PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 23564882-1 2013 Microsomal epoxide hydrolase (mEH, EPHX1) is a critical xenobiotic-metabolizing enzyme, catalyzing both detoxification and bioactivation reactions that direct the disposition of chemical epoxides, including the carcinogenic metabolites of several polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 247-279 epoxide hydrolase 1 Homo sapiens 0-28 23564882-1 2013 Microsomal epoxide hydrolase (mEH, EPHX1) is a critical xenobiotic-metabolizing enzyme, catalyzing both detoxification and bioactivation reactions that direct the disposition of chemical epoxides, including the carcinogenic metabolites of several polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 247-279 epoxide hydrolase 1, microsomal Mus musculus 30-33 23564882-1 2013 Microsomal epoxide hydrolase (mEH, EPHX1) is a critical xenobiotic-metabolizing enzyme, catalyzing both detoxification and bioactivation reactions that direct the disposition of chemical epoxides, including the carcinogenic metabolites of several polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 247-279 epoxide hydrolase 1 Homo sapiens 35-40 23458896-0 2013 Mechanisms of chemokine responses by polycyclic aromatic hydrocarbons in bronchial epithelial cells: sensitization through toll-like receptor-3 priming. Polycyclic Aromatic Hydrocarbons 37-69 toll like receptor 3 Homo sapiens 123-143 23458896-4 2013 However, at a low concentration (1 muM) where neither 1-NP, 1-AP nor unsubstituted pyrene had any effect on chemokine responses, we found that all three PAHs potentiated CXCL8 and CCL5 responses induced by the TLR3 ligand polyinosinic:polycytidylic acid (Poly I:C) in BEAS-2B cells. Polycyclic Aromatic Hydrocarbons 153-157 latexin Homo sapiens 35-38 23458896-4 2013 However, at a low concentration (1 muM) where neither 1-NP, 1-AP nor unsubstituted pyrene had any effect on chemokine responses, we found that all three PAHs potentiated CXCL8 and CCL5 responses induced by the TLR3 ligand polyinosinic:polycytidylic acid (Poly I:C) in BEAS-2B cells. Polycyclic Aromatic Hydrocarbons 153-157 C-X-C motif chemokine ligand 8 Homo sapiens 170-175 23458896-4 2013 However, at a low concentration (1 muM) where neither 1-NP, 1-AP nor unsubstituted pyrene had any effect on chemokine responses, we found that all three PAHs potentiated CXCL8 and CCL5 responses induced by the TLR3 ligand polyinosinic:polycytidylic acid (Poly I:C) in BEAS-2B cells. Polycyclic Aromatic Hydrocarbons 153-157 C-C motif chemokine ligand 5 Homo sapiens 180-184 23458896-4 2013 However, at a low concentration (1 muM) where neither 1-NP, 1-AP nor unsubstituted pyrene had any effect on chemokine responses, we found that all three PAHs potentiated CXCL8 and CCL5 responses induced by the TLR3 ligand polyinosinic:polycytidylic acid (Poly I:C) in BEAS-2B cells. Polycyclic Aromatic Hydrocarbons 153-157 toll like receptor 3 Homo sapiens 210-214 23502512-4 2013 PAHs in PM can serve as ligands for the aryl hydrocarbon receptor (AhR) that induces expression of certain isozymes in the cytochrome P-450 superfamily, such as CYP1A1 and CYP1B1, localized in specific lung cell types. Polycyclic Aromatic Hydrocarbons 0-4 aryl hydrocarbon receptor Rattus norvegicus 40-65 23502512-4 2013 PAHs in PM can serve as ligands for the aryl hydrocarbon receptor (AhR) that induces expression of certain isozymes in the cytochrome P-450 superfamily, such as CYP1A1 and CYP1B1, localized in specific lung cell types. Polycyclic Aromatic Hydrocarbons 0-4 aryl hydrocarbon receptor Rattus norvegicus 67-70 23502512-4 2013 PAHs in PM can serve as ligands for the aryl hydrocarbon receptor (AhR) that induces expression of certain isozymes in the cytochrome P-450 superfamily, such as CYP1A1 and CYP1B1, localized in specific lung cell types. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 161-167 23502512-4 2013 PAHs in PM can serve as ligands for the aryl hydrocarbon receptor (AhR) that induces expression of certain isozymes in the cytochrome P-450 superfamily, such as CYP1A1 and CYP1B1, localized in specific lung cell types. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 172-178 23541289-0 2013 Source apportionment of polycyclic aromatic hydrocarbons in surface sediment of mud areas in the East China Sea using diagnostic ratios and factor analysis. Polycyclic Aromatic Hydrocarbons 24-56 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 108-111 23508959-2 2013 CYP1A1 is particularly well known for its ability to biotransform polycyclic aromatic hydrocarbons, such as benzo[a]pyrene in tobacco smoke, into carcinogens. Polycyclic Aromatic Hydrocarbons 66-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 22983614-0 2013 Polycyclic aromatic hydrocarbons in river sediments from the western and southern catchments of the Bohai Sea, China: toxicity assessment and source identification. Polycyclic Aromatic Hydrocarbons 0-32 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 106-109 23614742-3 2013 Tobacco smoke contains more than 3800 constituents, including numerous water-insoluble polycyclic aromatic hydrocarbons (PAHs) that trigger aryl hydrocarbon receptor (AhR) signalling pathways. Polycyclic Aromatic Hydrocarbons 87-119 aryl hydrocarbon receptor Homo sapiens 167-170 23614742-3 2013 Tobacco smoke contains more than 3800 constituents, including numerous water-insoluble polycyclic aromatic hydrocarbons (PAHs) that trigger aryl hydrocarbon receptor (AhR) signalling pathways. Polycyclic Aromatic Hydrocarbons 121-125 aryl hydrocarbon receptor Homo sapiens 167-170 23111888-1 2013 This study aimed to determine whether the coding (A4889G) and noncoding region (T6235C) polymorphisms of the gene coding for cytochrome P4501A1 (CYP1A1), a xenobiotic-metabolizing enzyme responsible for the metabolism of carcinogenic polycyclic aromatic hydrocarbons, are involved in the pathogenesis of ischemic stroke in Turkish population. Polycyclic Aromatic Hydrocarbons 234-266 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 125-143 23111888-1 2013 This study aimed to determine whether the coding (A4889G) and noncoding region (T6235C) polymorphisms of the gene coding for cytochrome P4501A1 (CYP1A1), a xenobiotic-metabolizing enzyme responsible for the metabolism of carcinogenic polycyclic aromatic hydrocarbons, are involved in the pathogenesis of ischemic stroke in Turkish population. Polycyclic Aromatic Hydrocarbons 234-266 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 145-151 23047765-1 2013 Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH) found in combustion processes. Polycyclic Aromatic Hydrocarbons 39-70 prohibitin 2 Mus musculus 16-19 23047765-1 2013 Benzo[a]pyrene (BaP) is a prototypical polycyclic aromatic hydrocarbon (PAH) found in combustion processes. Polycyclic Aromatic Hydrocarbons 72-75 prohibitin 2 Mus musculus 16-19 23047765-2 2013 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) and other enzymes can activate PAHs to reactive oxygenated intermediates involved in mutagenesis and tumor initiation; also, CYP1 enzymes can detoxify PAHs. Polycyclic Aromatic Hydrocarbons 84-88 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-27 23047765-2 2013 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) and other enzymes can activate PAHs to reactive oxygenated intermediates involved in mutagenesis and tumor initiation; also, CYP1 enzymes can detoxify PAHs. Polycyclic Aromatic Hydrocarbons 84-88 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 37-43 23047765-2 2013 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) and other enzymes can activate PAHs to reactive oxygenated intermediates involved in mutagenesis and tumor initiation; also, CYP1 enzymes can detoxify PAHs. Polycyclic Aromatic Hydrocarbons 84-88 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 45-51 23047765-2 2013 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) and other enzymes can activate PAHs to reactive oxygenated intermediates involved in mutagenesis and tumor initiation; also, CYP1 enzymes can detoxify PAHs. Polycyclic Aromatic Hydrocarbons 84-88 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 37-41 23047765-2 2013 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) and other enzymes can activate PAHs to reactive oxygenated intermediates involved in mutagenesis and tumor initiation; also, CYP1 enzymes can detoxify PAHs. Polycyclic Aromatic Hydrocarbons 204-208 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-27 23047765-2 2013 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) and other enzymes can activate PAHs to reactive oxygenated intermediates involved in mutagenesis and tumor initiation; also, CYP1 enzymes can detoxify PAHs. Polycyclic Aromatic Hydrocarbons 204-208 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 37-43 23047765-2 2013 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) and other enzymes can activate PAHs to reactive oxygenated intermediates involved in mutagenesis and tumor initiation; also, CYP1 enzymes can detoxify PAHs. Polycyclic Aromatic Hydrocarbons 204-208 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 45-51 23047765-2 2013 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1, CYP1B1) and other enzymes can activate PAHs to reactive oxygenated intermediates involved in mutagenesis and tumor initiation; also, CYP1 enzymes can detoxify PAHs. Polycyclic Aromatic Hydrocarbons 204-208 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 37-41 23475304-1 2013 Cytochrome P450 1A1 (CYP1A1), an important phase I xenobiotic metabolizing enzyme, is responsible for metabolizing numerous carcinogens, particularly polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 150-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 23475304-1 2013 Cytochrome P450 1A1 (CYP1A1), an important phase I xenobiotic metabolizing enzyme, is responsible for metabolizing numerous carcinogens, particularly polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 150-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 23396138-1 2013 Co-exposure to environmental polycyclic aromatic hydrocarbons (PAHs) and interleukin (IL)-1beta induces expression of the tumor-promoting cytokine IL-6 in cancer cells. Polycyclic Aromatic Hydrocarbons 29-61 interleukin 6 Homo sapiens 147-151 23396138-1 2013 Co-exposure to environmental polycyclic aromatic hydrocarbons (PAHs) and interleukin (IL)-1beta induces expression of the tumor-promoting cytokine IL-6 in cancer cells. Polycyclic Aromatic Hydrocarbons 63-67 interleukin 6 Homo sapiens 147-151 23396138-3 2013 Co-exposure to the prototypical PAH benzanthracene (BZA) and TNF-alpha was found to markedly induce mRNA expression and secretion of IL-6 in human breast cancer cells MCF-7, whereas exposure to either BZA or TNF-alpha alone was without significant effect. Polycyclic Aromatic Hydrocarbons 32-35 interleukin 6 Homo sapiens 133-137 23396138-3 2013 Co-exposure to the prototypical PAH benzanthracene (BZA) and TNF-alpha was found to markedly induce mRNA expression and secretion of IL-6 in human breast cancer cells MCF-7, whereas exposure to either BZA or TNF-alpha alone was without significant effect. Polycyclic Aromatic Hydrocarbons 32-35 