminic Acid	87-98	neural cell adhesion molecule 1	Gallus gallus	0-5
6204209-6	1984	The results indicate that N-CAM from the retina of 5-10-day-old embryos already exists in a relatively sialic acid-poor form, whereas the tectum and optic nerve beyond the eye contain sialic acid-rich N-CAM until much later in development.	N-Acetylneuraminic Acid	103-114	neural cell adhesion molecule 1	Gallus gallus	26-31
6204209-6	1984	The results indicate that N-CAM from the retina of 5-10-day-old embryos already exists in a relatively sialic acid-poor form, whereas the tectum and optic nerve beyond the eye contain sialic acid-rich N-CAM until much later in development.	N-Acetylneuraminic Acid	184-195	neural cell adhesion molecule 1	Gallus gallus	26-31
6431895-2	1984	Electrophoretic studies have shown that the same enzymes and the non-lysosomal adenosine deaminase also show excess terminal sialic acid in patients deficient in sialidase.	N-Acetylneuraminic Acid	125-136	adenosine deaminase	Homo sapiens	79-98
6204209-7	1984	These studies suggest that the perikaryon and proximal axon shaft of retinoganglion cells have N-CAM with a lower sialic acid content than the distal portion of the axons, and that resulting differences in neurite adhesivity may be an important factor in the formation of the optic system.	N-Acetylneuraminic Acid	114-125	neural cell adhesion molecule 1	Gallus gallus	95-100
6724571-3	1984	In primary breast cancers this structure is almost totally cryptic, due to "masking" by sialic acid, but can be revealed by digestion with the specific glycosidase neuraminidase.	N-Acetylneuraminic Acid	88-99	neuraminidase 1	Homo sapiens	164-177
6205441-0	1984	An abnormal fibrinogen (Copenhagen II) with increased sialic acid content associated with thrombotic tendency and normal liver function.	N-Acetylneuraminic Acid	54-65	fibrinogen beta chain	Homo sapiens	12-22
6205441-1	1984	An increased sialic acid content of the fibrinogen molecule is found in foetal fibrinogen and as an acquired disorder in hepatic disease.	N-Acetylneuraminic Acid	13-24	fibrinogen beta chain	Homo sapiens	40-50
6205441-1	1984	An increased sialic acid content of the fibrinogen molecule is found in foetal fibrinogen and as an acquired disorder in hepatic disease.	N-Acetylneuraminic Acid	13-24	fibrinogen beta chain	Homo sapiens	79-89
6205441-3	1984	The purified fibrinogen had a significantly increased content of sialic acid, an abnormal fibrin monomer polymerization, and a changed mobility in crossed affinity-immunoelectrophoresis using immobilized helix pomatia lectin.	N-Acetylneuraminic Acid	65-76	fibrinogen beta chain	Homo sapiens	13-23
6205441-5	1984	The occurrence of a thrombotic tendency and an increased fibrinogen sialic acid content without signs of liver disease may represent a new variant of congenital dysfibrinogenaemia.	N-Acetylneuraminic Acid	68-79	fibrinogen beta chain	Homo sapiens	57-67
6329948-5	1984	Incubation with unaggregated hs-Ig has a similar effect, thus providing evidence that the loss of sialic acid residues per se is enough to render these molecules capable of decreasing the MPO content of phagocytic cells.	N-Acetylneuraminic Acid	98-109	myeloperoxidase	Homo sapiens	188-191
6093076-9	1984	Neuraminidase treatment reduced the molecular weight of the placental enzyme to approximately 90,000, indicating that it contains a large amount of sialic acid.	N-Acetylneuraminic Acid	148-159	neuraminidase 1	Homo sapiens	0-13
6467084-1	1984	Clusterin, a cell aggregating factor isolated from ram rete testis fluid (RTF), is shown to contain 14.7% hexoses, 13.6% glucosamine, and 7.9% sialic acid.	N-Acetylneuraminic Acid	143-154	clusterin	Rattus norvegicus	0-9
6204642-5	1984	They react with the NeuAc(alpha 2-3)Gal(beta 1-4)Glc/GlcNAc sequence as found in GM3 and in glycolipids of the neolacto series, but show a preference for the latter, longer sequences.	N-Acetylneuraminic Acid	20-25	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	40-46
6547160-4	1984	When tested on peanut lectin, which shows specificity for the disaccharide Gal beta 1-3GalNAc, gpL115 is nonadherent and sialidase-treated gpL115 is adherent, indicating the presence of the sequence sialic acid-Gal beta 1-3GalNAc, which is characteristic for O-linked (mucin-type, acidic-type) carbohydrates.	N-Acetylneuraminic Acid	199-210	sialophorin	Homo sapiens	95-101
6427217-6	1984	IRBP contains 8.4% by weight of carbohydrate, which consists of sialic acid, neutral hexoses, and glucosamine in the molar ratio of approximately 1:3:2.	N-Acetylneuraminic Acid	64-75	retinol binding protein 3	Bos taurus	0-4
6325438-6	1984	Comparison of co-translationally modified apo-E with intracellular, secreted, and plasma forms indicates that after the intracellular cleavage of the signal peptide, the protein is glycosylated with carbohydrate chains containing sialic acid, secreted as sialoapo-E (apo-Es), and subsequently desialated in plasma.	N-Acetylneuraminic Acid	230-241	apolipoprotein E	Homo sapiens	42-47
6377946-5	1984	Prolonged, heavy alcohol consumption, as shown by others, results in the appearance of sialic acid-deficient transferrin (two residues missing) in human serum.	N-Acetylneuraminic Acid	87-98	transferrin	Rattus norvegicus	109-120
6377946-6	1984	We suggest that the increased capacity of transferrin deficient in sialic acid to selectively deposit iron in the hepatocyte may be of significance for the development of the hepatic siderosis observed in alcoholism.	N-Acetylneuraminic Acid	67-78	transferrin	Rattus norvegicus	42-53
6727057-7	1984	The amount of sialic acid in MNC, which was 1.4 times more than that in PMN, revealed a tendency for a positive correlation between neuraminidase activity.	N-Acetylneuraminic Acid	14-25	neuraminidase 1	Homo sapiens	132-145
6608726-2	1984	After neuraminidase treatment, the O-linked carbohydrate is susceptible to digestion with an endoglycosidase (endo-beta-N-acetylgalactosaminidase) that cleaves glycans with the structure Gal(beta 1----3)-GalNAc-Ser/Thr, and sialic acid can be added back to this core oligosaccharide by specific sialyltransferases.	N-Acetylneuraminic Acid	224-235	neuraminidase 1	Homo sapiens	6-19
6732768-2	1984	The corresponding disialo derivative (GD3) is found as a minor component (2-6% of total sialic acid) in the membranes of these cells.	N-Acetylneuraminic Acid	88-99	GRDX	Homo sapiens	38-41
6732768-3	1984	In human melanoma cells, grown in tissue culture, GD3 is the predominant ganglioside component (48-63% of total sialic acid).	N-Acetylneuraminic Acid	112-123	GRDX	Homo sapiens	50-53
6719540-6	1984	Another was a major sialoglycoprotein (gp80) that was identified by chemical labeling of cell surface sialic acid residues and showed decreased amounts on the more metastatic clones.	N-Acetylneuraminic Acid	102-113	glycoprotein 2	Rattus norvegicus	39-43
6729777-5	1984	In addition, the effects of citrate on the clotting of purified, calcium-free fibrinogen from cirrhotic patients correlated with the sialic acid content.	N-Acetylneuraminic Acid	133-144	fibrinogen beta chain	Homo sapiens	78-88
6729777-6	1984	It is concluded that binding of citrate ions to fibrinogen renders the molecule acutely more sensitive to elevations in the sialic acid content, and that a simple plasma clot opacity test in the presence of excess citrate may be a useful aid in the differential diagnosis of liver disease.	N-Acetylneuraminic Acid	124-135	fibrinogen beta chain	Homo sapiens	48-58
6608959-1	1984	The sialic acid residues were removed from asparagine-linked sugar chains on the C-terminal non-collagenous globular regions of human C1q by sialidase digestion.	N-Acetylneuraminic Acid	4-15	complement C1q A chain	Homo sapiens	134-137
6371806-4	1984	The developmentally regulated disappearance in poly(sialic acid) is consistent with the probes described here recognizing the polysialosyl carbohydrate units of a neuronal cell adhesion molecule (N-CAM).	N-Acetylneuraminic Acid	52-63	neuronal cell adhesion molecule	Rattus norvegicus	163-194
6371806-4	1984	The developmentally regulated disappearance in poly(sialic acid) is consistent with the probes described here recognizing the polysialosyl carbohydrate units of a neuronal cell adhesion molecule (N-CAM).	N-Acetylneuraminic Acid	52-63	neuronal cell adhesion molecule	Rattus norvegicus	196-201
6698805-7	1984	The fractions differed significantly from one another with respect to the neuraminidase susceptibility of their sialic acids (P less than 0.01), the percentage of C4 (P less than 0.01) and side-chain substituted sialic acids (P less than 0.05), and the molar fucose-sialic acid ratio (P less than 0.05).	N-Acetylneuraminic Acid	112-123	neuraminidase 1	Homo sapiens	74-87
6422851-1	1984	Sequential digestion of human thrombin and antithrombin with neuraminidase, beta-galactosidase, beta-N-acetylglucosaminidase, and endo-beta-N-acetylglucosaminidase D resulted in the successive removal of sialic acid, galactose, N-acetylglucosamine, and mannose and more N-acetylglucosamine residues.	N-Acetylneuraminic Acid	204-215	O-GlcNAcase	Homo sapiens	96-124
6422851-1	1984	Sequential digestion of human thrombin and antithrombin with neuraminidase, beta-galactosidase, beta-N-acetylglucosaminidase, and endo-beta-N-acetylglucosaminidase D resulted in the successive removal of sialic acid, galactose, N-acetylglucosamine, and mannose and more N-acetylglucosamine residues.	N-Acetylneuraminic Acid	204-215	O-GlcNAcase	Homo sapiens	135-163
6741732-7	1984	Lower incorporation of newly synthesized sialic acid into GM1 than that of other sugars may indicate reutilization of sialic acid at about 50%.	N-Acetylneuraminic Acid	41-52	coenzyme Q10A	Mus musculus	58-61
6146317-2	1984	Sialic acid residues only partially account for this enzyme multiplicity since neuraminidase treatment reduces the number of bands to three.	N-Acetylneuraminic Acid	0-11	neuraminidase 1	Homo sapiens	79-92
6363072-1	1984	An intramolecular turnover of the terminal carbohydrates L-fucose, N-acetylneuraminic acid and D-galactose is a characteristic property of several liver plasma membrane glycoproteins, first demonstrated for dipeptidylaminopeptidase IV (EC 3.4.14.5., DPP IV).	N-Acetylneuraminic Acid	67-90	dipeptidylpeptidase 4	Rattus norvegicus	250-256
6319581-3	1984	Digestion studies with neuraminidase and oligosaccharidase have indicated that the molecule is heavily sialated with most of the sialic acid located on the O-linked sugars.	N-Acetylneuraminic Acid	129-140	neuraminidase 1	Homo sapiens	23-36
6430047-15	1984	The result suggests that WHT/Ht has N-acetylgalactosaminyltransferase to convert GM3 (NeuAc) to GM2 (NeuAc) in its brain.	N-Acetylneuraminic Acid	86-91	beta-1,4-N-acetyl-galactosaminyl transferase 2	Mus musculus	36-69
6430047-15	1984	The result suggests that WHT/Ht has N-acetylgalactosaminyltransferase to convert GM3 (NeuAc) to GM2 (NeuAc) in its brain.	N-Acetylneuraminic Acid	86-91	granulocyte macrophage antigen 3	Mus musculus	81-84
6430047-15	1984	The result suggests that WHT/Ht has N-acetylgalactosaminyltransferase to convert GM3 (NeuAc) to GM2 (NeuAc) in its brain.	N-Acetylneuraminic Acid	101-106	beta-1,4-N-acetyl-galactosaminyl transferase 2	Mus musculus	36-69
6208762-2	1984	On standard hCG beta there are two NeuAc residues on each N- and O-linked oligosaccharide, so that the number of NeuAc residues is proportional to the number of oligosaccharides.	N-Acetylneuraminic Acid	35-40	chorionic gonadotropin subunit beta 3	Homo sapiens	12-20
6208762-2	1984	On standard hCG beta there are two NeuAc residues on each N- and O-linked oligosaccharide, so that the number of NeuAc residues is proportional to the number of oligosaccharides.	N-Acetylneuraminic Acid	113-118	chorionic gonadotropin subunit beta 3	Homo sapiens	12-20
6430047-15	1984	The result suggests that WHT/Ht has N-acetylgalactosaminyltransferase to convert GM3 (NeuAc) to GM2 (NeuAc) in its brain.	N-Acetylneuraminic Acid	101-106	granulocyte macrophage antigen 3	Mus musculus	81-84
6741732-7	1984	Lower incorporation of newly synthesized sialic acid into GM1 than that of other sugars may indicate reutilization of sialic acid at about 50%.	N-Acetylneuraminic Acid	118-129	coenzyme Q10A	Mus musculus	58-61
6538394-2	1984	S pneumoniae neuraminidase exhibits optimum activity near neutral pH (6.0 to 6.5), and catalyzes the cleavage of sialic acid residues from glycoproteins, gangliosides and mucopolysaccharides.	N-Acetylneuraminic Acid	113-124	neuraminidase 1	Homo sapiens	13-26
6532156-2	1984	The rate of this aggregation has a high-order dependence on the local N-CAM concentration, and is inversely related to the sialic acid content of the N-CAM molecules involved.	N-Acetylneuraminic Acid	123-134	neural cell adhesion molecule 1	Homo sapiens	70-75
6532156-2	1984	The rate of this aggregation has a high-order dependence on the local N-CAM concentration, and is inversely related to the sialic acid content of the N-CAM molecules involved.	N-Acetylneuraminic Acid	123-134	neural cell adhesion molecule 1	Homo sapiens	150-155
6532156-3	1984	In accordance with their relative sialic acid concentrations, the relative rates of aggregation mediated by E and A forms of N-CAM are A-A greater than A-E greater than E-E. Further removal of sialic acid from N-CAM below the level found in the A form gives little further enhancement of aggregation.	N-Acetylneuraminic Acid	193-204	neural cell adhesion molecule 1	Homo sapiens	125-130
6532156-3	1984	In accordance with their relative sialic acid concentrations, the relative rates of aggregation mediated by E and A forms of N-CAM are A-A greater than A-E greater than E-E. Further removal of sialic acid from N-CAM below the level found in the A form gives little further enhancement of aggregation.	N-Acetylneuraminic Acid	193-204	neural cell adhesion molecule 1	Homo sapiens	210-215
6540046-4	1984	The first of these problems was approached by measuring sialic acid released (by the enzyme, neuraminidase) from gangliosides in lipid bilayers.	N-Acetylneuraminic Acid	56-67	neuraminidase 1	Homo sapiens	93-106
6607122-1	1984	A lectin-resistant variant of the murine EL4 lymphocytic leukemia cell line was selected in the presence of wheat germ agglutinin for low levels of cell-surface sialic acid.	N-Acetylneuraminic Acid	161-172	epilepsy 4	Mus musculus	41-44
6598359-5	1984	The Hyp mice fed the control diet showed a significant decrease in salivary-inorganic phosphate, total phosphate, osmotic pressure and sialic acid.	N-Acetylneuraminic Acid	135-146	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	4-7
6088317-1	1984	Preparative isoelectric focusing of human diferric transferrin preparations yielded seven bands with different isoelectric points, due to differences in sialic acid content.	N-Acetylneuraminic Acid	153-164	transferrin	Homo sapiens	51-62
6368066-3	1984	Neuraminidase may also induce sialic acid depletion that would be expected to result in changes of the electrical charge in the immune complex as well as in the glomerular polyanion filtration barrier.	N-Acetylneuraminic Acid	30-41	neuraminidase 1	Homo sapiens	0-13
6439619-2	1984	It appears that sialic acid is present in these preparations and can be released either by neuraminidase treatment of acid hydrolysis.	N-Acetylneuraminic Acid	16-27	neuraminidase 1	Homo sapiens	91-104
6418639-2	1984	Treatment of human PBLs with neuraminidase removes terminal sialic acid residues and renders them susceptible to cytotoxicity by autologous NK cells.	N-Acetylneuraminic Acid	60-71	neuraminidase 1	Homo sapiens	29-42
6539264-8	1984	The neuraminidase-accessible sialic acid of LM12 -3-II cells was less than that of P-29 cells.	N-Acetylneuraminic Acid	29-40	neuraminidase 1	Homo sapiens	4-17
6088398-9	1984	Degradation of spleen cell sialic acid prior to periodic acid oxidation inhibited IL-2-like production by 84% and inhibited 3H-thymidine uptake by 80%.	N-Acetylneuraminic Acid	27-38	interleukin 2	Mus musculus	82-86
6740235-4	1984	These molecules may then associate by the chelation of divalent copper, via the carboxylic acid groups of the terminal sialic acid moieties of the carbohydrate side chains, to form the mucin per se.	N-Acetylneuraminic Acid	119-130	LOC100508689	Homo sapiens	185-190
6699649-3	1984	The amounts of sialic acid released by neuraminidase from intact RBC, on the other hand, did not differ significantly between the MS group and the control group.	N-Acetylneuraminic Acid	15-26	neuraminidase 1	Homo sapiens	39-52
6544896-2	1984	Although total sialic acid content was similar in both cell lines, neuraminidase-released sialic acid was twice as high in metastatic cells than that of primary cells.	N-Acetylneuraminic Acid	90-101	neuraminidase 1	Homo sapiens	67-80
6201571-5	1984	Neuraminidase treatment of cell surface salioglycoproteins or pretreatment of chromium or manganese particles with sialic acid abrogated the adverse activity of metal particles on viral IFN induction.	N-Acetylneuraminic Acid	115-126	interferon alpha 1	Homo sapiens	186-189
6717703-4	1984	As deduced from the residual content of sialic acid of erythrocytes and of the amount of sialic acid released from fetuin, the results showed a statistically higher neuraminidase-like activity of patients" sera as compared to sera of healthy individuals.	N-Acetylneuraminic Acid	89-100	neuraminidase 1	Homo sapiens	165-178
6740235-5	1984	The modulation of the mucin structure at midcycle may then be achieved by the reduction of the copper bound to the sialic acid, by the oxidation of L-ascorbic acid: the L-ascorbic acid becoming oxidized to dehydroascorbic acid.	N-Acetylneuraminic Acid	115-126	LOC100508689	Homo sapiens	22-27
6205512-4	1984	Papainization of erythrocytes enhanced markedly the susceptibility of the corresponding antigen not only to antibody binding but also to the action of neuraminidase, indicating that sialic acid is the immunodominant component of the cryptic antigen.	N-Acetylneuraminic Acid	182-193	neuraminidase 1	Homo sapiens	151-164
6740235-6	1984	This will result in an increase in hydration of the mucin by the association of water molecules with the uncomplexed sialic acid molecules of the glycoproteins.	N-Acetylneuraminic Acid	117-128	LOC100508689	Homo sapiens	52-57
6200133-4	1983	These results suggest that the primary requirement for entry of P. falciparum merozoites into human red cells is the recognition of a carbohydrate structure present on glycophorin A or B which includes sialic acid and galactose, but is not necessarily clustered at the N-terminal end of the molecule.	N-Acetylneuraminic Acid	202-213	glycophorin A (MNS blood group)	Homo sapiens	168-181
6317691-11	1983	These studies suggest that the apparent differences in molecular weight between the precursor and mature forms of the LDL receptor are largely, if not entirely, due to the addition of sialic acid and galactose residues to the O-linked GalNAc residues.	N-Acetylneuraminic Acid	184-195	low density lipoprotein receptor	Homo sapiens	118-130
6320726-4	1983	These data indicate that ACE in the circulation contains a greater amount of sialic acid than purified ACE.	N-Acetylneuraminic Acid	77-88	angiotensin I converting enzyme	Homo sapiens	25-28
6320726-5	1983	The implication is that purified ACE isoenzymes which differ in sialic acid content may not reflect tissue-specific isoenzymes but rather artifacts of purification.	N-Acetylneuraminic Acid	64-75	angiotensin I converting enzyme	Homo sapiens	33-36
6415085-1	1983	T4-binding globulin (TBG) consists of a single polypeptide chain containing 4 oligosaccharide units with an average of 10 terminal sialic acid residues.	N-Acetylneuraminic Acid	131-142	serpin family A member 7	Homo sapiens	0-19
6198439-13	1983	and with more acidic isoelectric points among them were lost by treatment with neuraminidase, suggesting that the processing was, at least in part, due to the addition of sialic acid to the precursor forms.	N-Acetylneuraminic Acid	171-182	neuraminidase 1	Homo sapiens	79-92
6415085-1	1983	T4-binding globulin (TBG) consists of a single polypeptide chain containing 4 oligosaccharide units with an average of 10 terminal sialic acid residues.	N-Acetylneuraminic Acid	131-142	serpin family A member 7	Homo sapiens	21-24
6643456-8	1983	The latter two are newly identified compounds and DG-4 contains a sugar sequence that has not been described previously, sialic acid residues linked to different hydroxyl groups of the same galactose.	N-Acetylneuraminic Acid	121-132	desmoglein 3	Homo sapiens	50-54
6197636-6	1983	Treatment of red cells with neuraminidase, which removes N-acetylneuraminic acid from glycophorin A, abolishes the binding of these three antibodies.	N-Acetylneuraminic Acid	57-80	neuraminidase 1	Homo sapiens	28-41
6197636-6	1983	Treatment of red cells with neuraminidase, which removes N-acetylneuraminic acid from glycophorin A, abolishes the binding of these three antibodies.	N-Acetylneuraminic Acid	57-80	glycophorin A (MNS blood group)	Homo sapiens	86-99
6645793-6	1983	A considerable decrease in the sialic acid content of the isolated smooth endoplasmic reticulum (one half of control values) was detected at 72 h after CCl4 administration.	N-Acetylneuraminic Acid	31-42	C-C motif chemokine ligand 4	Rattus norvegicus	152-156
6639963-2	1983	This method, which utilizes high performance liquid chromatography, distinguishes addition of sialic acid to the N-acetylgalactosamine vs. galactose residues of the mucin disaccharide Gal beta(1 leads to 3)GalNac, and can be used to distinguish formation of the 3"- and 6"-isomers of sialyllactose.	N-Acetylneuraminic Acid	94-105	mucin 1, cell surface associated	Bos taurus	165-170
6639963-3	1983	For the bovine, ovine, and porcine submaxillary extracts, more than 95% of the activity with asialo ovine submaxillary mucin is due to formation of NeuAc alpha(2 leads to 6)GalNAc.	N-Acetylneuraminic Acid	148-153	mucin 1, cell surface associated	Bos taurus	119-124
6617097-2	1983	PSS erythrocytes showed lower electrophoretic velocity and about 23% less neuraminidase-removable sialic acid density on their surface than the normal erythrocytes.	N-Acetylneuraminic Acid	98-109	neuraminidase 1	Homo sapiens	74-87
6615729-4	1983	Sialoglycoprotein alpha isolated from CDA II erythrocytes contained 30% less sialic acid than normal alpha.	N-Acetylneuraminic Acid	77-88	glycophorin A (MNS blood group)	Homo sapiens	0-23
6630194-4	1983	On the other hand, the presence of O-substituent groups renders the sialic acid molecule partially or completely resistant to the action of the currently known neuraminidase.	N-Acetylneuraminic Acid	68-79	neuraminidase 1	Homo sapiens	160-173
6619126-5	1983	Thus, the smallest variant structure was deduced to be NeuAc(alpha 2,3)Gal(beta 1,3)[GlcNAc(beta 1,6)]H2GalNAc.	N-Acetylneuraminic Acid	55-60	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	75-83
6619126-5	1983	Thus, the smallest variant structure was deduced to be NeuAc(alpha 2,3)Gal(beta 1,3)[GlcNAc(beta 1,6)]H2GalNAc.	N-Acetylneuraminic Acid	55-60	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	92-100
6619126-7	1983	Two such structures, NeuAc(alpha 2,3)Gal(beta 1,3)[GlcNAc(beta 1,?)	N-Acetylneuraminic Acid	21-26	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	27-49
6626653-4	1983	Mucin released into the culture medium contained sialic acid and hexosamine in a molar ratio of approximately 0.5-0.8:1.0.	N-Acetylneuraminic Acid	49-60	LOC100508689	Homo sapiens	0-5
6615729-4	1983	Sialoglycoprotein alpha isolated from CDA II erythrocytes contained 30% less sialic acid than normal alpha.	N-Acetylneuraminic Acid	77-88	SEC23 homolog B, COPII coat complex component	Homo sapiens	38-44
6355547-8	1983	Plasma active renin free from sialic acid is very similar to kidney renin.	N-Acetylneuraminic Acid	30-41	renin	Homo sapiens	14-19
6615438-2	1983	After administration of [3H]sphingosine-labelled GM1 all major liver gangliosides [GM3, GM2, GM1, GD1a-(NeuAc,NeuGl)] became radioactive, the radioactivity residing in all cases on the sphingosine moiety.	N-Acetylneuraminic Acid	104-109	coenzyme Q10A	Mus musculus	49-52
6577452-6	1983	The rates of aggregation of reconstituted N-CAM vesicles and native brain vesicles were found to be inversely related to the sialic acid content of their N-CAM molecules, with full desialylation resulting in about a 4-fold increase in rate over E-form N-CAM.	N-Acetylneuraminic Acid	125-136	neural cell adhesion molecule 1	Homo sapiens	42-47
6577452-6	1983	The rates of aggregation of reconstituted N-CAM vesicles and native brain vesicles were found to be inversely related to the sialic acid content of their N-CAM molecules, with full desialylation resulting in about a 4-fold increase in rate over E-form N-CAM.	N-Acetylneuraminic Acid	125-136	neural cell adhesion molecule 1	Homo sapiens	154-159
6577452-6	1983	The rates of aggregation of reconstituted N-CAM vesicles and native brain vesicles were found to be inversely related to the sialic acid content of their N-CAM molecules, with full desialylation resulting in about a 4-fold increase in rate over E-form N-CAM.	N-Acetylneuraminic Acid	125-136	neural cell adhesion molecule 1	Homo sapiens	154-159
6311200-1	1983	Homologous species specificity is demonstrated with bovine and human thyroglobulin in which the two terminal sugars of the B carbohydrate chain, sialic acid and galactose have been removed by enzymatic hydrolysis.	N-Acetylneuraminic Acid	145-156	thyroglobulin	Homo sapiens	69-82
6615438-3	1983	The specific radioactivity was highest in GM1, which carried about 53% of the radioactivity incorporated into gangliosides, followed by GM2, with 34.5% of incorporated radioactivity, GM3 and GD1a-(NeuAc,NeuGl), both with about 5% of incorporated radioactivity.	N-Acetylneuraminic Acid	197-202	coenzyme Q10A	Mus musculus	42-45
6615438-4	1983	After administration of [3H]galactose-labelled GM1 the only radioactive gangliosides present in the liver were GM1 and GD1a-(NeuAc,NeuGl), the former carrying about 95% of the total ganglioside-incorporated radioactivity, the latter about 3%.	N-Acetylneuraminic Acid	125-130	coenzyme Q10A	Mus musculus	47-50
6615438-6	1983	According to these results exogenously administered GM1, after being taken up by the liver, is mainly degraded to GM2 and GM3, a part being, however, sialylated to GD1a-(NeuAc,NeuGl).	N-Acetylneuraminic Acid	170-175	coenzyme Q10A	Mus musculus	52-55
6862694-6	1983	Compared with the NKS parental K562 tumor cells, the NKR butyrate-induced cells had 3.6- to 4.0-fold higher sialo-transferase activities and were associated with significantly greater amounts of cell surface sialic acid detected both in sialyl glycoproteins (2.2- to 2.9-fold higher) and particularly within ganglioside extracts (6.2- to 13.6-fold higher).	N-Acetylneuraminic Acid	208-219	killer cell lectin like receptor B1	Homo sapiens	53-56
6862694-7	1983	In conformity with the marked neuraminidase enhancement of NK-mediated cytolysis of the butyrate-induced targets, these NKR cells were associated with significantly enhanced levels of neuraminidase-accessible sialic acid compared to the NKS parental K562 cell line.	N-Acetylneuraminic Acid	209-220	killer cell lectin like receptor B1	Homo sapiens	120-123
6862694-7	1983	In conformity with the marked neuraminidase enhancement of NK-mediated cytolysis of the butyrate-induced targets, these NKR cells were associated with significantly enhanced levels of neuraminidase-accessible sialic acid compared to the NKS parental K562 cell line.	N-Acetylneuraminic Acid	209-220	neuraminidase 1	Homo sapiens	184-197
6871252-6	1983	In contrast, similar exposure to Ac4-NAcMan produced a large increase in the amount of radioactivity in ethanol-soluble N-acetylneuraminic acid while decreasing the amount of label from N-[3H]acetylmannosamine in cellular CMP-NeuNAc, suggesting that the analogs differ in their biochemical sites of action.	N-Acetylneuraminic Acid	120-143	immunoglobulin kappa variable 4-63	Mus musculus	33-36
6192143-6	1983	Each mucin species was found to have a distinctive hexose, hexosamine, sialic acid, and sulfate content as well as blood group substance activities.	N-Acetylneuraminic Acid	71-82	LOC100508689	Homo sapiens	5-10
6870934-9	1983	Amino acid analyses showed the two kininogen fractions to be rich in acidic amino acids and to have a total carbohydrate content of 8.5% consisting of galactose (1.2 to 1.5%), mannose (1.9 to 2.1%), N-acetylglucosamine (4.3 to 5.1%), N-acetylgalactosamine (0.3%), and sialic acid (0.68%).	N-Acetylneuraminic Acid	268-279	kininogen 2-like 1	Rattus norvegicus	35-44
6575678-0	1983	The plasma fibrinogen fraction with elevated sialic acid content and elongated gamma chains.	N-Acetylneuraminic Acid	45-56	fibrinogen beta chain	Homo sapiens	11-21
6191040-2	1983	The precursor pgF was sensitive to endoglycosidase H digestion, indicating the presence of high mannose-type oligosaccharides, whereas the stable gF product was sensitive to neuraminidase digestion, indicating the presence of sialic acid residues.	N-Acetylneuraminic Acid	226-237	placental growth factor	Homo sapiens	14-17
6882086-3	1983	It is suggested that localization of sialic acid close to that reported for neuraminidase in sperm might be of importance in the fertilization process.	N-Acetylneuraminic Acid	37-48	neuraminidase 1	Homo sapiens	76-89
6681773-2	1983	The negative surface charge density and the density of electrophoretically detectable sialic acid residues were determined to be twice as great for TA3-L as TA3-Ha cells.	N-Acetylneuraminic Acid	86-97	RIKEN cDNA 2700049A03 gene	Mus musculus	148-151
6302211-6	1983	It was already known that neuraminidase treatment of erythrocytes or glycophorin prevents interaction with either virus, suggesting that sialic acid may form part of the active binding site in the receptor.	N-Acetylneuraminic Acid	137-148	neuraminidase 1	Homo sapiens	26-39
6344077-0	1983	Molecular topography of the neural cell adhesion molecule N-CAM: surface orientation and location of sialic acid-rich and binding regions.	N-Acetylneuraminic Acid	101-112	neural cell adhesion molecule 1	Homo sapiens	28-63
6344077-6	1983	N-CAM appears to be oriented with the amino terminus extending away from the cell surface and with the bulk of the sialic acid near the middle of the peptide chain.	N-Acetylneuraminic Acid	115-126	neural cell adhesion molecule 1	Homo sapiens	0-5
6344077-7	1983	As shown previously, incubation of N-CAM at 37 degrees C generates a fragment (Fr1) of Mr 65,000 that lacks most of the sialic acid.	N-Acetylneuraminic Acid	120-131	neural cell adhesion molecule 1	Homo sapiens	35-40
6344077-8	1983	Treatment of membranes with Staphylococcus aureus V-8 protease released a fragment (Fr2) of N-CAM that contained most of the sialic acid; this fragment had an Mr of 108,000 after neuraminidase treatment.	N-Acetylneuraminic Acid	125-136	neural cell adhesion molecule 1	Homo sapiens	92-97
6344077-11	1983	Most or all of the sialic acid was not directly involved in binding, although it can influence binding, as indicated by the finding that neuraminidase-treated N-CAM (desialylated-N-CAM) bound to cells to a greater extent than untreated N-CAM.	N-Acetylneuraminic Acid	19-30	neuraminidase 1	Homo sapiens	137-150
6344077-11	1983	Most or all of the sialic acid was not directly involved in binding, although it can influence binding, as indicated by the finding that neuraminidase-treated N-CAM (desialylated-N-CAM) bound to cells to a greater extent than untreated N-CAM.	N-Acetylneuraminic Acid	19-30	neural cell adhesion molecule 1	Homo sapiens	159-164
6344077-11	1983	Most or all of the sialic acid was not directly involved in binding, although it can influence binding, as indicated by the finding that neuraminidase-treated N-CAM (desialylated-N-CAM) bound to cells to a greater extent than untreated N-CAM.	N-Acetylneuraminic Acid	19-30	neural cell adhesion molecule 1	Homo sapiens	166-184
6344077-11	1983	Most or all of the sialic acid was not directly involved in binding, although it can influence binding, as indicated by the finding that neuraminidase-treated N-CAM (desialylated-N-CAM) bound to cells to a greater extent than untreated N-CAM.	N-Acetylneuraminic Acid	19-30	neural cell adhesion molecule 1	Homo sapiens	179-184
6405810-6	1983	These data suggest that rat hemopexin contains, among others, a diantennary structure bearing three sialic acid residues.	N-Acetylneuraminic Acid	100-111	hemopexin	Rattus norvegicus	28-37
6887562-0	1983	[Changes of the blood sialic acid content in various neoplasms, with special reference to the correlation to IAP and alkaline phosphatase].	N-Acetylneuraminic Acid	22-33	alkaline phosphatase, intestinal	Homo sapiens	109-112
6311045-1	1983	A fluorometric procedure for quantitating the amount of N-acetylneuraminic acid enzymatically released by the neuraminidase activity from N-acetylneuraminyl-lactose (sialyl-lactose) has been developed.	N-Acetylneuraminic Acid	56-79	neuraminidase 1	Homo sapiens	110-123
6311045-8	1983	Reciprocally, this method can also be employed for determining the sialic acid concentration in acylneuraminyl-lactose-containing compounds when using purified neuraminidase for hydrolysis.	N-Acetylneuraminic Acid	67-78	neuraminidase 1	Homo sapiens	160-173
6189553-16	1983	In vitro degradation implying cleavage of sialic acid residues, but probably also proteolysis and/or cleavage of different glycans converted the neonatal form of BSP-2 into the triplet pattern and ultimately into a p120 component.	N-Acetylneuraminic Acid	42-53	integrin binding sialoprotein	Mus musculus	162-167
6131921-10	1983	The charge, previously shown to be dependent on the sialic acid content, was shifted to more acidic forms for lymph node Thy-1 compared to thymocytes.	N-Acetylneuraminic Acid	52-63	thymus cell antigen 1, theta	Mus musculus	121-126
6681773-2	1983	The negative surface charge density and the density of electrophoretically detectable sialic acid residues were determined to be twice as great for TA3-L as TA3-Ha cells.	N-Acetylneuraminic Acid	86-97	RIKEN cDNA 2700049A03 gene	Mus musculus	157-160
6303311-1	1983	The enzymes UDP-N-acetylglucosamine pyrophosphorylase, UDP-N-acetylglucosamine 2-epimerase, N-acetylmannosamine kinase, N-acetylglucosamine kinase and N-acetylglucosamine 2-epimerase, which are involved in the metabolism of N-acetylneuraminic acid, were studied in rat with regard to their subcellular localization and tissue distribution.	N-Acetylneuraminic Acid	224-247	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	55-118
6831485-3	1983	Gd3+ binds to the tetrasaccharide (both in the isolated, reduced form and when still attached to the native glycoprotein), and, especially, to the alpha-NeuAc residues.	N-Acetylneuraminic Acid	153-158	GRDX	Homo sapiens	0-3
6419991-1	1983	The treatment of human polymorphonuclear cells by neuraminidase "type-X" removes about 15% of cell sialic acid without modifications of NADPH oxidase activity of granulocytes before and after stimulation by opsonized zymosan.	N-Acetylneuraminic Acid	99-110	neuraminidase 1	Homo sapiens	50-63
6135409-1	1983	The secretion of mucin was assessed by measuring changes in protein and sialic acid concentrations in saliva.	N-Acetylneuraminic Acid	72-83	mucin	Canis lupus familiaris	17-22
6409502-7	1983	The kappa-casein-like component of cynomolgus monkey was highly glycosylated (about 50% carbohydrate) similarly as human kappa-casein and the constituent carbohydrates were same as those detected in human kappa-casein (galactose, fucose, N-acetylgalactosamine, N-acetylglucosamine, and sialic acid).	N-Acetylneuraminic Acid	286-297	casein kappa	Homo sapiens	4-16
6640962-6	1983	The twin bands of Ao-2 in IEF which have the same amount of sialic acid, can be separated on ConA Sepharose CL-6B, indicating that different types of oligosaccharide chains are attached to Ao-2.	N-Acetylneuraminic Acid	60-71	angiotensinogen	Rattus norvegicus	18-20
6315502-1	1983	The sialic acid residues of human alpha 1-protease inhibitor were modified by periodate oxidation and subsequent reductive amination with ethanolamine and sodium cyanoborohydride.	N-Acetylneuraminic Acid	4-15	serpin family A member 1	Homo sapiens	34-60
6201638-6	1983	Ca2+ inhibitors, La3+ and verapamil, and calmodulin inhibitors, trifluoperazine, prenylamine, and W-7, significantly inhibited the release of amylase and sialic acid induced by the stimulants.	N-Acetylneuraminic Acid	154-165	calmodulin-2	Canis lupus familiaris	41-51
6833882-6	1983	We have determined that apoA-IV is a glycoprotein containing 6% carbohydrate by weight (mannose 1.8%, galactose 1.55%, N-acetyl glucosamine 1.55%, sialic acid 1.1%).	N-Acetylneuraminic Acid	147-158	apolipoprotein A4	Homo sapiens	24-31
6653865-3	1983	We suggest that PEPCK plays a role in nuclear synthesis of N-acetyl-neuraminic acid.	N-Acetylneuraminic Acid	59-83	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	16-21
6982931-4	1982	Neuraminidase treatment of immune precipitates confirmed that Ip was a form of the I chain containing up to eight sialic acid residues.	N-Acetylneuraminic Acid	114-125	neuraminidase 1	Homo sapiens	0-13
6129975-10	1982	Thymocyte OX 2 contained higher levels of galactose and sialic acid but less fucose than brain OX 2.	N-Acetylneuraminic Acid	56-67	OX-2 membrane glycoprotein	Oryctolagus cuniculus	10-14
6835865-3	1983	Treatment with neuraminidase under conditions shown to cause complete removal of sialic acid does not abolish the observed heterogeneity.	N-Acetylneuraminic Acid	81-92	neuraminidase 1	Homo sapiens	15-28
6836584-1	1983	The present study describes the effect of fluoride (10 mg NaF/kg body weight/day) on the total protein-bound sialic acid and ceruloplasmin levels in rabbit serum after receiving sodium fluoride intragastrically for 3, 5, 8 and 10 months.	N-Acetylneuraminic Acid	109-120	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
6816288-5	1982	These physicochemical differences can be accounted for by the difference in carbohydrate content: A-1, when compared to A-2, had a higher content of sialic acid (5.0 and 2.1 mol/mol), neutral hexoses (10.2 and 5.9 mol/mol) and aminohexoses (10.5 and 7.0 mol/mol, respectively).	N-Acetylneuraminic Acid	149-160	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	98-101
6816288-5	1982	These physicochemical differences can be accounted for by the difference in carbohydrate content: A-1, when compared to A-2, had a higher content of sialic acid (5.0 and 2.1 mol/mol), neutral hexoses (10.2 and 5.9 mol/mol) and aminohexoses (10.5 and 7.0 mol/mol, respectively).	N-Acetylneuraminic Acid	149-160	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	120-123
7147211-2	1982	The removal, with time, of sialic acid residues from human fibrinogen by neuraminidase, can be explained, as a result of a mathematical analysis, by the summation of two first order reactions with clearly different rate constants.	N-Acetylneuraminic Acid	27-38	fibrinogen beta chain	Homo sapiens	59-69
7150617-3	1982	The addition of purified human plasma apolipoprotein A-I, A-II, E, C-I or C-III2 (containing 2 mol of sialic acid) to HDL2 caused inhibition of hepatic lipase activity.	N-Acetylneuraminic Acid	102-113	apolipoprotein A1	Homo sapiens	38-56
7150617-3	1982	The addition of purified human plasma apolipoprotein A-I, A-II, E, C-I or C-III2 (containing 2 mol of sialic acid) to HDL2 caused inhibition of hepatic lipase activity.	N-Acetylneuraminic Acid	102-113	NLR family pyrin domain containing 3	Homo sapiens	58-70
7150617-3	1982	The addition of purified human plasma apolipoprotein A-I, A-II, E, C-I or C-III2 (containing 2 mol of sialic acid) to HDL2 caused inhibition of hepatic lipase activity.	N-Acetylneuraminic Acid	102-113	lipase C, hepatic type	Homo sapiens	144-158
6960362-1	1982	The neural cell adhesion molecule (N-CAM) has an unusually high amount of sialic acid (28-35 g/100 g of polypeptide) and shows microheterogeneity in electrophoretic gels in its embryonic or E form.	N-Acetylneuraminic Acid	74-85	neural cell adhesion molecule 1	Mus musculus	4-33
6960362-1	1982	The neural cell adhesion molecule (N-CAM) has an unusually high amount of sialic acid (28-35 g/100 g of polypeptide) and shows microheterogeneity in electrophoretic gels in its embryonic or E form.	N-Acetylneuraminic Acid	74-85	neural cell adhesion molecule 1	Mus musculus	35-40
7118917-6	1982	One source of heterogeneity contributing to both isoelectric focusing profiles is variation in sialic acid content, since neuraminidase treatment of the link protein preparations produces a shift to subcomponents with more basic pI.	N-Acetylneuraminic Acid	95-106	neuraminidase 1	Homo sapiens	122-135
6959126-2	1982	This antigen was identified as human N-CAM according to several criteria, including molecular weight, sialic acid content, amino acid composition, analysis of peptide fragments, reactivity with a variety of anti-CAM antibodies, and activity of the antigen in assays of cell and membrane vesicle aggregation.	N-Acetylneuraminic Acid	102-113	neural cell adhesion molecule 1	Homo sapiens	37-42
7144883-0	1982	Surface sialic acid reduces attachment of metastatic tumour cells to collagen type IV and fibronectin.	N-Acetylneuraminic Acid	8-19	fibronectin 1	Homo sapiens	69-101
7159403-4	1982	Binding of peanut agglutinin and to a lesser extent of Ricinus communis agglutinin I were found to be dependent on prior removal of sialic acid residues from the glycoproteins.	N-Acetylneuraminic Acid	132-143	agglutinin	Ricinus communis	72-84
6816283-3	1982	Forms B and C contained sialic acid which could be removed by neuraminidase digestion.	N-Acetylneuraminic Acid	24-35	neuraminidase 1	Homo sapiens	62-75
7130178-4	1982	The CMP-sialic acid:nLcOse4Cer (alpha 2-3)sialyltransferase activity sediments (90%) at the junction of 1.2 M and 1.5 M on a discontinuous sucrose density gradient when still membrane bound (insoluble in 0.2% Triton X-100).	N-Acetylneuraminic Acid	8-19	ST3 beta-galactoside alpha-2,3-sialyltransferase 6	Gallus gallus	32-59
7107565-1	1982	The effectiveness of 13 N-acetylneuraminic acid derivatives as potential inducers of Arthrobacter sialophilus neuraminidase were examined.	N-Acetylneuraminic Acid	24-47	neuraminidase 1	Homo sapiens	110-123
7107565-3	1982	The C-4 hydroxyl function of N-acetylneuraminic acid was essential for enzyme derepression.	N-Acetylneuraminic Acid	29-52	complement C4A (Rodgers blood group)	Homo sapiens	4-7
7147211-2	1982	The removal, with time, of sialic acid residues from human fibrinogen by neuraminidase, can be explained, as a result of a mathematical analysis, by the summation of two first order reactions with clearly different rate constants.	N-Acetylneuraminic Acid	27-38	neuraminidase 1	Homo sapiens	73-86
6814359-6	1982	These results suggest that the terminal N-acetylneuraminic acid (NANA) residues of gangliosides and of glycophorin play an important role in the inhibition of IFN-beta, and that they may be similarly involved in the inhibition of IFN-gamma.	N-Acetylneuraminic Acid	40-63	interferon beta 1	Homo sapiens	159-167
7147211-3	1982	Quantitative studies on the bound sialic acid to isolated fibrinogen chains, after reduction and alkylation of the partially desialylated fibrinogen, show that the fast reaction takes place with the sialic acid bound to the B beta chains.	N-Acetylneuraminic Acid	34-45	fibrinogen beta chain	Homo sapiens	58-68
7147211-3	1982	Quantitative studies on the bound sialic acid to isolated fibrinogen chains, after reduction and alkylation of the partially desialylated fibrinogen, show that the fast reaction takes place with the sialic acid bound to the B beta chains.	N-Acetylneuraminic Acid	34-45	fibrinogen beta chain	Homo sapiens	138-148
7147211-3	1982	Quantitative studies on the bound sialic acid to isolated fibrinogen chains, after reduction and alkylation of the partially desialylated fibrinogen, show that the fast reaction takes place with the sialic acid bound to the B beta chains.	N-Acetylneuraminic Acid	199-210	fibrinogen beta chain	Homo sapiens	58-68
7147211-3	1982	Quantitative studies on the bound sialic acid to isolated fibrinogen chains, after reduction and alkylation of the partially desialylated fibrinogen, show that the fast reaction takes place with the sialic acid bound to the B beta chains.	N-Acetylneuraminic Acid	199-210	fibrinogen beta chain	Homo sapiens	138-148
7147211-5	1982	Coagulation with thrombin of desialylated fibrinogen shows that the aggregation rate increases linearly as the amount of sialic acid residues decreases, regardless of their location in the fibrinogen molecule.	N-Acetylneuraminic Acid	121-132	fibrinogen beta chain	Homo sapiens	42-52
7104389-7	1982	Neuraminidase decreased the reduced viscosity of soluble phase mucin by 50% by removing about 30% of its N-acetylneuraminic acid but had no effect on fibrillar and gelatinous mucins.	N-Acetylneuraminic Acid	105-128	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	63-68
7117239-4	1982	The following extensions to Gal-6" are proposed: NeuAc(alpha 2-6) (glycopeptide A), Gal(beta 1-3) (glycopeptide D) and Fuc(alpha 1-6) (glycopeptide E).	N-Acetylneuraminic Acid	49-54	immunoglobulin binding protein 1	Homo sapiens	55-64
7085639-8	1982	Upon treatment of the mucin with neuraminidase, loss of inhibitory activity was observed which was proportional to the loss of sialic acid from the mucin.	N-Acetylneuraminic Acid	127-138	mucin 1, cell surface associated	Bos taurus	22-27
7085639-8	1982	Upon treatment of the mucin with neuraminidase, loss of inhibitory activity was observed which was proportional to the loss of sialic acid from the mucin.	N-Acetylneuraminic Acid	127-138	mucin 1, cell surface associated	Bos taurus	148-153
7085646-3	1982	The carbohydrate composition of N-CAM includes 13 mol of sialic acid but only 1.4 mol of galactose/100 mol of amino acids, suggesting the presence of a sialic acid to protein linkage not previously observed in higher organisms.	N-Acetylneuraminic Acid	57-68	neural cell adhesion molecule 1	Gallus gallus	32-37
7085646-3	1982	The carbohydrate composition of N-CAM includes 13 mol of sialic acid but only 1.4 mol of galactose/100 mol of amino acids, suggesting the presence of a sialic acid to protein linkage not previously observed in higher organisms.	N-Acetylneuraminic Acid	152-163	neural cell adhesion molecule 1	Gallus gallus	32-37
7085646-9	1982	On prolonged incubation at neutral pH, N-CAM undergoes apparent proteolysis to yield a polypeptide that contains little sialic acid and has a Mr = 65,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, a separate sialic acid-rich component, and a variety of small peptides.	N-Acetylneuraminic Acid	120-131	neural cell adhesion molecule 1	Gallus gallus	39-44
7085646-9	1982	On prolonged incubation at neutral pH, N-CAM undergoes apparent proteolysis to yield a polypeptide that contains little sialic acid and has a Mr = 65,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis, a separate sialic acid-rich component, and a variety of small peptides.	N-Acetylneuraminic Acid	227-238	neural cell adhesion molecule 1	Gallus gallus	39-44
6180496-6	1982	Neuraminidase removal of platelet surface sialic acid resulted in dose-dependent decreases of EPM which paralleled decreases in sialic acid.	N-Acetylneuraminic Acid	42-53	neuraminidase 1	Homo sapiens	0-13
7121828-1	1982	We have studied the topography of the gangliosides of the adrenal chromaffin granules by using neuraminidase to remove sialic acid from membrane gangliosides of intact and ruptured chromaffin granules.	N-Acetylneuraminic Acid	119-130	neuraminidase 1	Bos taurus	95-108
7121828-4	1982	Prolonged digestion of broken membranes showed that maximally 75% of both lipid and protein-bound sialic acid residues are available to neuraminidase.	N-Acetylneuraminic Acid	98-109	neuraminidase 1	Bos taurus	136-149
6180496-6	1982	Neuraminidase removal of platelet surface sialic acid resulted in dose-dependent decreases of EPM which paralleled decreases in sialic acid.	N-Acetylneuraminic Acid	128-139	neuraminidase 1	Homo sapiens	0-13
7092339-4	1982	Changes in serum total sialic acid levels paralleled those in CRP and SAA in RA as well as in SLE.	N-Acetylneuraminic Acid	23-34	C-reactive protein	Homo sapiens	62-65
7092339-4	1982	Changes in serum total sialic acid levels paralleled those in CRP and SAA in RA as well as in SLE.	N-Acetylneuraminic Acid	23-34	serum amyloid A1	Homo sapiens	70-73
6805533-7	1982	The smaller multimers of the fVIII/vWf protein have a reduced sialic acid and PAS-Coomassie staining ratio.	N-Acetylneuraminic Acid	62-73	coagulation factor VIII	Homo sapiens	29-34
6805533-7	1982	The smaller multimers of the fVIII/vWf protein have a reduced sialic acid and PAS-Coomassie staining ratio.	N-Acetylneuraminic Acid	62-73	von Willebrand factor	Homo sapiens	35-38
6813002-1	1982	Cultured skin fibroblasts from patients with mucolipidosis IV were found to be deficient in neuraminidase activity toward GD1a and GD1b gangliosides radiolabelled in C8 and C7 analogs of their sialic acid residues.	N-Acetylneuraminic Acid	193-204	neuraminidase 1	Homo sapiens	92-105
7095839-2	1982	We reported previously that an anti-p cold agglutinin was inhibited by sialosyllactoneotetraosylceramide, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc-Cer, the most abundant ganglioside of human erythrocytes.	N-Acetylneuraminic Acid	106-111	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	126-132
6981512-1	1982	Unfractionated normal blood lymphocytes (predominantly T lymphocytes) showed significantly elevated total and neuraminidase-susceptible sialic acid compared with CLL lymphocytes (predominantly B lymphocytes).	N-Acetylneuraminic Acid	136-147	neuraminidase 1	Bos taurus	110-123
7068676-6	1982	N-Acetylneuraminic acid, but not its methyl ester, was a competitive inhibitor of neuraminidase.	N-Acetylneuraminic Acid	0-23	neuraminidase 1	Homo sapiens	82-95
7095839-2	1982	We reported previously that an anti-p cold agglutinin was inhibited by sialosyllactoneotetraosylceramide, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc-Cer, the most abundant ganglioside of human erythrocytes.	N-Acetylneuraminic Acid	106-111	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	142-150
7095839-2	1982	We reported previously that an anti-p cold agglutinin was inhibited by sialosyllactoneotetraosylceramide, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc-Cer, the most abundant ganglioside of human erythrocytes.	N-Acetylneuraminic Acid	106-111	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	142-148
7095839-4	1982	These two gangliosides have the same carbohydrate chain, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc(SNH), but they differ in their ceramide moiety.	N-Acetylneuraminic Acid	57-62	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	77-83
6949986-4	1982	Nonequilibrium pH gradient electrophoresis excluded the possibility that any of the species was invariant chain, but rather suggested that the subspecies were structurally related and that alpha 3 has fewer sialic acid residues than alpha 1 and alpha 2.	N-Acetylneuraminic Acid	207-218	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	189-196
6949986-5	1982	Sialic acid differences between alpha 1, alpha 2, and alpha 3 were further suggested by SDS-PAGE and by peptide mapping of neuraminidase-treated immunoprecipitates.	N-Acetylneuraminic Acid	0-11	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	32-61
7182951-7	1982	This shifting was mostly reversible when apoE was treated with neuraminidase, suggesting that cholesterol feeding leads to a modification of apoE by increasing its content of sialic acid.	N-Acetylneuraminic Acid	175-186	apolipoprotein E	Cavia porcellus	41-45
7095839-4	1982	These two gangliosides have the same carbohydrate chain, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc(SNH), but they differ in their ceramide moiety.	N-Acetylneuraminic Acid	57-62	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	93-101
7182951-7	1982	This shifting was mostly reversible when apoE was treated with neuraminidase, suggesting that cholesterol feeding leads to a modification of apoE by increasing its content of sialic acid.	N-Acetylneuraminic Acid	175-186	apolipoprotein E	Cavia porcellus	141-145
7095839-4	1982	These two gangliosides have the same carbohydrate chain, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc(SNH), but they differ in their ceramide moiety.	N-Acetylneuraminic Acid	57-62	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	93-99
7095839-4	1982	These two gangliosides have the same carbohydrate chain, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc(SNH), but they differ in their ceramide moiety.	N-Acetylneuraminic Acid	57-62	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	93-99
6920385-3	1982	Chicken antithrombin is a single-chain glycoprotein with a total carbohydrate content of 17.5%, including 6.0% N-acetylglucosamine, 8.7% hexose, and 2.8% N-acetylneuraminic acid.	N-Acetylneuraminic Acid	154-177	serpin family C member 1	Gallus gallus	8-20
6210469-1	1982	GM2 ganglioside labelled with tritium in the N-acetylneuraminic acid moiety was prepared and used to measure beta-hexosaminidase A activity in cultured humans skin fibroblasts extracts.	N-Acetylneuraminic Acid	45-68	O-GlcNAcase	Homo sapiens	109-128
7106500-2	1982	On the other hand, BSP binding capacity of receptors was hardly destroyed by digestion with high concentration of phospholipase A, C. Gel filtration experiments on a column of Sephadex indicated that specific BSP binding to a protein in the high-speed supernatant was observed and this protein contained at least sialic acid and pentose suggesting a fragment of glycoprotein.	N-Acetylneuraminic Acid	313-324	phospholipase A and acyltransferase 1	Rattus norvegicus	114-129
7071802-0	1982	Sialic acid dependent polypeptide chain heterogeneity of human fibrinogen demonstrated by two-dimensional electrophoresis.	N-Acetylneuraminic Acid	0-11	fibrinogen beta chain	Homo sapiens	63-73
6282672-7	1982	These results suggest that the GnRH-receptor of rat pituitary is a glycoprotein which contains sialic acid residue and that GnRH agonists and antagonists bind differently to the same receptor.	N-Acetylneuraminic Acid	95-106	gonadotropin releasing hormone receptor	Rattus norvegicus	31-44
6282672-7	1982	These results suggest that the GnRH-receptor of rat pituitary is a glycoprotein which contains sialic acid residue and that GnRH agonists and antagonists bind differently to the same receptor.	N-Acetylneuraminic Acid	95-106	gonadotropin releasing hormone 1	Rattus norvegicus	31-35
7051949-3	1982	On activating surfaces of the alternative pathway, C3b, Bb is relatively resistant to regulation by H. In contrast, non-activating surfaces exhibit surface characteristics such as high content in membrane-associated sialic acid or heparin-related material which increase the interaction of H with cell-bound C3b.	N-Acetylneuraminic Acid	216-227	complement C3	Homo sapiens	51-54
7076644-3	1982	Sialic acid of GM4 was exclusively N-acetylneuraminic acid, while GM2 contained only N-glycolylneuraminic acid.	N-Acetylneuraminic Acid	0-11	T cell receptor alpha variable 6-3	Mus musculus	15-18
7076644-3	1982	Sialic acid of GM4 was exclusively N-acetylneuraminic acid, while GM2 contained only N-glycolylneuraminic acid.	N-Acetylneuraminic Acid	35-58	T cell receptor alpha variable 6-3	Mus musculus	15-18
7076644-6	1982	One is the pathway to GM4 (NeuAc) from galactosylceramide, and the other is that for synthesizing GM2 (NeuGc) from glucosylceramide.	N-Acetylneuraminic Acid	27-32	T cell receptor alpha variable 6-3	Mus musculus	22-25
7110505-1	1982	Incubation of primary nerve cell cultures and of crude synaptosomal preparations with neuraminidase released sialic acid from both gangliosides and sialoglycoproteins.	N-Acetylneuraminic Acid	109-120	neuraminidase 1	Homo sapiens	86-99
7076853-5	1982	Limited incubation of the abnormal lipoproteins with neuraminidase caused a partial loss of sialic acid and resulted in a triglyceride-rich lipoprotein with a normal C-III-2:C-III-1 ratio.	N-Acetylneuraminic Acid	92-103	neuraminidase 1	Homo sapiens	53-66
6800417-4	1982	Comparison of the purified normal and vWd f.VIIi/vWf protein revealed several abnormalities, including decreased concentration of f.VIII/vWf antigen; decreased specific vWf activity; absence of the larger molecular forms of the f.VIII/vWf protein; carbohydrate deficiencies affecting the sialic acid, penultimate galactose and N-acetylglucosamine moieties; and decreased binding of the f.VIII/vWf protein to its platelet receptor.	N-Acetylneuraminic Acid	288-299	von Willebrand factor	Homo sapiens	49-52
6800417-6	1982	f.VIII/vWf protein to normal f.VIII/vWf protein that had been treated with 2-mercaptoethanol (2-ME) to reduce the multimer size and then treated with specific exoglycosidases to remove the sialic acid and penultimate galactose residues revealed similar biologic properties.	N-Acetylneuraminic Acid	189-200	von Willebrand factor	Homo sapiens	7-10
7071802-6	1982	It is concluded that enzymatic removal of sialic acid partially reduced the heterogeneity of the gamma- and B beta-polypeptide chains of human fibrinogen, but additional sources producing charge heterogeneity must be sought.	N-Acetylneuraminic Acid	42-53	fibrinogen beta chain	Homo sapiens	143-153
7056710-0	1982	A subfraction of human fibrinogen with high sialic acid content and elongated gamma chains.	N-Acetylneuraminic Acid	44-55	fibrinogen beta chain	Homo sapiens	23-33
6122564-5	1982	Following incubation with neuraminidase, however, the isoelectric point of F-11 became similar to that of F-I, suggesting that this difference in electrophoretic mobility is due to a difference in the content of sialic acid moiety.	N-Acetylneuraminic Acid	212-223	neuraminidase 1	Homo sapiens	26-39
7056710-3	1982	The most acidic fraction comprising 22% of the whole fibrinogen pool was prominent by two special features: 1) its sialic acid content was significantly higher than that of bulk fibrinogen, namely 8 mol of sialic acid/mol of fibrinogen versus 6 mol in bulk fibrinogen.	N-Acetylneuraminic Acid	115-126	fibrinogen beta chain	Homo sapiens	53-63
6459381-5	1982	The acquired resistance of the cell-bound, P-stabilized amplification convertase to decay-dissociation by beta-1H was directly related to the activating capacity of the treated cells in whole serum (r = 0.95) and to the amount of sialic acid removed from the cells by the virus (r = 0.98).	N-Acetylneuraminic Acid	230-241	complement factor H	Homo sapiens	106-113
6957642-9	1982	Sensitive tumor cells with high cell surface sialic acid, after neuraminidase treatment, became resistant to the effects of cytotoxic macrophages and the effect of the neuraminidase treatment was blocked by addition of sialic acid to the incubation mixture.	N-Acetylneuraminic Acid	45-56	neuraminidase 1	Homo sapiens	64-77
6957642-9	1982	Sensitive tumor cells with high cell surface sialic acid, after neuraminidase treatment, became resistant to the effects of cytotoxic macrophages and the effect of the neuraminidase treatment was blocked by addition of sialic acid to the incubation mixture.	N-Acetylneuraminic Acid	45-56	neuraminidase 1	Homo sapiens	168-181
6957642-9	1982	Sensitive tumor cells with high cell surface sialic acid, after neuraminidase treatment, became resistant to the effects of cytotoxic macrophages and the effect of the neuraminidase treatment was blocked by addition of sialic acid to the incubation mixture.	N-Acetylneuraminic Acid	219-230	neuraminidase 1	Homo sapiens	64-77
6957642-9	1982	Sensitive tumor cells with high cell surface sialic acid, after neuraminidase treatment, became resistant to the effects of cytotoxic macrophages and the effect of the neuraminidase treatment was blocked by addition of sialic acid to the incubation mixture.	N-Acetylneuraminic Acid	219-230	neuraminidase 1	Homo sapiens	168-181
7172413-3	1982	Neuraminidase treatments caused a time- and dose-related release of sialic acid from the cells and enhanced the stimulatory effect of cholera toxin on basal and TPA-induced ODC activities as much as the monosialoganglioside GM1.	N-Acetylneuraminic Acid	68-79	neuraminidase 1	Homo sapiens	0-13
6290353-0	1982	Fibrinogen-bound sialic acid levels in the dysfibrinogenaemia of liver disease.	N-Acetylneuraminic Acid	17-28	fibrinogen beta chain	Homo sapiens	0-10
6290353-1	1982	Fibrinogen-bound sialic acid levels were determined in 75 normal controls and 80 patients with liver disease.	N-Acetylneuraminic Acid	17-28	fibrinogen beta chain	Homo sapiens	0-10
6290353-3	1982	Enzymatic removal of sialic acid from the abnormal fibrinogens corrected the abnormal FMP and thrombin-clotting times to the range of desialated controls.	N-Acetylneuraminic Acid	21-32	coagulation factor II, thrombin	Homo sapiens	94-102
7056855-4	1982	Extensive charge heterogeneity in the 45,000-dalton heavy chain was detected when B27 molecules were analyzed by two-dimensional gel electrophoresis; the charge heterogeneity was reduced, but not eliminated, when the B27 molecules were treated with neuraminidase to remove sialic acid residues before analysis.	N-Acetylneuraminic Acid	273-284	melanocortin 2 receptor accessory protein	Homo sapiens	217-220
7056855-4	1982	Extensive charge heterogeneity in the 45,000-dalton heavy chain was detected when B27 molecules were analyzed by two-dimensional gel electrophoresis; the charge heterogeneity was reduced, but not eliminated, when the B27 molecules were treated with neuraminidase to remove sialic acid residues before analysis.	N-Acetylneuraminic Acid	273-284	neuraminidase 1	Homo sapiens	249-262
7159292-10	1982	The minimizing of this effect by the addition of neuraminidase suggests that this attachment may be through sialic acid residues.	N-Acetylneuraminic Acid	108-119	neuraminidase 1	Bos taurus	49-62
7129234-1	1982	Fibrinogen-bound sialic acid was determined in a large series of normal adult, full-term pre-term cord blood samples.	N-Acetylneuraminic Acid	17-28	fibrinogen beta chain	Homo sapiens	0-10
7129234-2	1982	Sialic acid was significantly higher in the full-term cord fibrinogen than controls, and higher in premature than term samples.	N-Acetylneuraminic Acid	0-11	fibrinogen beta chain	Homo sapiens	59-69
7129234-4	1982	There was significant correlation between sialic acid content and thrombin time in full-term cord samples.	N-Acetylneuraminic Acid	42-53	coagulation factor II, thrombin	Homo sapiens	66-74
7129234-5	1982	It is concluded that fetal fibrinogen is characterised by an elevated sialic acid content, and that the degree of hypersialation is a function of gestational age.	N-Acetylneuraminic Acid	70-81	fibrinogen beta chain	Homo sapiens	27-37
7089371-6	1982	It is postulated that the early anaemia observed in infected animals may be attributable to the activities of the circulating trypanosomes which produce neuraminidase which, in turn, cleaves off surface sialic acid, thus rendering the erythrocyte more prone to phagocytosis by the recticuloendothelial system.	N-Acetylneuraminic Acid	203-214	neuraminidase 1	Bos taurus	153-166
6184338-11	1982	Concurrent assays for sialic acid recovered from the tumor cells indicated that lectin bound surface sialic acid was removable with neuraminidase.	N-Acetylneuraminic Acid	22-33	neuraminidase 1	Homo sapiens	132-145
6184338-11	1982	Concurrent assays for sialic acid recovered from the tumor cells indicated that lectin bound surface sialic acid was removable with neuraminidase.	N-Acetylneuraminic Acid	101-112	neuraminidase 1	Homo sapiens	132-145
7326264-4	1981	We have called this protein rat serum amyloid P-component since it has all the properties typical of human serum amyloid P-component: it is made up to 10 subunits, it contains sialic acid and hexoses, it forms macroscopic polymers and its does not precipitate with pneumococcal C-polysaccharide.	N-Acetylneuraminic Acid	176-187	amyloid P component, serum	Rattus norvegicus	32-57
7309731-7	1981	The sialic acid profile on Bio-Gel P-10 chromatography, following alkaline borohydride degradation, showed the presence of both keratan sulfate and oligosaccharide chains.	N-Acetylneuraminic Acid	4-15	S100 calcium binding protein A10	Homo sapiens	35-39
7326264-4	1981	We have called this protein rat serum amyloid P-component since it has all the properties typical of human serum amyloid P-component: it is made up to 10 subunits, it contains sialic acid and hexoses, it forms macroscopic polymers and its does not precipitate with pneumococcal C-polysaccharide.	N-Acetylneuraminic Acid	176-187	amyloid P component, serum	Rattus norvegicus	107-132
7296000-8	1981	However, the two fractions of prothrombin differ in their content of neutral sugar and of sialic acid residues.	N-Acetylneuraminic Acid	90-101	coagulation factor II, thrombin	Homo sapiens	30-41
6174385-7	1981	Both in cirrhosis and cancers, ACT levels were not correlated with any of serum bilirubin and serum enzyme activities, but were positively correlated with the levels of plasma fibrinogen and serum sialic acid.	N-Acetylneuraminic Acid	197-208	serpin family A member 3	Homo sapiens	31-34
6279816-2	1981	Unmasking of T-antigens results from removal of N-acetyl-neuraminic acid by neuraminidase, an enzyme commonly produced by a variety of bacteria.	N-Acetylneuraminic Acid	48-72	neuraminidase 1	Homo sapiens	76-89
7296000-9	1981	Removal of sialic acid with neuraminidase abolishes the electrophoretic heterogeneity.	N-Acetylneuraminic Acid	11-22	neuraminidase 1	Homo sapiens	28-41
7296000-10	1981	Thus, the charge heterogneity of the three variants of prothrombin found in normal human plasma appears to result exclusively from differences in the number of sialic acid residues attached to the protein moiety of the molecule.	N-Acetylneuraminic Acid	160-171	coagulation factor II, thrombin	Homo sapiens	55-66
7309293-4	1981	While no correlation could be made between the NK-sensitivity of these variants and their total cellular sialic acid, a statistically significant inverse correlation was observed between the levels of percentage neuraminidase releasable surface sialic acid of total labelled sialyl components and sensitivity to NK cells.	N-Acetylneuraminic Acid	245-256	neuraminidase 1	Homo sapiens	212-225
6270119-5	1981	Isopycnic rubidium chloride gradient centrifugation, a procedure used in the isolation of thyroglobulin molecules with a low iodine content, also isolates thyroglobulin molecules with a low sialic acid content and with an increased ability to interact with wheat germ agglutinin, a lectin which recognizes exposed N-acetylglucosamine residues.	N-Acetylneuraminic Acid	190-201	thyroglobulin	Bos taurus	155-168
7030111-0	1981	Evidence of a reduced sialic acid content in serum transferrin in male alcoholics.	N-Acetylneuraminic Acid	22-33	transferrin	Homo sapiens	51-62
6797758-4	1981	Determination of glycoprotein samples treated with neuraminidase for varying periods of time revealed an increasing underestimation by the EID method with decreasing sialic acid content.	N-Acetylneuraminic Acid	166-177	neuraminidase 1	Bos taurus	51-64
7295796-2	1981	Yolk RBP was found to contain 5--6 mannose, five galactose, 12 N-acetylglucosamine and four sialic acid residues.	N-Acetylneuraminic Acid	92-103	riboflavin binding protein	Gallus gallus	5-8
7295796-9	1981	Removal of sialic acid decreased the half-life of yolk RBP by 31%, while the other modifications decreased the half-life by as much as 60%.	N-Acetylneuraminic Acid	11-22	riboflavin binding protein	Gallus gallus	55-58
7030111-2	1981	Certain indirect evidence has supported the assumption that the basis for the altered transferrin heterogeneity would be a reduced sialic acid content.	N-Acetylneuraminic Acid	131-142	transferrin	Homo sapiens	86-97
7030111-4	1981	The sialic acid content in transferrin was thereafter determined directly.	N-Acetylneuraminic Acid	4-15	transferrin	Homo sapiens	27-38
7030111-5	1981	Transferrin from alcoholic patients showed a 22% lower sialic acid concentration than control transferrin, which was highly significant.	N-Acetylneuraminic Acid	55-66	transferrin	Homo sapiens	0-11
7030111-6	1981	These data together with results from experiments with neuraminidase and galactose-binding lectin provide evidence that in alcoholism at least two sialic acid residues are missing in a significant fraction of serum transferrin.	N-Acetylneuraminic Acid	147-158	transferrin	Homo sapiens	215-226
7030111-7	1981	This observation may indicate that sialic acid residues are missing in a significant fraction of serum transferrin.	N-Acetylneuraminic Acid	35-46	transferrin	Homo sapiens	103-114
6975776-7	1981	However, both CSF-tm and CSF-dGlc seemed to have retained sialic acid residues, because they were focused respectively at pH 4.2 and pH 3.7 upon isoelectric focusing, and both were converted to a pH 5.2 species by treatment with neuraminidase.	N-Acetylneuraminic Acid	58-69	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	14-17
7338387-0	1981	Free sialic acid in CSF in the differential diagnosis of meningitis.	N-Acetylneuraminic Acid	5-16	colony stimulating factor 2	Homo sapiens	20-23
7309693-4	1981	Removal of the majority of exposed sialic acid residues from the membrane outer surface by neuraminidase treatment had no influence on the cell shape, or on the pH-dependence of the shape change.	N-Acetylneuraminic Acid	35-46	neuraminidase 1	Homo sapiens	91-104
6975776-7	1981	However, both CSF-tm and CSF-dGlc seemed to have retained sialic acid residues, because they were focused respectively at pH 4.2 and pH 3.7 upon isoelectric focusing, and both were converted to a pH 5.2 species by treatment with neuraminidase.	N-Acetylneuraminic Acid	58-69	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	25-33
6456769-4	1981	However, incorporation of sialic acid into neuraminidase-treated beta-N-acetylhexosaminidase A and B amounted to a 58 to 72% saturation of the theoretical acceptor sites, respectively.	N-Acetylneuraminic Acid	26-37	neuraminidase 1	Homo sapiens	43-56
6456769-4	1981	However, incorporation of sialic acid into neuraminidase-treated beta-N-acetylhexosaminidase A and B amounted to a 58 to 72% saturation of the theoretical acceptor sites, respectively.	N-Acetylneuraminic Acid	26-37	O-GlcNAcase	Homo sapiens	65-92
6790534-6	1981	Rat alpha-1-antitrypsin contains 14.3 residues/mol of N-acetylglucosamine, 5.0 residues/mol of mannose, 4.2 residues/mol of galactose, and 5.8 residues/mol of sialic acid.	N-Acetylneuraminic Acid	159-170	serpin family A member 1	Homo sapiens	4-23
6168285-5	1981	The activity of viral neuraminidase is also temperature dependent, and it increases with increase of the incubation temperature; release of N-acetylneuraminic acid was negligible at 0 degrees C. Shift-up of the incubation temperature immediately cancelled HVJ-induced agglutination of liposomes.	N-Acetylneuraminic Acid	140-163	neuraminidase 1	Homo sapiens	22-35
7320438-6	1981	The significant difference was that while sialic acid was undetectable in hCG-choriocarcinoma approximately 8.5% of sialic acid was found in hCG-normal pregnancy and hCG-hydatidiform mole.	N-Acetylneuraminic Acid	116-127	chorionic gonadotropin subunit beta 5	Homo sapiens	141-144
6166674-12	1981	Cell-surface labeling of sialic acid residues and neuraminidase digestion showed that p97 is a sialoglycoprotein.	N-Acetylneuraminic Acid	25-36	melanotransferrin	Homo sapiens	86-89
7320438-6	1981	The significant difference was that while sialic acid was undetectable in hCG-choriocarcinoma approximately 8.5% of sialic acid was found in hCG-normal pregnancy and hCG-hydatidiform mole.	N-Acetylneuraminic Acid	116-127	chorionic gonadotropin subunit beta 5	Homo sapiens	141-144
6787052-7	1981	Mucin A (pronase digest fraction 1 from molecular sieve chromatography) was enriched in threonine, proline, and sialic acid, while mucin B (pronase digest fraction 3 from molecular sieve chromatography) was enriched in serine, alanine, and fucose.	N-Acetylneuraminic Acid	112-123	LOC100508689	Homo sapiens	0-5
6782114-6	1981	The N-acetylneuraminic acid (NANA) content of the four TBG bands isolated by preparative IEF was found to decrease from 10.2 mol NANA/mol TBG in the band at pH 4.25 to 4.8 mol NANA/mol TBG in the band at pH 4.55.	N-Acetylneuraminic Acid	4-27	serpin family A member 7	Homo sapiens	55-58
7195813-9	1981	The terminal sialic acid moieties of major glycoproteins (IbA1, IbB1 and IIIbA1) were more intensely labelled in Glanzmann"s thrombasthenia than in normals and these glycoproteins had an altered pI.	N-Acetylneuraminic Acid	13-24	allograft inflammatory factor 1	Homo sapiens	58-62
7215299-3	1981	Removal of sialic acid residues resulted in a reduction of the half-life of rat transcortin from 4 h to 90 sec.	N-Acetylneuraminic Acid	11-22	serpin family A member 6	Rattus norvegicus	80-91
7215299-8	1981	When injected into hamsters, rat and human transcortin both had relatively long half-lives (5.8 and 6.8 h, respectively), which were dramatically shortened when sialic acid was removed.	N-Acetylneuraminic Acid	161-172	serpin family A member 6	Homo sapiens	43-54
7243384-2	1981	The use of desialylated preparations of purified human plasma alpha 2-macroglobulin, as an acceptor, demonstrated 35 to 52% reduction in the incorporation of sialic acid into the alpha 2-macroglobulin from patients with cystic fibrosis as compared to that of alpha 2-macroglobulin from normal controls.	N-Acetylneuraminic Acid	158-169	alpha-2-macroglobulin	Homo sapiens	62-83
7243384-2	1981	The use of desialylated preparations of purified human plasma alpha 2-macroglobulin, as an acceptor, demonstrated 35 to 52% reduction in the incorporation of sialic acid into the alpha 2-macroglobulin from patients with cystic fibrosis as compared to that of alpha 2-macroglobulin from normal controls.	N-Acetylneuraminic Acid	158-169	alpha-2-macroglobulin	Homo sapiens	179-200
7243384-2	1981	The use of desialylated preparations of purified human plasma alpha 2-macroglobulin, as an acceptor, demonstrated 35 to 52% reduction in the incorporation of sialic acid into the alpha 2-macroglobulin from patients with cystic fibrosis as compared to that of alpha 2-macroglobulin from normal controls.	N-Acetylneuraminic Acid	158-169	alpha-2-macroglobulin	Homo sapiens	179-200
6786888-13	1981	The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn.	N-Acetylneuraminic Acid	55-60	galanin and GMAP prepropeptide	Homo sapiens	61-115
6786888-13	1981	The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn.	N-Acetylneuraminic Acid	55-60	adrenoceptor alpha 1D	Homo sapiens	131-138
6786888-13	1981	The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn.	N-Acetylneuraminic Acid	55-60	galanin and GMAP prepropeptide	Homo sapiens	157-211
6786888-13	1981	The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn.	N-Acetylneuraminic Acid	55-60	adrenoceptor alpha 1D	Homo sapiens	227-234
6786888-13	1981	The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn.	N-Acetylneuraminic Acid	55-60	adrenoceptor alpha 1D	Homo sapiens	227-234
6786888-13	1981	The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn.	N-Acetylneuraminic Acid	151-156	galanin and GMAP prepropeptide	Homo sapiens	61-115
6786888-13	1981	The structure of the N-glycosidically-linked chain was NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 6)[NeuAc(alpha 2 leads to 6)Gal(beta 1 leads to 4)GlcNAc(beta 1 leads to 2)Man(alpha 1 leads to 3)]Man(beta 1 leads to 4)GlcNAc(beta 1 leads to 4)[Fuc alpha 1 leads to 6]GlcNAc leads to Asn.	N-Acetylneuraminic Acid	151-156	adrenoceptor alpha 1D	Homo sapiens	131-138
6786888-14	1981	The second O-glycosidically-linked chain was a disialylated tetrasaccharide with the structure, Neu(alpha 2 leads to 3)Gal(beta 1 leads to 3)[NeuAc(alpha 2 leads to 6)GalNAc leads to Ser.	N-Acetylneuraminic Acid	142-147	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	96-99
7231488-1	1981	It has been suggested that in acute poststreptococcal glomerulonephritis, streptococcal neuraminidase may remove sialic acid from some normal plasma or tissue components, thus rendering it antigenic.	N-Acetylneuraminic Acid	113-124	neuraminidase 1	Homo sapiens	88-101
6788858-4	1981	Although the sialic acid content of colonized patients" cells was less than that of controls" cells, removal of sialic acid from normal cells with neuraminidase did not increase bacillary adherence.	N-Acetylneuraminic Acid	112-123	neuraminidase 1	Homo sapiens	147-160
6165502-6	1981	The present data suggest that the novel gamma-glutamyl transpeptidase has the same antigen site as the normal kidney enzyme, but differs from the latter at least in its sialic acid content and in some other carbohydrate moieties.	N-Acetylneuraminic Acid	169-180	inactive glutathione hydrolase 2	Homo sapiens	40-69
7316970-4	1981	glycoprotein, were detected only after treating the myelin membrane with neuraminidase, N-acetylneuraminic acid is a terminal sugar residue in these glycoproteins.	N-Acetylneuraminic Acid	88-111	neuraminidase 1	Homo sapiens	73-86
6782114-6	1981	The N-acetylneuraminic acid (NANA) content of the four TBG bands isolated by preparative IEF was found to decrease from 10.2 mol NANA/mol TBG in the band at pH 4.25 to 4.8 mol NANA/mol TBG in the band at pH 4.55.	N-Acetylneuraminic Acid	4-27	serpin family A member 7	Homo sapiens	138-141
6782114-6	1981	The N-acetylneuraminic acid (NANA) content of the four TBG bands isolated by preparative IEF was found to decrease from 10.2 mol NANA/mol TBG in the band at pH 4.25 to 4.8 mol NANA/mol TBG in the band at pH 4.55.	N-Acetylneuraminic Acid	4-27	serpin family A member 7	Homo sapiens	138-141
6780555-9	1981	Neuraminidase degradation studies demonstrated that only one ganglioside species of each cell type contains an internally linked sialic acid residue, and on the basis of thin layer chromatographic analysis this component is the same as the major brain ganglioside, GM1 (II3-N-acetylneuraminosyl-gangliotetraosylceramide).	N-Acetylneuraminic Acid	129-140	neuraminidase 1	Homo sapiens	0-13
7247048-3	1981	The acrosomal membrane fraction (Mf 1) contains about 10% carbohydrates which are composed of fucose, mannose, galactose, N-acetylglucosamine, N-acetylgalactosamine and N-acetylneuraminic acid in the molar ratio 1:3:6:4.5:2:3.	N-Acetylneuraminic Acid	169-192	flap structure-specific endonuclease 1	Homo sapiens	33-37
7216166-4	1981	It appeared that [14C]-sialic acid had been introduced exclusively to the galactose residues of Gal beta(1 leads to 3)GalNAc disaccharide units occurring on the mucin as minor chains.	N-Acetylneuraminic Acid	23-34	LOC100508689	Homo sapiens	161-166
7216166-7	1981	When the asialo-mucin had been [14C]sialylated by an ovine submaxillary gland cell-free preparation analysis of the product oligosaccharide chain revealed the introduction of [14C]sialic acid to position C-6 on the GalNAc residues.	N-Acetylneuraminic Acid	180-191	LOC100508689	Homo sapiens	16-21
7216169-7	1981	Starch gel electrophoresis and neuraminidase-specific staining with NeuAc alpha 2 leads to (3-methoxyphenyl) glycoside revealed two major and three minor enzyme bands.	N-Acetylneuraminic Acid	68-73	neuraminidase 1	Homo sapiens	31-44
7216169-9	1981	Among the different groups of naturally occurring NeuAc-containing substrates, i.e. glycoproteins, gangliosides and oligosaccharides, B. lactentis neuraminidase cleaves oligosaccharides preferentially without remarkable differences between (alpha 2 leads to 3) and (alpha 2 leads to 6) linkages.	N-Acetylneuraminic Acid	50-55	neuraminidase 1	Homo sapiens	147-160
6267177-8	1981	Pulse-chase experiments and treatment of infected cells with neuraminidase suggested that glycoproteins gB, gC and gD contain sialic acid and that synthesis of gB and gD occurs by at least 15 and 10 discrete steps respectively.	N-Acetylneuraminic Acid	126-137	neuraminidase 1	Homo sapiens	61-74
7305927-4	1981	The amniotic-fluid fibronectins had similar mannose and sialic acid contents to plasma fibronectin, but greater amounts of glucosamine, galactosamine, galactose and fucose.	N-Acetylneuraminic Acid	56-67	fibronectin 1	Homo sapiens	19-30
7460824-6	1981	Thus, sialic acid alone and/or differences in subunit assembly seem to be responsible for the electrophoretic heterogeneity of highly purified hCG.	N-Acetylneuraminic Acid	6-17	hypertrichosis 2 (generalised, congenital)	Homo sapiens	143-146
6792056-2	1981	When the surface charge of HRC was reduced by treating them with neuraminidase (to remove some negative sialic acid residues) or coating them with polylysine (a positively charged polymer), no substantial binding to macrophages was obtained.	N-Acetylneuraminic Acid	104-115	histidine rich calcium binding protein	Homo sapiens	27-30
7451969-0	1981	The role of sialic acid in the functional activity and the hepatic clearance of C1-INH.	N-Acetylneuraminic Acid	12-23	serpin family G member 1	Homo sapiens	80-86
7024999-6	1981	Neuraminidase removal of the sialic acid component of the glomerular glycocalyx and exposure to either cytochalasin B (25 microgram/ml) or cytochalasin D (2 microgram/ml), prevent the in vitro formation of podocyte microprojections.	N-Acetylneuraminic Acid	29-40	neuraminidase 1	Homo sapiens	0-13
7451969-4	1981	In vivo studies in the rabbit, however, showed that removal of sialic acid residues resulted in rapid blood clearance of C1-INH and enhanced localization of the asialo C1-INH in the liver.	N-Acetylneuraminic Acid	63-74	plasma protease C1 inhibitor	Oryctolagus cuniculus	121-127
7451969-4	1981	In vivo studies in the rabbit, however, showed that removal of sialic acid residues resulted in rapid blood clearance of C1-INH and enhanced localization of the asialo C1-INH in the liver.	N-Acetylneuraminic Acid	63-74	plasma protease C1 inhibitor	Oryctolagus cuniculus	168-174
7471482-2	1980	The reaction includes neuraminidase hydrolysis of glycoprotein, cleavage of sialic acid to pyruvate by N-acetyl neuraminic acid (NANA)-aldolase, oxidation of pyruvate by pyruvate oxidase which produces hydrogen peroxide, and colorimetry of hydrogen peroxide using the peroxidase-p-chlorophenol-4-amino-antipyrine method.	N-Acetylneuraminic Acid	76-87	N-acetylneuraminate pyruvate lyase	Homo sapiens	103-143
6253668-11	1980	Neuraminidase treatment decreased the size, number, and acidic charge of the spots, suggesting that processing was due in part, but not entirely, to addition of sialic acid to pgD and pgC.	N-Acetylneuraminic Acid	161-172	neuraminidase 1	Homo sapiens	0-13
6449508-9	1980	Preliminary evidence has been obtained indicating that sialic acid linked alpha 2-6 to GalNAc or L-fucose linked alpha 1-2 to Gal inhibit the action of the beta 6-N-acetylglucosaminyltransferase on Gal beta 1-3GalNAc-porcine submaxillary mucin polypeptide.	N-Acetylneuraminic Acid	55-66	mucin	Canis lupus familiaris	238-243
7213638-4	1980	However, prior treatment with neuraminidase results in a single form of RNAase C with an isoelectric point of 10.4, indicating that the charge heterogeneity is the result of variability in sialic acid content.	N-Acetylneuraminic Acid	189-200	neuraminidase 1	Homo sapiens	30-43
6253668-11	1980	Neuraminidase treatment decreased the size, number, and acidic charge of the spots, suggesting that processing was due in part, but not entirely, to addition of sialic acid to pgD and pgC.	N-Acetylneuraminic Acid	161-172	phosphoglycerate dehydrogenase	Homo sapiens	176-179
6253668-11	1980	Neuraminidase treatment decreased the size, number, and acidic charge of the spots, suggesting that processing was due in part, but not entirely, to addition of sialic acid to pgD and pgC.	N-Acetylneuraminic Acid	161-172	progastricsin	Homo sapiens	184-187
6161246-1	1980	The possible function of sialic acid containing substrates in the synaptic terminals was studied by intracellular injection of ruthenium red (RuR) and neuraminidase (NAA).	N-Acetylneuraminic Acid	25-36	neuraminidase 1	Homo sapiens	151-164
6255042-1	1980	A sensitive assay was developed for the measurement of neuraminidase with use of the 4-methylumbelliferkyl-alph-ketoside of N-acetyl-neuraminic acid as a fluorescent substrate.	N-Acetylneuraminic Acid	124-148	neuraminidase 1	Homo sapiens	55-68
7426100-3	1980	The treatment with neuraminidase from Clostridium perfringens removed 90% of the sialic acid residues which did not change the chemical composition of the lipoproteins.	N-Acetylneuraminic Acid	81-92	neuraminidase 1	Homo sapiens	19-32
6161246-1	1980	The possible function of sialic acid containing substrates in the synaptic terminals was studied by intracellular injection of ruthenium red (RuR) and neuraminidase (NAA).	N-Acetylneuraminic Acid	25-36	neuraminidase 1	Homo sapiens	166-169
7380837-3	1980	alpha-Lactalbumin isolated from the Wistar rat exists as two forms which differ in their sialic acid content, as the desialyated forms migrate to one identical position on polyacrylamide gels.	N-Acetylneuraminic Acid	89-100	lactalbumin, alpha	Rattus norvegicus	0-17
7388951-4	1980	Sialic acid removal through neuraminidase treatment reduced the electrophoretic mobility of both forms rendering them identical in migration without, however, altering the activity.	N-Acetylneuraminic Acid	0-11	neuraminidase 1	Homo sapiens	28-41
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	N-Acetylneuraminic Acid	40-45	galanin and GMAP prepropeptide	Bos taurus	65-68
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	N-Acetylneuraminic Acid	40-45	galanin and GMAP prepropeptide	Bos taurus	88-91
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	N-Acetylneuraminic Acid	40-45	galanin and GMAP prepropeptide	Bos taurus	88-91
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	N-Acetylneuraminic Acid	126-131	galanin and GMAP prepropeptide	Bos taurus	65-68
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	N-Acetylneuraminic Acid	126-131	galanin and GMAP prepropeptide	Bos taurus	88-91
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	N-Acetylneuraminic Acid	126-131	galanin and GMAP prepropeptide	Bos taurus	88-91
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	N-Acetylneuraminic Acid	126-131	galanin and GMAP prepropeptide	Bos taurus	65-68
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	N-Acetylneuraminic Acid	126-131	galanin and GMAP prepropeptide	Bos taurus	88-91
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	N-Acetylneuraminic Acid	126-131	galanin and GMAP prepropeptide	Bos taurus	88-91
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	N-Acetylneuraminic Acid	126-131	galanin and GMAP prepropeptide	Bos taurus	65-68
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	N-Acetylneuraminic Acid	126-131	galanin and GMAP prepropeptide	Bos taurus	88-91
7397215-1	1980	360-MHz 1H-NMR spectra were recorded of NeuAc alpha(2 leads to 3)Gal beta (1 leads to 3)GalNAc-ol (I), Gal beta(1 leads to 3)[NeuAc alpha(2 leads to 6)] GalNAc-ol (II) and NeuAc alpha (2 leads to 3)-Gal beta(1 leads to 3) [NeuAc alpha(2 leads to 6)]GalNAc-ol (III).	N-Acetylneuraminic Acid	126-131	galanin and GMAP prepropeptide	Bos taurus	88-91
6966283-11	1980	The sialic acid of human alpha 1-protease inhibitor was determined to be N-acetylneuraminic acid.	N-Acetylneuraminic Acid	4-15	serpin family A member 1	Homo sapiens	25-51
6966283-11	1980	The sialic acid of human alpha 1-protease inhibitor was determined to be N-acetylneuraminic acid.	N-Acetylneuraminic Acid	73-96	serpin family A member 1	Homo sapiens	25-51
7371855-0	1980	Sialic acid residues inhibit proteolytic degradation of dopamine beta-hydroxylase.	N-Acetylneuraminic Acid	0-11	dopamine beta-hydroxylase	Homo sapiens	56-81
6251424-10	1980	It seems most likely that neuraminidase cleaves sialic-acid-containing-compounds associated with the nerve terminal surface membrane, probably thus causing failure of transmitter release.	N-Acetylneuraminic Acid	48-59	neuraminidase 1	Homo sapiens	26-39
6988512-0	1980	Role of sialic acid in the macrophage glycolipid receptor for MIF.	N-Acetylneuraminic Acid	8-19	macrophage migration inhibitory factor	Cavia porcellus	62-65
6104657-9	1980	A linear relationship was found between the isoelectric points of the enzymes and their contents of sialic acid, indicating that the heterogeneity of papain-solubilized gamma-glutamyltranspeptidase is mostly due to differences in the extends of sialylation of the enzymes.	N-Acetylneuraminic Acid	100-111	gamma-glutamyltransferase 1	Rattus norvegicus	169-197
6988512-4	1980	In order to investigate whether sialic acid is essential for the macrophage"s response to MIF, macrophages were incubated with neuraminidase.	N-Acetylneuraminic Acid	32-43	macrophage migration inhibitory factor	Cavia porcellus	90-93
6988512-8	1980	These experiments suggest that macrophage glycolipids containing sialic acid are components of the macrophage receptor for MIF.	N-Acetylneuraminic Acid	65-76	macrophage migration inhibitory factor	Cavia porcellus	123-126
6154123-7	1980	It was suggested that sialic acid residues present in the surface of BHK-R cell membranes and responsible for adsorption of HVJ were split off by the action of neuraminidase of virus particles, resulting in inhibition of the attachment of challenge virus of HVJ.	N-Acetylneuraminic Acid	22-33	neuraminidase 1	Homo sapiens	160-173
6245583-5	1980	Removal of sialic acid from hCG increased this rate; removal of other carbohydrate residues decreased it.	N-Acetylneuraminic Acid	11-22	hypertrichosis 2 (generalised, congenital)	Homo sapiens	28-31
7362830-4	1980	Antithrombin III was a glycoprotein containing 3.6% glucosamine, 0.2% fucose, 2.5% mannose, 1.6% galactose and 3.9% sialic acid.	N-Acetylneuraminic Acid	116-127	serpin family C member 1	Rattus norvegicus	0-16
7361617-0	1980	"Neuraminidase-resistant" sialic acid residues of gangliosides.	N-Acetylneuraminic Acid	26-37	neuraminidase 1	Homo sapiens	1-14
6965519-0	1980	T-lymphocyte differentiation is accompanied by increase in sialic acid content of Thy-1 antigen.	N-Acetylneuraminic Acid	59-70	Thy-1 cell surface antigen	Homo sapiens	82-95
6445994-3	1980	Treatment of the fragmented SR with neuraminidase (EC 3.2.1.18; NAase) resulted in the release of sialic acid.	N-Acetylneuraminic Acid	98-109	neuraminidase 1	Homo sapiens	36-49
6243885-0	1980	The synthesis of 4-methylumbelliferyl alpha-ketoside of N-acetylneuraminic acid and its  use in a fluorometric assay for neuraminidase.	N-Acetylneuraminic Acid	56-79	neuraminidase 1	Homo sapiens	121-134
7458421-5	1980	PP15 is a glycoprotein and contains 3.3% carbohydrates (hexoses 2.8%, hexosamines 0.3%, sialic acid 0.2%).	N-Acetylneuraminic Acid	88-99	nuclear transport factor 2	Homo sapiens	0-4
508810-6	1979	The purified mucin fraction contained 16.5% protein and primarily galactose, N-acetylglucosamine, N-acetylgalactosamine, and sialic acid.	N-Acetylneuraminic Acid	125-136	solute carrier family 13 member 2	Rattus norvegicus	13-18
6787617-2	1980	The abnormality consists of a selective increase of a cathodal transferrin component which is probably caused by a reduction of the sialic acid content.	N-Acetylneuraminic Acid	132-143	transferrin	Homo sapiens	63-74
7423117-12	1980	Neuraminidase removal of the glomerular sialic acid surface coat inhibits the formation of free surface microvilli and results in an early loss of podocyte foot processes.	N-Acetylneuraminic Acid	40-51	neuraminidase 1	Homo sapiens	0-13
542928-1	1979	Addition of N-acetyl neuraminic acid (sialic acid, NANA) to citrated rat platelet-rich plasma significantly inhibited aggregation induced by near-threshold concentration of ADP, collagen or thrombin.	N-Acetylneuraminic Acid	12-36	coagulation factor II	Rattus norvegicus	190-198
41843-7	1979	It is concluded that there are exposed sialic acid groups at the lunimal cell surface which are absent or significantly fewer at the sites of the DF, whereas other anionic materials possibly with a pKa higher than that of sialic acid (pKa 2.6) are present both at the DF and at the nonmodified endothelial cell surface.	N-Acetylneuraminic Acid	222-233	protein kinase cAMP-activated catalytic subunit alpha	Sus scrofa	235-238
542928-1	1979	Addition of N-acetyl neuraminic acid (sialic acid, NANA) to citrated rat platelet-rich plasma significantly inhibited aggregation induced by near-threshold concentration of ADP, collagen or thrombin.	N-Acetylneuraminic Acid	38-49	coagulation factor II	Rattus norvegicus	190-198
43443-0	1979	Tissue difference in gamma-glutamyl transpeptidase attributed to sialic acid content.	N-Acetylneuraminic Acid	65-76	inactive glutathione hydrolase 2	Homo sapiens	21-50
91457-1	1979	Purified preparations of plasma alpha 2-macroglobulin from patients with cystic fibrosis are shown to have normal amounts of total hexose but as much as 40% decrease in their sialic acid content.	N-Acetylneuraminic Acid	175-186	alpha-2-macroglobulin	Homo sapiens	32-53
501288-9	1979	It is noteworthy that both surface constituents known to maintain a particle as a nonactivator of the alternative pathway, sialic acid and N-sulfated mucopolysaccharide, act by facilitating the inactivation by regulatory proteins of the function of particle-bound C3b.	N-Acetylneuraminic Acid	123-134	complement C3	Homo sapiens	264-267
551286-2	1979	AAG consists of a single polypeptide chain, has a molecular weight of 44,100, and contains approximately 45% carbohydrate including 12% sialic acid; it is the most negatively charged of the plasma proteins.	N-Acetylneuraminic Acid	136-147	N-methylpurine DNA glycosylase	Homo sapiens	0-3
551286-3	1979	Certain of the biological properties of AAG are related to its sialic acid content; thus, clearance and immunogenicity of AAG are markedly increased on desialisation.	N-Acetylneuraminic Acid	63-74	N-methylpurine DNA glycosylase	Homo sapiens	40-43
551286-3	1979	Certain of the biological properties of AAG are related to its sialic acid content; thus, clearance and immunogenicity of AAG are markedly increased on desialisation.	N-Acetylneuraminic Acid	63-74	N-methylpurine DNA glycosylase	Homo sapiens	122-125
482913-0	1979	[Importance of the sialic acid moiety for the heterogeneity in human fibrinogen].	N-Acetylneuraminic Acid	19-30	fibrinogen beta chain	Homo sapiens	69-79
482913-5	1979	The difference in sialic acid content of the gamma- and B beta-chain variants of human fibrinogen therefore explains on part of the polypeptide chain heterogeneity.	N-Acetylneuraminic Acid	18-29	fibrinogen beta chain	Homo sapiens	87-97
381752-6	1979	From these results the conclusion was reached that cell surface glycoproteins of melanomas are substituted with sialic acid so that their D-galactose and/or N-acetyl-D-galactosamine residues are available for oxidation by galactose oxidase only after neuraminidase treatment.	N-Acetylneuraminic Acid	112-123	neuraminidase 1	Homo sapiens	251-264
90077-5	1979	This second group of anionic compounds is neuraminidase resistant and has a pKa higher than that of sialic acid (pKa:2.6).	N-Acetylneuraminic Acid	100-111	neuraminidase 1	Homo sapiens	42-55
465537-4	1979	The chemical composition of the glycoprotein resembles glycophorin A from human erythrocyte membranes in that it has a high content of N-acetylgalactosamine, N-acetylglucosamine, galactose and sialic acid and a particularly large proportion of serine, threonine, aspartic acid and glutamic acid.	N-Acetylneuraminic Acid	193-204	glycophorin A (MNS blood group)	Homo sapiens	55-68
446474-9	1979	Cathepsin D-I contained 6.6% carbohydrate, consisting of mannose, glucose, galactose, fucose and glucosamine in a ratio of 8:2:1:1:5 with a trace of sialic acid.	N-Acetylneuraminic Acid	149-160	cathepsin D	Rattus norvegicus	0-11
221458-9	1979	The complex nature of these results is interpreted in the light of additional data which show (i) that the thyroid membrane recognizes asialothyroglobulin and (ii) that at pH 5.0 and 37 degrees C a membrane-associated neuraminidase is activated which removes sialic acid from thyroglobulin.	N-Acetylneuraminic Acid	259-270	neuraminidase 1	Homo sapiens	218-231
222332-5	1979	Apolipoprotein CIII was separated into several protein bands with pI ranging from 4.7 to 5.1 as a function of their number of sialic acid residues.	N-Acetylneuraminic Acid	126-137	apolipoprotein C3	Homo sapiens	0-19
39290-11	1979	Treating the muscles with neuraminidase diminishes the net negative charge density, and hence shifts the surface potential to more positive values, by release of negatively charged sialic acid.	N-Acetylneuraminic Acid	181-192	neuraminidase 1	Homo sapiens	26-39
100492-2	1978	Human factor VIII/von Willebrand factor protein containing 120 +/- 12 nmol of sialic acid and 135 +/- 13 nmol of galactose/mg of protein was digested with neuraminidase.	N-Acetylneuraminic Acid	78-89	neuraminidase 1	Homo sapiens	155-168
33713-2	1979	A sialyltransferase (CMP-N-acetylneuraminate:D-galactosyl-glycoprotein N-acetylneuraminyltransferase, EC 2.4.99.1) which attaches N-acetylneuraminic acid to the terminal end of the carbohydrate chain of kappa-casein was found to be concentrated in Golgi apparatus-enriched fractions of bovine mammary gland.	N-Acetylneuraminic Acid	130-153	casein kappa	Bos taurus	203-215
390986-6	1979	Sialic acid residues on C3b-bearing particles augment binding of beta 1H to favor competition with B, inactivation of C3b and decay-dissociation of C3b, Bb.	N-Acetylneuraminic Acid	0-11	complement C3	Homo sapiens	24-27
390986-6	1979	Sialic acid residues on C3b-bearing particles augment binding of beta 1H to favor competition with B, inactivation of C3b and decay-dissociation of C3b, Bb.	N-Acetylneuraminic Acid	0-11	complement factor H	Homo sapiens	65-72
390986-6	1979	Sialic acid residues on C3b-bearing particles augment binding of beta 1H to favor competition with B, inactivation of C3b and decay-dissociation of C3b, Bb.	N-Acetylneuraminic Acid	0-11	complement C3	Homo sapiens	118-121
390986-6	1979	Sialic acid residues on C3b-bearing particles augment binding of beta 1H to favor competition with B, inactivation of C3b and decay-dissociation of C3b, Bb.	N-Acetylneuraminic Acid	0-11	complement C3	Homo sapiens	118-121
99447-2	1978	The carbohydrate composition of TBG (14.6% by weight) consists of mannose, galactose, N-acetylglucosamine, and N-acetylneuraminic acid in the molar ratios of 11:9:16:10 per mol of glycoprotein.	N-Acetylneuraminic Acid	111-134	serpin family A member 7	Homo sapiens	32-35
287036-4	1979	Dog placental ALPase has the same electrophoretic mobility as dog liver, bone, and kidney ALPases after removal of sialic acid residues with neuraminidase.	N-Acetylneuraminic Acid	115-126	neuraminidase 1	Homo sapiens	141-154
437784-0	1979	Neuraminidase treatment reveals sialic acid differences in certain genetic variants of the Gc system (vitamin-D-binding protein).	N-Acetylneuraminic Acid	32-43	neuraminidase 1	Homo sapiens	0-13
433157-10	1979	Further, we observed that intracytoplasmic membranes from infected cells contain much less sialic acid than those from uninfected cells, indicating that viral neuraminidase present in the interior of infected cells possesses enzymatic activity.	N-Acetylneuraminic Acid	91-102	neuraminidase 1	Homo sapiens	159-172
116481-5	1979	There is evidence of a reduced sialic acid content in the abnormal transferrin.	N-Acetylneuraminic Acid	31-42	transferrin	Homo sapiens	67-78
91354-4	1979	These observations suggest that viral neuraminidase in the membrane is the site of attachment of the sialic acid moieties of fetuin spheres.	N-Acetylneuraminic Acid	101-112	neuraminidase 1	Homo sapiens	38-51
762425-0	1979	Human alternative complement pathway: membrane-associated sialic acid regulates the competition between B and beta1 H for cell-bound C3b.	N-Acetylneuraminic Acid	58-69	complement factor H	Homo sapiens	110-117
762425-0	1979	Human alternative complement pathway: membrane-associated sialic acid regulates the competition between B and beta1 H for cell-bound C3b.	N-Acetylneuraminic Acid	58-69	endogenous retrovirus group K member 3	Homo sapiens	133-136
29906-3	1978	Desialylation of human red blood cells (RBC) by Vibrio cholerae neuraminidase (VCN) was found to produce cells with electrophoretic properties which were inconsistent with the view of simple loss of N-acetylneuraminic acid (NANA) as the sole effect of VCN treatment.	N-Acetylneuraminic Acid	199-222	neuraminidase 1	Homo sapiens	64-77
308510-0	1978	Studies on the attachment of N-acetylneuraminic acid to glycopeptides from alpha-1-antitrypsin.	N-Acetylneuraminic Acid	29-52	serpin family A member 1	Homo sapiens	75-94
694494-1	1978	Human erythrocyte membranes contain two different triton-activated galactosyltransferase activities, one of which is specific for ovalbumin and the other for sialic acid free ovine submaxillary mucin.	N-Acetylneuraminic Acid	158-169	LOC100508689	Homo sapiens	194-199
104712-22	1978	beta-Galactosidase A2 contained 7.5% carbohydrate by weight and sialic acid, D-galactose, D-glucosamine and D-mannose were present in the molar proportions 1.1:1.0:1.7:2.7.	N-Acetylneuraminic Acid	64-75	galactosidase beta 1	Homo sapiens	0-18
714935-0	1978	Shape change and the percentage of sialic acid removed by neuraminidase from human platelets.	N-Acetylneuraminic Acid	35-46	neuraminidase 1	Homo sapiens	58-71
710425-2	1978	Galactosyltransferase A incorporated galactose from UDP-Gal into sialic-acid-free ovine submaxillary mucin (asialo-mucin), whereas galactosyltransferase B transferred galactose from UDP-Gal to free N-acetylglucosamine or N-acetylglucosamine-glycoproteins.	N-Acetylneuraminic Acid	65-76	LOC100508689	Homo sapiens	101-106
310304-1	1978	Multiple components of human alpha1-antitrypsin were separated by preparative starch gel electrophoresis, and the sialic acid contents of these components were determined.	N-Acetylneuraminic Acid	114-125	serpin family A member 1	Homo sapiens	29-47
82453-18	1978	AFP is a glycoprotein containing 7 per cent carbohydrate including 1.67 per cent hexoses, 2.38 per cent N-acetyl glucosamine and 1.8 per cent N-acetyl neuraminic acid.	N-Acetylneuraminic Acid	142-166	alpha fetoprotein	Bos taurus	0-3
687592-2	1978	The composition and molecular weight of the Pronase glycopeptides revealed that rabbit transferrin contains two heteropolysaccharide units, each composed of 2 sialic acid residues, 2 galactose residues, 3 mannose residues, and 4-N-acetylglucosamine residues.	N-Acetylneuraminic Acid	159-170	serotransferrin	Oryctolagus cuniculus	87-98
361654-1	1978	Using a modified colloidal iron reaction in connection with neuraminidase extraction test 3 different sialic acid-containing components have been demonstrated in pancreatic islets comprising golgi region and glycocalyx layer of islet cells and intrainsular capillary walls.	N-Acetylneuraminic Acid	102-113	neuraminidase 1	Homo sapiens	60-73
728843-7	1978	Incubation of human angiotensinogens with neuraminidase for 3 or 16 h raised their isoelectric pH by about 0.5 U, probably due to removal of sialic acid.	N-Acetylneuraminic Acid	141-152	neuraminidase 1	Homo sapiens	42-55
100027-2	1978	The N-acetylneuraminic acid concentration was determined from the duodenum of cat 1 and from a clinically normal cat (cat 2).	N-Acetylneuraminic Acid	4-27	GIT ArfGAP 1	Homo sapiens	78-83
207986-7	1978	Enzymatic cleavage of sialic acid from the abnormal fibrinogen restored fibrinogen function to normal.	N-Acetylneuraminic Acid	22-33	fibrinogen beta chain	Homo sapiens	52-62
668697-5	1978	The chemical shifts of the anomeric and mannose H-2 protons give information about the type of glycan structure (mono-, bi-, triantennary) and the presence of terminal sialic acid at each of the antennas.	N-Acetylneuraminic Acid	168-179	relaxin 2	Homo sapiens	48-51
207986-7	1978	Enzymatic cleavage of sialic acid from the abnormal fibrinogen restored fibrinogen function to normal.	N-Acetylneuraminic Acid	22-33	fibrinogen beta chain	Homo sapiens	72-82
307560-3	1978	Removal of greater than 95% of the sialic acid from this protein by neuraminidase did not affect the von Willebrand factor or procoagulant activity.	N-Acetylneuraminic Acid	35-46	neuraminidase 1	Homo sapiens	68-81
686677-20	1978	Treatment of the various ALPs with neuraminidase to remove sialic acid residues does not affect their inhibition characteristics or activities.	N-Acetylneuraminic Acid	59-70	neuraminidase 1	Homo sapiens	35-48
217642-1	1978	Removal of the sugar residues internal to sialic acid from the hCG molecule markedly diminished the ability of hCG to stimulate cAMP accumulation by porcine granulosa cells during a 30-min incubation period.	N-Acetylneuraminic Acid	42-53	hypertrichosis 2 (generalised, congenital)	Homo sapiens	63-66
217642-1	1978	Removal of the sugar residues internal to sialic acid from the hCG molecule markedly diminished the ability of hCG to stimulate cAMP accumulation by porcine granulosa cells during a 30-min incubation period.	N-Acetylneuraminic Acid	42-53	hypertrichosis 2 (generalised, congenital)	Homo sapiens	111-114
217642-2	1978	At the same time, removal of sugars internal to sialic acid enabled the resulting hCG derivatives to become competitive inhibitors of hCG stimulation of cAMP accumulation.	N-Acetylneuraminic Acid	48-59	hypertrichosis 2 (generalised, congenital)	Homo sapiens	82-85
217642-2	1978	At the same time, removal of sugars internal to sialic acid enabled the resulting hCG derivatives to become competitive inhibitors of hCG stimulation of cAMP accumulation.	N-Acetylneuraminic Acid	48-59	hypertrichosis 2 (generalised, congenital)	Homo sapiens	134-137
217642-4	1978	It would, therefore, seem that hCG with sugars internal to sialic acid removed is able to bind to the receptor, but that, once bound, it is unable to activate adenylate cyclase.	N-Acetylneuraminic Acid	59-70	hypertrichosis 2 (generalised, congenital)	Homo sapiens	31-34
668697-6	1978	The chemical shifts of sialic acid H-3 protons are typical for sialic acid residues in 2 leads to 3 or 2 leads to 6 linkage to galactose.	N-Acetylneuraminic Acid	23-34	H3 clustered histone 14	Homo sapiens	35-38
668697-6	1978	The chemical shifts of sialic acid H-3 protons are typical for sialic acid residues in 2 leads to 3 or 2 leads to 6 linkage to galactose.	N-Acetylneuraminic Acid	63-74	H3 clustered histone 14	Homo sapiens	35-38
656465-2	1978	About 5 per cent of the secreted proteins and 2.4 per cent of the secreted protein-bound sialic acid was recovered as the purified AM2 protein.	N-Acetylneuraminic Acid	89-100	adrenomedullin 2	Mus musculus	131-134
77312-7	1978	Transferrin of CSF included several components with lower sialic acid contents than in serum.	N-Acetylneuraminic Acid	58-69	laminin subunit gamma 2	Homo sapiens	15-18
629985-4	1978	Arthrobacter neuraminidase is a monomeric glycoprotein of molecular weight 88 000, has an apparent Km of 7.8-10(-4) M for N-acetylneuraminlactose, is insensitive to inhibition by N-acetylneuraminic acid, and is about 2% carbohydrate by weight.	N-Acetylneuraminic Acid	179-202	neuraminidase 1	Homo sapiens	13-26
304805-6	1978	The pI of the various microheterogeneous fractions are given for protein M. Stepwise desialylation of alpha1-antitrypsin indicates that the charge difference between the major fractions is one sialic acid residue between each.	N-Acetylneuraminic Acid	193-204	serpin family A member 1	Homo sapiens	102-120
623792-2	1978	The uptake of sialic acid-rich normal plasma beta-hexosaminidase was minimal and neuraminidase treatment did not appreciably enhance uptake.	N-Acetylneuraminic Acid	14-25	O-GlcNAcase	Homo sapiens	45-64
623792-3	1978	In contrast, sialic acid-rich normal seminal fluid beta-hexosaminidase was readily pinocytosed regardless of neuraminidase treatment.	N-Acetylneuraminic Acid	13-24	O-GlcNAcase	Homo sapiens	51-70
623792-4	1978	Thus the presence of sialic acid on beta-hexosaminidase does not influence uptake and a neuraminidase deficiency in I-cell disease may not be directly responsible for excessive extracellular enzyme.	N-Acetylneuraminic Acid	21-32	O-GlcNAcase	Homo sapiens	36-55
624734-0	1978	Separation of both the Bbeta- and the gamma-polypeptide chains of human fibrinogen into two main types which differ in sialic acid content.	N-Acetylneuraminic Acid	119-130	fibrinogen beta chain	Homo sapiens	72-82
624734-8	1978	A larger ratio of L/R in the gamma and Bbeta chains of dysfibrinogenemia fibrinogen "Zurich II" than in those of normal fibrinogen explains the higher content of sialic acid measured in the native Zurich II fibrinogen molecule.	N-Acetylneuraminic Acid	162-173	fibrinogen beta chain	Homo sapiens	58-68
624734-8	1978	A larger ratio of L/R in the gamma and Bbeta chains of dysfibrinogenemia fibrinogen "Zurich II" than in those of normal fibrinogen explains the higher content of sialic acid measured in the native Zurich II fibrinogen molecule.	N-Acetylneuraminic Acid	162-173	fibrinogen beta chain	Homo sapiens	73-83
624734-8	1978	A larger ratio of L/R in the gamma and Bbeta chains of dysfibrinogenemia fibrinogen "Zurich II" than in those of normal fibrinogen explains the higher content of sialic acid measured in the native Zurich II fibrinogen molecule.	N-Acetylneuraminic Acid	162-173	fibrinogen beta chain	Homo sapiens	73-83
304805-12	1978	A difference of one sialic acid residue was obtained for proteins M and Z by the thiobarbituric assay, but stepwise removal of sialic acid with neuraminidase revealed almost identical stepwise change of pattern of both proteins indicating the same number of sialic acid residues.	N-Acetylneuraminic Acid	127-138	neuraminidase 1	Homo sapiens	144-157
304805-12	1978	A difference of one sialic acid residue was obtained for proteins M and Z by the thiobarbituric assay, but stepwise removal of sialic acid with neuraminidase revealed almost identical stepwise change of pattern of both proteins indicating the same number of sialic acid residues.	N-Acetylneuraminic Acid	127-138	neuraminidase 1	Homo sapiens	144-157
621288-4	1978	A progressive delay in thrombin time was associated with increasing sialic acid content of the patient fibrinogen.	N-Acetylneuraminic Acid	68-79	coagulation factor II, thrombin	Homo sapiens	23-31
618863-2	1978	Human antithrombin III was found to contain covalently linked N-acetylglucosamine, mannose, galactose, and sialic acid in a molar ratio of approximately 1:1:0.6:1.	N-Acetylneuraminic Acid	107-118	serpin family C member 1	Homo sapiens	6-22
621288-5	1978	Enzymatic removal of sialic acid from four of the abnormal fibrinogens resulted in a shortening of their thrombin times to the range of the desialylated normal control.	N-Acetylneuraminic Acid	21-32	coagulation factor II, thrombin	Homo sapiens	105-113
618863-3	1978	Sialic acid was released upon treatment with neuraminidase.	N-Acetylneuraminic Acid	0-11	neuraminidase 1	Homo sapiens	45-58
318356-9	1978	The plasma beta-N-acetylglucosaminidase A isoenzyme of all species contained sialic acid residues whereas only the rabbit, pig and calf liver isoenzymes were sialylated.	N-Acetylneuraminic Acid	77-88	O-GlcNAcase	Homo sapiens	11-39
24432-1	1978	An efficient method for the purification of human fibroblast interferon (IF) based on binding via the N-acetyl neuraminic acid (N-ANA) residue of the IF molecules to the immobilized neuraminidase has been developed.	N-Acetylneuraminic Acid	102-126	interferon beta 1	Homo sapiens	50-76
24432-1	1978	An efficient method for the purification of human fibroblast interferon (IF) based on binding via the N-acetyl neuraminic acid (N-ANA) residue of the IF molecules to the immobilized neuraminidase has been developed.	N-Acetylneuraminic Acid	102-126	interferon beta 1	Homo sapiens	73-75
24432-1	1978	An efficient method for the purification of human fibroblast interferon (IF) based on binding via the N-acetyl neuraminic acid (N-ANA) residue of the IF molecules to the immobilized neuraminidase has been developed.	N-Acetylneuraminic Acid	102-126	neuraminidase 1	Homo sapiens	182-195
579296-9	1977	PP5 is a glycoprotein and contains 19.8% carbohydrates (hexoses 10.0%, hexosamine 4.4%, fucose 0.4%, sialic acid 5.0%).	N-Acetylneuraminic Acid	101-112	tissue factor pathway inhibitor 2	Homo sapiens	0-3
21325-7	1977	Neuraminidase treatment of renal tissue removes the sialic acid-dependent glomerular polyanion staining but preserves and stabilizes the complement receptor.	N-Acetylneuraminic Acid	52-63	neuraminidase 1	Homo sapiens	0-13
413796-7	1978	(5) Based on the changes of electrophoretic mobility upon exposure to neuraminidase, the subhuman primate as well as human PAPP-A and PAPP-C appeared to be glycoproteins containing sialic acid.	N-Acetylneuraminic Acid	181-192	neuraminidase 1	Homo sapiens	70-83
413796-7	1978	(5) Based on the changes of electrophoretic mobility upon exposure to neuraminidase, the subhuman primate as well as human PAPP-A and PAPP-C appeared to be glycoproteins containing sialic acid.	N-Acetylneuraminic Acid	181-192	pappalysin 1	Homo sapiens	123-129
412191-9	1977	Liberation of sialic acid from cold agglutinin MKV by treatment with neuraminidase (acylneuraminosyl hydrolase; EC 3.2.1.18) does not affect its agglutinating properties but the asialoprotein is no longer a cryoglobulin.	N-Acetylneuraminic Acid	14-25	neuraminidase 1	Homo sapiens	69-82
561860-6	1977	These data are in accord with the hypothesis that neuraminidase may facilitate production of infectious particles by removing sialic acid residues and exposing appropriate cleavage sites on hemagglutinin.	N-Acetylneuraminic Acid	126-137	neuraminidase 1	Bos taurus	50-63
588668-3	1977	That is a number about 2.5 fold superior to the carboxyl groups of sialic acid as determined by the action of neuraminidase.	N-Acetylneuraminic Acid	67-78	neuraminidase 1	Homo sapiens	110-123
893147-0	1977	5-Brom-3-indolyl-alpha-ketoside of 5-N-acetyl-D-neuraminic acid a new substrate for the light and electron microscopic demonstration of mammalian neuraminidase.	N-Acetylneuraminic Acid	35-63	neuraminidase 1	Homo sapiens	146-159
20208-1	1977	Both the sialoglycoprotein of human erythrocyte membranes, glycophorin, and the sialic acid free protein, obtained by treatment of glycophorin with neuraminidase (EC 3.2.1.18), increase the fluorescence of 8-anilino-1-naphthalene sulfonate (ANS).	N-Acetylneuraminic Acid	80-91	neuraminidase 1	Homo sapiens	148-161
928327-3	1977	To study the role played by sialic acids of transferrin molecule in the formation of complexes with insulin the author used transferrin untreated and treated with neuraminidase, an enzyme splitting the sialic acid molecules from grycoprotein specifically.	N-Acetylneuraminic Acid	28-39	transferrin	Homo sapiens	44-55
928327-3	1977	To study the role played by sialic acids of transferrin molecule in the formation of complexes with insulin the author used transferrin untreated and treated with neuraminidase, an enzyme splitting the sialic acid molecules from grycoprotein specifically.	N-Acetylneuraminic Acid	28-39	insulin	Homo sapiens	100-107
928327-3	1977	To study the role played by sialic acids of transferrin molecule in the formation of complexes with insulin the author used transferrin untreated and treated with neuraminidase, an enzyme splitting the sialic acid molecules from grycoprotein specifically.	N-Acetylneuraminic Acid	28-39	neuraminidase 1	Homo sapiens	163-176
928327-5	1977	Transferrin devoid of sialic acid lost its capacity to form complexes with insulin.	N-Acetylneuraminic Acid	22-33	transferrin	Homo sapiens	0-11
928327-5	1977	Transferrin devoid of sialic acid lost its capacity to form complexes with insulin.	N-Acetylneuraminic Acid	22-33	insulin	Homo sapiens	75-82
928327-7	1977	The results of experiments with the use of neuraminidase demonstrated that sialic acid in donor transferrin molecule could be of great significance in the formation of an insulin-transferrin complex.	N-Acetylneuraminic Acid	75-86	neuraminidase 1	Homo sapiens	43-56
928327-7	1977	The results of experiments with the use of neuraminidase demonstrated that sialic acid in donor transferrin molecule could be of great significance in the formation of an insulin-transferrin complex.	N-Acetylneuraminic Acid	75-86	transferrin	Homo sapiens	96-107
928327-7	1977	The results of experiments with the use of neuraminidase demonstrated that sialic acid in donor transferrin molecule could be of great significance in the formation of an insulin-transferrin complex.	N-Acetylneuraminic Acid	75-86	insulin	Homo sapiens	171-178
928327-7	1977	The results of experiments with the use of neuraminidase demonstrated that sialic acid in donor transferrin molecule could be of great significance in the formation of an insulin-transferrin complex.	N-Acetylneuraminic Acid	75-86	transferrin	Homo sapiens	179-190
70227-8	1977	The slow moving alpha-fetoprotein could be further fractionated on RCAI-sepharose column in two components, AFPA1 and AFPA2 differing by their sialic acid content.	N-Acetylneuraminic Acid	143-154	alpha-fetoprotein	Rattus norvegicus	16-33
914796-4	1977	When this sialic acid-free T-1 fragment was incubated with purified diplococcal endo-alpha-N-acetylgalactosaminidase, all remaining sugars were released as a disaccharide.	N-Acetylneuraminic Acid	10-21	alpha-N-acetylgalactosaminidase	Bos taurus	85-116
16743049-11	1977	The protein alpha-lactalbumin modified the enzyme to a lactose synthetase by increasing substrate specificity for glucose in preference to N-acetylglucosamine and fetuin depleted of sialic acid and galactose.	N-Acetylneuraminic Acid	182-193	lactalbumin, alpha	Rattus norvegicus	12-29
884130-3	1977	In studying the solubility characteristics of thyroglobulin, it was found that the removal of sialic acid residues from either human or hog thyroglobulin by treatment with neuraminidase markedly decreased the solubility in salt solutions.	N-Acetylneuraminic Acid	94-105	thyroglobulin	Homo sapiens	46-59
884130-3	1977	In studying the solubility characteristics of thyroglobulin, it was found that the removal of sialic acid residues from either human or hog thyroglobulin by treatment with neuraminidase markedly decreased the solubility in salt solutions.	N-Acetylneuraminic Acid	94-105	thyroglobulin	Homo sapiens	140-153
884130-3	1977	In studying the solubility characteristics of thyroglobulin, it was found that the removal of sialic acid residues from either human or hog thyroglobulin by treatment with neuraminidase markedly decreased the solubility in salt solutions.	N-Acetylneuraminic Acid	94-105	neuraminidase 1	Homo sapiens	172-185
884130-4	1977	On the other hand, naturally sialic acid-rich thyroglobulin obtained from human diffuse goiter was slightly more soluble than thyroglobulin in which sialic acid content was within the normal range.	N-Acetylneuraminic Acid	29-40	thyroglobulin	Homo sapiens	46-59
884130-4	1977	On the other hand, naturally sialic acid-rich thyroglobulin obtained from human diffuse goiter was slightly more soluble than thyroglobulin in which sialic acid content was within the normal range.	N-Acetylneuraminic Acid	149-160	thyroglobulin	Homo sapiens	46-59
870150-0	1977	Studies on the site of addition of sialic acid and glucosamine to rat alpha 1-acid glycoprotein.	N-Acetylneuraminic Acid	35-46	orosomucoid 1	Rattus norvegicus	70-95
884130-6	1977	These results indicate that the surface charge of thyroglobulin which influenced the salting-out property depends largely on the number of sialic acid residues in a thyroglobulin molecule, not on the degree of iodination of thyroglobulin.	N-Acetylneuraminic Acid	139-150	thyroglobulin	Homo sapiens	50-63
884130-6	1977	These results indicate that the surface charge of thyroglobulin which influenced the salting-out property depends largely on the number of sialic acid residues in a thyroglobulin molecule, not on the degree of iodination of thyroglobulin.	N-Acetylneuraminic Acid	139-150	thyroglobulin	Homo sapiens	165-178
884130-6	1977	These results indicate that the surface charge of thyroglobulin which influenced the salting-out property depends largely on the number of sialic acid residues in a thyroglobulin molecule, not on the degree of iodination of thyroglobulin.	N-Acetylneuraminic Acid	139-150	thyroglobulin	Homo sapiens	165-178
267515-4	1977	Mitotic cells were also found to be more susceptible to neuraminidase than S-phase cells in term of electrophoretic mobility, a greater amount of sialic acid being correspondingly released from the former.	N-Acetylneuraminic Acid	146-157	neuraminidase 1	Homo sapiens	56-69
870150-2	1977	Rough endoplasmic reticulum fractions contained only sialic acid free alpha 1-acid glycoprotein, whereas smooth endoplasmic reticulum and Golgi fractions also contained sialic acid containing alpha 1-acid glycoprotein.	N-Acetylneuraminic Acid	169-180	orosomucoid 1	Rattus norvegicus	192-217
870150-3	1977	Determination of the sialic acid contents of immune precipitates isolated from the extracts suggested that the Golgi complex was the main site of addition of sialic acid to alpha 1-acid glycoprotein.	N-Acetylneuraminic Acid	21-32	orosomucoid 1	Rattus norvegicus	173-198
870150-3	1977	Determination of the sialic acid contents of immune precipitates isolated from the extracts suggested that the Golgi complex was the main site of addition of sialic acid to alpha 1-acid glycoprotein.	N-Acetylneuraminic Acid	158-169	orosomucoid 1	Rattus norvegicus	173-198
849471-6	1977	The heterogeneity of kappa-casein therefore is not exclusively caused by a varying N-acetylneuraminic acid content.	N-Acetylneuraminic Acid	83-106	casein kappa	Bos taurus	21-33
66068-8	1977	The total carbohydrate content was 5.5%, and 3 mol of sialic acid were detected per mol of alpha-fetoprotein.	N-Acetylneuraminic Acid	54-65	alpha fetoprotein	Mus musculus	91-108
403026-4	1977	On the other hand, 4 fractions have been obtained by "DEAE-Sephadex" chromatography, study of which demonstrates that the microheterogeneity of the lactotransferrin depends on the carbohydrate moiety and especially on the N-acetylneuraminic acid content which varies from 0 to 2 residues.	N-Acetylneuraminic Acid	222-245	lactotransferrin	Bos taurus	148-164
558203-3	1977	While maximal sialic acid release was obtained with 5 units neuraminidase/2 x10(9) erythrocytes, maximal concanavalin A agglutination was only obtained after exposure to 20 units neuramindase.	N-Acetylneuraminic Acid	14-25	neuraminidase 2	Homo sapiens	60-75
13077-17	1977	Rat liver lysosomal alpha-glucosidase, also produced in the rapid isolation procedure described herein, contained less than 0.1 residue of sialic acid per subunit.	N-Acetylneuraminic Acid	139-150	alpha glucosidase	Rattus norvegicus	10-37
833473-1	1977	The role of sialic acid in the functional and metabolic properties of purified human fibrinogen was investigated.	N-Acetylneuraminic Acid	12-23	fibrinogen beta chain	Homo sapiens	85-95
833473-2	1977	Fibrinogen treated with Vibrio cholerae neuraminidase released 90 percent of its sialic acid without evidence of proteolysis, as indicated by the presence of intace A alpha, B beta, and gamma chains on sodium dodecylsulfate (SDS)-polyacrylamide gels of the reduced asialoprotein.	N-Acetylneuraminic Acid	81-92	fibrinogen beta chain	Homo sapiens	0-10
576386-8	1977	PP7 is a glycoprotein; its carbohydrate content amounts to 5.4% (hexoses 3.0%, Hexosamine 1.2%, Fucose 0.2%, sialic acid 1.0%).	N-Acetylneuraminic Acid	109-120	protein phosphatase with EF-hand domain 1	Homo sapiens	0-3
900579-0	1977	Polymorphic variation in the amount of sialic acid attached to bovine transferrin.	N-Acetylneuraminic Acid	39-50	serotransferrin	Bos taurus	70-81
900579-1	1977	In this paper family studies are presented which support the hypothesis of polymorphism in the process controlling sialic acid binding to bovine transferrin which modifies its phenotype as seen in starch gel electrophoresis.	N-Acetylneuraminic Acid	115-126	serotransferrin	Bos taurus	145-156
563497-7	1977	Neuraminidase digestion of the isolated proteins resulted in mobility shifts on polyacrylamide gel electrophoresis which were consistent with the interpretation that either the isolated proteins have considerably different sialic acid contents, or that removal of the sialic acid results in disaggregation of an Fc receptor molecule.	N-Acetylneuraminic Acid	268-279	Fc receptor	Mus musculus	312-323
856748-3	1977	The data obtained indicate that the excess number of electrophoretic bands observed in transferrin from this source is due to the loss of carbohydrates which only affects sialic acid and none of the other sugar types.	N-Acetylneuraminic Acid	171-182	transferrin	Homo sapiens	87-98
856748-5	1977	The reason for the gradual loss of sialic acid from transferrin is unknown.	N-Acetylneuraminic Acid	35-46	transferrin	Homo sapiens	52-63
63952-5	1976	Treatment of HAFP with neuraminidase to remove completely sialic acid residues did not alter the biological potency, but converted the three species to two species having slower electrophoretic mobilities.	N-Acetylneuraminic Acid	58-69	neuraminidase 1	Homo sapiens	23-36
1033935-3	1976	Cultured NB41A cells incorporated N-[3H]acetylmannosamine into the sialic acid moiety of GM3 in less than 10 min.	N-Acetylneuraminic Acid	67-78	granulocyte macrophage antigen 3	Mus musculus	89-92
337329-5	1977	After neuraminidase treatment to remove the sialic acid charge groups, these same shape changes were observed in ghosts and whole cells.	N-Acetylneuraminic Acid	44-55	neuraminidase 1	Homo sapiens	6-19
993075-1	1976	Dansylhydrazine, previously introduced in a selective fluorescent cytochemical method for the demonstration of sialic acid residues of cellular glycoconjungates, may be broadly applied as a specific, covalently bonded fluorochrome of aldehyde residues, both those naturally occurring as in elastin or those generated through PAS or Feulgen-type procedures.	N-Acetylneuraminic Acid	111-122	elastin	Homo sapiens	290-297
999886-5	1976	Upon removal of sialic acid by neuraminidase treatment, there is a small increase in this value, while the fluorescence intensity at he emission maximum (357 nm) is distinctly increased.	N-Acetylneuraminic Acid	16-27	neuraminidase 1	Homo sapiens	31-44
64258-2	1976	Following removal of sialic acid by neuraminidase treatment the activity of the beta-glucuronidase inhibitor was remarkably decreased, but the antigenic determinant was not affected.	N-Acetylneuraminic Acid	21-32	neuraminidase 1	Homo sapiens	36-49
64258-2	1976	Following removal of sialic acid by neuraminidase treatment the activity of the beta-glucuronidase inhibitor was remarkably decreased, but the antigenic determinant was not affected.	N-Acetylneuraminic Acid	21-32	glucuronidase beta	Homo sapiens	80-98
1002996-7	1976	Analysis of the carbohydrate moiety in C5a indicated 4 moles of glucosamine, 3 to 4 moles os sialic acid, 4 moles of mannose and 2 moles of galactose.	N-Acetylneuraminic Acid	93-104	complement C5a receptor 1	Homo sapiens	39-42
990326-9	1976	The granule glycoproteins were only partly exposed on the granule membrane since about 50% of the acid-hydrolyzable sialic acid could be liberated by neuraminidase treatment of isolated granules.	N-Acetylneuraminic Acid	116-127	neuraminidase 1	Homo sapiens	150-163
991384-4	1976	It could be demonstrated that N-acetyl neuraminic acid residue of the total hematoside present in the virion is hydrolyzed by neuraminidase leaving the particles fully intact.	N-Acetylneuraminic Acid	30-54	neuraminidase 1	Homo sapiens	126-139
822669-2	1976	Terminal sialic acid and galactose were released by stepwise hydrolysis with neuraminidase and beta-galactosidase.	N-Acetylneuraminic Acid	9-20	neuraminidase 1	Homo sapiens	77-90
948758-1	1976	Specific removal of sialic acid from cultured heart cells with purified neuraminidase increases cellular calcium exchangeability.	N-Acetylneuraminic Acid	20-31	neuraminidase 1	Homo sapiens	72-85
822669-2	1976	Terminal sialic acid and galactose were released by stepwise hydrolysis with neuraminidase and beta-galactosidase.	N-Acetylneuraminic Acid	9-20	galactosidase beta 1	Homo sapiens	95-113
60186-8	1976	The results indicate that sialic acid masks antigenic determinants in human thyroglobulin and that carbohydrates might be the determinants involved in the process of autoimmunization.	N-Acetylneuraminic Acid	26-37	thyroglobulin	Homo sapiens	76-89
975107-5	1976	N-Acetylneuraminic acid was shown to be linked to galactose since its prior removal with neuraminidase led to an equivalent increased destruction of galactose by one treatment with periodate.	N-Acetylneuraminic Acid	0-23	neuraminidase 1	Homo sapiens	89-102
1084886-7	1976	Specifically, the Z-type alpha-1-AT is deficient in 1 glucosamine residue, 3 neutral sugar residues (1 mannose and 2 galactose), and 2 sialic acid residues.	N-Acetylneuraminic Acid	135-146	serpin family A member 1	Homo sapiens	25-35
1085169-1	1976	alpha 1-Antitrypsin phenotypes Pi M and Z, purified by the thiol-disulfide exchange procedure, were desialylated by treatment with neuraminidase covalently coupled to Sepharose and used as acceptors of sialic acid in an assay system for serum sialic acid transferase (CMP-N-acetylneuraminate:D-galactosyl-glycoprotein N-acetylneuraminyltransferase, EC 2.4.99.1) activity.	N-Acetylneuraminic Acid	202-213	serpin family A member 1	Homo sapiens	0-19
56201-1	1976	Results with modified human red cell membrane sialoglycoproteins indicate that alkali-labile sialic acid and amino groups are parts of the erythrocyte receptor sites recognized by common rabbit and human anti-M and -N sera.	N-Acetylneuraminic Acid	93-104	CD2 molecule	Homo sapiens	139-159
182921-0	1976	Neuraminidase-releasable surface sialic acid of cultured astroblasts exposed to ethanol.	N-Acetylneuraminic Acid	33-44	neuraminidase 1	Homo sapiens	0-13
1083250-3	1976	We recently reported that serum from a patient with alpha-1-antitrypsin deficiency and hepatic cirrhosis was substantially deficient in sialyltransferease (EC 2.4.99.1) an enzyme which transfers sialic acid from cytidine 5"-monophosphate-N-acetylneuraminic acid to a variety of asialoglycoprotein acceptors.	N-Acetylneuraminic Acid	195-206	serpin family A member 1	Homo sapiens	52-71
1260011-1	1976	A major glycoprotein 36 000 molecular weight) has been isolated from lung lavage of patients with alveolar proteinosis and found to contain five residues of hydroxyproline, fifty residues of glycine, three residues of methionine, 3 mol of sialic acid, 4.4 mol of mannose, 4.0 mol of galactose, 6.0 mol of glucosamine, and 1 mol of fucose.	N-Acetylneuraminic Acid	239-250	podoplanin	Homo sapiens	8-23
821601-6	1976	The major chemical differences included a higher hexosamine-fucose and hexosamine-sialic acid ratio in human mucin.	N-Acetylneuraminic Acid	82-93	LOC100508689	Homo sapiens	109-114
58044-1	1976	Sialic acid has been shown to be part of the antigenic determinant of the Thy-1.2 alloantigen as expressed by the murine cell line S-49.1 TB-2-3 (S-49).	N-Acetylneuraminic Acid	0-11	thymus cell antigen 1, theta	Mus musculus	74-81
58044-3	1976	Also, sialic acid has the ability to inhibit the cytotoxic assay of AKR anti-C3H Thy-1.2 serum for S-49 cells.	N-Acetylneuraminic Acid	6-17	thymus cell antigen 1, theta	Mus musculus	81-88
1244202-10	1976	Decrease in testicular weight, seminiferous tubule diameter and RNA and sialic acid levels after 4 weeks of vas injection were associated with the histological evidence for severe degeneration of spermatogenic elements.	N-Acetylneuraminic Acid	72-83	arginine vasopressin	Rattus norvegicus	108-111
56198-6	1976	Carbohydrate analysis demonstrated that ApoD is a glycoprotein with glucose, mannose, galactose, glucosamine, and sialic acid accounting for 18% of the dry weight of ApoD.	N-Acetylneuraminic Acid	114-125	apolipoprotein D	Homo sapiens	40-44
1244202-15	1976	Low sialic acid levels in the testis, epididymides and seminal vesicles of vas-injected rats indicated an inhibition of androgen production, which was further reflected in reduced nuclear diameters of leydig cells.	N-Acetylneuraminic Acid	4-15	arginine vasopressin	Rattus norvegicus	75-78
818810-3	1976	The alpha1-acid glycoprotein was modified by removal of sialic acid with neuraminidase (EC 3.2.1.18) followed by iodination with 131I.	N-Acetylneuraminic Acid	56-67	neuraminidase 1	Homo sapiens	73-86
1247183-3	1976	The first of these, sialic acid, was removed with neuraminidase.	N-Acetylneuraminic Acid	20-31	neuraminidase 1	Homo sapiens	50-63
56137-1	1976	Morphologic studies of liver tissue in individuals deficient in alpha-1-antitrypsin (alpha-1-AT) have established the presence of membrane-delimited deposits which are diastase resistant, perodic acid-Schiff positive, sialic acid deficient, and immunologically related to serum alpha-1-AT.	N-Acetylneuraminic Acid	218-229	serpin family A member 1	Homo sapiens	64-83
56137-1	1976	Morphologic studies of liver tissue in individuals deficient in alpha-1-antitrypsin (alpha-1-AT) have established the presence of membrane-delimited deposits which are diastase resistant, perodic acid-Schiff positive, sialic acid deficient, and immunologically related to serum alpha-1-AT.	N-Acetylneuraminic Acid	218-229	serpin family A member 1	Homo sapiens	85-95
183223-3	1976	Pre-treatment values from patients with lung carcinoma showed markedly elevated levels of sialic acid (0.697 +/- 0.149 muM/ml) as compared to those from normal controls (0.432 +/- 0.067 muM/ml).	N-Acetylneuraminic Acid	90-101	latexin	Homo sapiens	119-122
183223-3	1976	Pre-treatment values from patients with lung carcinoma showed markedly elevated levels of sialic acid (0.697 +/- 0.149 muM/ml) as compared to those from normal controls (0.432 +/- 0.067 muM/ml).	N-Acetylneuraminic Acid	90-101	latexin	Homo sapiens	186-189
813583-2	1975	Human tyrosinase is a glycoprotein containing N-acetylneuraminic acid.	N-Acetylneuraminic Acid	46-69	tyrosinase	Homo sapiens	6-16
56186-8	1975	No loss in activity, however, was observed when 5.33mM NaIO4 was used, and one Smith degradation (i.e. treatment in sequence with periodate, borohydride and mild acid) of CEA removed approximately 50% of the carbohydrate, including all of the fucose, sialic acid and 2-acetamido-2-deoxygalactose but did not change the antigenic activity.	N-Acetylneuraminic Acid	251-262	CEA cell adhesion molecule 3	Homo sapiens	171-174
172121-1	1975	Removal of sialic acid from intact mammalian nervous system cells in tissue culture is accompanied by an immediate increase in cellular cholinesterase activity.	N-Acetylneuraminic Acid	11-22	butyrylcholinesterase	Homo sapiens	136-150
1191130-2	1975	Prolactin significantly increased vaginal weight and vaginal sialic acid content, but had no effect on vaginal sialic acid concentration, an indicator of vaginal mucification.	N-Acetylneuraminic Acid	61-72	prolactin	Mus musculus	0-9
1081456-7	1975	It appears to be a sialic acid-containing glycoprotein of molecular weight 45,000-60,000 daltons that migrates electrophoretically between alpha1 globulin and albumin.	N-Acetylneuraminic Acid	19-30	albumin	Homo sapiens	139-166
240423-4	1975	Sheep brain arylsulfatase A has been shown to be a glycoprotein containing 25% neutral sugar and 0.5% sialic acid.	N-Acetylneuraminic Acid	102-113	arylsulfatase A	Ovis aries	12-27
1157755-2	1975	Tumor thyroglobulin had a very low sialic acid and iodine content; after in vivo iodination it contained only small amounts of triiodothyronine (T3) and no detectable thyroxine (T4).	N-Acetylneuraminic Acid	35-46	thyroglobulin	Rattus norvegicus	6-19
1157755-6	1975	These results are compatible with a role for sialic acid in the maturation and migration of thyroglobulin to the iodination site, rpovided that the intracellular distribution of the iodinating enzymes are normal.	N-Acetylneuraminic Acid	45-56	thyroglobulin	Rattus norvegicus	92-105
54173-7	1975	Experiments with neuraminidase-treated platelets revealed that the enzymatically removable sialic acid residues are not those negatively charged binding sites.	N-Acetylneuraminic Acid	91-102	neuraminidase 1	Homo sapiens	17-30
1175751-1	1975	Removal of the cell surface sialic acid with neuraminidase brings about cell deformation in amoeba.	N-Acetylneuraminic Acid	28-39	neuraminidase 1	Homo sapiens	45-58
1169073-2	1975	Both bovine cervical mucus, which is a gel, and the structural glycoprotein derived from it were studied before and after treatment with neuraminidase which selectively cleaves terminal sialic acid residues.	N-Acetylneuraminic Acid	186-197	neuraminidase 1	Bos taurus	137-150
807600-5	1975	Treatment of platelets and Factor VIII with neuraminidase released 60 and 53%, respectively, of the sialic acid residues without affecting the agglutination reaction or the procoagulant activity of the Factor VIII.	N-Acetylneuraminic Acid	100-111	coagulation factor VIII	Bos taurus	27-38
807600-5	1975	Treatment of platelets and Factor VIII with neuraminidase released 60 and 53%, respectively, of the sialic acid residues without affecting the agglutination reaction or the procoagulant activity of the Factor VIII.	N-Acetylneuraminic Acid	100-111	neuraminidase 1	Bos taurus	44-57
1170888-18	1975	On the other hand, GP-1 and GP-2 had nearly identical levels of carbohydrate, 45.1 and 48.0 wt %, and possessed essentially the same percent distribution of carbohydrates: sialic acid, 16.5 plus or minus 0.5; mannose, 10.3 plus or minus 0.4; glucosamine, 11.2 plus or minus 0.1; galactose, 7.9 plus or minus 0.3.	N-Acetylneuraminic Acid	172-183	glycoprotein 2	Bos taurus	19-32
1141384-1	1975	Incubation of HeLa cells in the presence of millimolar concentrations of propionate, butyrate, or pentanoate increases the specific activity of CMP-sialic acid:lactosylceramide sialyltransferase 7-20-fold within 24 h. Longer-chain saturated fatty acids or acetate are much less effective, decanoate showing no induction.	N-Acetylneuraminic Acid	148-159	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	177-194
238599-5	1975	Both phosphatases from callus calcifying cartilage were found to be substrates of neuraminidase with sialic acid as the product.	N-Acetylneuraminic Acid	101-112	neuraminidase 1	Homo sapiens	82-95
1127870-0	1975	Effects on platelet function of removal of platelet sialic acid by neuraminidase.	N-Acetylneuraminic Acid	52-63	neuraminidase 1	Homo sapiens	67-80
1195340-7	1975	Treatment of whole cream with neuraminidase led to the release of at least 70% of the protein-bound sialic acid.	N-Acetylneuraminic Acid	100-111	neuraminidase 1	Homo sapiens	30-43
165982-3	1975	The participation of membrane phospholipids in the binding of insulin and the role of sialic acid residues in the transmission of the insulin binding signal are discussed.	N-Acetylneuraminic Acid	86-97	insulin	Homo sapiens	134-141
165020-1	1975	Incubation of very low density lipoproteins (VLDL) from three hyperlipoproteinemic patients with neuraminidase resulted in a progressive liberation of sialic acid residues.	N-Acetylneuraminic Acid	151-162	neuraminidase 1	Homo sapiens	97-110
236024-5	1975	Binding was markedly reduced, and sigmoidicity abolished, by removal of sialic acid from the mucin, or by adding 0.14 M NaCl to the dialysis medium.	N-Acetylneuraminic Acid	72-83	solute carrier family 13 member 2	Rattus norvegicus	93-98
1079112-4	1975	Results of studies with two different electrophoretic systems suggested that the Z type alpha1 antitrypsin has less sialic acid than the M, F, and S types.	N-Acetylneuraminic Acid	116-127	serpin family A member 1	Homo sapiens	88-106
1127870-2	1975	In this study we have quantitated the amount of sialic acid removed by purified neuraminidase from the surface of washed platelets of man, rabbit, or pig and examined the effects of this removal.	N-Acetylneuraminic Acid	48-59	neuraminidase 1	Homo sapiens	80-93
1079112-6	1975	The two major bands of alpha1 antitrypsin seen in certain electrophoretic systems may reflect a difference of one sialic acid residue.	N-Acetylneuraminic Acid	114-125	serpin family A member 1	Homo sapiens	23-41
1079112-7	1975	It is proposed that the Z protein lacks a carbohydrate chain with two terminal sialic acid residues.	N-Acetylneuraminic Acid	79-90	transmembrane BAX inhibitor motif containing 4	Homo sapiens	24-33
163645-5	1975	Prior removal of sialic acid by neuraminidase treatment led to increased destruction of galactose by periodate.	N-Acetylneuraminic Acid	17-28	neuraminidase 1	Homo sapiens	32-45
165003-3	1975	Fucose and N-acetylneuraminic acid residues are nonreducing terminal groups, and the N-acetylneuraminic acid groups are linked to the D-galactose residues at C-3.	N-Acetylneuraminic Acid	85-108	complement component 3	Gallus gallus	158-161
3147-0	1975	Sialic acid in thyroglobulin.	N-Acetylneuraminic Acid	0-11	thyroglobulin	Homo sapiens	15-28
1112819-0	1975	The site of sialic acid incorporation into thyroglobulin in the thyroid gland.	N-Acetylneuraminic Acid	12-23	thyroglobulin	Rattus norvegicus	43-56
1112819-4	1975	Thyroglobulin, analyzed by equilibrium centrifugation in RbCl, had a median density which varied according to the moiety labeled in the following increasing order: leucine smaller than galactose smaller than sialic acid smaller than iodine.	N-Acetylneuraminic Acid	208-219	thyroglobulin	Rattus norvegicus	0-13
1112819-10	1975	The results indicate that sialic acid is incorporated only in nascent thyroglobulin and not in thyroglobulin molecules already secreted into the follicular lumen.	N-Acetylneuraminic Acid	26-37	thyroglobulin	Rattus norvegicus	70-83
1115774-3	1975	Release of sialic acid by incubation with neuraminidase increased the adsorptivity of the TA3-Ha cell three to fourfold and of the TA3-St cell six- to ten fold.	N-Acetylneuraminic Acid	11-22	RIKEN cDNA 2700049A03 gene	Mus musculus	90-93
1115774-3	1975	Release of sialic acid by incubation with neuraminidase increased the adsorptivity of the TA3-Ha cell three to fourfold and of the TA3-St cell six- to ten fold.	N-Acetylneuraminic Acid	11-22	RIKEN cDNA 2700049A03 gene	Mus musculus	131-134
1126343-8	1975	The purified kappa-casein had a molecular weight of about 20000, an absorption coefficient (see journal for formula) at 280 nm of 10.85 and a sialic acid and phosphorous content of 0.3% (w/w) each.	N-Acetylneuraminic Acid	142-153	kappa-casein	Ovis aries	13-25
1234668-1	1975	The turnover rate of N-acetylneuraminic acid of brain gangliosides (GT1, GD1b, GD1a, GM1) was studied following the injection of 2-14C-acetate.	N-Acetylneuraminic Acid	21-44	beta-1,4-galactosyltransferase 1	Homo sapiens	68-71
48419-14	1975	Treatment with neuraminidase removed the sialic acid content of the molecule, changed the isoelectric focusing patterns, and abolished the chromatographic heterogeneity.	N-Acetylneuraminic Acid	41-52	neuraminidase 1	Homo sapiens	15-28
806863-2	1975	Electrophoretic and enzymatic analyses indicated that the serum and aqueous transferrin, as well as an important part of that of the vitreous, have two residues of sialic acid per molecule.	N-Acetylneuraminic Acid	164-175	serotransferrin	Oryctolagus cuniculus	76-87
1093185-7	1975	Measurements of the sialic acid content of NDV or sham-infected cells before and after neuraminidase treatment indicated the exposure to the enzyme or NDV materially reduced the sialic acid content of cells.	N-Acetylneuraminic Acid	178-189	neuraminidase 1	Homo sapiens	87-100
164087-3	1975	Neuraminidase gradually produces a slight to moderate agglutinability as it reduced surface charge density in proportion to the amount of sialic acid removed.	N-Acetylneuraminic Acid	138-149	neuraminidase 1	Homo sapiens	0-13
164087-6	1975	In the second stage the cells show a slight gain in agglutinability as surface charge is removed in proportion to sialic acid removal as in the case of neuraminidase.	N-Acetylneuraminic Acid	114-125	neuraminidase 1	Homo sapiens	152-165
4139707-3	1974	Neuraminidase (EC 3.2.1.18) treatment of the HL-A antigens as a function of time altered the band patterns in a manner demonstrating that up to three sialic acid residues are present on both first locus ("LA") and second locus ("Four") antigens.	N-Acetylneuraminic Acid	150-161	neuraminidase 1	Homo sapiens	0-13
4372181-2	1974	N-Acetylneuraminic acid was released from the gel by either neuraminidase.	N-Acetylneuraminic Acid	0-23	neuraminidase 1	Bos taurus	60-73
4462752-16	1974	The cholinesterase contained 17.4% carbohydrate including 3.2% N-acetylneuraminic acid.	N-Acetylneuraminic Acid	63-86	butyrylcholinesterase	Homo sapiens	4-18
4369356-0	1974	The role of sialic acid in determining the survival of transcortin in the circulation.	N-Acetylneuraminic Acid	12-23	serpin family A member 6	Homo sapiens	55-66
4369334-1	1974	Influence of neuraminidase treatment on the release of insulin and the islet content of insulin, sialic acid, and cyclic adenosine 3":5"-monophosphate.	N-Acetylneuraminic Acid	97-108	neuraminidase 1	Homo sapiens	13-26
4368980-2	1974	The role of sialic acid in erythropoietin action.	N-Acetylneuraminic Acid	12-23	erythropoietin	Homo sapiens	27-41
4771445-0	1973	Removal of N-acetylneuraminic acid from particulate sialoglycoproteins by endogenous membrane bound neuraminidase in calf brain.	N-Acetylneuraminic Acid	11-34	neuraminidase 1	Bos taurus	100-113
4198961-0	1973	An improved automated method for the estimation of sialic acid released in the neuraminidase assay.	N-Acetylneuraminic Acid	51-62	neuraminidase 1	Homo sapiens	79-92
4118356-8	1972	STBG had about onefourth the sialic acid content of TBG and the electrophoretic mobility of this protein was similar to that of a T(4)-binding protein with a mobility slower than that of TBG which has been seen in the electrophoretic patterns of some normal human serums and in serums of patients with hepatic cirrhosis and which does not appear to be an artifact caused by storage and freezing of serum.	N-Acetylneuraminic Acid	29-40	serpin family A member 7	Homo sapiens	1-4
4121289-10	1973	Evidence that N-acetylneuraminic acid groups are the principal acidic residues binding colloidal iron was the elimination of greater than 85% of the colloidal iron labeling to neuraminidase-treated cell membranes.	N-Acetylneuraminic Acid	14-37	neuraminidase 1	Homo sapiens	176-189
4196191-0	1973	Effects of calcium and bound sialic acid on the viscosity of mucin.	N-Acetylneuraminic Acid	29-40	LOC100508689	Homo sapiens	61-66
4795773-0	1973	Studies on the role of myxovirus neuraminidase in virus-cell receptor interaction by means of direct determination of sialic acid split from cells.	N-Acetylneuraminic Acid	118-129	neuraminidase 1	Homo sapiens	33-46
4118356-8	1972	STBG had about onefourth the sialic acid content of TBG and the electrophoretic mobility of this protein was similar to that of a T(4)-binding protein with a mobility slower than that of TBG which has been seen in the electrophoretic patterns of some normal human serums and in serums of patients with hepatic cirrhosis and which does not appear to be an artifact caused by storage and freezing of serum.	N-Acetylneuraminic Acid	29-40	serpin family A member 7	Homo sapiens	52-55
4114435-3	1972	Thus, in a single coupled system neuraminidase releases N-acetylneuraminic acid, which is cleaved to N-acetyl-D-mannosamine and pyruvic acid; finally, pyruvate is reduced to lactate as reduced nicotinamide adenine dinucleotide is oxidized.	N-Acetylneuraminic Acid	56-79	neuraminidase 1	Homo sapiens	33-46
5080374-0	1972	Studies on the role of sialic acid in the physical and biological properties of erythropoietin.	N-Acetylneuraminic Acid	23-34	erythropoietin	Homo sapiens	80-94
4639018-3	1972	The activity of the N-acetylgalactosamine-cleaving enzyme (hexosaminidase) is drastically diminished in such preparations from Tay-Sachs brain whereas the activity of the N-acetylneuraminic acid-cleaving enzyme (neuraminidase) is at a normal level.	N-Acetylneuraminic Acid	171-194	neuraminidase 1	Homo sapiens	212-225
5063546-0	1972	Biological properties of hCG after removal of terminal sialic acid and galactose residues.	N-Acetylneuraminic Acid	55-66	hypertrichosis 2 (generalised, congenital)	Homo sapiens	25-28
4114435-5	1972	This procedure, which measures the rate of release of N-acetylneuraminic acid by neuraminidase, is an alternate method for those procedures which require multistep, colorimetric determinations.	N-Acetylneuraminic Acid	54-77	neuraminidase 1	Homo sapiens	81-94
28603927-5	1971	The urato-binding alpha1-2 globulin contains 12.1% of carbohydrates including galactose, mannoso, galactosamine and sialic acid.	N-Acetylneuraminic Acid	116-127	adrenoceptor alpha 1D	Homo sapiens	18-26
4651582-0	1972	[Changes in N-acetylneuraminic acid content of the eel intestine after hypophysectomy and treatment with prolactin].	N-Acetylneuraminic Acid	12-35	prolactin	Homo sapiens	105-114
5124387-10	1971	An approximate correlation exists between the calcium uptake and the sialic acid content of erythrocytes of various species and of human erythrocytes that have been partially depleted of sialic acid by treatment with neuraminidase.	N-Acetylneuraminic Acid	69-80	neuraminidase 1	Homo sapiens	217-230
5124387-10	1971	An approximate correlation exists between the calcium uptake and the sialic acid content of erythrocytes of various species and of human erythrocytes that have been partially depleted of sialic acid by treatment with neuraminidase.	N-Acetylneuraminic Acid	187-198	neuraminidase 1	Homo sapiens	217-230
5493482-0	1970	Metabolic studies on sialic acid-free haptoglobin.	N-Acetylneuraminic Acid	21-32	haptoglobin	Homo sapiens	38-49
5124778-11	1971	The carbohydrate moiety consisted of 0.4g of hexose, 0.77g of hexosamine and 0.18g of sialic acid/100g of vitellogenin.	N-Acetylneuraminic Acid	86-97	a1-a	Xenopus laevis	106-118
5418476-3	1970	Radioactive gangliosides were isolated and selectively degraded with bacterial neuraminidase and rat liver beta-galactosidase to Tay-Sachs ganglioside-(3)H. Radioactivity in the labeled product was confined to the N-acetyl-neuraminic acid portion of the molecule.	N-Acetylneuraminic Acid	214-238	galactosidase, beta 1	Rattus norvegicus	107-125
4306463-7	1969	Terminal sialic acid residues are attached to galactopyranose residues by 2,3-linkages, and to some N-acetylgalactosamine residues (at C-6).	N-Acetylneuraminic Acid	9-20	complement C6	Bos taurus	135-138
4306303-5	1969	By the action of viral neuraminidase, bound N-acetylneuraminic acid was also liberated from purified virus receptor substance whose electrophoretic mobility was thereby substantially reduced.	N-Acetylneuraminic Acid	44-67	neuraminidase 1	Homo sapiens	23-36
4974308-20	1969	Total carbohydrates, protein-bound hexoses, sialic acid, and hexosamine were decreased in the abnormal fibrinogen.	N-Acetylneuraminic Acid	44-55	fibrinogen beta chain	Homo sapiens	103-113
5916390-2	1966	Preparation of radioactive, sialic acid-free ceruloplasmin labeled with tritium on terminal D-galactose residues.	N-Acetylneuraminic Acid	28-39	ceruloplasmin	Homo sapiens	45-58
5690539-6	1968	Transferrin has most of its carbohydrate in a single unit composed of 2 residues of mannose, 2 residues of galactose, 3 residues of N-acetylglucosamine and either 1 or 2 residues of sialic acid.	N-Acetylneuraminic Acid	182-193	transferrin	Homo sapiens	0-11
5680422-0	1968	Serum sialic acid estimation as an aid in differentiating hepatocellular from obstructive jaundice.	N-Acetylneuraminic Acid	6-17	activation induced cytidine deaminase	Homo sapiens	35-38
6049914-6	1967	Mild acid hydrolysis and treatment with neuraminidase showed that fucose and sialic acid occupy terminal positions on oligosaccharide chains.	N-Acetylneuraminic Acid	77-88	neuraminidase 1	Bos taurus	40-53
6049914-8	1967	Treatment of the sialic acid-free glycoprotein with beta-galactosidase showed that much of the galactose occupies a sub-terminal location in the intact glycoprotein.	N-Acetylneuraminic Acid	17-28	galactosidase beta 1	Bos taurus	52-70
4960891-4	1967	Strain 6646 (group K) and strain D 168A "X" (group M) completely broke down and strain H 60R (group F) incompletely broke down bound sialic acid of bovine submaxillary mucin added to the growth medium.	N-Acetylneuraminic Acid	133-144	mucin 1, cell surface associated	Bos taurus	168-173
4960891-10	1967	Sialic acid was detected in the reaction product of the streptococcal sialidase and bovine submaxillary mucin.	N-Acetylneuraminic Acid	0-11	mucin 1, cell surface associated	Bos taurus	104-109
5646187-1	1968	A ganglioside, previously designated HG-B in our laboratory, was isolated from mixed human brain ganglioside preparations and shown to contain equimolar quantities of sialic acid, galactose, and sphingosine.	N-Acetylneuraminic Acid	167-178	cytoglobin	Homo sapiens	37-41
5635941-1	1968	V. Metabolic studies on sialic acid-free ceruloplasmin in vivo.	N-Acetylneuraminic Acid	24-35	ceruloplasmin	Homo sapiens	41-54
4302828-0	1967	[Influence of the administration of ACTH on the sialic acid content of normal human nasal secretion].	N-Acetylneuraminic Acid	48-59	proopiomelanocortin	Homo sapiens	36-40
6029825-4	1967	The presence of sialic acid was detected colorimetrically by use of Warren"s Thiobarbituric Acid Assay after drugs had been added to inhibit the action of neuraminidase on the calf brain substrate.	N-Acetylneuraminic Acid	16-27	neuraminidase 1	Bos taurus	155-168
14247724-14	1964	If neuraminidase-treated cells are sensitized with sialic acid-containing protein, the lysis of these cells by complement is inhibited.	N-Acetylneuraminic Acid	51-62	neuraminidase 1	Homo sapiens	3-16
16749134-5	1965	The latter glycoproteins interacted with chondromucoprotein after mild acid hydrolysis or neuraminidase treatment, complex-formation being inversely related to their sialic acid content.	N-Acetylneuraminic Acid	166-177	neuraminidase 1	Homo sapiens	90-103
5839460-0	1965	The sialic acid of prothrombin.	N-Acetylneuraminic Acid	4-15	coagulation factor II, thrombin	Homo sapiens	19-30
14348196-20	1965	The native mucin contained sialic acid, which was cleaved by the acid environment used in the treatment with pepsin.	N-Acetylneuraminic Acid	27-38	LOC100508689	Homo sapiens	11-16
14483938-3	1962	These components appeared to represent the stepwise removal of the four sialic acid residues from the transferrin molecule, and at large enzyme concentrations, almost all of the transferrin was reduced to the position of the slowest moving component.	N-Acetylneuraminic Acid	72-83	transferrin	Homo sapiens	102-113
14112276-4	1963	The faint components migrated slightly more rapidly than the corresponding components in the stepwise pattern produced by the action of neuraminidase in removing sialic acid from transferrin.	N-Acetylneuraminic Acid	162-173	neuraminidase 1	Homo sapiens	136-149
14112276-4	1963	The faint components migrated slightly more rapidly than the corresponding components in the stepwise pattern produced by the action of neuraminidase in removing sialic acid from transferrin.	N-Acetylneuraminic Acid	162-173	transferrin	Homo sapiens	179-190
14483938-9	1962	The transferrin pattern of cord blood showed a prominent band in the position of transferrin C, accompanied by four faint slower moving bands which coincided with the four transferrin components produced by the action of neuraminidase on transferrin C. The transferrin pattern of cerebrospinal fluid in individuals homozygous for serum transferrin C showed two principal components, one of which appeared to contain no sialic acid.	N-Acetylneuraminic Acid	419-430	neuraminidase 1	Homo sapiens	221-234
13928162-0	1963	Sialic acid in fibrinogen and "vulcanization" of the fibrin clot.	N-Acetylneuraminic Acid	0-11	fibrinogen beta chain	Homo sapiens	15-25
13885922-13	1961	As this surface material resembles, in its initial rate of reaction with neuraminidase, human urinary mucoprotein, the sialic acid is presumably present as an alpha-ketoside.	N-Acetylneuraminic Acid	119-130	neuraminidase 1	Homo sapiens	73-86
13732863-0	1961	Alterations in sialic acid content of human transferrin.	N-Acetylneuraminic Acid	15-26	transferrin	Homo sapiens	44-55
14483938-3	1962	These components appeared to represent the stepwise removal of the four sialic acid residues from the transferrin molecule, and at large enzyme concentrations, almost all of the transferrin was reduced to the position of the slowest moving component.	N-Acetylneuraminic Acid	72-83	transferrin	Homo sapiens	178-189
13732863-2	1961	Sialic acid analysis after starch block electrophoresis suggested that the bands represented the stepwise removal of sialic acid from the transferrin molecule.	N-Acetylneuraminic Acid	0-11	transferrin	Homo sapiens	138-149
13732863-2	1961	Sialic acid analysis after starch block electrophoresis suggested that the bands represented the stepwise removal of sialic acid from the transferrin molecule.	N-Acetylneuraminic Acid	117-128	transferrin	Homo sapiens	138-149
14483938-9	1962	The transferrin pattern of cord blood showed a prominent band in the position of transferrin C, accompanied by four faint slower moving bands which coincided with the four transferrin components produced by the action of neuraminidase on transferrin C. The transferrin pattern of cerebrospinal fluid in individuals homozygous for serum transferrin C showed two principal components, one of which appeared to contain no sialic acid.	N-Acetylneuraminic Acid	419-430	transferrin	Homo sapiens	4-15
34002197-6	2021	The regulation of several alpha2,6 sialyltransferase genes was coincident with the regulation of the alpha2,6 sialic acid on the two cell lines.	N-Acetylneuraminic Acid	110-121	glycoprotein hormone subunit alpha 2	Homo sapiens	26-32
13840007-0	1959	KENKEL H: Relationship of sialic acid and C-reactive protein levels in human serum.	N-Acetylneuraminic Acid	26-37	C-reactive protein	Homo sapiens	42-60
13808770-0	1959	[Effect of parathyroid hormone on serum sialic acid in the rat].	N-Acetylneuraminic Acid	40-51	parathyroid hormone	Rattus norvegicus	11-30
33340149-3	2021	Cell surface sialic acids are sensed by complement factor H (FH) to inhibit complement activation or by sialic acid-binding immunoglobulin-like lectin (SIGLEC) receptors to inhibit microglial activation, phagocytosis, and oxidative burst.	N-Acetylneuraminic Acid	13-24	complement factor H	Homo sapiens	51-59
33340149-3	2021	Cell surface sialic acids are sensed by complement factor H (FH) to inhibit complement activation or by sialic acid-binding immunoglobulin-like lectin (SIGLEC) receptors to inhibit microglial activation, phagocytosis, and oxidative burst.	N-Acetylneuraminic Acid	13-24	complement factor H	Homo sapiens	61-63
33340149-9	2021	Thus, cell surface sialylation recognized by FH, SIGLEC, and other immune-related receptors acts as a major checkpoint inhibitor of innate immune responses in the central nervous system, while excessive cleavage of sialic acid residues and consequently removing this checkpoint inhibitor may trigger lipid accumulation, protein aggregation, inflammation, and neurodegeneration.	N-Acetylneuraminic Acid	215-226	complement factor H	Homo sapiens	45-47
33862140-1	2021	Lysosomal free sialic acid storage disorder (FSASD) is an extremely rare, autosomal recessive, neurodegenerative, multisystemic disorder caused by defects in the lysosomal sialic acid membrane exporter SLC17A5 (sialin).	N-Acetylneuraminic Acid	15-26	solute carrier family 17 member 5	Homo sapiens	202-209
33862140-1	2021	Lysosomal free sialic acid storage disorder (FSASD) is an extremely rare, autosomal recessive, neurodegenerative, multisystemic disorder caused by defects in the lysosomal sialic acid membrane exporter SLC17A5 (sialin).	N-Acetylneuraminic Acid	15-26	solute carrier family 17 member 5	Homo sapiens	211-217
33862140-1	2021	Lysosomal free sialic acid storage disorder (FSASD) is an extremely rare, autosomal recessive, neurodegenerative, multisystemic disorder caused by defects in the lysosomal sialic acid membrane exporter SLC17A5 (sialin).	N-Acetylneuraminic Acid	172-183	solute carrier family 17 member 5	Homo sapiens	202-209
33862140-1	2021	Lysosomal free sialic acid storage disorder (FSASD) is an extremely rare, autosomal recessive, neurodegenerative, multisystemic disorder caused by defects in the lysosomal sialic acid membrane exporter SLC17A5 (sialin).	N-Acetylneuraminic Acid	172-183	solute carrier family 17 member 5	Homo sapiens	211-217
33862140-2	2021	SLC17A5 defects cause free sialic acid and some other acidic hexoses to accumulate in lysosomes, resulting in enlarged lysosomes in some cell types and 10-100-fold increased urinary excretion of free sialic acid.	N-Acetylneuraminic Acid	27-38	solute carrier family 17 member 5	Homo sapiens	0-7
33862140-2	2021	SLC17A5 defects cause free sialic acid and some other acidic hexoses to accumulate in lysosomes, resulting in enlarged lysosomes in some cell types and 10-100-fold increased urinary excretion of free sialic acid.	N-Acetylneuraminic Acid	200-211	solute carrier family 17 member 5	Homo sapiens	0-7
33746065-11	2021	Tilapia Neu4 decreased sialic acid level of both nuclear glycoproteins as well as glycolipids.	N-Acetylneuraminic Acid	23-34	sialidase 4	Mus musculus	8-12
33539598-1	2021	Genome-wide association studies demonstrated that polymorphisms in the CD33/sialic acid-binding immunoglobulin-like lectin 3 gene are associated with late-onset Alzheimer"s disease (AD).	N-Acetylneuraminic Acid	76-87	CD33 molecule	Homo sapiens	71-75
34015330-6	2021	We discovered that CDP-ribitol transport relies on the CMP-sialic acid transporter SLC35A1 and the transporter SLC35A4 in a redundant manner.	N-Acetylneuraminic Acid	59-70	solute carrier family 35 member A1	Homo sapiens	83-90
33909065-5	2021	In particular, a flat sialic acid-binding domain was proposed at the N-terminal domain (NTD) of the spike protein, which may lead to the initial contact and interaction of the virus on the epithelium followed by higher affinity binding to ACE2 receptor, likely a two-step attachment fashion.	N-Acetylneuraminic Acid	22-33	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	100-105
33584010-3	2021	In this work, we fabricated an aptasensor, majorly capitalizing the eminent affinity between sialic acid-binding immunoglobulin (Ig)-like lectin 5 (Siglec-5) and nucleic acids aptamer (K19), with nontoxic MoS2@Au nanocomposites as electrochemiluminescence (ECL) emitters based on exonuclease III (Exo III)-powered DNA walker for the bioassays of Siglec-5.	N-Acetylneuraminic Acid	93-104	sialic acid binding Ig like lectin 5	Homo sapiens	148-156
33584010-3	2021	In this work, we fabricated an aptasensor, majorly capitalizing the eminent affinity between sialic acid-binding immunoglobulin (Ig)-like lectin 5 (Siglec-5) and nucleic acids aptamer (K19), with nontoxic MoS2@Au nanocomposites as electrochemiluminescence (ECL) emitters based on exonuclease III (Exo III)-powered DNA walker for the bioassays of Siglec-5.	N-Acetylneuraminic Acid	93-104	keratin 19	Homo sapiens	185-188
33584010-3	2021	In this work, we fabricated an aptasensor, majorly capitalizing the eminent affinity between sialic acid-binding immunoglobulin (Ig)-like lectin 5 (Siglec-5) and nucleic acids aptamer (K19), with nontoxic MoS2@Au nanocomposites as electrochemiluminescence (ECL) emitters based on exonuclease III (Exo III)-powered DNA walker for the bioassays of Siglec-5.	N-Acetylneuraminic Acid	93-104	sialic acid binding Ig like lectin 5	Homo sapiens	346-354
34013301-2	2021	Cross-reactive antibodies specifically recognized the sialic acid moiety on N-linked glycans of the Spike protein and do not neutralize in vitro SARS-CoV-2.	N-Acetylneuraminic Acid	54-65	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	100-105
33788378-0	2021	The importance of sialic acid, pH and ion concentration on the interaction of uromodulin and complement factor H. Uromodulin (UMOD) can bind complement factor H (cFH) and inhibit the activation of complement alternative pathway (AP) by enhancing the cofactor activity of cFH on degeneration of C3b.	N-Acetylneuraminic Acid	18-29	uromodulin	Homo sapiens	114-124
33788378-0	2021	The importance of sialic acid, pH and ion concentration on the interaction of uromodulin and complement factor H. Uromodulin (UMOD) can bind complement factor H (cFH) and inhibit the activation of complement alternative pathway (AP) by enhancing the cofactor activity of cFH on degeneration of C3b.	N-Acetylneuraminic Acid	18-29	uromodulin	Homo sapiens	126-130
33788378-4	2021	The levels of sialic acid on UMOD, from healthy controls and patients with chronic kidney disease (CKD), were also detected by lectin-ELISA.	N-Acetylneuraminic Acid	14-25	uromodulin	Homo sapiens	29-33
33996901-7	2021	Interestingly, Siglec-10 exhibited dramatic binding divergence toward a pair of Neu5Ac-containing asymmetric N-glycan isomers, as well as their Neu5Gc-containing counterparts.	N-Acetylneuraminic Acid	80-86	sialic acid binding Ig like lectin 10	Homo sapiens	15-24
33909065-5	2021	In particular, a flat sialic acid-binding domain was proposed at the N-terminal domain (NTD) of the spike protein, which may lead to the initial contact and interaction of the virus on the epithelium followed by higher affinity binding to ACE2 receptor, likely a two-step attachment fashion.	N-Acetylneuraminic Acid	22-33	angiotensin converting enzyme 2	Homo sapiens	239-243
32814838-4	2021	Although this reduction in surface-bound FH on PNH RBCs was accompanied by decreased surface sialic acid levels, the enzymatic removal of sialic acids from these RBCs did not significantly affect the levels of surface-bound FH.	N-Acetylneuraminic Acid	93-104	complement factor H	Homo sapiens	41-43
33893973-0	2021	Population Pharmacokinetic Model of N-acetylmannosamine (ManNAc) and N-acetylneuraminic acid (Neu5Ac) in Subjects with GNE Myopathy.	N-Acetylneuraminic Acid	94-100	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	119-122
33893973-1	2021	BACKGROUND: GNE myopathy is a rare genetic muscle disease resulting from deficiency in an enzyme critical for the biosynthesis of N-acetylneuraminic acid (Neu5Ac, sialic acid).	N-Acetylneuraminic Acid	130-153	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	12-15
33893973-1	2021	BACKGROUND: GNE myopathy is a rare genetic muscle disease resulting from deficiency in an enzyme critical for the biosynthesis of N-acetylneuraminic acid (Neu5Ac, sialic acid).	N-Acetylneuraminic Acid	155-161	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	12-15
33893973-1	2021	BACKGROUND: GNE myopathy is a rare genetic muscle disease resulting from deficiency in an enzyme critical for the biosynthesis of N-acetylneuraminic acid (Neu5Ac, sialic acid).	N-Acetylneuraminic Acid	163-174	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	12-15
33893973-2	2021	The uncharged Neu5Ac precursor, N-acetylmannosamine (ManNAc), is under development as an orphan drug for treating GNE myopathy.	N-Acetylneuraminic Acid	14-20	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	114-117
33893973-9	2021	CONCLUSIONS: This population pharmacokinetic model can be used to evaluate ManNAc dosing regimens and to calculate Neu5Ac production and exposure following oral administration of ManNAc in subjects with GNE myopathy.	N-Acetylneuraminic Acid	115-121	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	203-206
32845322-1	2021	CD33-related Siglecs are often found on innate immune cells and modulate their reactivity by recognition of sialic acid-based "self-associated molecular patterns" (SAMPs) and signaling via intracellular tyrosine-based cytosolic motifs.	N-Acetylneuraminic Acid	108-119	CD33 molecule	Homo sapiens	0-4
32791164-1	2021	BACKGROUND: The immunoinhibitory receptor Siglec-8 on the surface of human eosinophils and mast cells binds to sialic acid-containing ligands in the local milieu resulting in eosinophil apoptosis, inhibition of mast cell degranulation and suppression of inflammation.	N-Acetylneuraminic Acid	111-122	sialic acid binding Ig like lectin 8	Homo sapiens	42-50
33615893-3	2021	Soluble klotho was previously determined to increase TRPV5 by cleaving sialic acid, causing TRPV5 to bind to membrane protein galectin-1.	N-Acetylneuraminic Acid	71-82	klotho	Mus musculus	8-14
33615893-3	2021	Soluble klotho was previously determined to increase TRPV5 by cleaving sialic acid, causing TRPV5 to bind to membrane protein galectin-1.	N-Acetylneuraminic Acid	71-82	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	53-58
33615893-3	2021	Soluble klotho was previously determined to increase TRPV5 by cleaving sialic acid, causing TRPV5 to bind to membrane protein galectin-1.	N-Acetylneuraminic Acid	71-82	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	92-97
33615893-3	2021	Soluble klotho was previously determined to increase TRPV5 by cleaving sialic acid, causing TRPV5 to bind to membrane protein galectin-1.	N-Acetylneuraminic Acid	71-82	lectin, galactose binding, soluble 1	Mus musculus	126-136
33615893-4	2021	However, a recent study showed that soluble klotho binds to alpha2-3-sialyllactose - where sialic acid is located - on TRPV5, rather than cleave it.	N-Acetylneuraminic Acid	91-102	klotho	Mus musculus	44-50
33615893-4	2021	However, a recent study showed that soluble klotho binds to alpha2-3-sialyllactose - where sialic acid is located - on TRPV5, rather than cleave it.	N-Acetylneuraminic Acid	91-102	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	60-68
33615893-4	2021	However, a recent study showed that soluble klotho binds to alpha2-3-sialyllactose - where sialic acid is located - on TRPV5, rather than cleave it.	N-Acetylneuraminic Acid	91-102	transient receptor potential cation channel, subfamily V, member 5	Mus musculus	119-124
33314123-10	2021	Additional results show inhibiting NEU activity significantly increases sialic acid-containing N-glycan levels.	N-Acetylneuraminic Acid	72-83	neuraminidase 1	Mus musculus	35-38
33889819-6	2021	Further advanced MS analysis showed the additional sialic acid is bonded through an alpha2-6 linkage to the peripheral N-acetylglucosamine residue.	N-Acetylneuraminic Acid	51-62	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	84-92
33792183-7	2021	ST6GalNAc-I is an O-glycosyltransferase, which catalyzes the addition of sialic acid (SA) to the initiating GalNAc residues forming sialyl Tn (STn) on glycoproteins, such as mucins.	N-Acetylneuraminic Acid	73-84	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	Mus musculus	0-11
33792183-7	2021	ST6GalNAc-I is an O-glycosyltransferase, which catalyzes the addition of sialic acid (SA) to the initiating GalNAc residues forming sialyl Tn (STn) on glycoproteins, such as mucins.	N-Acetylneuraminic Acid	86-88	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	Mus musculus	0-11
33666065-1	2021	The sialic acid-binding immunoglobulin-type lectin Siglec-15 is a promising target to cancer immunotherapy in several tumor types.	N-Acetylneuraminic Acid	4-15	sialic acid binding Ig like lectin 15	Homo sapiens	51-60
33720433-1	2021	CD33 is a Siglec (sialic acid-binding immunoglobulin-type lectin) receptor on microglia.	N-Acetylneuraminic Acid	18-29	CD33 molecule	Homo sapiens	0-4
33720433-2	2021	Human CD33 can be alternatively spliced into two isoforms: the long isoform (CD33M) and a shorter isoform (CD33m) that lacks the sialic acid binding site.	N-Acetylneuraminic Acid	129-140	CD33 molecule	Homo sapiens	6-10
33658363-5	2021	Further characterizing HMGB1 as a sialic acid-binding lectin, we found that optimal binding takes place at normal blood pH and is markedly reduced when pH is adjusted with lactic acid to levels found in sepsis.	N-Acetylneuraminic Acid	34-45	high mobility group box 1	Homo sapiens	23-28
33082599-6	2021	One of the possible inhibition pathways is the competitive binding with the angiotension-converting enzyme-2 (ACE-2), in particular with the cellular Sialic acid (Neu5Ac).	N-Acetylneuraminic Acid	150-161	angiotensin converting enzyme 2	Homo sapiens	110-115
33082599-6	2021	One of the possible inhibition pathways is the competitive binding with the angiotension-converting enzyme-2 (ACE-2), in particular with the cellular Sialic acid (Neu5Ac).	N-Acetylneuraminic Acid	163-169	angiotensin converting enzyme 2	Homo sapiens	110-115
33732900-2	2021	Immobilized neuraminidase can selectively remove terminal N-acetyl neuraminic acid from glycoproteins without altering the protein backbone while it can be easily removed from the reaction mixture avoiding sample contamination.	N-Acetylneuraminic Acid	58-82	neuraminidase 1	Bos taurus	12-25
33732900-13	2021	General significance: Immobilized neuraminidase would contribute to understand the role of sialic acid in biological processes.	N-Acetylneuraminic Acid	91-102	neuraminidase 1	Bos taurus	34-47
33603893-2	2021	The tissue injury caused by diabetic vascular complications can induce a release of sialic acid (SA) into the general circulation leading to increased levels.	N-Acetylneuraminic Acid	84-95	acyl-CoA synthetase medium chain family member 3	Homo sapiens	97-99
33528297-9	2021	Moreover, these cells differentiated into cells of all three germ layers and showed significantly higher levels of alpha 2-6 sialic acid (Sia)-specific lectins, known as differentiation potential markers of human MSCs, than ADSCs.	N-Acetylneuraminic Acid	125-136	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	115-124
32303557-5	2021	Slc35a1 encodes the CMP-sialic acid transporter that transports CMP-sialic acid from cytoplasm into the Golgi apparatus for sialylation.	N-Acetylneuraminic Acid	24-35	solute carrier family 35 (CMP-sialic acid transporter), member 1	Mus musculus	0-7
32303557-5	2021	Slc35a1 encodes the CMP-sialic acid transporter that transports CMP-sialic acid from cytoplasm into the Golgi apparatus for sialylation.	N-Acetylneuraminic Acid	68-79	solute carrier family 35 (CMP-sialic acid transporter), member 1	Mus musculus	0-7
33029681-0	2021	Tissue specific expression of sialic acid metabolic pathway: role in GNE myopathy.	N-Acetylneuraminic Acid	30-41	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	69-72
33029681-2	2021	Biallelic mutations in the rate-limiting enzyme UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine-kinase (GNE) of sialic acid (SA) biosynthetic pathway, was shown to be the cause of this disease.	N-Acetylneuraminic Acid	120-131	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	48-110
33029681-2	2021	Biallelic mutations in the rate-limiting enzyme UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine-kinase (GNE) of sialic acid (SA) biosynthetic pathway, was shown to be the cause of this disease.	N-Acetylneuraminic Acid	120-131	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	112-115
33029681-2	2021	Biallelic mutations in the rate-limiting enzyme UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine-kinase (GNE) of sialic acid (SA) biosynthetic pathway, was shown to be the cause of this disease.	N-Acetylneuraminic Acid	120-131	acyl-CoA synthetase medium chain family member 3	Homo sapiens	133-135
33677598-7	2021	To determine whether higher expression levels of NEU1 in uveitic RMG correlate with desialylation of retinal cells, we performed lectin binding assays with sialic acid-specific lectins.	N-Acetylneuraminic Acid	156-167	neuraminidase 1	Equus caballus	49-53
33708213-4	2021	Sialic acid-binding immunoglobulin-type lectin-G (Siglec-G), a CD33 group of Siglec expressed in B-1a cells and other hematopoietic cells, plays an important immunoregulatory role.	N-Acetylneuraminic Acid	0-11	CD33 molecule	Homo sapiens	63-67
33732239-13	2021	In conclusion, the SV-to-LA substitution in the C-terminal regions of FH and FHR-1 diminishes its sialic acid-binding ability and results in an FHR-1 molecule that only moderately deregulates FH.	N-Acetylneuraminic Acid	98-109	complement factor H related 1	Homo sapiens	77-82
33314603-1	2021	CD22, a member of Siglec family of sialic acid binding proteins, has restricted expression on B cells.	N-Acetylneuraminic Acid	35-46	CD22 molecule	Homo sapiens	0-4
33225515-1	2021	UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is necessary for sialic acid biosynthesis.	N-Acetylneuraminic Acid	86-97	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-62
33558588-3	2021	Cleavage of sialic acid from microfibrils by the sialidase isozyme Neu1 facilitates elastic fiber assembly.	N-Acetylneuraminic Acid	12-23	neuraminidase 1	Rattus norvegicus	67-71
33007530-0	2021	The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption.	N-Acetylneuraminic Acid	10-21	sialic acid binding Ig like lectin 9	Homo sapiens	57-65
33007530-0	2021	The human sialic acid-binding immunoglobulin-like lectin Siglec-9 and its murine homolog Siglec-E control osteoclast activity and bone resorption.	N-Acetylneuraminic Acid	10-21	sialic acid binding Ig-like lectin E	Mus musculus	89-97
33007530-3	2021	Sialic acid-binding immunoglobulin-like lectin (Siglec)-9 and its murine homolog Siglec-E are sialic acid-recognizing inhibitory receptors from the CD33-related Siglec-family and mainly expressed on myeloid cells.	N-Acetylneuraminic Acid	94-105	sialic acid binding Ig-like lectin E	Mus musculus	0-57
33007530-3	2021	Sialic acid-binding immunoglobulin-like lectin (Siglec)-9 and its murine homolog Siglec-E are sialic acid-recognizing inhibitory receptors from the CD33-related Siglec-family and mainly expressed on myeloid cells.	N-Acetylneuraminic Acid	94-105	sialic acid binding Ig-like lectin E	Mus musculus	81-89
33007530-3	2021	Sialic acid-binding immunoglobulin-like lectin (Siglec)-9 and its murine homolog Siglec-E are sialic acid-recognizing inhibitory receptors from the CD33-related Siglec-family and mainly expressed on myeloid cells.	N-Acetylneuraminic Acid	94-105	CD33 antigen	Mus musculus	148-152
33225515-1	2021	UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) is necessary for sialic acid biosynthesis.	N-Acetylneuraminic Acid	86-97	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	64-67
33410905-0	2021	MD Simulation of the Interaction between Sialoglycans and the Second Sialic Acid Binding Site of Influenza A Virus N1 Neuraminidase.	N-Acetylneuraminic Acid	69-80	neuraminidase 1	Homo sapiens	118-131
33167210-3	2021	In this study, we developed a novel, high-throughput PSA glycopeptide workflow, based on matrix-assisted laser desorption/ionization-mass spectrometry, allowing the discrimination of sialic acid linkage isomers via the derivatization of glycopeptides.	N-Acetylneuraminic Acid	183-194	kallikrein related peptidase 3	Homo sapiens	53-56
33384114-6	2021	In addition, good repeatability and robustness for the relative areas of the individual glycoforms and average number of Neu5Ac per EPO molecule were observed.	N-Acetylneuraminic Acid	121-127	erythropoietin	Homo sapiens	132-135
33440845-6	2021	N-glycan analysis with mass spectrometry indeed demonstrated heterogeneous glycosylation for recombinant C1-INH containing terminal galactose and terminal sialic acid.	N-Acetylneuraminic Acid	155-166	serpin family G member 1	Homo sapiens	105-111
33389218-2	2021	A sialic acid (SA)-modified liposomal (SAL) formulation, based on the high expression of L-selectin in peripheral blood neutrophils (PBNs) and SA as its targeting ligand, has proved to be an effective neutrophil-mediated drug delivery system targeting rheumatoid arthritis (RA).	N-Acetylneuraminic Acid	2-13	selectin L	Homo sapiens	89-99
32501471-1	2021	Siglec-15 is a conserved sialic acid-binding Ig-like lectin expressed on osteoclast progenitors that plays an important role in osteoclast development and function.	N-Acetylneuraminic Acid	25-36	sialic acid binding Ig like lectin 15	Homo sapiens	0-9
33397354-2	2021	Siglec-E, a mouse orthologue of human Siglec-9, is a sialic acid binding lectin predominantly expressed on the surface of myeloid cells to transduce inhibitory signal via recruitment of SH2-domain containing protein tyrosine phosphatase SHP-1/2 upon binding to its sialoglycan ligands.	N-Acetylneuraminic Acid	53-64	sialic acid binding Ig-like lectin E	Mus musculus	0-8
33397354-2	2021	Siglec-E, a mouse orthologue of human Siglec-9, is a sialic acid binding lectin predominantly expressed on the surface of myeloid cells to transduce inhibitory signal via recruitment of SH2-domain containing protein tyrosine phosphatase SHP-1/2 upon binding to its sialoglycan ligands.	N-Acetylneuraminic Acid	53-64	sialic acid binding Ig like lectin 9	Homo sapiens	38-46
33397354-2	2021	Siglec-E, a mouse orthologue of human Siglec-9, is a sialic acid binding lectin predominantly expressed on the surface of myeloid cells to transduce inhibitory signal via recruitment of SH2-domain containing protein tyrosine phosphatase SHP-1/2 upon binding to its sialoglycan ligands.	N-Acetylneuraminic Acid	53-64	nuclear receptor subfamily 0 group B member 2	Homo sapiens	237-244
33389218-2	2021	A sialic acid (SA)-modified liposomal (SAL) formulation, based on the high expression of L-selectin in peripheral blood neutrophils (PBNs) and SA as its targeting ligand, has proved to be an effective neutrophil-mediated drug delivery system targeting rheumatoid arthritis (RA).	N-Acetylneuraminic Acid	15-17	selectin L	Homo sapiens	89-99
33827385-3	2021	Neuraminidase generally recognizes the sialic acid glycosidic bonds at the ends of glycoproteins or glycolipids and enzymatically removes sialic acid.	N-Acetylneuraminic Acid	39-50	neuraminidase 1	Homo sapiens	0-13
33827385-3	2021	Neuraminidase generally recognizes the sialic acid glycosidic bonds at the ends of glycoproteins or glycolipids and enzymatically removes sialic acid.	N-Acetylneuraminic Acid	138-149	neuraminidase 1	Homo sapiens	0-13
33908016-3	2021	Sialic acid chemical derivatization can be used to determine the isomeric linkage (alpha2,3 or alpha2,6) of sialic acids attached to N-glycans, while endoglycosidase F3 (Endo F3) can be enzymatically applied to preferentially release alpha1,6-linked core fucosylated glycans, further describing the linkage of fucose on N-glycans.	N-Acetylneuraminic Acid	0-11	immunoglobulin kappa variable 2-24	Homo sapiens	83-91
33248687-0	2021	The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid.	N-Acetylneuraminic Acid	83-94	sialic acid binding Ig like lectin 7	Homo sapiens	63-71
33223341-4	2021	To address the involvement of rare variants in GBS, we analyzed Siglec-10, a sialic acid-recognizing inhibitory receptor expressed on B cells.	N-Acetylneuraminic Acid	77-88	sialic acid binding Ig like lectin 10	Homo sapiens	64-73
33386625-3	2021	In this study, we found that oral sialic acid tended to increase the relative weight of liver and decreased the serum aspartate aminotransferase (GPT) activity.	N-Acetylneuraminic Acid	34-45	glutamic pyruvic transaminase, soluble	Mus musculus	146-149
33177111-2	2021	ST3GAL1 is a sialyltransferase that adds sialic acid to core 1 glycans, thereby terminating glycan chain extension.	N-Acetylneuraminic Acid	41-52	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	0-7
33908016-3	2021	Sialic acid chemical derivatization can be used to determine the isomeric linkage (alpha2,3 or alpha2,6) of sialic acids attached to N-glycans, while endoglycosidase F3 (Endo F3) can be enzymatically applied to preferentially release alpha1,6-linked core fucosylated glycans, further describing the linkage of fucose on N-glycans.	N-Acetylneuraminic Acid	0-11	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	95-103
33351118-6	2020	We found that GPC-derived sialic acid residues suppress activity of both Lutheran/basal cell adhesion molecule (Lu/BCAM) and CD44 by the formation of a complex on the erythrocyte membrane, and Gardos channel-mediated shedding of GPC results in Lu/BCAM and CD44 activation.	N-Acetylneuraminic Acid	26-37	glycophorin C (Gerbich blood group)	Homo sapiens	14-17
33375516-6	2020	We show that NKp46 binds the HA protein of influenza B in a sialic acid-dependent manner, and identified the glycosylated residue in NKp46, which is critical for this interaction.	N-Acetylneuraminic Acid	60-71	natural cytotoxicity triggering receptor 1	Mus musculus	13-18
33375516-6	2020	We show that NKp46 binds the HA protein of influenza B in a sialic acid-dependent manner, and identified the glycosylated residue in NKp46, which is critical for this interaction.	N-Acetylneuraminic Acid	60-71	natural cytotoxicity triggering receptor 1	Mus musculus	133-138
33351118-6	2020	We found that GPC-derived sialic acid residues suppress activity of both Lutheran/basal cell adhesion molecule (Lu/BCAM) and CD44 by the formation of a complex on the erythrocyte membrane, and Gardos channel-mediated shedding of GPC results in Lu/BCAM and CD44 activation.	N-Acetylneuraminic Acid	26-37	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	115-119
33351118-6	2020	We found that GPC-derived sialic acid residues suppress activity of both Lutheran/basal cell adhesion molecule (Lu/BCAM) and CD44 by the formation of a complex on the erythrocyte membrane, and Gardos channel-mediated shedding of GPC results in Lu/BCAM and CD44 activation.	N-Acetylneuraminic Acid	26-37	CD44 molecule (Indian blood group)	Homo sapiens	125-129
33351118-6	2020	We found that GPC-derived sialic acid residues suppress activity of both Lutheran/basal cell adhesion molecule (Lu/BCAM) and CD44 by the formation of a complex on the erythrocyte membrane, and Gardos channel-mediated shedding of GPC results in Lu/BCAM and CD44 activation.	N-Acetylneuraminic Acid	26-37	glycophorin C (Gerbich blood group)	Homo sapiens	229-232
33351118-6	2020	We found that GPC-derived sialic acid residues suppress activity of both Lutheran/basal cell adhesion molecule (Lu/BCAM) and CD44 by the formation of a complex on the erythrocyte membrane, and Gardos channel-mediated shedding of GPC results in Lu/BCAM and CD44 activation.	N-Acetylneuraminic Acid	26-37	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	247-251
33351118-6	2020	We found that GPC-derived sialic acid residues suppress activity of both Lutheran/basal cell adhesion molecule (Lu/BCAM) and CD44 by the formation of a complex on the erythrocyte membrane, and Gardos channel-mediated shedding of GPC results in Lu/BCAM and CD44 activation.	N-Acetylneuraminic Acid	26-37	CD44 molecule (Indian blood group)	Homo sapiens	256-260
33615152-3	2021	Despite the loss of canonical sialic acid binding, Siglec-XII still recruits Shp2 and accelerates tumor growth in a mouse model.	N-Acetylneuraminic Acid	30-41	sialic acid binding Ig like lectin 12	Homo sapiens	51-61
33087464-5	2020	Two of the top candidates identified, cytidine monophosphate N-acetylneuraminic acid synthetase (Cmas) and solute carrier family 35 member A1 (Slc35a1), promote sialic acid expression on the cell surface.	N-Acetylneuraminic Acid	161-172	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	38-95
33087464-5	2020	Two of the top candidates identified, cytidine monophosphate N-acetylneuraminic acid synthetase (Cmas) and solute carrier family 35 member A1 (Slc35a1), promote sialic acid expression on the cell surface.	N-Acetylneuraminic Acid	161-172	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	97-101
33087464-5	2020	Two of the top candidates identified, cytidine monophosphate N-acetylneuraminic acid synthetase (Cmas) and solute carrier family 35 member A1 (Slc35a1), promote sialic acid expression on the cell surface.	N-Acetylneuraminic Acid	161-172	solute carrier family 35 member A1	Homo sapiens	107-141
33087464-5	2020	Two of the top candidates identified, cytidine monophosphate N-acetylneuraminic acid synthetase (Cmas) and solute carrier family 35 member A1 (Slc35a1), promote sialic acid expression on the cell surface.	N-Acetylneuraminic Acid	161-172	solute carrier family 35 member A1	Homo sapiens	143-150
33087464-11	2020	However, exogenous expression of Cmas and Slc35a1 into the respective null cells restored sialic acid expression and T3SA+ binding and infectivity.	N-Acetylneuraminic Acid	90-101	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	33-37
33087464-11	2020	However, exogenous expression of Cmas and Slc35a1 into the respective null cells restored sialic acid expression and T3SA+ binding and infectivity.	N-Acetylneuraminic Acid	90-101	solute carrier family 35 member A1	Homo sapiens	42-49
33087464-12	2020	These results demonstrate that Cmas and Slc35a1, which mediate cell-surface expression of sialic acid, are required in murine microglial cells for efficient reovirus binding and infection.IMPORTANCE Attachment factors and receptors are important determinants of dissemination and tropism during reovirus-induced disease.	N-Acetylneuraminic Acid	90-101	cytidine monophospho-N-acetylneuraminic acid synthetase	Mus musculus	31-35
33087464-12	2020	These results demonstrate that Cmas and Slc35a1, which mediate cell-surface expression of sialic acid, are required in murine microglial cells for efficient reovirus binding and infection.IMPORTANCE Attachment factors and receptors are important determinants of dissemination and tropism during reovirus-induced disease.	N-Acetylneuraminic Acid	90-101	solute carrier family 35 (CMP-sialic acid transporter), member 1	Mus musculus	40-47
33087464-13	2020	In a CRISPR cell-survival screen, we discovered two genes, Cmas and Slc35a1, which encode proteins required for sialic acid expression on the cell surface, that mediate reovirus infection of microglial cells.	N-Acetylneuraminic Acid	112-123	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	59-63
33087464-13	2020	In a CRISPR cell-survival screen, we discovered two genes, Cmas and Slc35a1, which encode proteins required for sialic acid expression on the cell surface, that mediate reovirus infection of microglial cells.	N-Acetylneuraminic Acid	112-123	solute carrier family 35 member A1	Homo sapiens	68-75