tumor necrosis factor Homo sapiens 208-217 23396138-5 2013 BZA/TNF-alpha-mediated IL-6 induction in MCF-7 cells was counteracted by silencing aryl hydrocarbon receptor (AhR), known to mediates most of PAH effects. Polycyclic Aromatic Hydrocarbons 142-145 tumor necrosis factor Homo sapiens 4-13 23396138-5 2013 BZA/TNF-alpha-mediated IL-6 induction in MCF-7 cells was counteracted by silencing aryl hydrocarbon receptor (AhR), known to mediates most of PAH effects. Polycyclic Aromatic Hydrocarbons 142-145 interleukin 6 Homo sapiens 23-27 23396138-5 2013 BZA/TNF-alpha-mediated IL-6 induction in MCF-7 cells was counteracted by silencing aryl hydrocarbon receptor (AhR), known to mediates most of PAH effects. Polycyclic Aromatic Hydrocarbons 142-145 aryl hydrocarbon receptor Homo sapiens 83-108 23396138-5 2013 BZA/TNF-alpha-mediated IL-6 induction in MCF-7 cells was counteracted by silencing aryl hydrocarbon receptor (AhR), known to mediates most of PAH effects. Polycyclic Aromatic Hydrocarbons 142-145 aryl hydrocarbon receptor Homo sapiens 110-113 23396138-8 2013 This regulation of IL-6 by environmental PAHs, that is dependent of inflammatory cytokine microenvironment, may contribute to the well-known carcinogenic properties of these organic pollutants. Polycyclic Aromatic Hydrocarbons 41-45 interleukin 6 Homo sapiens 19-23 23432465-1 2013 Human cytochrome P450 (P450) 2A13 was found to interact with several polycyclic aromatic hydrocarbons (PAHs) to produce Type I binding spectra, including acenaphthene, acenaphthylene, benzo[c]phenanthrene, fluoranthene, fluoranthene-2,3-diol, and 1-nitropyrene. Polycyclic Aromatic Hydrocarbons 69-101 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 6-33 23432465-1 2013 Human cytochrome P450 (P450) 2A13 was found to interact with several polycyclic aromatic hydrocarbons (PAHs) to produce Type I binding spectra, including acenaphthene, acenaphthylene, benzo[c]phenanthrene, fluoranthene, fluoranthene-2,3-diol, and 1-nitropyrene. Polycyclic Aromatic Hydrocarbons 103-107 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 6-33 23432465-4 2013 Metabolic activation of PAHs and aryl- and heterocyclic amines to genotoxic products was examined in Salmonella typhimurium NM2009, and we found that P450 2A13 and 2A6 (as well as P450 1B1) were able to activate several of these procarcinogens. Polycyclic Aromatic Hydrocarbons 24-28 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 180-188 23432465-6 2013 These results suggest that P450 2A enzymes, as well as P450 Family 1 enzymes including P450 1B1, are major enzymes involved in activating PAHs and aryl- and heterocyclic amines, as well as tobacco-related nitrosamines. Polycyclic Aromatic Hydrocarbons 138-142 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 87-95 23564762-2 2013 PAHs and dioxins are exogenous ligands that directly bind to the aryl hydrocarbon receptor (AhR), a transcription factor that activates xenobiotic metabolism, histone modification (an important step in DNA methylation) and, ultimately, tumorigenesis. Polycyclic Aromatic Hydrocarbons 0-4 aryl hydrocarbon receptor Homo sapiens 65-90 23564762-2 2013 PAHs and dioxins are exogenous ligands that directly bind to the aryl hydrocarbon receptor (AhR), a transcription factor that activates xenobiotic metabolism, histone modification (an important step in DNA methylation) and, ultimately, tumorigenesis. Polycyclic Aromatic Hydrocarbons 0-4 aryl hydrocarbon receptor Homo sapiens 92-95 22989670-3 2013 The purpose of this study was to investigate the effects of several PAHs, as well as their monohydroxylated metabolites, on estrogen receptors (ERs), ERalpha and ERbeta. Polycyclic Aromatic Hydrocarbons 68-72 estrogen receptor 1 Homo sapiens 150-157 22989670-3 2013 The purpose of this study was to investigate the effects of several PAHs, as well as their monohydroxylated metabolites, on estrogen receptors (ERs), ERalpha and ERbeta. Polycyclic Aromatic Hydrocarbons 68-72 estrogen receptor 2 Homo sapiens 162-168 22989670-6 2013 Although the parent PAHs did not induce ERalpha or ERbeta transcriptional activity, all of the monohydroxylated PAHs (1-OH naphthanol, 9-OH phenanthrene, 1-OH pyrene) selectively induced ERbeta transcriptional activity at the concentrations tested, while not activating ERalpha. Polycyclic Aromatic Hydrocarbons 112-116 estrogen receptor 2 Homo sapiens 187-193 22989670-6 2013 Although the parent PAHs did not induce ERalpha or ERbeta transcriptional activity, all of the monohydroxylated PAHs (1-OH naphthanol, 9-OH phenanthrene, 1-OH pyrene) selectively induced ERbeta transcriptional activity at the concentrations tested, while not activating ERalpha. Polycyclic Aromatic Hydrocarbons 112-116 estrogen receptor 1 Homo sapiens 270-277 22989670-7 2013 Additionally, the monohydroxylated PAHs were able to competively bind ERbeta, induce ERbeta homodimers, and regulate ERbeta target genes. Polycyclic Aromatic Hydrocarbons 35-39 estrogen receptor 2 Homo sapiens 70-76 22989670-7 2013 Additionally, the monohydroxylated PAHs were able to competively bind ERbeta, induce ERbeta homodimers, and regulate ERbeta target genes. Polycyclic Aromatic Hydrocarbons 35-39 estrogen receptor 2 Homo sapiens 85-91 22989670-7 2013 Additionally, the monohydroxylated PAHs were able to competively bind ERbeta, induce ERbeta homodimers, and regulate ERbeta target genes. Polycyclic Aromatic Hydrocarbons 35-39 estrogen receptor 2 Homo sapiens 85-91 22989670-8 2013 Although monohydroxylated PAHs appeared to have weak agonist activity to ERbeta, our results showed that they can elicit a biologically active response from ERbeta in human breast cancer cells and potentially interfere with ERbeta signaling pathways. Polycyclic Aromatic Hydrocarbons 26-30 estrogen receptor 2 Homo sapiens 73-79 22989670-8 2013 Although monohydroxylated PAHs appeared to have weak agonist activity to ERbeta, our results showed that they can elicit a biologically active response from ERbeta in human breast cancer cells and potentially interfere with ERbeta signaling pathways. Polycyclic Aromatic Hydrocarbons 26-30 estrogen receptor 2 Homo sapiens 157-163 22989670-8 2013 Although monohydroxylated PAHs appeared to have weak agonist activity to ERbeta, our results showed that they can elicit a biologically active response from ERbeta in human breast cancer cells and potentially interfere with ERbeta signaling pathways. Polycyclic Aromatic Hydrocarbons 26-30 estrogen receptor 2 Homo sapiens 157-163 21913209-6 2013 PAH within air pollution PM(2.5) induced CYP1A1 gene expression but not CYP1A1 catalytic activity in L132 cells. Polycyclic Aromatic Hydrocarbons 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 41-47 24892667-1 2013 OBJECTIVE: Quantifying polycyclic aromatic hydrocarbon levels in urine samples taken from a population of traffic police working in the metropolitan area of Bogota who were occupationally exposed to 1-hydroxypyrene (1-OHP) and 3-hydroxy-benzo[a]pyrene (3-BaP) metabolites from polycyclic aromatic hydrocarbons (PAH) having toxicological interest, related to their detection, and a degree of exposure to particulate material having a size less than 10 micrometres (PM10) and/or other factors. Polycyclic Aromatic Hydrocarbons 23-54 prohibitin 2 Homo sapiens 255-258 23274566-0 2013 Application of a fuzzy neural network model in predicting polycyclic aromatic hydrocarbon-mediated perturbations of the Cyp1b1 transcriptional regulatory network in mouse skin. Polycyclic Aromatic Hydrocarbons 58-89 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 120-126 23274566-2 2013 Non-additive PAH interactions have been observed in regulation of cytochrome P450 (CYP) gene expression in the CYP1 family. Polycyclic Aromatic Hydrocarbons 13-16 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 66-81 23274566-2 2013 Non-additive PAH interactions have been observed in regulation of cytochrome P450 (CYP) gene expression in the CYP1 family. Polycyclic Aromatic Hydrocarbons 13-16 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 83-86 23274566-3 2013 To better understand and predict biological effects of complex mixtures, such as environmental PAHs, an 11 gene input-1 gene output fuzzy neural network (FNN) was developed for predicting PAH-mediated perturbations of dermal Cyp1b1 transcription in mice. Polycyclic Aromatic Hydrocarbons 95-98 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 225-231 22934830-8 2013 Further, responsiveness of blood CYP2A6 in human blood lymphocytes isolated from lung cancer patients has led us to suggest that associating expression profiles of CYP2A6 and other polycyclic aromatic hydrocarbons (PAH)-responsive CYPs in PBL with the genotyping data could lead to the development of a possible screen to monitor and predict environment-induced diseases and toxicity in humans. Polycyclic Aromatic Hydrocarbons 181-213 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 33-39 22934830-8 2013 Further, responsiveness of blood CYP2A6 in human blood lymphocytes isolated from lung cancer patients has led us to suggest that associating expression profiles of CYP2A6 and other polycyclic aromatic hydrocarbons (PAH)-responsive CYPs in PBL with the genotyping data could lead to the development of a possible screen to monitor and predict environment-induced diseases and toxicity in humans. Polycyclic Aromatic Hydrocarbons 215-218 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 33-39 22934830-8 2013 Further, responsiveness of blood CYP2A6 in human blood lymphocytes isolated from lung cancer patients has led us to suggest that associating expression profiles of CYP2A6 and other polycyclic aromatic hydrocarbons (PAH)-responsive CYPs in PBL with the genotyping data could lead to the development of a possible screen to monitor and predict environment-induced diseases and toxicity in humans. Polycyclic Aromatic Hydrocarbons 215-218 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 164-170 23427143-3 2013 Polycyclic aromatic hydrocarbons are well known for strong carcinogenicity and thus a severe concentration control is required for drinking water and/or river water, which is the main resource of tap water. Polycyclic Aromatic Hydrocarbons 0-32 nuclear RNA export factor 1 Homo sapiens 196-199 23127723-0 2013 Persistence of polycyclic aromatic hydrocarbons in sediments in the deeper area of the Northern Adriatic Sea (Mediterranean Sea). Polycyclic Aromatic Hydrocarbons 15-47 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 105-108 23127723-0 2013 Persistence of polycyclic aromatic hydrocarbons in sediments in the deeper area of the Northern Adriatic Sea (Mediterranean Sea). Polycyclic Aromatic Hydrocarbons 15-47 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 124-127 23127723-2 2013 In this area there are several rivers which transport polycyclic aromatic hydrocarbons (PAHs) into the sea via suspended particulate matter. Polycyclic Aromatic Hydrocarbons 54-86 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 103-106 23127723-2 2013 In this area there are several rivers which transport polycyclic aromatic hydrocarbons (PAHs) into the sea via suspended particulate matter. Polycyclic Aromatic Hydrocarbons 