33314755-0	2021	Second sialic acid-binding site of influenza A virus neuraminidase: Binding receptors for efficient release.	N-Acetylneuraminic Acid	7-18	neuraminidase 1	Homo sapiens	53-66
33264612-6	2020	Neuraminidase treatment also boosts cross-presentation, suggesting that Leishmania triggers SHP-1-associated sialic-acid-binding receptors.	N-Acetylneuraminic Acid	109-120	neuraminidase 1	Homo sapiens	0-13
33264497-3	2021	Based on notable viral spike (S) protein features, we propose that the flat sialic acid-binding domain at the N-terminal domain (NTD) of the S1 subunit leads to more effective first contact and interaction with the sialic acid layer over the epithelium and this, in turn, allows faster viral "surfing" of the epithelium and receptor scanning by SARS-CoV-2.	N-Acetylneuraminic Acid	76-87	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	23-28
33264497-3	2021	Based on notable viral spike (S) protein features, we propose that the flat sialic acid-binding domain at the N-terminal domain (NTD) of the S1 subunit leads to more effective first contact and interaction with the sialic acid layer over the epithelium and this, in turn, allows faster viral "surfing" of the epithelium and receptor scanning by SARS-CoV-2.	N-Acetylneuraminic Acid	76-87	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	30-31
33264497-3	2021	Based on notable viral spike (S) protein features, we propose that the flat sialic acid-binding domain at the N-terminal domain (NTD) of the S1 subunit leads to more effective first contact and interaction with the sialic acid layer over the epithelium and this, in turn, allows faster viral "surfing" of the epithelium and receptor scanning by SARS-CoV-2.	N-Acetylneuraminic Acid	215-226	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	23-28
33264497-3	2021	Based on notable viral spike (S) protein features, we propose that the flat sialic acid-binding domain at the N-terminal domain (NTD) of the S1 subunit leads to more effective first contact and interaction with the sialic acid layer over the epithelium and this, in turn, allows faster viral "surfing" of the epithelium and receptor scanning by SARS-CoV-2.	N-Acetylneuraminic Acid	215-226	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	30-31
32607676-0	2020	The Effect of Sialic Acid on the Expression of miR-218, NF-kB, MMP-9, and TIMP-1.	N-Acetylneuraminic Acid	14-25	matrix metallopeptidase 9	Homo sapiens	63-68
32607676-0	2020	The Effect of Sialic Acid on the Expression of miR-218, NF-kB, MMP-9, and TIMP-1.	N-Acetylneuraminic Acid	14-25	TIMP metallopeptidase inhibitor 1	Homo sapiens	74-80
32607676-5	2020	In this study, for the first time, we aimed to analyze the possible effect of the sialic acid solution exposure in the human C118 cell line, which was derived from a human brain astrocytoma (glial cells), on the expression patterns of miR-218, NF-kB, MMP-9, and TIMP-1.	N-Acetylneuraminic Acid	82-93	matrix metallopeptidase 9	Homo sapiens	251-256
32607676-5	2020	In this study, for the first time, we aimed to analyze the possible effect of the sialic acid solution exposure in the human C118 cell line, which was derived from a human brain astrocytoma (glial cells), on the expression patterns of miR-218, NF-kB, MMP-9, and TIMP-1.	N-Acetylneuraminic Acid	82-93	TIMP metallopeptidase inhibitor 1	Homo sapiens	262-268
32607676-10	2020	At 300 microM, 500 microM, and 1000 microM sialic acid treatments, the expression of miR-218 was downregulated; subsequently, the NF-kB, MMP-9, and TIMP-1 genes as well as their protein expressions were upregulated.	N-Acetylneuraminic Acid	43-54	matrix metallopeptidase 9	Homo sapiens	137-142
32607676-10	2020	At 300 microM, 500 microM, and 1000 microM sialic acid treatments, the expression of miR-218 was downregulated; subsequently, the NF-kB, MMP-9, and TIMP-1 genes as well as their protein expressions were upregulated.	N-Acetylneuraminic Acid	43-54	TIMP metallopeptidase inhibitor 1	Homo sapiens	148-154
32607676-12	2020	This study could demonstrate the significant effect of sialic acid on miR-218, NF-kB, MMP-9 , and TIMP-1 expressions in gene and protein levels and also the levels of enzyme activity of secreted MMP-9.	N-Acetylneuraminic Acid	55-66	matrix metallopeptidase 9	Homo sapiens	86-91
32607676-12	2020	This study could demonstrate the significant effect of sialic acid on miR-218, NF-kB, MMP-9 , and TIMP-1 expressions in gene and protein levels and also the levels of enzyme activity of secreted MMP-9.	N-Acetylneuraminic Acid	55-66	TIMP metallopeptidase inhibitor 1	Homo sapiens	98-104
32607676-12	2020	This study could demonstrate the significant effect of sialic acid on miR-218, NF-kB, MMP-9 , and TIMP-1 expressions in gene and protein levels and also the levels of enzyme activity of secreted MMP-9.	N-Acetylneuraminic Acid	55-66	matrix metallopeptidase 9	Homo sapiens	195-200
33264612-6	2020	Neuraminidase treatment also boosts cross-presentation, suggesting that Leishmania triggers SHP-1-associated sialic-acid-binding receptors.	N-Acetylneuraminic Acid	109-120	nuclear receptor subfamily 0 group B member 2	Homo sapiens	92-97
33020147-1	2020	Siglec-15 is a conserved sialic acid-binding Ig-like lectin, which is expressed on osteoclasts.	N-Acetylneuraminic Acid	25-36	sialic acid binding Ig-like lectin 15	Mus musculus	0-9
32921414-5	2020	The six amino acid residues and two sialic acid residues are directly associated with four complementarity-determining regions (CDRs; H1, H2, H3, and L3) and four CDRs (H2, H3, L1, and L3), respectively.	N-Acetylneuraminic Acid	36-47	relaxin 2	Homo sapiens	163-175
33289969-6	2020	Siglec-F overexpression activates an endocytic and pyroptotic inflammatory response in BV-2 cells, dependent on its sialic acid substrates and immunoreceptor tyrosine-based inhibition motif (ITIM) phosphorylation sites.	N-Acetylneuraminic Acid	116-127	sialic acid binding Ig-like lectin F	Mus musculus	0-8
33130469-1	2020	N-acetylneuraminic acid synthase (NANS), the gene encoding the synthase for N-acetylneuraminic acid (NeuNAc; sialic acid), is closely associated with infantile-onset severe developmental delay and skeletal dysplasia.	N-Acetylneuraminic Acid	0-23	N-acetylneuraminate synthase	Homo sapiens	34-38
33130469-1	2020	N-acetylneuraminic acid synthase (NANS), the gene encoding the synthase for N-acetylneuraminic acid (NeuNAc; sialic acid), is closely associated with infantile-onset severe developmental delay and skeletal dysplasia.	N-Acetylneuraminic Acid	101-107	N-acetylneuraminate synthase	Homo sapiens	0-32
33130469-1	2020	N-acetylneuraminic acid synthase (NANS), the gene encoding the synthase for N-acetylneuraminic acid (NeuNAc; sialic acid), is closely associated with infantile-onset severe developmental delay and skeletal dysplasia.	N-Acetylneuraminic Acid	101-107	N-acetylneuraminate synthase	Homo sapiens	34-38
33130469-1	2020	N-acetylneuraminic acid synthase (NANS), the gene encoding the synthase for N-acetylneuraminic acid (NeuNAc; sialic acid), is closely associated with infantile-onset severe developmental delay and skeletal dysplasia.	N-Acetylneuraminic Acid	109-120	N-acetylneuraminate synthase	Homo sapiens	0-32
33130469-1	2020	N-acetylneuraminic acid synthase (NANS), the gene encoding the synthase for N-acetylneuraminic acid (NeuNAc; sialic acid), is closely associated with infantile-onset severe developmental delay and skeletal dysplasia.	N-Acetylneuraminic Acid	109-120	N-acetylneuraminate synthase	Homo sapiens	34-38
33202622-1	2020	Polysialic acid (polySia/PSA) is a linear homopolymer of sialic acid (Sia) that primarily modifies the neural cell adhesion molecule (NCAM) in mammalian brains.	N-Acetylneuraminic Acid	4-15	neural cell adhesion molecule 1	Homo sapiens	103-132
33202622-1	2020	Polysialic acid (polySia/PSA) is a linear homopolymer of sialic acid (Sia) that primarily modifies the neural cell adhesion molecule (NCAM) in mammalian brains.	N-Acetylneuraminic Acid	4-15	neural cell adhesion molecule 1	Homo sapiens	134-138
33200130-2	2021	Neuraminidase-mediated cleavage of surface sialic acid has been demonstrated to regulate leukocyte responses.	N-Acetylneuraminic Acid	43-54	neuraminidase 1	Homo sapiens	0-13
33200130-3	2021	Here, we report that antiviral neuraminidase inhibitors constrain host neuraminidase activity, surface sialic acid release, ROS production, and NETs released by microbial-activated human neutrophils.	N-Acetylneuraminic Acid	103-114	neuraminidase 1	Homo sapiens	31-44
33210034-9	2021	In vitro and in vivo studies revealed that SA-MPDA@SPIO/DOX/Fe3+ NPs could effectively target to the hepatic tumor tissue, which was possibly due to the specific interaction between SA and the overexpressed E-selectin.	N-Acetylneuraminic Acid	43-45	selectin E	Homo sapiens	207-217
33182731-5	2020	Further, utilizing enhanced intact glycopeptide identification afforded by the NGAG workflow, we found that the sugar analog 1,3,4-O-Bu3ManNAc, a "high flux" metabolic precursor for sialic acid biosynthesis, increased sialylation of secreted proteins including recombinant human erythropoietin (rhEPO).	N-Acetylneuraminic Acid	182-193	erythropoietin	Homo sapiens	279-293
32911203-2	2020	Few reports have investigated the specificity of human neuraminidase (hNEU) activity towards modified sialic acid residues that can occur on glycoproteins.	N-Acetylneuraminic Acid	102-113	neuraminidase 1	Homo sapiens	55-68
33154460-2	2020	Gc1 contains an O-linked trisaccharide [sialic acid-galactose-N-acetylgalactosamine (GalNAc)] on the threonine420 (Thr420) residue and can be converted to a potent macrophage activating factor (GcMAF) by selective removal of sialic acid and galactose, leaving GalNAc at Thr420.	N-Acetylneuraminic Acid	40-51	solute carrier family 25 member 22	Homo sapiens	0-3
33154460-2	2020	Gc1 contains an O-linked trisaccharide [sialic acid-galactose-N-acetylgalactosamine (GalNAc)] on the threonine420 (Thr420) residue and can be converted to a potent macrophage activating factor (GcMAF) by selective removal of sialic acid and galactose, leaving GalNAc at Thr420.	N-Acetylneuraminic Acid	40-51	GC vitamin D binding protein	Homo sapiens	194-199
33154460-2	2020	Gc1 contains an O-linked trisaccharide [sialic acid-galactose-N-acetylgalactosamine (GalNAc)] on the threonine420 (Thr420) residue and can be converted to a potent macrophage activating factor (GcMAF) by selective removal of sialic acid and galactose, leaving GalNAc at Thr420.	N-Acetylneuraminic Acid	225-236	solute carrier family 25 member 22	Homo sapiens	0-3
33090801-2	2020	However, this barrier is constantly challenged by mucin-degrading enzymes, which tend to target anionic glycan chains such as sulfate groups and sialic acid residues.	N-Acetylneuraminic Acid	145-156	LOC100508689	Homo sapiens	50-55
32911203-2	2020	Few reports have investigated the specificity of human neuraminidase (hNEU) activity towards modified sialic acid residues that can occur on glycoproteins.	N-Acetylneuraminic Acid	102-113	neuraminidase 1	Homo sapiens	70-74
32911203-3	2020	Previously, we evaluated hNEU activity towards 9-O-acetylated sialic acid in glycolipid substrates and found that hNEU generally discriminated against 9-O-acetylated sialic acid over Neu5Ac.	N-Acetylneuraminic Acid	62-73	neuraminidase 1	Homo sapiens	25-29
32911203-3	2020	Previously, we evaluated hNEU activity towards 9-O-acetylated sialic acid in glycolipid substrates and found that hNEU generally discriminated against 9-O-acetylated sialic acid over Neu5Ac.	N-Acetylneuraminic Acid	62-73	neuraminidase 1	Homo sapiens	114-118
32911203-3	2020	Previously, we evaluated hNEU activity towards 9-O-acetylated sialic acid in glycolipid substrates and found that hNEU generally discriminated against 9-O-acetylated sialic acid over Neu5Ac.	N-Acetylneuraminic Acid	166-177	neuraminidase 1	Homo sapiens	25-29
32911203-3	2020	Previously, we evaluated hNEU activity towards 9-O-acetylated sialic acid in glycolipid substrates and found that hNEU generally discriminated against 9-O-acetylated sialic acid over Neu5Ac.	N-Acetylneuraminic Acid	166-177	neuraminidase 1	Homo sapiens	114-118
32911203-3	2020	Previously, we evaluated hNEU activity towards 9-O-acetylated sialic acid in glycolipid substrates and found that hNEU generally discriminated against 9-O-acetylated sialic acid over Neu5Ac.	N-Acetylneuraminic Acid	183-189	neuraminidase 1	Homo sapiens	25-29
32911203-3	2020	Previously, we evaluated hNEU activity towards 9-O-acetylated sialic acid in glycolipid substrates and found that hNEU generally discriminated against 9-O-acetylated sialic acid over Neu5Ac.	N-Acetylneuraminic Acid	183-189	neuraminidase 1	Homo sapiens	114-118
32856413-2	2020	A new drug candidate under clinical investigation to treat brain diseases is Neuro-EPO, produced by selecting EPO isoforms with low sialic acid content.	N-Acetylneuraminic Acid	132-143	erythropoietin	Rattus norvegicus	83-86
32856413-2	2020	A new drug candidate under clinical investigation to treat brain diseases is Neuro-EPO, produced by selecting EPO isoforms with low sialic acid content.	N-Acetylneuraminic Acid	132-143	erythropoietin	Rattus norvegicus	110-113
32971853-9	2020	Interestingly, predominant glycoforms associated with acetylneuraminic acid were obviously detected in alpha-2 macroglobulin, haptoglobin, alpha-1-acid glycoprotein 1, and complement C4-A of CRC patient groups.	N-Acetylneuraminic Acid	54-75	alpha-2-macroglobulin	Homo sapiens	103-124
33010330-9	2020	In addition, the opposite alterations of the afucosylated glycans with alpha2,3-linked sialic acid and those only with alpha2,6-linked sialic acid were observed at old age in male mice.	N-Acetylneuraminic Acid	87-98	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	71-79
33010330-9	2020	In addition, the opposite alterations of the afucosylated glycans with alpha2,3-linked sialic acid and those only with alpha2,6-linked sialic acid were observed at old age in male mice.	N-Acetylneuraminic Acid	135-146	calmegin	Mus musculus	119-127
32279315-9	2020	Siglec-E was found to bind to TLR4 via sialic acid residues and inhibit IL-6 release by BV-2 cells.	N-Acetylneuraminic Acid	39-50	sialic acid binding Ig-like lectin E	Mus musculus	0-8
32279315-9	2020	Siglec-E was found to bind to TLR4 via sialic acid residues and inhibit IL-6 release by BV-2 cells.	N-Acetylneuraminic Acid	39-50	toll-like receptor 4	Mus musculus	30-34
33106801-6	2020	The spike and ACE2 proteins are highly glycosylated with sialic acid modifications that direct viral-host interactions and infection.	N-Acetylneuraminic Acid	57-68	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	4-9
33106801-6	2020	The spike and ACE2 proteins are highly glycosylated with sialic acid modifications that direct viral-host interactions and infection.	N-Acetylneuraminic Acid	57-68	angiotensin converting enzyme 2	Homo sapiens	14-18
32669363-4	2020	Using 1D and 2D nuclear magnetic resonance (NMR), we elucidated the multistep enzymatic mechanism of the oxidoreductase (RgNanOx) that leads to the reversible conversion of 2,7-anhydro-Neu5Ac to Neu5Ac through formation of a 4-keto-DANA intermediate and NAD+ regeneration.	N-Acetylneuraminic Acid	185-191	oxidoreductase	Escherichia coli	105-119
32351126-2	2020	Sialic acid-binding immunoglobulin-like lectin 1 (siglec1 or CD169), mainly expressed in macrophages and dendritic cells, is markedly upregulated after encountering pathogens or under acute/chronic inflammation conditions.	N-Acetylneuraminic Acid	0-11	sialic acid binding Ig like lectin 1	Rattus norvegicus	50-57
32971290-3	2020	ST6Gal I is a sialyltransferase using activated CMP-sialic acids as donor substrates to catalyze the formation of a alpha2,6-glycosidic bond between the sialic acid residue and the acceptor disaccharide LacNAc.	N-Acetylneuraminic Acid	52-63	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	0-8
33254482-4	2020	S1 is subdivided in domains S1A (or NTD) and S1B (or RBD), with experimental and in silico studies suggesting that the former binds to sialic acid-containing glycoproteins, such as CD147, whereas the latter binds to ACE2 receptor.	N-Acetylneuraminic Acid	135-146	basigin (Ok blood group)	Homo sapiens	181-186
33254482-7	2020	Based on this survey, we hypothesize that the correlation between the ABO blood system and susceptibility to SARS-CoV-2 infection can be presumably explained by the modulation of sialic acid-containing receptors distribution on host cell surface induced by ABO antigens through carbohydrate-carbohydrate interactions, which could maximize or minimize the virus Spike protein binding to the host cell.	N-Acetylneuraminic Acid	179-190	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	70-73
33254482-7	2020	Based on this survey, we hypothesize that the correlation between the ABO blood system and susceptibility to SARS-CoV-2 infection can be presumably explained by the modulation of sialic acid-containing receptors distribution on host cell surface induced by ABO antigens through carbohydrate-carbohydrate interactions, which could maximize or minimize the virus Spike protein binding to the host cell.	N-Acetylneuraminic Acid	179-190	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	257-260
33254482-7	2020	Based on this survey, we hypothesize that the correlation between the ABO blood system and susceptibility to SARS-CoV-2 infection can be presumably explained by the modulation of sialic acid-containing receptors distribution on host cell surface induced by ABO antigens through carbohydrate-carbohydrate interactions, which could maximize or minimize the virus Spike protein binding to the host cell.	N-Acetylneuraminic Acid	179-190	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	361-366
33076454-8	2020	Defects in proteins involved in Golgi trafficking (COG5-CDG) and CMP-sialic acid transport (SLC35A1-CDG) resulted in lower levels of sialylated structures on plasma proteins as compared to healthy controls.	N-Acetylneuraminic Acid	69-80	solute carrier family 35 member A1	Homo sapiens	92-99
32803224-2	2020	CD33 (Siglec-3) is a transmembrane sialic acid-binding receptor on the surface of microglial cells.	N-Acetylneuraminic Acid	35-46	CD33 antigen	Mus musculus	0-4
32803224-2	2020	CD33 (Siglec-3) is a transmembrane sialic acid-binding receptor on the surface of microglial cells.	N-Acetylneuraminic Acid	35-46	CD33 antigen	Mus musculus	6-14
32699083-4	2020	While sialic acid binding is specific for alpha2-3-linked sialic acid and mediated by the exposed apical loops of the major capsid protein VP1, a broad range of GAG oligosaccharides bind to recessed regions between VP1 capsomers.	N-Acetylneuraminic Acid	6-17	immunoglobulin kappa variable 2-24	Homo sapiens	42-50
32699083-4	2020	While sialic acid binding is specific for alpha2-3-linked sialic acid and mediated by the exposed apical loops of the major capsid protein VP1, a broad range of GAG oligosaccharides bind to recessed regions between VP1 capsomers.	N-Acetylneuraminic Acid	58-69	immunoglobulin kappa variable 2-24	Homo sapiens	42-50
32971853-9	2020	Interestingly, predominant glycoforms associated with acetylneuraminic acid were obviously detected in alpha-2 macroglobulin, haptoglobin, alpha-1-acid glycoprotein 1, and complement C4-A of CRC patient groups.	N-Acetylneuraminic Acid	54-75	orosomucoid 1	Homo sapiens	139-166
32971853-9	2020	Interestingly, predominant glycoforms associated with acetylneuraminic acid were obviously detected in alpha-2 macroglobulin, haptoglobin, alpha-1-acid glycoprotein 1, and complement C4-A of CRC patient groups.	N-Acetylneuraminic Acid	54-75	complement C4A (Rodgers blood group)	Homo sapiens	172-187
32830957-3	2020	Here we report a highly efficient method for the identification of O-GlcNAc modification via tandem glycan labeling, in which O-GlcNAc is first galactosylated and then sialylated with a fluorophore-conjugated sialic acid residue, therefore enabling highly sensitive fluorescent detection.	N-Acetylneuraminic Acid	209-220	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	67-75
32830957-3	2020	Here we report a highly efficient method for the identification of O-GlcNAc modification via tandem glycan labeling, in which O-GlcNAc is first galactosylated and then sialylated with a fluorophore-conjugated sialic acid residue, therefore enabling highly sensitive fluorescent detection.	N-Acetylneuraminic Acid	209-220	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	126-134
32912159-9	2020	The circulating Neu5Ac level was significantly higher in patients with MI (median [1QR]: 297[220, 374] ng/ml) than in those with UAP (227 [114, 312] ng/ml) or without CAD (207 [114, 276] ng/ml; both p < 0.001).	N-Acetylneuraminic Acid	16-22	ubiquitin associated protein 1	Homo sapiens	129-132
32947893-2	2020	It degrades the sialic acid contained in extracellular mucin.	N-Acetylneuraminic Acid	16-27	LOC100508689	Homo sapiens	55-60
32867495-3	2020	A BA-end-functionalized poly(ethylene glycol) was decorated onto an atomic force microscopy (AFM) cantilever, which provided a dynamic and sialic acid (SA)-specific imaging mode.	N-Acetylneuraminic Acid	139-150	acyl-CoA synthetase medium chain family member 3	Homo sapiens	152-154
32853241-0	2020	Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin.	N-Acetylneuraminic Acid	23-34	neuraminidase 1	Homo sapiens	69-82
33082935-6	2020	Finally, a key domain in the spike protein of SARS-CoV2 has been shown to bind N-acetylneuraminic acid (Neu5Ac), a process that may be essential to cell entry by the virus.	N-Acetylneuraminic Acid	79-102	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	29-34
33082935-6	2020	Finally, a key domain in the spike protein of SARS-CoV2 has been shown to bind N-acetylneuraminic acid (Neu5Ac), a process that may be essential to cell entry by the virus.	N-Acetylneuraminic Acid	104-110	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	29-34
33082935-7	2020	This Neu5Ac-binding domain shares striking morphological, sequence, and functional similarities with human Gal-3.	N-Acetylneuraminic Acid	5-11	galectin 3	Homo sapiens	107-112
32865821-2	2020	This conversion is an essential step in the catabolism of sialic acid in several pathogenic bacteria, including Pasteurella multocida, and thus NagA is identified as a potential drug target.	N-Acetylneuraminic Acid	58-69	N-acetylglucosamine-6-phosphate deacetylase	Pasteurella multocida	144-148
32929335-6	2020	Among them, ST3GAL6, a glycotransferase to transfer sialic acid to 3"-hydroxyl group of a galactose residue, showed a significant negative association with the subtype with luminal feature in UBC patients (n=2,130 in total).	N-Acetylneuraminic Acid	52-63	ST3 beta-galactoside alpha-2,3-sialyltransferase 6	Homo sapiens	12-19
32686823-4	2020	The results revealed that the zebrafish Neu1 desialyzed both a2-3 and a2-6 sialic acid linkages from oligosaccharides and glycoproteins at pH 4.5, and it is highly conserved with other fish species and mammalian Neu1.	N-Acetylneuraminic Acid	75-86	neuraminidase 1	Danio rerio	40-44
32608236-0	2020	Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin.	N-Acetylneuraminic Acid	104-115	solute carrier family 17 member 5	Homo sapiens	128-134
32608236-1	2020	Sialin, encoded by the SLC17A5 gene, is a lysosomal sialic acid transporter defective in Salla disease, a rare inherited leukodystrophy.	N-Acetylneuraminic Acid	52-63	solute carrier family 17 member 5	Homo sapiens	0-6
32608236-1	2020	Sialin, encoded by the SLC17A5 gene, is a lysosomal sialic acid transporter defective in Salla disease, a rare inherited leukodystrophy.	N-Acetylneuraminic Acid	52-63	solute carrier family 17 member 5	Homo sapiens	23-30
32883391-0	2020	Production of sialic acid rich glycopeptide from bovine kappa-casein glycomacropeptide by hydrolyzing with papain.	N-Acetylneuraminic Acid	14-25	casein kappa	Bos taurus	56-68
32849600-8	2020	Given the shortage of well-described long spacer domains with a favorable functionality profile, we designed a novel class of CAR spacers with similar attributes to IgG spacers but without unspecific off-target binding, derived from the Sialic acid-binding immunoglobulin-type lectins (Siglecs).	N-Acetylneuraminic Acid	237-248	nuclear receptor subfamily 1, group I, member 3	Mus musculus	126-129
32752208-1	2020	Background: Sialidosis is a rare autosomal recessive disease caused by NEU1 mutations, leading to neuraminidase deficiency and accumulation of sialic acid-containing oligosaccharides and glycopeptides into the tissues.	N-Acetylneuraminic Acid	143-154	neuraminidase 1	Homo sapiens	71-75
32824359-1	2020	Polysialic acid (polySia/PSA) is an anionic glycan polymer of sialic acid, and it mostly modifies the neural cell adhesion molecule (NCAM) in mammalian brains.	N-Acetylneuraminic Acid	4-15	neural cell adhesion molecule 1	Homo sapiens	102-131
32824359-1	2020	Polysialic acid (polySia/PSA) is an anionic glycan polymer of sialic acid, and it mostly modifies the neural cell adhesion molecule (NCAM) in mammalian brains.	N-Acetylneuraminic Acid	4-15	neural cell adhesion molecule 1	Homo sapiens	133-137
32723915-4	2020	In order to define their receptor engagement strategies, we first used nuclear magnetic resonance (NMR) spectroscopy to establish that the major capsid proteins (VP1) of both viruses bind to sialic acid in solution.	N-Acetylneuraminic Acid	191-202	VP1	Human polyomavirus 12	162-165
32736841-2	2020	Although GNE, which is the mutated gene in the disease, is well known as the key enzyme in the biosynthesis pathway of sialic acid, the pathophysiological pathway leading from GNE mutations to the muscle phenotype in GNE Myopathy is still unclear.	N-Acetylneuraminic Acid	119-130	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	9-12
32752058-4	2020	Sialic acid residues on the neural cell surfaces inhibit complement and microglial activation, as well as phagocytosis of the underlying structures, via binding to (i) complement factor H (CFH) or (ii) sialic acid-binding immunoglobulin-like lectin (SIGLEC) receptors.	N-Acetylneuraminic Acid	0-11	complement factor H	Homo sapiens	168-187
32752058-4	2020	Sialic acid residues on the neural cell surfaces inhibit complement and microglial activation, as well as phagocytosis of the underlying structures, via binding to (i) complement factor H (CFH) or (ii) sialic acid-binding immunoglobulin-like lectin (SIGLEC) receptors.	N-Acetylneuraminic Acid	0-11	complement factor H	Homo sapiens	189-192
32722157-9	2020	In non-secretors, third trimester fasting plasma glucose and insulin were negatively associated with total HMO-bound sialic acid and concentrations of the sialylated HMOs 3"-sialyllactose and disialylacto-N-tetraose.	N-Acetylneuraminic Acid	117-128	insulin	Homo sapiens	61-68
32639985-5	2020	However, how IAV"s binding to sialic acid leads to engagement and activation of EGFR remains largely unclear.	N-Acetylneuraminic Acid	30-41	epidermal growth factor receptor	Homo sapiens	80-84
32513821-8	2020	Siglec-7 mediated the binding and biological actions of GdA in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	65-76	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
32513821-8	2020	Siglec-7 mediated the binding and biological actions of GdA in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	65-76	progestagen associated endometrial protein	Homo sapiens	56-59
32665690-8	2020	Such possibility relies upon a putative role in sialic acid biology, where GBA3 participates in a cellular network involving NEU2 and CMAH.	N-Acetylneuraminic Acid	48-59	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	75-79
32665690-8	2020	Such possibility relies upon a putative role in sialic acid biology, where GBA3 participates in a cellular network involving NEU2 and CMAH.	N-Acetylneuraminic Acid	48-59	neuraminidase 2	Homo sapiens	125-129
32664459-1	2020	N-glycolylneuraminic acid (NeuGc), a non-human sialic acid derivative synthesized by cytidine-5"-monophospho-N-acetylneuraminic acid hydroxylase (CMAH), plays a crucial role in mediating infections by certain pathogens.	N-Acetylneuraminic Acid	47-58	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	85-144
32664459-1	2020	N-glycolylneuraminic acid (NeuGc), a non-human sialic acid derivative synthesized by cytidine-5"-monophospho-N-acetylneuraminic acid hydroxylase (CMAH), plays a crucial role in mediating infections by certain pathogens.	N-Acetylneuraminic Acid	47-58	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	146-150
32142289-5	2020	Therefore, in this proof-of-principle study, we have evaluated the use of hydrophilic interaction liquid chromatography (HILIC) in combination with targeted quantitative mass spectrometry for the sialic acid linkage-specific analysis of PSA glyco-proteoforms based on either trypsin or ArgC peptides.	N-Acetylneuraminic Acid	196-207	kallikrein related peptidase 3	Homo sapiens	237-240
32664106-7	2020	The levels of the GNE gene were measured, which encodes UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE), a key enzyme in SA biosynthesis.	N-Acetylneuraminic Acid	116-118	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	18-21
32664106-7	2020	The levels of the GNE gene were measured, which encodes UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE), a key enzyme in SA biosynthesis.	N-Acetylneuraminic Acid	116-118	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	56-92
32664106-7	2020	The levels of the GNE gene were measured, which encodes UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE), a key enzyme in SA biosynthesis.	N-Acetylneuraminic Acid	116-118	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	94-97
32501643-9	2020	The glycan sequence N-acetylgalactosamine, galactose, and sialic acid was consistently expressed on serine 94, threonine 194, and threonine 289 of APOE in L5 and was predicted to contribute to L5"s negative surface charge and hydrophilicity.	N-Acetylneuraminic Acid	58-69	apolipoprotein E	Homo sapiens	147-151
32775903-2	2020	As cell sugar sorting enables exogenous sugars to be delivered into predetermined subcellular locations, we synthesized sialic acid (Sia) derivatives with rhodamine-X conjugated at C-9 (ROXSia), which hitchhikes cell sialic acid sorting to target tumor cell lysosomes, exhibiting pH-independent long-term probe retention in lysosomes.	N-Acetylneuraminic Acid	120-131	complement component 9	Mus musculus	181-184
32775903-2	2020	As cell sugar sorting enables exogenous sugars to be delivered into predetermined subcellular locations, we synthesized sialic acid (Sia) derivatives with rhodamine-X conjugated at C-9 (ROXSia), which hitchhikes cell sialic acid sorting to target tumor cell lysosomes, exhibiting pH-independent long-term probe retention in lysosomes.	N-Acetylneuraminic Acid	217-228	complement component 9	Mus musculus	181-184
32501643-10	2020	The electrostatic force between the negatively charged sialic acid-containing glycan residue of APOE and positively charged amino acids at the receptor-binding area suggested that glycosylation interferes with APOE"s attraction to receptors, lipid-binding ability, and lipid transportation and metabolism functions.	N-Acetylneuraminic Acid	55-66	apolipoprotein E	Homo sapiens	96-100
32439590-8	2020	Co-transfection experiment in vitro revealed Gm20319 and miR-7240-5p could indirectly regulate sialic acid level by directly modulating GNE expression, thereby also influencing the expression of SOD1 and IL-1beta.	N-Acetylneuraminic Acid	95-106	predicted gene, 20319	Mus musculus	45-52
32439590-8	2020	Co-transfection experiment in vitro revealed Gm20319 and miR-7240-5p could indirectly regulate sialic acid level by directly modulating GNE expression, thereby also influencing the expression of SOD1 and IL-1beta.	N-Acetylneuraminic Acid	95-106	microRNA 7240	Mus musculus	57-65
32501643-10	2020	The electrostatic force between the negatively charged sialic acid-containing glycan residue of APOE and positively charged amino acids at the receptor-binding area suggested that glycosylation interferes with APOE"s attraction to receptors, lipid-binding ability, and lipid transportation and metabolism functions.	N-Acetylneuraminic Acid	55-66	apolipoprotein E	Homo sapiens	210-214
32439590-8	2020	Co-transfection experiment in vitro revealed Gm20319 and miR-7240-5p could indirectly regulate sialic acid level by directly modulating GNE expression, thereby also influencing the expression of SOD1 and IL-1beta.	N-Acetylneuraminic Acid	95-106	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	136-139
32439590-8	2020	Co-transfection experiment in vitro revealed Gm20319 and miR-7240-5p could indirectly regulate sialic acid level by directly modulating GNE expression, thereby also influencing the expression of SOD1 and IL-1beta.	N-Acetylneuraminic Acid	95-106	interleukin 1 alpha	Mus musculus	204-212
32439590-9	2020	This study revealed Gm20319-miR-7240-5p-GNE network reduced sialic acid level to influence the expression of SOD1 and IL-1beta in liver, which might involve in liver damage induced by DON.	N-Acetylneuraminic Acid	60-71	predicted gene, 20319	Mus musculus	20-27
32439590-9	2020	This study revealed Gm20319-miR-7240-5p-GNE network reduced sialic acid level to influence the expression of SOD1 and IL-1beta in liver, which might involve in liver damage induced by DON.	N-Acetylneuraminic Acid	60-71	microRNA 7240	Mus musculus	28-36
32439590-9	2020	This study revealed Gm20319-miR-7240-5p-GNE network reduced sialic acid level to influence the expression of SOD1 and IL-1beta in liver, which might involve in liver damage induced by DON.	N-Acetylneuraminic Acid	60-71	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	40-43
32439590-9	2020	This study revealed Gm20319-miR-7240-5p-GNE network reduced sialic acid level to influence the expression of SOD1 and IL-1beta in liver, which might involve in liver damage induced by DON.	N-Acetylneuraminic Acid	60-71	superoxide dismutase 1, soluble	Mus musculus	109-113
32439590-9	2020	This study revealed Gm20319-miR-7240-5p-GNE network reduced sialic acid level to influence the expression of SOD1 and IL-1beta in liver, which might involve in liver damage induced by DON.	N-Acetylneuraminic Acid	60-71	interleukin 1 alpha	Mus musculus	118-126
32556248-1	2020	Human-specific pseudogenization of the CMAH gene eliminated the mammalian sialic acid (Sia) Neu5Gc (generating an excess of its precursor Neu5Ac), thus changing ubiquitous cell surface "self-associated molecular patterns" (SAMPs) that modulate innate immunity via engagement of CD33-related-Siglec receptors.	N-Acetylneuraminic Acid	74-85	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	39-43
32556248-1	2020	Human-specific pseudogenization of the CMAH gene eliminated the mammalian sialic acid (Sia) Neu5Gc (generating an excess of its precursor Neu5Ac), thus changing ubiquitous cell surface "self-associated molecular patterns" (SAMPs) that modulate innate immunity via engagement of CD33-related-Siglec receptors.	N-Acetylneuraminic Acid	138-144	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	39-43
32556248-3	2020	The mutation likely altered human SAMPs, triggering multiple events, including emergence of human-adapted pathogens with strong preference for Neu5Ac recognition and/or presenting Neu5Ac-containing molecular mimics of human glycans, which can suppress immune responses via CD33-related-Siglec engagement.	N-Acetylneuraminic Acid	143-149	CD33 molecule	Homo sapiens	273-277
32485644-2	2020	The disease is caused by deficiency of the sialic acid-cleaving enzyme, sialidase 1 or neuraminidase 1 (NEU1).	N-Acetylneuraminic Acid	43-54	neuraminidase 1	Homo sapiens	72-83
32556248-3	2020	The mutation likely altered human SAMPs, triggering multiple events, including emergence of human-adapted pathogens with strong preference for Neu5Ac recognition and/or presenting Neu5Ac-containing molecular mimics of human glycans, which can suppress immune responses via CD33-related-Siglec engagement.	N-Acetylneuraminic Acid	180-186	CD33 molecule	Homo sapiens	273-277
32485644-2	2020	The disease is caused by deficiency of the sialic acid-cleaving enzyme, sialidase 1 or neuraminidase 1 (NEU1).	N-Acetylneuraminic Acid	43-54	neuraminidase 1	Homo sapiens	87-102
32485644-2	2020	The disease is caused by deficiency of the sialic acid-cleaving enzyme, sialidase 1 or neuraminidase 1 (NEU1).	N-Acetylneuraminic Acid	43-54	neuraminidase 1	Homo sapiens	104-108
32406685-4	2020	A set of insulin analogues site-specifically derivatized with sialic acid were prepared in overall yield of 50-60%.	N-Acetylneuraminic Acid	62-73	insulin	Homo sapiens	9-16
32184168-2	2020	Neu1 sialidase is the enzyme responsible for the removal of sialic acid in the mammalian lysosome.	N-Acetylneuraminic Acid	60-71	neuraminidase 1	Homo sapiens	0-4
32321762-0	2020	alpha2, 3-linkage of sialic acid to a GPI-anchor and an unpredicted GPI attachment site in human prion protein.	N-Acetylneuraminic Acid	21-32	glycoprotein hormone subunit alpha 2	Homo sapiens	0-6
32125558-3	2020	Taking these findings together, we aimed to establish CHO cell lines that highly produce sialic acid terminals by overexpressing two N-acetylneuraminic acid-based key enzymes, alpha(2,6)-sialyltransferase and UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase using dihydrofolate reductase/methotrexate gene amplification method.	N-Acetylneuraminic Acid	89-100	beta-galactoside alpha-2,6-sialyltransferase 1	Cricetulus griseus	176-204
32125558-3	2020	Taking these findings together, we aimed to establish CHO cell lines that highly produce sialic acid terminals by overexpressing two N-acetylneuraminic acid-based key enzymes, alpha(2,6)-sialyltransferase and UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase using dihydrofolate reductase/methotrexate gene amplification method.	N-Acetylneuraminic Acid	133-156	beta-galactoside alpha-2,6-sialyltransferase 1	Cricetulus griseus	176-204
32321762-2	2020	The glycosylphosphatidylinositol (GPI) anchor of PrPC is involved in prion disease pathogenesis, and especially sialic acid in a GPI side-chain reportedly affects the PrPC conversion.	N-Acetylneuraminic Acid	112-123	prion protein	Homo sapiens	49-53
32321762-2	2020	The glycosylphosphatidylinositol (GPI) anchor of PrPC is involved in prion disease pathogenesis, and especially sialic acid in a GPI side-chain reportedly affects the PrPC conversion.	N-Acetylneuraminic Acid	112-123	prion protein	Homo sapiens	167-171
32321762-3	2020	Thus, it is important to define the location and structure of the GPI anchor in human PrPC Moreover, the sialic acid linkage-type in the GPI side-chain has not been determined for any GPI-anchored protein.	N-Acetylneuraminic Acid	105-116	prion protein	Homo sapiens	86-90
32321762-7	2020	Using a sialic acid linkage-specific alkylamidation (SALSA) method to discriminate alpha2,3-linkage from alpha2,6-linkage, we found that N-acetylneuraminic acid in PrPC"s GPI side-chain is linked to galactose through an alpha2,3-linkage.	N-Acetylneuraminic Acid	8-19	prion protein	Mus musculus	164-168
32321762-7	2020	Using a sialic acid linkage-specific alkylamidation (SALSA) method to discriminate alpha2,3-linkage from alpha2,6-linkage, we found that N-acetylneuraminic acid in PrPC"s GPI side-chain is linked to galactose through an alpha2,3-linkage.	N-Acetylneuraminic Acid	137-160	glycoprotein hormone subunit alpha 2	Homo sapiens	83-89
32321762-7	2020	Using a sialic acid linkage-specific alkylamidation (SALSA) method to discriminate alpha2,3-linkage from alpha2,6-linkage, we found that N-acetylneuraminic acid in PrPC"s GPI side-chain is linked to galactose through an alpha2,3-linkage.	N-Acetylneuraminic Acid	137-160	glycoprotein hormone subunit alpha 2	Homo sapiens	105-111
32321762-7	2020	Using a sialic acid linkage-specific alkylamidation (SALSA) method to discriminate alpha2,3-linkage from alpha2,6-linkage, we found that N-acetylneuraminic acid in PrPC"s GPI side-chain is linked to galactose through an alpha2,3-linkage.	N-Acetylneuraminic Acid	137-160	prion protein	Mus musculus	164-168
32321762-7	2020	Using a sialic acid linkage-specific alkylamidation (SALSA) method to discriminate alpha2,3-linkage from alpha2,6-linkage, we found that N-acetylneuraminic acid in PrPC"s GPI side-chain is linked to galactose through an alpha2,3-linkage.	N-Acetylneuraminic Acid	137-160	glycoprotein hormone subunit alpha 2	Homo sapiens	105-111
32321762-8	2020	In summary, we report the GPI-glycan structure of human PrPC, including the omega-site amino acid for GPI attachment and the sialic acid linkage type.	N-Acetylneuraminic Acid	125-136	prion protein	Homo sapiens	56-60
32457377-0	2020	Discovery of a new sialic acid binding region that regulates Siglec-7.	N-Acetylneuraminic Acid	19-30	sialic acid binding Ig like lectin 7	Homo sapiens	61-69
32457377-2	2020	Siglec-7 is considered to function as an immunoreceptor in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	61-72	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
32457377-4	2020	Here, to gain new insights into the ligand-binding properties of Siglec-7, we carried out in silico analysis and site-directed mutagenesis, and found a new sialic acid-binding region (site 2 containing R67) in addition to the well-known primary ligand-binding region (site 1 containing R124).	N-Acetylneuraminic Acid	156-167	sialic acid binding Ig like lectin 7	Homo sapiens	65-73
31804700-5	2020	To this end, through a concerted effort of generation of random and site-directed mutagenesis libraries, subsequent screens, and positive and negative evolutionary selection protocols, we succeeded in identifying three enzyme variants of the neuraminidase from the soil bacterium Micromonospora viridifaciens with markedly altered specificity for the hydrolysis of natural Kdn (3-deoxy-d-glycero-d-galacto-non-2-ulosonic acid) glycosidic linkages compared to those of N-acetylneuraminic acid.	N-Acetylneuraminic Acid	468-491	neuraminidase 1	Homo sapiens	242-255
31697432-5	2020	Differential scanning fluorimetry demonstrates that YjhC binds N-acetylneuraminic acid and its lactone variant, along with NAD(H), which is consistent with its role as an oxidoreductase.	N-Acetylneuraminic Acid	63-86	oxidoreductase	Escherichia coli	171-185
32096498-4	2020	Peripheral blood neutrophils (PBNs) from tumor-bearing mice display high expression of l-selectin, which is well known to be targeted by the sialic acid (SA) ligand.	N-Acetylneuraminic Acid	141-152	selectin, lymphocyte	Mus musculus	87-97
32096498-4	2020	Peripheral blood neutrophils (PBNs) from tumor-bearing mice display high expression of l-selectin, which is well known to be targeted by the sialic acid (SA) ligand.	N-Acetylneuraminic Acid	154-156	selectin, lymphocyte	Mus musculus	87-97
32351730-1	2020	Purpose: Recent studies have indicated that N-acetylneuraminic acid (Neu5Ac) plays a key role in severe coronary artery diseases, involving RhoA signaling pathway activation, which is critically involved in cardiac fibrosis.	N-Acetylneuraminic Acid	44-67	ras homolog family member A	Homo sapiens	140-144
32351730-1	2020	Purpose: Recent studies have indicated that N-acetylneuraminic acid (Neu5Ac) plays a key role in severe coronary artery diseases, involving RhoA signaling pathway activation, which is critically involved in cardiac fibrosis.	N-Acetylneuraminic Acid	69-75	ras homolog family member A	Homo sapiens	140-144
32290341-5	2020	Among the list of differentially expressed genes, sialic acid-binding immunoglobulin (Ig)-like lectins (SIGLEC3, SIGLEC14, SIGLEC8), ribosomal proteins (RPL17, RPL34, RPS3A, MRPS33) and chemokines (CCL5, CCL24, CXCL13, CXCL9) were upregulated in Finnsheep, while four multidrug resistance-associated proteins (MRPs) were upregulated in Texel ewes.	N-Acetylneuraminic Acid	50-61	sialic acid-binding Ig-like lectin 14	Ovis aries	113-121
32290341-5	2020	Among the list of differentially expressed genes, sialic acid-binding immunoglobulin (Ig)-like lectins (SIGLEC3, SIGLEC14, SIGLEC8), ribosomal proteins (RPL17, RPL34, RPS3A, MRPS33) and chemokines (CCL5, CCL24, CXCL13, CXCL9) were upregulated in Finnsheep, while four multidrug resistance-associated proteins (MRPs) were upregulated in Texel ewes.	N-Acetylneuraminic Acid	50-61	sialic acid-binding Ig-like lectin 5	Ovis aries	123-130
32290341-5	2020	Among the list of differentially expressed genes, sialic acid-binding immunoglobulin (Ig)-like lectins (SIGLEC3, SIGLEC14, SIGLEC8), ribosomal proteins (RPL17, RPL34, RPS3A, MRPS33) and chemokines (CCL5, CCL24, CXCL13, CXCL9) were upregulated in Finnsheep, while four multidrug resistance-associated proteins (MRPs) were upregulated in Texel ewes.	N-Acetylneuraminic Acid	50-61	60S ribosomal protein L34	Ovis aries	160-165
32290341-5	2020	Among the list of differentially expressed genes, sialic acid-binding immunoglobulin (Ig)-like lectins (SIGLEC3, SIGLEC14, SIGLEC8), ribosomal proteins (RPL17, RPL34, RPS3A, MRPS33) and chemokines (CCL5, CCL24, CXCL13, CXCL9) were upregulated in Finnsheep, while four multidrug resistance-associated proteins (MRPs) were upregulated in Texel ewes.	N-Acetylneuraminic Acid	50-61	40S ribosomal protein S3a	Ovis aries	167-172
32290341-5	2020	Among the list of differentially expressed genes, sialic acid-binding immunoglobulin (Ig)-like lectins (SIGLEC3, SIGLEC14, SIGLEC8), ribosomal proteins (RPL17, RPL34, RPS3A, MRPS33) and chemokines (CCL5, CCL24, CXCL13, CXCL9) were upregulated in Finnsheep, while four multidrug resistance-associated proteins (MRPs) were upregulated in Texel ewes.	N-Acetylneuraminic Acid	50-61	28S ribosomal protein S33, mitochondrial	Ovis aries	174-180
32290341-5	2020	Among the list of differentially expressed genes, sialic acid-binding immunoglobulin (Ig)-like lectins (SIGLEC3, SIGLEC14, SIGLEC8), ribosomal proteins (RPL17, RPL34, RPS3A, MRPS33) and chemokines (CCL5, CCL24, CXCL13, CXCL9) were upregulated in Finnsheep, while four multidrug resistance-associated proteins (MRPs) were upregulated in Texel ewes.	N-Acetylneuraminic Acid	50-61	C-C motif chemokine 5	Ovis aries	198-202
32290341-5	2020	Among the list of differentially expressed genes, sialic acid-binding immunoglobulin (Ig)-like lectins (SIGLEC3, SIGLEC14, SIGLEC8), ribosomal proteins (RPL17, RPL34, RPS3A, MRPS33) and chemokines (CCL5, CCL24, CXCL13, CXCL9) were upregulated in Finnsheep, while four multidrug resistance-associated proteins (MRPs) were upregulated in Texel ewes.	N-Acetylneuraminic Acid	50-61	C-C motif chemokine 24	Ovis aries	204-209
32290341-5	2020	Among the list of differentially expressed genes, sialic acid-binding immunoglobulin (Ig)-like lectins (SIGLEC3, SIGLEC14, SIGLEC8), ribosomal proteins (RPL17, RPL34, RPS3A, MRPS33) and chemokines (CCL5, CCL24, CXCL13, CXCL9) were upregulated in Finnsheep, while four multidrug resistance-associated proteins (MRPs) were upregulated in Texel ewes.	N-Acetylneuraminic Acid	50-61	C-X-C motif chemokine 13	Ovis aries	211-217
32290341-5	2020	Among the list of differentially expressed genes, sialic acid-binding immunoglobulin (Ig)-like lectins (SIGLEC3, SIGLEC14, SIGLEC8), ribosomal proteins (RPL17, RPL34, RPS3A, MRPS33) and chemokines (CCL5, CCL24, CXCL13, CXCL9) were upregulated in Finnsheep, while four multidrug resistance-associated proteins (MRPs) were upregulated in Texel ewes.	N-Acetylneuraminic Acid	50-61	C-X-C motif chemokine 9	Ovis aries	219-224
20301643-3	1993	DIAGNOSIS/TESTING: Free sialic acid storage disorders result from defective free sialic acid transport out of lysosomes as a consequence of mutations in SLC17A5, encoding the lysosomal transport protein sialin.	N-Acetylneuraminic Acid	24-35	solute carrier family 17 member 5	Homo sapiens	153-160
32087947-2	2020	We investigated the impact of reduced sialylation in the brain of mice heterozygous for the enzyme glucosamine-2-epimerase/N-acetylmannosamine kinase (GNE+/-) that is essential for sialic acid biosynthesis.	N-Acetylneuraminic Acid	181-192	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	151-154
31669471-7	2020	In contrast, receptors possess higher level of alpha2,3 sialic acid residues and lower level of tri-/tetra-antennary complex type N-glycans and terminal mannose in high-mannose structures.	N-Acetylneuraminic Acid	56-67	immunoglobulin kappa variable 2-24	Homo sapiens	47-55
32322597-2	2020	Previous studies have shown that Siglec7 and Siglec9 are expressed on NK cells, which negatively regulate the function of NK cells and modulate the immune response through the interaction of sialic acid-containing ligands.	N-Acetylneuraminic Acid	191-202	sialic acid binding Ig like lectin 7	Homo sapiens	33-40
32322597-2	2020	Previous studies have shown that Siglec7 and Siglec9 are expressed on NK cells, which negatively regulate the function of NK cells and modulate the immune response through the interaction of sialic acid-containing ligands.	N-Acetylneuraminic Acid	191-202	sialic acid binding Ig like lectin 9	Homo sapiens	45-52
31273092-2	2020	Glycoprotein Ibalpha contains many glycans, capped by sialic acid.	N-Acetylneuraminic Acid	54-65	glycoprotein Ib platelet subunit alpha	Homo sapiens	0-20
32269562-4	2020	Here, we report that factor H, a sialic acid binder, interacts with influenza A virus (IAV) and modulates IAV entry, as evident from down-regulation of matrix protein 1 (M1) in H1N1 subtype-infected cells and up-regulation of M1 expression in H3N2-infected A549 cells.	N-Acetylneuraminic Acid	33-44	complement factor H	Homo sapiens	21-29
32269562-4	2020	Here, we report that factor H, a sialic acid binder, interacts with influenza A virus (IAV) and modulates IAV entry, as evident from down-regulation of matrix protein 1 (M1) in H1N1 subtype-infected cells and up-regulation of M1 expression in H3N2-infected A549 cells.	N-Acetylneuraminic Acid	33-44	cholinergic receptor muscarinic 1	Homo sapiens	170-172
32111064-0	2020	Molecular Interactions of the Polysialytransferase Domain (PSTD) in ST8Sia IV with CMP-Sialic Acid and Polysialic Acid Required for Polysialylation of the Neural Cell Adhesion Molecule Proteins: An NMR Study.	N-Acetylneuraminic Acid	87-98	Oncogene OVC (ovarian adenocarcinoma oncogene)	Homo sapiens	68-71
32111064-0	2020	Molecular Interactions of the Polysialytransferase Domain (PSTD) in ST8Sia IV with CMP-Sialic Acid and Polysialic Acid Required for Polysialylation of the Neural Cell Adhesion Molecule Proteins: An NMR Study.	N-Acetylneuraminic Acid	87-98	neural cell adhesion molecule 1	Homo sapiens	155-184
32111064-3	2020	Two members of the ST8Sia family of alpha2,8-polysialyltransferases (polySTs), ST8Sia II (STX) and ST8Sia IV (PST) both catalyze synthesis of polySia when activated cytidine monophosphate(CMP)-Sialic acid (CMP-Sia) is translocate into the lumen of the Golgi apparatus.	N-Acetylneuraminic Acid	193-204	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	79-88
32111064-3	2020	Two members of the ST8Sia family of alpha2,8-polysialyltransferases (polySTs), ST8Sia II (STX) and ST8Sia IV (PST) both catalyze synthesis of polySia when activated cytidine monophosphate(CMP)-Sialic acid (CMP-Sia) is translocate into the lumen of the Golgi apparatus.	N-Acetylneuraminic Acid	193-204	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	90-93
32111064-3	2020	Two members of the ST8Sia family of alpha2,8-polysialyltransferases (polySTs), ST8Sia II (STX) and ST8Sia IV (PST) both catalyze synthesis of polySia when activated cytidine monophosphate(CMP)-Sialic acid (CMP-Sia) is translocate into the lumen of the Golgi apparatus.	N-Acetylneuraminic Acid	193-204	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	99-108
32111064-3	2020	Two members of the ST8Sia family of alpha2,8-polysialyltransferases (polySTs), ST8Sia II (STX) and ST8Sia IV (PST) both catalyze synthesis of polySia when activated cytidine monophosphate(CMP)-Sialic acid (CMP-Sia) is translocate into the lumen of the Golgi apparatus.	N-Acetylneuraminic Acid	193-204	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	110-113
31930911-13	2020	Finally, our finding that hItln-1 avoids binding prevalent glycans with a terminal 1,2-diol (e.g., N-acetyl-neuraminic acid and l-glycero-alpha-d-manno-heptose) suggests the lectin has evolved to recognize distinct bacterial species.	N-Acetylneuraminic Acid	99-123	intelectin 1	Homo sapiens	26-33
31776280-1	2020	The influenza A virus (IAV) envelope protein hemagglutinin binds alpha2,6- or alpha2,3-linked sialic acid as a host cell receptor.	N-Acetylneuraminic Acid	94-105	glycoprotein hormone subunit alpha 2	Homo sapiens	65-71
31776280-1	2020	The influenza A virus (IAV) envelope protein hemagglutinin binds alpha2,6- or alpha2,3-linked sialic acid as a host cell receptor.	N-Acetylneuraminic Acid	94-105	glycoprotein hormone subunit alpha 2	Homo sapiens	78-84
20301643-3	1993	DIAGNOSIS/TESTING: Free sialic acid storage disorders result from defective free sialic acid transport out of lysosomes as a consequence of mutations in SLC17A5, encoding the lysosomal transport protein sialin.	N-Acetylneuraminic Acid	24-35	solute carrier family 17 member 5	Homo sapiens	203-209
20301643-3	1993	DIAGNOSIS/TESTING: Free sialic acid storage disorders result from defective free sialic acid transport out of lysosomes as a consequence of mutations in SLC17A5, encoding the lysosomal transport protein sialin.	N-Acetylneuraminic Acid	81-92	solute carrier family 17 member 5	Homo sapiens	153-160
20301643-3	1993	DIAGNOSIS/TESTING: Free sialic acid storage disorders result from defective free sialic acid transport out of lysosomes as a consequence of mutations in SLC17A5, encoding the lysosomal transport protein sialin.	N-Acetylneuraminic Acid	81-92	solute carrier family 17 member 5	Homo sapiens	203-209
31805552-3	2020	Here we show that in response to known inflammasome activators (ATP, nigericin) or the sialic acid-expressing human bacterial pathogen group B Streptococcus (GBS), the presence of Siglec-14 enhances, whereas Siglec-5 reduces, inflammasome activation and macrophage IL-1beta release.	N-Acetylneuraminic Acid	87-98	sialic acid binding Ig like lectin 14	Homo sapiens	180-189
31095840-3	2020	We provide new molecular insights into the binding mode of sialoglycans in complex with h-CD22, highlighting the role of the sialic acid galactose moieties in the recognition process, elucidating the conformational behaviour of complex-type N-glycans bound to Siglec-2 and dissecting the formation of CD22 homo-oligomers on the B-cell surface.	N-Acetylneuraminic Acid	125-136	CD22 molecule	Homo sapiens	90-94
31250000-4	2020	METHODS: We examined the effect of ZIKV NS1 on expression and release of heparan sulfate (HS), hyaluronic acid (HA), and sialic acid on human trophoblast cell lines and anchoring villous explants from first-trimester placentas infected with ZIKV ex vivo.	N-Acetylneuraminic Acid	121-132	influenza virus NS1A binding protein	Homo sapiens	40-43
31805552-3	2020	Here we show that in response to known inflammasome activators (ATP, nigericin) or the sialic acid-expressing human bacterial pathogen group B Streptococcus (GBS), the presence of Siglec-14 enhances, whereas Siglec-5 reduces, inflammasome activation and macrophage IL-1beta release.	N-Acetylneuraminic Acid	87-98	sialic acid binding Ig like lectin 5	Homo sapiens	208-216
31805552-3	2020	Here we show that in response to known inflammasome activators (ATP, nigericin) or the sialic acid-expressing human bacterial pathogen group B Streptococcus (GBS), the presence of Siglec-14 enhances, whereas Siglec-5 reduces, inflammasome activation and macrophage IL-1beta release.	N-Acetylneuraminic Acid	87-98	interleukin 1 alpha	Homo sapiens	265-273
31805552-5	2020	Another leading pathogen, Streptococcus pneumoniae, lacks sialic acid but rather prominently expresses a sialidase, which cleaves sialic acid from macrophages, eliminating cis- interactions with the lectin receptor, thus attenuating Siglec-14 induced IL-1beta secretion.	N-Acetylneuraminic Acid	130-141	sialic acid binding Ig like lectin 14	Homo sapiens	233-242
31805552-5	2020	Another leading pathogen, Streptococcus pneumoniae, lacks sialic acid but rather prominently expresses a sialidase, which cleaves sialic acid from macrophages, eliminating cis- interactions with the lectin receptor, thus attenuating Siglec-14 induced IL-1beta secretion.	N-Acetylneuraminic Acid	130-141	interleukin 1 alpha	Homo sapiens	251-259
32515567-8	2020	RESULTS AND DISCUSSION: The method is based on the ability of neuraminidase to hydrolyze sialic acid residues on the cell surface of erythrocytes, that deprives red blood cells to be agglutinated with the flu virus, since these sialic glycans provide virus attachment and hemagglutination.	N-Acetylneuraminic Acid	89-100	neuraminidase 1	Homo sapiens	62-75
31216452-3	2020	Previous efforts for increasing EPO"s efficacy have focused on glycosylation modification via adding more sialic acid antenna and generates more negative charged protein.	N-Acetylneuraminic Acid	106-117	erythropoietin	Homo sapiens	32-35
31515676-7	2019	As a consequence of blocking Neu1, honokiol reduced the levels of sialic acid in the two subtypes of breast cancer.	N-Acetylneuraminic Acid	66-77	neuraminidase 1	Homo sapiens	29-33
31861593-0	2019	Molecular Conformations of Di-, Tri-, and Tetra-alpha-(2 8)-Linked Sialic Acid from NMR Spectroscopy and MD Simulations.	N-Acetylneuraminic Acid	67-78	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	32-35
31476363-2	2019	Sialic acid (Sia), and in particular, 5-N-acetylneuraminic acid (Neu5Ac), is chemically bound to galactose and the underlying glycan via alpha2-3 or alpha2-6 glycosidic linkage (i.e., Siaalpha2-3Galactose or Siaalpha2-6Galactose), conferring two different cell surface structures that affects cell to cell communication and interactions with foreign agents including microparasites and toxins.	N-Acetylneuraminic Acid	0-11	immunoglobulin binding protein 1	Homo sapiens	149-157
31476363-2	2019	Sialic acid (Sia), and in particular, 5-N-acetylneuraminic acid (Neu5Ac), is chemically bound to galactose and the underlying glycan via alpha2-3 or alpha2-6 glycosidic linkage (i.e., Siaalpha2-3Galactose or Siaalpha2-6Galactose), conferring two different cell surface structures that affects cell to cell communication and interactions with foreign agents including microparasites and toxins.	N-Acetylneuraminic Acid	0-3	immunoglobulin binding protein 1	Homo sapiens	149-157
31476363-2	2019	Sialic acid (Sia), and in particular, 5-N-acetylneuraminic acid (Neu5Ac), is chemically bound to galactose and the underlying glycan via alpha2-3 or alpha2-6 glycosidic linkage (i.e., Siaalpha2-3Galactose or Siaalpha2-6Galactose), conferring two different cell surface structures that affects cell to cell communication and interactions with foreign agents including microparasites and toxins.	N-Acetylneuraminic Acid	38-63	immunoglobulin binding protein 1	Homo sapiens	149-157
31476363-2	2019	Sialic acid (Sia), and in particular, 5-N-acetylneuraminic acid (Neu5Ac), is chemically bound to galactose and the underlying glycan via alpha2-3 or alpha2-6 glycosidic linkage (i.e., Siaalpha2-3Galactose or Siaalpha2-6Galactose), conferring two different cell surface structures that affects cell to cell communication and interactions with foreign agents including microparasites and toxins.	N-Acetylneuraminic Acid	65-71	immunoglobulin binding protein 1	Homo sapiens	149-157
31781090-11	2019	Comparable results were achieved, when sialic acids were targeted by neuraminidase digestion, indicating a sialic acid dependent inhibition of NET release.	N-Acetylneuraminic Acid	39-50	neuraminidase 1	Bos taurus	69-82
31728195-1	2019	Background: N-glycolylneuraminic acid (Neu5Gc) is synthesized from its precursor N-acetylneuraminic acid (Neu5Ac) by cytidine-5"-monophospho-N acetylneuraminic acid hydroxylase (CMAH), which is encoded by the CMAH gene.	N-Acetylneuraminic Acid	81-104	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Felis catus	178-182
31728195-1	2019	Background: N-glycolylneuraminic acid (Neu5Gc) is synthesized from its precursor N-acetylneuraminic acid (Neu5Ac) by cytidine-5"-monophospho-N acetylneuraminic acid hydroxylase (CMAH), which is encoded by the CMAH gene.	N-Acetylneuraminic Acid	81-104	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Felis catus	209-213
31728195-1	2019	Background: N-glycolylneuraminic acid (Neu5Gc) is synthesized from its precursor N-acetylneuraminic acid (Neu5Ac) by cytidine-5"-monophospho-N acetylneuraminic acid hydroxylase (CMAH), which is encoded by the CMAH gene.	N-Acetylneuraminic Acid	106-112	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Felis catus	178-182
31728195-1	2019	Background: N-glycolylneuraminic acid (Neu5Gc) is synthesized from its precursor N-acetylneuraminic acid (Neu5Ac) by cytidine-5"-monophospho-N acetylneuraminic acid hydroxylase (CMAH), which is encoded by the CMAH gene.	N-Acetylneuraminic Acid	106-112	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Felis catus	209-213
31517596-5	2019	Indeed SiaPG required NanS to maximize sialic acid harvesting from heavily O-acetylated substrates such as bovine salivary mucin, hinting at the possibility of interspecies cooperation in sialic acid release from host sources by these members of the oral microbiota.	N-Acetylneuraminic Acid	39-50	N-acetylneuraminate synthase	Bos taurus	22-26
31577134-0	2019	Comparative Glycomic Analysis of Sialyl Linkage Isomers by Sialic Acid Linkage-Specific Alkylamidation in Combination with Stable Isotope Labeling of alpha2,3-Linked Sialic Acid Residues.	N-Acetylneuraminic Acid	166-177	immunoglobulin kappa variable 2-24	Homo sapiens	150-158
31577134-3	2019	Herein, we have investigated an isotope labeling of alpha2,3-linked sialic acid residues (iSALSA) using amine hydrochloride salts.	N-Acetylneuraminic Acid	68-79	immunoglobulin kappa variable 2-24	Homo sapiens	52-60
31317538-5	2019	This result could be reasonably explained by our hypothesis that the turnover rate of Neu5Ac to Neu5Gc catalyzed by CMP-Neu5Ac hydroxylase would be reduced through facilitated transportation of Neu5Ac into Golgi apparatus by coexpression of CMP-SAT.	N-Acetylneuraminic Acid	86-92	cytidine monophosphate-N-acetylneuraminic acid hydroxylase	Cricetulus griseus	116-138
31526452-2	2019	Previously, we determined that DENV nonstructural protein 1 (NS1) induces endothelial hyperpermeability, disrupts the endothelial glycocalyx layer (EGL) in vitro and triggers shedding of structural components, including sialic acid (Sia) and heparan sulfate.	N-Acetylneuraminic Acid	220-231	influenza virus NS1A binding protein	Homo sapiens	61-64
30686127-1	2019	Abbreviations HA Hemagglutinin MD Molecular Dynamics MM-PBSA Molecular Mechanics Poisson-Boltzmann Surface Area NA Neuraminidase NAMD Nanoscale Molecular Dynamic Simulation PMEMD Particle Mesh Ewald Molecular Dynamics RMSD Root-Mean-Square Deviation RMSF Root-Mean-Square Fluctuation SIA sialic acid VMD Visual Molecular Dynamics Communicated by Ramaswamy H. Sarma.	N-Acetylneuraminic Acid	288-299	neuraminidase 1	Homo sapiens	115-128
31517596-5	2019	Indeed SiaPG required NanS to maximize sialic acid harvesting from heavily O-acetylated substrates such as bovine salivary mucin, hinting at the possibility of interspecies cooperation in sialic acid release from host sources by these members of the oral microbiota.	N-Acetylneuraminic Acid	39-50	mucin 1, cell surface associated	Bos taurus	123-128
31517596-6	2019	Activity of SiaPG and P. gingivalis was inhibited using the commercially available chemotherapeutic zanamivir, indicating its potential as a virulence inhibitor, which also inhibited sialic acid release from mucin, and was capable of inhibiting biofilm formation of P. gingivalis on oral glycoprotein sources.	N-Acetylneuraminic Acid	183-194	mucin 1, cell surface associated	Bos taurus	208-213
31180129-9	2019	Chicken mucin monosaccharides included l-fucose (Fuc), d-mannose (Man), d-galactose (Gal), N-acetyl-d-galactosamine (GalNAc), N-acetyl-d-glucosamine (GlcNAc), and Neu5Ac (sialic acid).	N-Acetylneuraminic Acid	163-169	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	8-13
31549502-1	2019	NeuB is a bacterial sialic acid synthase used by neuroinvasive bacteria to synthesize N-acetylneuraminate (NeuNAc), helping them to evade the host immune system.	N-Acetylneuraminic Acid	86-105	N-acetylneuraminate synthase	Homo sapiens	20-40
31681287-2	2019	Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group addition catalyzed by CMP-Neu5Ac hydroxylase enzyme (CMAH).	N-Acetylneuraminic Acid	33-56	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	130-159
31681287-2	2019	Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group addition catalyzed by CMP-Neu5Ac hydroxylase enzyme (CMAH).	N-Acetylneuraminic Acid	33-56	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	161-165
31681287-2	2019	Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group addition catalyzed by CMP-Neu5Ac hydroxylase enzyme (CMAH).	N-Acetylneuraminic Acid	58-64	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	130-159
31681287-2	2019	Neu5Gc synthesis starts from the N-acetylneuraminic acid (Neu5Ac) precursor modified by an hydroxylic group addition catalyzed by CMP-Neu5Ac hydroxylase enzyme (CMAH).	N-Acetylneuraminic Acid	58-64	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	161-165
31465299-3	2019	One promising new approach is to deplete eosinophils and inhibit MCs with a monoclonal antibody (mAb) against sialic acid-binding immunoglobulin-like lectin 8 (Siglec-8), an inhibitory receptor selectively expressed on MCs and eosinophils.	N-Acetylneuraminic Acid	110-121	sialic acid binding Ig like lectin 8	Homo sapiens	160-168
31121216-6	2019	NANP is the third enzyme in sialic acid biosynthesis and dephosphorylates sialic acid 9-phosphate to free sialic acid.	N-Acetylneuraminic Acid	28-39	N-acetylneuraminic acid phosphatase	Homo sapiens	0-4
31121216-6	2019	NANP is the third enzyme in sialic acid biosynthesis and dephosphorylates sialic acid 9-phosphate to free sialic acid.	N-Acetylneuraminic Acid	74-85	N-acetylneuraminic acid phosphatase	Homo sapiens	0-4
31121216-7	2019	LC-MS analysis of sialic acid metabolites showed that CMP-sialic acid was dramatically reduced in GNE and NANS KO cells and undetectable in CMAS KO.	N-Acetylneuraminic Acid	18-29	N-acetylneuraminate synthase	Homo sapiens	106-110
31288173-5	2019	Here, an E-selectin-targeting sialic acid - polyethylene glycol - poly (lactic-co-glycolic acid) (SAPP) copolymer was designed for delivering hydrophobic minocycline to achieve combinational therapy of SCI.	N-Acetylneuraminic Acid	30-41	selectin E	Rattus norvegicus	9-19
31288173-8	2019	The SAPP micelles were efficiently accumulated in the lesion site of SCI rats via the specific binding between sialic acid and E-selectin.	N-Acetylneuraminic Acid	111-122	selectin E	Rattus norvegicus	127-137
31628314-3	2019	We report that beta2AR activation requires two asparagine-branched glycan chains with terminally exposed N-acetyl-neuraminic acid (sialic acid, Neu5Ac) residues located at a specific distance in its N-terminus, while being independent of surrounding amino-acid residues.	N-Acetylneuraminic Acid	105-129	adenosine A2a receptor	Homo sapiens	15-22
31628314-3	2019	We report that beta2AR activation requires two asparagine-branched glycan chains with terminally exposed N-acetyl-neuraminic acid (sialic acid, Neu5Ac) residues located at a specific distance in its N-terminus, while being independent of surrounding amino-acid residues.	N-Acetylneuraminic Acid	131-142	adenosine A2a receptor	Homo sapiens	15-22
31628314-3	2019	We report that beta2AR activation requires two asparagine-branched glycan chains with terminally exposed N-acetyl-neuraminic acid (sialic acid, Neu5Ac) residues located at a specific distance in its N-terminus, while being independent of surrounding amino-acid residues.	N-Acetylneuraminic Acid	144-150	adenosine A2a receptor	Homo sapiens	15-22
31628314-6	2019	This previously unknown glycan-dependent mode of allosteric mechanical activation of a G protein-coupled receptor contributes to meningococcal species selectivity, since Neu5Ac is only abundant in humans due to the loss of CMAH, the enzyme converting Neu5Ac into N-glycolyl-neuraminic acid in other mammals.	N-Acetylneuraminic Acid	251-257	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	223-227
31121216-7	2019	LC-MS analysis of sialic acid metabolites showed that CMP-sialic acid was dramatically reduced in GNE and NANS KO cells and undetectable in CMAS KO.	N-Acetylneuraminic Acid	58-69	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	98-101
31121216-7	2019	LC-MS analysis of sialic acid metabolites showed that CMP-sialic acid was dramatically reduced in GNE and NANS KO cells and undetectable in CMAS KO.	N-Acetylneuraminic Acid	58-69	N-acetylneuraminate synthase	Homo sapiens	106-110
31121216-8	2019	In agreement with normal cell surface sialylation, CMP-sialic acid levels in NANP KO were comparable to WT cells, even though sialic acid 9-phosphate, the substrate of NANP accumulated.	N-Acetylneuraminic Acid	55-66	N-acetylneuraminic acid phosphatase	Homo sapiens	77-81
31180129-9	2019	Chicken mucin monosaccharides included l-fucose (Fuc), d-mannose (Man), d-galactose (Gal), N-acetyl-d-galactosamine (GalNAc), N-acetyl-d-glucosamine (GlcNAc), and Neu5Ac (sialic acid).	N-Acetylneuraminic Acid	171-182	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	8-13
31180129-12	2019	Finally, anaerobic incubation of chicken mucin O-glycans with C. perfringens and subsequent analysis of the glycans revealed that there was preferential removal of Neu5Ac.	N-Acetylneuraminic Acid	164-170	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	41-46
31387789-2	2019	Kinetic inhibition assays and Western blotting revealed the Neu5Ac2en-based 7 to be an effective probe for the labeling of a purified gut microbial sialidase (BDI_2946) and a purified human sialic acid binding protein (hCD33).	N-Acetylneuraminic Acid	190-201	CD33 molecule	Homo sapiens	219-224
31369984-1	2019	Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of the CD33 sialic acid-binding domain confers protection.	N-Acetylneuraminic Acid	139-150	CD33 molecule	Homo sapiens	40-44
31369984-1	2019	Polymorphism in the microglial receptor CD33 gene has been linked to late-onset Alzheimer disease (AD), and reduced expression of the CD33 sialic acid-binding domain confers protection.	N-Acetylneuraminic Acid	139-150	CD33 molecule	Homo sapiens	134-138
31369984-4	2019	We report here the crystal structures of CD33 alone and bound to a subtype-selective sialic acid mimetic called P22 and use them to identify key binding residues by site-directed mutagenesis and binding assays to reveal the molecular basis for its selectivity toward sialylated glycoproteins and glycolipids.	N-Acetylneuraminic Acid	85-96	CD33 molecule	Homo sapiens	41-45
31369984-6	2019	Thus, the sialic acid-binding site on CD33 is a promising pharmacophore for developing therapeutics that promote clearance of the Abeta peptide that is thought to cause AD.	N-Acetylneuraminic Acid	10-21	CD33 molecule	Homo sapiens	38-42
31339142-3	2019	Glycan microarray binding studies indicate that Siglec-7 does not recognize DSGb5, and preferentially binds Neu5Acalpha(2,8)Neu5Ac containing glycans.	N-Acetylneuraminic Acid	108-114	sialic acid binding Ig like lectin 7	Homo sapiens	48-56
30535529-9	2019	Furthermore, the application of alpha2-3 neuraminidase enabled the partial assignment of peaks in the arrival time distribution considering their sialic acid linkages (alpha2-3/alpha2-6).	N-Acetylneuraminic Acid	146-157	immunoglobulin binding protein 1	Homo sapiens	177-185
31004871-3	2019	Sialic acid, which is a component of the glycocalyx, plays a key role in antioxidant activity and is catalyzed by the sialyltransferase, ST6Gal-I.	N-Acetylneuraminic Acid	0-11	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Rattus norvegicus	137-145
31308178-2	2019	By altering the N-glycosylation machinery in the endoplasmic reticulum and Golgi, proinflammatory cytokines promote the modification of endothelial glycoproteins such as vascular endothelial growth factor receptor 2 (VEGFR2) with sialic acid-capped N-glycans.	N-Acetylneuraminic Acid	230-241	kinase insert domain receptor	Homo sapiens	170-215
31308178-6	2019	Furthermore, we report that VEGFR2 Asn-247-linked glycans capped with sialic acid oppose ligand-mediated VEGFR2 activation, whereas the uncapped asialo-glycans favor activation of this receptor.	N-Acetylneuraminic Acid	70-81	kinase insert domain receptor	Homo sapiens	28-34
31308178-6	2019	Furthermore, we report that VEGFR2 Asn-247-linked glycans capped with sialic acid oppose ligand-mediated VEGFR2 activation, whereas the uncapped asialo-glycans favor activation of this receptor.	N-Acetylneuraminic Acid	70-81	kinase insert domain receptor	Homo sapiens	105-111
31308178-7	2019	We propose that N-glycosylation, specifically the capping of N-glycans at Asn-247 by sialic acid, tunes ligand-dependent activation and signaling of VEGFR2 in endothelial cells.	N-Acetylneuraminic Acid	85-96	kinase insert domain receptor	Homo sapiens	149-155
31507595-3	2019	In suppressing activated T cells, it first sequesters the pro-inflammatory high mobility group Box 1 (HMGB1) protein, which facilitates its binding to the inhibitory sialic acid-binding immunoglobulin-like lectin-10 (Siglec-10) receptor.	N-Acetylneuraminic Acid	166-177	high mobility group box 1	Homo sapiens	75-100
31507595-3	2019	In suppressing activated T cells, it first sequesters the pro-inflammatory high mobility group Box 1 (HMGB1) protein, which facilitates its binding to the inhibitory sialic acid-binding immunoglobulin-like lectin-10 (Siglec-10) receptor.	N-Acetylneuraminic Acid	166-177	high mobility group box 1	Homo sapiens	102-107
30844664-4	2019	The ELISA assay was performed to evaluate sialic acid (SA) influence on integrin alpha5beta1 binding to fibronectin (FN).	N-Acetylneuraminic Acid	42-53	fibronectin 1	Homo sapiens	104-115
30844664-4	2019	The ELISA assay was performed to evaluate sialic acid (SA) influence on integrin alpha5beta1 binding to fibronectin (FN).	N-Acetylneuraminic Acid	42-53	fibronectin 1	Homo sapiens	117-119
30844664-9	2019	Although metastatic cells underwent more pronounced desialylation than primary cells, invasion of primary WM115 cells was more dependent on the presence of alpha2-3 linked SA than it was in the case of metastatic WM266-4 cells.	N-Acetylneuraminic Acid	172-174	immunoglobulin kappa variable 2-24	Homo sapiens	156-164
31411573-1	2019	CD33 is a myeloid-associated marker and belongs to the sialic acid-binding immunoglobulin (Ig)-like lectin (Siglec) family.	N-Acetylneuraminic Acid	55-66	CD33 molecule	Homo sapiens	0-4
31332008-6	2019	Humans exhibit a species-specific deficiency of the sialic acid N-glycolylneuraminic acid (Neu5Gc), due to pseudogenization of cytidine monophosphate-N-acetylneuraminic acid (Neu5Ac) hydroxylase (CMAH), which occurred in hominin ancestors ~2 to 3 Mya.	N-Acetylneuraminic Acid	52-63	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	196-200
31138648-1	2019	To analyze the binding specificity of a sialic acid-recognizing lectin, sialic acid-binding Ig-like lectin 7 (SIGLEC7), to disialyl gangliosides (GD3s), here we established GD3-expressing cells by introducing GD3 synthase (GD3S or ST8SIA1) cDNA into a colon cancer cell line, DLD-1, that expresses no ligands for the recombinant protein SIGLEC7-Fc.	N-Acetylneuraminic Acid	40-51	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	146-150
30890358-1	2019	Asialo-human transferrin (asialo-hTf) is a glycoform of the human serum protein transferrin characterized by the lack of the sialic acid (SA) terminal unit.	N-Acetylneuraminic Acid	125-136	transferrin	Homo sapiens	13-24
30890358-1	2019	Asialo-human transferrin (asialo-hTf) is a glycoform of the human serum protein transferrin characterized by the lack of the sialic acid (SA) terminal unit.	N-Acetylneuraminic Acid	125-136	coagulation factor III, tissue factor	Homo sapiens	33-36
30890358-1	2019	Asialo-human transferrin (asialo-hTf) is a glycoform of the human serum protein transferrin characterized by the lack of the sialic acid (SA) terminal unit.	N-Acetylneuraminic Acid	125-136	transferrin	Homo sapiens	80-91
30890358-1	2019	Asialo-human transferrin (asialo-hTf) is a glycoform of the human serum protein transferrin characterized by the lack of the sialic acid (SA) terminal unit.	N-Acetylneuraminic Acid	138-140	transferrin	Homo sapiens	13-24
30890358-1	2019	Asialo-human transferrin (asialo-hTf) is a glycoform of the human serum protein transferrin characterized by the lack of the sialic acid (SA) terminal unit.	N-Acetylneuraminic Acid	138-140	coagulation factor III, tissue factor	Homo sapiens	33-36
30890358-1	2019	Asialo-human transferrin (asialo-hTf) is a glycoform of the human serum protein transferrin characterized by the lack of the sialic acid (SA) terminal unit.	N-Acetylneuraminic Acid	138-140	transferrin	Homo sapiens	80-91
31490109-6	2019	Conclusion: We found the impact to be specific to the sialylation linkage type, in other words, alpha2,3- versus alpha2,6-linked sialic acid attached to the terminal galactose residues.	N-Acetylneuraminic Acid	129-140	immunoglobulin kappa variable 2-24	Homo sapiens	96-104
31490109-6	2019	Conclusion: We found the impact to be specific to the sialylation linkage type, in other words, alpha2,3- versus alpha2,6-linked sialic acid attached to the terminal galactose residues.	N-Acetylneuraminic Acid	129-140	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	113-121
31138648-0	2019	The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface.	N-Acetylneuraminic Acid	88-99	GRDX	Homo sapiens	43-46
31138648-0	2019	The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface.	N-Acetylneuraminic Acid	88-99	GRDX	Homo sapiens	65-68
31138648-0	2019	The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface.	N-Acetylneuraminic Acid	88-99	sialic acid binding Ig like lectin 7	Homo sapiens	115-122
31138648-1	2019	To analyze the binding specificity of a sialic acid-recognizing lectin, sialic acid-binding Ig-like lectin 7 (SIGLEC7), to disialyl gangliosides (GD3s), here we established GD3-expressing cells by introducing GD3 synthase (GD3S or ST8SIA1) cDNA into a colon cancer cell line, DLD-1, that expresses no ligands for the recombinant protein SIGLEC7-Fc.	N-Acetylneuraminic Acid	40-51	sialic acid binding Ig like lectin 7	Homo sapiens	72-108
31138648-1	2019	To analyze the binding specificity of a sialic acid-recognizing lectin, sialic acid-binding Ig-like lectin 7 (SIGLEC7), to disialyl gangliosides (GD3s), here we established GD3-expressing cells by introducing GD3 synthase (GD3S or ST8SIA1) cDNA into a colon cancer cell line, DLD-1, that expresses no ligands for the recombinant protein SIGLEC7-Fc.	N-Acetylneuraminic Acid	40-51	sialic acid binding Ig like lectin 7	Homo sapiens	110-117
31063704-8	2019	Domains mimicking sKlotho"s sialic acid-recognizing activity inhibit TRPC6.	N-Acetylneuraminic Acid	28-39	transient receptor potential cation channel subfamily C member 6	Homo sapiens	69-74
31138648-1	2019	To analyze the binding specificity of a sialic acid-recognizing lectin, sialic acid-binding Ig-like lectin 7 (SIGLEC7), to disialyl gangliosides (GD3s), here we established GD3-expressing cells by introducing GD3 synthase (GD3S or ST8SIA1) cDNA into a colon cancer cell line, DLD-1, that expresses no ligands for the recombinant protein SIGLEC7-Fc.	N-Acetylneuraminic Acid	40-51	GRDX	Homo sapiens	146-149
31138648-1	2019	To analyze the binding specificity of a sialic acid-recognizing lectin, sialic acid-binding Ig-like lectin 7 (SIGLEC7), to disialyl gangliosides (GD3s), here we established GD3-expressing cells by introducing GD3 synthase (GD3S or ST8SIA1) cDNA into a colon cancer cell line, DLD-1, that expresses no ligands for the recombinant protein SIGLEC7-Fc.	N-Acetylneuraminic Acid	40-51	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	223-227
31138648-1	2019	To analyze the binding specificity of a sialic acid-recognizing lectin, sialic acid-binding Ig-like lectin 7 (SIGLEC7), to disialyl gangliosides (GD3s), here we established GD3-expressing cells by introducing GD3 synthase (GD3S or ST8SIA1) cDNA into a colon cancer cell line, DLD-1, that expresses no ligands for the recombinant protein SIGLEC7-Fc.	N-Acetylneuraminic Acid	40-51	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	231-238
31138648-1	2019	To analyze the binding specificity of a sialic acid-recognizing lectin, sialic acid-binding Ig-like lectin 7 (SIGLEC7), to disialyl gangliosides (GD3s), here we established GD3-expressing cells by introducing GD3 synthase (GD3S or ST8SIA1) cDNA into a colon cancer cell line, DLD-1, that expresses no ligands for the recombinant protein SIGLEC7-Fc.	N-Acetylneuraminic Acid	40-51	sialic acid binding Ig like lectin 7	Homo sapiens	337-344
31289278-4	2019	The use of cell lines for testing GM3(Neu5Gc)-targeting strategies, in particular for human malignancies, is complicated by the absence in humans of functional cytidine monophospho-N-acetyl-neuraminic acid hydroxylase (CMAH), the enzyme required for Neu5Gc sialic acid biosynthesis.	N-Acetylneuraminic Acid	257-268	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	160-217
31108259-10	2019	Herein, we designed and synthesized a sialic acid (SA)-stearic acid conjugate modified on the surface of nanocomplexes to encapsulate IBR (SA/IBR/EPG) for targeted delivery of IBR to TAMs.	N-Acetylneuraminic Acid	38-49	epithelial mitogen	Homo sapiens	139-149
31247730-0	2019	Glycopeptide Nanofiber Platform for Abeta-Sialic Acid Interaction Analysis and Highly Sensitive Detection of Abeta.	N-Acetylneuraminic Acid	42-53	amyloid beta precursor protein	Homo sapiens	36-41
31108259-3	2019	Herein, we designed and synthesized a sialic acid (SA)-stearic acid conjugate modified on the surface of nanocomplexes to encapsulate IBR (SA/IBR/EPG) for targeted immunotherapy.	N-Acetylneuraminic Acid	38-49	epithelial mitogen	Homo sapiens	139-149
31108259-3	2019	Herein, we designed and synthesized a sialic acid (SA)-stearic acid conjugate modified on the surface of nanocomplexes to encapsulate IBR (SA/IBR/EPG) for targeted immunotherapy.	N-Acetylneuraminic Acid	51-53	epithelial mitogen	Homo sapiens	139-149
31108259-10	2019	Herein, we designed and synthesized a sialic acid (SA)-stearic acid conjugate modified on the surface of nanocomplexes to encapsulate IBR (SA/IBR/EPG) for targeted delivery of IBR to TAMs.	N-Acetylneuraminic Acid	50-55	epithelial mitogen	Homo sapiens	139-149
31176190-6	2019	We have characterized the steady state kinetics of wild type and mutant variants of Bifidobacterium longum endo-alpha-N-acetylgalactosaminidase, by recording the enzymatic release of Galbeta(1-3)GalNAc from bovine glycomacropeptide pre-treated with sialidase to remove sialic acid units.	N-Acetylneuraminic Acid	269-280	alpha-N-acetylgalactosaminidase	Bos taurus	112-143
31188144-13	2019	Platelet surface sialic acid was increased after PNGase F treatment.	N-Acetylneuraminic Acid	17-28	N-glycanase 1	Homo sapiens	49-55
31055873-2	2019	Terminal sialic acid residues, expressed on both the N- and O-linked glycans of VWF, regulate VWF functional activity, susceptibility to proteolysis and plasma clearance in vivo.	N-Acetylneuraminic Acid	9-20	von Willebrand factor	Homo sapiens	80-83
31055873-10	2019	In contrast, the vast majority of the N-glycans and O-glycans on human VWF are capped by terminal negatively charged sialic acid residues.	N-Acetylneuraminic Acid	117-128	von Willebrand factor	Homo sapiens	71-74
31055873-2	2019	Terminal sialic acid residues, expressed on both the N- and O-linked glycans of VWF, regulate VWF functional activity, susceptibility to proteolysis and plasma clearance in vivo.	N-Acetylneuraminic Acid	9-20	von Willebrand factor	Homo sapiens	94-97
31055873-15	2019	In addition, we consider data suggesting that quantitative and qualitative variations in VWF sialylation may play specific roles in the pathogenesis of VWD, and that sialic acid expression on VWF may also differ across a number of other physiologic and pathologic conditions.	N-Acetylneuraminic Acid	166-177	von Willebrand factor	Homo sapiens	192-195
31073169-6	2019	Similarly, BM cells with a point mutation in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase gene, encoding a key enzyme in sialic acid biosynthesis, showed mildly impaired homing and engraftment abilities.	N-Acetylneuraminic Acid	143-154	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	49-111
31201245-0	2019	Withdrawal: Glycosyl modification facilitates homo- and hetero-oligomerization of the serotonin transporter: a specific role for sialic acid residues.	N-Acetylneuraminic Acid	129-140	solute carrier family 6 member 4	Homo sapiens	86-107
30953118-3	2019	Siglec-3 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family and has been suggested to promote MDSC expansion and suppression.	N-Acetylneuraminic Acid	28-39	CD33 molecule	Homo sapiens	0-8
30953118-10	2019	Interestingly, freshly isolated glioma cells predominantly expressed sialic acid ligands for Siglec-7 and -9, which was confirmed in situ.	N-Acetylneuraminic Acid	69-80	sialic acid binding Ig like lectin 7	Homo sapiens	93-108
31189718-5	2019	We further identified SIGLEC15, a lectin expressed by various immune cells that binds sialic acid-containing structures, as a candidate gene involved in RVVC susceptibility.	N-Acetylneuraminic Acid	86-97	sialic acid binding Ig like lectin 15	Homo sapiens	22-30
31049620-8	2019	Detailed characterizations revealed that decreases in sialic acid content were due either to extracellular sialic acid degradation via hydrolysis of alpha 2-3 sialic acids probably by released cytosolic sialidase or to a lack of galactosylated glycan availability for sialylation during late-stage glycosylation.	N-Acetylneuraminic Acid	54-65	sialidase-2	Cricetulus griseus	193-212
31135625-2	2019	It is caused by a hypomorphic GNE gene, encoding the rate-limiting enzyme in sialic acid synthesis.	N-Acetylneuraminic Acid	77-88	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	30-33
31133698-3	2019	Translocation of CMP-sialic acid into Golgi is carried out by the CMP-sialic acid transporter (CST).	N-Acetylneuraminic Acid	21-32	solute carrier family 35 member A1	Homo sapiens	66-93
31133698-3	2019	Translocation of CMP-sialic acid into Golgi is carried out by the CMP-sialic acid transporter (CST).	N-Acetylneuraminic Acid	21-32	solute carrier family 35 member A1	Homo sapiens	95-98
31133698-7	2019	We conclude that the specificity of CST for CMP-sialic acid is established by the recognition of the nucleotide CMP to such an extent that they are mechanistically capable of both passive and coupled antiporter activity.	N-Acetylneuraminic Acid	48-59	solute carrier family 35 member A1	Homo sapiens	36-39
31115772-1	2019	A high-throughput, dual-channel single cell analytical method is described for the detection of sialic acid (SA) on single cell based on the use of microfluidic droplets integrated with plasmonic imaging and surface-enhanced Raman spectroscopy (SERS) with the assistance of a multifunctional metal nanoparticle-based probe.	N-Acetylneuraminic Acid	96-107	acyl-CoA synthetase medium chain family member 3	Homo sapiens	109-111
31137516-1	2019	The hemagglutinin (HA) and neuraminidase (NA) of influenza A virus possess antagonistic activities on interaction with sialic acid (SA), which is the receptor for virus attachment.	N-Acetylneuraminic Acid	119-130	neuraminidase 1	Homo sapiens	27-40
31137516-1	2019	The hemagglutinin (HA) and neuraminidase (NA) of influenza A virus possess antagonistic activities on interaction with sialic acid (SA), which is the receptor for virus attachment.	N-Acetylneuraminic Acid	132-134	neuraminidase 1	Homo sapiens	27-40
30852321-7	2019	Enzymatic removal of sialic acids results in the removal of galactose residues from the EPS upon subsequent treatment with beta-galactosidase, indicating a linkage between galactose and sialic acid at the terminus of glycan chains.	N-Acetylneuraminic Acid	21-32	galactosidase beta 1	Homo sapiens	123-141
31143186-5	2019	Two inhibitory sialic acid-binding immunoglobulin-like lectin (Siglec) receptors are expressed by NK cells: Siglec-7 and Siglec-9.	N-Acetylneuraminic Acid	15-26	sialic acid binding Ig like lectin 7	Homo sapiens	108-116
31143186-5	2019	Two inhibitory sialic acid-binding immunoglobulin-like lectin (Siglec) receptors are expressed by NK cells: Siglec-7 and Siglec-9.	N-Acetylneuraminic Acid	15-26	sialic acid binding Ig like lectin 9	Homo sapiens	121-129
30797170-5	2019	Treatment of WT 5XFAD mice with the sialic acid-specific Limax flavus agglutinin resulted in substantial improvement of AD pathology to a level of ST3-/- 5XFAD mice.	N-Acetylneuraminic Acid	36-47	matrix metallopeptidase 11	Mus musculus	147-150
31064828-4	2019	More importantly, recognition of sialylated RNA viruses or sialic acid mimics by NMHC-IIA was shown to inhibit lipopolysaccharide (LPS)-induced proinflammatory responses via the DAP12-Syk pathway.	N-Acetylneuraminic Acid	59-70	myosin heavy chain 9	Homo sapiens	81-89
31064828-4	2019	More importantly, recognition of sialylated RNA viruses or sialic acid mimics by NMHC-IIA was shown to inhibit lipopolysaccharide (LPS)-induced proinflammatory responses via the DAP12-Syk pathway.	N-Acetylneuraminic Acid	59-70	transmembrane immune signaling adaptor TYROBP	Homo sapiens	178-183
31064828-4	2019	More importantly, recognition of sialylated RNA viruses or sialic acid mimics by NMHC-IIA was shown to inhibit lipopolysaccharide (LPS)-induced proinflammatory responses via the DAP12-Syk pathway.	N-Acetylneuraminic Acid	59-70	spleen associated tyrosine kinase	Homo sapiens	184-187
31064828-10	2019	More importantly, sialic acid mimics and sialylated RNA viruses enable the antagonism of LPS-triggered proinflammatory responses through engaging the NMHC-IIA-DAP12-Syk pathway.	N-Acetylneuraminic Acid	18-29	myosin heavy chain 9	Homo sapiens	150-158
31064828-10	2019	More importantly, sialic acid mimics and sialylated RNA viruses enable the antagonism of LPS-triggered proinflammatory responses through engaging the NMHC-IIA-DAP12-Syk pathway.	N-Acetylneuraminic Acid	18-29	transmembrane immune signaling adaptor TYROBP	Homo sapiens	159-164
31064828-10	2019	More importantly, sialic acid mimics and sialylated RNA viruses enable the antagonism of LPS-triggered proinflammatory responses through engaging the NMHC-IIA-DAP12-Syk pathway.	N-Acetylneuraminic Acid	18-29	spleen associated tyrosine kinase	Homo sapiens	165-168
30641224-9	2019	Relative abundances of several N-glycan structures were dramatically altered by the neuraminidase treatment, which selectively removed sialic acid residues.	N-Acetylneuraminic Acid	135-146	neuraminidase 1	Homo sapiens	84-97
30993977-5	2019	Proof-of-concept protocols have been developed for the imaging of MUC1-bound terminal sialic acid and fucose.	N-Acetylneuraminic Acid	86-97	mucin 1, cell surface associated	Homo sapiens	66-70
30842877-0	2019	Serum IgA1 shows increased levels of alpha2,6-linked sialic acid in breast cancer.	N-Acetylneuraminic Acid	53-64	immunoglobulin heavy constant alpha 1	Homo sapiens	6-10
31036580-0	2019	A phase 3 randomized study evaluating sialic acid extended-release for GNE myopathy.	N-Acetylneuraminic Acid	38-49	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	71-74
30979549-0	2019	Force Spectroscopy Shows Dynamic Binding of Influenza Hemagglutinin and Neuraminidase to Sialic Acid.	N-Acetylneuraminic Acid	89-100	neuraminidase 1	Homo sapiens	72-85
30808675-2	2019	One such target is the oncodevelopmental antigen polysialic acid (polySia), a polymer of alpha2,8-linked sialic acid residues that is largely absent during postnatal development but is re-expressed during progression of several malignant human tumors, including small-cell and non-small cell lung carcinomas, glioma, neuroblastoma, and pancreatic carcinoma.	N-Acetylneuraminic Acid	53-64	immunoglobulin kappa variable 2-19 (pseudogene)	Homo sapiens	89-97
31134048-4	2019	In all cases, loss-of-function mutations in the gene encoding the sialic acid-modifying enzyme CMAH are responsible for the drastic change in these species.	N-Acetylneuraminic Acid	66-77	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	95-99
30985278-4	2019	Here we present the first crystal structures of a mammalian NST, the mouse CMP-sialic acid transporter (mCST), in complex with its physiological substrates CMP and CMP-sialic acid.	N-Acetylneuraminic Acid	79-90	cortistatin	Mus musculus	104-108
30963312-6	2019	The sensor can well differentiate SA from its analogs at physiological pH values and has a linear potentiometric response (R2 = 0.998) in 80 muM to 8.2 mM SA concentrations range with a detection limit of 60 muM (at S/N = 3).	N-Acetylneuraminic Acid	34-36	latexin	Homo sapiens	141-144
30963312-6	2019	The sensor can well differentiate SA from its analogs at physiological pH values and has a linear potentiometric response (R2 = 0.998) in 80 muM to 8.2 mM SA concentrations range with a detection limit of 60 muM (at S/N = 3).	N-Acetylneuraminic Acid	34-36	latexin	Homo sapiens	208-211
30963312-6	2019	The sensor can well differentiate SA from its analogs at physiological pH values and has a linear potentiometric response (R2 = 0.998) in 80 muM to 8.2 mM SA concentrations range with a detection limit of 60 muM (at S/N = 3).	N-Acetylneuraminic Acid	155-157	latexin	Homo sapiens	141-144
30963312-6	2019	The sensor can well differentiate SA from its analogs at physiological pH values and has a linear potentiometric response (R2 = 0.998) in 80 muM to 8.2 mM SA concentrations range with a detection limit of 60 muM (at S/N = 3).	N-Acetylneuraminic Acid	155-157	latexin	Homo sapiens	208-211
31019513-7	2019	To this end, we mutated five out of the six N-linked glycosylation residues on CD22 localized closest to the sialic acid binding site.	N-Acetylneuraminic Acid	109-120	CD22 molecule	Homo sapiens	79-83
30658806-5	2019	The interaction between the molecules could be inhibited by an antibody against lactoferricin (LFcin), which suggests that the LFcin domain of lactoferrin represents the potential binding area for sialic acid polymers.	N-Acetylneuraminic Acid	197-208	lactotransferrin	Homo sapiens	127-132
30926758-0	2019	Expression of Concern: Glycosyl modification facilitates homo- and hetero-oligomerization of the serotonin transporter: A specific role for sialic acid residues.	N-Acetylneuraminic Acid	140-151	solute carrier family 6 member 4	Homo sapiens	97-118
30720809-3	2019	Through confocal laser scanning microscopy and flow cytometry analysis, PPP-mediated cellular uptake of miR-34a was found to proceed through a sialic acid-dependent endocytosis pathway and the nanoparticles could achieve endosome/lysosome escape within 6 h. Further, an anti-proliferative effect could be obtained after PPP/miR-34a transfection through the induction of cell apoptosis.	N-Acetylneuraminic Acid	143-154	microRNA 34a	Homo sapiens	104-111
30658806-5	2019	The interaction between the molecules could be inhibited by an antibody against lactoferricin (LFcin), which suggests that the LFcin domain of lactoferrin represents the potential binding area for sialic acid polymers.	N-Acetylneuraminic Acid	197-208	lactotransferrin	Homo sapiens	80-93
30658806-5	2019	The interaction between the molecules could be inhibited by an antibody against lactoferricin (LFcin), which suggests that the LFcin domain of lactoferrin represents the potential binding area for sialic acid polymers.	N-Acetylneuraminic Acid	197-208	lactotransferrin	Homo sapiens	95-100
30899760-6	2019	Also, we assort literature suggesting the association of Thy-1 with specific components of lipid rafts such as sialic acid containing glycosphingolipids, called gangliosides.	N-Acetylneuraminic Acid	111-122	Thy-1 cell surface antigen	Homo sapiens	57-62
30849118-7	2019	Sialic acid on the platelet membrane is neuraminidase-labile, but dengue virus has no known neuraminidase activity.	N-Acetylneuraminic Acid	0-11	neuraminidase 1	Homo sapiens	40-53
30849118-10	2019	In contrast, induction of binding of VWF to glycoprotein 1b on platelets using the VWF-activating protein ristocetin resulted in the removal of platelet sialic acid by translocation of platelet neuraminidase to the platelet surface.	N-Acetylneuraminic Acid	153-164	von Willebrand factor	Homo sapiens	37-40
30849118-10	2019	In contrast, induction of binding of VWF to glycoprotein 1b on platelets using the VWF-activating protein ristocetin resulted in the removal of platelet sialic acid by translocation of platelet neuraminidase to the platelet surface.	N-Acetylneuraminic Acid	153-164	von Willebrand factor	Homo sapiens	83-86
30849118-10	2019	In contrast, induction of binding of VWF to glycoprotein 1b on platelets using the VWF-activating protein ristocetin resulted in the removal of platelet sialic acid by translocation of platelet neuraminidase to the platelet surface.	N-Acetylneuraminic Acid	153-164	neuraminidase 1	Homo sapiens	194-207
30862964-1	2019	N-glycolylneuraminic acid (Neu5Gc), a generic form of sialic acid, is enzymatically synthesized by cytidine-5"-monophospho-N-acetylneuraminic acid hydroxylase (CMAH).	N-Acetylneuraminic Acid	54-65	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Sus scrofa	99-158
30862964-1	2019	N-glycolylneuraminic acid (Neu5Gc), a generic form of sialic acid, is enzymatically synthesized by cytidine-5"-monophospho-N-acetylneuraminic acid hydroxylase (CMAH).	N-Acetylneuraminic Acid	54-65	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Sus scrofa	160-164
30394319-1	2019	The serotonin transporter (SERT) is an oligomeric glycoprotein with two sialic acid residues on each of two complex oligosaccharide molecules.	N-Acetylneuraminic Acid	72-83	solute carrier family 6 member 4	Homo sapiens	4-25
30597004-2	2019	We observed a complete loss of 9-O-acetylation of sialic acid on the surface of myeloid, erythroid and CD4+ T cells in Casd1-deficient mice.	N-Acetylneuraminic Acid	50-61	CAS1 domain containing 1	Mus musculus	119-124
30597004-5	2019	The sialic acid glyco-epitope recognized by TER-119 on erythrocytes was sensitive to the sialic acid O-acetyl esterase activity of the hemagglutinin-esterase from bovine coronavirus but not to the corresponding enzyme from the influenza C virus.	N-Acetylneuraminic Acid	4-15	lymphocyte antigen 76	Mus musculus	44-51
30847305-8	2019	After neuraminidase pre-treatment, which catalyzes the hydrolysis of terminal sialic acid residues, AML cells were less sensitive to WGA-induced cell death.	N-Acetylneuraminic Acid	78-89	neuraminidase 1	Homo sapiens	6-19
30610060-4	2019	We show that dectin-1 and MR are critical for the recognition of tumor cells through sialic acid-specific glycan structure on their surface and for the subsequent activation of macrophage tumoricidal response.	N-Acetylneuraminic Acid	85-96	C-type lectin domain containing 7A	Homo sapiens	13-21
30481010-0	2019	Comparative Binding Analysis of N-Acetylneuraminic Acid in Bovine Serum Albumin and Human alpha-1 Acid Glycoprotein.	N-Acetylneuraminic Acid	32-55	albumin	Homo sapiens	66-79
30481010-1	2019	The present study focuses on the determination of the biologically significant N-acetylneuraminic acid (NANA) drug binding interaction mechanism between bovine serum albumin (BSA) and human alpha-1 acid glycoprotein (HAG) using various optical spectroscopy and computational methods.	N-Acetylneuraminic Acid	79-102	albumin	Homo sapiens	160-173
30709055-1	2019	The mammalian mono-alpha2,8-sialyltransferase ST8Sia VI has been shown to catalyze the transfer of a unique sialic acid residues onto core 1 O-glycans leading to the formation of di-sialylated O-glycosylproteins and to a lesser extent to diSia motifs onto glycolipids like GD1a.	N-Acetylneuraminic Acid	108-119	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	Homo sapiens	46-55
30700826-3	2019	Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans.	N-Acetylneuraminic Acid	107-118	tumor protein p73	Homo sapiens	19-22
30700826-3	2019	Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans.	N-Acetylneuraminic Acid	107-118	transcription factor AP-2 alpha	Homo sapiens	27-30
30700826-3	2019	Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans.	N-Acetylneuraminic Acid	107-118	neuraminidase 4	Homo sapiens	52-56
30700826-3	2019	Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans.	N-Acetylneuraminic Acid	107-118	neuraminidase 1	Homo sapiens	60-73
30394319-1	2019	The serotonin transporter (SERT) is an oligomeric glycoprotein with two sialic acid residues on each of two complex oligosaccharide molecules.	N-Acetylneuraminic Acid	72-83	solute carrier family 6 member 4	Homo sapiens	27-31
30554660-7	2019	Moreover, C1Inh-His produced by Lec2 mutant cells (deficient in sialic acid biosynthesis) showed much lower binding affinity for SSL5 than that produced by the wild-type CHO-K1 cells, as assessed by pull-down assay.	N-Acetylneuraminic Acid	64-75	serpin family G member 1	Homo sapiens	10-19
30554660-8	2019	These results suggest that SSL5 binds to C1Inh in a sialic acid-dependent fashion and modulates the host immune defense through perturbation of the complement system in association with S. aureus infection.	N-Acetylneuraminic Acid	52-63	serpin family G member 1	Homo sapiens	41-46
30898036-7	2019	Huh7 cells deficient in alpha2,3-linked sialic acid through knockout of ST3 beta-galactoside-alpha2,3-sialyltransferase 4 had significantly reduced ZIKV infection.	N-Acetylneuraminic Acid	40-51	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	72-121
30616506-2	2019	However, mouse and human are different in sialylation patterns of proteins due to evolutionary mutations of the CMP-N-acetylneuraminic acid hydroxylase (CMAH) gene that prevent formation of N-glycolylneuraminic acid from N-acetylneuraminic acid.	N-Acetylneuraminic Acid	116-139	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	153-157
30848200-6	2019	Currently, sialyltransferases, mainly ST6Gal I, are regarded as major contributors to sialic acid metabolism in human blood.	N-Acetylneuraminic Acid	86-97	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	38-46
30431285-4	2019	The results manifest that with the increase of microsphere, lung distribution of microsphere is also increased in murine mice, and after SA modification, the microsphere exhibits the ideal lung-targeted characteristic in ALI model mice, due to SA efficiently targeting to E-selectin expressed on inflammatory tissues.	N-Acetylneuraminic Acid	137-139	selectin, endothelial cell	Mus musculus	272-282
30431285-4	2019	The results manifest that with the increase of microsphere, lung distribution of microsphere is also increased in murine mice, and after SA modification, the microsphere exhibits the ideal lung-targeted characteristic in ALI model mice, due to SA efficiently targeting to E-selectin expressed on inflammatory tissues.	N-Acetylneuraminic Acid	244-246	selectin, endothelial cell	Mus musculus	272-282
30905461-2	2019	Sialic acid (SA) generally occurs as the terminal monosaccharide on the glycans.	N-Acetylneuraminic Acid	0-11	acyl-CoA synthetase medium chain family member 3	Homo sapiens	13-15
30390020-1	2019	GNE myopathy is a rare autosomal recessive distal myopathy caused by mutations in UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the bi-functional enzyme critical for sialic acid biosynthesis.	N-Acetylneuraminic Acid	190-201	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
30390020-1	2019	GNE myopathy is a rare autosomal recessive distal myopathy caused by mutations in UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the bi-functional enzyme critical for sialic acid biosynthesis.	N-Acetylneuraminic Acid	190-201	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	82-144
30280189-8	2018	Furthermore, neuraminidase treatment, which removes negatively charged sialic acid from the cell surface, markedly reduced the internalization of LL-37 and degranulation of LAD2 cells, and clathrin-mediated endocytosis inhibitors (dynasore and chlorpromazine) inhibited the internalization and degranulation of LAD2 cells.	N-Acetylneuraminic Acid	71-82	neuraminidase 1	Homo sapiens	13-26
30446565-0	2018	Sialic Acid-Dependent Inhibition of T Cells by Exosomal Ganglioside GD3 in Ovarian Tumor Microenvironments.	N-Acetylneuraminic Acid	0-11	GRDX	Homo sapiens	68-71
30446565-6	2018	Finally, we demonstrate that the GD3-mediated arrest of the TCR activation is dependent upon sialic acid groups, because their enzymatic removal from exosomes or liposomes results in a loss of inhibitory capacity.	N-Acetylneuraminic Acid	93-104	GRDX	Homo sapiens	33-36
30340996-8	2018	Moreover, we could demonstrate by HPTLC analyses that recombinant Bacteroides thetaiotaomicron sialidase (BTSA-His) was able to cleave Neu5Ac and Neu5,9Ac2 from BSM and that the combination of BTSA-His with both NanS-His and NanS-p-His derivatives enhanced the release of de-O-acetylated core Neu5Ac and Neu5Gc from mammalian mucin O-glycans.	N-Acetylneuraminic Acid	135-141	N-acetylneuraminate synthase	Bos taurus	212-216
30340996-8	2018	Moreover, we could demonstrate by HPTLC analyses that recombinant Bacteroides thetaiotaomicron sialidase (BTSA-His) was able to cleave Neu5Ac and Neu5,9Ac2 from BSM and that the combination of BTSA-His with both NanS-His and NanS-p-His derivatives enhanced the release of de-O-acetylated core Neu5Ac and Neu5Gc from mammalian mucin O-glycans.	N-Acetylneuraminic Acid	135-141	N-acetylneuraminate synthase	Bos taurus	225-229
30568043-0	2018	Sialic acid catabolism by N-acetylneuraminate pyruvate lyase is essential for muscle function.	N-Acetylneuraminic Acid	0-11	N-acetylneuraminate pyruvate lyase	Homo sapiens	26-60
30542051-7	2018	Interestingly, in an in vivo mouse endometriosis model, inhibition of endogenous sialic acid binding by a NeuAcalpha2-6Galbeta1-4GlcNAc injection diminished TGF-beta1-induced formation of endometriosis lesions.	N-Acetylneuraminic Acid	81-92	transforming growth factor, beta 1	Mus musculus	157-166
30564250-3	2018	A type of sialic acid called N-glycolylneuraminic acid (Neu5Gc) is abundant in many mammalian lineages including great apes, the closest extant relatives of modern human, but was lost in the lineage leading to modern human via the pseudogenization of the CMAH gene encoding the enzyme that converts N-acetylneuraminic acid (Neu5Ac) to Neu5Gc.	N-Acetylneuraminic Acid	10-21	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	255-259
30340996-6	2018	The nanoESI MS analysis of neuraminic acids after treatment of BSM with NanS-p gave evidence that NanS-p variants of EHEC O157:H7 strain EDL933 cleave off O-acetyl groups from mono-, di-, and tri-O-acetylated Neu5Ac and N-glycolylneuraminic acid (Neu5Gc), regardless of the carbon positions C7, C8 or C9 of the acetate esters.	N-Acetylneuraminic Acid	209-215	N-acetylneuraminate synthase	Bos taurus	72-76
30340996-6	2018	The nanoESI MS analysis of neuraminic acids after treatment of BSM with NanS-p gave evidence that NanS-p variants of EHEC O157:H7 strain EDL933 cleave off O-acetyl groups from mono-, di-, and tri-O-acetylated Neu5Ac and N-glycolylneuraminic acid (Neu5Gc), regardless of the carbon positions C7, C8 or C9 of the acetate esters.	N-Acetylneuraminic Acid	209-215	N-acetylneuraminate synthase	Bos taurus	98-102
30280189-8	2018	Furthermore, neuraminidase treatment, which removes negatively charged sialic acid from the cell surface, markedly reduced the internalization of LL-37 and degranulation of LAD2 cells, and clathrin-mediated endocytosis inhibitors (dynasore and chlorpromazine) inhibited the internalization and degranulation of LAD2 cells.	N-Acetylneuraminic Acid	71-82	cathelicidin antimicrobial peptide	Homo sapiens	146-151
29603642-5	2018	Furthermore, we provide data that show that reactivity to the sialic acid Neu5Gc is a common finding among samples that are highest in anti-AT1R levels.	N-Acetylneuraminic Acid	62-73	angiotensin II receptor type 1	Homo sapiens	140-144
30371703-1	2018	Based on the overproduction of matrix metalloproteinase-2 (MMP-2) in renal tissue during acute kidney injury (AKI) occurrence, we developed a MMP-2 enzyme-triggered polymeric prodrug with sialic acid (SA) as the targeting group to the inflamed vascular endothelial cells for enhanced therapeutic outcomes.	N-Acetylneuraminic Acid	188-199	matrix metallopeptidase 2	Mus musculus	31-57
30371703-1	2018	Based on the overproduction of matrix metalloproteinase-2 (MMP-2) in renal tissue during acute kidney injury (AKI) occurrence, we developed a MMP-2 enzyme-triggered polymeric prodrug with sialic acid (SA) as the targeting group to the inflamed vascular endothelial cells for enhanced therapeutic outcomes.	N-Acetylneuraminic Acid	188-199	matrix metallopeptidase 2	Mus musculus	59-64
30371703-1	2018	Based on the overproduction of matrix metalloproteinase-2 (MMP-2) in renal tissue during acute kidney injury (AKI) occurrence, we developed a MMP-2 enzyme-triggered polymeric prodrug with sialic acid (SA) as the targeting group to the inflamed vascular endothelial cells for enhanced therapeutic outcomes.	N-Acetylneuraminic Acid	188-199	matrix metallopeptidase 2	Mus musculus	142-147
30371703-1	2018	Based on the overproduction of matrix metalloproteinase-2 (MMP-2) in renal tissue during acute kidney injury (AKI) occurrence, we developed a MMP-2 enzyme-triggered polymeric prodrug with sialic acid (SA) as the targeting group to the inflamed vascular endothelial cells for enhanced therapeutic outcomes.	N-Acetylneuraminic Acid	201-203	matrix metallopeptidase 2	Mus musculus	31-57
30371703-1	2018	Based on the overproduction of matrix metalloproteinase-2 (MMP-2) in renal tissue during acute kidney injury (AKI) occurrence, we developed a MMP-2 enzyme-triggered polymeric prodrug with sialic acid (SA) as the targeting group to the inflamed vascular endothelial cells for enhanced therapeutic outcomes.	N-Acetylneuraminic Acid	201-203	matrix metallopeptidase 2	Mus musculus	59-64
30371703-1	2018	Based on the overproduction of matrix metalloproteinase-2 (MMP-2) in renal tissue during acute kidney injury (AKI) occurrence, we developed a MMP-2 enzyme-triggered polymeric prodrug with sialic acid (SA) as the targeting group to the inflamed vascular endothelial cells for enhanced therapeutic outcomes.	N-Acetylneuraminic Acid	201-203	matrix metallopeptidase 2	Mus musculus	142-147
30371703-6	2018	A cellular uptake test confirmed that SA-DEX-PVGLIG-CUR was effectively internalized by inflamed vascular endothelial cells in comparison with that by normal cells, and the mechanism was associated with the specific interaction between SA and E-selectin receptors specifically expressed on inflamed vascular endothelial cells.	N-Acetylneuraminic Acid	38-40	selectin, endothelial cell	Mus musculus	243-253
30220337-6	2018	Since the sialic acids are considered as ligands of L-selectin, we propose that leukocytes bind to the sperm through the L-selectin on leukocytes and sialic acid on sperm surface during the sperm phagocytosis in female reproductive tract.	N-Acetylneuraminic Acid	10-21	selectin L	Homo sapiens	52-62
30130255-3	2018	CD33-related sialic acid-binding immunoglobulin-like lectins (Siglecs) are pattern-recognition immune receptors binding to a range of sialoglycan ligands, which appear to function as self-associated molecular patterns (SAMPs) that suppress autoimmune responses.	N-Acetylneuraminic Acid	13-24	CD33 molecule	Homo sapiens	0-4
30220337-6	2018	Since the sialic acids are considered as ligands of L-selectin, we propose that leukocytes bind to the sperm through the L-selectin on leukocytes and sialic acid on sperm surface during the sperm phagocytosis in female reproductive tract.	N-Acetylneuraminic Acid	10-21	selectin L	Homo sapiens	121-131
30374284-3	2018	Individuals with mutations in presenilin or amyloid precursor protein (APP) gene develop AD while mutations in GNE (UDP N-acetylglucosamine 2 epimerase/N-acetyl Mannosamine kinase), key sialic acid biosynthesis enzyme, cause GNEM.	N-Acetylneuraminic Acid	186-197	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	111-114
29785832-6	2018	RESULTS: SNA-I, a lectin binding preferentially to alpha2-6 linked sialic acid residues, shows higher binding signals (near 42 kDa) in the mycoplasma pneumonia group, when compared with the other groups.	N-Acetylneuraminic Acid	67-78	immunoglobulin binding protein 1	Homo sapiens	51-59
30375371-3	2018	ST3GAL1 is a sialyltransferase that catalyzes the transfer of sialic acid from cytidine monophosphate-sialic acid to galactose-containing substrates and is associated with cancer progression and chemoresistance.	N-Acetylneuraminic Acid	62-73	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	0-7
30375371-3	2018	ST3GAL1 is a sialyltransferase that catalyzes the transfer of sialic acid from cytidine monophosphate-sialic acid to galactose-containing substrates and is associated with cancer progression and chemoresistance.	N-Acetylneuraminic Acid	62-73	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	13-30
30375371-3	2018	ST3GAL1 is a sialyltransferase that catalyzes the transfer of sialic acid from cytidine monophosphate-sialic acid to galactose-containing substrates and is associated with cancer progression and chemoresistance.	N-Acetylneuraminic Acid	102-113	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	0-7
30375371-3	2018	ST3GAL1 is a sialyltransferase that catalyzes the transfer of sialic acid from cytidine monophosphate-sialic acid to galactose-containing substrates and is associated with cancer progression and chemoresistance.	N-Acetylneuraminic Acid	102-113	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	13-30
30374284-3	2018	Individuals with mutations in presenilin or amyloid precursor protein (APP) gene develop AD while mutations in GNE (UDP N-acetylglucosamine 2 epimerase/N-acetyl Mannosamine kinase), key sialic acid biosynthesis enzyme, cause GNEM.	N-Acetylneuraminic Acid	186-197	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	116-179
30235335-3	2018	Cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts N-acetylneuraminic acid (type B) to N-glycolylneuraminic acid (type A), and type C erythrocytes express both antigens.	N-Acetylneuraminic Acid	23-46	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Felis catus	60-64
30277651-2	2018	To facilitate the clinical application of LEA, we identified LEA as a podocalyxin-like protein 1 (PODXL) with molecular weight of approximately 230 kDa, a hyperglycosylated protein, using immunoprecipitation and mass spectrometry in combination, and verified that ND-1-recognized epitope is on the terminal sialic acid of LEA.	N-Acetylneuraminic Acid	307-318	podocalyxin like	Homo sapiens	70-96
30277651-2	2018	To facilitate the clinical application of LEA, we identified LEA as a podocalyxin-like protein 1 (PODXL) with molecular weight of approximately 230 kDa, a hyperglycosylated protein, using immunoprecipitation and mass spectrometry in combination, and verified that ND-1-recognized epitope is on the terminal sialic acid of LEA.	N-Acetylneuraminic Acid	307-318	podocalyxin like	Homo sapiens	98-103
29982679-0	2018	Biophysical analysis of sialic acid recognition by the complement regulator Factor H.	N-Acetylneuraminic Acid	24-35	complement factor H	Homo sapiens	76-84
29982679-2	2018	It contains several glycan binding sites which mediate recognition of alpha2-3-linked sialic acid (FH domain 20) and glycosaminoglycans (domains 6-8 and 19-20).	N-Acetylneuraminic Acid	86-97	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	70-78
29982679-4	2018	In freely circulating FH the C3b binding site in domains 19-20 is occluded, a phenomenon that is not fully understood and could be mediated by an intramolecular interaction between FH"s intrinsic sialylated glycosylation and its own sialic acid binding site.	N-Acetylneuraminic Acid	233-244	complement factor H	Homo sapiens	22-24
29982679-4	2018	In freely circulating FH the C3b binding site in domains 19-20 is occluded, a phenomenon that is not fully understood and could be mediated by an intramolecular interaction between FH"s intrinsic sialylated glycosylation and its own sialic acid binding site.	N-Acetylneuraminic Acid	233-244	complement C3	Homo sapiens	29-32
29982679-4	2018	In freely circulating FH the C3b binding site in domains 19-20 is occluded, a phenomenon that is not fully understood and could be mediated by an intramolecular interaction between FH"s intrinsic sialylated glycosylation and its own sialic acid binding site.	N-Acetylneuraminic Acid	233-244	complement factor H	Homo sapiens	181-183
29982679-5	2018	In order to assess this possibility, we characterized FH"s sialylation with respect to glycosidic linkage type and searched for further potential, not yet characterized sialic acid binding sites in FH and its seven-domain spanning splice variant and fellow complement regulator FH like-1 (FHL-1).	N-Acetylneuraminic Acid	169-180	complement factor H	Homo sapiens	198-200
29982679-6	2018	We also probed FH binding to the sialic acid variant Neu5Gc which is not expressed in humans but on heterologous erythrocytes that restrict the human AP and in FH transgenic mice.	N-Acetylneuraminic Acid	33-44	complement factor H	Homo sapiens	15-17
29982679-7	2018	We find that FH contains mostly alpha2-6-linked sialic acid, making an intramolecular interaction with its alpha2-3-sialic acid specific binding site and an associated self-lock mechanism unlikely, substantiate that there is only a single sialic acid binding site in FH and none in FHL-1, and demonstrate direct binding of FH to the nonhuman sialic acid Neu5Gc, supporting the use of FH transgenic mouse models for studies of complement-related diseases.	N-Acetylneuraminic Acid	48-59	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	32-40
30349315-6	2018	Loss of Neu5Ac by enzymatic removal or siRNA knockdown of cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS), which activates cellular sialic acids for glycoprotein conjugation, had no significant effect on cell proliferation, but decreased the ability of BPLER to invade through a basement membrane.	N-Acetylneuraminic Acid	8-14	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	58-115
30349315-6	2018	Loss of Neu5Ac by enzymatic removal or siRNA knockdown of cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS), which activates cellular sialic acids for glycoprotein conjugation, had no significant effect on cell proliferation, but decreased the ability of BPLER to invade through a basement membrane.	N-Acetylneuraminic Acid	8-14	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	117-121
30143587-0	2018	Sialic Acid Ligand Binding of CD22 and Siglec-G Determines Distinct B Cell Functions but Is Dispensable for B Cell Tolerance Induction.	N-Acetylneuraminic Acid	0-11	CD22 antigen	Mus musculus	30-34
30039903-4	2018	A proof-of-concept protocol has been developed for MUC1-specific imaging of terminal sialic acid (Sia) and fucose (Fuc) on MCF-7, T47D, MDA-MB-231, and PANC-1 cells, revealing distinct monosaccharide patterns for four types of cells.	N-Acetylneuraminic Acid	85-96	mucin 1, cell surface associated	Homo sapiens	51-55
30039903-4	2018	A proof-of-concept protocol has been developed for MUC1-specific imaging of terminal sialic acid (Sia) and fucose (Fuc) on MCF-7, T47D, MDA-MB-231, and PANC-1 cells, revealing distinct monosaccharide patterns for four types of cells.	N-Acetylneuraminic Acid	98-101	mucin 1, cell surface associated	Homo sapiens	51-55
29787815-7	2018	These results indicated that B. bifidum SiaBb2 liberated sialic acid from sialyl-human milk oligosaccharides and -mucin glycans, supporting the growth of B. breve through sialic acid cross-feeding.	N-Acetylneuraminic Acid	171-182	LOC100508689	Homo sapiens	114-119
30030221-10	2018	Furthermore, we showed that two analogous Ig-like subdomains of SssP1 have sialic acid binding capacities.	N-Acetylneuraminic Acid	75-86	chromosome 5 open reading frame 46	Homo sapiens	64-69
30071025-6	2018	Additionally, we employed a novel gene-edited CHO cell line (MGAT1- CHO) to address the problems of high sialic acid content, and poor antigenic structure.	N-Acetylneuraminic Acid	105-116	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Cricetulus griseus	61-66
29983395-3	2018	To develop new strategies and therapies for HIV-1/AIDS, we tested if the CD24 and Fc fusion protein (CD24Fc), which interacts with danger-associated molecular patterns and sialic acid binding Ig-like lectin to attenuate inflammation, can protect Chinese rhesus macaques (ChRMs) with SIV infection.	N-Acetylneuraminic Acid	172-183	CD24 molecule	Homo sapiens	73-77
30015474-4	2018	We demonstrate that these CMP-Neu5Ac mimetics inhibit polysialylation in vitro and perform cell culture experiments, where we observe reduced polysialylation of NCAM.	N-Acetylneuraminic Acid	30-36	neural cell adhesion molecule 1	Homo sapiens	161-165
29619625-9	2018	Further, sialic acid residues of VWF may exert a protective effect against post-translational glycosylation.	N-Acetylneuraminic Acid	9-20	von Willebrand factor	Homo sapiens	33-36
30054538-10	2018	Partial cleavage of sialic acid residues was found to boost the inflammatory response of microglia to PrPSc.	N-Acetylneuraminic Acid	20-31	prion protein	Mus musculus	102-107
29903053-2	2018	In this study, N-acetylneuraminic acid functionalized quantum dots nanoconjugate was synthesized and used for targeting and fluorescence imaging of CD22 on living cells.	N-Acetylneuraminic Acid	15-38	CD22 molecule	Homo sapiens	148-152
29951070-9	2018	In contrast, surfactant protein A, ficolins, and other inhibitors present sialic acid rich ligands to which the HA can bind.	N-Acetylneuraminic Acid	74-85	surfactant protein A1	Homo sapiens	13-33
29997173-3	2018	CD52-Fc bound specifically to the proinflammatory Box B domain of HMGB1, and this in turn promoted binding of the CD52 N-linked glycan, in alpha-2,3 sialic acid linkage with galactose, to Siglec-10.	N-Acetylneuraminic Acid	149-160	CD52 molecule	Homo sapiens	0-4
29997173-3	2018	CD52-Fc bound specifically to the proinflammatory Box B domain of HMGB1, and this in turn promoted binding of the CD52 N-linked glycan, in alpha-2,3 sialic acid linkage with galactose, to Siglec-10.	N-Acetylneuraminic Acid	149-160	high mobility group box 1	Homo sapiens	66-71
29997173-3	2018	CD52-Fc bound specifically to the proinflammatory Box B domain of HMGB1, and this in turn promoted binding of the CD52 N-linked glycan, in alpha-2,3 sialic acid linkage with galactose, to Siglec-10.	N-Acetylneuraminic Acid	149-160	CD52 molecule	Homo sapiens	114-118
29997173-3	2018	CD52-Fc bound specifically to the proinflammatory Box B domain of HMGB1, and this in turn promoted binding of the CD52 N-linked glycan, in alpha-2,3 sialic acid linkage with galactose, to Siglec-10.	N-Acetylneuraminic Acid	149-160	sialic acid binding Ig like lectin 10	Homo sapiens	188-197
29764940-0	2018	The tetrameric structure of sialic acid-synthesizing UDP-GlcNAc 2-epimerase from Acinetobacter baumannii: A comparative study with human GNE.	N-Acetylneuraminic Acid	28-39	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	137-140
29764940-8	2018	NeuC lacks the CMP-Neu5Ac-binding site for allosteric inhibition of GNE.	N-Acetylneuraminic Acid	19-25	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	68-71
30317754-1	2018	Objective: To explore the relationship between sialic-acid-binding immunoglobulin-like lectin 7 (Siglec-7) expressed on NK cells and hepatitis B virus-related cirrhosis.	N-Acetylneuraminic Acid	47-58	sialic acid binding Ig like lectin 7	Homo sapiens	97-105
29844237-3	2018	Ongoing work has shown that growth of 15253 in cytidine monophospho-N-acetylneuraminic acid (CMP-Neu5Ac)-containing medium enables binding to CD33/Siglec-3, a cell surface receptor that binds sialic acid, suggesting that lactose termini on LOSs of intact gonococci can be sialylated.	N-Acetylneuraminic Acid	192-203	CD33 antigen	Mus musculus	142-146
29844237-3	2018	Ongoing work has shown that growth of 15253 in cytidine monophospho-N-acetylneuraminic acid (CMP-Neu5Ac)-containing medium enables binding to CD33/Siglec-3, a cell surface receptor that binds sialic acid, suggesting that lactose termini on LOSs of intact gonococci can be sialylated.	N-Acetylneuraminic Acid	192-203	CD33 antigen	Mus musculus	147-155
29844237-5	2018	Resistance of HepII lactose Neu5Ac to desialylation by alpha2-3-specific neuraminidase suggested an alpha2-6 linkage.	N-Acetylneuraminic Acid	28-34	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	100-108
30018219-5	2018	The analysis of Drosophila EGF20 expressed in HEK293T cells revealed that the majority of the proteins are modified with an elongated form of O-GlcNAc glycan comprising terminal galactose or sialic acid residues.	N-Acetylneuraminic Acid	191-202	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	142-150
29703719-4	2018	Sialic acid blockade had a major impact on the immune cell composition of the tumor, enhancing tumor-infiltrating natural killer cell and CD8+ T-cell numbers while reducing regulatory T-cell and myeloid regulatory cell numbers.	N-Acetylneuraminic Acid	0-11	CD8a molecule	Homo sapiens	138-141
29703719-5	2018	Sialic acid blockade enhanced cytotoxic CD8+ T-cell-mediated killing of tumor cells in part by facilitating antigen-specific T-cell-tumor cell clustering.	N-Acetylneuraminic Acid	0-11	CD8a molecule	Homo sapiens	40-43
29703719-6	2018	Sialic acid blockade also synergized with adoptive transfer of tumor-specific CD8+ T cells in vivo and enhanced CpG immune adjuvant therapy by increasing dendritic cell activation and subsequent CD8+ T-cell responses.	N-Acetylneuraminic Acid	0-11	CD8a molecule	Homo sapiens	78-81
29703719-6	2018	Sialic acid blockade also synergized with adoptive transfer of tumor-specific CD8+ T cells in vivo and enhanced CpG immune adjuvant therapy by increasing dendritic cell activation and subsequent CD8+ T-cell responses.	N-Acetylneuraminic Acid	0-11	CD8a molecule	Homo sapiens	195-198
29516297-7	2018	Ca(II) is also sequestered by the carboxylate groups of sialic acid present on glycan chains of cbLf thus provoking the release of LPS, contributing to bactericidal activity.	N-Acetylneuraminic Acid	56-67	carbonic anhydrase 2	Bos taurus	0-6
29587225-4	2018	Here we investigate the changes to EPO dynamics following enzymatic trimming of terminal sialic acid by amide hydrogen deuterium exchange mass spectrometry (HDX-MS).	N-Acetylneuraminic Acid	89-100	erythropoietin	Homo sapiens	35-38
29720219-3	2018	Multiple therapeutic attempts are being made to supplement sialic acid depleted in GNE myopathy muscle cells.	N-Acetylneuraminic Acid	59-70	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	83-86
29892572-5	2018	Knocking out a key gene in sialic acid metabolism, Cmas, inhibits synthesis of the activated form of sialic acid, cytidine monophosphate-sialic acid and decreases the formation of lung metastases in vivo.	N-Acetylneuraminic Acid	27-38	cytidine monophospho-N-acetylneuraminic acid synthetase	Mus musculus	51-55
29892572-5	2018	Knocking out a key gene in sialic acid metabolism, Cmas, inhibits synthesis of the activated form of sialic acid, cytidine monophosphate-sialic acid and decreases the formation of lung metastases in vivo.	N-Acetylneuraminic Acid	101-112	cytidine monophospho-N-acetylneuraminic acid synthetase	Mus musculus	51-55
29892572-5	2018	Knocking out a key gene in sialic acid metabolism, Cmas, inhibits synthesis of the activated form of sialic acid, cytidine monophosphate-sialic acid and decreases the formation of lung metastases in vivo.	N-Acetylneuraminic Acid	101-112	cytidine monophospho-N-acetylneuraminic acid synthetase	Mus musculus	51-55
29623903-9	2018	Furthermore, comparison between GD1a and GYPA conditions shows that the cholesterol dependence of the hemifusion time is severely affected by the sialic-acid donor.	N-Acetylneuraminic Acid	146-157	glycophorin A (MNS blood group)	Homo sapiens	41-45
29743626-2	2018	SA synthesis is regulated by UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) that catalyzes rate limiting steps.	N-Acetylneuraminic Acid	0-2	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	67-70
29862060-3	2018	In Cuba, the Center for Molecular Immunology (CIM) is a cutting edge scientific center where the recombinant form (EPOrh) and recombinant human erythropoietin with low sialic acid (NeuroEPO) are produced.	N-Acetylneuraminic Acid	168-179	erythropoietin	Homo sapiens	144-158
29423831-6	2018	Using targeted mass spectrometry, we confirmed that free sialic acid was increased in the CSF of a third known POLG-mutated patient.	N-Acetylneuraminic Acid	57-68	DNA polymerase gamma, catalytic subunit	Homo sapiens	111-115
29266251-3	2018	In this study, micro-array data identified the upregulation of sialic acid-binding immunoglobulin-type lectin 1 (Siglec-1) in human RSV-infected infants.	N-Acetylneuraminic Acid	63-74	sialic acid binding Ig like lectin 1	Homo sapiens	113-121
29341588-8	2018	We report that 9- O-acetylation had a significant, and differential, impact on sialic acid hydrolysis by hNEU with general substrate tolerance following the trend of Neu5Ac &gt; Neu5Gc &gt;&gt; Neu5,9Ac2 for NEU2, NEU3, and NEU4.	N-Acetylneuraminic Acid	79-90	neuraminidase 1	Homo sapiens	105-109
29341588-8	2018	We report that 9- O-acetylation had a significant, and differential, impact on sialic acid hydrolysis by hNEU with general substrate tolerance following the trend of Neu5Ac &gt; Neu5Gc &gt;&gt; Neu5,9Ac2 for NEU2, NEU3, and NEU4.	N-Acetylneuraminic Acid	79-90	neuraminidase 2	Homo sapiens	208-212
29341588-8	2018	We report that 9- O-acetylation had a significant, and differential, impact on sialic acid hydrolysis by hNEU with general substrate tolerance following the trend of Neu5Ac &gt; Neu5Gc &gt;&gt; Neu5,9Ac2 for NEU2, NEU3, and NEU4.	N-Acetylneuraminic Acid	79-90	neuraminidase 3	Homo sapiens	214-218
29341588-8	2018	We report that 9- O-acetylation had a significant, and differential, impact on sialic acid hydrolysis by hNEU with general substrate tolerance following the trend of Neu5Ac &gt; Neu5Gc &gt;&gt; Neu5,9Ac2 for NEU2, NEU3, and NEU4.	N-Acetylneuraminic Acid	79-90	neuraminidase 4	Homo sapiens	224-228
29341588-11	2018	The impact of these minor structural changes to sialic acid on hNEU activity was unexpected, and these results provide evidence of the substantial influence of 9- O-Ac modifications on hNEU enzyme substrate specificity.	N-Acetylneuraminic Acid	48-59	neuraminidase 1	Homo sapiens	63-67
29483296-6	2018	In addition, we created a catalytically inactive version of the NanH enzyme (FRIP   YMAP) that retained its ability to bind sialic acid-containing ligands and revealed for the first time that binding activity of a CBM is enhanced by association with the catalytic domain.	N-Acetylneuraminic Acid	124-135	neuraminidase 1	Homo sapiens	64-68
29212895-11	2018	Mechanistically, Neu5Ac was able to trigger myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated coiled-coil containing protein kinase signaling pathway through binding to RhoA and Cdc42, but not Rac1.	N-Acetylneuraminic Acid	17-23	ras homolog family member A	Homo sapiens	198-202
29212895-11	2018	Mechanistically, Neu5Ac was able to trigger myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated coiled-coil containing protein kinase signaling pathway through binding to RhoA and Cdc42, but not Rac1.	N-Acetylneuraminic Acid	17-23	cell division cycle 42	Homo sapiens	207-212
29212895-11	2018	Mechanistically, Neu5Ac was able to trigger myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated coiled-coil containing protein kinase signaling pathway through binding to RhoA and Cdc42, but not Rac1.	N-Acetylneuraminic Acid	17-23	Rac family small GTPase 1	Homo sapiens	222-226
29212895-12	2018	Silencing neuraminidase-1, the enzyme that regulates Neu5Ac generation, ameliorated oxygen-glucose deprivation-induced injury in cardiomyocytes and ligation/isoprenaline-induced myocardial ischemia injury in rats.	N-Acetylneuraminic Acid	53-59	neuraminidase 1	Rattus norvegicus	10-25
29374074-4	2018	However, mice expressing a mutant form of CD22 unable to bind sialic acid ligands generated normal TI-2 Ab responses, despite significantly reduced MZ B cells.	N-Acetylneuraminic Acid	62-73	CD22 antigen	Mus musculus	42-46
29570654-5	2018	A protein stored in the micronemes, called Micronemal Protein 1 (MIC-1), contains a sialic acid binding domain that participates in the invasion process of host cells and is a vaccine candidate in other apicomplexan parasites.	N-Acetylneuraminic Acid	84-95	major histocompatibility class I related protein	Bos taurus	65-70
29328525-0	2018	Role of sialic acid-containing glycans of matrix metalloproteinase-9 (MMP-9) in the interaction between MMP-9 and staphylococcal superantigen-like protein 5.	N-Acetylneuraminic Acid	8-19	matrix metallopeptidase 9	Homo sapiens	42-68
29328525-0	2018	Role of sialic acid-containing glycans of matrix metalloproteinase-9 (MMP-9) in the interaction between MMP-9 and staphylococcal superantigen-like protein 5.	N-Acetylneuraminic Acid	8-19	matrix metallopeptidase 9	Homo sapiens	70-75
29328525-0	2018	Role of sialic acid-containing glycans of matrix metalloproteinase-9 (MMP-9) in the interaction between MMP-9 and staphylococcal superantigen-like protein 5.	N-Acetylneuraminic Acid	8-19	matrix metallopeptidase 9	Homo sapiens	104-109
29328525-3	2018	These interactions were suggested to depend on sialic acid-containing glycans of MMP-9, but the roles of sialic acids in the interaction between SSL5 and MMP-9 are still controversial.	N-Acetylneuraminic Acid	47-58	matrix metallopeptidase 9	Homo sapiens	81-86
29328525-7	2018	Furthermore, recombinant MMP-9 produced by sialic acid-deficient Lec2 mutant cells showed much lower affinity for SSL5 than that produced by wild-type CHO-K1 cells.	N-Acetylneuraminic Acid	43-54	matrix metalloproteinase-9	Cricetulus griseus	25-30
29328525-10	2018	These results strongly suggest the importance of the sialic acid-containing O-glycans of MMP-9 for the interaction of MMP-9 with GST-SSL5.	N-Acetylneuraminic Acid	53-64	matrix metallopeptidase 9	Homo sapiens	89-94
29328525-10	2018	These results strongly suggest the importance of the sialic acid-containing O-glycans of MMP-9 for the interaction of MMP-9 with GST-SSL5.	N-Acetylneuraminic Acid	53-64	matrix metallopeptidase 9	Homo sapiens	118-123
29282218-1	2018	Previous studies have shown that loss of terminal sialic acid causes enhanced von Willebrand factor (VWF) clearance through the Ashwell-Morrell receptor (AMR).	N-Acetylneuraminic Acid	50-61	Von Willebrand factor	Mus musculus	78-99
29489903-2	2018	Recently, we explored the use of a bicyclic (bicyclo[3.1.0]hexane) analogue of sialic acid that was designed to mimic the conformation adopted during enzymatic cleavage within the neuraminidase (NA; sialidase) active site.	N-Acetylneuraminic Acid	79-90	neuraminidase 1	Homo sapiens	180-193
29489903-2	2018	Recently, we explored the use of a bicyclic (bicyclo[3.1.0]hexane) analogue of sialic acid that was designed to mimic the conformation adopted during enzymatic cleavage within the neuraminidase (NA; sialidase) active site.	N-Acetylneuraminic Acid	79-90	neuraminidase 1	Homo sapiens	195-197
29491407-6	2018	Using this platform, high-affinity glycan ligands are discovered for Siglec-15-a sialic acid-binding lectin involved in osteoclast differentiation.	N-Acetylneuraminic Acid	81-92	sialic acid binding Ig like lectin 15	Homo sapiens	69-78
29282218-1	2018	Previous studies have shown that loss of terminal sialic acid causes enhanced von Willebrand factor (VWF) clearance through the Ashwell-Morrell receptor (AMR).	N-Acetylneuraminic Acid	50-61	Von Willebrand factor	Mus musculus	101-104
29282218-3	2018	alpha2-3-linked sialic acid accounts for &lt;20% of total sialic acid and is predominantly expressed on VWF O-glycans.	N-Acetylneuraminic Acid	16-27	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	0-8
29282218-3	2018	alpha2-3-linked sialic acid accounts for &lt;20% of total sialic acid and is predominantly expressed on VWF O-glycans.	N-Acetylneuraminic Acid	16-27	Von Willebrand factor	Mus musculus	104-107
29282218-3	2018	alpha2-3-linked sialic acid accounts for &lt;20% of total sialic acid and is predominantly expressed on VWF O-glycans.	N-Acetylneuraminic Acid	58-69	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	0-8
29271120-1	2018	Neuraminidase family enzymes that hydrolyze the terminal sialic acid linkage in biomolecules are involved in various immune responses.	N-Acetylneuraminic Acid	57-68	neuraminidase 1	Homo sapiens	0-13
29438293-3	2018	The objective of this study, using an in vitro model, was to determine how neuroEPO-which is a variant of EPO with a low sialic acid content-protects neurons from the toxic action of glutamate.	N-Acetylneuraminic Acid	121-132	erythropoietin	Rattus norvegicus	80-83
29440651-6	2018	Furthermore, distribution of the major actors of the sialic acid pathway in the different eukaryotic phyla indicated that these were already present in the LECA, which could also access to this essential monosaccharide either endogenously or via a sialin/sialidase uptake mechanism involving vesicles.	N-Acetylneuraminic Acid	53-64	solute carrier family 17 member 5	Homo sapiens	248-254
29426894-6	2018	Among the six N-glycosylation sites of serum soluble FcgammaRIIIb, Asn45 was shown to be exclusively occupied by high-mannose-type oligosaccharides, whereas the remaining sites were solely modified by the complex-type oligosaccharides with sialic acid and fucose residues.	N-Acetylneuraminic Acid	240-251	Fc gamma receptor IIIb	Homo sapiens	53-65
29385091-1	2018	Amino acid residues 283-297 from sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) form a cyclic peptide ligand targeting vascular adhesion protein-1 (VAP-1).	N-Acetylneuraminic Acid	33-44	amine oxidase, copper containing 3	Rattus norvegicus	132-159
29305133-1	2018	GNE myopathy is a rare distal myopathy, caused by mutations in the GNE gene, affecting sialic acid synthesis.	N-Acetylneuraminic Acid	87-98	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
29305133-1	2018	GNE myopathy is a rare distal myopathy, caused by mutations in the GNE gene, affecting sialic acid synthesis.	N-Acetylneuraminic Acid	87-98	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	67-70
29385091-1	2018	Amino acid residues 283-297 from sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) form a cyclic peptide ligand targeting vascular adhesion protein-1 (VAP-1).	N-Acetylneuraminic Acid	33-44	amine oxidase, copper containing 3	Rattus norvegicus	161-166
30023283-2	2018	Lysosomal neuraminidase catalyzes the removal of terminal sialic acid molecules from glycolipids, glycoproteins and oligosaccharides.	N-Acetylneuraminic Acid	58-69	neuraminidase 1	Homo sapiens	10-23
29344581-5	2018	We show that Lu/BCAM-mediated binding to laminin-alpha5 is restricted by interacting, in cis, with glycophorin-C-derived sialic acid residues.	N-Acetylneuraminic Acid	121-132	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	16-20
29344581-5	2018	We show that Lu/BCAM-mediated binding to laminin-alpha5 is restricted by interacting, in cis, with glycophorin-C-derived sialic acid residues.	N-Acetylneuraminic Acid	121-132	glycophorin C (Gerbich blood group)	Homo sapiens	99-112
29344581-6	2018	Following loss of sialic acid during erythrocyte aging, Lu/BCAM is released from glycophorin-C and allowed to interact with sialic acid residues on laminin-alpha5.	N-Acetylneuraminic Acid	18-29	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	59-63
29202472-8	2018	In HFD-fed mice, supplementation with the sialic acid precursor N-acetyl-D-mannosamine restored IgG sialylation and preserved insulin sensitivity without affecting weight gain.	N-Acetylneuraminic Acid	42-53	insulin	Homo sapiens	126-133
29344581-6	2018	Following loss of sialic acid during erythrocyte aging, Lu/BCAM is released from glycophorin-C and allowed to interact with sialic acid residues on laminin-alpha5.	N-Acetylneuraminic Acid	18-29	glycophorin C (Gerbich blood group)	Homo sapiens	81-94
29344581-6	2018	Following loss of sialic acid during erythrocyte aging, Lu/BCAM is released from glycophorin-C and allowed to interact with sialic acid residues on laminin-alpha5.	N-Acetylneuraminic Acid	124-135	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	59-63
29344581-6	2018	Following loss of sialic acid during erythrocyte aging, Lu/BCAM is released from glycophorin-C and allowed to interact with sialic acid residues on laminin-alpha5.	N-Acetylneuraminic Acid	124-135	glycophorin C (Gerbich blood group)	Homo sapiens	81-94
29344581-8	2018	In addition, we identified the sialic acid-binding site within the third immunoglobulin-like domain within Lu/BCAM that accounts for the interaction with glycophorin-C and laminin-alpha5.	N-Acetylneuraminic Acid	31-42	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	110-114
29344581-8	2018	In addition, we identified the sialic acid-binding site within the third immunoglobulin-like domain within Lu/BCAM that accounts for the interaction with glycophorin-C and laminin-alpha5.	N-Acetylneuraminic Acid	31-42	glycophorin C (Gerbich blood group)	Homo sapiens	154-167
29344581-9	2018	Last, we present evidence that neuraminidase-expressing pathogens, such as Streptococcus pneumoniae, can similarly induce Lu/BCAM-mediated binding to laminin-alpha5, by cleaving terminal sialic acid residues from the erythrocyte membrane.	N-Acetylneuraminic Acid	187-198	neuraminidase 1	Homo sapiens	31-44
29344581-9	2018	Last, we present evidence that neuraminidase-expressing pathogens, such as Streptococcus pneumoniae, can similarly induce Lu/BCAM-mediated binding to laminin-alpha5, by cleaving terminal sialic acid residues from the erythrocyte membrane.	N-Acetylneuraminic Acid	187-198	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	125-129
29206915-1	2018	The enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH) is responsible for the synthesis of N-glycolylneuraminic acid (Neu5Gc), a sialic acid present on the cell surface proteins of most deuterostomes.	N-Acetylneuraminic Acid	132-143	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	52-56
29146181-0	2018	Proximity labeling of cis-ligands of CD22/Siglec-2 reveals stepwise alpha2,6 sialic acid-dependent and -independent interactions.	N-Acetylneuraminic Acid	77-88	CD22 antigen	Mus musculus	37-41
29146181-0	2018	Proximity labeling of cis-ligands of CD22/Siglec-2 reveals stepwise alpha2,6 sialic acid-dependent and -independent interactions.	N-Acetylneuraminic Acid	77-88	CD22 antigen	Mus musculus	42-50
29102779-2	2018	Sialic acid (SA) is an indispensable nutrient for early brain development, and its polymer polySia (PSA) can modify neural cell adhesion molecules (NCAM), thereby indirectly mediating neuronal outgrowth, synaptic connectivity and memory formation.	N-Acetylneuraminic Acid	0-11	neural cell adhesion molecule 1	Homo sapiens	148-152
29102779-2	2018	Sialic acid (SA) is an indispensable nutrient for early brain development, and its polymer polySia (PSA) can modify neural cell adhesion molecules (NCAM), thereby indirectly mediating neuronal outgrowth, synaptic connectivity and memory formation.	N-Acetylneuraminic Acid	13-15	neural cell adhesion molecule 1	Homo sapiens	148-152
28236367-1	2018	BACKGROUND: Transferrin, a major glycoprotein has different isoforms depending on the number of sialic acid residues present on its oligosaccharide chain.	N-Acetylneuraminic Acid	96-107	transferrin	Homo sapiens	12-23
27643667-8	2018	RESULTS: Compared with intact MPO, chlorination activity of deglycosylated MPO declined, in which removing of beta-galactopyranoside (0.35 +- 0.02 vs. 0.50 +- 0.04, P &lt; 0.001) and alpha-linked sialic acid (0.35 +- 0.02 vs. 0.50 +- 0.04, P &lt; 0.001) presented the most significance.	N-Acetylneuraminic Acid	196-207	myeloperoxidase	Homo sapiens	75-78
29134771-0	2018	Detection of beta-Amyloid by Sialic Acid Coated Bovine Serum Albumin Magnetic Nanoparticles in a Mouse Model of Alzheimer"s Disease.	N-Acetylneuraminic Acid	29-40	albumin	Mus musculus	55-68
29134771-4	2018	In this work, bovine serum albumin (BSA) coated NPs are decorated with sialic acid (NP-BSAx -Sia) to overcome the challenges in Abeta imaging in vivo.	N-Acetylneuraminic Acid	71-82	albumin	Mus musculus	21-34
29134771-4	2018	In this work, bovine serum albumin (BSA) coated NPs are decorated with sialic acid (NP-BSAx -Sia) to overcome the challenges in Abeta imaging in vivo.	N-Acetylneuraminic Acid	71-82	amyloid beta (A4) precursor protein	Mus musculus	128-133
29134771-6	2018	The NP-BSAx -Sia binds with Abeta in a sialic acid dependent manner with high selectivities toward Abeta deposited on brains and cross the BBB in an in vitro model.	N-Acetylneuraminic Acid	39-50	amyloid beta (A4) precursor protein	Mus musculus	28-33
29134771-6	2018	The NP-BSAx -Sia binds with Abeta in a sialic acid dependent manner with high selectivities toward Abeta deposited on brains and cross the BBB in an in vitro model.	N-Acetylneuraminic Acid	39-50	amyloid beta (A4) precursor protein	Mus musculus	99-104
29046357-2	2017	PILRalpha belongs to the Siglec (sialic acid (SA)-binding immunoglobulin-like lectin)-like family, members of which bind SA.	N-Acetylneuraminic Acid	33-44	paired immunoglobin like type 2 receptor alpha	Homo sapiens	0-9
29463960-1	2017	Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP-1).	N-Acetylneuraminic Acid	0-11	sialic acid binding Ig like lectin 9	Homo sapiens	50-58
29463960-1	2017	Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP-1).	N-Acetylneuraminic Acid	0-11	amine oxidase, copper containing 3	Rattus norvegicus	98-125
29463960-1	2017	Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP-1).	N-Acetylneuraminic Acid	0-11	amine oxidase, copper containing 3	Rattus norvegicus	127-132
29046357-2	2017	PILRalpha belongs to the Siglec (sialic acid (SA)-binding immunoglobulin-like lectin)-like family, members of which bind SA.	N-Acetylneuraminic Acid	46-48	paired immunoglobin like type 2 receptor alpha	Homo sapiens	0-9
29046357-2	2017	PILRalpha belongs to the Siglec (sialic acid (SA)-binding immunoglobulin-like lectin)-like family, members of which bind SA.	N-Acetylneuraminic Acid	121-123	paired immunoglobin like type 2 receptor alpha	Homo sapiens	0-9
29026192-3	2017	Here, we show that by reducing the amount of intracellular CMP-Neu5Ac consumed for glycosphingolipid (GSL) biosynthesis, we can increase the sialylation of recombinant human erythropoietin (rhEPO) produced in CHO cells.	N-Acetylneuraminic Acid	63-69	erythropoietin	Homo sapiens	174-188
28829050-5	2017	We discovered that THP engages the inhibitory neutrophil receptor sialic acid-binding Ig-like lectin-9 (Siglec-9), and mouse functional ortholog Siglec-E, in a manner dependent on sialic acid on its N-glycan moieties.	N-Acetylneuraminic Acid	66-77	uromodulin	Mus musculus	19-22
28829050-5	2017	We discovered that THP engages the inhibitory neutrophil receptor sialic acid-binding Ig-like lectin-9 (Siglec-9), and mouse functional ortholog Siglec-E, in a manner dependent on sialic acid on its N-glycan moieties.	N-Acetylneuraminic Acid	66-77	sialic acid binding Ig-like lectin E	Mus musculus	104-112
29039925-2	2017	The plasma membrane-associated sialidase NEU3 is involved in the fine-tuning of sialic acid-containing glycans directly on the cell surface and plays relevant roles in important biological phenomena such as cell differentiation, molecular recognition, and cancer transformation.	N-Acetylneuraminic Acid	80-91	neuraminidase 3	Homo sapiens	41-45
28895049-1	2017	GNE myopathy is a rare neuromuscular genetic disorder characterized by early adult onset and muscle weakness due to mutation in sialic acid biosynthetic enzyme, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE).	N-Acetylneuraminic Acid	128-139	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
28895049-1	2017	GNE myopathy is a rare neuromuscular genetic disorder characterized by early adult onset and muscle weakness due to mutation in sialic acid biosynthetic enzyme, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE).	N-Acetylneuraminic Acid	128-139	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	161-223
28895049-1	2017	GNE myopathy is a rare neuromuscular genetic disorder characterized by early adult onset and muscle weakness due to mutation in sialic acid biosynthetic enzyme, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE).	N-Acetylneuraminic Acid	128-139	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	225-228
29169316-7	2017	The phylogenetic tree demonstrated that gene conversions between SIGLEC11 and SIGLEC16 occurred in the region including the exon encoding the sialic acid binding domain in every primate examined.	N-Acetylneuraminic Acid	142-153	sialic acid binding Ig like lectin 11	Homo sapiens	65-73
29169316-7	2017	The phylogenetic tree demonstrated that gene conversions between SIGLEC11 and SIGLEC16 occurred in the region including the exon encoding the sialic acid binding domain in every primate examined.	N-Acetylneuraminic Acid	142-153	sialic acid binding Ig like lectin 16	Homo sapiens	78-86
29058413-8	2017	The fucosidase had significantly lower action where sialic acid neighbors the fucose, and the neuraminidase showed statistically lower action where alpha1-2 fucose neighbors the sialic acid or is on the opposing branch.	N-Acetylneuraminic Acid	178-189	neuraminidase 1	Homo sapiens	94-107
29058413-8	2017	The fucosidase had significantly lower action where sialic acid neighbors the fucose, and the neuraminidase showed statistically lower action where alpha1-2 fucose neighbors the sialic acid or is on the opposing branch.	N-Acetylneuraminic Acid	178-189	adrenoceptor alpha 1D	Homo sapiens	148-156
28972089-1	2017	CD22, a sialic acid-binding Ig-type lectin (Siglec) family member, is an inhibitory coreceptor of the BCR with established roles in health and disease.	N-Acetylneuraminic Acid	8-19	CD22 antigen	Mus musculus	0-4
28922741-1	2017	Sialic acid acetylesterase (SIAE) removes acetyl moieties from the carbon 9 and 4 hydroxyl groups of sialic acid and recently a debate has been opened on its association to autoimmunity.	N-Acetylneuraminic Acid	101-112	sialic acid acetylesterase	Danio rerio	0-26
28651174-0	2017	Label-free chronopotentiometric glycoprofiling of prostate specific antigen using sialic acid recognizing lectins.	N-Acetylneuraminic Acid	82-93	kallikrein related peptidase 3	Homo sapiens	50-75
28970495-3	2017	Here we report the crystal structure of human CD22 at 2.1 A resolution, which reveals that specificity for alpha2-6 sialic acid ligands is dictated by a pre-formed beta-hairpin as a unique mode of recognition across sialic acid-binding immunoglobulin-type lectins.	N-Acetylneuraminic Acid	116-127	CD22 molecule	Homo sapiens	46-50
28970495-3	2017	Here we report the crystal structure of human CD22 at 2.1 A resolution, which reveals that specificity for alpha2-6 sialic acid ligands is dictated by a pre-formed beta-hairpin as a unique mode of recognition across sialic acid-binding immunoglobulin-type lectins.	N-Acetylneuraminic Acid	116-127	immunoglobulin binding protein 1	Homo sapiens	107-115
28970495-3	2017	Here we report the crystal structure of human CD22 at 2.1 A resolution, which reveals that specificity for alpha2-6 sialic acid ligands is dictated by a pre-formed beta-hairpin as a unique mode of recognition across sialic acid-binding immunoglobulin-type lectins.	N-Acetylneuraminic Acid	216-227	CD22 molecule	Homo sapiens	46-50
28970495-3	2017	Here we report the crystal structure of human CD22 at 2.1 A resolution, which reveals that specificity for alpha2-6 sialic acid ligands is dictated by a pre-formed beta-hairpin as a unique mode of recognition across sialic acid-binding immunoglobulin-type lectins.	N-Acetylneuraminic Acid	216-227	immunoglobulin binding protein 1	Homo sapiens	107-115
28571946-1	2017	Severe auditory impairment observed in GM3 synthase-deficient mice and humans indicates that glycosphingolipids, especially sialic-acid containing gangliosides, are indispensable for hearing.	N-Acetylneuraminic Acid	124-135	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	39-51
28829594-1	2017	CD22 is a sialic acid-binding immunoglobulin-like lectin (Siglec) that is highly expressed on B-cells and B cell lymphomas, and is a validated target for antibody and nanoparticle based therapeutics.	N-Acetylneuraminic Acid	10-21	CD22 molecule	Homo sapiens	0-4
28893995-1	2017	Biosynthesis of the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) was lost during human evolution due to inactivation of the CMAH gene, possibly expediting divergence of the Homo lineage, due to a partial fertility barrier.	N-Acetylneuraminic Acid	37-48	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	143-147
28502901-3	2017	HN plays central roles in PorPV infection; i.e., it recognizes sialic acid-containing cell receptors that mediate virus attachment and penetration; in addition, its neuraminidase (sialic acid releasing) activity has been proposed as a virulence factor.	N-Acetylneuraminic Acid	180-191	neuraminidase 1	Homo sapiens	165-178
28858492-4	2017	It is shown that recombinant ST6GAL1 can readily transfer the modified sialic acid to N-glycans of glycoprotein acceptors of living cells resulting in long-lived display.	N-Acetylneuraminic Acid	71-82	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	29-36
28902191-1	2017	The selective hydrolysis of the glycosidic bond between the terminal sialic acid and the penultimate sugar has been achieved in the alpha-2-HS-glycoprotein (Fetuin-A) in the presence of H3PW12O40, a Keggin type polyoxometalate.	N-Acetylneuraminic Acid	69-80	alpha 2-HS glycoprotein	Homo sapiens	157-165
28747436-2	2017	CD33 generates two splice variants: a full-length CD33M transcript produced primarily by the "LOAD-risk" allele and a shorter CD33m isoform lacking the sialic acid-binding domain produced primarily from the "LOAD-protective" allele.	N-Acetylneuraminic Acid	152-163	CD33 molecule	Homo sapiens	0-4
28880920-4	2017	Site-directed mutagenesis of the conserved sialic acid-binding motif of SElX abolished neutrophil binding and phagocytic killing, and revealed multiple glycosylated neutrophil receptors for SElX binding.	N-Acetylneuraminic Acid	43-54	methionine sulfoxide reductase B1	Homo sapiens	72-76
28724773-2	2017	Here we show that the human NK cell-activating receptor NKp46 and the orthologous mouse protein NCR1 recognize the reovirus sigma1 protein in a sialic-acid-dependent manner.	N-Acetylneuraminic Acid	144-155	natural cytotoxicity triggering receptor 1	Homo sapiens	28-55
28724773-2	2017	Here we show that the human NK cell-activating receptor NKp46 and the orthologous mouse protein NCR1 recognize the reovirus sigma1 protein in a sialic-acid-dependent manner.	N-Acetylneuraminic Acid	144-155	natural cytotoxicity triggering receptor 1	Homo sapiens	56-61
28724773-2	2017	Here we show that the human NK cell-activating receptor NKp46 and the orthologous mouse protein NCR1 recognize the reovirus sigma1 protein in a sialic-acid-dependent manner.	N-Acetylneuraminic Acid	144-155	natural cytotoxicity triggering receptor 1	Mus musculus	96-100
28505249-2	2017	Genetic defects of the GNE gene which encodes a critical bifunctional enzyme for sialic acid biosynthesis, lead to GNE myopathy, a disease manifesting with progressive muscle atrophy and weakness.	N-Acetylneuraminic Acid	81-92	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	23-26
28662915-1	2017	BACKGROUND: Likely pathogenic variants in SLC17A5 results in allelic disorders of free sialic acid metabolism including (1) infantile free sialic acid storage disease with severe global developmental delay, coarse facial features, hepatosplenomegaly, and cardiomegaly; (2) intermediate severe Salla disease with moderate to severe global developmental delay, hypotonia, and hypomyelination with or without coarse facial features, and (3) Salla disease with normal appearance, mild cognitive dysfunction, and spasticity.	N-Acetylneuraminic Acid	87-98	solute carrier family 17 member 5	Homo sapiens	42-49
28662915-1	2017	BACKGROUND: Likely pathogenic variants in SLC17A5 results in allelic disorders of free sialic acid metabolism including (1) infantile free sialic acid storage disease with severe global developmental delay, coarse facial features, hepatosplenomegaly, and cardiomegaly; (2) intermediate severe Salla disease with moderate to severe global developmental delay, hypotonia, and hypomyelination with or without coarse facial features, and (3) Salla disease with normal appearance, mild cognitive dysfunction, and spasticity.	N-Acetylneuraminic Acid	139-150	solute carrier family 17 member 5	Homo sapiens	42-49
28536081-1	2017	Beta-1,4-N-acetyl galactosaminyltransferase 1, B4GALNT1, is a GM2/GD2 synthase, involved in the expression of glycosphingolipids (GSLs) containing sialic acid.	N-Acetylneuraminic Acid	147-158	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	0-45
28821225-4	2017	Our previous study showed that the P. gingivalis sialidase can help cells obtain sialic acid from the environment, which is used to modify macromolecules on the surface of P. gingivalis cells.	N-Acetylneuraminic Acid	81-92	PG_RS01565	Porphyromonas gingivalis W83	49-58
28641925-1	2017	GNE myopathy is a rare, autosomal recessive, inborn error of sialic acid metabolism, caused by mutations in GNE, the gene encoding UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase.	N-Acetylneuraminic Acid	61-72	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
28641925-1	2017	GNE myopathy is a rare, autosomal recessive, inborn error of sialic acid metabolism, caused by mutations in GNE, the gene encoding UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase.	N-Acetylneuraminic Acid	61-72	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	108-111
28641925-5	2017	N-acetyl-D-mannosamine (ManNAc), an uncharged monosaccharide and the first committed precursor in the sialic acid biosynthetic pathway, is a therapeutic candidate that prevents muscle weakness in the mouse model of GNE myopathy.	N-Acetylneuraminic Acid	102-113	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	215-218
28641925-11	2017	Given that Neu5Ac is known to have a short half-life, the prolonged elevation of Neu5Ac after a single dose of ManNAc suggests that intracellular biosynthesis of sialic acid was restored in subjects with GNE myopathy, including those homozygous for mutations in the kinase domain.	N-Acetylneuraminic Acid	11-17	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	204-207
28641925-11	2017	Given that Neu5Ac is known to have a short half-life, the prolonged elevation of Neu5Ac after a single dose of ManNAc suggests that intracellular biosynthesis of sialic acid was restored in subjects with GNE myopathy, including those homozygous for mutations in the kinase domain.	N-Acetylneuraminic Acid	81-87	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	204-207
28641925-11	2017	Given that Neu5Ac is known to have a short half-life, the prolonged elevation of Neu5Ac after a single dose of ManNAc suggests that intracellular biosynthesis of sialic acid was restored in subjects with GNE myopathy, including those homozygous for mutations in the kinase domain.	N-Acetylneuraminic Acid	162-173	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	204-207
28536081-1	2017	Beta-1,4-N-acetyl galactosaminyltransferase 1, B4GALNT1, is a GM2/GD2 synthase, involved in the expression of glycosphingolipids (GSLs) containing sialic acid.	N-Acetylneuraminic Acid	147-158	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	47-55
28536081-1	2017	Beta-1,4-N-acetyl galactosaminyltransferase 1, B4GALNT1, is a GM2/GD2 synthase, involved in the expression of glycosphingolipids (GSLs) containing sialic acid.	N-Acetylneuraminic Acid	147-158	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	62-78
28607101-5	2017	Addition of purified MsgA and NanA to the FBS resulted in a release of 2.8 mM galactose and 4.3 mM N-acetylneuraminic acid; these sugar concentrations were sufficient to upregulate the expression of ILY, MsgA, and NanA.	N-Acetylneuraminic Acid	99-122	neuraminidase 1	Homo sapiens	30-34
28505249-2	2017	Genetic defects of the GNE gene which encodes a critical bifunctional enzyme for sialic acid biosynthesis, lead to GNE myopathy, a disease manifesting with progressive muscle atrophy and weakness.	N-Acetylneuraminic Acid	81-92	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	115-118
28512676-5	2017	Additionally, the perfusion culture produced similar fucose, more galactose and a higher proportion of sialic acid on the anti-CD52 mAb compared to the fed-batch culture.	N-Acetylneuraminic Acid	103-114	CD52 molecule	Homo sapiens	127-131
28295160-2	2017	In this study, the effect of applying a novel chemical analog of the sialic acid precursor N-acetylmannosamine (ManNAc) on the sialic acid content of cellular proteins and a model recombinant glycoprotein, erythropoietin (EPO), was investigated in CHO-K1 cells.	N-Acetylneuraminic Acid	69-80	erythropoietin	Cricetulus griseus	206-220
28554385-7	2017	Sialic acid content of Alb-EPO was highest in co-transfected cells with excess Mgat4 gene, and these cells showed a higher tri- and tetra-antennary structure than control cells.	N-Acetylneuraminic Acid	0-11	albumin	Cricetulus griseus	23-26
28295160-3	2017	By introducing the 1,3,4-O-Bu3 ManNAc analog at 200-300 microM into cell culture media, the intracellular sialic acid content of EPO-expressing cells increased ~8-fold over untreated controls while the level of cellular sialylated glycoconjugates increased significantly as well.	N-Acetylneuraminic Acid	106-117	erythropoietin	Cricetulus griseus	129-132
28295160-4	2017	For example, addition of 200-300 microM 1,3,4-O-Bu3 ManNAc resulted in &gt;40% increase in final sialic acid content of recombinant EPO, while natural ManNAc at ~100 times higher concentration of 20 mM produced a less profound change in EPO sialylation.	N-Acetylneuraminic Acid	97-108	erythropoietin	Cricetulus griseus	132-135
28295160-5	2017	Collectively, these results indicate that butyrate-derivatization of ManNAc improves the capacity of cells to incorporate exogenous ManNAc into the sialic acid biosynthetic pathway and thereby increase sialylation of recombinant EPO and other glycoproteins.	N-Acetylneuraminic Acid	148-159	erythropoietin	Cricetulus griseus	229-232
28554385-7	2017	Sialic acid content of Alb-EPO was highest in co-transfected cells with excess Mgat4 gene, and these cells showed a higher tri- and tetra-antennary structure than control cells.	N-Acetylneuraminic Acid	0-11	erythropoietin	Cricetulus griseus	27-30
28742001-2	2017	Porcine sialoadhesin [pSn, also known as sialic acid-binding immunoglobulin-type lectin (Siglec-1)] and porcine CD163 (pCD163) have been identified as the most important host entry mediators that can fully coordinate PRRSV infection into macrophages.	N-Acetylneuraminic Acid	41-52	sialic acid binding Ig like lectin 1	Homo sapiens	8-20
28442549-3	2017	We demonstrate that 2 mammalian enzymes, neuraminidases 3 and 4, play important roles in catabolic processing of brain gangliosides by cleaving terminal sialic acid residues in their glycan chains.	N-Acetylneuraminic Acid	153-164	neuraminidase 3	Homo sapiens	41-63
28243847-9	2017	Findings regarding the intensity of sialic acid expression were aligned with PSA-NCAM expression.	N-Acetylneuraminic Acid	36-47	neural cell adhesion molecule 1	Rattus norvegicus	81-85
28542923-0	2017	The polysialic acid mimetics idarubicin and irinotecan stimulate neuronal survival and neurite outgrowth and signal via protein kinase C. Polysialic acid (PSA) is a large, negatively charged, linear homopolymer of alpha2-8-linked sialic acid residues.	N-Acetylneuraminic Acid	8-19	immunoglobulin binding protein 1	Homo sapiens	214-222
28649697-5	2017	Both normal and cancerous prostate tissues were sliced and cultured in the presence of the azide-functionalized sialic acid biosynthetic precursor Ac4 ManNAz.	N-Acetylneuraminic Acid	112-123	adenylate cyclase 4	Homo sapiens	147-150
28749326-1	2017	Neuraminidase A (NanA) is an important virulence factor that is anchored to the pneumococcal cell wall and cleaves sialic acid on host substrates.	N-Acetylneuraminic Acid	115-126	neuraminidase 1	Homo sapiens	0-13
28423240-1	2017	About 2-3 million years ago, Alu-mediated deletion of a critical exon in the CMAH gene became fixed in the hominin lineage ancestral to humans, possibly through a stepwise process of selection by pathogen targeting of the CMAH product (the sialic acid Neu5Gc), followed by reproductive isolation through female anti-Neu5Gc antibodies.	N-Acetylneuraminic Acid	240-251	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	77-81
28740108-4	2017	This may be attributed to a weak neuraminidase (NA) cleavage of carbon-6-linked sialic acid (Sia) rather than carbon-3-linked Sia.	N-Acetylneuraminic Acid	80-91	neuraminidase 1	Homo sapiens	33-46
28740108-4	2017	This may be attributed to a weak neuraminidase (NA) cleavage of carbon-6-linked sialic acid (Sia) rather than carbon-3-linked Sia.	N-Acetylneuraminic Acid	93-96	neuraminidase 1	Homo sapiens	33-46
28724897-3	2017	The biosynthesis of bacterial polySia is catalysed by a single polysialyltransferase (PST) transferring sialic acid from a nucleotide-activated donor to a lipid-linked acceptor oligosaccharide.	N-Acetylneuraminic Acid	104-115	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	63-84
28724897-3	2017	The biosynthesis of bacterial polySia is catalysed by a single polysialyltransferase (PST) transferring sialic acid from a nucleotide-activated donor to a lipid-linked acceptor oligosaccharide.	N-Acetylneuraminic Acid	104-115	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	86-89
28714909-6	2017	The neuraminidase, or the receptor-destroying protein, cleaves the sialic acid from cellular membrane constituents and viral glycoproteins allowing for egress of nascent virions.	N-Acetylneuraminic Acid	67-78	neuraminidase 1	Homo sapiens	4-17
28288142-0	2017	Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through sialic acid to promote ovarian cancer tumor growth and progression.	N-Acetylneuraminic Acid	88-99	serine hydroxymethyltransferase 1	Homo sapiens	0-34
28288142-7	2017	Unbiased large-scale metabolomic analysis and transcriptome-wide mRNA expression profiling identified reduced levels of several metabolites of the amino sugar and nucleotide sugar metabolic pathways, including sialic acid N-acetylneuraminic acid (Neu5Ac), and downregulation of pro-oncogenic cytokines interleukin-6 and 8 (IL-6 and IL-8) as unexpected outcomes of SHMT1 loss.	N-Acetylneuraminic Acid	210-221	interleukin 6	Homo sapiens	323-327
28288142-7	2017	Unbiased large-scale metabolomic analysis and transcriptome-wide mRNA expression profiling identified reduced levels of several metabolites of the amino sugar and nucleotide sugar metabolic pathways, including sialic acid N-acetylneuraminic acid (Neu5Ac), and downregulation of pro-oncogenic cytokines interleukin-6 and 8 (IL-6 and IL-8) as unexpected outcomes of SHMT1 loss.	N-Acetylneuraminic Acid	210-221	C-X-C motif chemokine ligand 8	Homo sapiens	332-336
28288142-7	2017	Unbiased large-scale metabolomic analysis and transcriptome-wide mRNA expression profiling identified reduced levels of several metabolites of the amino sugar and nucleotide sugar metabolic pathways, including sialic acid N-acetylneuraminic acid (Neu5Ac), and downregulation of pro-oncogenic cytokines interleukin-6 and 8 (IL-6 and IL-8) as unexpected outcomes of SHMT1 loss.	N-Acetylneuraminic Acid	210-221	serine hydroxymethyltransferase 1	Homo sapiens	364-369
28288142-9	2017	Supplementation of culture medium with Neu5Ac stimulated expression of IL-6 and IL-8 and rescued the tumor growth and migratory phenotypes of ovarian cancer cells expressing SHMT1 shRNAs.	N-Acetylneuraminic Acid	39-45	interleukin 6	Homo sapiens	71-75
28288142-9	2017	Supplementation of culture medium with Neu5Ac stimulated expression of IL-6 and IL-8 and rescued the tumor growth and migratory phenotypes of ovarian cancer cells expressing SHMT1 shRNAs.	N-Acetylneuraminic Acid	39-45	C-X-C motif chemokine ligand 8	Homo sapiens	80-84
28288142-9	2017	Supplementation of culture medium with Neu5Ac stimulated expression of IL-6 and IL-8 and rescued the tumor growth and migratory phenotypes of ovarian cancer cells expressing SHMT1 shRNAs.	N-Acetylneuraminic Acid	39-45	serine hydroxymethyltransferase 1	Homo sapiens	174-179
28288142-11	2017	Collectively, these results demonstrate that SHMT1 controls the expression of pro-oncogenic inflammatory cytokines by regulating sialic acid Neu5Ac to promote ovarian cancer tumor growth and migration.	N-Acetylneuraminic Acid	129-140	serine hydroxymethyltransferase 1	Homo sapiens	45-50
28288142-11	2017	Collectively, these results demonstrate that SHMT1 controls the expression of pro-oncogenic inflammatory cytokines by regulating sialic acid Neu5Ac to promote ovarian cancer tumor growth and migration.	N-Acetylneuraminic Acid	141-147	serine hydroxymethyltransferase 1	Homo sapiens	45-50
27966821-1	2017	Sialuria is a rare autosomal dominant disorder of mammalian metabolism, caused by defective feedback inhibition of the UDP-N-acetylglucosamine-2-epimerase N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.	N-Acetylneuraminic Acid	207-218	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	183-186
27966821-10	2017	Our results suggest that the intracellular sialic acid concentration regulates polysialylation on NCAM in vivo; this could play a role in the manifestation of the developmental delays in sialuria patients.	N-Acetylneuraminic Acid	43-54	neural cell adhesion molecule 1	Homo sapiens	98-102
28745640-4	2017	The analysis method to determine the phenotype of this mouse model is herein described in detail, and is based on the detection of both N-acetylneuraminic acid and N-glycolylenuraminic acid in the liver and milk of wild-type and Cmah knock-out mice.	N-Acetylneuraminic Acid	136-159	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Mus musculus	229-233
28395125-0	2017	Probing the CMP-Sialic Acid Donor Specificity of Two Human beta-d-Galactoside Sialyltransferases (ST3Gal I and ST6Gal I) Selectively Acting on O- and N-Glycosylproteins.	N-Acetylneuraminic Acid	16-27	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	98-106
28395125-0	2017	Probing the CMP-Sialic Acid Donor Specificity of Two Human beta-d-Galactoside Sialyltransferases (ST3Gal I and ST6Gal I) Selectively Acting on O- and N-Glycosylproteins.	N-Acetylneuraminic Acid	16-27	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	111-119
28395125-4	2017	In this study, we devised several approaches to investigate the donor specificity of the human beta-d-galactoside sialyltransferases ST6Gal I and ST3Gal I by using two CMP-sialic acids: CMP-Neu5Ac, and CMP-Neu5N-(4pentynoyl)neuraminic acid (CMP-SiaNAl), an unnatural CMP-sialic acid donor with an extended and functionalized N-acyl moiety.	N-Acetylneuraminic Acid	172-183	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	133-141
28395125-4	2017	In this study, we devised several approaches to investigate the donor specificity of the human beta-d-galactoside sialyltransferases ST6Gal I and ST3Gal I by using two CMP-sialic acids: CMP-Neu5Ac, and CMP-Neu5N-(4pentynoyl)neuraminic acid (CMP-SiaNAl), an unnatural CMP-sialic acid donor with an extended and functionalized N-acyl moiety.	N-Acetylneuraminic Acid	172-183	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	146-154
28423240-1	2017	About 2-3 million years ago, Alu-mediated deletion of a critical exon in the CMAH gene became fixed in the hominin lineage ancestral to humans, possibly through a stepwise process of selection by pathogen targeting of the CMAH product (the sialic acid Neu5Gc), followed by reproductive isolation through female anti-Neu5Gc antibodies.	N-Acetylneuraminic Acid	240-251	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	222-226
28895363-7	2017	The alpha-Gal was absent in mAb produced by CHO cell expression system containing sialic acid predominantly N-acetyl neuraminic acid (NANA) which is the desired, normal human-type sialylation.	N-Acetylneuraminic Acid	82-93	glycoprotein galactosyltransferase alpha 1, 3	Mus musculus	4-13
28460336-3	2017	We herein report on the application of phenylboronic acid-installed PEGylated gold nanoparticles coupled with Toluidine blue O (T/BA-GNPs) as SERS probes to target surface sialic acid (N-acetylneuraminic acid, Neu5Ac).	N-Acetylneuraminic Acid	172-183	seryl-tRNA synthetase 1	Homo sapiens	142-146
28460336-3	2017	We herein report on the application of phenylboronic acid-installed PEGylated gold nanoparticles coupled with Toluidine blue O (T/BA-GNPs) as SERS probes to target surface sialic acid (N-acetylneuraminic acid, Neu5Ac).	N-Acetylneuraminic Acid	185-208	seryl-tRNA synthetase 1	Homo sapiens	142-146
28460336-3	2017	We herein report on the application of phenylboronic acid-installed PEGylated gold nanoparticles coupled with Toluidine blue O (T/BA-GNPs) as SERS probes to target surface sialic acid (N-acetylneuraminic acid, Neu5Ac).	N-Acetylneuraminic Acid	210-216	seryl-tRNA synthetase 1	Homo sapiens	142-146
28460336-5	2017	The detected SERS signals from various cancer cell lines correlated with their reported metastatic potential, implying that our T/BA-GNP based SERS system was capable of distinguishing the metastaticity of cells based on the surface Neu5Ac density.	N-Acetylneuraminic Acid	233-239	seryl-tRNA synthetase 1	Homo sapiens	13-17
28460336-5	2017	The detected SERS signals from various cancer cell lines correlated with their reported metastatic potential, implying that our T/BA-GNP based SERS system was capable of distinguishing the metastaticity of cells based on the surface Neu5Ac density.	N-Acetylneuraminic Acid	233-239	seryl-tRNA synthetase 1	Homo sapiens	143-147
28895363-7	2017	The alpha-Gal was absent in mAb produced by CHO cell expression system containing sialic acid predominantly N-acetyl neuraminic acid (NANA) which is the desired, normal human-type sialylation.	N-Acetylneuraminic Acid	108-132	glycoprotein galactosyltransferase alpha 1, 3	Mus musculus	4-13
28640212-2	2017	In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activity was observed when sialic acid was conjugated with pentacyclic triterpene via C-4 than C-2.	N-Acetylneuraminic Acid	35-46	complement C2	Homo sapiens	48-51
28640212-0	2017	Synthesis and In Vitro Anti-Influenza Virus Evaluation of Novel Sialic Acid (C-5 and C-9)-Pentacyclic Triterpene Derivatives.	N-Acetylneuraminic Acid	64-75	complement C5	Homo sapiens	77-88
28640212-2	2017	In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activity was observed when sialic acid was conjugated with pentacyclic triterpene via C-4 than C-2.	N-Acetylneuraminic Acid	183-194	complement C2	Homo sapiens	48-59
28640212-2	2017	In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activity was observed when sialic acid was conjugated with pentacyclic triterpene via C-4 than C-2.	N-Acetylneuraminic Acid	35-46	complement C2	Homo sapiens	48-59
28640212-2	2017	In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activity was observed when sialic acid was conjugated with pentacyclic triterpene via C-4 than C-2.	N-Acetylneuraminic Acid	183-194	complement C4A (Rodgers blood group)	Homo sapiens	56-59
28640212-2	2017	In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activity was observed when sialic acid was conjugated with pentacyclic triterpene via C-4 than C-2.	N-Acetylneuraminic Acid	35-46	complement C4A (Rodgers blood group)	Homo sapiens	56-59
28640212-2	2017	In our previous study, a series of sialic acid (C-2 and C-4)-pentacyclic triterpene conjugates have been synthesized, and a five-fold more potent antiviral activity was observed when sialic acid was conjugated with pentacyclic triterpene via C-4 than C-2.	N-Acetylneuraminic Acid	183-194	complement C2	Homo sapiens	48-51
28640212-8	2017	The data suggested that both the C-5 acetylamide and C-9 hydroxy of sialic acid were important for its binding with hemagglutinin during viral entry into host cells, while C-4 and C-2 hydroxy were not critical for the binding process and could be replaced with hydrophobic moieties.	N-Acetylneuraminic Acid	68-79	complement C5	Homo sapiens	33-36
28640212-8	2017	The data suggested that both the C-5 acetylamide and C-9 hydroxy of sialic acid were important for its binding with hemagglutinin during viral entry into host cells, while C-4 and C-2 hydroxy were not critical for the binding process and could be replaced with hydrophobic moieties.	N-Acetylneuraminic Acid	68-79	complement C9	Homo sapiens	53-56
28509534-0	2017	Analysis of Three Epoetin Alpha Products by LC and LC-MS Indicates Differences in Glycosylation Critical Quality Attributes, Including Sialic Acid Content.	N-Acetylneuraminic Acid	135-146	erythropoietin	Homo sapiens	18-25
28500071-2	2017	Galectin-3 (Gal-3) can cross-link surface glycoproteins by binding galactose residues that are normally hidden below terminal sialic acid residues.	N-Acetylneuraminic Acid	126-137	galectin 3	Rattus norvegicus	0-10
28500071-2	2017	Galectin-3 (Gal-3) can cross-link surface glycoproteins by binding galactose residues that are normally hidden below terminal sialic acid residues.	N-Acetylneuraminic Acid	126-137	galectin 3	Rattus norvegicus	12-17
28454648-2	2017	Siglec-5 and Siglec-14 are members of the sialic-acid binding lectin family that regulate immune responses to pathogens through inhibitory (Siglec-5) and activating (Siglec-14) domains.	N-Acetylneuraminic Acid	42-53	sialic acid binding Ig like lectin 5	Homo sapiens	0-8
28273363-1	2017	Sialic acid-binding Ig-like lectin-9 (Siglec-9) is a novel sialic acid-binding member of the immunoglobulin superfamily and is broadly expressed on immune cells, which can inhibit both innate and adaptive immune responses through immunoreceptor tyrosine-based inhibitory motifs.	N-Acetylneuraminic Acid	59-70	sialic acid binding Ig like lectin 9	Homo sapiens	0-36
28273363-1	2017	Sialic acid-binding Ig-like lectin-9 (Siglec-9) is a novel sialic acid-binding member of the immunoglobulin superfamily and is broadly expressed on immune cells, which can inhibit both innate and adaptive immune responses through immunoreceptor tyrosine-based inhibitory motifs.	N-Acetylneuraminic Acid	59-70	sialic acid binding Ig like lectin 9	Homo sapiens	38-46
28740545-0	2017	E-selectin-targeted Sialic Acid-PEG-dexamethasone Micelles for Enhanced Anti-Inflammatory Efficacy for Acute Kidney Injury.	N-Acetylneuraminic Acid	20-31	selectin E	Homo sapiens	0-10
28740545-2	2017	Sialic acid (SA) is main component of Sialyl Lewisx antigen on the mammalian cell surface, which participates in E-selectin binding.	N-Acetylneuraminic Acid	0-11	selectin E	Homo sapiens	113-123
28740545-2	2017	Sialic acid (SA) is main component of Sialyl Lewisx antigen on the mammalian cell surface, which participates in E-selectin binding.	N-Acetylneuraminic Acid	13-15	selectin E	Homo sapiens	113-123
28740545-3	2017	Therefore, dexamethasone(DXM)-loaded E-selectin-targeting sialic acid-polyethylene glycol-dexamethasone (SA-PEG-DXM/DXM) conjugate micelles are designed for ameliorating AKI.	N-Acetylneuraminic Acid	58-69	selectin E	Homo sapiens	37-47
28740545-7	2017	Much more SA-PEG-DXM micelles can be internalized by lipopolysaccharide (LPS)-activated human umbilical vein endothelial cells (HUVECs) in comparison to PEG-DXM micelles due to specific interaction between SA and E-selectin expressed on HUVECs, and consequently more SA-PEG-DXM micelles are accumulated in the kidney of AKI murine model.	N-Acetylneuraminic Acid	10-12	selectin E	Homo sapiens	213-223
28740545-8	2017	Furthermore, SA in SA-PEG-DXM conjugates can significantly ameliorate LPS-induced production of pro-inflammatory cytokines via suppressing LPS-activated Beclin-1/Atg5-Atg12-mediated autophagy to attenuate toxicity.	N-Acetylneuraminic Acid	13-15	beclin 1	Homo sapiens	153-161
28740545-8	2017	Furthermore, SA in SA-PEG-DXM conjugates can significantly ameliorate LPS-induced production of pro-inflammatory cytokines via suppressing LPS-activated Beclin-1/Atg5-Atg12-mediated autophagy to attenuate toxicity.	N-Acetylneuraminic Acid	13-15	autophagy related 5	Homo sapiens	162-166
28740545-8	2017	Furthermore, SA in SA-PEG-DXM conjugates can significantly ameliorate LPS-induced production of pro-inflammatory cytokines via suppressing LPS-activated Beclin-1/Atg5-Atg12-mediated autophagy to attenuate toxicity.	N-Acetylneuraminic Acid	13-15	autophagy related 12	Homo sapiens	167-172
28546570-0	2017	Corrigendum: NANS-mediated synthesis of sialic acid is required for brain and skeletal development.	N-Acetylneuraminic Acid	40-51	N-acetylneuraminate synthase	Homo sapiens	13-17
28189729-1	2017	Slc17a5-/- mice represent an animal model for the infantile form of sialic acid storage disease (SASD).	N-Acetylneuraminic Acid	68-79	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	0-7
28189729-3	2017	Sialin-deficient mice display a distinct spatiotemporal pattern of sialic acid storage, CNS hypomyelination and leukoencephalopathy.	N-Acetylneuraminic Acid	67-78	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	0-6
28012129-2	2017	CD24, a mucin-like glycoprotein expressed at the surface of hematopoietic cells and diverse tumor cells, is known to interact with the sialic acid-binding immunoglobulin-type lectins (Siglecs).	N-Acetylneuraminic Acid	135-146	CD24 molecule	Homo sapiens	0-4
28454648-2	2017	Siglec-5 and Siglec-14 are members of the sialic-acid binding lectin family that regulate immune responses to pathogens through inhibitory (Siglec-5) and activating (Siglec-14) domains.	N-Acetylneuraminic Acid	42-53	sialic acid binding Ig like lectin 14	Homo sapiens	166-175
28315686-1	2017	Anti-bacterial and anti-viral neuraminidase agents inhibit neuraminidase activity catalyzing the hydrolysis of terminal N-acetylneuraminic acid (Neu5Ac) from glycoconjugates and help to prevent the host pathogenesis that lead to fatal infectious diseases including influenza, bacteremia, sepsis, and cholera.	N-Acetylneuraminic Acid	120-143	neuraminidase 1	Homo sapiens	59-72
28424265-3	2017	GNE harbors two enzymatic activities required for biosynthesis of sialic acid in mammalian cells.	N-Acetylneuraminic Acid	66-77	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
28416510-7	2017	By enzyme-linked immunosorbent assay and immunofluorescence, we found that glycophorin A, the most abundant sialoglycoprotein on erythrocytes, engaged neutrophil Siglec-9, a sialic acid-recognizing receptor known to dampen innate immune cell activation.	N-Acetylneuraminic Acid	174-185	glycophorin A (MNS blood group)	Homo sapiens	75-88
28370891-3	2017	Terminal sialic acid on the metalloprotease domain glycans are important for ADAMTS-13 activity.	N-Acetylneuraminic Acid	9-20	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	77-86
28370891-10	2017	Using truncated ADAMTS-13, we demonstrated that this was attributable to loss of sialic acid from the glycans in the metalloprotease domain and an effect of N-linked glycosylation in the TSP2 through to CUB domains.	N-Acetylneuraminic Acid	81-92	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	16-25
28315686-1	2017	Anti-bacterial and anti-viral neuraminidase agents inhibit neuraminidase activity catalyzing the hydrolysis of terminal N-acetylneuraminic acid (Neu5Ac) from glycoconjugates and help to prevent the host pathogenesis that lead to fatal infectious diseases including influenza, bacteremia, sepsis, and cholera.	N-Acetylneuraminic Acid	120-143	neuraminidase 1	Homo sapiens	30-43
28315686-1	2017	Anti-bacterial and anti-viral neuraminidase agents inhibit neuraminidase activity catalyzing the hydrolysis of terminal N-acetylneuraminic acid (Neu5Ac) from glycoconjugates and help to prevent the host pathogenesis that lead to fatal infectious diseases including influenza, bacteremia, sepsis, and cholera.	N-Acetylneuraminic Acid	145-151	neuraminidase 1	Homo sapiens	30-43
28315686-1	2017	Anti-bacterial and anti-viral neuraminidase agents inhibit neuraminidase activity catalyzing the hydrolysis of terminal N-acetylneuraminic acid (Neu5Ac) from glycoconjugates and help to prevent the host pathogenesis that lead to fatal infectious diseases including influenza, bacteremia, sepsis, and cholera.	N-Acetylneuraminic Acid	145-151	neuraminidase 1	Homo sapiens	59-72
28454648-2	2017	Siglec-5 and Siglec-14 are members of the sialic-acid binding lectin family that regulate immune responses to pathogens through inhibitory (Siglec-5) and activating (Siglec-14) domains.	N-Acetylneuraminic Acid	42-53	sialic acid binding Ig like lectin 14	Homo sapiens	13-22
28454648-2	2017	Siglec-5 and Siglec-14 are members of the sialic-acid binding lectin family that regulate immune responses to pathogens through inhibitory (Siglec-5) and activating (Siglec-14) domains.	N-Acetylneuraminic Acid	42-53	sialic acid binding Ig like lectin 5	Homo sapiens	140-148
28216300-11	2017	This phenylboronic acid-sialic acid interaction may provide additional tumor targeting and penetration potentials together with an enhanced permeability and retention (EPR) effect (passive tumor targeting) and HA-CD44 receptor interaction (active tumor targeting).	N-Acetylneuraminic Acid	24-35	CD44 molecule (Indian blood group)	Homo sapiens	213-217
28111290-5	2017	Neu1 exhibited desialylation of alpha2-3 sialic acid linkage in vitro and lysosomal localization in medaka caudal fin primary cells.	N-Acetylneuraminic Acid	41-52	sialidase-1	Oryzias latipes	0-4
28205451-4	2017	Furthermore, our findings suggest that the interaction between the sialic acid LPS moieties and the inhibitory CD33 receptor is prevented by endogenously expressed sialic acid on the surface of THP-1 cells that cannot be out-competed by sialic acid containing P. gingivalis LPS.	N-Acetylneuraminic Acid	67-78	CD33 molecule	Homo sapiens	111-115
28205451-4	2017	Furthermore, our findings suggest that the interaction between the sialic acid LPS moieties and the inhibitory CD33 receptor is prevented by endogenously expressed sialic acid on the surface of THP-1 cells that cannot be out-competed by sialic acid containing P. gingivalis LPS.	N-Acetylneuraminic Acid	164-175	CD33 molecule	Homo sapiens	111-115
28205451-4	2017	Furthermore, our findings suggest that the interaction between the sialic acid LPS moieties and the inhibitory CD33 receptor is prevented by endogenously expressed sialic acid on the surface of THP-1 cells that cannot be out-competed by sialic acid containing P. gingivalis LPS.	N-Acetylneuraminic Acid	164-175	CD33 molecule	Homo sapiens	111-115
28325905-9	2017	While C1q binds CD33C2 domains, decreased C1q-CD33 interactions resulting from sialic acid masking of CD33C2 domains suggests a process for regulating C1q-CD33 activity.	N-Acetylneuraminic Acid	79-90	complement C1q A chain	Homo sapiens	42-45
28325905-9	2017	While C1q binds CD33C2 domains, decreased C1q-CD33 interactions resulting from sialic acid masking of CD33C2 domains suggests a process for regulating C1q-CD33 activity.	N-Acetylneuraminic Acid	79-90	complement C1q A chain	Homo sapiens	42-45
28325905-9	2017	While C1q binds CD33C2 domains, decreased C1q-CD33 interactions resulting from sialic acid masking of CD33C2 domains suggests a process for regulating C1q-CD33 activity.	N-Acetylneuraminic Acid	79-90	CD33 molecule	Homo sapiens	46-50
28213516-7	2017	Sialidase activity visualized with a benzothiazolylphenol-based sialic acid derivative (BTP3-Neu5Ac), a highly sensitive histochemical imaging probe for sialidase activity, at the CA3 stratum lucidum of rat acute hippocampal slices was immediately increased in response to LTP-inducible high-frequency stimulation on a time scale of seconds.	N-Acetylneuraminic Acid	64-75	carbonic anhydrase 3	Rattus norvegicus	180-183
28386256-7	2017	In particular, the sialic acid residues present on gp120 can bind Siglec-7 on natural killer and monocytes/macrophages and Siglec-1 on monocytes/macrophages and dendritic cells.	N-Acetylneuraminic Acid	19-30	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	51-56
28386256-7	2017	In particular, the sialic acid residues present on gp120 can bind Siglec-7 on natural killer and monocytes/macrophages and Siglec-1 on monocytes/macrophages and dendritic cells.	N-Acetylneuraminic Acid	19-30	sialic acid binding Ig like lectin 7	Homo sapiens	66-74
28386256-7	2017	In particular, the sialic acid residues present on gp120 can bind Siglec-7 on natural killer and monocytes/macrophages and Siglec-1 on monocytes/macrophages and dendritic cells.	N-Acetylneuraminic Acid	19-30	sialic acid binding Ig like lectin 1	Homo sapiens	123-131
28194834-7	2017	Furthermore, glycoengineered cells carrying sialic acid ligands for Siglec-3 dampened the activation of Siglec-3+ monocytic cells through the NF-kappaB and IRF pathways.	N-Acetylneuraminic Acid	44-55	CD33 molecule	Homo sapiens	68-76
28194834-7	2017	Furthermore, glycoengineered cells carrying sialic acid ligands for Siglec-3 dampened the activation of Siglec-3+ monocytic cells through the NF-kappaB and IRF pathways.	N-Acetylneuraminic Acid	44-55	CD33 molecule	Homo sapiens	104-112
28194834-7	2017	Furthermore, glycoengineered cells carrying sialic acid ligands for Siglec-3 dampened the activation of Siglec-3+ monocytic cells through the NF-kappaB and IRF pathways.	N-Acetylneuraminic Acid	44-55	tripartite motif containing 63	Homo sapiens	156-159
28267778-0	2017	Substantial deficiency of free sialic acid in muscles of patients with GNE myopathy and in a mouse model.	N-Acetylneuraminic Acid	31-42	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	71-74
28267778-1	2017	GNE myopathy (GNEM), also known as hereditary inclusion body myopathy (HIBM), is a late- onset, progressive myopathy caused by mutations in the GNE gene encoding the enzyme responsible for the first regulated step in the biosynthesis of sialic acid (SA).	N-Acetylneuraminic Acid	237-248	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
28267778-1	2017	GNE myopathy (GNEM), also known as hereditary inclusion body myopathy (HIBM), is a late- onset, progressive myopathy caused by mutations in the GNE gene encoding the enzyme responsible for the first regulated step in the biosynthesis of sialic acid (SA).	N-Acetylneuraminic Acid	237-248	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	14-17
28267778-1	2017	GNE myopathy (GNEM), also known as hereditary inclusion body myopathy (HIBM), is a late- onset, progressive myopathy caused by mutations in the GNE gene encoding the enzyme responsible for the first regulated step in the biosynthesis of sialic acid (SA).	N-Acetylneuraminic Acid	250-252	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
28267778-1	2017	GNE myopathy (GNEM), also known as hereditary inclusion body myopathy (HIBM), is a late- onset, progressive myopathy caused by mutations in the GNE gene encoding the enzyme responsible for the first regulated step in the biosynthesis of sialic acid (SA).	N-Acetylneuraminic Acid	250-252	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	14-17
28267778-12	2017	These results show that serum and muscle free SA is severely reduced in GNEM, which is consistent with the biochemical defect in SA synthesis associated with GNE mutations.	N-Acetylneuraminic Acid	46-48	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	72-75
28267778-12	2017	These results show that serum and muscle free SA is severely reduced in GNEM, which is consistent with the biochemical defect in SA synthesis associated with GNE mutations.	N-Acetylneuraminic Acid	129-131	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	72-75
28187749-0	2017	Identification of a large intronic transposal insertion in SLC17A5 causing sialic acid storage disease.	N-Acetylneuraminic Acid	75-86	solute carrier family 17 member 5	Homo sapiens	59-66
28049733-2	2017	The major sialic acids in most mammalian tissues are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), the latter being derived from Neu5Ac via addition of one oxygen atom at the sugar nucleotide level by CMP-Neu5Ac hydroxylase (Cmah).	N-Acetylneuraminic Acid	156-162	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	228-250
28049733-2	2017	The major sialic acids in most mammalian tissues are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc), the latter being derived from Neu5Ac via addition of one oxygen atom at the sugar nucleotide level by CMP-Neu5Ac hydroxylase (Cmah).	N-Acetylneuraminic Acid	156-162	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	252-256
27642072-9	2017	Slc35a1 is responsible for transporting sialic acid into the Golgi.	N-Acetylneuraminic Acid	40-51	solute carrier family 35 member A1	Homo sapiens	0-7
27642072-11	2017	The complete absence of sialic acid on the Slc35a1 knockout cell line led to complete resistance to MVM infection.	N-Acetylneuraminic Acid	24-35	solute carrier family 35 member A1	Homo sapiens	43-50
27642072-12	2017	The Cosmc and Mgat1 knockouts also show significant inhibition of infection likely due to their effect on decreasing cell surface sialic acid.	N-Acetylneuraminic Acid	130-141	C1GALT1 specific chaperone 1	Homo sapiens	4-9
27642072-12	2017	The Cosmc and Mgat1 knockouts also show significant inhibition of infection likely due to their effect on decreasing cell surface sialic acid.	N-Acetylneuraminic Acid	130-141	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	14-19
28258691-3	2017	CD169 is a Siglec that may function as an adhesion molecule and a facilitator of the recognition and internalization of sialic acid decorated apoptotic bodies and exosomes derived from tumors.	N-Acetylneuraminic Acid	120-131	sialic acid binding Ig like lectin 1	Homo sapiens	0-5
28382168-2	2017	Sialic acid (N-acetylneuraminic acid, Neu5Ac) is recognized as a "self" marker by major serum protein complement factor H and shows reduced interaction with the innate immune system via sialic acid-binding immunoglobulin-like lectin (Siglec), which is known as one of the significant regulators of phagocytic evasion.	N-Acetylneuraminic Acid	0-11	complement factor H	Homo sapiens	113-121
28382168-2	2017	Sialic acid (N-acetylneuraminic acid, Neu5Ac) is recognized as a "self" marker by major serum protein complement factor H and shows reduced interaction with the innate immune system via sialic acid-binding immunoglobulin-like lectin (Siglec), which is known as one of the significant regulators of phagocytic evasion.	N-Acetylneuraminic Acid	13-36	complement factor H	Homo sapiens	113-121
28382168-2	2017	Sialic acid (N-acetylneuraminic acid, Neu5Ac) is recognized as a "self" marker by major serum protein complement factor H and shows reduced interaction with the innate immune system via sialic acid-binding immunoglobulin-like lectin (Siglec), which is known as one of the significant regulators of phagocytic evasion.	N-Acetylneuraminic Acid	38-44	complement factor H	Homo sapiens	113-121
28391889-3	2017	ApoC-III is a glycosylated apolipoprotein, with 3 major glycoforms: apoC-III0, apoC-III1, and apoC-III2 that contain 0, 1, or 2 molecules of sialic acid, respectively.	N-Acetylneuraminic Acid	141-152	apolipoprotein C3	Homo sapiens	0-8
28103033-6	2017	They display up to a 5000-fold enhanced affinity over the unmodified sialic acid scaffold alphaMe Neu5Ac, the smallest known natural Siglec-7 ligand.	N-Acetylneuraminic Acid	69-80	sialic acid binding Ig like lectin 7	Homo sapiens	133-141
27829678-1	2017	GNE myopathy is an autosomal recessive distal myopathy caused by loss-of-function mutations in the GNE gene, which encodes UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE), a key enzyme in sialic-acid biosynthesis.	N-Acetylneuraminic Acid	183-194	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
27829678-1	2017	GNE myopathy is an autosomal recessive distal myopathy caused by loss-of-function mutations in the GNE gene, which encodes UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE), a key enzyme in sialic-acid biosynthesis.	N-Acetylneuraminic Acid	183-194	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	99-102
27829678-1	2017	GNE myopathy is an autosomal recessive distal myopathy caused by loss-of-function mutations in the GNE gene, which encodes UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE), a key enzyme in sialic-acid biosynthesis.	N-Acetylneuraminic Acid	183-194	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	99-102
28103033-5	2017	The compounds are Sialic acid derivatives and bind with low micromolar Kd values to Siglec-7.	N-Acetylneuraminic Acid	18-29	sialic acid binding Ig like lectin 7	Homo sapiens	84-92
28101903-7	2017	Flow cytometric analysis revealed that the minimum hPDPN epitope, in which sialic acid is linked to Thr76, recognized by LpMab-21 is Thr76-Arg79.	N-Acetylneuraminic Acid	75-86	podoplanin	Homo sapiens	51-56
28232658-2	2017	GNE gene, which encodes for a key enzyme in the sialic acid biosynthesis pathway, is mutated in the homozygote or compound heterozygote in the disease.	N-Acetylneuraminic Acid	48-59	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	0-3
28232658-3	2017	The lack of sialic acid in skeletal muscle is the critical pathological process in GNE myopathy.	N-Acetylneuraminic Acid	12-23	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	83-86
28232658-4	2017	GNE myopathy model mouse was established and supplementation of sialic acid improves the phenotype of model mouse.	N-Acetylneuraminic Acid	64-75	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	0-3
27683310-2	2017	ST3Gal-II (coded by the St3gal2 gene) transfers sialic acid preferentially to the three positions of galactose on the Galbeta1-3GalNAc terminus of gangliosides GM1 and GD1b to synthesize GD1a and GT1b, respectively.	N-Acetylneuraminic Acid	48-59	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Mus musculus	0-9
27683310-2	2017	ST3Gal-II (coded by the St3gal2 gene) transfers sialic acid preferentially to the three positions of galactose on the Galbeta1-3GalNAc terminus of gangliosides GM1 and GD1b to synthesize GD1a and GT1b, respectively.	N-Acetylneuraminic Acid	48-59	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Mus musculus	24-31
27683310-2	2017	ST3Gal-II (coded by the St3gal2 gene) transfers sialic acid preferentially to the three positions of galactose on the Galbeta1-3GalNAc terminus of gangliosides GM1 and GD1b to synthesize GD1a and GT1b, respectively.	N-Acetylneuraminic Acid	48-59	coenzyme Q10A	Mus musculus	160-163
28138305-10	2017	Results: Both turbidity and kinematic viscosity and sialic acid content increased linearly as the hardness of mucin increased.	N-Acetylneuraminic Acid	52-63	LOC100508689	Homo sapiens	110-115
27924345-1	2016	para-Nitrophenol (pNP)-tagged alpha2-8-linked sialosides containing different sialic acid forms were chemoenzymatically synthesized using an efficient one-pot three-enzyme alpha2-8-sialylation system.	N-Acetylneuraminic Acid	78-89	immunoglobulin binding protein 1	Homo sapiens	30-38
27714850-1	2016	Human and bovine group B streptococcus (GBS) isolates were serotyped and amounts of released N-acetylneuraminic acid from N-acetylneuraminyl-lactose by extracellular neuraminidase were colorimetrically assessed.	N-Acetylneuraminic Acid	93-116	neuraminidase 1	Homo sapiens	166-179
28018341-6	2016	In addition, removal of sialic acid from the cell surface by neuraminidase treatment impairs ERK1/2 activation by CCL21, but not by CCL19 or tailless-CCL21.	N-Acetylneuraminic Acid	24-35	neuraminidase 1	Homo sapiens	61-74
28018341-6	2016	In addition, removal of sialic acid from the cell surface by neuraminidase treatment impairs ERK1/2 activation by CCL21, but not by CCL19 or tailless-CCL21.	N-Acetylneuraminic Acid	24-35	mitogen-activated protein kinase 3	Homo sapiens	93-99
28018341-6	2016	In addition, removal of sialic acid from the cell surface by neuraminidase treatment impairs ERK1/2 activation by CCL21, but not by CCL19 or tailless-CCL21.	N-Acetylneuraminic Acid	24-35	C-C motif chemokine ligand 21	Homo sapiens	114-119
27809484-9	2016	A glycan on MUC5AC that is associated with cancer had mostly 2,3-linked sialic acid, whereas other glycans on MUC5AC had a 2,6 linkage of sialic acid.	N-Acetylneuraminic Acid	72-83	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	12-18
27986075-1	2016	BACKGROUND: Sialyltransferase I (ST6Gal-I) is an enzyme involved in tumor metastasis that processes sialic acid precursors into their mature form, enabling them to regulate gene expression.	N-Acetylneuraminic Acid	100-111	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	33-41
27793989-4	2016	In support of this possibility, unbiased molecular docking studies revealed that negatively charged alpha2,3 sialic acid moieties bind tightly to a groove within the PECAM-1 homophilic interface in an orientation that favors the formation of an electrostatic bridge with positively charged Lys-89, mutation of which has been shown previously to disrupt PECAM-1-mediated homophilic binding.	N-Acetylneuraminic Acid	109-120	platelet and endothelial cell adhesion molecule 1	Homo sapiens	166-173
27793989-4	2016	In support of this possibility, unbiased molecular docking studies revealed that negatively charged alpha2,3 sialic acid moieties bind tightly to a groove within the PECAM-1 homophilic interface in an orientation that favors the formation of an electrostatic bridge with positively charged Lys-89, mutation of which has been shown previously to disrupt PECAM-1-mediated homophilic binding.	N-Acetylneuraminic Acid	109-120	platelet and endothelial cell adhesion molecule 1	Homo sapiens	353-360
27793989-7	2016	Taken together, these data suggest that a sialic acid-containing glycan emanating from Asn-25 reinforces dynamic endothelial cell-cell interactions by stabilizing the PECAM-1 homophilic binding interface.	N-Acetylneuraminic Acid	42-53	platelet and endothelial cell adhesion molecule 1	Homo sapiens	167-174
27424943-4	2016	These two glycoproteins both recognize the sialic acid and have complementary activities, the HA binds the sialic acid through its receptor-binding site, the NA is a receptor-destroying enzyme that cleaves alpha2-3 and alpha2-6-linked sialic acids.	N-Acetylneuraminic Acid	107-118	immunoglobulin binding protein 1	Homo sapiens	219-227
27847205-7	2016	Blockade of alpha2,6 sialic acid expression on Hca-F cell surface by the treatment with neuraminidase caused reduction in cellular adherence to lymph node.	N-Acetylneuraminic Acid	21-32	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	12-20
26674359-1	2016	OBJECTIVE: Sialic-acid-binding immunoglobulin-like lectin-7 (Siglec-7) is a natural killer (NK) cell inhibitory receptor associated with NK phenotypic and functional abnormalities in HIV-1 infection.	N-Acetylneuraminic Acid	11-22	sialic acid binding Ig like lectin 7	Homo sapiens	61-69
27387429-1	2016	The human Golgi Cytidine-5"-monophospho-N-acetylneuraminic acid (CMP-Sia) transporter SLC35A1, a member of the nucleotide sugar transporter family, translocates CMP-Sia from the cytosol into the Golgi lumen where sialyltransferases use it as donor substrate for the synthesis of sialoglycoconjugates.	N-Acetylneuraminic Acid	42-63	solute carrier family 35 member A1	Homo sapiens	86-93
27943302-1	2016	N-Acetylneuraminate lyase is the first committed enzyme in the degradation of sialic acid by bacterial pathogens.	N-Acetylneuraminic Acid	78-89	AT695_RS02220	Staphylococcus aureus	0-25
27943302-4	2016	Our data indicate that sialic acid alditol, a known inhibitor of N-acetylneuraminate lyase enzymes, is a stronger inhibitor of MRSA N-acetylneuraminate lyase than of Clostridium perfringens N-acetylneuraminate lyase.	N-Acetylneuraminic Acid	23-34	AT695_RS02220	Staphylococcus aureus	65-90
27943302-4	2016	Our data indicate that sialic acid alditol, a known inhibitor of N-acetylneuraminate lyase enzymes, is a stronger inhibitor of MRSA N-acetylneuraminate lyase than of Clostridium perfringens N-acetylneuraminate lyase.	N-Acetylneuraminic Acid	23-34	AT695_RS02220	Staphylococcus aureus	132-157
27943302-4	2016	Our data indicate that sialic acid alditol, a known inhibitor of N-acetylneuraminate lyase enzymes, is a stronger inhibitor of MRSA N-acetylneuraminate lyase than of Clostridium perfringens N-acetylneuraminate lyase.	N-Acetylneuraminic Acid	23-34	AT695_RS02220	Staphylococcus aureus	132-157
27943302-5	2016	Our analysis of the crystal structure of ligand-free and 2R-sialic acid alditol-bound MRSA N-acetylneuraminate lyase suggests that subtle dynamic differences in solution and/or altered binding interactions within the active site may account for species-specific inhibition.	N-Acetylneuraminic Acid	60-71	AT695_RS02220	Staphylococcus aureus	91-116
27892504-2	2016	PSGL1 is highly sialylated, making it a potential ligand for Siglec-5, a leukocyte-receptor that recognizes sialic acid structures.	N-Acetylneuraminic Acid	108-119	selectin, platelet (p-selectin) ligand	Mus musculus	0-5
27443851-11	2016	We show that the ape EBA-140 Region II is host specific and binds to chimpanzee erythrocytes in the dose and sialic acid dependent manner.	N-Acetylneuraminic Acid	109-120	PRSY57_1300500	Plasmodium reichenowi	21-28
26920336-0	2016	Sweet characterisation of prostate specific antigen using electrochemical lectin-based immunosensor assay and MALDI TOF/TOF analysis: Focus on sialic acid.	N-Acetylneuraminic Acid	143-154	kallikrein related peptidase 3	Homo sapiens	26-51
26920336-3	2016	The biosensor showed presence of alpha-L-fucose and alpha-(2,6)-linked terminal sialic acid within PSA s glycan with high abundance, while only traces of alpha-(2,3)-linked terminal sialic acid were found.	N-Acetylneuraminic Acid	80-91	kallikrein related peptidase 3	Homo sapiens	99-102
26920336-4	2016	MALDI TOF/TOF mass spectrometry was applied to validate results obtained by the biosensor with a focus on determination of a type of sialic acid linkage by two methods.	N-Acetylneuraminic Acid	133-144	FEZ family zinc finger 2	Homo sapiens	6-9
26920336-4	2016	MALDI TOF/TOF mass spectrometry was applied to validate results obtained by the biosensor with a focus on determination of a type of sialic acid linkage by two methods.	N-Acetylneuraminic Acid	133-144	FEZ family zinc finger 2	Homo sapiens	10-13
27893774-1	2016	Sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) on leukocyte surface is a counter-receptor for endothelial cell surface adhesin, human primary amine oxidase (hAOC3), a target protein for anti-inflammatory agents.	N-Acetylneuraminic Acid	0-11	sialic acid binding Ig like lectin 9	Homo sapiens	50-58
27893774-1	2016	Sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) on leukocyte surface is a counter-receptor for endothelial cell surface adhesin, human primary amine oxidase (hAOC3), a target protein for anti-inflammatory agents.	N-Acetylneuraminic Acid	0-11	amine oxidase copper containing 3	Homo sapiens	170-175
27893774-7	2016	Furthermore, the C22 domain binding enhances the enzymatic activity of hAOC3 although the sialic acid-binding capacity of the V domain of Siglec-9 is abolished by the R120S mutation.	N-Acetylneuraminic Acid	90-101	amine oxidase copper containing 3	Homo sapiens	71-76
27892504-2	2016	PSGL1 is highly sialylated, making it a potential ligand for Siglec-5, a leukocyte-receptor that recognizes sialic acid structures.	N-Acetylneuraminic Acid	108-119	sialic acid binding Ig-like lectin F	Mus musculus	61-69
27893774-7	2016	Furthermore, the C22 domain binding enhances the enzymatic activity of hAOC3 although the sialic acid-binding capacity of the V domain of Siglec-9 is abolished by the R120S mutation.	N-Acetylneuraminic Acid	90-101	sialic acid binding Ig like lectin 9	Homo sapiens	138-146
27567275-5	2016	Anti-Neu5Gc, found only in humans, appeared in hominins &lt;6 mya, following elimination of N-glycolylneuraminic-acid (Neu5Gc) because of inactivation of CMAH, the gene encoding hydroxylase that converts N-acetylneuraminic-acid (Neu5Ac) into Neu5Gc.	N-Acetylneuraminic Acid	204-227	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	154-158
27661071-7	2016	Investigation of the effect of diquafosol solution (3%) in normal subjects revealed a significant increase in sialic acid concentration, a marker of ocular mucin, at 5 minutes after application, whereas a significant decrease was observed with saline.	N-Acetylneuraminic Acid	110-121	LOC100508689	Homo sapiens	156-161
27567275-5	2016	Anti-Neu5Gc, found only in humans, appeared in hominins &lt;6 mya, following elimination of N-glycolylneuraminic-acid (Neu5Gc) because of inactivation of CMAH, the gene encoding hydroxylase that converts N-acetylneuraminic-acid (Neu5Ac) into Neu5Gc.	N-Acetylneuraminic Acid	229-235	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	154-158
27595232-1	2016	Siglec-9 is a sialic-acid-binding lectin expressed predominantly on myeloid cells.	N-Acetylneuraminic Acid	14-25	sialic acid binding Ig like lectin 9	Homo sapiens	0-8
27680668-3	2016	The central, long mucin domain of lubricin is extensively O-glycosylated with Gal(beta1-3)GalNAc-O-Ser/Thr, and about two thirds of the O-glycosylated sites are capped with sialic acid.	N-Acetylneuraminic Acid	173-184	LOC100508689	Homo sapiens	18-23
27680668-3	2016	The central, long mucin domain of lubricin is extensively O-glycosylated with Gal(beta1-3)GalNAc-O-Ser/Thr, and about two thirds of the O-glycosylated sites are capped with sialic acid.	N-Acetylneuraminic Acid	173-184	proteoglycan 4	Homo sapiens	34-42
27680668-4	2016	Our aim was to determine whether removal of sialic acid by sialidase could improve the detection of lubricin in a number of human tissues using the S6.79 monoclonal antibody.	N-Acetylneuraminic Acid	44-55	proteoglycan 4	Homo sapiens	100-108
27783694-2	2016	Sialidase (EC 3.2.1.18), which has 4 isozymes including Neu1, Neu2, Neu3 and Neu4, regulates the sialylation level of glycans by removing sialic acid from sialylglycoconjugate.	N-Acetylneuraminic Acid	138-149	neuraminidase 4	Rattus norvegicus	77-81
27783694-2	2016	Sialidase (EC 3.2.1.18), which has 4 isozymes including Neu1, Neu2, Neu3 and Neu4, regulates the sialylation level of glycans by removing sialic acid from sialylglycoconjugate.	N-Acetylneuraminic Acid	138-149	neuraminidase 1	Rattus norvegicus	56-60
27783694-2	2016	Sialidase (EC 3.2.1.18), which has 4 isozymes including Neu1, Neu2, Neu3 and Neu4, regulates the sialylation level of glycans by removing sialic acid from sialylglycoconjugate.	N-Acetylneuraminic Acid	138-149	neuraminidase 2	Rattus norvegicus	62-66
27506346-7	2016	The results showed that Maackia amurensis agglutinin (MAA) recognizing alpha-2,3-terminal sialic acid can be applied to distinguish between these two sets of samples since the MAA/PSA response obtained from the analysis of the PCa samples was significantly higher (5.3-fold) compared to the MAA/PSA response obtained by the analysis of samples from healthy individuals.	N-Acetylneuraminic Acid	90-101	kallikrein related peptidase 3	Homo sapiens	180-183
27783694-2	2016	Sialidase (EC 3.2.1.18), which has 4 isozymes including Neu1, Neu2, Neu3 and Neu4, regulates the sialylation level of glycans by removing sialic acid from sialylglycoconjugate.	N-Acetylneuraminic Acid	138-149	neuraminidase 3	Rattus norvegicus	68-72
27537280-0	2016	Detection of mSiglec-E, in solution and expressed on the surface of Chinese hamster ovary cells, using sialic acid functionalised gold nanoparticles.	N-Acetylneuraminic Acid	103-114	sialic acid binding Ig-like lectin E	Mus musculus	13-22
27537280-6	2016	The gold nanoparticles were functionalised with various ratios of sialic acid : PEG ligands and the optimum ratio for the detection of murine Siglec-E was established based on the plasmonic detection of the soluble pre-complexed recombinant form of murine Siglec-E (mSiglec-E-Fc fusion protein).	N-Acetylneuraminic Acid	66-77	sialic acid binding Ig-like lectin E	Mus musculus	142-150
27678199-1	2016	Sialic acid (Sia) binding immunoglobulin (Ig)-like lectin-5 (Siglec-5) is a type-I transmembrane protein, and it has been demonstrated as a biomarker of granulocytic maturation and acute myeloid leukemia phenotype.	N-Acetylneuraminic Acid	0-11	sialic acid binding Ig like lectin 5	Homo sapiens	61-69
27678199-1	2016	Sialic acid (Sia) binding immunoglobulin (Ig)-like lectin-5 (Siglec-5) is a type-I transmembrane protein, and it has been demonstrated as a biomarker of granulocytic maturation and acute myeloid leukemia phenotype.	N-Acetylneuraminic Acid	0-3	sialic acid binding Ig like lectin 5	Homo sapiens	61-69
27624073-2	2016	Two kinds of the sialic acid-presenting Lactosomes targeting the immunosuppressive receptors of Siglec-G and CD22 have been successfully prepared.	N-Acetylneuraminic Acid	17-28	CD22 molecule	Homo sapiens	109-113
27647907-7	2016	Inhibition of this second molecular bridge, through the use of an F(ab")2 or the mutation of the sialic acid-binding site, renders the Fc-FcgammaR interaction unable to optimally activate effector cells.	N-Acetylneuraminic Acid	97-108	Fc gamma receptor Ia	Homo sapiens	138-146
27664951-3	2016	Aims of this study was to examine the influence of tobacco smoking on transferrin sialic acid residues and their connection with fetal biometric parameters in women with iron-deficiency.	N-Acetylneuraminic Acid	82-93	transferrin	Homo sapiens	70-81
27513956-0	2016	RNase activity of sialic acid-binding lectin from bullfrog eggs drives antitumor effect via the activation of p38 MAPK to caspase-3/7 signaling pathway in human breast cancer cells.	N-Acetylneuraminic Acid	18-29	caspase 7	Homo sapiens	122-133
27150510-4	2016	ST3Gal1 and 2 and previously cloned ST3Gal3 and 6 transferred CMP-sialic acid to asialofetuin.	N-Acetylneuraminic Acid	66-77	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Gallus gallus	0-13
27150510-4	2016	ST3Gal1 and 2 and previously cloned ST3Gal3 and 6 transferred CMP-sialic acid to asialofetuin.	N-Acetylneuraminic Acid	66-77	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Gallus gallus	36-43
27593514-3	2016	Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac.	N-Acetylneuraminic Acid	104-107	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	29-87
27593514-3	2016	Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac.	N-Acetylneuraminic Acid	104-107	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	89-93
27593514-3	2016	Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac.	N-Acetylneuraminic Acid	52-75	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	89-93
27593514-3	2016	Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac.	N-Acetylneuraminic Acid	52-75	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	206-210
27593514-3	2016	Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac.	N-Acetylneuraminic Acid	133-139	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	29-87
27593514-3	2016	Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac.	N-Acetylneuraminic Acid	133-139	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	89-93
27593514-3	2016	Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac.	N-Acetylneuraminic Acid	133-139	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	206-210
27593514-3	2016	Unlike most animals in which cytidine-monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts Sia N-acetylneuraminic acid (Neu5Ac) into N-glycolylneuraminic acid (Neu5Gc), humans have an inactive CMAH, causing an absence of Neu5Gc and excess Neu5Ac.	N-Acetylneuraminic Acid	252-258	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	89-93
27551071-5	2016	The antibody-sialidase conjugate desialylated tumor cells in a HER2-dependent manner, reduced binding by natural killer (NK) cell inhibitory sialic acid-binding Ig-like lectin (Siglec) receptors, and enhanced binding to the NK-activating receptor natural killer group 2D (NKG2D).	N-Acetylneuraminic Acid	141-152	erb-b2 receptor tyrosine kinase 2	Homo sapiens	63-67
27448041-3	2016	This study examines influence of tobacco smoking on transferrin sialic acid residues and its connection to foetal nourishment at women with iron deficiency.	N-Acetylneuraminic Acid	64-75	transferrin	Homo sapiens	52-63
27755584-2	2016	Type A and type B antigens are Neu5Gc and Neu5Ac, respectively, and the enzyme CMAH participating in the synthesis of Neu5Gc from Neu5Ac is associated with this cat blood group system.	N-Acetylneuraminic Acid	130-136	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Felis catus	79-83
27755584-11	2016	These results suggested that double haploids selected from multiple recessive alleles in the cat CMAH loci were highly associated with the expression of the Neu5Ac on erythrocyte membrane in types B and AB of the feline AB blood group system.	N-Acetylneuraminic Acid	157-163	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Felis catus	97-101
27731409-4	2016	Second, we discovered that the focal uptake of VAP-1 targeting sialic acid-binding immunoglobulin-like lectin 9 based PET tracer [68Ga]DOTA-Siglec-9 in atherosclerotic plaques was associated with the density of activated macrophages (r = 0.58, P = 0.022).	N-Acetylneuraminic Acid	63-74	amine oxidase, copper containing 3	Mus musculus	47-52
27731409-4	2016	Second, we discovered that the focal uptake of VAP-1 targeting sialic acid-binding immunoglobulin-like lectin 9 based PET tracer [68Ga]DOTA-Siglec-9 in atherosclerotic plaques was associated with the density of activated macrophages (r = 0.58, P = 0.022).	N-Acetylneuraminic Acid	63-74	sialic acid binding Ig-like lectin E	Mus musculus	140-148
27018228-2	2016	By attaching sialic acid onto the terminal galactoses of biantennary protein N-glycans, ST6Gal-I facilitates protein remodeling towards a humanized glycosylation and thus optimized efficacy in pharmacological use.	N-Acetylneuraminic Acid	13-24	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	88-96
27711121-11	2016	We further found that T. forsythia adhered to human oral epithelial cells, which express E-selectin and P-selectin, and that this adhesion was inhibited by addition of NeuAc.	N-Acetylneuraminic Acid	168-173	selectin E	Homo sapiens	89-99
27711121-11	2016	We further found that T. forsythia adhered to human oral epithelial cells, which express E-selectin and P-selectin, and that this adhesion was inhibited by addition of NeuAc.	N-Acetylneuraminic Acid	168-173	selectin P	Homo sapiens	104-114
27343486-4	2016	The mechanism may involve the neuraminidase inhibition which decrease platelet surface sialic acid content and reduce their removal by the reticuloendothelial system.	N-Acetylneuraminic Acid	87-98	neuraminidase 1	Homo sapiens	30-43
27184018-1	2016	BACKGROUND AND OBJECTIVES: In mice, loss of sialic acid resulting in shedding of glycoprotein (GP) Ibalpha and GPV has been linked to platelet survival.	N-Acetylneuraminic Acid	44-55	glycoprotein 1b, alpha polypeptide	Mus musculus	81-106
27506346-7	2016	The results showed that Maackia amurensis agglutinin (MAA) recognizing alpha-2,3-terminal sialic acid can be applied to distinguish between these two sets of samples since the MAA/PSA response obtained from the analysis of the PCa samples was significantly higher (5.3-fold) compared to the MAA/PSA response obtained by the analysis of samples from healthy individuals.	N-Acetylneuraminic Acid	90-101	kallikrein related peptidase 3	Homo sapiens	295-298
27084258-2	2016	The biological activity of ESAs is mainly regulated by the number of sialic acid-containing carbohydrates on the erythropoietin (EPO) peptide.	N-Acetylneuraminic Acid	69-80	erythropoietin	Homo sapiens	113-127
27380425-3	2016	We show that transformation of mammary epithelial cells by oncogenic stimuli commonly shunts glucose-derived carbons into synthesis of sialic acid, a hexosamine pathway metabolite that is converted to CMP-sialic acid by cytidine monophosphate N-acetylneuraminic acid synthase (CMAS) as a precursor to glycoprotein and glycolipid sialylation.	N-Acetylneuraminic Acid	135-146	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	220-275
27380425-3	2016	We show that transformation of mammary epithelial cells by oncogenic stimuli commonly shunts glucose-derived carbons into synthesis of sialic acid, a hexosamine pathway metabolite that is converted to CMP-sialic acid by cytidine monophosphate N-acetylneuraminic acid synthase (CMAS) as a precursor to glycoprotein and glycolipid sialylation.	N-Acetylneuraminic Acid	135-146	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	277-281
27380425-3	2016	We show that transformation of mammary epithelial cells by oncogenic stimuli commonly shunts glucose-derived carbons into synthesis of sialic acid, a hexosamine pathway metabolite that is converted to CMP-sialic acid by cytidine monophosphate N-acetylneuraminic acid synthase (CMAS) as a precursor to glycoprotein and glycolipid sialylation.	N-Acetylneuraminic Acid	205-216	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	220-275
27380425-3	2016	We show that transformation of mammary epithelial cells by oncogenic stimuli commonly shunts glucose-derived carbons into synthesis of sialic acid, a hexosamine pathway metabolite that is converted to CMP-sialic acid by cytidine monophosphate N-acetylneuraminic acid synthase (CMAS) as a precursor to glycoprotein and glycolipid sialylation.	N-Acetylneuraminic Acid	205-216	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	277-281
27380425-4	2016	We show that CMAS knockdown leads to elevations in intracellular sialic acid levels, a depletion of cellular sialylation, and alterations in the expression of many cancer-relevant genes to impair breast cancer pathogenicity.	N-Acetylneuraminic Acid	65-76	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	13-17
27325697-4	2016	Thus, the removal of either an acyl chain or sialic acid from the GPI anchor reduced the targeting of PrP(C) to synapses.	N-Acetylneuraminic Acid	45-56	prion protein	Mus musculus	102-108
27487469-7	2016	CD169, a sialic acid-binding lectin, helps retain the cells within the sinus, preventing their loss in lymph flow.	N-Acetylneuraminic Acid	9-20	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	0-5
27084258-2	2016	The biological activity of ESAs is mainly regulated by the number of sialic acid-containing carbohydrates on the erythropoietin (EPO) peptide.	N-Acetylneuraminic Acid	69-80	erythropoietin	Homo sapiens	129-132
27357083-11	2016	Taken together, the results initially indicate that FXR1P interacts with CMAS, and that FXR1P may enhance the activation of sialic acid via interaction with CMAS, and increase GM1 levels to affect the development of the nervous system, thus providing evidence for further research into the pathogenesis of FXS.	N-Acetylneuraminic Acid	124-135	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	73-77
27357083-11	2016	Taken together, the results initially indicate that FXR1P interacts with CMAS, and that FXR1P may enhance the activation of sialic acid via interaction with CMAS, and increase GM1 levels to affect the development of the nervous system, thus providing evidence for further research into the pathogenesis of FXS.	N-Acetylneuraminic Acid	124-135	FMR1 autosomal homolog 1	Homo sapiens	88-93
27357083-11	2016	Taken together, the results initially indicate that FXR1P interacts with CMAS, and that FXR1P may enhance the activation of sialic acid via interaction with CMAS, and increase GM1 levels to affect the development of the nervous system, thus providing evidence for further research into the pathogenesis of FXS.	N-Acetylneuraminic Acid	124-135	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	157-161
27416066-7	2016	Here, we demonstrate that DENV NS1 disrupts the EGL on human pulmonary microvascular endothelial cells, inducing degradation of sialic acid and shedding of heparan sulfate proteoglycans.	N-Acetylneuraminic Acid	128-139	influenza virus NS1A binding protein	Homo sapiens	31-34
27114558-2	2016	CSAS produces the activated sugar donor, CMP-sialic acid, which serves as a substrate for sialyltransferases to modify glycan termini with sialic acid.	N-Acetylneuraminic Acid	45-56	CMP-sialic acid synthase	Drosophila melanogaster	0-4
27114558-2	2016	CSAS produces the activated sugar donor, CMP-sialic acid, which serves as a substrate for sialyltransferases to modify glycan termini with sialic acid.	N-Acetylneuraminic Acid	139-150	CMP-sialic acid synthase	Drosophila melanogaster	0-4
27114558-5	2016	DmCSAS displays specificity for N-acetylneuraminic acid as a substrate, shows preference for lower pH and can function with a broad range of metal cofactors.	N-Acetylneuraminic Acid	32-55	CMP-sialic acid synthase	Drosophila melanogaster	0-6
27129263-4	2016	We also found that the expression of Siglec-1 (a member of sialic acid-binding Ig (I)-like lectin family members, the predominant sialic acid-binding proteins on cell surface) was specifically up-regulated in endotoxin tolerant cells and the induction of Siglec-1 suppresses the innate immune response by promoting TGF-beta1 production.	N-Acetylneuraminic Acid	59-70	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	37-45
27213289-0	2016	NANS-mediated synthesis of sialic acid is required for brain and skeletal development.	N-Acetylneuraminic Acid	27-38	N-acetylneuraminate synthase	Homo sapiens	0-4
27213289-1	2016	We identified biallelic mutations in NANS, the gene encoding the synthase for N-acetylneuraminic acid (NeuNAc; sialic acid), in nine individuals with infantile-onset severe developmental delay and skeletal dysplasia.	N-Acetylneuraminic Acid	78-101	N-acetylneuraminate synthase	Homo sapiens	37-41
27213289-1	2016	We identified biallelic mutations in NANS, the gene encoding the synthase for N-acetylneuraminic acid (NeuNAc; sialic acid), in nine individuals with infantile-onset severe developmental delay and skeletal dysplasia.	N-Acetylneuraminic Acid	103-109	N-acetylneuraminate synthase	Homo sapiens	37-41
27213289-1	2016	We identified biallelic mutations in NANS, the gene encoding the synthase for N-acetylneuraminic acid (NeuNAc; sialic acid), in nine individuals with infantile-onset severe developmental delay and skeletal dysplasia.	N-Acetylneuraminic Acid	111-122	N-acetylneuraminate synthase	Homo sapiens	37-41
27213289-4	2016	Thus, NANS-mediated synthesis of sialic acid is required for early brain development and skeletal growth.	N-Acetylneuraminic Acid	33-44	N-acetylneuraminate synthase	Homo sapiens	6-10
27419199-1	2016	The data presented in this article describe an effect of N-acetylneuraminic acid and/or quercetin on the inflammatory proteins expressions (TNF-alpha, ICAM-1, VCAM-1 and MOMA-2) and the N-acetylneuraminic acid (NANA) levels of apolipoprotein E-deficient mice that are given a high-fat diet.	N-Acetylneuraminic Acid	57-80	tumor necrosis factor	Mus musculus	140-149
27419199-1	2016	The data presented in this article describe an effect of N-acetylneuraminic acid and/or quercetin on the inflammatory proteins expressions (TNF-alpha, ICAM-1, VCAM-1 and MOMA-2) and the N-acetylneuraminic acid (NANA) levels of apolipoprotein E-deficient mice that are given a high-fat diet.	N-Acetylneuraminic Acid	57-80	intercellular adhesion molecule 1	Mus musculus	151-157
27419199-1	2016	The data presented in this article describe an effect of N-acetylneuraminic acid and/or quercetin on the inflammatory proteins expressions (TNF-alpha, ICAM-1, VCAM-1 and MOMA-2) and the N-acetylneuraminic acid (NANA) levels of apolipoprotein E-deficient mice that are given a high-fat diet.	N-Acetylneuraminic Acid	57-80	vascular cell adhesion molecule 1	Mus musculus	159-165
27333049-6	2016	Sialic acid-independent strains, that presumably are able to bind to CR1 via a native ligand, showed less complement-dependent enhancement of RBC invasion than sialic acid-dependent strains that do not utilize native CR1 ligands.	N-Acetylneuraminic Acid	0-11	complement receptor 2	Mus musculus	69-72
27333049-6	2016	Sialic acid-independent strains, that presumably are able to bind to CR1 via a native ligand, showed less complement-dependent enhancement of RBC invasion than sialic acid-dependent strains that do not utilize native CR1 ligands.	N-Acetylneuraminic Acid	0-11	complement receptor 2	Mus musculus	217-220
27333049-6	2016	Sialic acid-independent strains, that presumably are able to bind to CR1 via a native ligand, showed less complement-dependent enhancement of RBC invasion than sialic acid-dependent strains that do not utilize native CR1 ligands.	N-Acetylneuraminic Acid	160-171	complement receptor 2	Mus musculus	69-72
27345319-6	2016	Gene expression profiling of equine preimplantation conceptuses revealed expression of neuraminidase 2 (NEU2), an enzyme that cleaves sialic acid from polysaccharide chains.	N-Acetylneuraminic Acid	134-145	neuraminidase 2	Equus caballus	87-102
27345319-6	2016	Gene expression profiling of equine preimplantation conceptuses revealed expression of neuraminidase 2 (NEU2), an enzyme that cleaves sialic acid from polysaccharide chains.	N-Acetylneuraminic Acid	134-145	neuraminidase 2	Equus caballus	104-108
27345319-7	2016	Furthermore, secretion of NEU2 by conceptuses in vitro was functionally active; it appears therefore, that the conceptus itself regulates sialic acid content through expression of NEU2.	N-Acetylneuraminic Acid	138-149	neuraminidase 2	Equus caballus	26-30
27303031-4	2016	We also discovered that secreted ST6Gal1 is produced by cells lining central veins in the liver and that IgG sialylation is powered by serum-localized nucleotide sugar donor CMP-sialic acid that is at least partially derived from degranulating platelets.	N-Acetylneuraminic Acid	178-189	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	33-40
27606346-0	2016	Neurologic syndrome associated with homozygous mutation at MAG sialic acid binding site.	N-Acetylneuraminic Acid	63-74	myelin associated glycoprotein	Homo sapiens	59-62
27006390-6	2016	In this article, we show that, instead of disturbed heparin interactions, the impaired ability of C-terminal mutant FH molecules to recognize sialic acid in the context of surface-bound C3b explains their pathogenicity.	N-Acetylneuraminic Acid	142-153	complement C3	Homo sapiens	186-189
27006390-11	2016	Proper formation of FH-sialic acid-C3b complexes on surfaces exposed to plasma is essential for preventing cell damage and thrombogenesis characteristic of aHUS.	N-Acetylneuraminic Acid	23-34	complement C3	Homo sapiens	35-38
27129263-4	2016	We also found that the expression of Siglec-1 (a member of sialic acid-binding Ig (I)-like lectin family members, the predominant sialic acid-binding proteins on cell surface) was specifically up-regulated in endotoxin tolerant cells and the induction of Siglec-1 suppresses the innate immune response by promoting TGF-beta1 production.	N-Acetylneuraminic Acid	59-70	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	255-263
27129263-4	2016	We also found that the expression of Siglec-1 (a member of sialic acid-binding Ig (I)-like lectin family members, the predominant sialic acid-binding proteins on cell surface) was specifically up-regulated in endotoxin tolerant cells and the induction of Siglec-1 suppresses the innate immune response by promoting TGF-beta1 production.	N-Acetylneuraminic Acid	59-70	transforming growth factor, beta 1	Mus musculus	315-324
27129263-4	2016	We also found that the expression of Siglec-1 (a member of sialic acid-binding Ig (I)-like lectin family members, the predominant sialic acid-binding proteins on cell surface) was specifically up-regulated in endotoxin tolerant cells and the induction of Siglec-1 suppresses the innate immune response by promoting TGF-beta1 production.	N-Acetylneuraminic Acid	130-141	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	37-45
27172906-1	2016	A sialic acid-binding lectin (SRC) was created from the C-terminal domain of an R-type N-acetyl lactosamine-binding lectin (EW29Ch) by natural evolution-mimicry.	N-Acetylneuraminic Acid	2-13	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	30-33
26945091-1	2016	The apoC-III proteoform containing two sialic acid residues (apoC-III2) has different in vitro effects on lipid metabolism compared with asialylated (apoC-III0) or the most abundant monosialylated (apoC-III1) proteoforms.	N-Acetylneuraminic Acid	39-50	apolipoprotein C3	Homo sapiens	4-12
27406771-7	2016	Supplementation of ManNAc, a precursor of sialic acid, significantly reduces albuminuria in those rats by increasing sialylation of the hyposialylated form of Angptl4.	N-Acetylneuraminic Acid	42-53	angiopoietin-like 4	Rattus norvegicus	159-166
26993524-2	2016	Previous studies suggest a pathophysiological role for neuraminidase 1 (NEU1), an enzyme that removes terminal sialic acid from glycoproteins.	N-Acetylneuraminic Acid	111-122	neuraminidase 1	Homo sapiens	55-70
26993524-2	2016	Previous studies suggest a pathophysiological role for neuraminidase 1 (NEU1), an enzyme that removes terminal sialic acid from glycoproteins.	N-Acetylneuraminic Acid	111-122	neuraminidase 1	Homo sapiens	72-76
26148146-5	2016	Additionally, the levels of sialic acid and carnitine were lower in the experimental group than that in either the sham or the control group (P &lt; 0.05) and were significantly negatively correlated with HIF-1alpha expression (r = -0.620, P = 0.014, and r = -0.610, P = 0.016 respectively).	N-Acetylneuraminic Acid	28-39	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	205-215
27041489-3	2016	While macaques synthesize the sialic acid variant N-glycolylneuraminic acid (Neu5Gc), humans cannot because of a mutation in the enzyme CMAH that converts N-acetylneuraminic acid (Neu5Ac) to Neu5Gc.	N-Acetylneuraminic Acid	155-178	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	136-140
27041489-3	2016	While macaques synthesize the sialic acid variant N-glycolylneuraminic acid (Neu5Gc), humans cannot because of a mutation in the enzyme CMAH that converts N-acetylneuraminic acid (Neu5Ac) to Neu5Gc.	N-Acetylneuraminic Acid	180-186	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	136-140
27065798-0	2016	Sialic Acid Is Required for Neuronal Inhibition by Soluble MAG but not for Membrane Bound MAG.	N-Acetylneuraminic Acid	0-11	myelin associated glycoprotein	Homo sapiens	59-62
27065798-2	2016	Importantly, MAG (also known as Siglec-4) is a member of the Siglec family of proteins (sialic acid-binding, immunoglobulin-like lectins), MAG binds to complex gangliosides, specifically GD1a and/or GT1b.	N-Acetylneuraminic Acid	88-99	myelin associated glycoprotein	Homo sapiens	13-16
27065798-4	2016	Previously, we showed that MAG binds sialic acid through domain 1 at Arg118 and is able to inhibit axonal growth through domain 5.	N-Acetylneuraminic Acid	37-48	myelin associated glycoprotein	Homo sapiens	27-30
27065798-10	2016	Also, we propose a model in which the sialic acid binding is not necessary for the inhibition induced by the membrane form of MAG, but it is necessary for the soluble form of MAG.	N-Acetylneuraminic Acid	38-49	myelin associated glycoprotein	Homo sapiens	175-178
27011118-7	2016	R54high leukemia cells, which are likely to express sialic acid-rich CD43, were highly resistant to CTL-mediated cytolysis.	N-Acetylneuraminic Acid	52-63	sialophorin	Mus musculus	69-73
27011118-9	2016	These results suggest that sialic acid-rich CD43, which harbors multiple sialic acid residues that impart a net negative surface charge, protects leukemia cells from CTL-mediated cell lysis.	N-Acetylneuraminic Acid	27-38	sialophorin	Mus musculus	44-48
27011118-9	2016	These results suggest that sialic acid-rich CD43, which harbors multiple sialic acid residues that impart a net negative surface charge, protects leukemia cells from CTL-mediated cell lysis.	N-Acetylneuraminic Acid	73-84	sialophorin	Mus musculus	44-48
26885857-5	2016	This effect was mediated by the disruption of CD45 protein dimerization regulated by sialic acid.	N-Acetylneuraminic Acid	85-96	protein tyrosine phosphatase receptor type C	Homo sapiens	46-50
26836849-5	2016	This protocol has been used to in situ quantify EpCAM-specific sialic acid on MCF-7 cell surface and monitor its variation during drug treatment.	N-Acetylneuraminic Acid	63-74	epithelial cell adhesion molecule	Homo sapiens	48-53
26749288-13	2016	Subsequent experiments revealed that the promotion was dependent on platelet-surface glycoproteins, as removal of sialic acid from platelet glycoproteins by neuraminidase abolished the enhancement.	N-Acetylneuraminic Acid	114-125	neuraminidase 1	Homo sapiens	157-170
26968811-2	2016	It is caused by a mutation in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene, which encodes a key enzyme in sialic acid biosynthesis.	N-Acetylneuraminic Acid	139-150	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	98-101
26980148-1	2016	The bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) plays a key role in sialic acid production.	N-Acetylneuraminic Acid	87-98	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	62-65
26980148-3	2016	Here the complex crystal structure of the N-terminal epimerase part of human GNE shows a tetramer in which UDP binds to the active site and CMP-Neu5Ac binds to the dimer-dimer interface.	N-Acetylneuraminic Acid	144-150	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	77-80
26919106-3	2016	Furthermore, the recognition by NKp46 and consequent elimination of influenza infected cells were determined to be sialic-acid dependent.	N-Acetylneuraminic Acid	115-126	natural cytotoxicity triggering receptor 1	Homo sapiens	32-37
27854209-0	2016	Aceneuramic Acid Extended Release Administration Maintains Upper Limb Muscle Strength in a 48-week Study of Subjects with GNE Myopathy: Results from a Phase 2, Randomized, Controlled Study.	N-Acetylneuraminic Acid	0-16	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	122-125
27854209-1	2016	BACKGROUND: GNE Myopathy (GNEM) is a progressive adult-onset myopathy likely caused by deficiency of sialic acid (SA) biosynthesis.	N-Acetylneuraminic Acid	114-116	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	12-15
26684016-8	2016	This shows that sialic acid residues present on CD172a+ cells are essential in the initiation of EHV-1 infection.	N-Acetylneuraminic Acid	16-27	signal regulatory protein alpha	Homo sapiens	48-54
26700765-6	2016	Mechanistically, we found that miR-27a directly targeted sialic acid-binding Ig-like lectin (Siglec)1 and E3 ubiquitin ligase tripartite motif-containing protein 27 (TRIM27), both of which were previously verified as negative regulators of type I IFN production.	N-Acetylneuraminic Acid	57-68	microRNA 27a	Mus musculus	31-38
26851523-0	2016	Sialic acid-specific affinity chromatography for the separation of erythropoietin glycoforms using serotonin as a ligand.	N-Acetylneuraminic Acid	0-11	erythropoietin	Homo sapiens	67-81
26727964-5	2016	Sialin, a lysosomal protein, is shown to be crucial for the export of exogenous sialic acid from lysosomes to the cytosol.	N-Acetylneuraminic Acid	80-91	solute carrier family 17 member 5	Homo sapiens	0-6
26714302-3	2016	The interaction of MPO with RBC proteins was mostly electrostatic in nature because it was inhibited by desialation, exogenic sialic acid, high ionic strength, and extreme pH.	N-Acetylneuraminic Acid	126-137	myeloperoxidase	Homo sapiens	19-22
25966635-2	2016	It is caused by variants in the GNE gene that encodes a key bifunctional enzyme in the sialic acid biosynthetic pathway.	N-Acetylneuraminic Acid	87-98	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	32-35
26700765-6	2016	Mechanistically, we found that miR-27a directly targeted sialic acid-binding Ig-like lectin (Siglec)1 and E3 ubiquitin ligase tripartite motif-containing protein 27 (TRIM27), both of which were previously verified as negative regulators of type I IFN production.	N-Acetylneuraminic Acid	57-68	tripartite motif-containing 27	Mus musculus	166-172
26553874-4	2016	In contrast, PrP(C) containing a GPI anchor from which the sialic acid had been removed (desialylated PrP(C)) was not converted to PrP(Sc).	N-Acetylneuraminic Acid	59-70	prion protein	Mus musculus	13-19
27468569-0	2016	Serum Sialic Acid Concentration and Content in ApoB-Containing Lipoproteins in Liver Diseases.	N-Acetylneuraminic Acid	6-17	apolipoprotein B	Homo sapiens	47-51
27468569-2	2016	In VILDL and LDL sialic acid is attached to apolipoprotein B.	N-Acetylneuraminic Acid	17-28	apolipoprotein B	Homo sapiens	44-60
27468569-4	2016	Therefore, the aim of this study was to assess the effect of liver diseases on the concentration and content of SA in ApoB-containing lipoproteins.	N-Acetylneuraminic Acid	112-114	apolipoprotein B	Homo sapiens	118-122
27468569-6	2016	ApoB-containing lipoproteins were isolated by a turbidimetric procedure and SA concentration was measured according to an enzymatic method.	N-Acetylneuraminic Acid	76-78	apolipoprotein B	Homo sapiens	0-4
27468569-7	2016	RESULTS: There was a significant increase in the serum concentration of SA in ApoB-containing lipoproteins in viral hepatitis.	N-Acetylneuraminic Acid	72-74	apolipoprotein B	Homo sapiens	78-82
27468569-8	2016	Although the serum concentration of ApoB was not significantly different between specific liver diseases, the serum levels of SA in ApoB-containing lipoproteins appeared to be different.	N-Acetylneuraminic Acid	126-128	apolipoprotein B	Homo sapiens	132-136
27468569-11	2016	The content of SA in ApoB-containing lipoproteins in alcoholic cirrhosis and viral hepatitis was significantly higher than that in the control group, but did not differ between diseases.	N-Acetylneuraminic Acid	15-17	apolipoprotein B	Homo sapiens	21-25
27468569-13	2016	It seems that the reason for these abnormalities is the changes in the concentration of sialic acid in ApoB-containing lipoproteins.	N-Acetylneuraminic Acid	88-99	apolipoprotein B	Homo sapiens	103-107
26411873-3	2016	We unexpectedly discovered that hSiglec-9 also specifically binds high molecular weight hyaluronan (HMW-HA), another ubiquitous host glycan, through a region of its terminal Ig-like V-set domain distinct from the Sia-binding site.	N-Acetylneuraminic Acid	213-216	sialic acid binding Ig like lectin 9	Homo sapiens	32-41
26411873-7	2016	KEY MESSAGE: HMW-HA is the first example of a non-sialic acid containing glycan to be recognized by CD33-related Siglecs.	N-Acetylneuraminic Acid	50-61	CD33 molecule	Homo sapiens	100-104
26553874-9	2016	These findings show that the sialic acid moiety of the GPI attached to PrP(C) modifies local membrane microenvironments that are important in PrP-mediated cell signaling and PrP(Sc) formation.	N-Acetylneuraminic Acid	29-40	prion protein	Mus musculus	71-77
27063181-4	2016	With synthetic substrates it was shown that sialic acid O-acetylation at C-4 hinders the activity of sialidases, with the exception of viral enzymes.	N-Acetylneuraminic Acid	44-55	complement C4A (Rodgers blood group)	Homo sapiens	73-76
26335155-5	2016	We show mass spectrometric data combined with data from enzymatic digestions that suggest the presence of a tetrasaccharide consisting of two N-acetylglucosamines, one galactose, and one sialic acid, appearing on serum TF, is a biomarker of this particular CDG subtype.	N-Acetylneuraminic Acid	187-198	transferrin	Homo sapiens	219-221
27160740-0	2016	Pretreatment of Sialic Acid Efficiently Prevents Lipopolysaccharide-Induced Acute Renal Failure and Suppresses TLR4/gp91-Mediated Apoptotic Signaling.	N-Acetylneuraminic Acid	16-27	toll-like receptor 4	Rattus norvegicus	111-115
27160740-8	2016	Furthermore, SA pretreatment significantly depressed TLR4 activation, gp91 expression, and Caspase 3/PARP induced apoptosis in the kidneys.	N-Acetylneuraminic Acid	13-15	toll-like receptor 4	Rattus norvegicus	53-57
27160740-8	2016	Furthermore, SA pretreatment significantly depressed TLR4 activation, gp91 expression, and Caspase 3/PARP induced apoptosis in the kidneys.	N-Acetylneuraminic Acid	13-15	caspase 3	Rattus norvegicus	91-100
27160740-9	2016	CONCLUSION: We suggest that pretreatment of SA significantly and preventively attenuated LPS-induced detrimental effects on systemic and renal hemodynamics, renal ROS production and renal function, as well as, LPS-activated TLR4/gp91/Caspase3 mediated apoptosis signaling.	N-Acetylneuraminic Acid	44-46	toll-like receptor 4	Rattus norvegicus	224-228
27160740-9	2016	CONCLUSION: We suggest that pretreatment of SA significantly and preventively attenuated LPS-induced detrimental effects on systemic and renal hemodynamics, renal ROS production and renal function, as well as, LPS-activated TLR4/gp91/Caspase3 mediated apoptosis signaling.	N-Acetylneuraminic Acid	44-46	caspase 3	Rattus norvegicus	234-242
26378150-0	2015	Characterization of a sialate-O-acetylesterase (NanS) from the oral pathogen Tannerella forsythia that enhances sialic acid release by NanH, its cognate sialidase.	N-Acetylneuraminic Acid	112-123	sialic acid acetylesterase	Homo sapiens	22-46
26507663-1	2015	CD22 is an inhibitory B-cell co-receptor whose function is modulated by sialic acid (Sia)-bearing glycan ligands.	N-Acetylneuraminic Acid	72-83	CD22 molecule	Homo sapiens	0-4
26507663-1	2015	CD22 is an inhibitory B-cell co-receptor whose function is modulated by sialic acid (Sia)-bearing glycan ligands.	N-Acetylneuraminic Acid	85-88	CD22 molecule	Homo sapiens	0-4
26507663-9	2015	Instead, the high affinity ligand for mouse CD22 has N-glycolylneuraminic acid (Neu5Gc) as the sialic acid, which is replaced on GC B-cells with Neu5Ac.	N-Acetylneuraminic Acid	95-106	CD22 antigen	Mus musculus	44-48
26507663-9	2015	Instead, the high affinity ligand for mouse CD22 has N-glycolylneuraminic acid (Neu5Gc) as the sialic acid, which is replaced on GC B-cells with Neu5Ac.	N-Acetylneuraminic Acid	145-151	CD22 antigen	Mus musculus	44-48
26507663-9	2015	Instead, the high affinity ligand for mouse CD22 has N-glycolylneuraminic acid (Neu5Gc) as the sialic acid, which is replaced on GC B-cells with Neu5Ac.	N-Acetylneuraminic Acid	145-151	natriuretic peptide receptor 2	Mus musculus	129-133
26507663-11	2015	In mice, Neu5Gc-containing glycans serve as high affinity CD22 ligands that are replaced by Neu5Ac-containing glycans on GC B-cells.	N-Acetylneuraminic Acid	92-98	natriuretic peptide receptor 2	Mus musculus	121-125
26194636-1	2015	B cell antigen receptor signaling on B-1 cells is controlled by several inhibitory receptors, including Siglec-G, which is a member of the Siglec (sialic acid-binding immunoglobulin-like lectin) family and inhibits B cell signaling.	N-Acetylneuraminic Acid	147-158	sialic acid binding Ig-like lectin G	Mus musculus	104-112
26194636-4	2015	Mouse models have provided evidence that Siglec-G binds to the B cell receptor (BCR) on the B cell surface via interaction with sialic acid ligands.	N-Acetylneuraminic Acid	128-139	sialic acid binding Ig-like lectin G	Mus musculus	41-49
26378150-0	2015	Characterization of a sialate-O-acetylesterase (NanS) from the oral pathogen Tannerella forsythia that enhances sialic acid release by NanH, its cognate sialidase.	N-Acetylneuraminic Acid	112-123	N-acetylneuraminate synthase	Bos taurus	48-52
26378150-10	2015	When incubated with its cognate sialidase, NanS increased sialic acid release from mucin and oral epithelial cell surfaces, implying that this esterase improves sialic acid harvesting for this pathogen and potentially other members of the oral microbiome.	N-Acetylneuraminic Acid	58-69	N-acetylneuraminate synthase	Bos taurus	43-47
26378150-10	2015	When incubated with its cognate sialidase, NanS increased sialic acid release from mucin and oral epithelial cell surfaces, implying that this esterase improves sialic acid harvesting for this pathogen and potentially other members of the oral microbiome.	N-Acetylneuraminic Acid	58-69	mucin 1, cell surface associated	Bos taurus	83-88
26378150-10	2015	When incubated with its cognate sialidase, NanS increased sialic acid release from mucin and oral epithelial cell surfaces, implying that this esterase improves sialic acid harvesting for this pathogen and potentially other members of the oral microbiome.	N-Acetylneuraminic Acid	161-172	N-acetylneuraminate synthase	Bos taurus	43-47
26378150-10	2015	When incubated with its cognate sialidase, NanS increased sialic acid release from mucin and oral epithelial cell surfaces, implying that this esterase improves sialic acid harvesting for this pathogen and potentially other members of the oral microbiome.	N-Acetylneuraminic Acid	161-172	mucin 1, cell surface associated	Bos taurus	83-88
26378150-11	2015	In summary, we have characterized a novel sialate-O-acetylesterase that contributes to the sialobiology of this important human pathogen and has potential applications in the analysis of sialic acid diacetylation of biologics in the pharmaceutical industry.	N-Acetylneuraminic Acid	187-198	sialic acid acetylesterase	Homo sapiens	42-66
26497328-6	2015	We also showed that H-ALCL cell adhesion to galectin-3 was enhanced by pre-treatment with neuraminidase, which cleaves cell surface sialic acid.	N-Acetylneuraminic Acid	132-143	neuraminidase 1	Homo sapiens	90-103
26206501-1	2015	An elevated level of the free deaminated sialic acid, 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), was first discovered in human ovarian cancers (OCs), suggesting that KDN may be an oncodevelopmental antigen (Inoue S, Lin SL, Chang T, Wu SH, Yao CW, Chu TY, Troy FA II, Inoue Y.	N-Acetylneuraminic Acid	41-52	TNF receptor superfamily member 19	Homo sapiens	268-272
26459514-9	2015	Our results demonstrate that an endogenous non-sialic acid-bearing molecule can be either a danger-associated or self-associated signal through paired Siglecs, and may explain seemingly contradictory prior reports on extracellular Hsp70 action.	N-Acetylneuraminic Acid	47-58	heat shock protein family A (Hsp70) member 4	Homo sapiens	231-236
26087043-3	2015	TREM2, by transmitting signals via the immunoreceptor tyrosine-based activation motif (ITAM) of DAP12, stimulates phagocytic activity of microglia, and ITAM signaling is counterbalanced by sialic acid-binding immunoglobulin (Ig)-like lectins (Siglecs)-mediated immunoreceptor tyrosine-based inhibitory motif (ITIM) signaling.	N-Acetylneuraminic Acid	189-200	triggering receptor expressed on myeloid cells 2	Homo sapiens	0-5
26087043-3	2015	TREM2, by transmitting signals via the immunoreceptor tyrosine-based activation motif (ITAM) of DAP12, stimulates phagocytic activity of microglia, and ITAM signaling is counterbalanced by sialic acid-binding immunoglobulin (Ig)-like lectins (Siglecs)-mediated immunoreceptor tyrosine-based inhibitory motif (ITIM) signaling.	N-Acetylneuraminic Acid	189-200	transmembrane immune signaling adaptor TYROBP	Homo sapiens	96-101
26606595-0	2015	The Sialic Acid Binding Protein, Hsa, in Streptococcus gordonii DL1 also Mediates Intergeneric Coaggregation with Veillonella Species.	N-Acetylneuraminic Acid	4-15	albumin	Homo sapiens	33-36
26606595-6	2015	Interestingly, the same domains shown to be required for Hsa binding to sialic acid on the human cell surface are also required for coaggregation with Veillonella sp.	N-Acetylneuraminic Acid	72-83	albumin	Homo sapiens	57-60
26497328-6	2015	We also showed that H-ALCL cell adhesion to galectin-3 was enhanced by pre-treatment with neuraminidase, which cleaves cell surface sialic acid.	N-Acetylneuraminic Acid	132-143	galectin 3	Homo sapiens	44-54
26627256-8	2015	General inhibitors of sialyltranserases (STs), the enzymes that transfer sialic acid residues onto terminal positions of glycans, suppressed extrasialylation of PrP(Sc).	N-Acetylneuraminic Acid	73-84	prion protein	Mus musculus	161-164
26370074-0	2015	Mouse Siglec-1 Mediates trans-Infection of Surface-bound Murine Leukemia Virus in a Sialic Acid N-Acyl Side Chain-dependent Manner.	N-Acetylneuraminic Acid	84-95	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	6-14
26552809-2	2015	Sialyltransferase ST3GAL-1, which adds a sialic acid in an alpha-2,3 linkage to Gal beta1,3 GalNAc, preforms an important role in modulating cellular behaviors.	N-Acetylneuraminic Acid	41-52	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	18-26
26552809-2	2015	Sialyltransferase ST3GAL-1, which adds a sialic acid in an alpha-2,3 linkage to Gal beta1,3 GalNAc, preforms an important role in modulating cellular behaviors.	N-Acetylneuraminic Acid	41-52	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	84-91
26370074-1	2015	Siglec-1 (sialoadhesin, CD169) is a surface receptor on human cells that mediates trans-enhancement of HIV-1 infection through recognition of sialic acid moieties in virus membrane gangliosides.	N-Acetylneuraminic Acid	142-153	sialic acid binding Ig like lectin 1	Homo sapiens	10-22
26370074-1	2015	Siglec-1 (sialoadhesin, CD169) is a surface receptor on human cells that mediates trans-enhancement of HIV-1 infection through recognition of sialic acid moieties in virus membrane gangliosides.	N-Acetylneuraminic Acid	142-153	sialic acid binding Ig like lectin 1	Homo sapiens	24-29
26370074-1	2015	Siglec-1 (sialoadhesin, CD169) is a surface receptor on human cells that mediates trans-enhancement of HIV-1 infection through recognition of sialic acid moieties in virus membrane gangliosides.	N-Acetylneuraminic Acid	142-153	sialic acid binding Ig like lectin 1	Homo sapiens	0-8
26370074-9	2015	Thus, Siglec-1 is a key receptor for macrophage/lymphocyte trans-infection of surface-bound virions, and the N-acyl side chain of sialic acid is a critical determinant for the Siglec-1/MLV interaction.	N-Acetylneuraminic Acid	130-141	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	176-184
26436649-5	2015	In contrast, the presence of sialic acid abrogated the increased binding of C1q to Fc-galactosylated IgG1 and resulted in decreased levels of C3b deposition on the cell surface.	N-Acetylneuraminic Acid	29-40	complement C1q A chain	Homo sapiens	76-79
26530096-2	2015	We have recently discovered that sialic acid- binding immunoglobulin-like lectin 9 (Siglec-9) is a leukocyte ligand of VAP-1 and that 68Ga-labeled Siglec-9 motif peptide facilitates in vivo imaging of inflammation.	N-Acetylneuraminic Acid	33-44	sialic acid binding Ig like lectin 9	Homo sapiens	84-92
26530096-2	2015	We have recently discovered that sialic acid- binding immunoglobulin-like lectin 9 (Siglec-9) is a leukocyte ligand of VAP-1 and that 68Ga-labeled Siglec-9 motif peptide facilitates in vivo imaging of inflammation.	N-Acetylneuraminic Acid	33-44	amine oxidase copper containing 3	Homo sapiens	119-124
26530096-2	2015	We have recently discovered that sialic acid- binding immunoglobulin-like lectin 9 (Siglec-9) is a leukocyte ligand of VAP-1 and that 68Ga-labeled Siglec-9 motif peptide facilitates in vivo imaging of inflammation.	N-Acetylneuraminic Acid	33-44	sialic acid binding Ig like lectin 9	Homo sapiens	147-155
26436649-5	2015	In contrast, the presence of sialic acid abrogated the increased binding of C1q to Fc-galactosylated IgG1 and resulted in decreased levels of C3b deposition on the cell surface.	N-Acetylneuraminic Acid	29-40	endogenous retrovirus group K member 3	Homo sapiens	142-145
26436649-6	2015	Similar to monoclonal antibodies, sialic acid inhibited the increased C1q binding to galactosylated Fc fragments in human polyclonal IgG.	N-Acetylneuraminic Acid	34-45	complement C1q A chain	Homo sapiens	70-73
25838264-1	2015	BACKGROUND: Plasmodium falciparum invades human erythrocytes by using an array of ligands that interact with several receptors, including sialic acid (SA), complement receptor 1 (CR1), and basigin.	N-Acetylneuraminic Acid	151-153	basigin (Ok blood group)	Homo sapiens	189-196
26362733-3	2015	Histochemical and immunoelectron microscopic characterizations showed that the 5D4-reactive KS is expressed in Mac2/galectin-3-positive activated or proliferating microglia of SOD1(G93A) ALS model mice at disease end stage and that the KS is an O-linked glycan modified with sialic acid and fucose, which was thus far shown to exist in cartilage.	N-Acetylneuraminic Acid	275-286	lectin, galactose binding, soluble 3	Mus musculus	111-115
26154505-3	2015	Sialylation increased on both EPO and CHO cellular proteins as observed by SNA lectin analysis, and HPLC profiling revealed that the sialic acid content of total glycans on EPO increased by 26%.	N-Acetylneuraminic Acid	133-144	erythropoietin	Cricetulus griseus	173-176
26154505-7	2015	Furthermore, sialic acid content of rEPO from these engineered cells was increased ~45% higher with tetra-sialylation accounting for ~10% of total sugar chains compared to ~3% for the wild-type parental CHO-K1.	N-Acetylneuraminic Acid	13-24	erythropoietin	Rattus norvegicus	36-40
26258433-6	2015	Furthermore, Ac5NeuNPoc-based sialic acid glycoengineering enabled the on-cell synthesis of high-affinity Siglec-7 ligands and the identification of a novel Siglec-2 ligand.	N-Acetylneuraminic Acid	30-41	sialic acid binding Ig like lectin 7	Homo sapiens	106-114
26258433-6	2015	Furthermore, Ac5NeuNPoc-based sialic acid glycoengineering enabled the on-cell synthesis of high-affinity Siglec-7 ligands and the identification of a novel Siglec-2 ligand.	N-Acetylneuraminic Acid	30-41	CD22 molecule	Homo sapiens	157-165
26295436-7	2015	Finally, the impact of sialic acid supplementation on specific markers implicated in cancer progression was demonstrated by measuring levels of expression and sialylation of EGFR1 and MUC1 as well as the corresponding function of sialic acid-supplemented cells in migration assays.	N-Acetylneuraminic Acid	23-34	mucin 1, cell surface associated	Homo sapiens	184-188
25838264-8	2015	CR1 was a major mediator of SA-independent invasion, while basigin was essential for both SA-dependent and SA-independent invasion mechanisms.	N-Acetylneuraminic Acid	28-30	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	0-3
25838264-8	2015	CR1 was a major mediator of SA-independent invasion, while basigin was essential for both SA-dependent and SA-independent invasion mechanisms.	N-Acetylneuraminic Acid	90-92	basigin (Ok blood group)	Homo sapiens	59-66
25838264-8	2015	CR1 was a major mediator of SA-independent invasion, while basigin was essential for both SA-dependent and SA-independent invasion mechanisms.	N-Acetylneuraminic Acid	90-92	basigin (Ok blood group)	Homo sapiens	59-66
26492618-9	2015	Antibody-overlay lectin microarray using LpMab-9 demonstrated that PDPN reacts with sialic acid +- core1 binders and sialo-mucin binders.	N-Acetylneuraminic Acid	84-95	podoplanin	Homo sapiens	67-71
26629491-3	2015	The impact of sialic acid supplementation under nutrient deprivation was demonstrated by measuring levels of expression and sialylation of two markers, EGFR1 and MUC1.	N-Acetylneuraminic Acid	14-25	mucin 1, cell surface associated	Homo sapiens	162-166
26397189-2	2015	Herein, the synthesis of several dephosphonated CMP-Neu5Ac congeners and their anti-GM3-synthase activity is reported.	N-Acetylneuraminic Acid	52-58	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	84-96
26163659-1	2015	Polysialic acid (polySia) is a linear polymer of sialic acid that modifies neural cell adhesion molecule (NCAM) in the vertebrate brain.	N-Acetylneuraminic Acid	4-15	neural cell adhesion molecule 1	Homo sapiens	75-104
26163659-1	2015	Polysialic acid (polySia) is a linear polymer of sialic acid that modifies neural cell adhesion molecule (NCAM) in the vertebrate brain.	N-Acetylneuraminic Acid	4-15	neural cell adhesion molecule 1	Homo sapiens	106-110
29124209-1	2015	Human cytosolic sialidase (Neuraminidase 2, NEU2) catalyzes the removal of terminal sialic acid residues from glycoconjugates.	N-Acetylneuraminic Acid	84-95	neuraminidase 2	Homo sapiens	6-25
26177744-6	2015	The new method is exemplified by the analysis of the impact of inactivating mutations of the TGF-ss-receptor type II (TGFBR2) on sialic acid incorporation into protein-linked glycans of the colon cancer cell line HCT116.	N-Acetylneuraminic Acid	129-140	transforming growth factor beta receptor 2	Homo sapiens	118-124
26177744-7	2015	Overall, 70 proteins were found to show de novo sialic acid incorporation exclusively upon TGFBR2 expression whereas 7 proteins lost sialylation upon TGFBR2 reconstitution.	N-Acetylneuraminic Acid	48-59	transforming growth factor beta receptor 2	Homo sapiens	91-97
29124209-1	2015	Human cytosolic sialidase (Neuraminidase 2, NEU2) catalyzes the removal of terminal sialic acid residues from glycoconjugates.	N-Acetylneuraminic Acid	84-95	neuraminidase 2	Homo sapiens	27-42
29124209-1	2015	Human cytosolic sialidase (Neuraminidase 2, NEU2) catalyzes the removal of terminal sialic acid residues from glycoconjugates.	N-Acetylneuraminic Acid	84-95	neuraminidase 2	Homo sapiens	44-48
26329152-3	2015	The disease is caused by a mutation in the GNE gene that catalyzes two rate-limiting reactions in cytosolic sialic acid synthesis.	N-Acetylneuraminic Acid	108-119	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	43-46
26329152-4	2015	Oral treatment with sialic acid metabolite prevents muscle atrophy and weakness in a mouse GNE myopathy model and a global Phase III study is currently underway.	N-Acetylneuraminic Acid	20-31	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	91-94
25987743-1	2015	Siglec-G, a member of the sialic acid-binding Ig-like lectin (Siglec) family, is expressed on B cell and dendritic cell surfaces.	N-Acetylneuraminic Acid	26-37	sialic acid binding Ig-like lectin G	Mus musculus	0-8
26022181-1	2015	The plasma membrane-associated enzyme NEU3 sialidase functions to cleave sialic acid residues from the ganglioside GM3 thereby promoting its degradation, and has been implicated in the modulation of insulin action.	N-Acetylneuraminic Acid	73-84	neuraminidase 3	Rattus norvegicus	38-42
26022516-1	2015	Sialic acid acetyl esterase (SIAE) removes acetyl moieties from the hydroxyl groups in position 9 and 4 of sialic acid.	N-Acetylneuraminic Acid	107-118	sialic acid acetylesterase	Homo sapiens	0-27
26022516-1	2015	Sialic acid acetyl esterase (SIAE) removes acetyl moieties from the hydroxyl groups in position 9 and 4 of sialic acid.	N-Acetylneuraminic Acid	107-118	sialic acid acetylesterase	Homo sapiens	29-33
26105052-3	2015	Myelin-associated glycoprotein (MAG), a member of the sialic acid (SA)-binding immunoglobulin-like lectin family, is mainly expressed in neural tissues.	N-Acetylneuraminic Acid	54-65	myelin associated glycoprotein	Homo sapiens	0-30
26105052-3	2015	Myelin-associated glycoprotein (MAG), a member of the sialic acid (SA)-binding immunoglobulin-like lectin family, is mainly expressed in neural tissues.	N-Acetylneuraminic Acid	54-65	myelin associated glycoprotein	Homo sapiens	32-35
26105052-3	2015	Myelin-associated glycoprotein (MAG), a member of the sialic acid (SA)-binding immunoglobulin-like lectin family, is mainly expressed in neural tissues.	N-Acetylneuraminic Acid	67-69	myelin associated glycoprotein	Homo sapiens	0-30
26105052-3	2015	Myelin-associated glycoprotein (MAG), a member of the sialic acid (SA)-binding immunoglobulin-like lectin family, is mainly expressed in neural tissues.	N-Acetylneuraminic Acid	67-69	myelin associated glycoprotein	Homo sapiens	32-35
26105052-5	2015	The SA requirements of MAG when associating with its ligands vary depending on the specific ligand, but it is unclear whether the SAs on gB are involved in the association with MAG.	N-Acetylneuraminic Acid	4-6	myelin associated glycoprotein	Homo sapiens	23-26
26105052-7	2015	MAG with a point mutation in the SA-binding site did not bind to gB and did not mediate cell-cell fusion or VZV entry.	N-Acetylneuraminic Acid	33-35	myelin associated glycoprotein	Homo sapiens	0-3
25728222-7	2015	Transient transfection of neu-1 or neu3-targeted siRNAs significantly improved the sialic acid content of the Fc-fusion protein in the culture with ammonium addition, indicating that the decreased sialic acid content was in part due to the increased expression level of sialidase.	N-Acetylneuraminic Acid	83-94	sialidase-1	Cricetulus griseus	26-31
25728222-7	2015	Transient transfection of neu-1 or neu3-targeted siRNAs significantly improved the sialic acid content of the Fc-fusion protein in the culture with ammonium addition, indicating that the decreased sialic acid content was in part due to the increased expression level of sialidase.	N-Acetylneuraminic Acid	83-94	sialidase-3	Cricetulus griseus	35-39
25728222-7	2015	Transient transfection of neu-1 or neu3-targeted siRNAs significantly improved the sialic acid content of the Fc-fusion protein in the culture with ammonium addition, indicating that the decreased sialic acid content was in part due to the increased expression level of sialidase.	N-Acetylneuraminic Acid	197-208	sialidase-1	Cricetulus griseus	26-31
25728222-7	2015	Transient transfection of neu-1 or neu3-targeted siRNAs significantly improved the sialic acid content of the Fc-fusion protein in the culture with ammonium addition, indicating that the decreased sialic acid content was in part due to the increased expression level of sialidase.	N-Acetylneuraminic Acid	197-208	sialidase-3	Cricetulus griseus	35-39
24449467-0	2015	Lectin-dependent localization of cell surface sialic acid-binding lectin Siglec-9.	N-Acetylneuraminic Acid	46-57	sialic acid binding Ig like lectin 9	Homo sapiens	73-81
24715531-1	2015	Interleukin-10 (IL-10) expression was significantly elevated upon stimulation with lipopolysaccharide (LPS) when the sialic acid-recognizing Ig-superfamily lectin Siglec-5 or -9 was overexpressed in RAW264 cells.	N-Acetylneuraminic Acid	117-128	interleukin 10	Mus musculus	0-14
24715531-1	2015	Interleukin-10 (IL-10) expression was significantly elevated upon stimulation with lipopolysaccharide (LPS) when the sialic acid-recognizing Ig-superfamily lectin Siglec-5 or -9 was overexpressed in RAW264 cells.	N-Acetylneuraminic Acid	117-128	interleukin 10	Mus musculus	16-21
24715531-1	2015	Interleukin-10 (IL-10) expression was significantly elevated upon stimulation with lipopolysaccharide (LPS) when the sialic acid-recognizing Ig-superfamily lectin Siglec-5 or -9 was overexpressed in RAW264 cells.	N-Acetylneuraminic Acid	117-128	sialic acid binding Ig-like lectin E	Mus musculus	163-177
26050259-5	2015	Fibrin, which is proteolytically produced from fibrinogen by thrombin, binds to the same sugar residues as fibrinogen in the presence of 5 mM Ca(2+), while it markedly binds to N-acetylneuraminic acid in the absence of Ca(2+).	N-Acetylneuraminic Acid	177-200	fibrinogen beta chain	Homo sapiens	47-57
26169044-4	2015	Following cellular approaches, including selective gene knockout by CRISPR/Cas genome editing, we here show that CASD1--a previously identified human candidate gene--is essential for sialic acid 9-O-acetylation.	N-Acetylneuraminic Acid	183-194	CAS1 domain containing 1	Homo sapiens	113-118
26169044-5	2015	In vitro assays with the purified N-terminal luminal domain of CASD1 demonstrate transfer of acetyl groups from acetyl-coenzyme A to CMP-activated sialic acid and formation of a covalent acetyl-enzyme intermediate.	N-Acetylneuraminic Acid	147-158	CAS1 domain containing 1	Homo sapiens	63-68
26169044-5	2015	In vitro assays with the purified N-terminal luminal domain of CASD1 demonstrate transfer of acetyl groups from acetyl-coenzyme A to CMP-activated sialic acid and formation of a covalent acetyl-enzyme intermediate.	N-Acetylneuraminic Acid	147-158	matrilin 1	Homo sapiens	133-136
25850639-1	2015	The key enzyme of sialic acid (Sia) biosynthesis is the bifunctional UDP-N-acetylglucosamine 2-epimerase/ManNAc kinase (GNE/MNK).	N-Acetylneuraminic Acid	18-29	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	120-123
25850639-1	2015	The key enzyme of sialic acid (Sia) biosynthesis is the bifunctional UDP-N-acetylglucosamine 2-epimerase/ManNAc kinase (GNE/MNK).	N-Acetylneuraminic Acid	18-29	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	124-127
25850639-1	2015	The key enzyme of sialic acid (Sia) biosynthesis is the bifunctional UDP-N-acetylglucosamine 2-epimerase/ManNAc kinase (GNE/MNK).	N-Acetylneuraminic Acid	31-34	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	120-123
25850639-1	2015	The key enzyme of sialic acid (Sia) biosynthesis is the bifunctional UDP-N-acetylglucosamine 2-epimerase/ManNAc kinase (GNE/MNK).	N-Acetylneuraminic Acid	31-34	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	124-127
26231298-1	2015	GNE myopathy is an autosomal-recessive disorder caused by mutations in the GNE gene, encoding the key enzyme in the sialic acid biosynthetic pathway, UDP-N-acetylglucosamine 2-epimerase/N-acetyl mannosamine kinase.	N-Acetylneuraminic Acid	116-127	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
26231298-1	2015	GNE myopathy is an autosomal-recessive disorder caused by mutations in the GNE gene, encoding the key enzyme in the sialic acid biosynthetic pathway, UDP-N-acetylglucosamine 2-epimerase/N-acetyl mannosamine kinase.	N-Acetylneuraminic Acid	116-127	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	75-78
26302170-6	2015	The terminal sialic acid of all three glycans is engaged in a unique binding site on TSPyV VP1, which is positioned about 18 A from established sialic acid binding sites of other polyomaviruses.	N-Acetylneuraminic Acid	13-24	structural protein VP1	Trichodysplasia spinulosa-associated polyomavirus	91-94
26302170-6	2015	The terminal sialic acid of all three glycans is engaged in a unique binding site on TSPyV VP1, which is positioned about 18 A from established sialic acid binding sites of other polyomaviruses.	N-Acetylneuraminic Acid	144-155	structural protein VP1	Trichodysplasia spinulosa-associated polyomavirus	91-94
26302170-7	2015	Structure-based mutagenesis of sialic acid-binding residues leads to reduction in cell attachment and pseudovirus infection, demonstrating the physiological relevance of the TSPyV VP1-glycan interaction.	N-Acetylneuraminic Acid	31-42	structural protein VP1	Trichodysplasia spinulosa-associated polyomavirus	180-183
26163592-11	2015	In addition, HDAC3-deficient T cells display decreases in the sialic acid modifications on the cell surface that recruit natural IgM to initiate the classical complement pathway.	N-Acetylneuraminic Acid	62-73	immunoglobulin heavy constant mu	Mus musculus	129-132
26018766-5	2015	With Bcl-xL overexpression, the sialylation of Fc-fusion protein, which was assessed by isoelectric focusing gel and sialic acid content analyses, decreased more slowly toward the end of batch cultures.	N-Acetylneuraminic Acid	117-128	Bcl2-like 1	Rattus norvegicus	5-11
25957418-1	2015	CD22 is a member of the Sialic acid-binding Ig-like lectin (Siglec) family of lectins described to be exclusively present in B lymphocytes and B cell-derived neoplasms.	N-Acetylneuraminic Acid	24-35	CD22 molecule	Homo sapiens	0-4
25870292-1	2015	The antiinflammatory activity of intravenous immunoglobulin (IVIG) is dependent on the presence of sialic acid in the core IgG fragment crystallizable domain (Fc) glycan, resulting in increased conformational flexibility of the CH2 domain with corresponding modulation of Fc receptor (FcR) binding specificity from type I to type II receptors.	N-Acetylneuraminic Acid	99-110	Fc receptor	Mus musculus	272-283
27858732-1	2015	BACKGROUND: GNE myopathy is a rare autosomal recessively inherited muscle disease resulting from mutations in the gene encoding GNE (UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase), a key enzyme in sialic acid biosynthesis.	N-Acetylneuraminic Acid	214-225	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	12-15
27858732-1	2015	BACKGROUND: GNE myopathy is a rare autosomal recessively inherited muscle disease resulting from mutations in the gene encoding GNE (UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase), a key enzyme in sialic acid biosynthesis.	N-Acetylneuraminic Acid	214-225	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	128-131
25708025-8	2015	Removal of sialic acid and O-glycosylations significantly increased CD44 binding by rhPRG4 (P &lt; 0.001).	N-Acetylneuraminic Acid	11-22	CD44 molecule (Indian blood group)	Homo sapiens	68-72
25601457-5	2015	All identified structures, except Neu5Ac(alpha2-3)Gal(beta1-4)Glc (3"-sialyllactose) contained Neu4,5Ac2 (4-O-acetyl-sialic acid).	N-Acetylneuraminic Acid	34-40	sialidase-4	Ornithorhynchus anatinus	95-104
25750127-6	2015	Introduction of a single oxygen atom change into polySia by exogenous feeding of the non-neural sialic acid Neu5Gc (N-glycolylneuraminic acid) caused resistance to Neu1-induced polySia turnover and also inhibited the associated release of brain-derived neurotrophic factor.	N-Acetylneuraminic Acid	96-107	neuraminidase 1	Mus musculus	164-168
25750127-6	2015	Introduction of a single oxygen atom change into polySia by exogenous feeding of the non-neural sialic acid Neu5Gc (N-glycolylneuraminic acid) caused resistance to Neu1-induced polySia turnover and also inhibited the associated release of brain-derived neurotrophic factor.	N-Acetylneuraminic Acid	96-107	brain derived neurotrophic factor	Mus musculus	239-272
25870292-1	2015	The antiinflammatory activity of intravenous immunoglobulin (IVIG) is dependent on the presence of sialic acid in the core IgG fragment crystallizable domain (Fc) glycan, resulting in increased conformational flexibility of the CH2 domain with corresponding modulation of Fc receptor (FcR) binding specificity from type I to type II receptors.	N-Acetylneuraminic Acid	99-110	Fc receptor	Mus musculus	285-288
25497369-8	2015	RESULTS: We detected mouse lung glycoproteins that bound to Siglec-F; binding was sialic acid dependent.	N-Acetylneuraminic Acid	82-93	sialic acid binding Ig-like lectin F	Mus musculus	60-68
25826319-6	2015	A combined analysis of sialic acid in anti-oligomeric Abeta IgG did reveal a notable finding that this subgroup exhibited a high degree of surface sialic acid lacking the conventional alpha2,6 linkage.	N-Acetylneuraminic Acid	23-34	amyloid beta precursor protein	Homo sapiens	54-59
25002140-1	2015	GNE myopathy is an autosomal recessive muscle disease caused by biallelic mutations in GNE, a gene encoding for a single protein with key enzymatic activities, UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase, in sialic acid biosynthetic pathway.	N-Acetylneuraminic Acid	231-242	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
25002140-1	2015	GNE myopathy is an autosomal recessive muscle disease caused by biallelic mutations in GNE, a gene encoding for a single protein with key enzymatic activities, UDP-N-acetylglucosamine 2-epimerase and N-acetylmannosamine kinase, in sialic acid biosynthetic pathway.	N-Acetylneuraminic Acid	231-242	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	87-90
25002140-7	2015	Based upon the pathophysiology of the disease, recent clinical trials as well as early gene therapy trials have evaluated the use of sialic acid or N-acetylmannosamine (a precursor of sialic acid) in patients with GNE myopathy.	N-Acetylneuraminic Acid	133-144	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	214-217
25002140-7	2015	Based upon the pathophysiology of the disease, recent clinical trials as well as early gene therapy trials have evaluated the use of sialic acid or N-acetylmannosamine (a precursor of sialic acid) in patients with GNE myopathy.	N-Acetylneuraminic Acid	184-195	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	214-217
25825024-5	2015	In accordance with these findings, mice treated with the sialic acid precursor N-acetylmannosamine (ManNAc), which results in increased IgG sialylation, are less susceptible to inflammatory bone loss.	N-Acetylneuraminic Acid	57-68	immunoglobulin heavy variable V1-62	Mus musculus	136-139
25552652-0	2015	Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal alpha-dystroglycan O-mannosylation, independent from sialic acid.	N-Acetylneuraminic Acid	25-36	solute carrier family 35 member A1	Homo sapiens	49-56
25552652-3	2015	SLC35A1, encoding the transporter of cytidine 5"-monophosphate-sialic acid, was recently identified as MDDG candidate gene.	N-Acetylneuraminic Acid	63-74	solute carrier family 35 member A1	Homo sapiens	0-7
25846707-2	2015	In this study, we report evidence of a significant correlation between the number of genes encoding the immunomodulatory CD33-related sialic acid-binding immunoglobulin-like receptors (CD33rSiglecs) and maximum lifespan in mammals.	N-Acetylneuraminic Acid	134-145	CD33 molecule	Homo sapiens	121-125
25149037-2	2015	The most common form of HIBM is due to mutations of the GNE gene that codes for a rate-limiting enzyme in the sialic acid biosynthetic pathway.	N-Acetylneuraminic Acid	110-121	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	56-59
25826319-6	2015	A combined analysis of sialic acid in anti-oligomeric Abeta IgG did reveal a notable finding that this subgroup exhibited a high degree of surface sialic acid lacking the conventional alpha2,6 linkage.	N-Acetylneuraminic Acid	147-158	amyloid beta precursor protein	Homo sapiens	54-59
25151992-9	2015	Serum sialic acid also is related to some conventional cardiovascular risk factors including elevated lipid profile, increased blood pressure, increased serum glucose and insulin levels, and insulin resistance in obese people.	N-Acetylneuraminic Acid	6-17	insulin	Homo sapiens	171-178
32262349-7	2015	The hybrid NP system displayed a good sensitivity for SA with a detection limit of 5.1 nM and a concentration dependent fluorescence quenching for SA concentrations ranging from 25 nM to 3.2 muM.	N-Acetylneuraminic Acid	147-149	latexin	Homo sapiens	191-194
25564666-2	2015	In this work, we developed a tissue-based strategy for metabolically incorporating an unnatural monosaccharide, peracetylated N-azidoacetyl-D-mannosamine, in the sialic acid biochemical pathway to present N-azidoacetyl sialic acid to PSA-NCAM.	N-Acetylneuraminic Acid	162-173	neural cell adhesion molecule 1	Homo sapiens	238-242
25534734-0	2015	Sialic acid-binding protein Sp2CBMTD protects mice against lethal challenge with emerging influenza A (H7N9) virus.	N-Acetylneuraminic Acid	0-11	Sp2 transcription factor	Mus musculus	28-31
25641927-6	2015	Furthermore, the total SA (mol/mol) in IgG produced by the enriched ST6GAL1 Clone 27 increased by 2-fold compared to the control.	N-Acetylneuraminic Acid	23-25	beta-galactoside alpha-2,6-sialyltransferase 1	Cricetulus griseus	68-75
25448602-2	2015	CD33 (Siglec-3) is an immune function protein with anti-inflammatory signaling, cell adhesion, and endocytosis functions with sialic acid-modified proteins or lipids as ligands.	N-Acetylneuraminic Acid	126-137	CD33 molecule	Homo sapiens	6-14
25525262-8	2015	However, novel non-enzymatic sialic acid labeling indicated a reduction in sialylation of ST3Gal4(-/-) ventricular Kv4.2 and Kv1.5, which contribute to Ito and IKslow, respectively.	N-Acetylneuraminic Acid	29-40	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Mus musculus	90-97
25525262-8	2015	However, novel non-enzymatic sialic acid labeling indicated a reduction in sialylation of ST3Gal4(-/-) ventricular Kv4.2 and Kv1.5, which contribute to Ito and IKslow, respectively.	N-Acetylneuraminic Acid	29-40	potassium voltage-gated channel, Shal-related family, member 2	Mus musculus	115-120
25525262-8	2015	However, novel non-enzymatic sialic acid labeling indicated a reduction in sialylation of ST3Gal4(-/-) ventricular Kv4.2 and Kv1.5, which contribute to Ito and IKslow, respectively.	N-Acetylneuraminic Acid	29-40	potassium voltage-gated channel, shaker-related subfamily, member 5	Mus musculus	125-130
26328495-7	2015	We identified several mucin-type O-glycans containing (NeuAc)1(Hex)1(HexNAc)1, (NeuAc)2(Hex)1(HexNAc)1, and (NeuAc)2(Hex)2(HexNAc)2.	N-Acetylneuraminic Acid	55-60	LOC100508689	Homo sapiens	22-27
26235586-8	2015	HPLC analysis showed conversion of CMP-Neu5Ac to CMP-Neu5Gc by the secretory CMAH.	N-Acetylneuraminic Acid	39-45	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	77-81
25151992-9	2015	Serum sialic acid also is related to some conventional cardiovascular risk factors including elevated lipid profile, increased blood pressure, increased serum glucose and insulin levels, and insulin resistance in obese people.	N-Acetylneuraminic Acid	6-17	insulin	Homo sapiens	191-198
26118196-6	2015	RESULTS: There were significant correlations between SA and fibrinogen, D-dimer, factor (F) IX, and platelet (PLT) that were independent of smoking, body mass index (BMI), waist-to-hip ratio, hemoglobin A(1c) (HbA1c), fasting plasma glucose (FPG), triglycerides (TG), total cholesterol (TC) to high-density lipoprotein cholesterol (HDL-C) ratio, and antithrombotic therapy history.	N-Acetylneuraminic Acid	53-55	fibrinogen beta chain	Homo sapiens	60-70
25261856-5	2015	The N-glycans found in the CSF were predominantly complex diantennary with sialic acid in alpha2,3- and alpha2,6-linkage, and bisecting N-acetylglucosamine-containing structures as well as peripherally fucosylated structures were found.	N-Acetylneuraminic Acid	75-86	immunoglobulin kappa variable 2-24	Homo sapiens	90-99
25117008-3	2015	The present study reports the enrichment of IFN-beta-1a glycoforms and their physicochemical and biological characterization by means of electrospray ionization-mass spectrometry, sialic acid content, thermal denaturation and various in vitro bioassays (antiproliferative, antiviral, immunomodulatory and reporter gene assay).	N-Acetylneuraminic Acid	180-191	interferon beta 1	Homo sapiens	44-52
25280627-5	2015	When expressed on transfected cells, porcine Siglec-10 was able to bind red blood cells in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	93-104	sialic acid binding Ig like lectin 10	Homo sapiens	45-54
25892842-4	2015	The following findings emerge from our studies: (1) in human seminal plasma the presence and alterations of O-linked glycans were observed; (2) the expression of SNA-reactive sialic acid significantly differs between asthenozoospermia and both normozoospermic (fertile and infertile) groups; (3) the expression of PHA-L-reactive highly branched N-glycans was significantly lower in oligozoospermic patients than in both normozoospermic groups.	N-Acetylneuraminic Acid	175-186	snail family transcriptional repressor 1	Homo sapiens	162-165
25213400-11	2015	The most mannose rich are the glycans MS2 and GP4, each of them has four mannoses; OPPE1 contains five N-acetylglucosamines and one sulfated glucuronic acid; GP4 contains one sialic acid.	N-Acetylneuraminic Acid	175-186	CD36 molecule	Homo sapiens	158-161
25712316-6	2015	Release of sialic acid (from biofilm) and neuraminidase activity were measured using enzymatic and HPLC-MS detection of sialic acid.	N-Acetylneuraminic Acid	120-131	neuraminidase 1	Homo sapiens	42-55
25910046-3	2015	Together with computational molecular docking, all three catechins were found to bind to influenza neuraminidase in the vicinity of a structurally conserved cavity adjacent to residue 430 that has been suggested to be a secondary sialic acid binding site.	N-Acetylneuraminic Acid	230-241	neuraminidase 1	Homo sapiens	99-112
25530638-3	2015	Our group has recently shown that a trifluorobutyryl-modified sialic acid metabolite diminishes the adhesion of mammalian cells to E and P-selectin, presumably by leading to the expression of fluorinated sLex epitopes on cell surfaces, and interfering with the sLex-selectin interactions that are well known in mediating tumor cell migration.1 For studies directed towards understanding the molecular basis of this reduced adhesion, chemical synthesis of trifluorobutyrylated sialyl Lewis x (C4F3--sLex) was crucial.	N-Acetylneuraminic Acid	62-73	selectin P	Homo sapiens	137-147
25402769-0	2015	Structural basis for sialic acid-mediated self-recognition by complement factor H.	N-Acetylneuraminic Acid	21-32	complement factor H	Homo sapiens	73-81
25329332-2	2015	During polysialylation, both STX and PST catalyze the transfer of multiple Sia residues from the activated sugar nucleotide precursor, CMP-Neu5Ac (Sia), to terminal Sia residues on N- and Olinked oligosaccharide chains on acceptor glycoproteins, including the neural cell adhesion molecule (NCAM), which is the major carrier protein of polySia.	N-Acetylneuraminic Acid	139-145	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	29-32
25329332-2	2015	During polysialylation, both STX and PST catalyze the transfer of multiple Sia residues from the activated sugar nucleotide precursor, CMP-Neu5Ac (Sia), to terminal Sia residues on N- and Olinked oligosaccharide chains on acceptor glycoproteins, including the neural cell adhesion molecule (NCAM), which is the major carrier protein of polySia.	N-Acetylneuraminic Acid	139-145	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	37-40
25329332-2	2015	During polysialylation, both STX and PST catalyze the transfer of multiple Sia residues from the activated sugar nucleotide precursor, CMP-Neu5Ac (Sia), to terminal Sia residues on N- and Olinked oligosaccharide chains on acceptor glycoproteins, including the neural cell adhesion molecule (NCAM), which is the major carrier protein of polySia.	N-Acetylneuraminic Acid	139-145	neural cell adhesion molecule 1	Homo sapiens	260-289
25329332-2	2015	During polysialylation, both STX and PST catalyze the transfer of multiple Sia residues from the activated sugar nucleotide precursor, CMP-Neu5Ac (Sia), to terminal Sia residues on N- and Olinked oligosaccharide chains on acceptor glycoproteins, including the neural cell adhesion molecule (NCAM), which is the major carrier protein of polySia.	N-Acetylneuraminic Acid	139-145	neural cell adhesion molecule 1	Homo sapiens	291-295
23842869-0	2015	UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis.	N-Acetylneuraminic Acid	66-77	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	38-41
23842869-1	2015	UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase is the key enzyme of sialic acid biosynthesis in vertebrates.	N-Acetylneuraminic Acid	84-95	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-62
24141690-5	2015	In this chapter we focus on the enzyme catalyzing the activation of sialic acid, the CMP-sialic acid synthetase (CMAS), and compare the enzymatic properties of CMASs isolated from different species.	N-Acetylneuraminic Acid	68-79	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	85-111
25480294-4	2014	Human glycans are unusual because of the lack of CMAH, which in other mammals converts N-acetylneuraminic acid (Neu5Ac) to N-glycolylneuraminic acid (Neu5Gc).	N-Acetylneuraminic Acid	87-110	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	49-53
24276958-1	2015	Siglec-4, also known as myelin-associated glycoprotein (MAG), is a member of the siglec (sialic acid-binding immunoglobulin-like lectins) family.	N-Acetylneuraminic Acid	89-100	myelin associated glycoprotein	Homo sapiens	24-54
24276958-1	2015	Siglec-4, also known as myelin-associated glycoprotein (MAG), is a member of the siglec (sialic acid-binding immunoglobulin-like lectins) family.	N-Acetylneuraminic Acid	89-100	myelin associated glycoprotein	Homo sapiens	56-59
24276958-3	2015	Although the involvement and relevance of its sialic acid binding activity is still controversial, it could be demonstrated that interactions of MAG with sialylated gangliosides play an important role in axon stability and regeneration.	N-Acetylneuraminic Acid	46-57	myelin associated glycoprotein	Homo sapiens	145-148
25517696-2	2014	Neu5Gc is synthesized from Neu5Ac by the enzyme cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH).	N-Acetylneuraminic Acid	27-33	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	48-106
25517696-2	2014	Neu5Gc is synthesized from Neu5Ac by the enzyme cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH).	N-Acetylneuraminic Acid	27-33	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	108-112
25339691-3	2014	Neuraminidase cleaves N-acetyl neuraminic acid residues of glycoproteins and targets the sialic acid component of the glycocalyx on the cell membrane.	N-Acetylneuraminic Acid	22-46	neuraminidase 1	Homo sapiens	0-13
25339691-3	2014	Neuraminidase cleaves N-acetyl neuraminic acid residues of glycoproteins and targets the sialic acid component of the glycocalyx on the cell membrane.	N-Acetylneuraminic Acid	89-100	neuraminidase 1	Homo sapiens	0-13
25480294-4	2014	Human glycans are unusual because of the lack of CMAH, which in other mammals converts N-acetylneuraminic acid (Neu5Ac) to N-glycolylneuraminic acid (Neu5Gc).	N-Acetylneuraminic Acid	112-118	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	49-53
25257349-1	2014	GNE myopathy is an autosomal recessive muscular disorder caused by mutations in the gene encoding the key enzyme in sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE/MNK).	N-Acetylneuraminic Acid	116-127	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
25458834-8	2014	Carboxyl groups from the sialic acid residue on podoplanin and from the C terminus of the rhodocytin alpha subunit interact differently at this "second" binding site on CLEC-2.	N-Acetylneuraminic Acid	25-36	C-type lectin domain family 1 member B	Homo sapiens	169-175
25465919-2	2014	Accumulating evidence shows that ST6GAL1, an enzyme that catalyzes the transfer of sialic acid onto galactose-containing substrates, is aberrantly expressed in various cancers and may affect cell motility and invasion.	N-Acetylneuraminic Acid	83-94	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	33-40
25182749-1	2014	GNE myopathy is a rare autosomal recessive muscle disease caused by mutations in GNE, the gene encoding the rate-limiting enzyme in sialic acid biosynthesis.	N-Acetylneuraminic Acid	132-143	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
25182749-1	2014	GNE myopathy is a rare autosomal recessive muscle disease caused by mutations in GNE, the gene encoding the rate-limiting enzyme in sialic acid biosynthesis.	N-Acetylneuraminic Acid	132-143	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	81-84
25257349-1	2014	GNE myopathy is an autosomal recessive muscular disorder caused by mutations in the gene encoding the key enzyme in sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE/MNK).	N-Acetylneuraminic Acid	116-127	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	142-204
25257349-1	2014	GNE myopathy is an autosomal recessive muscular disorder caused by mutations in the gene encoding the key enzyme in sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE/MNK).	N-Acetylneuraminic Acid	116-127	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	206-209
25257349-1	2014	GNE myopathy is an autosomal recessive muscular disorder caused by mutations in the gene encoding the key enzyme in sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE/MNK).	N-Acetylneuraminic Acid	116-127	ATPase copper transporting alpha	Homo sapiens	210-213
25252961-5	2014	CD22 and Siglec-G are recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn and the proapoptotic factor BIM that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge.	N-Acetylneuraminic Acid	64-75	CD22 antigen	Mus musculus	0-4
25320078-2	2014	The CD33-related subset of sialic acid-binding immunoglobulin-like lectins (Siglecs) consists of immunomodulatory molecules that have recently been associated with the modulation of immune responses to cancer.	N-Acetylneuraminic Acid	27-38	CD33 molecule	Homo sapiens	4-8
25320078-4	2014	Here we used affinity chromatography of tumor cell extracts to identify LGALS3BP as a novel sialic acid-dependent ligand for human Siglec-9 and for other immunomodulatory Siglecs, such as Siglec-5 and Siglec-10.	N-Acetylneuraminic Acid	92-103	galectin 3 binding protein	Homo sapiens	72-80
25320078-4	2014	Here we used affinity chromatography of tumor cell extracts to identify LGALS3BP as a novel sialic acid-dependent ligand for human Siglec-9 and for other immunomodulatory Siglecs, such as Siglec-5 and Siglec-10.	N-Acetylneuraminic Acid	92-103	sialic acid binding Ig like lectin 9	Homo sapiens	131-139
25320078-4	2014	Here we used affinity chromatography of tumor cell extracts to identify LGALS3BP as a novel sialic acid-dependent ligand for human Siglec-9 and for other immunomodulatory Siglecs, such as Siglec-5 and Siglec-10.	N-Acetylneuraminic Acid	92-103	sialic acid binding Ig like lectin 5	Homo sapiens	188-196
25320078-4	2014	Here we used affinity chromatography of tumor cell extracts to identify LGALS3BP as a novel sialic acid-dependent ligand for human Siglec-9 and for other immunomodulatory Siglecs, such as Siglec-5 and Siglec-10.	N-Acetylneuraminic Acid	92-103	sialic acid binding Ig like lectin 10	Homo sapiens	201-210
25320078-7	2014	Finally, LGALS3BP was able to inhibit neutrophil activation in a sialic acid- and Siglec-dependent manner.	N-Acetylneuraminic Acid	65-76	galectin 3 binding protein	Homo sapiens	9-17
25299151-4	2014	For instance, previous studies have shown that the ratio of alpha2-3 to alpha2-6 linked sialic acid (SA) plays an important role in cancer biology.	N-Acetylneuraminic Acid	88-99	immunoglobulin binding protein 1	Homo sapiens	72-80
25299151-4	2014	For instance, previous studies have shown that the ratio of alpha2-3 to alpha2-6 linked sialic acid (SA) plays an important role in cancer biology.	N-Acetylneuraminic Acid	101-103	immunoglobulin binding protein 1	Homo sapiens	72-80
25277834-0	2014	Chemical synthesis of a synthetic analogue of the sialic acid-binding lectin siglec-7.	N-Acetylneuraminic Acid	50-61	sialic acid binding Ig like lectin 7	Homo sapiens	77-85
25277834-1	2014	As a basis for the development of an artificial carbohydrate-binding lectin, we chemically synthesized a domain of siglec-7, a well-characterized sialic-acid-binding lectin.	N-Acetylneuraminic Acid	146-157	sialic acid binding Ig like lectin 7	Homo sapiens	115-123
25277834-4	2014	After folding the full-length polypeptide, the sialic-acid-binding activity of the synthetic siglec-7 was clearly demonstrated by STD NMR and ELISA experiments.	N-Acetylneuraminic Acid	47-58	sialic acid binding Ig like lectin 7	Homo sapiens	93-101
25331875-4	2014	Proteoglycans from FAM20B knockout cells contain a truncated tetrasaccharide linkage region consisting of a disaccharide capped with sialic acid (Siaalpha2-3Galbeta1-4Xylbeta1) that cannot be further elongated.	N-Acetylneuraminic Acid	133-144	FAM20B glycosaminoglycan xylosylkinase	Homo sapiens	19-25
25252961-5	2014	CD22 and Siglec-G are recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn and the proapoptotic factor BIM that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge.	N-Acetylneuraminic Acid	64-75	sialic acid binding Ig-like lectin G	Mus musculus	9-17
25252961-5	2014	CD22 and Siglec-G are recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn and the proapoptotic factor BIM that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge.	N-Acetylneuraminic Acid	64-75	LYN proto-oncogene, Src family tyrosine kinase	Mus musculus	150-153
25135639-8	2014	Collectively, these findings suggest that PECAM is a sialic acid binding lectin and that this binding property supports endothelial cell survival.	N-Acetylneuraminic Acid	53-64	platelet and endothelial cell adhesion molecule 1	Homo sapiens	42-47
24976248-2	2014	Recent studies have demonstrated that cold temperature (CT) stored PLTs secrete sialidases upon re-warming, removing sialic acid from the PLT surface, which may be responsible for clustering of GPIbalpha and PLT clearance from circulation.	N-Acetylneuraminic Acid	117-128	glycoprotein Ib platelet subunit alpha	Homo sapiens	194-203
24744226-7	2014	The neu4 considerably cleaved sialic acid from 4-methylumbelliferyl-N-acetyl-alpha-D-neuraminic acid and sialyllactose, but not from ganglioside and fetuin, which are good substrates for human NEU4.	N-Acetylneuraminic Acid	30-41	neuraminidase 4	Homo sapiens	4-8
25062695-2	2014	To elucidate whether GNE myopathy is treatable at a progressive stage of the disease, we examined the efficacy of sialic acid supplementation on symptomatic old GNE myopathy mice that have ongoing, active muscle degeneration.	N-Acetylneuraminic Acid	114-125	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	161-164
25062695-3	2014	We examined the therapeutic effect of a less metabolized sialic acid compound (6"-sialyllactose) or free sialic acid (N-acetylneuraminic acid) by oral, continuous administration to 50-week-old GNE myopathy mice for 30 weeks.	N-Acetylneuraminic Acid	57-68	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	193-196
24744226-7	2014	The neu4 considerably cleaved sialic acid from 4-methylumbelliferyl-N-acetyl-alpha-D-neuraminic acid and sialyllactose, but not from ganglioside and fetuin, which are good substrates for human NEU4.	N-Acetylneuraminic Acid	30-41	neuraminidase 4	Homo sapiens	193-197
25198831-6	2014	These findings shed light on the importance of C-5 substitution on Neu5Ac2en in the design of novel sialic acid-based inhibitors that target human parainfluenza type-1 hemagglutinin-neuraminidase.	N-Acetylneuraminic Acid	100-111	complement C5	Homo sapiens	47-50
24474513-1	2014	Hereditary inclusion body myopathy (GNE myopathy) is a neuromuscular disorder due to mutation in key sialic acid biosynthetic enzyme, GNE.	N-Acetylneuraminic Acid	101-112	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	36-39
24474513-1	2014	Hereditary inclusion body myopathy (GNE myopathy) is a neuromuscular disorder due to mutation in key sialic acid biosynthetic enzyme, GNE.	N-Acetylneuraminic Acid	101-112	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	134-137
24474513-2	2014	The pathomechanism of the disease is poorly understood as GNE is involved in other cellular functions beside sialic acid synthesis.	N-Acetylneuraminic Acid	109-120	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	58-61
24474513-6	2014	Hyposialylated beta1-integrin localized to internal vesicles that was restored upon supplementation with sialic acid.	N-Acetylneuraminic Acid	105-116	integrin subunit beta 1	Homo sapiens	15-29
25137483-4	2014	We observed an increase in alpha2,3-linked sialic acid residues on alpha2 subunits of alpha2beta1 integrin receptors, correlating with increased gene expression of alpha2,3-STs (sialyltransferases), particularly ST3GAL3.	N-Acetylneuraminic Acid	43-54	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	212-219
25059667-0	2014	Negative regulation of Toll-like receptor-4 signaling through the binding of glycosylphosphatidylinositol-anchored glycoprotein, CD14, with the sialic acid-binding lectin, CD33.	N-Acetylneuraminic Acid	144-155	toll like receptor 4	Homo sapiens	23-43
25222608-1	2014	The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes.	N-Acetylneuraminic Acid	15-26	neuraminidase 1	Homo sapiens	147-151
25222608-1	2014	The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes.	N-Acetylneuraminic Acid	15-26	neuraminidase 2	Homo sapiens	153-157
25222608-1	2014	The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes.	N-Acetylneuraminic Acid	15-26	neuraminidase 3	Homo sapiens	159-163
25222608-1	2014	The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes.	N-Acetylneuraminic Acid	15-26	neuraminidase 4	Homo sapiens	168-172
25222608-1	2014	The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes.	N-Acetylneuraminic Acid	28-31	neuraminidase 1	Homo sapiens	147-151
25222608-1	2014	The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes.	N-Acetylneuraminic Acid	28-31	neuraminidase 2	Homo sapiens	153-157
25222608-1	2014	The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes.	N-Acetylneuraminic Acid	28-31	neuraminidase 3	Homo sapiens	159-163
25222608-1	2014	The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes.	N-Acetylneuraminic Acid	28-31	neuraminidase 4	Homo sapiens	168-172
25222608-4	2014	We found significant differences in substrate specificity of the enzymes towards the substrates containing alpha2,6-linked Sia, which were readily cleaved by Neu3 and Neu1 but not by Neu4 and Neu2.	N-Acetylneuraminic Acid	123-126	neuraminidase 3	Homo sapiens	158-162
25222608-4	2014	We found significant differences in substrate specificity of the enzymes towards the substrates containing alpha2,6-linked Sia, which were readily cleaved by Neu3 and Neu1 but not by Neu4 and Neu2.	N-Acetylneuraminic Acid	123-126	neuraminidase 1	Homo sapiens	167-171
25222608-4	2014	We found significant differences in substrate specificity of the enzymes towards the substrates containing alpha2,6-linked Sia, which were readily cleaved by Neu3 and Neu1 but not by Neu4 and Neu2.	N-Acetylneuraminic Acid	123-126	neuraminidase 4	Homo sapiens	183-187
25222608-4	2014	We found significant differences in substrate specificity of the enzymes towards the substrates containing alpha2,6-linked Sia, which were readily cleaved by Neu3 and Neu1 but not by Neu4 and Neu2.	N-Acetylneuraminic Acid	123-126	neuraminidase 2	Homo sapiens	192-196
24924144-9	2014	Mouse Siglec-E of microglia binds to alpha2.8- and alpha2.3-linked sialic acid residues of the healthy glycocalyx of neuronal and glial cells.	N-Acetylneuraminic Acid	67-78	sialic acid binding Ig-like lectin E	Mus musculus	6-14
25059667-0	2014	Negative regulation of Toll-like receptor-4 signaling through the binding of glycosylphosphatidylinositol-anchored glycoprotein, CD14, with the sialic acid-binding lectin, CD33.	N-Acetylneuraminic Acid	144-155	CD14 molecule	Homo sapiens	129-133
25059667-0	2014	Negative regulation of Toll-like receptor-4 signaling through the binding of glycosylphosphatidylinositol-anchored glycoprotein, CD14, with the sialic acid-binding lectin, CD33.	N-Acetylneuraminic Acid	144-155	CD33 molecule	Homo sapiens	172-176
25059667-5	2014	Sialic acid-dependent binding of CD33 to CD14 was confirmed by a plate assay using recombinant CD33 and CD14.	N-Acetylneuraminic Acid	0-11	CD33 molecule	Homo sapiens	33-37
25059667-5	2014	Sialic acid-dependent binding of CD33 to CD14 was confirmed by a plate assay using recombinant CD33 and CD14.	N-Acetylneuraminic Acid	0-11	CD14 molecule	Homo sapiens	41-45
25059667-5	2014	Sialic acid-dependent binding of CD33 to CD14 was confirmed by a plate assay using recombinant CD33 and CD14.	N-Acetylneuraminic Acid	0-11	CD33 molecule	Homo sapiens	95-99
25059667-5	2014	Sialic acid-dependent binding of CD33 to CD14 was confirmed by a plate assay using recombinant CD33 and CD14.	N-Acetylneuraminic Acid	0-11	CD14 molecule	Homo sapiens	104-108
25002414-0	2014	CD22 and Siglec-G regulate inhibition of B-cell signaling by sialic acid ligand binding and control B-cell tolerance.	N-Acetylneuraminic Acid	61-72	CD22 molecule	Homo sapiens	0-4
24893855-7	2014	Modulation of CD8 T cell sialic acid with neuraminidase and ST3Gal-II revealed de-sialylation was necessary and sufficient for promiscuous binding to and stimulation by tumor pMHC I.	N-Acetylneuraminic Acid	25-36	CD8a molecule	Homo sapiens	14-17
24893855-7	2014	Modulation of CD8 T cell sialic acid with neuraminidase and ST3Gal-II revealed de-sialylation was necessary and sufficient for promiscuous binding to and stimulation by tumor pMHC I.	N-Acetylneuraminic Acid	25-36	neuraminidase 1	Homo sapiens	42-55
24993898-1	2014	We describe here a 34 months child, practically asymptomatic which presented with high levels of free sialic acid in urine by biochemical detection in second-tier tests newborn screening and with two disease causing mutations in SLC17A5 gene.	N-Acetylneuraminic Acid	102-113	solute carrier family 17 member 5	Homo sapiens	229-236
24833613-7	2014	Furthermore, microglial mouse Siglec-E and human Siglec-11 have been shown to prevent neurotoxicity via interaction with sialic acid exposed on the neuronal glycocalyx.	N-Acetylneuraminic Acid	121-132	sialic acid binding Ig-like lectin E	Mus musculus	30-38
24833613-7	2014	Furthermore, microglial mouse Siglec-E and human Siglec-11 have been shown to prevent neurotoxicity via interaction with sialic acid exposed on the neuronal glycocalyx.	N-Acetylneuraminic Acid	121-132	sialic acid binding Ig like lectin 11	Homo sapiens	49-58
25002414-1	2014	CD22 and Siglec-G are two B-cell expressed members of the Siglec (sialic acid-binding immunoglobulin (Ig)-like lectin) family and are potent inhibitors of B-cell signaling.	N-Acetylneuraminic Acid	66-77	CD22 molecule	Homo sapiens	0-4
25002414-4	2014	In contrast, Siglec-G is recruited via sialic acid binding to the BCR.	N-Acetylneuraminic Acid	39-50	BCR activator of RhoGEF and GTPase	Homo sapiens	66-69
24684244-7	2014	Sialoadhesin is constitutively expressed upon splenic marginal zone metallophilic and lymph node sub-capsular sinus macrophage populations, where it may function to bind sialylated glycoproteins, pathogens and exosomes in the blood and lymph via recognition of terminal sialic acid residues.	N-Acetylneuraminic Acid	270-281	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	0-12
24876305-3	2014	Treatment of cells with neuraminidase (NA) enhanced infection efficiency, showing that terminal sialic acid residues on the cell surface were not receptor determinants and even hampered efficient virus-receptor engagement.	N-Acetylneuraminic Acid	96-107	neuraminidase 1	Homo sapiens	24-37
25153125-1	2014	The NEU1 gene is the first identified member of the human sialidases, glycohydrolitic enzymes that remove the terminal sialic acid from oligosaccharide chains.	N-Acetylneuraminic Acid	119-130	neuraminidase 1	Homo sapiens	4-8
24973090-0	2014	Sialic acid rescues repurified lipopolysaccharide-induced acute renal failure via inhibiting TLR4/PKC/gp91-mediated endoplasmic reticulum stress, apoptosis, autophagy, and pyroptosis signaling.	N-Acetylneuraminic Acid	0-11	toll-like receptor 4	Rattus norvegicus	93-97
24973090-0	2014	Sialic acid rescues repurified lipopolysaccharide-induced acute renal failure via inhibiting TLR4/PKC/gp91-mediated endoplasmic reticulum stress, apoptosis, autophagy, and pyroptosis signaling.	N-Acetylneuraminic Acid	0-11	protein kinase C, gamma	Rattus norvegicus	98-101
24973090-7	2014	SA treatment at 30 min, but not 60 min after rLPS stimulation, gp91 siRNA and protein kinase C-alpha (PKC) inhibitor efficiently rescued rLPS-induced acute renal failure via inhibition of TLR4/PKC/NADPH oxidase gp91-mediated ER stress, apoptosis, autophagy and pyroptosis in renal proximal tubular cells, and rat kidneys.	N-Acetylneuraminic Acid	0-2	protein kinase C, gamma	Rattus norvegicus	102-105
24973090-7	2014	SA treatment at 30 min, but not 60 min after rLPS stimulation, gp91 siRNA and protein kinase C-alpha (PKC) inhibitor efficiently rescued rLPS-induced acute renal failure via inhibition of TLR4/PKC/NADPH oxidase gp91-mediated ER stress, apoptosis, autophagy and pyroptosis in renal proximal tubular cells, and rat kidneys.	N-Acetylneuraminic Acid	0-2	toll-like receptor 4	Rattus norvegicus	188-192
24973090-7	2014	SA treatment at 30 min, but not 60 min after rLPS stimulation, gp91 siRNA and protein kinase C-alpha (PKC) inhibitor efficiently rescued rLPS-induced acute renal failure via inhibition of TLR4/PKC/NADPH oxidase gp91-mediated ER stress, apoptosis, autophagy and pyroptosis in renal proximal tubular cells, and rat kidneys.	N-Acetylneuraminic Acid	0-2	protein kinase C, gamma	Rattus norvegicus	193-196
24973090-10	2014	In conclusion, early treatment (within 30 min) of SA attenuates rLPS-induced renal failure via the reduction in LPS toxicity and subsequently inhibiting rLPS-activated TLR4/PKC/gp91/ER stress/apoptosis/autophagy/pyroptosis signaling.	N-Acetylneuraminic Acid	50-52	toll-like receptor 4	Rattus norvegicus	168-172
24973090-10	2014	In conclusion, early treatment (within 30 min) of SA attenuates rLPS-induced renal failure via the reduction in LPS toxicity and subsequently inhibiting rLPS-activated TLR4/PKC/gp91/ER stress/apoptosis/autophagy/pyroptosis signaling.	N-Acetylneuraminic Acid	50-52	protein kinase C, gamma	Rattus norvegicus	173-176
25061947-1	2014	It has been known for many years that influenza viruses bind by their hemagglutinin surface glycoprotein to sialic acid (N-acetylneuraminic acid) on the surface of the host cell, and that avian viruses most commonly bind to sialic acid linked alpha2-3 to galactose while most human viruses bind to sialic acid in the alpha2-6 configuration.	N-Acetylneuraminic Acid	108-119	immunoglobulin binding protein 1	Homo sapiens	317-325
25098744-11	2014	Engagement of Siglec-9 via Sia enhanced neutrophils killing of KP-M1 by ex vivo human neutrophils bactericidal activity assay.	N-Acetylneuraminic Acid	27-30	sialic acid binding Ig like lectin 9	Homo sapiens	14-22
25061947-1	2014	It has been known for many years that influenza viruses bind by their hemagglutinin surface glycoprotein to sialic acid (N-acetylneuraminic acid) on the surface of the host cell, and that avian viruses most commonly bind to sialic acid linked alpha2-3 to galactose while most human viruses bind to sialic acid in the alpha2-6 configuration.	N-Acetylneuraminic Acid	121-144	immunoglobulin binding protein 1	Homo sapiens	317-325
24027297-2	2014	It is caused by mutations in the gene encoding a key enzyme in sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE).	N-Acetylneuraminic Acid	63-74	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	89-151
24859880-1	2014	The sialic-acid-binding immunoglobulin-like lectin SIGLEC-G is a negative regulator of B-cell receptor-mediated calcium signaling.	N-Acetylneuraminic Acid	4-15	sialic acid binding Ig-like lectin G	Mus musculus	51-59
24796702-1	2014	The GNE gene encodes the rate-limiting, bifunctional enzyme of sialic acid biosynthesis, uridine diphosphate-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE).	N-Acetylneuraminic Acid	63-74	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	4-7
24796702-1	2014	The GNE gene encodes the rate-limiting, bifunctional enzyme of sialic acid biosynthesis, uridine diphosphate-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE).	N-Acetylneuraminic Acid	63-74	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	169-172
24027297-2	2014	It is caused by mutations in the gene encoding a key enzyme in sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE).	N-Acetylneuraminic Acid	63-74	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	153-156
24048908-0	2014	Mutation analysis of a large cohort of GNE myopathy reveals a diverse array of GNE mutations affecting sialic acid biosynthesis.	N-Acetylneuraminic Acid	103-114	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	39-42
24048908-0	2014	Mutation analysis of a large cohort of GNE myopathy reveals a diverse array of GNE mutations affecting sialic acid biosynthesis.	N-Acetylneuraminic Acid	103-114	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	79-82
24872420-6	2014	Because the gp120 vaccine immunogens used in previous HIV-1 vaccine trials were enriched for complex sialic acid-containing glycans, and lacked the high mannose structures required for the binding of PG9-like mAbs, we wondered if these immunogens could be improved by limiting glycosylation to mannose-5 glycans.	N-Acetylneuraminic Acid	101-112	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	12-17
24807582-3	2014	Here we report design, synthesis, and affinity evaluation of novel sialoside classes with combined modification at positions 2, 4, and 9 or 2, 3, 4, and 9 of the sialic acid scaffold as human CD22 (human Siglec-2) ligands.	N-Acetylneuraminic Acid	162-173	CD22 molecule	Homo sapiens	192-196
24807582-3	2014	Here we report design, synthesis, and affinity evaluation of novel sialoside classes with combined modification at positions 2, 4, and 9 or 2, 3, 4, and 9 of the sialic acid scaffold as human CD22 (human Siglec-2) ligands.	N-Acetylneuraminic Acid	162-173	CD22 molecule	Homo sapiens	204-212
24918438-5	2014	Distribution of NeuAc in IgA1 O-glycans may play an important role in the pathogenesis of IgAN.	N-Acetylneuraminic Acid	16-21	immunoglobulin heavy constant alpha 1	Homo sapiens	25-29
24895121-1	2014	Siglec-E is a sialic acid-binding Ig-like lectin expressed on murine myeloid cells.	N-Acetylneuraminic Acid	14-25	sialic acid binding Ig-like lectin E	Mus musculus	0-8
24895121-3	2014	Here, we demonstrate that siglec-E promoted neutrophil production of reactive oxygen species (ROS) following CD11b beta2-integrin ligation with fibrinogen in a sialic acid-dependent manner, but it had no effect on ROS triggered by a variety of other stimulants.	N-Acetylneuraminic Acid	160-171	sialic acid binding Ig-like lectin E	Mus musculus	26-34
24909815-3	2014	Dynamic simulations were carried out on the analogues of GM3 varying in the substituents at C-1, C-4, C-5, C-8 and C-9 positions of their sialic acid or Neuraminic acid (NeuAc) residue.	N-Acetylneuraminic Acid	138-149	complement C9	Homo sapiens	115-118
24763061-2	2014	CD22 and Siglec-G are two inhibitory receptors of the sialic-acid-binding immunoglobulin-like lectin (Siglec) family that inhibit the B-cell antigen receptor (BCR) signal.	N-Acetylneuraminic Acid	54-65	CD22 molecule	Homo sapiens	0-4
24763061-2	2014	CD22 and Siglec-G are two inhibitory receptors of the sialic-acid-binding immunoglobulin-like lectin (Siglec) family that inhibit the B-cell antigen receptor (BCR) signal.	N-Acetylneuraminic Acid	54-65	sialic acid binding Ig-like lectin G	Mus musculus	9-17
24763061-2	2014	CD22 and Siglec-G are two inhibitory receptors of the sialic-acid-binding immunoglobulin-like lectin (Siglec) family that inhibit the B-cell antigen receptor (BCR) signal.	N-Acetylneuraminic Acid	54-65	BCR activator of RhoGEF and GTPase	Homo sapiens	134-157
24763061-2	2014	CD22 and Siglec-G are two inhibitory receptors of the sialic-acid-binding immunoglobulin-like lectin (Siglec) family that inhibit the B-cell antigen receptor (BCR) signal.	N-Acetylneuraminic Acid	54-65	BCR activator of RhoGEF and GTPase	Homo sapiens	159-162
25018864-10	2014	Removal of sialic acid modifications by neuraminidase treatment increased the amount of control PC3-EVs internalized by RAW264.7 cells, without affecting cavin-1-PC3-EVs.	N-Acetylneuraminic Acid	11-22	proprotein convertase subtilisin/kexin type 1	Mus musculus	96-99
24488768-1	2014	GNE Myopathy is a rare recessively inherited neuromuscular disorder caused by mutations in the GNE gene, which codes for the key enzyme in the metabolic pathway of sialic acid synthesis.	N-Acetylneuraminic Acid	164-175	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Danio rerio	0-3
24488768-1	2014	GNE Myopathy is a rare recessively inherited neuromuscular disorder caused by mutations in the GNE gene, which codes for the key enzyme in the metabolic pathway of sialic acid synthesis.	N-Acetylneuraminic Acid	164-175	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Danio rerio	95-98
24918438-1	2014	Patients with IgA nephropathy (IgAN) have elevated circulating levels of IgA1 with some O-glycans consisting of galactose (Gal)-deficient N-acetylgalactosamine (GalNAc) with or without N-acetylneuraminic acid (NeuAc).	N-Acetylneuraminic Acid	185-208	IGAN1	Homo sapiens	31-35
24918438-1	2014	Patients with IgA nephropathy (IgAN) have elevated circulating levels of IgA1 with some O-glycans consisting of galactose (Gal)-deficient N-acetylgalactosamine (GalNAc) with or without N-acetylneuraminic acid (NeuAc).	N-Acetylneuraminic Acid	185-208	immunoglobulin heavy constant alpha 1	Homo sapiens	73-77
24918438-1	2014	Patients with IgA nephropathy (IgAN) have elevated circulating levels of IgA1 with some O-glycans consisting of galactose (Gal)-deficient N-acetylgalactosamine (GalNAc) with or without N-acetylneuraminic acid (NeuAc).	N-Acetylneuraminic Acid	210-215	IGAN1	Homo sapiens	31-35
24918438-1	2014	Patients with IgA nephropathy (IgAN) have elevated circulating levels of IgA1 with some O-glycans consisting of galactose (Gal)-deficient N-acetylgalactosamine (GalNAc) with or without N-acetylneuraminic acid (NeuAc).	N-Acetylneuraminic Acid	210-215	immunoglobulin heavy constant alpha 1	Homo sapiens	73-77
24918438-3	2014	Specifically, serum IgA1 of healthy controls has more alpha2,3-sialylated O-glycans (NeuAc attached to Gal) than alpha2,6-sialylated O-glycans (NeuAc attached to GalNAc).	N-Acetylneuraminic Acid	85-90	immunoglobulin heavy constant alpha 1	Homo sapiens	20-24
24918438-3	2014	Specifically, serum IgA1 of healthy controls has more alpha2,3-sialylated O-glycans (NeuAc attached to Gal) than alpha2,6-sialylated O-glycans (NeuAc attached to GalNAc).	N-Acetylneuraminic Acid	144-149	immunoglobulin heavy constant alpha 1	Homo sapiens	20-24
24918438-5	2014	Distribution of NeuAc in IgA1 O-glycans may play an important role in the pathogenesis of IgAN.	N-Acetylneuraminic Acid	16-21	IGAN1	Homo sapiens	90-94
24918438-6	2014	To better understand biological functions of NeuAc in IgA1, we established protocols for enzymatic sialylation leading to alpha2,3- or alpha2,6-sialylation of IgA1 O-glycans.	N-Acetylneuraminic Acid	45-50	immunoglobulin heavy constant alpha 1	Homo sapiens	54-58
24918438-6	2014	To better understand biological functions of NeuAc in IgA1, we established protocols for enzymatic sialylation leading to alpha2,3- or alpha2,6-sialylation of IgA1 O-glycans.	N-Acetylneuraminic Acid	45-50	immunoglobulin heavy constant alpha 1	Homo sapiens	159-163
25166301-5	2014	The gene conversions between CD33-related Siglec genes only occur between similar genes and equally frequently in sialic acid binding and nonbinding domains.	N-Acetylneuraminic Acid	114-125	CD33 molecule	Homo sapiens	29-33
24799499-2	2014	We recently showed that the GBS beta-protein attenuates innate immune responses by binding to sialic acid-binding immunoglobulin-like lectin 5 (Siglec-5), an inhibitory receptor on phagocytes.	N-Acetylneuraminic Acid	94-105	sialic acid binding Ig like lectin 5	Homo sapiens	144-152
24843130-0	2014	PILRalpha and PILRbeta have a siglec fold and provide the basis of binding to sialic acid.	N-Acetylneuraminic Acid	78-89	paired immunoglobin like type 2 receptor alpha	Homo sapiens	0-9
24843130-0	2014	PILRalpha and PILRbeta have a siglec fold and provide the basis of binding to sialic acid.	N-Acetylneuraminic Acid	78-89	paired immunoglobin like type 2 receptor beta	Homo sapiens	14-22
24843130-2	2014	Despite their high sequence identity, PILRalpha and PILRbeta are shown to have variant sialic acid (SA) binding avidities.	N-Acetylneuraminic Acid	87-98	paired immunoglobin like type 2 receptor alpha	Homo sapiens	38-47
24843130-2	2014	Despite their high sequence identity, PILRalpha and PILRbeta are shown to have variant sialic acid (SA) binding avidities.	N-Acetylneuraminic Acid	87-98	paired immunoglobin like type 2 receptor beta	Homo sapiens	52-60
24843130-2	2014	Despite their high sequence identity, PILRalpha and PILRbeta are shown to have variant sialic acid (SA) binding avidities.	N-Acetylneuraminic Acid	100-102	paired immunoglobin like type 2 receptor alpha	Homo sapiens	38-47
24843130-2	2014	Despite their high sequence identity, PILRalpha and PILRbeta are shown to have variant sialic acid (SA) binding avidities.	N-Acetylneuraminic Acid	100-102	paired immunoglobin like type 2 receptor beta	Homo sapiens	52-60
24843130-6	2014	Deploying site-directed mutagenesis, we demonstrated that three residues (Y2, R95, and W108) presented on the surface of PILRalpha form the SA binding site equivalent to those in siglecs but are arranged in a unique linear mode.	N-Acetylneuraminic Acid	140-142	paired immunoglobin like type 2 receptor alpha	Homo sapiens	121-130
24843130-9	2014	We further solved the structure of this PILRbeta mutant complexed with SA, which reveals the atomic details mediating PILR/SA recognition.	N-Acetylneuraminic Acid	71-73	paired immunoglobin like type 2 receptor beta	Homo sapiens	40-48
24921038-0	2014	Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas.	N-Acetylneuraminic Acid	14-25	CD33 molecule	Homo sapiens	52-56
24921038-0	2014	Disubstituted Sialic Acid Ligands Targeting Siglecs CD33 and CD22 Associated with Myeloid Leukaemias and B Cell Lymphomas.	N-Acetylneuraminic Acid	14-25	CD22 molecule	Homo sapiens	61-65
24790146-5	2014	However, Siglec-G has a different ligand sialic acid-binding pattern on peritoneal B1 cells than on splenic B cells, and its sialic acid ligands are expressed differentially on these two B cell populations, suggesting that cis-ligand binding plays a crucial role on B1 cells.	N-Acetylneuraminic Acid	41-52	sialic acid binding Ig-like lectin G	Mus musculus	9-17
24999313-7	2014	Enzyme assays revealed that these mAbs recognized a sialic acid-dependent epitope on CD43.	N-Acetylneuraminic Acid	52-63	sialophorin	Homo sapiens	85-89
24355574-1	2014	Human erythropoietin produced in the egg white of chimeric chicken contains N-glycan with lower amounts of terminal galactose and sialic acid; therefore, the chicken galactosyltransferase gene was introduced together with the human erythropoietin gene by a retroviral vector.	N-Acetylneuraminic Acid	130-141	erythropoietin	Homo sapiens	6-20
24790146-5	2014	However, Siglec-G has a different ligand sialic acid-binding pattern on peritoneal B1 cells than on splenic B cells, and its sialic acid ligands are expressed differentially on these two B cell populations, suggesting that cis-ligand binding plays a crucial role on B1 cells.	N-Acetylneuraminic Acid	125-136	sialic acid binding Ig-like lectin G	Mus musculus	9-17
24790146-10	2014	Thus, Siglec-G sialic acid-dependent binding to the BCR is crucial for the B1 cell-restricted inhibitory function of Siglec-G and is regulated in an opposite way to that of the related protein CD22 (Siglec-2) on B cells.	N-Acetylneuraminic Acid	15-26	sialic acid binding Ig-like lectin G	Mus musculus	6-14
24790146-10	2014	Thus, Siglec-G sialic acid-dependent binding to the BCR is crucial for the B1 cell-restricted inhibitory function of Siglec-G and is regulated in an opposite way to that of the related protein CD22 (Siglec-2) on B cells.	N-Acetylneuraminic Acid	15-26	sialic acid binding Ig-like lectin G	Mus musculus	117-125
24790146-10	2014	Thus, Siglec-G sialic acid-dependent binding to the BCR is crucial for the B1 cell-restricted inhibitory function of Siglec-G and is regulated in an opposite way to that of the related protein CD22 (Siglec-2) on B cells.	N-Acetylneuraminic Acid	15-26	CD22 antigen	Mus musculus	193-197
24790146-10	2014	Thus, Siglec-G sialic acid-dependent binding to the BCR is crucial for the B1 cell-restricted inhibitory function of Siglec-G and is regulated in an opposite way to that of the related protein CD22 (Siglec-2) on B cells.	N-Acetylneuraminic Acid	15-26	CD22 antigen	Mus musculus	199-207
24683186-2	2014	SiglecH is a sialic acid-binding Ig-like lectin that has an immunomodulatory role during viral infections.	N-Acetylneuraminic Acid	13-24	sialic acid binding Ig-like lectin H	Mus musculus	0-7
24648448-4	2014	Surprisingly, HPyV9 VP1 preferentially binds sialyllactosamine compounds terminating in 5-N-glycolyl neuraminic acid (Neu5Gc) over those terminating in 5-N-acetyl neuraminic acid (Neu5Ac), whereas LPyV does not exhibit such a preference.	N-Acetylneuraminic Acid	152-178	VP1	Human polyomavirus 9	20-23
24648448-4	2014	Surprisingly, HPyV9 VP1 preferentially binds sialyllactosamine compounds terminating in 5-N-glycolyl neuraminic acid (Neu5Gc) over those terminating in 5-N-acetyl neuraminic acid (Neu5Ac), whereas LPyV does not exhibit such a preference.	N-Acetylneuraminic Acid	180-186	VP1	Human polyomavirus 9	20-23
24817730-6	2014	The enzyme N-acetylmannosamine-6-phosphate 2-epimerase is involved in the catabolism of sialic acid; specifically, the enzyme converts N-acetylmannosamine-6-phosphate into N-acetylglucosamine-6-phosphate.	N-Acetylneuraminic Acid	88-99	AT695_RS02205	Staphylococcus aureus	11-54
24674885-2	2014	One possible approach is the bispecific T-cell-engaging (BiTE, a registered trademark of Amgen) antibody AMG 330 with dual specificity for CD3 and the sialic acid-binding lectin CD33 (SIGLEC-3), which is frequently expressed on the surface of AML blasts and leukemic stem cells.	N-Acetylneuraminic Acid	151-162	CD33 molecule	Homo sapiens	178-182
24674885-2	2014	One possible approach is the bispecific T-cell-engaging (BiTE, a registered trademark of Amgen) antibody AMG 330 with dual specificity for CD3 and the sialic acid-binding lectin CD33 (SIGLEC-3), which is frequently expressed on the surface of AML blasts and leukemic stem cells.	N-Acetylneuraminic Acid	151-162	CD33 molecule	Homo sapiens	184-192
24382335-4	2014	When expressed as a recombinant protein fused to the Fc region of human IgG1, porcine Siglec-5 was able to bind porcine red blood cells in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	141-152	sialic acid binding Ig like lectin 5	Homo sapiens	86-94
24815175-2	2014	CD33-related sialic acid-binding immunoglobulin-like lectins (Siglecs) belong to the immunoglobulin superfamily and contain a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) that is able to inhibit cytokine production.	N-Acetylneuraminic Acid	13-24	sialic acid-binding Ig-like lectin 5	Sus scrofa	0-4
24678018-7	2014	We also observed that sialic acid content was a major factor for pI shifts between L-PGDS proteoforms.	N-Acetylneuraminic Acid	22-33	prostaglandin D2 synthase	Homo sapiens	83-89
24685176-3	2014	Abeta oligomers bound strongly to GM1 ganglioside, and blocking the sialic acid residue on GM1 decreased oligomer-mediated LTP impairment in mouse hippocampal slices.	N-Acetylneuraminic Acid	68-79	histocompatibility 2, class II antigen A, beta 1	Mus musculus	0-5
24521460-1	2014	N-Acetylneuraminic acid lyase (NAL) is a Class I aldolase that catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac).	N-Acetylneuraminic Acid	163-174	N-acetylneuraminate pyruvate lyase	Homo sapiens	0-29
24521460-1	2014	N-Acetylneuraminic acid lyase (NAL) is a Class I aldolase that catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac).	N-Acetylneuraminic Acid	163-174	N-acetylneuraminate pyruvate lyase	Homo sapiens	31-34
24521460-1	2014	N-Acetylneuraminic acid lyase (NAL) is a Class I aldolase that catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac).	N-Acetylneuraminic Acid	175-198	N-acetylneuraminate pyruvate lyase	Homo sapiens	0-29
24521460-1	2014	N-Acetylneuraminic acid lyase (NAL) is a Class I aldolase that catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac).	N-Acetylneuraminic Acid	175-198	N-acetylneuraminate pyruvate lyase	Homo sapiens	31-34
24521460-1	2014	N-Acetylneuraminic acid lyase (NAL) is a Class I aldolase that catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac).	N-Acetylneuraminic Acid	200-206	N-acetylneuraminate pyruvate lyase	Homo sapiens	0-29
24521460-1	2014	N-Acetylneuraminic acid lyase (NAL) is a Class I aldolase that catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac).	N-Acetylneuraminic Acid	200-206	N-acetylneuraminate pyruvate lyase	Homo sapiens	31-34
24521460-6	2014	In order to address, this we crystallized a Y137A variant of the E. coli NAL in the presence of Neu5Ac.	N-Acetylneuraminic Acid	96-102	N-acetylneuraminate pyruvate lyase	Homo sapiens	73-76
24685176-3	2014	Abeta oligomers bound strongly to GM1 ganglioside, and blocking the sialic acid residue on GM1 decreased oligomer-mediated LTP impairment in mouse hippocampal slices.	N-Acetylneuraminic Acid	68-79	coenzyme Q10A	Mus musculus	91-94
24486207-4	2014	We found that particularly SALP PEP 19-2.5 shows high binding affinities for the influenza virus receptor molecule, N-Acetylneuraminic acid, leading to impaired viral attachment and cellular entry.	N-Acetylneuraminic Acid	116-139	prolyl endopeptidase	Mus musculus	32-35
24600033-1	2014	Siglec-G is a member of the sialic acid-binding Ig-like lectin (Siglec) family expressed on all B cells.	N-Acetylneuraminic Acid	28-39	sialic acid binding Ig-like lectin G	Mus musculus	0-8
24569453-2	2014	The sialic acid-binding Ig-like lectins Siglec-7 and -9 are MHC class I-independent inhibitory receptors on human NK cells that recognize sialic acid-containing carbohydrates.	N-Acetylneuraminic Acid	4-15	sialic acid binding Ig like lectin 7	Homo sapiens	40-55
24569453-2	2014	The sialic acid-binding Ig-like lectins Siglec-7 and -9 are MHC class I-independent inhibitory receptors on human NK cells that recognize sialic acid-containing carbohydrates.	N-Acetylneuraminic Acid	138-149	sialic acid binding Ig like lectin 7	Homo sapiens	40-55
24136589-1	2014	BACKGROUND: UDP-GlcNAc 2-epimerase/ManNAc 6-kinase (GNE) is a bifunctional enzyme responsible for the first committed steps in the synthesis of sialic acid, a common terminal monosaccharide in both protein and lipid glycosylation.	N-Acetylneuraminic Acid	144-155	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	52-55
24550397-6	2014	We report that thrombin-activated platelets, at physiologic concentration and pH, can efficiently and effectively substitute for CMP-sialic acid in extracellular ST6Gal-1-mediated sialylation of target cell surfaces.	N-Acetylneuraminic Acid	133-144	coagulation factor II, thrombin	Homo sapiens	15-23
24550397-6	2014	We report that thrombin-activated platelets, at physiologic concentration and pH, can efficiently and effectively substitute for CMP-sialic acid in extracellular ST6Gal-1-mediated sialylation of target cell surfaces.	N-Acetylneuraminic Acid	133-144	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	162-170
24550397-7	2014	Activated platelets can also supply the sialic acid donor to sialylate the synthetic acceptor, Gal(beta1,4)GlcNAcalpha-o-benzyl, with the product Sia(alpha2,6)Gal(beta1,4)GlcNAcalpha-o-benzyl structurally confirmed by LC/MS.	N-Acetylneuraminic Acid	40-51	galanin and GMAP prepropeptide	Homo sapiens	95-118
24550397-7	2014	Activated platelets can also supply the sialic acid donor to sialylate the synthetic acceptor, Gal(beta1,4)GlcNAcalpha-o-benzyl, with the product Sia(alpha2,6)Gal(beta1,4)GlcNAcalpha-o-benzyl structurally confirmed by LC/MS.	N-Acetylneuraminic Acid	40-51	galanin and GMAP prepropeptide	Homo sapiens	159-182
24729889-5	2014	ALX exposure elevated the blood glucose, plasma advanced oxidation product (AOPP), sialic acid demonstrating disturbed antioxidant status.CE at a dose of 100 mg/kg body weight restored/minimised these alterations towards normal values.	N-Acetylneuraminic Acid	83-94	formyl peptide receptor 2-like	Rattus norvegicus	0-3
24136589-3	2014	The connection between the impairment of sialic acid synthesis and muscle pathology in GNE myopathy remains poorly understood.	N-Acetylneuraminic Acid	41-52	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	87-90
24136589-6	2014	Treatment of GNE myopathy fibroblasts with N-acetylmannosamine (ManNAc), a sialic acid precursor downstream of GNE epimerase activity, ameliorated the increased total GSL concentrations.	N-Acetylneuraminic Acid	75-86	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	13-16
24136589-8	2014	ManNAc supplementation results in decrease of GSL levels, linking abnormal increase of total GSLs in GNE myopathy to defects in the sialic acid biosynthetic pathway.	N-Acetylneuraminic Acid	132-143	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	101-104
24529377-4	2014	Vessels within anti-VEGF-sensitive tumors exhibited high levels of alpha2-6-linked sialic acid, which prevented Gal1 binding.	N-Acetylneuraminic Acid	83-94	immunoglobulin binding protein 1	Homo sapiens	67-75
24388574-3	2014	A potential hypoglycosylation of platelet proteins in these patients might explain this increased reactivity, as removal of sialic acid from platelets, particularly of GPIbalpha, leads to enhance platelet aggregation and clearance from the circulation.	N-Acetylneuraminic Acid	124-135	glycoprotein Ib platelet subunit alpha	Homo sapiens	168-177
24388574-5	2014	RCA120 lectin binding to the platelet membrane of PMM2-CDG patients showed evidence for decreased sialic acid content.	N-Acetylneuraminic Acid	98-109	phosphomannomutase 2	Homo sapiens	50-54
24611049-3	2014	Localized upregulation of a hyposialylated form (lacks sialic acid residues) of Angptl4 secreted by podocytes induces the cardinal morphological and clinical manifestations of human minimal change disease, and is also being increasingly recognized as a significant contributor toward proteinuria in experimental diabetic nephropathy.	N-Acetylneuraminic Acid	55-66	angiopoietin like 4	Homo sapiens	80-87
24553109-5	2014	Ad-hTERT-E1a-HN also effectively and selectively decreased the sialic acid level on EC-109 cells, but not on L02 cells.	N-Acetylneuraminic Acid	63-74	telomerase reverse transcriptase	Homo sapiens	3-8
24529377-4	2014	Vessels within anti-VEGF-sensitive tumors exhibited high levels of alpha2-6-linked sialic acid, which prevented Gal1 binding.	N-Acetylneuraminic Acid	83-94	galectin 1	Homo sapiens	112-116
24529377-6	2014	Interruption of beta1-6GlcNAc branching in ECs or silencing of tumor-derived Gal1 converted refractory into anti-VEGF-sensitive tumors, whereas elimination of alpha2-6-linked sialic acid conferred resistance to anti-VEGF.	N-Acetylneuraminic Acid	175-186	immunoglobulin binding protein 1	Homo sapiens	159-167
23999868-1	2014	The ganglioside GM4 is a sialic acid-containing glycosphingolipid mainly expressed in mammalian brain and erythrocytes.	N-Acetylneuraminic Acid	25-36	T cell receptor alpha variable 6-3	Mus musculus	16-19
24333461-5	2014	Altered expression patterns in st3gal3, neu1, and neu3, which have roles in the sialic acid biosynthesis pathway, correlated with reduced sialic acid content of the glycoprotein by NaBu.	N-Acetylneuraminic Acid	80-91	CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase	Cricetulus griseus	31-38
24333461-5	2014	Altered expression patterns in st3gal3, neu1, and neu3, which have roles in the sialic acid biosynthesis pathway, correlated with reduced sialic acid content of the glycoprotein by NaBu.	N-Acetylneuraminic Acid	80-91	sialidase-1	Cricetulus griseus	40-44
24333461-5	2014	Altered expression patterns in st3gal3, neu1, and neu3, which have roles in the sialic acid biosynthesis pathway, correlated with reduced sialic acid content of the glycoprotein by NaBu.	N-Acetylneuraminic Acid	80-91	sialidase-3	Cricetulus griseus	50-54
24333461-5	2014	Altered expression patterns in st3gal3, neu1, and neu3, which have roles in the sialic acid biosynthesis pathway, correlated with reduced sialic acid content of the glycoprotein by NaBu.	N-Acetylneuraminic Acid	138-149	CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase	Cricetulus griseus	31-38
24333461-5	2014	Altered expression patterns in st3gal3, neu1, and neu3, which have roles in the sialic acid biosynthesis pathway, correlated with reduced sialic acid content of the glycoprotein by NaBu.	N-Acetylneuraminic Acid	138-149	sialidase-1	Cricetulus griseus	40-44
24333461-5	2014	Altered expression patterns in st3gal3, neu1, and neu3, which have roles in the sialic acid biosynthesis pathway, correlated with reduced sialic acid content of the glycoprotein by NaBu.	N-Acetylneuraminic Acid	138-149	sialidase-3	Cricetulus griseus	50-54
24161415-6	2014	Furthermore, we showed that the protein-lymphocyte interaction occurred via the pathogen-recognition domain of ficolin-1 to sialic acid on the cell surface.	N-Acetylneuraminic Acid	124-135	ficolin 1	Homo sapiens	111-120
24696692-3	2014	Sialic acid carried by fibronectin as the antigen of the monoclonal antibody (MoAb) JT-95, was detected in 90% of papillary thyroid carcinoma cases, and in a few follicular thyroid carcinomas, in the extracellular matrix of thyroid carcinoma cells.	N-Acetylneuraminic Acid	0-11	fibronectin 1	Homo sapiens	23-34
23530732-7	2014	Probesets for SMAD 7 (SMA- and MAD-related protein 7) and SIGLECP3 (sialic acid-binding immunoglobulin-like lectin, pseudogene 3) were the most significant differentially expressed genes following FDR correction, and both were down-regulated in individuals who responded to treatment.	N-Acetylneuraminic Acid	68-79	SMAD family member 7	Homo sapiens	14-20
23530732-7	2014	Probesets for SMAD 7 (SMA- and MAD-related protein 7) and SIGLECP3 (sialic acid-binding immunoglobulin-like lectin, pseudogene 3) were the most significant differentially expressed genes following FDR correction, and both were down-regulated in individuals who responded to treatment.	N-Acetylneuraminic Acid	68-79	survival of motor neuron 1, telomeric	Homo sapiens	22-52
23530732-7	2014	Probesets for SMAD 7 (SMA- and MAD-related protein 7) and SIGLECP3 (sialic acid-binding immunoglobulin-like lectin, pseudogene 3) were the most significant differentially expressed genes following FDR correction, and both were down-regulated in individuals who responded to treatment.	N-Acetylneuraminic Acid	68-79	sialic acid binding Ig like lectin 17, pseudogene	Homo sapiens	58-66
24131142-7	2014	The lectin CD22, a member of the Siglec family, binds sialic acid-containing glycoconjugates found on host tissues, inhibiting BCR signaling to prevent erroneous B cell activation.	N-Acetylneuraminic Acid	54-65	CD22 molecule	Homo sapiens	11-15
24131142-7	2014	The lectin CD22, a member of the Siglec family, binds sialic acid-containing glycoconjugates found on host tissues, inhibiting BCR signaling to prevent erroneous B cell activation.	N-Acetylneuraminic Acid	54-65	BCR activator of RhoGEF and GTPase	Homo sapiens	127-130
24026681-6	2014	The ST3GAL5 enzyme synthesizes ganglioside GM3, a glycosophingolipid enriched in neural tissue, by adding sialic acid to lactosylceramide.	N-Acetylneuraminic Acid	106-117	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Danio rerio	4-11
24214979-9	2014	These experiments define a candidate site on CR1 by which P. falciparum merozoites gain access to human erythrocytes in a non-sialic acid-dependent pathway of merozoite invasion.	N-Acetylneuraminic Acid	126-137	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	45-48
25230235-1	2014	GNE (UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase) is a bifunctional enzyme which catalyzes the conversion of UDP-GlcNAc to ManNAc and ManNAc to ManNAc 6-phosphate, key steps in the sialic acid biosynthesis.	N-Acetylneuraminic Acid	200-211	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	0-3
25163170-1	2014	Zanamivir and Oseltamivir are both sialic acid analog inhibitors of Neuraminidase (NA), which is an important target in influenza A virus treatment.	N-Acetylneuraminic Acid	35-46	neuraminidase 1	Homo sapiens	68-81
24643041-2	2014	It has been recognized for some time that avian influenza viruses usually bind to terminal sialic acid that is linked in the alpha2-3 configuration to the next sugar while human viruses show preference for alpha2-6 linked sialic acid.	N-Acetylneuraminic Acid	222-233	immunoglobulin binding protein 1	Homo sapiens	206-214
24173532-0	2014	Downregulation of Hsp70 inhibits apoptosis induced by sialic acid-binding lectin (leczyme).	N-Acetylneuraminic Acid	54-65	heat shock protein 1B	Mus musculus	18-23
23900835-0	2014	Infantile Sialic Acid Storage Disease: Two Unrelated Inuit Cases Homozygous for a Common Novel SLC17A5 Mutation.	N-Acetylneuraminic Acid	10-21	solute carrier family 17 member 5	Homo sapiens	95-102
24484550-1	2014	Sialic acid is a carbohydrate moiety of k-casein glycomacropeptide (GMP), which is a 64 amino acid residue C-terminal sialylated phosphorylated glycopeptide released from k-casein by the action of chymosin during cheese making.	N-Acetylneuraminic Acid	0-11	chymosin	Bos taurus	197-205
24903765-1	2014	BACKGROUND: Vascular adhesion protein-1 (VAP-1) is a glycoprotein that mediates tissue-selective lymphocyte adhesion in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	122-133	amine oxidase copper containing 3	Homo sapiens	12-39
24903765-1	2014	BACKGROUND: Vascular adhesion protein-1 (VAP-1) is a glycoprotein that mediates tissue-selective lymphocyte adhesion in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	122-133	amine oxidase copper containing 3	Homo sapiens	41-46
24330394-1	2013	BACKGROUND: Sialic acid-binding Ig-like lectin-7 (Siglec-7) expression is strongly reduced on natural killer (NK) cells from HIV-1 infected viremic patients.	N-Acetylneuraminic Acid	12-23	sialic acid binding Ig like lectin 7	Homo sapiens	50-58
24330394-3	2013	RESULTS: The ability of Siglec-7 to bind gp120 Env in a sialic acid-dependent manner facilitates the infection of both T cells and monocyte-derived macrophages (MDMs).	N-Acetylneuraminic Acid	56-67	sialic acid binding Ig like lectin 7	Homo sapiens	24-32
24330394-3	2013	RESULTS: The ability of Siglec-7 to bind gp120 Env in a sialic acid-dependent manner facilitates the infection of both T cells and monocyte-derived macrophages (MDMs).	N-Acetylneuraminic Acid	56-67	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	41-46
24337294-6	2013	This homogeneous erythropoietin glycosylated at the three wild-type aspartates with N-linked high-mannose sialic acid-containing oligosaccharides and O-linked glycophorin exhibits Procrit-level in vivo activity in mice.	N-Acetylneuraminic Acid	106-117	erythropoietin	Mus musculus	17-31
24349002-3	2013	The key enzyme of sialic acid biosynthesis is the bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE), which catalyses the first two steps of Sia biosynthesis in the cytosol.	N-Acetylneuraminic Acid	18-29	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	127-130
24330394-3	2013	RESULTS: The ability of Siglec-7 to bind gp120 Env in a sialic acid-dependent manner facilitates the infection of both T cells and monocyte-derived macrophages (MDMs).	N-Acetylneuraminic Acid	56-67	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	47-50
24227736-2	2013	Siglec-E is a mouse CD33-related Siglec that preferentially binds to sialic acid residues of the cellular glycocalyx.	N-Acetylneuraminic Acid	69-80	sialic acid binding Ig-like lectin E	Mus musculus	0-8
24155237-6	2013	The resulting structure revealed an overall protein fold broadly resembling the previously determined structure of pig ST3GAL1, including a CMP-sialic acid-binding site assembled from conserved sialylmotif sequence elements.	N-Acetylneuraminic Acid	144-155	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Sus scrofa	119-126
24145038-0	2013	Binding of a sialic acid-recognizing lectin Siglec-9 modulates adhesion dynamics of cancer cells via calpain-mediated protein degradation.	N-Acetylneuraminic Acid	13-24	sialic acid binding Ig like lectin 9	Homo sapiens	44-52
24227736-2	2013	Siglec-E is a mouse CD33-related Siglec that preferentially binds to sialic acid residues of the cellular glycocalyx.	N-Acetylneuraminic Acid	69-80	CD33 antigen	Mus musculus	20-24
24227736-6	2013	Coculture of mouse microglia and neurons demonstrated a neuroprotective effect of microglial Siglec-E that was dependent on neuronal sialic acid residues.	N-Acetylneuraminic Acid	133-144	sialic acid binding Ig-like lectin E	Mus musculus	93-101
23919962-5	2013	This interplay was correlated with decreased sialic acid levels on the beta-chain of the IR and reduction of IR signaling.	N-Acetylneuraminic Acid	45-56	insulin receptor	Mus musculus	89-91
23988663-0	2013	alpha2-3 Sialic acid glycoconjugate loss and its effect on infection with Toxoplasma parasites.	N-Acetylneuraminic Acid	9-20	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	0-8
23720238-6	2013	We observed that the removal with neuraminidase of the sialic acid moieties from the different EPOs studied reduced their apparent molecular weight (MW) and increased the migration distance between huEPO and rhEPO centroids, therefore eliminating the size overlaps between them and improving the detection of rhEPO.	N-Acetylneuraminic Acid	55-66	neuraminidase 1	Homo sapiens	34-47
23988663-4	2013	Here, we focused on the role of alpha2-3 sialic acid linkages as they appear to be widely expressed in vertebrates.	N-Acetylneuraminic Acid	41-52	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	32-40
23988663-5	2013	Removal of alpha2-3 sialic acid linkages on macrophages by neuraminidase treatment did not influence the rate of infection or growth of T. gondii, nor did it affect phagocytosis in vitro.	N-Acetylneuraminic Acid	20-31	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	11-19
23988663-6	2013	Sialyltransferase ST3Gal-I deficient mice (ST3Gal-I(-/-) mice) lost alpha2-3 sialic acid linkages in macrophages and spleen cells.	N-Acetylneuraminic Acid	77-88	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Mus musculus	18-26
23988663-6	2013	Sialyltransferase ST3Gal-I deficient mice (ST3Gal-I(-/-) mice) lost alpha2-3 sialic acid linkages in macrophages and spleen cells.	N-Acetylneuraminic Acid	77-88	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Mus musculus	43-51
23988663-6	2013	Sialyltransferase ST3Gal-I deficient mice (ST3Gal-I(-/-) mice) lost alpha2-3 sialic acid linkages in macrophages and spleen cells.	N-Acetylneuraminic Acid	77-88	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	68-76
23988663-11	2013	Our data show that parasite invasion via alpha2-3 sialic acid linkages might not contribute on host survival and indicate the impact that loss of alpha2-3 sialic acid linkages has on CD8(+) T cell populations, which are necessary for effective immune responses against infection with T. gondii.	N-Acetylneuraminic Acid	155-166	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	146-154
24045940-0	2013	Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of beta-catenin and subsequent cell growth.	N-Acetylneuraminic Acid	15-26	sialic acid binding Ig like lectin 9	Homo sapiens	43-51
24045940-0	2013	Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of beta-catenin and subsequent cell growth.	N-Acetylneuraminic Acid	15-26	LOC100508689	Homo sapiens	69-74
24045940-0	2013	Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of beta-catenin and subsequent cell growth.	N-Acetylneuraminic Acid	15-26	mucin 1, cell surface associated	Homo sapiens	76-80
24045940-0	2013	Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of beta-catenin and subsequent cell growth.	N-Acetylneuraminic Acid	15-26	catenin beta 1	Homo sapiens	105-117
23970553-2	2013	The channel is glycosylated with a complex type N-glycan and it has been postulated that hydrolysis of the terminal sialic acid(s) stimulate TRPV5 activity.	N-Acetylneuraminic Acid	116-127	transient receptor potential cation channel subfamily V member 5	Homo sapiens	141-146
24074599-1	2013	Human influenza viruses predominantly bind alpha2,6 linked sialic acid (SA) while avian viruses bind alpha2,3 SA-containing complex glycans.	N-Acetylneuraminic Acid	110-112	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	101-109
24074599-6	2013	There is increasing evidence that receptor specificity of influenza viruses is more complex than the binary model of alpha2,6 and alpha2,3 SA binding and our data suggest that influenza viruses use a wide range of SA moieties to infect host cells.	N-Acetylneuraminic Acid	139-141	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	130-138
24129184-1	2013	The bi-functional enzyme UDP-N-acetyl-2-epimerase/N-acetylmannosamine kinase (GNE) is the key enzyme of the sialic acid biosynthesis.	N-Acetylneuraminic Acid	108-119	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	78-81
24204874-11	2013	We propose that the sialyl motif of Tc Muc is able to interact with sialic acid-binding Ig-like lectins (Siglecs) on CD4(+) T cells, which may allow the parasite to modulate the immune system.	N-Acetylneuraminic Acid	68-79	CD4 antigen	Mus musculus	117-120
24285971-1	2013	BACKGROUND: GNE myopathy is characterized by early-adult-onset distal myopathy sparing quadriceps caused by mutations in the GNE gene encoding UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, an enzyme in the sialic-acid synthesis pathway.	N-Acetylneuraminic Acid	224-235	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	125-128
23519914-2	2013	Following the treatment of different concentrations of alpha2,3-neuraminidase, which specifically removed the alpha2-3 sialic acid from cell surface, a significant decrease of alpha2-3 sialic acid was detected with fluorescein isothiocyanate (FITC)-labeled Maackia amurensis lectin (MAL-II) by flow cytometry analysis.	N-Acetylneuraminic Acid	119-130	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	110-118
23519914-2	2013	Following the treatment of different concentrations of alpha2,3-neuraminidase, which specifically removed the alpha2-3 sialic acid from cell surface, a significant decrease of alpha2-3 sialic acid was detected with fluorescein isothiocyanate (FITC)-labeled Maackia amurensis lectin (MAL-II) by flow cytometry analysis.	N-Acetylneuraminic Acid	119-130	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	176-184
23519914-6	2013	Both RT-PCR and Western blot analysis demonstrated that the expression of bone sialoprotein (BSP), osteoprotegerin (OPG), and vitamin D receptor (VDR) were significantly decreased when alpha2-3 sialic acid expression decreased on the cell surface, while the expression of osteocalcin (OC) and osteopontin (OPN) remained unchanged.	N-Acetylneuraminic Acid	194-205	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	99-114
23519914-6	2013	Both RT-PCR and Western blot analysis demonstrated that the expression of bone sialoprotein (BSP), osteoprotegerin (OPG), and vitamin D receptor (VDR) were significantly decreased when alpha2-3 sialic acid expression decreased on the cell surface, while the expression of osteocalcin (OC) and osteopontin (OPN) remained unchanged.	N-Acetylneuraminic Acid	194-205	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	116-119
23519914-6	2013	Both RT-PCR and Western blot analysis demonstrated that the expression of bone sialoprotein (BSP), osteoprotegerin (OPG), and vitamin D receptor (VDR) were significantly decreased when alpha2-3 sialic acid expression decreased on the cell surface, while the expression of osteocalcin (OC) and osteopontin (OPN) remained unchanged.	N-Acetylneuraminic Acid	194-205	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	126-144
23519914-6	2013	Both RT-PCR and Western blot analysis demonstrated that the expression of bone sialoprotein (BSP), osteoprotegerin (OPG), and vitamin D receptor (VDR) were significantly decreased when alpha2-3 sialic acid expression decreased on the cell surface, while the expression of osteocalcin (OC) and osteopontin (OPN) remained unchanged.	N-Acetylneuraminic Acid	194-205	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	146-149
23519914-6	2013	Both RT-PCR and Western blot analysis demonstrated that the expression of bone sialoprotein (BSP), osteoprotegerin (OPG), and vitamin D receptor (VDR) were significantly decreased when alpha2-3 sialic acid expression decreased on the cell surface, while the expression of osteocalcin (OC) and osteopontin (OPN) remained unchanged.	N-Acetylneuraminic Acid	194-205	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	185-193
23519914-6	2013	Both RT-PCR and Western blot analysis demonstrated that the expression of bone sialoprotein (BSP), osteoprotegerin (OPG), and vitamin D receptor (VDR) were significantly decreased when alpha2-3 sialic acid expression decreased on the cell surface, while the expression of osteocalcin (OC) and osteopontin (OPN) remained unchanged.	N-Acetylneuraminic Acid	194-205	bone gamma-carboxyglutamate protein 2	Mus musculus	272-283
23519914-6	2013	Both RT-PCR and Western blot analysis demonstrated that the expression of bone sialoprotein (BSP), osteoprotegerin (OPG), and vitamin D receptor (VDR) were significantly decreased when alpha2-3 sialic acid expression decreased on the cell surface, while the expression of osteocalcin (OC) and osteopontin (OPN) remained unchanged.	N-Acetylneuraminic Acid	194-205	bone gamma-carboxyglutamate protein 2	Mus musculus	285-287
23519914-6	2013	Both RT-PCR and Western blot analysis demonstrated that the expression of bone sialoprotein (BSP), osteoprotegerin (OPG), and vitamin D receptor (VDR) were significantly decreased when alpha2-3 sialic acid expression decreased on the cell surface, while the expression of osteocalcin (OC) and osteopontin (OPN) remained unchanged.	N-Acetylneuraminic Acid	194-205	secreted phosphoprotein 1	Mus musculus	293-304
23519914-6	2013	Both RT-PCR and Western blot analysis demonstrated that the expression of bone sialoprotein (BSP), osteoprotegerin (OPG), and vitamin D receptor (VDR) were significantly decreased when alpha2-3 sialic acid expression decreased on the cell surface, while the expression of osteocalcin (OC) and osteopontin (OPN) remained unchanged.	N-Acetylneuraminic Acid	194-205	secreted phosphoprotein 1	Mus musculus	306-309
23519914-7	2013	We propose a hypothesis that alpha2-3 sialic acid affects bone mineralization but not osteogenic differentiation.	N-Acetylneuraminic Acid	38-49	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	29-37
23547010-0	2013	A shift from N-glycolyl- to N-acetyl-sialic acid in the GM3 ganglioside impairs tumor development in mouse lymphocytic leukemia cells.	N-Acetylneuraminic Acid	28-48	granulocyte macrophage antigen 3	Mus musculus	56-59
24285971-1	2013	BACKGROUND: GNE myopathy is characterized by early-adult-onset distal myopathy sparing quadriceps caused by mutations in the GNE gene encoding UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, an enzyme in the sialic-acid synthesis pathway.	N-Acetylneuraminic Acid	224-235	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	12-15
24285971-1	2013	BACKGROUND: GNE myopathy is characterized by early-adult-onset distal myopathy sparing quadriceps caused by mutations in the GNE gene encoding UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, an enzyme in the sialic-acid synthesis pathway.	N-Acetylneuraminic Acid	224-235	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	143-205
24285971-4	2013	CONCLUSIONS: This is a representative case implying that an increased requirement of sialic acid during pregnancy might trigger a clinical worsening of GNE myopathy.	N-Acetylneuraminic Acid	85-96	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	152-155
23974695-8	2013	P-3F(ax)-Neu5Ac-treated cancer cells exhibited impaired binding to poly-l-lysine, type I collagen, and fibronectin and diminished migratory capacity.	N-Acetylneuraminic Acid	9-15	fibronectin 1	Mus musculus	82-114
23398317-6	2013	A significant increase in N-acetylgalactosamine (GalNAc) in terminal position (p = 0.02) observed in some of the IgAN patients, became more pronounced when sialic acid was removed from IgA1, indicating enhanced expression of alpha-2,6-sialyltransferase in patients compared with controls (p &lt; 0.0001).	N-Acetylneuraminic Acid	156-167	IGAN1	Homo sapiens	113-117
23740482-1	2013	Porcine sialoadhesin (pSn; a sialic acid-binding lectin) and porcine CD163 (pCD163) are molecules that facilitate infectious entry of porcine reproductive and respiratory syndrome virus (PRRSV) into alveolar macrophages.	N-Acetylneuraminic Acid	29-40	sialic acid binding Ig like lectin 1	Homo sapiens	8-20
23934027-2	2013	The first is by its release from the cell surface of CD4 T cells that express high levels of CD52 that then binds to the inhibitory sialic acid-binding immunoglobulin-like lectins-10 (Siglec-10) receptor to attenuate effector T-cell activation by impairing phosphorylation of T-cell receptor associated lck and zap-70.	N-Acetylneuraminic Acid	132-143	CD52 molecule	Homo sapiens	93-97
23934027-2	2013	The first is by its release from the cell surface of CD4 T cells that express high levels of CD52 that then binds to the inhibitory sialic acid-binding immunoglobulin-like lectins-10 (Siglec-10) receptor to attenuate effector T-cell activation by impairing phosphorylation of T-cell receptor associated lck and zap-70.	N-Acetylneuraminic Acid	132-143	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	311-317
23740482-3	2013	Intact sialic acid-binding domains are crucial, since non-sialic acid-binding mutants of pSn, mSn and hSn did not promote infection.	N-Acetylneuraminic Acid	7-18	moesin	Mus musculus	94-97
23740482-3	2013	Intact sialic acid-binding domains are crucial, since non-sialic acid-binding mutants of pSn, mSn and hSn did not promote infection.	N-Acetylneuraminic Acid	7-18	fascin actin-bundling protein 1	Homo sapiens	102-105
23740482-3	2013	Intact sialic acid-binding domains are crucial, since non-sialic acid-binding mutants of pSn, mSn and hSn did not promote infection.	N-Acetylneuraminic Acid	58-69	moesin	Mus musculus	94-97
23740482-3	2013	Intact sialic acid-binding domains are crucial, since non-sialic acid-binding mutants of pSn, mSn and hSn did not promote infection.	N-Acetylneuraminic Acid	58-69	fascin actin-bundling protein 1	Homo sapiens	102-105
23535562-0	2013	One-pot multi-enzyme (OPME) chemoenzymatic synthesis of sialyl-Tn-MUC1 and sialyl-T-MUC1 glycopeptides containing natural or non-natural sialic acid.	N-Acetylneuraminic Acid	137-148	mucin 1, cell surface associated	Homo sapiens	84-88
23785195-2	2013	In vitro, the attachment and internalization of PRRSV are dependent on the interaction between sialic acid on the virion surface and the sialic acid binding domain of the SIGLEC1 gene.	N-Acetylneuraminic Acid	95-106	sialic acid binding Ig like lectin 1	Sus scrofa	171-178
23785195-2	2013	In vitro, the attachment and internalization of PRRSV are dependent on the interaction between sialic acid on the virion surface and the sialic acid binding domain of the SIGLEC1 gene.	N-Acetylneuraminic Acid	137-148	sialic acid binding Ig like lectin 1	Sus scrofa	171-178
23535562-2	2013	In situ generation of the sialyltransferase donor cytidine 5"-monophosphate-sialic acid (CMP-Sia) using a CMP-sialic acid synthetase in the presence of an extra amount of cytidine 5"-triphosphate (CTP) and removal of CMP from the reaction mixture by flash C18 cartridge purification allow the complete consumption of Tn-MUC1 glycopeptide for quantitative synthesis of STn-MUC1.	N-Acetylneuraminic Acid	76-87	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	106-132
23535562-2	2013	In situ generation of the sialyltransferase donor cytidine 5"-monophosphate-sialic acid (CMP-Sia) using a CMP-sialic acid synthetase in the presence of an extra amount of cytidine 5"-triphosphate (CTP) and removal of CMP from the reaction mixture by flash C18 cartridge purification allow the complete consumption of Tn-MUC1 glycopeptide for quantitative synthesis of STn-MUC1.	N-Acetylneuraminic Acid	76-87	mucin 1, cell surface associated	Homo sapiens	320-324
23535562-2	2013	In situ generation of the sialyltransferase donor cytidine 5"-monophosphate-sialic acid (CMP-Sia) using a CMP-sialic acid synthetase in the presence of an extra amount of cytidine 5"-triphosphate (CTP) and removal of CMP from the reaction mixture by flash C18 cartridge purification allow the complete consumption of Tn-MUC1 glycopeptide for quantitative synthesis of STn-MUC1.	N-Acetylneuraminic Acid	76-87	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	368-371
23535562-2	2013	In situ generation of the sialyltransferase donor cytidine 5"-monophosphate-sialic acid (CMP-Sia) using a CMP-sialic acid synthetase in the presence of an extra amount of cytidine 5"-triphosphate (CTP) and removal of CMP from the reaction mixture by flash C18 cartridge purification allow the complete consumption of Tn-MUC1 glycopeptide for quantitative synthesis of STn-MUC1.	N-Acetylneuraminic Acid	76-87	mucin 1, cell surface associated	Homo sapiens	372-376
23946390-3	2013	Here, we elucidate the mechanism of action of the AD-associated polymorphism rs3865444 in the promoter of CD33, a member of the sialic acid-binding Ig-superfamily of lectins (SIGLECs).	N-Acetylneuraminic Acid	128-139	CD33 molecule	Homo sapiens	106-110
23946390-12	2013	Exon 2 encodes the CD33 IgV domain that typically mediates sialic acid binding in SIGLEC family members.	N-Acetylneuraminic Acid	59-70	CD33 antigen	Mus musculus	19-23
23951351-1	2013	Polysialic acid (polySia), an alpha-2,8-glycosidically linked polymer of sialic acid, is a developmentally regulated post-translational modification predominantly found on NCAM (neuronal cell adhesion molecule).	N-Acetylneuraminic Acid	4-15	neuronal cell adhesion molecule	Homo sapiens	172-176
23873973-3	2013	Functional studies included biochemical assays for N-glycosylation and mucin-type O-glycosylation and SLC35A1-encoded cytidine 5"-monophosphosialic acid (CMP-sialic acid) transport after heterologous expression in yeast.	N-Acetylneuraminic Acid	141-152	solute carrier family 35 member A1	Homo sapiens	102-109
23873973-7	2013	Functional analysis of mutant SLC35A1 showed normal Golgi localization but 50% reduction in transport activity of CMP-sialic acid in vitro.	N-Acetylneuraminic Acid	118-129	solute carrier family 35 member A1	Homo sapiens	30-37
23951351-1	2013	Polysialic acid (polySia), an alpha-2,8-glycosidically linked polymer of sialic acid, is a developmentally regulated post-translational modification predominantly found on NCAM (neuronal cell adhesion molecule).	N-Acetylneuraminic Acid	4-15	neuronal cell adhesion molecule	Homo sapiens	178-209
23935934-2	2013	Osteopontin (OPN) is a secreted non-collagenous, sialic acid rich, chemokine-like phosphoglycoprotein that facilitates cell-matrix interactions and promotes tumor progression.	N-Acetylneuraminic Acid	49-60	secreted phosphoprotein 1	Mus musculus	0-11
23266873-1	2013	The bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) catalyzes the first two committed steps in sialic acid synthesis.	N-Acetylneuraminic Acid	110-121	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	62-65
23750721-7	2013	To date, the removal of sialic acid from fetuin at pH 7.0 was reported only with soluble Neu2 and the membrane fraction from Neu2-transfected COS cells.	N-Acetylneuraminic Acid	24-35	neuraminidase 2	Mus musculus	89-93
23750721-7	2013	To date, the removal of sialic acid from fetuin at pH 7.0 was reported only with soluble Neu2 and the membrane fraction from Neu2-transfected COS cells.	N-Acetylneuraminic Acid	24-35	neuraminidase 2	Mus musculus	125-129
24224085-2	2013	In mammals, the sialic acid of Podocalyxin plays a crucial role in the formation of the characteristic podocyte architecture required for glomerular filtration.	N-Acetylneuraminic Acid	16-27	podocalyxin-like	Danio rerio	31-42
24224085-7	2013	Splice blocking of podocalyxin exon 2, which partially encodes the bulky mucin domain with extensive sialic acid-containing sugar chains, resulted in the deletion of 53% of mucin domain-coding sequence from podocalyxin mRNA.	N-Acetylneuraminic Acid	101-112	podocalyxin-like	Danio rerio	19-30
23935934-2	2013	Osteopontin (OPN) is a secreted non-collagenous, sialic acid rich, chemokine-like phosphoglycoprotein that facilitates cell-matrix interactions and promotes tumor progression.	N-Acetylneuraminic Acid	49-60	secreted phosphoprotein 1	Mus musculus	13-16
23830432-5	2013	In addition, the approach was applied to characterize the sialylated status of alpha2-macroglobulin and transferrin, respectively, from the sera of healthy subjects and sex- and age-matched patients with thyroid cancer, and their spectra indicate that the change in the amount of the glycoforms containing different number of sialic acid (SA) residues from one glycosylation site may be used to differentiate between healthy subjects and cancer cases.	N-Acetylneuraminic Acid	326-337	alpha-2-macroglobulin	Homo sapiens	79-99
23597400-6	2013	In silico docking to the crystal structure of Siglec-7 provides a rationale for the affinity gains observed for this novel sialic acid analogue.	N-Acetylneuraminic Acid	123-134	sialic acid binding Ig like lectin 7	Homo sapiens	46-54
23830432-5	2013	In addition, the approach was applied to characterize the sialylated status of alpha2-macroglobulin and transferrin, respectively, from the sera of healthy subjects and sex- and age-matched patients with thyroid cancer, and their spectra indicate that the change in the amount of the glycoforms containing different number of sialic acid (SA) residues from one glycosylation site may be used to differentiate between healthy subjects and cancer cases.	N-Acetylneuraminic Acid	326-337	transferrin	Homo sapiens	104-115
23830432-5	2013	In addition, the approach was applied to characterize the sialylated status of alpha2-macroglobulin and transferrin, respectively, from the sera of healthy subjects and sex- and age-matched patients with thyroid cancer, and their spectra indicate that the change in the amount of the glycoforms containing different number of sialic acid (SA) residues from one glycosylation site may be used to differentiate between healthy subjects and cancer cases.	N-Acetylneuraminic Acid	339-341	alpha-2-macroglobulin	Homo sapiens	79-99
23830432-5	2013	In addition, the approach was applied to characterize the sialylated status of alpha2-macroglobulin and transferrin, respectively, from the sera of healthy subjects and sex- and age-matched patients with thyroid cancer, and their spectra indicate that the change in the amount of the glycoforms containing different number of sialic acid (SA) residues from one glycosylation site may be used to differentiate between healthy subjects and cancer cases.	N-Acetylneuraminic Acid	339-341	transferrin	Homo sapiens	104-115
23776238-4	2013	We then investigated the effect of N-glycosylation on the function of BCMA and found that the dexamethasone-induced apoptosis in malignant plasma cells can be rescued by treatment with BCMA ligands, such as a proliferation-inducing ligand (APRIL) and B-cell-activating factor (BAFF), whereas removal of terminal sialic acid on plasma cells further potentiated the ligand-mediated protection.	N-Acetylneuraminic Acid	312-323	TNF receptor superfamily member 17	Homo sapiens	70-74
23776238-4	2013	We then investigated the effect of N-glycosylation on the function of BCMA and found that the dexamethasone-induced apoptosis in malignant plasma cells can be rescued by treatment with BCMA ligands, such as a proliferation-inducing ligand (APRIL) and B-cell-activating factor (BAFF), whereas removal of terminal sialic acid on plasma cells further potentiated the ligand-mediated protection.	N-Acetylneuraminic Acid	312-323	TNF receptor superfamily member 17	Homo sapiens	185-189
23776238-4	2013	We then investigated the effect of N-glycosylation on the function of BCMA and found that the dexamethasone-induced apoptosis in malignant plasma cells can be rescued by treatment with BCMA ligands, such as a proliferation-inducing ligand (APRIL) and B-cell-activating factor (BAFF), whereas removal of terminal sialic acid on plasma cells further potentiated the ligand-mediated protection.	N-Acetylneuraminic Acid	312-323	TNF superfamily member 13	Homo sapiens	207-238
23709682-2	2013	Humans have a unique mutation of the enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH), causing loss of expression of the sialic acid Neu5Gc.	N-Acetylneuraminic Acid	126-137	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	44-83
23520133-3	2013	Insulin binding to its receptor rapidly induces interaction of the receptor with Neu1, which hydrolyzes sialic acid residues in the glycan chains of the receptor and, consequently, induces its activation.	N-Acetylneuraminic Acid	104-115	insulin	Homo sapiens	0-7
23520133-3	2013	Insulin binding to its receptor rapidly induces interaction of the receptor with Neu1, which hydrolyzes sialic acid residues in the glycan chains of the receptor and, consequently, induces its activation.	N-Acetylneuraminic Acid	104-115	neuraminidase 1	Homo sapiens	81-85
23514716-7	2013	The CMAH enzyme is active in other mammals, including mice, where Neu5Gc is an abundant form of sialic acid on cellular membranes, including those in cardiac and skeletal muscle.	N-Acetylneuraminic Acid	96-107	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Mus musculus	4-8
23709682-2	2013	Humans have a unique mutation of the enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH), causing loss of expression of the sialic acid Neu5Gc.	N-Acetylneuraminic Acid	126-137	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	85-89
23439307-9	2013	Also, recombinant SasA protein (rSasA) showed binding affinity to gp340, which was inhibited by the addition of N-acetylneuraminic acid.	N-Acetylneuraminic Acid	112-135	deleted in malignant brain tumors 1	Homo sapiens	66-71
23805213-1	2013	It is generally accepted that human influenza viruses bind glycans containing sialic acid linked alpha2-6 to the next sugar, that avian influenza viruses bind glycans containing the alpha2-3 linkage, and that mutations that change the binding specificity might change the host tropism.	N-Acetylneuraminic Acid	78-89	immunoglobulin binding protein 1	Homo sapiens	97-105
23616577-8	2013	Furthermore, the presence of sialic acid in the IgG carbohydrate altered FCRL5 binding.	N-Acetylneuraminic Acid	29-40	Fc receptor like 5	Homo sapiens	73-78
23822217-4	2013	Our laboratory has identified porcine sialoadhesin expressed on Kupffer cells as the lectin responsible for binding N-acetylneuraminic acid on the surface of the hRBC.	N-Acetylneuraminic Acid	116-139	sialic acid binding Ig like lectin 1	Homo sapiens	38-50
23822217-4	2013	Our laboratory has identified porcine sialoadhesin expressed on Kupffer cells as the lectin responsible for binding N-acetylneuraminic acid on the surface of the hRBC.	N-Acetylneuraminic Acid	116-139	RNA, 7SL, cytoplasmic 263, pseudogene	Homo sapiens	162-166
23631694-11	2013	Oxidation of the sialic acid side chains of Tf generated aldehyde functionalized protein that was reacted with aminooxy terminated poly(HPMA), which resulted in protein-polymer bioconjugates carrying oxime linkages.	N-Acetylneuraminic Acid	17-28	transferrin	Homo sapiens	44-46
23439307-11	2013	These results indicate that SasA is responsible for binding to gp340 via the N-acetylneuraminic acid moiety.	N-Acetylneuraminic Acid	77-100	deleted in malignant brain tumors 1	Homo sapiens	63-68
23425865-2	2013	METHODS: Oxygen of the glycoside bond of sialoside was replaced with sulfur to prevent hydrolytic digestion of the N-acetylneuraminic acid residue by viral neuraminidase.	N-Acetylneuraminic Acid	115-138	neuraminidase 1	Homo sapiens	156-169
23741500-1	2013	N-acetylneuraminate pyruvate lyase (NPL) catalyzes N-acetylneuraminic acid, the predominant sialic acid.	N-Acetylneuraminic Acid	51-74	N-acetylneuraminate pyruvate lyase	Mus musculus	0-34
23741500-1	2013	N-acetylneuraminate pyruvate lyase (NPL) catalyzes N-acetylneuraminic acid, the predominant sialic acid.	N-Acetylneuraminic Acid	51-74	N-acetylneuraminate pyruvate lyase	Mus musculus	36-39
23741500-1	2013	N-acetylneuraminate pyruvate lyase (NPL) catalyzes N-acetylneuraminic acid, the predominant sialic acid.	N-Acetylneuraminic Acid	92-103	N-acetylneuraminate pyruvate lyase	Mus musculus	0-34
23741500-1	2013	N-acetylneuraminate pyruvate lyase (NPL) catalyzes N-acetylneuraminic acid, the predominant sialic acid.	N-Acetylneuraminic Acid	92-103	N-acetylneuraminate pyruvate lyase	Mus musculus	36-39
23567969-3	2013	Siglec-9 bound to prohibitins in a sialic acid-independent manner.	N-Acetylneuraminic Acid	35-46	sialic acid binding Ig like lectin 9	Homo sapiens	0-8
23678987-2	2013	RESULTS: In this study, we showed a significant reduction of sialic acid content in neonatal antithrombin compared with adult antithrombin in mice.	N-Acetylneuraminic Acid	61-72	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	93-105
23610394-4	2013	CD169 is known as sialoadhesin (Sn), a macrophage-specific adhesion and endocytic receptor of the siglec family that recognizes sialic acid containing glycans as ligands.	N-Acetylneuraminic Acid	128-139	sialic acid binding Ig like lectin 1	Homo sapiens	0-5
23610394-4	2013	CD169 is known as sialoadhesin (Sn), a macrophage-specific adhesion and endocytic receptor of the siglec family that recognizes sialic acid containing glycans as ligands.	N-Acetylneuraminic Acid	128-139	sialic acid binding Ig like lectin 1	Homo sapiens	18-30
23610394-4	2013	CD169 is known as sialoadhesin (Sn), a macrophage-specific adhesion and endocytic receptor of the siglec family that recognizes sialic acid containing glycans as ligands.	N-Acetylneuraminic Acid	128-139	sialic acid binding Ig like lectin 1	Homo sapiens	32-34
22544341-6	2013	We found that metastatic L1CAM possesses only alpha2-6-linked sialic acid and the loss of alpha2-3-linked sialic acid in L1CAM is a phenomenon observed during the transition of melanoma cells from VGP to a metastatic stage.	N-Acetylneuraminic Acid	62-73	L1 cell adhesion molecule	Homo sapiens	25-30
23465695-2	2013	We here report the use of the BV/Sf9 (BVES) method for the expression and transfer, via microvesicles, of the exclusive lysosomal exporters for cystine and sialic acid, human cystinosin and sialin.	N-Acetylneuraminic Acid	156-167	blood vessel epicardial substance	Homo sapiens	38-42
23465695-5	2013	Addition of vesicles to cultures of human fibroblast lines deficient in either cystinosin or sialin produced a progressive depletion of stored lysosomal cystine or sialic acid, respectively.	N-Acetylneuraminic Acid	164-175	cystinosin, lysosomal cystine transporter	Homo sapiens	79-89
23247916-1	2013	Influenza A viruses possess two surface glycoproteins, hemagglutinin (HA), which binds to sialic-acid-containing receptors, and neuraminidase (NA), which removes sialic acid from host cells.	N-Acetylneuraminic Acid	162-173	neuraminidase 1	Homo sapiens	128-141
23421394-16	2013	Total SA content of THP was much lower in SP2-positive patients with IC than those who were SP2-negative.	N-Acetylneuraminic Acid	6-8	Sp2 transcription factor	Homo sapiens	42-45
23437777-3	2013	The bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE/MNK), encoded by the GNE gene, catalyzes the first two committed, rate-limiting steps in the biosynthesis of N-acetylneunaminic acid (sialic acid).	N-Acetylneuraminic Acid	200-211	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	62-65
23437777-3	2013	The bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE/MNK), encoded by the GNE gene, catalyzes the first two committed, rate-limiting steps in the biosynthesis of N-acetylneunaminic acid (sialic acid).	N-Acetylneuraminic Acid	200-211	ATPase copper transporting alpha	Homo sapiens	66-69
23437777-3	2013	The bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE/MNK), encoded by the GNE gene, catalyzes the first two committed, rate-limiting steps in the biosynthesis of N-acetylneunaminic acid (sialic acid).	N-Acetylneuraminic Acid	200-211	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	87-90
23161284-0	2013	CXCL14 enhances proliferation and migration of NCI-H460 human lung cancer cells overexpressing the glycoproteins containing heparan sulfate or sialic acid.	N-Acetylneuraminic Acid	143-154	C-X-C motif chemokine ligand 14	Homo sapiens	0-6
22544341-6	2013	We found that metastatic L1CAM possesses only alpha2-6-linked sialic acid and the loss of alpha2-3-linked sialic acid in L1CAM is a phenomenon observed during the transition of melanoma cells from VGP to a metastatic stage.	N-Acetylneuraminic Acid	62-73	immunoglobulin binding protein 1	Homo sapiens	46-54
22544341-6	2013	We found that metastatic L1CAM possesses only alpha2-6-linked sialic acid and the loss of alpha2-3-linked sialic acid in L1CAM is a phenomenon observed during the transition of melanoma cells from VGP to a metastatic stage.	N-Acetylneuraminic Acid	106-117	L1 cell adhesion molecule	Homo sapiens	121-126
22544341-11	2013	The presence of cell surface alpha2-6-linked sialic acid enhances the invasive potential of both primary and metastatic melanoma cells.	N-Acetylneuraminic Acid	45-56	immunoglobulin binding protein 1	Homo sapiens	29-37
23321067-1	2013	Sialic-acid-binding immunoglobulin-like lectin (Siglec5) is a carbohydrate-binding surface receptor expressed on neutrophils, monocytes and B cells in human lymphoid and myeloid cell lineages.	N-Acetylneuraminic Acid	0-11	sialic acid binding Ig like lectin 5	Homo sapiens	48-55
23321067-2	2013	Existing structural and functional data fail to define the clear ligand specificity of Siglec5, though like other Siglec family members, it binds a variety of complex carbohydrates containing a sialic acid at the non-reducing terminus.	N-Acetylneuraminic Acid	194-205	sialic acid binding Ig like lectin 5	Homo sapiens	87-94
23408841-1	2013	Sialoadhesin (Sn) is a sialic acid-binding Ig-like lectin expressed selectively on macrophage subsets.	N-Acetylneuraminic Acid	23-34	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	0-12
23416306-5	2013	Cell surface alpha2,6-sialylation was required for integrin alpha5beta1-dependent cell adhesion to fibronectin, and an increase in alpha2,6-linked sialic acid on alpha5-subunit facilitated fibronectin-mediated focal adhesion kinase phosphorylations, suggesting that alpha2,6-sialylated alpha5-subunit promoted integrin alpha5beta1-dependent cell adhesion.	N-Acetylneuraminic Acid	147-158	fibronectin 1	Mus musculus	189-200
23408841-1	2013	Sialoadhesin (Sn) is a sialic acid-binding Ig-like lectin expressed selectively on macrophage subsets.	N-Acetylneuraminic Acid	23-34	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	14-16
23042406-4	2013	The strong binding of the screened aptamer was enough to protect the hydrolysis of Neu5Ac by neuraminidase with the stoichiometry of 1:1 molar ratio.	N-Acetylneuraminic Acid	83-89	neuraminidase 1	Homo sapiens	93-106
23315163-2	2013	Here, we demonstrate for the first time that sialic acid binding Ig-like lectin E (siglec-E) functions to selectively regulate early neutrophil recruitment into the lung.	N-Acetylneuraminic Acid	45-56	sialic acid binding Ig-like lectin E	Mus musculus	83-91
23315163-5	2013	Sialidase treatment of fibrinogen reversed the suppressive effect of siglec-E on CD11b signaling, suggesting that sialic acid recognition by siglec-E is required for its inhibitory function.	N-Acetylneuraminic Acid	114-125	fibrinogen beta chain	Homo sapiens	23-33
23315163-5	2013	Sialidase treatment of fibrinogen reversed the suppressive effect of siglec-E on CD11b signaling, suggesting that sialic acid recognition by siglec-E is required for its inhibitory function.	N-Acetylneuraminic Acid	114-125	sialic acid binding Ig-like lectin E	Mus musculus	69-77
23315163-5	2013	Sialidase treatment of fibrinogen reversed the suppressive effect of siglec-E on CD11b signaling, suggesting that sialic acid recognition by siglec-E is required for its inhibitory function.	N-Acetylneuraminic Acid	114-125	integrin subunit alpha M	Homo sapiens	81-86
23315163-5	2013	Sialidase treatment of fibrinogen reversed the suppressive effect of siglec-E on CD11b signaling, suggesting that sialic acid recognition by siglec-E is required for its inhibitory function.	N-Acetylneuraminic Acid	114-125	sialic acid binding Ig-like lectin E	Mus musculus	141-149