88-92 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 103-106 23055191-1 2013 Microsomal epoxide hydrolase 1 (EPHX1) plays an important role in both the activation and the detoxification of polycyclic aromatic hydrocarbons and aromatic amines. Polycyclic Aromatic Hydrocarbons 112-144 epoxide hydrolase 1 Homo sapiens 32-37 23092998-2 2012 The objectives of the present study were: (1) to establish the levels and spatial distribution of polycyclic aromatic hydrocarbons (PAHs) in soil across the Xiamen metropolis, (2) to evaluate the extent to which PAH concentrations were elevated in the high urbanization area (HUA) of the island and how these compared with those in the low urbanization area (LUA) of the mainland, and (3) to evaluate the PAH hazard based upon their Carcinogenic Potential (CP), defined as toxicity equivalence of PAHs. Polycyclic Aromatic Hydrocarbons 98-130 phenylalanine hydroxylase Homo sapiens 132-135 22661331-0 2013 Promoting the use of BaP as a marker for PAH exposure in UK soils. Polycyclic Aromatic Hydrocarbons 41-44 prohibitin 2 Homo sapiens 21-24 22661331-11 2013 Using all data, highly significant correlations were seen between BaP and other carcinogenic PAH with the majority of r (2) values > 0.8. Polycyclic Aromatic Hydrocarbons 93-96 prohibitin 2 Homo sapiens 66-69 22661331-13 2013 We therefore conclude that BaP is a suitable surrogate marker to represent mixtures of PAH in soil during risk assessments. Polycyclic Aromatic Hydrocarbons 87-90 prohibitin 2 Homo sapiens 27-30 23533402-3 2013 We hypothesized that different chemical entities of PAH induce Treg to become either Th2 or Th17 effector T cells through epigenetic modification of FOXP3. Polycyclic Aromatic Hydrocarbons 52-55 forkhead box P3 Homo sapiens 149-154 23128882-2 2013 It is involved in breast carcinogen activation [aromatic (AAs) and heterocyclic amines (HAs), polycyclic aromatic hydrocarbons (PAHs)], in the production of beneficial oestrogen [2-hydroxyestrone (2-OHE1)] and in converting arachidonic acid (AAc) to epoxyeicosatrienoic acids (EETs), which have anti-inflammatory properties. Polycyclic Aromatic Hydrocarbons 128-132 glycine-N-acyltransferase Homo sapiens 242-245 23147572-3 2013 Besides catalyzing the production of methylglycine (sarcosine) in one carbon metabolism pathway, GNMT was found to be able to bind a number of polycyclic aromatic hydrocarbons and inhibit DNA adducts formation. Polycyclic Aromatic Hydrocarbons 143-175 glycine N-methyltransferase Mus musculus 97-101 24266295-2 2013 The first phase of xenobiotic biotransformation in the PAH metabolism includes activities of cytochrome P450 from the CYP1 family and microsomal epoxide hydrolase. Polycyclic Aromatic Hydrocarbons 55-58 epoxide hydrolase 1 Homo sapiens 134-162 23733671-2 2013 The expression of CYP1A1 induces polycyclic aromatic hydrocarbon production in the lungs, which when over expressed, is known to cause smoking related diseases, such as cardiovascular pathologies, cancer, and diabetes. Polycyclic Aromatic Hydrocarbons 33-64 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 18-24 22955047-9 2013 This difference between PBDEs and PAHs suggests specific binding mechanisms to serum albumin even for hydrophobic compounds. Polycyclic Aromatic Hydrocarbons 34-38 albumin Homo sapiens 79-92 24601014-2 2013 We report here a study of the effect of bulk diffusivity of polycyclic aromatic hydrocarbons (PAHs) in secondary organic aerosol (SOA) on the kinetics of the heterogeneous reaction of particle-borne benzo[a]pyrene (BaP) with ozone. Polycyclic Aromatic Hydrocarbons 60-92 prohibitin 2 Homo sapiens 215-218 24601014-2 2013 We report here a study of the effect of bulk diffusivity of polycyclic aromatic hydrocarbons (PAHs) in secondary organic aerosol (SOA) on the kinetics of the heterogeneous reaction of particle-borne benzo[a]pyrene (BaP) with ozone. Polycyclic Aromatic Hydrocarbons 94-98 prohibitin 2 Homo sapiens 215-218 22805987-2 2013 Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (BaP), may have a role in this increased risk. Polycyclic Aromatic Hydrocarbons 25-57 prohibitin 2 Homo sapiens 90-93 22805987-2 2013 Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (BaP), may have a role in this increased risk. Polycyclic Aromatic Hydrocarbons 59-63 prohibitin 2 Homo sapiens 90-93 23151208-2 2013 There are numerous similarities between the patterns of cytochrome P-450 (P450) activation of DBC and its covalent binding to DNA and proteins with another polycyclic aromatic hydrocarbon (PAH), 7,12-dimethylbenz[a]anthracene (DMBA). Polycyclic Aromatic Hydrocarbons 156-187 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 56-78 23151208-2 2013 There are numerous similarities between the patterns of cytochrome P-450 (P450) activation of DBC and its covalent binding to DNA and proteins with another polycyclic aromatic hydrocarbon (PAH), 7,12-dimethylbenz[a]anthracene (DMBA). Polycyclic Aromatic Hydrocarbons 189-192 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 56-78 24454363-6 2013 Prenatal exposure to PAH was associated with reduced beta 2AR gene expression among nonsensitized mice offspring, but not increases in DNA methylation or AHR. Polycyclic Aromatic Hydrocarbons 21-24 adrenergic receptor, beta 2 Mus musculus 53-61 24454363-8 2013 In the first study that delivers PAH aerosols to mice in a relatively physiological manner, small effects on AHR and beta 2AR gene expression, but not beta 2AR agonist drug activity, were observed. Polycyclic Aromatic Hydrocarbons 33-36 adrenergic receptor, beta 2 Mus musculus 117-125 24454363-9 2013 If confirmed, the results may suggest that exposure to PAH, common ambient urban pollutants, affects beta 2AR function, although the impact on the efficacy of beta 2AR agonist drugs used in treating asthma remains uncertain. Polycyclic Aromatic Hydrocarbons 55-58 adrenergic receptor, beta 2 Mus musculus 101-109 23124928-0 2012 Friedel-Crafts arylation for the formation of C(sp2)-C(sp2) bonds: a route to unsymmetrical and functionalized polycyclic aromatic hydrocarbons from aryl triazenes. Polycyclic Aromatic Hydrocarbons 111-143 Sp2 transcription factor Homo sapiens 46-51 23124928-0 2012 Friedel-Crafts arylation for the formation of C(sp2)-C(sp2) bonds: a route to unsymmetrical and functionalized polycyclic aromatic hydrocarbons from aryl triazenes. Polycyclic Aromatic Hydrocarbons 111-143 Sp2 transcription factor Homo sapiens 53-58 23089061-6 2012 Results showed most of the 16 PAHs tested were degraded within 2-4 h. Using (14)C-labled phenanthrene and benzo(a)pyrene, we demonstrated that the wax matrix of the candle initially adsorbs the PAH, but then releases the PAH back into solution as transformed, more water soluble products. Polycyclic Aromatic Hydrocarbons 30-34 phenylalanine hydroxylase Homo sapiens 194-197 22975441-0 2012 Polycyclic aromatic hydrocarbons and dibutyl phthalate disrupt dorsal-ventral axis determination via the Wnt/beta-catenin signaling pathway in zebrafish embryos. Polycyclic Aromatic Hydrocarbons 0-32 catenin (cadherin-associated protein), beta 1 Danio rerio 109-121 22791346-3 2012 The ability of this consortium to utilise HMW PAHs such as pyrene and BaP as a sole carbon source in the presence of toxic metal Cd was demonstrated. Polycyclic Aromatic Hydrocarbons 46-50 cilia and flagella associated protein 97 Homo sapiens 42-45 22842474-5 2012 Concentrations of SigmaPAHs in CAFs ranged between 650 and 2900 mug CAF(-1), with benzo[b]fluoranthene, benzo[k]fluoranthene and indeno[123-cd]pyrene being the most abundant PAHs. Polycyclic Aromatic Hydrocarbons 23-27 chromatin assembly factor 1 subunit A Homo sapiens 68-74 22842474-6 2012 Benzo[a]pyrene (BaP) ranged between 110 and 250 mug CAF(-1), accounting regularly for 5-15% of the total carcinogenic PAHs. Polycyclic Aromatic Hydrocarbons 118-122 chromatin assembly factor 1 subunit A Homo sapiens 52-58 21452393-0 2012 Aryl hydrocarbon receptor-independent up-regulation of intracellular calcium concentration by environmental polycyclic aromatic hydrocarbons in human endothelial HMEC-1 cells. Polycyclic Aromatic Hydrocarbons 108-140 aryl hydrocarbon receptor Homo sapiens 0-25 22581694-1 2012 It is well known that the aryl hydrocarbon receptor (AhR) is involved in the toxicity of halogenated aromatic hydrocarbons (HAH) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 133-165 aryl hydrocarbon receptor Homo sapiens 26-51 22581694-1 2012 It is well known that the aryl hydrocarbon receptor (AhR) is involved in the toxicity of halogenated aromatic hydrocarbons (HAH) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 133-165 aryl hydrocarbon receptor Homo sapiens 53-56 22581694-1 2012 It is well known that the aryl hydrocarbon receptor (AhR) is involved in the toxicity of halogenated aromatic hydrocarbons (HAH) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 167-170 aryl hydrocarbon receptor Homo sapiens 26-51 22581694-1 2012 It is well known that the aryl hydrocarbon receptor (AhR) is involved in the toxicity of halogenated aromatic hydrocarbons (HAH) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 167-170 aryl hydrocarbon receptor Homo sapiens 53-56 22761424-0 2012 Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl-hydrocarbon receptor Mus musculus 161-164 22761424-0 2012 Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 ATP-binding cassette, sub-family B (MDR/TAP), member 6 Mus musculus 115-120 22761424-0 2012 Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 aryl-hydrocarbon receptor Mus musculus 134-159 22761424-0 2012 Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 aryl-hydrocarbon receptor Mus musculus 161-164 22761424-6 2012 In the present study, we demonstrate that polycyclic aromatic hydrocarbons (PAHs), the widely distributed environmental toxicants shown to induce porphyrin accumulation causing hepatic porphyria, up-regulate ABCB6 expression in both mice and humans. Polycyclic Aromatic Hydrocarbons 42-74 ATP-binding cassette, sub-family B (MDR/TAP), member 6 Mus musculus 208-213 22761424-6 2012 In the present study, we demonstrate that polycyclic aromatic hydrocarbons (PAHs), the widely distributed environmental toxicants shown to induce porphyrin accumulation causing hepatic porphyria, up-regulate ABCB6 expression in both mice and humans. Polycyclic Aromatic Hydrocarbons 76-80 ATP-binding cassette, sub-family B (MDR/TAP), member 6 Mus musculus 208-213 21876539-7 2012 CYP1A1 is known to metabolize polycyclic aromatic hydrocarbons, which are important constituents of coffee, whereas CYP1A2 is involved in the primary metabolism of caffeine. Polycyclic Aromatic Hydrocarbons 30-62 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 22213191-1 2012 CYP1A1 (cytochrome P4501A1) catalyze the conversion of polycyclic aromatic hydrocarbons into reactive metabolites, which may induce DNA damage. Polycyclic Aromatic Hydrocarbons 55-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 22213191-1 2012 CYP1A1 (cytochrome P4501A1) catalyze the conversion of polycyclic aromatic hydrocarbons into reactive metabolites, which may induce DNA damage. Polycyclic Aromatic Hydrocarbons 55-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 8-26 