23173866-5	2013	Using a well-defined GBS/MFS-associated C. jejuni strain collection, which included three sialic acid knockout strains, we found that Siglec-7 exclusively binds to C. jejuni strains that express terminal disialylated ganglioside mimics.	N-Acetylneuraminic Acid	90-101	sialic acid binding Ig like lectin 7	Homo sapiens	134-142
23527859-5	2013	Because a simple sialylation reaction was not enough to increase the sialic acid content, a combined reaction using galactosyltransferase, sialyltransferase, and their sugar substrates at the same time was developed and optimized to reduce the incubation time.	N-Acetylneuraminic Acid	69-80	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	139-156
23382102-6	2013	RESULTS: Sialic acid levels were markedly reduced (60-80%) in muscles from dystrophin-defective mice, delta-sarcoglycan-deficient hamsters, merosin-deficient mice, and patients with muscular dystrophy, when compared with their healthy counterparts.	N-Acetylneuraminic Acid	9-20	laminin, alpha 2	Mus musculus	140-147
23173866-3	2013	Antigen recognition is a crucial first step in the induction of a cross-reactive antibody response, and it has been shown that GQ1b-like epitopes expressed on the surface of C. jejuni are recognized by sialic acid-binding immunoglobulin-like lectin-7 (Siglec-7).	N-Acetylneuraminic Acid	202-213	sialic acid binding Ig like lectin 7	Homo sapiens	252-260
23772422-8	2013	The sialic acid linked alpha 2-6 and sialyl Lewisx structures were significantly increased in cancerous cells when compared to normal and intermediate renal tissue.	N-Acetylneuraminic Acid	4-15	immunoglobulin binding protein 1	Homo sapiens	23-32
23517790-8	2013	Total sialic acid showed significant positive correlation with HOMA-IR (p&lt;0.01), BMI (p&lt;0.01), waist and hip circumference (p&lt;0.01) and negative correlation with QUICKI (p&lt;0.01) and insulin sensitivity index (p=0.018).	N-Acetylneuraminic Acid	6-17	insulin	Homo sapiens	194-201
23004020-7	2013	We also investigated the differences in the effects of GM3 (N-acetylneuraminic acid [NeuAc]) and GM3 (NeuGc) on inhibition of epidermal growth factor receptor (EGFR) tyrosine kinase in A431 cells.	N-Acetylneuraminic Acid	85-90	epidermal growth factor receptor	Homo sapiens	126-158
23004020-12	2013	The difference in the effects of GM3 (NeuGc) and GM3 (NeuAc) on the inhibition of EGFR tyrosine kinase might contribute to improvement in the prognosis of NSCLC patients.	N-Acetylneuraminic Acid	54-59	epidermal growth factor receptor	Homo sapiens	82-86
23924466-9	2013	Fucose, sialic acid and galactose were all detected on the recombinant TPO ectodomain.	N-Acetylneuraminic Acid	8-19	thyroid peroxidase	Homo sapiens	71-74
23517790-0	2013	Relationship of raised serum total and protein bound sialic acid levels with hyperinsulinemia and indices of insulin sensitivity and insulin resistance in non-diabetic normotensive obese subjects.	N-Acetylneuraminic Acid	53-64	insulin	Homo sapiens	82-89
23517790-0	2013	Relationship of raised serum total and protein bound sialic acid levels with hyperinsulinemia and indices of insulin sensitivity and insulin resistance in non-diabetic normotensive obese subjects.	N-Acetylneuraminic Acid	53-64	insulin	Homo sapiens	109-116
23517790-10	2013	CONCLUSION: Sialic acid levels are elevated in obese subjects and its association with insulin resistance and reduced insulin sensitivity may enhance the cardiovascular risk in these subjects.	N-Acetylneuraminic Acid	12-23	insulin	Homo sapiens	87-94
23517790-10	2013	CONCLUSION: Sialic acid levels are elevated in obese subjects and its association with insulin resistance and reduced insulin sensitivity may enhance the cardiovascular risk in these subjects.	N-Acetylneuraminic Acid	12-23	insulin	Homo sapiens	118-125
23135722-3	2013	The role of gangliosides in rotavirus cell entry was studied by silencing the expression of two key enzymes involved in their biosynthesis--the UDP-glucose:ceramide glucosyltransferase (UGCG), which transfers a glucose molecule to ceramide to produce glucosylceramide GlcCer, and the lactosyl ceramide-alpha-2,3-sialyl transferase 5 (GM3-s), which adds the first SA to lactoceramide-producing ganglioside GM3.	N-Acetylneuraminic Acid	363-365	UDP-glucose ceramide glucosyltransferase	Homo sapiens	144-184
23135722-3	2013	The role of gangliosides in rotavirus cell entry was studied by silencing the expression of two key enzymes involved in their biosynthesis--the UDP-glucose:ceramide glucosyltransferase (UGCG), which transfers a glucose molecule to ceramide to produce glucosylceramide GlcCer, and the lactosyl ceramide-alpha-2,3-sialyl transferase 5 (GM3-s), which adds the first SA to lactoceramide-producing ganglioside GM3.	N-Acetylneuraminic Acid	363-365	UDP-glucose ceramide glucosyltransferase	Homo sapiens	186-190
23381854-2	2013	Frequent modification of O-acetylations at positions C-7, C-8, or C-9 of Sias generates a family of O-acetylated sialic acid (O-AcSia) and plays crucial roles in many cellular events like cell-cell adhesion, proliferation, migration, etc.	N-Acetylneuraminic Acid	113-124	complement C7	Homo sapiens	53-56
23381854-2	2013	Frequent modification of O-acetylations at positions C-7, C-8, or C-9 of Sias generates a family of O-acetylated sialic acid (O-AcSia) and plays crucial roles in many cellular events like cell-cell adhesion, proliferation, migration, etc.	N-Acetylneuraminic Acid	113-124	homeobox C8	Homo sapiens	58-61
23381854-2	2013	Frequent modification of O-acetylations at positions C-7, C-8, or C-9 of Sias generates a family of O-acetylated sialic acid (O-AcSia) and plays crucial roles in many cellular events like cell-cell adhesion, proliferation, migration, etc.	N-Acetylneuraminic Acid	113-124	complement C9	Homo sapiens	66-69
23727707-7	2013	Therefore, it has been suggested that NR2, the putative sialic acid-binding domain of Hsa, is presented on the bacterial surface at the end of a long molecular stalk formed by SR2.	N-Acetylneuraminic Acid	56-67	albumin	Homo sapiens	86-89
23468914-7	2013	Metabolic labeling experiments using the tritiated sialic acid precursor N-acetyl-D-mannosamine (ManNAc) revealed a significant decline (~30%) of its incorporation into newly synthesized sialoglycoproteins in a TGFBR2-dependent manner.	N-Acetylneuraminic Acid	51-62	transforming growth factor beta receptor 2	Homo sapiens	211-217
23544079-3	2013	Characterization of the anti-IAV activity of SAP after periodate or bacterial sialidase treatment demonstrated that alpha(2,6)-linked sialic acid residues on the glycosidic moiety of SAP are critical for recognition by the HA of susceptible IAV strains.	N-Acetylneuraminic Acid	134-145	amyloid P component, serum	Homo sapiens	45-48
23544079-3	2013	Characterization of the anti-IAV activity of SAP after periodate or bacterial sialidase treatment demonstrated that alpha(2,6)-linked sialic acid residues on the glycosidic moiety of SAP are critical for recognition by the HA of susceptible IAV strains.	N-Acetylneuraminic Acid	134-145	amyloid P component, serum	Homo sapiens	183-186
23544079-6	2013	Given the widespread expression of alpha(2,6)-linked sialic acid in the human respiratory tract, we propose that SAP may act as an effective receptor mimic to limit IAV infection of airway epithelial cells.	N-Acetylneuraminic Acid	53-64	amyloid P component, serum	Homo sapiens	113-116
23457550-4	2013	The crystal structure of this region revealed a dimer that is presumed to represent the glycophorin A binding conformation as sialic acid binding sites and large cavities are observed at the dimer interface.	N-Acetylneuraminic Acid	126-137	glycophorin A (MNS blood group)	Homo sapiens	88-101
22958948-3	2012	Sialoadhesin, a macrophage restricted lectin that binds sialic acid, was originally described as a sheep erythrocyte binding receptor.	N-Acetylneuraminic Acid	56-67	sialic acid binding Ig like lectin 1	Homo sapiens	0-12
22958948-10	2012	These data support the hypothesis that porcine sialoadhesin is a xenogeneic receptor that mediates porcine macrophage binding of human erythrocytes in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	153-164	sialic acid binding Ig like lectin 1	Homo sapiens	47-59
22945870-4	2012	More recently, B cells and the sialic acid-binding protein CD22 were suggested to be involved in this IVIg-dependent immunomodulatory pathway.	N-Acetylneuraminic Acid	31-42	CD22 antigen	Mus musculus	59-63
23122659-2	2012	The disorder results from biallelic mutations in GNE, encoding UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, the key enzyme of sialic acid synthesis.	N-Acetylneuraminic Acid	145-156	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	49-52
22833315-0	2012	Amino acid residues important for CMP-sialic acid recognition by the CMP-sialic acid transporter: analysis of the substrate specificity of UDP-galactose/CMP-sialic acid transporter chimeras.	N-Acetylneuraminic Acid	38-49	solute carrier family 35 member A1	Homo sapiens	69-96
23026019-0	2012	Detection of prostate cancer by sialic acid level in patients with non-diagnostic levels of prostate-specific antigen.	N-Acetylneuraminic Acid	32-43	kallikrein related peptidase 3	Homo sapiens	92-117
23026019-7	2012	CONCLUSION: Sialic acid can be used as an adjunct in predicting prostate malignancy when PSA values fall in the grey zone.	N-Acetylneuraminic Acid	12-23	kallikrein related peptidase 3	Homo sapiens	89-92
23122659-2	2012	The disorder results from biallelic mutations in GNE, encoding UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, the key enzyme of sialic acid synthesis.	N-Acetylneuraminic Acid	145-156	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	63-125
23122659-10	2012	These preclinical data strongly support further evaluation of oral ManNAc, Neu5Ac and ManN as therapy for GNE myopathy and conceivably for certain glomerular diseases with hyposialylation.	N-Acetylneuraminic Acid	75-81	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	106-109
23593873-0	2012	[Extracellular sialidase degrades sialic acid in recombinant human erythropoietin produced by an industrial Chinese hamster ovary cell strain].	N-Acetylneuraminic Acid	34-45	erythropoietin	Homo sapiens	67-81
23203118-0	2012	Detection of glycomic alterations induced by overexpression of p-glycoprotein on the surfaces of L1210 cells using sialic acid binding lectins.	N-Acetylneuraminic Acid	115-126	phosphoglycolate phosphatase	Mus musculus	63-77
23098908-1	2012	Aberrant O-glycosylation in the hinge region of serum IgA is suggested to be involved in the pathogenesis of IgA nephropathy (IgAN), because the hypoglycosylation including N-acetylneuraminic acid or galactose has been reported in the mucin-type O-glycan of the hinge portion (HP) of IgA deposited in the IgAN patients" kidney.	N-Acetylneuraminic Acid	173-196	CD79a molecule	Homo sapiens	54-57
23098908-1	2012	Aberrant O-glycosylation in the hinge region of serum IgA is suggested to be involved in the pathogenesis of IgA nephropathy (IgAN), because the hypoglycosylation including N-acetylneuraminic acid or galactose has been reported in the mucin-type O-glycan of the hinge portion (HP) of IgA deposited in the IgAN patients" kidney.	N-Acetylneuraminic Acid	173-196	IGAN1	Homo sapiens	126-130
23098908-1	2012	Aberrant O-glycosylation in the hinge region of serum IgA is suggested to be involved in the pathogenesis of IgA nephropathy (IgAN), because the hypoglycosylation including N-acetylneuraminic acid or galactose has been reported in the mucin-type O-glycan of the hinge portion (HP) of IgA deposited in the IgAN patients" kidney.	N-Acetylneuraminic Acid	173-196	CD79a molecule	Homo sapiens	109-112
22962865-0	2012	Short-term intra-nasal erythropoietin administration with low sialic acid content is without toxicity or erythropoietic effects.	N-Acetylneuraminic Acid	62-73	erythropoietin	Rattus norvegicus	23-37
22962865-1	2012	The objective of this investigation was to assess the toxicological potential of nasal formulation of erythropoietin with low sialic acid content (Neuro EPO) after 28 days of intra-nasal dosing in rats besides to evaluate the immunogenicity and erythropoietic effect of the test substance.	N-Acetylneuraminic Acid	126-137	erythropoietin	Rattus norvegicus	102-116
22943525-0	2012	Tumour suppressor p16(INK4a)  - anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model.	N-Acetylneuraminic Acid	131-142	cyclin dependent kinase inhibitor 2A	Homo sapiens	18-21
22943525-0	2012	Tumour suppressor p16(INK4a)  - anoikis-favouring decrease in N/O-glycan/cell surface sialylation by down-regulation of enzymes in sialic acid biosynthesis in tandem in a pancreatic carcinoma model.	N-Acetylneuraminic Acid	131-142	cyclin dependent kinase inhibitor 2A	Homo sapiens	22-27
22943525-7	2012	Partial restoration of sialylation in GNE-transfected cells supports the implied role of sialic acid availability for the glycophenotype.	N-Acetylneuraminic Acid	89-100	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	38-41
22943525-9	2012	Thus, a second means of modulating cell reactivity to the growth effector galectin-1 is established in addition to the common route of altering alpha2,6-sialyltransferase expression: regulating enzymes of the pathway for sialic acid biosynthesis.	N-Acetylneuraminic Acid	221-232	galectin 1	Homo sapiens	74-84
25893133-4	2012	Taxol treatment upregulated the expression of human GM3 synthase, an enzyme that transfers a sialic acid to lactosylceramide.	N-Acetylneuraminic Acid	93-104	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	52-64
22633753-2	2012	GNE encodes the bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetyl mannosamine kinase, the key enzyme in the biosynthesis pathway of sialic acid.	N-Acetylneuraminic Acid	147-158	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
22633753-2	2012	GNE encodes the bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetyl mannosamine kinase, the key enzyme in the biosynthesis pathway of sialic acid.	N-Acetylneuraminic Acid	147-158	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	36-99
22820001-9	2012	Neuraminidase and fucosidase treatments of sLe(x) microspheres revealed that sialic acid and fucose are required for E-selectin binding, whereas HECA-452 recognition of sLe(x) does not depend on the fucose moiety to the extent required for E-selectin recognition.	N-Acetylneuraminic Acid	77-88	selectin E	Homo sapiens	117-127
23038623-2	2012	Microarray printing of the library and screening with the siglec family of sialic-acid-binding proteins, led to the identification of high-affinity ligands for siglec-9 and siglec-10.	N-Acetylneuraminic Acid	75-86	sialic acid binding Ig like lectin 9	Homo sapiens	160-168
23038623-2	2012	Microarray printing of the library and screening with the siglec family of sialic-acid-binding proteins, led to the identification of high-affinity ligands for siglec-9 and siglec-10.	N-Acetylneuraminic Acid	75-86	sialic acid binding Ig like lectin 10	Homo sapiens	173-182
22565051-10	2012	This work elucidates the impact that certain structures of sialic acid and its analogs can have on Abeta binding.	N-Acetylneuraminic Acid	59-70	amyloid beta precursor protein	Homo sapiens	99-104
22526486-2	2012	Sialoadhesin is a macrophage adhesion molecule containing 17 extracellular immunoglobulin-like domains, and is an I-type lectin which binds to sialic acid ligands expressed on hematopoietic cells.	N-Acetylneuraminic Acid	143-154	sialic acid binding Ig like lectin 1	Homo sapiens	0-12
22881213-5	2012	However, considering that some NeuAc-binding lectins are capable of binding to N-acetylglucosamine (GlcNAc), other GlcNAc-binding lectins were also assayed.	N-Acetylneuraminic Acid	31-36	alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	Xenopus laevis	100-106
22669578-4	2012	Binding of F4 fimbriae to pAPN depended on sialic acid containing carbohydrate moieties, and resulted in clathrin-mediated endocytosis of the fimbriae.	N-Acetylneuraminic Acid	43-54	alanyl aminopeptidase, membrane	Sus scrofa	26-30
23287327-2	2012	It is an autosomal recessive disorder and is due to mutations in the GNE gene that regulates the synthesis of sialic acid.	N-Acetylneuraminic Acid	110-121	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	69-72
22777817-0	2012	Targeting of CD22-positive B-cell lymphoma cells by synthetic divalent sialic acid analogues.	N-Acetylneuraminic Acid	71-82	CD22 molecule	Homo sapiens	13-17
22745475-7	2012	Although the Cmas(nls) mouse displayed normal sialylation in all organs including kidney, a critical shortage of CMP-sialic acid prevented sialylation of nephrin and podocalyxin in the maturing podocyte where it is required during the formation of foot processes.	N-Acetylneuraminic Acid	117-128	cytidine monophospho-N-acetylneuraminic acid synthetase	Mus musculus	13-17
22714643-9	2012	The SSL3-TLR2 interaction is partially glycan dependent as binding of SSL3 to TLR2 is affected upon removal of sialic acid residues.	N-Acetylneuraminic Acid	111-122	toll-like receptor 2 type-1	Gallus gallus	9-13
22714643-9	2012	The SSL3-TLR2 interaction is partially glycan dependent as binding of SSL3 to TLR2 is affected upon removal of sialic acid residues.	N-Acetylneuraminic Acid	111-122	toll-like receptor 2 type-1	Gallus gallus	78-82
22837202-0	2012	Entry of influenza A Virus with a alpha2,6-linked sialic acid binding preference requires host fibronectin.	N-Acetylneuraminic Acid	50-61	fibronectin 1	Homo sapiens	95-106
22944676-7	2012	Furthermore, subclones of BJA-B and HL-60 cells, which completely lack UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis, contained almost no sialylated N-glycans.	N-Acetylneuraminic Acid	159-170	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	135-138
22944680-0	2012	Glycoengineering the N-acyl side chain of sialic acid of human erythropoietin affects its resistance to sialidase.	N-Acetylneuraminic Acid	42-53	erythropoietin	Homo sapiens	63-77
22585296-6	2012	Sialic acid-dependent binding of siglec-7 tetramers was confirmed by glycan array analysis and loss of siglec tetramer binding after neuraminidase treatment of lymphocytes.	N-Acetylneuraminic Acid	0-11	sialic acid binding Ig like lectin 7	Homo sapiens	33-41
22967315-3	2012	Sialoadhesin (Sn, Siglec-1, CD169), a sialic acid-binding immunoglobulin-like lectin (Siglec) expressed on subsets of resident and inflammatory macrophages, is an attractive target for the development of a ligand-targeted delivery system.	N-Acetylneuraminic Acid	38-49	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	0-12
22967315-3	2012	Sialoadhesin (Sn, Siglec-1, CD169), a sialic acid-binding immunoglobulin-like lectin (Siglec) expressed on subsets of resident and inflammatory macrophages, is an attractive target for the development of a ligand-targeted delivery system.	N-Acetylneuraminic Acid	38-49	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	18-26
22967315-7	2012	The most potent of these Sn ligands, 9-N-(4H-thieno[3,2-c]chromene-2-carbamoyl)-Neu5Acalpha2-3Galbeta1-4GlcNAc ((TCC)Neu5Ac), was conjugated to lipids for display on a liposomal nanoparticle for evaluation of targeted delivery to cells.	N-Acetylneuraminic Acid	80-86	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	25-27
22901108-2	2012	Derivatization of the sialic acids with 2-aminoacridone (2-AMAC), using classical reductive amination in a nonaqueous solvent, led to the spontaneous decarboxylation of the sialic acid residues as determined by CE-LIF and offline mass spectrometric analysis.	N-Acetylneuraminic Acid	22-33	solute carrier family 35 member G5	Homo sapiens	59-63
22895089-6	2012	The presence of a terminal sialic acid moiety, a rare modification of mammalian GPI anchors, was essential in the activation of cPLA 2 and synapse damage induced by cross-linked PrP (C).	N-Acetylneuraminic Acid	27-38	phospholipase A2 group IVA	Homo sapiens	128-134
22895089-7	2012	We conclude that the sialic acid modifies local membrane microenvironments (rafts) surrounding clustered PrP molecules resulting in aberrant activation of cPLA 2 and synapse damage.	N-Acetylneuraminic Acid	21-32	prion protein	Homo sapiens	105-108
22895089-7	2012	We conclude that the sialic acid modifies local membrane microenvironments (rafts) surrounding clustered PrP molecules resulting in aberrant activation of cPLA 2 and synapse damage.	N-Acetylneuraminic Acid	21-32	phospholipase A2 group IVA	Homo sapiens	155-161
22581805-6	2012	Mass spectra and proton NMR spectroscopy revealed an abundant NeuAc linked to internally positioned N-acetylglucosamine on colonic murine Muc2, which also differs markedly from human MUC2.	N-Acetylneuraminic Acid	62-67	mucin 2	Mus musculus	138-142
22745475-7	2012	Although the Cmas(nls) mouse displayed normal sialylation in all organs including kidney, a critical shortage of CMP-sialic acid prevented sialylation of nephrin and podocalyxin in the maturing podocyte where it is required during the formation of foot processes.	N-Acetylneuraminic Acid	117-128	nephrosis 1, nephrin	Mus musculus	154-161
22745475-7	2012	Although the Cmas(nls) mouse displayed normal sialylation in all organs including kidney, a critical shortage of CMP-sialic acid prevented sialylation of nephrin and podocalyxin in the maturing podocyte where it is required during the formation of foot processes.	N-Acetylneuraminic Acid	117-128	podocalyxin-like	Mus musculus	166-177
22718032-5	2012	Luminal mucin content correlated with sialic acid (r = 0.96; P &lt; 0.001) or sulfate (r = 0.62; P &lt; 0.01), but the slope of the sialic acid-derived equation was greater than that of the sulfate-derived equation, indicating a preferred increase in sialylated mucins.	N-Acetylneuraminic Acid	38-49	solute carrier family 13 member 2	Rattus norvegicus	8-13
22802576-4	2012	In patients with IgAN, circulating IgA1 molecules have an aberrant structure of O-glycans in the hinge region, which is characterized by abbreviated glycans composed of N-acetylgalactosamine, with or without sialic acid.	N-Acetylneuraminic Acid	208-219	IGAN1	Homo sapiens	17-21
22677186-5	2012	This review highlights recent insights into B cell tolerance to theoretical self TI-2 Ags, and examines how the B cell-restricted sialic acid binding Ig-like lectins (Siglecs), CD22 and Siglec-G, might contribute to this process.	N-Acetylneuraminic Acid	130-141	CD22 antigen	Mus musculus	177-181
22679891-4	2012	Treatment of the cystatin C-containing CM with enzymes that remove O- and sialic acid-, but not N-linked carbohydrate moieties markedly reduced the ability of the DA neuronal CM to activate microglia.	N-Acetylneuraminic Acid	74-85	cystatin C	Rattus norvegicus	17-27
22703338-0	2012	Evidence for helical structure in a tetramer of alpha2-8 sialic acid: unveiling a structural antigen.	N-Acetylneuraminic Acid	57-68	immunoglobulin binding protein 1	Homo sapiens	48-56
22802576-4	2012	In patients with IgAN, circulating IgA1 molecules have an aberrant structure of O-glycans in the hinge region, which is characterized by abbreviated glycans composed of N-acetylgalactosamine, with or without sialic acid.	N-Acetylneuraminic Acid	208-219	immunoglobulin heavy constant alpha 1	Homo sapiens	35-39
22022932-9	2012	NEU2, formerly known as sialidase 2, belongs to a family of enzymes that cleave sialic acid from polysaccharide chains.	N-Acetylneuraminic Acid	80-91	neuraminidase 2	Equus caballus	0-4
22528484-0	2012	Sialic acid associated with alphavbeta3 integrin mediates HIV-1 Tat protein interaction and endothelial cell proangiogenic activation.	N-Acetylneuraminic Acid	0-11	Tat	Human immunodeficiency virus 1	64-67
22528484-5	2012	alpha(v)beta(3) immunoprecipitation with biotinylated MAA or Western blot analysis of neuraminidase-treated ECs demonstrated that NeuAc is associated with both the alpha(v) and the beta(3) subunits.	N-Acetylneuraminic Acid	130-135	neuraminidase 1	Homo sapiens	86-99
22528484-6	2012	Surface plasmon resonance analysis demonstrated that the masking of alpha(v)beta(3)-associated NeuAc by MAA prevents Tat/alpha(v)beta(3) interaction.	N-Acetylneuraminic Acid	95-100	tyrosine aminotransferase	Homo sapiens	117-120
22528484-11	2012	In conclusion, NeuAc is associated with endothelial alpha(v)beta(3) and mediates Tat-dependent EC adhesion and proangiogenic activation.	N-Acetylneuraminic Acid	15-20	tyrosine aminotransferase	Homo sapiens	81-84
22022932-10	2012	The expression of NEU2 described herein provides a mechanism by which the conceptus can regulate the sialic acid content of its own capsule.	N-Acetylneuraminic Acid	101-112	neuraminidase 2	Equus caballus	18-22
22396535-6	2012	Sialylation-dependent ligand recognition is also a property of SIGLEC1, a member of the sialic acid-binding Ig-like lectins.	N-Acetylneuraminic Acid	88-99	sialic acid binding Ig like lectin 1	Homo sapiens	63-70
22529385-4	2012	Entry into GnT1-deficient cells was fully dependent on sialic acid.	N-Acetylneuraminic Acid	55-66	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	11-15
22396535-10	2012	Binding studies suggest that PILRalpha recognizes a complex ligand domain involving both sialic acid and protein motif(s).	N-Acetylneuraminic Acid	89-100	paired immunoglobin like type 2 receptor alpha	Homo sapiens	29-38
22085395-5	2012	Some sialic acid containing glycoproteins, including neural cell adhesion molecule (NCAM), are hyposialylated in HIBM muscle biopsy samples.	N-Acetylneuraminic Acid	5-16	neural cell adhesion molecule 1	Homo sapiens	53-82
22585926-4	2012	Sialic acid (Sia), a family of 9-carbon sugar acids, occurs in large amounts in human milk oligosaccharides and is an essential component of brain gangliosides and sialylated glycoproteins, particularly as precursors for the synthesis of the polysialic acid (polySia) glycan that post-translationally modify the cell membrane-associated neural cell adhesion molecules (NCAM).	N-Acetylneuraminic Acid	0-11	neural cell adhesion molecule 1	Homo sapiens	337-367
22585926-4	2012	Sialic acid (Sia), a family of 9-carbon sugar acids, occurs in large amounts in human milk oligosaccharides and is an essential component of brain gangliosides and sialylated glycoproteins, particularly as precursors for the synthesis of the polysialic acid (polySia) glycan that post-translationally modify the cell membrane-associated neural cell adhesion molecules (NCAM).	N-Acetylneuraminic Acid	0-11	neural cell adhesion molecule 1	Homo sapiens	369-373
22085395-5	2012	Some sialic acid containing glycoproteins, including neural cell adhesion molecule (NCAM), are hyposialylated in HIBM muscle biopsy samples.	N-Acetylneuraminic Acid	5-16	neural cell adhesion molecule 1	Homo sapiens	84-88
22393058-1	2012	Modulation of levels of polysialic acid (polySia), a sialic acid polymer, predominantly associated with the neural cell adhesion molecule (NCAM), influences neural functions, including synaptic plasticity, neurite growth, and cell migration.	N-Acetylneuraminic Acid	28-39	neural cell adhesion molecule 1	Mus musculus	108-137
22450957-3	2012	Sialoadhesin is a major macrophage receptor that specifically recognizes sialic acid, an abundant component of host glycoconjugates but which can also be found on several human pathogens.	N-Acetylneuraminic Acid	73-84	sialic acid binding Ig like lectin 1	Homo sapiens	0-12
22393058-1	2012	Modulation of levels of polysialic acid (polySia), a sialic acid polymer, predominantly associated with the neural cell adhesion molecule (NCAM), influences neural functions, including synaptic plasticity, neurite growth, and cell migration.	N-Acetylneuraminic Acid	28-39	neural cell adhesion molecule 1	Mus musculus	139-143
22246380-11	2012	Analysis of DARC glycans performed by means of lectin blotting and glycosidase digestion suggests that native Duffy N-glycans are mostly triantennary complex-type, terminated with alpha2-3- and alpha2-6-linked sialic acid residues with bisecting GlcNAc and alpha1-6-linked fucose at the core.	N-Acetylneuraminic Acid	210-221	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	12-16
22281425-5	2012	Furthermore, conjugation of sialic acid (SA) on the surface of ChNPs enabled receptor-mediated targeted gene delivery to CD22-expressing cells.	N-Acetylneuraminic Acid	28-39	CD22 molecule	Homo sapiens	121-125
22281425-5	2012	Furthermore, conjugation of sialic acid (SA) on the surface of ChNPs enabled receptor-mediated targeted gene delivery to CD22-expressing cells.	N-Acetylneuraminic Acid	41-43	CD22 molecule	Homo sapiens	121-125
22278120-5	2012	Further analysis showed that the IVIg-mediated amelioration of platelet phagocytosis was fully dependent on terminal sialic acid residues in the IVIg preparation and could be blocked with a specific ICAM3 grabbing nonintegrin-related 1 (SIGNR1) specific antibody.	N-Acetylneuraminic Acid	117-128	CD209b antigen	Mus musculus	237-243
22301136-4	2012	The SA binding pocket of the HA1 subunit has been extensively studied, and a number of residues important for receptor binding have been identified.	N-Acetylneuraminic Acid	4-6	Rho GTPase activating protein 45	Homo sapiens	29-32
22334707-3	2012	Using structure-activity, homology modeling, molecular docking, and mutagenesis studies, we have located the substrate-binding site of sialin (SLC17A5), a lysosomal sialic acid exporter also recently implicated in exocytotic release of aspartate.	N-Acetylneuraminic Acid	165-176	solute carrier family 17 member 5	Homo sapiens	135-141
22334707-3	2012	Using structure-activity, homology modeling, molecular docking, and mutagenesis studies, we have located the substrate-binding site of sialin (SLC17A5), a lysosomal sialic acid exporter also recently implicated in exocytotic release of aspartate.	N-Acetylneuraminic Acid	165-176	solute carrier family 17 member 5	Homo sapiens	143-150
22334707-4	2012	Human sialin is defective in two inherited sialic acid storage diseases and is responsible for metabolic incorporation of the dietary nonhuman sialic acid N-glycolylneuraminic acid.	N-Acetylneuraminic Acid	43-54	solute carrier family 17 member 5	Homo sapiens	6-12
22334707-4	2012	Human sialin is defective in two inherited sialic acid storage diseases and is responsible for metabolic incorporation of the dietary nonhuman sialic acid N-glycolylneuraminic acid.	N-Acetylneuraminic Acid	143-154	solute carrier family 17 member 5	Homo sapiens	6-12
21140242-11	2012	The high expression of ST3Gal IV may contribute to the expression of alpha 2,3-linked sialic acid residues, which is associated with the malignant behavior of gastric cancer cells.	N-Acetylneuraminic Acid	86-97	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	23-32
22376076-7	2012	Low sialic acid-containing EPO (Neuro EPO) is very similar to the one that occurs in the mammalian brain and is rapidly degraded by the liver.	N-Acetylneuraminic Acid	4-15	erythropoietin	Homo sapiens	27-30
22376076-7	2012	Low sialic acid-containing EPO (Neuro EPO) is very similar to the one that occurs in the mammalian brain and is rapidly degraded by the liver.	N-Acetylneuraminic Acid	4-15	erythropoietin	Homo sapiens	38-41
22191536-8	2012	It was found that FBP from human milk contains putative structures that have composition consistent with high-mannose (Hex(5-6)HexNAc(2)) as well as hybrid and complex N-linked glycans (NeuAc(0-1)Fuc(0-3)Hex(3-6)HexNAc(3-5)).	N-Acetylneuraminic Acid	186-191	folate receptor alpha	Homo sapiens	18-21
22191536-9	2012	The FBP from bovine milk contains putative structures corresponding to high-mannose (Hex(4-9)HexNAc(2)) as well as hybrid and complex N-linked glycans (Hex(3-6)HexNAc(3-6)), but these glycans mostly do not contain fucose and sialic acid.	N-Acetylneuraminic Acid	225-236	folate receptor alpha	Bos taurus	4-7
22402719-2	2012	The disease is caused mostly by missense mutations in the GNE gene that encodes a protein with two enzymatic activities in sialic acid biosynthetic pathway: UDP-GlcNAc 2-epimerase and ManNAc kinase, respectively catalyzing the rate-limiting step and the subsequent reaction.	N-Acetylneuraminic Acid	123-134	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	58-61
22402719-2	2012	The disease is caused mostly by missense mutations in the GNE gene that encodes a protein with two enzymatic activities in sialic acid biosynthetic pathway: UDP-GlcNAc 2-epimerase and ManNAc kinase, respectively catalyzing the rate-limiting step and the subsequent reaction.	N-Acetylneuraminic Acid	123-134	renin binding protein	Homo sapiens	161-179
21974967-5	2012	At least some of this ability of ANGPTL4 to induce proteinuria is linked to a deficiency of sialic acid residues because oral supplementation with sialic acid precursor N-acetyl-d-mannosamine improves sialylation of podocyte-secreted ANGPTL4 and significantly decreases proteinuria.	N-Acetylneuraminic Acid	92-103	angiopoietin like 4	Homo sapiens	33-40
22539431-8	2012	The combined results showed an increase in terminal alpha 2-6 linked sialic acid in the N-glycans found on KLK6 from ovarian cancer serum and ascites, as opposed to CSF and serum of normal individuals.	N-Acetylneuraminic Acid	69-80	kallikrein related peptidase 6	Homo sapiens	107-111
22101895-1	2012	When refrigerated platelets are rewarmed, they secrete active sialidases, including the lysosomal sialidase Neu1, and express surface Neu3 that remove sialic acid from platelet von Willebrand factor receptor (VWFR), specifically the GPIbalpha subunit.	N-Acetylneuraminic Acid	151-162	neuraminidase 3	Mus musculus	134-138
21933198-0	2012	Characterization of sialic acid index of plasma apolipoprotein J and phosphatidylethanol during alcohol detoxification--a pilot study.	N-Acetylneuraminic Acid	20-31	clusterin	Homo sapiens	48-64
21933198-2	2012	Previous studies have shown progressive recovery of ApoJ sialic acid content with increased duration of alcohol abstinence.	N-Acetylneuraminic Acid	57-68	clusterin	Homo sapiens	52-56
21933198-3	2012	Therefore, the sialic acid index of plasma apolipoprotein J (SIJ) seems to be a promising alcohol biomarker.	N-Acetylneuraminic Acid	15-26	clusterin	Homo sapiens	43-59
21974967-5	2012	At least some of this ability of ANGPTL4 to induce proteinuria is linked to a deficiency of sialic acid residues because oral supplementation with sialic acid precursor N-acetyl-d-mannosamine improves sialylation of podocyte-secreted ANGPTL4 and significantly decreases proteinuria.	N-Acetylneuraminic Acid	92-103	angiopoietin like 4	Homo sapiens	234-241
21974967-5	2012	At least some of this ability of ANGPTL4 to induce proteinuria is linked to a deficiency of sialic acid residues because oral supplementation with sialic acid precursor N-acetyl-d-mannosamine improves sialylation of podocyte-secreted ANGPTL4 and significantly decreases proteinuria.	N-Acetylneuraminic Acid	147-158	angiopoietin like 4	Homo sapiens	33-40
21974967-5	2012	At least some of this ability of ANGPTL4 to induce proteinuria is linked to a deficiency of sialic acid residues because oral supplementation with sialic acid precursor N-acetyl-d-mannosamine improves sialylation of podocyte-secreted ANGPTL4 and significantly decreases proteinuria.	N-Acetylneuraminic Acid	147-158	angiopoietin like 4	Homo sapiens	234-241
22262892-0	2012	Sialic acid on the neuronal glycocalyx prevents complement C1 binding and complement receptor-3-mediated removal by microglia.	N-Acetylneuraminic Acid	0-11	integrin alpha M	Mus musculus	74-95
22049060-5	2012	Silencing of GNE, the key enzyme of sialic acid biosynthesis, sensitizes pancreatic cancer cells to anoikis.	N-Acetylneuraminic Acid	36-47	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	13-16
21880669-5	2012	KL-6/MUC1 contained core 1 and extended core 1 glycans modified with one or two sialic acid/sulfate residues.	N-Acetylneuraminic Acid	80-91	mucin 1, cell surface associated	Homo sapiens	0-4
21880669-5	2012	KL-6/MUC1 contained core 1 and extended core 1 glycans modified with one or two sialic acid/sulfate residues.	N-Acetylneuraminic Acid	80-91	mucin 1, cell surface associated	Homo sapiens	5-9
21756025-1	2012	CD22 is a member of the siglec (sialic acid-binding immunoglobulin-like lectin) family expressed on B cells that recognizes glycans of glycoproteins as ligands.	N-Acetylneuraminic Acid	32-43	CD22 molecule	Homo sapiens	0-4
22157763-1	2012	Distal myopathy with rimmed vacuoles/hereditary inclusion body myopathy (DMRV/hIBM), characterized by progressive muscle atrophy, weakness, and degeneration, is due to mutations in GNE, a gene encoding a bifunctional enzyme critical in sialic acid biosynthesis.	N-Acetylneuraminic Acid	236-247	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	181-184
22262892-6	2012	The opsonin C1q was binding to neurites after enzymatic removal of sialic acid residues from the neuronal glycocalyx.	N-Acetylneuraminic Acid	67-78	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	12-15
22262892-9	2012	Data demonstrate that mouse microglial cells via CR3 recognize and remove neuronal structures with an altered neuronal glycocalyx lacking terminal sialic acid.	N-Acetylneuraminic Acid	147-158	integrin alpha M	Mus musculus	49-52
21990163-2	2012	Sialic acid derivatives, already known to bind with high affinity to myelin-associated glycoprotein (MAG, Siglec-4), were screened for their binding affinity for CD22 by surface plasmon resonance.	N-Acetylneuraminic Acid	0-11	myelin associated glycoprotein	Homo sapiens	69-99
22566885-3	2011	Two members of the Siglec (sialic acid-binding immunoglobulin-like lectin) family, CD22 and Siglec-G have been shown to inhibit the BCR signal.	N-Acetylneuraminic Acid	27-38	CD22 molecule	Homo sapiens	83-87
22566885-3	2011	Two members of the Siglec (sialic acid-binding immunoglobulin-like lectin) family, CD22 and Siglec-G have been shown to inhibit the BCR signal.	N-Acetylneuraminic Acid	27-38	BCR activator of RhoGEF and GTPase	Homo sapiens	132-135
21990163-2	2012	Sialic acid derivatives, already known to bind with high affinity to myelin-associated glycoprotein (MAG, Siglec-4), were screened for their binding affinity for CD22 by surface plasmon resonance.	N-Acetylneuraminic Acid	0-11	myelin associated glycoprotein	Homo sapiens	101-104
21990163-2	2012	Sialic acid derivatives, already known to bind with high affinity to myelin-associated glycoprotein (MAG, Siglec-4), were screened for their binding affinity for CD22 by surface plasmon resonance.	N-Acetylneuraminic Acid	0-11	CD22 molecule	Homo sapiens	162-166
23094142-4	2012	Several anti-influenza drugs such as oseltamivir and zanamivir are derivatives of sialic acid, which inhibits neuraminidase.	N-Acetylneuraminic Acid	82-93	neuraminidase 1	Homo sapiens	110-123
22377735-0	2012	Assessment of sialic acid diversity in cancer- and non-cancer related CA125 antigen using sialic acid-binding Ig-like lectins (Siglecs).	N-Acetylneuraminic Acid	90-101	mucin 16, cell surface associated	Homo sapiens	70-75
22377735-0	2012	Assessment of sialic acid diversity in cancer- and non-cancer related CA125 antigen using sialic acid-binding Ig-like lectins (Siglecs).	N-Acetylneuraminic Acid	14-25	mucin 16, cell surface associated	Homo sapiens	70-75
22768242-3	2012	Levels of the ganglioside GM3, one of the most primitive glycosphingolipids containing a sialic acid in the structure, are remarkably decreased in the synovium of patients with RA.	N-Acetylneuraminic Acid	89-100	granulocyte macrophage antigen 3	Mus musculus	26-29
22072785-5	2012	However, favorable interactions beyond the sialic acid are found only for alpha2-6-linked glycans and are mediated by Asp190 and Asp225, which hydrogen bond with Gal-2 and GlcNAc-3.	N-Acetylneuraminic Acid	43-54	immunoglobulin binding protein 1	Homo sapiens	74-82
22072785-5	2012	However, favorable interactions beyond the sialic acid are found only for alpha2-6-linked glycans and are mediated by Asp190 and Asp225, which hydrogen bond with Gal-2 and GlcNAc-3.	N-Acetylneuraminic Acid	43-54	galectin 2	Homo sapiens	162-167
23028967-1	2012	Influenza virus neuraminidase (NA) cleaves terminal sialic acid residues on oligosaccharide chains that are receptors for virus binding, thus playing an important role in the release of virions from infected cells to promote the spread of cell-to-cell infection.	N-Acetylneuraminic Acid	52-63	neuraminidase 1	Homo sapiens	16-29
22844530-0	2012	Plant lectin can target receptors containing sialic acid, exemplified by podoplanin, to inhibit transformed cell growth and migration.	N-Acetylneuraminic Acid	45-56	podoplanin	Homo sapiens	73-83
22844530-8	2012	We report here that a lectin from the seeds of Maackia amurensis (MASL) with affinity for O-linked carbohydrate chains containing sialic acid targets PDPN to inhibit transformed cell growth and motility at nanomolar concentrations.	N-Acetylneuraminic Acid	130-141	podoplanin	Homo sapiens	150-154
22723922-1	2012	Sialoadhesin (Sn, Siglec-1, CD169) is a member of the sialic acid binding Ig-like lectin (siglec) family expressed on macrophages.	N-Acetylneuraminic Acid	54-65	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	0-12
22723922-1	2012	Sialoadhesin (Sn, Siglec-1, CD169) is a member of the sialic acid binding Ig-like lectin (siglec) family expressed on macrophages.	N-Acetylneuraminic Acid	54-65	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	14-16
22723922-1	2012	Sialoadhesin (Sn, Siglec-1, CD169) is a member of the sialic acid binding Ig-like lectin (siglec) family expressed on macrophages.	N-Acetylneuraminic Acid	54-65	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	18-26
22723922-1	2012	Sialoadhesin (Sn, Siglec-1, CD169) is a member of the sialic acid binding Ig-like lectin (siglec) family expressed on macrophages.	N-Acetylneuraminic Acid	54-65	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	28-33
22675478-5	2012	Significantly, the increased amount of sialic acid residues was primarily found in the Fab region whereas only a minor increase was observed in the Fc region.	N-Acetylneuraminic Acid	39-50	FA complementation group B	Homo sapiens	87-90
22675478-6	2012	This indicates preferential binding of the Fab sialic acid to SNA.	N-Acetylneuraminic Acid	47-58	FA complementation group B	Homo sapiens	43-46
22675478-10	2012	10%) of highly sialylated IgG, wherein the sialic acid is mainly found in the Fab region.	N-Acetylneuraminic Acid	43-54	FA complementation group B	Homo sapiens	78-81
23271952-6	2012	Here we show that the sialic acid-binding Ig-like lectin 1 (Siglec-1, CD169), which is highly expressed on mature DCs, specifically binds HIV-1 and vesicles carrying sialyllactose.	N-Acetylneuraminic Acid	22-33	sialic acid binding Ig like lectin 1	Homo sapiens	60-68
22013074-2	2011	The putative surface-exposed N-acetylhexosaminidase StrH/Spr0057 from Streptococcus pneumoniae R6 was proved to contribute to the virulence by removal of beta(1,2)-linked NAG on host defense molecules following the cleavage of sialic acid and galactose by neuraminidase and beta-galactosidase, respectively.	N-Acetylneuraminic Acid	227-238	strH	Streptococcus pneumoniae R6	52-56
22615821-5	2012	We have previously shown that human NKp46 recognizes viral hemagglutinin (HA) in a sialic acid-dependent manner and that the O-glycosylation is essential for the NKp46 binding to viral HA.	N-Acetylneuraminic Acid	83-94	natural cytotoxicity triggering receptor 1	Homo sapiens	36-41
22615821-7	2012	We show that Ncr1 recognizes influenza virus in a sialic acid dependent manner and that N-glycosylation is important for this binding.	N-Acetylneuraminic Acid	50-61	natural cytotoxicity triggering receptor 1	Mus musculus	13-17
22253810-0	2012	Glycoprotein hyposialylation gives rise to a nephrotic-like syndrome that is prevented by sialic acid administration in GNE V572L point-mutant mice.	N-Acetylneuraminic Acid	90-101	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	120-123
23196566-0	2012	[Sialic acid supplementation therapy for distal myopathy with rimmed vacuoles (GNE myopathy)].	N-Acetylneuraminic Acid	1-12	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	79-82
23196566-2	2012	The disease is caused by mutations, mostly missense, in GNE gene that encodes a protein with two enzymatic activities in sialic acid biosynthetic pathway: UDP-GlcNAc 2-epimerase and ManNAc kinase.	N-Acetylneuraminic Acid	121-132	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	56-59
23196566-2	2012	The disease is caused by mutations, mostly missense, in GNE gene that encodes a protein with two enzymatic activities in sialic acid biosynthetic pathway: UDP-GlcNAc 2-epimerase and ManNAc kinase.	N-Acetylneuraminic Acid	121-132	renin binding protein	Homo sapiens	159-177
22496731-11	2012	We conclude that (1) sialyl residues on TLR4 modulate LPS responsiveness, perhaps by facilitating clustering of the homodimers, and that (2) sialic acid, and perhaps other glycosyl species, regulate MD2 activity required for LPS-mediated signaling.	N-Acetylneuraminic Acid	141-152	lymphocyte antigen 96	Homo sapiens	199-202
23236285-11	2012	Both terminal sugar moieties of the GM2 glycan, N-acetylneuraminic acid and N-acetylgalactosamine, form contacts with the protein, providing an explanation for the observed specificity for GM2.	N-Acetylneuraminic Acid	48-71	cytochrome b5 domain containing 2	Mus musculus	36-39
23236285-11	2012	Both terminal sugar moieties of the GM2 glycan, N-acetylneuraminic acid and N-acetylgalactosamine, form contacts with the protein, providing an explanation for the observed specificity for GM2.	N-Acetylneuraminic Acid	48-71	cytochrome b5 domain containing 2	Mus musculus	189-192
22013074-2	2011	The putative surface-exposed N-acetylhexosaminidase StrH/Spr0057 from Streptococcus pneumoniae R6 was proved to contribute to the virulence by removal of beta(1,2)-linked NAG on host defense molecules following the cleavage of sialic acid and galactose by neuraminidase and beta-galactosidase, respectively.	N-Acetylneuraminic Acid	227-238	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	154-162
22013074-2	2011	The putative surface-exposed N-acetylhexosaminidase StrH/Spr0057 from Streptococcus pneumoniae R6 was proved to contribute to the virulence by removal of beta(1,2)-linked NAG on host defense molecules following the cleavage of sialic acid and galactose by neuraminidase and beta-galactosidase, respectively.	N-Acetylneuraminic Acid	227-238	bgaA	Streptococcus pneumoniae R6	274-292
22102160-9	2011	Neuraminidase was used to determine total glycan content of the low-abundance glycans containing sialic acid.	N-Acetylneuraminic Acid	97-108	neuraminidase 1	Homo sapiens	0-13
21913655-2	2011	Recently, we found that mammalian sialyltransferase ST3Gal-II can catalyze the formation of CMP-NeuAc from 5"-CMP in the presence of a donor containing the NeuAcalpha2,3Galbeta1,3GalNAc unit [Chandrasekaran, E. V., et al.	N-Acetylneuraminic Acid	96-101	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	52-61
22180208-6	2011	Neuraminidase treatment led to reduction of binding to sialic acid-binding lectins.	N-Acetylneuraminic Acid	55-66	neuraminidase 1	Homo sapiens	0-13
21919466-0	2011	DmSAS is required for sialic acid biosynthesis in cultured Drosophila third instar larvae CNS neurons.	N-Acetylneuraminic Acid	22-33	N-acetylneuraminic acid synthase	Drosophila melanogaster	0-5
21919466-3	2011	Here we investigated whether sialic acid incorporation in cultured Dm central nervous system (CNS) neurons required endogenously expressed Dm sialic acid synthase (DmSAS).	N-Acetylneuraminic Acid	29-40	N-acetylneuraminic acid synthase	Drosophila melanogaster	142-162
21919466-3	2011	Here we investigated whether sialic acid incorporation in cultured Dm central nervous system (CNS) neurons required endogenously expressed Dm sialic acid synthase (DmSAS).	N-Acetylneuraminic Acid	29-40	N-acetylneuraminic acid synthase	Drosophila melanogaster	164-169
22041858-8	2011	The investigation of the influence of sialic acid in the carbohydrate chain of human serum Tf, studied by incubating the protein with neuraminidase (sialidase) to obtain the monosialilated species, revealed that the binding affinity of Ti was similar for monosialo-Tf and for native-Tf and occurs in the N-lobe.	N-Acetylneuraminic Acid	38-49	transferrin	Homo sapiens	91-93
22041858-8	2011	The investigation of the influence of sialic acid in the carbohydrate chain of human serum Tf, studied by incubating the protein with neuraminidase (sialidase) to obtain the monosialilated species, revealed that the binding affinity of Ti was similar for monosialo-Tf and for native-Tf and occurs in the N-lobe.	N-Acetylneuraminic Acid	38-49	neuraminidase 1	Homo sapiens	134-147
22041858-8	2011	The investigation of the influence of sialic acid in the carbohydrate chain of human serum Tf, studied by incubating the protein with neuraminidase (sialidase) to obtain the monosialilated species, revealed that the binding affinity of Ti was similar for monosialo-Tf and for native-Tf and occurs in the N-lobe.	N-Acetylneuraminic Acid	38-49	transferrin	Homo sapiens	265-267
22041858-8	2011	The investigation of the influence of sialic acid in the carbohydrate chain of human serum Tf, studied by incubating the protein with neuraminidase (sialidase) to obtain the monosialilated species, revealed that the binding affinity of Ti was similar for monosialo-Tf and for native-Tf and occurs in the N-lobe.	N-Acetylneuraminic Acid	38-49	transferrin	Homo sapiens	265-267
21913655-4	2011	This study shows by using [9-(3)H]- or [(14)C]sialyl mucin core 2 compounds that ST3Gal-II exchanges sialyl residues between CMP-NeuAc and the NeuAcalpha2,3Galbeta1,3GalNAc unit and also radiolabels sialyl residues in gangliosides GD1a and GT1b, but not GM1.	N-Acetylneuraminic Acid	129-134	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	81-90
21885482-3	2011	The aim of this work was to assess the influence of the NanH sialidase on initial biofilm adhesion and growth in experiments where the only source of sialic acid was sialoglycoproteins or human oral secretions.	N-Acetylneuraminic Acid	150-161	neuraminidase 1	Homo sapiens	56-60
21620373-1	2011	OBJECTIVE: Sialin has been identified as a sialic acid and aspartate/glutamate transporter.	N-Acetylneuraminic Acid	43-54	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	11-17
21890341-0	2011	Enzymatic synthesis of sialic acid derivative by immobilized lipase from Candida antarctica.	N-Acetylneuraminic Acid	23-34	PAN0_003d1715	Moesziomyces antarcticus	61-67
21890341-1	2011	The effects of important reaction parameters on the enhancement of sialic acid derivative lipophilic properties through the lipase-catalyzed esterification of N-acetyl neuraminic acid methyl ester are investigated in this study.	N-Acetylneuraminic Acid	67-78	PAN0_003d1715	Moesziomyces antarcticus	124-130
21880775-6	2011	Finally, binding competition experiments using a library of mono- and oligosaccharides mimicking known PSGL-1 glycans suggested that CVA24v binds to Neu5Acalpha2,3Gal disaccharides (Neu5Ac is N-acetylneuraminic acid).	N-Acetylneuraminic Acid	149-155	selectin P ligand	Homo sapiens	103-109
21885482-7	2011	In addition, the ability of the nanH mutant to form biofilms on glycoprotein-coated surfaces could be restored by the addition of purified NanH, which we show is able to cleave sialic acid from the model glycoprotein fetuin and, much less efficiently, 9-O-acetylated bovine submaxillary mucin.	N-Acetylneuraminic Acid	177-188	neuraminidase 1	Homo sapiens	32-36
21885482-7	2011	In addition, the ability of the nanH mutant to form biofilms on glycoprotein-coated surfaces could be restored by the addition of purified NanH, which we show is able to cleave sialic acid from the model glycoprotein fetuin and, much less efficiently, 9-O-acetylated bovine submaxillary mucin.	N-Acetylneuraminic Acid	177-188	neuraminidase 1	Homo sapiens	139-143
21885482-7	2011	In addition, the ability of the nanH mutant to form biofilms on glycoprotein-coated surfaces could be restored by the addition of purified NanH, which we show is able to cleave sialic acid from the model glycoprotein fetuin and, much less efficiently, 9-O-acetylated bovine submaxillary mucin.	N-Acetylneuraminic Acid	177-188	mucin 1, cell surface associated	Bos taurus	287-292
21922291-1	2011	Zanamivir is the known potent anti-influenza agent targeting the key enzyme neuraminidase that cleaves sialic acid from cell receptors allowing release of newly formed virions.	N-Acetylneuraminic Acid	103-114	neuraminidase 1	Homo sapiens	76-89
21859949-7	2011	Resistant CEM/dEpoB cells had a significant decrease of alpha2-6 linked sialic acid on N-glycans.	N-Acetylneuraminic Acid	72-83	immunoglobulin binding protein 1	Homo sapiens	56-64
21870866-0	2011	Correlation analyses on binding affinity of sialic acid analogues and anti-influenza drugs with human neuraminidase using ab initio MO calculations on their complex structures--LERE-QSAR analysis (IV).	N-Acetylneuraminic Acid	44-55	neuraminidase 1	Homo sapiens	102-115
21880722-10	2011	The binding of GdA to Siglec-6 was sialic acid-dependent.	N-Acetylneuraminic Acid	35-46	progestagen associated endometrial protein	Homo sapiens	15-18
21880722-10	2011	The binding of GdA to Siglec-6 was sialic acid-dependent.	N-Acetylneuraminic Acid	35-46	sialic acid binding Ig like lectin 6	Homo sapiens	22-30
21870866-3	2011	LERE-QSAR analysis quantitatively revealed that the complex formation is driven by hydrogen-bonding and electrostatic interaction of hNEU2 with sialic acid analogues.	N-Acetylneuraminic Acid	144-155	neuraminidase 2	Homo sapiens	133-138
21859137-2	2011	The syntheses were accomplished through either the direct attachment of the sialic acid carboxyl group to amine-terminated PAMAM (a divergent-like approach) using BOP coupling, or by first reacting sialic acid with a polar bifunctional spacer molecule, attaching the sugar-linker to carboxy-terminated PAMAM (a convergent-like approach), and again using BOP-mediated coupling reactions.	N-Acetylneuraminic Acid	76-87	BOP	Homo sapiens	163-166
21910480-1	2011	UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) catalyzes the first two committed steps in sialic acid synthesis.	N-Acetylneuraminic Acid	86-97	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	38-41
21945320-2	2011	The Kv3.1 glycoprotein, a neuronal voltage-gated potassium channel, contains sialic acid.	N-Acetylneuraminic Acid	77-88	potassium voltage-gated channel subfamily C member 1	Homo sapiens	4-9
21835922-6	2011	Siglec-E bound a wide range of sialylated structures in glycan arrays, had a preference for NeuAc versus NeuGc-terminated sequences and could recognize a set of sialoglycoproteins that included CD45, in lysates from activated T-lymphocytes.	N-Acetylneuraminic Acid	92-97	sialic acid binding Ig-like lectin E	Mus musculus	0-8
21838327-4	2011	In this study, multivalent sialic acid constructs based on 10,12-pentacosadiynoic acid (PDA) have been synthesized, and these constructs are shown to be efficient inhibitors of Ad binding (IC(50) = 0.9 muM) and Ad infectivity (IC(50) = 0.7 muM).	N-Acetylneuraminic Acid	27-38	latexin	Homo sapiens	202-205
21838327-4	2011	In this study, multivalent sialic acid constructs based on 10,12-pentacosadiynoic acid (PDA) have been synthesized, and these constructs are shown to be efficient inhibitors of Ad binding (IC(50) = 0.9 muM) and Ad infectivity (IC(50) = 0.7 muM).	N-Acetylneuraminic Acid	27-38	latexin	Homo sapiens	240-243
21781115-1	2011	Sialin, the protein coded by SLC17A5, is responsible for membrane potential (Deltapsi)-driven aspartate and glutamate transport into synaptic vesicles in addition to H+/sialic acid co-transport in lysosomes.	N-Acetylneuraminic Acid	169-180	solute carrier family 17 member 5	Homo sapiens	0-6
21892771-0	2011	Lectin affinity chromatography of articular cartilage fibromodulin: Some molecules have keratan sulphate chains exclusively capped by alpha(2-3)-linked sialic acid.	N-Acetylneuraminic Acid	152-163	fibromodulin	Bos taurus	54-66
21892771-2	2011	It has been confirmed that the keratan sulphate chains attached to fibromodulin isolated from bovine articular cartilage may have the chain terminating N-acetylneuraminic acid residue alpha(2-3)- or alpha(2-6)-linked to the adjacent galactose residue.	N-Acetylneuraminic Acid	152-175	fibromodulin	Bos taurus	67-79
21892771-6	2011	The remainder of the fibromodulin proteoglycans, which bound to the lectin had a mixture of alpha(2-3)- and alpha(2-6)-linked N-acetylneuraminic acid capping structures.	N-Acetylneuraminic Acid	126-149	fibromodulin	Bos taurus	21-33
21663560-3	2011	Since samples from alcoholic patients are characterized by decreased sialic acid content in serum transferrin, the assessment of CDT is thereby widely used for laboratory evaluation of chronic alcohol abuse.	N-Acetylneuraminic Acid	69-80	transferrin	Homo sapiens	98-109
21781115-1	2011	Sialin, the protein coded by SLC17A5, is responsible for membrane potential (Deltapsi)-driven aspartate and glutamate transport into synaptic vesicles in addition to H+/sialic acid co-transport in lysosomes.	N-Acetylneuraminic Acid	169-180	solute carrier family 17 member 5	Homo sapiens	29-36
21781115-4	2011	Proteoliposomes containing purified heterologously expressed human sialin exhibited both Deltapsi-driven aspartate and glutamate transport activity and H+/sialic acid co-transport activity.	N-Acetylneuraminic Acid	155-166	solute carrier family 17 member 5	Homo sapiens	67-73
21781115-6	2011	In contrast, SLC17A5 protein harboring the mutations associated with infantile sialic acid storage disease, H183R and Delta268SSLRN272 still showed normal levels of Deltapsi-driven aspartate and glutamate transport even though H+/sialic acid co-transport activity was absent.	N-Acetylneuraminic Acid	79-90	solute carrier family 17 member 5	Homo sapiens	13-20
21781115-6	2011	In contrast, SLC17A5 protein harboring the mutations associated with infantile sialic acid storage disease, H183R and Delta268SSLRN272 still showed normal levels of Deltapsi-driven aspartate and glutamate transport even though H+/sialic acid co-transport activity was absent.	N-Acetylneuraminic Acid	230-241	solute carrier family 17 member 5	Homo sapiens	13-20
21970996-2	2011	Sialic acid-binding immunoglobulin-like lectin (Siglec-F) is a receptor highly expressed on mouse eosinophils and mediates eosinophilic apoptosis.	N-Acetylneuraminic Acid	0-11	sialic acid binding Ig-like lectin F	Mus musculus	48-56
20488687-0	2011	Absence of hematological side effects in acute and subacute nasal dosing of erythropoietin with a low content of sialic acid.	N-Acetylneuraminic Acid	113-124	erythropoietin	Rattus norvegicus	76-90
21795693-9	2011	Taken together, we have identified and isolated the first microbial non-sialic acid Siglec-binding region that can be used as a tool in studies of the beta/hSiglec-5 interaction.	N-Acetylneuraminic Acid	72-83	sialic acid binding Ig like lectin 5	Homo sapiens	156-165
21838313-6	2011	Diazirine-modified sialic acid analogues could be incorporated into both alpha2-3 and alpha2-6 linkages.	N-Acetylneuraminic Acid	19-30	immunoglobulin binding protein 1	Homo sapiens	86-94
21561770-1	2011	Myelin associated glycoprotein (Siglec-4) is a myelin adhesion receptor, that is, well established for its role as an inhibitor of axonal outgrowth in nerve injury, mediated by binding to sialic acid containing ligands on the axonal membrane.	N-Acetylneuraminic Acid	188-199	myelin associated glycoprotein	Homo sapiens	0-30
21288691-7	2011	RESULTS: Total lipid-bound sialic acid of human milk gangliosides after preterm delivery showed a peak concentration at 2 to 3 d postpartum and then remained at a high concentration until approximately 10 d. GD3 was the major ganglioside in the colostrum until approximately 7 to 10 d postpartum.	N-Acetylneuraminic Acid	27-38	GRDX	Homo sapiens	208-211
21480363-6	2011	Secondary screening in the presence of a neuraminidase inhibitor (4-deoxy-4-guanidino-Neu5Ac2en) significantly reduced sialic acid binding.	N-Acetylneuraminic Acid	119-130	neuraminidase 1	Homo sapiens	41-54
21507905-9	2011	This balance between enzymes of sialic acid metabolism may explain the strong overall staining intensity for all GD3 forms in T cells.	N-Acetylneuraminic Acid	32-43	GRDX	Homo sapiens	113-116
21507905-10	2011	Both CASD1, presumably encoding a sialic acid-specific O-acetyltransferase, and H-Lse showed highest transcription in peripheral B lymphocytes corresponding to the low expression of CD60b and c in these cells.	N-Acetylneuraminic Acid	34-45	CAS1 domain containing 1	Homo sapiens	5-10
21507905-10	2011	Both CASD1, presumably encoding a sialic acid-specific O-acetyltransferase, and H-Lse showed highest transcription in peripheral B lymphocytes corresponding to the low expression of CD60b and c in these cells.	N-Acetylneuraminic Acid	34-45	sialic acid acetylesterase	Homo sapiens	80-85
21807667-2	2011	Normally a buildup of GD3 induces apoptosis, but this does not occur in gliomas due to formation of 9-O-acetyl GD3 by the addition of an acetyl group to the terminal sialic acid of GD3; this renders GD3 unable to induce apoptosis.	N-Acetylneuraminic Acid	166-177	GRDX	Homo sapiens	111-114
21253856-6	2011	The content of total sialic acid and levels of gangliosides GM3, GM2, and GD3 were greater in the whole brains of Idua-/- mice then in Idua (+/?)	N-Acetylneuraminic Acid	21-32	iduronidase, alpha-L	Mus musculus	114-118
21807667-2	2011	Normally a buildup of GD3 induces apoptosis, but this does not occur in gliomas due to formation of 9-O-acetyl GD3 by the addition of an acetyl group to the terminal sialic acid of GD3; this renders GD3 unable to induce apoptosis.	N-Acetylneuraminic Acid	166-177	GRDX	Homo sapiens	111-114
21807667-2	2011	Normally a buildup of GD3 induces apoptosis, but this does not occur in gliomas due to formation of 9-O-acetyl GD3 by the addition of an acetyl group to the terminal sialic acid of GD3; this renders GD3 unable to induce apoptosis.	N-Acetylneuraminic Acid	166-177	GRDX	Homo sapiens	111-114
21229239-3	2011	In this study, normal THP was treated with neuraminidase to remove sialic acid residues, confirmed by an isoelectric point shift to higher pH.	N-Acetylneuraminic Acid	67-78	neuraminidase 1	Homo sapiens	43-56
21436238-4	2011	The enzyme GNE (uridine diphosphate-N-acetyl glucosamine 2-epimerase)/MNK (N-acetyl mannosamine kinase), which plays a key role in the initial two steps of sialic acid biosynthesis, is regulated by cytidine monophosphate (CMP)-sialic acid through a feedback mechanism.	N-Acetylneuraminic Acid	156-167	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	Cricetulus griseus	11-14
21436238-4	2011	The enzyme GNE (uridine diphosphate-N-acetyl glucosamine 2-epimerase)/MNK (N-acetyl mannosamine kinase), which plays a key role in the initial two steps of sialic acid biosynthesis, is regulated by cytidine monophosphate (CMP)-sialic acid through a feedback mechanism.	N-Acetylneuraminic Acid	156-167	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	Cricetulus griseus	45-68
21436238-4	2011	The enzyme GNE (uridine diphosphate-N-acetyl glucosamine 2-epimerase)/MNK (N-acetyl mannosamine kinase), which plays a key role in the initial two steps of sialic acid biosynthesis, is regulated by cytidine monophosphate (CMP)-sialic acid through a feedback mechanism.	N-Acetylneuraminic Acid	156-167	ATPase copper transporting alpha	Rattus norvegicus	70-73
21436238-4	2011	The enzyme GNE (uridine diphosphate-N-acetyl glucosamine 2-epimerase)/MNK (N-acetyl mannosamine kinase), which plays a key role in the initial two steps of sialic acid biosynthesis, is regulated by cytidine monophosphate (CMP)-sialic acid through a feedback mechanism.	N-Acetylneuraminic Acid	227-238	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	Cricetulus griseus	11-14
21436238-4	2011	The enzyme GNE (uridine diphosphate-N-acetyl glucosamine 2-epimerase)/MNK (N-acetyl mannosamine kinase), which plays a key role in the initial two steps of sialic acid biosynthesis, is regulated by cytidine monophosphate (CMP)-sialic acid through a feedback mechanism.	N-Acetylneuraminic Acid	227-238	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	Cricetulus griseus	45-68
21436238-4	2011	The enzyme GNE (uridine diphosphate-N-acetyl glucosamine 2-epimerase)/MNK (N-acetyl mannosamine kinase), which plays a key role in the initial two steps of sialic acid biosynthesis, is regulated by cytidine monophosphate (CMP)-sialic acid through a feedback mechanism.	N-Acetylneuraminic Acid	227-238	ATPase copper transporting alpha	Rattus norvegicus	70-73
21436238-8	2011	CMP-sialic acid concentration of engineered cells was significantly (&gt;10-fold) increased by sialuria-mutated GNE/MNK (R263L-R266Q) expression.	N-Acetylneuraminic Acid	4-15	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	Cricetulus griseus	112-115
21436238-8	2011	CMP-sialic acid concentration of engineered cells was significantly (&gt;10-fold) increased by sialuria-mutated GNE/MNK (R263L-R266Q) expression.	N-Acetylneuraminic Acid	4-15	ATPase copper transporting alpha	Rattus norvegicus	116-119
21436238-11	2011	These findings indicate that sialuria-mutated rat GNE/MNK effectively increases the intracellular CMP-sialic acid level.	N-Acetylneuraminic Acid	102-113	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	50-53
21436238-11	2011	These findings indicate that sialuria-mutated rat GNE/MNK effectively increases the intracellular CMP-sialic acid level.	N-Acetylneuraminic Acid	102-113	ATPase copper transporting alpha	Rattus norvegicus	54-57
21550977-1	2011	The glycosyltransferase, ST6Gal-I, adds sialic acid in an alpha2-6 linkage to the N-glycans of membrane and secreted glycoproteins.	N-Acetylneuraminic Acid	40-51	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	25-33
21712440-6	2011	The Tyr10 linked O-glycans were (Neu5Ac)(1-2)Hex(Neu5Ac)HexNAc-O- structures with the disialylated terminals occasionally O-acetylated or lactonized, indicating a terminal Neu5Acalpha2,8Neu5Ac linkage.	N-Acetylneuraminic Acid	33-39	hematopoietically expressed homeobox	Homo sapiens	45-48
21550977-1	2011	The glycosyltransferase, ST6Gal-I, adds sialic acid in an alpha2-6 linkage to the N-glycans of membrane and secreted glycoproteins.	N-Acetylneuraminic Acid	40-51	immunoglobulin binding protein 1	Homo sapiens	58-66
21584309-2	2011	Here we present that stable knock-down of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme in the sialic acid biosynthetic pathway, dramatically increases incorporation of N-acetylmannosamine analogues into glycoproteins of HEK293 cells.	N-Acetylneuraminic Acid	134-145	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	42-104
21584309-2	2011	Here we present that stable knock-down of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme in the sialic acid biosynthetic pathway, dramatically increases incorporation of N-acetylmannosamine analogues into glycoproteins of HEK293 cells.	N-Acetylneuraminic Acid	134-145	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	106-109
21350118-4	2011	The CMAH enzyme catalyzes the generation of CMP-Neu5Gc by the transfer of a single oxygen atom to the acyl group of CMP-Neu5Ac.	N-Acetylneuraminic Acid	120-126	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	4-8
21586272-0	2011	Siglec-15, a member of the sialic acid-binding lectin, is a novel regulator for osteoclast differentiation.	N-Acetylneuraminic Acid	27-38	sialic acid binding Ig-like lectin 15	Mus musculus	0-9
21419829-6	2011	The staining pattern of the antibody specific for polysialic acid (a linear homopolymer of alpha-2,8-linked sialic acid) increased in the CA1 and DG subfields of the Hp of the Abeta((25-35)) group compared to the control group.	N-Acetylneuraminic Acid	54-65	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	91-98
21278227-10	2011	The unique ability of HIM3-4 mAb to detect the masking state of CD33 on different cell lineages makes it a good tool to improve the knowledge of the biological role of this sialic acid-binding Ig-like lectin.	N-Acetylneuraminic Acid	173-184	CD33 molecule	Homo sapiens	64-68
21953046-4	2011	With structures containing sialic acid on both the C-3 and C-6 branch, the [M - H](-) ions were dominated by the loss of sialic acid.	N-Acetylneuraminic Acid	27-38	complement C3	Homo sapiens	51-54
21953046-4	2011	With structures containing sialic acid on both the C-3 and C-6 branch, the [M - H](-) ions were dominated by the loss of sialic acid.	N-Acetylneuraminic Acid	27-38	complement C6	Homo sapiens	59-62
21953046-4	2011	With structures containing sialic acid on both the C-3 and C-6 branch, the [M - H](-) ions were dominated by the loss of sialic acid.	N-Acetylneuraminic Acid	121-132	complement C3	Homo sapiens	51-54
21490156-5	2011	Removal of sialic acid from the single N-linked carbohydrate of the C-terminal domain of PTX3 abolished the interaction.	N-Acetylneuraminic Acid	11-22	pentraxin 3	Homo sapiens	89-93
21490156-6	2011	Likewise, an M-ficolin mutant with impaired sialic acid-binding ability did not interact with PTX3.	N-Acetylneuraminic Acid	44-55	ficolin 1	Homo sapiens	13-22
21334436-8	2011	These data demonstrate that darbepoetin alfa suppresses TNF-alpha-induced ET-1 production through its antioxidant action and suggest that the sialic acid residues of darbepoetin alfa are essential for its antioxidant effect, possibly by scavenging ROS.	N-Acetylneuraminic Acid	142-153	tumor necrosis factor	Homo sapiens	56-65
21419829-6	2011	The staining pattern of the antibody specific for polysialic acid (a linear homopolymer of alpha-2,8-linked sialic acid) increased in the CA1 and DG subfields of the Hp of the Abeta((25-35)) group compared to the control group.	N-Acetylneuraminic Acid	54-65	carbonic anhydrase 1	Rattus norvegicus	138-141
21220208-2	2011	hCSS synthesizes CMP-NeuAc, which hST uses as a donor substrate to transfer NeuAc to the terminal position of N-linked glycans.	N-Acetylneuraminic Acid	21-26	sulfotransferase family 2A member 1	Homo sapiens	34-37
20947662-0	2011	The human Cas1 protein: a sialic acid-specific O-acetyltransferase?	N-Acetylneuraminic Acid	26-37	BCAR1 scaffold protein, Cas family member	Homo sapiens	10-14
21508391-2	2011	Sialic acid is carried by fibronectin (sFN) as the antigen of monoclonal antibody (MoAb) JT-95 detected in 90% of PTC, and a few cases of FTC.	N-Acetylneuraminic Acid	0-11	fibronectin 1	Homo sapiens	26-37
21508391-2	2011	Sialic acid is carried by fibronectin (sFN) as the antigen of monoclonal antibody (MoAb) JT-95 detected in 90% of PTC, and a few cases of FTC.	N-Acetylneuraminic Acid	0-11	RNA exonuclease 2	Homo sapiens	39-42
21502513-5	2011	Here we investigate the role of erythrocyte-binding antigen 175 (EBA-175), a parasite ligand that binds to sialic acid on glycophorin A, in the invasion of erythrocytes by 10 P. falciparum clones under conditions in which invasion is partially limited to the EBA-175-glycophorin A pathway, using chymotrypsin-treated erythrocytes.	N-Acetylneuraminic Acid	107-118	erythrocyte binding antigen-175	Plasmodium falciparum 3D7	65-72
21502513-6	2011	We show that the ability to invade erythrocytes for both sialic acid-independent and sialic acid-dependent pathways requires the EBA-175-glycophorin A pathway for erythrocyte invasion.	N-Acetylneuraminic Acid	57-68	erythrocyte binding antigen-175	Plasmodium falciparum 3D7	129-136
21502513-6	2011	We show that the ability to invade erythrocytes for both sialic acid-independent and sialic acid-dependent pathways requires the EBA-175-glycophorin A pathway for erythrocyte invasion.	N-Acetylneuraminic Acid	85-96	erythrocyte binding antigen-175	Plasmodium falciparum 3D7	129-136
21478876-4	2011	Here we use an intestinal perforation model of sepsis to show that microbial sialidases target the sialic acid-based recognition of CD24 by SiglecG/10 to exacerbate inflammation.	N-Acetylneuraminic Acid	99-110	CD24a antigen	Mus musculus	132-136
21478876-4	2011	Here we use an intestinal perforation model of sepsis to show that microbial sialidases target the sialic acid-based recognition of CD24 by SiglecG/10 to exacerbate inflammation.	N-Acetylneuraminic Acid	99-110	sialic acid binding Ig-like lectin G	Mus musculus	140-147
21098517-3	2011	The sialyltransferase enzyme ST6Gal I transfers sialic acid from CMP-sialic acid to type 2 (Galbeta1,4GlcNAc) free disaccharides or the termini of N- or O-linked oligosaccharides using an alpha2,6-linkage.	N-Acetylneuraminic Acid	48-59	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	29-37
21098517-3	2011	The sialyltransferase enzyme ST6Gal I transfers sialic acid from CMP-sialic acid to type 2 (Galbeta1,4GlcNAc) free disaccharides or the termini of N- or O-linked oligosaccharides using an alpha2,6-linkage.	N-Acetylneuraminic Acid	69-80	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	29-37
21220208-2	2011	hCSS synthesizes CMP-NeuAc, which hST uses as a donor substrate to transfer NeuAc to the terminal position of N-linked glycans.	N-Acetylneuraminic Acid	76-81	sulfotransferase family 2A member 1	Homo sapiens	34-37
21220208-6	2011	In addition, CMP-NeuAc produced by hCSS in the transformed plant cells functioned as a donor substrate to hST.	N-Acetylneuraminic Acid	17-22	sulfotransferase family 2A member 1	Homo sapiens	106-109
21220208-7	2011	An in vitro coupled hCSS and hST reaction resulted in the production of mammalian-type sialoglycoproteins bearing terminal NeuAc residues.	N-Acetylneuraminic Acid	123-128	sulfotransferase family 2A member 1	Homo sapiens	29-32
21349726-0	2011	CD22-antagonists with nanomolar potency: the synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold.	N-Acetylneuraminic Acid	104-115	complement C9	Homo sapiens	97-100
21192254-1	2011	Fibrinogen has previously been demonstrated to exist in a "fetal" form, in cord blood of term infants, with increased sialic acid content compared to adult fibrinogen.	N-Acetylneuraminic Acid	118-129	fibrinogen beta chain	Homo sapiens	0-10
21349726-0	2011	CD22-antagonists with nanomolar potency: the synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold.	N-Acetylneuraminic Acid	104-115	CD22 molecule	Homo sapiens	0-4
21359217-3	2011	Originally, sialoadhesin was characterized as a lymphocyte adhesion molecule, though recently its involvement in internalization of sialic acid carrying pathogens was shown, suggesting that sialoadhesin is an endocytic receptor.	N-Acetylneuraminic Acid	132-143	sialic acid binding Ig like lectin 1	Homo sapiens	12-24
21148159-4	2011	The detection of augmented biosynthesis of endogenous sialylparagloboside indicated that [NeuAc][Hex]-GlcNAc was predicted to be the non-reducing end trisaccharide of sialylparagloboside.	N-Acetylneuraminic Acid	90-95	hematopoietically expressed homeobox	Mus musculus	97-100
21191006-0	2011	N-linked glycosylation facilitates sialic acid-independent attachment and entry of influenza A viruses into cells expressing DC-SIGN or L-SIGN.	N-Acetylneuraminic Acid	35-46	C-type lectin domain family 4 member M	Homo sapiens	136-142
21359217-3	2011	Originally, sialoadhesin was characterized as a lymphocyte adhesion molecule, though recently its involvement in internalization of sialic acid carrying pathogens was shown, suggesting that sialoadhesin is an endocytic receptor.	N-Acetylneuraminic Acid	132-143	sialic acid binding Ig like lectin 1	Homo sapiens	190-202
21359217-9	2011	Together, these data expand sialoadhesin functionality and show that it can function as an endocytic receptor, a feature that cannot only be misused by sialic acid carrying pathogens, but that may also be used for specific targeting of toxins or antigens to sialoadhesin-expressing macrophages.	N-Acetylneuraminic Acid	152-163	sialic acid binding Ig like lectin 1	Homo sapiens	28-40
20395633-7	2011	Thus, alpha2,3-linked sialic acid-containing glycoprotein Siglec-F ligands and the enzymes required for their synthesis are constitutively expressed in murine lungs, especially by airway epithelium.	N-Acetylneuraminic Acid	22-33	sialic acid binding Ig-like lectin F	Mus musculus	58-66
21291557-5	2011	To determine the average number of sialic acid attachments per N-glycosylation, we digested Dsp with glycopeptidase A, labeled the released N-glycosylations with 2-aminobenzoic acid, and quantified the moles of released glycosylations by comparison to labeled standards of known concentration.	N-Acetylneuraminic Acid	35-46	dentin sialophosphoprotein	Homo sapiens	92-95
21291557-10	2011	Dsp averages one sialic acid per N-glycosylation, which is always in the form of N-acetylneuraminic acid.	N-Acetylneuraminic Acid	17-28	dentin sialophosphoprotein	Homo sapiens	0-3
21291557-10	2011	Dsp averages one sialic acid per N-glycosylation, which is always in the form of N-acetylneuraminic acid.	N-Acetylneuraminic Acid	81-104	dentin sialophosphoprotein	Homo sapiens	0-3
22048274-0	2011	Fucose and sialic acid expressions in human seminal fibronectin and alpha{1} -acid glycoprotein associated with leukocytospermia of infertile men.	N-Acetylneuraminic Acid	11-22	fibronectin 1	Homo sapiens	52-63
20953868-2	2011	The enzyme neuraminidase was used to remove sialic acid residues from the cell glycocalyx.	N-Acetylneuraminic Acid	44-55	neuraminidase 1	Homo sapiens	11-24
21305017-2	2011	Although the causing gene, GNE, encodes for a key enzyme in the biosynthesis of sialic acid, its primary function in HIBM remains unknown.	N-Acetylneuraminic Acid	80-91	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	27-30
20962036-10	2011	4-aminopyridine, gaboxadol hydrochloride and N-acetylneuraminic acid all rescued at least one aspect of smn-1 phenotypic dysfunction.	N-Acetylneuraminic Acid	45-68	survival of motor neuron 1, telomeric	Homo sapiens	104-109
21224350-6	2011	Importantly, Lith-O-Asp decreased the sialic acid modification of integrin-beta1 and inhibited the expression of phospho-FAK, phospho-paxillin, and the matrix metalloprotease (MMP) 2 and MMP9.	N-Acetylneuraminic Acid	38-49	integrin subunit beta 1	Homo sapiens	66-80
22048274-1	2011	INTRODUCTION: The aim of this study was to compare fucose and sialic acid residue expression on fibronectin and alpha{1}-acid glycoprotein in the seminal plasma of men suspected of infertility and suffering from leukocytospermia.	N-Acetylneuraminic Acid	62-73	fibronectin 1	Homo sapiens	96-107
22048274-3	2011	The relative degree of fucosylation and sialylation of fibronectin and alpha{1}-acid glycoprotein was estimated by ELISA using fucose and sialic acid specific lectins from Aleuria aurantia, Lotus tetragonolobus, and Ulex europaeus as well as Maackia amurensis and Sambucus nigra, respectively.	N-Acetylneuraminic Acid	138-149	fibronectin 1	Homo sapiens	55-66
20978010-8	2011	All showed much lower activities than with the corresponding sialic acid substrate, with the influenza virus N1 being the most active and human NEU2 being the least active.	N-Acetylneuraminic Acid	61-72	neuraminidase 2	Homo sapiens	144-148
21161373-0	2011	Alterations of glycan branching and differential expression of sialic acid on alpha fetoprotein among hepatitis patients.	N-Acetylneuraminic Acid	63-74	alpha fetoprotein	Homo sapiens	78-95
22161838-7	2011	Finally, removal of sialic acid from both CMMT and CMT-U27 xenograft samples exposed galectin-3-ligands throughout the tumour tissue, whereas these ligands were only present in galectin-3-positive invading cells in untreated samples.	N-Acetylneuraminic Acid	20-31	galectin 3	Macaca mulatta	85-95
21957455-6	2011	Moreover, the mean serum half-life of EPO-hyFc(H), a high sialic acid content form of EPO-hyFc, was approximately 2-fold longer than that of the heavily glycosylated EPO, darbepoetin alfa, in rats.	N-Acetylneuraminic Acid	58-69	erythropoietin	Rattus norvegicus	38-41
22131812-4	2011	The elevated level of sialic-acid-containing glycoconjugate epitopes was due to the low level of alpha-Gal in heterozygote GalT KO livers.	N-Acetylneuraminic Acid	22-33	galactose-1-phosphate uridylyltransferase	Sus scrofa	123-127
21151138-9	2011	When we fed the sialic acid precursor N-acetyl-D-mannosamine (ManNAc) to NPHS2-Angptl4 transgenic rats it increased the sialylation of Angptl4 and decreased albuminuria by more than 40%.	N-Acetylneuraminic Acid	16-27	NPHS2 stomatin family member, podocin	Rattus norvegicus	73-78
21151138-9	2011	When we fed the sialic acid precursor N-acetyl-D-mannosamine (ManNAc) to NPHS2-Angptl4 transgenic rats it increased the sialylation of Angptl4 and decreased albuminuria by more than 40%.	N-Acetylneuraminic Acid	16-27	angiopoietin-like 4	Rattus norvegicus	79-86
21151138-9	2011	When we fed the sialic acid precursor N-acetyl-D-mannosamine (ManNAc) to NPHS2-Angptl4 transgenic rats it increased the sialylation of Angptl4 and decreased albuminuria by more than 40%.	N-Acetylneuraminic Acid	16-27	angiopoietin-like 4	Rattus norvegicus	135-142
22131812-3	2011	Enzyme-linked lectin assays indicated that there were also more sialic acid-containing glycoconjugate epitopes in GalT KO livers than in controls.	N-Acetylneuraminic Acid	64-75	galactose-1-phosphate uridylyltransferase	Sus scrofa	114-118
22131812-4	2011	The elevated level of sialic-acid-containing glycoconjugate epitopes was due to the low level of alpha-Gal in heterozygote GalT KO livers.	N-Acetylneuraminic Acid	22-33	GLA	Sus scrofa	97-106
22164239-1	2011	Using a lectin, Achatinin-H, having preferential specificity for glycoproteins with terminal 9-O-acetyl sialic acid derivatives linked in alpha2-6 linkages to subterminal N-acetylgalactosamine, eight distinct disease-associated 9-O-acetylated sialoglycoproteins was purified from erythrocytes of visceral leishmaniaisis (VL) patients (RBC(VL)).	N-Acetylneuraminic Acid	104-115	immunoglobulin binding protein 1	Homo sapiens	138-146
21931755-3	2011	METHODOLOGY AND PRINCIPAL FINDINGS: Using both solution and cell surface binding experiments, we showed that R5- and X4-tropic HIV-1 gp120 proteins recognized a family of I-type lectin receptors, the Sialic acid-binding immunoglobulin-like lectins (Siglec).	N-Acetylneuraminic Acid	200-211	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	133-138
21957465-1	2011	Polysialic acid (PSA) is a unique carbohydrate composed of a linear homopolymer of alpha-2,8 linked sialic acid, and is mainly attached to the fifth immunoglobulin-like domain of the neural cell adhesion molecule (NCAM) in vertebrate neural system.	N-Acetylneuraminic Acid	4-15	neural cell adhesion molecule 1	Mus musculus	183-212
21957465-1	2011	Polysialic acid (PSA) is a unique carbohydrate composed of a linear homopolymer of alpha-2,8 linked sialic acid, and is mainly attached to the fifth immunoglobulin-like domain of the neural cell adhesion molecule (NCAM) in vertebrate neural system.	N-Acetylneuraminic Acid	4-15	neural cell adhesion molecule 1	Mus musculus	214-218
21172065-9	2010	CONCLUSIONS: Low content of terminal GlcNac and sialic acid in peripheral ACT in AD patients suggests that a different pattern of glycosylation might be a marker of brain inflammation.	N-Acetylneuraminic Acid	48-59	serpin family A member 3	Homo sapiens	74-77
21922855-1	2011	BACKGROUND AND AIMS: Vibro cholera neuraminidase is known to cleave sialic acid in the gut to expose receptors for cholera enterotoxin.	N-Acetylneuraminic Acid	68-79	neuraminidase 1	Homo sapiens	35-48
21922855-2	2011	This study determined if cholera neuraminidase crosses significantly into the circulation of patients with cholera to cause cleavage of sialic acid on circulating blood cells.	N-Acetylneuraminic Acid	136-147	neuraminidase 1	Homo sapiens	33-46
21922855-3	2011	METHODS: Systemic cholera neuraminidase activity was determined by measuring serum sialic acid levels (thiobarbituric method) in 20 consecutive adult cholera patients (12 females, 8 males) with severe diarrhea before rehydration was commenced at Ahmadu Bello University Teaching Hospital, Zaria.	N-Acetylneuraminic Acid	83-94	neuraminidase 1	Homo sapiens	26-39
21922855-9	2011	CONCLUSION: This study indicates that neuraminidase may not reach the circulation in significant levels to contribute to significant cleavage of sialic acid on circulating blood cells of patients infected with Vibrio cholera serotype Hikojima.	N-Acetylneuraminic Acid	145-156	neuraminidase 1	Homo sapiens	38-51
21858186-1	2011	The influenza neuraminidase (NA) inhibitors zanamivir, oseltamivir and peramivir were all designed based on the knowledge that the transition state analogue of the cleaved sialic acid, 2-deoxy,2,3-dehydro N-acetyl neuraminic acid (DANA) was a weak inhibitor of NA.	N-Acetylneuraminic Acid	172-183	neuraminidase 1	Homo sapiens	14-27
21858186-1	2011	The influenza neuraminidase (NA) inhibitors zanamivir, oseltamivir and peramivir were all designed based on the knowledge that the transition state analogue of the cleaved sialic acid, 2-deoxy,2,3-dehydro N-acetyl neuraminic acid (DANA) was a weak inhibitor of NA.	N-Acetylneuraminic Acid	172-183	neuraminidase 1	Homo sapiens	29-31
21731727-1	2011	UDP-N-acetylglucosamine 2 epimerase/N-acetylmannosamime kinase (GNE) is a bifunctional enzyme which catalyzes the two key sequential steps in the biosynthetic pathway of sialic acid, the most abundant terminal monosaccharide on glycoconjugates of eukaryotic cells.	N-Acetylneuraminic Acid	170-181	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	64-67
20826611-1	2010	Removal of sialic acid from glycoconjugates on the surface of monocytes enhances their response to bacterial LPS.	N-Acetylneuraminic Acid	11-22	interferon regulatory factor 6	Homo sapiens	109-112
21248428-4	2010	In this study, thus, glycophorin A which is a highly glycosylated sialoglycoprotein with approximately 12 O-glycans was sequentially treated with sialidase and beta-galactosidase to remove sialic acid and galactose residues.	N-Acetylneuraminic Acid	189-200	glycophorin A (MNS blood group)	Homo sapiens	21-34
21248428-4	2010	In this study, thus, glycophorin A which is a highly glycosylated sialoglycoprotein with approximately 12 O-glycans was sequentially treated with sialidase and beta-galactosidase to remove sialic acid and galactose residues.	N-Acetylneuraminic Acid	189-200	galactosidase beta 1	Homo sapiens	160-178
20826611-10	2010	We conclude that sialidase-mediated change in sialic acid content of specific cell surface glycoconjugates in DCs regulates LPS-induced cytokine production, thereby contributing to development of adaptive immune responses.	N-Acetylneuraminic Acid	46-57	interferon regulatory factor 6	Homo sapiens	124-127
20521304-6	2010	As the fed-batch culture progressed, there was also an increase in less sialylated IFN-gamma glycoforms, leading to a 30% decrease in the molar ratio of sialic acid to recombinant IFN-gamma.	N-Acetylneuraminic Acid	153-164	interferon gamma	Homo sapiens	83-92
20663960-7	2010	In contrast, the sialic acid-binding site of Siglec-7 on NK cells was masked by cis interactions with endogenous sialoconjugates at the cell surface, but it could be unmasked by sialidase treatment of the NK cells.	N-Acetylneuraminic Acid	17-28	sialic acid binding Ig like lectin 7	Homo sapiens	45-53
20684967-1	2010	The PIV-5 hemagglutinin-neuraminidase (HN) protein is a multifunctional protein with sialic acid binding, neuraminidase and fusion promotion activity.	N-Acetylneuraminic Acid	85-96	neuraminidase 1	Homo sapiens	24-37
21103797-2	2010	Characterized by its low sialic acid content and therefore exhibiting a very short plasma half-life, Neuro-EPO can probably not be administered systemically via the blood.	N-Acetylneuraminic Acid	25-36	erythropoietin	Homo sapiens	107-110
21103798-5	2010	A promising approach has been recently developed with a nonerythropoietic variant of EPO, Neuro-EPO, with low sialic acid content, a very short plasma half-life, and without erythropoietic activity, probably similar to endogenous brain EPO.	N-Acetylneuraminic Acid	110-121	erythropoietin	Homo sapiens	85-88
21103798-5	2010	A promising approach has been recently developed with a nonerythropoietic variant of EPO, Neuro-EPO, with low sialic acid content, a very short plasma half-life, and without erythropoietic activity, probably similar to endogenous brain EPO.	N-Acetylneuraminic Acid	110-121	erythropoietin	Homo sapiens	90-99
20803237-0	2010	Cell surface sialic acid inhibits Cx43 gap junction functions in constructed Hela cancer cells involving in sialylated N-cadherin.	N-Acetylneuraminic Acid	13-24	gap junction protein alpha 1	Homo sapiens	34-38
20803237-0	2010	Cell surface sialic acid inhibits Cx43 gap junction functions in constructed Hela cancer cells involving in sialylated N-cadherin.	N-Acetylneuraminic Acid	13-24	cadherin 2	Homo sapiens	119-129
20803237-2	2010	In this paper, we investigated the effects of sialic acid on the Cx43 gap junction functions, and clarified its potential mechanisms thereby.	N-Acetylneuraminic Acid	46-57	gap junction protein alpha 1	Homo sapiens	65-69
20803237-3	2010	Sialidase significantly increased Cx43 gap junction functions in constructed Cx43-Hela cells along with down-regulation of cell surface sialic acid, which is dramatically reversed by sialidase inhibitor NeuAc2en.	N-Acetylneuraminic Acid	136-147	gap junction protein alpha 1	Homo sapiens	77-81
20803237-8	2010	Overall, these studies indicate cell surface sialic acid on cancer cells may suppress Cx43 gap junction functions via inhibiting Cx43 traffic to the plague involving in sialylated N-cadherin, a process that likely underlies the intimate association between abnormal GJIC and glycosylation on cancer development.	N-Acetylneuraminic Acid	45-56	gap junction protein alpha 1	Homo sapiens	86-90
20803237-8	2010	Overall, these studies indicate cell surface sialic acid on cancer cells may suppress Cx43 gap junction functions via inhibiting Cx43 traffic to the plague involving in sialylated N-cadherin, a process that likely underlies the intimate association between abnormal GJIC and glycosylation on cancer development.	N-Acetylneuraminic Acid	45-56	gap junction protein alpha 1	Homo sapiens	129-133
20803237-8	2010	Overall, these studies indicate cell surface sialic acid on cancer cells may suppress Cx43 gap junction functions via inhibiting Cx43 traffic to the plague involving in sialylated N-cadherin, a process that likely underlies the intimate association between abnormal GJIC and glycosylation on cancer development.	N-Acetylneuraminic Acid	45-56	cadherin 2	Homo sapiens	180-190
20800070-4	2010	Modeling of solvent-exposed surface electrostatic potentials showed that sialic acid imparts a significant negative surface charge that may influence gp120 antigenicity and immunogenicity.	N-Acetylneuraminic Acid	73-84	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	150-155
20800070-5	2010	Gp120 expressed in systems that do not incorporate sialic acid displayed increased ligand binding to the CD4 binding and CD4-induced sites compared to those expressed in the system that do, and imparted other more subtle differences in antigenicity in a gp120 subtype-specific manner.	N-Acetylneuraminic Acid	51-62	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	0-5
20800070-6	2010	Non-sialic-acid-containing gp120 was significantly more immunogenic than the sialylated version when administered in two different adjuvants, and induced higher titers of antibodies competing for CD4 binding site ligand-gp120 interaction.	N-Acetylneuraminic Acid	4-15	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	27-32
20800070-6	2010	Non-sialic-acid-containing gp120 was significantly more immunogenic than the sialylated version when administered in two different adjuvants, and induced higher titers of antibodies competing for CD4 binding site ligand-gp120 interaction.	N-Acetylneuraminic Acid	4-15	CD4 molecule	Homo sapiens	196-199
20800070-6	2010	Non-sialic-acid-containing gp120 was significantly more immunogenic than the sialylated version when administered in two different adjuvants, and induced higher titers of antibodies competing for CD4 binding site ligand-gp120 interaction.	N-Acetylneuraminic Acid	4-15	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	220-225
20800070-7	2010	These findings suggest that non-sialic-acid-imparting systems yield gp120 immunogens with modified antigenic and immunogenic properties, considerations that should be considered when selecting expression systems for glycosylated antigens to be used for structure-function studies and for vaccine use.	N-Acetylneuraminic Acid	32-43	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	68-73
20711574-5	2010	The surface-displayed recombinant NanH protein was expressed as a fully active sialidase and also transferred sialic acids from pNP-alpha-sialoside, a sialic acid donor substrate, to human-type asialo-N-glycans.	N-Acetylneuraminic Acid	110-121	neuraminidase 1	Homo sapiens	34-38
20930939-2	2010	Gangliosides, sialic acid-containing glycosphingolipids enriched in the nervous system and frequently used as biomarkers associated with the biochemical pathology of neurological disorders, have been suggested to be involved in the initial aggregation of Abeta.	N-Acetylneuraminic Acid	14-25	amyloid beta (A4) precursor protein	Mus musculus	255-260
20516366-1	2010	Among various mechanisms for interactions with B cells, intravenous immunoglobulin (IVIg) may operate through the insertion of its Fc part into the Fc-gamma receptor, or the binding of its sialic acid (SA)-bearing glycans to the negatively regulating CD22 lectin.	N-Acetylneuraminic Acid	202-204	CD22 molecule	Homo sapiens	251-255
20534593-3	2010	The sialyltransferase ST3Gal-I adds sialic acid to the galactose residue of core 1 (Galbeta1,3GalNAc) O-glycans and this enzyme is over-expressed in breast cancer resulting in the expression of sialylated core 1 glycans.	N-Acetylneuraminic Acid	36-47	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Mus musculus	22-30
20675684-8	2010	As this antibody is the first human anti-H5 scFv clearly defined on the sugar-binding epitope, it allows us to investigate the influence of amino acid substitutions in this region on the determination of the binding specificity to either sialic acid alpha2,6-galactose (SA alpha2,6Gal) or sialic acid alpha2,3-galactose (SA alpha2,3Gal) providing new insight for the development of effective H5N1 pandemic vaccines.	N-Acetylneuraminic Acid	238-249	immunglobulin heavy chain variable region	Homo sapiens	44-48
20829376-0	2010	Sialic acid-IVIg targeting CD22.	N-Acetylneuraminic Acid	0-11	CD22 molecule	Homo sapiens	27-31
20639193-6	2010	Specifically, we report the first direct evidence of expression and activity of CMP-NeuAc:GM3 sialyltransferase (Sial-T2) at the cell surface of epithelial and melanoma cells, with membrane-integrated ecto-Sial-T2 being able to sialylate endogenously synthesized GM3 ganglioside as well as exogenously incorporated substrate.	N-Acetylneuraminic Acid	84-89	tripartite motif containing 33	Homo sapiens	201-205
20538598-3	2010	Anti-influenza drugs mimic the natural sialic acid substrate of the virus neuraminidase enzyme but utilize the much tighter binding of the drugs for efficacy.	N-Acetylneuraminic Acid	39-50	neuraminidase 1	Homo sapiens	74-87
20695427-5	2010	Analysis of the crystal structures of D197 and E197 NAs with and without inhibitors showed that the D197E mutation compromised the interaction of neighboring R150 with the N-acetyl group, common to the substrate sialic acid and all NA inhibitors.	N-Acetylneuraminic Acid	212-223	neuraminidase 1	Homo sapiens	52-54
20516366-3	2010	Furthermore, we show by confocal microscopy that SA-positive IgG, but not SA-negative IgG bind to CD22.	N-Acetylneuraminic Acid	49-51	CD22 molecule	Homo sapiens	98-102
20644153-1	2010	BACKGROUND: Hereditary inclusion-body myopathy or distal myopathy with rimmed vacuoles (h-IBM/DMRV) is due to mutations of the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene, which codes for an enzyme of the sialic acid biosynthetic pathway.	N-Acetylneuraminic Acid	235-246	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	191-194
20663853-2	2010	METHODS: The level of SA in apolipoprotein B (apoB)-containing lipoproteins was determined by using enzymatic assay followed by the precipitation step in 126 alcohol-dependent men.	N-Acetylneuraminic Acid	22-24	apolipoprotein B	Homo sapiens	28-44
20663853-2	2010	METHODS: The level of SA in apolipoprotein B (apoB)-containing lipoproteins was determined by using enzymatic assay followed by the precipitation step in 126 alcohol-dependent men.	N-Acetylneuraminic Acid	22-24	apolipoprotein B	Homo sapiens	46-50
20663853-3	2010	RESULTS: Increased level and content of SA in apoB-containing lipoproteins was found not only in the hyperlipidemic alcoholic subjects but also in normolipidemic subjects.	N-Acetylneuraminic Acid	40-42	apolipoprotein B	Homo sapiens	46-50
20663853-5	2010	The increase of SA level in apoB-containing lipoproteins in type IIb hyperlipidemia is accompanied by an increase of serum apoB concentration.	N-Acetylneuraminic Acid	16-18	apolipoprotein B	Homo sapiens	28-32
20663853-5	2010	The increase of SA level in apoB-containing lipoproteins in type IIb hyperlipidemia is accompanied by an increase of serum apoB concentration.	N-Acetylneuraminic Acid	16-18	apolipoprotein B	Homo sapiens	123-127
20663853-6	2010	Increased level and content of SA in apoB-containing lipoproteins did not correlate with any markers of alcohol abuse and lipid status.	N-Acetylneuraminic Acid	31-33	apolipoprotein B	Homo sapiens	37-41
20663853-7	2010	CONCLUSIONS: There are changes in the structure of atherogenic lipoproteins in alcoholics, which consist of increasing SA concentration in apoB-containing lipoproteins.	N-Acetylneuraminic Acid	119-121	apolipoprotein B	Homo sapiens	139-143
20491786-2	2010	We have demonstrated previously that sialic acid residues of CD44 negatively regulates its receptor function and CD44 plays an important role in the accumulation of T helper type 2 (Th2) cells in the airway of a murine model of acute asthma.	N-Acetylneuraminic Acid	37-48	CD44 antigen	Mus musculus	61-65
20726802-6	2010	Furthermore, the analysis of F3, the more abundant PSA subform, showed a higher proportion of alpha 2-3 sialic acid and a decrease in core fucosylated glycans in the PCa sample.	N-Acetylneuraminic Acid	104-115	kallikrein related peptidase 3	Homo sapiens	51-54
20656882-3	2010	Here we show the ST6Gal I transfers NeuAc from the donor CMP-NeuAc to the terminal Gal of PA-type 2H, which formed the ST2H antigen, but the others could not synthesize it.	N-Acetylneuraminic Acid	36-41	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	17-25
20656882-3	2010	Here we show the ST6Gal I transfers NeuAc from the donor CMP-NeuAc to the terminal Gal of PA-type 2H, which formed the ST2H antigen, but the others could not synthesize it.	N-Acetylneuraminic Acid	61-66	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	17-25
20734133-5	2010	A recent study reported extensive diversity in the structure and composition of alpha2-6 glycans (which goes beyond the sialic acid linkage) in human upper respiratory epithelia and identified different glycan structural topologies.	N-Acetylneuraminic Acid	120-131	immunoglobulin binding protein 1	Homo sapiens	80-88
20668298-1	2010	During the evolution of humans, an inactivating deletion was introduced in the CMAH (cytidine monophosphate-sialic acid hydroxylase) gene, which eliminated biosynthesis of the common mammalian sialic acid N-glycolylneuraminic acid from all human cells.	N-Acetylneuraminic Acid	108-119	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	79-83
20359700-4	2010	One of these neurite outgrowth inhibitors is the myelin-associated glycoprotein (MAG), which is a member of the Siglec family (sialic acid-binding immunoglobulin-like lectin).	N-Acetylneuraminic Acid	127-138	myelin associated glycoprotein	Homo sapiens	49-79
20359700-4	2010	One of these neurite outgrowth inhibitors is the myelin-associated glycoprotein (MAG), which is a member of the Siglec family (sialic acid-binding immunoglobulin-like lectin).	N-Acetylneuraminic Acid	127-138	myelin associated glycoprotein	Homo sapiens	81-84
20400674-0	2010	Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain.	N-Acetylneuraminic Acid	63-74	ficolin 1	Homo sapiens	13-22
21218055-1	2010	Synthetic sialic acid analogues with multiple modifications at different positions(C-1/C-2/C-4/C-8/C-9) are investigated by molecular mechanics and molecular dynamics to determine their conformational preferences and structural stability to interact with their natural receptors.	N-Acetylneuraminic Acid	10-21	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	83-86
21218055-1	2010	Synthetic sialic acid analogues with multiple modifications at different positions(C-1/C-2/C-4/C-8/C-9) are investigated by molecular mechanics and molecular dynamics to determine their conformational preferences and structural stability to interact with their natural receptors.	N-Acetylneuraminic Acid	10-21	complement C2	Homo sapiens	87-90
21218055-1	2010	Synthetic sialic acid analogues with multiple modifications at different positions(C-1/C-2/C-4/C-8/C-9) are investigated by molecular mechanics and molecular dynamics to determine their conformational preferences and structural stability to interact with their natural receptors.	N-Acetylneuraminic Acid	10-21	complement C4A (Rodgers blood group)	Homo sapiens	91-94
20400674-8	2010	Ficolin-1 is tethered to the cell surface of these cells through its fibrinogen-like domain, and the ligand involved in the binding of Ficolin-1 is shown to be sialic acid.	N-Acetylneuraminic Acid	160-171	ficolin 1	Homo sapiens	135-144
20455239-3	2010	Selective oxidation of the sialic acid residues on the glycan chains of transferrin was followed by introduction of a terminal alkyne functionality through an oxime linkage.	N-Acetylneuraminic Acid	27-38	transferrin	Homo sapiens	72-83
20379804-3	2010	The terminal sialic acid in the N-linked glycans of FVIII is required for maximal circulatory half life.	N-Acetylneuraminic Acid	13-24	coagulation factor VIII	Homo sapiens	52-57
20585558-8	2010	We show that soluble CR1 (sCR1) as well as polyclonal and monoclonal antibodies against CR1 inhibit sialic acid-independent invasion in a variety of laboratory strains and wild isolates, and that merozoites interact directly with CR1 on the erythrocyte surface and with sCR1-coated microspheres.	N-Acetylneuraminic Acid	100-111	complement receptor 2	Mus musculus	21-24
20585558-10	2010	Finally, both sialic acid-independent and dependent strains invade CR1 transgenic mouse erythrocytes preferentially over wild-type erythrocytes but invasion by the latter is more sensitive to neuraminidase.	N-Acetylneuraminic Acid	14-25	complement receptor 2	Mus musculus	67-70
20585558-11	2010	These results suggest that both sialic acid-dependent and independent strains interact with CR1 in the normal red cell during the invasion process.	N-Acetylneuraminic Acid	32-43	complement receptor 2	Mus musculus	92-95
20424173-1	2010	Salla disease and infantile sialic acid storage disorder are human diseases caused by loss of function of sialin, a lysosomal transporter that mediates H(+)-coupled symport of acidic sugars N-acetylneuraminic acid and glucuronic acid out of lysosomes.	N-Acetylneuraminic Acid	190-213	solute carrier family 17 member 5	Homo sapiens	106-112
20181615-2	2010	A current clinical target for B-cell lymphoma is CD22, a B-cell-specific member of the sialic acid binding Ig-like lectin (siglec) family that recognizes alpha2-6-linked sialylated glycans as ligands.	N-Acetylneuraminic Acid	87-98	CD22 molecule	Homo sapiens	49-53
20392887-0	2010	Binding to gangliosides containing N-acetylneuraminic acid is sufficient to mediate the immunomodulatory properties of the nontoxic mucosal adjuvant LT-IIb(T13I).	N-Acetylneuraminic Acid	35-58	ATPase, class II, type 9B	Mus musculus	152-155
20307522-7	2010	In non-surviving cancer patients the concentration of IGFBP-3 was significantly reduced and these molecules contained a greater amount of biantennary complex type N-glycans having more mannose, fucose, bisecting GlcNAc and terminal sialic acid residues.	N-Acetylneuraminic Acid	232-243	insulin like growth factor binding protein 3	Homo sapiens	54-61
20178128-9	2010	RESULTS: Compared with the pool of serum IgG1, ACPA IgG1 lacked terminal sialic acid residues.	N-Acetylneuraminic Acid	73-84	proteinase 3	Homo sapiens	47-51
20178128-10	2010	In SF, ACPA were highly agalactosylated and lacked sialic acid residues, a feature that was not detected for total SF IgG1.	N-Acetylneuraminic Acid	51-62	proteinase 3	Homo sapiens	7-11
20409718-1	2010	Siglec-2 is a mammalian sialic acid binding protein expressed on B-cell surfaces and is involved in the modulation of B-cell mediated immune response.	N-Acetylneuraminic Acid	24-35	CD22 molecule	Homo sapiens	0-8
20409718-3	2010	Saturation transfer difference NMR experiments indicated that the C7-C9 side-chain and the acetamide moiety of the central sialic acid residue were located in the binding face of human Siglec-2.	N-Acetylneuraminic Acid	123-134	CD22 molecule	Homo sapiens	185-193
20548120-2	2010	Sialic acid biosynthesis occurs in the cytosol, where UDP-N-acetylglucosamine (GlcNAc) is sequentially converted to N-acetylmannosamine (ManNAc) 6-phosphate by UDP-GlcNAc-2-epimerase/ManNAc kinase enzymes, both of which are encoded by the GNE gene.	N-Acetylneuraminic Acid	0-11	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	239-242
20548120-3	2010	Since the only existing mouse model of DMRV/hIBM (Gne(-/-)hGNED176VTg) exhibited decreased sialic acid levels in most organs, DMRV/hIBM is thought to be secondary to the metabolic defect in sialic acid production.	N-Acetylneuraminic Acid	91-102	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	50-53
20548120-9	2010	Thus our results show that the oral therapy with NeuAc and ManNAc or their derivatives is safe and effective in preventing myopathic symptoms in Gne(-/-)hGNED176VTg mice, and could be considered as a guide for further therapeutic trials.	N-Acetylneuraminic Acid	49-54	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	145-148
20392887-2	2010	In contrast to LT-IIb, which binds strongly to ganglioside receptors decorated with either N-acetylneuraminic acid (NeuAc) or N-glycolylneuraminic acid (NeuGc), LT-IIb(T13I) binds NeuAc gangliosides much less well.	N-Acetylneuraminic Acid	91-114	ATPase, class II, type 9B	Mus musculus	18-21
20392887-2	2010	In contrast to LT-IIb, which binds strongly to ganglioside receptors decorated with either N-acetylneuraminic acid (NeuAc) or N-glycolylneuraminic acid (NeuGc), LT-IIb(T13I) binds NeuAc gangliosides much less well.	N-Acetylneuraminic Acid	116-121	ATPase, class II, type 9B	Mus musculus	18-21
20231688-7	2010	Thus, humans manifest a generalized lymphocyte over-reactivity relative to chimpanzees, a finding that is correlated with decreased levels of inhibitory sialic acid-recognizing Ig-superfamily lectins (Siglecs; particularly Siglec-5) on human T and B cells.	N-Acetylneuraminic Acid	153-164	sialic acid-binding Ig-like lectin 5	Pan troglodytes	223-231
20197272-2	2010	The only known biosynthetic pathway of Neu5Gc is the hydroxylation of cytidine-5"-monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac), catalyzed by CMP-Neu5Ac hydroxylase (CMAH).	N-Acetylneuraminic Acid	125-131	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	147-169
20197272-2	2010	The only known biosynthetic pathway of Neu5Gc is the hydroxylation of cytidine-5"-monophosphate-N-acetylneuraminic acid (CMP-Neu5Ac), catalyzed by CMP-Neu5Ac hydroxylase (CMAH).	N-Acetylneuraminic Acid	125-131	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	171-175
20331970-5	2010	An increased expression and secretion of thioredoxin is achieved by the application of the novel sialic acid precursor N-propionylmannosamine (ManNProp).	N-Acetylneuraminic Acid	97-108	thioredoxin 1	Rattus norvegicus	41-52
20486931-3	2010	We previously reported the synthesis of chimeric alpha/delta-peptides from glutamic acids (Glu) and the sialic acid derivative Neu2en.	N-Acetylneuraminic Acid	104-115	neuraminidase 2	Homo sapiens	127-131
20422448-2	2010	In this study, flow cytometry and Western blot analyses of pig red blood cells showed that alpha-Gal epitopes on pig red cells developed concomitantly after treatment with neuraminidase, suggesting that the terminal N-acetyllactosaminide glycans were capped with SA-alpha-Gal epitopes.	N-Acetylneuraminic Acid	263-265	GLA	Sus scrofa	91-100
20385334-1	2010	Factor H is a 155kDa sialic acid containing glycoprotein that plays an integral role in the regulation of the complement-mediated immune system that is involved in microbial defense, immune complex processing, and programmed cell death.	N-Acetylneuraminic Acid	21-32	complement factor H	Homo sapiens	0-8
20445087-4	2010	Specific events include Alu-mediated inactivation of the CMAH gene, resulting in loss of synthesis of the Sia N-glycolylneuraminic acid (Neu5Gc) and increase in expression of the precursor N-acetylneuraminic acid (Neu5Ac); increased expression of alpha2-6-linked Sias (likely because of changed expression of ST6GALI); and multiple changes in SIGLEC genes encoding Sia-recognizing Ig-like lectins (Siglecs).	N-Acetylneuraminic Acid	189-212	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	57-61
20445087-4	2010	Specific events include Alu-mediated inactivation of the CMAH gene, resulting in loss of synthesis of the Sia N-glycolylneuraminic acid (Neu5Gc) and increase in expression of the precursor N-acetylneuraminic acid (Neu5Ac); increased expression of alpha2-6-linked Sias (likely because of changed expression of ST6GALI); and multiple changes in SIGLEC genes encoding Sia-recognizing Ig-like lectins (Siglecs).	N-Acetylneuraminic Acid	214-220	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	57-61
20335532-2	2010	CD22, one of the sialic acid-binding immunoglobulin-like lectins, is a B cell-specific molecule that negatively regulates BCR signaling.	N-Acetylneuraminic Acid	17-28	CD22 antigen	Mus musculus	0-4
20106975-4	2010	Binding of the monoclonal antibody S7, which recognizes sialic acid-containing epitopes on the 115-kDa isoform of CD43, was augmented on CD8(+) T cells from ST3Gal-I-deficient infected mice, indicating that CD43 is one sialic acid acceptor for trans-sialidase activity on the CD8(+) T cell surface.	N-Acetylneuraminic Acid	56-67	sialophorin	Mus musculus	114-118
20106975-4	2010	Binding of the monoclonal antibody S7, which recognizes sialic acid-containing epitopes on the 115-kDa isoform of CD43, was augmented on CD8(+) T cells from ST3Gal-I-deficient infected mice, indicating that CD43 is one sialic acid acceptor for trans-sialidase activity on the CD8(+) T cell surface.	N-Acetylneuraminic Acid	219-230	sialophorin	Mus musculus	114-118
20303677-2	2010	These analogues have been developed from the structure of sialic acid, the neuraminidase (NA) substrate.	N-Acetylneuraminic Acid	58-69	neuraminidase 1	Homo sapiens	75-88
20180850-7	2010	Neuraminidase treatment of colonic Caco-2 cells removed 27-58% of surface sialic acid.	N-Acetylneuraminic Acid	74-85	neuraminidase 1	Homo sapiens	0-13
20383336-2	2010	It is caused by a single missense mutation of each allele of the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene, a bifunctional enzyme catalyzing the first two steps of sialic acid synthesis in mammals.	N-Acetylneuraminic Acid	196-207	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	129-132
19965639-0	2010	Expression of terminal alpha2-6-linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13.	N-Acetylneuraminic Acid	39-50	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	113-121
19965639-3	2010	In this study, the role of terminal sialic acid residues on VWF glycans in mediating proteolysis by ADAMTS13 was investigated.	N-Acetylneuraminic Acid	36-47	von Willebrand factor	Homo sapiens	60-63
19965639-3	2010	In this study, the role of terminal sialic acid residues on VWF glycans in mediating proteolysis by ADAMTS13 was investigated.	N-Acetylneuraminic Acid	36-47	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	100-108
19965639-5	2010	Total sialic acid expression on VWF was 167nmol/mg, of which the majority (80.1%) was present on N-linked glycan chains.	N-Acetylneuraminic Acid	6-17	von Willebrand factor	Homo sapiens	32-35
19965639-11	2010	These novel data show that sialic acid protects VWF against proteolysis by serine and cysteine proteases but specifically enhances susceptibility to ADAMTS13 proteolysis.	N-Acetylneuraminic Acid	27-38	von Willebrand factor	Homo sapiens	48-51
19965639-11	2010	These novel data show that sialic acid protects VWF against proteolysis by serine and cysteine proteases but specifically enhances susceptibility to ADAMTS13 proteolysis.	N-Acetylneuraminic Acid	27-38	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	149-157
20119645-2	2010	PolySia, a homopolymer of alpha-2,8-linked sialic acid, is involved in post-translational modification of the neural cell adhesion molecule (NCAM).	N-Acetylneuraminic Acid	43-54	neural cell adhesion molecule 1	Homo sapiens	110-139
20119645-2	2010	PolySia, a homopolymer of alpha-2,8-linked sialic acid, is involved in post-translational modification of the neural cell adhesion molecule (NCAM).	N-Acetylneuraminic Acid	43-54	neural cell adhesion molecule 1	Homo sapiens	141-145
20303677-2	2010	These analogues have been developed from the structure of sialic acid, the neuraminidase (NA) substrate.	N-Acetylneuraminic Acid	58-69	neuraminidase 1	Homo sapiens	90-92
19285339-6	2010	The specificity of sialic acid binding membrane-anchored lectins, siglecs-1, -5, -7, -8 and -9 was determined using this methodology.	N-Acetylneuraminic Acid	19-30	sialic acid binding Ig like lectin 1	Homo sapiens	66-94
19653112-5	2010	Lectin blot analyses revealed that significant amounts of the oligosaccharide chains of hEpo/Fc produced in the serum and eggs of GM chickens terminated with galactose, and that the oligosaccharide chains of the serum- and yolk-derived hEpo/Fc incorporated sialic acid residues.	N-Acetylneuraminic Acid	257-268	erythropoietin	Homo sapiens	88-92
19786330-0	2010	Sialic acid-dependent binding and transcytosis of serotype D botulinum neurotoxin and toxin complex in rat intestinal epithelial cells.	N-Acetylneuraminic Acid	0-11	neurotoxin	Clostridium botulinum	71-81
20175955-5	2010	Mutation analysis revealed compound heterozygous mutations in the GNE gene, encoding the key enzyme in sialic acid synthesis UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase: a missense mutation (c.2086G &gt; A; p.V696M) previously described in HIBM patients of Indian origin, and a novel frame shift mutation (c.1295delA; p.K432RfsX17) leading to a premature stopcodon.	N-Acetylneuraminic Acid	103-114	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	66-69
20067560-4	2010	Total sialic acid and galactose expression are reduced twofold on platelet VWF, and ABO blood group carbohydrate determinants are not present on the N-linked glycans of platelet VWF.	N-Acetylneuraminic Acid	6-17	von Willebrand factor	Homo sapiens	75-78
20175955-5	2010	Mutation analysis revealed compound heterozygous mutations in the GNE gene, encoding the key enzyme in sialic acid synthesis UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase: a missense mutation (c.2086G &gt; A; p.V696M) previously described in HIBM patients of Indian origin, and a novel frame shift mutation (c.1295delA; p.K432RfsX17) leading to a premature stopcodon.	N-Acetylneuraminic Acid	103-114	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	125-187
20032046-1	2010	Siglec-7, a sialic acid binding immunoglobulin-like lectin, predominantly transduces inhibitory signals through cytosolic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).	N-Acetylneuraminic Acid	12-23	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
19917666-1	2010	The bifunctional enzyme UDP-GlcNAc 2-epimerase/ ManNAc kinase (GNE/MNK), encoded by the GNE gene, catalyzes the first two committed, rate-limiting steps in the biosynthesis of N-acetylneuraminic acid (sialic acid).	N-Acetylneuraminic Acid	176-199	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	63-66
19917666-1	2010	The bifunctional enzyme UDP-GlcNAc 2-epimerase/ ManNAc kinase (GNE/MNK), encoded by the GNE gene, catalyzes the first two committed, rate-limiting steps in the biosynthesis of N-acetylneuraminic acid (sialic acid).	N-Acetylneuraminic Acid	176-199	ATPase copper transporting alpha	Homo sapiens	67-70
20032467-10	2010	These analyses reveal novel ficolin ligands such as sulfated N-acetyllactosamine (L-ficolin) and gangliosides (M-ficolin) and provide precise insights into the sialic acid binding specificity of M-ficolin, emphasizing the essential role of Tyr(271) in this respect.	N-Acetylneuraminic Acid	160-171	ficolin 1	Homo sapiens	195-204
19917666-1	2010	The bifunctional enzyme UDP-GlcNAc 2-epimerase/ ManNAc kinase (GNE/MNK), encoded by the GNE gene, catalyzes the first two committed, rate-limiting steps in the biosynthesis of N-acetylneuraminic acid (sialic acid).	N-Acetylneuraminic Acid	176-199	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	88-91
19917666-1	2010	The bifunctional enzyme UDP-GlcNAc 2-epimerase/ ManNAc kinase (GNE/MNK), encoded by the GNE gene, catalyzes the first two committed, rate-limiting steps in the biosynthesis of N-acetylneuraminic acid (sialic acid).	N-Acetylneuraminic Acid	201-212	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	63-66
19917666-1	2010	The bifunctional enzyme UDP-GlcNAc 2-epimerase/ ManNAc kinase (GNE/MNK), encoded by the GNE gene, catalyzes the first two committed, rate-limiting steps in the biosynthesis of N-acetylneuraminic acid (sialic acid).	N-Acetylneuraminic Acid	201-212	ATPase copper transporting alpha	Homo sapiens	67-70
19917666-1	2010	The bifunctional enzyme UDP-GlcNAc 2-epimerase/ ManNAc kinase (GNE/MNK), encoded by the GNE gene, catalyzes the first two committed, rate-limiting steps in the biosynthesis of N-acetylneuraminic acid (sialic acid).	N-Acetylneuraminic Acid	201-212	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	88-91
19917666-2	2010	GNE/MNK is feedback inhibited by binding of the downstream product, CMP-sialic acid in its allosteric site.	N-Acetylneuraminic Acid	72-83	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
19917666-2	2010	GNE/MNK is feedback inhibited by binding of the downstream product, CMP-sialic acid in its allosteric site.	N-Acetylneuraminic Acid	72-83	ATPase copper transporting alpha	Homo sapiens	4-7
21179605-3	2010	This disease is known to be caused by mutations in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase gene, which encodes the essential enzyme in sialic acid biosynthesis, leading to a reduction of sialic acid levels in the serum and skeletal muscles of affected patients.	N-Acetylneuraminic Acid	162-173	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	55-117
21179605-3	2010	This disease is known to be caused by mutations in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase gene, which encodes the essential enzyme in sialic acid biosynthesis, leading to a reduction of sialic acid levels in the serum and skeletal muscles of affected patients.	N-Acetylneuraminic Acid	214-225	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	55-117
20032467-0	2010	Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin.	N-Acetylneuraminic Acid	90-101	ficolin 1	Homo sapiens	125-134
20032467-6	2010	M-ficolin bound preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.	N-Acetylneuraminic Acid	60-71	ficolin 1	Homo sapiens	0-9
20032467-7	2010	To further investigate the structural basis of sialic acid recognition by M-ficolin, point mutants were produced in which three residues of the fibrinogen domain were replaced by their counterparts in L-ficolin.	N-Acetylneuraminic Acid	47-58	ficolin 1	Homo sapiens	74-83
19755471-4	2010	Sialic acid is a negatively charged carbohydrate extensively present on both alpha-DG and podocalyxin, which is also expressed on podocytes.	N-Acetylneuraminic Acid	0-11	podocalyxin like	Homo sapiens	90-101
20095613-1	2010	The injured adult mammalian central nervous system is an inhibitory environment for axon regeneration due to specific inhibitors, among them the myelin-associated glycoprotein (MAG), a member of the Siglec family (sialic-acid binding immunoglobulin-like lectin).	N-Acetylneuraminic Acid	214-225	myelin associated glycoprotein	Homo sapiens	145-175
20095613-1	2010	The injured adult mammalian central nervous system is an inhibitory environment for axon regeneration due to specific inhibitors, among them the myelin-associated glycoprotein (MAG), a member of the Siglec family (sialic-acid binding immunoglobulin-like lectin).	N-Acetylneuraminic Acid	214-225	myelin associated glycoprotein	Homo sapiens	177-180
20092260-6	2010	Nano-LC/MS of O-linked oligosaccharides on MUC2 from a human colon biopsy also illustrated that the ionization of oligosaccharides with multiple sialic acid groups was increased compared to those with only one sialic acid residue.	N-Acetylneuraminic Acid	145-156	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	43-47
20092260-6	2010	Nano-LC/MS of O-linked oligosaccharides on MUC2 from a human colon biopsy also illustrated that the ionization of oligosaccharides with multiple sialic acid groups was increased compared to those with only one sialic acid residue.	N-Acetylneuraminic Acid	210-221	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	43-47
19669698-9	2010	CONCLUSIONS: Our data show that AGP can stimulate a second ROS response in fMLP preactivated neutrophils and that terminal sialic acid residues on AGP play a crucial role in this regard.	N-Acetylneuraminic Acid	123-134	formyl peptide receptor 1	Homo sapiens	75-79
20657722-9	2010	In addition, a novel sialic acid-modified linkage hexasaccharide was found conjugated to bikunin, the most abundant serum proteoglycan.	N-Acetylneuraminic Acid	21-32	alpha-1-microglobulin/bikunin precursor	Homo sapiens	89-96
19892032-5	2010	HTLV-1 virions are believed to be weakly infectious under cell culture conditions; however, we found that the treatment of HTLV-1 virions with microbial neuraminidase, an enzyme catalyzing the removal of sialic acid residues from various glycoconjugates, enhanced the number of proviral DNAs in infected cells in a dose-dependent manner.	N-Acetylneuraminic Acid	204-215	neuraminidase 1	Homo sapiens	153-166
20084110-0	2010	The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	125-136	sialic acid binding Ig like lectin 1	Homo sapiens	98-110
20101035-0	2010	Elevated CSF N-acetylaspartylglutamate in patients with free sialic acid storage diseases.	N-Acetylneuraminic Acid	61-72	colony stimulating factor 2	Homo sapiens	9-12
20101035-3	2010	RESULTS: We found a significant increase of free sialic acid in CSF or urine in 6 of 41 patients presenting with hypomyelination of unknown etiology.	N-Acetylneuraminic Acid	49-60	colony stimulating factor 2	Homo sapiens	64-67
20101035-6	2010	CONCLUSION: In patients with undiagnosed leukodystrophies, increased free sialic acid in CSF or urine is a marker for free sialic acid storage disorder and facilitates the identification of the underlying genetic defect.	N-Acetylneuraminic Acid	74-85	colony stimulating factor 2	Homo sapiens	89-92
19920154-6	2010	Furthermore, regulation of galectin-1 signaling by alpha2,6-sialylation of N-glycans is not solely dependent on CD45 phosphatase activity and can be modulated by the relative expression of enzymes that attach sialic acid in an alpha2,6- or alpha2,3-linkage.	N-Acetylneuraminic Acid	209-220	galectin 1	Homo sapiens	27-37
20084110-6	2010	The soluble sialoadhesin could bind PRRSV in a sialic acid-dependent manner and could neutralize PRRSV infection of macrophages, thereby confirming the role of sialoadhesin as an essential PRRSV receptor on macrophages.	N-Acetylneuraminic Acid	47-58	sialic acid binding Ig like lectin 1	Homo sapiens	12-24
20084110-8	2010	The interaction was found to be dependent on the sialic acid binding capacity of sialoadhesin and on the presence of sialic acids on GP(5).	N-Acetylneuraminic Acid	49-60	sialic acid binding Ig like lectin 1	Homo sapiens	81-93
19415310-0	2010	Sialidosis type I carrying V217M/G243R mutations in lysosomal sialidase: an autopsy study demonstrating terminal sialic acid in lysosomal lamellar inclusions and cerebellar dysplasia.	N-Acetylneuraminic Acid	113-124	neuraminidase 1	Homo sapiens	52-71
19797319-3	2010	The key enzyme of sialic acid biosynthesis is the bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE), which catalyzes the first two steps of sialic acid biosynthesis in the cytosol.	N-Acetylneuraminic Acid	18-29	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	127-130
21048299-2	2010	Through in vitro reconstitution, we found that sialin, a lysosomal sialic acid exporter, is responsible for the vesicular storage of aspartate in hippocampal neurons and pinealocytes.	N-Acetylneuraminic Acid	67-78	solute carrier family 17 member 5	Homo sapiens	47-53
19936918-10	2010	Treatment with sialidase significantly decreased the inhibitory properties of Muc1, demonstrating the importance of sialic acid in adhesion inhibition.	N-Acetylneuraminic Acid	116-127	mucin 1, cell surface associated	Homo sapiens	78-82
20823580-4	2010	Negatively charged sialic acid residues are known to be critical for in vivo bioactivity of recombinant human erythropoietin (rhEPO).	N-Acetylneuraminic Acid	19-30	erythropoietin	Homo sapiens	110-124
19797319-3	2010	The key enzyme of sialic acid biosynthesis is the bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE), which catalyzes the first two steps of sialic acid biosynthesis in the cytosol.	N-Acetylneuraminic Acid	172-183	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	127-130
19890021-8	2010	The decline in the variant LH during GnRH receptor blockade was associated with a decrease in sulfonated and an increase in sialic acid residues similar to that for in wild-type LH.	N-Acetylneuraminic Acid	124-135	gonadotropin releasing hormone receptor	Homo sapiens	37-50
19670261-3	2010	PSA sialic acid content is altered in tumor situation and modifies PSA"s isoelectric point (pI).	N-Acetylneuraminic Acid	4-15	kallikrein related peptidase 3	Homo sapiens	0-3
19855092-0	2010	Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation.	N-Acetylneuraminic Acid	0-11	adiponectin, C1Q and collagen domain containing	Mus musculus	28-39
19855092-11	2010	These data suggest an important role for sialic acid content in the regulation of circulating adiponectin levels and highlight the importance of understanding mechanisms regulating adiponectin sialylation/desialylation.	N-Acetylneuraminic Acid	41-52	adiponectin, C1Q and collagen domain containing	Mus musculus	94-105
19670261-3	2010	PSA sialic acid content is altered in tumor situation and modifies PSA"s isoelectric point (pI).	N-Acetylneuraminic Acid	4-15	kallikrein related peptidase 3	Homo sapiens	67-70
20120346-10	2010	DMRV is caused by mutations in GNE gene that encode a rate-limiting enzyme in the sialic acid biosynthetic pathway.	N-Acetylneuraminic Acid	82-93	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	31-34
20149189-10	2010	The EC from the GalT-KO pig signals for EEL &amp; GSI-B4 disappeared and those for Bauhinia purpurea alba (BPL), HPA, SBA, &amp; GSI-A4 were greatly diminished as well, while it up-regulated signals for Sambucus Nigra (SNA), Sambucus sieboldiana (SSA), &amp; TJA-I, bind alpha2-6 sialic acid, compared to the wild-type pig EC.	N-Acetylneuraminic Acid	280-291	galactose-1-phosphate uridylyltransferase	Sus scrofa	16-20
19947630-1	2009	In order to understand the biological importance of naturally occurring sialic acid variations on disialyl structures in nature, we developed an efficient two-step multienzyme approach for the synthesis of a series of GD3 ganglioside oligosaccharides and other disialyl glycans containing a terminal Siaalpha2-8Sia component with different natural and non-natural sialic acids.	N-Acetylneuraminic Acid	72-83	GRDX	Homo sapiens	218-221
19578160-6	2009	We also examined the modulatory effect of sialic acid residues on the binding of gp96 to APCs and its subsequent activation.	N-Acetylneuraminic Acid	42-53	amyloid P component, serum	Rattus norvegicus	89-93
20007460-1	2009	Salla disease and infantile sialic acid storage disease are autosomal recessive lysosomal storage disorders caused by mutations in the gene encoding sialin, a membrane protein that transports free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation.	N-Acetylneuraminic Acid	28-39	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	149-155
20007460-1	2009	Salla disease and infantile sialic acid storage disease are autosomal recessive lysosomal storage disorders caused by mutations in the gene encoding sialin, a membrane protein that transports free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation.	N-Acetylneuraminic Acid	197-208	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	149-155
19899793-5	2009	We demonstrated that the minimal antigenic structure, an essential epitope, recognized by anti-KL-6 MAb is a heptapeptide sequence Pro-Asp-Thr-Arg-Pro-Ala-Pro (PDTRPAP), in which the Thr residue is modified by Neu5Ac alpha2,3Gal beta1,3GalNAc alpha (2,3-sialyl T antigen, core 1-type O-glycan).	N-Acetylneuraminic Acid	210-216	mucin 1, cell surface associated	Homo sapiens	95-99
19845399-1	2009	The alpha-2,6-sialyltransferase (ST6Gal-I) is a key enzyme that regulates the distribution of sialic acid-containing molecules on mammalian cell surfaces.	N-Acetylneuraminic Acid	94-105	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	33-41
19933851-2	2009	CD33-related sialic acid binding Ig-like lectin receptors (Siglecs) have been implicated in the control of leukocyte responses.	N-Acetylneuraminic Acid	13-24	CD33 antigen	Mus musculus	0-4
19696237-9	2009	The expression of the nitrergic marker nNOS was increased upon sialic acid feeding in aged rats.	N-Acetylneuraminic Acid	63-74	nitric oxide synthase 1	Rattus norvegicus	39-43
19578160-7	2009	Our results supported the contention that significant differences in the sialic acid content exist between Dunning G, MAT-LyLu, and normal rat prostate gp96, which affected its binding and biochemical activity to APCs.	N-Acetylneuraminic Acid	73-84	amyloid P component, serum	Rattus norvegicus	213-217
20030229-1	2009	Distal myopathy with rimmed vacuoles (DMRV), also called hereditary inclusion body myopathy, is an autosomal recessive disorder caused by homozygous or compound heterozygous missense mutations in GNE which encodes a protein with two enzymatic activities in sialic acid biosynthesis: UDP-GlcNAc 2-epimerase and ManNAc kinase.	N-Acetylneuraminic Acid	257-268	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	196-199
19696237-11	2009	However, the colonic expression of specific nervous system markers nNOS and Uchl1 and the key enzyme for sialic acid synthesis GNE were differentially affected in young and aged rats by sialic acid feeding indicating that regulatory mechanisms change with age.	N-Acetylneuraminic Acid	105-116	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	127-130
19696237-11	2009	However, the colonic expression of specific nervous system markers nNOS and Uchl1 and the key enzyme for sialic acid synthesis GNE were differentially affected in young and aged rats by sialic acid feeding indicating that regulatory mechanisms change with age.	N-Acetylneuraminic Acid	186-197	nitric oxide synthase 1	Rattus norvegicus	67-71
19696237-11	2009	However, the colonic expression of specific nervous system markers nNOS and Uchl1 and the key enzyme for sialic acid synthesis GNE were differentially affected in young and aged rats by sialic acid feeding indicating that regulatory mechanisms change with age.	N-Acetylneuraminic Acid	186-197	ubiquitin C-terminal hydrolase L1	Rattus norvegicus	76-81
19696237-11	2009	However, the colonic expression of specific nervous system markers nNOS and Uchl1 and the key enzyme for sialic acid synthesis GNE were differentially affected in young and aged rats by sialic acid feeding indicating that regulatory mechanisms change with age.	N-Acetylneuraminic Acid	186-197	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	127-130
19704115-0	2009	ABO blood group glycans modulate sialic acid recognition on erythrocytes.	N-Acetylneuraminic Acid	33-44	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	0-15
19704115-4	2009	We show in this study that ABH antigens found on human erythrocytes modulate the specific interactions of 3 sialic acid-recognizing proteins (human Siglec-2, 1918SC influenza hemagglutinin, and Sambucus nigra agglutinin) with sialylated glycans on the same cell surface.	N-Acetylneuraminic Acid	108-119	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	27-30
19704115-4	2009	We show in this study that ABH antigens found on human erythrocytes modulate the specific interactions of 3 sialic acid-recognizing proteins (human Siglec-2, 1918SC influenza hemagglutinin, and Sambucus nigra agglutinin) with sialylated glycans on the same cell surface.	N-Acetylneuraminic Acid	108-119	CD22 molecule	Homo sapiens	148-156
19704115-5	2009	Using specific glycosidases that convert A and B glycans to the underlying H(O) structure, we show ABH antigens stabilize sialylated glycan clusters on erythrocyte membranes uniquely for each blood type, generating differential interactions of the 3 sialic acid-binding proteins with erythrocytes from each blood type.	N-Acetylneuraminic Acid	250-261	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	99-102
19704115-6	2009	We further show that by stabilizing such structures ABH antigens can also modulate sialic acid-mediated interaction of pathogens such as Plasmodium falciparum malarial parasite.	N-Acetylneuraminic Acid	83-94	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	52-55
19841673-1	2009	BACKGROUND: UDP-GlcNAc 2-epimerase/ManNAc 6-kinase, GNE, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis.	N-Acetylneuraminic Acid	108-119	renin binding protein	Homo sapiens	16-34
19841673-1	2009	BACKGROUND: UDP-GlcNAc 2-epimerase/ManNAc 6-kinase, GNE, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis.	N-Acetylneuraminic Acid	108-119	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	35-55
19464343-2	2009	Galbeta1,3GlcNAcalpha2,3-sialyltransferase (ST3Gal III) and Galbeta1,4GlcNAcalpha2,6-sialyltransferase (ST6Gal I) incorporate sialic acid residues into FSH oligosaccharides.	N-Acetylneuraminic Acid	126-137	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Rattus norvegicus	104-112
19783675-1	2009	Siglec-F is a sialic acid-binding Ig superfamily receptor that is highly expressed on eosinophils.	N-Acetylneuraminic Acid	14-25	sialic acid binding Ig-like lectin F	Mus musculus	0-8
19788761-7	2009	Furthermore, we have developed a novel high-throughput assay for the detection of sialyltransferase activity and used it to demonstrate that the bacterially expressed ST6 enzyme is active and able to transfer sialic acid onto a desialylated O-glycoprotein, bovine submaxillary mucin.	N-Acetylneuraminic Acid	209-220	CD82 molecule	Homo sapiens	167-170
19415461-5	2009	In the current study, we performed purification of CMP-N-acetylneuraminic acid:lactosylceramide alpha2,3-sialyltransferase (GM3 synthase) from Triton X-100 extract of human blood mononuclear cells by immunoaffinity chromatography on Sepharose coupled with anti-GM3 synthase antibody.	N-Acetylneuraminic Acid	55-78	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	79-122
19415461-5	2009	In the current study, we performed purification of CMP-N-acetylneuraminic acid:lactosylceramide alpha2,3-sialyltransferase (GM3 synthase) from Triton X-100 extract of human blood mononuclear cells by immunoaffinity chromatography on Sepharose coupled with anti-GM3 synthase antibody.	N-Acetylneuraminic Acid	55-78	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	124-136
19415461-5	2009	In the current study, we performed purification of CMP-N-acetylneuraminic acid:lactosylceramide alpha2,3-sialyltransferase (GM3 synthase) from Triton X-100 extract of human blood mononuclear cells by immunoaffinity chromatography on Sepharose coupled with anti-GM3 synthase antibody.	N-Acetylneuraminic Acid	55-78	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	261-273
19720531-0	2009	Potent small molecule mouse CD22-inhibitors: exploring the interaction of the residue at C-2 of sialic acid scaffold.	N-Acetylneuraminic Acid	96-107	CD22 antigen	Mus musculus	28-32
19740323-3	2009	Furthermore, DC endocytosis was reduced upon removal of the cell surface sialic acid residues by neuraminidase.	N-Acetylneuraminic Acid	73-84	neuraminidase 1	Homo sapiens	97-110
19631531-0	2009	Synthesis of sialic acid derivatives having a C=C double bond substituted at the C-5 position and their glycopolymers.	N-Acetylneuraminic Acid	13-24	complement C5	Homo sapiens	81-84
19631531-1	2009	Glycomonomers of sialic acid in which the acetamide group at C-5 was converted into two kinds of C=C double bond substituents were prepared and the fully protected glycomonomers were directly polymerized before deprotection steps.	N-Acetylneuraminic Acid	17-28	complement C5	Homo sapiens	61-64
19500664-8	2009	The removal of SA also increased O(2)(-) production as indicated by DHE fluorescent signals (86+/-17% increase) and the addition of tempol, a mimic O(2)(-) scavenger, restored both NO availability and vasodilation in both heparinase- and neuraminidase-treated vessels.	N-Acetylneuraminic Acid	15-17	neuraminidase 1	Homo sapiens	238-251
19528219-0	2009	Influenza A virus neuraminidase enhances meningococcal adhesion to epithelial cells through interaction with sialic acid-containing meningococcal capsules.	N-Acetylneuraminic Acid	109-120	neuraminidase 1	Homo sapiens	18-31
19528219-4	2009	Expression of a recombinant IAV NA in Hec-1-B human epithelial cells increased the adhesion of strains of N. meningitidis belonging to the sialic acid-containing capsular serogroups B, C, and W135 but not to the mannosamine phosphate-containing capsular serogroup A. Adhesion enhancement was not observed with an inactive NA mutant or in the presence of an NA inhibitor (zanamivir).	N-Acetylneuraminic Acid	139-150	NDC80 kinetochore complex component	Homo sapiens	38-43
19596068-5	2009	GNE/MNK catalyzes the first two committed steps in the biosynthesis of acetylneuraminic acid (Neu5Ac), an abundant and functionally important sugar.	N-Acetylneuraminic Acid	71-92	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
19596068-5	2009	GNE/MNK catalyzes the first two committed steps in the biosynthesis of acetylneuraminic acid (Neu5Ac), an abundant and functionally important sugar.	N-Acetylneuraminic Acid	71-92	ATPase copper transporting alpha	Homo sapiens	4-7
19596068-5	2009	GNE/MNK catalyzes the first two committed steps in the biosynthesis of acetylneuraminic acid (Neu5Ac), an abundant and functionally important sugar.	N-Acetylneuraminic Acid	94-100	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
19596068-5	2009	GNE/MNK catalyzes the first two committed steps in the biosynthesis of acetylneuraminic acid (Neu5Ac), an abundant and functionally important sugar.	N-Acetylneuraminic Acid	94-100	ATPase copper transporting alpha	Homo sapiens	4-7
19426133-5	2009	GNE knock-out in mice leads to embryonic lethality, emphasizing the crucial role of this key enzyme for sialic acid biosynthesis.	N-Acetylneuraminic Acid	104-115	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	0-3
19458105-1	2009	The lectin Siglec-8 (sialic acid-binding, immunoglobulin-like lectin), which is selectively expressed on eosinophil surfaces and regulates eosinophil survival, preferentially binds to the glycan 6"-sulfo-sialyl Lewis X (6"-sulfo-sLe(x)).	N-Acetylneuraminic Acid	21-32	sialic acid binding Ig like lectin 8	Homo sapiens	11-19
19515783-8	2009	Consistent with the recognition of sialic acid moieties by the viral lectin HN, the binding of NKp44-Fc and NKp46-Fc was lost after desialylation.	N-Acetylneuraminic Acid	35-46	natural cytotoxicity triggering receptor 2	Homo sapiens	95-100
19515783-8	2009	Consistent with the recognition of sialic acid moieties by the viral lectin HN, the binding of NKp44-Fc and NKp46-Fc was lost after desialylation.	N-Acetylneuraminic Acid	35-46	natural cytotoxicity triggering receptor 1	Homo sapiens	108-113
19374421-7	2009	The structure of Neu5Ac bound in influenza neuraminidase ((4)S(2)/B(2,5)) belongs to conformations preferred in a water environment.	N-Acetylneuraminic Acid	17-23	neuraminidase 1	Homo sapiens	43-56
19426133-0	2009	Regulation and pathophysiological implications of UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) as the key enzyme of sialic acid biosynthesis.	N-Acetylneuraminic Acid	114-125	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	88-91
19426133-1	2009	The key enzyme for the biosynthesis of N-acetylneuraminic acid, from which all other sialic acids are formed, is the bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE).	N-Acetylneuraminic Acid	39-62	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	137-199
19426133-1	2009	The key enzyme for the biosynthesis of N-acetylneuraminic acid, from which all other sialic acids are formed, is the bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE).	N-Acetylneuraminic Acid	39-62	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	201-204
19666593-9	2009	First, inactivation of the CMAH gene in the human lineage rendered human ancestors unable to generate the sialic acid Neu5Gc from its precursor Neu5Ac, and likely made humans resistant to P. reichenowi.	N-Acetylneuraminic Acid	106-117	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	27-31
19666593-9	2009	First, inactivation of the CMAH gene in the human lineage rendered human ancestors unable to generate the sialic acid Neu5Gc from its precursor Neu5Ac, and likely made humans resistant to P. reichenowi.	N-Acetylneuraminic Acid	144-150	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	27-31
19506080-6	2009	Distinct from the human isoforms, the murine forms, to a different extent, both catalyzed the removal of sialic acid from gangliosides as well as glycoproteins, and one isoform seemed to act on polysialylated NCAM efficiently, despite the low activity toward ordinary substrates.	N-Acetylneuraminic Acid	105-116	neural cell adhesion molecule 1	Mus musculus	209-213
19592257-0	2009	Systematic syntheses of influenza neuraminidase inhibitors: a series of carbosilane dendrimers uniformly functionalized with thioglycoside-type sialic acid moieties.	N-Acetylneuraminic Acid	144-155	neuraminidase 1	Homo sapiens	34-47
19060786-7	2009	Thirty minutes after LPS stimulation, SA decreased LPS-enhanced endotoxin level, oxidative stress, alanine aminotransferase and aspartate aminotransferase levels, and cytokine concentration and ameliorated histopathologic alteration in the liver.	N-Acetylneuraminic Acid	38-40	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	128-154
19060786-8	2009	We found that SA increased LPS-depressed Mn-superoxide dismutase, CuZn-superoxide dismutase, and heat shock protein 70 and decreased LPS-enhanced iNOS and proapoptotic Bax protein expression in the liver by Western blot.	N-Acetylneuraminic Acid	14-16	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	97-118
19060786-8	2009	We found that SA increased LPS-depressed Mn-superoxide dismutase, CuZn-superoxide dismutase, and heat shock protein 70 and decreased LPS-enhanced iNOS and proapoptotic Bax protein expression in the liver by Western blot.	N-Acetylneuraminic Acid	14-16	nitric oxide synthase 2	Rattus norvegicus	146-150
19060786-8	2009	We found that SA increased LPS-depressed Mn-superoxide dismutase, CuZn-superoxide dismutase, and heat shock protein 70 and decreased LPS-enhanced iNOS and proapoptotic Bax protein expression in the liver by Western blot.	N-Acetylneuraminic Acid	14-16	BCL2 associated X, apoptosis regulator	Rattus norvegicus	168-171
19361277-3	2009	Sialic acids are synthesized in the cytosol starting from UDP-N-acetylglucosamine by the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE), which is the key enzyme in the biosynthesis of sialic acid that catalyzes the generation of N-acetylmannosamine, which in turn is an intermediate of the sialic acid pathway that represents the natural molecular precursor of all sialic acids.	N-Acetylneuraminic Acid	206-217	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	89-151
19361277-3	2009	Sialic acids are synthesized in the cytosol starting from UDP-N-acetylglucosamine by the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE), which is the key enzyme in the biosynthesis of sialic acid that catalyzes the generation of N-acetylmannosamine, which in turn is an intermediate of the sialic acid pathway that represents the natural molecular precursor of all sialic acids.	N-Acetylneuraminic Acid	206-217	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	153-156
19361277-3	2009	Sialic acids are synthesized in the cytosol starting from UDP-N-acetylglucosamine by the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE), which is the key enzyme in the biosynthesis of sialic acid that catalyzes the generation of N-acetylmannosamine, which in turn is an intermediate of the sialic acid pathway that represents the natural molecular precursor of all sialic acids.	N-Acetylneuraminic Acid	312-323	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	89-151
19361277-3	2009	Sialic acids are synthesized in the cytosol starting from UDP-N-acetylglucosamine by the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE), which is the key enzyme in the biosynthesis of sialic acid that catalyzes the generation of N-acetylmannosamine, which in turn is an intermediate of the sialic acid pathway that represents the natural molecular precursor of all sialic acids.	N-Acetylneuraminic Acid	312-323	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	153-156
19426133-8	2009	Due to the importance of increased concentrations of tumor-surface sialic acid, first attempts to find inhibitors of GNE have been successful.	N-Acetylneuraminic Acid	67-78	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	117-120
19406152-8	2009	This indicates that Sn is expressed on mouse AM but that the sialic acid binding activity mediated by this molecule is naturally masked by endogenous sialic acid within the glycocalyx on the cell surface.	N-Acetylneuraminic Acid	150-161	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	20-22
18975081-7	2009	Further analysis by ion-exchange chromatography revealed that rebamipide administration induced a specific increase in acidic mucin rich in sialic acid.	N-Acetylneuraminic Acid	140-151	LOC100508689	Homo sapiens	126-131
18937645-2	2009	Sialic acid linkages were identified for voltage-gated potassium channels, Kv3.1, 3.3, 3.4, 1.1, 1.2 and 1.4, by evaluating their electrophoretic migration patterns in adult rat brain membranes digested with various glycosidases.	N-Acetylneuraminic Acid	0-11	potassium voltage-gated channel subfamily C member 1	Rattus norvegicus	75-80
19557856-4	2009	Both patients were homozygous for the K136E mutation in SLC17A5, the gene responsible for the free sialic acid storage diseases.	N-Acetylneuraminic Acid	99-110	solute carrier family 17 member 5	Homo sapiens	56-63
24223493-7	2009	These novel sialic acid derivatives were then evaluated as potential neuraminidase inhibitors using a 96-well plate fluorescence assay; micromolar IC50 values were observed, comparable to the known sialidase inhibitor Neu5Ac2en.	N-Acetylneuraminic Acid	12-23	neuraminidase 1	Homo sapiens	69-82
24223493-0	2009	Synthesis and Biological Evaluation of Non-Hydrolizable 1,2,3-Triazole Linked Sialic Acid Derivatives as Neuraminidase Inhibitors.	N-Acetylneuraminic Acid	78-89	neuraminidase 1	Homo sapiens	105-118
24223493-2	2009	Our approach is to generate non-natural N-glycosides of sialic acid that are resistant to neuraminidase catalyzed hydrolysis as opposed to the natural O-glycosides.	N-Acetylneuraminic Acid	56-67	neuraminidase 1	Homo sapiens	90-103
19448634-4	2009	It is known that the disease gene underlying DMRV-hIBM is GNE, encoding glucosamine (UDP-N-acetyl)-2-epimerase and N-acetylmannosamine kinase6, 7, 8--two essential enzymes in sialic acid biosynthesis9.	N-Acetylneuraminic Acid	175-186	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	58-61
19190083-11	2009	Notably, alpha-2,6-linked sialic acid was associated with these mucin molecules and subsequent functional analysis showed that these vesicles have a neutralizing effect on human influenza virus, which is known to bind sialic acid.	N-Acetylneuraminic Acid	26-37	LOC100508689	Homo sapiens	64-69
19217912-3	2009	More specifically, it is thought that A beta interacts with ganglioside rich and sialic acid rich regions of cell surfaces.	N-Acetylneuraminic Acid	81-92	amyloid beta precursor protein	Homo sapiens	38-44
19240032-10	2009	Virtually all the sialic acid on GdC is located on the Sda antennae.	N-Acetylneuraminic Acid	18-29	solute carrier family 25 member 16	Homo sapiens	33-36
19217912-4	2009	In light of such evidence, we have used a number of different sialic acid compounds of different valency or number of sialic acid moieties per molecule to attenuate A beta toxicity in a cell culture model.	N-Acetylneuraminic Acid	118-129	amyloid beta precursor protein	Homo sapiens	165-171
19470179-4	2009	RESULTS: The cluster of genes encoding the enzymes N-acetylneuraminate lyase (NanA), epimerase (NanE), and kinase (NanK), necessary for the catabolism of sialic acid (the Nan cluster), are confined 46 bacterial species, 42 of which colonize mammals, 33 as pathogens and 9 as gut commensals.	N-Acetylneuraminic Acid	154-165	N-acetylneuraminate pyruvate lyase	Homo sapiens	51-76
19470179-4	2009	RESULTS: The cluster of genes encoding the enzymes N-acetylneuraminate lyase (NanA), epimerase (NanE), and kinase (NanK), necessary for the catabolism of sialic acid (the Nan cluster), are confined 46 bacterial species, 42 of which colonize mammals, 33 as pathogens and 9 as gut commensals.	N-Acetylneuraminic Acid	154-165	N-acetylneuraminate pyruvate lyase	Homo sapiens	78-82
19217912-4	2009	In light of such evidence, we have used a number of different sialic acid compounds of different valency or number of sialic acid moieties per molecule to attenuate A beta toxicity in a cell culture model.	N-Acetylneuraminic Acid	62-73	amyloid beta precursor protein	Homo sapiens	165-171
19217912-5	2009	In this work, we proposed various mathematical models of A beta interaction with both the cell membrane and with the multivalent sialic acid compounds, designed to act as membrane mimics.	N-Acetylneuraminic Acid	129-140	amyloid beta precursor protein	Homo sapiens	57-63
19217912-6	2009	These models allow us to explore the mechanism of action of this class of sialic acid membrane mimics in attenuating the toxicity of A beta.	N-Acetylneuraminic Acid	74-85	amyloid beta precursor protein	Homo sapiens	133-139
19337729-1	2009	The CD33-related sialic acid binding Ig-like lectins (CD33rSiglecs) are predominantly inhibitory receptors expressed on leukocytes.	N-Acetylneuraminic Acid	17-28	CD33 molecule	Homo sapiens	4-8
19458237-2	2009	Here, we show that promotion or inhibition of neurite outgrowth of cerebellar or dorsal root ganglion neurons, respectively, induced by the mucin-type adhesion molecule CD24 depends on alpha2,3-linked sialic acid and Lewis(x) present on glia-specific CD24 glycoforms.	N-Acetylneuraminic Acid	201-212	CD24 molecule	Homo sapiens	169-173
19572026-6	2009	We determined that DeltaF508 CFTR is associated with decreased membrane sialic acid residues in the alpha2, 3 position and increased concentrations of asialo- G(M1).	N-Acetylneuraminic Acid	72-83	CF transmembrane conductance regulator	Homo sapiens	29-33
19392624-4	2009	Competition of both sialic acid-dependent phenotypes was found to be successful when evaluated using the neuraminidase inhibitors DANA (i.e., 2,3-didehydro-2-deoxy-N-acetylneuraminic acid), zanamivir, and oseltamivir.	N-Acetylneuraminic Acid	20-31	neuraminidase 1	Homo sapiens	105-118
19392624-5	2009	The association between levels of free sialic acid on mucosae, pneumococcal colonization, and development of invasive disease shows how a host-derived molecule can influence a colonizing microbe and also highlights a molecular mechanism that explains the epidemiologic correlation between respiratory infections due to neuraminidase-bearing viruses and bacterial pneumonia.	N-Acetylneuraminic Acid	39-50	neuraminidase 1	Homo sapiens	319-332
19303396-0	2009	NKG2D and CD94 bind to multimeric alpha2,3-linked N-acetylneuraminic acid.	N-Acetylneuraminic Acid	50-73	killer cell lectin like receptor K1	Homo sapiens	0-5
19303396-0	2009	NKG2D and CD94 bind to multimeric alpha2,3-linked N-acetylneuraminic acid.	N-Acetylneuraminic Acid	50-73	killer cell lectin like receptor D1	Homo sapiens	10-14
19303396-4	2009	The binding of rNKG2Dlec and rCD94lec to HepTF was markedly suppressed by treatment of HepTF with neuraminidase and in the presence of N-acetylneuraminic acid.	N-Acetylneuraminic Acid	135-158	killer cell lectin like receptor D1	Rattus norvegicus	29-34
19414805-3	2009	We show here that sialoadhesin (Sn), the prototype of the siglec family of sialic acid-binding transmembrane proteins, expressed by resident and activated tissue-infiltrating macrophages, directly binds to Tregs, negatively regulating their expansion in an animal model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE).	N-Acetylneuraminic Acid	75-86	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	18-30
19414805-3	2009	We show here that sialoadhesin (Sn), the prototype of the siglec family of sialic acid-binding transmembrane proteins, expressed by resident and activated tissue-infiltrating macrophages, directly binds to Tregs, negatively regulating their expansion in an animal model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE).	N-Acetylneuraminic Acid	75-86	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	32-34
19414805-9	2009	We propose a new direct cell-cell interaction-based mechanism regulating the expansion of the Tregs during the immune response, representing a "dialogue" between Sn(+) macrophages and Sn-accessible sialic acid residues on Treg lymphocytes.	N-Acetylneuraminic Acid	198-209	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	184-186
19361194-7	2009	Kinetic analysis of the degradation reactions suggested that the sialic acid component played an important role in decreasing the affinity of peptide to DPP-IV.	N-Acetylneuraminic Acid	65-76	dipeptidylpeptidase 4	Mus musculus	153-159
19420245-1	2009	Myelin-associated glycoprotein (MAG) is a sialic acid-binding Ig-family lectin that functions in neuronal growth inhibition and stabilization of axon-glia interactions.	N-Acetylneuraminic Acid	42-53	myelin associated glycoprotein	Homo sapiens	0-30
19420245-1	2009	Myelin-associated glycoprotein (MAG) is a sialic acid-binding Ig-family lectin that functions in neuronal growth inhibition and stabilization of axon-glia interactions.	N-Acetylneuraminic Acid	42-53	myelin associated glycoprotein	Homo sapiens	32-35
19420245-3	2009	We show that the first three Ig-like domains of MAG bind with high affinity and in a sialic acid-dependent manner to the Nogo-66 receptor-1 (NgR1) and its homolog NgR2.	N-Acetylneuraminic Acid	85-96	myelin associated glycoprotein	Homo sapiens	48-51
19420245-3	2009	We show that the first three Ig-like domains of MAG bind with high affinity and in a sialic acid-dependent manner to the Nogo-66 receptor-1 (NgR1) and its homolog NgR2.	N-Acetylneuraminic Acid	85-96	reticulon 4 receptor	Homo sapiens	121-137
19420245-3	2009	We show that the first three Ig-like domains of MAG bind with high affinity and in a sialic acid-dependent manner to the Nogo-66 receptor-1 (NgR1) and its homolog NgR2.	N-Acetylneuraminic Acid	85-96	reticulon 4 receptor like 2	Homo sapiens	163-167
19281805-7	2009	Monitoring the pattern of transferrin bound sialic acid residues may thus be a helpful tool in assessing the risk of malignant degeneration in patients with chronic fibrogenic liver disease.	N-Acetylneuraminic Acid	44-55	transferrin	Homo sapiens	26-37
19522249-2	2009	We investigated the effects of a sialic acid moiety of apoE on the apoE-Abeta interaction using the surface plasmon resonance assay.	N-Acetylneuraminic Acid	33-44	apolipoprotein E	Homo sapiens	55-59
19470101-3	2009	In this study, we report that the At3g48820 gene (Gene ID: 824043) codes for a Golgi resident protein lacking the ability to transfer SA to asialofetuin or Galbeta1,3GalNAc and Galbeta1,4GlcNAc oligosaccharide acceptors.	N-Acetylneuraminic Acid	134-136	Glycosyltransferase family 29 (sialyltransferase) family protein	Arabidopsis thaliana	34-43
19522249-2	2009	We investigated the effects of a sialic acid moiety of apoE on the apoE-Abeta interaction using the surface plasmon resonance assay.	N-Acetylneuraminic Acid	33-44	apolipoprotein E	Homo sapiens	67-71
19522249-2	2009	We investigated the effects of a sialic acid moiety of apoE on the apoE-Abeta interaction using the surface plasmon resonance assay.	N-Acetylneuraminic Acid	33-44	amyloid beta precursor protein	Homo sapiens	72-77
19522249-3	2009	Further, we established a method for the determination of the sialic acid content of CSF apoE, and carried out a more detailed characterization of CSF apoE-containing lipoproteins.	N-Acetylneuraminic Acid	62-73	apolipoprotein E	Homo sapiens	89-93
19522249-6	2009	The sialic acid levels in the CSF apoE-containing lipoprotein fractions were 5.3 +/- 1.3% of the total CSF sialic acid, and were correlated with the CSF apoE concentrations.	N-Acetylneuraminic Acid	4-15	apolipoprotein E	Homo sapiens	34-38
19508372-1	2009	We recently showed that the acute-phase protein alpha(1)-acid glycoprotein (AGP) induces rises in cytosolic calcium concentration, [Ca(2+)](i,) in neutrophils through sialic acid dependent interactions with the neutrophil receptors siglec-5 and/or siglec-14.	N-Acetylneuraminic Acid	167-178	sialic acid binding Ig like lectin 5	Homo sapiens	232-240
19522249-6	2009	The sialic acid levels in the CSF apoE-containing lipoprotein fractions were 5.3 +/- 1.3% of the total CSF sialic acid, and were correlated with the CSF apoE concentrations.	N-Acetylneuraminic Acid	4-15	apolipoprotein E	Homo sapiens	153-157
19508372-1	2009	We recently showed that the acute-phase protein alpha(1)-acid glycoprotein (AGP) induces rises in cytosolic calcium concentration, [Ca(2+)](i,) in neutrophils through sialic acid dependent interactions with the neutrophil receptors siglec-5 and/or siglec-14.	N-Acetylneuraminic Acid	167-178	sialic acid binding Ig like lectin 14	Homo sapiens	248-257
19522249-6	2009	The sialic acid levels in the CSF apoE-containing lipoprotein fractions were 5.3 +/- 1.3% of the total CSF sialic acid, and were correlated with the CSF apoE concentrations.	N-Acetylneuraminic Acid	107-118	apolipoprotein E	Homo sapiens	34-38
19508372-2	2009	Whereas both siglec-5 and siglec-14 have a relatively broad specificity for sialylated oligosaccharide structures, including both structures with terminal alpha2-3 or alpha2-6 linked sialic acid, there is a markedly reduced affinity to the fucosylated epitope sialyl Lewis x (SLe(x)).	N-Acetylneuraminic Acid	183-194	sialic acid binding Ig like lectin 5	Homo sapiens	13-21
19508372-2	2009	Whereas both siglec-5 and siglec-14 have a relatively broad specificity for sialylated oligosaccharide structures, including both structures with terminal alpha2-3 or alpha2-6 linked sialic acid, there is a markedly reduced affinity to the fucosylated epitope sialyl Lewis x (SLe(x)).	N-Acetylneuraminic Acid	183-194	sialic acid binding Ig like lectin 14	Homo sapiens	26-35
19508372-7	2009	The role of the carbohydrate portion of AGP in modulating neutrophil responses was further strengthened by showing that synthetic glycoconjugates carrying oligosaccharides with terminal alpha2-3 or alpha2-6 linked sialic acid were able to mimic the Ca(2+)-mobilizing effect of AGP whereas a synthetic glycoconjugate carrying SLe(x) was not.	N-Acetylneuraminic Acid	214-225	immunoglobulin binding protein 1	Homo sapiens	198-206
19522249-9	2009	The sialic acid moiety of the apoE molecules affects the interaction of apoE with Abeta and the formation of apoE-containing lipoprotein particles.	N-Acetylneuraminic Acid	4-15	apolipoprotein E	Homo sapiens	30-34
19522249-9	2009	The sialic acid moiety of the apoE molecules affects the interaction of apoE with Abeta and the formation of apoE-containing lipoprotein particles.	N-Acetylneuraminic Acid	4-15	apolipoprotein E	Homo sapiens	72-76
19522249-9	2009	The sialic acid moiety of the apoE molecules affects the interaction of apoE with Abeta and the formation of apoE-containing lipoprotein particles.	N-Acetylneuraminic Acid	4-15	amyloid beta precursor protein	Homo sapiens	82-87
19522249-9	2009	The sialic acid moiety of the apoE molecules affects the interaction of apoE with Abeta and the formation of apoE-containing lipoprotein particles.	N-Acetylneuraminic Acid	4-15	apolipoprotein E	Homo sapiens	72-76
19522249-10	2009	The posttranslational modification of apoE, such as the presence of sialic acid moieties, may be involved in the regulation of lipid transport to the brain.	N-Acetylneuraminic Acid	68-79	apolipoprotein E	Homo sapiens	38-42
19242346-1	2009	OBJECTIVE: To investigate the influence of neuraminidase, an enzyme that cleaves sialic acid from the red blood cell (RBC) membrane, on RBC shape and biochemistry in critically ill patients.	N-Acetylneuraminic Acid	81-92	neuraminidase 1	Homo sapiens	43-56
19007360-2	2009	PATIENTS, SUBJECTS AND METHODS: The sialic acid content of THP, a critical component of its biological activity, is reduced in patients with IC.	N-Acetylneuraminic Acid	36-47	uromodulin	Homo sapiens	59-62
19135419-1	2009	Siglec-F is a sialic acid binding immunoglobulin-superfamily receptor that is highly expressed on eosinophils.	N-Acetylneuraminic Acid	14-25	sialic acid binding Ig-like lectin F	Mus musculus	0-8
19138682-0	2009	Sialic acid moiety of apolipoprotein E and its impact on the formation of lipoprotein particles in human cerebrospinal fluid.	N-Acetylneuraminic Acid	0-11	apolipoprotein E	Homo sapiens	22-38
19138682-1	2009	BACKGROUND: Apolipoprotein (apo) E in the cerebrospinal fluid (CSF) is abundant with sialic acid (SA), and sialylation of certain proteins is known to modulate biological function.	N-Acetylneuraminic Acid	85-96	apolipoprotein E	Homo sapiens	12-34
19138682-1	2009	BACKGROUND: Apolipoprotein (apo) E in the cerebrospinal fluid (CSF) is abundant with sialic acid (SA), and sialylation of certain proteins is known to modulate biological function.	N-Acetylneuraminic Acid	98-100	apolipoprotein E	Homo sapiens	12-34
19138682-2	2009	The aim of the present study was to quantify the SA content in CSF apoE and carry out the more detailed characterization of the CSF apoE-containing lipoproteins.	N-Acetylneuraminic Acid	49-51	apolipoprotein E	Homo sapiens	67-71
19138682-3	2009	METHODS: The method for the determination of the SA in CSF apoE was based on the conversion of SA into p-aminobenzoic acid ethyl ester-derivatized N-acetylmannosamine, followed by HPLC analysis.	N-Acetylneuraminic Acid	49-51	apolipoprotein E	Homo sapiens	59-63
19138682-3	2009	METHODS: The method for the determination of the SA in CSF apoE was based on the conversion of SA into p-aminobenzoic acid ethyl ester-derivatized N-acetylmannosamine, followed by HPLC analysis.	N-Acetylneuraminic Acid	95-97	apolipoprotein E	Homo sapiens	59-63
19138682-5	2009	The SA levels in the CSF apoE-containing lipoprotein fractions were 5.3+/-1.3% of total CSF SA, and were correlated with the CSF apoE concentrations.	N-Acetylneuraminic Acid	4-6	apolipoprotein E	Homo sapiens	25-29
19138682-5	2009	The SA levels in the CSF apoE-containing lipoprotein fractions were 5.3+/-1.3% of total CSF SA, and were correlated with the CSF apoE concentrations.	N-Acetylneuraminic Acid	4-6	apolipoprotein E	Homo sapiens	129-133
19138682-5	2009	The SA levels in the CSF apoE-containing lipoprotein fractions were 5.3+/-1.3% of total CSF SA, and were correlated with the CSF apoE concentrations.	N-Acetylneuraminic Acid	92-94	apolipoprotein E	Homo sapiens	25-29
19138682-8	2009	CONCLUSION: The SA moiety of the CSF apoE molecules may affect the formation of the apoE-containing lipoprotein particles and the regulation of lipid delivery in CNS.	N-Acetylneuraminic Acid	16-18	apolipoprotein E	Homo sapiens	37-41
19138682-8	2009	CONCLUSION: The SA moiety of the CSF apoE molecules may affect the formation of the apoE-containing lipoprotein particles and the regulation of lipid delivery in CNS.	N-Acetylneuraminic Acid	16-18	apolipoprotein E	Homo sapiens	84-88
18777136-3	2009	An inactivating mutation in the CMAH gene eliminated human expression of N-glycolylneuraminic acid (Neu5Gc) a major sialic acid in "great apes".	N-Acetylneuraminic Acid	116-127	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	32-36
19353608-1	2009	A regio- and stereocontrolled solution for a selective modification at the C-2 or C-4 position of N-acetylneuraminic acid involves the use of allylic substitution catalyzed by palladium.	N-Acetylneuraminic Acid	98-121	complement C2	Homo sapiens	75-78
19057931-3	2009	Furthermore, the docking results of the substrates (sialic acid and KDO) into the active site of hNAL indicate that hNAL can cleave the sialic acid and KDO.	N-Acetylneuraminic Acid	52-63	N-acetylneuraminate pyruvate lyase	Homo sapiens	97-101
19057931-3	2009	Furthermore, the docking results of the substrates (sialic acid and KDO) into the active site of hNAL indicate that hNAL can cleave the sialic acid and KDO.	N-Acetylneuraminic Acid	52-63	N-acetylneuraminate pyruvate lyase	Homo sapiens	116-120
19057931-3	2009	Furthermore, the docking results of the substrates (sialic acid and KDO) into the active site of hNAL indicate that hNAL can cleave the sialic acid and KDO.	N-Acetylneuraminic Acid	136-147	N-acetylneuraminate pyruvate lyase	Homo sapiens	97-101
19057931-3	2009	Furthermore, the docking results of the substrates (sialic acid and KDO) into the active site of hNAL indicate that hNAL can cleave the sialic acid and KDO.	N-Acetylneuraminic Acid	136-147	N-acetylneuraminate pyruvate lyase	Homo sapiens	116-120
19057931-6	2009	From the docking studies, we also suggest that Asp176 and Ser218 only form hydrogen bonds with sialic acid, therefore, they may help sialic acid interact with hNAL steadly.	N-Acetylneuraminic Acid	95-106	N-acetylneuraminate pyruvate lyase	Homo sapiens	159-163
19057931-6	2009	From the docking studies, we also suggest that Asp176 and Ser218 only form hydrogen bonds with sialic acid, therefore, they may help sialic acid interact with hNAL steadly.	N-Acetylneuraminic Acid	133-144	N-acetylneuraminate pyruvate lyase	Homo sapiens	159-163
19121622-1	2009	Bacterial neuraminidase, a sialic acid-degrading enzyme, is one of the virulent factors produced in pathogenic bacteria like as other bacterial components.	N-Acetylneuraminic Acid	27-38	neuraminidase 1	Homo sapiens	10-23
18925876-1	2009	CD22 [Siglec-2 (sialic acid-binding, immunoglobulin-like lectin-2)], a negative regulator of B-cell signalling, binds to alpha2,6- sialic acid-linked glycoconjugates, including a sialyl-Tn antigen that is one of the typical tumour-associated carbohydrate antigens expressed on various mucins.	N-Acetylneuraminic Acid	16-27	CD22 antigen	Mus musculus	0-4
18925876-1	2009	CD22 [Siglec-2 (sialic acid-binding, immunoglobulin-like lectin-2)], a negative regulator of B-cell signalling, binds to alpha2,6- sialic acid-linked glycoconjugates, including a sialyl-Tn antigen that is one of the typical tumour-associated carbohydrate antigens expressed on various mucins.	N-Acetylneuraminic Acid	16-27	CD22 antigen	Mus musculus	6-14
19136890-12	2009	Competing terminal sugars expressed on human aortic endothelial cells such as sialic acid, may block galectin-3 binding.	N-Acetylneuraminic Acid	78-89	galectin 3	Homo sapiens	101-111
19575597-2	2009	Sialic acid (Sia) is an essential component of brain gangliosides and the polysialic acid (polySia) chains that modify neural cell adhesion molecules (NCAM).	N-Acetylneuraminic Acid	0-11	neural cell adhesion molecule 1	Homo sapiens	151-155
19575597-2	2009	Sialic acid (Sia) is an essential component of brain gangliosides and the polysialic acid (polySia) chains that modify neural cell adhesion molecules (NCAM).	N-Acetylneuraminic Acid	0-3	neural cell adhesion molecule 1	Homo sapiens	151-155
19458903-2	2009	The neuraminidase (NA) of the avian viruses has, in addition to the catalytic site, a separate sialic acid binding site (hemadsorption site) that is not present in human viruses.	N-Acetylneuraminic Acid	95-106	neuraminidase 1	Homo sapiens	4-17
18757189-1	2009	A novel lectin (PCL) with specificity towards sialic acid was purified from Phaseolus coccineus L. (P. multiflorus willd) seeds using ion exchange chromatography on CM and DEAE-Sepharose, and gel filtration on Sephacryl S-200 column.	N-Acetylneuraminic Acid	46-57	polycystic kidney disease 2-like 1	Mus musculus	16-19
19322776-5	2009	Furthermore, subsequent validation experiments using an additional set of 60 lung adenocarcinoma patients and 30 normal controls demonstrated that there is a higher frequency of serum apoC-III with loss of alpha2,6-linkage Neu5Ac residues in lung cancer patients compared to controls.	N-Acetylneuraminic Acid	223-229	apolipoprotein C3	Homo sapiens	184-192
19151752-8	2009	Treatment of the cells with GalNAc-alpha-O-benzyl, an inhibitor of O-glycosylation, showed increased PNA-positive integrin beta4 with its decreased phosphorylation, indicating that sialic acid removal from the integrin O-glycans results in the decreased phosphorylation.	N-Acetylneuraminic Acid	181-192	integrin subunit beta 4	Homo sapiens	114-128
19153153-5	2009	Two-dimensional gel analyses revealed significant hyposialylation of transferrin in CSF of all patients compared to age-matched controls (P &lt; 0.001)--a finding not present in the CSF of patients with Salla disease, the most common free sialic acid storage disorder.	N-Acetylneuraminic Acid	239-250	transferrin	Homo sapiens	69-80
19043084-1	2009	Isolation of salivary MUC7 with gel electrophoresis allowed analysis by LC-MS and LC-MS(2) of released O-linked oligosaccharides and a thorough description of the glycosylation of this molecule, where high-molecular-weight oligosaccharides up to the size of 2790 Da and with up to three sialic acid residues were identified.	N-Acetylneuraminic Acid	287-298	mucin 7, secreted	Homo sapiens	22-26
19418726-6	2009	Our results suggest that altered expression of ST3Gal III, ST3Gal IV and ST6Gal I in CIN could play an important role during malignant transformation and could be related with the enhanced sialic acid expression detected in neoplasic tissues.	N-Acetylneuraminic Acid	189-200	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	47-57
19418726-6	2009	Our results suggest that altered expression of ST3Gal III, ST3Gal IV and ST6Gal I in CIN could play an important role during malignant transformation and could be related with the enhanced sialic acid expression detected in neoplasic tissues.	N-Acetylneuraminic Acid	189-200	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	59-68
19418726-6	2009	Our results suggest that altered expression of ST3Gal III, ST3Gal IV and ST6Gal I in CIN could play an important role during malignant transformation and could be related with the enhanced sialic acid expression detected in neoplasic tissues.	N-Acetylneuraminic Acid	189-200	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	73-81
19221437-4	2009	The cryptic GM1 binding domain was exposed by sialidase treatment that liberated sialic acid from masking gangliosides including GD1a or by disruption of the live membrane by freezing or fixation.	N-Acetylneuraminic Acid	81-92	coenzyme Q10A	Mus musculus	12-15
19175312-0	2009	Examination of the biological role of the alpha(2--&gt;6)-linked sialic acid in gangliosides binding to the myelin-associated glycoprotein (MAG).	N-Acetylneuraminic Acid	65-76	myelin associated glycoprotein	Homo sapiens	108-138
19175312-0	2009	Examination of the biological role of the alpha(2--&gt;6)-linked sialic acid in gangliosides binding to the myelin-associated glycoprotein (MAG).	N-Acetylneuraminic Acid	65-76	myelin associated glycoprotein	Homo sapiens	140-143
19175312-4	2009	Combined with a core modification and the earlier found aryl amide substituent in the 9-position of the alpha(2--&gt;3)-linked sialic acid, high affinity MAG antagonists were identified.	N-Acetylneuraminic Acid	127-138	myelin associated glycoprotein	Homo sapiens	154-157
19123788-3	2009	Besides 22 and 20 kDa isoforms, fragments of 9 and 12 kDa were identified and a glycosylated 23 kDa GH variant was elucidated to bear a HexHexNac 2 NeuAc modification presumably located at Thr 60.	N-Acetylneuraminic Acid	148-153	growth hormone 1	Homo sapiens	100-102
19103880-3	2009	The 9-O-acetylation state of sialic acid regulates the function of CD22, a Siglec that functions in vivo as an inhibitor of BCR signaling.	N-Acetylneuraminic Acid	29-40	CD22 antigen	Mus musculus	67-71
19322854-1	2009	Total synthesis through block glycosylation and selective chemical O-sulfation of tyrosine residues yielded the glycopeptide recognition domain A (X=SO(3) (-)) of the P-selectin glycoprotein ligand 1, in which the terminal sialic acid of the complex hexasaccharide side chain was replaced by (S)-cyclohexyl lactic acid.	N-Acetylneuraminic Acid	223-234	selectin P ligand	Homo sapiens	167-199
19353608-1	2009	A regio- and stereocontrolled solution for a selective modification at the C-2 or C-4 position of N-acetylneuraminic acid involves the use of allylic substitution catalyzed by palladium.	N-Acetylneuraminic Acid	98-121	complement C4A (Rodgers blood group)	Homo sapiens	82-85
18388037-0	2008	Association between protein-bound sialic acid and high-sensitivity C-reactive protein in essential hypertension: a possible indication of underlying cardiovascular risk.	N-Acetylneuraminic Acid	34-45	C-reactive protein	Homo sapiens	67-85
19768409-1	2009	The neuraminidase protein of influenza viruses is a surface glycoprotein that shows enzymatic activity to remove sialic acid, the viral receptor, from both viral and host proteins.	N-Acetylneuraminic Acid	113-124	neuraminidase 1	Homo sapiens	4-17
19768409-9	2009	The neuraminidase protein has also become an important target for antiviral drugs that target sialic acid binding which blocks neuraminidase enzyme activity.	N-Acetylneuraminic Acid	94-105	neuraminidase 1	Homo sapiens	4-17
19768409-9	2009	The neuraminidase protein has also become an important target for antiviral drugs that target sialic acid binding which blocks neuraminidase enzyme activity.	N-Acetylneuraminic Acid	94-105	neuraminidase 1	Homo sapiens	127-140
18388037-5	2008	Correlation analysis revealed a significant association between the protein-bound sialic acid with mean arterial pressure, C-reactive protein, and low-density lipoprotein-cholesterol.	N-Acetylneuraminic Acid	82-93	C-reactive protein	Homo sapiens	123-141
18388037-6	2008	The findings of the present study suggest that in essential hypertension there is an association between protein-bound sialic acid and C-reactive protein, which reflects the clustering of cardiovascular risk factors in these patients.	N-Acetylneuraminic Acid	119-130	C-reactive protein	Homo sapiens	135-153
18722069-1	2008	The terminal sialic acid of human erythropoietin (hEPO) is essential for in vivo activity.	N-Acetylneuraminic Acid	13-24	erythropoietin	Homo sapiens	34-48
19131698-5	2008	When alpha2,3-ST was expressed in CHO cells (EC1-ST2), the sialic acid content (moles of sialic acid/mole of EPO) increased from 6.7 to 7.5.	N-Acetylneuraminic Acid	59-70	erythropoietin	Cricetulus griseus	109-112
18723858-2	2008	Although the causing gene, GNE, encodes for a key enzyme in the biosynthesis of sialic acid, its primary function in HIBM remains unknown.	N-Acetylneuraminic Acid	80-91	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	27-30
18703820-5	2008	MRM detection specific for sialic acid enabled us to analyze ganglioside standards such as GM1, GM2, GM3, GD1, and GT1 at picomolar to femtomolar levels.	N-Acetylneuraminic Acid	27-38	cytochrome b5 domain containing 2	Mus musculus	96-99
18703820-5	2008	MRM detection specific for sialic acid enabled us to analyze ganglioside standards such as GM1, GM2, GM3, GD1, and GT1 at picomolar to femtomolar levels.	N-Acetylneuraminic Acid	27-38	granulocyte macrophage antigen 3	Mus musculus	101-104
18703820-5	2008	MRM detection specific for sialic acid enabled us to analyze ganglioside standards such as GM1, GM2, GM3, GD1, and GT1 at picomolar to femtomolar levels.	N-Acetylneuraminic Acid	27-38	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	115-118
18722069-1	2008	The terminal sialic acid of human erythropoietin (hEPO) is essential for in vivo activity.	N-Acetylneuraminic Acid	13-24	erythropoietin	Homo sapiens	50-54
18653764-2	2008	Sialuria is a dominant disorder caused by missense mutations in the allosteric site of GNE, coding for the rate-limiting enzyme of sialic acid biosynthesis, UDP-GlcNAc 2-epimerase/ManNAc kinase.	N-Acetylneuraminic Acid	131-142	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	87-90
18924218-7	2008	The sialic acid moiety of the GBS capsule was crucial for its ability to prevent recognition by SR-A.	N-Acetylneuraminic Acid	4-15	macrophage scavenger receptor 1	Mus musculus	96-100
18653764-2	2008	Sialuria is a dominant disorder caused by missense mutations in the allosteric site of GNE, coding for the rate-limiting enzyme of sialic acid biosynthesis, UDP-GlcNAc 2-epimerase/ManNAc kinase.	N-Acetylneuraminic Acid	131-142	renin binding protein	Homo sapiens	161-179
18653764-3	2008	The resultant loss of feedback inhibition of GNE-epimerase activity by CMP-sialic acid causes excessive production of free sialic acid.	N-Acetylneuraminic Acid	75-86	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	45-48
18653764-3	2008	The resultant loss of feedback inhibition of GNE-epimerase activity by CMP-sialic acid causes excessive production of free sialic acid.	N-Acetylneuraminic Acid	123-134	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	45-48
18653764-7	2008	Feedback inhibition of GNE-epimerase activity by CMP-sialic acid recovered after silencing demonstrating specificity of this effect.	N-Acetylneuraminic Acid	53-64	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	23-26
18989465-9	2008	Podoplanin is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property.	N-Acetylneuraminic Acid	110-121	podoplanin	Mus musculus	0-10
18713811-5	2008	Biochemical analyses indicate that recombinant interferon-gamma (IFN-gamma) produced by the mutant cells lack sialic acid.	N-Acetylneuraminic Acid	110-121	interferon gamma	Cricetulus griseus	47-63
18713811-5	2008	Biochemical analyses indicate that recombinant interferon-gamma (IFN-gamma) produced by the mutant cells lack sialic acid.	N-Acetylneuraminic Acid	110-121	interferon gamma	Cricetulus griseus	65-74
18673349-2	2008	Neuraminidase released by the pneumococci may cleave N-acetylneuraminic acid residues on red blood cells (RBCs), leading to the exposure of the T cryptantigen and polyagglutinability of RBCs, a process known as T activation.	N-Acetylneuraminic Acid	53-76	neuraminidase 1	Homo sapiens	0-13
18808170-2	2008	In this paper, we have examined this question using antibodies directed to Sialoadhesin (Sn), a macrophage-restricted adhesion molecule that mediates sialic acid dependent binding to different cells.	N-Acetylneuraminic Acid	150-161	sialic acid binding Ig like lectin 1	Homo sapiens	75-87
18689602-9	2008	The elastic lamellae in the aorta of the Neu1-null mice were thinner and separated by hypertrophic smooth muscle cells that were surrounded by an excess of the sialic acid-containing moieties.	N-Acetylneuraminic Acid	160-171	neuraminidase 1	Mus musculus	41-45
18808170-2	2008	In this paper, we have examined this question using antibodies directed to Sialoadhesin (Sn), a macrophage-restricted adhesion molecule that mediates sialic acid dependent binding to different cells.	N-Acetylneuraminic Acid	150-161	sialic acid binding Ig like lectin 1	Homo sapiens	89-91
18678668-5	2008	Using a glutathione S-transferase (GST) fusion to the NR2 domain, which is the sialic acid-binding region of Hsa, we confirmed that the Hsa NR2 domain also binds to differentiated HL-60 cells.	N-Acetylneuraminic Acid	79-90	glutathione S-transferase kappa 1	Homo sapiens	8-33
18678668-5	2008	Using a glutathione S-transferase (GST) fusion to the NR2 domain, which is the sialic acid-binding region of Hsa, we confirmed that the Hsa NR2 domain also binds to differentiated HL-60 cells.	N-Acetylneuraminic Acid	79-90	glutathione S-transferase kappa 1	Homo sapiens	35-38
18701332-3	2008	AGP was purified from serum and Western blotting followed by lectin-staining of alpha(2,3)-linked and alpha(2,6)-linked sialic acid.	N-Acetylneuraminic Acid	120-131	alpha-1-acid glycoprotein	Felis catus	0-3
18490007-7	2008	Fucosylation was markedly increased, while O-acetylation of sialic acid was found to be decreased in PH-FN.	N-Acetylneuraminic Acid	60-71	fibronectin 1	Rattus norvegicus	104-106
18700760-0	2008	13C-sialic acid labeling of glycans on glycoproteins using ST6Gal-I.	N-Acetylneuraminic Acid	4-15	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	59-67
18700760-4	2008	Here an approach is presented that that uses alpha-2,6-sialyltransferase (ST6Gal-I) to enzymatically add 13C-N-acetylneuraminic acid (NeuAc or sialic acid) to glycoproteins after their preparation using nonbacterial hosts.	N-Acetylneuraminic Acid	134-139	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	74-82
18700760-4	2008	Here an approach is presented that that uses alpha-2,6-sialyltransferase (ST6Gal-I) to enzymatically add 13C-N-acetylneuraminic acid (NeuAc or sialic acid) to glycoproteins after their preparation using nonbacterial hosts.	N-Acetylneuraminic Acid	143-154	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	74-82
18700760-9	2008	Chemical shift dispersion due to the various 13C-NeuAc adducts on ST6Gal-I was observed in a 3D experiment correlating 1H-13C3-13C2 atoms of the sugar ring.	N-Acetylneuraminic Acid	49-54	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	66-74
19019317-1	2008	Hereditary inclusion body myopathy (HIBM) is a genetic muscle disease due to mutations in the gene encoding the enzyme complex UDP-N-acetylglucosamine 2 epimerase-N-acetylmannosamine kinase (GNE), which catalyzes the rate-limiting step in sialic acid production.	N-Acetylneuraminic Acid	239-250	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	127-189
19019317-1	2008	Hereditary inclusion body myopathy (HIBM) is a genetic muscle disease due to mutations in the gene encoding the enzyme complex UDP-N-acetylglucosamine 2 epimerase-N-acetylmannosamine kinase (GNE), which catalyzes the rate-limiting step in sialic acid production.	N-Acetylneuraminic Acid	239-250	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	191-194
18628337-2	2008	It is caused by mutations in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene that is important in sialic acid synthesis.	N-Acetylneuraminic Acid	128-139	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	33-95
18628337-2	2008	It is caused by mutations in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene that is important in sialic acid synthesis.	N-Acetylneuraminic Acid	128-139	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	97-100
18399798-0	2008	Molecular pathogenesis of sialic acid storage diseases: insight gained from four missense mutations and a putative polymorphism of human sialin.	N-Acetylneuraminic Acid	26-37	solute carrier family 17 member 5	Homo sapiens	137-143
18399798-1	2008	BACKGROUND INFORMATION: Free sialic acid storage diseases are caused by mutations of a lysosomal sialic acid transporter called sialin.	N-Acetylneuraminic Acid	29-40	solute carrier family 17 member 5	Homo sapiens	128-134
21136920-8	2008	Moreover, one of the most typical enzymes, ST6Gal1, which transfers Neu5Ac residues in alpha2-6 linkage to Gal beta1-4GlcNAc units on N-glycans, is significantly less expressed in juvenile GIST.	N-Acetylneuraminic Acid	68-74	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	43-50
18081697-3	2008	The oligosaccharide side chains of Paget cell mucin end with sialic acid.	N-Acetylneuraminic Acid	61-72	LOC100508689	Homo sapiens	46-51
18682981-0	2008	Asthma induction in mice leads to appearance of alpha2-3- and alpha2-6-linked sialic acid residues in respiratory goblet-like cells.	N-Acetylneuraminic Acid	78-89	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	62-70
18682981-2	2008	Immunohistochemistry was used to demonstrate binding of lectins and antibodies that detect alpha2-3- and alpha2-6-linked sialic acid residues.	N-Acetylneuraminic Acid	121-132	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	105-113
18682981-4	2008	Normal Clara cells showed no reaction after incubation with the sialic acid detecting agents, while the goblet-like cells expressed both alpha2-3- and alpha2-6-linked sialic acid residues in the asthmatic animals.	N-Acetylneuraminic Acid	167-178	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	151-159
18258224-6	2008	One of these is the Chinese hamster ovary cell line Lec2, deficient in CMP-sialic acid transport to the Golgi lumen.	N-Acetylneuraminic Acid	75-86	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	52-56
18258224-8	2008	Using expression cloning, we have identified an Arabidopsis thaliana nucleotide sugar transporter that is able to complement the CMP-sialic acid transport deficiency of Lec2 cells.	N-Acetylneuraminic Acid	133-144	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	169-173
18279844-0	2008	CD33-related sialic-acid-binding immunoglobulin-like lectins in health and disease.	N-Acetylneuraminic Acid	13-24	CD33 molecule	Homo sapiens	0-4
18508118-3	2008	More specifically, it is thought that Abeta interacts with ganglioside rich and sialic acid rich regions of cell surfaces.	N-Acetylneuraminic Acid	80-91	amyloid beta precursor protein	Homo sapiens	38-43
18628673-0	2008	The key enzyme of sialic acid biosynthesis (GNE) promotes neurite outgrowth of PC12 cells.	N-Acetylneuraminic Acid	18-29	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	44-47
18628673-3	2008	In our study, we showed that nerve growth factor-induced neurite outgrowth of PC12-cells enhances the expression of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE), the key enzyme for the biosynthesis of sialic acid.	N-Acetylneuraminic Acid	225-236	nerve growth factor	Rattus norvegicus	29-48
18628673-3	2008	In our study, we showed that nerve growth factor-induced neurite outgrowth of PC12-cells enhances the expression of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE), the key enzyme for the biosynthesis of sialic acid.	N-Acetylneuraminic Acid	225-236	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	116-178
18628673-3	2008	In our study, we showed that nerve growth factor-induced neurite outgrowth of PC12-cells enhances the expression of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE), the key enzyme for the biosynthesis of sialic acid.	N-Acetylneuraminic Acid	225-236	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	180-183
18508118-4	2008	In light of such evidence, we have hypothesized that the Abeta-membrane sialic acid interaction could be inhibited through use of a biomimic multivalent sialic acid compound that would compete with the cell surface for Abeta binding.	N-Acetylneuraminic Acid	72-83	amyloid beta precursor protein	Homo sapiens	57-62
18508118-4	2008	In light of such evidence, we have hypothesized that the Abeta-membrane sialic acid interaction could be inhibited through use of a biomimic multivalent sialic acid compound that would compete with the cell surface for Abeta binding.	N-Acetylneuraminic Acid	72-83	amyloid beta precursor protein	Homo sapiens	219-224
18508118-4	2008	In light of such evidence, we have hypothesized that the Abeta-membrane sialic acid interaction could be inhibited through use of a biomimic multivalent sialic acid compound that would compete with the cell surface for Abeta binding.	N-Acetylneuraminic Acid	153-164	amyloid beta precursor protein	Homo sapiens	57-62
18508118-4	2008	In light of such evidence, we have hypothesized that the Abeta-membrane sialic acid interaction could be inhibited through use of a biomimic multivalent sialic acid compound that would compete with the cell surface for Abeta binding.	N-Acetylneuraminic Acid	153-164	amyloid beta precursor protein	Homo sapiens	219-224
18606703-11	2008	Finally, an EG construct supported slow rolling of E- and P-selectin bearing cells in a sialic acid and fucose dependent manner, and the introduction of intact EG into a B cell line facilitated rolling interactions on a P-selectin substratum.	N-Acetylneuraminic Acid	88-99	podocalyxin like 2	Homo sapiens	12-14
18456648-8	2008	Mucin/LL-37 binding was partially prevented by treatment of mucin with neuraminidase, indicating involvement of sialic acid moieties.	N-Acetylneuraminic Acid	112-123	LOC100508689	Homo sapiens	0-5