21452393-1 2012 Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) constitute a major family of widely-distributed environmental toxic contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 prohibitin 2 Homo sapiens 64-69 21452393-1 2012 Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) constitute a major family of widely-distributed environmental toxic contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 184-209 21452393-1 2012 Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) constitute a major family of widely-distributed environmental toxic contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 211-214 21452393-1 2012 Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) constitute a major family of widely-distributed environmental toxic contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 prohibitin 2 Homo sapiens 64-69 21452393-1 2012 Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) constitute a major family of widely-distributed environmental toxic contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 184-209 21452393-1 2012 Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) constitute a major family of widely-distributed environmental toxic contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 211-214 21452393-7 2012 Taken together, these data demonstrate that environmental PAHs trigger [Ca(2+)](i) induction in an AhR-independent manner. Polycyclic Aromatic Hydrocarbons 58-62 aryl hydrocarbon receptor Homo sapiens 99-102 22625871-4 2012 Heavy metal P-type ATPases and thioredoxin transcripts were more abundant in the phenanthrene-amended soil, and this is the first time these proteins have been associated with polycyclic aromatic hydrocarbon (PAH) stress in microorganisms. Polycyclic Aromatic Hydrocarbons 176-207 thioredoxin Homo sapiens 31-42 22625871-4 2012 Heavy metal P-type ATPases and thioredoxin transcripts were more abundant in the phenanthrene-amended soil, and this is the first time these proteins have been associated with polycyclic aromatic hydrocarbon (PAH) stress in microorganisms. Polycyclic Aromatic Hydrocarbons 209-212 thioredoxin Homo sapiens 31-42 22761424-0 2012 Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 ATP-binding cassette, sub-family B (MDR/TAP), member 6 Mus musculus 115-120 22172412-0 2012 RASSF1A hypermethylation is associated with aflatoxin B1 and polycyclic aromatic hydrocarbon exposure in hepatocellular carcinoma. Polycyclic Aromatic Hydrocarbons 61-92 Ras association domain family member 1 Homo sapiens 0-7 22761424-0 2012 Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl-hydrocarbon receptor Mus musculus 134-159 22172412-5 2012 Multivariate analysis indicated that RASSF1A hypermethylation was related to AFB1- (p=0.046) and PAH-DNA adducts (p=0.040). Polycyclic Aromatic Hydrocarbons 97-100 Ras association domain family member 1 Homo sapiens 37-44 22172412-8 2012 CONCLUSIONS: AFB1- and PAH-DNA adducts may be associated with RASSF1A hypermethylation in hepatocarcinogenesis. Polycyclic Aromatic Hydrocarbons 23-26 Ras association domain family member 1 Homo sapiens 62-69 22643241-1 2012 Aryl hydrocarbon receptor-dependent genomic effects of environmental polycyclic aromatic hydrocarbons (PAHs) have been shown to be modulated by non-genomic protein kinase C (PKC)-related pathways. Polycyclic Aromatic Hydrocarbons 69-101 aryl hydrocarbon receptor Homo sapiens 0-25 23019814-2 2012 The study permitted to identify the coke oven as the main PAH source in Genoa, causing constant exceeding of benzo(a)pyrene (BaP) air quality target (1.0 ng/m3) in the urban area till 1,900 meters distance downwind the plant. Polycyclic Aromatic Hydrocarbons 58-61 prohibitin 2 Homo sapiens 125-128 22643241-1 2012 Aryl hydrocarbon receptor-dependent genomic effects of environmental polycyclic aromatic hydrocarbons (PAHs) have been shown to be modulated by non-genomic protein kinase C (PKC)-related pathways. Polycyclic Aromatic Hydrocarbons 69-101 protein kinase C delta Homo sapiens 174-177 22643241-1 2012 Aryl hydrocarbon receptor-dependent genomic effects of environmental polycyclic aromatic hydrocarbons (PAHs) have been shown to be modulated by non-genomic protein kinase C (PKC)-related pathways. Polycyclic Aromatic Hydrocarbons 103-107 aryl hydrocarbon receptor Homo sapiens 0-25 22626472-2 2012 The purpose of this study was to investigate associations between ten monohydroxy urinary metabolites of four PAHs and three serum biomarkers of cardiovascular disease (fibrinogen, homocysteine, and white blood cell count). Polycyclic Aromatic Hydrocarbons 110-114 fibrinogen beta chain Homo sapiens 169-179 22643241-1 2012 Aryl hydrocarbon receptor-dependent genomic effects of environmental polycyclic aromatic hydrocarbons (PAHs) have been shown to be modulated by non-genomic protein kinase C (PKC)-related pathways. Polycyclic Aromatic Hydrocarbons 103-107 protein kinase C delta Homo sapiens 174-177 22643241-3 2012 Treatment by the PKC activator phorbol 12-myristate 13-acetate (PMA) was found to markedly and differentially impair the up-regulation of estrogenic markers triggered by the estrogenic PAH benzanthracene (BZA) in cultured human mammary cells; BZA-mediated mRNA up-regulation of pS2 and amphiregulin was thus increased, whereas that of progesterone receptor and CXCL12 was repressed. Polycyclic Aromatic Hydrocarbons 185-188 protein kinase C delta Homo sapiens 17-20 22626472-4 2012 The PAH metabolites of naphthalene, fluorene, phenanthrene, and pyrene each showed both positive and negative correlations with homocysteine, fibrinogen, and white blood cell count (correlation coefficient range: -0.077-0.143) in nonsmoking participants. Polycyclic Aromatic Hydrocarbons 4-7 fibrinogen beta chain Homo sapiens 142-152 22562770-4 2012 OBJECTIVES: In this study we sought to elucidate the relationship between maternal PAH exposure and promoter methylation status of IFNgamma and IL4. Polycyclic Aromatic Hydrocarbons 83-86 interferon gamma Homo sapiens 131-139 22699773-4 2012 In this study, we used our assay to examine the changes in TPO activity in response to various chemicals, including benzophenones (BPs), polycyclic aromatic hydrocarbons (PAHs), and persistent organic pollutants (POPs). Polycyclic Aromatic Hydrocarbons 137-169 thyroid peroxidase Homo sapiens 59-62 22562770-4 2012 OBJECTIVES: In this study we sought to elucidate the relationship between maternal PAH exposure and promoter methylation status of IFNgamma and IL4. Polycyclic Aromatic Hydrocarbons 83-86 interleukin 4 Homo sapiens 144-147 22562770-5 2012 METHODS: We assessed the effects of benzo[a]pyrene (BaP), a representative airborne PAH, on the methylation status of the IFNgamma and IL4 promoters in Jurkat cells and two lung adenocarcinoma cell lines, and on gene expression. Polycyclic Aromatic Hydrocarbons 84-87 interferon gamma Homo sapiens 122-130 22562770-9 2012 IFNgamma promoter methylation in cord white blood cells was associated with maternal PAH exposure in the cohort study subsample. Polycyclic Aromatic Hydrocarbons 85-88 interferon gamma Homo sapiens 0-8 22575096-5 2012 Furthermore, statistically higher levels of Sigma(18)PAH (28-224 ng/g; mean 110 ng/g) in the Yellow Sea sediment than in the SCS sediment (28-109 ng/g; mean 58 ng/g) were probably resulted from higher PAH emissions from coke industry and domestic coal combustion in North China than in South China. Polycyclic Aromatic Hydrocarbons 53-56 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 100-103 22575096-5 2012 Furthermore, statistically higher levels of Sigma(18)PAH (28-224 ng/g; mean 110 ng/g) in the Yellow Sea sediment than in the SCS sediment (28-109 ng/g; mean 58 ng/g) were probably resulted from higher PAH emissions from coke industry and domestic coal combustion in North China than in South China. Polycyclic Aromatic Hydrocarbons 201-204 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 100-103 22699773-4 2012 In this study, we used our assay to examine the changes in TPO activity in response to various chemicals, including benzophenones (BPs), polycyclic aromatic hydrocarbons (PAHs), and persistent organic pollutants (POPs). Polycyclic Aromatic Hydrocarbons 171-175 thyroid peroxidase Homo sapiens 59-62 22539616-0 2012 Contributions of aryl hydrocarbon receptor genetic variants to the risk of glioma and PAH-DNA adducts. Polycyclic Aromatic Hydrocarbons 86-89 aryl hydrocarbon receptor Homo sapiens 17-42 22539616-1 2012 The aryl hydrocarbon receptor (AHR) gene is involved in the response to polycyclic aromatic hydrocarbon (PAH) exposure. Polycyclic Aromatic Hydrocarbons 72-103 aryl hydrocarbon receptor Homo sapiens 4-29 22539616-1 2012 The aryl hydrocarbon receptor (AHR) gene is involved in the response to polycyclic aromatic hydrocarbon (PAH) exposure. Polycyclic Aromatic Hydrocarbons 72-103 aryl hydrocarbon receptor Homo sapiens 31-34 22539616-1 2012 The aryl hydrocarbon receptor (AHR) gene is involved in the response to polycyclic aromatic hydrocarbon (PAH) exposure. Polycyclic Aromatic Hydrocarbons 105-108 aryl hydrocarbon receptor Homo sapiens 4-29 22539616-1 2012 The aryl hydrocarbon receptor (AHR) gene is involved in the response to polycyclic aromatic hydrocarbon (PAH) exposure. Polycyclic Aromatic Hydrocarbons 105-108 aryl hydrocarbon receptor Homo sapiens 31-34 22539616-2 2012 To investigate the hypothesis that the genetic variants in the AHR gene might be a causal genetic susceptibility to PAH-DNA adduct formation and glioma risk, we conducted a case-control study of 384 glioma cases and 384 cancer-free controls to explore the association between six common single-nucleotide polymorphisms of the AHR gene and glioma risk. Polycyclic Aromatic Hydrocarbons 116-119 aryl hydrocarbon receptor Homo sapiens 63-66 22539616-4 2012 We further explored the contributions of the glioma risk-associated AHR polymorphisms to the levels of PAH-DNA adducts in glioma tissues based on 77 glioma patients. Polycyclic Aromatic Hydrocarbons 103-106 aryl hydrocarbon receptor Homo sapiens 68-71 22747347-0 2012 Kinetic studies of heterogeneous reactions of polycyclic aromatic hydrocarbon aerosols with NO3 radicals. Polycyclic Aromatic Hydrocarbons 46-77 NBL1, DAN family BMP antagonist Homo sapiens 92-95 22527006-7 2012 Among the targeted chemicals APs (0.66), PCBs (0.64), PAHs (0.61) and DDT (0.49) correlated well with the AChE bioassay. Polycyclic Aromatic Hydrocarbons 54-58 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 23156770-4 2012 This SERS substrate is of wide application, not only for melamine but also for nonpolar molecule such as polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 105-137 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 5-9 22466400-0 2012 Polycyclic aromatic hydrocarbons (PAHs) in the Mediterranean Sea: atmospheric occurrence, deposition and decoupling with settling fluxes in the water column. Polycyclic Aromatic Hydrocarbons 0-32 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 61-64 22466400-0 2012 Polycyclic aromatic hydrocarbons (PAHs) in the Mediterranean Sea: atmospheric occurrence, deposition and decoupling with settling fluxes in the water column. Polycyclic Aromatic Hydrocarbons 34-38 