18456648-8	2008	Mucin/LL-37 binding was partially prevented by treatment of mucin with neuraminidase, indicating involvement of sialic acid moieties.	N-Acetylneuraminic Acid	112-123	cathelicidin antimicrobial peptide	Homo sapiens	6-11
18456648-8	2008	Mucin/LL-37 binding was partially prevented by treatment of mucin with neuraminidase, indicating involvement of sialic acid moieties.	N-Acetylneuraminic Acid	112-123	LOC100508689	Homo sapiens	60-65
18456648-8	2008	Mucin/LL-37 binding was partially prevented by treatment of mucin with neuraminidase, indicating involvement of sialic acid moieties.	N-Acetylneuraminic Acid	112-123	neuraminidase 1	Homo sapiens	71-84
18495144-9	2008	As a result attractive interactions between oppositely charged moieties of sialic acid residues from mucin and amine groups from chitosan residing on the opposing surfaces contribute to the increased friction.	N-Acetylneuraminic Acid	75-86	LOC100508689	Homo sapiens	101-106
18452900-0	2008	C-5 modifications in N-acetyl-neuraminic acid: scope and limitations.	N-Acetylneuraminic Acid	21-45	complement C5	Homo sapiens	0-3
18452900-4	2008	This review summarizes the latest developments in the synthesis of C-5 modified sialic acid glycosyl donors and glycosyl acceptors and their application in the synthesis of alpha-sialosides.	N-Acetylneuraminic Acid	80-91	complement C5	Homo sapiens	67-70
18606998-0	2008	Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1.	N-Acetylneuraminic Acid	11-22	klotho	Homo sapiens	33-39
18606998-0	2008	Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1.	N-Acetylneuraminic Acid	11-22	transient receptor potential cation channel subfamily V member 5	Homo sapiens	73-78
18606998-0	2008	Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1.	N-Acetylneuraminic Acid	11-22	galectin 1	Homo sapiens	102-112
18633759-0	2008	Association between protein bound sialic acid and high sensitivity C-reactive protein in prehypertension: a possible indication of underlying cardiovascular risk.	N-Acetylneuraminic Acid	34-45	C-reactive protein	Homo sapiens	67-85
18633759-9	2008	Correlation analysis revealed a significant association between the protein bound sialic acid with hsCRP, LDL cholesterol, and LDL-C/Apo-B.	N-Acetylneuraminic Acid	82-93	apolipoprotein B	Homo sapiens	133-138
19787087-7	2008	We hypothesize that replacing the mutated GNE gene with the wildtype gene may restore functional capacity of GNE/MNK and therefore production of sialic acid, allowing for improvement in muscle function and/or delay in rate of muscle deterioration.	N-Acetylneuraminic Acid	145-156	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	42-45
19024534-8	2008	The contents of sialic acid and carnitine in the epididymis were significantly negatively correlated with the HIF-1alpha expression (r = -0.649, P = 0.017; r = -0.666, P = 0.013).	N-Acetylneuraminic Acid	16-27	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	110-120
19787087-9	2008	GNE/MNK enzyme function was significantly increased and subsequent induction of sialic acid production was demonstrated after transfection into Lec3 cells with the wild type or R266Q mutant GNE vector.	N-Acetylneuraminic Acid	80-91	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	190-193
18560563-1	2008	BACKGROUND: Hereditary inclusion body myopathy (HIBM) is a rare neuromuscular disorder caused by mutations in GNE, the key enzyme in the biosynthetic pathway of sialic acid.	N-Acetylneuraminic Acid	161-172	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	110-113
18505252-1	2008	CD22 is a B cell-specific sialic acid-binding immunoglobulin-like lectin (Siglec) whose function as a regulator of B cell signaling is modulated by its interaction with glycan ligands bearing the sequence NeuAc alpha2-6Gal.	N-Acetylneuraminic Acid	26-37	CD22 molecule	Homo sapiens	0-4
18505252-1	2008	CD22 is a B cell-specific sialic acid-binding immunoglobulin-like lectin (Siglec) whose function as a regulator of B cell signaling is modulated by its interaction with glycan ligands bearing the sequence NeuAc alpha2-6Gal.	N-Acetylneuraminic Acid	205-210	CD22 molecule	Homo sapiens	0-4
18456258-8	2008	The proadhesive effects of PODXL were absent in sialic acid deficient O-glycomutant CHO cells.	N-Acetylneuraminic Acid	48-59	podocalyxin	Cricetulus griseus	27-32
18402602-6	2008	The degradation of terminal saccharide moieties on the MUC5B was demonstrated by a marked decrease in both sialic acid and fucose reactivity.	N-Acetylneuraminic Acid	107-118	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	55-60
18519646-12	2008	In addition, binding of alpha2,3-linked sialic acid-specific Maackia amurensis lectin II to purified CXCR2 from neuraminidase-treated CXCR2-transfected HEK293 cells was markedly impaired.	N-Acetylneuraminic Acid	40-51	C-X-C motif chemokine receptor 2	Homo sapiens	101-106
18519646-12	2008	In addition, binding of alpha2,3-linked sialic acid-specific Maackia amurensis lectin II to purified CXCR2 from neuraminidase-treated CXCR2-transfected HEK293 cells was markedly impaired.	N-Acetylneuraminic Acid	40-51	C-X-C motif chemokine receptor 2	Homo sapiens	134-139
18332077-7	2008	Interestingly, two core 1 type glycans were identified that had sialic acid alpha2-8 linked to sialylated core 1 type structures (9% of the total glycan pool).	N-Acetylneuraminic Acid	64-75	immunoglobulin binding protein 1	Homo sapiens	76-84
18414664-5	2008	Using a stringent binding assay, sialoadhesin-expressing monocytes adsorbed HIV-1 through interaction with the sialic acid residues on the viral envelope glycoprotein gp120.	N-Acetylneuraminic Acid	111-122	sialic acid binding Ig like lectin 1	Homo sapiens	33-45
18083324-7	2008	These results suggest that fibrinogen and fibronectin facilitate the adherence of conidia to A549 cells probably through the interaction with adhesin-type molecules or a sialic acid based recognition system.	N-Acetylneuraminic Acid	170-181	fibrinogen beta chain	Homo sapiens	27-37
18083324-7	2008	These results suggest that fibrinogen and fibronectin facilitate the adherence of conidia to A549 cells probably through the interaction with adhesin-type molecules or a sialic acid based recognition system.	N-Acetylneuraminic Acid	170-181	fibronectin 1	Homo sapiens	42-53
18043943-8	2008	Thus, ShB gating is modulated by two complementary but distinct sugar-dependent mechanisms, (1) an N-linked sialic acid-dependent surface charge effect and (2) a sialic acid-independent effect that is consistent with N-linked sugars affecting the stability of ShB among its functional states.	N-Acetylneuraminic Acid	108-119	shb	Drosophila melanogaster	6-9
18414664-5	2008	Using a stringent binding assay, sialoadhesin-expressing monocytes adsorbed HIV-1 through interaction with the sialic acid residues on the viral envelope glycoprotein gp120.	N-Acetylneuraminic Acid	111-122	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	167-172
18080182-10	2008	We also observed that removing surface sialic acid of immature mo-DC by neuraminidase significantly decreased its endocytic capacity, while it increased in monocytes.	N-Acetylneuraminic Acid	39-50	neuraminidase 1	Homo sapiens	72-85
18255354-3	2008	The only protein in the ACS family to which a human disease has been linked, is sialin, the proton-driven lysosomal carrier for sialic acid.	N-Acetylneuraminic Acid	128-139	solute carrier family 17 member 5	Homo sapiens	80-86
18228138-9	2008	Surprisingly, after application of both sialic acid precursors the phosphorylation and translocation of erk1/2 into the nucleus are activated, thus influencing the expression of genes involved in the differentiation of cells, such as the transcription factor c-Jun or TOAD-64/Ulip/CRMP (Turned ON After Division, 64 kd/ unc-33-like phosphoprotein/Collapsin Response Mediator Protein).	N-Acetylneuraminic Acid	40-51	mitogen activated protein kinase 3	Rattus norvegicus	104-110
18263654-10	2008	We obtained evidence that glucuronic acid as well as sialic acid inhibited this interaction, suggesting that the nonsulfated HNK-1 epitope on laminin-1 may regulate its binding and play a role in maintenance of the proper structure in the kidney basal lamina.	N-Acetylneuraminic Acid	53-64	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	125-130
18228138-9	2008	Surprisingly, after application of both sialic acid precursors the phosphorylation and translocation of erk1/2 into the nucleus are activated, thus influencing the expression of genes involved in the differentiation of cells, such as the transcription factor c-Jun or TOAD-64/Ulip/CRMP (Turned ON After Division, 64 kd/ unc-33-like phosphoprotein/Collapsin Response Mediator Protein).	N-Acetylneuraminic Acid	40-51	dihydropyrimidinase-like 2	Rattus norvegicus	268-275
18022638-2	2008	To investigate the molecular mechanism underlying sialic acid Ig-like lectin (Siglec) functions, we determined the crystal structure of the two N-terminal extracellular domains of human myeloid cell inhibitory receptor Siglec-5 (CD170) and its complexes with two sialylated carbohydrates.	N-Acetylneuraminic Acid	50-61	sialic acid binding Ig like lectin 5	Homo sapiens	219-227
18067554-2	2008	Like other coreceptors, the ability of CD22 to modulate B-cell signalling is critically dependent upon its proximity to the BCR, and this in turn is governed by the binding of its extracellular domain to alpha2,6-linked sialic acid ligands.	N-Acetylneuraminic Acid	220-231	CD22 molecule	Homo sapiens	39-43
18288410-7	2008	In conclusion, our results indicate that galectin-3-induced apoptosis is regulated by cell surface expression of N-glycans and sialic acid in human diffuse large B cell lymphoma.	N-Acetylneuraminic Acid	127-138	galectin 3	Homo sapiens	41-51
17803693-12	2008	A significant correlation was found between CAV-1 mRNA expression levels in VAT and different circulating inflammatory markers such as sialic acid (SA) (P &lt; 0.001) and fibrinogen (P &lt; 0.001) as well as with MCP1 mRNA expression (P &lt; 0.05).	N-Acetylneuraminic Acid	135-146	caveolin 1	Homo sapiens	44-49
17803693-12	2008	A significant correlation was found between CAV-1 mRNA expression levels in VAT and different circulating inflammatory markers such as sialic acid (SA) (P &lt; 0.001) and fibrinogen (P &lt; 0.001) as well as with MCP1 mRNA expression (P &lt; 0.05).	N-Acetylneuraminic Acid	148-150	caveolin 1	Homo sapiens	44-49
18036650-0	2008	Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement.	N-Acetylneuraminic Acid	95-106	Fc epsilon receptor Ia	Homo sapiens	14-25
18036650-1	2008	BACKGROUND: Sialic acid-binding immunoglobulin-like lectins (Siglecs) are a family of glycan-binding inhibitory receptors, and among them, Siglec-8 is selectively expressed on human eosinophils, basophils, and mast cells.	N-Acetylneuraminic Acid	12-23	sialic acid binding Ig like lectin 8	Homo sapiens	139-147
18172551-3	2008	Biosynthesis of these glycans occurs in a stepwise fashion beginning with the addition of N-acetylgalactosamine by the enzyme N-acetylgalactosaminyltransferase 2 and continuing with the addition of either galactose by beta1,3-galactosyltransferase or a terminal sialic acid by a N-acetylgalactosamine-specific alpha2,6-sialyltransferase.	N-Acetylneuraminic Acid	262-273	chondroitin polymerizing factor	Homo sapiens	126-161
18309288-5	2008	Human erythropoietin expressed in T. ni cells (rhEPO) was subjected to in vitro glycosylation by using recombinant glycosyltransferases and was converted into complex-type glycan with terminal sialic acid.	N-Acetylneuraminic Acid	193-204	erythropoietin	Homo sapiens	6-20
18006263-3	2008	These results provide strong evidence that the sialic acid residue in TF masks its binding ability to serum proteins.	N-Acetylneuraminic Acid	47-58	transferrin	Homo sapiens	70-72
18310617-0	2008	Differential influence of the tumour-specific non-human sialic acid containing GM3 ganglioside on CD4+CD25- effector and naturally occurring CD4+CD25+ regulatory T cells function.	N-Acetylneuraminic Acid	56-67	CD4 molecule	Homo sapiens	98-101
18310617-0	2008	Differential influence of the tumour-specific non-human sialic acid containing GM3 ganglioside on CD4+CD25- effector and naturally occurring CD4+CD25+ regulatory T cells function.	N-Acetylneuraminic Acid	56-67	interleukin 2 receptor subunit alpha	Homo sapiens	102-106
18425435-6	2008	After surveying the current state of knowledge in this field, the review focuses on the sialic acid transporter sialin and shows how recent functional data using the above whole-cell approach shed new light on the pathogenesis of sialic acid storage disorders by revealing the existence of a residual transport activity associated with Salla disease.	N-Acetylneuraminic Acid	88-99	solute carrier family 17 member 5	Homo sapiens	112-118
18023277-0	2008	Sialic acid moiety of apolipoprotein E3 at Thr(194) affects its interaction with beta-amyloid(1-42) peptides.	N-Acetylneuraminic Acid	0-11	apolipoprotein E	Homo sapiens	22-39
18023277-3	2008	We investigated the effects of a sialic acid moiety of apoE on the apoE-Abeta interaction.	N-Acetylneuraminic Acid	33-44	apolipoprotein E	Homo sapiens	55-59
18023277-3	2008	We investigated the effects of a sialic acid moiety of apoE on the apoE-Abeta interaction.	N-Acetylneuraminic Acid	33-44	apolipoprotein E	Homo sapiens	67-71
18023277-3	2008	We investigated the effects of a sialic acid moiety of apoE on the apoE-Abeta interaction.	N-Acetylneuraminic Acid	33-44	amyloid beta precursor protein	Homo sapiens	72-77
18023277-9	2008	CONCLUSIONS: We suggest that AD development is controlled not only by the apoE isoforms but also by the posttranslational modifications in apoE, such as those in the sialic acid moieties, which are abundant in apoE derived from the brain.	N-Acetylneuraminic Acid	166-177	apolipoprotein E	Homo sapiens	139-143
18023277-9	2008	CONCLUSIONS: We suggest that AD development is controlled not only by the apoE isoforms but also by the posttranslational modifications in apoE, such as those in the sialic acid moieties, which are abundant in apoE derived from the brain.	N-Acetylneuraminic Acid	166-177	apolipoprotein E	Homo sapiens	139-143
18022638-2	2008	To investigate the molecular mechanism underlying sialic acid Ig-like lectin (Siglec) functions, we determined the crystal structure of the two N-terminal extracellular domains of human myeloid cell inhibitory receptor Siglec-5 (CD170) and its complexes with two sialylated carbohydrates.	N-Acetylneuraminic Acid	50-61	sialic acid binding Ig like lectin 5	Homo sapiens	229-234
17996251-4	2007	SSL5 is shown here to bind to human granulocytes and to the cell surface receptors for human IgA (Fc alphaRI) and P-selectin [P-selectin glycoprotein ligand-1 (PSGL-1)] in a sialic acid (Sia)-dependent manner.	N-Acetylneuraminic Acid	174-185	selectin P	Homo sapiens	114-124
17986444-1	2008	Polysialic acid (polySia), an alpha2,8-linked polymer of N-acetylneuraminic acid, represents an essential regulator of neural cell adhesion molecule (NCAM) functions.	N-Acetylneuraminic Acid	57-80	neural cell adhesion molecule 1	Mus musculus	119-148
17986444-1	2008	Polysialic acid (polySia), an alpha2,8-linked polymer of N-acetylneuraminic acid, represents an essential regulator of neural cell adhesion molecule (NCAM) functions.	N-Acetylneuraminic Acid	57-80	neural cell adhesion molecule 1	Mus musculus	150-154
17938215-0	2008	L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway.	N-Acetylneuraminic Acid	117-140	ficolin 2	Homo sapiens	0-9
18173730-0	2008	An exposed carboxyl group on sialic acid is essential for gangliosides to inhibit calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase: relevance to gangliosidoses.	N-Acetylneuraminic Acid	29-40	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	105-144
18173730-2	2008	We now systematically examine the effect of various gangliosides and their analogs on Ca2+-uptake via SERCA and demonstrate that an exposed carboxyl group on the ganglioside sialic acid residue is required for inhibition.	N-Acetylneuraminic Acid	174-185	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	102-107
17938215-0	2008	L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway.	N-Acetylneuraminic Acid	117-140	mannose binding lectin 2	Homo sapiens	10-32
17938215-9	2008	When N-acetylneuraminic acid (NeuNAc) was selectively removed from GBS cells by treatment with neuraminidase, the reduction in L-ficolin binding was correlated with the amount of NeuNAc removed.	N-Acetylneuraminic Acid	5-28	neuraminidase 1	Homo sapiens	95-108
17938215-9	2008	When N-acetylneuraminic acid (NeuNAc) was selectively removed from GBS cells by treatment with neuraminidase, the reduction in L-ficolin binding was correlated with the amount of NeuNAc removed.	N-Acetylneuraminic Acid	5-28	ficolin 2	Homo sapiens	127-136
17938215-9	2008	When N-acetylneuraminic acid (NeuNAc) was selectively removed from GBS cells by treatment with neuraminidase, the reduction in L-ficolin binding was correlated with the amount of NeuNAc removed.	N-Acetylneuraminic Acid	30-36	neuraminidase 1	Homo sapiens	95-108
17938215-9	2008	When N-acetylneuraminic acid (NeuNAc) was selectively removed from GBS cells by treatment with neuraminidase, the reduction in L-ficolin binding was correlated with the amount of NeuNAc removed.	N-Acetylneuraminic Acid	30-36	ficolin 2	Homo sapiens	127-136
17938215-9	2008	When N-acetylneuraminic acid (NeuNAc) was selectively removed from GBS cells by treatment with neuraminidase, the reduction in L-ficolin binding was correlated with the amount of NeuNAc removed.	N-Acetylneuraminic Acid	179-185	neuraminidase 1	Homo sapiens	95-108
17938215-9	2008	When N-acetylneuraminic acid (NeuNAc) was selectively removed from GBS cells by treatment with neuraminidase, the reduction in L-ficolin binding was correlated with the amount of NeuNAc removed.	N-Acetylneuraminic Acid	179-185	ficolin 2	Homo sapiens	127-136
17938215-10	2008	Additionally, L-ficolin was able to bind to wild-type strains but was able to bind only weakly to unencapsulated mutants and a mutant strain in which the CPS lacks NeuNAc.	N-Acetylneuraminic Acid	164-170	ficolin 2	Homo sapiens	14-23
17947393-1	2008	The leukocyte CD33-related sialic acid-binding Ig-like lectins (Siglecs) are implicated in glycan recognition and host defense against and pathogenicity of sialylated pathogens.	N-Acetylneuraminic Acid	27-38	CD33 molecule	Homo sapiens	14-18
17852805-5	2008	Total serum sialic acid and sialic acid index of Apolipoprotein J have the potential to be included in a combination of measurements providing an accurate, more exact, assessment of alcohol consumption in a variety of clinical and research settings.	N-Acetylneuraminic Acid	28-39	clusterin	Homo sapiens	49-65
18056365-9	2007	Interestingly, the binding of the LacNAc-specific lectins galectin-3 and -8 increased during maturation and up-regulation of sialic acid expression by mDC correlated with an increased binding of siglec-1, -2, and -7.	N-Acetylneuraminic Acid	125-136	chemokine (C-C motif) ligand 22	Mus musculus	151-154
18056365-9	2007	Interestingly, the binding of the LacNAc-specific lectins galectin-3 and -8 increased during maturation and up-regulation of sialic acid expression by mDC correlated with an increased binding of siglec-1, -2, and -7.	N-Acetylneuraminic Acid	125-136	sialic acid binding Ig like lectin 1	Homo sapiens	195-215
17996251-4	2007	SSL5 is shown here to bind to human granulocytes and to the cell surface receptors for human IgA (Fc alphaRI) and P-selectin [P-selectin glycoprotein ligand-1 (PSGL-1)] in a sialic acid (Sia)-dependent manner.	N-Acetylneuraminic Acid	174-185	selectin P ligand	Homo sapiens	126-158
17996251-4	2007	SSL5 is shown here to bind to human granulocytes and to the cell surface receptors for human IgA (Fc alphaRI) and P-selectin [P-selectin glycoprotein ligand-1 (PSGL-1)] in a sialic acid (Sia)-dependent manner.	N-Acetylneuraminic Acid	174-185	selectin P ligand	Homo sapiens	160-166
17932038-6	2007	Furthermore, circulatory profiles of high number and low number PEG-AChEs differing in their sialic acid contents demonstrate a direct relationship between PEG loading and the effective seclusion of AChE from the hepatic asialoglycoprotein receptor clearance system.	N-Acetylneuraminic Acid	93-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
17996251-4	2007	SSL5 is shown here to bind to human granulocytes and to the cell surface receptors for human IgA (Fc alphaRI) and P-selectin [P-selectin glycoprotein ligand-1 (PSGL-1)] in a sialic acid (Sia)-dependent manner.	N-Acetylneuraminic Acid	187-190	selectin P	Homo sapiens	114-124
17996251-4	2007	SSL5 is shown here to bind to human granulocytes and to the cell surface receptors for human IgA (Fc alphaRI) and P-selectin [P-selectin glycoprotein ligand-1 (PSGL-1)] in a sialic acid (Sia)-dependent manner.	N-Acetylneuraminic Acid	187-190	selectin P ligand	Homo sapiens	160-166
17933575-1	2007	Two disease-associated missense mutations in the sialin gene (G328E and G409E) have recently been identified in patients with lysosomal free sialic acid storage disease.	N-Acetylneuraminic Acid	141-152	solute carrier family 17 member 5	Homo sapiens	49-55
18646567-2	2007	Distal myopathy with rimmed vacuoles (DMRV) or hereditary inclusion body myopathy (hIBM) is an adult onset slowly progressive myopathy secondary to mutations in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene that encodes a bifunctional enzyme which catalyzes the rate-limiting step in sialic acid biosynthesis.	N-Acetylneuraminic Acid	316-327	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	165-227
17979238-3	2007	"Orthana" mucin has short side-chains, low levels of sialic acid residues, and includes minute amounts of cystine residues that can be responsible for the self-polymerization of mucin.	N-Acetylneuraminic Acid	53-64	LOC100508689	Homo sapiens	10-15
17913589-6	2007	Alpha 2, 6 sialic acid (SA) of serum IgA1 was measured by sandwich-ELISA.	N-Acetylneuraminic Acid	24-26	immunoglobulin heavy constant alpha 1	Homo sapiens	37-41
17913589-8	2007	Alpha 2, 6 SA level in patients with IgAN was lower than that in healthy controls (0.92+/-0.14 vs. 0.98+/-0.12, P=0.001) and non-IgAN glomerulonephritis (0.92+/-0.14 vs. 1.00+/-0.18, n=53, P=0.001).	N-Acetylneuraminic Acid	11-13	IGAN1	Homo sapiens	37-41
17913589-12	2007	Although patients in Low SA Group had worse renal function evaluated by eGFR, there was no significant difference in various CKD stages in non-IgAN renal function controls (n=42, P=0.352).	N-Acetylneuraminic Acid	25-27	epidermal growth factor receptor	Homo sapiens	72-76
17704511-1	2007	Distal myopathy with rimmed vacuoles (DMRV) or hereditary inclusion body myopathy (hIBM) is an early adult-onset distal myopathy caused by mutations in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene which encodes for a bifunctional enzyme involved in sialic acid biosynthesis.	N-Acetylneuraminic Acid	282-293	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	156-218
17913261-0	2007	Expression of the human CMP-NeuAc:GM3 alpha2,8-sialyltransferase (GD3 synthase) gene through the NF-kappaB activation in human melanoma SK-MEL-2 cells.	N-Acetylneuraminic Acid	28-33	GRDX	Homo sapiens	66-69
17913261-0	2007	Expression of the human CMP-NeuAc:GM3 alpha2,8-sialyltransferase (GD3 synthase) gene through the NF-kappaB activation in human melanoma SK-MEL-2 cells.	N-Acetylneuraminic Acid	28-33	nuclear factor kappa B subunit 1	Homo sapiens	97-106
17597592-0	2007	Synthesis of C-4 and C-7 triazole analogs of zanamivir as multivalent sialic acid containing scaffolds.	N-Acetylneuraminic Acid	70-81	complement C4A (Rodgers blood group)	Homo sapiens	13-16
18046671-11	2007	With regards to the individual residues, we found that IgAN sera contained less sugar and galactose and sialic acid moieties than sera from control subjects, was reduced in IgAN sera, while terminal N-acetylgalactosamine levels were higher when compared with normal serum.	N-Acetylneuraminic Acid	104-115	IGAN1	Homo sapiens	55-59
17480010-2	2007	Increasing evidence has implicated that aberrant glycosylation of IgA1 molecules, including alpha2,6 sialic acid defects, are involved in the pathogenesis of IgAN.	N-Acetylneuraminic Acid	101-112	immunoglobulin heavy constant alpha 1	Homo sapiens	66-70
17480010-2	2007	Increasing evidence has implicated that aberrant glycosylation of IgA1 molecules, including alpha2,6 sialic acid defects, are involved in the pathogenesis of IgAN.	N-Acetylneuraminic Acid	101-112	IGAN1	Homo sapiens	158-162
17480010-8	2007	The alpha2,6 sialic acid contents of serum IgA1 in 497 patients were analyzed.	N-Acetylneuraminic Acid	13-24	immunoglobulin heavy constant alpha 1	Homo sapiens	43-47
17480010-10	2007	Furthermore, the ADG haplotype was associated with the deficient degrees of alpha2,6 sialic acid of IgA1 molecules in IgAN patients (r=0.408, p=0.0035).	N-Acetylneuraminic Acid	85-96	immunoglobulin heavy constant alpha 1	Homo sapiens	100-104
17480010-10	2007	Furthermore, the ADG haplotype was associated with the deficient degrees of alpha2,6 sialic acid of IgA1 molecules in IgAN patients (r=0.408, p=0.0035).	N-Acetylneuraminic Acid	85-96	IGAN1	Homo sapiens	118-122
17673919-2	2007	GNE encodes a bi-functional enzyme acting in the biosynthetic pathway of sialic acid.	N-Acetylneuraminic Acid	73-84	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
17722062-1	2007	The novel myelin-associated glycoprotein (MAG) inhibitor BENZ binds to the N-acetylneuraminic acid (Neu5Ac) portion of the N-terminal Ig-like domain of MAG.	N-Acetylneuraminic Acid	75-98	myelin-associated glycoprotein	Rattus norvegicus	10-40
17722062-1	2007	The novel myelin-associated glycoprotein (MAG) inhibitor BENZ binds to the N-acetylneuraminic acid (Neu5Ac) portion of the N-terminal Ig-like domain of MAG.	N-Acetylneuraminic Acid	75-98	myelin-associated glycoprotein	Rattus norvegicus	42-45
17722062-1	2007	The novel myelin-associated glycoprotein (MAG) inhibitor BENZ binds to the N-acetylneuraminic acid (Neu5Ac) portion of the N-terminal Ig-like domain of MAG.	N-Acetylneuraminic Acid	75-98	myelin-associated glycoprotein	Rattus norvegicus	152-155
17722062-1	2007	The novel myelin-associated glycoprotein (MAG) inhibitor BENZ binds to the N-acetylneuraminic acid (Neu5Ac) portion of the N-terminal Ig-like domain of MAG.	N-Acetylneuraminic Acid	100-106	myelin-associated glycoprotein	Rattus norvegicus	10-40
17722062-1	2007	The novel myelin-associated glycoprotein (MAG) inhibitor BENZ binds to the N-acetylneuraminic acid (Neu5Ac) portion of the N-terminal Ig-like domain of MAG.	N-Acetylneuraminic Acid	100-106	myelin-associated glycoprotein	Rattus norvegicus	42-45
17722062-1	2007	The novel myelin-associated glycoprotein (MAG) inhibitor BENZ binds to the N-acetylneuraminic acid (Neu5Ac) portion of the N-terminal Ig-like domain of MAG.	N-Acetylneuraminic Acid	100-106	myelin-associated glycoprotein	Rattus norvegicus	152-155
17699578-4	2007	To determine the amino acids important for BKV binding to the sialic acid portion of the complex, we generated a series of 17 point mutations in VP1 and scored them for viral growth.	N-Acetylneuraminic Acid	62-73	VP1	Human polyomavirus 1	145-148
17699578-12	2007	We next mapped these mutations onto a model of BKV VP1 to provide atomic insight into the role of these sites in the binding of sialic acid to VP1.	N-Acetylneuraminic Acid	128-139	VP1	Human polyomavirus 1	51-54
17699578-12	2007	We next mapped these mutations onto a model of BKV VP1 to provide atomic insight into the role of these sites in the binding of sialic acid to VP1.	N-Acetylneuraminic Acid	128-139	VP1	Human polyomavirus 1	143-146
17912239-7	2007	Benzyl-alpha-GalNAc (O-glycosylation inhibitor) was used to reduce mucin on cell surfaces, and neuraminidase was used to hydrolyse sialic acid at the distal end of carbohydrate chains.	N-Acetylneuraminic Acid	131-142	neuraminidase 1	Homo sapiens	95-108
17851894-9	2007	Likewise, neuraminidase digestion of peripheral sialic acid revealed similar concentration of the penultimate galactose residue.	N-Acetylneuraminic Acid	48-59	neuraminidase 1	Homo sapiens	10-23
17623676-1	2007	Polysialic acid (PSA) is a polymer of N-acetylneuraminic acid residues added post-translationally to the membrane-bound neural cell adhesion molecule (NCAM).	N-Acetylneuraminic Acid	38-61	neural cell adhesion molecule 1	Homo sapiens	120-149
17623676-1	2007	Polysialic acid (PSA) is a polymer of N-acetylneuraminic acid residues added post-translationally to the membrane-bound neural cell adhesion molecule (NCAM).	N-Acetylneuraminic Acid	38-61	neural cell adhesion molecule 1	Homo sapiens	151-155
17706199-2	2007	The key enzyme for the biosynthesis of sialic acid is the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE).	N-Acetylneuraminic Acid	39-50	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	Cricetulus griseus	58-120
17706199-2	2007	The key enzyme for the biosynthesis of sialic acid is the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE).	N-Acetylneuraminic Acid	39-50	bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase	Cricetulus griseus	122-125
17706199-3	2007	Mutations in the binding site of the feedback inhibitor CMP-sialic acid of the GNE leads to sialuria, a disease in which patients produce sialic acid in gram scale.	N-Acetylneuraminic Acid	60-71	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	79-82
17706199-3	2007	Mutations in the binding site of the feedback inhibitor CMP-sialic acid of the GNE leads to sialuria, a disease in which patients produce sialic acid in gram scale.	N-Acetylneuraminic Acid	138-149	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	79-82
17716661-2	2007	In this study we demonstrate that two populations of GdA with subtle differences in their net ionic charge are present in the amniotic fluid and that, apoptotic activity is exhibited only by the population with more sialic acid residues.	N-Acetylneuraminic Acid	216-227	progestagen associated endometrial protein	Homo sapiens	53-56
17716661-3	2007	Significantly, removal of sialic acid residues from the active populations of GdA abrogates the activity of the molecule, suggesting that the extent of sialylation might be a factor regulating the activity of GdA.	N-Acetylneuraminic Acid	26-37	progestagen associated endometrial protein	Homo sapiens	78-81
17716661-3	2007	Significantly, removal of sialic acid residues from the active populations of GdA abrogates the activity of the molecule, suggesting that the extent of sialylation might be a factor regulating the activity of GdA.	N-Acetylneuraminic Acid	26-37	progestagen associated endometrial protein	Homo sapiens	209-212
17597592-0	2007	Synthesis of C-4 and C-7 triazole analogs of zanamivir as multivalent sialic acid containing scaffolds.	N-Acetylneuraminic Acid	70-81	complement C7	Homo sapiens	21-24
17715351-0	2007	The inhibition site on myelin-associated glycoprotein is within Ig-domain 5 and is distinct from the sialic acid binding site.	N-Acetylneuraminic Acid	101-112	LOC103161439	Cricetulus griseus	23-53
17649979-4	2007	Sialic acid caps the glycan chains of alpha-dystroglycan and occurs as a posttranslational modification on the muscle-specific kinase component of the agrin receptor.	N-Acetylneuraminic Acid	0-11	agrin	Homo sapiens	151-156
17649979-5	2007	We found that agrin-G3 binds sialic acid in a Ca2+-dependent manner.	N-Acetylneuraminic Acid	29-40	agrin	Homo sapiens	14-19
17497959-6	2007	Removal of sialic acid on sLe(X)-PrP(C)-Ig enables the fusion protein to bind all selectins.	N-Acetylneuraminic Acid	11-22	prion protein	Homo sapiens	33-39
17497959-10	2007	Therefore the presence of sialic acid prevents the binding of PrP(C) in human brain to selectins.	N-Acetylneuraminic Acid	26-37	prion protein	Homo sapiens	62-68
17567703-0	2007	Porcine arterivirus attachment to the macrophage-specific receptor sialoadhesin is dependent on the sialic acid-binding activity of the N-terminal immunoglobulin domain of sialoadhesin.	N-Acetylneuraminic Acid	100-111	sialic acid binding Ig like lectin 1	Homo sapiens	67-79
17567703-0	2007	Porcine arterivirus attachment to the macrophage-specific receptor sialoadhesin is dependent on the sialic acid-binding activity of the N-terminal immunoglobulin domain of sialoadhesin.	N-Acetylneuraminic Acid	100-111	sialic acid binding Ig like lectin 1	Homo sapiens	172-184
17567703-1	2007	The sialic acid-binding lectin sialoadhesin (Sn) is a macrophage-restricted receptor for porcine reproductive and respiratory syndrome virus (PRRSV).	N-Acetylneuraminic Acid	4-15	sialic acid binding Ig like lectin 1	Homo sapiens	31-43
17697868-4	2007	The plasma carbohydrate-deficient transferrin (CDT) and sialic acid index of plasma apolipoprotein J were also altered in the alcoholic group compared with the nondrinkers.	N-Acetylneuraminic Acid	56-67	clusterin	Homo sapiens	84-100
17767167-4	2007	Biochemical analysis of DR5 identified several ectodomain O-(N-acetyl galactosamine-galactose-sialic acid) structures.	N-Acetylneuraminic Acid	94-105	TNF receptor superfamily member 10b	Homo sapiens	24-27
17715351-3	2007	Previously, we showed that the sialic acid binding site on MAG maps to arginine 118 in Ig domain 1 (Kelm et al., 1994).	N-Acetylneuraminic Acid	31-42	LOC103161439	Cricetulus griseus	59-62
17715351-6	2007	We show that when a truncated form of MAG missing Ig domains 1 and 2 is expressed by Chinese hamster ovary (CHO) cells, it does not bind sialic acid, but still inhibits neurite outgrowth almost as effectively as full-length MAG.	N-Acetylneuraminic Acid	137-148	LOC103161439	Cricetulus griseus	38-41
17715351-8	2007	The MAG-Sn molecules were expressed in CHO cells and all contained five Ig domains and were able to bind sialic acid.	N-Acetylneuraminic Acid	105-116	LOC103161439	Cricetulus griseus	4-7
17715351-11	2007	We conclude that the inhibition site on MAG is carried by Ig domain 5 and that this site is distinct from the sialic-acid binding site.	N-Acetylneuraminic Acid	110-121	LOC103161439	Cricetulus griseus	40-43
17604005-2	2007	We and others have shown that Abeta binds with relatively high affinity to clustered sialic acid residues on cell surfaces and that removal of cell surface sialic acids attenuates Abeta toxicity.	N-Acetylneuraminic Acid	85-96	amyloid beta precursor protein	Homo sapiens	30-35
17683546-12	2007	The biological explanation could relate to sialic acid dependent placental membrane differences which vary with ABO blood group.	N-Acetylneuraminic Acid	43-54	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	112-127
17604005-3	2007	We have also shown that sialic acid functionalized dendrimeric polymers can act as mimics of cell surface sialic acid clusters and attenuate Abeta-induced neurotoxicity.	N-Acetylneuraminic Acid	24-35	amyloid beta precursor protein	Homo sapiens	141-146
17507233-0	2007	Synthesis of sialic acid derivatives as ligands for the myelin-associated glycoprotein (MAG).	N-Acetylneuraminic Acid	13-24	myelin associated glycoprotein	Homo sapiens	56-86
17239614-5	2007	In HA-inhibition assays performed with several carbohydrates and glycoproteins, LVL showed a distinct and unique specificity for GalNAc/GluNAc/NeuAc which had an acetyl group, while glycoproteins fetuin and bovine submaxillary mucin (BSM) had sialic acid.	N-Acetylneuraminic Acid	143-148	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	17-18
17507233-0	2007	Synthesis of sialic acid derivatives as ligands for the myelin-associated glycoprotein (MAG).	N-Acetylneuraminic Acid	13-24	myelin associated glycoprotein	Homo sapiens	88-91
17606981-5	2007	However, CD4 T-cell activation also results in increased binding of the CZ-1 antibody that recognizes a sialic acid-containing epitope on CD45RB.	N-Acetylneuraminic Acid	104-115	CD4 molecule	Homo sapiens	9-12
17471014-3	2007	Mutations in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene, which encodes the rate-limiting enzyme in sialic acid biosynthesis, are causative of DMRV/hIBM.	N-Acetylneuraminic Acid	134-145	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	81-84
17293352-10	2007	For the complex-type glycans (partially) (alpha2-6)-sialylated (nearly only N-acetylneuraminic acid) diantennary structures were found; part of the structures were (alpha1-6)-core-fucosylated or (alpha1-3)-fucosylated in the upper antenna (Lewis x).	N-Acetylneuraminic Acid	76-99	immunoglobulin binding protein 1	Homo sapiens	42-50
17606981-3	2007	For example, loss of sialic acid from core 1 O-glycans on T-cell surface glycoproteins CD45, CD43 and CD8, detected with peanut agglutinin (PNA), is a hallmark of immature thymocytes and activated peripheral T cells.	N-Acetylneuraminic Acid	21-32	protein tyrosine phosphatase receptor type C	Homo sapiens	87-91
16919660-3	2007	Differences in the number of the sialic acid moieties in the different rEPO glycoforms confer to these forms different net charges and different bioactivity.	N-Acetylneuraminic Acid	33-44	erythropoietin	Rattus norvegicus	71-75
17553163-9	2007	CONCLUSION: Mutations in type B cats likely disrupt the gene function of CMAH, leading to a predominance of NeuAc.	N-Acetylneuraminic Acid	108-113	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Felis catus	73-77
17585415-4	2007	The thyrotropic potency and thereby the degree of cross reactivity of hCG is determined by several factors, such as content of sialic acid or lack of the C-terminal tail.	N-Acetylneuraminic Acid	127-138	chorionic gonadotropin subunit beta 5	Homo sapiens	70-73
17420276-2	2007	One rare difference is a human-specific inactivating deletion in the CMAH gene, which determines biosynthesis of the sialic acid N-glycolylneuraminic acid (Neu5Gc).	N-Acetylneuraminic Acid	117-128	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	69-73
17549251-2	2007	Mice that harbor mutations in the Gne/Mnk gene produce lower amounts of sialic acid, suffer from hematuria, proteinuria, and structural defects in the glomerulus and die within days after birth.	N-Acetylneuraminic Acid	72-83	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	34-37
17549251-2	2007	Mice that harbor mutations in the Gne/Mnk gene produce lower amounts of sialic acid, suffer from hematuria, proteinuria, and structural defects in the glomerulus and die within days after birth.	N-Acetylneuraminic Acid	72-83	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	38-41
17549255-1	2007	Mutations in the key enzyme of sialic acid biosynthesis, uridine diphospho-N-acetylglucosamine 2-epimerase/N-acetylmannosamine (ManNAc) kinase (GNE/MNK), result in hereditary inclusion body myopathy (HIBM), an adult-onset, progressive neuromuscular disorder.	N-Acetylneuraminic Acid	31-42	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	144-147
17549255-1	2007	Mutations in the key enzyme of sialic acid biosynthesis, uridine diphospho-N-acetylglucosamine 2-epimerase/N-acetylmannosamine (ManNAc) kinase (GNE/MNK), result in hereditary inclusion body myopathy (HIBM), an adult-onset, progressive neuromuscular disorder.	N-Acetylneuraminic Acid	31-42	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	148-151
17374613-8	2007	In fact, three cytosolic glycoproteins, in the range 45-66 kDa, showed a 50-70% decrease of their sialic acid content upon Neu2 expression, supporting their possible role as modulators of the Bcr-Abl complex.	N-Acetylneuraminic Acid	98-109	neuraminidase 2	Homo sapiens	123-127
17272508-1	2007	CD33-related Siglecs (CD33rSiglecs) are a family of sialic acid-recognizing lectins on immune cells whose biologic functions are unknown.	N-Acetylneuraminic Acid	52-63	CD33 antigen	Mus musculus	0-4
17313986-1	2007	The hemagglutinins of influenza viruses isolated from humans typically prefer binding to sialic acid in an alpha2,6 linkage.	N-Acetylneuraminic Acid	89-100	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	107-115
17485090-0	2007	Sialic acid is an essential moiety of mucin as a hydroxyl radical scavenger.	N-Acetylneuraminic Acid	0-11	mucin 1, cell surface associated	Bos taurus	38-43
17485090-1	2007	In this work, we examined the antioxidant role of mucin, a typical sialic acid containing high-molecular weight glycoprotein.	N-Acetylneuraminic Acid	67-78	mucin 1, cell surface associated	Bos taurus	50-55
17485090-5	2007	Our results indicate that BSM has .OH scavenging ability the and sialic acid in mucin is an essential moiety to scavenge .OH.	N-Acetylneuraminic Acid	65-76	mucin 1, cell surface associated	Bos taurus	80-85
17418236-0	2007	Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells.	N-Acetylneuraminic Acid	43-48	immunoglobulin heavy constant alpha 1	Homo sapiens	56-60
17418236-0	2007	Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells.	N-Acetylneuraminic Acid	43-48	immunoglobulin heavy constant alpha 1	Homo sapiens	91-95
17418236-4	2007	Biochemical assays indicated CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase activity in this cell line.	N-Acetylneuraminic Acid	33-38	immunoglobulin heavy constant alpha 1	Homo sapiens	46-50
17418236-7	2007	Expression of the ST6-GalNAcII gene and activity of the CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase were higher in IgA1-producing cell lines from IgAN patients than in such cells from healthy controls.	N-Acetylneuraminic Acid	60-65	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	Homo sapiens	18-30
17418236-7	2007	Expression of the ST6-GalNAcII gene and activity of the CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase were higher in IgA1-producing cell lines from IgAN patients than in such cells from healthy controls.	N-Acetylneuraminic Acid	60-65	immunoglobulin heavy constant alpha 1	Homo sapiens	73-77
17418236-7	2007	Expression of the ST6-GalNAcII gene and activity of the CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase were higher in IgA1-producing cell lines from IgAN patients than in such cells from healthy controls.	N-Acetylneuraminic Acid	60-65	immunoglobulin heavy constant alpha 1	Homo sapiens	120-124
17382908-0	2007	Overexpression of membrane sialic acid-specific sialidase Neu3 inhibits matrix metalloproteinase-9 expression in vascular smooth muscle cells.	N-Acetylneuraminic Acid	27-38	neuraminidase 3	Homo sapiens	58-62
17382908-0	2007	Overexpression of membrane sialic acid-specific sialidase Neu3 inhibits matrix metalloproteinase-9 expression in vascular smooth muscle cells.	N-Acetylneuraminic Acid	27-38	matrix metallopeptidase 9	Homo sapiens	72-98
17374613-8	2007	In fact, three cytosolic glycoproteins, in the range 45-66 kDa, showed a 50-70% decrease of their sialic acid content upon Neu2 expression, supporting their possible role as modulators of the Bcr-Abl complex.	N-Acetylneuraminic Acid	98-109	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	192-199
17490484-1	2007	BACKGROUND: Human influenza viruses are known to bind to sialic acid linked alpha2-6 to galactose, but the binding specificity beyond that linkage has not been systematically examined.	N-Acetylneuraminic Acid	57-68	immunoglobulin binding protein 1	Homo sapiens	76-84
17336432-7	2007	This endocytosis is inhibited by neuraminidase, suggesting that it is mediated by sialic acid present on cell surface.	N-Acetylneuraminic Acid	82-93	neuraminidase 1	Homo sapiens	33-46
17368571-1	2007	The function of gangliosides, sialic acid-containing glycolipids, on the secretion and assembly of apoB-containing lipoproteins is poorly understood.	N-Acetylneuraminic Acid	30-41	apolipoprotein B	Homo sapiens	99-103
17321601-10	2007	Enzymatic treatment with neuraminidase, that cleaves terminal sialic acid residues, completely abolished boAGP"s anti-apoptotic activity.	N-Acetylneuraminic Acid	62-73	neuraminidase 1	Bos taurus	25-38
17327233-5	2007	Finally, we report that N-acetyl neuraminic acid can reproduce the effects of elastin peptides on both ERK1/2 activation and pro-MMP-1 production.	N-Acetylneuraminic Acid	24-48	elastin	Homo sapiens	78-85
17327233-5	2007	Finally, we report that N-acetyl neuraminic acid can reproduce the effects of elastin peptides on both ERK1/2 activation and pro-MMP-1 production.	N-Acetylneuraminic Acid	24-48	mitogen-activated protein kinase 3	Homo sapiens	103-109
17327233-5	2007	Finally, we report that N-acetyl neuraminic acid can reproduce the effects of elastin peptides on both ERK1/2 activation and pro-MMP-1 production.	N-Acetylneuraminic Acid	24-48	matrix metallopeptidase 1	Homo sapiens	129-134
17327233-6	2007	Altogether, our results indicate that the enzymatic activity of the Neu-1 subunit of the elastin receptor complex is responsible for its signal transduction, presumably through sialic acid generation from undetermined substrates.	N-Acetylneuraminic Acid	177-188	neuraminidase 1	Homo sapiens	68-73
17327233-6	2007	Altogether, our results indicate that the enzymatic activity of the Neu-1 subunit of the elastin receptor complex is responsible for its signal transduction, presumably through sialic acid generation from undetermined substrates.	N-Acetylneuraminic Acid	177-188	elastin	Homo sapiens	89-96
17303571-7	2007	Analysis of Pmel17 processing in glycosylation-deficient mutant cells reveals that Pmel17 lacking the correct addition of sialic acid and galactose loses the ability to form fibrils.	N-Acetylneuraminic Acid	122-133	premelanosome protein	Homo sapiens	83-89
17303571-8	2007	Furthermore, we show that addition of sialic acid affects the stability and sorting of Pmel17 and reduces pigmentation.	N-Acetylneuraminic Acid	38-49	premelanosome protein	Homo sapiens	87-93
17760270-4	2007	Disialyl Lewis a in normal epithelial cells serves as a ligand for immunosuppressive receptors such as sialic acid binding immunoglobulin (Ig)-like lectins (siglec-7) and -9 expressed on resident monocytes/macrophages and maintains immunological homeostasis of mucosal membranes in digestive organs.	N-Acetylneuraminic Acid	103-114	sialic acid binding Ig like lectin 7	Homo sapiens	157-173
17388810-7	2007	Removal of sialic acid from the outer plasma membrane caused a redistribution of K-Ras to recycling endosomes.	N-Acetylneuraminic Acid	11-22	KRAS proto-oncogene, GTPase	Homo sapiens	81-86
17044044-11	2007	From this last result we hypothesize that a neuraminidase from cortical granules would probably participate in the block to polyspermy by removing sialic acid from the ZP.	N-Acetylneuraminic Acid	147-158	neuraminidase 1	Bos taurus	44-57
17321601-11	2007	These results suggest that the protective effect of AGP is likely mediated by its sialic acid terminal groups.	N-Acetylneuraminic Acid	82-93	alpha-1-acid glycoprotein	Bos taurus	52-55
17031641-0	2007	N-acetylneuraminic acid coupled human recombinant TNFalpha exhibits enhanced anti-tumor activity against Meth-A fibrosarcoma and reduced toxicity.	N-Acetylneuraminic Acid	0-23	tumor necrosis factor	Homo sapiens	50-58
17360250-9	2007	An O-linked glycan with a mass of 656 Da and terminating with a sialic acid residue was detected on a minor proportion of Gc globulin molecules.	N-Acetylneuraminic Acid	64-75	GC vitamin D binding protein	Homo sapiens	122-133
17031641-1	2007	In order to study the effect of glycosylation on its biological activities and to develop tumor necrosis factor alpha (TNFalpha) with less deleterious effects, N-acetylneuraminic acid (NeuAc) with a C9 spacer was chemically coupled to human recombinant TNFalpha.	N-Acetylneuraminic Acid	160-183	tumor necrosis factor	Homo sapiens	90-117
17031641-1	2007	In order to study the effect of glycosylation on its biological activities and to develop tumor necrosis factor alpha (TNFalpha) with less deleterious effects, N-acetylneuraminic acid (NeuAc) with a C9 spacer was chemically coupled to human recombinant TNFalpha.	N-Acetylneuraminic Acid	160-183	tumor necrosis factor	Homo sapiens	119-127
17031641-1	2007	In order to study the effect of glycosylation on its biological activities and to develop tumor necrosis factor alpha (TNFalpha) with less deleterious effects, N-acetylneuraminic acid (NeuAc) with a C9 spacer was chemically coupled to human recombinant TNFalpha.	N-Acetylneuraminic Acid	160-183	tumor necrosis factor	Homo sapiens	253-261
17031641-2	2007	NeuAc-coupled TNFalpha (NeuAc-TNFalpha) exhibited reduced activities in vitro by about threefold compared to native TNFalpha.	N-Acetylneuraminic Acid	0-5	tumor necrosis factor	Homo sapiens	14-22
17031641-2	2007	NeuAc-coupled TNFalpha (NeuAc-TNFalpha) exhibited reduced activities in vitro by about threefold compared to native TNFalpha.	N-Acetylneuraminic Acid	0-5	tumor necrosis factor	Homo sapiens	30-38
17031641-2	2007	NeuAc-coupled TNFalpha (NeuAc-TNFalpha) exhibited reduced activities in vitro by about threefold compared to native TNFalpha.	N-Acetylneuraminic Acid	0-5	tumor necrosis factor	Homo sapiens	30-38
17031641-2	2007	NeuAc-coupled TNFalpha (NeuAc-TNFalpha) exhibited reduced activities in vitro by about threefold compared to native TNFalpha.	N-Acetylneuraminic Acid	24-29	tumor necrosis factor	Homo sapiens	14-22
17031641-2	2007	NeuAc-coupled TNFalpha (NeuAc-TNFalpha) exhibited reduced activities in vitro by about threefold compared to native TNFalpha.	N-Acetylneuraminic Acid	24-29	tumor necrosis factor	Homo sapiens	30-38
17031641-2	2007	NeuAc-coupled TNFalpha (NeuAc-TNFalpha) exhibited reduced activities in vitro by about threefold compared to native TNFalpha.	N-Acetylneuraminic Acid	24-29	tumor necrosis factor	Homo sapiens	30-38
17031641-4	2007	NeuAc-TNFalpha reduced activities in the up-regulation of serum levels of IL-6 and NOx, but comparable activity as native TNFalpha in the down-regulation of the serum level of glucose.	N-Acetylneuraminic Acid	0-5	tumor necrosis factor	Homo sapiens	6-14
17031641-4	2007	NeuAc-TNFalpha reduced activities in the up-regulation of serum levels of IL-6 and NOx, but comparable activity as native TNFalpha in the down-regulation of the serum level of glucose.	N-Acetylneuraminic Acid	0-5	interleukin 6	Homo sapiens	74-78
17031641-4	2007	NeuAc-TNFalpha reduced activities in the up-regulation of serum levels of IL-6 and NOx, but comparable activity as native TNFalpha in the down-regulation of the serum level of glucose.	N-Acetylneuraminic Acid	0-5	tumor necrosis factor	Homo sapiens	122-130
17462576-0	2007	Spin-labeled analogs of CMP-NeuAc as NMR probes of the alpha-2,6-sialyltransferase ST6Gal I.	N-Acetylneuraminic Acid	28-33	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	83-91
17031641-5	2007	However, NeuAc-TNFalpha was more potent than TNFalpha in the up-regulation of the serum level of serum amyloid A (SAA).	N-Acetylneuraminic Acid	9-14	tumor necrosis factor	Homo sapiens	15-23
17031641-5	2007	However, NeuAc-TNFalpha was more potent than TNFalpha in the up-regulation of the serum level of serum amyloid A (SAA).	N-Acetylneuraminic Acid	9-14	serum amyloid A1 cluster	Homo sapiens	97-112
17031641-5	2007	However, NeuAc-TNFalpha was more potent than TNFalpha in the up-regulation of the serum level of serum amyloid A (SAA).	N-Acetylneuraminic Acid	9-14	serum amyloid A1 cluster	Homo sapiens	114-117
17031641-6	2007	NeuAc-TNFalpha was less toxic to mice.	N-Acetylneuraminic Acid	0-5	tumor necrosis factor	Homo sapiens	6-14
17031642-0	2007	Synthesis of glycosylated human tumor necrosis factor alpha coupled with N-acetylneuraminic acid.	N-Acetylneuraminic Acid	73-96	tumor necrosis factor	Homo sapiens	32-59
17031642-1	2007	In order to study the effect of glycosylation on its biological activities, and to develop TNFalpha with less deleterious effects, recombinant human TNFalpha was chemically coupled with N-acetylneuraminic acid (NeuAc).	N-Acetylneuraminic Acid	186-209	tumor necrosis factor	Homo sapiens	91-99
17031642-1	2007	In order to study the effect of glycosylation on its biological activities, and to develop TNFalpha with less deleterious effects, recombinant human TNFalpha was chemically coupled with N-acetylneuraminic acid (NeuAc).	N-Acetylneuraminic Acid	186-209	tumor necrosis factor	Homo sapiens	149-157
17031642-1	2007	In order to study the effect of glycosylation on its biological activities, and to develop TNFalpha with less deleterious effects, recombinant human TNFalpha was chemically coupled with N-acetylneuraminic acid (NeuAc).	N-Acetylneuraminic Acid	211-216	tumor necrosis factor	Homo sapiens	149-157
17031642-2	2007	NeuAc with C9 spacer was coupled to TNFalpha by acyl azide method.	N-Acetylneuraminic Acid	0-5	tumor necrosis factor	Homo sapiens	36-44
17031642-4	2007	NeuAc coupling to TNFalpha was confirmed by lectin blotting.	N-Acetylneuraminic Acid	0-5	tumor necrosis factor	Homo sapiens	18-26
17243023-11	2007	The glycoforms of saliva and lung gp-340 mediated differential aggregation of Le(b)- (Helicobacter pylori), sialylpolylactosamine- (Streptococcus suis) or sialic acid- (Streptococcus mutans) binding bacteria.	N-Acetylneuraminic Acid	155-166	deleted in malignant brain tumors 1	Homo sapiens	34-40
17235685-3	2007	The key enzyme of sialic acid biosynthesis is the bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE), which catalyzes the first two steps of sialic acid biosynthesis in the cytosol.	N-Acetylneuraminic Acid	18-29	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	127-130
17235685-3	2007	The key enzyme of sialic acid biosynthesis is the bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE), which catalyzes the first two steps of sialic acid biosynthesis in the cytosol.	N-Acetylneuraminic Acid	172-183	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	127-130
17326675-4	2007	The binding of both mAbs to their epitopes on the N-domain of ACE is significantly diminished by the presence of the C-domain in the two-domain somatic tissue ACE and further diminished by the presence of sialic acid residues on the surface of blood ACE.	N-Acetylneuraminic Acid	205-216	angiotensin I converting enzyme	Homo sapiens	62-65
17242043-6	2007	Radioactive re-N-acetylation of the antigen yielded a GD3-like ganglioside with the radioactive label on the external sialic acid.	N-Acetylneuraminic Acid	118-129	GRDX	Homo sapiens	54-57
17326675-7	2007	As a result, the regions of the epitopes for mAb 1G12 and 6A12 on the N-domain, shielded in somatic ACE by the C-domain globule and additionally shielded in blood ACE by sialic acid residues in the oligosaccharide chains localized on Asn289 and Asn416, become unmasked.	N-Acetylneuraminic Acid	170-181	angiotensin I converting enzyme	Homo sapiens	100-103
17326675-7	2007	As a result, the regions of the epitopes for mAb 1G12 and 6A12 on the N-domain, shielded in somatic ACE by the C-domain globule and additionally shielded in blood ACE by sialic acid residues in the oligosaccharide chains localized on Asn289 and Asn416, become unmasked.	N-Acetylneuraminic Acid	170-181	angiotensin I converting enzyme	Homo sapiens	163-166
17291461-8	2007	Topical application of neuraminidase to selectively remove sialic acid residues on the extracellular membrane normalized the depolarized Vm and inhibited both spontaneous and evoked SMPO.	N-Acetylneuraminic Acid	59-70	neuraminidase 1	Homo sapiens	23-36
17135710-7	2007	Furthermore, western blot analysis demonstrated that the CD44 of the in vitro-matured cumulus-oocyte complexes (COCs) had a larger molecular weight and more terminal sialic acid, which has been proven to inhibit the hyaluronan-binding ability of the receptor, than the CD44 of the in vivo-matured COCs, indicating that the hyaluronan-CD44 interactions during in vitro maturation might be insufficient compared with those in vivo.	N-Acetylneuraminic Acid	166-177	CD44	Sus scrofa	57-61
17275907-6	2007	Only HAA and HPA bound exclusively to IgA1, with its O-linked glycans composed of GalNAc, galactose, and sialic acid.	N-Acetylneuraminic Acid	105-116	immunoglobulin heavy constant alpha 1	Homo sapiens	38-42
17296732-5	2007	In mouse germinal center B cells, the expression of the GL7 epitope was upregulated due to the in situ repression of CMP-Neu5Ac hydroxylase (Cmah), the enzyme responsible for Sia modification of Neu5Ac to Neu5Gc.	N-Acetylneuraminic Acid	121-127	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Mus musculus	141-145
17308665-5	2007	To date, non-natural forms of sialic acid, GalNAc, GlcNAc, and fucose have been incorporated into glycoconjugates that appear on the cell surface; in addition O-GlcNAc protein modification involved in intracellular signaling has been tagged with modified forms of this sugar.	N-Acetylneuraminic Acid	30-41	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	159-167
17292865-1	2007	The CMP-sialic acid synthetase (CSS) catalyzes the activation of sialic acid (Sia) to CMP-Sia which is a donor substrate of sialyltransferases.	N-Acetylneuraminic Acid	78-81	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	4-30
17090649-2	2007	VWF contains several carbohydrate structures, including O-linked glycans that primarily consist of sialylated T antigen (NeuAc(alpha2-3)Gal-(beta1-3)-[NeuAc(alpha2-6)]GalNAc).	N-Acetylneuraminic Acid	121-126	von Willebrand factor	Homo sapiens	0-3
17090649-2	2007	VWF contains several carbohydrate structures, including O-linked glycans that primarily consist of sialylated T antigen (NeuAc(alpha2-3)Gal-(beta1-3)-[NeuAc(alpha2-6)]GalNAc).	N-Acetylneuraminic Acid	151-156	von Willebrand factor	Homo sapiens	0-3
17090649-2	2007	VWF contains several carbohydrate structures, including O-linked glycans that primarily consist of sialylated T antigen (NeuAc(alpha2-3)Gal-(beta1-3)-[NeuAc(alpha2-6)]GalNAc).	N-Acetylneuraminic Acid	151-156	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	141-148
17090649-2	2007	VWF contains several carbohydrate structures, including O-linked glycans that primarily consist of sialylated T antigen (NeuAc(alpha2-3)Gal-(beta1-3)-[NeuAc(alpha2-6)]GalNAc).	N-Acetylneuraminic Acid	151-156	immunoglobulin binding protein 1	Homo sapiens	157-165
17118559-6	2007	The results indicate that the interaction of Ramos cells with immobilized alpha2,6-linked sialic acid enhances XIAP expression, directly or indirectly suppressing caspase-3 activity and inhibiting anti-IgM Ab-induced apoptosis.	N-Acetylneuraminic Acid	90-101	X-linked inhibitor of apoptosis	Homo sapiens	111-115
17284758-6	2007	In the hippocampus, significant dose-response relations were observed between amount of sialic acid supplementation and mRNA levels of ST8SIA4 (P = 0.002) and GNE (P = 0.004), corresponding with proportionate increases in protein-bound sialic acid concentrations in the frontal cortex.	N-Acetylneuraminic Acid	88-99	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	135-142
17284758-6	2007	In the hippocampus, significant dose-response relations were observed between amount of sialic acid supplementation and mRNA levels of ST8SIA4 (P = 0.002) and GNE (P = 0.004), corresponding with proportionate increases in protein-bound sialic acid concentrations in the frontal cortex.	N-Acetylneuraminic Acid	88-99	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	159-162
17284758-6	2007	In the hippocampus, significant dose-response relations were observed between amount of sialic acid supplementation and mRNA levels of ST8SIA4 (P = 0.002) and GNE (P = 0.004), corresponding with proportionate increases in protein-bound sialic acid concentrations in the frontal cortex.	N-Acetylneuraminic Acid	236-247	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	135-142
17284758-6	2007	In the hippocampus, significant dose-response relations were observed between amount of sialic acid supplementation and mRNA levels of ST8SIA4 (P = 0.002) and GNE (P = 0.004), corresponding with proportionate increases in protein-bound sialic acid concentrations in the frontal cortex.	N-Acetylneuraminic Acid	236-247	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	159-162
17253773-8	2007	This is the first detailed report showing a direct association between GM1 and alpha-synuclein, which is attributed to specific interaction between helical alpha-synuclein and both the sialic acid and carbohydrate moieties of GM1.	N-Acetylneuraminic Acid	185-196	synuclein alpha	Homo sapiens	79-94
17253773-8	2007	This is the first detailed report showing a direct association between GM1 and alpha-synuclein, which is attributed to specific interaction between helical alpha-synuclein and both the sialic acid and carbohydrate moieties of GM1.	N-Acetylneuraminic Acid	185-196	synuclein alpha	Homo sapiens	156-171
16937399-4	2007	By increasing the concentration of these amino acids we increased recombinant human erythropoietin (rHuEPO) biosynthesis in the last harvest cycle as expected but, surprisingly, we also observed a large increase in the amount of rHuEPO with a relatively low sialic acid content.	N-Acetylneuraminic Acid	258-269	erythropoietin	Homo sapiens	84-98
17138568-1	2007	CD33-related Siglecs (sialic acid-binding immunoglobulin-like lectins) 5-11 are inhibitory receptors that contain a membrane proximal ITIM (immunoreceptor tyrosine-based inhibitory motif) (I/V/L/)XYXX(L/V), which can recruit SHP-1/2.	N-Acetylneuraminic Acid	22-33	CD33 molecule	Homo sapiens	0-4
17138568-1	2007	CD33-related Siglecs (sialic acid-binding immunoglobulin-like lectins) 5-11 are inhibitory receptors that contain a membrane proximal ITIM (immunoreceptor tyrosine-based inhibitory motif) (I/V/L/)XYXX(L/V), which can recruit SHP-1/2.	N-Acetylneuraminic Acid	22-33	nuclear receptor subfamily 0 group B member 2	Homo sapiens	225-232
17137591-2	2007	Previously reported structures of the N-terminal domain of the Siglec sialoadhesin (SnD1) in complex with various sialic acid analogs revealed the structural template for sialic acid binding.	N-Acetylneuraminic Acid	114-125	sialic acid binding Ig like lectin 1	Homo sapiens	70-82
17137591-2	2007	Previously reported structures of the N-terminal domain of the Siglec sialoadhesin (SnD1) in complex with various sialic acid analogs revealed the structural template for sialic acid binding.	N-Acetylneuraminic Acid	114-125	staphylococcal nuclease and tudor domain containing 1	Homo sapiens	84-88
17137591-2	2007	Previously reported structures of the N-terminal domain of the Siglec sialoadhesin (SnD1) in complex with various sialic acid analogs revealed the structural template for sialic acid binding.	N-Acetylneuraminic Acid	171-182	sialic acid binding Ig like lectin 1	Homo sapiens	70-82
17137591-2	2007	Previously reported structures of the N-terminal domain of the Siglec sialoadhesin (SnD1) in complex with various sialic acid analogs revealed the structural template for sialic acid binding.	N-Acetylneuraminic Acid	171-182	staphylococcal nuclease and tudor domain containing 1	Homo sapiens	84-88
17137591-4	2007	These structures reveal that SnD1 undergoes very few structural changes on ligand binding and detail how two novel classes of sialic acid analogs bind, one of which unexpectedly can induce Siglec dimerization.	N-Acetylneuraminic Acid	126-137	staphylococcal nuclease and tudor domain containing 1	Homo sapiens	29-33
17268079-7	2007	The reaction to SSA but not to MAM suggested the presence of sialic acid linked alpha2,6 to galactose in both cellular and serum TNX.	N-Acetylneuraminic Acid	61-72	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6	Mus musculus	80-88
17268079-7	2007	The reaction to SSA but not to MAM suggested the presence of sialic acid linked alpha2,6 to galactose in both cellular and serum TNX.	N-Acetylneuraminic Acid	61-72	tenascin XB	Mus musculus	129-132
17008544-1	2007	CD33 is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family of inhibitory receptors and a therapeutic target for acute myeloid leukemia (AML).	N-Acetylneuraminic Acid	24-35	CD33 molecule	Homo sapiens	0-4
17118559-6	2007	The results indicate that the interaction of Ramos cells with immobilized alpha2,6-linked sialic acid enhances XIAP expression, directly or indirectly suppressing caspase-3 activity and inhibiting anti-IgM Ab-induced apoptosis.	N-Acetylneuraminic Acid	90-101	caspase 3	Homo sapiens	163-172
17126533-2	2007	The protein encoded by this gene has an important role in neural development and sialic acid synthesis on the neural cell adhesion molecule (NCAM).	N-Acetylneuraminic Acid	81-92	neural cell adhesion molecule 1	Homo sapiens	110-139
17223599-0	2007	Amino acid change 335 E to K affects the sialic-acid-binding and neuraminidase activities of Urabe AM9 mumps virus hemagglutinin-neuraminidase glycoprotein.	N-Acetylneuraminic Acid	41-52	hemagglutinin-neuraminidase	Mumps orthorubulavirus	115-142
17101770-2	2007	The ST3Gal-I sialyltransferase is a candidate mechanistic component and catalyzes sialic acid addition to core 1 O-glycans during protein O glycosylation.	N-Acetylneuraminic Acid	82-93	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	4-12
17126533-2	2007	The protein encoded by this gene has an important role in neural development and sialic acid synthesis on the neural cell adhesion molecule (NCAM).	N-Acetylneuraminic Acid	81-92	neural cell adhesion molecule 1	Homo sapiens	141-145
16729195-5	2007	SAS, the enzyme catalyzing synthesis of N-acetyl-neuraminic acid (syn: sialic acid) was represented as a single spot and found to be significantly and manifold reduced (P &lt; 0.01) in cortex of fetuses with DS (control vs. DS, 0.052 +/- 0.025 vs. 0.012 +/- 0.006).	N-Acetylneuraminic Acid	71-82	N-acetylneuraminate synthase	Homo sapiens	0-3
17261181-2	2007	The causative gene, GNE, codes for UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, which catalyzes the first two reactions in the synthesis of sialic acid.	N-Acetylneuraminic Acid	159-170	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	20-23
17261181-2	2007	The causative gene, GNE, codes for UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, which catalyzes the first two reactions in the synthesis of sialic acid.	N-Acetylneuraminic Acid	159-170	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	35-97
17164266-1	2007	Distal myopathy with rimmed vacuoles (DMRV) or hereditary inclusion myopathy (h-IBM) is an early adult-onset distal myopathy caused by mutations in the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) gene which encodes for a bifunctional enzyme involved in sialic acid biosynthesis.	N-Acetylneuraminic Acid	278-289	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	152-214
17185412-6	2007	Their protein receptors, synaptotagmins I and II, bind to a pocket at the tip of their H(CC) (C-terminal domain of the C-terminal fragment of the heavy chain) that corresponds to the unique second carbohydrate binding site of tetanus neurotoxin, the sialic acid binding site.	N-Acetylneuraminic Acid	250-261	synaptotagmin I	Mus musculus	25-48
16729195-3	2007	AIMS: As sialylation of glycoconjugates plays an important role in brain development, this study aimed to look at the sialic acid metabolism by measuring sialic acid synthase (SAS; N-acetylneuraminate synthase) in early second trimester fetal control and DS brain.	N-Acetylneuraminic Acid	118-129	N-acetylneuraminate synthase	Homo sapiens	154-174
16729195-3	2007	AIMS: As sialylation of glycoconjugates plays an important role in brain development, this study aimed to look at the sialic acid metabolism by measuring sialic acid synthase (SAS; N-acetylneuraminate synthase) in early second trimester fetal control and DS brain.	N-Acetylneuraminic Acid	118-129	N-acetylneuraminate synthase	Homo sapiens	176-179
16729195-3	2007	AIMS: As sialylation of glycoconjugates plays an important role in brain development, this study aimed to look at the sialic acid metabolism by measuring sialic acid synthase (SAS; N-acetylneuraminate synthase) in early second trimester fetal control and DS brain.	N-Acetylneuraminic Acid	118-129	N-acetylneuraminate synthase	Homo sapiens	181-209
16729195-7	2007	Decreased SAS may well lead to altered sialic acid metabolism, required for brain development and, more specifically, for sialylation of key brain proteins, including neuronal cell adhesion molecule and myelin associated glycoprotein.	N-Acetylneuraminic Acid	39-50	N-acetylneuraminate synthase	Homo sapiens	10-13
16729195-5	2007	SAS, the enzyme catalyzing synthesis of N-acetyl-neuraminic acid (syn: sialic acid) was represented as a single spot and found to be significantly and manifold reduced (P &lt; 0.01) in cortex of fetuses with DS (control vs. DS, 0.052 +/- 0.025 vs. 0.012 +/- 0.006).	N-Acetylneuraminic Acid	40-64	N-acetylneuraminate synthase	Homo sapiens	0-3
16729195-7	2007	Decreased SAS may well lead to altered sialic acid metabolism, required for brain development and, more specifically, for sialylation of key brain proteins, including neuronal cell adhesion molecule and myelin associated glycoprotein.	N-Acetylneuraminic Acid	39-50	neuronal cell adhesion molecule	Homo sapiens	167-198
17103087-12	2007	IgA denuded of sialic acid is recognized, bound, and cleared by hepatic asialoglycoprotein receptor (ASGPR).	N-Acetylneuraminic Acid	15-26	CD79a molecule	Homo sapiens	0-3
17103087-12	2007	IgA denuded of sialic acid is recognized, bound, and cleared by hepatic asialoglycoprotein receptor (ASGPR).	N-Acetylneuraminic Acid	15-26	asialoglycoprotein receptor 1	Homo sapiens	72-99
17103087-12	2007	IgA denuded of sialic acid is recognized, bound, and cleared by hepatic asialoglycoprotein receptor (ASGPR).	N-Acetylneuraminic Acid	15-26	asialoglycoprotein receptor 1	Homo sapiens	101-106
16982154-2	2006	We and others have shown that Abeta binds with relatively high affinity to clustered sialic acid residues on cell surfaces and that removal of cell surface sialic acids attenuate Abeta toxicity.	N-Acetylneuraminic Acid	85-96	amyloid beta precursor protein	Homo sapiens	30-35
17088346-8	2007	Removal of negatively charged sialic acid residues by pretreatment of mucus with neuraminidase diminished the antiadhesive effect of encapsulation.	N-Acetylneuraminic Acid	30-41	neuraminidase 1	Homo sapiens	81-94
17165777-9	2006	It was shown that wild-type NAL could not be used for the highly stereoselective synthesis of a 6-dipropylamide sialic acid mimetic because the 4S-configured product was only approximately 3-fold kinetically favored and only approximately 3-fold thermodynamically favored over the alternative 4R-configured product.	N-Acetylneuraminic Acid	112-123	N-acetylneuraminate pyruvate lyase	Homo sapiens	28-31
17118363-0	2006	The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.	N-Acetylneuraminic Acid	205-216	collapsin response mediator protein 1	Homo sapiens	4-41
17118363-0	2006	The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.	N-Acetylneuraminic Acid	205-216	collapsin response mediator protein 1	Homo sapiens	43-49
17118363-0	2006	The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.	N-Acetylneuraminic Acid	205-216	zinc finger and BTB domain containing 16	Homo sapiens	59-101
17118363-0	2006	The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.	N-Acetylneuraminic Acid	205-216	zinc finger and BTB domain containing 16	Homo sapiens	103-107
17118363-0	2006	The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.	N-Acetylneuraminic Acid	205-216	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	117-179
17118363-0	2006	The collapsin response mediator protein 1 (CRMP-1) and the promyelocytic leukemia zinc finger protein (PLZF) bind to UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme of sialic acid biosynthesis.	N-Acetylneuraminic Acid	205-216	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	181-184
17191668-9	2006	Our conclusion is that open surgery decreased the level of IGFBP-3 compared with laparoscopy, whereas patients with gallbladder inflammation that underwent laparoscopy had an increased content of sialic acid in IGFBP-3.	N-Acetylneuraminic Acid	196-207	insulin like growth factor binding protein 3	Homo sapiens	211-218
17957128-5	2007	The glycosylation profile in the carbohydrate moieties of these differently charged IgA1 was analyzed by galactose (Gal)-, galactose-acetylgalactosamine (Gal-GalNAc)-, or sialic acid-specific enzyme-linked lectin binding assays (ELLA).	N-Acetylneuraminic Acid	171-182	immunoglobulin heavy constant alpha 1	Homo sapiens	84-88
17171781-4	2007	In addition, MS(3) spectra derived from D-type fragment ions clearly differentiate the alpha2-3- or alpha2-6-linked sialic acid on the alpha1-6 antenna due to their characteristic spectral patterns.	N-Acetylneuraminic Acid	116-127	immunoglobulin binding protein 1	Homo sapiens	100-108
17171781-4	2007	In addition, MS(3) spectra derived from D-type fragment ions clearly differentiate the alpha2-3- or alpha2-6-linked sialic acid on the alpha1-6 antenna due to their characteristic spectral patterns.	N-Acetylneuraminic Acid	116-127	adrenoceptor alpha 1D	Homo sapiens	135-143
17165810-2	2006	However, CDT is not a single molecular entity but refers to a group of sialic acid-deficient transferrin isoforms from mono- to trisialotransferrin.	N-Acetylneuraminic Acid	71-82	transferrin	Homo sapiens	93-104
16982154-5	2006	Soluble sialic acid attenuation of Abeta induced toxicity was effective only at high sialic acid concentrations and low Abeta concentration.	N-Acetylneuraminic Acid	8-19	amyloid beta precursor protein	Homo sapiens	35-40
16982154-5	2006	Soluble sialic acid attenuation of Abeta induced toxicity was effective only at high sialic acid concentrations and low Abeta concentration.	N-Acetylneuraminic Acid	8-19	amyloid beta precursor protein	Homo sapiens	120-125
16982154-5	2006	Soluble sialic acid attenuation of Abeta induced toxicity was effective only at high sialic acid concentrations and low Abeta concentration.	N-Acetylneuraminic Acid	85-96	amyloid beta precursor protein	Homo sapiens	35-40
16820145-7	2006	Lp(a) also showed significant positive correlations with pulse pressure, fibrinogen, sialic acid, apolipoprotein B and apolipoprotein B/apolipoprotein A-I ratio.	N-Acetylneuraminic Acid	85-96	lipoprotein(a)	Homo sapiens	0-5
16817909-6	2006	HeLa cells treated with neuraminidase did not bind SP41, suggesting the involvement of cellular sialic acid residues in this interaction.	N-Acetylneuraminic Acid	96-107	neuraminidase 1	Homo sapiens	24-37
17111351-3	2006	Previous studies using sialidase treatment suggested a role of sialic acid residues in L-selectin-dependent rolling.	N-Acetylneuraminic Acid	63-74	selectin, lymphocyte	Mus musculus	87-97
16987814-3	2006	We found that glutamate-elicited NMDA receptor currents in cultured hippocampal neurons were reduced by approximately 30% with the application of polysialic acid or polysialylated NCAM but not by the sialic acid monomer, chondroitin sulfate, or non-polysialylated NCAM.	N-Acetylneuraminic Acid	150-161	neural cell adhesion molecule 1	Homo sapiens	264-268
16981714-6	2006	Enzymatic removal of sialic acid or the entire glycosidic moiety equally enhanced PTX3 binding to C1q compared to that in the native protein, thus indicating that glycosylation substantially contributes to modulate PTX3/C1q interaction and that sialic acid is the main determinant of this contribution.	N-Acetylneuraminic Acid	21-32	pentraxin 3	Homo sapiens	82-86
16877748-10	2006	These results show that the N-glycans that enhance the MIP-2-inducing activity of mouse sICAM-1 are mostly di- and trisialylated complex-type N-glycans including a small fraction carrying more sialic acid residues than antennae and that the nine N-glycosylation sites of mouse sICAM-1 are all glycosylated.	N-Acetylneuraminic Acid	193-204	chemokine (C-X-C motif) ligand 2	Mus musculus	55-60
17012248-10	2006	The "essential arginine" critical for sialic acid recognition in both Siglec-14 and Siglec-5 is present in humans but mutated in almost all great ape alleles.	N-Acetylneuraminic Acid	38-49	sialic acid binding Ig like lectin 14	Homo sapiens	70-79
17012248-10	2006	The "essential arginine" critical for sialic acid recognition in both Siglec-14 and Siglec-5 is present in humans but mutated in almost all great ape alleles.	N-Acetylneuraminic Acid	38-49	sialic acid binding Ig like lectin 5	Homo sapiens	84-92
16969505-4	2006	Flow cytometric analysis using Limax flavus agglutinin, a sialic acid-specific lectin, showed that sialylated glycoconjugates are present on the surface of HBL-2 cells and that they were removed by neuraminidase.	N-Acetylneuraminic Acid	58-69	neuraminidase 1	Homo sapiens	198-211
16806174-0	2006	Nonhuman sialic acid Neu5Gc is very low in human embryonic stem cell-derived neural precursors differentiated with B27/N2 and noggin: implications for transplantation.	N-Acetylneuraminic Acid	9-20	noggin	Homo sapiens	126-132
16857734-1	2006	Siglec-7 is a CD33-related sialic acid-binding Ig-like lectin expressed strongly on NK cells, where it can function as an inhibitory receptor.	N-Acetylneuraminic Acid	27-38	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
16857734-2	2006	Its sialic acid-binding activity on NK cells is masked by cis interactions with sialylated glycans, which are likely to be important for regulating the inhibitory function of Siglec-7, which exhibits an unusual preference for alpha2,8-linked disialic acids, a motif found in "b-series" gangliosides and some glycoproteins.	N-Acetylneuraminic Acid	4-15	sialic acid binding Ig like lectin 7	Homo sapiens	175-183
16857734-6	2006	Two human IgM antibodies, Ha1 and Pi1, with specificity for the alpha2,8-disialyl motif reacted strongly with NK cells in a sialic acid-dependent manner and less strongly with T cells and monocytes.	N-Acetylneuraminic Acid	124-135	Rho GTPase activating protein 45	Homo sapiens	26-29
16857734-6	2006	Two human IgM antibodies, Ha1 and Pi1, with specificity for the alpha2,8-disialyl motif reacted strongly with NK cells in a sialic acid-dependent manner and less strongly with T cells and monocytes.	N-Acetylneuraminic Acid	124-135	serpin family A member 1	Homo sapiens	34-37
16981714-6	2006	Enzymatic removal of sialic acid or the entire glycosidic moiety equally enhanced PTX3 binding to C1q compared to that in the native protein, thus indicating that glycosylation substantially contributes to modulate PTX3/C1q interaction and that sialic acid is the main determinant of this contribution.	N-Acetylneuraminic Acid	21-32	complement C1q A chain	Homo sapiens	98-101
16918959-10	2006	The amount of sialic acid in IGFBP-3 was determined by affinity chromatography.	N-Acetylneuraminic Acid	14-25	insulin like growth factor binding protein 3	Homo sapiens	29-36
16847058-0	2006	Roles for UDP-GlcNAc 2-epimerase/ManNAc 6-kinase outside of sialic acid biosynthesis: modulation of sialyltransferase and BiP expression, GM3 and GD3 biosynthesis, proliferation, and apoptosis, and ERK1/2 phosphorylation.	N-Acetylneuraminic Acid	60-71	mitogen-activated protein kinase 3	Homo sapiens	198-204
16847058-1	2006	Roles for UDP-GlcNAc 2-epimerase/ManNAc 6-kinase (GNE) beyond controlling flux into the sialic acid biosynthetic pathway by converting UDP-GlcNAc to N-acetylmannosamine are described in this report.	N-Acetylneuraminic Acid	88-99	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	50-53
16847058-9	2006	These results provide examples of specific biochemical pathways, other than sialic acid metabolism, that are influenced by GNE.	N-Acetylneuraminic Acid	76-87	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	123-126
16918959-17	2006	A significant increase in the sialic acid content of IGFBP-3 was seen in both patient groups when compared to healthy subjects.	N-Acetylneuraminic Acid	30-41	insulin like growth factor binding protein 3	Homo sapiens	53-60
16546301-1	2006	Alcoholics have an increase in sialic acid-deficient glycoconjugates such as carbohydrate-deficient transferrin, sialic acid-deficient gangliosides and free sialic acids.	N-Acetylneuraminic Acid	31-42	transferrin	Rattus norvegicus	100-111
16923886-5	2006	This pathway involves O acetylation of monomeric sialic acid and is regulated by another bifunctional enzyme, NeuA, which includes N-terminal synthetase and C-terminal sialyl O-esterase domains.	N-Acetylneuraminic Acid	49-60	alpha/beta fold hydrolase	Pasteurella multocida	177-185
16925670-11	2006	Neuraminidase treatment indicated the presence of, not only the H-D antigen, but also other sialic acid antigens which reacted with the human natural antibody, especially IgG.	N-Acetylneuraminic Acid	92-103	neuraminidase 1	Homo sapiens	0-13
16887986-2	2006	In this study, we investigated the role of the sialic acid binding Ig-like lectin sialoadhesin (Sn, Siglec-1) in a model of interphotoreceptor retinal binding protein peptide-induced experimental autoimmune uveoretinitis in mice with targeted deletion of Sn.	N-Acetylneuraminic Acid	47-58	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	82-94
16887986-2	2006	In this study, we investigated the role of the sialic acid binding Ig-like lectin sialoadhesin (Sn, Siglec-1) in a model of interphotoreceptor retinal binding protein peptide-induced experimental autoimmune uveoretinitis in mice with targeted deletion of Sn.	N-Acetylneuraminic Acid	47-58	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	96-98
16855749-7	2006	The target compound is a useful intermediate for synthesis of a variety of C-4 substituted sialic acid derivatives, and it is synthesised by a modular route.	N-Acetylneuraminic Acid	91-102	complement C4A (Rodgers blood group)	Homo sapiens	75-78
16715535-1	2006	Free sialic acid storage disorders, Salla disease (SD) and Infantile sialic acid storage disease (ISSD), are lysosomal storage diseases due to impaired function of a sialic acid transporter, sialin, at the lysosomal membrane.	N-Acetylneuraminic Acid	5-16	solute carrier family 17 member 5	Homo sapiens	191-197
16715535-1	2006	Free sialic acid storage disorders, Salla disease (SD) and Infantile sialic acid storage disease (ISSD), are lysosomal storage diseases due to impaired function of a sialic acid transporter, sialin, at the lysosomal membrane.	N-Acetylneuraminic Acid	69-80	solute carrier family 17 member 5	Homo sapiens	191-197
16897185-5	2006	In support of this observation, the cDNA microarray assay and reverse transcription-polymerase chain reaction (RT-PCR) analysis showed that the gene expression of the alpha-2,6-sialyltransferase I (ST6Gal I), which transfers sialic acid to galactose residues of N-glycans, decreases in the aged cells.	N-Acetylneuraminic Acid	225-236	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	198-206
16650392-3	2006	Specifically, the use of sialyltransferases and fucosyltransferases enabled us to synthesize and purify 24 blood group and tumor-associated pLN derivatives with alpha-(2--&gt;3)- and alpha-(2--&gt;6)-linked sialic acid, as well as with alpha-(1--&gt;2)- and alpha-(1--&gt;3)-linked fucose.	N-Acetylneuraminic Acid	207-218	phospholamban	Homo sapiens	140-143
16716409-2	2006	The antigen recognized by MOMA-1 has yet to be characterized, but its expression pattern is similar to that of sialoadhesin (Sn, CD169, Siglec-1), a member of the sialic acid binding Ig-like lectin (Siglec) family.	N-Acetylneuraminic Acid	163-174	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	111-123
16716409-2	2006	The antigen recognized by MOMA-1 has yet to be characterized, but its expression pattern is similar to that of sialoadhesin (Sn, CD169, Siglec-1), a member of the sialic acid binding Ig-like lectin (Siglec) family.	N-Acetylneuraminic Acid	163-174	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	125-127
16716409-2	2006	The antigen recognized by MOMA-1 has yet to be characterized, but its expression pattern is similar to that of sialoadhesin (Sn, CD169, Siglec-1), a member of the sialic acid binding Ig-like lectin (Siglec) family.	N-Acetylneuraminic Acid	163-174	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	129-134
16716409-2	2006	The antigen recognized by MOMA-1 has yet to be characterized, but its expression pattern is similar to that of sialoadhesin (Sn, CD169, Siglec-1), a member of the sialic acid binding Ig-like lectin (Siglec) family.	N-Acetylneuraminic Acid	163-174	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	136-144
16585136-6	2006	The spectra indicate that MUC1F N-glycans have compositions consistent with high-mannose structures (Hex(5-9)HexNAc(2)) and complex/hybrid-type glycans (NeuAc(0-3)Fuc(0-3)Hex(3-8)HexNAc(3-7)).	N-Acetylneuraminic Acid	153-158	mucin 1, cell surface associated	Homo sapiens	26-30
16714565-4	2006	Pneumococcal neuraminidase cleaves sialic acid-containing substrates and is thought to be important for pneumococcal virulence.	N-Acetylneuraminic Acid	35-46	neuraminidase 1	Homo sapiens	13-26
16728277-2	2006	CD33 belongs to a family of sialic acid-binding cell surface proteins named Siglecs, among which there are 7 other functional CD33-related Siglecs (CD33rSiglecs).	N-Acetylneuraminic Acid	28-39	CD33 molecule	Homo sapiens	0-4
16728277-2	2006	CD33 belongs to a family of sialic acid-binding cell surface proteins named Siglecs, among which there are 7 other functional CD33-related Siglecs (CD33rSiglecs).	N-Acetylneuraminic Acid	28-39	CD33 molecule	Homo sapiens	126-130
16627478-8	2006	The strongly negatively charged sialic acid is the most important functional moiety of the glycopart of MT1-MMP.	N-Acetylneuraminic Acid	32-43	matrix metallopeptidase 14	Homo sapiens	104-111
16627478-9	2006	We hypothesize that sialic acid of the O-glycosylation cassette restricts the access of the catalytic domain to the hinge region and to the autolytic cleavage site and protects MT1-MMP from autolysis.	N-Acetylneuraminic Acid	20-31	matrix metallopeptidase 14	Homo sapiens	177-184
16732727-1	2006	Soluble siglecs-1, -4, -5, -6, -7, -8, -9, and -10 were probed with polyacrylamide glycoconjugates in which: 1) the Neu5Ac residue was substituted by a sulfate group (Su); 2) glycoconjugates contained both Su and Neu5Ac; 3) sialoglycoconjugates contained a tyrosine-O-sulfate residue.	N-Acetylneuraminic Acid	116-122	sialic acid binding Ig like lectin 1	Homo sapiens	8-50
16679063-3	2006	A member of the sialic acid binding Ig-like lectin (Siglec) family, Siglec-H, has recently been identified as a specific surface marker for pDCs in mice.	N-Acetylneuraminic Acid	16-27	sialic acid binding Ig-like lectin H	Mus musculus	68-76
16543244-5	2006	The interaction is mediated by glycans present on hSC and involves galactose and sialic acid residues.	N-Acetylneuraminic Acid	81-92	fucosyltransferase 1 (H blood group)	Homo sapiens	50-53
16691505-1	2006	Osteopontin (OPN) is a secreted, non-collagenous, sialic-acid rich, glycosylated adhesive phospho- protein.	N-Acetylneuraminic Acid	50-61	secreted phosphoprotein 1	Mus musculus	0-11
16397130-3	2006	Although Siglec-H has the typical structural features required for sialic acid binding, no evidence for carbohydrate recognition was obtained.	N-Acetylneuraminic Acid	67-78	sialic acid binding Ig-like lectin H	Mus musculus	9-17
16691505-1	2006	Osteopontin (OPN) is a secreted, non-collagenous, sialic-acid rich, glycosylated adhesive phospho- protein.	N-Acetylneuraminic Acid	50-61	secreted phosphoprotein 1	Mus musculus	13-16
16293595-2	2006	Herein we report the identification of the first molecular marker of mouse natural interferon-producing cells (IPCs), a novel member of the sialic acid-binding immunoglobulin (Ig)-like lectin (Siglec) family termed Siglec-H.	N-Acetylneuraminic Acid	140-151	sialic acid binding Ig-like lectin H	Mus musculus	215-223
16458537-4	2006	In the present study, we investigated the possible role of the macrophage-restricted sialic acid-binding Ig-like lectin sialoadhesin (Sn, Siglec-1) in the pathogenesis of inherited demyelination in P0(+/-) mice.	N-Acetylneuraminic Acid	85-96	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	120-132
16458537-4	2006	In the present study, we investigated the possible role of the macrophage-restricted sialic acid-binding Ig-like lectin sialoadhesin (Sn, Siglec-1) in the pathogenesis of inherited demyelination in P0(+/-) mice.	N-Acetylneuraminic Acid	85-96	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	138-146
16480686-4	2006	Lectin blot and lectin ELISA analyses showed that sialic acid and galactose residues of serum glycoproteins including transferrin were decreased in acute hepatitis.	N-Acetylneuraminic Acid	50-61	transferrin	Rattus norvegicus	118-129
16432895-3	2006	Our hypothesis was that increasing CMP-SAT in the cells through recombinant means would increase the transport of CMP-sialic acid into the Golgi, resulting in an increased CMP-sialic acid intra-lumenal pool and increased sialylation of the proteins produced.	N-Acetylneuraminic Acid	118-129	CMP-sialic acid transporter	Cricetulus griseus	35-42
16432895-3	2006	Our hypothesis was that increasing CMP-SAT in the cells through recombinant means would increase the transport of CMP-sialic acid into the Golgi, resulting in an increased CMP-sialic acid intra-lumenal pool and increased sialylation of the proteins produced.	N-Acetylneuraminic Acid	176-187	CMP-sialic acid transporter	Cricetulus griseus	35-42
16306051-1	2006	The sialyltranferase ST3Gal-V transfers a sialic acid to lactosylceramide.	N-Acetylneuraminic Acid	42-53	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	21-29
16540641-0	2006	Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells.	N-Acetylneuraminic Acid	48-59	solute carrier family 17 member 5	Homo sapiens	38-44
16540641-6	2006	Hypoxic culture markedly induced mRNA for a sialic acid transporter, sialin, and this accompanied enhanced incorporation of NeuGc as well as N-acetyl sialic acid.	N-Acetylneuraminic Acid	141-161	solute carrier family 17 member 5	Homo sapiens	69-75
16540641-7	2006	Transfection of cells with sialin gene conferred accelerated sialic acid transport and induced cell surface expression of NeuGc-G(M2).	N-Acetylneuraminic Acid	61-72	solute carrier family 17 member 5	Homo sapiens	27-33
16198015-1	2006	Complex glycoprotein biopharmaceuticals, such as follicle stimulating hormone (FSH), erythropoietin and tissue plasminogen activator consist of a range of charge isoforms due to the extent of sialic acid capping of the glycoprotein glycans.	N-Acetylneuraminic Acid	192-203	erythropoietin	Homo sapiens	85-99
16198015-1	2006	Complex glycoprotein biopharmaceuticals, such as follicle stimulating hormone (FSH), erythropoietin and tissue plasminogen activator consist of a range of charge isoforms due to the extent of sialic acid capping of the glycoprotein glycans.	N-Acetylneuraminic Acid	192-203	chromosome 20 open reading frame 181	Homo sapiens	104-132
16261579-0	2006	Recognition of tandem sialic acid residues by CD38: a theoretical study.	N-Acetylneuraminic Acid	22-33	CD38 molecule	Homo sapiens	46-50
16192407-1	2006	Beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I), the enzyme which adds sialic acid in alpha2,6-linkage on lactosaminic termini of glycoproteins, is frequently overexpressed in cancer, but its relationship with malignancy remains unclear.	N-Acetylneuraminic Acid	78-89	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	45-53
16501670-0	2006	The relationship between serum total sialic acid levels and adenosine deaminase activity in obesity.	N-Acetylneuraminic Acid	37-48	adenosine deaminase	Meleagris gallopavo	60-79
16501670-1	2006	OBJECTIVE: To evaluate the relationship between serum adenosine deaminase (AD) activity and serum total sialic acid (TSA) levels in obese individuals.	N-Acetylneuraminic Acid	104-115	adenosine deaminase	Meleagris gallopavo	54-73
16501670-1	2006	OBJECTIVE: To evaluate the relationship between serum adenosine deaminase (AD) activity and serum total sialic acid (TSA) levels in obese individuals.	N-Acetylneuraminic Acid	104-115	adenosine deaminase	Meleagris gallopavo	75-77
16261579-2	2006	Our results suggest that CD38 is likely to recognize the two phosphate groups in NAD and the two carboxyl groups in tandem sialic acid residues of gangliosides.	N-Acetylneuraminic Acid	123-134	CD38 molecule	Homo sapiens	25-29
16319059-4	2006	The ST6GalNAc-I glycosyltransferase, which can catalyze the transfer of sialic acid to GalNAc, shows a highly restricted pattern of expression in normal adult tissues, being largely limited to the gastrointestinal tract and absent in mammary gland.	N-Acetylneuraminic Acid	72-83	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	Homo sapiens	4-15
16575520-3	2006	The fact that neuraminidase treatment of the cells, or preincubation of the virus with sialic acid-containing compounds decrease the infectivity of some rotavirus strains, suggested that these viruses interact with sialic acid on the cell surface.	N-Acetylneuraminic Acid	215-226	neuraminidase 1	Homo sapiens	14-27
16449664-1	2006	Sialoadhesin (Sn, also called Siglec-1 or CD169) is a transmembrane receptor and the prototypic member of the Siglec family of sialic acid binding immunoglobulin-like lectins.	N-Acetylneuraminic Acid	127-138	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	0-12
16449664-1	2006	Sialoadhesin (Sn, also called Siglec-1 or CD169) is a transmembrane receptor and the prototypic member of the Siglec family of sialic acid binding immunoglobulin-like lectins.	N-Acetylneuraminic Acid	127-138	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	14-16
16449664-1	2006	Sialoadhesin (Sn, also called Siglec-1 or CD169) is a transmembrane receptor and the prototypic member of the Siglec family of sialic acid binding immunoglobulin-like lectins.	N-Acetylneuraminic Acid	127-138	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	30-38
16449664-1	2006	Sialoadhesin (Sn, also called Siglec-1 or CD169) is a transmembrane receptor and the prototypic member of the Siglec family of sialic acid binding immunoglobulin-like lectins.	N-Acetylneuraminic Acid	127-138	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	42-47
16387297-2	2006	Tumor necrosis factor (TNF)-alpha-induced overexpression of sialyl-Lewis x epitopes, containing sialic acid and fucose, in mucins were previously reported to be regulated by glycosyltransferase mRNAs expression through phosphatidyl inositol-specific phospholipase C (PI-PLC) signaling pathways [Ishibashi, Y., Inouye, Y., Okano, T., Taniguchi, A., 2005.	N-Acetylneuraminic Acid	96-107	tumor necrosis factor	Homo sapiens	0-33
16387297-2	2006	Tumor necrosis factor (TNF)-alpha-induced overexpression of sialyl-Lewis x epitopes, containing sialic acid and fucose, in mucins were previously reported to be regulated by glycosyltransferase mRNAs expression through phosphatidyl inositol-specific phospholipase C (PI-PLC) signaling pathways [Ishibashi, Y., Inouye, Y., Okano, T., Taniguchi, A., 2005.	N-Acetylneuraminic Acid	96-107	phospholipase C beta 1	Homo sapiens	219-265
16387297-2	2006	Tumor necrosis factor (TNF)-alpha-induced overexpression of sialyl-Lewis x epitopes, containing sialic acid and fucose, in mucins were previously reported to be regulated by glycosyltransferase mRNAs expression through phosphatidyl inositol-specific phospholipase C (PI-PLC) signaling pathways [Ishibashi, Y., Inouye, Y., Okano, T., Taniguchi, A., 2005.	N-Acetylneuraminic Acid	96-107	phospholipase C beta 1	Homo sapiens	267-273
16190864-5	2006	Hence, the specificity of sialic acid linkages on gp-340 is an important determinant of anti-IAV activity.	N-Acetylneuraminic Acid	26-37	deleted in malignant brain tumors 1	Homo sapiens	50-56
16394003-8	2006	Binding of virus-like particles to sialic acid is required because pretreatment of APCs with neuraminidase prevented the response.	N-Acetylneuraminic Acid	35-46	amyloid P component, serum	Mus musculus	83-87
16203750-10	2006	A similar effect was observed when control CETP was incubated with neuraminidase, an enzyme which is known to remove sialic acid from glycoproteins.	N-Acetylneuraminic Acid	117-128	cholesteryl ester transfer protein	Homo sapiens	43-47
16203750-10	2006	A similar effect was observed when control CETP was incubated with neuraminidase, an enzyme which is known to remove sialic acid from glycoproteins.	N-Acetylneuraminic Acid	117-128	neuraminidase 1	Homo sapiens	67-80
16958607-2	2006	The aim of this study was to compare alpha2,3- and/or alpha2,6-linked sialic acid expression on fibronectin in the seminal plasma of male partners from infertile couples.	N-Acetylneuraminic Acid	70-81	fibronectin 1	Homo sapiens	96-107
16475908-4	2006	Elevated serum SA levels might also be due to either shedding or secretion of free SA from the cell or cell membrane surface if neuraminidase levels are increased, or to the release of cellular SA-containing glycolipids and/or glycoproteins into plasma from myocardial cells after AMI.	N-Acetylneuraminic Acid	15-17	neuraminidase 1	Homo sapiens	128-141
16475908-4	2006	Elevated serum SA levels might also be due to either shedding or secretion of free SA from the cell or cell membrane surface if neuraminidase levels are increased, or to the release of cellular SA-containing glycolipids and/or glycoproteins into plasma from myocardial cells after AMI.	N-Acetylneuraminic Acid	83-85	neuraminidase 1	Homo sapiens	128-141
16475908-4	2006	Elevated serum SA levels might also be due to either shedding or secretion of free SA from the cell or cell membrane surface if neuraminidase levels are increased, or to the release of cellular SA-containing glycolipids and/or glycoproteins into plasma from myocardial cells after AMI.	N-Acetylneuraminic Acid	83-85	neuraminidase 1	Homo sapiens	128-141
16475908-9	2006	The concentrations of serum SA-rich inflammation-sensitive proteins, namely alpha1-antitrypsin, alpha2-macroglobulin and ceruloplasmin were determined immunoturbidimetrically.	N-Acetylneuraminic Acid	28-30	serpin family A member 1	Homo sapiens	76-94
16475908-9	2006	The concentrations of serum SA-rich inflammation-sensitive proteins, namely alpha1-antitrypsin, alpha2-macroglobulin and ceruloplasmin were determined immunoturbidimetrically.	N-Acetylneuraminic Acid	28-30	alpha-2-macroglobulin	Homo sapiens	96-116
16958607-5	2006	The relative degree of sialic acid linked to fibronectin glycans either by alpha2,3 or alpha2,6 isomeric linkage was estimated by lectin-fibronectin ELISA utilizing lectins from Maackia amurensis and Sambucus nigra, respectively.	N-Acetylneuraminic Acid	23-34	fibronectin 1	Homo sapiens	45-56
16958607-5	2006	The relative degree of sialic acid linked to fibronectin glycans either by alpha2,3 or alpha2,6 isomeric linkage was estimated by lectin-fibronectin ELISA utilizing lectins from Maackia amurensis and Sambucus nigra, respectively.	N-Acetylneuraminic Acid	23-34	fibronectin 1	Homo sapiens	137-148
16958607-7	2006	The glycans of seminal plasma fibronectin, in contrast to blood plasma fibronectin, contained sialic acid more frequently attached by alpha2,3 than by alpha2,6 isomeric linkage.	N-Acetylneuraminic Acid	94-105	fibronectin 1	Homo sapiens	30-41
16557638-5	2006	The diagnostic cross-ring fragments, permitting a distinction between alpha2-3 and alpha2-6 linkages of the sialic acid residues, were seen in abundance.	N-Acetylneuraminic Acid	108-119	immunoglobulin binding protein 1	Homo sapiens	83-91
16719801-5	2006	This active site structure evolved for efficient interaction with charged sialic acid moieties on glycoproteins and stabilization of an oxocarbonium ion in the transition state of the neuraminidase reaction.	N-Acetylneuraminic Acid	74-85	neuraminidase 1	Homo sapiens	184-197
16327992-3	2006	Vibrio cholerae neuraminidase treatment enhanced HBL-2 cell adhesion to galectin-1, suggesting that sialic acid inhibits HBL-2 cell adhesion to galectin-1.	N-Acetylneuraminic Acid	100-111	neuraminidase 1	Homo sapiens	16-29
16327992-3	2006	Vibrio cholerae neuraminidase treatment enhanced HBL-2 cell adhesion to galectin-1, suggesting that sialic acid inhibits HBL-2 cell adhesion to galectin-1.	N-Acetylneuraminic Acid	100-111	galectin 1	Homo sapiens	72-82
16327992-3	2006	Vibrio cholerae neuraminidase treatment enhanced HBL-2 cell adhesion to galectin-1, suggesting that sialic acid inhibits HBL-2 cell adhesion to galectin-1.	N-Acetylneuraminic Acid	100-111	galectin 1	Homo sapiens	144-154
16538641-1	2006	Sialic acid (SA) is responsible for the composition of different isoforms of transferrin and is reported to be a marker of microvascular complications in type 2 diabetes mellitus.	N-Acetylneuraminic Acid	0-11	transferrin	Homo sapiens	77-88
16538641-1	2006	Sialic acid (SA) is responsible for the composition of different isoforms of transferrin and is reported to be a marker of microvascular complications in type 2 diabetes mellitus.	N-Acetylneuraminic Acid	13-15	transferrin	Homo sapiens	77-88
16381065-4	2006	The isomers containing a sialic acid on alpha1-6 or alpha1-3 antennae can be distinguished by MS2 spectral matching, but the alpha2-3 and alpha2-6 linkage types of sialic acid cannot be distinguished by their MS2 spectra.	N-Acetylneuraminic Acid	25-36	adrenoceptor alpha 1D	Homo sapiens	40-60
16381065-4	2006	The isomers containing a sialic acid on alpha1-6 or alpha1-3 antennae can be distinguished by MS2 spectral matching, but the alpha2-3 and alpha2-6 linkage types of sialic acid cannot be distinguished by their MS2 spectra.	N-Acetylneuraminic Acid	164-175	immunoglobulin binding protein 1	Homo sapiens	138-146
16381065-5	2006	However, MS3 spectra derived from fragment ions containing a sialic acid (i.e., C4- and D-type ions) clearly differentiate the alpha2-3 and alpha2-6 linkage types of sialic acid in their MS3 spectral patterns.	N-Acetylneuraminic Acid	61-72	immunoglobulin binding protein 1	Homo sapiens	140-148
16381065-5	2006	However, MS3 spectra derived from fragment ions containing a sialic acid (i.e., C4- and D-type ions) clearly differentiate the alpha2-3 and alpha2-6 linkage types of sialic acid in their MS3 spectral patterns.	N-Acetylneuraminic Acid	166-177	immunoglobulin binding protein 1	Homo sapiens	140-148
16528972-0	2006	Total and lipid-bound plasma sialic acid as diagnostic markers in colorectal cancer patients: correlation with cathepsin B expression in progression to Dukes stage.	N-Acetylneuraminic Acid	29-40	cathepsin B	Homo sapiens	111-122
16274664-1	2005	The most commonly occurring sialic acid, N-acetylneuraminic acid, is the repeating unit in polysialic acid chain of human neuronal cell adhesion molecule as well as in capsular polysialic acid of neuroinvasive bacteria, Escherichia coli K1 and Neisseria meningitidis.	N-Acetylneuraminic Acid	28-39	neuronal cell adhesion molecule	Homo sapiens	122-153
16274664-1	2005	The most commonly occurring sialic acid, N-acetylneuraminic acid, is the repeating unit in polysialic acid chain of human neuronal cell adhesion molecule as well as in capsular polysialic acid of neuroinvasive bacteria, Escherichia coli K1 and Neisseria meningitidis.	N-Acetylneuraminic Acid	41-64	neuronal cell adhesion molecule	Homo sapiens	122-153
16120058-1	2005	Based on BLAST analysis of the human and mouse genome databases using the human CMP sialic acid; alpha2,8-sialyltransferase cDNA (hST8Sia I; EC 2.4.99.8), a putative sialyltransferase gene, was identified on human chromosome 10.	N-Acetylneuraminic Acid	84-95	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	130-139
16120058-7	2005	Detailed substrate specificity analysis of the hST8Sia VI recombinant enzyme in vitro, revealed that this enzyme required the trisaccharide Neu5Acalpha2-3Galbeta1-3GalNAc (where Neu5Ac is N-acetylneuraminic acid and GalNAc is N-acetylgalactosamine) to generate diSia (disialic acid) motifs specifically on O-glycans.	N-Acetylneuraminic Acid	140-146	Oncogene OVC (ovarian adenocarcinoma oncogene)	Homo sapiens	47-51
16120058-7	2005	Detailed substrate specificity analysis of the hST8Sia VI recombinant enzyme in vitro, revealed that this enzyme required the trisaccharide Neu5Acalpha2-3Galbeta1-3GalNAc (where Neu5Ac is N-acetylneuraminic acid and GalNAc is N-acetylgalactosamine) to generate diSia (disialic acid) motifs specifically on O-glycans.	N-Acetylneuraminic Acid	188-211	Oncogene OVC (ovarian adenocarcinoma oncogene)	Homo sapiens	47-51
16079310-8	2005	Sperm treated with neuraminidase to remove sialic acid on DEFB126 before fixation were shown to still possess DEFB126, but lacked the sialic acid component of the glycoprotein.	N-Acetylneuraminic Acid	43-54	DEFB126	Oryctolagus cuniculus	58-65
16289063-4	2005	Based on these studies, coordinated modulation of the sialic acid contents, state of subunit assembly and number of glycans allowed us to generate human or bovine AChE forms which reside in the circulation of mice for long periods of time, mimicking the pharmacokinetic behavior of native serum-derived cholinesterases.	N-Acetylneuraminic Acid	54-65	acetylcholinesterase	Bos taurus	163-167
16339541-4	2005	This protein was cleaved by O-sialoglycoprotein endopeptidase and required sialic acid for E-selectin binding.	N-Acetylneuraminic Acid	75-86	selectin, endothelial cell	Mus musculus	91-101
16170568-1	2005	Lysosomal free sialic acid storage diseases are recessively inherited allelic neurodegenerative disorders that include Salla disease (SD) and infantile sialic acid storage disease (ISSD) caused by mutations in the SLC17A5 gene encoding for a lysosomal membrane protein, sialin, transporting sialic acid from lysosomes.	N-Acetylneuraminic Acid	15-26	solute carrier family 17 member 5	Homo sapiens	214-221
16328467-7	2005	Interestingly, ficolin B specifically recognized sialic acid residues.	N-Acetylneuraminic Acid	49-60	ficolin B	Mus musculus	15-24
16291619-5	2005	Exoglycosidase digestion studies revealed the existence of abundant terminal sialic acid residues in both MUC1 and MUCX.	N-Acetylneuraminic Acid	77-88	mucin 1, cell surface associated	Bos taurus	106-110
16170568-1	2005	Lysosomal free sialic acid storage diseases are recessively inherited allelic neurodegenerative disorders that include Salla disease (SD) and infantile sialic acid storage disease (ISSD) caused by mutations in the SLC17A5 gene encoding for a lysosomal membrane protein, sialin, transporting sialic acid from lysosomes.	N-Acetylneuraminic Acid	15-26	solute carrier family 17 member 5	Homo sapiens	270-276
16170568-1	2005	Lysosomal free sialic acid storage diseases are recessively inherited allelic neurodegenerative disorders that include Salla disease (SD) and infantile sialic acid storage disease (ISSD) caused by mutations in the SLC17A5 gene encoding for a lysosomal membrane protein, sialin, transporting sialic acid from lysosomes.	N-Acetylneuraminic Acid	152-163	solute carrier family 17 member 5	Homo sapiens	214-221
15979923-5	2005	The levels of sugars such as sialic acid, fucose, hexose and hexosamine were increased in SLP and decreased in the BBM following indomethacin treatment, with the effects being maximal 24h after the administration of the drug.	N-Acetylneuraminic Acid	29-40	septin 9	Rattus norvegicus	90-93
16216242-1	2005	Lysosomal sialidase, encoded by neu1, is required for the removal of terminal sialic acid residues from a variety of sialoglycoconjugates.	N-Acetylneuraminic Acid	78-89	neuraminidase 1	Mus musculus	0-19
16216242-1	2005	Lysosomal sialidase, encoded by neu1, is required for the removal of terminal sialic acid residues from a variety of sialoglycoconjugates.	N-Acetylneuraminic Acid	78-89	neuraminidase 1	Mus musculus	32-36
16311888-5	2005	In the "3rd trimester" the amniotic fluid glycoconjugates contained higher relative amounts of glycans terminated by alpha2-6-linked sialic acid (p &lt; 0.00002) and by alpha1-6 innermost fucose (p &lt; 0.000001) than those in the 2nd trimester.	N-Acetylneuraminic Acid	133-144	immunoglobulin binding protein 1	Homo sapiens	117-125
16311888-7	2005	At the perinatal period the relative amount of alpha2-6-linked sialic acid increased (p &lt; 0.03), and it then decreased during delivery (p &lt; 0.02) to the level found in the "3rd trimester" group.	N-Acetylneuraminic Acid	63-74	immunoglobulin binding protein 1	Homo sapiens	47-55
16041604-9	2005	This hybrid technique proved more selective and reliable detection of transferrin isoforms with 2, 3, 4, 5, and 6 sialic acid residues (S(2), S(3), S(4), S(5), and S(6)) in real serum samples.	N-Acetylneuraminic Acid	114-125	transferrin	Homo sapiens	70-81
16158439-5	2005	This region contained 55 genes, including SLC17A5, the gene encoding the lysosomal N-acetylneuraminic acid transport protein.	N-Acetylneuraminic Acid	83-106	solute carrier family 17 member 5	Homo sapiens	42-49
16447769-8	2005	Patients" cells show decreased sialylation status which can be recovered by adding GNE metabolites, such as ManNAc and NeuAc.	N-Acetylneuraminic Acid	119-124	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	83-86
16190615-5	2005	kappa-Casein, glycomacropeptide, and lactoferrin differentially affected cytokine production by DC: kappa-casein significantly inhibited production of TNF-alpha, IL-10, -12, -6, and -1beta, independent of sialic acid, whereas less-marked effects of glycomacropeptide and lactoferrin were seen.	N-Acetylneuraminic Acid	205-216	tumor necrosis factor	Mus musculus	151-160
16550921-2	2005	GNE catalyzes the rate-limiting step in the sialic acid biosynthesis and MNK catalyzes the next step.	N-Acetylneuraminic Acid	44-55	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-3
16550921-9	2005	Patients" fibroblasts and myotubes are hyposialylated and this hyposialylation can be recovered by adding GNE metabolite, ManNAc, or sialic acid per se, NeuAc.	N-Acetylneuraminic Acid	153-158	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	106-109
16177339-3	2005	The adhesins that bind salivary agglutinin glycoprotein (gp340) and human cell surface receptors include the antigen I/II (AgI/II) family polypeptides SspA and SspB and a sialic acid-binding surface protein designated Hsa or GspB.	N-Acetylneuraminic Acid	171-182	deleted in malignant brain tumors 1	Homo sapiens	57-62
16219692-5	2005	This response was abrogated by prior enzymatic cleavage of either sialic acid or GlcNAc residues from the sperm surface and by treatment with a range of pharmacological inhibitors directed against protein kinase A, protein tyrosine kinases and intermediates including Src.	N-Acetylneuraminic Acid	66-77	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	268-271
16177339-6	2005	Adhesion of S. gordonii DL1 cells to gp340 was sialidase sensitive, verifying that Hsa has a major role in mediating sialic acid-specific adhesion to gp340.	N-Acetylneuraminic Acid	117-128	Galactose-specific C-type lectin	Drosophila melanogaster	24-27
16177339-6	2005	Adhesion of S. gordonii DL1 cells to gp340 was sialidase sensitive, verifying that Hsa has a major role in mediating sialic acid-specific adhesion to gp340.	N-Acetylneuraminic Acid	117-128	deleted in malignant brain tumors 1	Homo sapiens	37-42
16177339-6	2005	Adhesion of S. gordonii DL1 cells to gp340 was sialidase sensitive, verifying that Hsa has a major role in mediating sialic acid-specific adhesion to gp340.	N-Acetylneuraminic Acid	117-128	deleted in malignant brain tumors 1	Homo sapiens	150-155
15953602-3	2005	Myelin-associated glycoprotein (MAG), a minor constituent of central and peripheral nervous system myelin, is a member of the Siglec family of sialic acid-binding lectins and binds to gangliosides GD1a and GT1b, prominent molecules on the axon surface.	N-Acetylneuraminic Acid	143-154	myelin-associated glycoprotein	Mus musculus	0-30
16417876-2	2005	Free sialic storage disease is a rare autosomal recessive lysosomal disorder that results from mutations in SLC17A5, a gene that codes for sialin, a lysosomal membrane sialic acid transporting protein.	N-Acetylneuraminic Acid	168-179	solute carrier family 17 member 5	Homo sapiens	108-115
16417876-2	2005	Free sialic storage disease is a rare autosomal recessive lysosomal disorder that results from mutations in SLC17A5, a gene that codes for sialin, a lysosomal membrane sialic acid transporting protein.	N-Acetylneuraminic Acid	168-179	solute carrier family 17 member 5	Homo sapiens	139-145
15939439-6	2005	The mesangial cell proliferation caused by HG, TGF-beta1 and d-threo-PDMP was closely correlated with decreases in both cellular sialic acid contents and ganglioside GM3 synthase activity.	N-Acetylneuraminic Acid	129-140	transforming growth factor, beta 1	Rattus norvegicus	47-56
16137682-2	2005	The key enzyme for the biosynthesis of sialic acid is the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE).	N-Acetylneuraminic Acid	39-50	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	58-120
16137682-2	2005	The key enzyme for the biosynthesis of sialic acid is the UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine-kinase (GNE).	N-Acetylneuraminic Acid	39-50	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	122-125
16137682-3	2005	Mutations in the binding site of the feedback inhibitor CMP-sialic acid of the GNE leads to sialuria, a disease in which patients produce sialic acid in gram scale.	N-Acetylneuraminic Acid	60-71	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	79-82
16137682-3	2005	Mutations in the binding site of the feedback inhibitor CMP-sialic acid of the GNE leads to sialuria, a disease in which patients produce sialic acid in gram scale.	N-Acetylneuraminic Acid	138-149	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	79-82
16137682-5	2005	Expression of the sialuria-mutated GNE leads to a dramatic increase of both cellular sialic acid and polysialic acid on NCAM.	N-Acetylneuraminic Acid	85-96	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	35-38
16014806-6	2005	Moreover, Western blot analysis with lectins specific for alpha(2,3) and alpha(2,6)-linked sialic acids and lectin-binding enzyme-linked immunosorbent assay support a direct effect on TSHR cell-surface expression mediated by sialic acid transfer to the TSHR.	N-Acetylneuraminic Acid	91-102	thyroid stimulating hormone receptor	Homo sapiens	184-188
15953602-3	2005	Myelin-associated glycoprotein (MAG), a minor constituent of central and peripheral nervous system myelin, is a member of the Siglec family of sialic acid-binding lectins and binds to gangliosides GD1a and GT1b, prominent molecules on the axon surface.	N-Acetylneuraminic Acid	143-154	myelin-associated glycoprotein	Mus musculus	32-35
15955740-3	2005	CD22 is a well-characterised B cell restricted siglec that has been shown to mediate both sialic acid-dependent and -independent signaling functions in B cell regulation.	N-Acetylneuraminic Acid	90-101	CD22 molecule	Homo sapiens	0-4
16224972-6	2005	Especially, a considerable degree of variation of the O-acetylation of sialic acid residues could be realized on the glycan structures of O- and N-glycopeptides, whereas EPO-alpha and EPO-beta could be clearly differentiated from NESP solely on the O-glycopeptide level.	N-Acetylneuraminic Acid	71-82	GNAS complex locus	Homo sapiens	230-234
16082330-0	2005	Terminal sialic acid residues on human glycophorin A are recognized by porcine kupffer cells.	N-Acetylneuraminic Acid	9-20	glycophorin A (MNS blood group)	Homo sapiens	39-52
15858075-6	2005	alpha1-Acid glycoprotein (a positive AP protein), alpha1-macroglobulin (a non-AP protein), and alpha1-inhibitor3 (a negative AP protein) also show similar alterations in NeuAc/Gal ratio and decreases in Fuc.	N-Acetylneuraminic Acid	170-175	pregnancy-zone protein	Rattus norvegicus	50-70
15858075-6	2005	alpha1-Acid glycoprotein (a positive AP protein), alpha1-macroglobulin (a non-AP protein), and alpha1-inhibitor3 (a negative AP protein) also show similar alterations in NeuAc/Gal ratio and decreases in Fuc.	N-Acetylneuraminic Acid	170-175	alpha-1-inhibitor III	Rattus norvegicus	95-112
16152730-7	2005	The proportion of acidic mucin rich in sialic acid from the gastric juice of RA patients without the H. pylori infection was significantly lower than those RA patients with H. pylori or the control subjects.	N-Acetylneuraminic Acid	39-50	LOC100508689	Homo sapiens	25-30
16020583-10	2005	Sialic acid was the only inflammatory marker associated with M-IRS.	N-Acetylneuraminic Acid	0-11	isoleucyl-tRNA synthetase 1	Homo sapiens	63-66
15855216-12	2005	The altered kinetic properties of THP in these subjects were strongly associated with increased carbonyl content and with decreased thiol and sialic acid contents.	N-Acetylneuraminic Acid	142-153	uromodulin	Homo sapiens	34-37
16023578-0	2005	Sialin, an anion transporter defective in sialic acid storage diseases, shows highly variable expression in adult mouse brain, and is developmentally regulated.	N-Acetylneuraminic Acid	42-53	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	0-6
16023578-1	2005	Sialin is a lysosomal membrane protein encoded by the SLC17A5 gene, which is mutated in patients with sialic acid storage diseases (SASD).	N-Acetylneuraminic Acid	102-113	solute carrier family 17 member 5	Homo sapiens	0-6
16023578-1	2005	Sialin is a lysosomal membrane protein encoded by the SLC17A5 gene, which is mutated in patients with sialic acid storage diseases (SASD).	N-Acetylneuraminic Acid	102-113	solute carrier family 17 member 5	Homo sapiens	54-61
15989730-1	2005	BACKGROUND: A convenient method for the measurement of sialic acid in plasma apoB-containing lipoproteins is described.	N-Acetylneuraminic Acid	55-66	apolipoprotein B	Homo sapiens	77-81
15989730-4	2005	The contents of sialic acid in apoB were 2.03+/-0.41%, 2.09+/-0.35% (no significance versus normal), 1.86+/-0.27% (P&lt;0.0001), 1.97+/-0.26% (P&lt;0.02), and 2.28+/-0.41% (P&lt;0.002), for normal, all types of hyperlipidaemia, types IIa, IIb, and IV, respectively.	N-Acetylneuraminic Acid	16-27	apolipoprotein B	Homo sapiens	31-35
15989730-5	2005	CONCLUSION: The content of sialic acid in apoB decreased significantly in type IIa but increased in type IV hyperlipidaemia, which may reflect the presence of sialic acid in very low-density lipoprotein apolipoproteins other than apoB.	N-Acetylneuraminic Acid	27-38	apolipoprotein B	Homo sapiens	42-46
15989730-5	2005	CONCLUSION: The content of sialic acid in apoB decreased significantly in type IIa but increased in type IV hyperlipidaemia, which may reflect the presence of sialic acid in very low-density lipoprotein apolipoproteins other than apoB.	N-Acetylneuraminic Acid	27-38	apolipoprotein B	Homo sapiens	230-234
15989730-5	2005	CONCLUSION: The content of sialic acid in apoB decreased significantly in type IIa but increased in type IV hyperlipidaemia, which may reflect the presence of sialic acid in very low-density lipoprotein apolipoproteins other than apoB.	N-Acetylneuraminic Acid	159-170	apolipoprotein B	Homo sapiens	42-46
15989730-5	2005	CONCLUSION: The content of sialic acid in apoB decreased significantly in type IIa but increased in type IV hyperlipidaemia, which may reflect the presence of sialic acid in very low-density lipoprotein apolipoproteins other than apoB.	N-Acetylneuraminic Acid	159-170	apolipoprotein B	Homo sapiens	230-234
16408000-2	2005	Incorporation of a photoactive sialic acid analog into B-cell surface glycoproteins suggests that CD22 molecules may cluster by binding carbohydrate antigens on neighboring CD22 molecules.	N-Acetylneuraminic Acid	31-42	CD22 molecule	Homo sapiens	98-102
16408000-2	2005	Incorporation of a photoactive sialic acid analog into B-cell surface glycoproteins suggests that CD22 molecules may cluster by binding carbohydrate antigens on neighboring CD22 molecules.	N-Acetylneuraminic Acid	31-42	CD22 molecule	Homo sapiens	173-177
16408005-2	2005	As in other members of the sialic acid-binding immunoglobulin-like lectin, or siglec, family, the extracellular N-terminal immunoglobulin domain of CD22 binds to glycan ligands containing sialic acid, which are highly expressed on B-cell glycoproteins.	N-Acetylneuraminic Acid	27-38	CD22 molecule	Homo sapiens	148-152
16408005-2	2005	As in other members of the sialic acid-binding immunoglobulin-like lectin, or siglec, family, the extracellular N-terminal immunoglobulin domain of CD22 binds to glycan ligands containing sialic acid, which are highly expressed on B-cell glycoproteins.	N-Acetylneuraminic Acid	188-199	CD22 molecule	Homo sapiens	148-152
16020660-5	2005	Sequence comparisons, followed by three-dimensional molecular modeling, revealed a region of similarity between p37 and influenza hemagglutinin A, a sialic acid-binding protein that plays a critical role in viral entry.	N-Acetylneuraminic Acid	149-160	nucleoporin 37	Homo sapiens	112-115
16020660-6	2005	Binding of p37 to prostate carcinoma cells was found to be at least partially sialic acid dependent because neuraminidase treatment decreased this binding.	N-Acetylneuraminic Acid	78-89	nucleoporin 37	Homo sapiens	11-14
16020660-6	2005	Binding of p37 to prostate carcinoma cells was found to be at least partially sialic acid dependent because neuraminidase treatment decreased this binding.	N-Acetylneuraminic Acid	78-89	neuraminidase 1	Homo sapiens	108-121
15988320-3	2005	Human serum transferrin contains two biantennary glycans, each consisting of 0 to 4 molecules of sialic acid (SA); its SA content is heterogeneous with high concentration of tetrasialotransferrin (4SA) and low amounts of disialo-, trisialo-, penta-, and hexasialotransferrin.	N-Acetylneuraminic Acid	97-108	transferrin	Homo sapiens	12-23
15988320-3	2005	Human serum transferrin contains two biantennary glycans, each consisting of 0 to 4 molecules of sialic acid (SA); its SA content is heterogeneous with high concentration of tetrasialotransferrin (4SA) and low amounts of disialo-, trisialo-, penta-, and hexasialotransferrin.	N-Acetylneuraminic Acid	110-112	transferrin	Homo sapiens	12-23
15988320-3	2005	Human serum transferrin contains two biantennary glycans, each consisting of 0 to 4 molecules of sialic acid (SA); its SA content is heterogeneous with high concentration of tetrasialotransferrin (4SA) and low amounts of disialo-, trisialo-, penta-, and hexasialotransferrin.	N-Acetylneuraminic Acid	119-121	transferrin	Homo sapiens	12-23
15988320-11	2005	In a sheep model of septic shock secondary to peritonitis, serum free SA was already increased after 15 h. Sepsis is associated with decreased SA content on circulating transferrin and with an increase in blood free SA concentrations.	N-Acetylneuraminic Acid	143-145	transferrin	Homo sapiens	169-180
15988320-11	2005	In a sheep model of septic shock secondary to peritonitis, serum free SA was already increased after 15 h. Sepsis is associated with decreased SA content on circulating transferrin and with an increase in blood free SA concentrations.	N-Acetylneuraminic Acid	143-145	transferrin	Homo sapiens	169-180
15988320-13	2005	Further studies including measurement of blood neuraminidase concentration and activity are needed to understand the process and exact role of SA decrease in septic patients.	N-Acetylneuraminic Acid	143-145	neuraminidase 1	Homo sapiens	47-60
15818560-6	2005	The peak sialic acid content of the IL-4/13 cytokine trap fusion protein was observed to be similar for the control and galactose-fed cultures.	N-Acetylneuraminic Acid	9-20	interleukin-4	Cricetulus griseus	36-40
15608147-3	2005	By contrast, gp340 and SP-A act like mucins in that they provide sialic acid ligands that bind to the viral HA.	N-Acetylneuraminic Acid	65-76	deleted in malignant brain tumors 1	Homo sapiens	13-18
15888312-6	2005	The second, sialic acid synthase, generates either N-acetylneuraminic acid (bacteria) or N-acetylneuraminic acid 9-phosphate (mammals) in a condensation reaction with phosphoenolpyruvate.	N-Acetylneuraminic Acid	51-74	N-acetylneuraminate synthase	Homo sapiens	12-32
15769739-1	2005	Siglec-5 (CD170) is a member of the recently described human CD33-related siglec subgroup of sialic acid binding Ig-like lectins and is expressed on myeloid cells of the hemopoietic system.	N-Acetylneuraminic Acid	93-104	sialic acid binding Ig like lectin 5	Homo sapiens	0-8
15769739-1	2005	Siglec-5 (CD170) is a member of the recently described human CD33-related siglec subgroup of sialic acid binding Ig-like lectins and is expressed on myeloid cells of the hemopoietic system.	N-Acetylneuraminic Acid	93-104	sialic acid binding Ig like lectin 5	Homo sapiens	10-15
15769739-1	2005	Siglec-5 (CD170) is a member of the recently described human CD33-related siglec subgroup of sialic acid binding Ig-like lectins and is expressed on myeloid cells of the hemopoietic system.	N-Acetylneuraminic Acid	93-104	CD33 molecule	Homo sapiens	61-65
15797139-2	2005	The lactonization could result from the C-2 carboxylic acid of the nonreducing residue condensing with the hydroxyl group or/and sulfated group at C-9 of the reducing residue to form a six-membered ring between two adjacent sialic acid residues.	N-Acetylneuraminic Acid	224-235	complement C9	Homo sapiens	147-150
15608147-3	2005	By contrast, gp340 and SP-A act like mucins in that they provide sialic acid ligands that bind to the viral HA.	N-Acetylneuraminic Acid	65-76	surfactant protein A1	Homo sapiens	23-27
15844985-2	2005	Glucose, galactose, and N-acetylneuraminic acid were covalently coupled to 3-morphorlinosydnonimine (SIN-1), a mesoionic heterocyclic NO donor, via a carbamate linkage at the anomeric position.	N-Acetylneuraminic Acid	24-47	MAPK associated protein 1	Homo sapiens	101-106
15866060-0	2005	Levels of plasma total adrenomedullin are related with two acute phase inflammatory reactants (fibrinogen and sialic acid) but not with markers of endothelial dysfunction in Type 1 diabetes Adrenomedullin and vascular risk factors in Type 1 DM.	N-Acetylneuraminic Acid	110-121	adrenomedullin	Homo sapiens	23-37
15866060-6	2005	In the diabetic group, AM levels correlated significantly with sialic acid (r=.16; P&lt;.05), but a more significant correlation was found with fibrinogen (r=.30; P&lt;.001).	N-Acetylneuraminic Acid	63-74	adrenomedullin	Homo sapiens	23-25
15897188-0	2005	Structure-guided saturation mutagenesis of N-acetylneuraminic acid lyase for the synthesis of sialic acid mimetics.	N-Acetylneuraminic Acid	94-105	N-acetylneuraminate pyruvate lyase	Homo sapiens	43-72
15897188-2	2005	Sialic acid analogues are, however, difficult to synthesize by traditional chemical methods and the enzyme N-acetylneuraminic acid lyase (NAL) has previously been used for the synthesis of a number of analogues.	N-Acetylneuraminic Acid	0-11	N-acetylneuraminate pyruvate lyase	Homo sapiens	107-136
15897188-2	2005	Sialic acid analogues are, however, difficult to synthesize by traditional chemical methods and the enzyme N-acetylneuraminic acid lyase (NAL) has previously been used for the synthesis of a number of analogues.	N-Acetylneuraminic Acid	0-11	N-acetylneuraminate pyruvate lyase	Homo sapiens	138-141
15897188-8	2005	These engineering efforts provide a scaffold for the further tailoring of NAL for the synthesis of sialic acid mimetics.	N-Acetylneuraminic Acid	99-110	N-acetylneuraminate pyruvate lyase	Homo sapiens	74-77
15701648-3	2005	MAG, a member of the Siglec family of sialic acid-binding lectins, binds to sialoglycoconjugates on axons and particularly to gangliosides GD1a and GT1b, which may mediate some of the inhibitory effects of MAG.	N-Acetylneuraminic Acid	38-49	myelin-associated glycoprotein	Rattus norvegicus	0-3
15722044-6	2005	The existence of N-acetylneuraminic acid (sialic acid) in insulin receptor and in the antigenic determinant of IgG suggests that such an acid may develop specific interactions usable in affinity chromatography.	N-Acetylneuraminic Acid	17-40	insulin receptor	Mus musculus	58-74
15722044-6	2005	The existence of N-acetylneuraminic acid (sialic acid) in insulin receptor and in the antigenic determinant of IgG suggests that such an acid may develop specific interactions usable in affinity chromatography.	N-Acetylneuraminic Acid	42-53	insulin receptor	Mus musculus	58-74
15748884-1	2005	The bifunctional enzyme UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE) is essential for early embryonic development and catalyzes the rate limiting step in sialic acid biosynthesis.	N-Acetylneuraminic Acid	178-189	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	88-91
15748884-9	2005	This subcellular localization of GNE is in good agreement with its established role as the key enzyme of sialic acid biosynthesis, since the sialylation of glycoconjugates takes place in the Golgi complex.	N-Acetylneuraminic Acid	105-116	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	33-36
15670773-1	2005	Hereditary inclusion body myopathy (HIBM) is a unique group of neuromuscular disorders characterized by adult-onset, slowly progressive distal and proximal muscle weakness, which is caused by mutations in UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE), the key enzyme in the biosynthetic pathway of sialic acid.	N-Acetylneuraminic Acid	321-332	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	205-267
15784568-7	2005	Many gp340 interactions were sialidase sensitive, and each of the interaction modes (I to III) for S. gordonii was correlated with a variant of sialic acid specificity.	N-Acetylneuraminic Acid	144-155	deleted in malignant brain tumors 1	Homo sapiens	5-10
15784568-8	2005	Adherence of S. gordonii DL1 (Challis) to surface-bound gp340 was dependent upon expression of the sialic acid binding adhesin Hsa.	N-Acetylneuraminic Acid	99-110	deleted in malignant brain tumors 1	Homo sapiens	56-61
15576633-4	2005	In contrast, hOAT4 synthesized in mutant CHO-Lec cells, carrying different structural forms of sugar moieties (mannose-rich in Lec1 cells, sialic acid-deficient in Lec2 cells, and sialic acid/galactose-deficient in Lec8 cells) were able to traffic to the cell surface.	N-Acetylneuraminic Acid	139-150	solute carrier family 22 member 11	Homo sapiens	13-18
15770530-2	2005	Sialyl-Tn is synthesized by a CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase: ST6GalNAc I, which catalyzes the transfer of a sialic acid residue in alpha2,6-linkage to the GalNAcalpha1-O-Ser/Thr structure.	N-Acetylneuraminic Acid	124-135	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	Homo sapiens	77-88
16133834-4	2005	Total ST activity measured on asialofetuin, employing a CMP fluorescent sialic acid, varied among the pancreatic cell lines and could be correlated to the expression of their cell surface antigens.	N-Acetylneuraminic Acid	72-83	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	6-8
15576633-4	2005	In contrast, hOAT4 synthesized in mutant CHO-Lec cells, carrying different structural forms of sugar moieties (mannose-rich in Lec1 cells, sialic acid-deficient in Lec2 cells, and sialic acid/galactose-deficient in Lec8 cells) were able to traffic to the cell surface.	N-Acetylneuraminic Acid	180-191	solute carrier family 22 member 11	Homo sapiens	13-18
15668924-5	2005	Furthermore, analysis of the sialic acid links alpha(2,3)Gal/GalNAc and alpha(2,6)Gal/GalNAc in immunoprecipitated CD43 and CD45 molecules confirm that age alters the glycosylation of specific proteins that regulate TCR interaction with antigen presenting cells.	N-Acetylneuraminic Acid	29-40	sialophorin	Mus musculus	115-119
15563466-2	2005	Previous studies demonstrated sialic acid-dependent binding of Siglec-8 but failed to reveal significant substructure specificity or high affinity of that binding.	N-Acetylneuraminic Acid	30-41	sialic acid binding Ig like lectin 8	Homo sapiens	63-71
15668924-5	2005	Furthermore, analysis of the sialic acid links alpha(2,3)Gal/GalNAc and alpha(2,6)Gal/GalNAc in immunoprecipitated CD43 and CD45 molecules confirm that age alters the glycosylation of specific proteins that regulate TCR interaction with antigen presenting cells.	N-Acetylneuraminic Acid	29-40	T cell receptor alpha variable 6-3	Mus musculus	216-219
15801324-5	2005	The MN system codifies for glycophorin A, a sialoglycoprotein that represents a major ligand for several bacteria and viruses that recognize the N-acetylneuraminic acid present in this protein.	N-Acetylneuraminic Acid	145-168	glycophorin A (MNS blood group)	Homo sapiens	27-40
15611266-7	2005	Sialic acid is known to inhibit alternative complement pathway activation, and, as expected, the bactericidal index (percentage of bacteria killed) for individual strains was inversely proportional to the sialic acid content of the CPS, and L-ficolin-initiated opsonophagocytic killing was significantly increased by addition of CPS-specific IgG2, which increased activation of the alternative pathway.	N-Acetylneuraminic Acid	0-11	ficolin 2	Homo sapiens	241-250
15516337-8	2005	From the biochemical phenotype of the diseases and the predicted polytopic structure of the protein, it has been suggested that sialin functions as a lysosomal sialic acid transporter.	N-Acetylneuraminic Acid	160-171	solute carrier family 17 member 5	Homo sapiens	128-134
15516337-9	2005	Here we directly demonstrate that this activity is mediated by sialin and that the recombinant protein has functional characteristics similar to the native lysosomal sialic acid transport system.	N-Acetylneuraminic Acid	166-177	solute carrier family 17 member 5	Homo sapiens	63-69
15597323-0	2005	Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling.	N-Acetylneuraminic Acid	68-79	CD33 molecule	Homo sapiens	35-39
15597323-1	2005	Human CD33 is a myeloid-restricted transmembrane protein of the sialic acid-binding Ig-like lectin (Siglec) family.	N-Acetylneuraminic Acid	64-75	CD33 molecule	Homo sapiens	6-10
15597323-5	2005	Similarly, sialic acid (CD33 ligand) removal from the monocyte surface by neuraminidase resulted in IL-1 beta up-regulation, while the addition of red blood cells or sialyllactosamine (but not lactosamine) reversed the effect of neuraminidase treatment, thus demonstrating the importance of ligand recognition by CD33 for repression of monocyte activation.	N-Acetylneuraminic Acid	11-22	CD33 molecule	Homo sapiens	24-28
15597323-5	2005	Similarly, sialic acid (CD33 ligand) removal from the monocyte surface by neuraminidase resulted in IL-1 beta up-regulation, while the addition of red blood cells or sialyllactosamine (but not lactosamine) reversed the effect of neuraminidase treatment, thus demonstrating the importance of ligand recognition by CD33 for repression of monocyte activation.	N-Acetylneuraminic Acid	11-22	neuraminidase 1	Homo sapiens	74-87
15597323-5	2005	Similarly, sialic acid (CD33 ligand) removal from the monocyte surface by neuraminidase resulted in IL-1 beta up-regulation, while the addition of red blood cells or sialyllactosamine (but not lactosamine) reversed the effect of neuraminidase treatment, thus demonstrating the importance of ligand recognition by CD33 for repression of monocyte activation.	N-Acetylneuraminic Acid	11-22	interleukin 1 beta	Homo sapiens	100-109
15597323-5	2005	Similarly, sialic acid (CD33 ligand) removal from the monocyte surface by neuraminidase resulted in IL-1 beta up-regulation, while the addition of red blood cells or sialyllactosamine (but not lactosamine) reversed the effect of neuraminidase treatment, thus demonstrating the importance of ligand recognition by CD33 for repression of monocyte activation.	N-Acetylneuraminic Acid	11-22	neuraminidase 1	Homo sapiens	229-242
15597323-5	2005	Similarly, sialic acid (CD33 ligand) removal from the monocyte surface by neuraminidase resulted in IL-1 beta up-regulation, while the addition of red blood cells or sialyllactosamine (but not lactosamine) reversed the effect of neuraminidase treatment, thus demonstrating the importance of ligand recognition by CD33 for repression of monocyte activation.	N-Acetylneuraminic Acid	11-22	CD33 molecule	Homo sapiens	313-317
15597323-8	2005	These data indicate that by controlling monocyte activation, CD33 is a key molecule in the inflammatory response, depending on the sialic acid microenvironment for its repressor activity.	N-Acetylneuraminic Acid	131-142	CD33 molecule	Homo sapiens	61-65
16233760-3	2005	Moreover, AGP added to medium was found to maintain the number of viable hepatocytes for as long as 6 d. The hepatoprotective effect of AGP was lost by removing sialic acid groups at the N-glycan chain terminal of AGP.	N-Acetylneuraminic Acid	161-172	orosomucoid 1	Rattus norvegicus	10-13
16233760-3	2005	Moreover, AGP added to medium was found to maintain the number of viable hepatocytes for as long as 6 d. The hepatoprotective effect of AGP was lost by removing sialic acid groups at the N-glycan chain terminal of AGP.	N-Acetylneuraminic Acid	161-172	orosomucoid 1	Rattus norvegicus	136-139
16233760-3	2005	Moreover, AGP added to medium was found to maintain the number of viable hepatocytes for as long as 6 d. The hepatoprotective effect of AGP was lost by removing sialic acid groups at the N-glycan chain terminal of AGP.	N-Acetylneuraminic Acid	161-172	orosomucoid 1	Rattus norvegicus	136-139
15903240-1	2005	When sodium butyrate (NaBu) was added to serum-free suspension culture of recombinant CHO (rCHO) cells for enhanced expression of human thrombopoietin (hTPO), apoptotic cell death of rCHO cells was induced in a dose-dependent manner and hTPO quality was deteriorated in regard to sialic acid and acidic isoform contents.	N-Acetylneuraminic Acid	280-291	thrombopoietin	Homo sapiens	136-150
15520251-1	2005	The anticancer drug rViscumin, currently under clinical development, has been shown in previous studies to be a sialic acid specific ribosome inactivating protein (RIP).	N-Acetylneuraminic Acid	112-123	receptor interacting serine/threonine kinase 1	Homo sapiens	133-162
15520251-1	2005	The anticancer drug rViscumin, currently under clinical development, has been shown in previous studies to be a sialic acid specific ribosome inactivating protein (RIP).	N-Acetylneuraminic Acid	112-123	receptor interacting serine/threonine kinase 1	Homo sapiens	164-167
16094462-1	2005	The microheterogeneity property of hCG with regards to its sialic acid contents resulted in variable mobility of the glycoprotein in SDS-PAGE.	N-Acetylneuraminic Acid	59-70	chorionic gonadotropin subunit beta 5	Homo sapiens	35-38
15613339-5	2005	Infection of ciliated cells by rgPIV3 was sensitive to a neuraminidase specific for alpha2-6-linked sialic acid residues, but not to a neuraminidase that cleaves alpha2-3- and alpha2-8-linked sialic acid residues.	N-Acetylneuraminic Acid	100-111	immunoglobulin binding protein 1	Homo sapiens	84-92
16319516-1	2005	OBJECTIVES: The aim of the present study was to investigate the activity of CMP-NeuAc:Galbeta(1,4)GlcNAc sialyltransferase (ST6Gal I) in colorectal cancer (CRC).	N-Acetylneuraminic Acid	80-85	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	124-132
15613339-6	2005	This provided evidence that rgPIV3 utilizes alpha2-6-linked sialic acid residues for initiating infection, a specificity also described for human influenza viruses.	N-Acetylneuraminic Acid	60-71	immunoglobulin binding protein 1	Homo sapiens	44-52
15999150-0	2005	Influence of sialic acid removal on MUC1 antigenic reactivity in head and neck carcinoma.	N-Acetylneuraminic Acid	13-24	mucin 1, cell surface associated	Homo sapiens	36-40
15557178-1	2004	Siglec-7 and Siglec-9 are two members of the recently characterized CD33-related Siglec family of sialic acid binding proteins and are both expressed on human monocytes and NK cells.	N-Acetylneuraminic Acid	98-109	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
15330759-0	2004	Domain-specific characteristics of the bifunctional key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.	N-Acetylneuraminic Acid	66-77	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	92-154
15330759-1	2004	UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase is a bifunctional enzyme, which initiates and regulates sialic acid biosynthesis.	N-Acetylneuraminic Acid	119-130	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	0-62
15557178-1	2004	Siglec-7 and Siglec-9 are two members of the recently characterized CD33-related Siglec family of sialic acid binding proteins and are both expressed on human monocytes and NK cells.	N-Acetylneuraminic Acid	98-109	sialic acid binding Ig like lectin 9	Homo sapiens	13-21
15557178-1	2004	Siglec-7 and Siglec-9 are two members of the recently characterized CD33-related Siglec family of sialic acid binding proteins and are both expressed on human monocytes and NK cells.	N-Acetylneuraminic Acid	98-109	CD33 molecule	Homo sapiens	68-72
15557178-7	2004	Finally, mutation of the membrane-proximal motif increased the sialic acid binding activity of Siglecs-7 and -9, raising the possibility that "inside-out" signaling may occur to regulate ligand binding.	N-Acetylneuraminic Acid	63-74	sialic acid binding Ig like lectin 7	Homo sapiens	95-111
15380219-4	2004	It has been demonstrated in vitro that trans-sialidase possesses the ability of transferring Neu5Ac residue to acceptor (asialofetuin) both from alpha2-3- (GM1, GM3, GD1a), and alpha2-8-sialylated gangliosides (GD3 and GD1b, but not GT1b and GQ1b).	N-Acetylneuraminic Acid	93-99	immunoglobulin binding protein 1	Homo sapiens	177-185
15488769-1	2004	Sialoadhesin is a sialic acid-binding immunoglobulin-like lectin (Siglec), expressed on subsets of macrophages.	N-Acetylneuraminic Acid	18-29	sialic acid binding Ig like lectin 1	Homo sapiens	0-12
15488769-3	2004	The N-terminal sialoadhesin domain can mediate sialic acid-binding on its own.	N-Acetylneuraminic Acid	47-58	sialic acid binding Ig like lectin 1	Homo sapiens	15-27
15510212-2	2004	Sialic acids cleaved off from degraded sialoglycoconjugates are exported from lysosomes by a membrane transporter, named sialin, which is defective in two allelic inherited diseases: infantile sialic acid storage disease (ISSD) and Salla disease.	N-Acetylneuraminic Acid	193-204	solute carrier family 17 member 5	Homo sapiens	121-127
15510212-7	2004	Since neurological symptoms predominate in Salla disease, our results suggest that sialin is rate-limiting to specific sialic acid-dependent processes of the nervous system.	N-Acetylneuraminic Acid	119-130	solute carrier family 17 member 5	Homo sapiens	83-89
15592774-10	2004	Thus, sialic acid, a component of mucin, may play a key role in the dry eye condition.	N-Acetylneuraminic Acid	6-17	LOC100508689	Homo sapiens	34-39
15555448-2	2004	METHODS: Neuraminidase (NMD) was used to digest the sialic acid at terminals of sugar chains of MA-CEA, and then the datura stramonium agglutinin (DSA) and anti-CEA antibody were used to set up streptavidin-biotin complex (ABC) system EIA (ABC-EIA) for detecting serum MA-CEA levels of 239 patients with carcinomas of lung, stomach, liver, colon and ovary.	N-Acetylneuraminic Acid	52-63	CEA cell adhesion molecule 3	Homo sapiens	99-102
15316006-0	2004	The sialic acid component of the beta1 subunit modulates voltage-gated sodium channel function.	N-Acetylneuraminic Acid	4-15	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	33-38
15380219-6	2004	Two methods were used to reveal whether alpha2-8 bond can be formed between Neu5Ac residues during trans-sialylation, that is immunochemical detection using monoclonal antibodies specific to alpha2-8 di- and oligosialic acids, and fluorometric C7/C9 analysis.	N-Acetylneuraminic Acid	76-82	immunoglobulin binding protein 1	Homo sapiens	40-48
15380219-6	2004	Two methods were used to reveal whether alpha2-8 bond can be formed between Neu5Ac residues during trans-sialylation, that is immunochemical detection using monoclonal antibodies specific to alpha2-8 di- and oligosialic acids, and fluorometric C7/C9 analysis.	N-Acetylneuraminic Acid	76-82	immunoglobulin binding protein 1	Homo sapiens	191-199
15372694-2	2004	We have designed and synthesized two new lanthanide ion ligands (L1 and L2) that are capable of molecular recognition of sialic acid residues.	N-Acetylneuraminic Acid	121-132	ribosomal protein L4	Rattus norvegicus	65-74
15292262-8	2004	Like all siglecs, Siglec-7 and -9 recognize sialic acid-containing glycans of glycoproteins and glycolipids as ligands.	N-Acetylneuraminic Acid	44-55	sialic acid binding Ig like lectin 7	Homo sapiens	18-33
15242781-6	2004	Here, we describe the selective cell-based in vitro inhibition of ST8SiaII using synthetic sialic acid precursors.	N-Acetylneuraminic Acid	91-102	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	66-74
15289269-1	2004	Anti-disialoside antibodies (Abs) that bind NeuAc(alpha2-8) NeuAc epitopes on GQ1b and related gangliosides are found in human autoimmune neuropathy sera and are considered to be pathogenic.	N-Acetylneuraminic Acid	44-49	immunoglobulin binding protein 1	Homo sapiens	50-58
15289269-1	2004	Anti-disialoside antibodies (Abs) that bind NeuAc(alpha2-8) NeuAc epitopes on GQ1b and related gangliosides are found in human autoimmune neuropathy sera and are considered to be pathogenic.	N-Acetylneuraminic Acid	60-65	immunoglobulin binding protein 1	Homo sapiens	50-58
15175257-3	2004	MAG, a member of the Siglec family of sialic acid-binding lectins, binds specifically to gangliosides GD1a and GT1b, which are the major sialoglycoconjugates on mammalian axons.	N-Acetylneuraminic Acid	38-49	myelin associated glycoprotein	Homo sapiens	0-3
15496590-3	2004	Here we have cloned a cDNA encoding the sialyltransferase, designated rtST6GalNAc, responsible for the transfer of the first sialic acid residue onto the O-glycan chain of PSGP.	N-Acetylneuraminic Acid	125-136	GalNAc alpha 2,6-sialyltransferase	Oncorhynchus mykiss	70-81
15044396-5	2004	However, we found the sialic acid alpha2-3 galactose linkage as an additional terminal carbohydrate structure on seminal fluid PSA.	N-Acetylneuraminic Acid	22-33	kallikrein related peptidase 3	Homo sapiens	127-130
15496590-3	2004	Here we have cloned a cDNA encoding the sialyltransferase, designated rtST6GalNAc, responsible for the transfer of the first sialic acid residue onto the O-glycan chain of PSGP.	N-Acetylneuraminic Acid	125-136	polysialoglycoprotein	Oncorhynchus mykiss	172-176
15760064-7	2004	The adsorption of type III mucin (1% sialic acid content) was interpreted using Freundlich or Langmuir adsorption isotherms.	N-Acetylneuraminic Acid	37-48	solute carrier family 13 member 2	Rattus norvegicus	27-32
15254181-3	2004	In rodents and humans, sialoadhesin, or Siglec-1, has been described as a macrophage-restricted molecule and to specifically bind sialic acid moieties.	N-Acetylneuraminic Acid	130-141	sialic acid binding Ig like lectin 1	Homo sapiens	23-35
15254181-3	2004	In rodents and humans, sialoadhesin, or Siglec-1, has been described as a macrophage-restricted molecule and to specifically bind sialic acid moieties.	N-Acetylneuraminic Acid	130-141	sialic acid binding Ig like lectin 1	Homo sapiens	40-48
15254884-9	2004	Sialic acid was the acute-phase response marker with the highest DR (3.16), and showed stronger correlations with other inflammatory markers, including C-reactive protein (CRP), than IL-6.	N-Acetylneuraminic Acid	0-11	C-reactive protein	Homo sapiens	152-170
15197734-8	2004	The results suggest that N- and O-linked glycans with sialic acid are attached to cystatin C.	N-Acetylneuraminic Acid	54-65	cystatin C	Rattus norvegicus	82-92
23105458-9	2004	The changes in serum proteins with terminal alpha-2-6 sialic acid correlated well with alterations in the levels of sialic acid forms and sialyltransferase.	N-Acetylneuraminic Acid	54-65	immunoglobulin binding protein 1	Homo sapiens	44-53
23105458-9	2004	The changes in serum proteins with terminal alpha-2-6 sialic acid correlated well with alterations in the levels of sialic acid forms and sialyltransferase.	N-Acetylneuraminic Acid	116-127	immunoglobulin binding protein 1	Homo sapiens	44-53
15254884-9	2004	Sialic acid was the acute-phase response marker with the highest DR (3.16), and showed stronger correlations with other inflammatory markers, including C-reactive protein (CRP), than IL-6.	N-Acetylneuraminic Acid	0-11	C-reactive protein	Homo sapiens	172-175
15147877-1	2004	Hereditary inclusion body myopathy (HIBM) is a neuromuscular disorder, caused by mutations in UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, the key enzyme of sialic acid biosynthesis.	N-Acetylneuraminic Acid	176-187	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	94-156
15196944-4	2004	In this study, we have demonstrated that the downregulation of Bcl-2 by overexpression of CMP-NeuAc:GM3 alpha-2,8-sialyltransferase (GD3 synthase) results in an accelerated apoptosis in vascular endothelial cells (ECV304), as evidenced by DNA fragmentation and caspase-3 activation.	N-Acetylneuraminic Acid	94-99	BCL2 apoptosis regulator	Homo sapiens	63-68
15196944-4	2004	In this study, we have demonstrated that the downregulation of Bcl-2 by overexpression of CMP-NeuAc:GM3 alpha-2,8-sialyltransferase (GD3 synthase) results in an accelerated apoptosis in vascular endothelial cells (ECV304), as evidenced by DNA fragmentation and caspase-3 activation.	N-Acetylneuraminic Acid	94-99	GRDX	Homo sapiens	133-136
15196944-4	2004	In this study, we have demonstrated that the downregulation of Bcl-2 by overexpression of CMP-NeuAc:GM3 alpha-2,8-sialyltransferase (GD3 synthase) results in an accelerated apoptosis in vascular endothelial cells (ECV304), as evidenced by DNA fragmentation and caspase-3 activation.	N-Acetylneuraminic Acid	94-99	caspase 3	Homo sapiens	261-270
15187099-1	2004	We have used HSCA-2, an mAb that recognizes a sialic acid-dependent epitope on the low molecular mass (approximately 115-kDa) glycoform of CD43 that is expressed in resting T and NK cells, to examine the expression characteristics and stimulatory functions of CD43 in human CD4+ memory T cells.	N-Acetylneuraminic Acid	46-57	sialophorin	Homo sapiens	139-143
15187099-1	2004	We have used HSCA-2, an mAb that recognizes a sialic acid-dependent epitope on the low molecular mass (approximately 115-kDa) glycoform of CD43 that is expressed in resting T and NK cells, to examine the expression characteristics and stimulatory functions of CD43 in human CD4+ memory T cells.	N-Acetylneuraminic Acid	46-57	CD4 molecule	Homo sapiens	139-142
14672916-6	2004	Enzymatic modification of the SA-linkages present on pSP-D demonstrates that the type of SA-linkage is important for its hemagglutination-inhibitory activity, and correlates with receptor-binding specificity of the IAV strains.	N-Acetylneuraminic Acid	30-32	surfactant protein D	Homo sapiens	53-58
14672916-6	2004	Enzymatic modification of the SA-linkages present on pSP-D demonstrates that the type of SA-linkage is important for its hemagglutination-inhibitory activity, and correlates with receptor-binding specificity of the IAV strains.	N-Acetylneuraminic Acid	89-91	surfactant protein D	Homo sapiens	53-58
15241723-2	2004	CBG contains six sites for N-glycosylation with, on average, five sites occupied by a mixture of biantennary and triantennary oligosaccharides with variable additional terminal sialic acid residues leading to glycoforms with significant heterogeneity in mass and isoelectric points.	N-Acetylneuraminic Acid	177-188	serpin family A member 6	Homo sapiens	0-3
15238070-5	2004	Most self-components are protected with sialic acid or galactose that disrupt the pattern of the sugars that MBL can bind, but MBL may be significantly involved in the elimination of self-components that have lost these protective terminal residues.	N-Acetylneuraminic Acid	40-51	mannose binding lectin 2	Homo sapiens	109-112
15172001-2	2004	This gene codes for sialin, a lysosomal membrane protein that transports the charged sugar, N-acetylneuraminic acid (sialic acid), out of lysosomes.	N-Acetylneuraminic Acid	92-115	solute carrier family 17 member 5	Homo sapiens	20-26
15172001-2	2004	This gene codes for sialin, a lysosomal membrane protein that transports the charged sugar, N-acetylneuraminic acid (sialic acid), out of lysosomes.	N-Acetylneuraminic Acid	117-128	solute carrier family 17 member 5	Homo sapiens	20-26
15172001-10	2004	This child"s clinical manifestations of a lysosomal free sialic acid storage disease are consistent with her sialin mutations and biochemical findings.	N-Acetylneuraminic Acid	57-68	solute carrier family 17 member 5	Homo sapiens	109-115
15172005-0	2004	A novel mutation in the SLC17A5 gene causing both severe and mild phenotypes of free sialic acid storage disease in one inbred Bedouin kindred.	N-Acetylneuraminic Acid	85-96	solute carrier family 17 member 5	Homo sapiens	24-31
14748740-4	2004	In the present study, we show that the 145 kDa form of GC-C contains sialic acid and galactose residues and is present on the PM (plasma membrane) of cells, whereas the 130 kDa form is a high mannose form that is resident in the endoplasmic reticulum and serves as the precursor for the PM-associated form.	N-Acetylneuraminic Acid	69-80	natriuretic peptide receptor 3	Homo sapiens	55-59
15176893-1	2004	Using capillary electrophoresis coupled to laser-induced fluorescence (HPCE-LIF), it was possible to profile N-linked oligosaccharides from EPO, including species containing sialic acid, during the course of batch cultures performed either in serum-free or serum-containing medium.	N-Acetylneuraminic Acid	174-185	leukemia inhibitory factor	Mus musculus	76-79
15039074-3	2004	HN plays central roles in PoRV infection; i.e., it recognizes sialic acid-containing cell receptors that mediate virus attachment and penetration; in addition, its neuraminidase (sialic acid hydrolysis) activity has been proposed to be a virulence factor.	N-Acetylneuraminic Acid	179-190	neuraminidase 1	Homo sapiens	164-177
14736726-9	2004	We found some novel carbohydrate chains containing both N-acetylneuraminic acid and N-glycolylneuraminic acid in bovine AGP.	N-Acetylneuraminic Acid	56-79	alpha-1-acid glycoprotein	Bos taurus	120-123
15086888-1	2004	Immunoglobulin A nephropathy (IgAN) patients exhibit circulating IgA1 with reduced galactose (Gal) and/or sialic acid (Neu5Ac) and increased exposure of N-acetylgalactosamine (GalNAc).	N-Acetylneuraminic Acid	106-117	IGAN1	Homo sapiens	30-34
15086888-1	2004	Immunoglobulin A nephropathy (IgAN) patients exhibit circulating IgA1 with reduced galactose (Gal) and/or sialic acid (Neu5Ac) and increased exposure of N-acetylgalactosamine (GalNAc).	N-Acetylneuraminic Acid	106-117	immunoglobulin heavy constant alpha 1	Homo sapiens	65-69
15086888-1	2004	Immunoglobulin A nephropathy (IgAN) patients exhibit circulating IgA1 with reduced galactose (Gal) and/or sialic acid (Neu5Ac) and increased exposure of N-acetylgalactosamine (GalNAc).	N-Acetylneuraminic Acid	119-125	IGAN1	Homo sapiens	30-34
15086888-1	2004	Immunoglobulin A nephropathy (IgAN) patients exhibit circulating IgA1 with reduced galactose (Gal) and/or sialic acid (Neu5Ac) and increased exposure of N-acetylgalactosamine (GalNAc).	N-Acetylneuraminic Acid	119-125	immunoglobulin heavy constant alpha 1	Homo sapiens	65-69
15056214-3	2004	The brucellae adhered to epithelial cells forming localized bacterial microcolonies on the cell surface, and this process was inhibited significantly by pretreatment of epithelial cells with neuraminidase and sodium periodate and by preincubation of the bacteria with heparan sulphate and N-acetylneuraminic acid.	N-Acetylneuraminic Acid	289-312	neuraminidase 1	Homo sapiens	191-204
15056214-5	2004	Notably, the brucellae also adhered to cultured THP-1 cells, and this event was greatly reduced upon removal of sialic acid residues from these cells with neuraminidase.	N-Acetylneuraminic Acid	112-123	neuraminidase 1	Homo sapiens	155-168
15279066-6	2004	Incorporated NeuGc-GM3 seemed to be converted to NeuAc-NeuGc-type GD3, and then to NeuAc-NeuGc-type GD2 with alpha2,8-sialyltransferase and beta1,4-GalNAc transferase, respectively.	N-Acetylneuraminic Acid	49-54	GRDX	Homo sapiens	66-69
14767580-5	2004	A longer, 6-day action of the inhibitor induced a decrease in sialic acid and T antigen levels in cellular MUC1 mucin.	N-Acetylneuraminic Acid	62-73	mucin 1, cell surface associated	Homo sapiens	107-111
14966124-2	2004	In this work, we explore the structure-activity relationship of Man-NAc analogs on cell viability and metabolic flux into the sialic acid biosynthetic pathway to gain a better understanding of the fundamental biology underlying "glycosylation engineering" technology.	N-Acetylneuraminic Acid	126-137	synuclein alpha	Homo sapiens	68-71
15048729-1	2004	Murine (m) Siglec-E and mSiglec-F are recently discovered murine sialic acid-binding Ig-like lectins with tyrosine-based inhibitory signaling motifs.	N-Acetylneuraminic Acid	65-76	sialic acid binding Ig-like lectin E	Mus musculus	11-19
15048729-1	2004	Murine (m) Siglec-E and mSiglec-F are recently discovered murine sialic acid-binding Ig-like lectins with tyrosine-based inhibitory signaling motifs.	N-Acetylneuraminic Acid	65-76	sialic acid binding Ig-like lectin F	Mus musculus	24-33
15835705-4	2004	In this paper two fluorescent methods are described that permit quantitative measurement of sialidase/neuraminidase activity toward indoxyl-derivatized N-acetyl-neuraminic acid substrates.	N-Acetylneuraminic Acid	152-176	neuraminidase 1	Homo sapiens	102-115
15022221-0	2004	Site-specific introduction of sialic acid into insulin.	N-Acetylneuraminic Acid	30-41	insulin	Homo sapiens	47-54
14693915-7	2004	We conclude that Neu5Ac-binding ability of at least some human CD33rSiglecs is a derived state selected for following loss of Neu5Gc in the hominid lineage.	N-Acetylneuraminic Acid	17-23	CD33 molecule	Homo sapiens	63-67
22900334-7	2004	This inhibition gives a hint to binding with Galbeta1-3GalNAc or Galbeta1-4GlcNAc residue containing sialic acid at the terminal position with alpha 2-6 or alpha 2-3 linkage.	N-Acetylneuraminic Acid	101-112	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	143-152
22900334-7	2004	This inhibition gives a hint to binding with Galbeta1-3GalNAc or Galbeta1-4GlcNAc residue containing sialic acid at the terminal position with alpha 2-6 or alpha 2-3 linkage.	N-Acetylneuraminic Acid	101-112	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	156-165
15481156-6	2004	Peritubular myoid cells in the undescended testis only reacted with PNA, after neuraminidase digestion, thus revealing the presence of D-galactose (beta1--&gt;3)-N-acetyl-D-galactosamine and sialic acid.	N-Acetylneuraminic Acid	191-202	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	148-153
15034044-6	2004	Our biochemical studies conclusively demonstrate that lupus IgG V(H)4.34 Abs target a developmentally regulated B220-specific glycoform of CD45, and more specifically, an N-linked N-acetyllactosamine determinant preferentially expressed on naive B cells that is sterically masked by sialic acid on B220-positive memory B cells.	N-Acetylneuraminic Acid	283-294	protein tyrosine phosphatase receptor type C	Homo sapiens	139-143
15009805-7	2004	The monoclonal antibodies revealed the existence of two Spalpha isoforms of 38 and 40 kDa, resulting from different sialic acid content.	N-Acetylneuraminic Acid	116-127	surfactant protein A1	Homo sapiens	56-63
15061693-4	2004	We are the first to measure GM3 synthase activity in human liver (194 +/- 60 pmol NeuAc/h per mg protein), which was about 10-fold lower than in phorbol myristate acetate-stimulated HL-60 cells (1353 +/- 573 pmol NeuAc/h per mg protein).	N-Acetylneuraminic Acid	82-87	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	28-40
15061693-4	2004	We are the first to measure GM3 synthase activity in human liver (194 +/- 60 pmol NeuAc/h per mg protein), which was about 10-fold lower than in phorbol myristate acetate-stimulated HL-60 cells (1353 +/- 573 pmol NeuAc/h per mg protein).	N-Acetylneuraminic Acid	213-218	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	28-40
14967177-4	2004	hCG molecules may vary in sialic acid content; this changes the acidity of the molecule.	N-Acetylneuraminic Acid	26-37	chorionic gonadotropin subunit beta 5	Homo sapiens	0-3
14984505-9	2004	If the terminal sialic acid was digested (via neuraminidase), this induced response was duplicated.	N-Acetylneuraminic Acid	16-27	neuraminidase 1	Homo sapiens	46-59
14972325-1	2004	Hereditary inclusion body myopathy (HIBM) is an adult onset neuromuscular disorder associated with mutations in the gene UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE), whose product is the rate limiting bi-functional enzyme catalyzing the first two steps of sialic acid biosynthesis.	N-Acetylneuraminic Acid	281-292	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	121-183
14972325-1	2004	Hereditary inclusion body myopathy (HIBM) is an adult onset neuromuscular disorder associated with mutations in the gene UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE), whose product is the rate limiting bi-functional enzyme catalyzing the first two steps of sialic acid biosynthesis.	N-Acetylneuraminic Acid	281-292	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	185-188
14972325-2	2004	Loss of GNE activity in HIBM is thought to impair sialic acid production and interfere with proper sialylation of glycoconjugates, but it remains unclear how such a defect would lead to muscle destruction and muscle weakness.	N-Acetylneuraminic Acid	50-61	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	8-11
15006695-1	2004	SLC17A5 encodes a lysosomal membrane protein, sialin, which transports sialic acid from lysosomes.	N-Acetylneuraminic Acid	71-82	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	0-7
15006695-1	2004	SLC17A5 encodes a lysosomal membrane protein, sialin, which transports sialic acid from lysosomes.	N-Acetylneuraminic Acid	71-82	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	46-52
14973250-5	2004	The 68 and 72 kDa molecular forms of inner ear CTL2 are distinguished by sialic acid modification of the carbohydrate.	N-Acetylneuraminic Acid	73-84	solute carrier family 44 member 2	Homo sapiens	47-51
14733909-4	2004	Removal of sialic acid by neuraminidase resulted in 10% reduction of Ca(2+) binding, whereas, sulfatase treatment reduced Ca(2+) binding by 30%.	N-Acetylneuraminic Acid	11-22	neuraminidase 1	Homo sapiens	26-39
14717696-5	2004	In this report we describe the identification of a lysosomal and a cytosolic OAE activity in human colonic mucosa that specifically hydrolyses 9-O-acetyl groups on sialic acid.	N-Acetylneuraminic Acid	164-175	sialic acid acetylesterase	Homo sapiens	77-80
14760639-1	2004	Carbohydrate-deficient transferrin (CDT) is the most specific marker for diagnosis of chronic excessive alcohol consumption and includes the serum transferrin (Tf) isoforms with two or less sialic acid residues (di-, mono-, and asialo-Tf).	N-Acetylneuraminic Acid	190-201	transferrin	Homo sapiens	23-34
14760639-1	2004	Carbohydrate-deficient transferrin (CDT) is the most specific marker for diagnosis of chronic excessive alcohol consumption and includes the serum transferrin (Tf) isoforms with two or less sialic acid residues (di-, mono-, and asialo-Tf).	N-Acetylneuraminic Acid	190-201	transferrin	Homo sapiens	147-158
14760639-1	2004	Carbohydrate-deficient transferrin (CDT) is the most specific marker for diagnosis of chronic excessive alcohol consumption and includes the serum transferrin (Tf) isoforms with two or less sialic acid residues (di-, mono-, and asialo-Tf).	N-Acetylneuraminic Acid	190-201	transferrin	Homo sapiens	160-162
14760639-4	2004	Enzymatic cleavage of sialic acid residues with neuraminidase and immunosubtraction were used to identify CDT isoforms.	N-Acetylneuraminic Acid	22-33	neuraminidase 1	Homo sapiens	48-61
14733963-2	2004	Here we report a Japanese patient with compound heterozygous missense mutations in the epimerase domain of GNE gene, 89 G to C and 578 A to T. Biochemical analysis demonstrated decreased reactivity of skeletal muscle glycoproteins with the lectins recognizing sialic acid residues.	N-Acetylneuraminic Acid	260-271	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	107-110
14698884-7	2004	The data reveal that sialoadhesin mainly recognizes the N-acetyl neuraminic acid and a small part of the galactose moiety of 1.	N-Acetylneuraminic Acid	56-80	sialic acid binding Ig like lectin 1	Homo sapiens	21-33
14672816-2	2004	Neuraminidase (sialidase) increases levels of GM1, a monosialoganglioside, in these neurons by enzymatic removal of sialic acid from abundant polysialylated gangliosides.	N-Acetylneuraminic Acid	116-127	coenzyme Q10A	Mus musculus	46-49
15133980-0	2004	TGF-beta and TNF-a affect cell surface proteoglycan and sialic acid expression on vascular endothelial cells.	N-Acetylneuraminic Acid	56-67	transforming growth factor beta 1	Homo sapiens	0-8
15133980-0	2004	TGF-beta and TNF-a affect cell surface proteoglycan and sialic acid expression on vascular endothelial cells.	N-Acetylneuraminic Acid	56-67	tumor necrosis factor	Homo sapiens	13-18
15133980-7	2004	Additionally, TNF-a decreased the number of sialic acid residues per cell and TGF-beta 1 slightly upregulated sialic acid expression as compared to the control.	N-Acetylneuraminic Acid	44-55	tumor necrosis factor	Homo sapiens	14-19
15133980-7	2004	Additionally, TNF-a decreased the number of sialic acid residues per cell and TGF-beta 1 slightly upregulated sialic acid expression as compared to the control.	N-Acetylneuraminic Acid	110-121	transforming growth factor beta 1	Homo sapiens	78-88
14514717-8	2004	In the case of complex-type N-glycans (partially) (alpha2-6)-sialylated (N-acetylneuraminic acid only), mono- and diantennary chains were found; part of the diantennary structures were (alpha1-6)-core-fucosylated or (alpha1-3)-fucosylated in the lower or upper antenna (Lewis x).	N-Acetylneuraminic Acid	73-96	immunoglobulin binding protein 1	Homo sapiens	51-59
15316281-11	2004	In addition, N-cadherin from WM9 (lymph node metastatic site) and A375 (solid tumor metastatic site) contained heavily alpha-fucosylated complex type chains with alpha2,3 linked sialic acid.	N-Acetylneuraminic Acid	178-189	cadherin 2	Homo sapiens	13-23
15001844-1	2004	In order to study the effect of glycosylation on its biological activities, and to develop IL-1alpha with less deleterious effects, recombinant human IL-1alpha was chemically coupled with N -acetylneuraminic acid (alpha1-6) galactose (Neu5Ac-Gal).	N-Acetylneuraminic Acid	188-212	interleukin 1 alpha	Homo sapiens	91-100
15001844-1	2004	In order to study the effect of glycosylation on its biological activities, and to develop IL-1alpha with less deleterious effects, recombinant human IL-1alpha was chemically coupled with N -acetylneuraminic acid (alpha1-6) galactose (Neu5Ac-Gal).	N-Acetylneuraminic Acid	188-212	interleukin 1 alpha	Homo sapiens	150-159
15001844-1	2004	In order to study the effect of glycosylation on its biological activities, and to develop IL-1alpha with less deleterious effects, recombinant human IL-1alpha was chemically coupled with N -acetylneuraminic acid (alpha1-6) galactose (Neu5Ac-Gal).	N-Acetylneuraminic Acid	188-212	adrenoceptor alpha 1D	Homo sapiens	214-222
15001844-7	2004	In addition, tissue level of Neu5Ac-Gal-IL-1alpha was relatively high compared to IL-1alpha.	N-Acetylneuraminic Acid	29-35	interleukin 1 alpha	Homo sapiens	40-49
15454696-3	2004	A recently characterized trafficking of ganglioside GD3 (GD3), a GSLs with two sialic-acid residues, to mitochondria has revealed a novel function of this lipid as a death effector.	N-Acetylneuraminic Acid	79-90	GRDX	Homo sapiens	52-55
15454696-3	2004	A recently characterized trafficking of ganglioside GD3 (GD3), a GSLs with two sialic-acid residues, to mitochondria has revealed a novel function of this lipid as a death effector.	N-Acetylneuraminic Acid	79-90	GRDX	Homo sapiens	57-60
14561743-1	2003	Lec3 Chinese hamster ovary (CHO) cell glycosylation mutants have a defect in sialic acid biosynthesis that is shown here to be reflected most sensitively in reduced polysialic acid (PSA) on neural cell adhesion molecules.	N-Acetylneuraminic Acid	77-88	adhesion G protein-coupled receptor L3	Homo sapiens	0-4
15209540-5	2004	Moreover, the marked age-related increase in structures Man (alpha1-2, alpha1-3, alpha1-6) Man, Fuc (alpha1-6) GlcNAc as well as Gal (beta1-3) GlcNAc was observed, whereas staining with terminal NeuAc and GlcNAc showed an inverse correlation.	N-Acetylneuraminic Acid	195-200	adrenoceptor alpha 1D	Homo sapiens	61-69
15209540-5	2004	Moreover, the marked age-related increase in structures Man (alpha1-2, alpha1-3, alpha1-6) Man, Fuc (alpha1-6) GlcNAc as well as Gal (beta1-3) GlcNAc was observed, whereas staining with terminal NeuAc and GlcNAc showed an inverse correlation.	N-Acetylneuraminic Acid	195-200	adrenoceptor alpha 1D	Homo sapiens	81-89
15209540-5	2004	Moreover, the marked age-related increase in structures Man (alpha1-2, alpha1-3, alpha1-6) Man, Fuc (alpha1-6) GlcNAc as well as Gal (beta1-3) GlcNAc was observed, whereas staining with terminal NeuAc and GlcNAc showed an inverse correlation.	N-Acetylneuraminic Acid	195-200	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	134-141
15481102-4	2004	The major fragments observed in the MALDI-TOF/TOF-MS/MS spectra result from cleavage of glycosidic bonds, preferentially at N-acetylhexosamine and sialic acid residues.	N-Acetylneuraminic Acid	147-158	FEZ family zinc finger 2	Homo sapiens	36-52
14667217-2	2003	A variety of structurally similar compounds have been reported that vary greatly in their ability to inhibit neuraminidase, a critical enzyme that cleaves sialic acid and promotes virion release.	N-Acetylneuraminic Acid	155-166	neuraminidase 1	Homo sapiens	109-122
14673092-5	2003	We found that the majority of the O-glycans that are linked to mZP3 are core type 2 sequences terminated with sialic acid, lacNAc (Galbeta1-4GlcNAc), lacdiNAc (Gal-NAcbeta1-4GlcNAc), Galalpha1-3Gal, and NeuAcalpha2-3[GalNAcbeta1-4]Galbeta1-4 (Sda antigen).	N-Acetylneuraminic Acid	110-121	zona pellucida glycoprotein 3	Mus musculus	63-67
14680834-0	2003	Inhibition of P-selectin-mediated cell adhesion by a sulfated derivative of sialic acid.	N-Acetylneuraminic Acid	76-87	selectin P	Homo sapiens	14-24
14690432-4	2003	Coexpression of SAS and UDP-GlcNAc 2-epimerase/ManNAc kinase, the bifunctional enzyme initiating sialic acid biosynthesis in mammals, resulted in Neu5Ac synthesis without use of any external media supplementation to demonstrate that Neu5Ac could be generated intracellularly in Sf9 cells using natural metabolic precursors.	N-Acetylneuraminic Acid	97-108	N-acetylneuraminate synthase	Homo sapiens	16-19
14690432-4	2003	Coexpression of SAS and UDP-GlcNAc 2-epimerase/ManNAc kinase, the bifunctional enzyme initiating sialic acid biosynthesis in mammals, resulted in Neu5Ac synthesis without use of any external media supplementation to demonstrate that Neu5Ac could be generated intracellularly in Sf9 cells using natural metabolic precursors.	N-Acetylneuraminic Acid	146-152	N-acetylneuraminate synthase	Homo sapiens	16-19
14690432-4	2003	Coexpression of SAS and UDP-GlcNAc 2-epimerase/ManNAc kinase, the bifunctional enzyme initiating sialic acid biosynthesis in mammals, resulted in Neu5Ac synthesis without use of any external media supplementation to demonstrate that Neu5Ac could be generated intracellularly in Sf9 cells using natural metabolic precursors.	N-Acetylneuraminic Acid	233-239	N-acetylneuraminate synthase	Homo sapiens	16-19
14690432-5	2003	N-Acetylglucosamine (GlcNAc) feeding in combination with this coexpression resulted in much higher levels of Neu5Ac compared to levels obtained with ManNAc feeding with SAS expression alone.	N-Acetylneuraminic Acid	109-115	N-acetylneuraminate synthase	Homo sapiens	169-172
14680834-3	2003	We examined the inhibitory effects of a synthetic sulfated derivative of sialic acid (NMSO3) on P-selectin-mediated cell adhesion and found the following: (1) P-selectin/IgG chimera bound to immobilized NMSO3.	N-Acetylneuraminic Acid	73-84	selectin P	Homo sapiens	96-106
14712354-5	2003	Treatment of the cells with sialidase reversed the inhibitory effect of podocalyxin, indicating that sialic acid residue is required for inhibition of cell adhesion.	N-Acetylneuraminic Acid	101-112	podocalyxin like	Homo sapiens	72-83
14680834-3	2003	We examined the inhibitory effects of a synthetic sulfated derivative of sialic acid (NMSO3) on P-selectin-mediated cell adhesion and found the following: (1) P-selectin/IgG chimera bound to immobilized NMSO3.	N-Acetylneuraminic Acid	73-84	selectin P	Homo sapiens	159-169
14654234-8	2003	Enzymatic removal of sialic acid residues from purified alpha(3)beta(1) integrin stimulates its adhesion to all examined ECM proteins.	N-Acetylneuraminic Acid	21-32	integrin subunit beta 1	Homo sapiens	64-80
14654234-8	2003	Enzymatic removal of sialic acid residues from purified alpha(3)beta(1) integrin stimulates its adhesion to all examined ECM proteins.	N-Acetylneuraminic Acid	21-32	multimerin 1	Homo sapiens	121-124
12944413-2	2003	The serotonin transporter (SERT) is an oligomeric glycoprotein with two sialic acid residues on each of two complex oligosaccharide molecules.	N-Acetylneuraminic Acid	72-83	solute carrier family 6 member 4	Homo sapiens	27-31
14645925-0	2003	Murine pneumotropic virus VP1 virus-like particles (VLPs) bind to several cell types independent of sialic acid residues and do not serologically cross react with murine polyomavirus VP1 VLPs.	N-Acetylneuraminic Acid	100-111	Major capsid protein VP1	Mus musculus polyomavirus 2	26-29
12952970-3	2003	Important variations were observed in the mucin-associated oligosaccharide content with an increasing gradient of sialic acid from the ileum to the colon associated with a reverse gradient of fucose.	N-Acetylneuraminic Acid	114-125	LOC100508689	Homo sapiens	42-47
12911452-5	2003	RESULTS: It was revealed that at 5-9 weeks of gestation, AFP variants that had been modified by the Fuc residue, which bound to the GlcNAc residue at the reducing end of the sugar chain, and bisecting GlcNAc residues gradually decreased as pregnancy advanced; however, the presence of N-acetylneuraminic acid (Neu5Ac) at the nonreducing ends changed little.	N-Acetylneuraminic Acid	285-308	alpha fetoprotein	Homo sapiens	57-60
12871854-4	2003	We now show that lung and salivary gp-340 inhibit the hemagglutination activity and infectivity of IAV and agglutinate the virions through a mechanism distinct from that of SP-D. As in the case of SP-A, the antiviral effects of gp-340 are mediated by noncalcium-dependent interactions between the virus and sialic acid-bearing carbohydrates on gp-340.	N-Acetylneuraminic Acid	307-318	deleted in malignant brain tumors 1	Homo sapiens	35-41
14559209-1	2003	We recently identified a novel human sialic acid binding immunoglobulin-like lectin, Siglec-8, using mRNA from human eosinophils.	N-Acetylneuraminic Acid	37-48	sialic acid binding Ig like lectin 8	Homo sapiens	85-93
14557669-2	2003	The enterotropism of TGEV is connected with the sialic acid binding activity of the viral surface protein S. Here we show that, among porcine intestinal brush border membrane proteins, TGEV recognizes a mucin-type glycoprotein designated MGP in a sialic acid-dependent fashion.	N-Acetylneuraminic Acid	247-258	matrix Gla protein	Homo sapiens	238-241
12927803-1	2003	The bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase is the key enzyme in sialic acid biosynthesis.	N-Acetylneuraminic Acid	82-93	renin binding protein	Homo sapiens	28-46
14575475-3	2003	These newly constructed bioactive sialic acid-based structures were differentially recognized by sialoadhesin, a mammalian macrophage sialic acid binding protein.	N-Acetylneuraminic Acid	34-45	sialic acid binding Ig like lectin 1	Homo sapiens	97-109
14575475-3	2003	These newly constructed bioactive sialic acid-based structures were differentially recognized by sialoadhesin, a mammalian macrophage sialic acid binding protein.	N-Acetylneuraminic Acid	134-145	sialic acid binding Ig like lectin 1	Homo sapiens	97-109
14575475-5	2003	Modulating the interaction between sialoadhesin and its sialic acid ligands has important implications in immunobiology.	N-Acetylneuraminic Acid	56-67	sialic acid binding Ig like lectin 1	Homo sapiens	35-47
14501137-1	2003	p75/AIRM1 (Siglec-7) is a sialic acid-binding Ig-like lectin recently identified as an inhibitory receptor on natural killer cells.	N-Acetylneuraminic Acid	26-37	sialic acid binding Ig like lectin 7	Homo sapiens	0-3
14501137-1	2003	p75/AIRM1 (Siglec-7) is a sialic acid-binding Ig-like lectin recently identified as an inhibitory receptor on natural killer cells.	N-Acetylneuraminic Acid	26-37	sialic acid binding Ig like lectin 7	Homo sapiens	4-9
14501137-1	2003	p75/AIRM1 (Siglec-7) is a sialic acid-binding Ig-like lectin recently identified as an inhibitory receptor on natural killer cells.	N-Acetylneuraminic Acid	26-37	sialic acid binding Ig like lectin 7	Homo sapiens	11-19
14604115-8	2003	Tf patterns are recognized and identified via detection times of Tf isoforms (intra-day and inter-day RSD values &lt; 1.0% and &lt; 1.7%, respectively), immunosubtraction of Tf and enzymatic sequential cleavage of sialic acid residues.	N-Acetylneuraminic Acid	214-225	transferrin	Homo sapiens	0-2
12911452-5	2003	RESULTS: It was revealed that at 5-9 weeks of gestation, AFP variants that had been modified by the Fuc residue, which bound to the GlcNAc residue at the reducing end of the sugar chain, and bisecting GlcNAc residues gradually decreased as pregnancy advanced; however, the presence of N-acetylneuraminic acid (Neu5Ac) at the nonreducing ends changed little.	N-Acetylneuraminic Acid	310-316	alpha fetoprotein	Homo sapiens	57-60
12959755-4	2003	Reovirus binding to both cell-surface sialic acid and junctional adhesion molecule 1 is required for NF-kappaB activation and apoptosis.	N-Acetylneuraminic Acid	38-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	101-110
12940824-1	2003	BACKGROUND: Glycophorin A (GPA) has a large number of sialic acid-containing oligosaccharide chains.	N-Acetylneuraminic Acid	54-65	glycophorin A	Mus musculus	12-25
12940824-1	2003	BACKGROUND: Glycophorin A (GPA) has a large number of sialic acid-containing oligosaccharide chains.	N-Acetylneuraminic Acid	54-65	glycophorin A	Mus musculus	27-30
12888916-7	2003	These data suggest that the enhancement of Fas-induced apoptosis by pre-treatment with neuraminidase was mediated by a caspase-9 dependent pathway closely associated with the loss of Deltapsim, not by activation of caspase-8, -6 or acidic and neutral sphingomyelinases, and that sialic acid linked to glycoconjugates of Fas may regulate Fas-induced apoptosis in human T cell lymphoma.	N-Acetylneuraminic Acid	279-290	neuraminidase 1	Homo sapiens	87-100
12927863-2	2003	Although apoB modification (cross-link and fragmentation) increases in atherosclerosis, the change in apoB-bound sialic acid in atherosclerosis is controversial.	N-Acetylneuraminic Acid	113-124	apolipoprotein B	Homo sapiens	102-106
12927863-5	2003	When human LDL was oxidized with Cu(2+) at 37 degrees C, apoB and apoB-attached sialic acid decreased simultaneously.	N-Acetylneuraminic Acid	80-91	apolipoprotein B	Homo sapiens	66-70
12927863-7	2003	In addition, human plasma was oxidized with 400 microM of Cu(2+) at 37 degrees C. Similar analysis indicates that the decrease in sialic acid attached to apoB also results from the fragmentation of apoB.	N-Acetylneuraminic Acid	130-141	apolipoprotein B	Homo sapiens	154-158
12927863-7	2003	In addition, human plasma was oxidized with 400 microM of Cu(2+) at 37 degrees C. Similar analysis indicates that the decrease in sialic acid attached to apoB also results from the fragmentation of apoB.	N-Acetylneuraminic Acid	130-141	apolipoprotein B	Homo sapiens	198-202
12940982-6	2003	In addition, macrophages expressing Sn, as well as transfectants expressing Sn or siglec-5, bound and phagocytosed sialylated bacteria in a siglec- and sialic acid-dependent manner.	N-Acetylneuraminic Acid	152-163	sialic acid binding Ig-like lectin F	Mus musculus	82-90
12897000-0	2003	Regulation of sialic acid catabolism by the DNA binding protein NanR in Escherichia coli.	N-Acetylneuraminic Acid	14-25	DNA-binding protein	Escherichia coli	44-63
12773526-6	2003	Most remarkable was the finding that myelin-associated glycoprotein (Siglec-4) binds with 500-10,000-fold higher affinity to a series of mono- and di-sialylated derivatives of the O-linked T-antigen (Galbeta(1-3)-GalNAc(alpha)OThr) as compared with alpha-methyl-NeuAc.	N-Acetylneuraminic Acid	262-267	myelin associated glycoprotein	Homo sapiens	37-67
12951019-2	2003	We found that neuraminidase treatment of RSV-infected cells to remove sialic acid (SA) increases fusion dramatically and that the same treatment of transiently transfected cells expressing the three viral glycoproteins, or even cells expressing the fusion (F) protein alone, results in easily detectable fusion.	N-Acetylneuraminic Acid	70-81	neuraminidase 1	Homo sapiens	14-27
12951019-2	2003	We found that neuraminidase treatment of RSV-infected cells to remove sialic acid (SA) increases fusion dramatically and that the same treatment of transiently transfected cells expressing the three viral glycoproteins, or even cells expressing the fusion (F) protein alone, results in easily detectable fusion.	N-Acetylneuraminic Acid	83-85	neuraminidase 1	Homo sapiens	14-27
14696756-13	2003	SA was strongly correlated with CRP (r = 0.59, p &lt; 0.0001), but not with patient age, any measure of blood pressure (BP), urea reduction ratio, plasma creatinine, lipid fractions or homocysteine.	N-Acetylneuraminic Acid	0-2	C-reactive protein	Homo sapiens	32-35
14628453-3	2003	METHODS: At first, N-glycans linked to asparagines in glycoprotein EPO were released by peptide N-glycosidase F. To map asialyated N-glycans, sialic acid in N-glycans were removed by incubating N-glycans with sialidase.	N-Acetylneuraminic Acid	142-153	erythropoietin	Homo sapiens	67-70
14628453-10	2003	In case of asialyated N-glycan mapping, the retention time of each oligosaccharide delayed greatly, and most importantly, the resulted sialic acid peak can be used as a quantitative standard to determine sialic acid content in N-glycans of EPO.	N-Acetylneuraminic Acid	135-146	erythropoietin	Homo sapiens	240-243
14628453-10	2003	In case of asialyated N-glycan mapping, the retention time of each oligosaccharide delayed greatly, and most importantly, the resulted sialic acid peak can be used as a quantitative standard to determine sialic acid content in N-glycans of EPO.	N-Acetylneuraminic Acid	204-215	erythropoietin	Homo sapiens	240-243
12818669-1	2003	A combined system of bismuth triflate [Bi(OTf)(3)] and boron trifluoride etherate (BF(3).OEt(2)) in dichloromethane is an efficient promoter for the glycosylation of N-acetylneuraminic acid derivatives.	N-Acetylneuraminic Acid	166-189	POU class 5 homeobox 1	Homo sapiens	39-48
12794687-1	2003	Salla disease, one of three disease phenotypes that manifest increased urinary excretion of unconjugated sialic acid, is an autosomal recessive condition caused by a mutation in SLC17A5.	N-Acetylneuraminic Acid	105-116	solute carrier family 17 member 5	Homo sapiens	178-185
12794687-2	2003	This gene encodes sialin, a lysosomal membrane transporter for sialic acid.	N-Acetylneuraminic Acid	63-74	solute carrier family 17 member 5	Homo sapiens	18-24
12794688-2	2003	These diseases, due to defective free sialic acid transport out of lysosomes, derive from mutations in the SLC17A5 gene coding for the protein sialin.	N-Acetylneuraminic Acid	38-49	solute carrier family 17 member 5	Homo sapiens	107-114
12794688-2	2003	These diseases, due to defective free sialic acid transport out of lysosomes, derive from mutations in the SLC17A5 gene coding for the protein sialin.	N-Acetylneuraminic Acid	38-49	solute carrier family 17 member 5	Homo sapiens	143-149
12850546-4	2003	In cells over-expressing either the wild type or mutant (M146L) PS1-FAD proteins, there was a decrease in the expression levels of protein-bound alpha2,3-linked sialic acid residues at the level of the cell membrane.	N-Acetylneuraminic Acid	161-172	presenilin 1	Homo sapiens	64-67
12880951-1	2003	Rodent cells, widely used for the industrial production of recombinant human glycoproteins, possess CMP-N-acetylneuraminic acid hydroxylase (CMP-Neu5Ac hydroxylase; EC 1.14.13.45) which is the key enzyme in the formation of the sialic acid, N-glycolylneuraminic acid (Neu5Gc).	N-Acetylneuraminic Acid	228-239	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	100-139
12880951-1	2003	Rodent cells, widely used for the industrial production of recombinant human glycoproteins, possess CMP-N-acetylneuraminic acid hydroxylase (CMP-Neu5Ac hydroxylase; EC 1.14.13.45) which is the key enzyme in the formation of the sialic acid, N-glycolylneuraminic acid (Neu5Gc).	N-Acetylneuraminic Acid	228-239	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	141-163
14562685-2	2003	The purified hCG-preparations from various blood group donors were shown to differ in their sialic acid content.	N-Acetylneuraminic Acid	92-103	hypertrichosis 2 (generalised, congenital)	Homo sapiens	13-16
12829649-3	2003	Statistically significant hazard ratios of developing diabetes for those in the fourth (versus first) quartile of inflammation markers, adjusted for age, sex, ethnicity, study center, parental history of diabetes, and hypertension, ranged from 1.9 to 2.8 for sialic acid, orosomucoid, interleukin-6, and C-reactive protein.	N-Acetylneuraminic Acid	259-270	interleukin 6	Homo sapiens	285-298
12829649-3	2003	Statistically significant hazard ratios of developing diabetes for those in the fourth (versus first) quartile of inflammation markers, adjusted for age, sex, ethnicity, study center, parental history of diabetes, and hypertension, ranged from 1.9 to 2.8 for sialic acid, orosomucoid, interleukin-6, and C-reactive protein.	N-Acetylneuraminic Acid	259-270	C-reactive protein	Homo sapiens	304-322
14696756-14	2003	Levels of the chronic inflammation marker sialic acid correlate strongly with CRP and are increased in patients with cardiovascular disease, but show no relationship to hemodialysis session.	N-Acetylneuraminic Acid	42-53	C-reactive protein	Homo sapiens	78-81
12748342-8	2003	In addition, asialo Galbeta1,3GalNAc was clearly present in cationic IgA from tonsillar extract and in aberrant IgA1 from serum following enzymatic transfer of sialic acid to IgA1.	N-Acetylneuraminic Acid	160-171	immunoglobulin heavy constant alpha 1	Homo sapiens	112-116
12861408-7	2003	Multiple regression analysis showed significant correlations between serum sialic acid and 2-h post-load glucose levels and insulin sensitivity.	N-Acetylneuraminic Acid	75-86	insulin	Homo sapiens	124-131
12783618-4	2003	The increased sialic acid content confers a three-fold longer half-life and allows the drug to be administered less frequently than epoetin alfa.	N-Acetylneuraminic Acid	14-25	erythropoietin	Homo sapiens	132-139
12626401-8	2003	Finally, serum-free medium supplemented with N-acetylneuraminic acid or N-acetylmannosamine supported glycoprotein sialylation by Sfbeta4GalT/ST6 cells but to a much lower degree than serum or fetuin.	N-Acetylneuraminic Acid	45-68	CD82 molecule	Homo sapiens	142-145
12626401-9	2003	These results provide the first evidence of a sialic acid salvaging pathway in insect cells, which begins to explain how Sfbeta4GalT/ST6 and other transgenic insect cell lines can sialylate recombinant glycoproteins in the absence of a more obvious source of CMP-sialic acid.	N-Acetylneuraminic Acid	46-57	CD82 molecule	Homo sapiens	133-136
12626401-9	2003	These results provide the first evidence of a sialic acid salvaging pathway in insect cells, which begins to explain how Sfbeta4GalT/ST6 and other transgenic insect cell lines can sialylate recombinant glycoproteins in the absence of a more obvious source of CMP-sialic acid.	N-Acetylneuraminic Acid	263-274	CD82 molecule	Homo sapiens	133-136
12737821-0	2003	Structure-guided design of sialic acid-based Siglec inhibitors and crystallographic analysis in complex with sialoadhesin.	N-Acetylneuraminic Acid	27-38	sialic acid binding Ig like lectin 1	Homo sapiens	109-121
12773563-1	2003	Mouse CD33/Siglec-3 (mCD33) is the apparent ortholog of human CD33/Siglec-3 (hCD33), a member of the Siglec (sialic acid-binding Ig superfamily lectin) family of sialic acid-recognizing cell-surface lectins.	N-Acetylneuraminic Acid	109-120	CD33 molecule	Homo sapiens	6-10
12773563-1	2003	Mouse CD33/Siglec-3 (mCD33) is the apparent ortholog of human CD33/Siglec-3 (hCD33), a member of the Siglec (sialic acid-binding Ig superfamily lectin) family of sialic acid-recognizing cell-surface lectins.	N-Acetylneuraminic Acid	109-120	CD33 molecule	Homo sapiens	11-19
12773563-1	2003	Mouse CD33/Siglec-3 (mCD33) is the apparent ortholog of human CD33/Siglec-3 (hCD33), a member of the Siglec (sialic acid-binding Ig superfamily lectin) family of sialic acid-recognizing cell-surface lectins.	N-Acetylneuraminic Acid	109-120	CD33 antigen	Mus musculus	21-26
12773563-1	2003	Mouse CD33/Siglec-3 (mCD33) is the apparent ortholog of human CD33/Siglec-3 (hCD33), a member of the Siglec (sialic acid-binding Ig superfamily lectin) family of sialic acid-recognizing cell-surface lectins.	N-Acetylneuraminic Acid	109-120	CD33 molecule	Homo sapiens	6-19
12773563-1	2003	Mouse CD33/Siglec-3 (mCD33) is the apparent ortholog of human CD33/Siglec-3 (hCD33), a member of the Siglec (sialic acid-binding Ig superfamily lectin) family of sialic acid-recognizing cell-surface lectins.	N-Acetylneuraminic Acid	109-120	CD33 molecule	Homo sapiens	77-82
12773563-1	2003	Mouse CD33/Siglec-3 (mCD33) is the apparent ortholog of human CD33/Siglec-3 (hCD33), a member of the Siglec (sialic acid-binding Ig superfamily lectin) family of sialic acid-recognizing cell-surface lectins.	N-Acetylneuraminic Acid	162-173	CD33 molecule	Homo sapiens	6-10
12773563-1	2003	Mouse CD33/Siglec-3 (mCD33) is the apparent ortholog of human CD33/Siglec-3 (hCD33), a member of the Siglec (sialic acid-binding Ig superfamily lectin) family of sialic acid-recognizing cell-surface lectins.	N-Acetylneuraminic Acid	162-173	CD33 molecule	Homo sapiens	11-19
12773563-1	2003	Mouse CD33/Siglec-3 (mCD33) is the apparent ortholog of human CD33/Siglec-3 (hCD33), a member of the Siglec (sialic acid-binding Ig superfamily lectin) family of sialic acid-recognizing cell-surface lectins.	N-Acetylneuraminic Acid	162-173	CD33 antigen	Mus musculus	21-26
12773563-1	2003	Mouse CD33/Siglec-3 (mCD33) is the apparent ortholog of human CD33/Siglec-3 (hCD33), a member of the Siglec (sialic acid-binding Ig superfamily lectin) family of sialic acid-recognizing cell-surface lectins.	N-Acetylneuraminic Acid	162-173	CD33 molecule	Homo sapiens	6-19
12773563-1	2003	Mouse CD33/Siglec-3 (mCD33) is the apparent ortholog of human CD33/Siglec-3 (hCD33), a member of the Siglec (sialic acid-binding Ig superfamily lectin) family of sialic acid-recognizing cell-surface lectins.	N-Acetylneuraminic Acid	162-173	CD33 molecule	Homo sapiens	77-82
12758164-9	2003	Two distinct glycosylation features were detected for GGT in metastatic tissue in contrast to normal liver GGT; an extreme sialic acid heterogeneity and a significant increase in beta1,6GlcNAc branching.	N-Acetylneuraminic Acid	123-134	gamma-glutamyltransferase light chain family member 3	Homo sapiens	54-57
12599255-6	2003	The quality of EPO produced at 33 degrees C in regard to isoform pattern, sialic acid content, and in vivo biological activity was comparable to or even better than that produced at 37 degrees C. Taken together, the results obtained demonstrate the potential of the application of low culture temperature to the commercial EPO production in rCHO cells.	N-Acetylneuraminic Acid	74-85	erythropoietin	Rattus norvegicus	15-18
12812265-7	2003	CRP demonstrated poor correlation with WBC (r = 0.458), while sialic acid strongly correlated with total absolute amount of alpha1 and alpha2 fractions in protein fractionation (r = 0.855) and moderately with ESR (r = 0.651).	N-Acetylneuraminic Acid	62-73	adrenoceptor alpha 1D	Homo sapiens	124-141
12945593-13	2003	The changes in serum proteins with terminal alpha 2-6 sialic acid correlated well with the alterations in the levels of sialic acid forms and sialyltransferase activity.	N-Acetylneuraminic Acid	54-65	immunoglobulin binding protein 1	Homo sapiens	44-53
12945593-13	2003	The changes in serum proteins with terminal alpha 2-6 sialic acid correlated well with the alterations in the levels of sialic acid forms and sialyltransferase activity.	N-Acetylneuraminic Acid	120-131	immunoglobulin binding protein 1	Homo sapiens	44-53
14506893-5	2003	The data show that an inflammatory phenotype, measured by serum sialic acid concentration, identifies individuals with insulin resistance, dyslipidaemia and hypertension.	N-Acetylneuraminic Acid	64-75	insulin	Homo sapiens	119-126
12737821-2	2003	The crystal structure of the N-terminal immunoglobulin-like domain of the Siglec sialoadhesin (SnD1) in complex with 2,3-sialyllactose has informed the design of sialic acid analogs (sialosides) that bind Siglecs with significantly enhanced affinities and specificities.	N-Acetylneuraminic Acid	162-173	sialic acid binding Ig like lectin 1	Homo sapiens	81-93
12737821-2	2003	The crystal structure of the N-terminal immunoglobulin-like domain of the Siglec sialoadhesin (SnD1) in complex with 2,3-sialyllactose has informed the design of sialic acid analogs (sialosides) that bind Siglecs with significantly enhanced affinities and specificities.	N-Acetylneuraminic Acid	162-173	staphylococcal nuclease and tudor domain containing 1	Homo sapiens	95-99
12556470-3	2003	Here we describe a paralogue of EBA-175 and show that this protein (EBA-181/JESEBL) binds in a sialic acid-dependent manner to erythrocytes.	N-Acetylneuraminic Acid	95-106	erythrocyte binding antigen-181	Plasmodium falciparum 3D7	68-75
12672957-9	2003	The EBA-175 ligand is functional in erythrocyte invasion by merozoites that utilize either sialic acid-dependent or -independent invasion pathways.	N-Acetylneuraminic Acid	91-102	erythrocyte binding antigen-175	Plasmodium falciparum 3D7	4-11
12691916-1	2003	OBJECTIVE: Experiments on human erythropoietin (EPO) demonstrated that there is a direct relationship between the sialic acid-containing carbohydrate content of EPO, its circulating half-life, and in vivo bioactivity.	N-Acetylneuraminic Acid	114-125	erythropoietin	Homo sapiens	32-46
12691916-10	2003	CONCLUSIONS: Increasing the sialic acid-containing carbohydrate content beyond the maximum found in EPO leads to a molecule with a longer circulating half-life and thereby an increased in vivo potency that can be administered less frequently.	N-Acetylneuraminic Acid	28-39	erythropoietin	Homo sapiens	100-103
12672957-1	2003	The Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175) is a ligand for merozoite invasion into human erythrocytes that binds to glycophorin A in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	160-171	erythrocyte binding antigen-175	Plasmodium falciparum 3D7	59-66
12672957-1	2003	The Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175) is a ligand for merozoite invasion into human erythrocytes that binds to glycophorin A in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	160-171	glycophorin A (MNS blood group)	Homo sapiens	141-154
12672957-4	2003	Lack of EBA-175 expression in W2mef parasites was associated with a switch to sialic acid-independent invasion.	N-Acetylneuraminic Acid	78-89	erythrocyte binding antigen-175	Plasmodium falciparum 3D7	8-15
12691916-1	2003	OBJECTIVE: Experiments on human erythropoietin (EPO) demonstrated that there is a direct relationship between the sialic acid-containing carbohydrate content of EPO, its circulating half-life, and in vivo bioactivity.	N-Acetylneuraminic Acid	114-125	erythropoietin	Homo sapiens	48-51
12691916-1	2003	OBJECTIVE: Experiments on human erythropoietin (EPO) demonstrated that there is a direct relationship between the sialic acid-containing carbohydrate content of EPO, its circulating half-life, and in vivo bioactivity.	N-Acetylneuraminic Acid	114-125	erythropoietin	Homo sapiens	161-164
12562385-10	2003	Third, removal of sialic acid residues with neuraminidase also sensitized CA to lysis.	N-Acetylneuraminic Acid	18-29	neuraminidase 1	Homo sapiens	44-57
12636412-1	2003	A practical sequence is described for converting d-glucosamine into peracetylated Gal(beta-1,4)GlcNTroc(beta1-S)Ph and Neu5Ac(alpha-2,3)Gal(beta-1,4)GlcNTroc(beta1-S)Ph building blocks using a synthetic strategy based on chemoenzymatic oligosaccharide synthesis.	N-Acetylneuraminic Acid	119-125	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	140-146
12499362-5	2003	Here we study the effects of GlcNAc 2-epimerase expression on sialic acid production in cells.	N-Acetylneuraminic Acid	62-73	renin binding protein	Homo sapiens	29-47
12499362-7	2003	Our results indicate that, unlike UDP-GlcNAc 2-epimerase, which promotes biosynthesis of sialic acid, GlcNAc 2-epimerase can serve a catabolic role, diverting metabolic flux away from the sialic acid pathway.	N-Acetylneuraminic Acid	89-100	renin binding protein	Homo sapiens	38-56
12499362-7	2003	Our results indicate that, unlike UDP-GlcNAc 2-epimerase, which promotes biosynthesis of sialic acid, GlcNAc 2-epimerase can serve a catabolic role, diverting metabolic flux away from the sialic acid pathway.	N-Acetylneuraminic Acid	188-199	renin binding protein	Homo sapiens	102-120
12444926-1	2003	N -Glycolylneuraminic acid (Neu5Gc), an abundant sialic acid in animal glycoconjugates, is formed by the enzyme CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase.	N-Acetylneuraminic Acid	49-60	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Sus scrofa	141-164
12615396-2	2003	However, Epo"s high glycosylation content (almost 40% of total mass) and the requirement for sialic acid for optimal in vivo activity still make mammalian cells the expression system of choice.	N-Acetylneuraminic Acid	93-104	erythropoietin	Homo sapiens	9-12
12668106-2	2003	The suitably protected lactotriose (Lc3) derivatives were successively glycosylated with sialic acid, sialyl-alpha-(2--&gt;3)-D-galactose and/or L-fucose donors in a regio- and stereo-selective manner, to give the protected type I hexa- and hepta-saccharides, respectively, which were then converted to the target gangliosides by the introduction of ceramide and subsequent complete deprotection.	N-Acetylneuraminic Acid	89-100	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	36-39
12499362-0	2003	GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism.	N-Acetylneuraminic Acid	49-60	renin binding protein	Homo sapiens	0-18
12737237-10	2003	The structure of the major sialylglycan in Silky egg yolk was determined to be a disialyl-biantennary chain in which the NeuAc residues were alpha2-6 linked to glucose.	N-Acetylneuraminic Acid	121-126	immunoglobulin binding protein 1	Homo sapiens	141-149
12459555-0	2003	Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction.	N-Acetylneuraminic Acid	0-11	CD8b molecule	Homo sapiens	23-30
12598072-10	2003	The addition of sialic acid, which inhibits RBC-RBC aggregation, decreased the amount of SEC, even in the presence of Fg.	N-Acetylneuraminic Acid	16-27	fibrinogen beta chain	Homo sapiens	118-120
12552011-0	2003	Amino acid substitutions in VP2 residues contacting sialic acid in low-neurovirulence BeAn virus dramatically reduce viral binding and spread of infection.	N-Acetylneuraminic Acid	52-63	brain expressed, associated with Nedd4, 1	Mus musculus	86-90
12601737-4	2003	The different content in sialic acid groups between recombinant and endogenous EPO provide a basis for their distinction by CZE.	N-Acetylneuraminic Acid	25-36	erythropoietin	Homo sapiens	79-82
12560567-5	2003	Removal of sialic acid from HIV by NA also significantly enhanced virus binding and neutralization by MBL.	N-Acetylneuraminic Acid	11-22	mannose binding lectin 2	Homo sapiens	102-105
12552011-7	2003	Our data suggest that residues Q2161 and G2174 are directly involved in BeAn virus attachment to sialic acid and that substitutions of these two residues result in the loss of or reduced viral binding and hemagglutination and in the inability to spread among BHK-21 cells.	N-Acetylneuraminic Acid	97-108	brain expressed, associated with Nedd4, 1	Mus musculus	72-76
12765789-7	2003	Both ST8Sia II and IV can transfer multiple alpha 2,8-linked sialic acid residues to an acceptor N-glycan containing a NeuNAc alpha 2--&gt;3 (or 6) Gal beta 1--&gt;4GlcNAc beta 1--&gt;R structure without participation of other enzymes.	N-Acetylneuraminic Acid	61-72	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	5-14
12527415-0	2003	A single site in human beta-hexosaminidase A binds both 6-sulfate-groups on hexosamines and the sialic acid moiety of GM2 ganglioside.	N-Acetylneuraminic Acid	96-107	hexosaminidase subunit alpha	Homo sapiens	23-44
12527415-5	2003	To determine if these same residues affect the binding of the sialic acid moiety of GM2 ganglioside, an alphaArg(424)Gln form of Hex A was expressed and its kinetics analyzed using the GM2 activator protein:[3H]-GM2 ganglioside complex as a substrate.	N-Acetylneuraminic Acid	62-73	hexosaminidase subunit alpha	Homo sapiens	129-134
12438315-8	2003	In the Siglec-7 structure, the ligand-binding pocket is occupied by a loop of a symmetry-related molecule, mimicking the interactions with sialic acid.	N-Acetylneuraminic Acid	139-150	sialic acid binding Ig like lectin 7	Homo sapiens	7-15
12477836-0	2003	Mutations in human parainfluenza virus type 3 hemagglutinin-neuraminidase causing increased receptor binding activity and resistance to the transition state sialic acid analog 4-GU-DANA (Zanamivir).	N-Acetylneuraminic Acid	157-168	hemagglutinin-neuraminidase	Human respirovirus 3	46-73
12432463-5	2003	Lectin activity of our isolate was strongly inhibited by preincubation with D-mannose, but not with the six other monosaccharides: D-galactose, D-glucose, L-fucose, N-acetyl- D-glucosamine, N-acetyl- D-galactosamine, and N-acetylneuraminic acid.	N-Acetylneuraminic Acid	221-244	hemocytin	Bombyx mori	0-6
12523830-4	2003	The sialopeptide libraries were screened against the recombinant binding domain (SnD1) of a sialic acid binding Ig-like protein, sialoadhesin (Siglec-1).	N-Acetylneuraminic Acid	92-103	staphylococcal nuclease and tudor domain containing 1	Homo sapiens	81-85
12523830-4	2003	The sialopeptide libraries were screened against the recombinant binding domain (SnD1) of a sialic acid binding Ig-like protein, sialoadhesin (Siglec-1).	N-Acetylneuraminic Acid	92-103	sialic acid binding Ig like lectin 1	Homo sapiens	129-141
12523830-4	2003	The sialopeptide libraries were screened against the recombinant binding domain (SnD1) of a sialic acid binding Ig-like protein, sialoadhesin (Siglec-1).	N-Acetylneuraminic Acid	92-103	sialic acid binding Ig like lectin 1	Homo sapiens	143-151
12450772-4	2003	The dominantly inherited French type sialuria seems to result from defective allosteric feedback inhibitory regulation of GNE/MNK by cytidine monophosphate-N-acetylneuraminic acid (CMP-NANA), resulting in overproduction of cytosolic N-acetylneuraminic acid, and massive urinary excretion of free sialic acid.	N-Acetylneuraminic Acid	156-179	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	122-125
12450772-4	2003	The dominantly inherited French type sialuria seems to result from defective allosteric feedback inhibitory regulation of GNE/MNK by cytidine monophosphate-N-acetylneuraminic acid (CMP-NANA), resulting in overproduction of cytosolic N-acetylneuraminic acid, and massive urinary excretion of free sialic acid.	N-Acetylneuraminic Acid	156-179	ATPase copper transporting alpha	Homo sapiens	126-129
12450772-4	2003	The dominantly inherited French type sialuria seems to result from defective allosteric feedback inhibitory regulation of GNE/MNK by cytidine monophosphate-N-acetylneuraminic acid (CMP-NANA), resulting in overproduction of cytosolic N-acetylneuraminic acid, and massive urinary excretion of free sialic acid.	N-Acetylneuraminic Acid	296-307	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	122-125
12450772-4	2003	The dominantly inherited French type sialuria seems to result from defective allosteric feedback inhibitory regulation of GNE/MNK by cytidine monophosphate-N-acetylneuraminic acid (CMP-NANA), resulting in overproduction of cytosolic N-acetylneuraminic acid, and massive urinary excretion of free sialic acid.	N-Acetylneuraminic Acid	296-307	ATPase copper transporting alpha	Homo sapiens	126-129
12531524-3	2002	Here we show that the differential subsynaptic distribution of these antigens is due to a preference of CT1 for structures containing N-acetyl neuraminic acid (NeuAc) and a preference of CT2 for structures containing N-glycolyl neuraminic acid (NeuGc).	N-Acetylneuraminic Acid	134-158	cardiotrophin 1	Mus musculus	104-107
12471127-1	2002	Factor H (FH) is a potent suppressor of the alternative pathway of C in plasma and when bound to sialic acid- or glycosaminoglycan-rich surfaces.	N-Acetylneuraminic Acid	97-108	complement factor H	Homo sapiens	0-8
12379325-2	2002	Fluorescein isothiocyanate (FITC)-conjugated peptides corresponding to a portion of the MUC1 tandem repeat were enzymatically glycosylated with N-acetylgalactosamine, galactose, and then sialic acid.	N-Acetylneuraminic Acid	187-198	mucin 1, cell surface associated	Homo sapiens	88-92
12379642-4	2002	The kinetic analysis of ST3Gal I inhibition demonstrated that this hexapeptide could act as a competitive inhibitor (K(i) = 1.1 microm) on CMP-NeuAc binding to the enzyme.	N-Acetylneuraminic Acid	143-148	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	24-32
12504583-6	2002	These results indicate that low-neurovirulence BeAn virus uses a sialic acid moiety expressed on an N-linked carbohydrate of a glycoprotein that serves as the protein entry receptor.	N-Acetylneuraminic Acid	65-76	brain expressed, associated with Nedd4, 1	Mus musculus	47-51
12471127-1	2002	Factor H (FH) is a potent suppressor of the alternative pathway of C in plasma and when bound to sialic acid- or glycosaminoglycan-rich surfaces.	N-Acetylneuraminic Acid	97-108	complement factor H	Homo sapiens	10-12
12463751-5	2002	Using three variants of EPO containing different levels of sialylation, we determined that sialic acid decreased the association rate constant (k(on)) about 3-fold.	N-Acetylneuraminic Acid	91-102	erythropoietin	Homo sapiens	24-27
12438625-7	2002	We show that the neoglycoprotein containing the terminal alpha2-6-linked sialic acid had the highest affinity for VLP, inhibited the hemagglutination activity of VLP and JCV, and inhibited the attachment of VLP to cells.	N-Acetylneuraminic Acid	73-84	VHL like	Homo sapiens	114-117
12324456-11	2002	Dot-blot assay showed that annexin IV interacts with GP-2 in the presence of calcium and that it recognizes the terminal sialic acid residues linked through alpha2-3 linkages to the carbohydrate of GP-2.	N-Acetylneuraminic Acid	121-132	annexin A4	Bos taurus	27-37
12171601-10	2002	Finally, expression of sialic-acid-deficient wt-hPAR(2) in the CHO Lec2 glycosylation-deficient mutant cell line, showed a 40 kDa loss in molecular mass, in addition to a marked and selective increase in sensitivity towards tryptase.	N-Acetylneuraminic Acid	23-34	F2R like trypsin receptor 1	Homo sapiens	48-55
12232676-11	2002	The number of sialic acid residues was estimated to be 29 and 45, for each B1 and B2 homodimer, respectively.	N-Acetylneuraminic Acid	14-25	membrane spanning 4-domains A1	Homo sapiens	75-84
12232676-14	2002	In summary, our data indicate that B1 and B2 have more (or more reactive) sialic acid residues compared with B/I, which mainly explains the apparent differences in molecular weight.	N-Acetylneuraminic Acid	74-85	membrane spanning 4-domains A1	Homo sapiens	35-44
12474053-10	2002	CONCLUSIONS: These results indicate that the antitumor activity of GM3/VSSP is associated with GM3 expression on tumor cell surface and demonstrate a major role of sialic acid in the humoral response of vaccinated mice.	N-Acetylneuraminic Acid	164-175	granulocyte macrophage antigen 3	Mus musculus	67-70
12441907-2	2002	To elucidate the mechanism of the relation of serum sialic acid to fibrinogen, the relationship between serum sialic acid and markers of blood coagulation activity was investigated in type 2 diabetic patients.	N-Acetylneuraminic Acid	52-63	fibrinogen beta chain	Homo sapiens	67-77
12441907-3	2002	The concentration of serum sialic acid showed significant positive correlations with blood platelet count and with plasma concentrations of fibrinogen, D-dimer, thrombin-antithrombin III complex and plasmin-alpha2 plasmin inhibitor complex.	N-Acetylneuraminic Acid	27-38	fibrinogen beta chain	Homo sapiens	140-150
12441907-5	2002	The correlation coefficient of blood fibrinogen with serum sialic acid was still significant after adjustment for D-dimer, thrombin-antithrombin III complex or plasmin-alpha2 plasmin inhibitor complex.	N-Acetylneuraminic Acid	59-70	fibrinogen beta chain	Homo sapiens	37-47
12441907-7	2002	These results suggest that the serum sialic acid level reflects blood coagulation activity in type 2 diabetic patients and is related to blood fibrinogen level independently of blood coagulation activity.	N-Acetylneuraminic Acid	37-48	fibrinogen beta chain	Homo sapiens	143-153
12559410-0	2002	Met-enkephalin modulates lipid peroxidation and total sialic acid level in CBA mice in age- and sex-dependent manners.	N-Acetylneuraminic Acid	54-65	pro-opiomelanocortin-alpha	Mus musculus	0-14
12438625-7	2002	We show that the neoglycoprotein containing the terminal alpha2-6-linked sialic acid had the highest affinity for VLP, inhibited the hemagglutination activity of VLP and JCV, and inhibited the attachment of VLP to cells.	N-Acetylneuraminic Acid	73-84	VHL like	Homo sapiens	162-165
12438625-7	2002	We show that the neoglycoprotein containing the terminal alpha2-6-linked sialic acid had the highest affinity for VLP, inhibited the hemagglutination activity of VLP and JCV, and inhibited the attachment of VLP to cells.	N-Acetylneuraminic Acid	73-84	VHL like	Homo sapiens	162-165
12487819-0	2002	High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1.	N-Acetylneuraminic Acid	25-36	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	40-45
12487819-0	2002	High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1.	N-Acetylneuraminic Acid	25-36	mannose binding lectin 2	Homo sapiens	66-88
12487819-0	2002	High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1.	N-Acetylneuraminic Acid	25-36	mannose binding lectin 2	Homo sapiens	90-93
12397023-3	2002	Both CF-KM4 and MM-39 cells failed to express the Coxsackie-Ad receptor (CAR), and experimental data suggested that alpha[2--&gt;6]-linked sialic acid residues of sialoglycoproteins (SAGP) in CF-KM4 cells, and heparan sulfate glycosaminoglycans (HS-GAG) in MM-39, were used as receptors by Ad5 virions.	N-Acetylneuraminic Acid	139-150	Alzheimer disease, familial, type 5	Homo sapiens	290-293
12359136-0	2002	Unraveling the molecular pathogenesis of free sialic acid storage disorders: altered targeting of mutant sialin.	N-Acetylneuraminic Acid	46-57	solute carrier family 17 member 5	Homo sapiens	105-111
12495288-8	2002	In view of the incompleteness of the IgA1 sugar chain, the decrease in the sialic acid content of the mucin-type sugar chain on IgA1 from an IgA nephropathy patient became obvious in this experiment.	N-Acetylneuraminic Acid	75-86	immunoglobulin heavy constant alpha 1	Homo sapiens	128-132
12393190-1	2002	GM3 synthase, which transfers CMP-NeuAc with an alpha2,3-linkage to a galactose residue of lactosylceramide, plays a key role in the biosynthesis of all complex gangliosides.	N-Acetylneuraminic Acid	34-39	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	0-12
12450065-6	2002	Preincubation of aorta with neuraminidase to remove cell-surface sialic acid unmasked the ability of tryptase to induce relaxation of the aorta, but had no effect on relaxation induced by trypsin, SLIGRL-NH2, or acetylcholine (Ach).	N-Acetylneuraminic Acid	65-76	tryptase alpha/beta 1	Rattus norvegicus	101-109
12450065-9	2002	We conclude that tryptase-induced relaxation of rat aorta, most likely via PAR2, is tightly regulated by heparin and cell-surface sialic acid.	N-Acetylneuraminic Acid	130-141	tryptase alpha/beta 1	Rattus norvegicus	17-25
12435169-1	2002	Studies on human erythropoietin (EPO) demonstrated that there is a direct relationship between the sialic acid-containing carbohydrate content of the molecule and its serum half-life and in vivo biological activity, but an inverse relationship with its receptor-binding affinity.	N-Acetylneuraminic Acid	99-110	erythropoietin	Homo sapiens	17-31
12435169-1	2002	Studies on human erythropoietin (EPO) demonstrated that there is a direct relationship between the sialic acid-containing carbohydrate content of the molecule and its serum half-life and in vivo biological activity, but an inverse relationship with its receptor-binding affinity.	N-Acetylneuraminic Acid	99-110	erythropoietin	Homo sapiens	33-36
12091385-6	2002	Consistent with the observation that cells with hyposialylated integrins are more adhesive to fibronectin, we demonstrate that the enzymatic removal of sialic acid residues from purified alpha(5)beta(1) integrins stimulates fibronectin binding by these integrins.	N-Acetylneuraminic Acid	152-163	fibronectin 1	Homo sapiens	94-105
12091385-6	2002	Consistent with the observation that cells with hyposialylated integrins are more adhesive to fibronectin, we demonstrate that the enzymatic removal of sialic acid residues from purified alpha(5)beta(1) integrins stimulates fibronectin binding by these integrins.	N-Acetylneuraminic Acid	152-163	fibronectin 1	Homo sapiens	224-235
12192086-1	2002	Humans are genetically deficient in the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an Alu-mediated inactivating mutation of the gene encoding the enzyme CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase (CMAH).	N-Acetylneuraminic Acid	57-68	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	214-237
12192086-1	2002	Humans are genetically deficient in the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an Alu-mediated inactivating mutation of the gene encoding the enzyme CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase (CMAH).	N-Acetylneuraminic Acid	57-68	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	239-243
12192086-1	2002	Humans are genetically deficient in the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an Alu-mediated inactivating mutation of the gene encoding the enzyme CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase (CMAH).	N-Acetylneuraminic Acid	189-212	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	214-237
12192086-1	2002	Humans are genetically deficient in the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an Alu-mediated inactivating mutation of the gene encoding the enzyme CMP-N-acetylneuraminic acid (CMP-Neu5Ac) hydroxylase (CMAH).	N-Acetylneuraminic Acid	189-212	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	239-243
12015815-7	2002	A majority of the oligosaccharides could be described by the formula dHex(0--&gt;2)NeuAc(1--&gt;)(x)Hex(x)HexNAc(x)(-ol), x=1-6, where Hex stands for hexose, dHex for deoxyhexose, HexNAc for N-acetylhexosamine and NeuAc for N-acetylneuraminate.	N-Acetylneuraminic Acid	83-88	hematopoietically expressed homeobox	Homo sapiens	70-73
12015815-7	2002	A majority of the oligosaccharides could be described by the formula dHex(0--&gt;2)NeuAc(1--&gt;)(x)Hex(x)HexNAc(x)(-ol), x=1-6, where Hex stands for hexose, dHex for deoxyhexose, HexNAc for N-acetylhexosamine and NeuAc for N-acetylneuraminate.	N-Acetylneuraminic Acid	83-88	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	122-127
12015815-7	2002	A majority of the oligosaccharides could be described by the formula dHex(0--&gt;2)NeuAc(1--&gt;)(x)Hex(x)HexNAc(x)(-ol), x=1-6, where Hex stands for hexose, dHex for deoxyhexose, HexNAc for N-acetylhexosamine and NeuAc for N-acetylneuraminate.	N-Acetylneuraminic Acid	83-88	hematopoietically expressed homeobox	Homo sapiens	100-103
12530538-3	2002	The sialidase removed terminal sialic acids from gangliosides GM3, GM4, GD3, GD2, GD1 a, GD1 b, GT1 b and GQ1 b, but was inactive toward gangliosides with sialic acid in a branching position (as in GM1 and GM2).	N-Acetylneuraminic Acid	31-42	GRDX	Homo sapiens	72-75
12530538-3	2002	The sialidase removed terminal sialic acids from gangliosides GM3, GM4, GD3, GD2, GD1 a, GD1 b, GT1 b and GQ1 b, but was inactive toward gangliosides with sialic acid in a branching position (as in GM1 and GM2).	N-Acetylneuraminic Acid	31-42	beta-1,4-galactosyltransferase 1	Homo sapiens	96-99
12530538-4	2002	Lyso-GM3 and -GD1a were good substrates, too, whereas O-acetylation of the sialic acid as in 9-O-acetyl-GD3 caused strongly reduced cleavage.	N-Acetylneuraminic Acid	75-86	GRDX	Homo sapiens	104-107
12358929-0	2002	Human Siglec-5: tissue distribution, novel isoforms and domain specificities for sialic acid-dependent ligand interactions.	N-Acetylneuraminic Acid	81-92	sialic acid binding Ig like lectin 5	Homo sapiens	6-14
12358929-1	2002	Human Siglec-5 is a sialic acid binding immunoglobulin (Ig)-like lectin (Siglec), comprising one N-terminal IgV-SET domain followed by three IgC2-SET domains, and a cytoplasmic domain with ITIM and SAP motifs which regulate cell signalling.	N-Acetylneuraminic Acid	20-31	sialic acid binding Ig like lectin 5	Homo sapiens	6-14
12358929-6	2002	A soluble Fc chimaeric protein containing the hSiglec-5-4L extracellular domain binds in a sialic acid-dependent manner to glycophorin A on human erythrocytes and to alpha2-3- and alpha2-6-sialyllactose moieties.	N-Acetylneuraminic Acid	91-102	sialic acid binding Ig like lectin 5	Homo sapiens	46-55
12358929-6	2002	A soluble Fc chimaeric protein containing the hSiglec-5-4L extracellular domain binds in a sialic acid-dependent manner to glycophorin A on human erythrocytes and to alpha2-3- and alpha2-6-sialyllactose moieties.	N-Acetylneuraminic Acid	91-102	glycophorin A (MNS blood group)	Homo sapiens	123-136
12358929-6	2002	A soluble Fc chimaeric protein containing the hSiglec-5-4L extracellular domain binds in a sialic acid-dependent manner to glycophorin A on human erythrocytes and to alpha2-3- and alpha2-6-sialyllactose moieties.	N-Acetylneuraminic Acid	91-102	immunoglobulin binding protein 1	Homo sapiens	180-188
12358929-8	2002	This indicates that each hSiglec-5 isoform will interact with sialic acid ligands and provides the first step towards defining structure-function relationships of hSiglec-5 isoforms.	N-Acetylneuraminic Acid	62-73	sialic acid binding Ig like lectin 5	Homo sapiens	25-34
12358929-8	2002	This indicates that each hSiglec-5 isoform will interact with sialic acid ligands and provides the first step towards defining structure-function relationships of hSiglec-5 isoforms.	N-Acetylneuraminic Acid	62-73	sialic acid binding Ig like lectin 5	Homo sapiens	163-172
12068010-9	2002	However, overall expression of alpha2-3-linked sialic acid was selectively reduced only in a few instances, indicating that other ST3Gal enzymes can generate this linkage in most tissues.	N-Acetylneuraminic Acid	47-58	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	31-39
12181064-4	2002	The response was glycophorin A specific as Concanavalin A, which binds to band 3, did not cause haemolysis and peanut agglutinin only did so after removal of erythrocyte sialic acid.	N-Acetylneuraminic Acid	170-181	glycophorin A (MNS blood group)	Homo sapiens	17-30
12359136-2	2002	The gene product, sialin, is a lysosomal membrane protein which transports free sialic acid across the membrane.	N-Acetylneuraminic Acid	80-91	solute carrier family 17 member 5	Homo sapiens	18-24
12145189-5	2002	Employing solid phase binding assays, rViscumin was shown to preferentially bind to terminally alpha2-6-sialylated neolacto-series gangliosides IV(6)Neu5Ac-nLc4Cer, VI(6)Neu5Ac-nLc6Cer, and VIII(6)Neu5Ac-nLc8Cer isolated from human granulocytes.	N-Acetylneuraminic Acid	149-155	immunoglobulin binding protein 1	Homo sapiens	95-103
12223090-8	2002	Transferred sialic acid is found to be alpha2-6, alpha2-3, and alpha2-8 connected.	N-Acetylneuraminic Acid	12-23	immunoglobulin binding protein 1	Homo sapiens	39-47
12223090-8	2002	Transferred sialic acid is found to be alpha2-6, alpha2-3, and alpha2-8 connected.	N-Acetylneuraminic Acid	12-23	immunoglobulin binding protein 1	Homo sapiens	63-71
12057664-0	2002	Effect of protonation of the N-acetyl neuraminic acid residue of sialyl Lewis(X): a molecular orbital study with insights into its binding properties toward the carbohydrate recognition domain of E-selectin.	N-Acetylneuraminic Acid	29-53	selectin E	Homo sapiens	196-206
12160746-5	2002	Binding of MAG to NgR-expressing cells is GPI dependent and sialic acid independent.	N-Acetylneuraminic Acid	60-71	reticulon 4 receptor	Homo sapiens	18-21
12000758-7	2002	By contrast, MCF-7, MDA-MB231, and ZR75-1 cells glycosylate the MUC1 repeat peptide preferentially with core 2-based glycans terminating mostly with alpha 3-linked sialic acid (MDA-MB231, ZR75-1) or alpha 2/3-linked fucose (MCF-7).	N-Acetylneuraminic Acid	164-175	mucin 1, cell surface associated	Homo sapiens	64-68
12130703-7	2002	Moreover, removal of sialic acid from peritoneal mast cells, using neuraminidase (2 U/ml), inhibited Cit- (10 microM, 52%) and tc-LIGRLO-NH(2) (0.5 microM, 29%)-mediated beta-hexosaminidase release.	N-Acetylneuraminic Acid	21-32	O-GlcNAcase	Homo sapiens	170-189
12166519-4	2002	Treatment of bovine and non-bovine erythrocytes with neuraminidase decreased their susceptibility to invasion by up to 97% implicating sialic acid as an important erythrocyte ligand for babesia, but the addition of either bovine or human N-acetylneuraminyl-lactose to B. divergens cultures in bovine erythrocytes had no inhibitory effect.	N-Acetylneuraminic Acid	135-146	neuraminidase 1	Bos taurus	53-66
12003573-5	2002	The utility of this strategy is demonstrated by its application to the syntheses of protected derivatives of D- and L-3-amino-3-deoxyxylose, L-3-amino-3-deoxyarabinose, and a late-stage intermediate in a potential route to N-acetylneuraminic acid.	N-Acetylneuraminic Acid	223-246	immunoglobulin kappa variable 2-14 (pseudogene)	Homo sapiens	116-119
12135555-1	2002	The CMP-sialic acid synthetase (CMP-Neu5Ac, synthetase) is responsible for the synthesis of CMP-Neu5Ac, which is the donor used by sialyltransferases to attach sialic acid to acceptor hydroxyl groups in various polysaccharides, glycolipids, and glycoproteins.	N-Acetylneuraminic Acid	8-19	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	32-54
12044171-6	2002	Abeta recognized ganglioside clusters, the density of which increased with the number of sialic acid residues.	N-Acetylneuraminic Acid	89-100	amyloid beta precursor protein	Homo sapiens	0-5
12088651-1	2002	Most oropharyngeal pathogens express sialic acid units on their surfaces, mimicking the sialyl-rich mucin layer coating epithelial cells and the glycoconjugates present on virtually all host cell surfaces and serum proteins.	N-Acetylneuraminic Acid	37-48	LOC100508689	Homo sapiens	100-105
12003573-5	2002	The utility of this strategy is demonstrated by its application to the syntheses of protected derivatives of D- and L-3-amino-3-deoxyxylose, L-3-amino-3-deoxyarabinose, and a late-stage intermediate in a potential route to N-acetylneuraminic acid.	N-Acetylneuraminic Acid	223-246	immunoglobulin kappa variable 2-14 (pseudogene)	Homo sapiens	141-144
12182913-8	2002	Most of the platelet total sialic acid was susceptible to cleavage by neuraminidase, demonstrating sialic acid to be preferably localized at the outer platelet surface.	N-Acetylneuraminic Acid	27-38	neuraminidase 1	Homo sapiens	70-83
11994425-0	2002	Sialic acid binding domains of CD22 are required for negative regulation of B cell receptor signaling.	N-Acetylneuraminic Acid	0-11	CD22 antigen	Mus musculus	31-35
11994425-3	2002	We asked whether the sialic acid binding domains are necessary for CD22 to function as a negative regulator.	N-Acetylneuraminic Acid	21-32	CD22 antigen	Mus musculus	67-71
11964282-8	2002	Inhibition of CD33 phosphorylation with pharmacologic agents resulted in an increase of sialic acid-dependent rosette formation.	N-Acetylneuraminic Acid	88-99	LOW QUALITY PROTEIN: myeloid cell surface antigen CD33	Cricetulus griseus	14-18
12182913-8	2002	Most of the platelet total sialic acid was susceptible to cleavage by neuraminidase, demonstrating sialic acid to be preferably localized at the outer platelet surface.	N-Acetylneuraminic Acid	99-110	neuraminidase 1	Homo sapiens	70-83
11970770-1	2002	The CD33 antigen is a 67-kd glycosylated transmembrane protein of the sialic acid-binding immunoglobulinlike lectin (siglec) family with immunoreceptor tyrosine-based inhibitory motifs.	N-Acetylneuraminic Acid	70-81	CD33 molecule	Homo sapiens	4-8
12059075-4	2002	Significant negative correlation between soluble intercellular adhesion molecule-1 level and erythrocyte membrane sialic acid concentration (r=-0.49, p&lt;0.001) and positive correlations between soluble intercellular adhesion molecule-1 level and Ritche Articular Index score and C-reactive protein (r=0.32, p&lt;0.05; r=0.44, p&lt;0.01, respectively) were observed.	N-Acetylneuraminic Acid	114-125	intercellular adhesion molecule 1	Homo sapiens	49-82
11963378-7	2002	NESP possesses five N-linked oligosaccharide chains and two times more sialic acid residues than rHuEPO.	N-Acetylneuraminic Acid	71-82	GNAS complex locus	Homo sapiens	0-4
11828373-1	2002	CD22 is a B cell-specific member of the immunoglobulin superfamily and binds to sialic acid.	N-Acetylneuraminic Acid	80-91	CD22 antigen	Mus musculus	0-4
11867604-11	2002	LC-ESMS analysis of tryptic peptides indicated that PEDF A and B exhibit differences in glycopeptides containing N-acetylneuraminic acid (NeuAc) and N-acetylhexosamine (HexNAc).	N-Acetylneuraminic Acid	113-136	serpin family F member 1	Homo sapiens	52-56
11867604-11	2002	LC-ESMS analysis of tryptic peptides indicated that PEDF A and B exhibit differences in glycopeptides containing N-acetylneuraminic acid (NeuAc) and N-acetylhexosamine (HexNAc).	N-Acetylneuraminic Acid	138-143	serpin family F member 1	Homo sapiens	52-56
11751912-4	2002	We added 16 synthetic sialic acid analogues carrying distinct C-1, C-5, or C-9 substitutions individually to cell cultures of which 10 were readily taken up and incorporated.	N-Acetylneuraminic Acid	22-33	T cell receptor gamma constant 1	Homo sapiens	62-65
11751912-4	2002	We added 16 synthetic sialic acid analogues carrying distinct C-1, C-5, or C-9 substitutions individually to cell cultures of which 10 were readily taken up and incorporated.	N-Acetylneuraminic Acid	22-33	complement C5	Homo sapiens	67-70
11751912-4	2002	We added 16 synthetic sialic acid analogues carrying distinct C-1, C-5, or C-9 substitutions individually to cell cultures of which 10 were readily taken up and incorporated.	N-Acetylneuraminic Acid	22-33	complement C9	Homo sapiens	75-78
11839290-1	2002	The addition of sialic acid to O-linked glycans of the T-cell co-receptor CD8 is regulated during thymocyte differentiation.	N-Acetylneuraminic Acid	16-27	CD8a molecule	Homo sapiens	55-73
11839290-1	2002	The addition of sialic acid to O-linked glycans of the T-cell co-receptor CD8 is regulated during thymocyte differentiation.	N-Acetylneuraminic Acid	16-27	CD8a molecule	Homo sapiens	74-77
11870229-8	2002	The acidic isoforms between pI values 5-6 appear to be related chemically to the more neutral isoforms by sialic acid residues since neuraminidase treatment converted the former into the latter isoforms.	N-Acetylneuraminic Acid	106-117	neuraminidase 1	Homo sapiens	133-146
11828253-1	2002	CD43, the major transmembrane sialoglycoprotein of neutrophils, monocytes, T lymphocytes and platelets, is highly glycosylated and its high sialic acid content contributes to the strongly negative charge of cells.	N-Acetylneuraminic Acid	140-151	sialophorin	Mus musculus	0-4
11886840-0	2002	Expression of a functional Drosophila melanogaster N-acetylneuraminic acid (Neu5Ac) phosphate synthase gene: evidence for endogenous sialic acid biosynthetic ability in insects.	N-Acetylneuraminic Acid	133-144	N-acetylneuraminic acid synthase	Drosophila melanogaster	76-82
11826157-9	2002	In summary, the gating of two human sodium channel isoforms show very different dependencies on sialic acid, with hSkM1 gating uniformly altered by sialic acid levels through an apparent electrostatic mechanism, while hH1 gating is unaffected by changing sialylation.	N-Acetylneuraminic Acid	96-107	sodium voltage-gated channel alpha subunit 4	Homo sapiens	114-119
11826157-9	2002	In summary, the gating of two human sodium channel isoforms show very different dependencies on sialic acid, with hSkM1 gating uniformly altered by sialic acid levels through an apparent electrostatic mechanism, while hH1 gating is unaffected by changing sialylation.	N-Acetylneuraminic Acid	96-107	H1.5 linker histone, cluster member	Homo sapiens	218-221
11826157-9	2002	In summary, the gating of two human sodium channel isoforms show very different dependencies on sialic acid, with hSkM1 gating uniformly altered by sialic acid levels through an apparent electrostatic mechanism, while hH1 gating is unaffected by changing sialylation.	N-Acetylneuraminic Acid	148-159	sodium voltage-gated channel alpha subunit 4	Homo sapiens	114-119
11826157-9	2002	In summary, the gating of two human sodium channel isoforms show very different dependencies on sialic acid, with hSkM1 gating uniformly altered by sialic acid levels through an apparent electrostatic mechanism, while hH1 gating is unaffected by changing sialylation.	N-Acetylneuraminic Acid	148-159	H1.5 linker histone, cluster member	Homo sapiens	218-221
11803561-3	2002	From a set of glycoproteins with known oligosaccharide structures, only asialofetuin and ovalbumin showed inhibitory activity, indicating that ovalbumin may block high affinity binding sites (IC(50) congruent with 1.3 microM) and asialofetuin low affinity sites (IC(50) congruent with 18 microM) of the complementary receptor systems, whereas fetuin carrying terminal sialic acid has no effect.	N-Acetylneuraminic Acid	368-379	ovalbumin	Sus scrofa	143-152
11826157-10	2002	Sialic acid-dependent gating can be removed or created by replacing or inserting hSkM1 IS5-S6, respectively, indicating that the functionally relevant sialic acid residues are localized to the first domain of the channel.	N-Acetylneuraminic Acid	0-11	sodium voltage-gated channel alpha subunit 4	Homo sapiens	81-86
12362990-6	2002	SNA-I lectin, recognizing alpha2-6 linked Neu5Ac residues, showed relatively weak reaction with native and only residual reaction with desialylated GPA samples.	N-Acetylneuraminic Acid	42-48	immunoglobulin binding protein 1	Homo sapiens	26-34
11916278-4	2002	To understand this we have characterized circulating SHBG isoforms according to their sialic acid content, which determines its half-life, in euthyroid and hypothyroid women.	N-Acetylneuraminic Acid	86-97	sex hormone binding globulin	Homo sapiens	53-57
11779119-0	2002	An improved fluorometric high-performance liquid chromatography method for sialic acid determination: an internal standard method and its application to sialic acid analysis of human apolipoprotein E.	N-Acetylneuraminic Acid	75-86	apolipoprotein E	Homo sapiens	183-199
11779119-0	2002	An improved fluorometric high-performance liquid chromatography method for sialic acid determination: an internal standard method and its application to sialic acid analysis of human apolipoprotein E.	N-Acetylneuraminic Acid	153-164	apolipoprotein E	Homo sapiens	183-199
11779119-7	2002	Using this method, the sialic acid content of human apolipoprotein E was successfully determined.	N-Acetylneuraminic Acid	23-34	apolipoprotein E	Homo sapiens	52-68
11835525-12	2002	The alpha(2,6)-linked sialic acid content in lambda-IgA1 (300-825 kDa) and kappa-IgA1 (150-610 kDa) from patients was also higher than that of controls.	N-Acetylneuraminic Acid	22-33	immunoglobulin heavy constant alpha 1	Homo sapiens	52-56
11754731-7	2002	Carbohydrate analyses of the purified mucin showed the presence of galactose, glucosamine, galactosamine, and sialic acid, but no mannose, glucose, or uronic acid.	N-Acetylneuraminic Acid	110-121	LOC100508689	Homo sapiens	38-43
11835525-14	2002	The negative charge from sialic acid may also favor mesangial deposition of macromolecular lambda-IgA1 in IgAN.	N-Acetylneuraminic Acid	25-36	IGAN1	Homo sapiens	106-110
12545205-10	2002	In addition, N-cadherin from WM9 (lymphomodus metastatic site) and A375 (solid tumor metastatic site) contained complex type chains with alpha2-3 sialic acid (positive reaction with Maackia amurensis agglutinin--MAA).	N-Acetylneuraminic Acid	146-157	cadherin 2	Homo sapiens	13-23
11835525-12	2002	The alpha(2,6)-linked sialic acid content in lambda-IgA1 (300-825 kDa) and kappa-IgA1 (150-610 kDa) from patients was also higher than that of controls.	N-Acetylneuraminic Acid	22-33	immunoglobulin heavy constant alpha 1	Homo sapiens	81-85
11835525-13	2002	This unusual glycosylation and sialylation pattern of the lambda-IgA1 may have important implications for the pathogenesis of IgAN, as both the masking effect of sialic acid on galactose and the reduced galactosylation will hinder the clearance of macromolecular lambda-IgA1 by asialoglycoprotein receptor of hepatocytes.	N-Acetylneuraminic Acid	162-173	immunoglobulin heavy constant alpha 1	Homo sapiens	65-69
11835525-13	2002	This unusual glycosylation and sialylation pattern of the lambda-IgA1 may have important implications for the pathogenesis of IgAN, as both the masking effect of sialic acid on galactose and the reduced galactosylation will hinder the clearance of macromolecular lambda-IgA1 by asialoglycoprotein receptor of hepatocytes.	N-Acetylneuraminic Acid	162-173	IGAN1	Homo sapiens	126-130
11835525-14	2002	The negative charge from sialic acid may also favor mesangial deposition of macromolecular lambda-IgA1 in IgAN.	N-Acetylneuraminic Acid	25-36	immunoglobulin heavy constant alpha 1	Homo sapiens	98-102
12053033-6	2002	The above findings show that sialic acid accounts for about 15-20% of the involvement of OPN in CaOx crystallization.	N-Acetylneuraminic Acid	29-40	secreted phosphoprotein 1	Homo sapiens	89-92
12091611-3	2002	The endogenous erythropoietin molecule may contain anything from 4 to 14 sialic acid residues.	N-Acetylneuraminic Acid	73-84	erythropoietin	Homo sapiens	15-29
11705914-7	2001	Further analysis revealed that the M protein binds to the sialic acid moieties on mucin, and this interaction seems to be based on M-protein conformation rather than specific amino acid sequences.	N-Acetylneuraminic Acid	58-69	myomesin 2	Homo sapiens	35-44
11755951-11	2001	A positive correlation was found between fibrinogen and SA levels (r=.5, P&lt;.01).	N-Acetylneuraminic Acid	56-58	fibrinogen beta chain	Homo sapiens	41-51
27264466-8	2001	Sialic acid suppressed ADP induced platelet aggregation and P-selectin expression in a dose dependent manner.	N-Acetylneuraminic Acid	0-11	selectin P	Homo sapiens	60-70
27264466-9	2001	In cryopreserved samples, P-selectin expression of 4 mg/mL sialic acid containing group was found significantly higher than the control group (p&lt; 0.001).	N-Acetylneuraminic Acid	59-70	selectin P	Homo sapiens	26-36
11913788-2	2001	The function of podocalyxin is unknown, but it contains most of the protein bound sialic acid in the glomerulus and is considered vital in the structure and function of the glomerular filtration apparatus.	N-Acetylneuraminic Acid	82-93	podocalyxin-like	Mus musculus	16-27
11705914-7	2001	Further analysis revealed that the M protein binds to the sialic acid moieties on mucin, and this interaction seems to be based on M-protein conformation rather than specific amino acid sequences.	N-Acetylneuraminic Acid	58-69	LOC100508689	Homo sapiens	82-87
11705914-7	2001	Further analysis revealed that the M protein binds to the sialic acid moieties on mucin, and this interaction seems to be based on M-protein conformation rather than specific amino acid sequences.	N-Acetylneuraminic Acid	58-69	myomesin 2	Homo sapiens	131-140
11705914-8	2001	We found that sialic acid also plays a critical role in the adherence of an M6 streptococcal strain to the Detroit 562 human pharyngeal cell line and have identified alpha2-6-linked sialic acid as an important sialylated linkage for M-protein recognition.	N-Acetylneuraminic Acid	14-25	myomesin 2	Homo sapiens	233-242
11705914-8	2001	We found that sialic acid also plays a critical role in the adherence of an M6 streptococcal strain to the Detroit 562 human pharyngeal cell line and have identified alpha2-6-linked sialic acid as an important sialylated linkage for M-protein recognition.	N-Acetylneuraminic Acid	182-193	myomesin 2	Homo sapiens	233-242
11705914-10	2001	The results are the first to show that sialic acid not only is involved in the binding of the streptococci to mucin but also plays an important role in adherence of group A streptococci to the pharyngeal cell surface.	N-Acetylneuraminic Acid	39-50	mucin 1, cell surface associated	Bos taurus	110-115
11746676-0	2001	Computational 3-D modeling and site-directed mutation of an antibody that binds Neu2en5Ac, a transition state analogue of a sialic acid.	N-Acetylneuraminic Acid	124-135	neuraminidase 2	Homo sapiens	80-84
11557751-3	2001	We investigated the effects of cholesterol and sialic acid depletion on Abeta-induced GTPase activity in cells, a step implicated in the mechanism of Abeta toxicity, and Abeta-induced cell toxicity.	N-Acetylneuraminic Acid	47-58	amyloid beta precursor protein	Rattus norvegicus	72-77
11557751-5	2001	In addition, cholesterol and membrane-associated sialic acid residue depletion or inhibition of cholesterol and ganglioside synthesis protected PC12 cells from Abeta-induced toxicity.	N-Acetylneuraminic Acid	49-60	amyloid beta precursor protein	Rattus norvegicus	160-165
11557751-3	2001	We investigated the effects of cholesterol and sialic acid depletion on Abeta-induced GTPase activity in cells, a step implicated in the mechanism of Abeta toxicity, and Abeta-induced cell toxicity.	N-Acetylneuraminic Acid	47-58	amyloid beta precursor protein	Rattus norvegicus	150-155
11557751-4	2001	Cholesterol reduction and depletion of membrane-associated sialic acid residues both significantly reduced the Abeta-induced GTPase activity.	N-Acetylneuraminic Acid	59-70	amyloid beta precursor protein	Rattus norvegicus	111-116
11839462-0	2001	Plasma sialic-acid index of apolipoprotein J (SIJ): a new alcohol intake marker.	N-Acetylneuraminic Acid	7-18	clusterin	Homo sapiens	28-44
11839462-4	2001	Because the sialic-acid index of Apo J (SIJ; moles of sialic acid per mole of Apo J protein) is approximately seven times more than that for transferrin (28 vs. 4), we have evaluated whether plasma SIJ would be an even more sensitive marker for chronic ethanol consumption than CDT in both rats and human subjects.	N-Acetylneuraminic Acid	12-23	clusterin	Rattus norvegicus	33-38
11839462-6	2001	We have found that chronic ethanol feeding resulted in loss of sialic acid residues of plasma HDL-Apo J in rats.	N-Acetylneuraminic Acid	63-74	clusterin	Rattus norvegicus	98-103
11839462-8	2001	In human subjects, an intake of about 60 g of alcohol for 30 days led to almost 50% (P &lt;.01) depletion of sialic acid from plasma HDL-Apo J.	N-Acetylneuraminic Acid	109-120	clusterin	Homo sapiens	137-142
11689212-9	2001	Serum trans-sialidase transferred sialic acid from glycoconjugates of plasma proteins (fetuin, transferrin) and gangliosides (GM3, GD3, GM1, GD1a, GD1b).	N-Acetylneuraminic Acid	34-45	transferrin	Homo sapiens	95-106
11689212-9	2001	Serum trans-sialidase transferred sialic acid from glycoconjugates of plasma proteins (fetuin, transferrin) and gangliosides (GM3, GD3, GM1, GD1a, GD1b).	N-Acetylneuraminic Acid	34-45	GRDX	Homo sapiens	131-134
11546777-2	2001	We report here a human Siglec-like molecule (Siglec-L1) that lacks a conserved arginine residue known to be essential for optimal sialic acid recognition by previously known Siglecs.	N-Acetylneuraminic Acid	130-141	SIGLEC family like 1	Homo sapiens	45-54
11546777-4	2001	The chimpanzee Siglec-L1 ortholog remains fully functional and preferentially recognizes N-glycolylneuraminic acid, which is a common sialic acid in great apes and other mammals.	N-Acetylneuraminic Acid	134-145	LOW QUALITY PROTEIN: SIGLEC family-like protein 1	Pan troglodytes	15-24
11598302-3	2001	Inhibition occurs through a metabolic mechanism in which ManBut is converted to unnatural sialic acid derivatives that effectively act as chain terminators during cellular PSA biosynthesis.	N-Acetylneuraminic Acid	90-101	aminopeptidase puromycin sensitive	Homo sapiens	172-175
11690653-1	2001	The CMP-Neu5Ac:Galbeta1-3GalNAc alpha2,3-sialyltransferase (ST3Gal I, EC 2.4.99.4) is a Golgi membrane-bound type II glycoprotein that catalyses the transfer of sialic acid residues to Galbeta1-3GalNAc disaccharide structures found on O-glycans and glycolipids.	N-Acetylneuraminic Acid	161-172	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	4-58
11690653-1	2001	The CMP-Neu5Ac:Galbeta1-3GalNAc alpha2,3-sialyltransferase (ST3Gal I, EC 2.4.99.4) is a Golgi membrane-bound type II glycoprotein that catalyses the transfer of sialic acid residues to Galbeta1-3GalNAc disaccharide structures found on O-glycans and glycolipids.	N-Acetylneuraminic Acid	161-172	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	60-68
11948856-3	2001	Our initial studies in this effort produce single-chain Fab sequences and dodecapeptides that bind to sialic acid and KDO with nanomolar and high micromolar affinity.	N-Acetylneuraminic Acid	102-113	FA complementation group B	Homo sapiens	56-59
11590221-7	2001	We suggest that macrophage-derived PAF-AH contains heterogeneous asparagine-conjugated sugar chain(s) involving sialic acid, which hinders its association with HDL but does not influence the secretion, catalytic activity, or resistance of PAF-AH to proteases.	N-Acetylneuraminic Acid	112-123	phospholipase A2 group VII	Homo sapiens	35-41
11589708-1	2001	The sialic acid N-glycolylneuraminic acid (Neu5Gc) is synthesized by the action of CMP-Neu5Ac hydroxylase.	N-Acetylneuraminic Acid	4-15	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	83-105
11683959-7	2001	Interestingly, immunoblot staining was enhanced after neuraminidase treatment, suggesting that the antibody epitope might also be partially masked by sialic acid.	N-Acetylneuraminic Acid	150-161	neuraminidase 1	Homo sapiens	54-67
11669356-6	2001	We believe that the multiple neuroendocrine disorder may be the consequence of the abnormalities of common neuronal pathways regulating growth hormone and gonadotropin synthesis or secretion related to the brain storage of free sialic acid and/or to the neurodegenerative process occurring in Salla disease.	N-Acetylneuraminic Acid	228-239	growth hormone 1	Homo sapiens	136-150
12441670-2	2001	Lubricin (M(r) approximately 240 kDa) is a mucinous glycoprotein which is 50% (w/w) post-translationally modified with beta(1-3)Gal-GalNAc incompletely capped with NeuAc, and lubricates apposed cartilaginous surfaces in the boundary mode through an unknown mechanism.	N-Acetylneuraminic Acid	164-169	proteoglycan 4	Homo sapiens	0-8
11591127-6	2001	This inhibition was blocked when a MAG monoclonal antibody was included in the gel and a control chimera sialoadhesin-Fc (Sn-Fc), which, like MAG, binds neurons in a sialic acid-dependent manner but does not inhibit axonal growth, had no effect.	N-Acetylneuraminic Acid	166-177	myelin-associated glycoprotein	Mus musculus	35-38
11780756-6	2001	Incubation of cells with the inhibitor of O-glycosylation benzyl-alpha-GaINAc reduced the molecular weight of osteopontin by blocking sialic acid addition to O-glycans.	N-Acetylneuraminic Acid	134-145	secreted phosphoprotein 1	Canis lupus familiaris	110-121
11518779-8	2001	Patients with IgAN displayed increased levels of IgA glycoforms exposing sialic acid in alpha2,6 linkage with N-acetylgalactosamine (Neu5Acalpha2,6GalNAc) (P &lt; 0.02) and GalNAc (P &lt; 0.05), indicating truncation of O-linked glycans of IgA1.	N-Acetylneuraminic Acid	73-84	IGAN1	Homo sapiens	14-18
11518779-8	2001	Patients with IgAN displayed increased levels of IgA glycoforms exposing sialic acid in alpha2,6 linkage with N-acetylgalactosamine (Neu5Acalpha2,6GalNAc) (P &lt; 0.02) and GalNAc (P &lt; 0.05), indicating truncation of O-linked glycans of IgA1.	N-Acetylneuraminic Acid	73-84	immunoglobulin heavy constant alpha 1	Homo sapiens	240-244
11358961-0	2001	Cloning and characterization of Siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells.	N-Acetylneuraminic Acid	51-62	sialic acid binding Ig like lectin 10	Homo sapiens	32-41
11595162-1	2001	GM3 synthase, which transfers CMP-NeuAc with an alpha2,3-linkage to a galactose residue of lactosylceramide, plays a key role in the biosynthesis of all complex gangliosides.	N-Acetylneuraminic Acid	34-39	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	0-12
11462020-3	2001	We reported previously that 4-guanidino-neu5Ac2en (4-GU-DANA) and related sialic acid-based inhibitors of HPF3 neuraminidase activity also inhibit HN-mediated receptor binding and fusion processes not involving neuraminidase activity.	N-Acetylneuraminic Acid	74-85	zinc finger protein 17	Homo sapiens	106-110
11462020-3	2001	We reported previously that 4-guanidino-neu5Ac2en (4-GU-DANA) and related sialic acid-based inhibitors of HPF3 neuraminidase activity also inhibit HN-mediated receptor binding and fusion processes not involving neuraminidase activity.	N-Acetylneuraminic Acid	74-85	neuraminidase 1	Homo sapiens	111-124
11462020-3	2001	We reported previously that 4-guanidino-neu5Ac2en (4-GU-DANA) and related sialic acid-based inhibitors of HPF3 neuraminidase activity also inhibit HN-mediated receptor binding and fusion processes not involving neuraminidase activity.	N-Acetylneuraminic Acid	74-85	neuraminidase 1	Homo sapiens	211-224
11467948-6	2001	The heterogeneous N-linked oligosaccharides of TNFR-IgG contain sialic acid (Sia), Gal, and GlcNAc as terminal sugar residues.	N-Acetylneuraminic Acid	64-75	TNF receptor superfamily member 1A	Homo sapiens	47-51
11467948-6	2001	The heterogeneous N-linked oligosaccharides of TNFR-IgG contain sialic acid (Sia), Gal, and GlcNAc as terminal sugar residues.	N-Acetylneuraminic Acid	77-80	TNF receptor superfamily member 1A	Homo sapiens	47-51
11467948-9	2001	Similar treatment of TNFR-IgG with alpha2,3ST and CMP-sialic acid (CMP-Sia), in the presence of MnCl(2), produced a molecule with an approximately 11% increase in the level of terminal sialylation but still contained oligosaccharides with terminal GlcNAc residues.	N-Acetylneuraminic Acid	54-65	TNF receptor superfamily member 1A	Homo sapiens	21-25
11358961-9	2001	When expressed on COS-7 cells, Siglec-10 was able to bind human red blood cells and soluble sialoglycoconjugates in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	118-129	sialic acid binding Ig like lectin 10	Homo sapiens	31-40
11358961-10	2001	The identification of Siglec-10 as a new Siglec family member and its expression profile, together with its sialic acid-dependent binding capacity, suggest that it may be involved in cell-cell recognition by interacting with sialylated ligands expressed on specific cell populations.	N-Acetylneuraminic Acid	108-119	sialic acid binding Ig like lectin 10	Homo sapiens	22-31
11394903-4	2001	Kinetic analysis shows that it is a CMP-Neu5Ac competitive inhibitor with for ST3Gal I with an inhibition constant (K(i)) of 2.1 microM.	N-Acetylneuraminic Acid	40-46	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	78-86
11522397-2	2001	Myelin associated glycoprotein (MAG), a minor constituent of myelin, is a sialic acid binding lectin with two established physiological functions: it is involved in myelin-axon stability and cytoarchitecture, and controls nerve regeneration.	N-Acetylneuraminic Acid	74-85	myelin-associated glycoprotein	Mus musculus	0-30
11522397-2	2001	Myelin associated glycoprotein (MAG), a minor constituent of myelin, is a sialic acid binding lectin with two established physiological functions: it is involved in myelin-axon stability and cytoarchitecture, and controls nerve regeneration.	N-Acetylneuraminic Acid	74-85	myelin-associated glycoprotein	Mus musculus	32-35
11522397-10	2001	Furthermore, removal of NeuAc residues from nerve cells reverses MAG-mediated inhibition of neuritogenesis, and neurons from mice lacking the "NeuAc alpha 3 Gal beta 3GalNAc" terminus have an attenuated response to MAG.	N-Acetylneuraminic Acid	24-29	myelin-associated glycoprotein	Mus musculus	65-68
11454199-2	2001	The EBA175 protein of P. falciparum has been shown to be the ligand that binds to a sialic acid-dependent site on glycophorin A.	N-Acetylneuraminic Acid	84-95	glycophorin A (MNS blood group)	Homo sapiens	114-127
11283023-0	2001	The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth.	N-Acetylneuraminic Acid	40-51	CD24 molecule	Homo sapiens	71-75
11485761-1	2001	PURPOSE: We measured the concentration of sialic acid, the terminal component of mucin, in normal diluted human tears.	N-Acetylneuraminic Acid	42-53	LOC100508689	Homo sapiens	81-86
11328818-1	2001	We describe the molecular cloning and characterization of S2V, a novel sialic acid binding immunoglobulin-like lectin.	N-Acetylneuraminic Acid	71-82	sialic acid binding Ig like lectin 12	Homo sapiens	58-61
11328818-3	2001	A unique feature of S2V is the presence of two V-set Ig-like domains responsible for the binding to sialic acid, whereas all other known siglecs possess only one.	N-Acetylneuraminic Acid	100-111	sialic acid binding Ig like lectin 12	Homo sapiens	20-23
11328818-8	2001	When expressed in COS-7 cells, S2V was able to mediate sialic acid-dependent binding to human red blood cells, suggesting that S2V may function through cell-cell interaction.	N-Acetylneuraminic Acid	55-66	sialic acid binding Ig like lectin 12	Homo sapiens	31-34
11328818-8	2001	When expressed in COS-7 cells, S2V was able to mediate sialic acid-dependent binding to human red blood cells, suggesting that S2V may function through cell-cell interaction.	N-Acetylneuraminic Acid	55-66	sialic acid binding Ig like lectin 12	Homo sapiens	127-130
11279053-3	2001	MAG has a sialic acid binding site in its N-terminal domain and binds to specific sialylated glycans and gangliosides present on the surface of neurons, but the significance of these interactions in the effect of MAG on neurite outgrowth is unclear.	N-Acetylneuraminic Acid	10-21	myelin associated glycoprotein	Homo sapiens	0-3
11279053-5	2001	Arginine 118 on MAG is known to make a key contact with sialic acid.	N-Acetylneuraminic Acid	56-67	myelin associated glycoprotein	Homo sapiens	16-19
11925509-1	2001	Apoptosis in B cells is induced through the B cell antigen receptor (BCR) and affects the sialic acid recognition molecules on B cells.	N-Acetylneuraminic Acid	90-101	BCR activator of RhoGEF and GTPase	Homo sapiens	44-73
11325539-0	2001	Effects of sialic acid residues of transferrin on the binding with aluminum and iron studied by HPLC/high-resolution ICP-MS. Transferrins (Tfs) are glycoproteins with carbohydrate chains in the C-lobe.	N-Acetylneuraminic Acid	11-22	transferrin	Homo sapiens	35-46
11925509-6	2001	These contradictory results suggested that the recognition molecules for alpha2,6-linked sialic acid on AGP, which inhibits B-cell apoptosis, is distinct from CD22, or that different binding domains of CD22 between alpha2,6-linked sialic acid and anti-CD22 mAb exert opposite functions of suppression or enhancement to anti-IgM Ab-induced B cells.	N-Acetylneuraminic Acid	231-242	CD22 molecule	Homo sapiens	202-206
11925509-6	2001	These contradictory results suggested that the recognition molecules for alpha2,6-linked sialic acid on AGP, which inhibits B-cell apoptosis, is distinct from CD22, or that different binding domains of CD22 between alpha2,6-linked sialic acid and anti-CD22 mAb exert opposite functions of suppression or enhancement to anti-IgM Ab-induced B cells.	N-Acetylneuraminic Acid	231-242	CD22 molecule	Homo sapiens	202-206
11425801-1	2001	The sialyltransferase ST6Gal mediates the biosynthetic addition of sialic acid, via an alpha2,6 linkage, to the nonreducing end of terminal lactosamine structures.	N-Acetylneuraminic Acid	67-78	beta galactoside alpha 2,6 sialyltransferase 1	Mus musculus	22-28
11465673-6	2001	However, the sialicacid polymer colominic acid inhibited anti-GD2 and anti-GD3, but not anti-CD60 from binding to cell surfaces.	N-Acetylneuraminic Acid	13-23	GRDX	Homo sapiens	75-78
11278955-1	2001	We describe the molecular cloning and characterization of a novel myeloid inhibitory siglec, MIS, that belongs to the family of sialic acid-binding immunoglobulin-like lectins.	N-Acetylneuraminic Acid	128-139	anti-Mullerian hormone	Homo sapiens	93-96
11313386-10	2001	Multiple sequence alignments revealed the presence of this TxYxxV/I motif not only in CD2 subfamily members but also in the cytoplasmic domains of the members of the SHP-2 substrate 1, sialic acid-binding Ig-like lectin, carcinoembryonic Ag, and leukocyte-inhibitory receptor families.	N-Acetylneuraminic Acid	185-196	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	166-171
11506181-1	2001	In the present study, we have observed that sialic acid binding protein (SABP - a 54 kDa glycoprotein which was isolated from human endometrial scrapings taken at various stages of the menstrual cycle from normal cycling females and purified to apparent homogeneity and was earlier reported from this laboratory) was found in sufficiently detectable amount in the endometrium of normal cycling women whereas it was found in lesser amount in tissue from women who have recently entered the postmenopause stage.	N-Acetylneuraminic Acid	44-55	prolactin induced protein	Homo sapiens	73-77
11284735-4	2001	However, cells stably transfected with CMP-NeuAc:GM3 sialyltransferase and expressing GD3 at the cell surface showed both decreased EGFr phosphorylation and ERK2 activation after stimulation with EGF.	N-Acetylneuraminic Acid	43-48	epidermal growth factor receptor	Cricetulus griseus	132-136
11152460-1	2001	B-cell-specific CD22 is a member of a group of cell adhesion molecules within the immunoglobulin superfamily that display binding to glycans with terminal sialic acid residues.	N-Acetylneuraminic Acid	155-166	CD22 molecule	Homo sapiens	16-20
11322763-5	2001	We found that the half-life of the highly sialylated CEACAM1 is increased from 26 to 40 h by replacement of the N-acetylneuraminic acid by the novel, engineered N-propanoylneuraminic acids, whereas the half-life of the alpha1-integrin subunit remains unaffected under the same conditions.	N-Acetylneuraminic Acid	112-135	CEA cell adhesion molecule 1	Homo sapiens	53-60
11398988-2	2001	After incubation of the sialyltransferase reaction, the sialyloligosaccharide obtained was treated by acid hydrolysis, and then the NeuAc that was released was labeled with 1,2-diamino-4,5-methylenedioxibenzene.	N-Acetylneuraminic Acid	132-137	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	24-41
11284727-4	2001	Pg 2 has six glycoforms that differ in their sialic acid content.	N-Acetylneuraminic Acid	45-56	delta like non-canonical Notch ligand 1	Homo sapiens	0-4
11284738-1	2001	Here we characterize Siglec-10 as a new member of the Siglec family of sialic acid-binding Ig-like lectins.	N-Acetylneuraminic Acid	71-82	sialic acid binding Ig like lectin 10	Homo sapiens	21-30
11238599-4	2001	Binding of sialoadhesin to these glycoproteins was sialic acid dependent and was abolished by mutation of a critical residue (R97A) of the sialic acid binding site in the membrane distal Ig-like domain of sialoadhesin.	N-Acetylneuraminic Acid	51-62	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	11-23
11118434-2	2001	We have analyzed whether competition by the glycosyltransferase, ST3Gal-I, which transfers sialic acid to galactose in the core 1 substrate, is key to this switch in MUC1 glycosylation that results in the expression of the cancer-associated SM3 epitope.	N-Acetylneuraminic Acid	91-102	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	65-73
11118434-2	2001	We have analyzed whether competition by the glycosyltransferase, ST3Gal-I, which transfers sialic acid to galactose in the core 1 substrate, is key to this switch in MUC1 glycosylation that results in the expression of the cancer-associated SM3 epitope.	N-Acetylneuraminic Acid	91-102	mucin 1, cell surface associated	Homo sapiens	166-170
11282022-5	2001	In these cells, DPP-IV and CD44 lost the sialic acid residue substituting the O-linked core 1 structure Galbeta1-3GalNAc (T-antigen).	N-Acetylneuraminic Acid	41-52	dipeptidyl peptidase 4	Homo sapiens	16-22
11282022-5	2001	In these cells, DPP-IV and CD44 lost the sialic acid residue substituting the O-linked core 1 structure Galbeta1-3GalNAc (T-antigen).	N-Acetylneuraminic Acid	41-52	CD44 molecule (Indian blood group)	Homo sapiens	27-31
11264365-0	2001	Adaptation of influenza A viruses to cells expressing low levels of sialic acid leads to loss of neuraminidase activity.	N-Acetylneuraminic Acid	68-79	neuraminidase 1	Homo sapiens	97-110
11238630-10	2001	We conclude that CD83 is an adhesion receptor with a counterreceptor expressed on monocytes and a subset of activated or stressed T lymphocytes, and that interaction between CD83 and its counterreceptor is dependent upon the state of glycosylation of a 72-kDa counterreceptor by sialic acid residues.	N-Acetylneuraminic Acid	279-290	CD83 molecule	Homo sapiens	17-21
11238630-10	2001	We conclude that CD83 is an adhesion receptor with a counterreceptor expressed on monocytes and a subset of activated or stressed T lymphocytes, and that interaction between CD83 and its counterreceptor is dependent upon the state of glycosylation of a 72-kDa counterreceptor by sialic acid residues.	N-Acetylneuraminic Acid	279-290	CD83 molecule	Homo sapiens	174-178
11308268-1	2001	Studies on human erythropoietin (EPO) demonstrated that there is a direct relationship between the sialic acid-containing carbohydrate content of the molecule and its serum half-life and in vivo biological activity, but an inverse relationship with its receptor-binding affinity.	N-Acetylneuraminic Acid	99-110	erythropoietin	Homo sapiens	17-31
11308268-1	2001	Studies on human erythropoietin (EPO) demonstrated that there is a direct relationship between the sialic acid-containing carbohydrate content of the molecule and its serum half-life and in vivo biological activity, but an inverse relationship with its receptor-binding affinity.	N-Acetylneuraminic Acid	99-110	erythropoietin	Homo sapiens	33-36
11308268-5	2001	Due to its increased sialic acid-containing carbohydrate content, NESP is biochemically distinct from rHuEPO, having an increased molecular weight and greater negative charge.	N-Acetylneuraminic Acid	21-32	GNAS complex locus	Homo sapiens	66-70
11308269-2	2001	Novel erythropoiesis stimulating protein (NESP, darbepoetin alfa) was created using site-directed mutagenesis to have 8 more sialic acid side chains than recombinant human erythropoietin (rHuEPO).	N-Acetylneuraminic Acid	125-136	GNAS complex locus	Homo sapiens	0-40
11308269-2	2001	Novel erythropoiesis stimulating protein (NESP, darbepoetin alfa) was created using site-directed mutagenesis to have 8 more sialic acid side chains than recombinant human erythropoietin (rHuEPO).	N-Acetylneuraminic Acid	125-136	GNAS complex locus	Homo sapiens	42-46
11308270-3	2001	NESP is biochemically distinct from rHuEPO, due to its increased sialic acid content.	N-Acetylneuraminic Acid	65-76	GNAS complex locus	Homo sapiens	0-4
11308271-2	2001	Novel erythropoiesis stimulating protein (NESP, darbepoetin alfa), a protein with additional sialic acid compared with erythropoietin (EPO), stimulates erythropoiesis by the same mechanism as recombinant human erythropoietin (rHuEPO) but it is biochemically distinct.	N-Acetylneuraminic Acid	93-104	GNAS complex locus	Homo sapiens	0-40
11308271-2	2001	Novel erythropoiesis stimulating protein (NESP, darbepoetin alfa), a protein with additional sialic acid compared with erythropoietin (EPO), stimulates erythropoiesis by the same mechanism as recombinant human erythropoietin (rHuEPO) but it is biochemically distinct.	N-Acetylneuraminic Acid	93-104	GNAS complex locus	Homo sapiens	42-46
11238599-4	2001	Binding of sialoadhesin to these glycoproteins was sialic acid dependent and was abolished by mutation of a critical residue (R97A) of the sialic acid binding site in the membrane distal Ig-like domain of sialoadhesin.	N-Acetylneuraminic Acid	51-62	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	205-217
11238599-4	2001	Binding of sialoadhesin to these glycoproteins was sialic acid dependent and was abolished by mutation of a critical residue (R97A) of the sialic acid binding site in the membrane distal Ig-like domain of sialoadhesin.	N-Acetylneuraminic Acid	139-150	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	11-23
11238599-4	2001	Binding of sialoadhesin to these glycoproteins was sialic acid dependent and was abolished by mutation of a critical residue (R97A) of the sialic acid binding site in the membrane distal Ig-like domain of sialoadhesin.	N-Acetylneuraminic Acid	139-150	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	205-217
11318072-8	2001	RESULTS: Zanamivir and oseltamivir inactivate viral neuraminidase, an enzyme responsible for cleaving sialic acid residues on newly formed virions as they bud off from the host cell.	N-Acetylneuraminic Acid	102-113	neuraminidase 1	Homo sapiens	52-65
11261727-3	2001	The attaching position of the sialic acid residue was determined using the linkage preference of neuraminidase isozymes.	N-Acetylneuraminic Acid	30-41	neuraminidase 1	Homo sapiens	97-110
11222633-1	2001	To investigate the tissue distribution and subcellular localization of ST3GalV (CMP-NeuAc:lactosylceramide alpha2,3 sialyltransferase/GM3 synthase) in the adult mouse, we generated two antisera against mouse ST3GalV that were designated CS2 (directed against amino acids K227-I272) and CS14 (directed against amino acids D308-H359).	N-Acetylneuraminic Acid	84-89	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Rattus norvegicus	71-78
11300473-7	2001	We have found that desialylated ASC-MUC1 was further glycosylated by peptidyl N-acetylgalactosamine transferases and was not when sialic acid was present.	N-Acetylneuraminic Acid	130-141	PYD and CARD domain containing	Homo sapiens	32-35
11300473-7	2001	We have found that desialylated ASC-MUC1 was further glycosylated by peptidyl N-acetylgalactosamine transferases and was not when sialic acid was present.	N-Acetylneuraminic Acid	130-141	mucin 1, cell surface associated	Homo sapiens	36-40
11342172-1	2001	We show that cell surface glycans, sialic acid and mannose-containing species, are involved beside glycosaminoglycans (GAGs), heparan sulfate and chondroitin sulfate in the binding of full length (1--68) RANTES not only to CCR5 positive human primary lymphocytes or macrophages but also to CCR5 negative monocytic U937 cells.	N-Acetylneuraminic Acid	35-46	C-C motif chemokine receptor 5	Homo sapiens	223-227
11251878-0	2001	New functions for the sialic acid-binding adhesion molecule CD22, a member of the growing family of Siglecs.	N-Acetylneuraminic Acid	22-33	CD22 molecule	Homo sapiens	60-64
11342264-9	2001	These results indicate that PSA-A and PSA-B differ not only in their sialic acid contents, but also in their outer chain features.	N-Acetylneuraminic Acid	69-80	fatty acid amide hydrolase	Homo sapiens	28-43
11170976-5	2001	These variants had a higher affinity for Neu5Ac(alpha2-6)Gal-containing receptors, which are characteristic of human respiratory epithelium, than for Neu5Ac(alpha2-3)Gal-containing receptors, which are typical of chicken egg allantoic membrane.	N-Acetylneuraminic Acid	41-47	immunoglobulin binding protein 1	Homo sapiens	48-56
11160731-8	2001	Thus, neuraminidase-sensitive strains bind to external sialic acid residues in gangliosides, while neuraminidase-insensitive strains recognize gangliosides with internal sialic acids, which are resistant to neuraminidase treatment.	N-Acetylneuraminic Acid	55-66	neuraminidase 1	Bos taurus	6-19
11342172-1	2001	We show that cell surface glycans, sialic acid and mannose-containing species, are involved beside glycosaminoglycans (GAGs), heparan sulfate and chondroitin sulfate in the binding of full length (1--68) RANTES not only to CCR5 positive human primary lymphocytes or macrophages but also to CCR5 negative monocytic U937 cells.	N-Acetylneuraminic Acid	35-46	C-C motif chemokine receptor 5	Homo sapiens	290-294
11171044-0	2001	mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2.	N-Acetylneuraminic Acid	46-57	sialic acid binding Ig-like lectin E	Mus musculus	0-9
11171044-0	2001	mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2.	N-Acetylneuraminic Acid	46-57	CD33 antigen	Mus musculus	25-29
11171044-0	2001	mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2.	N-Acetylneuraminic Acid	46-57	signal-regulatory protein alpha	Mus musculus	177-182
11171044-0	2001	mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2.	N-Acetylneuraminic Acid	46-57	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	187-192
11171044-7	2001	When expressed in COS-7 cells, mSiglec-E was able to mediate sialic acid-dependent binding to human red blood cells, suggesting that mSiglec-E may function through cell-cell interactions.	N-Acetylneuraminic Acid	61-72	sialic acid binding Ig-like lectin E	Mus musculus	31-40
11308020-11	2001	It was the activity of CMP-sialic acid:GalNAc-mucin alpha6-sialyltransferase that coincided with Sialyl-Tn expression.	N-Acetylneuraminic Acid	27-38	solute carrier family 13 member 2	Rattus norvegicus	46-51
11308027-0	2001	Biosynthesis of N-acetylneuraminic acid in cells lacking UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.	N-Acetylneuraminic Acid	16-39	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	57-119
11308027-1	2001	The first two steps in mammalian biosynthesis of N-acetylneuraminic acid, an important carbohydrate moiety in biological recognition systems, are performed by the bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase.	N-Acetylneuraminic Acid	49-72	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	183-245
11171044-7	2001	When expressed in COS-7 cells, mSiglec-E was able to mediate sialic acid-dependent binding to human red blood cells, suggesting that mSiglec-E may function through cell-cell interactions.	N-Acetylneuraminic Acid	61-72	sialic acid binding Ig-like lectin E	Mus musculus	133-142
11217952-0	2001	Synthesis of novel ganglioside GM4 analogues containing N-deacetylated and lactamized sialic acid: probes for searching new ligand structures for human L-selectin.	N-Acetylneuraminic Acid	86-97	selectin L	Homo sapiens	152-162
11419909-5	2001	Our data are in support of the view that the O-linked oligosaccharide moieties of the patients IgA1 were generally lacking in galactose and sialic acid residues.	N-Acetylneuraminic Acid	140-151	immunoglobulin heavy constant alpha 1	Homo sapiens	95-99
11680873-3	2001	Glycophorin A which is the major carrier of erythrocyte sialic acid, was deficient in N-acetylgalactosamine, and sialic acid residues.	N-Acetylneuraminic Acid	56-67	glycophorin A (MNS blood group)	Homo sapiens	0-13
11680873-3	2001	Glycophorin A which is the major carrier of erythrocyte sialic acid, was deficient in N-acetylgalactosamine, and sialic acid residues.	N-Acetylneuraminic Acid	113-124	glycophorin A (MNS blood group)	Homo sapiens	0-13
11166807-1	2001	Introduction of beta-galactosidase into a trans-sialidase reaction, i.e. sialic acid transfer reaction from a donor substrate (alpha2,3-sialyllactose) to an acceptor substrate (beta-galactosyldisaccharide), could improve the yield of desired sialylated trisaccharide by hydrolyzing lactose, a byproduct from the donor.	N-Acetylneuraminic Acid	73-84	galactosidase beta 1	Homo sapiens	16-34
11272271-2	2001	We previously described the intracellular and cell-surface expression of the CD24 sialic acid-dependent epitope(s) on phytohemagglutinin-activated peripheral blood mononuclear cells.	N-Acetylneuraminic Acid	82-93	CD24 molecule	Homo sapiens	77-81
11115395-5	2001	For cells grown on collagen, the amount of the sialic-acid-rich mucin increased over 10 days, whereas the PAS-reactive component was largely absent after 24 h, which was consistent with an initial release of stored PAS-reactive molecules and synthesis of the sialic-acid-rich mucins de novo.	N-Acetylneuraminic Acid	47-58	mucin 1, cell surface associated	Bos taurus	64-69
11270179-11	2001	In milk, gangliosides, sialic acid-containing glycolipid, occur mainly as monosialoganglioside 3 (GM3) and disialoganglioside 3 (GD3).	N-Acetylneuraminic Acid	23-34	GRDX	Homo sapiens	129-132
11197350-10	2001	In the first stage, a series of monovalent NeuAc alpha-2,6-Glc(Y)X type binding motifs was prepared, and their affinity for murine CD22 was monitored, to obtain more insight into the effect of separate structure elements on ligand recognition.	N-Acetylneuraminic Acid	43-48	CD22 antigen	Mus musculus	131-135
11133773-1	2001	Sialoadhesin is a macrophage-restricted cellular interaction molecule and a prototypic member of the Siglec family of sialic acid binding immunoglobulin (Ig)-like lectins.	N-Acetylneuraminic Acid	118-129	sialic acid binding Ig like lectin 1	Homo sapiens	0-12
11133773-5	2001	A recombinant protein consisting of the first 4 N-terminal domains of human sialoadhesin fused to the Fc region of human IgG1 mediated sialic acid-dependent binding with a specificity similar to its mouse counterpart, preferring sialic acid in the alpha2,3 glycosidic linkage over the alpha2,6 linkage.	N-Acetylneuraminic Acid	135-146	sialic acid binding Ig like lectin 1	Homo sapiens	76-88
11197350-11	2001	In the second stage, we prepared a trivalent cluster, based on the monovalent motif that displayed the highest affinity for CD22, NeuAc alpha-2,6-GlcNBzNO2OMe (7).	N-Acetylneuraminic Acid	130-135	CD22 antigen	Mus musculus	124-128
11133773-5	2001	A recombinant protein consisting of the first 4 N-terminal domains of human sialoadhesin fused to the Fc region of human IgG1 mediated sialic acid-dependent binding with a specificity similar to its mouse counterpart, preferring sialic acid in the alpha2,3 glycosidic linkage over the alpha2,6 linkage.	N-Acetylneuraminic Acid	229-240	sialic acid binding Ig like lectin 1	Homo sapiens	76-88
11847413-2	2001	The deformability of cells was decreased by treating with diamide, diazene-dicarboxylic acid bis[N,N-dimethylamide], and the sialic acid content of cells, i.e., the surface negative charge, was reduced by treating with neuraminidase.	N-Acetylneuraminic Acid	125-136	neuraminidase 1	Homo sapiens	219-232
11588980-4	2001	About 20 systems for transporting small molecules across the lysosomal membrane have been characterized but only two proteins, cystinosin and sialin, involved in the transport of cystine and sialic acid, respectively, have been cloned.	N-Acetylneuraminic Acid	191-202	cystinosin, lysosomal cystine transporter	Homo sapiens	127-137
11588980-4	2001	About 20 systems for transporting small molecules across the lysosomal membrane have been characterized but only two proteins, cystinosin and sialin, involved in the transport of cystine and sialic acid, respectively, have been cloned.	N-Acetylneuraminic Acid	191-202	solute carrier family 17 member 5	Homo sapiens	142-148
11729980-11	2001	Substance containing sialic acid such as podocalyxin on the podocyte surface may be stained.	N-Acetylneuraminic Acid	21-32	podocalyxin-like	Rattus norvegicus	41-52
11255236-14	2001	The normal conversion of DBP to DBP-maf requires the selective removal of galactose and sialic acid from the third domain of the protein.	N-Acetylneuraminic Acid	88-99	D-box binding PAR bZIP transcription factor	Rattus norvegicus	25-28
11845303-2	2001	To test this hypothesis we compared expression of sulphate and sialic acid on three salivary mucins namely MG1 (MUC-5B), MG2 (MUC-7) and GL.	N-Acetylneuraminic Acid	63-74	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	107-110
11255236-14	2001	The normal conversion of DBP to DBP-maf requires the selective removal of galactose and sialic acid from the third domain of the protein.	N-Acetylneuraminic Acid	88-99	D-box binding PAR bZIP transcription factor	Rattus norvegicus	32-35
11135081-3	2001	It has been suggested that increased sialic acid content and anionic charge of the pIgA1 molecules may be operational in the IgA1 deposition in human mesangial cells (HMCs).	N-Acetylneuraminic Acid	37-48	MKKS centrosomal shuttling protein	Homo sapiens	167-171
11402085-1	2001	Studies on human erythropoietin (EPO) demonstrated that there is a direct relationship between the sialic acid-containing carbohydrate content of the molecule and its serum half-life and in vivo biological activity, but an inverse relationship with its receptor binding affinity.	N-Acetylneuraminic Acid	99-110	erythropoietin	Homo sapiens	17-31
11402085-1	2001	Studies on human erythropoietin (EPO) demonstrated that there is a direct relationship between the sialic acid-containing carbohydrate content of the molecule and its serum half-life and in vivo biological activity, but an inverse relationship with its receptor binding affinity.	N-Acetylneuraminic Acid	99-110	erythropoietin	Homo sapiens	33-36
11402085-5	2001	Due to its increased sialic acid-containing carbohydrate content, NESP is biochemically distinct from rHuEPO, having an increased molecular weight and greater negative charge.	N-Acetylneuraminic Acid	21-32	GNAS complex locus	Homo sapiens	66-70
11845304-7	2001	We found that each mucin shows a characteristic glycosylation pattern and in controls most of the sialic acid is 2--&gt;6 linked on MG1 (MUC 5B) and 2--&gt;3 linked on MG2 (MUC 7).	N-Acetylneuraminic Acid	98-109	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	132-135
11417114-5	2001	Viral neuraminidase (NA) cleaves the virus from host cell sialic acid residues allowing infection of other host cells.	N-Acetylneuraminic Acid	58-69	neuraminidase 1	Homo sapiens	6-19
11417114-5	2001	Viral neuraminidase (NA) cleaves the virus from host cell sialic acid residues allowing infection of other host cells.	N-Acetylneuraminic Acid	58-69	neuraminidase 1	Homo sapiens	21-23
11845304-7	2001	We found that each mucin shows a characteristic glycosylation pattern and in controls most of the sialic acid is 2--&gt;6 linked on MG1 (MUC 5B) and 2--&gt;3 linked on MG2 (MUC 7).	N-Acetylneuraminic Acid	98-109	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	137-143
11548210-5	2001	Viral neuraminidase (NA) cleaves the virus from host cell sialic acid residues allowing infection of other host cells.	N-Acetylneuraminic Acid	58-69	neuraminidase 1	Homo sapiens	6-19
11845304-7	2001	We found that each mucin shows a characteristic glycosylation pattern and in controls most of the sialic acid is 2--&gt;6 linked on MG1 (MUC 5B) and 2--&gt;3 linked on MG2 (MUC 7).	N-Acetylneuraminic Acid	98-109	mucin 7, secreted	Homo sapiens	173-178
11548210-5	2001	Viral neuraminidase (NA) cleaves the virus from host cell sialic acid residues allowing infection of other host cells.	N-Acetylneuraminic Acid	58-69	neuraminidase 1	Homo sapiens	21-23
11246506-3	2000	These differences in the amount of bound bilirubin to different membrane vesicles were correlated well with the percentage accessibility of sialic acid to neuraminidase in these membranes suggesting that bilirubin bound preferentially to the outer layer of erythrocyte membranes than the inner layer.	N-Acetylneuraminic Acid	140-151	neuraminidase 1	Homo sapiens	155-168
10978329-11	2000	These results reveal a stereospecific interaction of P-selectin with PSGL-1 that includes distinct contributions of each of the three TyrSO(3) residues, adjacent peptide determinants, and fucose/sialic acid on an optimally positioned core-2 O-glycan.	N-Acetylneuraminic Acid	195-206	selectin P	Homo sapiens	53-63
10978329-11	2000	These results reveal a stereospecific interaction of P-selectin with PSGL-1 that includes distinct contributions of each of the three TyrSO(3) residues, adjacent peptide determinants, and fucose/sialic acid on an optimally positioned core-2 O-glycan.	N-Acetylneuraminic Acid	195-206	selectin P ligand	Homo sapiens	69-75
11302201-5	2001	The main difference between haptoglobin derived from the sample of pooled 44 sera and from the 2-2 phenotype individual concerned the relative content of trisialylated oligosaccharide with one 2-3 linked sialic acid residue.	N-Acetylneuraminic Acid	204-215	haptoglobin	Homo sapiens	28-39
11114069-4	2000	ACE-ACE interaction was competitively inhibited by Neu5Ac- or Gal-terminated saccharides.	N-Acetylneuraminic Acid	51-57	angiotensin I converting enzyme	Homo sapiens	0-3
11159927-5	2000	Only IgG1-Pro-5 was sialylated with sialic acid present on only a small percentage of the carbohydrate structures.	N-Acetylneuraminic Acid	36-47	LOC105243590	Mus musculus	5-9
11066069-5	2000	The specific reactivity of P36 and P18 with WGA and AAL lectins, respectively, indicated the presence of lactosaminyl structures with sialic acid termini in P36 and of fucosylated residues in P18.	N-Acetylneuraminic Acid	134-145	5'-nucleotidase, cytosolic IIIA	Homo sapiens	27-30
11066069-5	2000	The specific reactivity of P36 and P18 with WGA and AAL lectins, respectively, indicated the presence of lactosaminyl structures with sialic acid termini in P36 and of fucosylated residues in P18.	N-Acetylneuraminic Acid	134-145	H3 histone pseudogene 12	Homo sapiens	35-38
11066069-5	2000	The specific reactivity of P36 and P18 with WGA and AAL lectins, respectively, indicated the presence of lactosaminyl structures with sialic acid termini in P36 and of fucosylated residues in P18.	N-Acetylneuraminic Acid	134-145	5'-nucleotidase, cytosolic IIIA	Homo sapiens	157-160
11095983-1	2000	Through efforts to investigate the CD33-like subgroup of sialic acid binding immunoglobulin-like lectins (Siglecs), which are believed to be located on chromosome 19q13.4, we have identified the precise genomic region containing the Siglec8 gene.	N-Acetylneuraminic Acid	57-68	CD33 molecule	Homo sapiens	35-39
11095983-1	2000	Through efforts to investigate the CD33-like subgroup of sialic acid binding immunoglobulin-like lectins (Siglecs), which are believed to be located on chromosome 19q13.4, we have identified the precise genomic region containing the Siglec8 gene.	N-Acetylneuraminic Acid	57-68	sialic acid binding Ig like lectin 8	Homo sapiens	233-240
11079462-8	2000	These results indicate that sialic acid residues of apo B- 100 play an important role in cellular uptake and degradation of LDL.	N-Acetylneuraminic Acid	28-39	apolipoprotein B	Homo sapiens	52-62
11114069-4	2000	ACE-ACE interaction was competitively inhibited by Neu5Ac- or Gal-terminated saccharides.	N-Acetylneuraminic Acid	51-57	angiotensin I converting enzyme	Homo sapiens	4-7
11425186-4	2000	The addition of sialic acid in alpha2,6-linkage to the galactose residue of lactosamine (type 2 chains) is catalyzed by beta-galactoside alpha2,6-sialyltransferase (ST6Gal.I).	N-Acetylneuraminic Acid	16-27	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	165-173
11054267-3	2000	GD3 expression was determined by high-performance thin-layer chromatography (HPTLC) and lipid-bound sialic acid and by static and flow cytometric analyses in peripheral blood lymphocytes from 22 AIDS patients, 20 anti-HIV Ab(+) asymptomatic subjects, and 25 healthy donors.	N-Acetylneuraminic Acid	100-111	GRDX	Homo sapiens	0-3
10947946-0	2000	The spectrum of SLC17A5-gene mutations resulting in free sialic acid-storage diseases indicates some genotype-phenotype correlation.	N-Acetylneuraminic Acid	57-68	solute carrier family 17 member 5	Homo sapiens	16-23
11096286-3	2000	We performed flow cytometry after immune staining using monoclonal antibodies to CD43 sialic acid-dependent (L60) and -independent (L10) epitopes.	N-Acetylneuraminic Acid	86-97	sialophorin	Homo sapiens	81-85
11093699-2	2000	Uronic acid-based mimetics in which an aliphatic ether (O-glycoside), a thioether (S-glycoside), or acetamide takes the place of the natural C-6 glycerol sidechain of the sialic acid were synthesized from the key intermediate, methyl 2,3,4-tri-O-acetyl-alpha-D-glucopyranosyluronate bromide.	N-Acetylneuraminic Acid	171-182	complement C6	Homo sapiens	141-144
11059835-1	2000	mST3GalV synthesizes ganglioside GM3, the precursor for simple and complex a- and b- series gangliosides, and the expression and regulation of mST3GalV (CMP-NeuAc: lactosylceramide alpha2,3-sialyltransferase) activity is central to the production of almost all gangliosides, a class of glycosphingolipids implicated in variety of cellular processes such as transmembrane signaling, synaptic transmission, specialized membrane domain formation and cell-cell interactions.	N-Acetylneuraminic Acid	157-162	matrix metallopeptidase 11	Mus musculus	0-4
11059835-1	2000	mST3GalV synthesizes ganglioside GM3, the precursor for simple and complex a- and b- series gangliosides, and the expression and regulation of mST3GalV (CMP-NeuAc: lactosylceramide alpha2,3-sialyltransferase) activity is central to the production of almost all gangliosides, a class of glycosphingolipids implicated in variety of cellular processes such as transmembrane signaling, synaptic transmission, specialized membrane domain formation and cell-cell interactions.	N-Acetylneuraminic Acid	157-162	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	0-8
10970796-2	2000	Sialic acid analysis and release, permethylation and analysis by GC-MS of the sialylated oligosaccharides isolated from the "insoluble" mucin complex revealed a relative decrease (4-7-fold) of N-glycolylneuraminic acid compared with N-acetylneuraminic acid just before parasite expulsion.	N-Acetylneuraminic Acid	0-11	solute carrier family 13 member 2	Rattus norvegicus	136-141
12687181-7	2000	It has been shown that two minor milk phospholipids, similarly to the previously described GM1, GM3 and GD3 gangliosides contain residue of sialic acid, but in conrast to the latter lipids, they can not be oxidized with sodium periodate; alkaline methanolysis of them results in formation of 4 and 5 products respectively, while hydrolysis of the gangliosides gives only one or two products.	N-Acetylneuraminic Acid	140-151	GRDX	Homo sapiens	104-107
10970796-2	2000	Sialic acid analysis and release, permethylation and analysis by GC-MS of the sialylated oligosaccharides isolated from the "insoluble" mucin complex revealed a relative decrease (4-7-fold) of N-glycolylneuraminic acid compared with N-acetylneuraminic acid just before parasite expulsion.	N-Acetylneuraminic Acid	233-256	solute carrier family 13 member 2	Rattus norvegicus	136-141
10982412-7	2000	The inhibitory effect of podocalyxin was reversed by treatment of the cells with Arthrobacter ureafaciens sialidase, indicating that sialic acid is required for inhibition of cell adhesion.	N-Acetylneuraminic Acid	133-144	podocalyxin like	Canis lupus familiaris	25-36
10936670-10	2000	Significant correlations were found between serum total sialic acid concentrations and such cardiovascular risk factors as plasma levels of apolipoprotein B, low density lipoprotein cholesterol, triglycerides and uric acid in the diabetic subjects.	N-Acetylneuraminic Acid	56-67	apolipoprotein B	Homo sapiens	140-156
10963781-2	2000	The main component of normal serum transferrin contains two biantennary glycans, each consisting of 2 mol of sialic acid (Tetrasialo transferrin).	N-Acetylneuraminic Acid	109-120	transferrin	Homo sapiens	35-46
11031813-1	2000	PURPOSE: We measured the concentration of sialic acid, the terminal component of mucin, in normal human tears.	N-Acetylneuraminic Acid	42-53	LOC100508689	Homo sapiens	81-86
11031813-8	2000	CONCLUSION: Our data indicates that concentration of sialic acid reflects that of glycoprotein and this method of measurement is applicable to the analysis of disorders with mucin deficiency.	N-Acetylneuraminic Acid	53-64	LOC100508689	Homo sapiens	174-179
10963781-2	2000	The main component of normal serum transferrin contains two biantennary glycans, each consisting of 2 mol of sialic acid (Tetrasialo transferrin).	N-Acetylneuraminic Acid	109-120	transferrin	Homo sapiens	133-144
10945239-3	2000	CAD+ subjects had a lower sialic acid ratio in total LDL and in its subfractions as compared with results in CAD- subjects.	N-Acetylneuraminic Acid	26-37	aconitate decarboxylase 1	Homo sapiens	0-4
10801862-0	2000	Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes.	N-Acetylneuraminic Acid	18-29	sialic acid binding Ig like lectin 9	Homo sapiens	0-8
10899930-5	2000	MAP1B in AEFs and membrane fractions from cultured dorsal root ganglion neurons (DRGNs) remains membrane-associated following high-salt washes and contains sialic acid.	N-Acetylneuraminic Acid	156-167	microtubule-associated protein 1B	Rattus norvegicus	0-5
11021662-7	2000	HPLC determined that 9.7x 10(7) NeuAc and 6.3x 10(7) NeuGc residues per cell were released from PAEC by neuraminidase, while 25.7x 10(7) NeuAc and an undetectable level of NeuGc were released from human aortic endothelial cells (HAEC).	N-Acetylneuraminic Acid	32-37	neuraminidase 1	Homo sapiens	104-117
10913821-3	2000	We report the occurrence of sialic acid in alpha 2,3- and alpha 2,6-linkage to galactose in bovine UPIII glycans as evidenced by the sensitivity of UPIII to both Vibrio cholera and Newcastle disease virus neuraminidase and by the colocalization of UPIII antigen and material detected by lectins of Sambucus nigra and Maackia amurensis on the luminal face of the bladder.	N-Acetylneuraminic Acid	28-39	uroplakin 3A	Bos taurus	99-104
10913821-3	2000	We report the occurrence of sialic acid in alpha 2,3- and alpha 2,6-linkage to galactose in bovine UPIII glycans as evidenced by the sensitivity of UPIII to both Vibrio cholera and Newcastle disease virus neuraminidase and by the colocalization of UPIII antigen and material detected by lectins of Sambucus nigra and Maackia amurensis on the luminal face of the bladder.	N-Acetylneuraminic Acid	28-39	uroplakin 3A	Bos taurus	148-153
10913821-3	2000	We report the occurrence of sialic acid in alpha 2,3- and alpha 2,6-linkage to galactose in bovine UPIII glycans as evidenced by the sensitivity of UPIII to both Vibrio cholera and Newcastle disease virus neuraminidase and by the colocalization of UPIII antigen and material detected by lectins of Sambucus nigra and Maackia amurensis on the luminal face of the bladder.	N-Acetylneuraminic Acid	28-39	uroplakin 3A	Bos taurus	148-153
10801862-5	2000	Binding assays showed that, similar to Siglec-7, Siglec-9 recognized sialic acid in either the alpha2,3- or alpha2, 6-glycosidic linkage to galactose.	N-Acetylneuraminic Acid	69-80	sialic acid binding Ig like lectin 9	Homo sapiens	49-57
10871579-4	2000	OBJECTIVE: The main purpose of this study was to determine the effects of chronic alcohol feeding of rats on the synthesis, sialylation, and sialic acid content of macrophage apo E and its ability to bind to the HDL(3) molecule in vitro.	N-Acetylneuraminic Acid	141-152	apolipoprotein E	Rattus norvegicus	175-180
10903842-1	2000	Using the positional cloning approach, we have identified siglec-9 (HGMW-approved symbol SIGLEC9) a novel member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF).	N-Acetylneuraminic Acid	120-131	sialic acid binding Ig like lectin 9	Homo sapiens	58-66
10903842-1	2000	Using the positional cloning approach, we have identified siglec-9 (HGMW-approved symbol SIGLEC9) a novel member of the sialic acid-binding Ig-like lectin (Siglec) family, which belongs to the immunoglobulin superfamily (IgSF).	N-Acetylneuraminic Acid	120-131	sialic acid binding Ig like lectin 9	Homo sapiens	89-96
10871579-8	2000	The sialic acid content of the intracellular and secreted forms of apo E was reduced by 41.8% (P &lt; 0.001) and 50.3% (P &lt; 0.001), respectively, with chronic alcohol treatment.	N-Acetylneuraminic Acid	4-15	apolipoprotein E	Rattus norvegicus	67-72
10871579-12	2000	CONCLUSION: In rats, an alcohol-mediated decrease in sialylation rate resulting in loss of sialic acid residues in apo E impairs the ability of apo E to bind to HDL and consequently in defective reverse cholesterol transport.	N-Acetylneuraminic Acid	91-102	apolipoprotein E	Rattus norvegicus	115-120
10871579-12	2000	CONCLUSION: In rats, an alcohol-mediated decrease in sialylation rate resulting in loss of sialic acid residues in apo E impairs the ability of apo E to bind to HDL and consequently in defective reverse cholesterol transport.	N-Acetylneuraminic Acid	91-102	apolipoprotein E	Rattus norvegicus	144-149
11004543-9	2000	In particular, the presence of sialic acid residues, within the oligosaccharide moiety of the GdA, might be responsible for the differences observed between the two proteins.	N-Acetylneuraminic Acid	31-42	progestagen associated endometrial protein	Homo sapiens	94-97
10853031-6	2000	Immunoblot analysis showed a higher expression of mucin associated carbohydrate antigens such as T, Tn, sialyl Tn, sialyl Lea, sialyl Lex and non-O-acetylated sialic acid concomitant with significant increases in the expression of goblet cell lineage marker, MUC2 apomucin and a panepithelial cell marker, carcinoembryonic antigen.	N-Acetylneuraminic Acid	159-170	LOC100508689	Homo sapiens	50-55
10939448-1	2000	Transferrin, an iron transport protein found in serum and cerebrospinal fluid, is known to be microheterogeneous with respect to its carbohydrate and sialic acid content.	N-Acetylneuraminic Acid	150-161	transferrin	Homo sapiens	0-11
10939448-2	2000	The forms of transferrin deficient in sialic acid and/or carbohydrate, termed carbohydrate-deficient transferrin (CDT), have been of clinical interest for almost two decades as a result of the initial finding that elevated CDT concentrations are associated with chronic, excessive alcohol abuse.	N-Acetylneuraminic Acid	38-49	transferrin	Homo sapiens	13-24
10939448-2	2000	The forms of transferrin deficient in sialic acid and/or carbohydrate, termed carbohydrate-deficient transferrin (CDT), have been of clinical interest for almost two decades as a result of the initial finding that elevated CDT concentrations are associated with chronic, excessive alcohol abuse.	N-Acetylneuraminic Acid	38-49	transferrin	Homo sapiens	101-112
10884293-4	2000	The LDL sialic acid ratio was inversely associated with respective lipid and apoB concentrations and positively with lipid-to-apoB ratios of LDL.	N-Acetylneuraminic Acid	8-19	apolipoprotein B	Homo sapiens	77-81
10884293-4	2000	The LDL sialic acid ratio was inversely associated with respective lipid and apoB concentrations and positively with lipid-to-apoB ratios of LDL.	N-Acetylneuraminic Acid	8-19	apolipoprotein B	Homo sapiens	126-130
10884293-5	2000	The transport rates (TRs) for total and dense LDL apoB were negatively associated with their sialic acid ratios.	N-Acetylneuraminic Acid	93-104	apolipoprotein B	Homo sapiens	50-54
10884293-8	2000	In conclusion, a low LDL sialic acid ratio was associated with CAD, high numbers of small LDL particles, and a high TR for LDL apoB, and in dense LDL also with high synthesis and low absorption of cholesterol.	N-Acetylneuraminic Acid	25-36	apolipoprotein B	Homo sapiens	127-131
10929045-5	2000	Neuraminidase-treated PNH RBCs became resistant to C" activation, suggesting that the sialic acid moieties on RBC membranes are involved in the interactions of RBC with C" components.	N-Acetylneuraminic Acid	86-97	neuraminidase 1	Homo sapiens	0-13
10872809-2	2000	It has been suggested that only ST6GalNAc I can synthesize carbohydrate structures of sialyl-Tn-antigen; i.e., NeuAc alpha2-6GalNAc-O-Thr/Ser [Kurosawa et al., J. Biol.	N-Acetylneuraminic Acid	111-116	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	Homo sapiens	32-43
11294501-0	2000	Glycosylated human interleukin-1alpha, neoglyco IL-1alpha, coupled with N-acetylneuraminic acid exhibits selective activities in vivo and altered tissue distribution.	N-Acetylneuraminic Acid	72-95	interleukin 1 alpha	Homo sapiens	19-37
11294501-0	2000	Glycosylated human interleukin-1alpha, neoglyco IL-1alpha, coupled with N-acetylneuraminic acid exhibits selective activities in vivo and altered tissue distribution.	N-Acetylneuraminic Acid	72-95	interleukin 1 alpha	Homo sapiens	48-57
11294501-1	2000	In order to study the effect of glycosylation on its biological activities and to develop IL-1 with less deleterious effects, N-acetylneuraminic acid (NeuAc) with C9 spacer was chemically coupled to human recombinant IL-1alpha.	N-Acetylneuraminic Acid	126-149	interleukin 1 alpha	Homo sapiens	90-94
11294501-1	2000	In order to study the effect of glycosylation on its biological activities and to develop IL-1 with less deleterious effects, N-acetylneuraminic acid (NeuAc) with C9 spacer was chemically coupled to human recombinant IL-1alpha.	N-Acetylneuraminic Acid	126-149	interleukin 1 alpha	Homo sapiens	217-226
11294501-1	2000	In order to study the effect of glycosylation on its biological activities and to develop IL-1 with less deleterious effects, N-acetylneuraminic acid (NeuAc) with C9 spacer was chemically coupled to human recombinant IL-1alpha.	N-Acetylneuraminic Acid	151-156	interleukin 1 alpha	Homo sapiens	90-94
11294501-1	2000	In order to study the effect of glycosylation on its biological activities and to develop IL-1 with less deleterious effects, N-acetylneuraminic acid (NeuAc) with C9 spacer was chemically coupled to human recombinant IL-1alpha.	N-Acetylneuraminic Acid	151-156	interleukin 1 alpha	Homo sapiens	217-226
11294501-2	2000	NeuAc-coupled IL-1alpha (NeuAc-IL-1alpha) exhibited reduced activities in vitro and receptor-binding affinities by about ten times compared to IL-1alpha.	N-Acetylneuraminic Acid	0-5	interleukin 1 alpha	Homo sapiens	14-23
11294501-2	2000	NeuAc-coupled IL-1alpha (NeuAc-IL-1alpha) exhibited reduced activities in vitro and receptor-binding affinities by about ten times compared to IL-1alpha.	N-Acetylneuraminic Acid	0-5	interleukin 1 alpha	Homo sapiens	31-40
11294501-2	2000	NeuAc-coupled IL-1alpha (NeuAc-IL-1alpha) exhibited reduced activities in vitro and receptor-binding affinities by about ten times compared to IL-1alpha.	N-Acetylneuraminic Acid	0-5	interleukin 1 alpha	Homo sapiens	31-40
11294501-2	2000	NeuAc-coupled IL-1alpha (NeuAc-IL-1alpha) exhibited reduced activities in vitro and receptor-binding affinities by about ten times compared to IL-1alpha.	N-Acetylneuraminic Acid	25-30	interleukin 1 alpha	Homo sapiens	14-23
11294501-2	2000	NeuAc-coupled IL-1alpha (NeuAc-IL-1alpha) exhibited reduced activities in vitro and receptor-binding affinities by about ten times compared to IL-1alpha.	N-Acetylneuraminic Acid	25-30	interleukin 1 alpha	Homo sapiens	31-40
11294501-2	2000	NeuAc-coupled IL-1alpha (NeuAc-IL-1alpha) exhibited reduced activities in vitro and receptor-binding affinities by about ten times compared to IL-1alpha.	N-Acetylneuraminic Acid	25-30	interleukin 1 alpha	Homo sapiens	31-40
11294501-4	2000	NeuAc-IL-1alpha exhibited a marked reduction in the activity to up-regulate serum IL-6, moderate reduction in the activities to up-regulate serum amyloid A and NOx.	N-Acetylneuraminic Acid	0-5	interleukin 1 alpha	Homo sapiens	6-15
11294501-4	2000	NeuAc-IL-1alpha exhibited a marked reduction in the activity to up-regulate serum IL-6, moderate reduction in the activities to up-regulate serum amyloid A and NOx.	N-Acetylneuraminic Acid	0-5	interleukin 6	Homo sapiens	82-86
11294501-6	2000	In addition, tissue level of NeuAc-IL-1alpha was high compared to IL-1alpha.	N-Acetylneuraminic Acid	29-34	interleukin 1 alpha	Homo sapiens	35-44
11294501-7	2000	These results indicate that coupling with NeuAc enabled us to develop neo-IL-1 with selective activities in vivo and enhanced tissue level.	N-Acetylneuraminic Acid	42-47	interleukin 1 alpha	Homo sapiens	74-78
10850459-1	2000	Polysialic acid (PSA) is a carbohydrate composed of a linear homopolymer of alpha-2-8-linked sialic acid residues and is mainly attached to the neural cell adhesion molecule (NCAM).	N-Acetylneuraminic Acid	4-15	neural cell adhesion molecule 1	Homo sapiens	144-173
10850459-1	2000	Polysialic acid (PSA) is a carbohydrate composed of a linear homopolymer of alpha-2-8-linked sialic acid residues and is mainly attached to the neural cell adhesion molecule (NCAM).	N-Acetylneuraminic Acid	4-15	neural cell adhesion molecule 1	Homo sapiens	175-179
10833268-7	2000	The sialic acid residues occur solely as Siaalpha2--&gt;3Gal groups of the recombinant L-PGDS; the sialic acid residues of other L-PGDS occur as both Siaalpha2--&gt;3Gal and Siaalpha2--&gt;6Gal groups.	N-Acetylneuraminic Acid	4-15	prostaglandin D2 synthase	Homo sapiens	87-93
10833268-7	2000	The sialic acid residues occur solely as Siaalpha2--&gt;3Gal groups of the recombinant L-PGDS; the sialic acid residues of other L-PGDS occur as both Siaalpha2--&gt;3Gal and Siaalpha2--&gt;6Gal groups.	N-Acetylneuraminic Acid	99-110	prostaglandin D2 synthase	Homo sapiens	87-93
10833268-7	2000	The sialic acid residues occur solely as Siaalpha2--&gt;3Gal groups of the recombinant L-PGDS; the sialic acid residues of other L-PGDS occur as both Siaalpha2--&gt;3Gal and Siaalpha2--&gt;6Gal groups.	N-Acetylneuraminic Acid	99-110	prostaglandin D2 synthase	Homo sapiens	129-135
10892586-1	2000	Transferrin sialoforms with fewer than three sialic acid residues (carbohydrate deficient transferrin; CDT) have been implicated as a marker of certain liver pathologies.	N-Acetylneuraminic Acid	45-56	transferrin	Homo sapiens	0-11
10812068-1	2000	The acetyl-CoA transporter gene (Acatn) encodes a hydrophobic, multitransmembrane protein that is involved in the process of O-acetylation of sialic acid residues on gangliosides.	N-Acetylneuraminic Acid	142-153	solute carrier family 33 (acetyl-CoA transporter), member 1	Mus musculus	4-31
10845701-7	2000	Both total carbohydrate content and relative amount of sialic acid were higher in BSSL from the first lactation month as compared to BSSL from milk collected later in lactation.	N-Acetylneuraminic Acid	55-66	carboxyl ester lipase	Homo sapiens	82-86
10812068-1	2000	The acetyl-CoA transporter gene (Acatn) encodes a hydrophobic, multitransmembrane protein that is involved in the process of O-acetylation of sialic acid residues on gangliosides.	N-Acetylneuraminic Acid	142-153	solute carrier family 33 (acetyl-CoA transporter), member 1	Mus musculus	33-38
10779780-4	2000	Three of these sites are involved in binding C3b and regulating complement activation; others bind to sialic acid and/or heparin and are responsible for host recognition.	N-Acetylneuraminic Acid	102-113	endogenous retrovirus group K member 3	Homo sapiens	45-48
10745191-3	2000	We report here the partial cloning of the CMP-sialic acid:Galbeta1,3GalNAcalpha2, 3-sialyltransferase (ST3Gal I) gene from Chinese hamster ovary (CHO) cells and the simultaneous inhibition of expression of CHO cell ST3Gal I gene and overexpression of the human UDP-GlcNAc:Galbeta1, 3GalNAc-R beta1,6-N-acetylglucosaminyltransferase (C2GnT) gene.	N-Acetylneuraminic Acid	46-57	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	333-338
10788349-2	2000	Peroxidase-labeled concanavalin A (ConA) and wheat germ agglutinin (WGA) were used, as they specifically bind to saccharide residues most frequently encountered in biofilms matrices: D-glucose or D-mannose for ConA and N-acetyl-D-glucosamine or N-acetylneuraminic acid for WGA.	N-Acetylneuraminic Acid	245-268	peroxidase-like	Triticum aestivum	0-10
10939515-6	2000	Our results suggest the presence of N-acetylglucosamine (GlcNAc), Man, Glc, N-acetylneuraminic acid (Neu5Ac)(alpha2-6)- and Neu5Ac(alpha2-3)-linked, N-acetylgalactosamine (GalNAc) and Gal(beta1-3)GalNAc in the oligosaccharides of the goblet cells.	N-Acetylneuraminic Acid	76-99	immunoglobulin binding protein 1	Homo sapiens	109-117
10939515-6	2000	Our results suggest the presence of N-acetylglucosamine (GlcNAc), Man, Glc, N-acetylneuraminic acid (Neu5Ac)(alpha2-6)- and Neu5Ac(alpha2-3)-linked, N-acetylgalactosamine (GalNAc) and Gal(beta1-3)GalNAc in the oligosaccharides of the goblet cells.	N-Acetylneuraminic Acid	101-107	immunoglobulin binding protein 1	Homo sapiens	109-117
10779781-6	2000	Deglycosylation experiments with neuraminidase and Endo-F combined with two-dimensional PAGE of single bands of the intracellular vs extracellular IL-12 heterodimer revealed that the alpha-chain was extensively modified with sialic acid adducts to N-linked oligosaccharides before secretion.	N-Acetylneuraminic Acid	225-236	Fc gamma receptor and transporter	Homo sapiens	183-194
10777713-5	2000	The results obtained clearly showed a decrease of GalNAc, Gal, and sialic acid in IgAN compared with non-IgAN and normal controls, and those strongly suggested the possibility that the decreased galactosylation and sialylation of the IgA1 hinge result in its glomerular deposition in IgAN.	N-Acetylneuraminic Acid	67-78	IGAN1	Homo sapiens	82-86
10823262-0	2000	Decreased sialic acid content of plasma von Willebrand factor in precapillary pulmonary hypertension.	N-Acetylneuraminic Acid	10-21	von Willebrand factor	Homo sapiens	40-61
10823262-3	2000	Since asialo vWF has been shown to promote platelet activation and aggregation, we decided to investigate possible changes in the sialic acid content of plasma vWF in patients with precapillary pulmonary hypertension.	N-Acetylneuraminic Acid	130-141	von Willebrand factor	Homo sapiens	160-163
10823262-4	2000	vWF-associated sialic acid was measured indirectly as a wheat germ agglutinin-reactive substance (WGA-RS, Western blotting), and directly, as a thiobarbituric acid-reactive substance (TBA-RS, spectrophotometric reading).	N-Acetylneuraminic Acid	15-26	von Willebrand factor	Homo sapiens	0-3
10823262-6	2000	However, patient vWF subunit contained 19% (WGA-RS) to 24% (TBA-RS) less sialic acid than the normal protein (p &lt;0.05 for both determinations).	N-Acetylneuraminic Acid	73-84	von Willebrand factor	Homo sapiens	17-20
10823262-7	2000	In five patients, vWF-associated sialic acid was below 50% normal.	N-Acetylneuraminic Acid	33-44	von Willebrand factor	Homo sapiens	18-21
10722601-4	2000	Transposon-derived type III strain COH1-13, which lacks capsular polysaccharide, and strain COH1-11 with capsular polysaccharide lacking terminal sialic acid demonstrated increased neutrophil binding, suggesting that capsular polysaccharide masks an underlying binding site.	N-Acetylneuraminic Acid	146-157	vacuolar protein sorting 13 homolog B	Homo sapiens	92-96
10764831-0	2000	Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.	N-Acetylneuraminic Acid	12-23	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
10715574-5	2000	In the vertebrate nervous system, NCAM is the dominant carrier of polysialic acid (PSA), an unusual carbohydrate consisting of long homopolymers of sialic acid.	N-Acetylneuraminic Acid	70-81	neural cell adhesion molecule 1	Rattus norvegicus	34-38
10722702-8	2000	Third, siglec-5 binds alpha2-8-linked sialic acid, making it the siglec least specific for linkage recognition.	N-Acetylneuraminic Acid	38-49	sialic acid-binding Ig-like lectin 5	Bos taurus	7-15
10704380-2	2000	Most of these sialic acid residues are incorporated into mucin-like glycoproteins.	N-Acetylneuraminic Acid	14-25	LOC100508689	Homo sapiens	57-62
10827345-4	2000	Transferrin glycosylation was assessed by measuring the sialic acid content of transferrin.	N-Acetylneuraminic Acid	56-67	transferrin	Rattus norvegicus	0-11
10827345-4	2000	Transferrin glycosylation was assessed by measuring the sialic acid content of transferrin.	N-Acetylneuraminic Acid	56-67	transferrin	Rattus norvegicus	79-90
10763998-14	2000	Neuraminidase was used to digest sialic acid side chains from pure transferrin in solution, and the reaction product was used as a reference standard for comparison to assay of unknown fluids.	N-Acetylneuraminic Acid	33-44	neuraminidase 1	Homo sapiens	0-13
10763998-14	2000	Neuraminidase was used to digest sialic acid side chains from pure transferrin in solution, and the reaction product was used as a reference standard for comparison to assay of unknown fluids.	N-Acetylneuraminic Acid	33-44	transferrin	Homo sapiens	67-78
10722703-5	2000	Human siglec-1 (sialoadhesin) strongly prefers Neu5Ac over Neu5Gc.	N-Acetylneuraminic Acid	47-53	sialic acid binding Ig like lectin 1	Homo sapiens	6-14
10722703-5	2000	Human siglec-1 (sialoadhesin) strongly prefers Neu5Ac over Neu5Gc.	N-Acetylneuraminic Acid	47-53	sialic acid binding Ig like lectin 1	Homo sapiens	16-28
10722703-9	2000	A known evolutionary difference is the strong preference of mouse siglec-2 (CD22) for Neu5Gc, contrasting with human siglec-2, which binds Neu5Ac equally well.	N-Acetylneuraminic Acid	139-145	CD22 molecule	Homo sapiens	117-125
11249523-7	2000	The sialic acid analogue, GS4071, has been shown to be a potent inhibitor of neuraminidase activity and is shown to be effective in controlling influenza, and its prodrug form--GS4104 (oseltamivir) can be given orally.	N-Acetylneuraminic Acid	4-15	neuraminidase 1	Homo sapiens	77-90
10702226-1	2000	A novel member of the mouse CMP-NeuAc:beta-N-acetylgalactosaminide alpha2,6-sialyltransferase (ST6GalNAc) subfamily, designated ST6GalNAc VI, was identified by BLAST analysis of expressed sequence tags.	N-Acetylneuraminic Acid	32-37	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	Mus musculus	95-104
10702226-1	2000	A novel member of the mouse CMP-NeuAc:beta-N-acetylgalactosaminide alpha2,6-sialyltransferase (ST6GalNAc) subfamily, designated ST6GalNAc VI, was identified by BLAST analysis of expressed sequence tags.	N-Acetylneuraminic Acid	32-37	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	Mus musculus	128-140
10732983-0	2000	Synthesis and evaluation of C-9 modified N-acetylneuraminic acid derivatives as substrates for N-acetylneuraminic acid aldolase.	N-Acetylneuraminic Acid	41-64	complement C9	Homo sapiens	28-31
10732983-0	2000	Synthesis and evaluation of C-9 modified N-acetylneuraminic acid derivatives as substrates for N-acetylneuraminic acid aldolase.	N-Acetylneuraminic Acid	41-64	N-acetylneuraminate pyruvate lyase	Homo sapiens	95-127
10732983-1	2000	Several C-9 modified N-acetylneuraminic acid derivatives have been synthesised and evaluated as substrates of N-acetylneuraminic acid aldolase.	N-Acetylneuraminic Acid	21-44	complement C9	Homo sapiens	8-11
10732983-1	2000	Several C-9 modified N-acetylneuraminic acid derivatives have been synthesised and evaluated as substrates of N-acetylneuraminic acid aldolase.	N-Acetylneuraminic Acid	21-44	N-acetylneuraminate pyruvate lyase	Homo sapiens	110-142
10732983-2	2000	Simple C-9 acyl or ether modified derivatives of N-acetylneuraminic acid were found to be accepted as substrates by the enzyme, albeit being transformed more slowly than Neu5Ac itself.	N-Acetylneuraminic Acid	49-72	complement C9	Homo sapiens	7-10
10732983-2	2000	Simple C-9 acyl or ether modified derivatives of N-acetylneuraminic acid were found to be accepted as substrates by the enzyme, albeit being transformed more slowly than Neu5Ac itself.	N-Acetylneuraminic Acid	170-176	complement C9	Homo sapiens	7-10
10712595-8	2000	Salmon antithrombin appears to have three complex oligosaccharide side chains containing sialic acid terminally linked alpha(2-3) to galactose, while trace amounts of Galbeta(1-4)GlcNAc suggest microheterogeneity due to partial loss of sialic acid.	N-Acetylneuraminic Acid	89-100	serpin family C member 1	Homo sapiens	7-19
10712595-8	2000	Salmon antithrombin appears to have three complex oligosaccharide side chains containing sialic acid terminally linked alpha(2-3) to galactose, while trace amounts of Galbeta(1-4)GlcNAc suggest microheterogeneity due to partial loss of sialic acid.	N-Acetylneuraminic Acid	236-247	serpin family C member 1	Homo sapiens	7-19
10704530-0	2000	A novel viral alpha2,3-sialyltransferase (v-ST3Gal I): transfer of sialic acid to fucosylated acceptors.	N-Acetylneuraminic Acid	67-78	m138L	Myxoma virus	14-40
10722868-3	2000	The m&amp;phi;-restricted sheep erythrocyte receptor sialoadhesin (Sn) is a member of the immunglobulin superfamily and binds specifically to sialic acid-containing structures such as selectins and was originally identified as the sheep erythrocyte receptor (SER) responsible for sialic acid-dependent binding of native sheep erythrocytes (SE) to resident murine bone marrow macrophages in rosetting assays.	N-Acetylneuraminic Acid	142-153	sialic acid binding Ig like lectin 1	Rattus norvegicus	53-65
10755614-2	2000	CD8+ T cells undergo an elimination of sialic acid on core 1 O-glycans and an induction of core 2 O-glycans until either apoptotic death or differentiation into memory cells.	N-Acetylneuraminic Acid	39-50	CD8a molecule	Homo sapiens	0-3
10736100-6	2000	N-linked, but not O-linked, oligosaccharides of patients" IgA1 were oversialylated, and this seemed to be linked to an excess of SA on the same number of polysaccharides as normal IgA1.	N-Acetylneuraminic Acid	129-131	immunoglobulin heavy constant alpha 1	Homo sapiens	58-62
10736100-4	2000	We extend this finding by showing that monomeric IgA1 contains more sialic acid (SA) in patients than in controls, as determined by enzyme-linked immunosorbent assay (ELISA) and Western blot with Sambucus nigra agglutinin (SNA), a lectin specific for SA.	N-Acetylneuraminic Acid	68-79	immunoglobulin heavy constant alpha 1	Homo sapiens	49-53
10736100-4	2000	We extend this finding by showing that monomeric IgA1 contains more sialic acid (SA) in patients than in controls, as determined by enzyme-linked immunosorbent assay (ELISA) and Western blot with Sambucus nigra agglutinin (SNA), a lectin specific for SA.	N-Acetylneuraminic Acid	81-83	immunoglobulin heavy constant alpha 1	Homo sapiens	49-53
10736100-4	2000	We extend this finding by showing that monomeric IgA1 contains more sialic acid (SA) in patients than in controls, as determined by enzyme-linked immunosorbent assay (ELISA) and Western blot with Sambucus nigra agglutinin (SNA), a lectin specific for SA.	N-Acetylneuraminic Acid	170-172	immunoglobulin heavy constant alpha 1	Homo sapiens	49-53
10722868-3	2000	The m&amp;phi;-restricted sheep erythrocyte receptor sialoadhesin (Sn) is a member of the immunglobulin superfamily and binds specifically to sialic acid-containing structures such as selectins and was originally identified as the sheep erythrocyte receptor (SER) responsible for sialic acid-dependent binding of native sheep erythrocytes (SE) to resident murine bone marrow macrophages in rosetting assays.	N-Acetylneuraminic Acid	280-291	sialic acid binding Ig like lectin 1	Rattus norvegicus	53-65
10715554-13	2000	Thus truncated hFSH-R variants do not reach the medial or trans Golgi where high mannose oligosaccharides are trimmed and sialic acid is added.	N-Acetylneuraminic Acid	122-133	follicle stimulating hormone receptor	Homo sapiens	15-21
10744316-2	2000	It indicates a group of isoforms of human transferrin (Tf), the main iron transport serum protein, deficient in sialic acid residues (asialo-, monosialo- and disialo-Tf) in comparison to the main isotransferrin which contains four sialic acid groups (tetrasialo-Tf).	N-Acetylneuraminic Acid	112-123	transferrin	Homo sapiens	42-53
10744316-2	2000	It indicates a group of isoforms of human transferrin (Tf), the main iron transport serum protein, deficient in sialic acid residues (asialo-, monosialo- and disialo-Tf) in comparison to the main isotransferrin which contains four sialic acid groups (tetrasialo-Tf).	N-Acetylneuraminic Acid	112-123	transferrin	Homo sapiens	55-57
10744316-2	2000	It indicates a group of isoforms of human transferrin (Tf), the main iron transport serum protein, deficient in sialic acid residues (asialo-, monosialo- and disialo-Tf) in comparison to the main isotransferrin which contains four sialic acid groups (tetrasialo-Tf).	N-Acetylneuraminic Acid	231-242	transferrin	Homo sapiens	42-53
10744316-2	2000	It indicates a group of isoforms of human transferrin (Tf), the main iron transport serum protein, deficient in sialic acid residues (asialo-, monosialo- and disialo-Tf) in comparison to the main isotransferrin which contains four sialic acid groups (tetrasialo-Tf).	N-Acetylneuraminic Acid	231-242	transferrin	Homo sapiens	55-57
10741468-6	2000	We show here that bath-applied sialic acid has an effect directly opposite that of agrin or neuraminidase.	N-Acetylneuraminic Acid	31-42	agrin	Homo sapiens	83-88
10671508-8	2000	Additional experiments demonstrated that low molecular weight apoE present on the cell surface was modified to higher molecular weight apoE by the addition of sialic acid residues prior to secretion and that this conversion was inhibited by brefeldin A.	N-Acetylneuraminic Acid	159-170	apolipoprotein E	Homo sapiens	62-66
10671508-8	2000	Additional experiments demonstrated that low molecular weight apoE present on the cell surface was modified to higher molecular weight apoE by the addition of sialic acid residues prior to secretion and that this conversion was inhibited by brefeldin A.	N-Acetylneuraminic Acid	159-170	apolipoprotein E	Homo sapiens	135-139
10741468-0	2000	Sialic acid inhibits agrin signaling in C2 myotubes.	N-Acetylneuraminic Acid	0-11	agrin	Homo sapiens	21-26
10741468-6	2000	We show here that bath-applied sialic acid has an effect directly opposite that of agrin or neuraminidase.	N-Acetylneuraminic Acid	31-42	neuraminidase 1	Homo sapiens	92-105
10741468-4	2000	Both the phosphorylation events and AChR clustering can also be induced by neuraminidase, an enzyme that cleaves sialic acid from glycoconjugates, suggesting that neuraminidase is able to activate the agrin signaling pathway.	N-Acetylneuraminic Acid	113-124	neuraminidase 1	Homo sapiens	75-88
10741468-7	2000	Sialic acid not only decreases AChR clustering but also diminishes the tyrosine phosphorylation of MuSK and the AChR beta-subunit signal-transduction events normally driven by agrin.	N-Acetylneuraminic Acid	0-11	cholinergic receptor nicotinic beta 1 subunit	Homo sapiens	112-121
10741468-4	2000	Both the phosphorylation events and AChR clustering can also be induced by neuraminidase, an enzyme that cleaves sialic acid from glycoconjugates, suggesting that neuraminidase is able to activate the agrin signaling pathway.	N-Acetylneuraminic Acid	113-124	neuraminidase 1	Homo sapiens	163-176
10741468-4	2000	Both the phosphorylation events and AChR clustering can also be induced by neuraminidase, an enzyme that cleaves sialic acid from glycoconjugates, suggesting that neuraminidase is able to activate the agrin signaling pathway.	N-Acetylneuraminic Acid	113-124	agrin	Homo sapiens	201-206
10741468-7	2000	Sialic acid not only decreases AChR clustering but also diminishes the tyrosine phosphorylation of MuSK and the AChR beta-subunit signal-transduction events normally driven by agrin.	N-Acetylneuraminic Acid	0-11	agrin	Homo sapiens	176-181
10741468-9	2000	We propose a regulatory role for sialic acid in the signal transduction events of neuromuscular synapse formation, in which agrin or neuraminidase can overcome this sialic acid repression, resulting in the clustering of AChRs and other postsynaptic molecules.	N-Acetylneuraminic Acid	33-44	agrin	Homo sapiens	124-129
10741468-9	2000	We propose a regulatory role for sialic acid in the signal transduction events of neuromuscular synapse formation, in which agrin or neuraminidase can overcome this sialic acid repression, resulting in the clustering of AChRs and other postsynaptic molecules.	N-Acetylneuraminic Acid	33-44	neuraminidase 1	Homo sapiens	133-146
10741468-9	2000	We propose a regulatory role for sialic acid in the signal transduction events of neuromuscular synapse formation, in which agrin or neuraminidase can overcome this sialic acid repression, resulting in the clustering of AChRs and other postsynaptic molecules.	N-Acetylneuraminic Acid	165-176	agrin	Homo sapiens	124-129
10741468-9	2000	We propose a regulatory role for sialic acid in the signal transduction events of neuromuscular synapse formation, in which agrin or neuraminidase can overcome this sialic acid repression, resulting in the clustering of AChRs and other postsynaptic molecules.	N-Acetylneuraminic Acid	165-176	neuraminidase 1	Homo sapiens	133-146
10625634-1	2000	Osteopontin (OPN) is a sialic acid-rich, adhesive, extracellular matrix (ECM) protein with Arg-Gly-Asp cell-binding sequence that interacts with several integrins, including alpha(v)beta(3).	N-Acetylneuraminic Acid	23-34	secreted phosphoprotein 1	Mus musculus	0-11
10625619-2	2000	We describe the characterization of siglec-8, a novel sialic acid-binding immunoglobulin-like lectin that is expressed specifically by eosinophils.	N-Acetylneuraminic Acid	54-65	sialic acid binding Ig like lectin 8	Homo sapiens	36-44
10625634-1	2000	Osteopontin (OPN) is a sialic acid-rich, adhesive, extracellular matrix (ECM) protein with Arg-Gly-Asp cell-binding sequence that interacts with several integrins, including alpha(v)beta(3).	N-Acetylneuraminic Acid	23-34	secreted phosphoprotein 1	Mus musculus	13-16
10625619-6	2000	When siglec-8 was expressed on COS cells or as a recombinant protein fused to the Fc region of human IgG(1), it was able to mediate sialic acid-dependent binding to human erythrocytes and to soluble sialoglycoconjugates.	N-Acetylneuraminic Acid	132-143	sialic acid binding Ig like lectin 8	Homo sapiens	5-13
10714394-6	2000	Indeed, after removal of sialic acid from their cell surface by neuraminidase, LB cells acquired the ability to bind HA.	N-Acetylneuraminic Acid	25-36	neuraminidase 1	Homo sapiens	64-77
11310976-3	2000	The results showed a large deficit of N-acetylgalactosamine, galactose, and sialic acid residues in glycophorin A from patients with CDA type I and type II amounting to about 45% and 55%, respectively.	N-Acetylneuraminic Acid	76-87	glycophorin A (MNS blood group)	Homo sapiens	100-113
10651761-10	2000	Leptin was strongly correlated with BMI (r = 0.61, P &lt; 0.001), but also with sialic acid (r = 0.40, P = 0.01) and IL-6 (r = 0.38, P = 0.04).	N-Acetylneuraminic Acid	80-91	leptin	Homo sapiens	0-6
11051459-3	2000	The goal of this study was to determine the contribution of glycosylation, specifically the presence of sialic acid, to beta1-integrin adhesion in a neutrophil model.	N-Acetylneuraminic Acid	104-115	integrin subunit beta 1	Homo sapiens	120-134
10590089-5	2000	First, Ad37 attachment to both CAR-expressing CHO cells and MHC-I alpha2-expressing Daudi cells was sensitive to neuraminidase treatment, which eliminates sialic acid on the cell surface.	N-Acetylneuraminic Acid	155-166	neuraminidase 1	Homo sapiens	113-126
11185721-7	2000	Treatment with neuraminidase (0.1 unit/ml) of untreated or prefixed monolayers resulted in a significant decrease in WGA binding to fibrils (and increase in PNA binding), indicating that terminal sialic acid residues are mainly involved in the network-WGA interaction.	N-Acetylneuraminic Acid	196-207	neuraminidase 1	Homo sapiens	15-28
10690709-3	2000	In human milk, the total lipid-bound sialic acid level was two times higher than those in cow"s milk and infant formulas.	N-Acetylneuraminic Acid	37-48	Weaning weight-maternal milk	Bos taurus	9-13
10570219-0	2000	Conversion of cellular sialic acid expression from N-acetyl- to N-glycolylneuraminic acid using a synthetic precursor, N-glycolylmannosamine pentaacetate: inhibition of myelin-associated glycoprotein binding to neural cells.	N-Acetylneuraminic Acid	23-34	myelin associated glycoprotein	Homo sapiens	169-199
10570219-2	2000	Binding of the sialic acid-dependent lectin, myelin-associated glycoprotein (MAG), to nerve cells is implicated in the inhibition of nerve regeneration after injury.	N-Acetylneuraminic Acid	15-26	myelin associated glycoprotein	Homo sapiens	45-75
10570219-2	2000	Binding of the sialic acid-dependent lectin, myelin-associated glycoprotein (MAG), to nerve cells is implicated in the inhibition of nerve regeneration after injury.	N-Acetylneuraminic Acid	15-26	myelin associated glycoprotein	Homo sapiens	77-80
10570219-4	2000	Previously, we reported that certain sialoglycoconjugates bearing N-acetylneuraminic acid (NeuAc) but not N-glycolylneuraminic acid (NeuGc) support MAG binding (Collins et al., 1997a).	N-Acetylneuraminic Acid	66-89	myelin associated glycoprotein	Homo sapiens	148-151
10570219-4	2000	Previously, we reported that certain sialoglycoconjugates bearing N-acetylneuraminic acid (NeuAc) but not N-glycolylneuraminic acid (NeuGc) support MAG binding (Collins et al., 1997a).	N-Acetylneuraminic Acid	91-96	myelin associated glycoprotein	Homo sapiens	148-151
10608819-1	1999	Extended glycoconjugate binding specificities of three sialic acid-dependent immunoglobulin-like family member lectins (siglecs), myelin-associated glycoprotein (MAG), Schwann cell myelin protein (SMP), and sialoadhesin, were compared by measuring siglec-mediated cell adhesion to immobilized gangliosides.	N-Acetylneuraminic Acid	55-66	sialic acid binding Ig like lectin 1	Homo sapiens	207-219
11146890-5	2000	Due to the elongated, twig-resembling shapes and numerous negatively charged rests of sialic acid CD43 can act in an anti-adhesive fashion e.g., disturbing ICAM-1 (CD54)--LFA-1 (CD11A/CD18) interaction.	N-Acetylneuraminic Acid	86-97	sialophorin	Homo sapiens	98-102
11146890-5	2000	Due to the elongated, twig-resembling shapes and numerous negatively charged rests of sialic acid CD43 can act in an anti-adhesive fashion e.g., disturbing ICAM-1 (CD54)--LFA-1 (CD11A/CD18) interaction.	N-Acetylneuraminic Acid	86-97	intercellular adhesion molecule 1	Homo sapiens	156-162
11146890-5	2000	Due to the elongated, twig-resembling shapes and numerous negatively charged rests of sialic acid CD43 can act in an anti-adhesive fashion e.g., disturbing ICAM-1 (CD54)--LFA-1 (CD11A/CD18) interaction.	N-Acetylneuraminic Acid	86-97	intercellular adhesion molecule 1	Homo sapiens	164-168
11146890-5	2000	Due to the elongated, twig-resembling shapes and numerous negatively charged rests of sialic acid CD43 can act in an anti-adhesive fashion e.g., disturbing ICAM-1 (CD54)--LFA-1 (CD11A/CD18) interaction.	N-Acetylneuraminic Acid	86-97	integrin subunit alpha L	Homo sapiens	171-176
11146890-5	2000	Due to the elongated, twig-resembling shapes and numerous negatively charged rests of sialic acid CD43 can act in an anti-adhesive fashion e.g., disturbing ICAM-1 (CD54)--LFA-1 (CD11A/CD18) interaction.	N-Acetylneuraminic Acid	86-97	integrin subunit alpha L	Homo sapiens	178-183
11146890-5	2000	Due to the elongated, twig-resembling shapes and numerous negatively charged rests of sialic acid CD43 can act in an anti-adhesive fashion e.g., disturbing ICAM-1 (CD54)--LFA-1 (CD11A/CD18) interaction.	N-Acetylneuraminic Acid	86-97	integrin subunit beta 2	Homo sapiens	184-188
10581036-12	1999	Our observations suggest that mutations in SLC17A5 are the primary cause of lysosomal sialic acid storage diseases.	N-Acetylneuraminic Acid	86-97	solute carrier family 17 member 5	Homo sapiens	43-50
10603317-1	1999	Sialic acid is the receptor determinant for the human parainfluenza virus type 3 (HPF3) hemagglutinin-neuraminidase (HN) glycoprotein, the molecule responsible for binding of the virus to cell surfaces.	N-Acetylneuraminic Acid	0-11	zinc finger protein 17	Homo sapiens	82-86
10603317-1	1999	Sialic acid is the receptor determinant for the human parainfluenza virus type 3 (HPF3) hemagglutinin-neuraminidase (HN) glycoprotein, the molecule responsible for binding of the virus to cell surfaces.	N-Acetylneuraminic Acid	0-11	hemagglutinin-neuraminidase	Human respirovirus 3	88-115
10603317-1	1999	Sialic acid is the receptor determinant for the human parainfluenza virus type 3 (HPF3) hemagglutinin-neuraminidase (HN) glycoprotein, the molecule responsible for binding of the virus to cell surfaces.	N-Acetylneuraminic Acid	0-11	hemagglutinin-neuraminidase	Human respirovirus 3	117-119
10603317-16	1999	Our results indicate that specific sialic acid analogs that mimic the cellular receptor determinant of HPF3 can block virus cell interaction and that an unsaturated n-acetyl-neuraminic acid derivative with affinity to the HN site responsible for neuraminidase activity also interferes with HN-receptor binding.	N-Acetylneuraminic Acid	35-46	zinc finger protein 17	Homo sapiens	103-107
10561455-4	1999	in situ hybridization of primary breast tissue showed that a sialyltransferase (ST3Gal I), responsible for adding sialic acid to core 1 thereby terminating chain extension, is elevated in primary breast carcinomas when compared to normal or benign tissue.	N-Acetylneuraminic Acid	114-125	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	61-88
10607305-3	1999	To test this hypothesis, we developed a method (based on sialyl transferases eluted from a hepatoma cell line) to increase the amount of sialic acid (SA) on IgA, and used a battery of IgA1- and IgA2-specific glycosidases to reduce this amount.	N-Acetylneuraminic Acid	137-148	CD79a molecule	Homo sapiens	157-160
10607305-3	1999	To test this hypothesis, we developed a method (based on sialyl transferases eluted from a hepatoma cell line) to increase the amount of sialic acid (SA) on IgA, and used a battery of IgA1- and IgA2-specific glycosidases to reduce this amount.	N-Acetylneuraminic Acid	150-152	CD79a molecule	Homo sapiens	157-160
10607305-6	1999	Given that IgA are oversialylated in pSS, defective clearance of IgA may indeed be ascribed to an excess of SA in IgA1 and IgA2.	N-Acetylneuraminic Acid	108-110	CD79a molecule	Homo sapiens	11-14
10607305-6	1999	Given that IgA are oversialylated in pSS, defective clearance of IgA may indeed be ascribed to an excess of SA in IgA1 and IgA2.	N-Acetylneuraminic Acid	108-110	CD79a molecule	Homo sapiens	65-68
10580514-1	1999	Chronic alcohol exposure leads to the appearance of carbohydrate-deficient transferrin (CDT), a N-glycosylated protein and sialic acid-deficient apolipoprotein E (apoE), an O-glycosylated protein.	N-Acetylneuraminic Acid	123-134	apolipoprotein E	Homo sapiens	145-161
10607305-6	1999	Given that IgA are oversialylated in pSS, defective clearance of IgA may indeed be ascribed to an excess of SA in IgA1 and IgA2.	N-Acetylneuraminic Acid	108-110	immunoglobulin heavy constant alpha 1	Homo sapiens	114-118
10567377-5	1999	When siglec-7 was expressed on COS or Chinese hamster ovary cells, it was able to mediate high levels of sialic acid-dependent binding to human erythrocytes and soluble sialoglycoconjugates, suggesting that it may be involved in cell-cell interactions.	N-Acetylneuraminic Acid	105-116	sialic acid binding Ig like lectin 7	Homo sapiens	5-13
10570199-2	1999	Whereas Plasmodium vivax and Plasmodium knowlesi use the Duffy blood group antigen, Plasmodium falciparum uses sialic acid residues of glycophorin A as receptors to invade human erythrocytes.	N-Acetylneuraminic Acid	111-122	glycophorin A (MNS blood group)	Homo sapiens	135-148
10577497-4	1999	Sn is a prototypical member of the siglec family of sialic acid binding proteins, which includes CD22, myelin-associated glycoprotein, CD33, and siglec-5.	N-Acetylneuraminic Acid	52-63	sialic acid binding Ig like lectin 1	Homo sapiens	0-2
10877458-3	1999	On the basis of the three-dimensional structure of neuraminidase and the structure of the enzyme-product complex, novel analogues of the product (sialic acid, Neu5Ac) were designed and were shown to be potent inhibitors of neuraminidase in vitro and in vivo.	N-Acetylneuraminic Acid	146-157	neuraminidase 1	Homo sapiens	51-64
10877458-3	1999	On the basis of the three-dimensional structure of neuraminidase and the structure of the enzyme-product complex, novel analogues of the product (sialic acid, Neu5Ac) were designed and were shown to be potent inhibitors of neuraminidase in vitro and in vivo.	N-Acetylneuraminic Acid	146-157	neuraminidase 1	Homo sapiens	223-236
10877458-3	1999	On the basis of the three-dimensional structure of neuraminidase and the structure of the enzyme-product complex, novel analogues of the product (sialic acid, Neu5Ac) were designed and were shown to be potent inhibitors of neuraminidase in vitro and in vivo.	N-Acetylneuraminic Acid	159-165	neuraminidase 1	Homo sapiens	51-64
10877458-3	1999	On the basis of the three-dimensional structure of neuraminidase and the structure of the enzyme-product complex, novel analogues of the product (sialic acid, Neu5Ac) were designed and were shown to be potent inhibitors of neuraminidase in vitro and in vivo.	N-Acetylneuraminic Acid	159-165	neuraminidase 1	Homo sapiens	223-236
10556798-6	1999	The precise function of CD33 is unknown although it is a lectin that binds sialic acid residues in N- and O-glycans on cell surfaces.	N-Acetylneuraminic Acid	75-86	CD33 molecule	Homo sapiens	24-28
10536038-1	1999	We recently reported that the sialic acid-specific binding sites of CD22 molecules on B cells are masked by endogenous ligands, and can be unmasked by sialidase treatment or cellular activation.	N-Acetylneuraminic Acid	30-41	CD22 molecule	Homo sapiens	68-72
10577497-6	1999	The sialic acid binding region of siglecs is localized within the membrane-distal, amino-terminal domain and in the case of Sn, it has been characterized in atomic detail by X-ray crystallography, nuclear magnetic resonance, and site-directed mutagenesis.	N-Acetylneuraminic Acid	4-15	sialic acid binding Ig like lectin 1	Homo sapiens	124-126
10515876-11	1999	Sialidase digestion and removal of terminal sialic acid residues from HUVEC or THP-1 cells but not from platelets abolished the platelet mediated augmentation of THP-1 cell adhesion.	N-Acetylneuraminic Acid	44-55	GLI family zinc finger 2	Homo sapiens	79-84
10521438-1	1999	A novel member of the mouse CMP-NeuAc: beta-N-acetylgalactosaminide alpha2,6-sialyltransferase (ST6GalNAc) subfamily, designated ST6GalNAc V, was identified by BLAST analysis of expressed sequence tags.	N-Acetylneuraminic Acid	32-37	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	Mus musculus	96-105
10521438-1	1999	A novel member of the mouse CMP-NeuAc: beta-N-acetylgalactosaminide alpha2,6-sialyltransferase (ST6GalNAc) subfamily, designated ST6GalNAc V, was identified by BLAST analysis of expressed sequence tags.	N-Acetylneuraminic Acid	32-37	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	Mus musculus	129-140
10515876-11	1999	Sialidase digestion and removal of terminal sialic acid residues from HUVEC or THP-1 cells but not from platelets abolished the platelet mediated augmentation of THP-1 cell adhesion.	N-Acetylneuraminic Acid	44-55	GLI family zinc finger 2	Homo sapiens	162-167
10610356-4	1999	Sn-Fc was found to bind specifically and in a sialic acid-dependent manner to the breast cancer cell lines MCF-7, T47.D and BT-20 both in solid- and solution-phase binding assays.	N-Acetylneuraminic Acid	46-57	sialic acid binding Ig like lectin 1	Homo sapiens	0-2
10571009-3	1999	Due to the deficiency of terminal N-acetylneuraminic acid or sialic acid, the glycan changes can be observed in serum transferrin or other glycoproteins using isoelectrofocusing with immunofixation as the most widely used diagnostic technique.	N-Acetylneuraminic Acid	34-57	transferrin	Homo sapiens	118-129
10571009-3	1999	Due to the deficiency of terminal N-acetylneuraminic acid or sialic acid, the glycan changes can be observed in serum transferrin or other glycoproteins using isoelectrofocusing with immunofixation as the most widely used diagnostic technique.	N-Acetylneuraminic Acid	61-72	transferrin	Homo sapiens	118-129
10546830-6	1999	This method was successfully applied to the analysis of sialic acid in human urinary trypsin inhibitor (hu-UTI), bovine alpha1-acid glycoprotein (alpha1-AGP) and recombinant human erythropoietin (rhu-EPO).	N-Acetylneuraminic Acid	56-67	alpha-1-acid glycoprotein	Bos taurus	120-144
10546830-6	1999	This method was successfully applied to the analysis of sialic acid in human urinary trypsin inhibitor (hu-UTI), bovine alpha1-acid glycoprotein (alpha1-AGP) and recombinant human erythropoietin (rhu-EPO).	N-Acetylneuraminic Acid	56-67	alpha-1-acid glycoprotein	Bos taurus	146-156
10546830-6	1999	This method was successfully applied to the analysis of sialic acid in human urinary trypsin inhibitor (hu-UTI), bovine alpha1-acid glycoprotein (alpha1-AGP) and recombinant human erythropoietin (rhu-EPO).	N-Acetylneuraminic Acid	56-67	erythropoietin	Homo sapiens	180-194
10546830-6	1999	This method was successfully applied to the analysis of sialic acid in human urinary trypsin inhibitor (hu-UTI), bovine alpha1-acid glycoprotein (alpha1-AGP) and recombinant human erythropoietin (rhu-EPO).	N-Acetylneuraminic Acid	56-67	erythropoietin	Homo sapiens	200-203
10521536-1	1999	Hepatic expression of CMP-NeuAc:Gal beta 1,4GlcNAc alpha 2,6-sialyltransferase (ST6Gal I) is induced as part of the acute phase response in mammals by mechanisms that remain poorly understood.	N-Acetylneuraminic Acid	26-31	beta galactoside alpha 2,6 sialyltransferase 1	Mus musculus	80-88
10497249-2	1999	UDP-GlcNAc 2-epimerase/N-acetylmannosamine kinase has been shown to be the key enzyme of N-acetylneuraminic acid biosynthesis in rat liver, and it is a regulator of cell surface sialylation.	N-Acetylneuraminic Acid	89-112	renin binding protein	Rattus norvegicus	4-22
10815993-0	1999	In vitro biological activities of glycosylated human interleukin-1alpha, neoglyco IL-1alpha, coupled with N-acetylneuraminic acid.	N-Acetylneuraminic Acid	106-129	interleukin 1 alpha	Homo sapiens	53-71
10502675-2	1999	The cell attachment of most animal rotaviruses, which belong to the neuraminidase-sensitive strains, requires sialic acid residues on the host cell membranes.	N-Acetylneuraminic Acid	110-121	neuraminidase 1	Homo sapiens	68-81
10499918-5	1999	Similar to other sialoadhesin molecules, p75/AIRM1 appears to mediate sialic acid-dependent ligand recognition.	N-Acetylneuraminic Acid	70-81	sialic acid binding Ig like lectin 1	Homo sapiens	17-29
10499918-5	1999	Similar to other sialoadhesin molecules, p75/AIRM1 appears to mediate sialic acid-dependent ligand recognition.	N-Acetylneuraminic Acid	70-81	sialic acid binding Ig like lectin 7	Homo sapiens	41-44
10499918-5	1999	Similar to other sialoadhesin molecules, p75/AIRM1 appears to mediate sialic acid-dependent ligand recognition.	N-Acetylneuraminic Acid	70-81	sialic acid binding Ig like lectin 7	Homo sapiens	45-50
10815986-0	1999	Synthesis of glycosylated human interleukin-1alpha, neoglyco IL-1alpha, coupled with N-acetylneuraminic acid.	N-Acetylneuraminic Acid	85-108	interleukin 1 alpha	Homo sapiens	32-50
10815986-1	1999	In order to develop glycosylated cytokine, recombinant human IL-1alpha was chemically modified with N-acetylneuraminic acid (NANA).	N-Acetylneuraminic Acid	100-123	interleukin 1 alpha	Homo sapiens	61-70
10505212-9	1999	In conclusion, the Lp(a) is one of the acute phase reactants whose synthesis concurrently increases with other APRs, especially those with a high sialic acid content.	N-Acetylneuraminic Acid	146-157	lipoprotein(a)	Homo sapiens	19-24
10815993-1	1999	In the previous study, N-acetylneuraminic acid (NANA) with C9 spacer was chemically coupled to human recombinant (rh) IL-1alpha in order to study the effect of glycosylation on its biological activities, and to develop IL-1 with less deleterious effects.	N-Acetylneuraminic Acid	23-46	interleukin 1 alpha	Homo sapiens	118-127
10815993-1	1999	In the previous study, N-acetylneuraminic acid (NANA) with C9 spacer was chemically coupled to human recombinant (rh) IL-1alpha in order to study the effect of glycosylation on its biological activities, and to develop IL-1 with less deleterious effects.	N-Acetylneuraminic Acid	23-46	interleukin 1 alpha	Homo sapiens	118-122
10453033-4	1999	Removing both alpha 2,6- and alpha 2,3-linked sialic acids from IL-1 + IL-4-costimulated HUVEC by sialidase significantly increased VCAM-1-dependent adhesion, whereas removing alpha 2,3-linked sialic acid alone had no effect; adenovirus-mediated overexpression of ST6N with costimulation almost abolished the adhesion, which was reversible by sialidase.	N-Acetylneuraminic Acid	46-57	vascular cell adhesion molecule 1	Homo sapiens	132-138
10453033-4	1999	Removing both alpha 2,6- and alpha 2,3-linked sialic acids from IL-1 + IL-4-costimulated HUVEC by sialidase significantly increased VCAM-1-dependent adhesion, whereas removing alpha 2,3-linked sialic acid alone had no effect; adenovirus-mediated overexpression of ST6N with costimulation almost abolished the adhesion, which was reversible by sialidase.	N-Acetylneuraminic Acid	46-57	interleukin 1 alpha	Homo sapiens	64-68
10428856-2	1999	We report the expression cloning of a novel leptin-binding protein of the immunoglobulin superfamily (OB-BP1) and a cross-hybridizing clone (OB-BP2) that is identical to a recently described sialic acid-binding I-type lectin called Siglec-5.	N-Acetylneuraminic Acid	191-202	sialic acid binding Ig like lectin 5	Homo sapiens	141-147
10453033-4	1999	Removing both alpha 2,6- and alpha 2,3-linked sialic acids from IL-1 + IL-4-costimulated HUVEC by sialidase significantly increased VCAM-1-dependent adhesion, whereas removing alpha 2,3-linked sialic acid alone had no effect; adenovirus-mediated overexpression of ST6N with costimulation almost abolished the adhesion, which was reversible by sialidase.	N-Acetylneuraminic Acid	46-57	interleukin 4	Homo sapiens	71-75
10455130-8	1999	Increased C2GnT expression also led to masking of the SM-3 peptide epitope, which persisted after the removal of sialic acid, further suggesting greater complexity of the core 2-associated O-glycans on MUC1.	N-Acetylneuraminic Acid	113-124	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	10-15
10444252-5	1999	Lectin mapping of the carbohydrates present on pigeon intestinal mucin demonstrated high levels of exposed N-acetyl neuraminic acid, N-acetyl galactosamine and N-acetyl glucosamine, with lower levels of fucose and some galactose.	N-Acetylneuraminic Acid	107-131	LOC100508689	Homo sapiens	65-70
10425361-13	1999	These results suggest that the sialic acid part of Epo entrapped in liposomes may project out from liposomes, depending on the entrapped Epo concentration.	N-Acetylneuraminic Acid	31-42	erythropoietin	Rattus norvegicus	51-54
10425361-13	1999	These results suggest that the sialic acid part of Epo entrapped in liposomes may project out from liposomes, depending on the entrapped Epo concentration.	N-Acetylneuraminic Acid	31-42	erythropoietin	Rattus norvegicus	137-140
10425209-2	1999	Meanwhile, the removal of sialic acid from IgA1 accelerated the aggregation of the IgA1 molecule [J.	N-Acetylneuraminic Acid	26-37	immunoglobulin heavy constant alpha 1	Homo sapiens	43-47
10425209-2	1999	Meanwhile, the removal of sialic acid from IgA1 accelerated the aggregation of the IgA1 molecule [J.	N-Acetylneuraminic Acid	26-37	immunoglobulin heavy constant alpha 1	Homo sapiens	83-87
10434049-2	1999	The ManNAc generated by the action of N-acetyl-D-glucosamine (GlcNAc) and UDP-GlcNAc 2"-epimerases is condensed with pyruvate through the action of N-acetylneuraminate lyase and the sialic acid released is measured by the thiobarbituric acid assay.	N-Acetylneuraminic Acid	182-193	N-acetylneuraminate pyruvate lyase	Homo sapiens	148-173
10488950-11	1999	Enzymatic removal of sialic acid from LDL with neuraminidase resulted in an increase in LDL-APG complex formation.	N-Acetylneuraminic Acid	21-32	neuraminidase 1	Homo sapiens	47-60
10488951-10	1999	Plasma sialic acid concentration correlated with C-reactive protein (r = 0.58, P = 0.0001), serum triglyceride (r = 0.32, P = 0.002), and blood cholesterol concentration (r = 0.22, P = 0.04).	N-Acetylneuraminic Acid	7-18	C-reactive protein	Homo sapiens	49-67
10468987-0	1999	Growth hormone (GH) replacement therapy reduces serum sialic acid concentrations in adults with GH-deficiency: a double-blind placebo-controlled study.	N-Acetylneuraminic Acid	54-65	growth hormone 1	Homo sapiens	0-14
10404908-1	1999	CONTEXT: The neuraminidase inhibitor zanamivir, a sialic acid analog administered directly to the respiratory tract, has been demonstrated in clinical studies to be effective in treatment of type A and B influenza.	N-Acetylneuraminic Acid	50-61	neuraminidase 1	Homo sapiens	13-26
10468987-11	1999	Before GH replacement therapy SA concentrations correlated positively with the patients age (r = 0.45; P &lt; 0.04) and fasting insulin concentrations (r = 0.5; P &lt; 0.03) but not with fasting lipid profile.	N-Acetylneuraminic Acid	30-32	insulin	Homo sapiens	128-135
10393093-4	1999	The resonances corresponding to the methyl protons within the N-acetyl moiety of sialic acid undergo upfield shifting and broadening during titrations, reflecting an interaction of this group with Trp2 in sialoadhesin as observed in co-crystals of the terminal domain with bound ligand.	N-Acetylneuraminic Acid	81-92	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	197-201
10393093-4	1999	The resonances corresponding to the methyl protons within the N-acetyl moiety of sialic acid undergo upfield shifting and broadening during titrations, reflecting an interaction of this group with Trp2 in sialoadhesin as observed in co-crystals of the terminal domain with bound ligand.	N-Acetylneuraminic Acid	81-92	sialic acid binding Ig like lectin 1	Homo sapiens	205-217
10415045-7	1999	Our data also show that the recognition of CD43 and CD45RB by 1B11 is differentially affected by O-linked glycosylation and sialic acid.	N-Acetylneuraminic Acid	124-135	sialophorin	Mus musculus	43-47
10415045-7	1999	Our data also show that the recognition of CD43 and CD45RB by 1B11 is differentially affected by O-linked glycosylation and sialic acid.	N-Acetylneuraminic Acid	124-135	protein tyrosine phosphatase, receptor type, C	Mus musculus	52-66
10415045-8	1999	Whereas 1B11 recognition of CD43 on activated T cells required both core 2 O-glycan branching and sialic acid, 1B11 recognition of CD45 only occurred in the absence of both core 2 glycosylation and sialic acid.	N-Acetylneuraminic Acid	98-109	sialophorin	Mus musculus	28-32
10400772-1	1999	Influenza A viruses possess two glycoprotein spikes on the virion surface: hemagglutinin (HA), which binds to oligosaccharides containing terminal sialic acid, and neuraminidase (NA), which removes terminal sialic acid from oligosaccharides.	N-Acetylneuraminic Acid	207-218	neuraminidase 1	Homo sapiens	164-177
10460894-1	1999	Recent studies have suggested the occurrence of an abnormal form of uromodulin in stone formers which may be related to a reduced sialic acid content of the protein in these patients.	N-Acetylneuraminic Acid	130-141	uromodulin	Homo sapiens	68-78
10460894-6	1999	Desialated uromodulin showed a series of bands ranging from pI 4.0 to 5.1 reflecting different amounts of sialic acid removed.	N-Acetylneuraminic Acid	106-117	uromodulin	Homo sapiens	11-21
10425545-1	1999	The objective of this study was the evaluation of the relation between the N-acetyl-neuraminic acid-binding endogenous lectin sarcolectin and the cytokine macrophage migration inhibitory factor (MIF) during development of rheumatoid nodules (RN) in seropositive rheumatoid arthritis (RA).	N-Acetylneuraminic Acid	75-99	keratin 7	Homo sapiens	126-137
19003352-1	1999	The human Golgi enzyme CMP-NeuAc:Gal(beta1-4)GlcNAc-R alpha2,6-sialyltransferase (ST6N) was stably coexpressed with human erythropoietin (EPO) from a BHK-21A cell line.	N-Acetylneuraminic Acid	27-32	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	82-86
19003352-1	1999	The human Golgi enzyme CMP-NeuAc:Gal(beta1-4)GlcNAc-R alpha2,6-sialyltransferase (ST6N) was stably coexpressed with human erythropoietin (EPO) from a BHK-21A cell line.	N-Acetylneuraminic Acid	27-32	erythropoietin	Homo sapiens	122-136
10619706-1	1999	GM3-synthase, also known as sialyltransferase I (ST-I), catalyzes the transfer of a sialic acid residue from CMP-sialic acid onto lactosylceramide to form ganglioside GM3.	N-Acetylneuraminic Acid	84-95	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	0-12
10619706-1	1999	GM3-synthase, also known as sialyltransferase I (ST-I), catalyzes the transfer of a sialic acid residue from CMP-sialic acid onto lactosylceramide to form ganglioside GM3.	N-Acetylneuraminic Acid	113-124	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	0-12
10425545-1	1999	The objective of this study was the evaluation of the relation between the N-acetyl-neuraminic acid-binding endogenous lectin sarcolectin and the cytokine macrophage migration inhibitory factor (MIF) during development of rheumatoid nodules (RN) in seropositive rheumatoid arthritis (RA).	N-Acetylneuraminic Acid	75-99	macrophage migration inhibitory factor	Homo sapiens	155-193
10425545-1	1999	The objective of this study was the evaluation of the relation between the N-acetyl-neuraminic acid-binding endogenous lectin sarcolectin and the cytokine macrophage migration inhibitory factor (MIF) during development of rheumatoid nodules (RN) in seropositive rheumatoid arthritis (RA).	N-Acetylneuraminic Acid	75-99	macrophage migration inhibitory factor	Homo sapiens	195-198
10393343-1	1999	In a previous paper we showed that the B-pentamer of cholera toxin (CT-B) binds with reduced binding strength to different C(1) derivatives of N-acetylneuraminic acid (NeuAc) of the natural receptor ganglioside, GM1.	N-Acetylneuraminic Acid	143-166	phosphate cytidylyltransferase 1B, choline	Homo sapiens	68-72
10377127-7	1999	The extra- and intracellular NADPH-oxidase responses showed differences in sialic acid dependency, indicating that these two responses are mediated by different receptor structures.	N-Acetylneuraminic Acid	75-86	respiratory burst oxidase homolog protein A	Triticum aestivum	29-42
10393701-3	1999	Their specificity for GalNAc was determined by reactivity with IgA1 myeloma proteins with enzymatically removed N-acetylneuraminic acid (NeuNAc) and galactose (Gal); removal of the O-linked glycans of IgA1 resulted in significantly decreased reactivity.	N-Acetylneuraminic Acid	112-135	immunoglobulin heavy constant alpha 1	Homo sapiens	63-67
10393343-1	1999	In a previous paper we showed that the B-pentamer of cholera toxin (CT-B) binds with reduced binding strength to different C(1) derivatives of N-acetylneuraminic acid (NeuAc) of the natural receptor ganglioside, GM1.	N-Acetylneuraminic Acid	168-173	phosphate cytidylyltransferase 1B, choline	Homo sapiens	68-72
10393701-3	1999	Their specificity for GalNAc was determined by reactivity with IgA1 myeloma proteins with enzymatically removed N-acetylneuraminic acid (NeuNAc) and galactose (Gal); removal of the O-linked glycans of IgA1 resulted in significantly decreased reactivity.	N-Acetylneuraminic Acid	137-143	immunoglobulin heavy constant alpha 1	Homo sapiens	63-67
10393343-7	1999	Loss of or altered hydrogen bond interactions involving the water molecules bridging the sialic acid to the protein was found to be the major cause for the observed drop in CT-B affinity in the smaller derivatives, while in the bulkier derivatives, hydrophobic interactions with the protein were found to partly compensate for these losses.	N-Acetylneuraminic Acid	89-100	phosphate cytidylyltransferase 1B, choline	Homo sapiens	173-177
10393701-5	1999	The re-formation of isolated and acid-dissociated CICs was inhibited more effectively by IgA1 lacking NeuNAc and Gal than by intact IgA1.	N-Acetylneuraminic Acid	102-108	immunoglobulin heavy constant alpha 1	Homo sapiens	89-93
10458318-2	1999	It reacts with stable human CD43 transfectants in a sialic acid independent way and blocks completely cell binding of RDP/AD9 or 161-46 more or less but not DFT1 and MEM-59.	N-Acetylneuraminic Acid	52-63	sialophorin	Homo sapiens	28-32
10458318-2	1999	It reacts with stable human CD43 transfectants in a sialic acid independent way and blocks completely cell binding of RDP/AD9 or 161-46 more or less but not DFT1 and MEM-59.	N-Acetylneuraminic Acid	52-63	AD9	Homo sapiens	122-125
10447009-5	1999	Molecular variants of hCG with increased thyrotropic potency include basic molecules with reduced sialic acid content, truncated molecules lacking the C-terminal tail, or molecules in which the 47-48 peptide bond in the beta-subunit loop is nicked.	N-Acetylneuraminic Acid	98-109	chorionic gonadotropin subunit beta 5	Homo sapiens	22-25
10334995-2	1999	Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway.	N-Acetylneuraminic Acid	141-152	renin binding protein	Homo sapiens	57-75
10579699-2	1999	Mucins prepared from cancer tissue in adenocarcinoma showed this reduction, while normal O-acetylation was detected in resection margin and control cases and total mucin sialic acid content was significantly decreased in cancer vs. control samples.	N-Acetylneuraminic Acid	170-181	LOC100508689	Homo sapiens	164-169
10748551-3	1999	FB1 and FB21 recognize an intracytoplasmic epitope (35, 38 kD) and a sialic acid-dependent carbohydrate epitope, respectively.	N-Acetylneuraminic Acid	69-80	TCF3 fusion partner	Homo sapiens	0-3
10414519-2	1999	Here we demonstrate that the toxic effect displayed by PrP(Sc) can be blocked by sulfated colominic acid (polymer of N-acetylneuraminic acid).	N-Acetylneuraminic Acid	117-140	prion protein	Homo sapiens	55-58
10207017-6	1999	These results indicate that the expressed enzyme is a new type of GalNAcalpha2,6-sialyltransferase, which requires sialic acid residues linked to Galbeta1,3GalNAc residues for its activity; therefore, we designated it mouse ST6GalNAc IV.	N-Acetylneuraminic Acid	115-126	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4	Mus musculus	66-98
10207178-5	1999	GM3(Neu5Ac) with C18-sphingosine was the major ganglioside constituting about 90% of the whole ganglioside fraction.	N-Acetylneuraminic Acid	4-10	Bardet-Biedl syndrome 9	Homo sapiens	17-20
10225975-7	1999	B-cell rolling on E-selectin required sialic acid but was independent of previously described selectin ligands.	N-Acetylneuraminic Acid	38-49	selectin E	Homo sapiens	18-28
10225975-9	1999	Binding of this protein was strictly Ca2+ dependent, was inhibited by a cell adhesion-blocking mAb against E-selectin, and required the presence of sialic acid but not N-linked carbohydrates.	N-Acetylneuraminic Acid	148-159	selectin E	Homo sapiens	107-117
10206952-1	1999	A novel member of the human CMP-NeuAc:beta-galactoside alpha2, 3-sialyltransferase (ST) subfamily, designated ST3Gal VI, was identified based on BLAST analysis of expressed sequence tags, and a cDNA clone was isolated from a human melanoma line library.	N-Acetylneuraminic Acid	32-37	ST3 beta-galactoside alpha-2,3-sialyltransferase 6	Homo sapiens	110-119
10427856-2	1999	Among these molecules, the selectins expressed on endothelial cells (E- and P-selectins) and leucocytes (L-selectin) recognize carbohydrate ligands such as sialyl Lewis A or sialyl Lewis X oligosaccharides due to the same positioning of NeuAc, Gal and Fuc residues in both isomeric structures.	N-Acetylneuraminic Acid	237-242	selectin L	Homo sapiens	105-115
10427856-3	1999	We have shown that the sialic acid residue could be replaced by a sulfate group such as in the sulfated Lewis A pentasaccharide, one of the most potent monovalent ligand for human E-selectin, which was shown to be very active in the prevention of ischemia reperfusion lung injury.	N-Acetylneuraminic Acid	23-34	selectin E	Homo sapiens	180-190
10403191-4	1999	Thyroid weight and sialic acid content of thyroglobulin progressed with maturation.	N-Acetylneuraminic Acid	19-30	thyroglobulin	Homo sapiens	42-55
10403191-7	1999	T4 and T3 content of thyroglobulin was directly proportional to its degree of iodination and positively related to its sialic acid content.	N-Acetylneuraminic Acid	119-130	thyroglobulin	Homo sapiens	21-34
10206955-1	1999	The myeloid restricted membrane glycoprotein, CD33, is a member of the recently characterized "sialic acid-binding immunoglobulin-related lectin" family.	N-Acetylneuraminic Acid	95-106	CD33 molecule	Homo sapiens	46-50
10206955-2	1999	Although CD33 can mediate sialic acid-dependent cell interactions as a recombinant protein, its function in myeloid cells has yet to be determined.	N-Acetylneuraminic Acid	26-37	CD33 molecule	Homo sapiens	9-13
10207017-6	1999	These results indicate that the expressed enzyme is a new type of GalNAcalpha2,6-sialyltransferase, which requires sialic acid residues linked to Galbeta1,3GalNAc residues for its activity; therefore, we designated it mouse ST6GalNAc IV.	N-Acetylneuraminic Acid	115-126	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4	Mus musculus	224-236
10494110-4	1999	Here we show that a soluble, chimeric form of MAG, MAG-Fc, can bind to the neuronal cell body and neurites equally well, in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	126-137	myelin associated glycoprotein	Homo sapiens	46-49
10494110-4	1999	Here we show that a soluble, chimeric form of MAG, MAG-Fc, can bind to the neuronal cell body and neurites equally well, in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	126-137	myelin associated glycoprotein	Homo sapiens	51-54
10089214-4	1999	We found that, in addition to their common requirement of an alpha2-6 bound terminal sialic acid for binding, the antibodies displayed preferences for the length of the carbohydrate backbones.	N-Acetylneuraminic Acid	85-96	immunoglobulin binding protein 1	Homo sapiens	61-69
10235309-8	1999	These changes in the sialic acid content of Apo J were accompanied by a similar pattern of changes in the enzyme activities of hepatic sialyltransferase and plasma sialidase in animals undergoing chronic ethanol treatment, withdrawal, and abstinence periods.	N-Acetylneuraminic Acid	21-32	clusterin	Rattus norvegicus	44-49
10188726-1	1999	The activity of beta-galactoside alpha2,6-sialyltransferase (ST6Gal.1), the enzyme responsible for the addition of sialic acid in alpha2,6-linkage to N-acetyllactosaminic (Gal beta1,4GlcNAc) units of glycoconjugates, is increased in the vast majority of colon cancer specimens, and a positive correlation with an invasive phenotype has been suggested by several studies.	N-Acetylneuraminic Acid	115-126	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	61-69
10464766-4	1999	The glycoform, referred to as Peak 1, contains the O-linked glycan Neu5Ac(alpha 2-3)Gal(beta 1-3)GalNAc; the Peak 2 glycoform contains the O-linked glycan Neu5Ac(alpha 2-3)Gal(beta 1-3)[Neu5Ac(alpha 2-6)]GalNAc.	N-Acetylneuraminic Acid	67-73	pseudopodium-enriched atypical kinase 1	Mus musculus	30-36
10101298-8	1999	The binding to L-selectin was mediated by the lectin domain of L-selectin in a Ca2+-dependent manner and required heparan sulfate side chains, but not sialic acid.	N-Acetylneuraminic Acid	151-162	selectin L	Homo sapiens	15-25
10101298-8	1999	The binding to L-selectin was mediated by the lectin domain of L-selectin in a Ca2+-dependent manner and required heparan sulfate side chains, but not sialic acid.	N-Acetylneuraminic Acid	151-162	selectin L	Homo sapiens	63-73
10191360-3	1999	We find that in brain Kv1.1, Kv1.2 and Kv1.4, which have a single consensus glycosylation site in the first extracellular interhelical domain, are N-glycosylated with sialic acid-rich oligosaccharide chains.	N-Acetylneuraminic Acid	167-178	potassium voltage-gated channel subfamily A member 1	Homo sapiens	22-27
10191360-3	1999	We find that in brain Kv1.1, Kv1.2 and Kv1.4, which have a single consensus glycosylation site in the first extracellular interhelical domain, are N-glycosylated with sialic acid-rich oligosaccharide chains.	N-Acetylneuraminic Acid	167-178	potassium voltage-gated channel subfamily A member 2	Homo sapiens	29-34
10191360-3	1999	We find that in brain Kv1.1, Kv1.2 and Kv1.4, which have a single consensus glycosylation site in the first extracellular interhelical domain, are N-glycosylated with sialic acid-rich oligosaccharide chains.	N-Acetylneuraminic Acid	167-178	potassium voltage-gated channel subfamily A member 4	Homo sapiens	39-44
10365854-8	1999	A mucin staining study with O-acylated sialic acid, which is used for the demonstration of gastrointestinal, cholecystic and uterine cervical mucins, was negative for the mucin-producing epithelial cells of the cyst.	N-Acetylneuraminic Acid	39-50	LOC100508689	Homo sapiens	2-7
10353318-1	1999	The role of sialic acid linked with lipoprotein lipase (LPL) in its catalytic activity was studied.	N-Acetylneuraminic Acid	12-23	lipoprotein lipase	Homo sapiens	56-59
10096568-1	1999	The disialoganglioside GD3 is a major antigen in human melanomas that can undergo 9-O-acetylation of the outer sialic acid (giving 9-OAc-GD3).	N-Acetylneuraminic Acid	111-122	GRDX	Homo sapiens	23-26
10420586-3	1999	All of the analogues retained excellent efficiency in supporting the adhesion to myelin-associated glycoprotein (MAG), raising the possibility that the internal sialic acid linked to the GalNAc residue may be replaced by other anionic substituents, in contrast to the terminal sialic acid, which is essential for MAG binding.	N-Acetylneuraminic Acid	161-172	myelin associated glycoprotein	Homo sapiens	81-111
10420586-3	1999	All of the analogues retained excellent efficiency in supporting the adhesion to myelin-associated glycoprotein (MAG), raising the possibility that the internal sialic acid linked to the GalNAc residue may be replaced by other anionic substituents, in contrast to the terminal sialic acid, which is essential for MAG binding.	N-Acetylneuraminic Acid	161-172	myelin associated glycoprotein	Homo sapiens	113-116
10420586-3	1999	All of the analogues retained excellent efficiency in supporting the adhesion to myelin-associated glycoprotein (MAG), raising the possibility that the internal sialic acid linked to the GalNAc residue may be replaced by other anionic substituents, in contrast to the terminal sialic acid, which is essential for MAG binding.	N-Acetylneuraminic Acid	277-288	myelin associated glycoprotein	Homo sapiens	113-116
10096568-1	1999	The disialoganglioside GD3 is a major antigen in human melanomas that can undergo 9-O-acetylation of the outer sialic acid (giving 9-OAc-GD3).	N-Acetylneuraminic Acid	111-122	GRDX	Homo sapiens	137-140
10069709-1	1999	Infantile free sialic acid storage disease (ISSD) is a rare autosomal recessive metabolic disorder caused by a lysosomal membrane transport defect, resulting in accumulation of free sialic acid within lysosomes.	N-Acetylneuraminic Acid	15-26	solute carrier family 17 member 5	Homo sapiens	44-48
10349302-9	1999	Moreover, the inhibitory activity of OPN was not due to its primary structure, but it was closely related to its higher-order structure and side chains including sialic acid.	N-Acetylneuraminic Acid	162-173	secreted phosphoprotein 1	Homo sapiens	37-40
10217151-1	1999	It is well-known that microheterogeneity of human serum transferrin observed in alcoholics manifests as sialic acid-deficient transferrin isoforms, otherwise known as carbohydrate-deficient transferrin (CDT).	N-Acetylneuraminic Acid	104-115	transferrin	Homo sapiens	56-67
10217151-1	1999	It is well-known that microheterogeneity of human serum transferrin observed in alcoholics manifests as sialic acid-deficient transferrin isoforms, otherwise known as carbohydrate-deficient transferrin (CDT).	N-Acetylneuraminic Acid	104-115	transferrin	Homo sapiens	126-137
10217151-1	1999	It is well-known that microheterogeneity of human serum transferrin observed in alcoholics manifests as sialic acid-deficient transferrin isoforms, otherwise known as carbohydrate-deficient transferrin (CDT).	N-Acetylneuraminic Acid	104-115	transferrin	Homo sapiens	126-137
10024664-0	1999	Cell surface sialic acid and the regulation of immune cell interactions: the neuraminidase effect reconsidered.	N-Acetylneuraminic Acid	13-24	neuraminidase 1	Homo sapiens	77-90
10024664-4	1999	Here we show for the first time that cell surface sialic acid on medium incubated B cells blocks access to costimulatory molecules on the B cell surface, and that this is the most likely explanation for the neuraminidase effect.	N-Acetylneuraminic Acid	50-61	neuraminidase 1	Homo sapiens	207-220
10024664-6	1999	However, we cannot exclude a role for CD86-bound sialic acid on the B cell in modulating binding to T cell CD28.	N-Acetylneuraminic Acid	49-60	CD86 molecule	Homo sapiens	38-42
10024664-6	1999	However, we cannot exclude a role for CD86-bound sialic acid on the B cell in modulating binding to T cell CD28.	N-Acetylneuraminic Acid	49-60	CD28 molecule	Homo sapiens	107-111
10069709-1	1999	Infantile free sialic acid storage disease (ISSD) is a rare autosomal recessive metabolic disorder caused by a lysosomal membrane transport defect, resulting in accumulation of free sialic acid within lysosomes.	N-Acetylneuraminic Acid	182-193	solute carrier family 17 member 5	Homo sapiens	44-48
9950679-15	1999	This interaction involves the COOH terminus of the FGF-2 molecule and depends on the structure of the oligosaccharide chain and on the presence of sialic acid residue(s) in the ganglioside molecule.	N-Acetylneuraminic Acid	147-158	fibroblast growth factor 2	Homo sapiens	51-56
9949167-0	1999	Sialylation of the sialic acid binding lectin sialoadhesin regulates its ability to mediate cell adhesion.	N-Acetylneuraminic Acid	19-30	sialic acid binding Ig like lectin 1	Homo sapiens	46-58
9949167-1	1999	The macrophage-specific cell surface receptor sialoadhesin, which is a member of the newly recognized family of sialic acid binding lectins called siglecs, binds glycoprotein and glycolipid ligands containing a2-3-linked sialic acid on the surface of several leukocyte subsets.	N-Acetylneuraminic Acid	112-123	sialic acid binding Ig like lectin 1	Homo sapiens	46-58
9949167-1	1999	The macrophage-specific cell surface receptor sialoadhesin, which is a member of the newly recognized family of sialic acid binding lectins called siglecs, binds glycoprotein and glycolipid ligands containing a2-3-linked sialic acid on the surface of several leukocyte subsets.	N-Acetylneuraminic Acid	221-232	sialic acid binding Ig like lectin 1	Homo sapiens	46-58
9949167-2	1999	Recently, the sialic acid binding activity of the siglec CD22 has been demonstrated to be regulated by sialylation of the CD22 receptor molecule.	N-Acetylneuraminic Acid	14-25	CD22 molecule	Homo sapiens	57-61
9949167-2	1999	Recently, the sialic acid binding activity of the siglec CD22 has been demonstrated to be regulated by sialylation of the CD22 receptor molecule.	N-Acetylneuraminic Acid	14-25	CD22 molecule	Homo sapiens	122-126
10215318-9	1999	Furthermore, this study shows that megalin carries N-glycosidically linked hybrid and complex-type oligosaccharides terminating with sialic acid.	N-Acetylneuraminic Acid	133-144	LDL receptor related protein 2	Rattus norvegicus	35-42
10037148-5	1999	The interactions of these proteins with MAG were sialic acid-dependent and specific for MAG.	N-Acetylneuraminic Acid	49-60	myelin-associated glycoprotein	Mus musculus	40-43
10037148-5	1999	The interactions of these proteins with MAG were sialic acid-dependent and specific for MAG.	N-Acetylneuraminic Acid	49-60	myelin-associated glycoprotein	Mus musculus	88-91
9989767-10	1999	This abnormality of IgA1 could bear considerable implication on the pathogenesis of IgAN, because the masking effect of sialic acid may hinder the clearance of polymeric IgA1 by the asialoglycoprotein receptor (ASGP-R) of the liver cells.	N-Acetylneuraminic Acid	120-131	immunoglobulin heavy constant alpha 1	Homo sapiens	20-24
9989767-10	1999	This abnormality of IgA1 could bear considerable implication on the pathogenesis of IgAN, because the masking effect of sialic acid may hinder the clearance of polymeric IgA1 by the asialoglycoprotein receptor (ASGP-R) of the liver cells.	N-Acetylneuraminic Acid	120-131	IGAN1	Homo sapiens	84-88
9989767-10	1999	This abnormality of IgA1 could bear considerable implication on the pathogenesis of IgAN, because the masking effect of sialic acid may hinder the clearance of polymeric IgA1 by the asialoglycoprotein receptor (ASGP-R) of the liver cells.	N-Acetylneuraminic Acid	120-131	immunoglobulin heavy constant alpha 1	Homo sapiens	170-174
10830921-5	1999	vWF sialic acid content was determined by a lectin-based ELISA.	N-Acetylneuraminic Acid	4-15	von Willebrand factor	Homo sapiens	0-3
10189832-9	1999	Both gram-positive rods, streptococci, and Veillonella species from the subgingival microflora induce an altered immunoelectrophoretic mobility of IgA1 indicative of removal of terminally positioned sialic acid.	N-Acetylneuraminic Acid	199-210	immunoglobulin heavy constant alpha 1	Homo sapiens	147-151
10189832-10	1999	Quantitative determination of residual carbohydrate content of IgA1 after incubation with bacterial cells of Gram-positive rods has confirmed that they remove sialic acid, and in addition to that, only minor amounts of carbohydrates.	N-Acetylneuraminic Acid	159-170	immunoglobulin heavy constant alpha 1	Homo sapiens	63-67
10190023-8	1999	As a glycoprotein, thyroglobulin contains 8-10% total carbohydrate with galactose, mannose, fucose, N-acetyl glucosamine and sialic acid residues.	N-Acetylneuraminic Acid	125-136	thyroglobulin	Homo sapiens	19-32
10580651-5	1999	Our results show that the increase in [Ca2+]i may be caused by not the number of sialic acids contained in the gangliosides but the conformation of the sialic acid moiety to protrude exteriorly from the liposomal membrane surface, and that a sort of receptor recognizing the sialic acid moiety exists on human T lymphocytes (both CD8+ and CD4+ cells), which may be involved in the activation of the cells.	N-Acetylneuraminic Acid	152-163	CD8a molecule	Homo sapiens	330-333
10580651-5	1999	Our results show that the increase in [Ca2+]i may be caused by not the number of sialic acids contained in the gangliosides but the conformation of the sialic acid moiety to protrude exteriorly from the liposomal membrane surface, and that a sort of receptor recognizing the sialic acid moiety exists on human T lymphocytes (both CD8+ and CD4+ cells), which may be involved in the activation of the cells.	N-Acetylneuraminic Acid	152-163	CD4 molecule	Homo sapiens	339-342
9972868-8	1999	We found that GM1 ganglioside exhibited higher affinity for A beta 1-40 than GA1, suggesting that the sialic acid moiety of GM1 is necessary for its interaction with A beta.	N-Acetylneuraminic Acid	102-113	amyloid beta precursor protein	Homo sapiens	60-66
9972868-8	1999	We found that GM1 ganglioside exhibited higher affinity for A beta 1-40 than GA1, suggesting that the sialic acid moiety of GM1 is necessary for its interaction with A beta.	N-Acetylneuraminic Acid	102-113	amyloid beta precursor protein	Homo sapiens	166-172
10075584-5	1999	Finally, monocyte adhesion and activation were measured after culture with a porcine endothelial cell line transfected with alpha(1,2)-fucosyltransferase, expressing reduced surface expression of terminal Gal alpha(1,3)-Gal and sialic acid residues.	N-Acetylneuraminic Acid	228-239	fucosyltransferase 2	Homo sapiens	124-153
10075584-9	1999	Porcine endothelial cell transfection with alpha(1,2)-fucosyltransferase reduced terminal sialic acid expression by 65%, monocyte adherence by 50%, and the production of PGE2 and IL-1beta by 67% and 38%, respectively.	N-Acetylneuraminic Acid	90-101	fucosyltransferase 2	Homo sapiens	43-72
10609502-6	1999	A significant correlation has been found between serum total SA content and CA125 level in patients with undifferentiated ovarian cancers.	N-Acetylneuraminic Acid	61-63	mucin 16, cell surface associated	Homo sapiens	76-81
10830921-7	1999	The mean vWF sialic acid content of the PPH patients corresponded to 37.7% of the mean value for the control group.	N-Acetylneuraminic Acid	13-24	von Willebrand factor	Homo sapiens	9-12
9826427-3	1998	The soluble hST8Sia III protein expressed in COS-7 showed an extremely high catalytic activity of transferring sialic acid through alpha2,8-linkage to intact fetuin glycoprotein, whereas the transferring activity was completely undetectable toward either alpha2,6-sialylated glycoprotein or desialylated glycoprotein acceptors.	N-Acetylneuraminic Acid	111-122	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	Homo sapiens	12-23
10580634-3	1999	CD43 is the major sialic acid rich protein on the surface of lymphocytes.	N-Acetylneuraminic Acid	18-29	sialophorin	Homo sapiens	0-4
9837919-5	1998	In contrast, all of the TSHRs synthesized in mutant CHO-Lec1, 2, and 8 cells (mannose-rich, sialic acid-deficient, and galactose-deficient oligosaccharides, respectively) bound TSH and produced cAMP in response to TSH with an affinity and an EC50 similar to those in TSHR expressed in parental CHO cells (CHO-TSHR; sialylated oligosaccharides).	N-Acetylneuraminic Acid	92-103	thyrotropin receptor	Cricetulus griseus	24-28
9920397-13	1998	Analysis of purified RTI40 shows that the protein contains glycan, some of which is sialic acid.	N-Acetylneuraminic Acid	84-95	podoplanin	Rattus norvegicus	21-26
29711309-1	1998	A novel immobilization procedure for glycoproteins is based on the reacion of immobilized CMP-NeuAc (CMP-sialic acids) with sialyltransferase (see scheme).	N-Acetylneuraminic Acid	94-99	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	124-141
9834131-6	1998	Enzymatic removal of N-linked glycosylation did not significantly modulate ICAM-1 cleavage by HLE, while removal of sialic acid residues partially reduced the sensitivity of ICAM-1 to HLE.	N-Acetylneuraminic Acid	116-127	intercellular adhesion molecule 1	Homo sapiens	174-180
9874234-3	1998	Using oligosaccharides with modifications in the sialic acid, galactose or N-acetylglucosamine moieties, we could demonstrate that both MAG and Sn bind with high preference to alpha2,3-linked sialic acid and interact at least with the three terminal monosaccharide units.	N-Acetylneuraminic Acid	49-60	myelin associated glycoprotein	Homo sapiens	136-139
9874234-3	1998	Using oligosaccharides with modifications in the sialic acid, galactose or N-acetylglucosamine moieties, we could demonstrate that both MAG and Sn bind with high preference to alpha2,3-linked sialic acid and interact at least with the three terminal monosaccharide units.	N-Acetylneuraminic Acid	192-203	myelin associated glycoprotein	Homo sapiens	136-139
9874234-5	1998	Also, an additional sialic acid at position six of the third-terminal monosaccharide unit enhances binding to MAG, whereas it does not influence binding to Sn significantly.	N-Acetylneuraminic Acid	20-31	myelin associated glycoprotein	Homo sapiens	110-113
9874234-8	1998	These results indicate that the interactions of MAG and Sn are mainly with sialic acid and that additional contacts with the subterminal galactose and N-acetylglucosamine residues also contribute to the binding strength, although to a lesser degree.	N-Acetylneuraminic Acid	75-86	myelin associated glycoprotein	Homo sapiens	48-51
9863654-8	1998	Neuraminidase (0.01 i.u./10(7) platelets), which strips sialic acid residues from membrane glycoproteins, abolished the promoting effect of platelets on tube formation.	N-Acetylneuraminic Acid	56-67	neuraminidase 1	Homo sapiens	0-13
9832639-10	1998	Since oligosaccharide chain alterations such as reduced sialic acid and galactose of IgA1 molecule have been reported in IgA nephropathy patients, MBP might bind to the IgA1 molecule via interaction between MBP and sugar chain.	N-Acetylneuraminic Acid	56-67	myelin basic protein	Homo sapiens	147-150
9832639-10	1998	Since oligosaccharide chain alterations such as reduced sialic acid and galactose of IgA1 molecule have been reported in IgA nephropathy patients, MBP might bind to the IgA1 molecule via interaction between MBP and sugar chain.	N-Acetylneuraminic Acid	56-67	immunoglobulin heavy constant alpha 1	Homo sapiens	169-173
9813391-10	1998	The agglutination was abolished by sialidase treatment of the red cells and immunoblotting with slot-blotted mucin showed that binding was both acid and sialidase sensitive indicating the involvement of sialic acid in the binding site.	N-Acetylneuraminic Acid	203-214	LOC100508689	Homo sapiens	109-114
10197075-13	1998	At puberty serum SHBG not only falls in concentration but also has an altered sialic acid content which modulates its circulating half-life.	N-Acetylneuraminic Acid	78-89	sex hormone binding globulin	Homo sapiens	17-21
9813391-11	1998	These studies show that CAM 17.1 binds to a sialic-acid-containing determinant of mucin, probably sialyl-I, which epitope shows wide distribution throughout the gastro-intestinal tract.	N-Acetylneuraminic Acid	44-55	LOC100508689	Homo sapiens	82-87
9774483-5	1998	PST and STX were found to add polysialic acid on NCAM.Fc molecules sialylated by alpha-2,3- or alpha-2,6-linkage in vitro, but not on NCAM.Fc lacking either sialic acid.	N-Acetylneuraminic Acid	34-45	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	0-3
9870409-2	1998	It consists of a group of minor isoforms of human transferrin (the main iron transport serum protein) deficient in sialic acid groups (asialo, monosialo and disialo) with a pI &gt; 5.7, while the main isotransferrin (tetrasialo) has a pI of 5.4.	N-Acetylneuraminic Acid	115-126	transferrin	Homo sapiens	50-61
9751794-0	1998	Identification of the glycosidically bound sialic acid in mucin glycoproteins that reacts as "free sialic acid" in the Warren assay.	N-Acetylneuraminic Acid	43-54	mucin 1, cell surface associated	Bos taurus	58-63
9751794-0	1998	Identification of the glycosidically bound sialic acid in mucin glycoproteins that reacts as "free sialic acid" in the Warren assay.	N-Acetylneuraminic Acid	99-110	mucin 1, cell surface associated	Bos taurus	58-63
9774483-5	1998	PST and STX were found to add polysialic acid on NCAM.Fc molecules sialylated by alpha-2,3- or alpha-2,6-linkage in vitro, but not on NCAM.Fc lacking either sialic acid.	N-Acetylneuraminic Acid	34-45	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	8-11
9774483-5	1998	PST and STX were found to add polysialic acid on NCAM.Fc molecules sialylated by alpha-2,3- or alpha-2,6-linkage in vitro, but not on NCAM.Fc lacking either sialic acid.	N-Acetylneuraminic Acid	34-45	neural cell adhesion molecule 1	Homo sapiens	49-53
10211703-8	1998	Since both sialic acid and fucose reportedly are crucial requirements for selectin binding, these results suggest that only a minor portion, approximately 4.5%, of the O-linked oligosaccharides on PSGL-1 are involved in the interaction with the selectins.	N-Acetylneuraminic Acid	11-22	selectin P ligand	Homo sapiens	197-203
9719680-12	1998	The abundance of sialic acid in SPACR suggests that this glycoprotein may contribute substantially to the polyanionic nature of the IPM.	N-Acetylneuraminic Acid	17-28	interphotoreceptor matrix proteoglycan 1	Homo sapiens	32-37
9873990-11	1998	MAbs HI247 and CSLEX-1 did not react in ELISA with immobilized CD11/CD18, suggesting that the majority of sialyl Lewis x on CD11/CD18 molecules may have sialic acid 6-linked rather than 3-linked to galactose.	N-Acetylneuraminic Acid	153-164	integrin subunit beta 2	Homo sapiens	129-133
10211702-4	1998	Fuc-TVII showed higher affinity toward two analogs, in which the hydroxyl group at C-6 of GlcNAc has been deoxygenated and the acetamide group of N-acetylneuraminic acid has been replaced with a glycolylamino group, respectively, than that toward the original compound.	N-Acetylneuraminic Acid	146-169	fucosyltransferase 7	Homo sapiens	0-8
9771885-3	1998	Oligosaccharide chains, containing N-acetylglucosamine, mannose, galactose and sialic acid were found on recombinant gp51-p30.	N-Acetylneuraminic Acid	79-90	centromere protein V	Homo sapiens	122-125
9764851-12	1998	This is another terminal sialic acid moiety expressed by the 180 kd CD45 isoform of memory T cells but not by monocytes/macrophages.	N-Acetylneuraminic Acid	25-36	protein tyrosine phosphatase receptor type C	Homo sapiens	68-72
9740323-0	1998	Role of sialic acid in the endocytosis of prosaposin by the nonciliated cells of the rat efferent ducts.	N-Acetylneuraminic Acid	8-19	prosaposin	Rattus norvegicus	42-52
9740323-12	1998	Moreover, Western blots of prosaposin isolated from seminiferous tubular fluids followed by glycan analysis with Sambucus nigra agglutinin (SNA) and Maackia amurensis agglutinin (MAA), revealed that this protein has sialic acid residues that are terminally linked to galactose and/or N-acetylgalactosamine (alpha-NeuNAc-[2-&gt;6]-Gal and alpha-NeuNAc-[2-&gt;6]-GalNAc).	N-Acetylneuraminic Acid	216-227	prosaposin	Rattus norvegicus	27-37
9740323-13	1998	These data indicate that testicular prosaposin is removed from the lumen of the efferent ducts by the noncialiated cells via a receptor that recognizes prosaposin"s terminal sialic acid residues.	N-Acetylneuraminic Acid	174-185	prosaposin	Rattus norvegicus	36-46
9740323-13	1998	These data indicate that testicular prosaposin is removed from the lumen of the efferent ducts by the noncialiated cells via a receptor that recognizes prosaposin"s terminal sialic acid residues.	N-Acetylneuraminic Acid	174-185	prosaposin	Rattus norvegicus	152-162
9721187-5	1998	Recently, a p62-like protein isolated from mouse neuroblastoma cells was reported to be modified by both GlcNAc and sialic acid.	N-Acetylneuraminic Acid	116-127	nucleoporin 62	Mus musculus	12-15
9731071-6	1998	When siglec-5 was expressed on COS cells or as a recombinant protein fused to the Fc region of human IgG1, it was able to mediate sialic acid-dependent binding to human erythrocytes and soluble glycoconjugates, suggesting that it may be involved in cell-cell interactions.	N-Acetylneuraminic Acid	130-141	sialic acid binding Ig like lectin 5	Homo sapiens	5-13
9671214-5	1998	We conclude that hypersialylation of DPP-IV modifies surface charge of the CD26 antigen, promoting binding of HIV peptides through their cationic domains to the sialic acid residues of DPP-IV, and that certain HIV moieties are likely to engage this phenomenon as an auxiliary adhesion mechanism to fuse with cells.	N-Acetylneuraminic Acid	161-172	dipeptidyl peptidase 4	Homo sapiens	37-43
9731194-1	1998	Upon removal of its sialic acid or galactose residue, vitamin D-binding protein (DBP) becomes a potent macrophage-activating factor, DBP-MAF.	N-Acetylneuraminic Acid	20-31	GC vitamin D binding protein	Homo sapiens	54-79
9731194-1	1998	Upon removal of its sialic acid or galactose residue, vitamin D-binding protein (DBP) becomes a potent macrophage-activating factor, DBP-MAF.	N-Acetylneuraminic Acid	20-31	D-box binding PAR bZIP transcription factor	Homo sapiens	81-84
9716150-4	1998	Mass measurements of intact Kaiserslautern gamma chains after neuraminidase treatment of the native fibrinogen confirmed a total of three residues of sialic acid in the dominant isoform.	N-Acetylneuraminic Acid	150-161	fibrinogen beta chain	Homo sapiens	100-110