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 61-64 22466400-3 2012 The (30)PAH atmospheric deposition (dominated by low MW PAH net air-water diffusive fluxes) is estimated to be ~3100 ton y(-1) (Mediterranean) and ~500 ton y(-1) (Black Sea). Polycyclic Aromatic Hydrocarbons 9-12 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 170-173 22856136-1 2012 We have investigated the effect of polycyclic aromatic hydrocarbons (PAHs) on estrogen-metabolizing genes CYP1A1, CYP1B1, CYP19 and ERalpha and cyclin D1 genes, which control of cell division in estrogen-depended tissues. Polycyclic Aromatic Hydrocarbons 35-67 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 106-112 22446828-2 2012 In many vertebrates, CYP1A, 1B, and 1C expression is induced by agonists of the aryl hydrocarbon receptor, including toxic contaminants such as chlorinated dioxins, coplanar chlorinated biphenyls, and polynuclear aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 201-234 cytochrome P450 family 1 subfamily A member 1 S homeolog Xenopus laevis 21-30 22582767-0 2012 Importance of fundamental sp, sp2, and sp3 hydrocarbon radicals in the growth of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 81-113 Sp2 transcription factor Homo sapiens 30-33 22582767-0 2012 Importance of fundamental sp, sp2, and sp3 hydrocarbon radicals in the growth of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 81-113 Sp3 transcription factor Homo sapiens 39-42 22139300-9 2012 Since Tibetan women typically spend longer time within the tents, they were exposed to PAHs (BaP exposure = 1.81 mug/m(3)) about two times of other family members. Polycyclic Aromatic Hydrocarbons 87-91 prohibitin 2 Homo sapiens 93-96 22139300-10 2012 Among all the PAHs, Bap contributed the most (82.6%) of the total carcinogenicity. Polycyclic Aromatic Hydrocarbons 14-18 prohibitin 2 Homo sapiens 20-23 21789533-7 2012 Principle component 1 (PC1) substantially explained the dominance of PAH contamination in the MGP site soils. Polycyclic Aromatic Hydrocarbons 69-72 polycystin 1, transient receptor potential channel interacting Homo sapiens 23-26 21789533-8 2012 All PAHs, except anthracene, were positively correlated in PC1. Polycyclic Aromatic Hydrocarbons 4-8 polycystin 1, transient receptor potential channel interacting Homo sapiens 59-62 22313677-9 2012 Furthermore, the carbon black (CB) nanoparticles with different diameters could induce VCAM-1 and ICAM-1 protein expression; however, polycyclic aromatic hydrocarbons (PAHs) only increased the expression of ICAM-1 but not that of VCAM-1 in HUVECs. Polycyclic Aromatic Hydrocarbons 134-166 intercellular adhesion molecule 1 Homo sapiens 207-213 22313677-9 2012 Furthermore, the carbon black (CB) nanoparticles with different diameters could induce VCAM-1 and ICAM-1 protein expression; however, polycyclic aromatic hydrocarbons (PAHs) only increased the expression of ICAM-1 but not that of VCAM-1 in HUVECs. Polycyclic Aromatic Hydrocarbons 168-172 intercellular adhesion molecule 1 Homo sapiens 207-213 22313677-9 2012 Furthermore, the carbon black (CB) nanoparticles with different diameters could induce VCAM-1 and ICAM-1 protein expression; however, polycyclic aromatic hydrocarbons (PAHs) only increased the expression of ICAM-1 but not that of VCAM-1 in HUVECs. Polycyclic Aromatic Hydrocarbons 168-172 vascular cell adhesion molecule 1 Homo sapiens 230-236 22387805-0 2012 Polycyclic aromatic hydrocarbons suppress meiosis in primordial germ cells via the AHR signaling pathway. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor 1 alpha Gallus gallus 83-86 22387805-5 2012 Furthermore, knockdown experiments suggested that AHR was essential for the adverse effects of PAH on PGC differentiation. Polycyclic Aromatic Hydrocarbons 95-98 aryl hydrocarbon receptor 1 alpha Gallus gallus 50-53 22387805-6 2012 Collectively, these findings offer novel insight into the dynamic mechanism by which PAH affects gametogenesis, suggesting that AHR-dependent inhibition of meiosis might be the cause of reduced gamete production. Polycyclic Aromatic Hydrocarbons 85-88 aryl hydrocarbon receptor 1 alpha Gallus gallus 128-131 22856136-1 2012 We have investigated the effect of polycyclic aromatic hydrocarbons (PAHs) on estrogen-metabolizing genes CYP1A1, CYP1B1, CYP19 and ERalpha and cyclin D1 genes, which control of cell division in estrogen-depended tissues. Polycyclic Aromatic Hydrocarbons 69-73 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 114-120 22856136-1 2012 We have investigated the effect of polycyclic aromatic hydrocarbons (PAHs) on estrogen-metabolizing genes CYP1A1, CYP1B1, CYP19 and ERalpha and cyclin D1 genes, which control of cell division in estrogen-depended tissues. Polycyclic Aromatic Hydrocarbons 69-73 cytochrome P450, family 19, subfamily a, polypeptide 1 Rattus norvegicus 122-127 22856136-1 2012 We have investigated the effect of polycyclic aromatic hydrocarbons (PAHs) on estrogen-metabolizing genes CYP1A1, CYP1B1, CYP19 and ERalpha and cyclin D1 genes, which control of cell division in estrogen-depended tissues. Polycyclic Aromatic Hydrocarbons 69-73 estrogen receptor 1 Rattus norvegicus 132-139 22856136-1 2012 We have investigated the effect of polycyclic aromatic hydrocarbons (PAHs) on estrogen-metabolizing genes CYP1A1, CYP1B1, CYP19 and ERalpha and cyclin D1 genes, which control of cell division in estrogen-depended tissues. Polycyclic Aromatic Hydrocarbons 35-67 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 114-120 22856136-1 2012 We have investigated the effect of polycyclic aromatic hydrocarbons (PAHs) on estrogen-metabolizing genes CYP1A1, CYP1B1, CYP19 and ERalpha and cyclin D1 genes, which control of cell division in estrogen-depended tissues. Polycyclic Aromatic Hydrocarbons 35-67 cytochrome P450, family 19, subfamily a, polypeptide 1 Rattus norvegicus 122-127 22856136-1 2012 We have investigated the effect of polycyclic aromatic hydrocarbons (PAHs) on estrogen-metabolizing genes CYP1A1, CYP1B1, CYP19 and ERalpha and cyclin D1 genes, which control of cell division in estrogen-depended tissues. Polycyclic Aromatic Hydrocarbons 35-67 estrogen receptor 1 Rattus norvegicus 132-139 22856136-1 2012 We have investigated the effect of polycyclic aromatic hydrocarbons (PAHs) on estrogen-metabolizing genes CYP1A1, CYP1B1, CYP19 and ERalpha and cyclin D1 genes, which control of cell division in estrogen-depended tissues. Polycyclic Aromatic Hydrocarbons 69-73 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 106-112 22269188-4 2012 Herein, we explored the role of GST pi class 2 (GSTp2) in PAH- and PCB-induced cardiac toxicity in zebrafish (Danio rerio) embryos. Polycyclic Aromatic Hydrocarbons 58-61 glutathione S-transferase pi 1.1 Danio rerio 32-46 22269188-0 2012 Glutathione transferase pi class 2 (GSTp2) protects against the cardiac deformities caused by exposure to PAHs but not PCB-126 in zebrafish embryos. Polycyclic Aromatic Hydrocarbons 106-110 glutathione S-transferase pi 1.1 Danio rerio 36-41 22328298-6 2012 Declining REPs with an increasing exposure time were shown for all PAHs, indicating that this bioassay approach could be developed to assess the persistency of aryl hydrocarbon receptor (AhR) agonistic PAHs and in the risk assessment of complex PAH mixtures. Polycyclic Aromatic Hydrocarbons 67-71 aryl hydrocarbon receptor Homo sapiens 160-185 22328298-6 2012 Declining REPs with an increasing exposure time were shown for all PAHs, indicating that this bioassay approach could be developed to assess the persistency of aryl hydrocarbon receptor (AhR) agonistic PAHs and in the risk assessment of complex PAH mixtures. Polycyclic Aromatic Hydrocarbons 67-71 aryl hydrocarbon receptor Homo sapiens 187-190 22328298-6 2012 Declining REPs with an increasing exposure time were shown for all PAHs, indicating that this bioassay approach could be developed to assess the persistency of aryl hydrocarbon receptor (AhR) agonistic PAHs and in the risk assessment of complex PAH mixtures. Polycyclic Aromatic Hydrocarbons 202-206 aryl hydrocarbon receptor Homo sapiens 160-185 22328298-6 2012 Declining REPs with an increasing exposure time were shown for all PAHs, indicating that this bioassay approach could be developed to assess the persistency of aryl hydrocarbon receptor (AhR) agonistic PAHs and in the risk assessment of complex PAH mixtures. Polycyclic Aromatic Hydrocarbons 67-70 aryl hydrocarbon receptor Homo sapiens 160-185 22328298-6 2012 Declining REPs with an increasing exposure time were shown for all PAHs, indicating that this bioassay approach could be developed to assess the persistency of aryl hydrocarbon receptor (AhR) agonistic PAHs and in the risk assessment of complex PAH mixtures. Polycyclic Aromatic Hydrocarbons 67-70 aryl hydrocarbon receptor Homo sapiens 187-190 22352736-2 2012 Microsomal epoxide hydrolase (EPHX1) has an important role in the metabolism of polycyclic aromatic hydrocarbons and detoxification of procarcinogens. Polycyclic Aromatic Hydrocarbons 80-112 epoxide hydrolase 1 Homo sapiens 0-28 22352736-2 2012 Microsomal epoxide hydrolase (EPHX1) has an important role in the metabolism of polycyclic aromatic hydrocarbons and detoxification of procarcinogens. Polycyclic Aromatic Hydrocarbons 80-112 epoxide hydrolase 1 Homo sapiens 30-35 22404339-6 2012 Organic chemicals adsorbed on the three PM2.5-0.3 samples (i.e., polycyclic aromatic hydrocarbons) were able to induce the gene expression of xenobiotic-metabolizing enzymes (i.e., Cytochrome P4501A1 and 1B1, and, to a lesser extent, NADPH-quinone oxidoreductase-1). Polycyclic Aromatic Hydrocarbons 65-97 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 181-207 22429107-6 2012 The modeling results indicated that the concentration of acetylene and propargyl radicals, the main PAH precursors, as well as the PAH amounts were lower in the flame of the ethanol-benzene fuel mixture than in the pure benzene flame and that all of the formed PAHs were issued from the phenyl radical. Polycyclic Aromatic Hydrocarbons 261-265 phenylalanine hydroxylase Homo sapiens 131-134 22204937-6 2012 Higher molecular-linearity selectivity toward PAHs was obtained on Sil-poy(ODA-alt-OMI) regardless of temperature changes but at temperature below 40 C, Sil-poly(ODA) showed better planarity selectivity than that of Sil-poy(ODA-alt-OMI). Polycyclic Aromatic Hydrocarbons 46-50 STIL centriolar assembly protein Homo sapiens 67-70 22204937-6 2012 Higher molecular-linearity selectivity toward PAHs was obtained on Sil-poy(ODA-alt-OMI) regardless of temperature changes but at temperature below 40 C, Sil-poly(ODA) showed better planarity selectivity than that of Sil-poy(ODA-alt-OMI). Polycyclic Aromatic Hydrocarbons 46-50 STIL centriolar assembly protein Homo sapiens 154-157 22204937-6 2012 Higher molecular-linearity selectivity toward PAHs was obtained on Sil-poy(ODA-alt-OMI) regardless of temperature changes but at temperature below 40 C, Sil-poly(ODA) showed better planarity selectivity than that of Sil-poy(ODA-alt-OMI). Polycyclic Aromatic Hydrocarbons 46-50 STIL centriolar assembly protein Homo sapiens 154-157 22269188-4 2012 Herein, we explored the role of GST pi class 2 (GSTp2) in PAH- and