9716150-7	1998	It appears that the polymerisation defect of this fibrinogen results from electrostatic repulsion between condensing protofibrils and that this is induced by the two new residues of sialic acid that are present on the new gamma chain.	N-Acetylneuraminic Acid	182-193	fibrinogen beta chain	Homo sapiens	50-60
9781857-5	1998	Consequently, the increases in haptoglobin and hemopexin were marked and 90% or more of the increased sialic acid was derived from these two glycoproteins after exposure to UV radiation.	N-Acetylneuraminic Acid	102-113	haptoglobin	Mus musculus	31-42
10052592-1	1998	The biosynthesis of the sialic acid N-glycolylneuraminic acid (Neu5Gc) occurs by the action of cytidine monophosphate-N-acetylneuraminate (CMP-Neu5Ac) hydroxylase.	N-Acetylneuraminic Acid	24-35	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	139-162
10052596-12	1998	Therefore, the blockade of CCK-induced alterations in membrane glycoconjugates enriched in N-acetyl glucosamine and sialic acid of newly formed granules after pancreatitis, a finding that could explain the delay in the regression of the disease.	N-Acetylneuraminic Acid	116-127	cholecystokinin	Rattus norvegicus	27-30
9770342-3	1998	Myelin-associated glycoprotein (MAG), a sialic acid binding protein, is a potent inhibitor of neurite outgrowth when presented to neurons in culture.	N-Acetylneuraminic Acid	40-51	myelin associated glycoprotein	Homo sapiens	0-30
9770342-3	1998	Myelin-associated glycoprotein (MAG), a sialic acid binding protein, is a potent inhibitor of neurite outgrowth when presented to neurons in culture.	N-Acetylneuraminic Acid	40-51	myelin associated glycoprotein	Homo sapiens	32-35
9738906-7	1998	In the case of MAG, N-fluoroacetylneuraminic acid is bound about 17-fold better than N-acetylneuraminic acid.	N-Acetylneuraminic Acid	85-108	myelin associated glycoprotein	Homo sapiens	15-18
9658077-7	1998	In addition to a somewhat reduced affinity for 6"-sialyl(N-acetyllactosamine)-containing receptors, horse serum-resistant variants lost the ability to bind the viral neuraminidase-resistant 4-O-acetylated sialic acid moieties of equine alpha2-macroglobulin because of the mutation 145N--&gt;K/D in their HA1.	N-Acetylneuraminic Acid	205-216	alpha-2-macroglobulin	Equus caballus	236-256
9658077-10	1998	Avian strains bound 4-O-acetylated sialic acid residues of equine alpha2-macroglobulin, whereas equine strains did not.	N-Acetylneuraminic Acid	35-46	alpha-2-macroglobulin	Equus caballus	66-86
9671214-5	1998	We conclude that hypersialylation of DPP-IV modifies surface charge of the CD26 antigen, promoting binding of HIV peptides through their cationic domains to the sialic acid residues of DPP-IV, and that certain HIV moieties are likely to engage this phenomenon as an auxiliary adhesion mechanism to fuse with cells.	N-Acetylneuraminic Acid	161-172	dipeptidyl peptidase 4	Homo sapiens	185-191
10099302-2	1998	In this study, the incomplete intracellular sialylation of interferon-gamma (IFN-gamma), produced by Chinese hamster ovary cell culture, was minimized by supplementing the culture medium with N-acetylmannosamine (ManNAc), a direct intracellular precursor for sialic acid synthesis.	N-Acetylneuraminic Acid	259-270	interferon gamma	Cricetulus griseus	59-75
9644253-4	1998	The primary attachment site of O-acetyl groups was exclusively the hydroxyl at C-7 of Neu5Ac, the presence of an AcCoA:Neu5Ac 7-O-acetyltransferase thus being demonstrated.	N-Acetylneuraminic Acid	86-92	complement C7	Bos taurus	79-82
9644253-5	1998	After longer incubation 9-O-acetylated Neu5Ac also appeared, suggesting the migration of an ester group from C-7 to C-9.	N-Acetylneuraminic Acid	39-45	complement C7	Bos taurus	109-112
9644253-5	1998	After longer incubation 9-O-acetylated Neu5Ac also appeared, suggesting the migration of an ester group from C-7 to C-9.	N-Acetylneuraminic Acid	39-45	complement C9	Bos taurus	116-119
9668345-5	1998	MAG binding was abrogated by modification of the carboxylic acid, any hydroxyl, or the N-acetyl group of the ganglioside"s N-acetylneuraminic acid moiety.	N-Acetylneuraminic Acid	123-146	myelin associated glycoprotein	Homo sapiens	0-3
9662485-5	1998	There was a significant univariate correlation between serum total sialic acid and fasting plasma insulin.	N-Acetylneuraminic Acid	67-78	insulin	Homo sapiens	98-105
9662485-8	1998	In females there was a strong univariate correlation between serum total sialic acid and plasma fasting insulin and glucose concentrations, although in males there was a weaker univariate correlation between serum total sialic acid and fasting plasma glucose and the insulin resistance index.	N-Acetylneuraminic Acid	73-84	insulin	Homo sapiens	104-111
9662485-12	1998	In multiple regression analysis of the 100 subjects serum total sialic acid correlated independently with fasting serum cholesterol, glucose and also plasma insulin concentrations.	N-Acetylneuraminic Acid	64-75	insulin	Homo sapiens	157-164
9644260-5	1998	In this report, we demonstrate that hCST corrects the CMP-sialic acid transporter-deficient phenotype of CHO-derived Lec2 cells, as judged from the recovery of WGA-sensitivity by transformants, and the recovery of CMP-sialic acid transporting ability by microsomal vesicles prepared from them.	N-Acetylneuraminic Acid	58-69	solute carrier family 35 member A1	Homo sapiens	36-40
9636173-0	1998	Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes.	N-Acetylneuraminic Acid	29-40	CD22 molecule	Homo sapiens	68-72
9636173-0	1998	Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes.	N-Acetylneuraminic Acid	29-40	CD22 molecule	Homo sapiens	74-82
9636173-2	1998	It is also an I-type lectin (now designated Siglec-2), whose extracellular domain can specifically recognize alpha2-6-linked sialic acid (Sia) residues.	N-Acetylneuraminic Acid	138-141	CD22 molecule	Homo sapiens	44-52
9636173-7	1998	Enzymatic desialylation unmasks the CD22 lectin activity, indicating that endogenous Sia residues block the CD22 lectin-binding site.	N-Acetylneuraminic Acid	85-88	CD22 molecule	Homo sapiens	36-40
9636173-7	1998	Enzymatic desialylation unmasks the CD22 lectin activity, indicating that endogenous Sia residues block the CD22 lectin-binding site.	N-Acetylneuraminic Acid	85-88	CD22 molecule	Homo sapiens	108-112
10099302-2	1998	In this study, the incomplete intracellular sialylation of interferon-gamma (IFN-gamma), produced by Chinese hamster ovary cell culture, was minimized by supplementing the culture medium with N-acetylmannosamine (ManNAc), a direct intracellular precursor for sialic acid synthesis.	N-Acetylneuraminic Acid	259-270	interferon gamma	Cricetulus griseus	77-86
10099302-7	1998	When radiolabeled ManNAc was used to trace the incorporation of the precursor, it was found that supplemental ManNAc was exclusively incorporated into IFN-gamma as sialic acid and that, at 20 mM ManNAc feeding, nearly 100% of product sialylation originated from the supplemental precursor.	N-Acetylneuraminic Acid	164-175	interferon gamma	Cricetulus griseus	151-160
9573227-9	1998	A recombinant neuraminidase that specifically removes the alpha(2-3) linkage of sialic acid had no effect on virus binding or infection.	N-Acetylneuraminic Acid	80-91	neuraminidase 1	Homo sapiens	14-27
9706403-9	1998	When RBC treated with neuraminidase to remove 85-90% of sialic acid were treated with the cationic reagents, both adhesion between RBC and morphological change were reduced.	N-Acetylneuraminic Acid	56-67	neuraminidase 1	Homo sapiens	22-35
9629854-8	1998	IgG anti-GM1(NeuGc) antibodies in sera from the GBS patients were significantly absorbed by GM1(NeuAc), indicative that the anti-GM1(NeuGc) antibodies cross-react with GM1(NeuAc).	N-Acetylneuraminic Acid	96-101	coenzyme Q10A	Mus musculus	9-19
9629854-8	1998	IgG anti-GM1(NeuGc) antibodies in sera from the GBS patients were significantly absorbed by GM1(NeuAc), indicative that the anti-GM1(NeuGc) antibodies cross-react with GM1(NeuAc).	N-Acetylneuraminic Acid	96-101	coenzyme Q10A	Mus musculus	129-139
9629854-8	1998	IgG anti-GM1(NeuGc) antibodies in sera from the GBS patients were significantly absorbed by GM1(NeuAc), indicative that the anti-GM1(NeuGc) antibodies cross-react with GM1(NeuAc).	N-Acetylneuraminic Acid	172-177	coenzyme Q10A	Mus musculus	9-19
9629854-8	1998	IgG anti-GM1(NeuGc) antibodies in sera from the GBS patients were significantly absorbed by GM1(NeuAc), indicative that the anti-GM1(NeuGc) antibodies cross-react with GM1(NeuAc).	N-Acetylneuraminic Acid	172-177	coenzyme Q10A	Mus musculus	129-139
9629854-9	1998	N-Glycolylneuraminic acid-containing gangliosides are so highly immunogenic in humans that the injection of GM1(NeuGc) could induce the production of IgG anti-GM1(NeuGc) antibody, which cross-reacts with GM1(NeuAc).	N-Acetylneuraminic Acid	208-213	coenzyme Q10A	Mus musculus	108-118
9629854-9	1998	N-Glycolylneuraminic acid-containing gangliosides are so highly immunogenic in humans that the injection of GM1(NeuGc) could induce the production of IgG anti-GM1(NeuGc) antibody, which cross-reacts with GM1(NeuAc).	N-Acetylneuraminic Acid	208-213	coenzyme Q10A	Mus musculus	159-169
9597691-4	1998	TRK-530 also inhibited splenomegaly and suppressed the increase in serum sialic acid which is measured as a systemic parameter of inflammation.	N-Acetylneuraminic Acid	73-84	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	0-3
9584138-6	1998	Neuraminidase, trypsin or ficin treatment of human erythrocytes eliminated their ability to adhere to Plasmodium falciparum microgametes, suggesting a role of sialic acid and one or more glycophorins in the binding to a putative gamete receptor.	N-Acetylneuraminic Acid	159-170	neuraminidase 1	Homo sapiens	0-13
9584138-8	1998	We propose that either the sialic acid moiety of glycophorins, predominantly glycophorin A, or a more complex interaction involving the glycophorin peptide backbone, is the erythrocyte receptor for adhesion to microgametes.	N-Acetylneuraminic Acid	27-38	CD2 molecule	Homo sapiens	173-193
9657351-0	1998	Sialic acid content of von Willebrand factor subunit.	N-Acetylneuraminic Acid	0-11	von Willebrand factor	Homo sapiens	23-44
9676385-4	1998	Significant correlations between sialic acid and Na+, K+, ATPase (r = 0.65, p &lt; 0.001) and between sialic acid and transketolase (r = 0.58, p &lt; 0.001) were observed.	N-Acetylneuraminic Acid	33-44	TANK binding kinase 1	Homo sapiens	49-64
9676385-4	1998	Significant correlations between sialic acid and Na+, K+, ATPase (r = 0.65, p &lt; 0.001) and between sialic acid and transketolase (r = 0.58, p &lt; 0.001) were observed.	N-Acetylneuraminic Acid	102-113	transketolase	Homo sapiens	118-131
9676385-6	1998	These data show that decreases in Na+, K+, ATPase, and transketolase activities and sialic acid concentration are present in rheumatoid arthritis patients, and that the decrease in Na+, K+, ATPase and transketolase activities in rheumatoid arthritis might be due to decreased sialic acid.	N-Acetylneuraminic Acid	276-287	dynein axonemal heavy chain 8	Homo sapiens	181-196
9676385-6	1998	These data show that decreases in Na+, K+, ATPase, and transketolase activities and sialic acid concentration are present in rheumatoid arthritis patients, and that the decrease in Na+, K+, ATPase and transketolase activities in rheumatoid arthritis might be due to decreased sialic acid.	N-Acetylneuraminic Acid	276-287	transketolase	Homo sapiens	201-214
9573548-12	1998	Patient Fc alpha R had a higher Mr (60 to 85 kDa) than those of controls (55 to 75 kDa) and a decreased binding to a sialic acid-specific lectin on blots, indicating post-translational modifications with impaired sialylation of surface Fc alpha R molecules that might be involved in enhanced IgA binding.	N-Acetylneuraminic Acid	117-128	Fc alpha receptor	Homo sapiens	8-18
9545292-4	1998	270, 1497-1500) the larger L-sialylmotif of ST6Gal I was analyzed by site-directed mutagenesis, which provided evidence that it participates in the binding of the CMP-NeuAc, a common donor substrate for all the sialyltransferases.	N-Acetylneuraminic Acid	167-172	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	44-52
9672151-5	1998	Treatment with neuraminidase results in a retarded migration in SDS-PAGE, an increase in isoelectric point and a reduction in carbohydrate content, indicating a substantial content of sialic acid.	N-Acetylneuraminic Acid	184-195	neuraminidase 1	Homo sapiens	15-28
9565665-1	1998	A 2.1-kb 5"-flanking fragment of the rat CMP-NeuAc:GM3 alpha2,8 sialyltransferase (GD3-synthase) gene was cloned by the genomic walking procedure.	N-Acetylneuraminic Acid	45-50	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	83-95
9559786-11	1998	One is a change in HA1 of Ala-133 to Thr, a residue close to the binding site, while the other change was Arg-132 of HA1 to Gln, which in HA1 of serotype H3 is a sialic acid contact (Asn-137).	N-Acetylneuraminic Acid	162-173	Rho GTPase activating protein 45	Homo sapiens	117-120
9669459-9	1998	After 4 months, the activity of enzymes hydrolyzing N(alpha)-benzoyl-DL-arginyl-p-nitroaniline was significantly reduced in all groups, while the levels of free sialic acid were reduced in group X-PD only (P &lt; 0.05).	N-Acetylneuraminic Acid	161-172	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	195-199
9558106-8	1998	VAP-1 supported sialic acid-dependent adhesion under shear stress, suggesting that VAP-1 and ICAM-1 mediate, respectively, tethering and firm adhesion.	N-Acetylneuraminic Acid	16-27	amine oxidase copper containing 3	Homo sapiens	0-5
9558106-8	1998	VAP-1 supported sialic acid-dependent adhesion under shear stress, suggesting that VAP-1 and ICAM-1 mediate, respectively, tethering and firm adhesion.	N-Acetylneuraminic Acid	16-27	amine oxidase copper containing 3	Homo sapiens	83-88
9558106-8	1998	VAP-1 supported sialic acid-dependent adhesion under shear stress, suggesting that VAP-1 and ICAM-1 mediate, respectively, tethering and firm adhesion.	N-Acetylneuraminic Acid	16-27	intercellular adhesion molecule 1	Homo sapiens	93-99
9559786-11	1998	One is a change in HA1 of Ala-133 to Thr, a residue close to the binding site, while the other change was Arg-132 of HA1 to Gln, which in HA1 of serotype H3 is a sialic acid contact (Asn-137).	N-Acetylneuraminic Acid	162-173	Rho GTPase activating protein 45	Homo sapiens	19-22
9559786-11	1998	One is a change in HA1 of Ala-133 to Thr, a residue close to the binding site, while the other change was Arg-132 of HA1 to Gln, which in HA1 of serotype H3 is a sialic acid contact (Asn-137).	N-Acetylneuraminic Acid	162-173	Rho GTPase activating protein 45	Homo sapiens	117-120
9586577-0	1998	Importance of sialic acid in recombinant thrombomodulin in terms of pharmacokinetics and separation of desialyzed glycoprotein.	N-Acetylneuraminic Acid	14-25	thrombomodulin	Mus musculus	41-55
9497351-5	1998	Affinity labeling using sialyl-Lewisx in which the sialic acid has been mildly oxidized has been used to verify this switch in specificity and to show that the sialic acid-containing portion of the ligand interacts near the sequence Lys-Lys-Lys corresponding to residues 111-113 of E-selectin.	N-Acetylneuraminic Acid	160-171	selectin E	Homo sapiens	282-292
29645229-16	1998	Sialic acid content in choriocarcinoma hCG was extremely lower compared to that in normal hCG.	N-Acetylneuraminic Acid	0-11	hypertrichosis 2 (generalised, congenital)	Homo sapiens	39-42
9531293-1	1998	Complement factor H (fH) regulates activation of the alternative pathway of C, reducing the amount of C3b deposited on sialic acid-rich surfaces.	N-Acetylneuraminic Acid	119-130	complement factor H	Homo sapiens	11-19
9833611-16	1998	Sialic acid content in choriocarcinoma hCG was extremely lower compared to that in normal hCG.	N-Acetylneuraminic Acid	0-11	hypertrichosis 2 (generalised, congenital)	Homo sapiens	39-42
9520287-1	1998	Our previous studies have revealed that gastric and esophageal cancer patients with abnormal sialic acid levels had a better response than those with normal levels if they received polysaccharide K (PSK), a nonspecific immunomodulator.	N-Acetylneuraminic Acid	93-104	TAO kinase 2	Homo sapiens	199-202
10193487-2	1998	To reduce the electrostatic repulsive force, due mainly to sialic acid of the membrane glycoproteins, human erythrocytes were treated with neuraminidase.	N-Acetylneuraminic Acid	59-70	neuraminidase 1	Homo sapiens	139-152
9520199-5	1998	RESULTS: The migration of the ocular mucins on SDS-PAGE stopped after treatment with neuraminidase, which removes the terminal negatively charged sialic acid residues from mucin.	N-Acetylneuraminic Acid	146-157	neuraminidase 1	Homo sapiens	85-98
9580152-5	1998	The results indicate that the loss of sialic acid from the hCG molecule slightly increases the binding activity to LH receptors and results in steroidogenic activity with an increased ED50.	N-Acetylneuraminic Acid	38-49	chorionic gonadotropin subunit beta 5	Homo sapiens	59-62
9520199-5	1998	RESULTS: The migration of the ocular mucins on SDS-PAGE stopped after treatment with neuraminidase, which removes the terminal negatively charged sialic acid residues from mucin.	N-Acetylneuraminic Acid	146-157	LOC100508689	Homo sapiens	37-42
9526071-3	1998	Sialic acid residues in clusterin may be responsible for its structural conformation, stability and functional ability.	N-Acetylneuraminic Acid	0-11	clusterin	Rattus norvegicus	24-33
9561779-6	1998	All mucin preparations contained high amounts of N-acetyl-glucosamine, galactose, N-acetyl-galactosamine, fucose and sialic acid, saccharides typical of the O-linked carbohydrate side chains.	N-Acetylneuraminic Acid	117-128	LOC100508689	Homo sapiens	4-9
9544450-5	1998	The bone ALP showed a rapid initial clearance, apparently related to its large glycan heterogeneity and to the presence of molecules with a low sialic acid content.	N-Acetylneuraminic Acid	144-155	ATHS	Homo sapiens	9-12
9523722-5	1998	Part of the ATP-binding site of GlcNAc kinase was identified by sequence comparison with related hexokinases, including the bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (EC 5.1.3.14/2.7.1.60), the key enzyme of N-acetylneuraminic acid biosynthesis in rat liver.	N-Acetylneuraminic Acid	251-272	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	144-206
9544805-0	1998	Influence of the nature of coupling agents on insulin adsorption on supports grafted with sialic acid for high-performance affinity chromatography.	N-Acetylneuraminic Acid	90-101	insulin	Homo sapiens	46-53
9442118-7	1998	Four distinct oligosaccharide structures were found to effect CD44-mediated HA binding: (a) the terminal alpha2,3-linked sialic acid on N-linked oligosaccharides inhibited binding; (b) the first N-linked N-acetylglucosamine residue enhanced binding; (c) O-linked glycans on N-deglycosylated CD44 enhanced binding; and (d) N-acetylgalactosamine incorporation into non-N-linked glycans augmented HA binding by cell surface CD44.	N-Acetylneuraminic Acid	121-132	CD44 antigen	Cricetulus griseus	62-66
9516657-6	1998	Isoforms lacking one to eight of four to eight possible sialic acid residues were found in AT, TBG and Tf in all cases, with variable intensity and frequency, and in all except one patient in alpha(1)-AT.	N-Acetylneuraminic Acid	56-67	serpin family A member 7	Homo sapiens	95-98
9516657-6	1998	Isoforms lacking one to eight of four to eight possible sialic acid residues were found in AT, TBG and Tf in all cases, with variable intensity and frequency, and in all except one patient in alpha(1)-AT.	N-Acetylneuraminic Acid	56-67	transferrin	Homo sapiens	103-105
9446670-7	1998	However, neuraminidase treatment completely blocked HL-60 rolling on L-selectin, but not P-selectin, suggesting L-selectin and P-selectin ligand activities have different contributions of sialic acid.	N-Acetylneuraminic Acid	188-199	neuraminidase 1	Homo sapiens	9-22
9541617-1	1998	The Hemagglutinin-Neuraminidase (HN) from "La Piedad, Michoacan" porcine rubulavirus (LPMV) interacts specifically with NeuAc alpha 2,3 lactose residues on the target cell.	N-Acetylneuraminic Acid	120-125	neuraminidase 1	Homo sapiens	18-31
9492296-4	1998	CD45 consists of several isoforms which were isolated after cell surface sialic acid residues were labeled by periodate/NaB3H4 treatment.	N-Acetylneuraminic Acid	73-84	protein tyrosine phosphatase receptor type C	Homo sapiens	0-4
9500871-1	1998	The specific removal of negatively-charged sialic acid by neuraminidase produces a large increase in cardiac myocyte Ca uptake (17.3 +/- 1.1 mmol Ca/kg dry weight) and marked cell contracture.	N-Acetylneuraminic Acid	43-54	neuraminidase 1	Homo sapiens	58-71
9754811-2	1998	The serum level of one variant which lacks terminal galactose and sialic acid (agalactosyl IgG) is raised in a number of autoimmune diseases and animal models thereof.	N-Acetylneuraminic Acid	66-77	immunoglobulin heavy chain (S107 family)	Mus musculus	91-94
9438414-9	1998	Since GNPDA is the sole enzyme linking hexosamine systems with glycolytic pathways, we propose that it provides a source of energy in the form of phosphosugar derived from the catabolism of hexosamines found in glycoproteins, glycolipids, and sialic acid-containing macromolecules.	N-Acetylneuraminic Acid	243-254	glucosamine-6-phosphate deaminase 1	Homo sapiens	6-11
9438414-10	1998	Evidence that GNPDA can regulate hexosamine stores comes from our observation that transfection of GNPDA into HEK-293 cells reduces cellular levels of sialic acid.	N-Acetylneuraminic Acid	151-162	glucosamine-6-phosphate deaminase 1	Homo sapiens	14-19
9438414-10	1998	Evidence that GNPDA can regulate hexosamine stores comes from our observation that transfection of GNPDA into HEK-293 cells reduces cellular levels of sialic acid.	N-Acetylneuraminic Acid	151-162	glucosamine-6-phosphate deaminase 1	Homo sapiens	99-104
9427508-1	1997	Polysialyltransferase (PST) is an enzyme that catalyzes the addition of polysialic acid (PSA), a homopolymer of alpha-2,8-linked sialic acid residues, onto neural cell adhesion molecule (NCAM).	N-Acetylneuraminic Acid	76-87	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Rattus norvegicus	0-21
9443938-3	1998	The molar ratio of sialic acid to galactose residues on tetrameric human serum butyrylcholinesterase, recombinant human butyrylcholinesterase, and recombinant mouse acetylcholinesterase was found to be approximately 1.0.	N-Acetylneuraminic Acid	19-30	acetylcholinesterase	Mus musculus	165-185
9422094-13	1998	Our results suggest that sialic acid residues on the MUC1 mucin may contribute either positively or negatively to antibody binding.	N-Acetylneuraminic Acid	25-36	mucin 1, cell surface associated	Homo sapiens	53-57
9422094-13	1998	Our results suggest that sialic acid residues on the MUC1 mucin may contribute either positively or negatively to antibody binding.	N-Acetylneuraminic Acid	25-36	LOC100508689	Homo sapiens	58-63
9400621-0	1997	Sialyl-Lewis(x) sequence 6-O-sulfated at N-acetylglucosamine rather than at galactose is the preferred ligand for L-selectin and de-N-acetylation of the sialic acid enhances the binding strength.	N-Acetylneuraminic Acid	153-164	selectin L	Homo sapiens	114-124
9858465-3	1998	Neuraminidase pretreatment of pharyngeal epithelial cells resulted in a significant decrease in NTHI attachment, suggesting sialic acid as an important component of the receptor.	N-Acetylneuraminic Acid	124-135	neuraminidase 1	Homo sapiens	0-13
9501410-1	1998	BACKGROUND AND OBJECTIVES: Pr1,2,3, PrM, Sa and Sia-l1, -b1, -lb1 are sialic acid (NeuNAc)-dependent antigens recognized by human cold agglutinins.	N-Acetylneuraminic Acid	70-81	neuraminidase 1	Homo sapiens	48-59
9559530-4	1998	These data suggest that incomplete removal of sialic acid residues by viral neuraminidase N1 in some reassortants results in re-attachment of virions to the infected cells and thus impairs the virus dissemination, which may be regarded as a reassortant-limiting factor probably significant for virus evolution.	N-Acetylneuraminic Acid	46-57	neuraminidase 1	Homo sapiens	76-89
9447247-9	1997	Reaction of r-vWF with carbohydrate-specific lectins demonstrated that r-vWF contained a high proportion of N-glycans composed of mannose, galactose, glucose, N-acetylglucosamine and terminal sialic acid.	N-Acetylneuraminic Acid	192-203	von Willebrand factor	Homo sapiens	73-76
9486427-0	1997	Comparison between intact and desialylated human serum amyloid P component by laser photo CIDNP (chemically induced dynamic nuclear polarization) technique: an indication for a conformational impact of sialic acid.	N-Acetylneuraminic Acid	202-213	amyloid P component, serum	Homo sapiens	49-74
9486427-11	1997	Therefore, the removal of sialic acid moieties from the single N-glycan of each monomer apparently affects surface presentation of distinct CIDNP-reactive amino acids of SAP [1].	N-Acetylneuraminic Acid	26-37	amyloid P component, serum	Homo sapiens	170-173
9524927-3	1997	Concanavalin A lectin affinity chromatography was used to analyse apolipoprotein H according to the characteristics of its carbohydrate chain inner to sialic acid residues.	N-Acetylneuraminic Acid	151-162	apolipoprotein H	Homo sapiens	66-82
9413256-1	1997	IgM paraproteins from patients with CANOMAD (chronic ataxic neuropathy, ophthalmoplegia, M-protein, agglutination, anti-disialosyl antibodies) react with NeuAc(alpha 2-8)NeuAc epitopes on a wide range of gangliosides including GQ1b, GT1a, GD1b and GD3.	N-Acetylneuraminic Acid	154-159	myomesin 2	Homo sapiens	89-98
9427508-1	1997	Polysialyltransferase (PST) is an enzyme that catalyzes the addition of polysialic acid (PSA), a homopolymer of alpha-2,8-linked sialic acid residues, onto neural cell adhesion molecule (NCAM).	N-Acetylneuraminic Acid	76-87	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Rattus norvegicus	23-26
9427508-1	1997	Polysialyltransferase (PST) is an enzyme that catalyzes the addition of polysialic acid (PSA), a homopolymer of alpha-2,8-linked sialic acid residues, onto neural cell adhesion molecule (NCAM).	N-Acetylneuraminic Acid	76-87	neural cell adhesion molecule 1	Rattus norvegicus	156-185
9427508-1	1997	Polysialyltransferase (PST) is an enzyme that catalyzes the addition of polysialic acid (PSA), a homopolymer of alpha-2,8-linked sialic acid residues, onto neural cell adhesion molecule (NCAM).	N-Acetylneuraminic Acid	76-87	neural cell adhesion molecule 1	Rattus norvegicus	187-191
9367184-6	1997	As a result, it was revealed that the Tg fraction eluted at higher ionic strength from a DEAE-cellulose column is apt to contain more of each iodoamino acid, as well as total content of iodine, larger negative zeta-potential, conforming to sialic acid content in the Tg molecule and to a higher content of di-sialo-bi-antennary complex and to high mannose type oligosaccharides.	N-Acetylneuraminic Acid	240-251	thyroglobulin	Homo sapiens	38-40
9375892-11	1997	Indeed, the binding of the sialic acid-specific elderberry lectin to IgA1 was significantly lower in HSP compared to controls (p = 0.004).	N-Acetylneuraminic Acid	27-38	immunoglobulin heavy constant alpha 1	Homo sapiens	69-73
9406434-8	1997	Sialic acid-induced heterogeneity has been documented for many enzymes, but neuraminidase treatment can often remove sialic acids and produce gel patterns that are easier to interpret.	N-Acetylneuraminic Acid	0-11	neuraminidase 1	Homo sapiens	76-89
9325301-5	1997	CAB4 recognizes core alpha1,6 fucose regardless of terminal sugars, branching pattern, sialic acid linkage, or polylactosamine substitution.	N-Acetylneuraminic Acid	87-98	calcium voltage-gated channel auxiliary subunit beta 4	Homo sapiens	0-4
9352687-3	1997	A portion of each THP sample was treated with the enzyme neuraminidase to yield the low sialic acid form of the protein.	N-Acetylneuraminic Acid	88-99	neuraminidase 1	Homo sapiens	57-70
9331085-11	1997	This general increase in alpha2,6 sialylation on all glycoproteins is due to the increased activity of the galactoside:alpha2,6 sialyltransferase (ST6Gal I), which specifically transfers Neu5Ac residues in alpha2,6 linkage to Gal beta1,4GlcNAc units on N-glycans.	N-Acetylneuraminic Acid	187-193	beta galactoside alpha 2,6 sialyltransferase 1	Mus musculus	147-155
9376117-7	1997	Neuraminidase pretreatment of cells to remove sialic acid residues prior to viral adsorption increased the efficiency of gene transfer two- to five-fold in human airway and MDCK cells, and in a xenograft model of human airway.	N-Acetylneuraminic Acid	46-57	neuraminidase 1	Homo sapiens	0-13
9403845-6	1997	Thus, the terminal sialic acid residue linked to the wild-type LOS inhibited C3b deposition on the meningocuccus.	N-Acetylneuraminic Acid	19-30	endogenous retrovirus group K member 3	Homo sapiens	77-80
9363440-1	1997	The Neu1 locus, in the S region of the murine histocompatibility-2 complex, regulates the sialic acid content of several liver lysosomal enzymes.	N-Acetylneuraminic Acid	90-101	neuraminidase 1	Mus musculus	4-8
9349585-6	1997	Indeed, removal of the sialic acid or carbohydrate residues from native hCG transformed it into a thyroid stimulator that elicited a maximal response in terms of iodide uptake, organification and T3 secretion by human thyroid follicles as high as TSH and almost twice as high as native hCG.	N-Acetylneuraminic Acid	23-34	chorionic gonadotropin subunit beta 5	Homo sapiens	72-75
9349585-6	1997	Indeed, removal of the sialic acid or carbohydrate residues from native hCG transformed it into a thyroid stimulator that elicited a maximal response in terms of iodide uptake, organification and T3 secretion by human thyroid follicles as high as TSH and almost twice as high as native hCG.	N-Acetylneuraminic Acid	23-34	chorionic gonadotropin subunit beta 5	Homo sapiens	286-289
9349585-9	1997	hCG, and to a greater extent ds-hCG and dg-hCG, inhibited, as did TSH, gamma-interferon-induced human leukocyte antigen-DR (HLA-DR) expression in human thyrocytes, again reflecting the intrinsic thyrotropic activity of native hCG and its variants depleted of sialic acid or carbohydrate residues.	N-Acetylneuraminic Acid	259-270	chorionic gonadotropin subunit beta 5	Homo sapiens	0-3
9349585-9	1997	hCG, and to a greater extent ds-hCG and dg-hCG, inhibited, as did TSH, gamma-interferon-induced human leukocyte antigen-DR (HLA-DR) expression in human thyrocytes, again reflecting the intrinsic thyrotropic activity of native hCG and its variants depleted of sialic acid or carbohydrate residues.	N-Acetylneuraminic Acid	259-270	chorionic gonadotropin subunit beta 5	Homo sapiens	32-35
9349585-9	1997	hCG, and to a greater extent ds-hCG and dg-hCG, inhibited, as did TSH, gamma-interferon-induced human leukocyte antigen-DR (HLA-DR) expression in human thyrocytes, again reflecting the intrinsic thyrotropic activity of native hCG and its variants depleted of sialic acid or carbohydrate residues.	N-Acetylneuraminic Acid	259-270	chorionic gonadotropin subunit beta 5	Homo sapiens	32-35
9349585-9	1997	hCG, and to a greater extent ds-hCG and dg-hCG, inhibited, as did TSH, gamma-interferon-induced human leukocyte antigen-DR (HLA-DR) expression in human thyrocytes, again reflecting the intrinsic thyrotropic activity of native hCG and its variants depleted of sialic acid or carbohydrate residues.	N-Acetylneuraminic Acid	259-270	chorionic gonadotropin subunit beta 5	Homo sapiens	32-35
9349585-11	1997	The study was conducted in a serum-free culture system of human thyroid follicles and shows that removal of the sialic acid or carbohydrate residues from native hCG transform hCG variants into thyroid stimulating superagonists.	N-Acetylneuraminic Acid	112-123	chorionic gonadotropin subunit beta 5	Homo sapiens	161-164
9349585-11	1997	The study was conducted in a serum-free culture system of human thyroid follicles and shows that removal of the sialic acid or carbohydrate residues from native hCG transform hCG variants into thyroid stimulating superagonists.	N-Acetylneuraminic Acid	112-123	chorionic gonadotropin subunit beta 5	Homo sapiens	175-178
9298990-0	1997	Myelin-associated glycoprotein interacts with neurons via a sialic acid binding site at ARG118 and a distinct neurite inhibition site.	N-Acetylneuraminic Acid	60-71	myelin associated glycoprotein	Homo sapiens	0-30
9298990-2	1997	Myelin-associated glycoprotein (MAG), a sialic acid binding protein and a component of myelin, is a potent inhibitor of neurite outgrowth from a variety of neurons both in vitro and in vivo.	N-Acetylneuraminic Acid	40-51	myelin associated glycoprotein	Homo sapiens	0-30
9298990-2	1997	Myelin-associated glycoprotein (MAG), a sialic acid binding protein and a component of myelin, is a potent inhibitor of neurite outgrowth from a variety of neurons both in vitro and in vivo.	N-Acetylneuraminic Acid	40-51	myelin associated glycoprotein	Homo sapiens	32-35
9298990-3	1997	Here, we show that MAG"s sialic acid binding site is distinct from its neurite inhibitory activity.	N-Acetylneuraminic Acid	25-36	myelin associated glycoprotein	Homo sapiens	19-22
9298990-4	1997	Alone, sialic acid-dependent binding of MAG to neurons is insufficient to effect inhibition of axonal growth.	N-Acetylneuraminic Acid	7-18	myelin associated glycoprotein	Homo sapiens	40-43
9305887-2	1997	Biosynthesis of N-acetylneuraminic acid (Neu5Ac), a prominent component of glycoconjugates, is initiated by the action of UDP-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase, EC 5.1.	N-Acetylneuraminic Acid	16-39	renin binding protein	Rattus norvegicus	163-181
9305887-2	1997	Biosynthesis of N-acetylneuraminic acid (Neu5Ac), a prominent component of glycoconjugates, is initiated by the action of UDP-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase, EC 5.1.	N-Acetylneuraminic Acid	41-47	renin binding protein	Rattus norvegicus	163-181
9305887-14	1997	UDP-GlcNAc 2-epimerase was feedback inhibited by CMP-Neu5Ac.	N-Acetylneuraminic Acid	53-59	renin binding protein	Rattus norvegicus	4-22
9305888-3	1997	Biosynthesis of Neu5Ac is initiated and regulated by its key enzyme, UDP-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase, EC 5.1.	N-Acetylneuraminic Acid	16-22	renin binding protein	Rattus norvegicus	110-128
9350282-10	1997	The results indicate that the inhibition by SAP is due to steric effects when SAP binds to terminal mannose on oligosaccharides localized close to the sialic acid-binding site of the HA trimer.	N-Acetylneuraminic Acid	151-162	amyloid P component, serum	Homo sapiens	44-47
9350282-10	1997	The results indicate that the inhibition by SAP is due to steric effects when SAP binds to terminal mannose on oligosaccharides localized close to the sialic acid-binding site of the HA trimer.	N-Acetylneuraminic Acid	151-162	amyloid P component, serum	Homo sapiens	78-81
9298990-7	1997	Consistent with this model, mutation of arginine 118 (R118) in MAG to either alanine or aspartate abolishes its sialic acid-dependent binding.	N-Acetylneuraminic Acid	112-123	myelin associated glycoprotein	Homo sapiens	63-66
9298990-9	1997	Hence, MAG has two recognition sites for neurons, the sialic acid binding site at R118 and a distinct inhibition site which is absent from the first three Ig domains.	N-Acetylneuraminic Acid	54-65	myelin associated glycoprotein	Homo sapiens	7-10
9284129-1	1997	The erythrocyte binding antigen EBA-175 is a 175-kDa Plasmodium falciparum protein which mediates merozoite invasion of erythrocytes in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	138-149	erythrocyte binding antigen-175	Plasmodium falciparum 3D7	32-39
9322640-7	1997	Also, we found that incubation of decidual cells with various concentrations of lipoteichoic acid, sialic acid, lipopolysaccharide, and lipid A resulted in significant concentration-dependent increases in decidual cell macrophage inflammatory protein-1 alpha and interleukin-8 production (p &lt; 0.05.)	N-Acetylneuraminic Acid	99-110	C-C motif chemokine ligand 3	Homo sapiens	219-258
9322640-7	1997	Also, we found that incubation of decidual cells with various concentrations of lipoteichoic acid, sialic acid, lipopolysaccharide, and lipid A resulted in significant concentration-dependent increases in decidual cell macrophage inflammatory protein-1 alpha and interleukin-8 production (p &lt; 0.05.)	N-Acetylneuraminic Acid	99-110	C-X-C motif chemokine ligand 8	Homo sapiens	263-276
9265639-6	1997	Analysis of the secreted apoE by one- and two-dimensional gel electrophoresis and immunoblotting showed that the nascent apoE is heavily modified with carbohydrate chains containing sialic acid.	N-Acetylneuraminic Acid	182-193	apolipoprotein E	Homo sapiens	25-29
9391290-9	1997	IL-6 was associated with raised fibrinogen, sialic acid, and triglycerides.	N-Acetylneuraminic Acid	44-55	interleukin 6	Homo sapiens	0-4
9278308-1	1997	CD43 is a leukocyte membrane glycoprotein rich in negatively charged sialic acid residues that may act as an anti-adhesion molecule.	N-Acetylneuraminic Acid	69-80	sialophorin	Homo sapiens	0-4
9265639-6	1997	Analysis of the secreted apoE by one- and two-dimensional gel electrophoresis and immunoblotting showed that the nascent apoE is heavily modified with carbohydrate chains containing sialic acid.	N-Acetylneuraminic Acid	182-193	apolipoprotein E	Homo sapiens	121-125
9201997-1	1997	Sialic acid linkage and substructure requirements for binding of myelin-associated glycoprotein, Schwann cell myelin protein, and sialoadhesin.	N-Acetylneuraminic Acid	0-11	myelin associated glycoprotein	Homo sapiens	65-95
9244386-10	1997	High-pH anion-exchange chromatography analysis indicated that the recombinant forms of BSSL contained similar types of N-glycan structures differing mainly in their content of sialic acid and by the absence of fucose residues.	N-Acetylneuraminic Acid	176-187	carboxyl ester lipase	Homo sapiens	87-91
9244386-12	1997	This was in contrast to the recombinant forms of BSSL which contained mainly short type O-glycans with a high content of sialic acid.	N-Acetylneuraminic Acid	121-132	carboxyl ester lipase	Homo sapiens	49-53
9298687-3	1997	Amongst the STn specific MAbs only the B195.3 MAb shows absolute dependence on the presence of sialic acid and specificity to the simple disaccharide NANAA alpha2-6-GalNAc.	N-Acetylneuraminic Acid	95-106	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	12-15
9298693-3	1997	These proteins, collectively known as the sialoadhesin family, are able to mediate sialic acid-dependent binding with distinct specificities for both the type of sialic acid and its linkage to subterminal sugars.	N-Acetylneuraminic Acid	83-94	sialic acid binding Ig like lectin 1	Homo sapiens	42-54
9298693-3	1997	These proteins, collectively known as the sialoadhesin family, are able to mediate sialic acid-dependent binding with distinct specificities for both the type of sialic acid and its linkage to subterminal sugars.	N-Acetylneuraminic Acid	162-173	sialic acid binding Ig like lectin 1	Homo sapiens	42-54
9201997-1	1997	Sialic acid linkage and substructure requirements for binding of myelin-associated glycoprotein, Schwann cell myelin protein, and sialoadhesin.	N-Acetylneuraminic Acid	0-11	sialic acid binding Ig like lectin 1	Homo sapiens	130-142
9201997-9	1997	Deoxy and/or methoxy derivatives of the 4-, 7-, 8-, or 9-position of sialic acid attenuated or eliminated binding of MAG, as did replacement of the sialic acid acetamido group with a hydroxyl.	N-Acetylneuraminic Acid	69-80	myelin associated glycoprotein	Homo sapiens	117-120
9217067-0	1997	Roles of N-glycans with alpha2,6 as well as alpha2,3 linked sialic acid in infection by polyoma virus.	N-Acetylneuraminic Acid	60-71	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	44-52
9201997-9	1997	Deoxy and/or methoxy derivatives of the 4-, 7-, 8-, or 9-position of sialic acid attenuated or eliminated binding of MAG, as did replacement of the sialic acid acetamido group with a hydroxyl.	N-Acetylneuraminic Acid	148-159	myelin associated glycoprotein	Homo sapiens	117-120
9249051-5	1997	The present NMR study reports assignments of 1H and 13C resonances of the bound saccharidic chain NeuNAc(alpha2-3)Gal(beta1-3)[NeuNAc(alpha2-6)]GalNAc, where NeuNAc represents N-acetylneuraminic acid, and demonstrates the alpha-anomeric configuration of the N-acetylgalactosamine-threonine linkage.	N-Acetylneuraminic Acid	176-199	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	118-125
9249051-5	1997	The present NMR study reports assignments of 1H and 13C resonances of the bound saccharidic chain NeuNAc(alpha2-3)Gal(beta1-3)[NeuNAc(alpha2-6)]GalNAc, where NeuNAc represents N-acetylneuraminic acid, and demonstrates the alpha-anomeric configuration of the N-acetylgalactosamine-threonine linkage.	N-Acetylneuraminic Acid	176-199	immunoglobulin binding protein 1	Homo sapiens	134-142
9219327-4	1997	In vitro, soluble vWF is activated to bind to platelets by nonphysiological modulators, such as the bacterial glycopeptide, ristocetin, or the snake venom protein, botrocetin, or by removal of negatively-charged sialic acid residues.	N-Acetylneuraminic Acid	212-223	von Willebrand factor	Homo sapiens	18-21
21432455-6	1997	Thus the change rate of sialic acids (SA) increased significantly in both the IL-6 unchanged and increased groups.	N-Acetylneuraminic Acid	38-40	interleukin 6	Homo sapiens	78-82
9182658-1	1997	The alpha2,3 sialyltransferase, alpha2,3 SAT (O), catalyzes the transfer of sialic acid to Galbeta1,3 N-acetyl-D-galactosamine (GalNAc) (core-1) in mucin type O-glycosylation, and thus terminates chain extension.	N-Acetylneuraminic Acid	76-87	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	13-30
9393962-6	1997	It has also been shown by X-ray crystallography that glycosylated residues (specifically sialic acid) are influential in the contacts of the CH1 to CH2 as well as the CH2 to CH2 domains in a human IgG1 antibody.	N-Acetylneuraminic Acid	89-100	immediate early response 2	Mus musculus	141-144
9226930-2	1997	The hydrophilic glycoprotein is identified as alpha 1-acid glycoprotein (AGP), orosomucoid, by co-injection methods with human AGP and by reaction with neuraminidase which released N-acetylneuraminic acid.	N-Acetylneuraminic Acid	181-204	neuraminidase 1	Homo sapiens	152-165
9249154-4	1997	A recent crystal structure for influenza viral neuraminidase with sialic acid bound shows that the sialic acid is in a boat conformation [Prot Struct Funct Genet 14: 327 (1992)].	N-Acetylneuraminic Acid	66-77	neuraminidase 1	Homo sapiens	47-60
9249154-4	1997	A recent crystal structure for influenza viral neuraminidase with sialic acid bound shows that the sialic acid is in a boat conformation [Prot Struct Funct Genet 14: 327 (1992)].	N-Acetylneuraminic Acid	99-110	neuraminidase 1	Homo sapiens	47-60
9189858-6	1997	Furthermore, to reveal the detailed binding sites in the interaction, the same inhibition assays were performed using the following substances composing the IgA1 hinge glycopeptide: galactose (Gal), N-acetyl-galactosamine (GalNAc), Gal beta 1-3GalNAc, sialic acid, tetrapeptide PTPS, and synthesized hinge proline-rich peptide PVPSTPPTPSPSTPPTPSPS (sHP).	N-Acetylneuraminic Acid	252-263	immunoglobulin heavy constant alpha 1	Homo sapiens	157-161
9189858-11	1997	These results suggested that the IgA1-IgA1 interaction could be mediated by the core structure including the peptide and the sugars, except for sialic acid in the hinge region, resulting in the formation of the circulating macromolecular IgA1 in IgA nephropathy.	N-Acetylneuraminic Acid	144-155	immunoglobulin heavy constant alpha 1	Homo sapiens	38-42
9189858-11	1997	These results suggested that the IgA1-IgA1 interaction could be mediated by the core structure including the peptide and the sugars, except for sialic acid in the hinge region, resulting in the formation of the circulating macromolecular IgA1 in IgA nephropathy.	N-Acetylneuraminic Acid	144-155	immunoglobulin heavy constant alpha 1	Homo sapiens	38-42
9393962-6	1997	It has also been shown by X-ray crystallography that glycosylated residues (specifically sialic acid) are influential in the contacts of the CH1 to CH2 as well as the CH2 to CH2 domains in a human IgG1 antibody.	N-Acetylneuraminic Acid	89-100	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	197-201
9188808-7	1997	Our results suggest that glycoconjugates of zymogen granule membrane involved in CCK-regulated exocytosis contain N-acetylglucosamine and sialic acid residues whose quantities are regulated by CCK.	N-Acetylneuraminic Acid	138-149	cholecystokinin	Rattus norvegicus	81-84
9153251-11	1997	The known inhibitors of the interaction of alpha-dystroglycan with laminin-1, including EDTA, sulfatide, fucoidan, dextran sulfate, heparin, and sialic acid, also perturbed the adhesion of RT4 cells to laminin-1, whereas the reagents which do not inhibit the interaction, including dextran, chondroitin sulfate, dermatan sulfate, and GlcNAc, did not.	N-Acetylneuraminic Acid	145-156	dystroglycan 1	Homo sapiens	49-61
9188808-7	1997	Our results suggest that glycoconjugates of zymogen granule membrane involved in CCK-regulated exocytosis contain N-acetylglucosamine and sialic acid residues whose quantities are regulated by CCK.	N-Acetylneuraminic Acid	138-149	cholecystokinin	Rattus norvegicus	193-196
9210297-0	1997	1H NMR analysis of novel sialylated and fucosylated lactose-based oligosaccharides having linear GlcNAc(beta 1-6) Gal and Neu5Ac(alpha 2-6) GlcNAc sequences.	N-Acetylneuraminic Acid	122-128	immunoglobulin binding protein 1	Homo sapiens	129-138
9177294-5	1997	Thus, the presence of sialic acid containing mannose-rich carbohydrate moiety near the antigen binding site of a monoclonal antibody Fab fragment is relevant for defining antibody specificity.	N-Acetylneuraminic Acid	22-33	FA complementation group B	Homo sapiens	133-136
9210297-4	1997	The third oligosaccharide has Neu5Ac(alpha 2-6) linked to GlcNAc of the trisaccharide GlcNAc(beta 1-3)Gal(beta 1-4)Glc.	N-Acetylneuraminic Acid	30-36	immunoglobulin binding protein 1	Homo sapiens	37-46
9153413-1	1997	It has been reported previously that oncogenically transformed cells secrete different molecular forms of osteopontin (OPN), a sialic acid-rich, adhesive, phosphoglycoprotein, than OPNs secreted by their nontransformed counterparts.	N-Acetylneuraminic Acid	127-138	secreted phosphoprotein 1	Homo sapiens	106-117
9210297-4	1997	The third oligosaccharide has Neu5Ac(alpha 2-6) linked to GlcNAc of the trisaccharide GlcNAc(beta 1-3)Gal(beta 1-4)Glc.	N-Acetylneuraminic Acid	30-36	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	93-99
9210297-4	1997	The third oligosaccharide has Neu5Ac(alpha 2-6) linked to GlcNAc of the trisaccharide GlcNAc(beta 1-3)Gal(beta 1-4)Glc.	N-Acetylneuraminic Acid	30-36	tubulin beta 3 class III	Homo sapiens	106-114
9153413-1	1997	It has been reported previously that oncogenically transformed cells secrete different molecular forms of osteopontin (OPN), a sialic acid-rich, adhesive, phosphoglycoprotein, than OPNs secreted by their nontransformed counterparts.	N-Acetylneuraminic Acid	127-138	secreted phosphoprotein 1	Homo sapiens	119-122
9153413-7	1997	Taken together, these results suggest that the difference between the 69-kDa and 62-kDa isoforms of OPN resides in their sialic acid content, and sialylation of OPN is crucial for its receptor-mediated binding on tsB77 cells.	N-Acetylneuraminic Acid	121-132	secreted phosphoprotein 1	Homo sapiens	100-103
9263851-8	1997	As a test, the method predicted positions and types of important ligand fragments for neuraminidase that were in accord with the known ligand, sialic acid.	N-Acetylneuraminic Acid	143-154	neuraminidase 1	Homo sapiens	86-99
9178564-1	1997	We searched our chemical collection to identify non-N-acetylneuraminate (NeuAC) inhibitors of influenza neuraminidase (NA).	N-Acetylneuraminic Acid	52-71	neuraminidase 1	Homo sapiens	104-117
9178564-1	1997	We searched our chemical collection to identify non-N-acetylneuraminate (NeuAC) inhibitors of influenza neuraminidase (NA).	N-Acetylneuraminic Acid	52-71	neuraminidase 1	Homo sapiens	119-121
9178564-1	1997	We searched our chemical collection to identify non-N-acetylneuraminate (NeuAC) inhibitors of influenza neuraminidase (NA).	N-Acetylneuraminic Acid	73-78	neuraminidase 1	Homo sapiens	104-117
9178564-1	1997	We searched our chemical collection to identify non-N-acetylneuraminate (NeuAC) inhibitors of influenza neuraminidase (NA).	N-Acetylneuraminic Acid	73-78	neuraminidase 1	Homo sapiens	119-121
8995428-0	1997	Sialic acid specificity of myelin-associated glycoprotein binding.	N-Acetylneuraminic Acid	0-11	LOC103161439	Cricetulus griseus	27-57
9129210-3	1997	CD43 anti-adhesive effect seemed to be related to sialic acid moeties because an increase in adhesion was also induced by sialidase treatment and by monoclonal antibodies recognizing sialic acid-dependent epitopes on CD43.	N-Acetylneuraminic Acid	50-61	sialophorin	Homo sapiens	0-4
9129210-3	1997	CD43 anti-adhesive effect seemed to be related to sialic acid moeties because an increase in adhesion was also induced by sialidase treatment and by monoclonal antibodies recognizing sialic acid-dependent epitopes on CD43.	N-Acetylneuraminic Acid	50-61	sialophorin	Homo sapiens	217-221
9129210-3	1997	CD43 anti-adhesive effect seemed to be related to sialic acid moeties because an increase in adhesion was also induced by sialidase treatment and by monoclonal antibodies recognizing sialic acid-dependent epitopes on CD43.	N-Acetylneuraminic Acid	183-194	sialophorin	Homo sapiens	0-4
9129210-3	1997	CD43 anti-adhesive effect seemed to be related to sialic acid moeties because an increase in adhesion was also induced by sialidase treatment and by monoclonal antibodies recognizing sialic acid-dependent epitopes on CD43.	N-Acetylneuraminic Acid	183-194	sialophorin	Homo sapiens	217-221
9125416-3	1997	NCAMs are major carriers of sialic acid residues in the brain and removal of these with neuraminidase markedly affects the binding properties of the adhesion molecules.	N-Acetylneuraminic Acid	28-39	neuraminidase 1	Homo sapiens	88-101
9163528-7	1997	Recombinant MAH bound to the sialic acid-containing CB-II glycopeptide of human glycophorin A.	N-Acetylneuraminic Acid	29-40	glycophorin A (MNS blood group)	Homo sapiens	80-93
9084450-1	1997	Myelin-associated glycoprotein (MAG) and Schwann cell myelin protein (SMP) are highly glycosylated members of a newly defined family of cell adhesion molecules belonging to the immunoglobulin superfamily that recognize terminal sialic acid residues on N- and O-linked oligosaccharides.	N-Acetylneuraminic Acid	228-239	myelin associated glycoprotein	Homo sapiens	0-30
9084450-1	1997	Myelin-associated glycoprotein (MAG) and Schwann cell myelin protein (SMP) are highly glycosylated members of a newly defined family of cell adhesion molecules belonging to the immunoglobulin superfamily that recognize terminal sialic acid residues on N- and O-linked oligosaccharides.	N-Acetylneuraminic Acid	228-239	myelin associated glycoprotein	Homo sapiens	32-35
9155091-2	1997	Our results show that apolipoprotein H is rich in sialic acid linked alpha(2-6) to galactose or N-acetylgalactosamine.	N-Acetylneuraminic Acid	50-61	apolipoprotein H	Homo sapiens	22-38
9075335-5	1997	Similar results were obtained by direct measurements of the amount of N-acetylneuraminic acid released by neuraminidase.	N-Acetylneuraminic Acid	70-93	neuraminidase 1	Homo sapiens	106-119
9054950-1	1997	Sialidase (neuraminidase, EC 3.2.1.18) catalyses the hydrolysis of terminal sialic acid residues of glyconjugates.	N-Acetylneuraminic Acid	76-87	neuraminidase 1	Homo sapiens	11-24
9343936-1	1997	The SAT-3 activity (CMP-NeuAc:Gal beta 1-4GlcNAc beta 1-3 Gal beta 1-4Glc-ceramide alpha 2-3 sialytransferase) involved in the biosynthesis of sialy Le(x) has been characterized in human colon carcinoma cells and embryonic chicken brains.	N-Acetylneuraminic Acid	24-29	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	4-9
9343941-2	1997	N-Glycolylneuraminic acid is formed from N-acetylneuraminic acid by the action of the CMP-N-acetylneuraminic acid hydroxylase studied in various animals.	N-Acetylneuraminic Acid	41-64	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	86-125
16526129-0	1997	Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity.	N-Acetylneuraminic Acid	163-174	neuraminidase 1	Homo sapiens	10-23
16526129-4	1997	The X-ray crystallographic structure of 6h bound to NA revealed the presence of a large hydrophobic pocket in the region corresponding to the glycerol subsite of sialic acid.	N-Acetylneuraminic Acid	162-173	neuraminidase 1	Homo sapiens	52-54
9143232-5	1997	We have thereafter investigated the mechanism whereby the binding of SP to sialic acid on the MC membrane, could trigger secretion of histamine and induction of TNF-alpha mRNA.	N-Acetylneuraminic Acid	75-86	tumor necrosis factor	Rattus norvegicus	161-170
9143232-8	1997	In conclusion, the inhibitory effect of the neuraminidase on the SP-mediated increase of histamine and TNF-alpha mRNA, suggests that the SP-sialic acid interaction could have a role in the MC heterogeneous response.	N-Acetylneuraminic Acid	140-151	tumor necrosis factor	Rattus norvegicus	103-112
9130640-8	1997	Removal of the carbohydrate moiety of SP-A by N-glycosidase F treatment or cleavage of its sialic acid residues by neuraminidase abolished the enhancement of the phagocytosis of FITC-labeled influenza A virus by alveolar macrophages.	N-Acetylneuraminic Acid	91-102	surfactant protein A1	Homo sapiens	38-42
9130640-11	1997	It is concluded that SP-A acts via its sialic acid residues as an opsonin in the phagocytosis of influenza A virus by alveolar macrophages.	N-Acetylneuraminic Acid	39-50	surfactant protein A1	Homo sapiens	21-25
9068613-6	1997	Particular attention is focused on the recently evolving information about sialic acid recognition by certain C-type lectins (the selectins), I-type lectins (e.g., CD22 and sialoadhesin), and a complement regulatory protein (the H protein).	N-Acetylneuraminic Acid	75-86	CD22 molecule	Homo sapiens	164-168
9068613-6	1997	Particular attention is focused on the recently evolving information about sialic acid recognition by certain C-type lectins (the selectins), I-type lectins (e.g., CD22 and sialoadhesin), and a complement regulatory protein (the H protein).	N-Acetylneuraminic Acid	75-86	sialic acid binding Ig like lectin 1	Homo sapiens	173-185
9089440-2	1997	A potential role for sialic acid in the voltage-dependent gating of rat skeletal muscle sodium channels (rSkM1) was investigated using Chinese hamster ovary (CHO) cells stably transfected with rSkM1.	N-Acetylneuraminic Acid	21-32	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	105-110
9089440-3	1997	Changes in the voltage dependence of channel gating were observed after enzymatic (neuraminidase) removal of sialic acid from cells expressing rSkM1 and through the expression of rSkM1 in a sialylation-deficient cell line (lec2).	N-Acetylneuraminic Acid	109-120	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	143-148
9089440-9	1997	These results are consistent with an electrostatic mechanism by which external, negatively charged sialic acid residues on rSkM1 alter the electric field sensed by channel gating elements.	N-Acetylneuraminic Acid	99-110	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	123-128
9070454-0	1997	Expression, crystallization, and preliminary X-ray analysis of a sialic acid-binding fragment of sialoadhesin in the presence and absence of ligand.	N-Acetylneuraminic Acid	65-76	sialic acid binding Ig like lectin 1	Homo sapiens	97-109
8995428-10	1997	The simplest ganglioside ligand for MAG was GM3 bearing N-acetylneuraminic acid, whereas GM3 bearing N-glycolylneuraminic acid did not support adhesion.	N-Acetylneuraminic Acid	56-79	LOC103161439	Cricetulus griseus	36-39
8995428-11	1997	Chemical modifications of N-acetylneuraminic acid residues (on GD1a) abrogated MAG binding.	N-Acetylneuraminic Acid	26-49	LOC103161439	Cricetulus griseus	79-82
8899146-0	1996	Plasma fibrinogen and its relationship to plasma sialic acid in non-insulin-dependent diabetes mellitus.	N-Acetylneuraminic Acid	49-60	fibrinogen beta chain	Homo sapiens	7-17
9041521-3	1997	After treatment with bacterial neuraminidase, the metacyclic forms (G strain) remained reactive with the monoclonal antibody (mAb) 10D8 but lost their reactivity with mAb 3C9, that recognizes sialic acid-containing epitopes on gp35/50, and entered HeLa cells in significantly higher numbers as compared to untreated controls.	N-Acetylneuraminic Acid	192-203	neuraminidase 1	Homo sapiens	31-44
9041521-4	1997	Resialylation of gp35/50, by incubation of parasites with T. cruzi trans-sialidase and sialyl lactose, restored the reactivity with mAb 3C9 as well as the affinity for sialic acid specific lectin.	N-Acetylneuraminic Acid	168-179	tumor associated calcium signal transducer 2	Homo sapiens	17-24
9041521-8	1997	Consistent with the results of cell invasion assay, the desialylated parasite preparations, as well as the sialic acid free gp35/50, induced an average elevation in [Ca2+]i significantly higher than that triggered by untreated controls.	N-Acetylneuraminic Acid	107-118	tumor associated calcium signal transducer 2	Homo sapiens	124-131
9183857-5	1997	The study of sample-matrix solution composition, pH and instrumental conditions allow the molecular weight determination of highly glycosylated proteins with a high percentage of sialic acid, e.g. erythropoietin.	N-Acetylneuraminic Acid	179-190	erythropoietin	Homo sapiens	197-211
8981082-3	1996	More recently, the Sialoadhesin family of sialic acid-dependent adhesion molecules was defined within the superfamily of immunoglobulin-like molecules.	N-Acetylneuraminic Acid	42-53	sialic acid binding Ig like lectin 1	Homo sapiens	19-31
8981088-0	1996	A sialic acid-binding lectin from ovine placenta: purification, specificity and interaction with actin.	N-Acetylneuraminic Acid	2-13	actin	Oryctolagus cuniculus	97-102
8981093-2	1996	The mean pI values of the EPO fractions determined by IEF-gel electrophoresis systematically shifted from 4.11 to 3.31, coinciding with the sialic acid content, without a change in the constitution of asialo N-linked oligosaccharides of each fraction.	N-Acetylneuraminic Acid	140-151	erythropoietin	Homo sapiens	26-29
8981093-3	1996	Although a linear relationship between the in vivo bioactivity and the sialic acid content of the fractionated samples was observed until 12.1 mol mol-1 of EPO, there was no further increase in their activity over 12.4 mol mol-1 of EPO.	N-Acetylneuraminic Acid	71-82	erythropoietin	Homo sapiens	156-159
8981093-4	1996	On the other hand, an inverse relationship between the in vitro bioactivity and sialic acid content of EPO was observed.	N-Acetylneuraminic Acid	80-91	erythropoietin	Homo sapiens	103-106
8998824-1	1996	BACKGROUND: Sialic acid is released from terminal oligosaccharide chain of some proteins of the acute phase (fibrinogen, orosomucoid, haptoglobin, etc.).	N-Acetylneuraminic Acid	12-23	haptoglobin	Homo sapiens	134-145
8955503-5	1996	We also found that both lipoteichoic acid and sialic acid stimulated concentration-dependent increases in chorion cell IL-8 production.	N-Acetylneuraminic Acid	46-57	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
8895720-1	1996	It has been shown that high sialic acid levels are often found in conjunction with breast cancer, and these high concentrations are thought to be due to deficiency of the enzyme neuraminidase.	N-Acetylneuraminic Acid	28-39	neuraminidase 1	Homo sapiens	178-191
8918571-11	1996	Our study shows that the state of glycosylation of IgG affects the t1/2 in vivo, and that by removing the terminal sugars (sialic acid and galactose), the antibody (IgG2a) will remain in circulation significantly longer.	N-Acetylneuraminic Acid	123-134	immunoglobulin heavy variable V1-9	Mus musculus	165-170
9091428-2	1996	It is also known that estrogens increase the hepatic production of SHBG which circulates in various molecular forms containing different amounts of sialic acid as the main component of carbohydrates.	N-Acetylneuraminic Acid	148-159	sex hormone binding globulin	Homo sapiens	67-71
9091428-9	1996	It is concluded that SHBG concentrations varies during the menstrual cycle according the estrogen levels which in addition regulates the proportion of molecular forms and sialic acid containt.	N-Acetylneuraminic Acid	171-182	sex hormone binding globulin	Homo sapiens	21-25
9143697-5	1997	CD22 is a member of the Ig superfamily that serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes.	N-Acetylneuraminic Acid	79-90	CD22 antigen	Mus musculus	0-4
9562656-0	1997	Relationship between serum total sialic acid and C-reactive protein in silicosis.	N-Acetylneuraminic Acid	33-44	C-reactive protein	Homo sapiens	49-67
9562656-3	1997	The changes in serum total sialic acid levels were in parallel with those of CRP in silicosis.	N-Acetylneuraminic Acid	27-38	C-reactive protein	Homo sapiens	77-80
9562656-5	1997	Linear regression analysis revealed a close positive correlation between serum total sialic acid and CRP levels in silicosis (r = 0.86, p &lt; 0.01).	N-Acetylneuraminic Acid	85-96	C-reactive protein	Homo sapiens	101-104
9027351-10	1996	The clearance of hLH and hFSH showed a bi-exponential pattern for all isoform preparations with the proportion of the slower dissociating component (t 1/2 50-60 min) increasing three-fold with increasing sialic acid content of the isoform.	N-Acetylneuraminic Acid	204-215	interleukin 1 receptor like 1	Homo sapiens	149-160
11667846-0	1996	Synthesis of C-5 Analogs of N-Acetylneuraminic Acid via Indium-Mediated Allylation of N-Substituted 2-Amino-2-deoxymannoses.	N-Acetylneuraminic Acid	28-51	complement C5	Homo sapiens	13-16
11667846-1	1996	This paper presents a short synthesis of new analogs of N-acetylneuraminic acid (Neu5Ac) varied structurally at C-5.	N-Acetylneuraminic Acid	56-79	complement C5	Homo sapiens	112-115
11667846-1	1996	This paper presents a short synthesis of new analogs of N-acetylneuraminic acid (Neu5Ac) varied structurally at C-5.	N-Acetylneuraminic Acid	81-87	complement C5	Homo sapiens	112-115
9219441-3	1996	Levels of protein bound hexose, fucose and sialic acid which were increased during leukaemia attained normal levels when treated with L-asparaginase.	N-Acetylneuraminic Acid	43-54	asparaginase like 1	Mus musculus	134-148
9110350-6	1996	Neuraminidase treatment revealed that SBA lectin binding sites were masked by sialic acid.	N-Acetylneuraminic Acid	78-89	neuraminidase 1	Homo sapiens	0-13
9110350-6	1996	Neuraminidase treatment revealed that SBA lectin binding sites were masked by sialic acid.	N-Acetylneuraminic Acid	78-89	LOW QUALITY PROTEIN: lectin	Glycine max	42-48
8972015-5	1996	We conclude that decreased erythrocyte sialic acid content may intensify the effect of fibrinogen on aggregation and disaggregation of erythrocytes and participate in the development of atherothrombotic complications.	N-Acetylneuraminic Acid	39-50	fibrinogen beta chain	Homo sapiens	87-97
8979368-6	1996	The lamins and p55 demonstrated a greater N-acetylglucosamine/sialic acid content and p55 an increased in vitro phosphorylation by a nuclear matrix-associated cyclic-nucleotide-independent kinase.	N-Acetylneuraminic Acid	62-73	MAGUK p55 scaffold protein 1	Rattus norvegicus	15-18
8899146-2	1996	We postulated that plasma SA may be related to plasma fibrinogen, another reputed cardiovascular risk factor.	N-Acetylneuraminic Acid	26-28	fibrinogen beta chain	Homo sapiens	54-64
8805371-7	1996	Our results also show that PST-1 can act on core structures with the terminal sialic acid connected to galactose via an alpha2,3 or alpha2,6 linkage.	N-Acetylneuraminic Acid	78-89	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	27-32
8899146-6	1996	There was a strong univariate correlation between plasma fibrinogen and plasma SA in both NIDDM patients (r = 0.80, P &lt; 0.001) and control subjects (r = 0.54, P &lt; 0.01).	N-Acetylneuraminic Acid	79-81	fibrinogen beta chain	Homo sapiens	57-67
8702582-6	1996	The data suggest that sialic acid addition modifies Kv1.1 channel function, possibly by influencing the local electric field detected by its voltage sensor, but that these carbohydrates are not required for cell surface expression.	N-Acetylneuraminic Acid	22-33	potassium voltage-gated channel subfamily A member 1	Rattus norvegicus	52-57
8759764-5	1996	These observations led us to conclude that bovine DBP carries a trisaccharide composed of N-acetylgalactosamine, galactose, and sialic acid, whereas mouse DBP carries a disaccharide composed of N-acetylgalactosamine and galactose.	N-Acetylneuraminic Acid	128-139	D-box binding PAR bZIP transcription factor	Bos taurus	50-53
9239678-3	1996	Removal of sperm surface sialic acid by neuraminidase treatment was a prerequisite for Con A and PNA binding to the sperm surface.	N-Acetylneuraminic Acid	25-36	neuraminidase 1	Homo sapiens	40-53
8702538-2	1996	Recent work has shown that CD22 specifically recognizes sialic acid linked alpha2,6 to terminal N-linked oligosaccharides on selected cell surface glycoproteins.	N-Acetylneuraminic Acid	56-67	CD22 molecule	Homo sapiens	27-31
8702538-9	1996	In contrast, mutation of a NCS motif in the first Ig domain of the I-type lectin CD33 unmasked its sialic acid binding activity.	N-Acetylneuraminic Acid	99-110	CD33 molecule	Homo sapiens	81-85
8770047-0	1996	HCO3(-)-dependent conformational change in gastric parietal cell AE2, a glycoprotein naturally lacking sialic acid.	N-Acetylneuraminic Acid	103-114	solute carrier family 4 member 2	Sus scrofa	65-68
8707864-7	1996	Removal of the sialic acid component of the carbohydrate from wild-type TfR by treatment of live cells with neuraminidase enhances TfR cleavage.	N-Acetylneuraminic Acid	15-26	transferrin receptor	Homo sapiens	72-75
8879537-1	1996	A practical synthesis of the sialyl Lewis X (sLex) pentasaccharide, NeuAc alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-3Gal beta OEt (1), as a potential blocker for E-selectin has been described.	N-Acetylneuraminic Acid	68-73	selectin E	Homo sapiens	170-180
8757818-5	1996	Chemical analysis of the LPS revealed that the core oligosaccharide has a terminal trisaccharide epitope consisting of two molecules of sialic acid linked to galactose, a structure reflecting the terminal region of human ganglioside GD3.	N-Acetylneuraminic Acid	136-147	GRDX	Homo sapiens	233-236
8707864-7	1996	Removal of the sialic acid component of the carbohydrate from wild-type TfR by treatment of live cells with neuraminidase enhances TfR cleavage.	N-Acetylneuraminic Acid	15-26	neuraminidase 1	Homo sapiens	108-121
8707864-7	1996	Removal of the sialic acid component of the carbohydrate from wild-type TfR by treatment of live cells with neuraminidase enhances TfR cleavage.	N-Acetylneuraminic Acid	15-26	transferrin receptor	Homo sapiens	131-134
8707864-9	1996	Treatment of IdlD cells with neuraminidase reveals that the sialic acid of the O-linked carbohydrate protects against TfR cleavage, whereas the core sugars Gal-NAc and Gal do not protect as much.	N-Acetylneuraminic Acid	60-71	neuraminidase 1	Homo sapiens	29-42
8707864-9	1996	Treatment of IdlD cells with neuraminidase reveals that the sialic acid of the O-linked carbohydrate protects against TfR cleavage, whereas the core sugars Gal-NAc and Gal do not protect as much.	N-Acetylneuraminic Acid	60-71	transferrin receptor	Homo sapiens	118-121
8864946-4	1996	Fractional catabolic rate (FCR) for LDL apoB was significantly faster in the diabetics than in the non-diabetics, and was positively associated with the sialic acid ratio in the total and dense LDL.	N-Acetylneuraminic Acid	153-164	apolipoprotein B	Homo sapiens	40-44
8889826-6	1996	However, elimination of peripheral sialic acid and galactose residues by sequential treatment with neuraminidase and beta-galactosidase gave clear mass spectra with several sharp peaks.	N-Acetylneuraminic Acid	35-46	neuraminidase 1	Homo sapiens	99-112
8889826-6	1996	However, elimination of peripheral sialic acid and galactose residues by sequential treatment with neuraminidase and beta-galactosidase gave clear mass spectra with several sharp peaks.	N-Acetylneuraminic Acid	35-46	galactosidase beta 1	Homo sapiens	117-135
8755731-4	1996	Treatment of reassembled glycophorin-liposomes with neuraminidase resulted in a significant decrease in the percent of viral fusion, confirming that the presence of sialic acid residues on glycophorin is essential for its role as a receptor.	N-Acetylneuraminic Acid	165-176	neuraminidase 1	Homo sapiens	52-65
8864946-7	1996	These results suggest that in this population the sialic acid content of LDL was not associated with clinical signs of atherosclerosis, but the catabolic rate of dense LDL apoB was positively related to the sialic acid content of the respective lipoproteins.	N-Acetylneuraminic Acid	207-218	apolipoprotein B	Homo sapiens	172-176
8873048-4	1996	Furthermore, immunoblots on neuraminidase-treated cell lysates show, in agreement with already published data, that the antigen might be a sialated glycoprotein with the sialic acid involved in the epitope.	N-Acetylneuraminic Acid	170-181	neuraminidase 1	Homo sapiens	28-41
8755516-3	1996	Chinese hamster ovary (CHO) mutants of the complementation group Lec2 exhibit a strong reduction in sialylation of glycoproteins and glycolipids due to a defect in the CMP-sialic acid transport system.	N-Acetylneuraminic Acid	172-183	adhesion G protein-coupled receptor L1	Mus musculus	65-69
8760858-8	1996	Further ultrastructural evaluation, using peroxidase labeled LFA lectin, revealed sialic acid moieties in patches on the CAM endothelium.	N-Acetylneuraminic Acid	82-93	calmodulin 2	Gallus gallus	121-124
8760858-9	1996	Thus, in early chick embryogenesis, the CAM endothelium displays a continuous pattern of luminal anionic sites comprised in part of sialic acid.	N-Acetylneuraminic Acid	132-143	calmodulin 2	Gallus gallus	40-43
8755516-4	1996	By complementation cloning in the mutant 6B2, belonging to the Lec2 complementation group, we were able to isolate a cDNA encoding the putative murine Golgi CMP-sialic acid transporter.	N-Acetylneuraminic Acid	161-172	adhesion G protein-coupled receptor L1	Mus musculus	63-67
8842677-12	1996	While the removal of sialic acid causes only partial loss in mucin aggregating capacity, a complete loss in the bacterial aggregating activity occurs following mucin desulfation.	N-Acetylneuraminic Acid	21-32	LOC100508689	Homo sapiens	61-66
8832102-1	1996	Trypanosoma cruzi, the agent of Chagas" disease, presents an enzyme that catalyzes the transfer of sialic acid among glycoproteins and glycolipids known as trans-sialidase (TS), displaying some interesting features: 1) It differs from all other eucaryotic sialyltransferases, both kinetically and in substrate specificity and 2) it is involved in the parasite"s mechanism of mammalian host cell invasion.	N-Acetylneuraminic Acid	99-110	RT1 class Ib, locus EC2	Rattus norvegicus	173-175
8663114-2	1996	NeuAc is known to be biosynthesized either from UDP-N-acetyl-D-glucosamine by an action of UDP-N-acetyl-D-glucosamine 2-epimerase or from N-acetyl-D-glucosamine by N-acyl-D-glucosamine 2-epimerase (GlcNAc 2-epimerase).	N-Acetylneuraminic Acid	0-5	renin binding protein	Sus scrofa	198-216
8663114-3	1996	However, the physiological function of the GlcNAc 2-epimerase in NeuAc biosynthesis has not been fully evaluated.	N-Acetylneuraminic Acid	65-70	renin binding protein	Sus scrofa	43-61
8663114-4	1996	To clarify the role of GlcNAc 2-epimerase in NeuAc biosynthesis, the enzyme and its gene were isolated from porcine kidney cortex.	N-Acetylneuraminic Acid	45-50	renin binding protein	Sus scrofa	23-41
8616412-11	1996	C Reactive protein concentration was associated with raised serum fibrinogen, sialic acid, total cholesterol, triglyceride, glucose, and apolipoprotein B values.	N-Acetylneuraminic Acid	78-89	C-reactive protein	Homo sapiens	0-18
8652824-12	1996	On desialylated JOK-1 cells, ecto-ST in the presence of exogenous CMP-NeuAc was able to resialylate the B-cell surface sialoglycans CDw75 and HB-6 and major surface glycoproteins of B cells, such as HLA class I and II antigens, transferrin receptor, and surface IgM.	N-Acetylneuraminic Acid	70-75	transferrin receptor	Homo sapiens	228-248
8811430-5	1996	In this study, N-acetylneuramic acid, which belongs to the sialic acid family and is present in immunoglobulin G (IgG) epitopes, is used as an active ligand.	N-Acetylneuraminic Acid	15-36	immunoglobulin heavy variable V1-62	Mus musculus	96-118
8811430-5	1996	In this study, N-acetylneuramic acid, which belongs to the sialic acid family and is present in immunoglobulin G (IgG) epitopes, is used as an active ligand.	N-Acetylneuraminic Acid	59-70	immunoglobulin heavy variable V1-62	Mus musculus	96-118
8687384-2	1996	This study clarified an earlier discrepancy in the literature and confirmed that the major complex N-linked glycans on Bowes t-PA that carry sialic acid as their sole charged group are bi-antennary, core fucosylated, with terminal N-acetylgalactosamine residues.	N-Acetylneuraminic Acid	141-152	chromosome 20 open reading frame 181	Homo sapiens	125-129
8639842-1	1996	The B-lymphocyte-restricted adhesion protein CD22 mediates sialic acid-dependent cell-cell interactions.	N-Acetylneuraminic Acid	59-70	CD22 molecule	Homo sapiens	45-49
8793806-8	1996	The heat-intolerant IgA1 had lower amounts of sialic acid (27.4 micrograms/mg IgA1) than the tolerant IgA1 (37.6 micrograms/mg IgA1).	N-Acetylneuraminic Acid	46-57	immunoglobulin heavy constant alpha 1	Homo sapiens	20-24
8793806-8	1996	The heat-intolerant IgA1 had lower amounts of sialic acid (27.4 micrograms/mg IgA1) than the tolerant IgA1 (37.6 micrograms/mg IgA1).	N-Acetylneuraminic Acid	46-57	immunoglobulin heavy constant alpha 1	Homo sapiens	78-82
8793806-8	1996	The heat-intolerant IgA1 had lower amounts of sialic acid (27.4 micrograms/mg IgA1) than the tolerant IgA1 (37.6 micrograms/mg IgA1).	N-Acetylneuraminic Acid	46-57	immunoglobulin heavy constant alpha 1	Homo sapiens	78-82
8793806-8	1996	The heat-intolerant IgA1 had lower amounts of sialic acid (27.4 micrograms/mg IgA1) than the tolerant IgA1 (37.6 micrograms/mg IgA1).	N-Acetylneuraminic Acid	46-57	immunoglobulin heavy constant alpha 1	Homo sapiens	78-82
8631864-11	1996	The recombinant GM2A protein was purified to an electrophoretically homogeneous form and was found to stimulate the hydrolysis of NeuAc from GM2 by clostridial sialidase, but not the hydrolysis of GalNAc from GM2 by beta-hexosaminidase A.	N-Acetylneuraminic Acid	130-135	ganglioside GM2 activator	Homo sapiens	16-20
8631864-12	1996	Like GM2 activator protein, GM2A protein also specifically recognized the terminal GM2 epitope in GalNAc-GD1a and stimulated the hydrolysis of only the external NeuAc from this ganglioside by clostridial sialidase.	N-Acetylneuraminic Acid	161-166	ganglioside GM2 activator	Homo sapiens	28-32
8631864-14	1996	The presence of GM2A mRNA in human tissues and the selective stimulation of NeuAc hydrolysis by GM2A protein indicate that this activator protein may be involved in the catabolism of GM2 through the asialo-GM2 pathway.	N-Acetylneuraminic Acid	76-81	ganglioside GM2 activator	Homo sapiens	96-100
8732705-10	1996	Baseline serum sialic acid concentration correlated significantly with HbA1c, UAER, blood pressure, total cholesterol, HDL cholesterol, and vWF and was significantly predictive for development of microalbuminuria (hazards ratio [95% CI], 3.1 [1.2-8.1]; P = 0.02) after adjustments for sex, duration of diabetes, smoking, blood pressure, vWF, total cholesterol, and HDL cholesterol.	N-Acetylneuraminic Acid	15-26	von Willebrand factor	Homo sapiens	140-143
8732705-10	1996	Baseline serum sialic acid concentration correlated significantly with HbA1c, UAER, blood pressure, total cholesterol, HDL cholesterol, and vWF and was significantly predictive for development of microalbuminuria (hazards ratio [95% CI], 3.1 [1.2-8.1]; P = 0.02) after adjustments for sex, duration of diabetes, smoking, blood pressure, vWF, total cholesterol, and HDL cholesterol.	N-Acetylneuraminic Acid	15-26	von Willebrand factor	Homo sapiens	337-340
8732705-13	1996	An increased serum sialic acid concentration is predictive for the onset of microalbuminuria independent of age, sex, diabetes duration, smoking, blood pressure, vWF, and total HDL cholesterol.	N-Acetylneuraminic Acid	19-30	von Willebrand factor	Homo sapiens	162-165
8647179-8	1996	Furthermore, the sialic acid modifications of the F4/80 molecule are primarily through alpha 2-6 linkages to galactose.	N-Acetylneuraminic Acid	17-28	adhesion G protein-coupled receptor E1	Mus musculus	50-55
8647179-8	1996	Furthermore, the sialic acid modifications of the F4/80 molecule are primarily through alpha 2-6 linkages to galactose.	N-Acetylneuraminic Acid	17-28	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	87-96
8611500-8	1996	Characterization of the catalytic reaction products of SAT-3 and SAT-4 with thin-layer chromatography, sialidase treatment, and binding to specific antibodies indicates that both SAT-3 and SAT-4 catalyze the formation of alpha 2-3 linkage between sialic acid and terminal galactose of glycolipid substrates.	N-Acetylneuraminic Acid	247-258	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	55-60
8611500-8	1996	Characterization of the catalytic reaction products of SAT-3 and SAT-4 with thin-layer chromatography, sialidase treatment, and binding to specific antibodies indicates that both SAT-3 and SAT-4 catalyze the formation of alpha 2-3 linkage between sialic acid and terminal galactose of glycolipid substrates.	N-Acetylneuraminic Acid	247-258	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	179-184
8621588-0	1996	Localization of the putative sialic acid-binding site on the immunoglobulin superfamily cell-surface molecule CD22.	N-Acetylneuraminic Acid	29-40	CD22 antigen	Mus musculus	110-114
8621588-1	1996	B-lymphocyte antigen CD22 is a member of the recently described sialoadhesin family of immunoglobulin-like cell-surface glycoproteins that bind glycoconjugates terminating in sialic acid.	N-Acetylneuraminic Acid	175-186	CD22 antigen	Mus musculus	21-25
8621587-0	1996	Characterization of the sialic acid-binding site in sialoadhesin by site-directed mutagenesis.	N-Acetylneuraminic Acid	24-35	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	52-64
8621587-3	1996	Sialoadhesin is a murine macrophage-restricted cell-surface molecule with 17 extracellular immunoglobulin-like domains that recognizes NeuAc alpha 2-3Gal in N- and O-glycans and interacts preferentially with cells of the granulocytic lineage.	N-Acetylneuraminic Acid	135-140	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	0-12
8621587-9	1996	This amino acid is conserved among all members of the sialoadhesin family and is therefore likely to be a key residue in mediating sialic acid-dependent binding of sialoadhesins to cells.	N-Acetylneuraminic Acid	131-142	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	54-66
8621588-1	1996	B-lymphocyte antigen CD22 is a member of the recently described sialoadhesin family of immunoglobulin-like cell-surface glycoproteins that bind glycoconjugates terminating in sialic acid.	N-Acetylneuraminic Acid	175-186	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	64-76
8608564-3	1996	These two substrates were incubated with extracts from colorectal tissues in the presence of cytidine 5"-monophospho-N-acetylneuraminic acid (CMP-NeuAc) and their resulting products were detected by a sequential use of anti-BSA monoclonal antibody-coated beads and 125I-labelled anti-sialylated Le(c) antibody.	N-Acetylneuraminic Acid	146-151	C-C motif chemokine ligand 16	Homo sapiens	295-300
8621588-5	1996	Previous studies have shown that the sialic acid-binding site lies within the two membrane-distal domains of CD22 (domains 1 and 2), which are V-set and C2-set immunoglobulin superfamily domains, respectively.	N-Acetylneuraminic Acid	37-48	CD22 antigen	Mus musculus	109-113
8807196-1	1996	Differential splicing of VASE exon in the fourth immunoglobulin (Ig) domain and attachment to the fifth Ig domain of alpha 2-8 linked sialic acid (PSA) both dramatically change, in opposite manner, Neural Cell Adhesion Molecule (NCAM) functional properties.	N-Acetylneuraminic Acid	134-145	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	117-126
8605672-3	1996	Sialic acid-deficient transferrin fractions are collected in the eluate, and transferrin is then quantified by a rate-nephelometric technique.	N-Acetylneuraminic Acid	0-11	transferrin	Homo sapiens	22-33
8807196-1	1996	Differential splicing of VASE exon in the fourth immunoglobulin (Ig) domain and attachment to the fifth Ig domain of alpha 2-8 linked sialic acid (PSA) both dramatically change, in opposite manner, Neural Cell Adhesion Molecule (NCAM) functional properties.	N-Acetylneuraminic Acid	134-145	neural cell adhesion molecule 1	Mus musculus	198-227
8807196-1	1996	Differential splicing of VASE exon in the fourth immunoglobulin (Ig) domain and attachment to the fifth Ig domain of alpha 2-8 linked sialic acid (PSA) both dramatically change, in opposite manner, Neural Cell Adhesion Molecule (NCAM) functional properties.	N-Acetylneuraminic Acid	134-145	neural cell adhesion molecule 1	Mus musculus	229-233
8631818-7	1996	These results suggest that the alpha2,6-sialyltransferase disulfide-bonded dimer lacks catalytic activity due to a weak affinity for its sugar nucleotide donor, CMP-NeuAc, and that this catalytically inactive form of the enzyme may act as a galactose-specific lectin in the Golgi.	N-Acetylneuraminic Acid	165-170	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Bos taurus	31-57
8606123-4	1996	In an overlay assay, binding appears to be mediated by outer membrane proteins P2 and P5 of bacteria and sialic acid-containing oligosaccharides of mucin.	N-Acetylneuraminic Acid	105-116	LOC100508689	Homo sapiens	148-153
8631773-7	1996	The disialylated tetrasaccharide formed by reacting the sialyltransferase with the aforementioned sialoside was analyzed by one- and two-dimensional 1H and 13C NMR spectroscopy and was shown to be the Neu5Ac-alpha2,3Gal-beta1,3(Neu5Ac-alpha2,6)GalNAc sialoside.	N-Acetylneuraminic Acid	201-207	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	220-227
8625917-7	1996	Analyses for sulfate and sialic acid contents demonstrated that pituitary hCG contained both sulfate and sialic acid.	N-Acetylneuraminic Acid	25-36	chorionic gonadotropin subunit beta 5	Homo sapiens	74-77
8625917-7	1996	Analyses for sulfate and sialic acid contents demonstrated that pituitary hCG contained both sulfate and sialic acid.	N-Acetylneuraminic Acid	105-116	chorionic gonadotropin subunit beta 5	Homo sapiens	74-77
8621395-6	1996	Completeness of modification of sialic acid by mild periodate was verified with monoclonal antibody to sialyl Lewisx-related structures and resistance to neuraminidase.	N-Acetylneuraminic Acid	32-43	neuraminidase 1	Homo sapiens	154-167
8833093-0	1996	The myelin-associated glycoprotein of the peripheral nervous system in trembler mutants contains increased alpha 2-3 sialic acid and galactose.	N-Acetylneuraminic Acid	117-128	myelin-associated glycoprotein	Mus musculus	4-34
8631269-10	1996	The anti-adhesive quality of the mucin resides in the sialic acid residues of the carbohydrate side chains.	N-Acetylneuraminic Acid	54-65	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	33-38
8833093-7	1996	Lectin binding and glycosidase treatments demonstrated that the higher molecular weight of MAG in trembler nerves was due to an increased content of alpha 2-3 linked sialic acid and galactose.	N-Acetylneuraminic Acid	166-177	myelin-associated glycoprotein	Mus musculus	91-94
8807834-5	1996	RESULTS: Polyacrylamides with multiple C-sialosides (PA(Neu5Ac)) were 2-20 fold more effective as inhibitors of virally mediated hemagglutination when assayed in the presence of Neu2en-NH2, a potent monomeric inhibitor of influenza neuraminidase (NA).	N-Acetylneuraminic Acid	56-62	neuraminidase 1	Homo sapiens	232-245
8617281-5	1996	Structural chemistry of MUC1 oligosaccharides demonstrated that the cancer-associated glycoforms carry mainly sialylated trisaccharides NeuAc alpha 2-3Gal Beta 1-3GalNAc or NeuAc alpha 2-6(Gal beta l-3)GalNAc, exhibit a concomitant decrease in the ratio of GlcNAc/GalNAc, a reduction or disappearance of L-fucose, and a partial substitution of N-acetylneuraminic acid by the N-glycolylated variant.	N-Acetylneuraminic Acid	344-367	mucin 1, cell surface associated	Homo sapiens	24-28
8631981-6	1996	GD3/GT3ST synthesized GT3 most efficiently when GM3, NeuNAcalpha2--&gt;3Galbeta1--&gt;4Glc--&gt;Cer, was incubated as an acceptor, indicating that GD3/GT3ST is a polysialyltransferase that can transfer more than one sialic acid residue via alpha-2,8 linkage to gangliosides.	N-Acetylneuraminic Acid	216-227	GRDX	Homo sapiens	0-3
8631981-6	1996	GD3/GT3ST synthesized GT3 most efficiently when GM3, NeuNAcalpha2--&gt;3Galbeta1--&gt;4Glc--&gt;Cer, was incubated as an acceptor, indicating that GD3/GT3ST is a polysialyltransferase that can transfer more than one sialic acid residue via alpha-2,8 linkage to gangliosides.	N-Acetylneuraminic Acid	216-227	GRDX	Homo sapiens	0-9
8617281-7	1996	During serum-free cultivation of T47D cells over 4 weeks, the expression of secretory MUC1 glycoforms was inconsistent based on the decreasing contents of sialic acid and on the concomitant increase of immunodetectable TF antigen.	N-Acetylneuraminic Acid	155-166	mucin 1, cell surface associated	Homo sapiens	86-90
8660295-5	1996	Our findings also indicated that the high content of apolipoprotein(a) in N-acetylneuraminic acid residues was only partly responsible for the resistance of Lp(a) to oxidation.	N-Acetylneuraminic Acid	74-97	lipoprotein(a)	Homo sapiens	157-162
8807834-5	1996	RESULTS: Polyacrylamides with multiple C-sialosides (PA(Neu5Ac)) were 2-20 fold more effective as inhibitors of virally mediated hemagglutination when assayed in the presence of Neu2en-NH2, a potent monomeric inhibitor of influenza neuraminidase (NA).	N-Acetylneuraminic Acid	56-62	neuraminidase 1	Homo sapiens	247-249
8807834-7	1996	CONCLUSIONS: We propose that inhibitors of NA act by competing with the C-sialosides of PA(Neu5Ac) for binding to the active sites of the NA.	N-Acetylneuraminic Acid	91-97	neuraminidase 1	Homo sapiens	43-45
8807834-7	1996	CONCLUSIONS: We propose that inhibitors of NA act by competing with the C-sialosides of PA(Neu5Ac) for binding to the active sites of the NA.	N-Acetylneuraminic Acid	91-97	neuraminidase 1	Homo sapiens	138-140
8731478-5	1996	Furthermore, MAG binds to neurons from which it promotes and from which it inhibits outgrowth, in a sialic-acid-dependent manner.	N-Acetylneuraminic Acid	100-111	myelin associated glycoprotein	Homo sapiens	13-16
8900954-2	1996	The cIEF method principally separates the charged glycoforms of recombinant tissue-type plasminogen activator (rt-PA) on the basis of their sialic acid content.	N-Acetylneuraminic Acid	140-151	plasminogen activator, tissue type	Homo sapiens	76-109
8627168-10	1996	In conclusion, VAP-1 naturally exists as a 170-kD sialoglycoprotein that uses sialic acid residues to interact with its counter-receptors on lymphocytes under nonstatic conditions.	N-Acetylneuraminic Acid	78-89	amine oxidase copper containing 3	Homo sapiens	15-20
8731478-8	1996	Binding of MAG to all the neurons tested here was also sialic-acid-dependent.	N-Acetylneuraminic Acid	55-66	myelin associated glycoprotein	Homo sapiens	11-14
8731478-9	1996	Importantly, both inhibition and promotion of neurite outgrowth by MAG are reduced, or abolished completely, either by desialyation of the neurons prior to the outgrowth assay or by including small sialic-acid-bearing sugars in the cultures.	N-Acetylneuraminic Acid	198-209	myelin associated glycoprotein	Homo sapiens	67-70
8544269-1	1996	OBJECTIVE: The current study evaluated whether intranasal administration of the sialic acid analog 4-guanidino-Neu5Ac2en (GG167), an inhibitor of influenza virus neuraminidase, was effective and safe in either preventing or treating experimental human influenza.	N-Acetylneuraminic Acid	80-91	neuraminidase 1	Homo sapiens	162-175
8631363-3	1996	Sugar composition analyses revealed that the tumor necrosis factor-alpha contained galactose, N-acetylgalactosamine and N-acetylneuraminic acid as sugar components.	N-Acetylneuraminic Acid	120-143	tumor necrosis factor	Homo sapiens	45-72
8567623-1	1996	Polysialic acid (PSA) is a linear homopolymer of alpha-2,8-linked sialic acid residues whose expression is developmentally regulated and modulates the adhesive property of the neural adhesion molecule, N-CAM.	N-Acetylneuraminic Acid	4-15	neural cell adhesion molecule 1	Homo sapiens	202-207
8567623-13	1996	These results establish that a single enzyme, PST, alone can catalyze both the addition of the first alpha-2,8-linked sialic acid to alpha-2,3-linked sialic acid and the polycondensation of all alpha-2,8-linked sialic acids, yielding PSA.	N-Acetylneuraminic Acid	118-129	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	46-49
8542600-4	1996	Introduction of the GnT-III gene resulted in an increase of bisecting GlcNAc and a decrease of external sialic acid as well as tri- and tetraantennary sugars, as judged by flow cytometry.	N-Acetylneuraminic Acid	104-115	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	20-27
8831948-6	1996	Carbohydrate analyses showed that the sialic acid content was higher in SP I (11.4% of dry tissue weight) than in the more prominent SP II (5.3%).	N-Acetylneuraminic Acid	38-49	chromogranin A	Bos taurus	72-76
8548845-1	1996	Monoclonal antibody CZ-1 defines a novel sialic acid-dependent CD45RB-associated epitope.	N-Acetylneuraminic Acid	41-52	immunoglobulin kappa variable 1-115	Mus musculus	20-24
8547663-5	1996	Among these binding proteins, sialic acid residues were contained in 67BP, L-selectin, and NCA90, but not in the 28-kD and 49-kD proteins.	N-Acetylneuraminic Acid	30-41	selectin L	Homo sapiens	75-85
8547663-7	1996	Thus, the sialic acid residues of 67BP, L-selectin, and NCA90 seem to be important for the binding of neutrophils to type IV collagen.	N-Acetylneuraminic Acid	10-21	selectin L	Homo sapiens	40-50
8777139-3	1996	We modified N-acetylneuraminic acid (NeuAc) on the oligosaccharide moieties of hCG, and determined the effect on its biological activity by measuring hormone-stimulated adenylyl cyclase.	N-Acetylneuraminic Acid	12-35	chorionic gonadotropin subunit beta 5	Homo sapiens	79-82
8777139-3	1996	We modified N-acetylneuraminic acid (NeuAc) on the oligosaccharide moieties of hCG, and determined the effect on its biological activity by measuring hormone-stimulated adenylyl cyclase.	N-Acetylneuraminic Acid	37-42	chorionic gonadotropin subunit beta 5	Homo sapiens	79-82
8777139-4	1996	Treating hCG with sodium periodate to remove two carbon atoms from NeuAc or quantitatively removing NeuAc from hCG reduced its biological activity by 36% and 50%, respectively.	N-Acetylneuraminic Acid	67-72	chorionic gonadotropin subunit beta 5	Homo sapiens	9-12
8777139-4	1996	Treating hCG with sodium periodate to remove two carbon atoms from NeuAc or quantitatively removing NeuAc from hCG reduced its biological activity by 36% and 50%, respectively.	N-Acetylneuraminic Acid	100-105	chorionic gonadotropin subunit beta 5	Homo sapiens	111-114
8777139-5	1996	The galactose residues of asialo-hCG were reacted with NeuAc-hydrazone or a hydrazone of the oligosaccharide from the ganglioside GM1 (Gal(beta 1-3)GalNAc(beta 1-4) [NeuAc(alpha 2-3)]Gal(beta 1-4)Glc).	N-Acetylneuraminic Acid	55-60	chorionic gonadotropin subunit beta 5	Homo sapiens	33-36
8777139-7	1996	These results suggest that several structural aspects of NeuAc including carbon side chain, an intact ring structure, and the position of NeuAc relative to other carbohydrate residues are important for full biological activity of hCG.	N-Acetylneuraminic Acid	57-62	chorionic gonadotropin subunit beta 5	Homo sapiens	230-233
8777139-7	1996	These results suggest that several structural aspects of NeuAc including carbon side chain, an intact ring structure, and the position of NeuAc relative to other carbohydrate residues are important for full biological activity of hCG.	N-Acetylneuraminic Acid	138-143	chorionic gonadotropin subunit beta 5	Homo sapiens	230-233
8543783-6	1996	In addition, gp300 showed complex changes during postnatal development in reactivity with the galactose binding lectin peanut agglutinin (PNA) and the sialic acid binding lectin Maackia amuresis (MAA).	N-Acetylneuraminic Acid	151-162	deleted in malignant brain tumors 1	Mus musculus	13-18
8557359-1	1996	Previously, we reported on the properties of a monoclonal antibody, 2B10, which has the same determinant on the human erythrocyte as MSA-1 of Plasmodium falciparum (FCR3 strain); the binding of both ligands to erythrocyte receptors was totally sialic acid dependent.	N-Acetylneuraminic Acid	244-255	coenzyme Q2, polyprenyltransferase	Homo sapiens	133-138
8730428-1	1996	Recombinant human erythropoietin (rHUEPO) was produced by Chinese hamster ovary cells and commercially distributed to hospitals by two pharmaceutical companies in Japan ("ESPO" by Kirin Brewery Co. Ltd., and Sankyo Co. Ltd., and "EPOGIN" by Chugai Pharmaceutical Co. Ltd.) These products contained about 1% N-glycolylneuraminic acid (Neu5Gc) in total sialic acid content.	N-Acetylneuraminic Acid	351-362	erythropoietin	Homo sapiens	18-32
8598452-9	1996	When N-terminal octapeptides from human glycophorin A that bore NeuAc alpha 2-3 Gal beta 1-3 (NeuAc alpha 2-6) GalNAc and its sequentially deglycosylated derivatives were compared, glycopeptides carrying three constitutive GalNAc-Ser/Thr (Tn Ag) strongly bound to the recombinant human macrophage lectin.	N-Acetylneuraminic Acid	64-69	glycophorin A (MNS blood group)	Homo sapiens	40-53
8598452-9	1996	When N-terminal octapeptides from human glycophorin A that bore NeuAc alpha 2-3 Gal beta 1-3 (NeuAc alpha 2-6) GalNAc and its sequentially deglycosylated derivatives were compared, glycopeptides carrying three constitutive GalNAc-Ser/Thr (Tn Ag) strongly bound to the recombinant human macrophage lectin.	N-Acetylneuraminic Acid	94-99	glycophorin A (MNS blood group)	Homo sapiens	40-53
8770386-3	1995	Addition of sialic acid and fucose catalyzed by alpha-2,3-sialyltransferase and alpha-1,3-fucosyltransferase provided the dimeric SLex, which was shown to be as active as monomeric SLex as an inhibitor of E-selectin with IC50 0.75 mM.	N-Acetylneuraminic Acid	12-23	fucosyltransferase 7	Homo sapiens	80-108
8547303-9	1995	The oligosaccharides carry substantial sialic acid at their termini and this accounts for two putative functions of this mucin, i.e., to keep ducts and lumens open by creating a strong negative charge on the surface of epithelial cells which would repel opposite sides of a vessel, and to bind certain pathogenic microorganisms.	N-Acetylneuraminic Acid	39-50	LOC100508689	Homo sapiens	121-126
8770386-3	1995	Addition of sialic acid and fucose catalyzed by alpha-2,3-sialyltransferase and alpha-1,3-fucosyltransferase provided the dimeric SLex, which was shown to be as active as monomeric SLex as an inhibitor of E-selectin with IC50 0.75 mM.	N-Acetylneuraminic Acid	12-23	selectin E	Homo sapiens	205-215
8748149-1	1995	We present kinetic studies on the enzymatic transfer of several synthetic sialic acid analogues, modified at C-5, to distinct glycoprotein glycans by sialyltransferases differing in acceptor- and linkage-specificity.	N-Acetylneuraminic Acid	74-85	complement C5	Rattus norvegicus	109-112
8750219-0	1995	The urinary concentration of sialic acid is increased in non-insulin-dependent diabetic patients with microangiopathy: a possible useful marker for diabetic microangiopathy.	N-Acetylneuraminic Acid	29-40	insulin	Homo sapiens	61-68
8822433-1	1995	A Ca(2+)-dependent sialic acid-binding protein (SABP) of human endometrium, which specifically bound to human sperm head plasma membrane in vitro, was found to increase the percentage motility and acrosome-reacted pattern of uncapacitated spermatozoa.	N-Acetylneuraminic Acid	19-30	prolactin induced protein	Homo sapiens	48-52
8530628-4	1995	More than half of the total serum TBG had reduced sialic acid content and localized on isoelectric focusing (IEF) as two prominent bands cathodal to the three major bands of normal TBG.	N-Acetylneuraminic Acid	50-61	serpin family A member 7	Homo sapiens	34-37
8770659-7	1995	In fact, the NCAM hand from ethanol-treated embryos at E8 migrated at a higher molecular weight than did its control counterpart, indicating an increase in sialic acid content.	N-Acetylneuraminic Acid	156-167	neural cell adhesion molecule 1	Gallus gallus	13-17
8556161-9	1995	Oligosaccharides released from neuraminidase treated rFVIIa elute earlier compared to oligosaccharides from native rFVIIa, but separated into several peaks, indicating heterogeneity for the oligosaccharide structures without N-acetyl-neuraminic acid.	N-Acetylneuraminic Acid	225-249	neuraminidase 1	Homo sapiens	31-44
7592823-0	1995	The amino-terminal immunoglobulin-like domain of sialoadhesin contains the sialic acid binding site.	N-Acetylneuraminic Acid	75-86	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	49-61
7592944-9	1995	Finally, it was shown that the sialic acid and O-linked oligosaccharides of glycophorin A did not play any role in its effect against NK cells.	N-Acetylneuraminic Acid	31-42	glycophorin A (MNS blood group)	Homo sapiens	76-89
7592823-2	1995	Sialoadhesin and CD22 are members of a recently characterized family of sialic acid-dependent adhesion molecules belonging to the immunoglobulin superfamily.	N-Acetylneuraminic Acid	72-83	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	0-12
7592823-2	1995	Sialoadhesin and CD22 are members of a recently characterized family of sialic acid-dependent adhesion molecules belonging to the immunoglobulin superfamily.	N-Acetylneuraminic Acid	72-83	CD22 antigen	Mus musculus	17-21
7592823-3	1995	Sialoadhesin is a macrophage-restricted receptor containing 17 extracellular Ig-like domains which recognizes oligosaccharides terminating in NeuAc alpha 2-3Gal in N- and O-linked glycans.	N-Acetylneuraminic Acid	142-147	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	0-12
7592823-8	1995	For sialoadhesin, the amino-terminal V-set Ig-like domain was both necessary and sufficient to mediate sialic acid-dependent adhesion of the correct specificity.	N-Acetylneuraminic Acid	103-114	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	4-16
7592823-9	1995	In contrast, for murine CD22, only constructs containing both the V-set domain and the adjacent C2-set domain were able to mediate sialic acid-dependent binding.	N-Acetylneuraminic Acid	131-142	CD22 antigen	Mus musculus	24-28
8593487-1	1995	Our previous study has shown that urinary bikunin has four major isomers, which differ with respect to the sulfation ratio in a glycosaminoglycan chain but which do not exhibit any differences in amino acid composition, N-terminal amino acid sequence, C-terminal amino acid, sialic acid and uronic acid content.	N-Acetylneuraminic Acid	275-286	alpha-1-microglobulin/bikunin precursor	Homo sapiens	42-49
8593259-2	1995	It has recently been proven to be a sialic acid-binding protein in vitro and in the case of mammalian tissues to bind specifically to annexin II, annexin VI, annexin XI, and glyceraldehyde-3-phosphate dehydrogenase in a Ca(2+)-dependent manner.	N-Acetylneuraminic Acid	36-47	annexin A2	Homo sapiens	134-144
8750891-15	1995	These results demonstrate that 5-HT2C receptors contain N-linked sugars and suggest that sialic acid residues associate with 5-HT2C receptors in the choroid plexus.	N-Acetylneuraminic Acid	89-100	5-hydroxytryptamine receptor 2C	Rattus norvegicus	31-37
8750891-15	1995	These results demonstrate that 5-HT2C receptors contain N-linked sugars and suggest that sialic acid residues associate with 5-HT2C receptors in the choroid plexus.	N-Acetylneuraminic Acid	89-100	5-hydroxytryptamine receptor 2C	Rattus norvegicus	125-131
8593259-2	1995	It has recently been proven to be a sialic acid-binding protein in vitro and in the case of mammalian tissues to bind specifically to annexin II, annexin VI, annexin XI, and glyceraldehyde-3-phosphate dehydrogenase in a Ca(2+)-dependent manner.	N-Acetylneuraminic Acid	36-47	annexin A11	Homo sapiens	158-168
8593259-2	1995	It has recently been proven to be a sialic acid-binding protein in vitro and in the case of mammalian tissues to bind specifically to annexin II, annexin VI, annexin XI, and glyceraldehyde-3-phosphate dehydrogenase in a Ca(2+)-dependent manner.	N-Acetylneuraminic Acid	36-47	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	174-214
8560404-5	1995	The Lp(a) level was positively correlated with that of C-reactive protein (r = 0.415, p &lt; 0.002), sialic acid (r = 0.426, p &lt; 0.002), and IL-6 (r = 0.298, p &lt; 0.05) in the hemodialysis patients, but not in the controls or non-dialysis uremic patients.	N-Acetylneuraminic Acid	101-112	lipoprotein(a)	Homo sapiens	4-9
8595256-6	1995	This study has identified a novel structure in fibromodulin, namely a cap containing a sulphated galactose adjacent to a non-reducing terminal N-acetyl-neuraminic acid.	N-Acetylneuraminic Acid	143-167	fibromodulin	Bos taurus	47-59
8576639-6	1995	The accumulated apoE lacks the sialic acid residues, indicating that this final stage of processing must occur in the trans-Golgi network or later.	N-Acetylneuraminic Acid	31-42	apolipoprotein E	Mus musculus	16-20
8552211-4	1995	Several glycoproteins in blood, including transferrin, alpha 1-antitrypsin, antithrombin and thyroxine-binding globulin, demonstrated abnormal isoforms suggesting a partial deficiency of mainly one or two sialic acid residues.	N-Acetylneuraminic Acid	205-216	serpin family A member 7	Homo sapiens	93-119
8580710-4	1995	MAG has also been included in a family of sialic acid binding proteins, providing a clue to the identity of the MAG receptor.	N-Acetylneuraminic Acid	42-53	myelin-associated glycoprotein	Mus musculus	0-3
8580710-4	1995	MAG has also been included in a family of sialic acid binding proteins, providing a clue to the identity of the MAG receptor.	N-Acetylneuraminic Acid	42-53	myelin-associated glycoprotein	Mus musculus	112-115
7588709-6	1995	The monosialylated oligosaccharides of beta-trace protein coexpressed with human ST6N were found to contain NeuAc in alpha 2,6- or alpha 2,3-linkage in the same ratio.	N-Acetylneuraminic Acid	108-113	prostaglandin D2 synthase	Homo sapiens	39-57
8560432-5	1995	Removal of sialic acid from purified plasma vWF induced significant changes in the reactivity of both lectins.	N-Acetylneuraminic Acid	11-22	von Willebrand factor	Homo sapiens	44-47
7545681-4	1995	Using peptide-specific antibodies, lectins, and recombinant L-selectin, we detected the following species of GlyCAM-1: unglycosylated (&lt; 28 kDa); modified with GalNAc only (28-33 kDa); modified with sialic acid, fucose, and sulfate but lacking L-selectin reactivity (40-50 kDa); and mature (L-selectin-reactive) ligand (50-60 kDa).	N-Acetylneuraminic Acid	202-213	glycosylation dependent cell adhesion molecule 1 (pseudogene)	Homo sapiens	109-117
8563483-13	1995	Basic hCG isoforms with lower sialic acid content extracted from hydatidiform moles were more potent in activating adenylate cyclase, and showed high bioactivity/immunoactivity (B/I) ratio in CHO cells expressing human TSH receptors.	N-Acetylneuraminic Acid	30-41	chorionic gonadotropin subunit beta 5	Homo sapiens	6-9
7559389-1	1995	Polysialic acid, or PSA, is a term used to refer to linear homopolymers of alpha(2,8)-sialic acid residues displayed at the surface of some mammalian cells.	N-Acetylneuraminic Acid	4-15	aminopeptidase puromycin sensitive	Homo sapiens	20-23
7559389-6	1995	While a murine STX fusion protein can catalyze the synthesis of a single alpha(2,8)-sialic acid linkage in vitro, the ability of STX to participate in PSA expression in vivo has not been demonstrated.	N-Acetylneuraminic Acid	84-95	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Mus musculus	15-18
7503419-7	1995	In conclusion, inappropriate isoelectric focusing conditions strongly affect iron load stability of isotransferrins (obviously via low pH within the gel), resulting in transferrin iron release and cofocusing of isotransferrins with different sialic acid or iron contents.	N-Acetylneuraminic Acid	242-253	transferrin	Homo sapiens	103-114
7558418-5	1995	Neuraminidase treatment enhanced antibody binding by 50%, suggesting partial masking of the PD41 epitope by sialic acid.	N-Acetylneuraminic Acid	108-119	neuraminidase 1	Bos taurus	0-13
7662987-6	1995	Enzymatic removal of sialic acid did not facilitate CD43 cleavage by neutrophil elastase, a feature that distinguishes the action of neutrophil elastase from other proteases.	N-Acetylneuraminic Acid	21-32	elastase, neutrophil expressed	Homo sapiens	133-152
7588709-6	1995	The monosialylated oligosaccharides of beta-trace protein coexpressed with human ST6N were found to contain NeuAc in alpha 2,6- or alpha 2,3-linkage in the same ratio.	N-Acetylneuraminic Acid	108-113	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	81-85
7496498-0	1995	Interaction mechanisms between insulin and N-acetylneuraminic acid in affinity chromatography.	N-Acetylneuraminic Acid	43-66	insulin	Homo sapiens	31-38
7665231-8	1995	Neuraminidase digestion converts P-95 to a broad 65-kDa immunoreactive band, indicating the presence of terminal sialic acid residues.	N-Acetylneuraminic Acid	113-124	neuraminidase 1	Homo sapiens	0-13
7665231-8	1995	Neuraminidase digestion converts P-95 to a broad 65-kDa immunoreactive band, indicating the presence of terminal sialic acid residues.	N-Acetylneuraminic Acid	113-124	nibrin	Homo sapiens	33-37
8528519-0	1995	Removal of sialic acid from the surface of human MCF-7 mammary cancer cells abolishes E-cadherin-dependent cell-cell adhesion in an aggregation assay.	N-Acetylneuraminic Acid	11-22	cadherin 1	Homo sapiens	86-96
8528519-3	1995	E-cadherin from MCF-7 cells was shown to contain sialic acid.	N-Acetylneuraminic Acid	49-60	cadherin 1	Homo sapiens	0-10
8528519-4	1995	Treatment with neuraminidase was shown to remove this sialic acid, as well as most of the sialic acid present at the cell surface.	N-Acetylneuraminic Acid	54-65	neuraminidase 1	Homo sapiens	15-28
8528519-4	1995	Treatment with neuraminidase was shown to remove this sialic acid, as well as most of the sialic acid present at the cell surface.	N-Acetylneuraminic Acid	90-101	neuraminidase 1	Homo sapiens	15-28
7639696-2	1995	The carbohydrate content of MG1 derived from palatal (PAL), submandibular (SM) and sublingual (SL) saliva was typical of mucins but showed heterogeneity, especially in the amount of sialic acid and sulphated sugar residues.	N-Acetylneuraminic Acid	182-193	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	28-31
7664874-11	1995	Therefore, the removal of sialic acid moieties from the single N-glycan of each monomer apparently affects surface presentation of distinct CIDNP-reactive amino acids of SAP.	N-Acetylneuraminic Acid	26-37	amyloid P component, serum	Homo sapiens	170-173
7664879-5	1995	On the contrary, the poor reactivity of THGP with ricin increased substantially after removal of sialic acid and completely precipitated the lectin added.	N-Acetylneuraminic Acid	97-108	uromodulin	Homo sapiens	40-44
7575776-5	1995	The fasting insulin level was also correlated with the levels of heparin cofactor II and sialic acid in men (P &lt; 0.05).	N-Acetylneuraminic Acid	89-100	insulin	Homo sapiens	12-19
7639696-8	1995	DGE analysis of a chemically and enzymically modified MG1 series, followed by ELISA and dot-blot detection using specific monoclonal antibodies, lectins and high-iron diamine staining, suggests that the high electrophoretic mobility of PAL-MG1 is mainly the result of a high sulphate content, whereas the SL subpopulations differ mainly in binding type and amount of sialic acid.	N-Acetylneuraminic Acid	367-378	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	54-57
8529600-7	1995	The calculated pI for the human red cell glucose transporter (Glut1) with one sialic acid residue was decreased from 8.8 to 8.5 by introducing pKa value spreading and became consistent with the experimental pI value of 8.4 +/- 0.05 at 15 degrees C determined in the presence of 6 M urea.	N-Acetylneuraminic Acid	78-89	solute carrier family 2 member 1	Homo sapiens	62-67
8530048-3	1995	These molecules establish a distinct family of sialic acid-dependent adhesion molecules, the sialoadhesin family.	N-Acetylneuraminic Acid	47-58	sialic acid binding Ig like lectin 1	Homo sapiens	93-105
7573152-1	1995	Infantile free sialic acid storage disease (ISSD), is an inherited metabolic disorder characterized by hyperexcretion of free sialic acid in the urine and by its storage in the lysosomes of different tissues.	N-Acetylneuraminic Acid	15-26	solute carrier family 17 member 5	Homo sapiens	44-48
7573152-1	1995	Infantile free sialic acid storage disease (ISSD), is an inherited metabolic disorder characterized by hyperexcretion of free sialic acid in the urine and by its storage in the lysosomes of different tissues.	N-Acetylneuraminic Acid	126-137	solute carrier family 17 member 5	Homo sapiens	44-48
7594871-0	1995	[CD22: a cell adhesion molecule that displays alpha 2-6-linked sialic acid-binding lectin activity].	N-Acetylneuraminic Acid	63-74	CD22 molecule	Homo sapiens	1-5
7626605-0	1995	Interleukin-3-associated expression of gangliosides in mouse myelogenous leukemia NFS60 cells introduced with interleukin-3 gene: expression of ganglioside GD1a and key involvement of CMP-NeuAc:lactosylceramide alpha 2--&gt;3-sialyltransferase in GD1a expression.	N-Acetylneuraminic Acid	188-193	interleukin 3	Mus musculus	0-13
7626605-0	1995	Interleukin-3-associated expression of gangliosides in mouse myelogenous leukemia NFS60 cells introduced with interleukin-3 gene: expression of ganglioside GD1a and key involvement of CMP-NeuAc:lactosylceramide alpha 2--&gt;3-sialyltransferase in GD1a expression.	N-Acetylneuraminic Acid	188-193	interleukin 3	Mus musculus	110-123
7664303-0	1995	Alkylation of N-acetylneuraminic acid at C-4.	N-Acetylneuraminic Acid	14-37	complement C4A (Rodgers blood group)	Homo sapiens	41-44
17180039-5	1995	Removal of terminal sialic acid groups by treatment of B and T cell lines with Vibrio cholerae neuraminidase (VCN) augmented sensitivity towards anti-APO-1 and human APO-1 ligand induced apoptosis.	N-Acetylneuraminic Acid	20-31	Fas cell surface death receptor	Homo sapiens	150-155
17180039-5	1995	Removal of terminal sialic acid groups by treatment of B and T cell lines with Vibrio cholerae neuraminidase (VCN) augmented sensitivity towards anti-APO-1 and human APO-1 ligand induced apoptosis.	N-Acetylneuraminic Acid	20-31	Fas cell surface death receptor	Homo sapiens	166-178
7540657-8	1995	Sialic acid-containing peptides eluted from EL4 lymphoma cells could (a) stabilize H-2 molecules on RMA-S cells and (b) sensitize them for GD2-specific CTL.	N-Acetylneuraminic Acid	0-11	epilepsy 4	Mus musculus	44-47
7616106-4	1995	Previous studies have demonstrated that Gc globulin binds to C5-derived peptides via sialic acid residues on this carbohydrate side chain.	N-Acetylneuraminic Acid	85-96	GC vitamin D binding protein	Homo sapiens	40-51
7652979-1	1995	Carbohydrate deficient transferrin (CDT) is an isoform of transferrin with a reduced carbohydrate content, especially the negatively charged sialic acid.	N-Acetylneuraminic Acid	141-152	transferrin	Homo sapiens	23-34
7562401-0	1995	[Participation of sialic acid residue in the fibrinogen-fibrin conversion by thrombin].	N-Acetylneuraminic Acid	18-29	coagulation factor II, thrombin	Bos taurus	77-85
7562401-1	1995	In order to estimate the effects of sialic acid residues in fibrinogen on the fibrinogen-fibrin conversion by bovine thrombin the Michaelis constant (Km) and maximum velocity (Vmax) were determined.	N-Acetylneuraminic Acid	36-47	coagulation factor II, thrombin	Bos taurus	117-125
7540063-4	1995	Neuraminidase treatment of CD34+ cells completely abrogated their binding to P-selectin, implying a prominent role for sialic acid in the structure and function of the P-selectin ligand on hematopoietic progenitors.	N-Acetylneuraminic Acid	119-130	neuraminidase 1	Homo sapiens	0-13
7540063-4	1995	Neuraminidase treatment of CD34+ cells completely abrogated their binding to P-selectin, implying a prominent role for sialic acid in the structure and function of the P-selectin ligand on hematopoietic progenitors.	N-Acetylneuraminic Acid	119-130	CD34 molecule	Homo sapiens	27-31
7540063-4	1995	Neuraminidase treatment of CD34+ cells completely abrogated their binding to P-selectin, implying a prominent role for sialic acid in the structure and function of the P-selectin ligand on hematopoietic progenitors.	N-Acetylneuraminic Acid	119-130	selectin P	Homo sapiens	77-87
7540063-4	1995	Neuraminidase treatment of CD34+ cells completely abrogated their binding to P-selectin, implying a prominent role for sialic acid in the structure and function of the P-selectin ligand on hematopoietic progenitors.	N-Acetylneuraminic Acid	119-130	selectin P	Homo sapiens	168-178
7652979-1	1995	Carbohydrate deficient transferrin (CDT) is an isoform of transferrin with a reduced carbohydrate content, especially the negatively charged sialic acid.	N-Acetylneuraminic Acid	141-152	transferrin	Homo sapiens	58-69
7540063-5	1995	Monoclonal antibodies (MoAbs) CSLEX-1 and HECA-452, which identify carbohydrate epitopes involving sialic acid, bound to 33% and 35% of CD34+ cells, respectively, and included the majority of CFU-GM and pre-CFU.	N-Acetylneuraminic Acid	99-110	hdc homolog, cell cycle regulator	Homo sapiens	42-46
7619404-0	1995	Tissue plasminogen activator coexpressed in Chinese hamster ovary cells with alpha(2,6)-sialyltransferase contains NeuAc alpha(2,6)Gal beta(1,4)Glc-N-AcR linkages.	N-Acetylneuraminic Acid	115-120	chromosome 20 open reading frame 181	Homo sapiens	0-28
18623330-11	1995	These data suggest that the presence and quantity of N-acetylneuraminic acid is an important component in predicting CTLA4lg plasma clearance rates and that production lots can be analyzed for oligosaccharide heterogeneity and sialic acid content by electrophoresis of fluorophore-conjugated carbohydrates.	N-Acetylneuraminic Acid	53-76	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	117-122
7554283-8	1995	Observations from both methods were consistent with an increase in bi-antennary chains terminating in alpha 2-6 sialic acid and possibly more alpha 1-6 fucose in the core of the unit.	N-Acetylneuraminic Acid	112-123	immunoglobulin binding protein 1	Homo sapiens	102-111
7541354-6	1995	The major oligosaccharides of human vitronectin were of the diantennary N-acetyllactosamine type, with a lesser amount of the tri- and a small amount of the mono-antennary type, to which 1-3 mol sialic acid residues were linked, mostly through alpha 2-6 linkages, although alpha 2-3 linkages were also present.	N-Acetylneuraminic Acid	195-206	vitronectin	Homo sapiens	36-47
7636624-3	1995	When O-acetylated sialic acid (neuraminidase-resistant) is converted by saponification to non-O-acetylated sialic acid (neuraminidase-sensitive), normal colorectal goblet cells (mainly of the lower two-thirds of crypts) are immunoreactive with the monoclonal antibody TKH2 (specific for STn).	N-Acetylneuraminic Acid	18-29	neuraminidase 1	Homo sapiens	31-44
7626509-3	1995	Analysis of desialylated hTeBG by isoelectric focusing (IEF) has revealed that microheterogeneity could be partly attributed to variability in sialic acid content or rearrangement of amino acid composition.	N-Acetylneuraminic Acid	143-154	sex hormone binding globulin	Homo sapiens	25-30
7766662-2	1995	ST6Gal I showed 4-7-times higher activity toward CMP-NeuGc than CMP-NeuAc, while for ST3Gal I there was no significant difference between them, irrespective of the origin of the enzymes.	N-Acetylneuraminic Acid	68-73	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	0-8
7619404-0	1995	Tissue plasminogen activator coexpressed in Chinese hamster ovary cells with alpha(2,6)-sialyltransferase contains NeuAc alpha(2,6)Gal beta(1,4)Glc-N-AcR linkages.	N-Acetylneuraminic Acid	115-120	beta-galactoside alpha-2,6-sialyltransferase 1	Cricetulus griseus	77-105
7619404-5	1995	SNA blots of partially purified tPA from the culture supernatant demonstrated that tPA synthesized in the 2,6-ST transfectants possessed terminal NeuAc alpha(2,6)Gal beta(1,4)Glc-N-AcR linkages, while tPA from the original recombinant CHO cell line did not.	N-Acetylneuraminic Acid	146-151	chromosome 20 open reading frame 181	Homo sapiens	83-86
7619404-5	1995	SNA blots of partially purified tPA from the culture supernatant demonstrated that tPA synthesized in the 2,6-ST transfectants possessed terminal NeuAc alpha(2,6)Gal beta(1,4)Glc-N-AcR linkages, while tPA from the original recombinant CHO cell line did not.	N-Acetylneuraminic Acid	146-151	chromosome 20 open reading frame 181	Homo sapiens	83-86
8586620-6	1995	The MSG-1 monoclonal antibody exhibited reactivity to ganglioside GM3(NeuAc).	N-Acetylneuraminic Acid	70-75	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	Mus musculus	4-9
7787299-6	1995	Approximately 7.2% of carbohydrate from PAS-4 was composed of mannose, galactose (Gal), N-acetylglucosamine, N-acetylgalactosamine (GalNAc), and sialic acid, most of the Gal and GalNAc in PAS-4 being released after mild alkaline hydrolysis.	N-Acetylneuraminic Acid	145-156	PAS-4	Bos taurus	40-45
7554557-2	1995	METHODS: Normal IgG1 and IgG3 were affinity-purified, and sialic acid and galactose were clipped off using neuraminidase and beta-galactosidase, respectively.	N-Acetylneuraminic Acid	58-69	neuraminidase 1	Homo sapiens	107-120
7554557-2	1995	METHODS: Normal IgG1 and IgG3 were affinity-purified, and sialic acid and galactose were clipped off using neuraminidase and beta-galactosidase, respectively.	N-Acetylneuraminic Acid	58-69	galactosidase beta 1	Homo sapiens	125-143
7655169-10	1995	The catalytic domain of the cloned sequence was expressed in transfected cells and was shown to be competent in mediating the specific synthesis of sialic acid alpha 2,3 to Gal(beta 1,3)GalNAc-R. Genomic sequences for SiaT-4a were also isolated and examined.	N-Acetylneuraminic Acid	148-159	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	218-225
7738493-9	1995	Serum sialic acid correlated strongly with plasma fibrinogen (r = 0.78; P &lt; 0.0001) and erythrocyte sedimentation rate (r = 0.62; P &lt; 0.0001).	N-Acetylneuraminic Acid	6-17	fibrinogen beta chain	Homo sapiens	50-60
7745007-9	1995	Further studies with hCG, asialo-hCG, asialoagalacto-hCG, and deglycosylated hCG revealed that removal of sialic acid caused a marked increase in both its affinity for hTSHr and its cAMP-releasing potency, whereas removal of further carbohydrate, although it slightly enhanced receptor binding, was detrimental to adenylate cyclase activation.	N-Acetylneuraminic Acid	106-117	hypertrichosis 2 (generalised, congenital)	Homo sapiens	21-24
7745007-9	1995	Further studies with hCG, asialo-hCG, asialoagalacto-hCG, and deglycosylated hCG revealed that removal of sialic acid caused a marked increase in both its affinity for hTSHr and its cAMP-releasing potency, whereas removal of further carbohydrate, although it slightly enhanced receptor binding, was detrimental to adenylate cyclase activation.	N-Acetylneuraminic Acid	106-117	hypertrichosis 2 (generalised, congenital)	Homo sapiens	33-36
7745007-9	1995	Further studies with hCG, asialo-hCG, asialoagalacto-hCG, and deglycosylated hCG revealed that removal of sialic acid caused a marked increase in both its affinity for hTSHr and its cAMP-releasing potency, whereas removal of further carbohydrate, although it slightly enhanced receptor binding, was detrimental to adenylate cyclase activation.	N-Acetylneuraminic Acid	106-117	hypertrichosis 2 (generalised, congenital)	Homo sapiens	33-36
7745007-9	1995	Further studies with hCG, asialo-hCG, asialoagalacto-hCG, and deglycosylated hCG revealed that removal of sialic acid caused a marked increase in both its affinity for hTSHr and its cAMP-releasing potency, whereas removal of further carbohydrate, although it slightly enhanced receptor binding, was detrimental to adenylate cyclase activation.	N-Acetylneuraminic Acid	106-117	hypertrichosis 2 (generalised, congenital)	Homo sapiens	33-36
7745007-9	1995	Further studies with hCG, asialo-hCG, asialoagalacto-hCG, and deglycosylated hCG revealed that removal of sialic acid caused a marked increase in both its affinity for hTSHr and its cAMP-releasing potency, whereas removal of further carbohydrate, although it slightly enhanced receptor binding, was detrimental to adenylate cyclase activation.	N-Acetylneuraminic Acid	106-117	thyroid stimulating hormone receptor	Homo sapiens	168-173
7648442-9	1995	The results also suggested that the terminal sialic acid of the sugar chains in natural human interferon-beta significantly affects its pharmacokinetics and biologic activities.	N-Acetylneuraminic Acid	45-56	interferon beta 1	Homo sapiens	94-109
7545761-4	1995	Experiments involving lectin binding and glycosidase treatment demonstrated that the higher molecular weight of MAG in the quaking mutant was due to a higher content of N-acetylneuraminic acid residues linked alpha 2-3 to galactose as well as to more branching of oligosaccharide moieties indicated by a higher content of subterminal galactose residues.	N-Acetylneuraminic Acid	169-192	myelin-associated glycoprotein	Mus musculus	112-115
7545761-4	1995	Experiments involving lectin binding and glycosidase treatment demonstrated that the higher molecular weight of MAG in the quaking mutant was due to a higher content of N-acetylneuraminic acid residues linked alpha 2-3 to galactose as well as to more branching of oligosaccharide moieties indicated by a higher content of subterminal galactose residues.	N-Acetylneuraminic Acid	169-192	quaking, KH domain containing RNA binding	Mus musculus	123-130
7545761-5	1995	The total sialic acid measured by HPAE-chromatography in purified quaking MAG was 40% higher than in control MAG.	N-Acetylneuraminic Acid	10-21	quaking, KH domain containing RNA binding	Mus musculus	66-73
7545761-5	1995	The total sialic acid measured by HPAE-chromatography in purified quaking MAG was 40% higher than in control MAG.	N-Acetylneuraminic Acid	10-21	myelin-associated glycoprotein	Mus musculus	74-77
7545761-5	1995	The total sialic acid measured by HPAE-chromatography in purified quaking MAG was 40% higher than in control MAG.	N-Acetylneuraminic Acid	10-21	myelin-associated glycoprotein	Mus musculus	109-112
7749766-6	1995	Fibrinogen was purified via glycine precipitation, and the sialic acid (SA) content was determined.	N-Acetylneuraminic Acid	59-70	fibrinogen beta chain	Homo sapiens	0-10
7749766-6	1995	Fibrinogen was purified via glycine precipitation, and the sialic acid (SA) content was determined.	N-Acetylneuraminic Acid	72-74	fibrinogen beta chain	Homo sapiens	0-10
7537381-1	1995	The B-cell receptor CD22 binds sialic acid linked alpha-2-6 to terminal galactose residues on N-linked oligosaccharides associated with several cell-surface glycoproteins.	N-Acetylneuraminic Acid	31-42	CD22 molecule	Homo sapiens	4-24
7749766-12	1995	CONCLUSIONS: These data support the notion that an altered fibrinogen exists in some children with nephrotic syndrome characterized by an increased TT and RT, elevated fibrinogen, and both an increased negative charge and SA content.	N-Acetylneuraminic Acid	222-224	fibrinogen beta chain	Homo sapiens	59-69
8597831-1	1995	We report a case of infantile sialic acid storage disease (ISSD) in a black infant presenting in utero with nonimmune hydrops, ascites, and anemia requiring intrauterine transfusion.	N-Acetylneuraminic Acid	30-41	solute carrier family 17 member 5	Homo sapiens	59-63
8597831-8	1995	Demonstration of elevated free sialic acid in urine, amniotic fluid, and cultured fibroblasts confirmed the diagnosis of ISSD.	N-Acetylneuraminic Acid	31-42	solute carrier family 17 member 5	Homo sapiens	121-125
7537381-1	1995	The B-cell receptor CD22 binds sialic acid linked alpha-2-6 to terminal galactose residues on N-linked oligosaccharides associated with several cell-surface glycoproteins.	N-Acetylneuraminic Acid	31-42	immunoglobulin binding protein 1	Homo sapiens	50-59
7537381-5	1995	We also show that addition of sialic acid by beta-galactoside alpha-2,6-sialyltransferase to the CD22 molecule abrogates interactions between CD22 and its ligands.	N-Acetylneuraminic Acid	30-41	CD22 molecule	Homo sapiens	97-101
7537381-5	1995	We also show that addition of sialic acid by beta-galactoside alpha-2,6-sialyltransferase to the CD22 molecule abrogates interactions between CD22 and its ligands.	N-Acetylneuraminic Acid	30-41	CD22 molecule	Homo sapiens	142-146
7718872-2	1995	It shares sequence similarity with sialoadhesin, CD22, and the myelin-associated glycoprotein, which constitute the Sialoadhesin family of sialic acid-dependent cell adhesion molecules.	N-Acetylneuraminic Acid	139-150	sialic acid binding Ig like lectin 1	Homo sapiens	35-47
7718872-2	1995	It shares sequence similarity with sialoadhesin, CD22, and the myelin-associated glycoprotein, which constitute the Sialoadhesin family of sialic acid-dependent cell adhesion molecules.	N-Acetylneuraminic Acid	139-150	CD22 molecule	Homo sapiens	49-53
7718872-8	1995	Pretreatment of the CD33-transfected cells with sialidase rendered them capable of mediating sialic acid-dependent binding.	N-Acetylneuraminic Acid	93-104	CD33 molecule	Homo sapiens	20-24
7718872-2	1995	It shares sequence similarity with sialoadhesin, CD22, and the myelin-associated glycoprotein, which constitute the Sialoadhesin family of sialic acid-dependent cell adhesion molecules.	N-Acetylneuraminic Acid	139-150	myelin associated glycoprotein	Homo sapiens	63-93
7718872-9	1995	These results show that CD33 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.	N-Acetylneuraminic Acid	47-58	CD33 molecule	Homo sapiens	24-28
7718872-9	1995	These results show that CD33 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.	N-Acetylneuraminic Acid	47-58	CD33 molecule	Homo sapiens	166-170
7718872-2	1995	It shares sequence similarity with sialoadhesin, CD22, and the myelin-associated glycoprotein, which constitute the Sialoadhesin family of sialic acid-dependent cell adhesion molecules.	N-Acetylneuraminic Acid	139-150	sialic acid binding Ig like lectin 1	Homo sapiens	116-128
7718872-5	1995	A recombinant soluble form of CD33, Fc-CD33, bound red blood cells with a specificity similar to that of sialoadhesin, preferring NeuAc alpha 2,3Gal in N- and O-glycans over NeuAc alpha 2,6Gal in N-glycans.	N-Acetylneuraminic Acid	130-135	CD33 molecule	Homo sapiens	30-34
7718872-5	1995	A recombinant soluble form of CD33, Fc-CD33, bound red blood cells with a specificity similar to that of sialoadhesin, preferring NeuAc alpha 2,3Gal in N- and O-glycans over NeuAc alpha 2,6Gal in N-glycans.	N-Acetylneuraminic Acid	174-179	CD33 molecule	Homo sapiens	30-34
7718872-5	1995	A recombinant soluble form of CD33, Fc-CD33, bound red blood cells with a specificity similar to that of sialoadhesin, preferring NeuAc alpha 2,3Gal in N- and O-glycans over NeuAc alpha 2,6Gal in N-glycans.	N-Acetylneuraminic Acid	174-179	CD33 molecule	Homo sapiens	39-43
7720864-0	1995	Deficiency of ganglioside biosynthesis in metastatic human melanoma cells: relevance of CMP-NeuAc:LacCer alpha 2-3 sialyltransferase (GM3 synthase).	N-Acetylneuraminic Acid	92-97	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	134-146
7537669-1	1995	Previous studies on T cell activation via CD43 antigen stimulation were limited to the use of L10, a monoclonal antibody (mAb) recognizing a sialic acid-independent epitope on the CD43 molecule.	N-Acetylneuraminic Acid	141-152	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	94-97
7717992-7	1995	Native rat milk Tf is separated into four bands on native PAGE that differ only in their sialic acid content: one biantennary glycan is present containing either no sialic acid residues or up to three.	N-Acetylneuraminic Acid	89-100	transferrin	Rattus norvegicus	16-18
7717992-7	1995	Native rat milk Tf is separated into four bands on native PAGE that differ only in their sialic acid content: one biantennary glycan is present containing either no sialic acid residues or up to three.	N-Acetylneuraminic Acid	165-176	transferrin	Rattus norvegicus	16-18
7639100-1	1995	The neural cell-adhesion molecule, NCAM, contains an unusual homopolymer of sialic acid units, polysialic acid.	N-Acetylneuraminic Acid	76-87	neural cell adhesion molecule 1	Rattus norvegicus	4-39
7622610-3	1995	The major mucin fraction isolated was characterized by a high hydroxy amino acid content (40%), a Thr/Ser ratio of 1.52, a high sialic acid content, and a low sulfate content.	N-Acetylneuraminic Acid	128-139	LOC100508689	Homo sapiens	10-15
7706299-2	1995	CD22, a B cell-specific receptor of the immunoglobulin superfamily, has been demonstrated to bind to oligosaccharides containing alpha 2-6-linked sialic acid (Sia) residues.	N-Acetylneuraminic Acid	159-162	B-cell receptor CD22	Cricetulus griseus	0-4
7706300-8	1995	This modest change is sufficient to cause a marked increase in alpha 2-6-linked sialic acid-dependent binding of Chinese hamster ovary (CHO) cells expressing recombinant human CD22.	N-Acetylneuraminic Acid	80-91	CD22 molecule	Homo sapiens	176-180
7706300-12	1995	Furthermore, coexpression of beta-galactoside alpha 2,6-sialyltransferase with CD22 in the CHO cells abrogates sialic acid-dependent binding to cytokine-activated HEC.	N-Acetylneuraminic Acid	111-122	B-cell receptor CD22	Cricetulus griseus	79-83
7706300-14	1995	Thus, CD22-mediated interactions between B cells and activated vascular endothelium may be positively regulated by induction of alpha 2-6-linked sialic acid-bearing endothelial cell ligands, but negatively regulated by such ligands on the B cells expressing CD22.	N-Acetylneuraminic Acid	145-156	CD22 molecule	Homo sapiens	6-10
7706301-2	1995	CD22 is a cell-surface receptor of resting mature B cells that recognizes sialic acid (Sia) in the natural structure Sia alpha 2-6Gal beta 1-4GlcNAc (Powell, L. D., Jain, R. K., Matta, K. L., Sabesan, S., and Varki, A.	N-Acetylneuraminic Acid	74-85	CD22 molecule	Homo sapiens	0-4
7706301-2	1995	CD22 is a cell-surface receptor of resting mature B cells that recognizes sialic acid (Sia) in the natural structure Sia alpha 2-6Gal beta 1-4GlcNAc (Powell, L. D., Jain, R. K., Matta, K. L., Sabesan, S., and Varki, A.	N-Acetylneuraminic Acid	87-90	CD22 molecule	Homo sapiens	0-4
7535343-0	1995	Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand.	N-Acetylneuraminic Acid	119-130	CD22 molecule	Homo sapiens	48-52
7535343-2	1995	CD22 is unique among members of the Ig superfamily in that it has been suggested to bind a series of sialic acid-dependent ligands, potentially through different functional domains expressed by different splice variants of CD22.	N-Acetylneuraminic Acid	101-112	CD22 molecule	Homo sapiens	0-4
7535343-2	1995	CD22 is unique among members of the Ig superfamily in that it has been suggested to bind a series of sialic acid-dependent ligands, potentially through different functional domains expressed by different splice variants of CD22.	N-Acetylneuraminic Acid	101-112	CD22 molecule	Homo sapiens	223-227
7541505-7	1995	In the capillaries, lectin binding to endothelial galactose, fucose, and sialic acid increased significantly from Day 5.5 to Day 6.0.	N-Acetylneuraminic Acid	73-84	galectin 3	Gallus gallus	20-26
7742784-0	1995	The effects of pH on the generation of turbidity and elasticity associated with fibrinogen-fibrin conversion by thrombin are remarkably influenced by sialic acid in fibrinogen.	N-Acetylneuraminic Acid	150-161	fibrinogen beta chain	Homo sapiens	80-90
7757221-0	1995	High-performance affinity chromatography of insulin on coated silica grafted with sialic acid.	N-Acetylneuraminic Acid	82-93	insulin	Homo sapiens	44-51
7757221-11	1995	However, it is important to determine and optimize the conditions for adsorption and desorption of insulin on supports grafted with sialic acid and to estimate the chromatographic performances of these active phases.	N-Acetylneuraminic Acid	132-143	insulin	Homo sapiens	99-106
7742784-0	1995	The effects of pH on the generation of turbidity and elasticity associated with fibrinogen-fibrin conversion by thrombin are remarkably influenced by sialic acid in fibrinogen.	N-Acetylneuraminic Acid	150-161	coagulation factor II, thrombin	Homo sapiens	112-120
7742784-0	1995	The effects of pH on the generation of turbidity and elasticity associated with fibrinogen-fibrin conversion by thrombin are remarkably influenced by sialic acid in fibrinogen.	N-Acetylneuraminic Acid	150-161	fibrinogen beta chain	Homo sapiens	165-175
7742784-6	1995	Concerning the elasticity evaluated by thromboelastography, the coagulation time (k) and the maximum amplitude (ma) were lower in asialofibrinogen, indicating a deterioration of the clotting function of fibrinogen with the loss of sialic acid.	N-Acetylneuraminic Acid	231-242	fibrinogen beta chain	Homo sapiens	136-146
7742784-7	1995	These results suggest that sialic acid bound to fibrinogen is closely related to the fibrin network formation in blood coagulation, which is the most important function of fibrinogen, and plays a functional role in the stabilization of fibrin clot formation against environmental changes, including pH.	N-Acetylneuraminic Acid	27-38	fibrinogen beta chain	Homo sapiens	48-58
7742784-7	1995	These results suggest that sialic acid bound to fibrinogen is closely related to the fibrin network formation in blood coagulation, which is the most important function of fibrinogen, and plays a functional role in the stabilization of fibrin clot formation against environmental changes, including pH.	N-Acetylneuraminic Acid	27-38	fibrinogen beta chain	Homo sapiens	172-182
7532186-1	1995	Sialoadhesin is a macrophage-restricted, sialic acid-dependent receptor of 185 kD that binds to the oligosaccharide sequence NeuAc alpha 2,3Gal on cell surface glycoconjugates.	N-Acetylneuraminic Acid	125-130	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	0-12
7795413-5	1995	In contrast, sialyl or sulfate group on C-6 and sulfate on C-3 of Gal in Gal beta 1,3GalNAc alpha- inhibited almost completely the interaction of PNA with ACGM but had only a slight effect on the interaction of ABA; C-6 substitution with either sialic acid or sulfate on GalNAc alpha- almost abolished the interaction of both HPA and VVA with ACGM.	N-Acetylneuraminic Acid	245-256	complement C6	Homo sapiens	40-43
7795415-1	1995	A method for the separation of O-linked oligosaccharides into neutral, sialic acid-containing and sulfated species was applied to oligosaccharides released by alkaline borohydride from mucin glycopeptides from porcine small intestine.	N-Acetylneuraminic Acid	71-82	LOC100508689	Homo sapiens	185-190
7867650-3	1995	hCG derivatives were obtained by enzymic removal of the alpha 3-linked sialic acid residues followed by alpha 6-sialylation, alpha 3-galactosylation or alpha 3-fucosylation of uncovered Gal beta 1--&gt;4GlcNAc (LacNAc) termini, or alpha 3-sialylation of Gal beta 1--&gt;3GalNAc sequences.	N-Acetylneuraminic Acid	71-82	chorionic gonadotropin subunit beta 5	Homo sapiens	0-3
7829476-5	1995	The Ki of the donor substrate analog CDP was also evaluated for the recombinant sialyltransferase with the Val to Ala mutation at residue 220, which produced a 6-fold increase in Km of CMP-NeuAc.	N-Acetylneuraminic Acid	189-194	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	80-97
7719410-5	1995	The elevation of the urinary ratio of this sialylated oligosaccharide to free sialic acid observed in some advanced cancer patients in this study may reflect the elevation of sialyltransferase activity in tumor tissues.	N-Acetylneuraminic Acid	78-89	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	175-192
7608469-8	1995	The sialic acid content of the hFSH isoforms was also observed to be related to the hormonal specific activity in a radioreceptor assay, confirming that alterations in the carbohydrate structure can influence the FSH-receptor interaction.	N-Acetylneuraminic Acid	4-15	follicle stimulating hormone receptor	Homo sapiens	213-225
7822786-8	1995	Sialic acid residues on CD43 contributed to the CD43 protective effect.	N-Acetylneuraminic Acid	0-11	sialophorin	Homo sapiens	24-28
7822786-8	1995	Sialic acid residues on CD43 contributed to the CD43 protective effect.	N-Acetylneuraminic Acid	0-11	sialophorin	Homo sapiens	48-52
7829476-7	1995	Taken together, these results suggest that the conserved sialylmotif in the sialyltransferase gene family participates in the binding of the common donor substrate, CMP-NeuAc.	N-Acetylneuraminic Acid	169-174	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	76-93
7627722-5	1995	Among the patients with abnormal levels of alpha 1-antichymotrypsin and sialic acid, those who received PSK may have a significantly better survival than those without PSK.	N-Acetylneuraminic Acid	72-83	TAO kinase 2	Homo sapiens	104-107
7653160-2	1995	Glycan chain analysis performed with the use of a Glycan Differentiation Kit showed that basic forms of arylsulfatase B from human placenta contained mostly high mannose/hybrid type glycans, with 6-O-L-fucose bound to the innermost N-acetylglucosamine residue, whereas acidic forms of the enzyme contained complex type glycans containing fucose and sialic acid.	N-Acetylneuraminic Acid	349-360	arylsulfatase B	Homo sapiens	104-119
7528574-8	1995	We found that the serum-derived soluble Kit is glycosylated, with mostly N-linked but also O-linked carbohydrate, and with terminal sialic acid residues.	N-Acetylneuraminic Acid	132-143	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	40-43
7627722-6	1995	These results indicate that the preoperative serum levels of alpha 1-antichymotrypsin and sialic acid may possibly predict the effectiveness of immunotherapy using PSK.	N-Acetylneuraminic Acid	90-101	TAO kinase 2	Homo sapiens	164-167
7991134-1	1994	We report a patient with an acute, self-limiting neuropathy consisting of ataxia and areflexia, but without ophthalmoplegia or limb weakness, with transient, high-titer serum IgG antibodies to a single NeuAc(alpha 2-8)NeuAc-linked disialosyl epitope, as found on GD1b and GD3 gangliosides.	N-Acetylneuraminic Acid	202-207	GRDX	Homo sapiens	272-275
8717231-4	1995	The N-linked oligosaccharides were released from EPO by the treatment with N-glycosidase F. HPAEC analysis of oligosaccharide standards revealed that elution time of sialylated oligosaccharides were dependent on the number of sialic acid, which contributed to the activity of EPO.	N-Acetylneuraminic Acid	226-237	erythropoietin	Cricetulus griseus	49-52
7584519-0	1995	Crude urinary human chorionic gonadotropin contains variant forms of HCG with low sialic acid content that exhibit an increased thyrotropic activity in CHO cells expressing the human TSH receptor.	N-Acetylneuraminic Acid	82-93	chorionic gonadotropin subunit beta 5	Homo sapiens	69-72
7584519-10	1995	Isoelectric focusing and direct measurement of sialic acid contents revealed hCGv to be less sialylated than hCGp.	N-Acetylneuraminic Acid	47-58	protein phosphatase 1 regulatory inhibitor subunit 11	Homo sapiens	77-81
7696986-0	1994	Relationship between gamma-glutamyl transpeptidase activity and sialic acid content in some organs and brain regions of the developing rat.	N-Acetylneuraminic Acid	64-75	gamma-glutamyltransferase 1	Rattus norvegicus	21-50
7696986-6	1994	It can be concluded that in spite of an apparent relationship between GGT activity and membrane sialylation, the amount of SA linked to the GGT molecule is not related to differences in enzyme activity.	N-Acetylneuraminic Acid	123-125	gamma-glutamyltransferase 1	Rattus norvegicus	140-143
7858952-8	1995	Of all the monosaccharides tested, only N-acetylneuraminic acid exerted an inhibitory effect on AChE activity.	N-Acetylneuraminic Acid	40-63	acetylcholinesterase	Ovis aries	96-100
8536062-9	1995	HCG beta cf showed microheterogeneity related to its sialic acid content.	N-Acetylneuraminic Acid	53-64	chorionic gonadotropin subunit beta 3	Homo sapiens	0-8
7539788-1	1995	Recombinant human erythropoietin (EPO) produced by Chinese hamster ovary cells and distributed by two different pharmaceutical companies were confirmed to contain about 1% N-glycolylneuraminic acid (Neu5Gc) in total sialic acid content.	N-Acetylneuraminic Acid	216-227	erythropoietin	Homo sapiens	18-32
7539788-1	1995	Recombinant human erythropoietin (EPO) produced by Chinese hamster ovary cells and distributed by two different pharmaceutical companies were confirmed to contain about 1% N-glycolylneuraminic acid (Neu5Gc) in total sialic acid content.	N-Acetylneuraminic Acid	216-227	erythropoietin	Homo sapiens	34-37
7803516-0	1994	Role of sialic acid residues in the in vitro superactivity of human choriogonadotropin (hCG) in rat Leydig cells.	N-Acetylneuraminic Acid	8-19	chorionic gonadotropin subunit beta 5	Homo sapiens	88-91
7803516-4	1994	The removal of sialic acid residues with neuraminidase dramatically diminished hCG stimulating activity without impairing its receptor binding activity but the S/B ratio for asialo-hCG never reached values lower than 1.	N-Acetylneuraminic Acid	15-26	chorionic gonadotropin subunit beta 5	Homo sapiens	79-82
7803516-6	1994	Sialic acid residues in the Asn beta 30 carbohydrate chains of hLH and hCG appear to be responsible for their superactivity in the in vitro stimulation of testosterone secretion by rat Leydig cells.	N-Acetylneuraminic Acid	0-11	chorionic gonadotropin subunit beta 5	Homo sapiens	71-74
7734842-7	1994	The TSH receptor (TSH-R) ganglioside belongs to the gangliotetraose family, having sialic acid attached to both galactose molecules.	N-Acetylneuraminic Acid	83-94	thyroid stimulating hormone receptor	Rattus norvegicus	4-16
7734842-7	1994	The TSH receptor (TSH-R) ganglioside belongs to the gangliotetraose family, having sialic acid attached to both galactose molecules.	N-Acetylneuraminic Acid	83-94	thyroid stimulating hormone receptor	Rattus norvegicus	18-23
7960097-2	1994	This interaction requires sialic acid residues of SAG and divalent cations and may mediate the colonization of oral tissues by this organism.	N-Acetylneuraminic Acid	26-37	deleted in malignant brain tumors 1	Homo sapiens	50-53
7697870-9	1994	Taken together, these results suggest differential glycosylation of rat DAT occurs during postnatal development and aging; the increase is due to increases in the N-linked sugars rather than changes in either sialic acid content or the polypeptide.	N-Acetylneuraminic Acid	209-220	solute carrier family 6 member 3	Rattus norvegicus	72-75
7999055-0	1994	Role of sialic acid on the viscosity of canine tracheal mucin glycoprotein.	N-Acetylneuraminic Acid	8-19	mucin	Canis lupus familiaris	56-61
7999055-1	1994	The role of sialic acid on the viscosity of canine tracheal mucin (CTM) was investigated.	N-Acetylneuraminic Acid	12-23	mucin	Canis lupus familiaris	60-65
7523509-9	1994	The P-selectin interaction is similar to the rolling event mediated by E-selectin--it requires divalent cations and sialic acid on the lymphocyte, it lacks involvement of L-selectin and CD44, and rolling occurs under physiologic shear conditions.	N-Acetylneuraminic Acid	116-127	selectin P	Bos taurus	4-14
7533044-0	1994	Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily.	N-Acetylneuraminic Acid	77-88	sialic acid binding Ig like lectin 1	Homo sapiens	0-12
7533044-0	1994	Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily.	N-Acetylneuraminic Acid	77-88	myelin associated glycoprotein	Homo sapiens	14-44
7533044-0	1994	Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily.	N-Acetylneuraminic Acid	77-88	CD22 molecule	Homo sapiens	49-53
7533044-2	1994	Apart from the selectins, the only well-characterized vertebrate sialic acid-dependent adhesion molecules are CD22 and sialoadhesin; CD22 is a member of the immunoglobulin superfamily that is expressed by B lymphocytes and sialoadhesin is a macrophage receptor.	N-Acetylneuraminic Acid	65-76	CD22 molecule	Homo sapiens	110-114
7533044-2	1994	Apart from the selectins, the only well-characterized vertebrate sialic acid-dependent adhesion molecules are CD22 and sialoadhesin; CD22 is a member of the immunoglobulin superfamily that is expressed by B lymphocytes and sialoadhesin is a macrophage receptor.	N-Acetylneuraminic Acid	65-76	sialic acid binding Ig like lectin 1	Homo sapiens	119-131
7533044-2	1994	Apart from the selectins, the only well-characterized vertebrate sialic acid-dependent adhesion molecules are CD22 and sialoadhesin; CD22 is a member of the immunoglobulin superfamily that is expressed by B lymphocytes and sialoadhesin is a macrophage receptor.	N-Acetylneuraminic Acid	65-76	CD22 molecule	Homo sapiens	133-137
7533044-2	1994	Apart from the selectins, the only well-characterized vertebrate sialic acid-dependent adhesion molecules are CD22 and sialoadhesin; CD22 is a member of the immunoglobulin superfamily that is expressed by B lymphocytes and sialoadhesin is a macrophage receptor.	N-Acetylneuraminic Acid	65-76	sialic acid binding Ig like lectin 1	Homo sapiens	223-235
7533044-4	1994	Both proteins share sequence similarity with the myelin-associated glycoprotein, an adhesion molecule of oligodendrocytes and Schwann cells that has been implicated in the process of myelination, raising the important question of whether myelin-associated glycoprotein is also a sialic acid-binding protein.	N-Acetylneuraminic Acid	279-290	myelin associated glycoprotein	Homo sapiens	49-79
7980600-2	1994	Variability in the CEA molecules was observed in terms of monoclonal antibody binding, apparent molecular weight and sialic acid content, although this was not cell type specific.	N-Acetylneuraminic Acid	117-128	CEA cell adhesion molecule 3	Homo sapiens	19-22
7980600-3	1994	CEA was found to mediate homotypic as well as heterotypic intercellular adhesion independently of the cell type and despite differences in the sialic acid content.	N-Acetylneuraminic Acid	143-154	CEA cell adhesion molecule 3	Homo sapiens	0-3
7523509-9	1994	The P-selectin interaction is similar to the rolling event mediated by E-selectin--it requires divalent cations and sialic acid on the lymphocyte, it lacks involvement of L-selectin and CD44, and rolling occurs under physiologic shear conditions.	N-Acetylneuraminic Acid	116-127	selectin E	Bos taurus	71-81
7926020-4	1994	Thus it was concluded that the DU-PAN-2 reactive ganglioside in the tumor is IV3 alpha NeuAc-Lc4Cer and that DU-PAN-2 has a rather broad specificity.	N-Acetylneuraminic Acid	87-92	poly(A) specific ribonuclease subunit PAN2	Homo sapiens	34-39
7523493-9	1994	Interestingly, removal of sialic acid by neuraminidase treatment of 1B11-negative CD4+ T lymphocytes or 1B11-negative EL4 cells confers 1B11 reactivity, suggesting that the 1B11 epitope is masked by sialic acid residues on the CD43 115-kDa isoform.	N-Acetylneuraminic Acid	26-37	sialophorin	Mus musculus	227-231
8000551-5	1994	Pre-treatment of HeLa cell monolayers with neuraminidase significantly reduced ureaplasma adherence and, using a novel "immunoblot adherence assay", ureaplasmas were shown to bind to a number of HeLa cell components, three of which appear to terminate in sialic acid.	N-Acetylneuraminic Acid	255-266	neuraminidase 1	Homo sapiens	43-56
7925291-1	1994	Sialoadhesin is a macrophage-restricted adhesion molecule of 185 kDa that mediates sialic acid-dependent binding to cells.	N-Acetylneuraminic Acid	83-94	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	0-12
7925291-4	1994	COS cells transfected with a cDNA encoding full-length sialoadhesin bound mouse bone marrow cells in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	103-114	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	55-67
7925291-6	1994	When immobilized on plastic, the 16-domain form bound cells in a sialic acid-dependent manner, suggesting that sialoadhesin can function in both secreted and membrane-bound forms.	N-Acetylneuraminic Acid	65-76	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	111-123
7925291-8	1994	Like sialoadhesin, CD22 mediates sialic acid-dependent cell adhesion.	N-Acetylneuraminic Acid	33-44	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	5-17
7925291-8	1994	Like sialoadhesin, CD22 mediates sialic acid-dependent cell adhesion.	N-Acetylneuraminic Acid	33-44	CD22 antigen	Mus musculus	19-23
7925291-9	1994	The sequence similarity of sialoadhesin to CD22 and related members of the Ig superfamily indicates the existence of a novel family of sialic acid binding proteins involved in cell-cell interactions.	N-Acetylneuraminic Acid	135-146	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	27-39
7925291-9	1994	The sequence similarity of sialoadhesin to CD22 and related members of the Ig superfamily indicates the existence of a novel family of sialic acid binding proteins involved in cell-cell interactions.	N-Acetylneuraminic Acid	135-146	CD22 antigen	Mus musculus	43-47
8070085-4	1994	THP from healthy probands had a high sialic acid content (51 +/- 9 g/kg), whereas THP from recurrent stone formers had a decreased sialic acid content (21 +/- 4 g/kg).	N-Acetylneuraminic Acid	37-48	uromodulin	Homo sapiens	0-3
7529007-6	1994	Removal of sialic acid from CEA by neuraminidase digestion abrogates the binding.	N-Acetylneuraminic Acid	11-22	CEA cell adhesion molecule 3	Homo sapiens	28-31
7529007-6	1994	Removal of sialic acid from CEA by neuraminidase digestion abrogates the binding.	N-Acetylneuraminic Acid	11-22	neuraminidase 1	Homo sapiens	35-48
7996715-5	1994	Increases of serum sialic acid highly accompanied with increases of CRP, alpha 1 or alpha 2 fraction of serum protein and elevation of erythrocyte sedimentation rate (ESR), indicating that serum sialic acid levels reflected more strictly inflammatory status than ESR.	N-Acetylneuraminic Acid	19-30	C-reactive protein	Homo sapiens	68-91
7996715-6	1994	There is a relatively good correlation (r = 0.813) between serum sialic acid values and the total amounts of alpha 1 and alpha 2 protein fraction, while poor correlations were shown between CRP and sialic acid values (r = 0.606), or ESR and sialic acid values (r = 0.671).	N-Acetylneuraminic Acid	65-76	adrenoceptor alpha 1D	Homo sapiens	109-128
8070085-4	1994	THP from healthy probands had a high sialic acid content (51 +/- 9 g/kg), whereas THP from recurrent stone formers had a decreased sialic acid content (21 +/- 4 g/kg).	N-Acetylneuraminic Acid	131-142	uromodulin	Homo sapiens	82-85
7989512-7	1994	Specific binding studies and Scatchard analysis revealed that 125I-labelled human SABP ligand can bind to human spermatozoa with a Ka = 2.6 x 10(9) M-1, their receptors probably being glycoconjugates having a terminal sialic acid moiety, since the sperm-protein interaction could also be abolished when spermatozoa were desialylated with neuraminidase.	N-Acetylneuraminic Acid	218-229	prolactin induced protein	Homo sapiens	82-86
7820229-6	1994	Similarly, the neuraminidase-labile sialic acid was 26.4 +/- 4.3 nmol 10(-9) platelets for fresh platelets and 17.6 +/- 4.0 nmol 10(-9) platelets after cryopreservation, P &lt; 0.001.	N-Acetylneuraminic Acid	36-47	neuraminidase 1	Homo sapiens	15-28
7530070-8	1994	Increasing the level of ammonium ion in the culture medium is shown to reduce the percentage of G-CSF produced with sialic acid linked alpha (2,6) to N-acetylgalactosamine.	N-Acetylneuraminic Acid	116-127	granulocyte colony-stimulating factor	Cricetulus griseus	96-101
8048628-6	1994	These data suggest that the isoelectric and glycoform heterogeneity of active renin are, in fact, closely related and may result from variable and interrelated mannose (Con A affinity) and sialic acid (charge) attachments to renin.	N-Acetylneuraminic Acid	189-200	renin	Rattus norvegicus	78-83
8048628-6	1994	These data suggest that the isoelectric and glycoform heterogeneity of active renin are, in fact, closely related and may result from variable and interrelated mannose (Con A affinity) and sialic acid (charge) attachments to renin.	N-Acetylneuraminic Acid	189-200	renin	Rattus norvegicus	225-230
7528204-0	1994	Expression of gangliosides GM3 (NeuAc) and GM3 (NeuGc) in myelomas and hybridomas of mouse, rat, and human origin.	N-Acetylneuraminic Acid	32-37	granulocyte macrophage antigen 3	Mus musculus	27-30
7528204-6	1994	Normally, human cells do not express NeuGc, and an Epstein-Barr virus-transformed human B lymphocyte line analyzed in this study retained this sialylation status, expressing exclusively GM3 (NeuAc) (100%).	N-Acetylneuraminic Acid	191-196	granulocyte macrophage antigen 3	Mus musculus	186-189
8182079-3	1994	Expression of the COOH-terminal catalytic domain of Fuc-TVII showed an alpha 1,3-fucosyltransferase activity for a type II oligosaccharide with a terminal alpha 2,3-linked sialic acid among various acceptors, consistent with that in vivo acceptor specificity.	N-Acetylneuraminic Acid	172-183	fucosyltransferase 7	Homo sapiens	52-60
8207002-1	1994	The sialyl Lewis x determinant (NeuAc alpha 2,3Gal beta 1, 4[Fuc alpha 1,3]GlcNAc) is an essential component of leukocyte counterreceptors for E-selectin and P-selectin.	N-Acetylneuraminic Acid	32-37	selectin E	Homo sapiens	143-153
8207002-1	1994	The sialyl Lewis x determinant (NeuAc alpha 2,3Gal beta 1, 4[Fuc alpha 1,3]GlcNAc) is an essential component of leukocyte counterreceptors for E-selectin and P-selectin.	N-Acetylneuraminic Acid	32-37	selectin P	Homo sapiens	158-168
7943950-5	1994	BoLA class I molecules appear to be glycosylated at a single N-linked position with a complex type carbohydrate moiety which has up to three terminal sialic acid residues.	N-Acetylneuraminic Acid	150-161	MHC class I antigen clone 2	Bos taurus	0-4
7980871-2	1994	Besides N-acetylneuraminic acid-dependent cell agglutination it also binds to a macrophage migration inhibitory factor (MIF).	N-Acetylneuraminic Acid	8-31	macrophage migration inhibitory factor	Homo sapiens	80-118
7980871-2	1994	Besides N-acetylneuraminic acid-dependent cell agglutination it also binds to a macrophage migration inhibitory factor (MIF).	N-Acetylneuraminic Acid	8-31	macrophage migration inhibitory factor	Homo sapiens	120-123
7927504-4	1994	Removal of sialic acid and N-linked glycan chains greatly increased the C3b-fixing properties of normal serum IgA1 and IgA2.	N-Acetylneuraminic Acid	11-22	complement C3	Homo sapiens	72-75
7927504-4	1994	Removal of sialic acid and N-linked glycan chains greatly increased the C3b-fixing properties of normal serum IgA1 and IgA2.	N-Acetylneuraminic Acid	11-22	immunoglobulin heavy constant alpha 1	Homo sapiens	110-114
7927504-5	1994	Myeloma IgA1 and IgA2 proteins and secretory IgA had higher C3b-binding activity than normal serum IgA, and this was further increased by removal of sialic acid and N-linked glycans.	N-Acetylneuraminic Acid	149-160	immunoglobulin heavy constant alpha 1	Homo sapiens	8-12
7927504-5	1994	Myeloma IgA1 and IgA2 proteins and secretory IgA had higher C3b-binding activity than normal serum IgA, and this was further increased by removal of sialic acid and N-linked glycans.	N-Acetylneuraminic Acid	149-160	complement C3	Homo sapiens	60-63
7921193-7	1994	Critical examination of available data point to only two consistent and unequivocal changes affecting goblet cell mucin in pathological processes: loss of O-acetyl substituents at sialic acid C4 and C7,8,9 and increased sialylation.	N-Acetylneuraminic Acid	180-191	LOC100508689	Homo sapiens	114-119
8203336-7	1994	Lp(a) levels in the 132 old old subjects showed positive correlations with sialic acid, fibrinogen, factor VII activity, and D-dimer levels.	N-Acetylneuraminic Acid	75-86	lipoprotein(a)	Homo sapiens	0-5
8185577-3	1994	A change in N-linked saccharide structure other than the neuraminidase-sensitive terminal sialic acid portion was found to be responsible for the molecular size change in CD45.	N-Acetylneuraminic Acid	90-101	protein tyrosine phosphatase receptor type C	Homo sapiens	171-175
8182079-3	1994	Expression of the COOH-terminal catalytic domain of Fuc-TVII showed an alpha 1,3-fucosyltransferase activity for a type II oligosaccharide with a terminal alpha 2,3-linked sialic acid among various acceptors, consistent with that in vivo acceptor specificity.	N-Acetylneuraminic Acid	172-183	fucosyltransferase 7	Homo sapiens	71-99
7513210-5	1994	PMN preincubated with mannose-6-P or N-acetylneuraminic acid (sialic acid), but not mannose or galactose-6-P, showed reduced adherence to ROS-treated HUVEC, suggesting that carbohydrate molecules were expressed on the latter and served as the ligand for the PMN L-selectin.	N-Acetylneuraminic Acid	62-73	selectin L	Homo sapiens	262-272
7513253-6	1994	The experimental data clearly show that only the embryonic NCAM molecule carrying the poly-alpha-(2,8)-linked N-acetylneuraminic acid moiety can be regarded as a specific serum marker for small cell lung cancer.	N-Acetylneuraminic Acid	110-133	neural cell adhesion molecule 1	Homo sapiens	59-63
7513210-5	1994	PMN preincubated with mannose-6-P or N-acetylneuraminic acid (sialic acid), but not mannose or galactose-6-P, showed reduced adherence to ROS-treated HUVEC, suggesting that carbohydrate molecules were expressed on the latter and served as the ligand for the PMN L-selectin.	N-Acetylneuraminic Acid	37-60	selectin L	Homo sapiens	262-272
8162602-2	1994	The melanoma-associated antigen, A32, was defined by a murine monoclonal antibody and was immunoprecipitated as a single 113 kDa integral membrane glycoprotein containing sialic acid and HNK-1 carbohydrate moieties.	N-Acetylneuraminic Acid	171-182	melanoma cell adhesion molecule	Homo sapiens	4-36
8144652-0	1994	The oligosaccharide binding specificities of CD22 beta, a sialic acid-specific lectin of B cells.	N-Acetylneuraminic Acid	58-69	CD22 molecule	Homo sapiens	45-49
8168943-6	1994	These results confirm that sialic acid and fucose present on cell surface macromolecules and especially glycoproteins are needed for the binding of SR to monocytes and for the release of TNF-alpha.	N-Acetylneuraminic Acid	27-38	tumor necrosis factor	Homo sapiens	187-196
8163475-1	1994	The B cell surface receptor CD22 binds several sialoglycoproteins containing sialic acid in alpha 2,6 linkage, on the surface of B and T lymphocytes.	N-Acetylneuraminic Acid	77-88	CD22 molecule	Homo sapiens	28-32
8166748-1	1994	The sialic acid-binding protein sarcolectin from human placenta specifically interacts with the lymphokine macrophage migration inhibitory factor, enabling its convenient purification and histochemical localization.	N-Acetylneuraminic Acid	4-15	keratin 7	Homo sapiens	32-43
8191218-4	1994	In the study presented here we demonstrate that human CD22Rg recognizes several murine cell-surface sialoglycoproteins, including CD45, containing sialic acid in alpha 2,6 linkage.	N-Acetylneuraminic Acid	147-158	CD22 molecule	Homo sapiens	54-58
8191218-4	1994	In the study presented here we demonstrate that human CD22Rg recognizes several murine cell-surface sialoglycoproteins, including CD45, containing sialic acid in alpha 2,6 linkage.	N-Acetylneuraminic Acid	147-158	protein tyrosine phosphatase, receptor type, C	Mus musculus	130-134
8191218-6	1994	Our results confirm and extend previous observations that CD22 is a sialic acid-binding lectin which interacts with CD45 and other glycoproteins capable of presenting alpha 2,6-linked sialic acid in a manner that promotes high affinity binding.	N-Acetylneuraminic Acid	68-79	CD22 molecule	Homo sapiens	58-62
8191218-6	1994	Our results confirm and extend previous observations that CD22 is a sialic acid-binding lectin which interacts with CD45 and other glycoproteins capable of presenting alpha 2,6-linked sialic acid in a manner that promotes high affinity binding.	N-Acetylneuraminic Acid	68-79	protein tyrosine phosphatase receptor type C	Homo sapiens	116-120
8191218-6	1994	Our results confirm and extend previous observations that CD22 is a sialic acid-binding lectin which interacts with CD45 and other glycoproteins capable of presenting alpha 2,6-linked sialic acid in a manner that promotes high affinity binding.	N-Acetylneuraminic Acid	184-195	CD22 molecule	Homo sapiens	58-62
8191218-6	1994	Our results confirm and extend previous observations that CD22 is a sialic acid-binding lectin which interacts with CD45 and other glycoproteins capable of presenting alpha 2,6-linked sialic acid in a manner that promotes high affinity binding.	N-Acetylneuraminic Acid	184-195	protein tyrosine phosphatase receptor type C	Homo sapiens	116-120
7512967-2	1994	In the present study, by use of an affinity column containing sialic acid-binding lectins from Maackia amurensis seeds, a mouse monoclonal IgG2b was successfully separated into three phenotypes, which are different in the degree of sialylation in the heavy chain.	N-Acetylneuraminic Acid	62-73	immunoglobulin heavy constant gamma 2B	Mus musculus	139-144
8150094-0	1994	Strong affinity of Maackia amurensis hemagglutinin (MAH) for sialic acid-containing Ser/Thr-linked carbohydrate chains of N-terminal octapeptides from human glycophorin A.	N-Acetylneuraminic Acid	61-72	glycophorin A (MNS blood group)	Homo sapiens	157-170
8070905-2	1994	Gc globulin attaches to sialic acid residues within the oligosaccharide chain of C5a des Arg to form a complex with potent chemotactic activity for human PMN.	N-Acetylneuraminic Acid	24-35	GC vitamin D binding protein	Homo sapiens	0-11
8070905-2	1994	Gc globulin attaches to sialic acid residues within the oligosaccharide chain of C5a des Arg to form a complex with potent chemotactic activity for human PMN.	N-Acetylneuraminic Acid	24-35	complement C5a receptor 1	Homo sapiens	81-84
8157712-10	1994	The difference in pI of each hCG isoform was attributable to the extent of sialylation; basic hCG isoforms contained less sialic acid by immunological detection using lectins.	N-Acetylneuraminic Acid	122-133	chorionic gonadotropin subunit beta 5	Homo sapiens	94-97
8132639-2	1994	We have proposed that cytidine monophospho-N-acetylneuraminic acid (CMP-NeuAc) hydroxylation is carried out by a multienzyme system involving CMP-NeuAc hydroxylase (the terminal enzyme of the system), cytochrome b5, and an NADH-dependent cytochrome b5-reducing factor (Kozutsumi, Y., Kawano, T., Yamakawa, T., and Suzuki, A.	N-Acetylneuraminic Acid	72-77	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Mus musculus	142-163
8144933-5	1994	Most of MCP-1"s microheterogeneity is due to variable amounts of sialic acid that are terminally attached to a constant number of O-linked oligosaccharide chains per molecule.	N-Acetylneuraminic Acid	65-76	chemokine (C-C motif) ligand 2	Mus musculus	8-13
8132639-2	1994	We have proposed that cytidine monophospho-N-acetylneuraminic acid (CMP-NeuAc) hydroxylation is carried out by a multienzyme system involving CMP-NeuAc hydroxylase (the terminal enzyme of the system), cytochrome b5, and an NADH-dependent cytochrome b5-reducing factor (Kozutsumi, Y., Kawano, T., Yamakawa, T., and Suzuki, A.	N-Acetylneuraminic Acid	72-77	cytochrome b5 type A (microsomal)	Mus musculus	201-214
8132639-2	1994	We have proposed that cytidine monophospho-N-acetylneuraminic acid (CMP-NeuAc) hydroxylation is carried out by a multienzyme system involving CMP-NeuAc hydroxylase (the terminal enzyme of the system), cytochrome b5, and an NADH-dependent cytochrome b5-reducing factor (Kozutsumi, Y., Kawano, T., Yamakawa, T., and Suzuki, A.	N-Acetylneuraminic Acid	72-77	cytochrome b5 type A (microsomal)	Mus musculus	238-251
8056746-0	1994	Reaction mechanism underlying CMP-N-acetylneuraminic acid hydroxylation in mouse liver: formation of a ternary complex of cytochrome b5, CMP-N-acetylneuraminic acid, and a hydroxylation enzyme.	N-Acetylneuraminic Acid	34-57	cytochrome b5 type A (microsomal)	Mus musculus	122-135
8038721-3	1994	The inhibitory activity of the acidic mucin decreased only 2-4-fold following removal of sialic acid, whereas the desulfation caused a complete loss of the inhibitory potential against both bacteria.	N-Acetylneuraminic Acid	89-100	LOC100508689	Homo sapiens	38-43
8038721-4	1994	Furthermore, the aggregating capacity of mucin-derived sulfated oligosaccharide was found to be 16-fold higher than that of the sialic acid containing oligosaccharide.	N-Acetylneuraminic Acid	128-139	LOC100508689	Homo sapiens	41-46
8056619-9	1994	Terminal N-acetylneuraminic acid(alpha 2-3)galactose(beta 1-3)N-acetylgalactosamine, N-acetylneuraminic acid(alpha 2-3)galactose(beta 1-4)N-acetylglucosamine and galactose(beta 1-4)N-acetylglucosamine sequences are contained in the oligosaccharide chains of gallbladder mucus glycoproteins.	N-Acetylneuraminic Acid	9-32	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	53-61
8056746-1	1994	We have proposed that CMP-N-acetylneuraminic acid (CMP-NeuAc) hydroxylation is mediated by an electron transport system consisting of cytochrome b5 (b5), b5 reducing factor(s), and CMP-NeuAc hydroxylase, all of which have been detected in the cytosolic fraction of mouse liver [Kozutsumi, Y., Kawano, T., Yamakawa, T., &amp; Suzuki, A.	N-Acetylneuraminic Acid	55-60	cytochrome b5 type A (microsomal)	Mus musculus	134-147
8056746-1	1994	We have proposed that CMP-N-acetylneuraminic acid (CMP-NeuAc) hydroxylation is mediated by an electron transport system consisting of cytochrome b5 (b5), b5 reducing factor(s), and CMP-NeuAc hydroxylase, all of which have been detected in the cytosolic fraction of mouse liver [Kozutsumi, Y., Kawano, T., Yamakawa, T., &amp; Suzuki, A.	N-Acetylneuraminic Acid	55-60	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Mus musculus	181-202
8056746-6	1994	These findings suggest that the binding of CMP-NeuAc to CMP-NeuAc hydroxylase changes the conformation of the enzyme so as to construct a recognition site for b5, followed by the formation of a ternary complex through this domain.	N-Acetylneuraminic Acid	47-52	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Mus musculus	56-77
7509359-9	1994	Both the UCHL1 and A6 epitopes were dependent on the presence of O-linked carbohydrates; and the UCHL1, but not the A6 epitope, was dependent on the presence of sialic acid.	N-Acetylneuraminic Acid	161-172	ubiquitin C-terminal hydrolase L1	Homo sapiens	97-102
8078523-11	1994	Thus, the glycophorin B-dependent, sialic acid-dependent invasion of trypsin-treated normal erythrocytes uses a different parasite ligand, indicating two or more sialic-dependent pathways for invasion.	N-Acetylneuraminic Acid	35-46	glycophorin B (MNS blood group)	Homo sapiens	10-23
8106417-7	1994	We have provisionally termed these clones SAP mutants, for sialic acid phenotype.	N-Acetylneuraminic Acid	59-70	SH2 domain containing 1A	Homo sapiens	42-45
7510413-1	1994	CZ-1 is a novel sialic acid-dependent epitope of the murine CD45RB molecule which is expressed on cells that proliferate when cultured in IL-2.	N-Acetylneuraminic Acid	16-27	immunoglobulin kappa variable 1-115	Mus musculus	0-4
7510413-1	1994	CZ-1 is a novel sialic acid-dependent epitope of the murine CD45RB molecule which is expressed on cells that proliferate when cultured in IL-2.	N-Acetylneuraminic Acid	16-27	interleukin 2	Mus musculus	138-142
8081256-5	1994	Treatment with neuraminidase removed a significant proportion of the wild-type virus binding activity, while both proteinase K and phosphatidylinositol-specific phospholipase C (PI-PLC) prevented binding of a non-hemagglutinating (non-HA), non-sialic acid binding mutant to 3201 cells.	N-Acetylneuraminic Acid	244-255	phospholipase C beta 1	Homo sapiens	131-176
8081256-5	1994	Treatment with neuraminidase removed a significant proportion of the wild-type virus binding activity, while both proteinase K and phosphatidylinositol-specific phospholipase C (PI-PLC) prevented binding of a non-hemagglutinating (non-HA), non-sialic acid binding mutant to 3201 cells.	N-Acetylneuraminic Acid	244-255	phospholipase C beta 1	Homo sapiens	178-184
8193553-4	1994	The O-glycans of human erythrocyte glycophorin A consist mainly of short oligosaccharides with one, two, or three sialic acid residues linked to a common disaccharide core, Gal beta 1-3GalNAc alpha 1-Ser/Thr, with the disialylated structure being the most abundant.	N-Acetylneuraminic Acid	114-125	glycophorin A (MNS blood group)	Homo sapiens	35-48
8283028-4	1994	Herein we demonstrate that the CD8 beta polypeptide changes physically during T cell maturation and activation by reversibly altering its sialic acid content.	N-Acetylneuraminic Acid	138-149	CD8 antigen, beta chain 1	Mus musculus	31-39
7506734-0	1994	Differences between human eosinophils and neutrophils in the function and expression of sialic acid-containing counterligands for E-selectin.	N-Acetylneuraminic Acid	88-99	selectin E	Homo sapiens	130-140
8187208-7	1994	The presence of sialic acid at millimolar concentrations in the medium inhibits much of the Lp[a]-enhanced binding of 125I-LDL to the cells.	N-Acetylneuraminic Acid	16-27	lipoprotein(a)	Homo sapiens	92-96
8154849-2	1994	Sialic acid was added to ALP sugar moieties by alpha 2,3- or 2,6-sialyltransferase treatment of the asialo-form ALP (neuraminidase-treated ALP).	N-Acetylneuraminic Acid	0-11	ATHS	Homo sapiens	25-28
8154849-2	1994	Sialic acid was added to ALP sugar moieties by alpha 2,3- or 2,6-sialyltransferase treatment of the asialo-form ALP (neuraminidase-treated ALP).	N-Acetylneuraminic Acid	0-11	ATHS	Homo sapiens	112-115
8154849-2	1994	Sialic acid was added to ALP sugar moieties by alpha 2,3- or 2,6-sialyltransferase treatment of the asialo-form ALP (neuraminidase-treated ALP).	N-Acetylneuraminic Acid	0-11	neuraminidase 1	Homo sapiens	117-130
8154849-2	1994	Sialic acid was added to ALP sugar moieties by alpha 2,3- or 2,6-sialyltransferase treatment of the asialo-form ALP (neuraminidase-treated ALP).	N-Acetylneuraminic Acid	0-11	ATHS	Homo sapiens	112-115
8154849-10	1994	The difference between liver and bone ALP molecules may be due not only to their manner of sialic acid linkage but also to the attachment of the O-linked sugar moiety.	N-Acetylneuraminic Acid	91-102	ATHS	Homo sapiens	38-41
8187210-7	1994	Desialylated (sialic acid-poor) Lp(a), but not sialylated lipoproteins, were capable of increasing the intracellular content of total cholesterol.	N-Acetylneuraminic Acid	14-25	lipoprotein(a)	Homo sapiens	32-37
7840430-0	1994	[Multicenter study of sialic acid deficient transferrin determined by two chromatographic techniques].	N-Acetylneuraminic Acid	22-33	transferrin	Homo sapiens	44-55
8032275-2	1994	Inactivation of receptors by neuraminidase treatment and restoration of receptors by enzymatic resialylation of asialo-cells is described as a method to determine (i) the type of sialic acid that is recognized; (ii) the linkage specificity of the viral binding activity; (iii) the minimal amount of sialic acid required for virus attachment.	N-Acetylneuraminic Acid	179-190	neuraminidase 1	Homo sapiens	29-42
8032275-2	1994	Inactivation of receptors by neuraminidase treatment and restoration of receptors by enzymatic resialylation of asialo-cells is described as a method to determine (i) the type of sialic acid that is recognized; (ii) the linkage specificity of the viral binding activity; (iii) the minimal amount of sialic acid required for virus attachment.	N-Acetylneuraminic Acid	299-310	neuraminidase 1	Homo sapiens	29-42
8261462-5	1994	Several percentages of the Lewis X antigenic determinant and fucosylated mannose core were linked to them, and their sialic acid residues were linked to nonreducing terminal galactose residues at the C-3 and C-6 positions.	N-Acetylneuraminic Acid	117-128	complement C3	Homo sapiens	200-203
8261462-5	1994	Several percentages of the Lewis X antigenic determinant and fucosylated mannose core were linked to them, and their sialic acid residues were linked to nonreducing terminal galactose residues at the C-3 and C-6 positions.	N-Acetylneuraminic Acid	117-128	complement C6	Homo sapiens	208-211
8187210-4	1994	The sialic acid content of patients" Lp(a) was 2.5-fold lower as compared with that of healthy subjects" Lp(a).	N-Acetylneuraminic Acid	4-15	lipoprotein(a)	Homo sapiens	37-42
8165031-10	1994	That the offending plasma constituent was a sialomucin was suggested by mucin stains of the tumor and peripheral blood, a plasma sialic acid level 10 x normal and a substantial fall in viscosity after in vitro treatment of plasma with neuraminidase.	N-Acetylneuraminic Acid	129-140	LOC100508689	Homo sapiens	49-54
7513190-0	1994	N-acetylneuraminic acid estimation in human serum by neuraminidase and resorcinol/ferric(III) chloride reagent in hydrochloric solution.	N-Acetylneuraminic Acid	0-23	neuraminidase 1	Homo sapiens	53-66
7506656-1	1993	The structures of N-linked oligosaccharides, especially the distribution of sialic acid species, present on porcine plasma vitronectin were elucidated.	N-Acetylneuraminic Acid	76-87	vitronectin	Homo sapiens	123-134
7871640-6	1994	The main difference was the reduction in sialic acid in UAP isolated from the urine of stone formers.	N-Acetylneuraminic Acid	41-52	alpha-1-microglobulin/bikunin precursor	Homo sapiens	56-59
8138529-6	1993	Transferrin isoforms containing 4, 2, and 0 sialic acid residues, S4, S2, and S0, were separated by Mono Q anion exchange column chromatography from serum of a patient with the CDG syndrome.	N-Acetylneuraminic Acid	44-55	transferrin	Homo sapiens	0-11
7505053-3	1993	MAdCAM-1 isolated from mesenteric lymph nodes, but not from cultured endothelioma cells, bears N-glycanase-resistant sialic acid-containing carbohydrate which supports adhesion of L-selectin-transfected lymphoid cells under shear.	N-Acetylneuraminic Acid	117-128	mucosal vascular addressin cell adhesion molecule 1	Homo sapiens	0-8
7505053-3	1993	MAdCAM-1 isolated from mesenteric lymph nodes, but not from cultured endothelioma cells, bears N-glycanase-resistant sialic acid-containing carbohydrate which supports adhesion of L-selectin-transfected lymphoid cells under shear.	N-Acetylneuraminic Acid	117-128	selectin L	Homo sapiens	180-190
8292261-9	1993	This sensitive and automated assay concept with the covalently immobilized heparin-binding protein is supposed to be adaptable to other groups of lectins with specificity to anionic sugars like sialic acid-binding proteins.	N-Acetylneuraminic Acid	194-205	azurocidin 1	Homo sapiens	75-98
8254036-1	1993	Osteopontin is a phosphorylated, sialic acid-rich, noncollagenous bone matrix protein containing the Arg-Gly-Asp-Ser amino acid sequence responsible for cell adhesion.	N-Acetylneuraminic Acid	33-44	secreted phosphoprotein 1	Homo sapiens	0-11
7507325-4	1993	Total sialic acid concentration correlated significantly with apolipoprotein B (r = 0.48), number of cigarettes smoked daily (r = 0.32), and leisure time physical activity (r = -0.23) after adjustment for age and other cardiovascular risk markers.	N-Acetylneuraminic Acid	6-17	apolipoprotein B	Homo sapiens	62-78
8286583-5	1993	CA12/BC7 antigen, detected in plasma membrane fraction, was a glycoprotein with sialic acid residues and had affinity with WGA lectin.	N-Acetylneuraminic Acid	80-91	carbonic anhydrase 12	Mus musculus	0-4
8161881-4	1993	The main binding epitope for the MAb was, therefore, the terminal N-acetylneuraminic acid 2-3 Gal linked by a beta 1-1 bond to the ceramide, or a beta 1-4 bond to glucose or glucosamine.	N-Acetylneuraminic Acid	66-89	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	110-118
8229005-2	1993	We found that exogenously administered GM3(NeuAc) promoted PKA activity in cultured brain microvascular endothelial cells (BMECs).	N-Acetylneuraminic Acid	43-48	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	59-62
8144855-3	1993	Endoglycosidase treatment and carbohydrate content of PRL was found to be consistent with N-linked oligosaccharides of mannose-rich structure and complex units terminated in sialic acid.	N-Acetylneuraminic Acid	174-185	prolactin	Homo sapiens	54-57
8226797-7	1993	PECAM-1 molecules on tumor cells appear to bear terminal carbohydrate moieties (i.e. sialic acid residues) different from those on platelets, since neuraminidase treatment of tumor cells, unlike platelets, did not result in a mobility shift.	N-Acetylneuraminic Acid	85-96	platelet and endothelial cell adhesion molecule 1	Homo sapiens	0-7
8411349-0	1993	Relative affinity of the human parainfluenza virus type 3 hemagglutinin-neuraminidase for sialic acid correlates with virus-induced fusion activity.	N-Acetylneuraminic Acid	90-101	hemagglutinin-neuraminidase	Human respirovirus 3	58-85
8411349-3	1993	Sialic acid is the receptor for the human parainfluenza virus type 3 (HPF3) hemagglutinin-neuraminidase (HN) glycoprotein, the molecule responsible for binding of the virus to cell surfaces.	N-Acetylneuraminic Acid	0-11	zinc finger protein 17	Homo sapiens	70-74
8411349-3	1993	Sialic acid is the receptor for the human parainfluenza virus type 3 (HPF3) hemagglutinin-neuraminidase (HN) glycoprotein, the molecule responsible for binding of the virus to cell surfaces.	N-Acetylneuraminic Acid	0-11	hemagglutinin-neuraminidase	Human respirovirus 3	76-103
8411349-3	1993	Sialic acid is the receptor for the human parainfluenza virus type 3 (HPF3) hemagglutinin-neuraminidase (HN) glycoprotein, the molecule responsible for binding of the virus to cell surfaces.	N-Acetylneuraminic Acid	0-11	hemagglutinin-neuraminidase	Human respirovirus 3	105-107
8248941-6	1993	(3) The rotational motion of spin-labeled sialic acid, 70% of which is on the major transmembrane sialoglycoprotein (glycophorin A or PAS 1), was not affected by MAA treatment.	N-Acetylneuraminic Acid	42-53	glycophorin A (MNS blood group)	Homo sapiens	117-130
8407906-3	1993	Pg activation by u-PA on the surface of RA synovial fibroblasts induces a significant rise in cytosolic free Ca2+ concentration ([Ca2+]i) within 90 s. Pg kringle 4 and the alpha 2,3-linked sialic acid in the carbohydrate chain bound to Thr245 are involved in mediating the increases in [Ca2+]i.	N-Acetylneuraminic Acid	189-200	plasminogen activator, urokinase	Homo sapiens	17-21
8252537-2	1993	By this procedure, both the fatty acids residue and the N-acetyl group of sialic acid were removed to give mono-N-acetyl-lysoGM1 (C18 and C20); the additional loss of the N-acetyl group of the acetylgalactosamine moiety gave de-N-acetyl-lysoGM1 (C18 and C20) with three free amino groups.	N-Acetylneuraminic Acid	74-85	Bardet-Biedl syndrome 9	Homo sapiens	130-133
8252537-2	1993	By this procedure, both the fatty acids residue and the N-acetyl group of sialic acid were removed to give mono-N-acetyl-lysoGM1 (C18 and C20); the additional loss of the N-acetyl group of the acetylgalactosamine moiety gave de-N-acetyl-lysoGM1 (C18 and C20) with three free amino groups.	N-Acetylneuraminic Acid	74-85	Bardet-Biedl syndrome 9	Homo sapiens	246-249
8286854-5	1993	The deficiency of sialic acid, in particular, results in a cathodal shift and hence the presence of abnormal isoforms of transferrin with higher isoelectric points than normal.	N-Acetylneuraminic Acid	18-29	transferrin	Homo sapiens	121-132
8403395-3	1993	Transferrin isoforms deficient in sialic acid, with pIs 5.7 and 5.9, can easily be separated and quantitated as a percentage of the total transferrin.	N-Acetylneuraminic Acid	34-45	transferrin	Homo sapiens	0-11
8403395-3	1993	Transferrin isoforms deficient in sialic acid, with pIs 5.7 and 5.9, can easily be separated and quantitated as a percentage of the total transferrin.	N-Acetylneuraminic Acid	34-45	transferrin	Homo sapiens	138-149
8407976-5	1993	During recycling, sialic acid residues are added to the premature form of episialin resulting in complete maturation of the molecule.	N-Acetylneuraminic Acid	18-29	mucin 1, cell surface associated	Homo sapiens	74-83
7691607-2	1993	Here we show that mAb CZ-1 defines a sialic acid-dependent epitope associated with a subpopulation of CD45 molecules.	N-Acetylneuraminic Acid	37-48	immunoglobulin kappa variable 1-115	Mus musculus	22-26
7691607-2	1993	Here we show that mAb CZ-1 defines a sialic acid-dependent epitope associated with a subpopulation of CD45 molecules.	N-Acetylneuraminic Acid	37-48	protein tyrosine phosphatase, receptor type, C	Mus musculus	102-106
7691607-3	1993	This conclusion is based on the ability to block binding of mAb CZ-1 by sialic acid, neuramin-lactose, neuraminidase, and mAb to CD45RB, and by expression of the epitope on transfected psi 2 cells expressing exon B of CD45.	N-Acetylneuraminic Acid	72-83	immunoglobulin kappa variable 1-115	Mus musculus	64-68
8360173-5	1993	HMW-AR1 and HMW-AR2 were found to possess complex or hybrid type N-linked oligosaccharide structures that contained sialic acid.	N-Acetylneuraminic Acid	116-127	cilia and flagella associated protein 97	Homo sapiens	0-3
8107692-1	1993	A group of sialic acid binding (SAS) agglutinins has been isolated from the rat uteri at different stages [Proestrus (P), estrus (E) and diestrus (D)] of estrous cycle.	N-Acetylneuraminic Acid	11-22	tetraspanin 31	Rattus norvegicus	32-35
8263678-11	1993	Removal of sialic acid from the IMR-32 NB cell surface using Clostridium neuraminidase (2.7 mg/mL) inhibited 75% of NDV plaque formation.	N-Acetylneuraminic Acid	11-22	neuraminidase 1	Homo sapiens	73-86
8069621-1	1993	BACKGROUND: Neuraminidase, one of the two surface glycoproteins of influenza virus, cleaves terminal sialic acid residues from glycolipids or glycoproteins.	N-Acetylneuraminic Acid	101-112	neuraminidase 1	Homo sapiens	12-25
8069621-3	1993	RESULTS: We have determined the crystal structure at 1.8 A resolution of two complexes of influenza B/Beijing neuraminidase containing either the reaction product, sialic acid, or the transition state analogue inhibitor, 2,3-dehydro-2-deoxy-N-acetylneuraminic acid (DANA).	N-Acetylneuraminic Acid	164-175	neuraminidase 1	Homo sapiens	110-123
8360173-5	1993	HMW-AR1 and HMW-AR2 were found to possess complex or hybrid type N-linked oligosaccharide structures that contained sialic acid.	N-Acetylneuraminic Acid	116-127	transcription factor 20	Homo sapiens	4-7
8360173-5	1993	HMW-AR1 and HMW-AR2 were found to possess complex or hybrid type N-linked oligosaccharide structures that contained sialic acid.	N-Acetylneuraminic Acid	116-127	cilia and flagella associated protein 97	Homo sapiens	12-15
7505629-3	1993	In contrast, following neuraminidase pretreatment of both types of material, the fucosylated type 2 chain (Le(x)) became detectable on Langerhans cells, indicating that sialic acid is the terminal residue of this sequence.	N-Acetylneuraminic Acid	169-180	neuraminidase 1	Homo sapiens	23-36
8239497-8	1993	In spite of this different reactivity with Mabs, analysis by proton nuclear magnetic resonance (1H NMR) proved that carbohydrate structure of K-1 and H-2 were the same: NeuAc alpha 2--&gt;3Ga1 beta 1--&gt;4 [Fuc alpha 1--&gt;3] G1cNAc beta 1--&gt;3 Ga1 beta 1--&gt;4G1c beta 1--&gt;1Cer.	N-Acetylneuraminic Acid	169-174	keratin 1	Homo sapiens	142-153
7694599-4	1993	The Ft-CML reactivity of the PAA-positive isolates was inhibited by bovine submaxillary mucin, transferrin, fetuin, orosomucoid, vitronectin and lactoferrin in a manner which suggested that the isolates contain a lectin recognizing the alpha(2-6) linkage of terminal sialic acid.	N-Acetylneuraminic Acid	267-278	lactotransferrin	Bos taurus	145-156
8370046-1	1993	A stereocontrolled, facile total synthesis of ganglioside GD3 is described as an example of a proposed systematic approach to the preparation of gangliosides containing an alpha-sialyl-(2--&gt;8)-sialic acid unit alpha-glycosidically linked to O-3 of a D-galactose residue in their oligosaccharide chains.	N-Acetylneuraminic Acid	196-207	GRDX	Homo sapiens	58-61
7689955-11	1993	Nicking of the putative amphipathic helix loop, hCG beta 38-57, apparently renders the hormone significantly less hydrophobic despite the equal molar content of sialic acid.	N-Acetylneuraminic Acid	161-172	chorionic gonadotropin subunit beta 5	Homo sapiens	48-51
7688790-6	1993	Neuraminidase treatment of the gamma/delta T cells or addition of ethylenediaminetetraacetic acid (EDTA) to the assay abrogates binding, demonstrating the importance of sialic acid and divalent cations, which is consistent with other E-selectin-mediated adhesion events.	N-Acetylneuraminic Acid	169-180	neuraminidase 1	Bos taurus	0-13
8400551-5	1993	Unlike bovine rhodopsin, however, a sizable fraction of the total glycans of frog rhodopsin also contained sialic acid (NeuAc), with the sialylated oligosaccharides being present exclusively at the Asn2 site.	N-Acetylneuraminic Acid	107-118	rhodopsin	Bos taurus	82-91
8174952-8	1993	As sialic acid may be considered an index of mucus glycoprotein degradation, it seems that gastrin stimulation of gastric epithelial cells results in a concomittant secretion of platelet activating factor precursors, acid, and pepsin irrespective of mucus glycoprotein degradation.	N-Acetylneuraminic Acid	3-14	gastrin	Homo sapiens	91-98
7691460-9	1993	There was a significant correlation between serum total sialic acid and serum alpha 1-antichymotrypsin, alpha 1-acid glycoprotein and haptoglobin (Spearman correlation coefficients 0.74, 0.50 and 0.76, respectively) in the normal subjects, and there was a significant correlation between serum total sialic acid and serum alpha 1-antichymotrypsin and alpha 1-acid glycoprotein (Spearman correlation coefficients 0.72 and 0.84, respectively) in the hypertriglyceridaemic patients.	N-Acetylneuraminic Acid	56-67	haptoglobin	Homo sapiens	134-145
7691460-9	1993	There was a significant correlation between serum total sialic acid and serum alpha 1-antichymotrypsin, alpha 1-acid glycoprotein and haptoglobin (Spearman correlation coefficients 0.74, 0.50 and 0.76, respectively) in the normal subjects, and there was a significant correlation between serum total sialic acid and serum alpha 1-antichymotrypsin and alpha 1-acid glycoprotein (Spearman correlation coefficients 0.72 and 0.84, respectively) in the hypertriglyceridaemic patients.	N-Acetylneuraminic Acid	300-311	haptoglobin	Homo sapiens	134-145
8400551-0	1993	Identification and oligosaccharide structure analysis of rhodopsin glycoforms containing galactose and sialic acid.	N-Acetylneuraminic Acid	103-114	rhodopsin	Homo sapiens	57-66
8400551-5	1993	Unlike bovine rhodopsin, however, a sizable fraction of the total glycans of frog rhodopsin also contained sialic acid (NeuAc), with the sialylated oligosaccharides being present exclusively at the Asn2 site.	N-Acetylneuraminic Acid	120-125	rhodopsin	Bos taurus	82-91
8335684-3	1993	Transport to the plasma membrane was measured using neuraminidase to remove sialic acid residues on surface HLA molecules.	N-Acetylneuraminic Acid	76-87	neuraminidase 1	Homo sapiens	52-65
8331283-7	1993	Neuraminidase completely digested these anionic sites, which indicated that the anionic charge of the apocrine lumen was due to sialic acid.	N-Acetylneuraminic Acid	128-139	neuraminidase 1	Homo sapiens	0-13
8212857-4	1993	Extracts of human bronchial mucin, which is known to contain sialic acid primarily in the SA alpha 2,3Gal linkage, was a potent inhibitor of the binding of the receptor variant strain to trachea sections, while the binding of the parent strain was unaffected by the presence of mucin.	N-Acetylneuraminic Acid	61-72	LOC100508689	Homo sapiens	28-33
8362199-5	1993	The proportional amount of sialic acid, used as an indicator of mucin concentration, was higher in subjects with BMS than in their controls.	N-Acetylneuraminic Acid	27-38	LOC100508689	Homo sapiens	64-69
8212857-4	1993	Extracts of human bronchial mucin, which is known to contain sialic acid primarily in the SA alpha 2,3Gal linkage, was a potent inhibitor of the binding of the receptor variant strain to trachea sections, while the binding of the parent strain was unaffected by the presence of mucin.	N-Acetylneuraminic Acid	61-72	LOC100508689	Homo sapiens	278-283
8314763-1	1993	Apparent kinetic parameters have been measured for the transfer of N-acetyl-D-neuraminic acid (Neu5Ac) from CMP-Neu5Ac to analogues of the Gal(beta 1-4)GlcNAc (type II) and Gal(beta 1-3)GlcNAc (type I) substrates by the rat liver Gal(beta 1-4)GlcNAc alpha 2,6-sialyltransferase and the Gal(beta 1-3/4)GlcNAc alpha 2,3-sialyltransferase.	N-Acetylneuraminic Acid	67-93	galanin and GMAP prepropeptide	Rattus norvegicus	230-277
8314763-1	1993	Apparent kinetic parameters have been measured for the transfer of N-acetyl-D-neuraminic acid (Neu5Ac) from CMP-Neu5Ac to analogues of the Gal(beta 1-4)GlcNAc (type II) and Gal(beta 1-3)GlcNAc (type I) substrates by the rat liver Gal(beta 1-4)GlcNAc alpha 2,6-sialyltransferase and the Gal(beta 1-3/4)GlcNAc alpha 2,3-sialyltransferase.	N-Acetylneuraminic Acid	67-93	galanin and GMAP prepropeptide	Rattus norvegicus	286-335