PCB-induced cardiac toxicity in zebrafish (Danio rerio) embryos. Polycyclic Aromatic Hydrocarbons 58-61 glutathione S-transferase pi 1.1 Danio rerio 48-53 22374940-1 2012 The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix family of transcription factors, plays a significant role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 154-185 aryl hydrocarbon receptor Homo sapiens 4-29 22374940-1 2012 The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix family of transcription factors, plays a significant role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 154-185 aryl hydrocarbon receptor Homo sapiens 31-34 22374940-1 2012 The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix family of transcription factors, plays a significant role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 187-190 aryl hydrocarbon receptor Homo sapiens 4-29 22374940-1 2012 The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix family of transcription factors, plays a significant role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 187-190 aryl hydrocarbon receptor Homo sapiens 31-34 22374940-2 2012 In the upper aerodigestive tract of humans, tobacco smoke, a source of PAHs, activates the AhR leading to increased expression of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 71-75 aryl hydrocarbon receptor Homo sapiens 91-94 22374940-2 2012 In the upper aerodigestive tract of humans, tobacco smoke, a source of PAHs, activates the AhR leading to increased expression of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 71-75 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 130-136 22374940-2 2012 In the upper aerodigestive tract of humans, tobacco smoke, a source of PAHs, activates the AhR leading to increased expression of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 71-75 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 141-147 22374940-2 2012 In the upper aerodigestive tract of humans, tobacco smoke, a source of PAHs, activates the AhR leading to increased expression of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 184-188 aryl hydrocarbon receptor Homo sapiens 91-94 22374940-2 2012 In the upper aerodigestive tract of humans, tobacco smoke, a source of PAHs, activates the AhR leading to increased expression of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 184-188 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 130-136 22374940-2 2012 In the upper aerodigestive tract of humans, tobacco smoke, a source of PAHs, activates the AhR leading to increased expression of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 184-188 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 141-147 22374940-3 2012 Inhibitors of Hsp90 ATPase cause a rapid decrease in levels of AhR, an Hsp90 client protein, and thereby block PAH-mediated induction of CYP1A1 and CYP1B1. Polycyclic Aromatic Hydrocarbons 111-114 heat shock protein 90 alpha family class A member 1 Homo sapiens 14-19 22374940-3 2012 Inhibitors of Hsp90 ATPase cause a rapid decrease in levels of AhR, an Hsp90 client protein, and thereby block PAH-mediated induction of CYP1A1 and CYP1B1. Polycyclic Aromatic Hydrocarbons 111-114 aryl hydrocarbon receptor Homo sapiens 63-66 22374940-3 2012 Inhibitors of Hsp90 ATPase cause a rapid decrease in levels of AhR, an Hsp90 client protein, and thereby block PAH-mediated induction of CYP1A1 and CYP1B1. Polycyclic Aromatic Hydrocarbons 111-114 heat shock protein 90 alpha family class A member 1 Homo sapiens 71-76 22374940-3 2012 Inhibitors of Hsp90 ATPase cause a rapid decrease in levels of AhR, an Hsp90 client protein, and thereby block PAH-mediated induction of CYP1A1 and CYP1B1. Polycyclic Aromatic Hydrocarbons 111-114 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 137-143 22374940-3 2012 Inhibitors of Hsp90 ATPase cause a rapid decrease in levels of AhR, an Hsp90 client protein, and thereby block PAH-mediated induction of CYP1A1 and CYP1B1. Polycyclic Aromatic Hydrocarbons 111-114 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 148-154 22374940-4 2012 The main objective of this study was to determine whether Zyflamend, a polyherbal preparation, suppressed PAH-mediated induction of CYP1A1 and CYP1B1 and inhibited DNA adduct formation and mutagenesis. Polycyclic Aromatic Hydrocarbons 106-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 132-138 22374940-4 2012 The main objective of this study was to determine whether Zyflamend, a polyherbal preparation, suppressed PAH-mediated induction of CYP1A1 and CYP1B1 and inhibited DNA adduct formation and mutagenesis. Polycyclic Aromatic Hydrocarbons 106-109 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 143-149 22265775-4 2012 The obtained microdroplet of C16C4Im-NTf2 containing the extracted PAHs is then diluted with acetonitrile and injected into a high-performance liquid chromatograph (HPLC) employing UV-vis and fluorescence detection. Polycyclic Aromatic Hydrocarbons 67-71 nuclear transport factor 2 Homo sapiens 37-41 22394227-1 2012 UNLABELLED: Transformation of an aryl hydrocarbon receptor (AhR) is the initial step to express the multiple toxicity of halogenated and polycyclic aromatic hydrocarbons (HAHs and PAHs) including dioxins. Polycyclic Aromatic Hydrocarbons 137-169 aryl hydrocarbon receptor Homo sapiens 33-58 22394227-1 2012 UNLABELLED: Transformation of an aryl hydrocarbon receptor (AhR) is the initial step to express the multiple toxicity of halogenated and polycyclic aromatic hydrocarbons (HAHs and PAHs) including dioxins. Polycyclic Aromatic Hydrocarbons 137-169 aryl hydrocarbon receptor Homo sapiens 60-63 22394227-1 2012 UNLABELLED: Transformation of an aryl hydrocarbon receptor (AhR) is the initial step to express the multiple toxicity of halogenated and polycyclic aromatic hydrocarbons (HAHs and PAHs) including dioxins. Polycyclic Aromatic Hydrocarbons 180-184 aryl hydrocarbon receptor Homo sapiens 33-58 22394227-1 2012 UNLABELLED: Transformation of an aryl hydrocarbon receptor (AhR) is the initial step to express the multiple toxicity of halogenated and polycyclic aromatic hydrocarbons (HAHs and PAHs) including dioxins. Polycyclic Aromatic Hydrocarbons 180-184 aryl hydrocarbon receptor Homo sapiens 60-63 22265783-6 2012 Calibration ranges for several PAHs were from 0.02 to 200 mug L-1. Polycyclic Aromatic Hydrocarbons 31-35 immunoglobulin kappa variable 1-16 Homo sapiens 62-65 22348481-0 2012 Ah-receptor-independent stimulation of hepatoma 27 culture cell proliferation by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 81-113 aryl hydrocarbon receptor Homo sapiens 0-11 21924301-8 2012 In most cases, substitution of carbon with nitrogen and oxygen was related to increased compound degradation in comparison to unalkylated and sulphur- or unsubstituted PAH with a similar ring number.The obtained results indicate that GC2/MS can be employed for the rapid assessment of a large variety of structurally heterogeneous environmental contaminants. Polycyclic Aromatic Hydrocarbons 168-171 solute carrier family 25 member 18 Homo sapiens 234-237 22198330-3 2012 Many enzymes involved in PAH metabolism, including CYP1A1, CYP1B1, GSTM and GSTT are polymorphic, which may modulate the activation/deactivation of these compounds. Polycyclic Aromatic Hydrocarbons 25-28 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 51-57 22198330-3 2012 Many enzymes involved in PAH metabolism, including CYP1A1, CYP1B1, GSTM and GSTT are polymorphic, which may modulate the activation/deactivation of these compounds. Polycyclic Aromatic Hydrocarbons 25-28 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 59-65 22198330-3 2012 Many enzymes involved in PAH metabolism, including CYP1A1, CYP1B1, GSTM and GSTT are polymorphic, which may modulate the activation/deactivation of these compounds. Polycyclic Aromatic Hydrocarbons 25-28 glutathione S-transferase mu 2 Homo sapiens 67-71 22198330-9 2012 We observed higher 1-OHP concentrations in children with CYP1A1*2C or GSTM1*0 polymorphisms, and a positive influence of CYP1A1*2C on OTM values in children with the highest PAH exposure. Polycyclic Aromatic Hydrocarbons 174-177 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-127 22206977-12 2012 Cytosolic ALDH3 is induced by polycyclic aromatic hydrocarbons or chlorinated compounds, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin, in rat liver cells and increases during carcinogenesis. Polycyclic Aromatic Hydrocarbons 30-62 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 10-15 22120587-2 2012 Benzo[a]pyrene (BaP) is genotoxic and is a prototype of PAH carcinogens. Polycyclic Aromatic Hydrocarbons 56-59 prohibitin 2 Homo sapiens 16-19 22167199-1 2012 Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) are widely distributed environmental contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 153-178 22167199-1 2012 Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) are widely distributed environmental contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 180-183 22167199-1 2012 Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) are widely distributed environmental contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 153-178 22167199-1 2012 Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (B(a)P) are widely distributed environmental contaminants, known as potent ligands of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 180-183 22167199-2 2012 These chemicals trigger an early and transient increase of intracellular calcium concentration ([Ca(2+)](i)), required for AhR-related effects of PAHs. Polycyclic Aromatic Hydrocarbons 146-150 aryl hydrocarbon receptor Homo sapiens 123-126 22167199-9 2012 This beta2ADR-dependent signaling pathway activated by PAHs may likely be crucial for PAH-mediated up-regulation of AhR target genes, thus suggesting a contribution of beta2ADR to the health-threatening effects of these environmental pollutants. Polycyclic Aromatic Hydrocarbons 55-58 adrenoceptor beta 2 Homo sapiens 5-13 22167199-9 2012 This beta2ADR-dependent signaling pathway activated by PAHs may likely be crucial for PAH-mediated up-regulation of AhR target genes, thus suggesting a contribution of beta2ADR to the health-threatening effects of these environmental pollutants. Polycyclic Aromatic Hydrocarbons 55-58 aryl hydrocarbon receptor Homo sapiens 116-119 22167199-9 2012 This beta2ADR-dependent signaling pathway activated by PAHs may likely be crucial for PAH-mediated up-regulation of AhR target genes, thus suggesting a contribution of beta2ADR to the health-threatening effects of these environmental pollutants. Polycyclic Aromatic Hydrocarbons 55-58 adrenoceptor beta 2 Homo sapiens 168-176 22178226-1 2012 Because of the relatively high human oral exposure to polycyclic aromatic hydrocarbons (PAHs) compared to the inhalation exposure, the known carcinogenicity of this type of compounds and the limited data from oral studies available with polycyclic aromatic hydrocarbons, an oral carcinogenicity study was performed using benzo[a]pyrene (B[a]P) as a PAH representative. Polycyclic Aromatic Hydrocarbons 54-86 phenylalanine hydroxylase Homo sapiens 88-91 22348481-8 2012 Carcinogenic PAH and beta-NF activated transcription factor AP-1, and in this case activation was more pronounced in cells grown in medium with low serum content. Polycyclic Aromatic Hydrocarbons 13-16 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 60-64 22048643-7 2012 The expression of miR-638 was also examined in peripheral lymphocytes from 86 polycyclic aromatic hydrocarbons (PAHs)-exposed (PE) workers. Polycyclic Aromatic Hydrocarbons 112-116 microRNA 638 Homo sapiens 18-25 22048643-9 2012 The levels of miR-638 were correlated with the concentration of urinary 1-hydroxypyrene (1-OHP) and external levels of PAHs. Polycyclic Aromatic Hydrocarbons 119-123 microRNA 638 Homo sapiens 14-21 22028397-0 2012 CpG site-specific hypermethylation of p16INK4alpha in peripheral blood lymphocytes of PAH-exposed workers. Polycyclic Aromatic Hydrocarbons 86-89 cyclin dependent kinase inhibitor 2A Homo sapiens 38-50 22028397-4 2012 Using bisulfite sequencing, we examined the methylation status of p16(INK4alpha) promoter in peripheral blood lymphocytes (PBL) from PAH-exposed workers and in benzo(a)pyrene (BaP)-transformed human bronchial epithelial (HBE) cells. Polycyclic Aromatic Hydrocarbons 133-136 cyclin dependent kinase inhibitor 2A Homo sapiens 66-69 22028397-4 2012 Using bisulfite sequencing, we examined the methylation status of p16(INK4alpha) promoter in peripheral blood lymphocytes (PBL) from PAH-exposed workers and in benzo(a)pyrene (BaP)-transformed human bronchial epithelial (HBE) cells. Polycyclic Aromatic Hydrocarbons 133-136 cyclin dependent kinase inhibitor 2A Homo sapiens 70-79 22028397-6 2012 RESULTS: Compared with the control group, PAH-exposed workers exhibited higher levels of urinary 1-OHP (10.62 vs. 2.52 mug/L), p16(INK4alpha) methylation (7.95% vs. 1.14% for 22 "hot" CpG sites), and CBMN (7.28% vs. 2.92%) in PBLs. Polycyclic Aromatic Hydrocarbons 42-45 cyclin dependent kinase inhibitor 2A Homo sapiens 127-130 22028397-6 2012 RESULTS: Compared with the control group, PAH-exposed workers exhibited higher levels of urinary 1-OHP (10.62 vs. 2.52 mug/L), p16(INK4alpha) methylation (7.95% vs. 1.14% for 22 "hot" CpG sites), and CBMN (7.28% vs. 2.92%) in PBLs. Polycyclic Aromatic Hydrocarbons 42-45 cyclin dependent kinase inhibitor 2A Homo sapiens 131-140 22028397-7 2012 p16(INK4alpha) hypermethylation in PAH-exposed workers exhibited CpG site specificity. Polycyclic Aromatic Hydrocarbons 35-38 cyclin dependent kinase inhibitor 2A Homo sapiens 0-3 22028397-7 2012 p16(INK4alpha) hypermethylation in PAH-exposed workers exhibited CpG site specificity. Polycyclic Aromatic Hydrocarbons 35-38 cyclin dependent kinase inhibitor 2A Homo sapiens 4-13 22028397-11 2012 CONCLUSION: PAH exposure induced CpG site-specific hypermethylation of p16(INK4alpha) gene. Polycyclic Aromatic Hydrocarbons 12-15 cyclin dependent kinase inhibitor 2A Homo sapiens 71-74 22028397-11 2012 CONCLUSION: PAH exposure induced CpG site-specific hypermethylation of p16(INK4alpha) gene. Polycyclic Aromatic Hydrocarbons 12-15 cyclin dependent kinase inhibitor 2A Homo sapiens 75-84 22076448-0 2012 Polycyclic aromatic hydrocarbons activate CYP3A4 gene transcription through human pregnane X receptor. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 42-48 22466737-0 2012 On-line concentration and fluorescence determination HPLC for polycyclic aromatic hydrocarbons in seawater samples and its application to Japan Sea. Polycyclic Aromatic Hydrocarbons 62-94 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 144-147 22466737-7 2012 The proposed method was applied to the determination of PAHs in the seawater samples collected in the Japan Sea with satisfactory results and to check the present benzo[a]pyrene concentration at the beaches in Noto peninsula, Japan polluted with C-heavy oil spilled from the tanker in 1997. Polycyclic Aromatic Hydrocarbons 56-60 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 108-111 22076448-7 2012 These results suggest that PAHs contained in cigarette smoke induce CYP3A4 in human liver. Polycyclic Aromatic Hydrocarbons 27-31 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 68-74 22076448-0 2012 Polycyclic aromatic hydrocarbons activate CYP3A4 gene transcription through human pregnane X receptor. Polycyclic Aromatic Hydrocarbons 0-32 nuclear receptor subfamily 1 group I member 2 Homo sapiens 82-101 22076448-3 2012 AhR activators, polycyclic aromatic hydrocarbons (PAHs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increased CYP3A4 reporter activity and CYP3A4 mRNA expression in HepG2 cells. Polycyclic Aromatic Hydrocarbons 16-48 aryl hydrocarbon receptor Homo sapiens 0-3 22076448-3 2012 AhR activators, polycyclic aromatic hydrocarbons (PAHs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increased CYP3A4 reporter activity and CYP3A4 mRNA expression in HepG2 cells. Polycyclic Aromatic Hydrocarbons 16-48 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 113-119 22076448-3 2012 AhR activators, polycyclic aromatic hydrocarbons (PAHs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increased CYP3A4 reporter activity and CYP3A4 mRNA expression in HepG2 cells. Polycyclic Aromatic Hydrocarbons 16-48 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 142-148 22076448-3 2012 AhR activators, polycyclic aromatic hydrocarbons (PAHs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increased CYP3A4 reporter activity and CYP3A4 mRNA expression in HepG2 cells. Polycyclic Aromatic Hydrocarbons 50-54 aryl hydrocarbon receptor Homo sapiens 0-3 22076448-3 2012 AhR activators, polycyclic aromatic hydrocarbons (PAHs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increased CYP3A4 reporter activity and CYP3A4 mRNA expression in HepG2 cells. Polycyclic Aromatic Hydrocarbons 50-54 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 113-119 22076448-3 2012 AhR activators, polycyclic aromatic hydrocarbons (PAHs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increased CYP3A4 reporter activity and CYP3A4 mRNA expression in HepG2 cells. Polycyclic Aromatic Hydrocarbons 50-54 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 142-148 22076448-6 2012 The CYP3A4 reporter activity enhanced by overexpression of human PXR was further increased by treatment with PAHs and TCDD as well as by treatment with rifampicin. Polycyclic Aromatic Hydrocarbons 109-113 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 4-10 22076448-6 2012 The CYP3A4 reporter activity enhanced by overexpression of human PXR was further increased by treatment with PAHs and TCDD as well as by treatment with rifampicin. Polycyclic Aromatic Hydrocarbons 109-113 nuclear receptor subfamily 1 group I member 2 Homo sapiens 65-68 22724322-2 2012 Polycyclic aromatic hydrocarbons induce CYP1A2 enzyme, which is important in metabolism of several drugs. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 40-46 22945568-5 2012 In particular, CYP1A1 and 1B1 catalyze oxidation of PAHs toward primary epoxide species that can further be converted into multiple follow-up products, both nonenzymatically and enzymatically. Polycyclic Aromatic Hydrocarbons 52-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-29 22945568-8 2012 During the following DNA replication cycle, bulky PAH-DNA adducts may be converted into mutations, thereby affecting hot spot sites in regulatory important genes such as Ras, p53, and others. Polycyclic Aromatic Hydrocarbons 50-53 tumor protein p53 Homo sapiens 175-178 22945568-9 2012 Depending on the degree of DNA distortion and cell cycle progression, PAH-DNA adducts trigger nucleotide excision repair (NER) and various DNA damage responses that might include TP53-dependent apoptosis in certain cell types. Polycyclic Aromatic Hydrocarbons 70-73 tumor protein p53 Homo sapiens 179-183 22945568-10 2012 In fact, cellular responses to bulky PAH-DNA damage are complex because distinct signaling branches such as ATM/ATR, NER, TP53, but also MAP kinases, interact and cooperate to determine the overall outcome to cellular injuries initiated by PAH-DNA adducts. Polycyclic Aromatic Hydrocarbons 37-40 ATM serine/threonine kinase Homo sapiens 108-111 22945568-10 2012 In fact, cellular responses to bulky PAH-DNA damage are complex because distinct signaling branches such as ATM/ATR, NER, TP53, but also MAP kinases, interact and cooperate to determine the overall outcome to cellular injuries initiated by PAH-DNA adducts. Polycyclic Aromatic Hydrocarbons 37-40 ATR serine/threonine kinase Homo sapiens 112-115 22945568-10 2012 In fact, cellular responses to bulky PAH-DNA damage are complex because distinct signaling branches such as ATM/ATR, NER, TP53, but also MAP kinases, interact and cooperate to determine the overall outcome to cellular injuries initiated by PAH-DNA adducts. Polycyclic Aromatic Hydrocarbons 37-40 tumor protein p53 Homo sapiens 122-126 22945568-10 2012 In fact, cellular responses to bulky PAH-DNA damage are complex because distinct signaling branches such as ATM/ATR, NER, TP53, but also MAP kinases, interact and cooperate to determine the overall outcome to cellular injuries initiated by PAH-DNA adducts. Polycyclic Aromatic Hydrocarbons 240-243 ATM serine/threonine kinase Homo sapiens 108-111 22945568-10 2012 In fact, cellular responses to bulky PAH-DNA damage are complex because distinct signaling branches such as ATM/ATR, NER, TP53, but also MAP kinases, interact and cooperate to determine the overall outcome to cellular injuries initiated by PAH-DNA adducts. Polycyclic Aromatic Hydrocarbons 240-243 ATR serine/threonine kinase Homo sapiens 112-115 22945568-10 2012 In fact, cellular responses to bulky PAH-DNA damage are complex because distinct signaling branches such as ATM/ATR, NER, TP53, but also MAP kinases, interact and cooperate to determine the overall outcome to cellular injuries initiated by PAH-DNA adducts. Polycyclic Aromatic Hydrocarbons 240-243 tumor protein p53 Homo sapiens 122-126 21753779-2 2012 Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery. Polycyclic Aromatic Hydrocarbons 99-103 aryl hydrocarbon receptor Homo sapiens 27-30 23513693-2 2012 Knowledge of microbial community changes could aid in identification of particular microorganisms that are capable of degrading PAHs in contaminated aquifers. Polycyclic Aromatic Hydrocarbons 128-132 activation induced cytidine deaminase Homo sapiens 47-50 21753779-2 2012 Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery. Polycyclic Aromatic Hydrocarbons 65-97 aryl hydrocarbon receptor Homo sapiens 0-25 21753779-2 2012 Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery. Polycyclic Aromatic Hydrocarbons 65-97 aryl hydrocarbon receptor Homo sapiens 27-30 21753779-2 2012 Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery. Polycyclic Aromatic Hydrocarbons 65-97 NFE2 like bZIP transcription factor 2 Homo sapiens 230-273 21753779-2 2012 Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery. Polycyclic Aromatic Hydrocarbons 65-97 NFE2 like bZIP transcription factor 2 Homo sapiens 275-279 21753779-2 2012 Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery. Polycyclic Aromatic Hydrocarbons 99-103 aryl hydrocarbon receptor Homo sapiens 0-25 22150106-0 2012 Docking and QSAR comparative studies of polycyclic