8314763-1	1993	Apparent kinetic parameters have been measured for the transfer of N-acetyl-D-neuraminic acid (Neu5Ac) from CMP-Neu5Ac to analogues of the Gal(beta 1-4)GlcNAc (type II) and Gal(beta 1-3)GlcNAc (type I) substrates by the rat liver Gal(beta 1-4)GlcNAc alpha 2,6-sialyltransferase and the Gal(beta 1-3/4)GlcNAc alpha 2,3-sialyltransferase.	N-Acetylneuraminic Acid	95-101	galanin and GMAP prepropeptide	Rattus norvegicus	230-277
8314763-1	1993	Apparent kinetic parameters have been measured for the transfer of N-acetyl-D-neuraminic acid (Neu5Ac) from CMP-Neu5Ac to analogues of the Gal(beta 1-4)GlcNAc (type II) and Gal(beta 1-3)GlcNAc (type I) substrates by the rat liver Gal(beta 1-4)GlcNAc alpha 2,6-sialyltransferase and the Gal(beta 1-3/4)GlcNAc alpha 2,3-sialyltransferase.	N-Acetylneuraminic Acid	95-101	galanin and GMAP prepropeptide	Rattus norvegicus	286-335
7691334-3	1993	The changes in hydrophobicity are related to the cell total lipid and cholesterol content while the changes in the charge are related to the sialic acid released by neuraminidase.	N-Acetylneuraminic Acid	141-152	neuraminidase 1	Homo sapiens	165-178
8318834-5	1993	Neuraminidase treatment of gangliosides with alpha 2-3 substituted sialic acid is necessary prior to immunostaining whereas alpha 2-6 sialylated gangliosides can be detected without enzyme treatment.	N-Acetylneuraminic Acid	67-78	neuraminidase 1	Homo sapiens	0-13
8352935-5	1993	The ESA152 epitope includes the sialic acid termini of N-linked oligosaccharides, as shown by its sensitivity to neuraminidase and endoglycosidase F. The ESA152 antigen is a highly hydrophobic integral membrane protein that resists aqueous extraction, partitions into the detergent phase of Triton-X-114, and solubilizes in chloroform-methanol mixtures.	N-Acetylneuraminic Acid	32-43	neuraminidase 1	Homo sapiens	113-126
8333587-2	1993	Chronic ethanol alters the normal microheterogeneity pattern of transferrin as a consequence of changes in the sialic acid content.	N-Acetylneuraminic Acid	111-122	transferrin	Rattus norvegicus	64-75
8333587-3	1993	However the underlying basis of this change in sialic acid contents of transferrin in alcohol abuse remains unclear.	N-Acetylneuraminic Acid	47-58	transferrin	Rattus norvegicus	71-82
8364416-6	1993	Preliminary carbohydrate analysis suggested that p37 is a glycoprotein and contained about 11% neutral sugars and 6.6% sialic acid.	N-Acetylneuraminic Acid	119-130	nucleoporin 37	Homo sapiens	49-52
8486686-12	1993	Incubations with CMP-Neu5Ac and acetyl-CoA corroborated the results with brefeldin A, co-localizing ganglioside O-acetyltransferase activity in compartments where GD3 biosynthesis takes place.	N-Acetylneuraminic Acid	21-27	CAS1 domain containing 1	Homo sapiens	112-131
8486686-12	1993	Incubations with CMP-Neu5Ac and acetyl-CoA corroborated the results with brefeldin A, co-localizing ganglioside O-acetyltransferase activity in compartments where GD3 biosynthesis takes place.	N-Acetylneuraminic Acid	21-27	GRDX	Homo sapiens	163-166
8330405-2	1993	We report a case of an allelic (polypeptide) variant of transferrin with mobility similar to that of the beta 2 (sialic acid-depleted) transferrin found in cerebrospinal fluid (CSF) and a few other body fluids.	N-Acetylneuraminic Acid	113-124	transferrin	Homo sapiens	56-67
8330405-2	1993	We report a case of an allelic (polypeptide) variant of transferrin with mobility similar to that of the beta 2 (sialic acid-depleted) transferrin found in cerebrospinal fluid (CSF) and a few other body fluids.	N-Acetylneuraminic Acid	113-124	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	105-111
8330405-2	1993	We report a case of an allelic (polypeptide) variant of transferrin with mobility similar to that of the beta 2 (sialic acid-depleted) transferrin found in cerebrospinal fluid (CSF) and a few other body fluids.	N-Acetylneuraminic Acid	113-124	transferrin	Homo sapiens	135-146
8219921-3	1993	The assay was based on release of sialic acid from glycoconjugates by neuraminidase, cleavage of sialic acid by N-acetyl neuraminic acid aldolase to pyruvate, and then oxidation of pyruvate to hydrogen peroxide by pyruvate oxidase.	N-Acetylneuraminic Acid	34-45	neuraminidase 1	Homo sapiens	70-83
7685769-2	1993	The carbohydrate compositional analysis indicated that G-CSF molecule contains sialic acid, galactose and galactosamine.	N-Acetylneuraminic Acid	79-90	colony stimulating factor 3	Homo sapiens	55-60
8099567-5	1993	Two reference CD43 antibodies (MEM-59 and DF-T1), both binding the same or closely related sialic acid-dependent epitope as mAb 1.C1, are also capable of inducing cell clump formation.	N-Acetylneuraminic Acid	91-102	sialophorin	Homo sapiens	14-18
8463234-0	1993	CD22, a B cell-specific immunoglobulin superfamily member, is a sialic acid-binding lectin.	N-Acetylneuraminic Acid	64-75	CD22 molecule	Homo sapiens	0-4
8463234-5	1993	CD22Rg is observed to bind specifically to a 115-kDa sialoglycoprotein in COS cells transfected with an alpha-2,6-sialyltransferase cDNA, but not in COS cells transfected with unrelated cDNA clones, indicating that at least some CD22-mediated interactions require presentation of sialic acid in an alpha-2,6 linkage by CD22 ligands.	N-Acetylneuraminic Acid	280-291	CD22 molecule	Homo sapiens	0-4
8463234-8	1993	Taken together, these observations indicate that CD22 is a sialic acid-binding lectin and may define a novel functional subset of immunoglobulin superfamily adhesion molecules.	N-Acetylneuraminic Acid	59-70	CD22 molecule	Homo sapiens	49-53
7682218-4	1993	Binding of this protein was strictly Ca(2+)-dependent, was blocked by a cell adhesion-blocking mAb against mouse E-selectin, and required the presence of sialic acid on the 150-kD ligand.	N-Acetylneuraminic Acid	154-165	selectin, endothelial cell	Mus musculus	113-123
8496389-9	1993	These findings were compatible with specificity of MMM-17 for sialomucins O-acetylated at the C-7 or C-8 positions on the sialic acid.	N-Acetylneuraminic Acid	122-133	homeobox C8	Homo sapiens	101-104
8499763-2	1993	Because most of the information on the structure-function relation of hCG as a thyroid stimulator has been derived from in vitro experiments, the present studies were undertaken to assess the role of its sialic acid residues in the expression of its thyrotropic activity in vivo.	N-Acetylneuraminic Acid	204-215	chorionic gonadotropin subunit beta 5	Homo sapiens	70-73
7679675-2	1993	Previous work has implicated the carbohydrate sialyl Lewis(x) (sLe(x); sialic acid alpha 2-3 galactose beta 1-4 [Fucose alpha 1-3] N-acetyl glucosamine) as a component of the ligand recognized by E- and P-selectin.	N-Acetylneuraminic Acid	71-82	selectin P	Homo sapiens	203-213
8428982-6	1993	In accordance with this, selective removal of sialic acid residues on the activation peptide of factor X by neuraminidase also results in a drastic reduction of activation of the zymogen by these complexes.	N-Acetylneuraminic Acid	46-57	neuraminidase 1	Homo sapiens	108-121
8448385-1	1993	Sialic acid-binding lectin (SBL) isolated from Rana catesbeiana eggs is a basic protein which agglutinates a large variety of tumour cells and has an amino acid sequence homologous to that of human angiogenin and pancreatic ribonuclease (RNase).	N-Acetylneuraminic Acid	0-11	angiogenin	Homo sapiens	198-208
8429037-2	1993	Both the cell surface membrane and the thyroglobulin secreted by cells grown in the presence of this hormone exhibit a marked decrease in the level of alpha 2,6-bound sialic acid with little or no change in the number of alpha 2,3-sialic acid residues.	N-Acetylneuraminic Acid	167-178	thyroglobulin	Rattus norvegicus	39-52
8358227-4	1993	Glycoproteins like fetuin and saponified bovine submandibular gland mucin, most of them having alpha(2-6) linked sialic acids, are preferred substrates, while sialic acids from gangliosides, sialyllactoses, or the alpha(2-8) linked sialic acid polymer (colominic acid) are hydrolysed at lower rates.	N-Acetylneuraminic Acid	113-124	mucin 1, cell surface associated	Bos taurus	68-73
8358221-1	1993	The hydroxylation of CMP-NeuAc has been demonstrated to be carried out by several factors including the soluble form of cytochrome b5.	N-Acetylneuraminic Acid	25-30	cytochrome b5 type A (microsomal)	Mus musculus	120-133
8358229-5	1993	Metabolically labelled mucin isolated from UC patients contained less sulfate and had lower sialic acid O-acetylation compared with normal mucin.	N-Acetylneuraminic Acid	92-103	LOC100508689	Homo sapiens	23-28
8257298-9	1993	The most likely explanation of the observed phenomenon seems to be an inefficient removal of sialic acid residues from the avian virus hemagglutinin by the human virus N1 neuraminidase.	N-Acetylneuraminic Acid	93-104	neuraminidase 1	Homo sapiens	171-184
8383360-3	1993	Furthermore, neuraminidase-labile sialic acid was also elevated in the more electrophoretically mobile platelet subpopulation (29.1 +/- 6.0 nmol/10(9) platelets vs. 21.8 +/- 10.4 nmol/10(9) platelets, p &lt; 0.05 paired Student"s t-test).	N-Acetylneuraminic Acid	34-45	neuraminidase 1	Homo sapiens	13-26
8358221-4	1993	The other fraction, which flowed through the column, was assumed to contain the terminal enzyme which accepts electrons from cytochrome b5, activates oxygen, and catalyses the hydroxylation of CMP-NeuAc.	N-Acetylneuraminic Acid	197-202	cytochrome b5 type A (microsomal)	Mus musculus	125-138
7681068-5	1993	This method can determine 0.08-10 nmol of sialic acid accurately within 12 min and was successfully applied to bovine vitronectin.	N-Acetylneuraminic Acid	42-53	vitronectin	Bos taurus	118-129
8432340-2	1993	This suggests that the sialic acid content on the terminus of N-glycoside linked carbohydrate chains of the IPM increases between P14 and P16.	N-Acetylneuraminic Acid	23-34	SUB1 regulator of transcription	Rattus norvegicus	130-133
7670541-11	1993	Previously unreported resistance to glycosylphosphatidylinositol-specific phospholipase D has been observed both to glycosylphosphatidylinositol-specific phospholipase D has been observed both to 1G7-Ag and 10D8-Ag, the GPI-anchored mucynlike protein which is acceptor of sialic acid in metacyclic forms.	N-Acetylneuraminic Acid	272-283	glucose-6-phosphate isomerase	Homo sapiens	220-223
8448983-9	1993	Treatment of selected plasmas with neuraminidase demonstrated that the microheterogeneity observed in the PIA, PIB, PIC and PID proteins was attributable to sialic acid additions.	N-Acetylneuraminic Acid	157-168	neuraminidase 1	Homo sapiens	35-48
8448983-9	1993	Treatment of selected plasmas with neuraminidase demonstrated that the microheterogeneity observed in the PIA, PIB, PIC and PID proteins was attributable to sialic acid additions.	N-Acetylneuraminic Acid	157-168	RPTOR independent companion of MTOR complex 2	Homo sapiens	106-109
8448983-9	1993	Treatment of selected plasmas with neuraminidase demonstrated that the microheterogeneity observed in the PIA, PIB, PIC and PID proteins was attributable to sialic acid additions.	N-Acetylneuraminic Acid	157-168	metastasis associated 1 family member 2	Homo sapiens	124-127
8432340-2	1993	This suggests that the sialic acid content on the terminus of N-glycoside linked carbohydrate chains of the IPM increases between P14 and P16.	N-Acetylneuraminic Acid	23-34	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	138-141
8441332-4	1993	Viral infections may decrease M2 receptor function by inducing inflammation or via direct damage to the receptors as a result of cleavage of sialic acid residues by viral neuraminidase.	N-Acetylneuraminic Acid	141-152	neuraminidase 1	Homo sapiens	171-184
8418057-3	1993	Binding of pertussis toxin to these vesicles decreased upon treatment of the vesicles with neuraminidase, suggesting that sialic acid residues are important for efficient binding of the toxin to GD1a.	N-Acetylneuraminic Acid	122-133	neuraminidase 1	Homo sapiens	91-104
8417168-4	1993	The highest concentrations (200-1,000 nmol of sialic acid/g wet weight) of GD3 was found in specimens of macroscopically pure tumor, where the proportion of GD3 was, at the most, 78% (range, 11-78%) of the total ganglioside sialic acid compared with &lt; 10% in normal brain tissue.	N-Acetylneuraminic Acid	46-57	GRDX	Homo sapiens	75-78
8417168-4	1993	The highest concentrations (200-1,000 nmol of sialic acid/g wet weight) of GD3 was found in specimens of macroscopically pure tumor, where the proportion of GD3 was, at the most, 78% (range, 11-78%) of the total ganglioside sialic acid compared with &lt; 10% in normal brain tissue.	N-Acetylneuraminic Acid	224-235	GRDX	Homo sapiens	75-78
8417168-5	1993	The proportion of the total ganglioside sialic acid made up by GD3 was also elevated in the periphery of the tumor and in the same region in the opposite hemisphere, where no tumor cells were detected.	N-Acetylneuraminic Acid	40-51	GRDX	Homo sapiens	63-66
8417168-6	1993	In four of eight brain metastases of various carcinomas, GD3 was &gt; 10% of the total ganglioside sialic acid (range, 3-37%).	N-Acetylneuraminic Acid	99-110	GRDX	Homo sapiens	57-60
1429695-9	1992	The dramatic GM3 increase and the decrease of NeuAc-nLc during monocytic differentiation are the consequences of the up-regulation of GM3 synthase and the down-regulation of Lc3Cer synthase, although the downstream enzymes are ready to catalyze their enzyme reactions.	N-Acetylneuraminic Acid	46-51	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	134-146
1482374-1	1992	Recombinant human tissue plasminogen activator expressed in murine epithelial cells carries, in part, sulfated N-glycans, which are characterized by the presence of a NeuAc alpha 3[SO4-6]Gal unit.	N-Acetylneuraminic Acid	167-172	chromosome 20 open reading frame 181	Homo sapiens	18-46
1337862-2	1992	Lactotransferrin isolated from a pool of mature bovine milk has been shown to contain N-glycosidically-linked glycans possessing N-acetylneuraminic acid, galactose, mannose, fucose, N-acetylglucosamine, and N-acetylgalactosamine.	N-Acetylneuraminic Acid	129-152	lactotransferrin	Bos taurus	0-16
1473746-5	1992	Ovine submaxillary mucin had a strong inhibitory activity toward the reaction between meconium extract and MA54 as well as MA61, suggesting that these moABs recognize NeuAc 2-6GalNAc epitope in meconium.	N-Acetylneuraminic Acid	167-172	LOC100508689	Homo sapiens	19-24
1471158-9	1992	WGA probably inhibits Ca2+ release produced by Cd2+ by binding to N-acetylneuraminic acid in the external domain of a plasma membrane receptor.	N-Acetylneuraminic Acid	66-89	CD2 molecule	Homo sapiens	47-50
1429695-9	1992	The dramatic GM3 increase and the decrease of NeuAc-nLc during monocytic differentiation are the consequences of the up-regulation of GM3 synthase and the down-regulation of Lc3Cer synthase, although the downstream enzymes are ready to catalyze their enzyme reactions.	N-Acetylneuraminic Acid	46-51	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	Homo sapiens	174-189
1429695-10	1992	The notable increase of NeuAc-nLc and the relative decrease of GM3 during granulocytic differentiation are the results of the unchanged level of GM3 synthase and the up-regulation of Lc3Cer synthase together with the activation of the downstream glycosyltransferases.	N-Acetylneuraminic Acid	24-29	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	Homo sapiens	183-198
1445223-1	1992	The low-molecular-mass human salivary mucin has at least two isoforms, MG2a and MG2b, that differ primarily in their sialic acid and fucose content.	N-Acetylneuraminic Acid	117-128	LOC100508689	Homo sapiens	38-43
1428227-4	1992	In cutaneous melanoma, GM3 ranged from 4.2% to 74.6% and GD3 from 22.1% to 91.8% of total lipid-bound sialic acid.	N-Acetylneuraminic Acid	102-113	GRDX	Homo sapiens	57-60
1358626-1	1992	Leukosialin (CD43) is a sialic acid-rich molecule with a relative molecular mass (M(r)) of 140,000 highly represented on polymorphonuclear neutrophils (PMN) and on most leukocytes.	N-Acetylneuraminic Acid	24-35	LOC105369247	Homo sapiens	0-11
1358626-1	1992	Leukosialin (CD43) is a sialic acid-rich molecule with a relative molecular mass (M(r)) of 140,000 highly represented on polymorphonuclear neutrophils (PMN) and on most leukocytes.	N-Acetylneuraminic Acid	24-35	sialophorin	Homo sapiens	13-17
1402019-3	1992	Degree of endogenous LOS sialylation and amount of sialic acid capsule were associated with each other and with susceptibility to killing by neutrophils for the non-2b:P1.2 strains.	N-Acetylneuraminic Acid	51-62	DNA polymerase epsilon 4, accessory subunit	Homo sapiens	168-172
1400416-2	1992	The Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase forms the NeuAc alpha 2,3Gal beta 1,3(4)GlcNAc sequences found in terminal carbohydrate groups of glycoproteins and glycolipids.	N-Acetylneuraminic Acid	64-69	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Rattus norvegicus	4-53
1429599-4	1992	Analysis on IEF was combined with a neuraminidase protection assay, in which sialic acid modification of the N-linked glycans present on Tfr and Class I molecules is used as a reporter group for cell surface expression.	N-Acetylneuraminic Acid	77-88	transferrin receptor	Homo sapiens	137-140
1357794-4	1992	We have prepared a CD45RB Mab termed "MT3" that binds to a sialic acid dependent epitope.	N-Acetylneuraminic Acid	59-70	protein tyrosine phosphatase receptor type C	Homo sapiens	19-23
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	N-Acetylneuraminic Acid	67-78	LOC100508689	Homo sapiens	97-102
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	N-Acetylneuraminic Acid	67-78	LOC100508689	Homo sapiens	146-151
1398908-5	1992	Sialic acids containing 2 mol or more of O-acetyl ester per mol of sialic acid were cleaved from mucin glycoproteins more slowly by sialidases of mucin oligosaccharide-degrading stains than were sialic acids containing 1 or 0 mol, and only N-acetyl- and mono-O-acetylated sialic acids were recovered from enzyme digests of a mucin containing di-O-acetylated sialic acids.	N-Acetylneuraminic Acid	67-78	LOC100508689	Homo sapiens	146-151
1357794-4	1992	We have prepared a CD45RB Mab termed "MT3" that binds to a sialic acid dependent epitope.	N-Acetylneuraminic Acid	59-70	metallothionein 3	Homo sapiens	38-41
1420106-1	1992	Recombinant glycosylated erythropoietin (EPO) was biotinylated with biotin-aminocaproyl hydrazide via periodate-treated sialic acid moieties and applied to sections of 64 tumors of the lower respiratory tract, comprising 19 primary adenocarcinomas, 19 epidermoid carcinomas, 13 large cell anaplastic carcinomas, 11 small cell lung carcinomas, 11 intrapulmonary metastases, 1 mesothelioma and 1 lymphocytic interstitial pneumonia.	N-Acetylneuraminic Acid	120-131	erythropoietin	Homo sapiens	25-39
1443568-2	1992	Derivatives of sialic acid-containing oligosaccharides were further desialylated with neuraminidase.	N-Acetylneuraminic Acid	15-26	neuraminidase 1	Homo sapiens	86-99
1530575-11	1992	N-Acetylneuraminic acid stimulated the activity of ACE.	N-Acetylneuraminic Acid	0-23	angiotensin-converting enzyme	Sus scrofa	51-54
1380096-5	1992	Infection of swine testicular cells with group C AmC-1 virus was also prevented by glycophorin A, fetuin, and neuraminidase treatment, suggesting that sialic acid constitutes an essential part of the cell receptor.	N-Acetylneuraminic Acid	151-162	glycophorin-A	Sus scrofa	83-96
1380096-5	1992	Infection of swine testicular cells with group C AmC-1 virus was also prevented by glycophorin A, fetuin, and neuraminidase treatment, suggesting that sialic acid constitutes an essential part of the cell receptor.	N-Acetylneuraminic Acid	151-162	alpha 2-HS glycoprotein	Sus scrofa	98-104
1380096-5	1992	Infection of swine testicular cells with group C AmC-1 virus was also prevented by glycophorin A, fetuin, and neuraminidase treatment, suggesting that sialic acid constitutes an essential part of the cell receptor.	N-Acetylneuraminic Acid	151-162	neuraminidase 1	Homo sapiens	110-123
1413991-3	1992	A significant increase in the percentage of sialic acid released was found when the O-acetyl group was cleaved by O-acetylesterase activity from certain substrates (bovine submandibular gland mucin, rat serum glycoproteins, human saliva glycoproteins, mouse erythrocyte stroma, chick embryonic brain gangliosides and bovine brain gangliosides).	N-Acetylneuraminic Acid	44-55	mucin 1, cell surface associated	Bos taurus	192-197
1420106-1	1992	Recombinant glycosylated erythropoietin (EPO) was biotinylated with biotin-aminocaproyl hydrazide via periodate-treated sialic acid moieties and applied to sections of 64 tumors of the lower respiratory tract, comprising 19 primary adenocarcinomas, 19 epidermoid carcinomas, 13 large cell anaplastic carcinomas, 11 small cell lung carcinomas, 11 intrapulmonary metastases, 1 mesothelioma and 1 lymphocytic interstitial pneumonia.	N-Acetylneuraminic Acid	120-131	erythropoietin	Homo sapiens	41-44
1322604-0	1992	Neuraminidase treatment of avian infectious bronchitis coronavirus reveals a hemagglutinating activity that is dependent on sialic acid-containing receptors on erythrocytes.	N-Acetylneuraminic Acid	124-135	neuraminidase 1	Homo sapiens	0-13
1497622-8	1992	IgG-1 derived from culture in serum-containing media had an intermediate sialic acid content and a lower incidence of outer-arm galactosylation than the other two preparations.	N-Acetylneuraminic Acid	73-84	LOC105243590	Mus musculus	0-5
1397383-13	1992	Sialic acid content in choriocarcinoma hCG was extremely lower compared to that in normal hCG.	N-Acetylneuraminic Acid	0-11	chorionic gonadotropin subunit beta 5	Homo sapiens	39-42
1476702-2	1992	The principal component of this variant transferrin containing one sialic acid residue per mole of protein was separated from other forms of transferrin by anion-exchange chromatography, followed by lectin affinity chromatography.	N-Acetylneuraminic Acid	67-78	transferrin	Rattus norvegicus	40-51
1601853-3	1992	One was previously shown to be NeuAc alpha 2-6Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc beta 1-1Cer.	N-Acetylneuraminic Acid	31-36	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	50-56
1377047-7	1992	Studies with leukocytes treated with proteases or neuraminidase have shown that the structures recognized by P-selectin are glycoproteins carrying sialic acid residues.	N-Acetylneuraminic Acid	147-158	neuraminidase 1	Homo sapiens	50-63
1377047-7	1992	Studies with leukocytes treated with proteases or neuraminidase have shown that the structures recognized by P-selectin are glycoproteins carrying sialic acid residues.	N-Acetylneuraminic Acid	147-158	selectin P	Homo sapiens	109-119
1499147-0	1992	The effect of ovine prolactin on the epididymal sialic acid concentration in male rats.	N-Acetylneuraminic Acid	48-59	prolactin	Rattus norvegicus	20-29
1499147-6	1992	When ovine prolactin was injected in orchidectomized rats, a dose-related increase in the level of sialic acid was observed in the epididymis.	N-Acetylneuraminic Acid	99-110	prolactin	Rattus norvegicus	11-20
1499147-10	1992	The physiological role(s) of epididymal sialic acid production in response to prolactin remain to be established.	N-Acetylneuraminic Acid	40-51	prolactin	Rattus norvegicus	78-87
1380634-2	1992	The reactivity of Nd2 was reduced by trypsin, but was not influenced by neuraminidase, so the epitope recognized by Nd2 may involve peptide but not sialic acid.	N-Acetylneuraminic Acid	148-159	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	116-119
1601853-3	1992	One was previously shown to be NeuAc alpha 2-6Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc beta 1-1Cer.	N-Acetylneuraminic Acid	31-36	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	65-71
1601853-3	1992	One was previously shown to be NeuAc alpha 2-6Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc beta 1-1Cer.	N-Acetylneuraminic Acid	31-36	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	65-71
1601853-3	1992	One was previously shown to be NeuAc alpha 2-6Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc beta 1-1Cer.	N-Acetylneuraminic Acid	31-36	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	65-71
1534115-2	1992	They bear on their plasma membrane a sialic acid-containing epitope (Ssp-3) defined by a series of monoclonal antibodies (mAbs).	N-Acetylneuraminic Acid	37-48	SUMO specific peptidase 3	Homo sapiens	69-74
1375936-15	1992	Although sialic acid and Le(x) are components of the P-selectin ligand and the E-selectin ligand, these results indicate that the ligands are related, having overlapping specificities, but are structurally distinct.	N-Acetylneuraminic Acid	9-20	selectin P ligand	Homo sapiens	53-70
1375936-15	1992	Although sialic acid and Le(x) are components of the P-selectin ligand and the E-selectin ligand, these results indicate that the ligands are related, having overlapping specificities, but are structurally distinct.	N-Acetylneuraminic Acid	9-20	selectin E	Homo sapiens	79-89
1398744-9	1992	Fluorometric determinations revealed that approximately the same percentage of sialic acid was released from sialidase-treated C4A3 and C4B1.	N-Acetylneuraminic Acid	79-90	complement C4B (Chido blood group)	Homo sapiens	136-140
1599413-7	1992	In this report we provide evidence that removal of terminal sialic acid from the Thr345-linked oligosaccharide chain of Pg2 is accompanied by the appearance of spontaneous amidolytic and fibrinolytic activity in the single-chain zymogen.	N-Acetylneuraminic Acid	60-71	delta like non-canonical Notch ligand 1	Homo sapiens	120-123
1512508-4	1992	Neuraminidase treatment of LDL from normal healthy donors produced sialic acid-depleted LDL (Ds-LDL) which was able to stimulate intracellular lipid accumulation.	N-Acetylneuraminic Acid	67-78	neuraminidase 1	Homo sapiens	0-13
1607947-11	1992	Neuraminidase digestion shifts the gp93 pattern to a more neutral pI but simplifies it only partially, indicating that variable sialic acid content explains the molecular diversity to some extent.	N-Acetylneuraminic Acid	128-139	neuraminidase 1	Homo sapiens	0-13
1573391-6	1992	Removal of sialic acid residues with neuraminidase lowers the apparent molecular mass of both glycoproteins by 5-6 kDa.	N-Acetylneuraminic Acid	11-22	neuraminidase 1	Homo sapiens	37-50
1616876-4	1992	In contrast, the carbohydrate composition of rat CBG indicated the presence of more than one sialic acid residue per antenna.	N-Acetylneuraminic Acid	93-104	serpin family A member 6	Rattus norvegicus	49-52
1616876-5	1992	It is not clear whether rat CBG contains a carbohydrate structure with sialic acids attached to both galactose and N-acetylglucosamine on the same antenna, or a terminal disialylated structure (sialic acid linked alpha 2-8 to sialic acid).	N-Acetylneuraminic Acid	71-82	serpin family A member 6	Rattus norvegicus	28-31
1381849-6	1992	HC II levels correlated significantly with AT III levels and with acute phase reactants including sialic acid, fibrinogen, and PAI-1.	N-Acetylneuraminic Acid	98-109	serpin family D member 1	Homo sapiens	0-5
1587278-2	1992	In this paper, we present the results of an investigation into the catalytic properties of CMP-Neu5Ac hydroxylase (Neu5Ac: N-acetylneuraminic acid) in high-speed supernatants of mouse liver.	N-Acetylneuraminic Acid	123-146	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Mus musculus	91-113
1533159-0	1992	Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional C1 complex.	N-Acetylneuraminic Acid	78-89	complement C1s	Homo sapiens	42-45
1533511-0	1992	Limited tryptic cleavage of complement factor H abrogates recognition of sialic acid-containing surfaces by the alternative pathway of complement.	N-Acetylneuraminic Acid	73-84	LOW QUALITY PROTEIN: complement factor H	Ovis aries	28-47
1577759-8	1992	The enzyme also converts N-glycolylneuraminic acid to its corresponding CMP-sialic acid (Km, 2.6 mM), whereas CMP-NeuAc, high CTP concentrations, and other nucleotides (CDP, CMP, ATP, UTP, GTP, and TTP) inhibited the enzyme to different extents.	N-Acetylneuraminic Acid	76-87	alpha tocopherol transfer protein	Rattus norvegicus	198-201
1577759-8	1992	The enzyme also converts N-glycolylneuraminic acid to its corresponding CMP-sialic acid (Km, 2.6 mM), whereas CMP-NeuAc, high CTP concentrations, and other nucleotides (CDP, CMP, ATP, UTP, GTP, and TTP) inhibited the enzyme to different extents.	N-Acetylneuraminic Acid	114-119	alpha tocopherol transfer protein	Rattus norvegicus	198-201
1590770-4	1992	Chemical analysis indicated that the putative palatal mucin was rich in sulphate, but poor in sialic acid.	N-Acetylneuraminic Acid	94-105	LOC100508689	Homo sapiens	54-59
1559234-6	1992	The effect of episialin overexpression on aggregation is probably not only due to the negative charge of its numerous sialic acid residues, since neuraminidase treatment only partially restored the aggregation capacity of the transfectants.	N-Acetylneuraminic Acid	118-129	mucin 1, cell surface associated	Homo sapiens	14-23
1586031-6	1992	In cattle with experimentally induced abscesses, serum alpha 1AG concentration increased for 7 to 10 days after F necrophorum inoculation, its change being parallel to that of sialic acid.	N-Acetylneuraminic Acid	176-187	alpha-1-acid glycoprotein	Bos taurus	55-64
1586031-7	1992	High concentration of alpha 1AG was found in naturally affected cattle and was highly correlated to sialic acid concentration.	N-Acetylneuraminic Acid	100-111	alpha-1-acid glycoprotein	Bos taurus	22-31
1606356-3	1992	Initial rates of sialic acid incorporation into the desialylated glycans of hCG alpha and hCG beta in the heterodimer were higher with the alpha-subunit.	N-Acetylneuraminic Acid	17-28	chorionic gonadotropin subunit beta 5	Homo sapiens	76-79
1555586-6	1992	The results demonstrate that human transferrin receptor from placenta predominantly carries diantennary and triantennary N-acetyllactosaminic glycans as well as hybrid-type species, the galactose residues of which being almost completely substituted with (alpha 2-3)-linked sialic acid residues.	N-Acetylneuraminic Acid	274-285	transferrin	Homo sapiens	35-46
1606356-8	1992	1H-NMR spectroscopy (400 MHz) of the glycan chains, alpha 6-sialylated in vitro, showed that the enzyme highly prefers the galactosyl residue at the Gal beta 1----4GlcNAc beta 1----2-Man alpha 1----3Man branch for attachment of the first mol of sialic acid into the diantennary glycans of desialylated hCG.	N-Acetylneuraminic Acid	245-256	chorionic gonadotropin subunit beta 5	Homo sapiens	302-305
1312106-4	1992	Terminal sialic acid residues were removed by neuraminidase treatment from the carbohydrate side chains of the heavily glycosylated gp120.	N-Acetylneuraminic Acid	9-20	neuraminidase 1	Homo sapiens	46-59
1312106-4	1992	Terminal sialic acid residues were removed by neuraminidase treatment from the carbohydrate side chains of the heavily glycosylated gp120.	N-Acetylneuraminic Acid	9-20	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	132-137
1312416-5	1992	Using g.c.-m.s., a decrease in sialic acid content has been observed in the major erythrocyte membrane glycoprotein, glycophorin A, obtained from nine diabetic patients compared with that from seven normal control subjects [median (range): 3.30 (0.01-11.90) versus 18.60 (3.20-32.60) micrograms/100 micrograms of protein, P less than 0.02].	N-Acetylneuraminic Acid	31-42	glycophorin A (MNS blood group)	Homo sapiens	117-130
1313570-2	1992	Lectin column chromatography reveals that 30% of IP3R in the thymus contains sialic acid, reflecting a plasma membrane association, in contrast to 5% of cerebellar IP3R.	N-Acetylneuraminic Acid	77-88	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	49-53
1518562-4	1992	Removal of sialic acid residues converted the multiple pl species to one form with a pl of 6.32 for NEP 2, and two forms with pls of 6.27 and 6.32 for NEP 1.	N-Acetylneuraminic Acid	11-22	membrane metallo-endopeptidase-like 1	Rattus norvegicus	100-105
1518562-4	1992	Removal of sialic acid residues converted the multiple pl species to one form with a pl of 6.32 for NEP 2, and two forms with pls of 6.27 and 6.32 for NEP 1.	N-Acetylneuraminic Acid	11-22	membrane metallo-endopeptidase	Rattus norvegicus	100-103
1518562-9	1992	These analyses demonstrate that rat kidney NEP exhibits sialic acid microheterogeneity resulting in two distinct change variants.	N-Acetylneuraminic Acid	56-67	membrane metallo-endopeptidase	Rattus norvegicus	43-46
1554367-8	1992	Neuraminidase treatment of alpha-L-fucosidase resulted in a decrease in the amount of the high-molecular-mass subunit and an increase in the amount of the low-molecular-mass subunit, suggesting that these subunits are related at least in part by sialic acid residues.	N-Acetylneuraminic Acid	246-257	neuraminidase 1	Homo sapiens	0-13
1371154-6	1992	Here we report that the carbohydrate analysis of L2/HNK-1-reactive P0 showed the presence of anionic structures containing sialic acid and sulphate in various combinations.	N-Acetylneuraminic Acid	123-134	beta-1,3-glucuronyltransferase 1	Homo sapiens	52-57
1735456-3	1992	Treated fibroblasts contained less ganglioside NeuAc alpha 2-3Gal beta 1-4GlcCer (GM3), presumably due to neuraminidase-catalyzed hydrolysis to lactosylceramide.	N-Acetylneuraminic Acid	47-52	neuraminidase 1	Homo sapiens	106-119
1377469-1	1992	The interferon antagonist sarcolectin, the protease inhibitor aprotinin and calcyclin whose expression is regulated by growth stimulation in quiescent fibroblasts display sialic acid-dependent binding to fetuin, visualized by solid-phase assays using biotinylated fetuin.	N-Acetylneuraminic Acid	171-182	keratin 7	Homo sapiens	26-37
1377469-1	1992	The interferon antagonist sarcolectin, the protease inhibitor aprotinin and calcyclin whose expression is regulated by growth stimulation in quiescent fibroblasts display sialic acid-dependent binding to fetuin, visualized by solid-phase assays using biotinylated fetuin.	N-Acetylneuraminic Acid	171-182	S100 calcium binding protein A6	Homo sapiens	76-85
1309720-6	1992	The specific biosynthetic defect in mutant strain COH1-11 was found to be in the activation of free sialic acid to CMP-sialic acid: CMP-sialic acid synthetase activity was present in the wild-type strain COH1 but was not detected in the asialo mutant strain COH1-11.	N-Acetylneuraminic Acid	100-111	vacuolar protein sorting 13 homolog B	Homo sapiens	50-57
1370931-5	1992	The 130-150-kD CD45 polypeptides carried extracellular CD45 epitopes, including the sialic acid-related UCHL1 epitope (CD45RO).	N-Acetylneuraminic Acid	84-95	protein tyrosine phosphatase receptor type C	Homo sapiens	15-19
1370931-5	1992	The 130-150-kD CD45 polypeptides carried extracellular CD45 epitopes, including the sialic acid-related UCHL1 epitope (CD45RO).	N-Acetylneuraminic Acid	84-95	ubiquitin C-terminal hydrolase L1	Homo sapiens	104-109
1370931-5	1992	The 130-150-kD CD45 polypeptides carried extracellular CD45 epitopes, including the sialic acid-related UCHL1 epitope (CD45RO).	N-Acetylneuraminic Acid	84-95	protein tyrosine phosphatase receptor type C	Homo sapiens	119-125
1309720-6	1992	The specific biosynthetic defect in mutant strain COH1-11 was found to be in the activation of free sialic acid to CMP-sialic acid: CMP-sialic acid synthetase activity was present in the wild-type strain COH1 but was not detected in the asialo mutant strain COH1-11.	N-Acetylneuraminic Acid	100-111	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	132-158
1309720-6	1992	The specific biosynthetic defect in mutant strain COH1-11 was found to be in the activation of free sialic acid to CMP-sialic acid: CMP-sialic acid synthetase activity was present in the wild-type strain COH1 but was not detected in the asialo mutant strain COH1-11.	N-Acetylneuraminic Acid	100-111	vacuolar protein sorting 13 homolog B	Homo sapiens	50-54
1309720-6	1992	The specific biosynthetic defect in mutant strain COH1-11 was found to be in the activation of free sialic acid to CMP-sialic acid: CMP-sialic acid synthetase activity was present in the wild-type strain COH1 but was not detected in the asialo mutant strain COH1-11.	N-Acetylneuraminic Acid	100-111	vacuolar protein sorting 13 homolog B	Homo sapiens	204-208
1309720-6	1992	The specific biosynthetic defect in mutant strain COH1-11 was found to be in the activation of free sialic acid to CMP-sialic acid: CMP-sialic acid synthetase activity was present in the wild-type strain COH1 but was not detected in the asialo mutant strain COH1-11.	N-Acetylneuraminic Acid	119-130	vacuolar protein sorting 13 homolog B	Homo sapiens	50-57
1309720-6	1992	The specific biosynthetic defect in mutant strain COH1-11 was found to be in the activation of free sialic acid to CMP-sialic acid: CMP-sialic acid synthetase activity was present in the wild-type strain COH1 but was not detected in the asialo mutant strain COH1-11.	N-Acetylneuraminic Acid	119-130	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	132-158
1309720-6	1992	The specific biosynthetic defect in mutant strain COH1-11 was found to be in the activation of free sialic acid to CMP-sialic acid: CMP-sialic acid synthetase activity was present in the wild-type strain COH1 but was not detected in the asialo mutant strain COH1-11.	N-Acetylneuraminic Acid	119-130	vacuolar protein sorting 13 homolog B	Homo sapiens	50-54
1310320-0	1992	A malaria invasion receptor, the 175-kilodalton erythrocyte binding antigen of Plasmodium falciparum recognizes the terminal Neu5Ac(alpha 2-3)Gal- sequences of glycophorin A.	N-Acetylneuraminic Acid	125-131	glycophorin A (MNS blood group)	Homo sapiens	160-173
1309720-6	1992	The specific biosynthetic defect in mutant strain COH1-11 was found to be in the activation of free sialic acid to CMP-sialic acid: CMP-sialic acid synthetase activity was present in the wild-type strain COH1 but was not detected in the asialo mutant strain COH1-11.	N-Acetylneuraminic Acid	119-130	vacuolar protein sorting 13 homolog B	Homo sapiens	204-208
1310320-5	1992	Most Neu5Ac on human erythrocytes is linked to galactose by alpha 2-3 and alpha 2-6 linkages on glycophorin A.	N-Acetylneuraminic Acid	5-11	immunoglobulin binding protein 1	Homo sapiens	74-83
1310320-5	1992	Most Neu5Ac on human erythrocytes is linked to galactose by alpha 2-3 and alpha 2-6 linkages on glycophorin A.	N-Acetylneuraminic Acid	5-11	glycophorin A (MNS blood group)	Homo sapiens	96-109
1310320-8	1992	Similar oligosaccharides containing Neu5Ac(alpha 2-6)Gal-linkages had only slight inhibitory effects.	N-Acetylneuraminic Acid	36-42	immunoglobulin binding protein 1	Homo sapiens	43-52
1310320-12	1992	We conclude that the Neu5Ac(a2,3)-Gal- determinant on O-linked tetrasaccharides of glycophorin A appear to be the preferential erythrocyte ligand for EBA-175.	N-Acetylneuraminic Acid	21-27	glycophorin A (MNS blood group)	Homo sapiens	83-96
12285731-3	1992	The measurement of sialyltransferase activity was based on the incorporation of radioactive sialic acid from CMP (14) C sialic acid) into asialofetuin.	N-Acetylneuraminic Acid	92-103	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	19-36
1310044-13	1992	13C NMR spectroscopic studies and carbohydrate analysis of the deglycosylation intermediates of the human mucin indicate that certain sialic acid containing and N-acetylglucosamine-containing oligosaccharides have elevated resistance to TFMSA treatment at 0 degrees C. By the use of neuraminidase, repeated mild TFMSA treatments, and multiple oxidations and beta-eliminations, the human mucin can be nearly completely deglycosylated.	N-Acetylneuraminic Acid	134-145	LOC100508689	Homo sapiens	106-111
1310044-13	1992	13C NMR spectroscopic studies and carbohydrate analysis of the deglycosylation intermediates of the human mucin indicate that certain sialic acid containing and N-acetylglucosamine-containing oligosaccharides have elevated resistance to TFMSA treatment at 0 degrees C. By the use of neuraminidase, repeated mild TFMSA treatments, and multiple oxidations and beta-eliminations, the human mucin can be nearly completely deglycosylated.	N-Acetylneuraminic Acid	134-145	neuraminidase 1	Homo sapiens	283-296
1310044-13	1992	13C NMR spectroscopic studies and carbohydrate analysis of the deglycosylation intermediates of the human mucin indicate that certain sialic acid containing and N-acetylglucosamine-containing oligosaccharides have elevated resistance to TFMSA treatment at 0 degrees C. By the use of neuraminidase, repeated mild TFMSA treatments, and multiple oxidations and beta-eliminations, the human mucin can be nearly completely deglycosylated.	N-Acetylneuraminic Acid	134-145	LOC100508689	Homo sapiens	387-392
12285731-3	1992	The measurement of sialyltransferase activity was based on the incorporation of radioactive sialic acid from CMP (14) C sialic acid) into asialofetuin.	N-Acetylneuraminic Acid	120-131	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	19-36
12285731-8	1992	Inhibition of sialyltransferase in human semen by the materials examined in this study can diminish the transfer of sialic acid, thus interfering with normal glycoprotein"s and glycolipid"s syntheses in semen and possibly also in other fluids and tissues.	N-Acetylneuraminic Acid	116-127	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	14-31
1333754-2	1992	The ability of gC of HSV type 1 (gC-1) to bind to the C3b fragment of C3 was found to be influenced by cell specific processing of gC-1 in a different manner, binding being remarkably enhanced in some cell lines following removal of sialic acid residues.	N-Acetylneuraminic Acid	233-244	solute carrier family 25 member 22	Homo sapiens	33-37
1443784-2	1992	The abnormal transferrin contains reduced amounts of carbohydrates, especially sialic acid, constituting its terminal trisaccharides biantennary chains.	N-Acetylneuraminic Acid	79-90	transferrin	Homo sapiens	13-24
1567173-7	1992	These data show that a) the diagnostic sensitivity of Sialic Acid (LSA/TSA) is more than 3 times higher than that of CEA and b) the response of Sialic Acid (LSA/TSA) to treatment is about 15% higher than that of CEA.	N-Acetylneuraminic Acid	144-155	CEA cell adhesion molecule 3	Homo sapiens	117-120
1567173-7	1992	These data show that a) the diagnostic sensitivity of Sialic Acid (LSA/TSA) is more than 3 times higher than that of CEA and b) the response of Sialic Acid (LSA/TSA) to treatment is about 15% higher than that of CEA.	N-Acetylneuraminic Acid	144-155	CEA cell adhesion molecule 3	Homo sapiens	212-215
1333754-2	1992	The ability of gC of HSV type 1 (gC-1) to bind to the C3b fragment of C3 was found to be influenced by cell specific processing of gC-1 in a different manner, binding being remarkably enhanced in some cell lines following removal of sialic acid residues.	N-Acetylneuraminic Acid	233-244	complement C3	Homo sapiens	54-57
1820026-1	1991	CMP-sialic acid:GM3 sialyltransferase (GD3 synthase; EC 2.4.99.8) was characterized in a membrane-enriched preparation (P2 pellet) from mouse embryos at embryonic day 12 (E-12).	N-Acetylneuraminic Acid	4-15	granulocyte macrophage antigen 3	Mus musculus	16-19
1590525-3	1992	Removal of sialic acid with neuraminidase revealed the same transferrin phenotypes as in their parents.	N-Acetylneuraminic Acid	11-22	neuraminidase 1	Homo sapiens	28-41
1590525-3	1992	Removal of sialic acid with neuraminidase revealed the same transferrin phenotypes as in their parents.	N-Acetylneuraminic Acid	11-22	transferrin	Homo sapiens	60-71
1576211-8	1992	Moreover, from 150 ps up to the end of the simulation, the value of the torsional angle omega of the NeuAc(alpha 2-6)Gal(beta 1-) linkage of the alpha-1,6-antenna continuously swung between 60 degrees and -60 degrees.	N-Acetylneuraminic Acid	101-106	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	121-127
1576211-9	1992	Finally, we observed that the values of the torsional angles of the three linkages: NeuAc(alpha 2-6)Gal(beta 1-), Gal(beta 1-4)GlcNAc(beta 1-) and GlcNAc(beta 1-2)Man(beta 1-) of each of the two antennae were different, demonstrating their asymmetric conformation.	N-Acetylneuraminic Acid	84-89	galanin and GMAP prepropeptide	Homo sapiens	90-140
1576211-9	1992	Finally, we observed that the values of the torsional angles of the three linkages: NeuAc(alpha 2-6)Gal(beta 1-), Gal(beta 1-4)GlcNAc(beta 1-) and GlcNAc(beta 1-2)Man(beta 1-) of each of the two antennae were different, demonstrating their asymmetric conformation.	N-Acetylneuraminic Acid	84-89	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	104-110
1740114-0	1992	The 2.2 A resolution crystal structure of influenza B neuraminidase and its complex with sialic acid.	N-Acetylneuraminic Acid	89-100	neuraminidase 1	Homo sapiens	54-67
1740114-1	1992	Influenza virus neuraminidase catalyses the cleavage of terminal sialic acid, the viral receptor, from carbohydrate chains on glycoproteins and glycolipids.	N-Acetylneuraminic Acid	65-76	neuraminidase 1	Homo sapiens	16-29
1820026-1	1991	CMP-sialic acid:GM3 sialyltransferase (GD3 synthase; EC 2.4.99.8) was characterized in a membrane-enriched preparation (P2 pellet) from mouse embryos at embryonic day 12 (E-12).	N-Acetylneuraminic Acid	4-15	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	39-51
1720810-5	1991	HECA-452 and ELAM-1 binding to lymphocytes or to isolated tonsillar HECA-452 antigen is abrogated by neuraminidase treatment implying a prominent role for sialic acid in CLA structure and function.	N-Acetylneuraminic Acid	155-166	hdc homolog, cell cycle regulator	Homo sapiens	0-4
1668531-3	1991	The results included observation of an increase in half-life of the N-acetylgalactosamine acetamido HN by more than an order of magnitude in GM2 compared to GA2, attributable to the presence of the additional N-acetylneuraminic acid residue.	N-Acetylneuraminic Acid	209-232	electron transfer flavoprotein subunit alpha	Homo sapiens	157-160
1720810-5	1991	HECA-452 and ELAM-1 binding to lymphocytes or to isolated tonsillar HECA-452 antigen is abrogated by neuraminidase treatment implying a prominent role for sialic acid in CLA structure and function.	N-Acetylneuraminic Acid	155-166	selectin E	Homo sapiens	13-19
1720810-5	1991	HECA-452 and ELAM-1 binding to lymphocytes or to isolated tonsillar HECA-452 antigen is abrogated by neuraminidase treatment implying a prominent role for sialic acid in CLA structure and function.	N-Acetylneuraminic Acid	155-166	neuraminidase 1	Homo sapiens	101-114
1940915-2	1991	We show here that GD3 is prevalent at all developmental periods of the rat retina from birth [50% of total gangliosidic N-acetylneuraminic acid (NeuNAc)] to adult (30% of total gangliosidic NeuNAc).	N-Acetylneuraminic Acid	120-143	GRDX	Homo sapiens	18-21
1720810-5	1991	HECA-452 and ELAM-1 binding to lymphocytes or to isolated tonsillar HECA-452 antigen is abrogated by neuraminidase treatment implying a prominent role for sialic acid in CLA structure and function.	N-Acetylneuraminic Acid	155-166	selectin P ligand	Homo sapiens	170-173
1940915-2	1991	We show here that GD3 is prevalent at all developmental periods of the rat retina from birth [50% of total gangliosidic N-acetylneuraminic acid (NeuNAc)] to adult (30% of total gangliosidic NeuNAc).	N-Acetylneuraminic Acid	145-151	GRDX	Homo sapiens	18-21
1720810-8	1991	In combination with the known requirement for terminal NeuAc alpha 2-3Gal and fucose residues attached to N-acetylglucosamine for ELAM-1 and HECA-452 binding, this finding suggests that CLA may comprise an additionally sialylated or otherwise modified form of sLex.	N-Acetylneuraminic Acid	55-60	selectin P ligand	Homo sapiens	186-189
1940915-2	1991	We show here that GD3 is prevalent at all developmental periods of the rat retina from birth [50% of total gangliosidic N-acetylneuraminic acid (NeuNAc)] to adult (30% of total gangliosidic NeuNAc).	N-Acetylneuraminic Acid	190-196	GRDX	Homo sapiens	18-21
1657976-9	1991	Analysis of the size of cell surface complex-type glycopeptides before and after digestion with neuraminidase and endo-beta-galactosidase suggested an increased sialic acid density, an increase in the number and/or length of polylactosaminoglycan chains, and an increased branching of the glycans upon N-ras induction.	N-Acetylneuraminic Acid	161-172	neuraminidase 1	Homo sapiens	96-109
1817798-5	1991	This M-protein may recognize carbohydrate epitope including sialic acid.	N-Acetylneuraminic Acid	60-71	myomesin 2	Homo sapiens	5-14
1657976-9	1991	Analysis of the size of cell surface complex-type glycopeptides before and after digestion with neuraminidase and endo-beta-galactosidase suggested an increased sialic acid density, an increase in the number and/or length of polylactosaminoglycan chains, and an increased branching of the glycans upon N-ras induction.	N-Acetylneuraminic Acid	161-172	galactosidase beta 1	Homo sapiens	119-137
1806553-5	1991	The separation of the pyridylamino oligosaccharides on the C18-silica column depended on the numbers and positions of sialic acid and N-acetylhexosamine residues; on the amide-silica column, the separation depended on the total number of sugar residues.	N-Acetylneuraminic Acid	118-129	Bardet-Biedl syndrome 9	Homo sapiens	59-62
1719556-3	1991	The ligand for one of these proteins, E-selectin (LECAM-2, ELAM-1) has been described by several groups to contain a polylactosamine structure bearing a terminal sialic acid residue and at least one fucose residue.	N-Acetylneuraminic Acid	162-173	selectin E	Homo sapiens	38-48
1719556-3	1991	The ligand for one of these proteins, E-selectin (LECAM-2, ELAM-1) has been described by several groups to contain a polylactosamine structure bearing a terminal sialic acid residue and at least one fucose residue.	N-Acetylneuraminic Acid	162-173	selectin E	Homo sapiens	50-57
1719556-3	1991	The ligand for one of these proteins, E-selectin (LECAM-2, ELAM-1) has been described by several groups to contain a polylactosamine structure bearing a terminal sialic acid residue and at least one fucose residue.	N-Acetylneuraminic Acid	162-173	selectin E	Homo sapiens	59-65
1719556-7	1991	We propose a structural model of functional groups necessary for recognition by E-selectin, based on these data and additional experiments on modifications of sialic acid and the reducing terminal saccharide.	N-Acetylneuraminic Acid	159-170	selectin E	Homo sapiens	80-90
1802382-1	1991	Neuraminidase substrates suitable for analysis of linkage specificity were enzymically synthesized in good yield by linking N-acetylneuraminic acid (Neup5Ac) to O-6 and O-3 of 4-nitrophenyl beta-D-galactopyranoside with beta-D-galactoside-alpha-(2----6)-sialyltransferase and beta-D-galactoside-alpha-(2----3)-sialyltransferase, respectively.	N-Acetylneuraminic Acid	124-147	neuraminidase 1	Homo sapiens	0-13
1938282-5	1991	Therefore, the neuraminidase of Acanthamoeba species could be relevant in the colonization and damage of the sialic acid-rich corneal epithelium and in the alterations of glycolipids associated with meningoencephalitis.	N-Acetylneuraminic Acid	109-120	neuraminidase 1	Homo sapiens	15-28
1777485-4	1991	Structural comparison between PSA and double-stranded DNA suggests that a sequence of eight sialic acid residues can mimic one large groove of the DNA.	N-Acetylneuraminic Acid	92-103	aminopeptidase puromycin sensitive	Homo sapiens	30-33
1682310-4	1991	This finding, as well as the ability of the solubilized receptor to interact with a Sambucus nigra L. lectin affinity column suggested that sialic acid residues are associated with SRIF receptors.	N-Acetylneuraminic Acid	140-151	somatostatin	Mus musculus	181-185
1682310-10	1991	These findings suggest that sialic acid residues in an alpha 2,6-configuration have a role in maintaining the SRIF receptor in a high affinity conformation for agonists.	N-Acetylneuraminic Acid	28-39	somatostatin	Mus musculus	110-114
1838790-8	1991	Phospholipase A and neuraminidase decreased the Ca2+ binding by 20-30%; this indicated that Ca2+ binding with the purified enzyme may be partly due to the phospholipids and sialic acid residues associated with the enzyme.	N-Acetylneuraminic Acid	173-184	phospholipase A and acyltransferase 1	Rattus norvegicus	0-15
1717159-2	1991	Data presented to date suggest that one ligand of CD62 includes CD15 (Lewis x determinant) and sialic acid.	N-Acetylneuraminic Acid	95-106	selectin P	Homo sapiens	50-54
1939090-13	1991	While these proteins contain sialic acid, binding assays and functional assays using neuraminidase-treated cells demonstrate that the functional interaction between C1q and the cell surface is not via sialic acid.	N-Acetylneuraminic Acid	29-40	complement C1q A chain	Homo sapiens	165-168
1721040-15	1991	Treatment of B-CLL cells and red cells with neuraminidase increased the binding of OKB4, suggesting that this epitope is masked by sialic acid.	N-Acetylneuraminic Acid	131-142	neuraminidase 1	Homo sapiens	44-57
1716283-3	1991	The increase in DAF by WGA was inhibited by N-acetyl glucosamine (10-50 mM) but by neither N-acetyl neuraminic acid nor removal of surface N-acetyl neuraminic acid with neuraminidase.	N-Acetylneuraminic Acid	139-163	CD55 molecule (Cromer blood group)	Homo sapiens	16-19
1654332-10	1991	Treatment of MPR-2A with endo-beta-galactosidase and/or neuraminidases followed by affinity chromatography revealed that polylactosamine and sialic acid residues impair the ability of MPR-2A to bind ligands.	N-Acetylneuraminic Acid	141-152	galactosidase beta 1	Bos taurus	30-48
1872812-5	1991	Highly purified exoglycosidases with well-defined specificities were used to prepare five derivatives of galactoglycoprotein in which sequential residues of N-acetylneuraminic acid, galactose, N-acetylglucosamine, a second galactose and N-acetylgalactosamine were removed with 83% of the total carbohydrate cleaved.	N-Acetylneuraminic Acid	157-180	sialophorin	Homo sapiens	105-124
1716543-0	1991	Monoclonal antibodies VIB-E3, IB5 and HB9 to the leucocyte/epithelial antigen CD24 resemble BA-1 in recognizing sialic acid-dependent epitope(s).	N-Acetylneuraminic Acid	112-123	motor neuron and pancreas homeobox 1	Homo sapiens	38-41
1716543-0	1991	Monoclonal antibodies VIB-E3, IB5 and HB9 to the leucocyte/epithelial antigen CD24 resemble BA-1 in recognizing sialic acid-dependent epitope(s).	N-Acetylneuraminic Acid	112-123	CD24 molecule	Homo sapiens	78-82
1860865-0	1991	Purification, characterization, and studies on biosynthesis of a 59-kDa bone sialic acid-containing protein (BSP) from rat mandible using a monoclonal antibody.	N-Acetylneuraminic Acid	77-88	integrin-binding sialoprotein	Rattus norvegicus	109-112
1860865-4	1991	The sialoprotein (59-kDa bone sialoprotein (BSP)) with a molecular weight of 59,000 contained 1.4% sialic acid but no detectable phosphorus.	N-Acetylneuraminic Acid	99-110	cysteine-rich secretory protein 3	Rattus norvegicus	4-16
1860865-4	1991	The sialoprotein (59-kDa bone sialoprotein (BSP)) with a molecular weight of 59,000 contained 1.4% sialic acid but no detectable phosphorus.	N-Acetylneuraminic Acid	99-110	cysteine-rich secretory protein 3	Rattus norvegicus	30-42
1860865-4	1991	The sialoprotein (59-kDa bone sialoprotein (BSP)) with a molecular weight of 59,000 contained 1.4% sialic acid but no detectable phosphorus.	N-Acetylneuraminic Acid	99-110	integrin-binding sialoprotein	Rattus norvegicus	44-47
1714447-2	1991	ELAM-1 cDNA transfectants were found to bind Sialyl Lea (sialylated lacto-N-fucopentaose II) or sialylated Lewis a antigen (NeuAc alpha 2-3Gal beta 1-3(Fuc alpha 1-4)GlcNAc), as well as or slightly better than Sialyl Lex (sialylated lacto-N-fucopentaose III) or sialylated Lewis X antigen (NeuAc alpha 2-3 Gal beta 1-4(Fuc alpha 1-3)GlcNAc).	N-Acetylneuraminic Acid	124-129	selectin E	Homo sapiens	0-6
2050106-3	1991	Purified sialoadhesin, a glycoprotein of 185 kd apparent Mr, agglutinated sheep or human erythrocytes at nanomolar concentrations in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	135-146	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	9-21
1855482-7	1991	Sulfate-containing peaks were monitored by radioactivity, and sialic acid-containing ones were identified by their reduced charge after neuraminidase or acid treatment.	N-Acetylneuraminic Acid	62-73	neuraminidase 1	Homo sapiens	136-149
1829631-8	1991	In addition, the patients" fibrinogen showed normal polymerization of preformed fibrin monomers, normal sialic acid content, and normal binding to ADP or epinephrine-stimulated platelets.	N-Acetylneuraminic Acid	104-115	fibrinogen beta chain	Homo sapiens	27-37
1799374-3	1991	Titration data established that the inhibitory activity of mucin was associated with its acidic component as the fraction enriched in sialic acid and sulfate showed 16-fold higher inhibitory titer than that of the intact mucin.	N-Acetylneuraminic Acid	134-145	LOC100508689	Homo sapiens	59-64
2050106-5	1991	To investigate the specificity for sialic acid, we studied the interaction of sialoadhesin with derivatized human erythrocytes, glycoproteins, and glycolipids.	N-Acetylneuraminic Acid	35-46	sialic acid binding Ig like lectin 1	Homo sapiens	78-90
2050106-6	1991	In conclusion, sialoadhesin specifically recognizes the oligosaccharide sequence Neu5Ac alpha 2----3Gal beta 1----3GalNAc in either sialoglycoproteins or gangliosides.	N-Acetylneuraminic Acid	81-87	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	15-27
1712251-3	1991	This enzyme specifically transfers alpha (2-3)-linked sialic acid from extrinsic host-derived macromolecules to parasite surface molecules, leading to the assembly of Ssp-3, a trypomastigote-specific epitope.	N-Acetylneuraminic Acid	54-65	SUMO specific peptidase 3	Homo sapiens	167-172
1711075-0	1991	Antibody MT3 is reactive with a novel exon B-associated 190-kDa sialic acid-dependent epitope of the leukocyte common antigen complex.	N-Acetylneuraminic Acid	64-75	metallothionein 3	Homo sapiens	9-12
1711075-9	1991	It can be concluded that MT3 recognizes additional heterogeneity in the leukocyte common Ag complex, that is based on the differential expression of sialic acid-dependent determinants associated with exon B-encoded sequences.	N-Acetylneuraminic Acid	149-160	metallothionein 3	Homo sapiens	25-28
1726506-9	1991	The removal of the negative charge at cell surface, especially due to sialic acid, allows more anti-CEA antibodies to react.	N-Acetylneuraminic Acid	70-81	CEA cell adhesion molecule 3	Homo sapiens	100-103
2062831-1	1991	The neural cell adhesion molecule, N-CAM, changes at the cell surface during development, from a highly sialylated form [polysialic acid (PSA)-linked N-CAM, PSA-N-CAM] to several isoforms containing less sialic acid.	N-Acetylneuraminic Acid	125-136	neural cell adhesion molecule 1	Rattus norvegicus	35-40
2062831-1	1991	The neural cell adhesion molecule, N-CAM, changes at the cell surface during development, from a highly sialylated form [polysialic acid (PSA)-linked N-CAM, PSA-N-CAM] to several isoforms containing less sialic acid.	N-Acetylneuraminic Acid	125-136	neural cell adhesion molecule 1	Rattus norvegicus	150-155
2062831-1	1991	The neural cell adhesion molecule, N-CAM, changes at the cell surface during development, from a highly sialylated form [polysialic acid (PSA)-linked N-CAM, PSA-N-CAM] to several isoforms containing less sialic acid.	N-Acetylneuraminic Acid	125-136	neural cell adhesion molecule 1	Rattus norvegicus	150-155
1712251-5	1991	Monoclonal antibodies that recognize sialic acid residues of Ssp-3 inhibit attachment of trypomastigotes to host cells, suggesting that the unusual trans-sialidase provides Ssp-3 with structural features required for target cell recognition.	N-Acetylneuraminic Acid	37-48	SUMO specific peptidase 3	Homo sapiens	61-66
1712251-5	1991	Monoclonal antibodies that recognize sialic acid residues of Ssp-3 inhibit attachment of trypomastigotes to host cells, suggesting that the unusual trans-sialidase provides Ssp-3 with structural features required for target cell recognition.	N-Acetylneuraminic Acid	37-48	SUMO specific peptidase 3	Homo sapiens	173-178
1828514-4	1991	We found that variations in terminal sialic acid or O-linked sugar moieties were associated with drastic differences in reactivity with some of the CD45R antibodies.	N-Acetylneuraminic Acid	37-48	protein tyrosine phosphatase receptor type C	Homo sapiens	148-153
2052617-11	1991	These results indicate that the net negative charge of podocalyxin is most likely derived from sulfate as well as from sialic acid residues.	N-Acetylneuraminic Acid	119-130	podocalyxin-like	Rattus norvegicus	55-66
2033257-5	1991	Blockage of cathepsin B activity with leupeptin restored the 2D(nonequilibrium pH gradient gel electrophoresis/SDS) PAGE patterns of Ii and sialic acid-derivatized forms of Ii seen without the protease.	N-Acetylneuraminic Acid	140-151	cathepsin B	Homo sapiens	12-23
1891065-5	1991	Here, we report the identification of another NCAM isoform of 95 kDa that is apparent on tissues following either N-glycanase or neuraminidase treatment to remove carbohydrate and sialic acid residues from the molecule respectively.	N-Acetylneuraminic Acid	180-191	neural cell adhesion molecule 1	Homo sapiens	46-50
1891065-5	1991	Here, we report the identification of another NCAM isoform of 95 kDa that is apparent on tissues following either N-glycanase or neuraminidase treatment to remove carbohydrate and sialic acid residues from the molecule respectively.	N-Acetylneuraminic Acid	180-191	neuraminidase 1	Homo sapiens	129-142
1713644-7	1991	Selective enzymatic removal of sialic acid showed that +A.FN had both sialic acids in an alpha 2----3 linkage, whereas -A.FN apparently had one alpha 2----3 and one alpha 2----6-linked sialic acid.	N-Acetylneuraminic Acid	31-42	fibronectin 1	Rattus norvegicus	58-60
1946584-0	1991	Alcohol intoxication and sialic acid in erythrocyte membrane and in serum transferrin.	N-Acetylneuraminic Acid	25-36	transferrin	Homo sapiens	74-85
1867379-4	1991	Using mild oxidation conditions for antibody derivatization, sialic acid residues were identified as attachment sites for the cross-linker molecules, since after desialylation of antibody 16-88 by neuraminidase virtually no cross-linker molecules could be incorporated.	N-Acetylneuraminic Acid	61-72	neuraminidase 1	Homo sapiens	197-210
2005884-6	1991	FGF-5 is secreted from transfected 3T3 cells and from human tumor cells as glycoproteins containing heterogeneous amounts of sialic acid.	N-Acetylneuraminic Acid	125-136	fibroblast growth factor 5	Mus musculus	0-5
1709165-8	1991	Sialic acid was therefore utilized as a candidate receptor to analyze potential interaction schemes with HA3/87.92.6.	N-Acetylneuraminic Acid	0-11	A-kinase anchoring protein 13	Homo sapiens	105-108
2045131-8	1991	Desialylation of C1-INH significantly reduced its binding affinity for neutrophils, indicating that the membrane receptor sites on neutrophils could be specific for the binding of sialic acid residues on C1-INH.	N-Acetylneuraminic Acid	180-191	serpin family G member 1	Homo sapiens	17-23
2045131-8	1991	Desialylation of C1-INH significantly reduced its binding affinity for neutrophils, indicating that the membrane receptor sites on neutrophils could be specific for the binding of sialic acid residues on C1-INH.	N-Acetylneuraminic Acid	180-191	serpin family G member 1	Homo sapiens	204-210
2045131-9	1991	Overall, our studies indicate that neutrophils or other leucocytes possess specific surface binding sites for the sialic acid-containing portion of C1-INH.	N-Acetylneuraminic Acid	114-125	serpin family G member 1	Homo sapiens	148-154
2024473-6	1991	Wheat germ agglutinin, a lectin which blocks binding to sialic acid and N-acetylglucosamine residues, substantially reduced binding of radiolabeled GDVII and BeAn viruses.	N-Acetylneuraminic Acid	56-67	brain expressed, associated with Nedd4, 1	Mus musculus	158-162
1999428-0	1991	Purification to apparent homogeneity by immunoaffinity chromatography and partial characterization of the GM3 ganglioside-forming enzyme, CMP-sialic acid:lactosylceramide alpha 2,3-sialyltransferase (SAT-1), from rat liver Golgi.	N-Acetylneuraminic Acid	142-153	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Rattus norvegicus	154-198
1999428-0	1991	Purification to apparent homogeneity by immunoaffinity chromatography and partial characterization of the GM3 ganglioside-forming enzyme, CMP-sialic acid:lactosylceramide alpha 2,3-sialyltransferase (SAT-1), from rat liver Golgi.	N-Acetylneuraminic Acid	142-153	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	200-205
1713644-7	1991	Selective enzymatic removal of sialic acid showed that +A.FN had both sialic acids in an alpha 2----3 linkage, whereas -A.FN apparently had one alpha 2----3 and one alpha 2----6-linked sialic acid.	N-Acetylneuraminic Acid	70-81	fibronectin 1	Rattus norvegicus	58-60
1999428-1	1991	CMP-sialic acid:lactosylceramide alpha 2,3-sialyltransferase (SAT-1) has been purified approximately 40,000-fold to apparent homogeneity from rat liver Golgi.	N-Acetylneuraminic Acid	4-15	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Rattus norvegicus	16-60
1999428-1	1991	CMP-sialic acid:lactosylceramide alpha 2,3-sialyltransferase (SAT-1) has been purified approximately 40,000-fold to apparent homogeneity from rat liver Golgi.	N-Acetylneuraminic Acid	4-15	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	62-67
1999428-6	1991	SAT-1 specifically catalyzes the transfer of N-acetylneuraminic acid (NeuAc, sialic acid) to lactosylceramide (Gal beta 1-4Glc beta 1-O-ceramide), forming GM3 ganglioside.	N-Acetylneuraminic Acid	45-68	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	0-5
1998515-0	1991	Special considerations in the purification of the GM3 ganglioside-forming enzyme, CMP-sialic acid:lactosylceramide alpha 2-3 sialyltransferase (SAT-1): effects of protease inhibitors on rat hepatic SAT-1 activity.	N-Acetylneuraminic Acid	86-97	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	144-149
1999428-6	1991	SAT-1 specifically catalyzes the transfer of N-acetylneuraminic acid (NeuAc, sialic acid) to lactosylceramide (Gal beta 1-4Glc beta 1-O-ceramide), forming GM3 ganglioside.	N-Acetylneuraminic Acid	70-75	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	0-5
1999428-6	1991	SAT-1 specifically catalyzes the transfer of N-acetylneuraminic acid (NeuAc, sialic acid) to lactosylceramide (Gal beta 1-4Glc beta 1-O-ceramide), forming GM3 ganglioside.	N-Acetylneuraminic Acid	77-88	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	0-5
2004022-2	1991	The ITP patients" platelet counts ranged from 15 to 80 X 10(9)/l and they had much higher mean volumes and significantly higher (two-fold) total cell and neuraminidase-labile surface sialic acid contents expressed per unit cell than normal.	N-Acetylneuraminic Acid	183-194	neuraminidase 1	Homo sapiens	154-167
1990974-5	1991	Treatment of intact cells with neuraminidase also resulted in increased membrane-bound Hb, which correlated with the amount of sialic acid released.	N-Acetylneuraminic Acid	127-138	neuraminidase 1	Homo sapiens	31-44
1877990-0	1991	Charge forms of serum and whey transferrin in rat differ in the sialic acid content of their glycan chains: immunological implications.	N-Acetylneuraminic Acid	64-75	transferrin	Rattus norvegicus	31-42
2067026-3	1991	The physiological role of this sugar is not clear, but neuraminidase, which specifically hydrolyzes sialic acid from the sarcolemma, has been found to increase calcium exchange, cause electrophysiological abnormalities, and enhance the transient (T) calcium current in cardiac myocytes.	N-Acetylneuraminic Acid	100-111	neuraminidase 1	Homo sapiens	55-68
1704009-10	1991	We conclude that neutrophils constitutively express a glycoprotein receptor for GMP-140, which contains sialic acid residues that are essential for function.	N-Acetylneuraminic Acid	104-115	selectin P	Homo sapiens	80-87
1846577-3	1991	The removal of sialic acid from either one or both subunits sharply increased the [125I]bovine TSH binding-inhibiting activity of hCG in the receptor assay.	N-Acetylneuraminic Acid	15-26	chorionic gonadotropin subunit beta 5	Homo sapiens	130-133
2055602-0	1991	Antigenic studies on an enzymatically sialylated carbohydrate: NeuAc(alpha 2-3)Gal(beta 1-3)[GlcNAc(beta 1-6)]GalNAc.	N-Acetylneuraminic Acid	63-68	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	83-91
2055602-0	1991	Antigenic studies on an enzymatically sialylated carbohydrate: NeuAc(alpha 2-3)Gal(beta 1-3)[GlcNAc(beta 1-6)]GalNAc.	N-Acetylneuraminic Acid	63-68	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	100-108
2055602-8	1991	As the immune response matured (greater than 40 days), there was an increase in the proportion of the antibodies that were directed to the NeuAc(alpha 2-3)Gal(beta 1-3)GalNAc residue compared to the nonsialylated form.	N-Acetylneuraminic Acid	139-144	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	159-167
2067026-5	1991	Neuraminidase removed up to 57% of total sialic acid from the cells.	N-Acetylneuraminic Acid	41-52	neuraminidase 1	Homo sapiens	0-13
2067026-6	1991	45Ca exchange was measured and neuraminidase was found to increase cell calcium proportional to the amount of sialic acid removed (18.6 +/- 0.8 mmol/kg dry w, maximally).	N-Acetylneuraminic Acid	110-121	neuraminidase 1	Homo sapiens	31-44
2067026-9	1991	These results indicate that neuraminidase, probably by removing sarcolemmal sialic acid residues, greatly augments cellular calcium in cultured cardiac myocytes.	N-Acetylneuraminic Acid	76-87	neuraminidase 1	Homo sapiens	28-41
1899391-7	1991	Using ricin-resistant MDCK cells the role of the terminal galactose and sialic acid residues in the sorting of the gp 80 complex was analysed.	N-Acetylneuraminic Acid	72-83	clusterin	Canis lupus familiaris	115-120
2035854-10	1991	Since these malformations were similar to those we have previously reported when we treated similarly staged chick embryos with WGA, there is a possibility that the sialic acid residues recognized and bound by the lectin are those associated with the N-CAM molecule.	N-Acetylneuraminic Acid	165-176	neural cell adhesion molecule 1	Gallus gallus	251-256
1825020-14	1991	Supplementation of neuraminidase-treated Lp(a) with N-acetylneuraminic acid (NANA) at concentrations comparable to the naturally occurring amounts of NANA in the Lp(a) protein moiety led to an increase of the lag-phase yielding values which were comparable to those observed with native Lp(a).	N-Acetylneuraminic Acid	52-75	neuraminidase 1	Homo sapiens	19-32
1825020-14	1991	Supplementation of neuraminidase-treated Lp(a) with N-acetylneuraminic acid (NANA) at concentrations comparable to the naturally occurring amounts of NANA in the Lp(a) protein moiety led to an increase of the lag-phase yielding values which were comparable to those observed with native Lp(a).	N-Acetylneuraminic Acid	52-75	lipoprotein(a)	Homo sapiens	41-46
1825020-14	1991	Supplementation of neuraminidase-treated Lp(a) with N-acetylneuraminic acid (NANA) at concentrations comparable to the naturally occurring amounts of NANA in the Lp(a) protein moiety led to an increase of the lag-phase yielding values which were comparable to those observed with native Lp(a).	N-Acetylneuraminic Acid	52-75	lipoprotein(a)	Homo sapiens	162-167
1825020-14	1991	Supplementation of neuraminidase-treated Lp(a) with N-acetylneuraminic acid (NANA) at concentrations comparable to the naturally occurring amounts of NANA in the Lp(a) protein moiety led to an increase of the lag-phase yielding values which were comparable to those observed with native Lp(a).	N-Acetylneuraminic Acid	52-75	lipoprotein(a)	Homo sapiens	162-167
1997323-12	1991	However, the alpha-1,3-Man-linked antenna in rTf-1 as well as rTf-2 had the sequence: Neu5Ac(alpha 2-3)Gal(beta 1-3)[Neu5Ac(alpha 2-6)]GlcNAc(beta 1-2)Man.	N-Acetylneuraminic Acid	86-92	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	Rattus norvegicus	45-50
1997323-12	1991	However, the alpha-1,3-Man-linked antenna in rTf-1 as well as rTf-2 had the sequence: Neu5Ac(alpha 2-3)Gal(beta 1-3)[Neu5Ac(alpha 2-6)]GlcNAc(beta 1-2)Man.	N-Acetylneuraminic Acid	86-92	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	107-113
1997323-12	1991	However, the alpha-1,3-Man-linked antenna in rTf-1 as well as rTf-2 had the sequence: Neu5Ac(alpha 2-3)Gal(beta 1-3)[Neu5Ac(alpha 2-6)]GlcNAc(beta 1-2)Man.	N-Acetylneuraminic Acid	86-92	immunoglobulin binding protein 1	Homo sapiens	124-133
1997323-12	1991	However, the alpha-1,3-Man-linked antenna in rTf-1 as well as rTf-2 had the sequence: Neu5Ac(alpha 2-3)Gal(beta 1-3)[Neu5Ac(alpha 2-6)]GlcNAc(beta 1-2)Man.	N-Acetylneuraminic Acid	86-92	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	142-150
1997323-12	1991	However, the alpha-1,3-Man-linked antenna in rTf-1 as well as rTf-2 had the sequence: Neu5Ac(alpha 2-3)Gal(beta 1-3)[Neu5Ac(alpha 2-6)]GlcNAc(beta 1-2)Man.	N-Acetylneuraminic Acid	117-123	Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	Rattus norvegicus	45-50
1997323-12	1991	However, the alpha-1,3-Man-linked antenna in rTf-1 as well as rTf-2 had the sequence: Neu5Ac(alpha 2-3)Gal(beta 1-3)[Neu5Ac(alpha 2-6)]GlcNAc(beta 1-2)Man.	N-Acetylneuraminic Acid	117-123	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	107-113
1997323-12	1991	However, the alpha-1,3-Man-linked antenna in rTf-1 as well as rTf-2 had the sequence: Neu5Ac(alpha 2-3)Gal(beta 1-3)[Neu5Ac(alpha 2-6)]GlcNAc(beta 1-2)Man.	N-Acetylneuraminic Acid	117-123	immunoglobulin binding protein 1	Homo sapiens	124-133
1997323-13	1991	In addition, the alpha-1,6-Man-linked antenna deviated in rTf-2 from the standard structure by having the sequence: Neu5Ac(alpha 2-3)Gal(beta 1-3)GlcNAc(beta 1-2)Man.	N-Acetylneuraminic Acid	116-122	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	137-143
1997323-13	1991	In addition, the alpha-1,6-Man-linked antenna deviated in rTf-2 from the standard structure by having the sequence: Neu5Ac(alpha 2-3)Gal(beta 1-3)GlcNAc(beta 1-2)Man.	N-Acetylneuraminic Acid	116-122	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	153-161
1868686-11	1991	The polymorphism of the horse alpha 1 B-glycoproteins may be due in part to differing numbers of terminal sialic acid residues and the higher electrophoretic mobility of the donkey alpha 1 B-glycoprotein may be due in part to increased sialylation.	N-Acetylneuraminic Acid	106-117	alpha-1B-glycoprotein	Equus asinus	30-52
15374461-0	1991	Age dependency of the sialic acid content of fibrinogen.	N-Acetylneuraminic Acid	22-33	fibrinogen beta chain	Homo sapiens	45-55
15374461-4	1991	The higher plasma SA is caused by increasing concentrations of glycoproteins like fibrinogen, but also by a higher content of SA/mg protein, as has been shown for fibrinogen.	N-Acetylneuraminic Acid	18-20	fibrinogen beta chain	Homo sapiens	82-92
15374461-4	1991	The higher plasma SA is caused by increasing concentrations of glycoproteins like fibrinogen, but also by a higher content of SA/mg protein, as has been shown for fibrinogen.	N-Acetylneuraminic Acid	18-20	fibrinogen beta chain	Homo sapiens	163-173
15374461-7	1991	An increased red cell aggregation with fibrinogen of healthy elderly correlated with its SA content, but SA is most probably only indicating an altered protein heterogeneity in the aged and not a causative factor that influences erythrocyte aggregation.	N-Acetylneuraminic Acid	89-91	fibrinogen beta chain	Homo sapiens	39-49
1793377-7	1991	Lectin binding by tumorous cells containing mucus was enhanced after the elimination of sialic acid as a result of the incubation with neuraminidase.	N-Acetylneuraminic Acid	88-99	neuraminidase 1	Homo sapiens	135-148
1984792-3	1991	Treatment of Pltgp40 with neuraminidase resulted in a 5,000-dalton reduction in its Mr and a 1.5 Unit alkaline shift in the isoelectric point, indicating the presence of a large number of sialic acid residues.	N-Acetylneuraminic Acid	188-199	neuraminidase 1	Homo sapiens	26-39
21043955-2	1991	A large proportion of the platelet sialic acid is neuraminidase-labile.	N-Acetylneuraminic Acid	35-46	neuraminidase 1	Homo sapiens	50-63
1702821-6	1991	These results indicated that the content of sialic acid of DAF in the epidermis was different from that of buffy coat cells.	N-Acetylneuraminic Acid	44-55	CD55 molecule (Cromer blood group)	Homo sapiens	59-62
1806363-1	1991	An activator protein that stimulates the enzymic hydrolysis of sialic acid from gangliosides by ganglioside sialidase was fractionated from human liver.	N-Acetylneuraminic Acid	63-74	neuraminidase 3	Homo sapiens	96-117
1991473-8	1991	The oligosaccharides at Asn78 (hLH alpha) are sialylated rather than sulphated and contain the unique sequence NeuAc alpha 2-6 GalNAc beta 1-4GlcNAc beta 1-2 Man alpha 1-3 as part of the majority of mono- and disialylated compounds.	N-Acetylneuraminic Acid	111-116	glycoprotein hormones, alpha polypeptide	Homo sapiens	31-40
21043955-5	1991	Platelet subpopulations have been isolated with differing amounts of sialic acid and cleavage of platelet sialic acid by neuraminidase is associated with loss of platelets from the circulation.	N-Acetylneuraminic Acid	106-117	neuraminidase 1	Homo sapiens	121-134
1701214-11	1990	The data support the proposal that bradykinin and analogues act like mastoparan, substance P, and compound 48/80, interacting first with sialic acid residues of the cell surface and then with Gi-like proteins, inducing phospholipase C activation and intracellular calcium mobilization.	N-Acetylneuraminic Acid	137-148	kininogen 1	Bos taurus	35-45
2268312-8	1990	Digestion of purified isoforms with a battery of glycosidic enzymes indicate that secreted forms of murine TNF contain both sialic acid and asparagine(N)-linked chains.	N-Acetylneuraminic Acid	124-135	tumor necrosis factor	Mus musculus	107-110
2125279-1	1990	ASA-NeuAc2en, a photoreactive arylazide derivative of sialic acid, is shown to be a powerful competitive inhibitor of lysosomal neuraminidase from bovine testis (Ki approximately 21 microM).	N-Acetylneuraminic Acid	54-65	neuraminidase 1	Bos taurus	128-141
1701352-5	1990	CMP-NeuAc:GM3 sialyltransferase, the enzyme that synthesizes GD3 by transfer of sialic acid to GM3, also had tumor-associated elevation during the course of diethylnitrosamine-induction of rat hepatomas.	N-Acetylneuraminic Acid	80-91	GRDX	Homo sapiens	61-64
2269277-1	1990	Suppressive effects of sialic acid in the expression of biological activity of human erythropoietin in vitro.	N-Acetylneuraminic Acid	23-34	erythropoietin	Homo sapiens	85-99
1701214-11	1990	The data support the proposal that bradykinin and analogues act like mastoparan, substance P, and compound 48/80, interacting first with sialic acid residues of the cell surface and then with Gi-like proteins, inducing phospholipase C activation and intracellular calcium mobilization.	N-Acetylneuraminic Acid	137-148	tachykinin precursor 1	Bos taurus	81-92
2287131-0	1990	Correlation between haptoglobin and sialic acid or mucoprotein in diseased bovine serum.	N-Acetylneuraminic Acid	36-47	haptoglobin	Bos taurus	20-31
2242561-2	1990	In this new method, 10 microL of serum or plasma is pretreated with neuraminidase (EC 3.2.1.18), which removes the sialic acid residues from apo E and eliminates additional bands, thereby ensuring correct phenotype assignment.	N-Acetylneuraminic Acid	115-126	neuraminidase 1	Homo sapiens	68-81
2262006-0	1990	Purification and characterization of CMP-NeuAc:GM1 (Gal beta 1-4GalNAc) alpha 2-3 sialyltransferase from rat brain.	N-Acetylneuraminic Acid	41-46	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Rattus norvegicus	52-99
1700907-0	1990	Requirement for sialic acid on neutrophils in a GMP-140 (PADGEM) mediated adhesive interaction with activated platelets.	N-Acetylneuraminic Acid	16-27	selectin P	Homo sapiens	48-55
1700907-0	1990	Requirement for sialic acid on neutrophils in a GMP-140 (PADGEM) mediated adhesive interaction with activated platelets.	N-Acetylneuraminic Acid	16-27	selectin P	Homo sapiens	57-63
1700907-7	1990	These results indicate that the ligand for GMP-140 requires sialic acid and suggest that an alpha 2,6 linkage may be critical.	N-Acetylneuraminic Acid	60-71	selectin P	Homo sapiens	43-50
2082812-6	1990	For a human salivary mucin (MG-2) it has been described that sialic acid in the sequence NeuAc (alpha 2,3)Gal(beta 1,3)GalNac- was specifically involved in the interaction with S. sanguis strains, in contrast to S. rattus BHT.	N-Acetylneuraminic Acid	61-72	LOC100508689	Homo sapiens	21-26
2082812-6	1990	For a human salivary mucin (MG-2) it has been described that sialic acid in the sequence NeuAc (alpha 2,3)Gal(beta 1,3)GalNac- was specifically involved in the interaction with S. sanguis strains, in contrast to S. rattus BHT.	N-Acetylneuraminic Acid	61-72	mucin 7, secreted	Homo sapiens	28-32
2082812-6	1990	For a human salivary mucin (MG-2) it has been described that sialic acid in the sequence NeuAc (alpha 2,3)Gal(beta 1,3)GalNac- was specifically involved in the interaction with S. sanguis strains, in contrast to S. rattus BHT.	N-Acetylneuraminic Acid	89-94	LOC100508689	Homo sapiens	21-26
2082812-6	1990	For a human salivary mucin (MG-2) it has been described that sialic acid in the sequence NeuAc (alpha 2,3)Gal(beta 1,3)GalNac- was specifically involved in the interaction with S. sanguis strains, in contrast to S. rattus BHT.	N-Acetylneuraminic Acid	89-94	mucin 7, secreted	Homo sapiens	28-32
2242561-2	1990	In this new method, 10 microL of serum or plasma is pretreated with neuraminidase (EC 3.2.1.18), which removes the sialic acid residues from apo E and eliminates additional bands, thereby ensuring correct phenotype assignment.	N-Acetylneuraminic Acid	115-126	apolipoprotein E	Homo sapiens	141-146
1697799-0	1990	Monoclonal antibody BA-1 to the human B lymphocyte marker CD24 recognizes a sialic acid (N-acetylneuraminic acid) dependent epitope in multi-valent display on peptide.	N-Acetylneuraminic Acid	76-87	CD24 molecule	Homo sapiens	58-62
2249733-8	1990	We conclude that significant quantities of sialic acid are present in the normal human trabecular meshwork as neuraminidase-sensitive alpha-ketosidically linked terminal residues of the polypeptides.	N-Acetylneuraminic Acid	43-54	neuraminidase 1	Homo sapiens	110-123
1964451-0	1990	Participation of cytochrome b5 in CMP-N-acetylneuraminic acid hydroxylation in mouse liver cytosol.	N-Acetylneuraminic Acid	38-61	cytochrome b5 type A (microsomal)	Mus musculus	17-30
1964451-1	1990	The activity of CMP-N-acetylneuraminic acid hydroxylase, that converts CMP-N-acetylneuraminic acid (CMP-NeuAc) to CPM-N-glycolylneuraminic acid (CMP-NeuGc), in mouse liver was determined by a newly developed HPLC method using non-radioactive CMP-NeuAc as a substrate.	N-Acetylneuraminic Acid	104-109	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Mus musculus	16-55
2171591-2	1990	In the present studies, purified electroplax sodium channels were treated with neuraminidase to remove sialic acid residues and then examined for functional changes in planar lipid bilayers.	N-Acetylneuraminic Acid	103-114	neuraminidase 1	Homo sapiens	79-92
1709806-5	1990	Treatment of the cells with neuraminidase to remove sialic acid residues increased the proportion of patients showing increased p-glycoprotein to 52%.	N-Acetylneuraminic Acid	52-63	neuraminidase 1	Homo sapiens	28-41
1709806-5	1990	Treatment of the cells with neuraminidase to remove sialic acid residues increased the proportion of patients showing increased p-glycoprotein to 52%.	N-Acetylneuraminic Acid	52-63	ATP binding cassette subfamily B member 1	Homo sapiens	128-142
1976735-5	1990	However, the determinant(s) recognized by the anti-CD43 autoantibodies was present on a large proportion of circulating T lymphocytes, but masked from antibody recognition by sialic acid residues.	N-Acetylneuraminic Acid	175-186	sialophorin	Homo sapiens	51-55
2226299-6	1990	Sulfate-containing peaks were monitored by radioactivity, and sialic acid-containing peaks were identified by their shift to lower charge after treatment with neuraminidase.	N-Acetylneuraminic Acid	62-73	neuraminidase 1	Homo sapiens	159-172
2222467-0	1990	Special considerations in the purification of the GM3 ganglioside forming enzyme, CMP-sialic acid:lactosylceramide alpha 2-3 sialyltransferase (SAT-1): solubilization of SAT-1 with lauryldimethylamine oxide.	N-Acetylneuraminic Acid	86-97	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	144-149
2222467-0	1990	Special considerations in the purification of the GM3 ganglioside forming enzyme, CMP-sialic acid:lactosylceramide alpha 2-3 sialyltransferase (SAT-1): solubilization of SAT-1 with lauryldimethylamine oxide.	N-Acetylneuraminic Acid	86-97	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	170-175
2087937-4	1990	In severely overweight non-insulin-dependent diabetics the decrease of total sialic acid was less pronounced compared to that found in healthy subjects.	N-Acetylneuraminic Acid	77-88	insulin	Homo sapiens	27-34
2167157-4	1990	Beside gangliosides, both antibodies recognized the carbohydrate determinant carried by glycophorin A on very rare Cad-positive human RBC; the structure of which is GalNAc beta 1----4(NeuAc alpha 2----3)Gal beta 1----3(NeuAc alpha 2---- 6)GalNAc alpha 1----Ser/Thr.	N-Acetylneuraminic Acid	184-189	glycophorin A (MNS blood group)	Homo sapiens	88-101
1697799-0	1990	Monoclonal antibody BA-1 to the human B lymphocyte marker CD24 recognizes a sialic acid (N-acetylneuraminic acid) dependent epitope in multi-valent display on peptide.	N-Acetylneuraminic Acid	89-112	CD24 molecule	Homo sapiens	58-62
1697799-1	1990	Evidence is presented that monoclonal antibody BA-1, directed against a marker (CD24) of human lymphocytes of B cell lineage, recognizes a sialic acid-dependent epitope.	N-Acetylneuraminic Acid	139-150	CD24 molecule	Homo sapiens	80-84
1697799-3	1990	Expression of the epitope was enhanced following alkaline saponification of bovine submaxillary mucin, which converts O-acetylated neuraminic acid residues to N-acetylneuraminic acid.	N-Acetylneuraminic Acid	159-182	mucin 1, cell surface associated	Bos taurus	96-101
2379952-8	1990	Chemical deglycosylation of the purified mucin preparation with trifluoromethane sulfonic acid was carried out at 20 degrees C for 3 1/2 h. Sialic acid, fucose, galactose, and N-acetylglucosamine were completely removed, whereas traces of N-acetylgalactosamine were still detected.	N-Acetylneuraminic Acid	140-151	LOC100508689	Homo sapiens	41-46
2198284-1	1990	We and others previously described the melanoma-associated oncofetal glycosphingolipid antigen 9-O-acetyl-GD3, a disialoganglioside O-acetylated at the 9-position of the outer sialic acid residue.	N-Acetylneuraminic Acid	176-187	GRDX	Homo sapiens	106-109
2378933-8	1990	Treatment of rABP forms with exoglycosidases confirmed the presence of externally disposed fucose, sialic acid, mannose, and galactose residues.	N-Acetylneuraminic Acid	99-110	sex hormone binding globulin	Rattus norvegicus	13-17
2152185-5	1990	Recombinant D-factor is heavily glycosylated with 30% by weight neutral sugar and 12% sialic acid.	N-Acetylneuraminic Acid	86-97	LIF interleukin 6 family cytokine	Homo sapiens	12-20
2198284-13	1990	Selective periodate oxidation showed that both the inner and outer sialic acid residues of GD3 incorporated 3H-label in the in vitro reaction, and showed similar turnover of N-acetylation in the pulse-chase study.	N-Acetylneuraminic Acid	67-78	GRDX	Homo sapiens	91-94
2289463-4	1990	Neuraminidase from different sources and peptide-N-glycosidase F were applied to investigate the presence of sialic acid and/or carbohydrate chains in human catalase.	N-Acetylneuraminic Acid	109-120	neuraminidase 1	Homo sapiens	0-13
2289463-4	1990	Neuraminidase from different sources and peptide-N-glycosidase F were applied to investigate the presence of sialic acid and/or carbohydrate chains in human catalase.	N-Acetylneuraminic Acid	109-120	catalase	Homo sapiens	157-165
2141816-2	1990	Here, we determined the in vitro and in vivo bioactivity of recombinant FSH produced by CHO mutant cells deficient in the glycosylation enzyme N-acetylglucosamine transferase-I (NAGT-), resulting in glycoproteins with asparagine-linked (GlcNAc)2(Mannose)5 oligosaccharides, or mutant cells defective in sialic acid transport into the Golgi (ST-).	N-Acetylneuraminic Acid	303-314	solute carrier family 5 member 1	Homo sapiens	178-182
1695648-10	1990	These results clearly show the glycoprotein nature of CD38 molecule, which includes 2 to 4 N-linked oligosaccharide chains containing sialic acid residues.	N-Acetylneuraminic Acid	134-145	CD38 molecule	Homo sapiens	54-58
2381164-2	1990	A sensitive assay for sialic acid, based upon the specific degradation of free sialic acid by N-acetylneuraminic acid aldolase, was developed to measure small amounts of sialic acid in human plasma.	N-Acetylneuraminic Acid	22-33	N-acetylneuraminate pyruvate lyase	Homo sapiens	94-126
2381164-2	1990	A sensitive assay for sialic acid, based upon the specific degradation of free sialic acid by N-acetylneuraminic acid aldolase, was developed to measure small amounts of sialic acid in human plasma.	N-Acetylneuraminic Acid	79-90	N-acetylneuraminate pyruvate lyase	Homo sapiens	94-126
2381164-2	1990	A sensitive assay for sialic acid, based upon the specific degradation of free sialic acid by N-acetylneuraminic acid aldolase, was developed to measure small amounts of sialic acid in human plasma.	N-Acetylneuraminic Acid	79-90	N-acetylneuraminate pyruvate lyase	Homo sapiens	94-126
2385230-6	1990	The labeled A2AR demonstrates a sensitivity to neuraminidase, as evidenced by an increased mobility on gel electrophoresis, suggesting the receptors contain a glycan component containing terminal sialic acid.	N-Acetylneuraminic Acid	196-207	adenosine A2a receptor	Homo sapiens	12-16
2385230-6	1990	The labeled A2AR demonstrates a sensitivity to neuraminidase, as evidenced by an increased mobility on gel electrophoresis, suggesting the receptors contain a glycan component containing terminal sialic acid.	N-Acetylneuraminic Acid	196-207	neuraminidase 1	Homo sapiens	47-60
2229016-5	1990	In this paper, we report a modification of this HPLC/FAB/MS method, which was used for the separation and characterization of neutral glycosphingolipids (GlcCer, LacCer, Gb3Cer, Gb4Cer, and IV3 alpha GalNAc-Gb4Cer) and monosialogangliosides [GM3(NeuAc or NeuGc), GM2 (NeuAc or NeuGc), and GM1 (NeuAc or NeuGc)].	N-Acetylneuraminic Acid	246-251	FA complementation group B	Homo sapiens	53-56
2229016-5	1990	In this paper, we report a modification of this HPLC/FAB/MS method, which was used for the separation and characterization of neutral glycosphingolipids (GlcCer, LacCer, Gb3Cer, Gb4Cer, and IV3 alpha GalNAc-Gb4Cer) and monosialogangliosides [GM3(NeuAc or NeuGc), GM2 (NeuAc or NeuGc), and GM1 (NeuAc or NeuGc)].	N-Acetylneuraminic Acid	268-273	FA complementation group B	Homo sapiens	53-56
2229016-5	1990	In this paper, we report a modification of this HPLC/FAB/MS method, which was used for the separation and characterization of neutral glycosphingolipids (GlcCer, LacCer, Gb3Cer, Gb4Cer, and IV3 alpha GalNAc-Gb4Cer) and monosialogangliosides [GM3(NeuAc or NeuGc), GM2 (NeuAc or NeuGc), and GM1 (NeuAc or NeuGc)].	N-Acetylneuraminic Acid	268-273	FA complementation group B	Homo sapiens	53-56
1718060-1	1990	Goblet cells in normal colon mucosa from 100 individuals histochemically showed two major "mucin types" in sialic acid composition.	N-Acetylneuraminic Acid	107-118	LOC100508689	Homo sapiens	91-96
2142734-3	1990	The cells were washed and treated with clostridial neuraminidase to release accessible sialic acid; this was quantitated using a fluorometric assay.	N-Acetylneuraminic Acid	87-98	neuraminidase 1	Homo sapiens	51-64
2114451-4	1990	Electrophoretic analysis of tyrosinases in the soluble fractions of these melanoma cells demonstrates that the alteration of soluble tyrosinase isozymes by all the processing inhibitors is associated with a dose-dependent loss of sialic acid-rich T1 tyrosinase and the concomitant appearance or increase of sialic acid-poor tyrosinases.	N-Acetylneuraminic Acid	230-241	tyrosinase	Mus musculus	133-143
2114451-4	1990	Electrophoretic analysis of tyrosinases in the soluble fractions of these melanoma cells demonstrates that the alteration of soluble tyrosinase isozymes by all the processing inhibitors is associated with a dose-dependent loss of sialic acid-rich T1 tyrosinase and the concomitant appearance or increase of sialic acid-poor tyrosinases.	N-Acetylneuraminic Acid	307-318	tyrosinase	Mus musculus	133-143
2247885-7	1990	Treatment of a number of WM-66-negative B-cell lines with neuraminidase resulted in WM-66 binding, indicating that the antigen exists in a covert form masked by sialic acid residues on a wider spectrum of cell types than was initially apparent.	N-Acetylneuraminic Acid	161-172	neuraminidase 1	Homo sapiens	58-71
2340365-3	1990	Data obtained for lactones of GD3 (NeuAc alpha 2----8NeuAc alpha 2----3Gal beta 1----4Glc beta 1----1Cer) using negative ion FAB mass spectrometry of underivatized materials, negative ion FAB mass spectrometry following ammonolysis, and positive ion FAB mass spectrometry following ammonolysis and permethylation are presented and discussed.	N-Acetylneuraminic Acid	35-40	GRDX	Homo sapiens	30-33
2167230-7	1990	These results suggest that parainfluenza virus decreases the affinity of agonists for some of the muscarinic receptors in the lung, and for all of the muscarinic receptors in the heart due to its neuraminidase activity, which results in removal of sialic acid.	N-Acetylneuraminic Acid	248-259	neuraminidase 1	Homo sapiens	196-209
2330584-7	1990	This finding was confirmed by observations of qualitative modifications in the fibrinogen caused by CCl4 inhalation, such as an increase in sialic acid content, which has been previously described.	N-Acetylneuraminic Acid	140-151	C-C motif chemokine ligand 4	Rattus norvegicus	100-104
1692629-0	1990	Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor H.	N-Acetylneuraminic Acid	111-122	complement factor H	Homo sapiens	149-157
1692629-8	1990	The binding site for sialic acid appears to reside on factor H, since factor H bound to heparin-agarose and to sialic acid-bearing fetuinagarose, whereas C3b bound to neither under the same conditions.	N-Acetylneuraminic Acid	21-32	complement factor H	Homo sapiens	54-62
1692629-8	1990	The binding site for sialic acid appears to reside on factor H, since factor H bound to heparin-agarose and to sialic acid-bearing fetuinagarose, whereas C3b bound to neither under the same conditions.	N-Acetylneuraminic Acid	21-32	complement factor H	Homo sapiens	70-78
1692629-8	1990	The binding site for sialic acid appears to reside on factor H, since factor H bound to heparin-agarose and to sialic acid-bearing fetuinagarose, whereas C3b bound to neither under the same conditions.	N-Acetylneuraminic Acid	21-32	endogenous retrovirus group K member 3	Homo sapiens	154-157
1692629-8	1990	The binding site for sialic acid appears to reside on factor H, since factor H bound to heparin-agarose and to sialic acid-bearing fetuinagarose, whereas C3b bound to neither under the same conditions.	N-Acetylneuraminic Acid	111-122	complement factor H	Homo sapiens	54-62
1692629-8	1990	The binding site for sialic acid appears to reside on factor H, since factor H bound to heparin-agarose and to sialic acid-bearing fetuinagarose, whereas C3b bound to neither under the same conditions.	N-Acetylneuraminic Acid	111-122	complement factor H	Homo sapiens	70-78
1694466-3	1990	Two of the Mabs (No 11 and 21) lost their immunoreactivities towards rat kidney GGT in the presence of N-acetyl-neuraminic acid, while immunoreactivities of the other Mabs were unchanged.	N-Acetylneuraminic Acid	103-127	gamma-glutamyltransferase 1	Rattus norvegicus	80-83
2161375-7	1990	The treatment with periodic acid, neraminidase, trypsin and pronase revealed that antigenic epitopes of Pak-1 and Pak-2 may be composed of complex polysaccharide structure rather than terminal sialic acid residues.	N-Acetylneuraminic Acid	193-204	p21 (RAC1) activated kinase 1	Homo sapiens	104-109
2161375-7	1990	The treatment with periodic acid, neraminidase, trypsin and pronase revealed that antigenic epitopes of Pak-1 and Pak-2 may be composed of complex polysaccharide structure rather than terminal sialic acid residues.	N-Acetylneuraminic Acid	193-204	p21 (RAC1) activated kinase 2	Homo sapiens	114-119
2318210-12	1990	The constituent monosaccharides of the carbohydrate structures of rCD4 were found to be fucose, mannose, galactose, N-acetylglucosamine and N-acetylneuraminic acid.	N-Acetylneuraminic Acid	140-163	Cd4 molecule	Rattus norvegicus	66-70
2156701-3	1990	Here we have demonstrated the presence of O-linked sugar (0.85 mol/mol erythropoietin) composed of sialic acid and Gal beta(1-3)GalNAc.	N-Acetylneuraminic Acid	99-110	erythropoietin	Homo sapiens	71-85
2340811-7	1990	The lectin WGA binds to the sialic acid residues of glycoconjugates and to N-acetylglucosamine.	N-Acetylneuraminic Acid	28-39	galectin 3	Gallus gallus	4-10
1691720-5	1990	The mature alpha- and beta-subunits, secreted by BeWo cells as well as subunits of urinary hCG which are usually used as a standard hCG secreted by normal placental cells, were sensitive to neuraminidase treatment indicating that these subunits have terminal sialic acid(s).	N-Acetylneuraminic Acid	259-270	chorionic gonadotropin subunit beta 5	Homo sapiens	91-94
2302705-5	1990	Natural (melanoma- or buttermilk-derived) 9-O-acetyl-GD3 was O-acetylated solely on the sialic acid moiety.	N-Acetylneuraminic Acid	88-99	GRDX	Homo sapiens	53-56
2340811-8	1990	Treatment of embryos with Limulus polyphemus lectin (LPL), which also binds to sialic acid, produced results similar to those of WGA.	N-Acetylneuraminic Acid	79-90	galectin 3	Gallus gallus	45-51
2153431-2	1990	Human primary germ cell tumors were analyzed for the presence of the ganglioside GM2 using three specific monoclonal antibodies which can distinguish the molecular species of the sialic acid moiety: the antibody MK1-16 is specific for N-acetyl GM2, MK2-34 is specific for N-glycolyl GM2, and MK1-17 detects both N-acetyl and N-glycolyl GM2.	N-Acetylneuraminic Acid	179-190	epithelial cell adhesion molecule	Homo sapiens	212-218
2341370-3	1990	The microheterogeneous nature of both factors, observed on isoelectric focusing, is derived from the difference of the number of terminal sialic acid residues bound to the carbohydrate chains of the EPO molecule.	N-Acetylneuraminic Acid	138-149	erythropoietin	Homo sapiens	199-202
2153450-4	1990	Long polysialic acid units composed of alpha-(2,8)-linked N-acetylneuraminic acid units, which in mammals are found exclusively on NCAM, were present on SC-1 antigens in SCLC.	N-Acetylneuraminic Acid	58-81	neural cell adhesion molecule 1	Homo sapiens	131-135
2183047-3	1990	The enhanced infection is prevented by Vibrio cholerae neuraminidase, an enzyme whose activity is not inhibited by HDL, suggesting that sialic acid is involved in T. cruzi-host interaction.	N-Acetylneuraminic Acid	136-147	neuraminidase 1	Homo sapiens	55-68
2212700-1	1990	Immunoisoelectrofocusing (IIEF) reveals a microheterogeneity of human serum IgA controlled by an autosomal polymorphic gene, termed S. The microheterogeneity disappears when sialic acid is removed from serum glycoproteins by neuraminidase treatment.	N-Acetylneuraminic Acid	174-185	CD79a molecule	Homo sapiens	76-79
2212700-1	1990	Immunoisoelectrofocusing (IIEF) reveals a microheterogeneity of human serum IgA controlled by an autosomal polymorphic gene, termed S. The microheterogeneity disappears when sialic acid is removed from serum glycoproteins by neuraminidase treatment.	N-Acetylneuraminic Acid	174-185	neuraminidase 1	Homo sapiens	225-238
2212700-2	1990	It can be postulated, therefore, that S encodes a sialyltransferase which attaches sialic acid at the outer prosthetic chains of IgA.	N-Acetylneuraminic Acid	83-94	CD79a molecule	Homo sapiens	129-132
2302211-1	1990	A CMP-sialic acid: GM3 sialyltransferase (GD3 synthase) and a CMP-sialic acid: LacCer sialyltransferase (GM3 synthase) have been purified 10,000- and 3,000-fold, respectively, from the Triton X-100 extract of rat brain.	N-Acetylneuraminic Acid	6-17	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	42-54
2302211-1	1990	A CMP-sialic acid: GM3 sialyltransferase (GD3 synthase) and a CMP-sialic acid: LacCer sialyltransferase (GM3 synthase) have been purified 10,000- and 3,000-fold, respectively, from the Triton X-100 extract of rat brain.	N-Acetylneuraminic Acid	66-77	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Rattus norvegicus	105-117
2295623-4	1990	The sialic acid moieties on the Asn-linked oligosaccharides of both endogenous glycoproteins and recombinant bLH(CHO) are exclusively alpha 2,3-linked, suggesting that the alpha 2,6-sialyl-transferase is not active in CHO cells.	N-Acetylneuraminic Acid	4-15	beta-galactoside alpha-2,6-sialyltransferase 1	Cricetulus griseus	172-200
2404574-3	1990	Pulse labeling, chemical deglycosylation, and 125I-wheat germ lectin blotting suggested that the ciprofibrate-induced isoform of CE 9 differed in the posttranslational modification of its oligosaccharides and contained more sialic acid.	N-Acetylneuraminic Acid	224-235	basigin (Ok blood group)	Rattus norvegicus	129-133
2104915-6	1990	The protein contains carbohydrate groups that play an important role in the function of the protein, as indicated by the fact that inhibition of glycosylation by tunicamycin and cleavage of sialic acid from the protein with neuraminidase result in a significant increase of perforin binding to CTL.	N-Acetylneuraminic Acid	190-201	neuraminidase 1	Homo sapiens	224-237
2108716-8	1990	The combined data are consistent with the following intra- and/or extracellular modifications of apoAII: (a) modification of the apoAII which results in the net loss of two positive charges; (b) glycosylation of the modified proapoAII with carbohydrate chains containing sialic acid; (c) proteolytic removal of the prosegment and cyclization of the N-terminal glutamine.	N-Acetylneuraminic Acid	271-282	apolipoprotein A2	Homo sapiens	97-103
2106194-2	1990	Markedly decreased level of platelet membrane glycoprotein GPIIb was observed in the patient"s platelets by terminal sialic acid labelling method, whereas no significant changes in the levels of glycoproteins including GPIIb could be detected either by penultimate galactose labelling or by tyrosine/histidine labelling.	N-Acetylneuraminic Acid	117-128	integrin subunit alpha 2b	Homo sapiens	59-64
2108716-8	1990	The combined data are consistent with the following intra- and/or extracellular modifications of apoAII: (a) modification of the apoAII which results in the net loss of two positive charges; (b) glycosylation of the modified proapoAII with carbohydrate chains containing sialic acid; (c) proteolytic removal of the prosegment and cyclization of the N-terminal glutamine.	N-Acetylneuraminic Acid	271-282	apolipoprotein A2	Homo sapiens	129-135
2121293-0	1990	Leu-enkephalin induced alteration of enzymes and sialic acid levels in vivo.	N-Acetylneuraminic Acid	49-60	prodynorphin	Mus musculus	0-14
2121293-1	1990	The influence in mice of 10 mg/kg Leu-enkephalin (LENK) on the activity of hepatic enzymes in serum and liver and sialic acid concentration in serum and spleen is described.	N-Acetylneuraminic Acid	114-125	prodynorphin	Mus musculus	34-48
2121293-1	1990	The influence in mice of 10 mg/kg Leu-enkephalin (LENK) on the activity of hepatic enzymes in serum and liver and sialic acid concentration in serum and spleen is described.	N-Acetylneuraminic Acid	114-125	prodynorphin	Mus musculus	50-54
2121293-5	1990	While the level of serum sialic acid remained unchanged, it decreased in the spleen 6 h after a single LENK injection.	N-Acetylneuraminic Acid	25-36	prodynorphin	Mus musculus	103-107
2121293-9	1990	These data may be relevant for use of LENK in combined chemo-immunotherapy, since liver enzyme changes may alter drug metabolism, and since sialic acid plays a regulatory role in immune processes.	N-Acetylneuraminic Acid	140-151	prodynorphin	Mus musculus	38-42
1690645-2	1990	By lectin affinity immunoelectrophoresis, PAPP-A contained sialic acid, glucose/mannose and N-acetyl-alpha-D-galactosamine.	N-Acetylneuraminic Acid	59-70	pappalysin 1	Homo sapiens	42-48
2110861-4	1990	Following RA treatment, cell-surface sialic acid residues on gp160 were also more intensely labeled by NaIO4 oxidation and subsequent NaB[3H]4 reduction than were those on gp160 of untreated cells.	N-Acetylneuraminic Acid	37-48	leucyl/cystinyl aminopeptidase	Mus musculus	61-66
2328944-1	1990	A simple and rapid procedure using anion exchange chromatography was established for determinations of the activity of ganglioside GD3 synthase (CMP-NeuAc: GM3, alpha 2----8 sialyltransferase) which catalyzes the conversion of ganglioside GM3 to GD3.	N-Acetylneuraminic Acid	149-154	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	131-143
2307194-2	1990	Sialic acid, terminally bound on carbohydrate side-chains of glycoproteins, was released after treatment with neuraminidase and measured by an enzymatic colorimetric test.	N-Acetylneuraminic Acid	0-11	neuraminidase 1	Homo sapiens	110-123
1688937-5	1990	Deglycosylation of LAMP indicates that it contains N-linked high mannose or hybrid sugars and a minor amount of sialic acid.	N-Acetylneuraminic Acid	112-123	limbic system associated membrane protein	Homo sapiens	19-23
2324552-2	1990	Using Meg-CSF-enriched fractions, we established that the moiety has the following characteristics: 1) portions of the molecules having Meg-CSF activity have sialic acid, probably with a biantennary structure, and beta-galactose residues as the terminal and penultimate sugars; 2) disulfide residues are an essential chemical group of the molecule and are located on its surface; and 3) Meg-CSF activity is stable in n-propanol, but not in acetonitrile with trifluoroacetic acid.	N-Acetylneuraminic Acid	158-169	thrombopoietin	Homo sapiens	136-143
2153181-3	1990	The data suggest that SA11 rotavirus binds to a specific sialic acid structure on BSM different from the sialic acids recognized by other viruses.	N-Acetylneuraminic Acid	57-68	mucin-19	Bos taurus	82-85
33816461-9	2021	These cells exhibit pathologically relevant mutations of GNE (UDP N-acetylneuraminic 2-epimerase/N-acetylmannosamine kinase), a key sialic acid biosynthetic enzyme.	N-Acetylneuraminic Acid	132-143	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	57-60
1967152-8	1990	These results indicate that the transformational changes of pancreatic cancer gamma-GTP are mainly induced in the sugar chains of the enzyme molecule, resulting in lower content of sialic acid and higher content of fucose and bisecting GlcNAc residue (the beta-N-acetylglucosamine residue linked at the C-4 of the beta-mannosyl residue of the trimannosyl core of the asparagine-linked sugar chain) as compared with the normal pancreatic enzyme.	N-Acetylneuraminic Acid	181-192	inactive glutathione hydrolase 2	Homo sapiens	78-87
33823179-6	2021	The spike and ACE2 proteins are highly glycosylated with sialic acid modifications that direct viral-host interactions and infection.	N-Acetylneuraminic Acid	57-68	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	4-9
33823179-6	2021	The spike and ACE2 proteins are highly glycosylated with sialic acid modifications that direct viral-host interactions and infection.	N-Acetylneuraminic Acid	57-68	angiotensin converting enzyme 2	Homo sapiens	14-18
33769035-5	2021	Sialoglycan microarray studies showed that esterase-inactivated porcine torovirus hemagglutinin-esterase bound strongly to sialoglycans containing a more stable 9-N-acetylated sialic acid analog, but these compounds were less resistant to periodate oxidation treatment compared to their 9-O-acetyl counterparts.	N-Acetylneuraminic Acid	176-187	hemagglutinin esterase	Porcine torovirus	82-104
33806943-8	2021	Neu5Ac, as well as GlcNAc sugars, showed a similar interaction trend with wheat germ agglutinin (WGA) lectin.	N-Acetylneuraminic Acid	0-6	C-type lectin BfL-2	Crassostrea gigas	102-108
33815292-3	2021	It is generally agreed that high sialylation, 2,3 sialic acid capping of terminal N-acetyl galactosamine or galactose leads to longer circulating half-life, by blocking binding of asialoglycoprotein receptor (ASGPR) in the liver.	N-Acetylneuraminic Acid	50-61	asialoglycoprotein receptor 1	Homo sapiens	180-207
33815292-3	2021	It is generally agreed that high sialylation, 2,3 sialic acid capping of terminal N-acetyl galactosamine or galactose leads to longer circulating half-life, by blocking binding of asialoglycoprotein receptor (ASGPR) in the liver.	N-Acetylneuraminic Acid	50-61	asialoglycoprotein receptor 1	Homo sapiens	209-214
1708619-2	1990	A common structural feature of N-CAM is the presence of homopolymers of alpha-2,8-linked sialic acid residues, which regulates the homophilic adhesive properties of N-CAM.	N-Acetylneuraminic Acid	89-100	neural cell adhesion molecule 1	Homo sapiens	31-36
1708619-2	1990	A common structural feature of N-CAM is the presence of homopolymers of alpha-2,8-linked sialic acid residues, which regulates the homophilic adhesive properties of N-CAM.	N-Acetylneuraminic Acid	89-100	neural cell adhesion molecule 1	Homo sapiens	165-170
33816461-15	2021	Our study indicates that molecules altering Cofilin function could significantly revert the cell migration defect due to GNE mutation in sialic acid-deficient cells.	N-Acetylneuraminic Acid	137-148	cofilin 1	Homo sapiens	44-51
33816461-15	2021	Our study indicates that molecules altering Cofilin function could significantly revert the cell migration defect due to GNE mutation in sialic acid-deficient cells.	N-Acetylneuraminic Acid	137-148	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	121-124
33589816-4	2021	In B cells, CD22 associated in a sialic acid-dependent manner with integrin beta7 on the cell surface to target intracellular Shp1 to beta7.	N-Acetylneuraminic Acid	33-44	CD22 molecule	Homo sapiens	12-16
33589816-4	2021	In B cells, CD22 associated in a sialic acid-dependent manner with integrin beta7 on the cell surface to target intracellular Shp1 to beta7.	N-Acetylneuraminic Acid	33-44	integrin subunit beta 7	Homo sapiens	67-81
33589816-4	2021	In B cells, CD22 associated in a sialic acid-dependent manner with integrin beta7 on the cell surface to target intracellular Shp1 to beta7.	N-Acetylneuraminic Acid	33-44	nuclear receptor subfamily 0 group B member 2	Homo sapiens	126-130
33589816-4	2021	In B cells, CD22 associated in a sialic acid-dependent manner with integrin beta7 on the cell surface to target intracellular Shp1 to beta7.	N-Acetylneuraminic Acid	33-44	immunoglobulin kappa variable 2D-24 (non-functional)	Homo sapiens	76-81
33234415-11	2021	HILIC method also showed that O-acetylation level of sialic acid residues might vary from one rEPO to the other.	N-Acetylneuraminic Acid	53-64	erythropoietin	Rattus norvegicus	94-98
19369701-1	2009	Human Siglec-14, a member of the Siglec family of sialic acid-binding lectins, shows extensive sequence similarity to human Siglec-5.	N-Acetylneuraminic Acid	50-61	sialic acid binding Ig like lectin 14	Homo sapiens	6-15
25863634-3	2015	Hence, the equilibrium uptake of Neu5Ac on a strong anion exchanger, AD-1 was investigated experimentally and theoretically.	N-Acetylneuraminic Acid	33-39	amyloid beta precursor protein	Homo sapiens	69-73
21178016-1	2011	CD22 is a member of the sialic acid-binding Ig-like lectin (Siglec) family that is known to be a regulator of B cell signaling.	N-Acetylneuraminic Acid	24-35	CD22 molecule	Homo sapiens	0-4
19369701-1	2009	Human Siglec-14, a member of the Siglec family of sialic acid-binding lectins, shows extensive sequence similarity to human Siglec-5.	N-Acetylneuraminic Acid	50-61	sialic acid binding Ig like lectin 5	Homo sapiens	124-132
34906672-2	2022	We herein report in vivo tumor suppression via an intravenously injected abiotic sialic acid (TCCSia) that could be metabolically incorporated into tumor cell surface to yield of a high affinity ligand (TCCSiaalpha2,3-Gal) of Siglec-1 specifically expressed on macrophages.	N-Acetylneuraminic Acid	81-92	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	226-234
7919351-7	1994	However, when Ser2, Thr3, and Thr4 carry O-linked sialooligosaccharides (normal GPA-M or -N), the MoAbs recognize Gly5- and sialic acid-dependent blood group M-related epitope.	N-Acetylneuraminic Acid	124-135	jagged canonical Notch ligand 2	Homo sapiens	14-18
18698493-5	2008	Neuraminidase treatment or knockdown by siRNA of uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc2-epimerase), which is a key enzyme of sialic acid biosynthesis, enhanced the amount of cell death induced by C6-ceramide in the highly sialylated 3G3 clone.	N-Acetylneuraminic Acid	151-162	neuraminidase 1	Homo sapiens	0-13
34324046-9	2022	Three substances including lactadherin, sialic acid and phospholipid, key components of MFGM were significantly positively correlated to Bifidobacterium of stool samples from infants, and stimulated the growth rate of Bifidobacterium significantly by provided energy in vitro growth experiment with RNA analysis.	N-Acetylneuraminic Acid	40-51	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	88-92
34878262-3	2022	The present study establishes that n-acetylneuraminic acid (Neu5ac) inhibits the amyloid fibrillation of hen egg-white lysozyme (HEWL) and alpha-synuclein (SYN), as observed using various biophysical techniques and cellular assays.	N-Acetylneuraminic Acid	35-58	synuclein alpha	Homo sapiens	139-154
34669428-6	2022	The data show that VP2 binds alpha2,3-linked SA with high affinity but also binds alpha2,6-linked SA.	N-Acetylneuraminic Acid	45-47	glycoprotein hormone subunit alpha 2	Homo sapiens	29-35
34669428-6	2022	The data show that VP2 binds alpha2,3-linked SA with high affinity but also binds alpha2,6-linked SA.	N-Acetylneuraminic Acid	98-100	glycoprotein hormone subunit alpha 2	Homo sapiens	82-88
34878262-3	2022	The present study establishes that n-acetylneuraminic acid (Neu5ac) inhibits the amyloid fibrillation of hen egg-white lysozyme (HEWL) and alpha-synuclein (SYN), as observed using various biophysical techniques and cellular assays.	N-Acetylneuraminic Acid	35-58	synemin	Homo sapiens	156-159
34878262-3	2022	The present study establishes that n-acetylneuraminic acid (Neu5ac) inhibits the amyloid fibrillation of hen egg-white lysozyme (HEWL) and alpha-synuclein (SYN), as observed using various biophysical techniques and cellular assays.	N-Acetylneuraminic Acid	60-66	synuclein alpha	Homo sapiens	139-154
34878262-3	2022	The present study establishes that n-acetylneuraminic acid (Neu5ac) inhibits the amyloid fibrillation of hen egg-white lysozyme (HEWL) and alpha-synuclein (SYN), as observed using various biophysical techniques and cellular assays.	N-Acetylneuraminic Acid	60-66	synemin	Homo sapiens	156-159
34878262-6	2022	Neu5ac stabilizes the states that facilitate the amyloid formation in HEWL and SYN, as demonstrated by an enhanced intrinsic fluorescence in its presence, which is further confirmed by an increase in Tm obtained from differential scanning calorimetry thermograms and an increase in the near-UV CD signal for HEWL with Neu5ac.	N-Acetylneuraminic Acid	0-6	synemin	Homo sapiens	79-82
34878262-6	2022	Neu5ac stabilizes the states that facilitate the amyloid formation in HEWL and SYN, as demonstrated by an enhanced intrinsic fluorescence in its presence, which is further confirmed by an increase in Tm obtained from differential scanning calorimetry thermograms and an increase in the near-UV CD signal for HEWL with Neu5ac.	N-Acetylneuraminic Acid	318-324	synemin	Homo sapiens	79-82
34813786-7	2022	These results could imply that an ancestral tunicate ST3Gal-I in C. savignyi would prefer O-glycan onto glycoproteins as its sialic acid acceptor than vertebrate enzymes.	N-Acetylneuraminic Acid	125-136	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	53-61
34555851-0	2021	Differential sialic acid content in adult and neonatal fibrinogen mediates differences in clot polymerization dynamics.	N-Acetylneuraminic Acid	13-24	fibrinogen beta chain	Homo sapiens	55-65
34857478-2	2022	Human Siglec-10 is a member of the sialic acid-binding immunoglobulin-type lectin (Siglec) family and a B cell surface coreceptor that inhibits B cell receptor-induced signalling.	N-Acetylneuraminic Acid	35-46	sialic acid binding Ig like lectin 10	Homo sapiens	6-15
34754101-2	2022	Here, we reveal that the receptor-binding domain (RBD) of the spike (S) protein on SARS-CoV-2 recognizes oligosaccharides containing sialic acid (Sia), with preference for monosialylated gangliosides.	N-Acetylneuraminic Acid	133-144	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	62-67
34754101-2	2022	Here, we reveal that the receptor-binding domain (RBD) of the spike (S) protein on SARS-CoV-2 recognizes oligosaccharides containing sialic acid (Sia), with preference for monosialylated gangliosides.	N-Acetylneuraminic Acid	133-144	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	69-70
34754101-2	2022	Here, we reveal that the receptor-binding domain (RBD) of the spike (S) protein on SARS-CoV-2 recognizes oligosaccharides containing sialic acid (Sia), with preference for monosialylated gangliosides.	N-Acetylneuraminic Acid	146-149	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	62-67
34754101-2	2022	Here, we reveal that the receptor-binding domain (RBD) of the spike (S) protein on SARS-CoV-2 recognizes oligosaccharides containing sialic acid (Sia), with preference for monosialylated gangliosides.	N-Acetylneuraminic Acid	146-149	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	69-70
34878295-8	2021	Intriguingly, by using quartz crystal microbalance, we demonstrated that the PSA purified from the parent strain interacted with human sialic acid-binding immunoglobulin-like lectins (Siglecs), including Siglec-5, Siglec-7, Siglec-11, and Siglec-14.	N-Acetylneuraminic Acid	135-146	sialic acid binding Ig like lectin 5	Homo sapiens	204-212
34878295-8	2021	Intriguingly, by using quartz crystal microbalance, we demonstrated that the PSA purified from the parent strain interacted with human sialic acid-binding immunoglobulin-like lectins (Siglecs), including Siglec-5, Siglec-7, Siglec-11, and Siglec-14.	N-Acetylneuraminic Acid	135-146	sialic acid binding Ig like lectin 7	Homo sapiens	214-222
34878295-8	2021	Intriguingly, by using quartz crystal microbalance, we demonstrated that the PSA purified from the parent strain interacted with human sialic acid-binding immunoglobulin-like lectins (Siglecs), including Siglec-5, Siglec-7, Siglec-11, and Siglec-14.	N-Acetylneuraminic Acid	135-146	sialic acid binding Ig like lectin 11	Homo sapiens	224-233
34878295-8	2021	Intriguingly, by using quartz crystal microbalance, we demonstrated that the PSA purified from the parent strain interacted with human sialic acid-binding immunoglobulin-like lectins (Siglecs), including Siglec-5, Siglec-7, Siglec-11, and Siglec-14.	N-Acetylneuraminic Acid	135-146	sialic acid binding Ig like lectin 14	Homo sapiens	239-248
34224569-1	2021	Among the enzymes of the biosynthesis of sialoglycoconjugates, UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE), catalyzing the first essential step of the sialic acid (Sia) de novo biosynthesis, and CMP-Sia synthase (CMAS), activating Sia to CMP-Sia, are particularly important.	N-Acetylneuraminic Acid	176-187	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	63-125
34224569-1	2021	Among the enzymes of the biosynthesis of sialoglycoconjugates, UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE), catalyzing the first essential step of the sialic acid (Sia) de novo biosynthesis, and CMP-Sia synthase (CMAS), activating Sia to CMP-Sia, are particularly important.	N-Acetylneuraminic Acid	176-187	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	127-130
34555851-1	2021	Neonates possess a molecular variant of fibrinogen, known as fetal fibrinogen, characterized by increased sialic acid, a greater negative charge, and decreased activity compared to adults.	N-Acetylneuraminic Acid	106-117	fibrinogen beta chain	Homo sapiens	40-50
34555851-1	2021	Neonates possess a molecular variant of fibrinogen, known as fetal fibrinogen, characterized by increased sialic acid, a greater negative charge, and decreased activity compared to adults.	N-Acetylneuraminic Acid	106-117	fibrinogen beta chain	Homo sapiens	67-77
34555851-5	2021	We hypothesized that the increased sialic acid content of neonatal fibrinogen promotes fibrin B:b knob hole interactions and consequently influences the structure and function of the neonatal fibrin matrix.	N-Acetylneuraminic Acid	35-46	fibrinogen beta chain	Homo sapiens	67-77
34555851-8	2021	We determined that sialic acid content of neonatal fibrinogen is a key determinant of resulting clot properties.	N-Acetylneuraminic Acid	19-30	fibrinogen beta chain	Homo sapiens	51-61
34960711-3	2021	Herein, we report that sialic acid (SA) can act as an attachment receptor for PDCoV invasion and facilitate its infection.	N-Acetylneuraminic Acid	23-34	acyl-CoA synthetase medium chain family member 3	Homo sapiens	36-38
34324649-4	2021	The O-glycan sialyltransferase St3gal1 add sialic acid specifically on the TF-antigen.	N-Acetylneuraminic Acid	43-54	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	31-38
34817551-6	2021	Neuraminidase treatment, which exposes excess NA2 by removing the terminal sialic acid of N-glycans, suppressed osteoclastogenesis and DC function.	N-Acetylneuraminic Acid	75-86	neuraminidase 1	Homo sapiens	0-13
34686894-0	2021	Apo-H (beta-2-glycoprotein) intact N-glycan analysis by MALDI-TOF-MS using sialic acid derivatization.	N-Acetylneuraminic Acid	75-86	apolipoprotein H	Homo sapiens	0-5
34787457-8	2022	Comparing wild type and sialic acid-deficient CHO cells, we show that the usage of CD46 is independent of its sialylation status.	N-Acetylneuraminic Acid	24-35	membrane cofactor protein	Cricetulus griseus	83-87
34523784-2	2021	The  in vivo  activity of EPO is carbohydrate-dependent with the number of sialic acid residues regulating its circulatory half-life.	N-Acetylneuraminic Acid	75-86	erythropoietin	Homo sapiens	26-29
34607125-2	2021	N-Acetylmannosamine-6-phosphate 2-epimerase is an enzyme in the bacterial sialic acid catabolic pathway.	N-Acetylneuraminic Acid	74-85	AT695_RS02205	Staphylococcus aureus	0-43
34406679-2	2021	Soluble polysialic acid with an average degree of polymerization 20 (polySia avDP20) prevents inflammation and oxidative burst in human macrophages via sialic acid-binding immunoglobulin like lectin-11 (SIGLEC11) receptor and interferes with alternative complement activation.	N-Acetylneuraminic Acid	152-163	sialic acid binding Ig like lectin 11	Homo sapiens	203-211
34510381-1	2021	UDP-N-Acetyl glucosamine-2 epimerase/N-acetyl mannosamine kinase (GNE) catalyzes key enzymatic reactions in the biosynthesis of sialic acid.	N-Acetylneuraminic Acid	128-139	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	13-64
34510381-1	2021	UDP-N-Acetyl glucosamine-2 epimerase/N-acetyl mannosamine kinase (GNE) catalyzes key enzymatic reactions in the biosynthesis of sialic acid.	N-Acetylneuraminic Acid	128-139	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	66-69
34510381-3	2021	However, recent studies propose alternate roles of GNE in other cellular processes beside sialic acid biosynthesis, particularly interaction of GNE with alpha-actinin 1 and 2.	N-Acetylneuraminic Acid	90-101	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	51-54
34510381-3	2021	However, recent studies propose alternate roles of GNE in other cellular processes beside sialic acid biosynthesis, particularly interaction of GNE with alpha-actinin 1 and 2.	N-Acetylneuraminic Acid	90-101	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Rattus norvegicus	144-147
34555215-6	2021	More than 200 mutations in key sialic acid biosynthetic enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) have been identified worldwide in the muscle biopsies of GNE myopathy patients.	N-Acetylneuraminic Acid	31-42	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	63-125
34555215-6	2021	More than 200 mutations in key sialic acid biosynthetic enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) have been identified worldwide in the muscle biopsies of GNE myopathy patients.	N-Acetylneuraminic Acid	31-42	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	127-130
34114711-2	2021	Cell lines can also differ in the presence of virus receptors, such as the sialic acid (Sia) receptors used by influenza A viruses (IAV), which can vary in linkage (alpha2,3- or alpha2,6-linkage) and form (N-glycolylneuraminic acid (Neu5Gc) or N-acetylneuraminic acid (Neu5Ac)).	N-Acetylneuraminic Acid	75-86	immunoglobulin kappa variable 2-24	Homo sapiens	165-173
34114711-2	2021	Cell lines can also differ in the presence of virus receptors, such as the sialic acid (Sia) receptors used by influenza A viruses (IAV), which can vary in linkage (alpha2,3- or alpha2,6-linkage) and form (N-glycolylneuraminic acid (Neu5Gc) or N-acetylneuraminic acid (Neu5Ac)).	N-Acetylneuraminic Acid	75-86	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	178-186
34752696-7	2021	To demonstrate the reliability of CoMMon, we applied the method to the neuraminidase-catalyzed cleavage of N-acetylneuraminic acid (Neu5Ac) residues from a series of glycoproteins of varying molecular weights and degrees of glycosylation.	N-Acetylneuraminic Acid	107-130	neuraminidase 1	Homo sapiens	71-84
34752696-7	2021	To demonstrate the reliability of CoMMon, we applied the method to the neuraminidase-catalyzed cleavage of N-acetylneuraminic acid (Neu5Ac) residues from a series of glycoproteins of varying molecular weights and degrees of glycosylation.	N-Acetylneuraminic Acid	132-138	neuraminidase 1	Homo sapiens	71-84
34888356-0	2021	Isomer-Specific Monitoring of Sialylated N-Glycans Reveals Association of alpha2,3-Linked Sialic Acid Epitope With Behcet"s Disease.	N-Acetylneuraminic Acid	90-101	immunoglobulin kappa variable 2-24	Homo sapiens	74-82
34192335-6	2021	The two genes that are responsible for regulating the level of acetylation on Neu5Ac, are Sialic acid acetylesterase (SIAE) and Sialic acid acetyltransferase (CASD1).	N-Acetylneuraminic Acid	78-84	sialic acid acetylesterase	Homo sapiens	90-116
34192335-6	2021	The two genes that are responsible for regulating the level of acetylation on Neu5Ac, are Sialic acid acetylesterase (SIAE) and Sialic acid acetyltransferase (CASD1).	N-Acetylneuraminic Acid	78-84	sialic acid acetylesterase	Homo sapiens	118-122
34192335-6	2021	The two genes that are responsible for regulating the level of acetylation on Neu5Ac, are Sialic acid acetylesterase (SIAE) and Sialic acid acetyltransferase (CASD1).	N-Acetylneuraminic Acid	78-84	CAS1 domain containing 1	Homo sapiens	159-164
34192335-6	2021	The two genes that are responsible for regulating the level of acetylation on Neu5Ac, are Sialic acid acetylesterase (SIAE) and Sialic acid acetyltransferase (CASD1).	N-Acetylneuraminic Acid	128-139	CAS1 domain containing 1	Homo sapiens	159-164
34830217-2	2021	In this study, MOS was activated at the terminal to obtain three different graft complexes modified with sialic acid moiety (MOS-Sia).	N-Acetylneuraminic Acid	105-116	Moloney sarcoma oncogene	Mus musculus	15-18
34830217-2	2021	In this study, MOS was activated at the terminal to obtain three different graft complexes modified with sialic acid moiety (MOS-Sia).	N-Acetylneuraminic Acid	105-116	Moloney sarcoma oncogene	Mus musculus	125-128
34858435-3	2021	Whole genome sequencing revealed the presence of two compound heterozygous variants in GNE encoding the enzyme UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase, crucial for sialic acid biosynthesis.	N-Acetylneuraminic Acid	188-199	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	87-90
34289026-2	2021	Here, we introduce sialic-acid-binding immunoglobulin-like lectin (Siglec)-6 as a novel target for CAR T-cells in AML.	N-Acetylneuraminic Acid	19-30	nuclear receptor subfamily 1, group I, member 3	Mus musculus	99-102
34762717-2	2021	Siglec-9 restrains NK cytotoxicity by binding to sialoglycans (sialic acid-containing glycans) on target cells.	N-Acetylneuraminic Acid	63-74	sialic acid binding Ig like lectin 9	Homo sapiens	0-8
34858435-5	2021	Furthermore, sialic acid constitutes a key ligand for complement factor H (FH), an important inhibitor of the complement system, protecting host cells from indiscriminate attack.	N-Acetylneuraminic Acid	13-24	complement factor H	Homo sapiens	65-73
34858435-5	2021	Furthermore, sialic acid constitutes a key ligand for complement factor H (FH), an important inhibitor of the complement system, protecting host cells from indiscriminate attack.	N-Acetylneuraminic Acid	13-24	complement factor H	Homo sapiens	75-77
34634204-3	2021	Herein, we develop a prototype flow-through device (related, but distinct to LFDs), utilizing N-acetyl neuraminic acid-functionalized, polymer-coated, gold nanoparticles as the detection/capture unit for SARS-COV-2, by targeting the sialic acid-binding site of the spike protein.	N-Acetylneuraminic Acid	94-118	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	265-270
34355537-5	2021	In our study we tested sialic acid enriched species from a chimeric murine/human kappa light chain IgG1 (mAb1) with known FcgammaRIIIa binding and ADCC activities.	N-Acetylneuraminic Acid	23-34	Fc gamma receptor IIIa	Homo sapiens	122-134
34676965-3	2021	Although GNE, which is the mutated gene responsible for the disease, is well known as the key enzyme in the biosynthesis pathway of sialic acid, the clinicopathological-genetic spectrum of GNE mutant patients is still unclear and expanding.	N-Acetylneuraminic Acid	132-143	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	9-12
34676965-3	2021	Although GNE, which is the mutated gene responsible for the disease, is well known as the key enzyme in the biosynthesis pathway of sialic acid, the clinicopathological-genetic spectrum of GNE mutant patients is still unclear and expanding.	N-Acetylneuraminic Acid	132-143	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	189-192
34587757-1	2021	OBJECTIVE: Species-specific pseudogenization of the CMAH gene during human evolution eliminated common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) biosynthesis from its precursor N-acetylneuraminic acid (Neu5Ac).	N-Acetylneuraminic Acid	192-215	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	52-56
34587757-1	2021	OBJECTIVE: Species-specific pseudogenization of the CMAH gene during human evolution eliminated common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) biosynthesis from its precursor N-acetylneuraminic acid (Neu5Ac).	N-Acetylneuraminic Acid	217-223	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	52-56
34587757-7	2021	Remarkably, feeding Neu5Ac-enriched high-fat diet alone has a substantial intrinsic protective effect against atherosclerosis in Ldlr-/- mice even in the absence of dietary Neu5Gc but only in the human-like Cmah-null background.	N-Acetylneuraminic Acid	20-26	low density lipoprotein receptor	Mus musculus	129-133
34289079-4	2021	Here, we show a mathematical modeling-guided approach to 3"-sialyllactose (3SL) synthesis from N-acetyl-D-neuraminic acid (Neu5Ac) and lactose in the presence of CTP, via the reactions of CMP-Neu5Ac synthetase and alpha2,3-sialyltransferase.	N-Acetylneuraminic Acid	95-121	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	188-209
34289079-4	2021	Here, we show a mathematical modeling-guided approach to 3"-sialyllactose (3SL) synthesis from N-acetyl-D-neuraminic acid (Neu5Ac) and lactose in the presence of CTP, via the reactions of CMP-Neu5Ac synthetase and alpha2,3-sialyltransferase.	N-Acetylneuraminic Acid	123-129	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	188-209
34634204-3	2021	Herein, we develop a prototype flow-through device (related, but distinct to LFDs), utilizing N-acetyl neuraminic acid-functionalized, polymer-coated, gold nanoparticles as the detection/capture unit for SARS-COV-2, by targeting the sialic acid-binding site of the spike protein.	N-Acetylneuraminic Acid	233-244	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	265-270
34667062-0	2021	Prenatal hydrops fetalis associated with infantile free sialic acid storage disease due to a novel homozygous deletion in the SLC17A5 gene.	N-Acetylneuraminic Acid	56-67	solute carrier family 17 member 5	Homo sapiens	126-133
34461439-6	2021	Liquid chromatography with tandem mass spectrometry revealed that two glycopeptides of transferrin receptor protein 1 (TFR1) containing N-acetylhexosamine-sialic acid were not detected in ST6GALNACIII-depleted A549 cells compared with control cells.	N-Acetylneuraminic Acid	155-166	transferrin receptor	Homo sapiens	87-117
34461439-6	2021	Liquid chromatography with tandem mass spectrometry revealed that two glycopeptides of transferrin receptor protein 1 (TFR1) containing N-acetylhexosamine-sialic acid were not detected in ST6GALNACIII-depleted A549 cells compared with control cells.	N-Acetylneuraminic Acid	155-166	transferrin receptor	Homo sapiens	119-123
34667062-4	2021	ISSD is caused by mutations in SLC17A5 (OMIM #604322), which encodes sialin, a lysosomal-membrane sialic acid transporter.	N-Acetylneuraminic Acid	98-109	solute carrier family 17 member 5	Homo sapiens	31-38
34664930-3	2021	Cytotoxic ribonuclease A (RNase A) was effectively caged in the matrix of disulfide-hybridized silica NPs (encapsulation efficiency of ~64%), which were further functionalized with cancer targeting capability via surface imprinting with SA as imprinting template.	N-Acetylneuraminic Acid	237-239	ribonuclease A family member 1, pancreatic	Homo sapiens	26-33
34562778-1	2021	Transferrin is a glycoprotein containing two bi- or tri-antennary carbohydrate chains ending with sialic acid.	N-Acetylneuraminic Acid	98-109	transferrin	Homo sapiens	0-11
34664930-5	2021	In vitro experiments confirmed that the SA-imprinted RNase A@BS-NPs could selectively target SA-overexpressed tumor cells, promote cells uptake, and subsequently be cleaved by intracellular glutathione (GSH), resulting in rapid release kinetics and enhanced cell cytotoxicity.	N-Acetylneuraminic Acid	40-42	ribonuclease A family member 1, pancreatic	Homo sapiens	53-60
34664930-5	2021	In vitro experiments confirmed that the SA-imprinted RNase A@BS-NPs could selectively target SA-overexpressed tumor cells, promote cells uptake, and subsequently be cleaved by intracellular glutathione (GSH), resulting in rapid release kinetics and enhanced cell cytotoxicity.	N-Acetylneuraminic Acid	93-95	ribonuclease A family member 1, pancreatic	Homo sapiens	53-60
34339869-2	2021	L-selectin and Siglec-1, receptors for sialic acid (SA), are highly expressed in circulating neutrophils and monocytes, respectively, in tumor-bearing mice, and N/Ms are recruited to tumors in response to inflammatory cytokines secreted by the TME, promoting tumor growth and invasion.	N-Acetylneuraminic Acid	39-50	selectin, lymphocyte	Mus musculus	0-10
34339869-2	2021	L-selectin and Siglec-1, receptors for sialic acid (SA), are highly expressed in circulating neutrophils and monocytes, respectively, in tumor-bearing mice, and N/Ms are recruited to tumors in response to inflammatory cytokines secreted by the TME, promoting tumor growth and invasion.	N-Acetylneuraminic Acid	39-50	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	15-23
34339869-2	2021	L-selectin and Siglec-1, receptors for sialic acid (SA), are highly expressed in circulating neutrophils and monocytes, respectively, in tumor-bearing mice, and N/Ms are recruited to tumors in response to inflammatory cytokines secreted by the TME, promoting tumor growth and invasion.	N-Acetylneuraminic Acid	52-54	selectin, lymphocyte	Mus musculus	0-10
34339869-2	2021	L-selectin and Siglec-1, receptors for sialic acid (SA), are highly expressed in circulating neutrophils and monocytes, respectively, in tumor-bearing mice, and N/Ms are recruited to tumors in response to inflammatory cytokines secreted by the TME, promoting tumor growth and invasion.	N-Acetylneuraminic Acid	52-54	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	15-23
34659241-6	2021	animalis interacts with Siglecs (sialic acid-binding immunoglobulin-like lectins) expressed on innate immune cells with highest binding to Siglec-7.	N-Acetylneuraminic Acid	33-44	sialic acid binding Ig like lectin 7	Homo sapiens	139-147
34584952-0	2021	Sialic Acid Ligands of CD28 Suppress Costimulation of T Cells.	N-Acetylneuraminic Acid	0-11	CD28 molecule	Homo sapiens	23-27
34641504-0	2021	A Possible Inhibitory Role of Sialic Acid on MUC1 in Peritoneal Dissemination of Clear Cell-Type Ovarian Cancer Cells.	N-Acetylneuraminic Acid	30-41	mucin 1, cell surface associated	Homo sapiens	45-49
34641504-7	2021	Therefore, sialic acid linked to MUC1 in the form, at least in part, of sialyl-T, as shown to be recognized by monoclonal antibody MY.1E12, is responsible for the suppression of adhesion of these cells to mesothelial cells and the suppression of peritoneal implantation and dissemination.	N-Acetylneuraminic Acid	11-22	mucin 1, transmembrane	Mus musculus	33-37
34415814-3	2021	We demonstrated that human eosinophils express alpha2,6- and alpha2,3-linked sialic acid, and drastically reduced influenza virus titer.	N-Acetylneuraminic Acid	77-88	glycoprotein hormone subunit alpha 2	Homo sapiens	47-69
34631661-0	2021	A Linkage-specific Sialic Acid Labeling Strategy Reveals Different Site-specific Glycosylation Patterns in SARS-CoV-2 Spike Protein Produced in CHO and HEK Cell Substrates.	N-Acetylneuraminic Acid	19-30	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	118-123
34603453-0	2021	Neu5Ac Induces Human Dental Pulp Stem Cell Osteo-/Odontoblastic Differentiation by Enhancing MAPK/ERK Pathway Activation.	N-Acetylneuraminic Acid	0-6	mitogen-activated protein kinase 1	Homo sapiens	98-101
34603453-6	2021	Following the treatment of different concentrations of Neu5Ac and removing sialic acid from the cell surface by neuraminidase, the osteo-/odontoblastic differentiation of these cells was evaluated via mineralization, alkaline phosphatase, and in vivo assays.	N-Acetylneuraminic Acid	75-86	neuraminidase 1	Homo sapiens	112-125
34603453-9	2021	The existence of sialic acid on the DPSC membrane was confirmed by fluorescent microscopy, and the ability of osteo-/odontoblastic differentiation was decreased after removing sialic acid by neuraminidase.	N-Acetylneuraminic Acid	17-28	neuraminidase 1	Homo sapiens	191-204
34603453-9	2021	The existence of sialic acid on the DPSC membrane was confirmed by fluorescent microscopy, and the ability of osteo-/odontoblastic differentiation was decreased after removing sialic acid by neuraminidase.	N-Acetylneuraminic Acid	176-187	neuraminidase 1	Homo sapiens	191-204
34603453-13	2021	Furthermore, Neu5Ac treatment enhanced p-ERK expression in DPSCs, while ERK pathway inhibition disrupted the ability of Neu5Ac to enhance the osteo-/odontoblastic differentiation of these cells.	N-Acetylneuraminic Acid	13-19	mitogen-activated protein kinase 1	Homo sapiens	41-44
34603453-13	2021	Furthermore, Neu5Ac treatment enhanced p-ERK expression in DPSCs, while ERK pathway inhibition disrupted the ability of Neu5Ac to enhance the osteo-/odontoblastic differentiation of these cells.	N-Acetylneuraminic Acid	120-126	mitogen-activated protein kinase 1	Homo sapiens	72-75
34603453-15	2021	Neu5Ac can promote DPSC osteo-/odontoblastic differentiation through a process associated with the modulation of the ERK signaling pathway activity.	N-Acetylneuraminic Acid	0-6	mitogen-activated protein kinase 1	Homo sapiens	117-120
34584952-3	2021	Here, we report that sialic acid-containing glycans on the surface of both T cells and APCs are alternative ligands of CD28 that compete with binding to its well-documented activatory ligand CD80 on the APC, resulting in attenuated costimulation.	N-Acetylneuraminic Acid	21-32	amyloid P component, serum	Homo sapiens	87-91
34584952-3	2021	Here, we report that sialic acid-containing glycans on the surface of both T cells and APCs are alternative ligands of CD28 that compete with binding to its well-documented activatory ligand CD80 on the APC, resulting in attenuated costimulation.	N-Acetylneuraminic Acid	21-32	CD28 molecule	Homo sapiens	119-123
34584952-3	2021	Here, we report that sialic acid-containing glycans on the surface of both T cells and APCs are alternative ligands of CD28 that compete with binding to its well-documented activatory ligand CD80 on the APC, resulting in attenuated costimulation.	N-Acetylneuraminic Acid	21-32	CD80 molecule	Homo sapiens	191-195
34584952-6	2021	These results reveal a previously unrecognized role of sialic acid ligands in attenuation of CD28-mediated costimulation of T cells.	N-Acetylneuraminic Acid	55-66	CD28 molecule	Homo sapiens	93-97
34611562-5	2021	The molar absorption coefficients in the near-UV region for the native and desialylated apo-transferrin differ by several percent, suggesting a subtle dependence of the glycoprotein absorbance on the variable sialic acid content.	N-Acetylneuraminic Acid	209-220	transferrin	Homo sapiens	92-103
34343291-3	2021	One such example is the development of insulin resistance, which has been attributed to the removal of sialic acid residues from N-glycans of insulin receptor (IR) from various experimental studies.	N-Acetylneuraminic Acid	103-114	insulin	Homo sapiens	39-46
34343291-3	2021	One such example is the development of insulin resistance, which has been attributed to the removal of sialic acid residues from N-glycans of insulin receptor (IR) from various experimental studies.	N-Acetylneuraminic Acid	103-114	insulin receptor	Homo sapiens	142-158
34343291-3	2021	One such example is the development of insulin resistance, which has been attributed to the removal of sialic acid residues from N-glycans of insulin receptor (IR) from various experimental studies.	N-Acetylneuraminic Acid	103-114	insulin receptor	Homo sapiens	160-162
34577144-2	2021	These substances operate by specifically inhibiting sialyltransferase-mediated hypersialylation of cell surface glycoproteins or glycolipids, which then blocks the sialic acid recognition pathway and leads to deterioration of cell motility and invasion.	N-Acetylneuraminic Acid	164-175	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	52-69
34533554-3	2021	Here, a near-infrared (NIR) light activated fluorescence resonance energy transfer (FRET) strategy for the efficient and reliable simultaneous dual imaging of the mucin 1 (MUC1) protein backbone and MUC1-specific sialic acid (Sia) is reported.	N-Acetylneuraminic Acid	213-224	mucin 1, cell surface associated	Homo sapiens	199-203
34328657-7	2021	Removal of the sialic acid residues from CD44 resulted in suppressed interaction between Siglec-15 and CD44.	N-Acetylneuraminic Acid	15-26	CD44 molecule (Indian blood group)	Homo sapiens	41-45
34532629-5	2021	The sialic acid content of VWF was investigated using a modified ELISA to measure elderberry bark lectin, specific for sialic acid residues, binding to VWF.	N-Acetylneuraminic Acid	4-15	von Willebrand factor	Homo sapiens	27-30
34532629-5	2021	The sialic acid content of VWF was investigated using a modified ELISA to measure elderberry bark lectin, specific for sialic acid residues, binding to VWF.	N-Acetylneuraminic Acid	119-130	von Willebrand factor	Homo sapiens	152-155
34532629-9	2021	Finally, higher VWF levels in severely ill patients were correlated with lower VWF sialic acid content.	N-Acetylneuraminic Acid	83-94	von Willebrand factor	Homo sapiens	16-19
34532629-9	2021	Finally, higher VWF levels in severely ill patients were correlated with lower VWF sialic acid content.	N-Acetylneuraminic Acid	83-94	von Willebrand factor	Homo sapiens	79-82
34532629-11	2021	Lower VWF sialic acid content represents altered VWF processing and further confirms the disturbance caused to the endothelium in COVID-19.	N-Acetylneuraminic Acid	10-21	von Willebrand factor	Homo sapiens	6-9
34532629-11	2021	Lower VWF sialic acid content represents altered VWF processing and further confirms the disturbance caused to the endothelium in COVID-19.	N-Acetylneuraminic Acid	10-21	von Willebrand factor	Homo sapiens	49-52
34273862-1	2021	Polysialic acid (polySia), a homopolymer of alpha2,8-linked sialic acid residues, modifies a small number of proteins and has central functions in vertebrate signalling.	N-Acetylneuraminic Acid	60-71	immunoglobulin kappa variable 2-19 (pseudogene)	Homo sapiens	44-52
34328657-7	2021	Removal of the sialic acid residues from CD44 resulted in suppressed interaction between Siglec-15 and CD44.	N-Acetylneuraminic Acid	15-26	sialic acid binding Ig like lectin 15	Homo sapiens	89-98
34328657-7	2021	Removal of the sialic acid residues from CD44 resulted in suppressed interaction between Siglec-15 and CD44.	N-Acetylneuraminic Acid	15-26	CD44 molecule (Indian blood group)	Homo sapiens	103-107
34258226-0	2021	The fate of orally administered sialic acid: First insights from patients with N-acetylneuraminic acid synthase deficiency and control subjects.	N-Acetylneuraminic Acid	32-43	N-acetylneuraminate synthase	Homo sapiens	79-111
34539981-1	2021	CD169/Siglec1/sialoadhesin, a sialic acid-binding immunoglobulin-like lectin, is mainly expressed in metallophilic macrophages in the marginal zone of the spleen and in macrophages in the subcapsular sinus and medulla of lymph nodes.	N-Acetylneuraminic Acid	30-41	sialic acid binding Ig like lectin 1	Homo sapiens	0-5
34539981-1	2021	CD169/Siglec1/sialoadhesin, a sialic acid-binding immunoglobulin-like lectin, is mainly expressed in metallophilic macrophages in the marginal zone of the spleen and in macrophages in the subcapsular sinus and medulla of lymph nodes.	N-Acetylneuraminic Acid	30-41	sialic acid binding Ig like lectin 1	Homo sapiens	6-13
34539981-1	2021	CD169/Siglec1/sialoadhesin, a sialic acid-binding immunoglobulin-like lectin, is mainly expressed in metallophilic macrophages in the marginal zone of the spleen and in macrophages in the subcapsular sinus and medulla of lymph nodes.	N-Acetylneuraminic Acid	30-41	sialic acid binding Ig like lectin 1	Homo sapiens	14-26
34369311-0	2021	N1 neuraminidase of H5N1 avian influenza A virus complexed with sialic acid and zanamivir - A study by molecular docking and molecular dynamics simulation.	N-Acetylneuraminic Acid	64-75	neuraminidase 1	Homo sapiens	3-16
34273351-1	2021	CD22 belongs to the sialic acid-binding immunoglobulin-like lectins (Siglecs) family of receptors that is expressed on the surface of B cells.	N-Acetylneuraminic Acid	20-31	CD22 molecule	Homo sapiens	0-4
34330755-6	2021	Interestingly, GC B cells downregulate sialic acid forms that serve as high-affinity ligands for CD22, indicating a role for CD22 ligand binding during GC responses.	N-Acetylneuraminic Acid	39-50	CD22 antigen	Mus musculus	97-101
34330755-6	2021	Interestingly, GC B cells downregulate sialic acid forms that serve as high-affinity ligands for CD22, indicating a role for CD22 ligand binding during GC responses.	N-Acetylneuraminic Acid	39-50	CD22 antigen	Mus musculus	125-129
34294193-1	2021	Humans cannot synthesize the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an inactivating deletion in the cytidine-5"-monophospho-(CMP)-N-acetylneuraminic acid hydroxylase (CMAH) gene responsible for its synthesis.	N-Acetylneuraminic Acid	46-57	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	136-201
34294193-1	2021	Humans cannot synthesize the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc) because of an inactivating deletion in the cytidine-5"-monophospho-(CMP)-N-acetylneuraminic acid hydroxylase (CMAH) gene responsible for its synthesis.	N-Acetylneuraminic Acid	46-57	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	203-207
34157397-8	2021	Finally, in the diethylnitrosamine (DEN)-induced HCC murine model, the expression levels of NR4A2, p-RXRalpha, ST6Gal-I, and alpha2,6-linked sialic acid decreased in parallel in Cav-1-/- mice compared with Cav-1+/+ mice, which was consistent with the above in vitro results.	N-Acetylneuraminic Acid	141-152	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	125-131
34157397-8	2021	Finally, in the diethylnitrosamine (DEN)-induced HCC murine model, the expression levels of NR4A2, p-RXRalpha, ST6Gal-I, and alpha2,6-linked sialic acid decreased in parallel in Cav-1-/- mice compared with Cav-1+/+ mice, which was consistent with the above in vitro results.	N-Acetylneuraminic Acid	141-152	caveolin 1, caveolae protein	Mus musculus	178-183
34157397-8	2021	Finally, in the diethylnitrosamine (DEN)-induced HCC murine model, the expression levels of NR4A2, p-RXRalpha, ST6Gal-I, and alpha2,6-linked sialic acid decreased in parallel in Cav-1-/- mice compared with Cav-1+/+ mice, which was consistent with the above in vitro results.	N-Acetylneuraminic Acid	141-152	caveolin 1, caveolae protein	Mus musculus	206-211
34368076-7	2021	To address this question, we took N-Acetylneuraminic acid (Neu5Ac), a type of predominant sialic acid found in human cells, as the molecular probe to computationally search the surface of the spike protein to locate the potential binding sites of Neu5Ac.	N-Acetylneuraminic Acid	34-57	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	192-197
34368076-7	2021	To address this question, we took N-Acetylneuraminic acid (Neu5Ac), a type of predominant sialic acid found in human cells, as the molecular probe to computationally search the surface of the spike protein to locate the potential binding sites of Neu5Ac.	N-Acetylneuraminic Acid	59-65	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	192-197
34368076-7	2021	To address this question, we took N-Acetylneuraminic acid (Neu5Ac), a type of predominant sialic acid found in human cells, as the molecular probe to computationally search the surface of the spike protein to locate the potential binding sites of Neu5Ac.	N-Acetylneuraminic Acid	90-101	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	192-197
34368076-7	2021	To address this question, we took N-Acetylneuraminic acid (Neu5Ac), a type of predominant sialic acid found in human cells, as the molecular probe to computationally search the surface of the spike protein to locate the potential binding sites of Neu5Ac.	N-Acetylneuraminic Acid	247-253	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	192-197
34258226-1	2021	Background: In NANS deficiency, biallelic mutations in the N-acetylneuraminic acid synthase (NANS) gene impair the endogenous synthesis of sialic acid (N-acetylneuraminic acid) leading to accumulation of the precursor, N-acetyl mannosamine (ManNAc), and to a multisystemic disorder with intellectual disability.	N-Acetylneuraminic Acid	139-150	N-acetylneuraminate synthase	Homo sapiens	59-91
34258226-1	2021	Background: In NANS deficiency, biallelic mutations in the N-acetylneuraminic acid synthase (NANS) gene impair the endogenous synthesis of sialic acid (N-acetylneuraminic acid) leading to accumulation of the precursor, N-acetyl mannosamine (ManNAc), and to a multisystemic disorder with intellectual disability.	N-Acetylneuraminic Acid	139-150	N-acetylneuraminate synthase	Homo sapiens	93-97
34258226-1	2021	Background: In NANS deficiency, biallelic mutations in the N-acetylneuraminic acid synthase (NANS) gene impair the endogenous synthesis of sialic acid (N-acetylneuraminic acid) leading to accumulation of the precursor, N-acetyl mannosamine (ManNAc), and to a multisystemic disorder with intellectual disability.	N-Acetylneuraminic Acid	152-175	N-acetylneuraminate synthase	Homo sapiens	59-91
34258226-1	2021	Background: In NANS deficiency, biallelic mutations in the N-acetylneuraminic acid synthase (NANS) gene impair the endogenous synthesis of sialic acid (N-acetylneuraminic acid) leading to accumulation of the precursor, N-acetyl mannosamine (ManNAc), and to a multisystemic disorder with intellectual disability.	N-Acetylneuraminic Acid	152-175	N-acetylneuraminate synthase	Homo sapiens	93-97
34163424-1	2021	Background: NANS-CDG is a recently described congenital disorder of glycosylation caused by biallelic genetic variants in NANS, encoding an essential enzyme in de novo sialic acid synthesis.	N-Acetylneuraminic Acid	168-179	N-acetylneuraminate synthase	Homo sapiens	122-126
34179095-4	2021	Our results indicate that SARS-CoV-2 uses a dual strategy: in addition to the known interaction with angiotensin-converting enzyme 2, the viral spike protein can also interact with sialic-acid receptors of the cells in the upper airways.	N-Acetylneuraminic Acid	181-192	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	144-149
34100302-0	2021	Low vitamin B12 level in relation to trace element, total sialic acid and antioxidant enzymes in children with vitamin B12 deficiency anemia.	N-Acetylneuraminic Acid	58-69	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	12-15
34085814-7	2021	After demonstrating >=300% signal enhancements on model monosaccharides, these experiments were applied at 1 GHz to elucidate the structural network adopted by a sialic acid homotetramer, used as a model for alpha,2-8 linked polysaccharides.	N-Acetylneuraminic Acid	162-173	immunoglobulin kappa variable 2-19 (pseudogene)	Homo sapiens	208-217
34386965-4	2021	GALA peptides not only enhance specific uptake in APCs through binding to sialic acid moieties, they also facilitate the endosomal escape of mRNA especially in dendritic cells (DCs).	N-Acetylneuraminic Acid	74-85	galactosidase alpha	Homo sapiens	0-4
34200006-0	2021	CMAS and ST3GAL4 Play an Important Role in the Adsorption of Influenza Virus by Affecting the Synthesis of Sialic Acid Receptors.	N-Acetylneuraminic Acid	107-118	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	0-4
34200006-0	2021	CMAS and ST3GAL4 Play an Important Role in the Adsorption of Influenza Virus by Affecting the Synthesis of Sialic Acid Receptors.	N-Acetylneuraminic Acid	107-118	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	9-16
34200006-4	2021	Loss of CMAS and ST3GAL4 hindered the synthesis of sialic acid receptors, which in turn prevented the adsorption of IAV.	N-Acetylneuraminic Acid	51-62	cytidine monophosphate N-acetylneuraminic acid synthetase	Sus scrofa	8-12
34200006-4	2021	Loss of CMAS and ST3GAL4 hindered the synthesis of sialic acid receptors, which in turn prevented the adsorption of IAV.	N-Acetylneuraminic Acid	51-62	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Sus scrofa	17-24
34069698-0	2021	Knockout of the CMP-Sialic Acid Transporter SLC35A1 in Human Cell Lines Increases Transduction Efficiency of Adeno-Associated Virus 9: Implications for Gene Therapy Potency Assays.	N-Acetylneuraminic Acid	20-31	solute carrier family 35 member A1	Homo sapiens	44-51
35398442-1	2022	UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE) is a bifunctional enzyme (N-terminal epimerase and C-terminal Kinase domain) that catalyses the rate limiting step in sialic acid biosynthesis.	N-Acetylneuraminic Acid	161-172	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	38-41
35513096-0	2022	N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis.	N-Acetylneuraminic Acid	0-23	CD44 molecule (Indian blood group)	Homo sapiens	137-141
35513096-10	2022	Then, micelles with N-Acetylneuraminic acid and Chondroitin sulfate were prepared to load rapamycin(RAP).	N-Acetylneuraminic Acid	20-43	LDL receptor related protein associated protein 1	Homo sapiens	100-103
35219175-2	2022	In the present study, we identified and overexpressed genes capable of increasing sialic acid levels in CTLA4-Ig to develop cell lines using glycoengineering technology.	N-Acetylneuraminic Acid	82-93	cytotoxic T-lymphocyte protein 4	Cricetulus griseus	104-109
35294004-7	2022	Further analysis in a small panel of patients found the levels of N-acetylneuraminic acid and neuraminidase (dominantly the NEU3 isoform) were elevated in the hospitalized COVID-19 subjects and recovered at the 1-month post-infection stage, suggesting increasing desialylation in COVID-19 patients.	N-Acetylneuraminic Acid	66-89	neuraminidase 3	Homo sapiens	124-128
35487178-2	2022	The human N-acetylneuraminate pyruvate lyase (NPL) interconverts sialic acid to N-acetylmannosamine and pyruvate, and mutations of the NPL gene were found to cause sialuria and impair the functionality of muscles.	N-Acetylneuraminic Acid	65-76	N-acetylneuraminate pyruvate lyase	Homo sapiens	10-44
35487178-2	2022	The human N-acetylneuraminate pyruvate lyase (NPL) interconverts sialic acid to N-acetylmannosamine and pyruvate, and mutations of the NPL gene were found to cause sialuria and impair the functionality of muscles.	N-Acetylneuraminic Acid	65-76	N-acetylneuraminate pyruvate lyase	Homo sapiens	46-49
35487178-2	2022	The human N-acetylneuraminate pyruvate lyase (NPL) interconverts sialic acid to N-acetylmannosamine and pyruvate, and mutations of the NPL gene were found to cause sialuria and impair the functionality of muscles.	N-Acetylneuraminic Acid	65-76	N-acetylneuraminate pyruvate lyase	Homo sapiens	135-138
35367830-4	2022	Here, we found that Siglec-7, mainly expressed on hematopoietic cells, binds to VZV envelope glycoprotein B in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	113-124	sialic acid binding Ig like lectin 7	Homo sapiens	20-28
35367830-4	2022	Here, we found that Siglec-7, mainly expressed on hematopoietic cells, binds to VZV envelope glycoprotein B in a sialic acid-dependent manner.	N-Acetylneuraminic Acid	113-124	envelope glycoprotein B	Human alphaherpesvirus 3	84-107
35628640-10	2022	TNFalpha production inversely correlates with the relative intensities of the G0 glycoform, which lacks galactose and terminal sialic acid moieties.	N-Acetylneuraminic Acid	127-138	tumor necrosis factor	Homo sapiens	0-8
35460750-4	2022	Moreover, ACP not only restored HFD-induced gut disorder, as indicated by the depletion of Desulfovibrio and Oscillibacter and the enrichment of the Bacteroides, Parabacteroides, Butyricimonas, and Dubosiella, but also positively regulated gut metabolites such as solavetivone and N-acetylneuraminic acid.	N-Acetylneuraminic Acid	281-304	vitamin A enhanced cleft palate	Mus musculus	10-13
35272171-3	2022	We hypothesized that removal of sialic acid moieties on immature DCs (iDCs) could significantly affect DC-CSC-antigen loading, thereby leading to DC maturation and improving immune recognition and activity.	N-Acetylneuraminic Acid	32-43	decorin	Mus musculus	103-105
35272171-3	2022	We hypothesized that removal of sialic acid moieties on immature DCs (iDCs) could significantly affect DC-CSC-antigen loading, thereby leading to DC maturation and improving immune recognition and activity.	N-Acetylneuraminic Acid	32-43	decorin	Mus musculus	146-148
35272171-10	2022	This study reveals for the first time that sialic acid removal and loading with CSC antigens induces significant molecular, morphological, and functional changes in DCs and that this new DC identity may be considered for future combined immunotherapy strategies against breast tumors.	N-Acetylneuraminic Acid	43-54	decorin	Mus musculus	187-189
35467785-10	2022	In contrast, sialic acid was removed from PS+ and CD41+ PMP, which specifically lost alpha-2,3-linked sialic acid during platelet storage.	N-Acetylneuraminic Acid	13-24	glycoprotein hormone subunit alpha 2	Homo sapiens	85-92
35467785-10	2022	In contrast, sialic acid was removed from PS+ and CD41+ PMP, which specifically lost alpha-2,3-linked sialic acid during platelet storage.	N-Acetylneuraminic Acid	102-113	integrin subunit alpha 2b	Homo sapiens	50-54
35467785-10	2022	In contrast, sialic acid was removed from PS+ and CD41+ PMP, which specifically lost alpha-2,3-linked sialic acid during platelet storage.	N-Acetylneuraminic Acid	102-113	glycoprotein hormone subunit alpha 2	Homo sapiens	85-92
35524895-1	2022	Mutations in the sialic acid biosynthesis enzyme GNE lead to a late-onset, debilitating neuromuscular disorder, GNE myopathy, characterized by progressive skeletal muscle weakness.	N-Acetylneuraminic Acid	17-28	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	49-52
35581157-1	2022	Bifidobacterium bifidum possesses two extracellular sialidases (SiaBb1 and SiaBb2) that release free sialic acid from mucin sialoglycans, which can be utilized via cross-feeding by Bifidobacterium breve that, otherwise, is prevented from utilizing this nutrient source.	N-Acetylneuraminic Acid	101-112	mucin 1, cell surface associated	Bos taurus	118-123
35581157-5	2022	Pre-treatment of mucin secreted from bovine submaxillary glands (BSM) using His6 -tagged-Est and -SiaBb2 released a higher amount of sialic acid compared to the pre-treatment by His6 -SiaBb2.	N-Acetylneuraminic Acid	133-144	mucin 1, cell surface associated	Bos taurus	17-22
35581157-7	2022	These results indicate that the esterase activity of the SiaBb1 Est domain enhances the efficiency of SiaBb2 to cleave sialic acid from mucin.	N-Acetylneuraminic Acid	119-130	mucin 1, cell surface associated	Bos taurus	136-141
35247653-1	2022	NeuroEPO plus is a recently developed recombinant human erythropoietin (rhEPO) without erythropoietic activity and shorter plasma half-life due to its low sialic acid content.	N-Acetylneuraminic Acid	155-166	erythropoietin	Homo sapiens	56-70
35180825-6	2022	The Victoria lineage has shown the ability to bind to cell receptors with sialic acid residues at the alpha-2,3 and alpha-2,6 positions; whereas the Yamagata lineage does so exclusively in the human alpha-2,6 positions of the respiratory tract.	N-Acetylneuraminic Acid	74-85	glycoprotein hormone subunit alpha 2	Homo sapiens	102-109
35180825-6	2022	The Victoria lineage has shown the ability to bind to cell receptors with sialic acid residues at the alpha-2,3 and alpha-2,6 positions; whereas the Yamagata lineage does so exclusively in the human alpha-2,6 positions of the respiratory tract.	N-Acetylneuraminic Acid	74-85	glycoprotein hormone subunit alpha 2	Homo sapiens	116-123
35452678-6	2022	CD33, also called Siglec-3, is a member of the sialic acid-binding immunoglobulin-type lectin (Siglec) family of immune regulatory receptors.	N-Acetylneuraminic Acid	47-58	CD33 molecule	Homo sapiens	0-4
35507766-1	2022	Although the sialyltransferases ST3GAL1 and ST3GAL2 are known to transfer sialic acid to the galactose residue of type III disaccharides (Galbeta1,3GalNAc) in vitro, sialylation of O-linked glycosylated proteins in living cells has been largely attributed to ST3GAL1.	N-Acetylneuraminic Acid	74-85	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	32-39
35507766-1	2022	Although the sialyltransferases ST3GAL1 and ST3GAL2 are known to transfer sialic acid to the galactose residue of type III disaccharides (Galbeta1,3GalNAc) in vitro, sialylation of O-linked glycosylated proteins in living cells has been largely attributed to ST3GAL1.	N-Acetylneuraminic Acid	74-85	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Homo sapiens	44-51
35507766-1	2022	Although the sialyltransferases ST3GAL1 and ST3GAL2 are known to transfer sialic acid to the galactose residue of type III disaccharides (Galbeta1,3GalNAc) in vitro, sialylation of O-linked glycosylated proteins in living cells has been largely attributed to ST3GAL1.	N-Acetylneuraminic Acid	74-85	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	259-266
35503500-1	2022	GNE myopathy is an inherited neuromuscular disorder caused by mutations in GNE (UDP-N-acetylglucosamine 2-epimerase/N-acetyl mannosamine kinase) gene catalyzing the sialic acid biosynthesis pathway.	N-Acetylneuraminic Acid	165-176	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	75-78
35503500-1	2022	GNE myopathy is an inherited neuromuscular disorder caused by mutations in GNE (UDP-N-acetylglucosamine 2-epimerase/N-acetyl mannosamine kinase) gene catalyzing the sialic acid biosynthesis pathway.	N-Acetylneuraminic Acid	165-176	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	80-143
35273357-4	2022	Sialic acid on the host cell surface is the key molecule to which histones bridge subunit 2 of the S protein.	N-Acetylneuraminic Acid	0-11	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	99-100
34989000-5	2022	Lines of evidence suggest that B cell response to non-protein self-antigens such as nucleic acids and gangliosides, sialic acid-containing glycolipids, are suppressed by inhibitory B cell co-receptors CD72 and Siglec-G, respectively.	N-Acetylneuraminic Acid	116-127	CD72 molecule	Homo sapiens	201-205
35191576-1	2022	The interaction of the SARS CoV2 spike glycoprotein with two sialic acid-containing trisaccharides (a2,3 and a2,6 sialyl N-Acetyllactosamine) has been demonstrated by NMR.	N-Acetylneuraminic Acid	61-72	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	33-38
35191576-2	2022	The NMR-based distinction between the signals of those sialic acids in the glycans covalently attached to the spike protein and those belonging to the exogenous a2,3 and a2,6 sialyl N-Acetyllactosamine ligands has been achieved by synthesizing uniformly 13C-labelled trisaccharides at the sialic acid and galactose moieties.	N-Acetylneuraminic Acid	289-300	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	110-115
35191576-4	2022	Additional experiments with the spike protein in the presence of a specific antibody for the N-terminal domain and with the isolated receptor binding and N-terminal domains of the spike protein unambiguously show that the sialic acid binding site is located at the N-terminal domain.	N-Acetylneuraminic Acid	222-233	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	32-37
35191576-4	2022	Additional experiments with the spike protein in the presence of a specific antibody for the N-terminal domain and with the isolated receptor binding and N-terminal domains of the spike protein unambiguously show that the sialic acid binding site is located at the N-terminal domain.	N-Acetylneuraminic Acid	222-233	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	180-185
35585241-7	2022	Mechanistically, Phgdh interacts with the glycolytic enzyme phosphofructokinase, and the loss of this interaction activates the hexosamine-sialic acid pathway, which provides precursors for protein glycosylation.	N-Acetylneuraminic Acid	139-150	3-phosphoglycerate dehydrogenase	Mus musculus	17-22
35459795-1	2022	Siglec-15, a member of sialic-acid binding immunoglobulin type lectins, is normally expressed by myeloid cells and upregulated in some human cancers and represents a promising new target for immunotherapy.	N-Acetylneuraminic Acid	23-34	sialic acid binding Ig like lectin 15	Homo sapiens	0-9
35452678-6	2022	CD33, also called Siglec-3, is a member of the sialic acid-binding immunoglobulin-type lectin (Siglec) family of immune regulatory receptors.	N-Acetylneuraminic Acid	47-58	CD33 molecule	Homo sapiens	18-26
35479093-3	2022	The simple post-translational modification of NEU protein targets-removal of the highly electronegative sialic acid-affects protein folding, alters protein interactions with their ligands, and exposes or covers proteolytic sites.	N-Acetylneuraminic Acid	104-115	neuraminidase 1	Homo sapiens	46-49
35410995-12	2022	The results suggest that T-antigen with or without sialic acid is essential to the antiapoptotic effect of MUC21.	N-Acetylneuraminic Acid	51-62	mucin 21, cell surface associated	Homo sapiens	107-112
35077803-7	2022	In mechanism, SIGLEC15 interacted with PDAC-expressed sialic acid, preferentially alpha-2, 3 sialic acids, to stimulate SYK phosphorylation in TAM, which further promoted its immunoregulatory cytokines and chemokines production.	N-Acetylneuraminic Acid	54-65	sialic acid binding Ig like lectin 15	Homo sapiens	14-22
35444661-2	2022	Neu5Gc, a sialic acid expressed on cell surfaces, recruits factor H to protect cells from attack by the complement system.	N-Acetylneuraminic Acid	10-21	complement factor H	Homo sapiens	59-67
35077803-7	2022	In mechanism, SIGLEC15 interacted with PDAC-expressed sialic acid, preferentially alpha-2, 3 sialic acids, to stimulate SYK phosphorylation in TAM, which further promoted its immunoregulatory cytokines and chemokines production.	N-Acetylneuraminic Acid	54-65	glycoprotein hormone subunit alpha 2	Homo sapiens	82-89
35077803-7	2022	In mechanism, SIGLEC15 interacted with PDAC-expressed sialic acid, preferentially alpha-2, 3 sialic acids, to stimulate SYK phosphorylation in TAM, which further promoted its immunoregulatory cytokines and chemokines production.	N-Acetylneuraminic Acid	54-65	spleen associated tyrosine kinase	Homo sapiens	120-123
35258917-4	2022	A kind of easily charged long-chain amino compound was screened first for one-step sialic acid derivatization so that only alpha-2,3- and alpha-2,6-linked isomers can be quickly and efficiently separated within 10 min by MCE due to the difference in structural conformation, whose separation mechanism was further theoretically supported by molecular dynamic simulation.	N-Acetylneuraminic Acid	83-94	glycoprotein hormone subunit alpha 2	Homo sapiens	123-130
35446251-8	2022	The 162 AA residue lies within the hemagglutination domain of Viral Protein 4 (VP4) engaged in interaction with sialic acid-containing structure during attachment to the target cell.	N-Acetylneuraminic Acid	112-123	outer capsid spike protein VP4	Rotavirus A	79-82
35354039-3	2022	Enriched in this screen are several genes critical for host sialic acid biosynthesis and transportation, including the cytohesin 2 (CYTH2), tetratricopeptide repeat protein 24 (TTC24), and N-acetylneuraminate synthase (NANS), which we confirm are responsible for efficient influenza viral infection.	N-Acetylneuraminic Acid	60-71	cytohesin 2	Homo sapiens	119-130
35354039-3	2022	Enriched in this screen are several genes critical for host sialic acid biosynthesis and transportation, including the cytohesin 2 (CYTH2), tetratricopeptide repeat protein 24 (TTC24), and N-acetylneuraminate synthase (NANS), which we confirm are responsible for efficient influenza viral infection.	N-Acetylneuraminic Acid	60-71	cytohesin 2	Homo sapiens	132-137
35354039-3	2022	Enriched in this screen are several genes critical for host sialic acid biosynthesis and transportation, including the cytohesin 2 (CYTH2), tetratricopeptide repeat protein 24 (TTC24), and N-acetylneuraminate synthase (NANS), which we confirm are responsible for efficient influenza viral infection.	N-Acetylneuraminic Acid	60-71	tetratricopeptide repeat domain 24	Homo sapiens	140-175
35354039-3	2022	Enriched in this screen are several genes critical for host sialic acid biosynthesis and transportation, including the cytohesin 2 (CYTH2), tetratricopeptide repeat protein 24 (TTC24), and N-acetylneuraminate synthase (NANS), which we confirm are responsible for efficient influenza viral infection.	N-Acetylneuraminic Acid	60-71	tetratricopeptide repeat domain 24	Homo sapiens	177-182
35354039-3	2022	Enriched in this screen are several genes critical for host sialic acid biosynthesis and transportation, including the cytohesin 2 (CYTH2), tetratricopeptide repeat protein 24 (TTC24), and N-acetylneuraminate synthase (NANS), which we confirm are responsible for efficient influenza viral infection.	N-Acetylneuraminic Acid	60-71	N-acetylneuraminate synthase	Homo sapiens	189-217
35354039-3	2022	Enriched in this screen are several genes critical for host sialic acid biosynthesis and transportation, including the cytohesin 2 (CYTH2), tetratricopeptide repeat protein 24 (TTC24), and N-acetylneuraminate synthase (NANS), which we confirm are responsible for efficient influenza viral infection.	N-Acetylneuraminic Acid	60-71	N-acetylneuraminate synthase	Homo sapiens	219-223
35399671-1	2022	Background and Aims: This study aimed to detect breast milk sialic acid (SA) content and the changing pattern, to understand the various stages of breastfeeding SA secretion, and the influence factors of the human milk SA content.	N-Acetylneuraminic Acid	60-71	acyl-CoA synthetase medium chain family member 3	Homo sapiens	73-75
35179349-7	2022	Targeting of ibrutinib to TIBs was achieved by the interaction of Neu5Ac modified on inner ibrutinib-particle NLI and CD22 on the surface of TIBs.	N-Acetylneuraminic Acid	66-72	LIM domain binding 1	Homo sapiens	110-113
35179349-7	2022	Targeting of ibrutinib to TIBs was achieved by the interaction of Neu5Ac modified on inner ibrutinib-particle NLI and CD22 on the surface of TIBs.	N-Acetylneuraminic Acid	66-72	CD22 molecule	Homo sapiens	118-122
35378756-10	2022	Here we show that CD169, a macrophage- specific sialic-acid binding lectin, facilitates abortive SARS-CoV-2 infection of macrophages that results in innate immune sensing of viral replication intermediates and production of proinflammatory responses.	N-Acetylneuraminic Acid	48-59	sialic acid binding Ig like lectin 1	Homo sapiens	18-23
35408990-1	2022	The CD33 gene encodes for a member of the sialic-acid-binding immunoglobulin-type lectin (Siglec) family, and is one of the top-ranked Alzheimer"s disease (AD) risk genes identified by genome-wide association studies (GWAS).	N-Acetylneuraminic Acid	42-53	CD33 molecule	Homo sapiens	4-8
35408990-6	2022	Structural models of the CD33 variant carrying the R69G amino acid change were compared to the CD33 wild type, and used for the docking analysis using sialic acid as the ligand.	N-Acetylneuraminic Acid	151-162	CD33 molecule	Homo sapiens	25-29
35408990-6	2022	Structural models of the CD33 variant carrying the R69G amino acid change were compared to the CD33 wild type, and used for the docking analysis using sialic acid as the ligand.	N-Acetylneuraminic Acid	151-162	CD33 molecule	Homo sapiens	95-99
35408990-7	2022	Our analysis demonstrated that the CD33-R69G variant may bind sialic acid at additional binding sites compared to the wild type, thus potentially increasing its affinity/specificity for this molecule.	N-Acetylneuraminic Acid	62-73	CD33 molecule	Homo sapiens	35-39
35408990-8	2022	Our results led to a new hypothesis of rs2455069-A>G SNP as a risk factor for AD, suggesting that a long-term cumulative effect of the CD33-R69G variant results from the binding of sialic acid, acting as an enhancer of the CD33 inhibitory effects on amyloid plaque degradation.	N-Acetylneuraminic Acid	181-192	CD33 molecule	Homo sapiens	135-139
35408990-8	2022	Our results led to a new hypothesis of rs2455069-A>G SNP as a risk factor for AD, suggesting that a long-term cumulative effect of the CD33-R69G variant results from the binding of sialic acid, acting as an enhancer of the CD33 inhibitory effects on amyloid plaque degradation.	N-Acetylneuraminic Acid	181-192	CD33 molecule	Homo sapiens	223-227
35044216-5	2022	The SA-decreasing effect of ARB was demonstrated to result from its inhibitory effect on sialyltransferases (ST), ST3GAL4 and ST6GAL1 of 16-HBE cells.	N-Acetylneuraminic Acid	4-6	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	114-121
35044216-5	2022	The SA-decreasing effect of ARB was demonstrated to result from its inhibitory effect on sialyltransferases (ST), ST3GAL4 and ST6GAL1 of 16-HBE cells.	N-Acetylneuraminic Acid	4-6	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	126-133
35258917-4	2022	A kind of easily charged long-chain amino compound was screened first for one-step sialic acid derivatization so that only alpha-2,3- and alpha-2,6-linked isomers can be quickly and efficiently separated within 10 min by MCE due to the difference in structural conformation, whose separation mechanism was further theoretically supported by molecular dynamic simulation.	N-Acetylneuraminic Acid	83-94	glycoprotein hormone subunit alpha 2	Homo sapiens	138-145
35041825-3	2022	ST6GAL-1 is a sialyltransferase that adds the negatively charged sugar, sialic acid (Sia), to cell surface proteins in the Golgi, altering their function.	N-Acetylneuraminic Acid	72-83	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	0-8
35387078-3	2022	From 2010, the binding of neuraminidase (NA) to sialic acid made the traditional assay for HA inhibition antibodies (Abs) unsuitable for antigenicity characterization.	N-Acetylneuraminic Acid	48-59	neuraminidase 1	Homo sapiens	26-39
35232979-5	2022	We found that Siglec15 bound sialylated TLR2 as its receptor and that the binding of sialylated TLR2 to Siglec15 in macrophages committed to the osteoclast-lineage initiated cell fusion for osteoclast formation, in which sialic acid was transferred by the sialyltransferase ST3Gal1.	N-Acetylneuraminic Acid	221-232	toll-like receptor 2	Mus musculus	96-100
35232979-5	2022	We found that Siglec15 bound sialylated TLR2 as its receptor and that the binding of sialylated TLR2 to Siglec15 in macrophages committed to the osteoclast-lineage initiated cell fusion for osteoclast formation, in which sialic acid was transferred by the sialyltransferase ST3Gal1.	N-Acetylneuraminic Acid	221-232	sialic acid binding Ig-like lectin 15	Mus musculus	104-112
35356903-6	2022	There was weak positive correlation between prolidase and FEV1 (r = 0.222, P = .033) and FEV1/forced vital capacity (r = 0.230, P = .027).Our study shows that systemic inflammation, prolidase activity, and SA levels in stable COPD patients are associated with airflow obstruction severity.	N-Acetylneuraminic Acid	206-208	peptidase D	Homo sapiens	44-53
35392183-9	2022	The data suggest targeting of the sialic acid-Siglec axis may comprise an attractive therapeutic target particularly for the more aggressive HER2+ and triple-negative breast cancer subtypes.	N-Acetylneuraminic Acid	34-45	erb-b2 receptor tyrosine kinase 2	Homo sapiens	141-145
35238237-9	2022	The messenger RNA expression of St3gal1 that encodes an alpha-2,3 sialic acid sialyltransferase SIAT4-A showed a decrease in SLG of aged mice, confirmed by a Western blot analysis.	N-Acetylneuraminic Acid	66-77	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Mus musculus	32-39
35238237-9	2022	The messenger RNA expression of St3gal1 that encodes an alpha-2,3 sialic acid sialyltransferase SIAT4-A showed a decrease in SLG of aged mice, confirmed by a Western blot analysis.	N-Acetylneuraminic Acid	66-77	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Mus musculus	96-103
35176607-5	2022	It is shown that supplementation of Neu5Ac in the growth medium does not only induce the production of extracellular sialidases of strain CP56, but also increases the production of both alpha toxin and NetB toxin.	N-Acetylneuraminic Acid	36-42	netB	Clostridium perfringens	202-206
35151686-2	2022	Although some GPI-anchored proteins (GPI-APs), including the prion protein PrPC, have a glycan side chain composed of N-acetylgalactosamine (GalNAc)-galactose-sialic acid on the core structure of GPI glycolipid, in vivo functions of this GPI-GalNAc side chain are largely unresolved.	N-Acetylneuraminic Acid	159-170	prion protein	Mus musculus	75-79
35041991-0	2022	Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-Abeta interaction and Abeta fibrillation.	N-Acetylneuraminic Acid	70-81	apolipoprotein E	Homo sapiens	6-22
35041991-0	2022	Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-Abeta interaction and Abeta fibrillation.	N-Acetylneuraminic Acid	70-81	apolipoprotein E	Homo sapiens	92-97
35041991-0	2022	Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-Abeta interaction and Abeta fibrillation.	N-Acetylneuraminic Acid	70-81	apolipoprotein E	Homo sapiens	109-114
35041991-0	2022	Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-Abeta interaction and Abeta fibrillation.	N-Acetylneuraminic Acid	70-81	amyloid beta precursor protein	Homo sapiens	115-120
35041991-2	2022	In the present study, we found that the sialylation profiles of ApoE protein in the human brain are significantly different among the three isoforms, with ApoE2 exhibiting the most abundant sialic acid modification whereas ApoE4 had the least.	N-Acetylneuraminic Acid	190-201	apolipoprotein E	Homo sapiens	64-68
35041991-2	2022	In the present study, we found that the sialylation profiles of ApoE protein in the human brain are significantly different among the three isoforms, with ApoE2 exhibiting the most abundant sialic acid modification whereas ApoE4 had the least.	N-Acetylneuraminic Acid	190-201	apolipoprotein E	Homo sapiens	155-160
35041991-3	2022	We further observed that the sialic acid moiety in ApoE2 significantly affected the interaction between ApoE2 and Abeta peptides.	N-Acetylneuraminic Acid	29-40	apolipoprotein E	Homo sapiens	51-56
35041991-3	2022	We further observed that the sialic acid moiety in ApoE2 significantly affected the interaction between ApoE2 and Abeta peptides.	N-Acetylneuraminic Acid	29-40	apolipoprotein E	Homo sapiens	104-109
35041991-3	2022	We further observed that the sialic acid moiety in ApoE2 significantly affected the interaction between ApoE2 and Abeta peptides.	N-Acetylneuraminic Acid	29-40	amyloid beta precursor protein	Homo sapiens	114-119
35041991-4	2022	The removal of sialic acid in ApoE2 increased the ApoE2 binding affinity for the Abeta17-24 region of Abeta and promoted Abeta fibrillation.	N-Acetylneuraminic Acid	15-26	apolipoprotein E	Homo sapiens	30-35
35041991-4	2022	The removal of sialic acid in ApoE2 increased the ApoE2 binding affinity for the Abeta17-24 region of Abeta and promoted Abeta fibrillation.	N-Acetylneuraminic Acid	15-26	apolipoprotein E	Homo sapiens	50-55
35041991-4	2022	The removal of sialic acid in ApoE2 increased the ApoE2 binding affinity for the Abeta17-24 region of Abeta and promoted Abeta fibrillation.	N-Acetylneuraminic Acid	15-26	amyloid beta precursor protein	Homo sapiens	102-107
35041991-6	2022	Specifically, compared to the other two isotypes, the higher expression of sialic acid in ApoE2 may contribute to the less potent interaction between ApoE2 and Abeta and ultimately the slower rate of brain Abeta deposition, a mechanism thought to underlie ApoE2-mediated decreased risk for AD.	N-Acetylneuraminic Acid	75-86	apolipoprotein E	Homo sapiens	90-95
35041991-6	2022	Specifically, compared to the other two isotypes, the higher expression of sialic acid in ApoE2 may contribute to the less potent interaction between ApoE2 and Abeta and ultimately the slower rate of brain Abeta deposition, a mechanism thought to underlie ApoE2-mediated decreased risk for AD.	N-Acetylneuraminic Acid	75-86	apolipoprotein E	Homo sapiens	150-155
35041991-6	2022	Specifically, compared to the other two isotypes, the higher expression of sialic acid in ApoE2 may contribute to the less potent interaction between ApoE2 and Abeta and ultimately the slower rate of brain Abeta deposition, a mechanism thought to underlie ApoE2-mediated decreased risk for AD.	N-Acetylneuraminic Acid	75-86	amyloid beta precursor protein	Homo sapiens	160-165
35041991-6	2022	Specifically, compared to the other two isotypes, the higher expression of sialic acid in ApoE2 may contribute to the less potent interaction between ApoE2 and Abeta and ultimately the slower rate of brain Abeta deposition, a mechanism thought to underlie ApoE2-mediated decreased risk for AD.	N-Acetylneuraminic Acid	75-86	amyloid beta precursor protein	Homo sapiens	206-211
35041991-6	2022	Specifically, compared to the other two isotypes, the higher expression of sialic acid in ApoE2 may contribute to the less potent interaction between ApoE2 and Abeta and ultimately the slower rate of brain Abeta deposition, a mechanism thought to underlie ApoE2-mediated decreased risk for AD.	N-Acetylneuraminic Acid	75-86	apolipoprotein E	Homo sapiens	256-261
35041991-8	2022	Overall, our findings lead to the insight that the sialic acid structure is an important posttranslational modification (PTM) that alters ApoE protein functions with relevance for AD.	N-Acetylneuraminic Acid	51-62	apolipoprotein E	Homo sapiens	138-142
35199160-1	2022	OBJECTIVE: Elevated serum levels of sialic acid (SA) have been verified in patients with various inflammatory conditions.	N-Acetylneuraminic Acid	36-47	acyl-CoA synthetase medium chain family member 3	Homo sapiens	49-51
35041670-1	2022	Sialyltransferase, an enzyme responsible for attaching sialic acid to the cell surface, is reported to play a key role in cancer, making sialyltransferase a potential therapeutic target in drug development.	N-Acetylneuraminic Acid	55-66	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	0-17
35164214-1	2022	Neuraminidase (NA) is an enzyme that prevents virions from aggregating within the host cell and promotes cell-to-cell spread by cleaving glycosidic linkages to sialic acid.	N-Acetylneuraminic Acid	160-171	neuraminidase 1	Homo sapiens	0-13
35340277-2	2022	Furthermore, complementary to ACE2, both sialic acid (SA) molecules and CD147 proved relevant host receptors for SARS-CoV-2 entry, which explains the viral attack to multiple types of cells, including erythrocytes, endothelium and neural tissue.	N-Acetylneuraminic Acid	41-52	acyl-CoA synthetase medium chain family member 3	Homo sapiens	54-56
35052006-1	2022	The GNE gene encodes an enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid, a precursor of sialic acids.	N-Acetylneuraminic Acid	80-103	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	4-7
35044498-5	2022	Moreover, the sialic acid content of the EPO protein in valine-fed culture was higher than in the control culture, most likely because of the lower ammonium concentration.	N-Acetylneuraminic Acid	14-25	erythropoietin	Cricetulus griseus	41-44
35382461-3	2022	In view of the immune modulation of sialic acid (SA) on tumors, this work designs a multifunctional mesoporous silica nanoparticle (MFMSN) to divert intracellular sialylation for tumor suppression.	N-Acetylneuraminic Acid	36-47	acyl-CoA synthetase medium-chain family member 3	Mus musculus	49-51
35041670-1	2022	Sialyltransferase, an enzyme responsible for attaching sialic acid to the cell surface, is reported to play a key role in cancer, making sialyltransferase a potential therapeutic target in drug development.	N-Acetylneuraminic Acid	55-66	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	137-154
34991725-0	2022	Host tp53 mutation induces gut dysbiosis eliciting inflammation through disturbed sialic acid metabolism.	N-Acetylneuraminic Acid	82-93	tumor protein p53	Danio rerio	5-9
34991725-8	2022	CONCLUSIONS: These results demonstrate a crucial role for host tp53 in maintaining symbiosis and immune homeostasis via SA metabolism.	N-Acetylneuraminic Acid	120-122	tumor protein p53	Danio rerio	63-67
34991725-9	2022	Disturbed SA metabolism via a tp53 mutation may be exploited by specific elements of the gut microbiome, eliciting both dysbiosis and inflammation.	N-Acetylneuraminic Acid	10-12	tumor protein p53	Danio rerio	30-34
34511508-2	2022	GNE encodes UDP-GlcNAc epimerase/Mannose-6 kinase, a protein with two enzymatic activities that comprise the committed step in biosynthesis of sialic acid (SA), an essential glycan that appears on the terminal positions of many extracellular oligosaccharide chains.	N-Acetylneuraminic Acid	143-154	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	0-3
34511508-2	2022	GNE encodes UDP-GlcNAc epimerase/Mannose-6 kinase, a protein with two enzymatic activities that comprise the committed step in biosynthesis of sialic acid (SA), an essential glycan that appears on the terminal positions of many extracellular oligosaccharide chains.	N-Acetylneuraminic Acid	156-158	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	0-3
34511508-3	2022	These GNE mutations can cause a reduction of SA in many tissues, although pathology is restricted to skeletal muscles through a poorly understood mechanism.	N-Acetylneuraminic Acid	45-47	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	6-9
35106126-6	2022	The PVNP-displayed HA1 antigens react with HA-specific antibody, and retain authentic sialic acid binding specificity and hemagglutinate human erythrocytes.	N-Acetylneuraminic Acid	86-97	Rho GTPase activating protein 45	Homo sapiens	19-22
34611876-7	2022	Here we describe the use of lectin chromatography to separate prostate specific antigen (PSA) glycoforms based on their sialic acid linkage from sera of patients with prostate cancer (with PSA levels in the range of 2-20 ng/mL).	N-Acetylneuraminic Acid	120-131	kallikrein related peptidase 3	Homo sapiens	62-87
35370194-10	2022	We constructed a novel sialidase fluorescent substrate, 2-benzothiazol-2-yl-phenol derivative-based N-acetylneuraminic acid (BTP3-Neu5Ac), which detects sialidase activity in living mammalian tissues and virus-infected cells expressing viral neuraminidase.	N-Acetylneuraminic Acid	100-123	neuraminidase 1	Homo sapiens	242-255
34980816-1	2022	Follitropin Delta (Rekovellle Subcutaneous Injection 12 mug/ 36 mug/72 mug Pen) is a recombinant human follicle-stimulating hormone (rFSH) developed by Ferring Pharmaceuticals Co., Ltd. Because human follicle-stimulating hormone (FSH) gene is incorporated into a human-derived cell line (human embryonic retinoblastoma: PER.C6), the Follitropin Delta is produced with having alpha2.3 and alpha2.6 linked sialic acid sugar chain which is similar to natural human FSH.	N-Acetylneuraminic Acid	404-415	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	75-78
35355982-0	2022	Improvement of Lipoplexes With a Sialic Acid Mimetic to Target the C1858T PTPN22 Variant for Immunotherapy in Endocrine Autoimmunity.	N-Acetylneuraminic Acid	33-44	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	74-80