aromatic hydrocarbons and other procarcinogen interactions with cytochromes P450 1A1 and 1B1. Polycyclic Aromatic Hydrocarbons 40-72 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 127-143 22150106-1 2012 To obtain chemical clues on the process of bioactivation by cytochromes P450 1A1 and 1B1, some QSAR studies were carried out based on cellular experiments of the metabolic activation of polycyclic aromatic hydrocarbons and heterocyclic aromatic compounds by those enzymes. Polycyclic Aromatic Hydrocarbons 186-218 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 72-88 22225155-3 2011 Similar to pyrene, another peri-condensed polycyclic aromatic hydrocarbon we have investigated, the first two electronically excited states of BaP exhibit extensive configuration interactions. Polycyclic Aromatic Hydrocarbons 42-73 prohibitin 2 Homo sapiens 143-146 22103900-2 2012 One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 79-111 epoxide hydrolase 1 Homo sapiens 24-52 22103900-2 2012 One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 79-111 epoxide hydrolase 1 Homo sapiens 54-59 22103900-2 2012 One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 116-119 epoxide hydrolase 1 Homo sapiens 24-52 22103900-2 2012 One of these enzymes is microsomal epoxide hydrolase (EPHX1) which metabolizes polycyclic aromatic hydrocarbons, or PAH, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 116-119 epoxide hydrolase 1 Homo sapiens 54-59 21753779-2 2012 Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery. Polycyclic Aromatic Hydrocarbons 99-103 NFE2 like bZIP transcription factor 2 Homo sapiens 230-273 21753779-2 2012 Aryl hydrocarbon receptor (AhR), a receptor that is activated by polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons such as dioxin, is a sensor of the redox system against oxidative stress and regulates nuclear factor-erythroid 2-related factor-2 (Nrf2), a master switch of the redox machinery. Polycyclic Aromatic Hydrocarbons 99-103 NFE2 like bZIP transcription factor 2 Homo sapiens 275-279 21753779-10 2012 In conclusion, the engagement of AhR by KCZ exhibits the cytoprotective effect mediated by the Nrf2 redox system, which potently downregulates either cytokine-induced (AhR-independent) or PAH-induced (AhR-dependent) oxidative stress. Polycyclic Aromatic Hydrocarbons 188-191 aryl hydrocarbon receptor Homo sapiens 33-36 21753779-10 2012 In conclusion, the engagement of AhR by KCZ exhibits the cytoprotective effect mediated by the Nrf2 redox system, which potently downregulates either cytokine-induced (AhR-independent) or PAH-induced (AhR-dependent) oxidative stress. Polycyclic Aromatic Hydrocarbons 188-191 NFE2 like bZIP transcription factor 2 Homo sapiens 95-99 21376550-2 2011 In addition to NahF, NahV, and its corresponding gene nahV, were found here in multiple naphthalene-degrading bacteria isolated from industrial wastewater polluted with polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 169-201 nahF Pseudomonas putida ND6 15-19 22202470-3 2011 Because some PAHs such as Benzo[a]pyrene (BaP) are proven carcinogens and mutagens, it is necessary to continuously monitor their concentrations in the air, water, and soil. Polycyclic Aromatic Hydrocarbons 13-17 prohibitin 2 Homo sapiens 42-45 21964300-0 2011 Cardiac toxicity of 5-ring polycyclic aromatic hydrocarbons is differentially dependent on the aryl hydrocarbon receptor 2 isoform during zebrafish development. Polycyclic Aromatic Hydrocarbons 27-59 aryl hydrocarbon receptor 2 Danio rerio 95-122 22442665-1 2012 Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 139-171 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 11-39 22442665-1 2012 Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 139-171 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 41-47 22442665-1 2012 Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 173-176 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 11-39 22442665-1 2012 Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 173-176 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 41-47 22442665-4 2012 Here we report that intestinal CYP1A1 is silenced in TLR2-deficient mice, even when under exposure to the carcinogenic PAH benzo[a]pyrene (BaP). Polycyclic Aromatic Hydrocarbons 119-122 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 31-37 21617201-5 2011 We hypothesized that exposure to PAH might similarly interfere with the function of beta(2)AR in airway epithelial or smooth muscle cells, reducing the efficacy of a medication important for the treatment of asthma symptoms. Polycyclic Aromatic Hydrocarbons 33-36 adrenoceptor beta 2 Homo sapiens 84-93 21911031-1 2011 Polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BaP), are widely distributed toxic environmental contaminants well known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 prohibitin 2 Homo sapiens 65-68 21911031-1 2011 Polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BaP), are widely distributed toxic environmental contaminants well known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 192-217 21911031-1 2011 Polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BaP), are widely distributed toxic environmental contaminants well known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 219-222 21911031-1 2011 Polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BaP), are widely distributed toxic environmental contaminants well known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 prohibitin 2 Homo sapiens 65-68 21911031-1 2011 Polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BaP), are widely distributed toxic environmental contaminants well known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 192-217 21911031-1 2011 Polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BaP), are widely distributed toxic environmental contaminants well known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 219-222 21911031-5 2011 Three-methylcholanthrene, a PAH known to activate AhR like BaP, induced FcalphaRI expression, in contrast to benzo(e)pyrene, a PAH known to poorly interact with AhR. Polycyclic Aromatic Hydrocarbons 28-31 aryl hydrocarbon receptor Homo sapiens 50-53 21911031-5 2011 Three-methylcholanthrene, a PAH known to activate AhR like BaP, induced FcalphaRI expression, in contrast to benzo(e)pyrene, a PAH known to poorly interact with AhR. Polycyclic Aromatic Hydrocarbons 28-31 prohibitin 2 Homo sapiens 59-62 21617201-8 2011 Murine tracheal epithelial cells and human airway smooth muscle cells, after exposure to a PAH mixture, exhibited reduced expression and function of beta(2)AR. Polycyclic Aromatic Hydrocarbons 91-94 adrenoceptor beta 2 Homo sapiens 149-158 21617201-9 2011 These findings support our hypothesis that environmentally relevant PAHs can impede beta(2)AR-mediated airway relaxation, and suggest a new paradigm where air pollutants not only contribute to the pathogenesis of childhood asthma, but also diminish responsiveness to standard therapy. Polycyclic Aromatic Hydrocarbons 68-72 adrenoceptor beta 2 Homo sapiens 84-93 21882217-9 2011 In Latino Americans, the lung cancer risks associated with polycyclic aromatic hydrocarbon-related exposures were consistently higher in the CYP1A1 wild-type subjects as compared to the variant genotype subjects, and the interaction was statistically significant for smoking and the CYP1A1 M2 polymorphism (P-value(interaction) = 0.02). Polycyclic Aromatic Hydrocarbons 59-90 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 141-147 21882217-9 2011 In Latino Americans, the lung cancer risks associated with polycyclic aromatic hydrocarbon-related exposures were consistently higher in the CYP1A1 wild-type subjects as compared to the variant genotype subjects, and the interaction was statistically significant for smoking and the CYP1A1 M2 polymorphism (P-value(interaction) = 0.02). Polycyclic Aromatic Hydrocarbons 59-90 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 283-289 22165253-2 2011 The results showed that low-molecular weight PAHs such as naphthalene, acenaphthylene, acenaphthene and fluorene possessed the strong breakthrough capacity with the breakthrough rates close to 50% in double PUF cartridges. Polycyclic Aromatic Hydrocarbons 45-49 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 207-210 21802500-1 2011 Carcinogenic polycyclic aromatic hydrocarbons (PAHs) are known as efficient mutagens and ligands of the aryl hydrocarbon receptor (AhR), which has been suggested to play an important role in prostate carcinogenesis. Polycyclic Aromatic Hydrocarbons 13-45 aryl hydrocarbon receptor Homo sapiens 104-129 21802500-1 2011 Carcinogenic polycyclic aromatic hydrocarbons (PAHs) are known as efficient mutagens and ligands of the aryl hydrocarbon receptor (AhR), which has been suggested to play an important role in prostate carcinogenesis. Polycyclic Aromatic Hydrocarbons 13-45 aryl hydrocarbon receptor Homo sapiens 131-134 21802500-1 2011 Carcinogenic polycyclic aromatic hydrocarbons (PAHs) are known as efficient mutagens and ligands of the aryl hydrocarbon receptor (AhR), which has been suggested to play an important role in prostate carcinogenesis. Polycyclic Aromatic Hydrocarbons 47-51 aryl hydrocarbon receptor Homo sapiens 104-129 21802500-1 2011 Carcinogenic polycyclic aromatic hydrocarbons (PAHs) are known as efficient mutagens and ligands of the aryl hydrocarbon receptor (AhR), which has been suggested to play an important role in prostate carcinogenesis. Polycyclic Aromatic Hydrocarbons 47-51 aryl hydrocarbon receptor Homo sapiens 131-134 21802500-2 2011 In order to evaluate the complex relationship between the genotoxicity and the AhR-mediated activity of PAHs in prostate cells, we selected benzo[a]pyrene (BaP) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), as model genotoxic and nongenotoxic AhR ligands, respectively, to explore global changes in gene expression in LNCaP cells by microarray analysis. Polycyclic Aromatic Hydrocarbons 104-108 aryl hydrocarbon receptor Homo sapiens 79-82 21745554-8 2011 Taken together, our data demonstrated, for the first time, that a proinflammatory cytokine and an environmental PAH may interact to potentiate both DNA damage and the inflammatory response in AEII cells, which may occur through coordinated upregulation of p38 activity. Polycyclic Aromatic Hydrocarbons 112-115 mitogen activated protein kinase 14 Rattus norvegicus 256-259 21803734-2 2011 Putative colorectal procarcinogens in tobacco smoke include polycyclic aromatic hydrocarbons and heterocyclic aromatic amines that are known substrates of glutathione S-transferases (GSTs). Polycyclic Aromatic Hydrocarbons 60-92 glutathione S-transferase kappa 1 Homo sapiens 183-187 21897389-6 2011 RESULTS: The risk of RCC increased with intake of barbecued meat (P(trend)=0.04) and the PAH, benzo(a)pyrene (BaP) (multivariable-adjusted odds ratio and 95% confidence interval, highest vs lowest quartile: 1.50 (1.14, 1.95), P(trend)=0.001). Polycyclic Aromatic Hydrocarbons 89-92 prohibitin 2 Homo sapiens 110-113 21897389-9 2011 CONCLUSION: BaP intake, a PAH in barbecued meat, was positively associated with RCC. Polycyclic Aromatic Hydrocarbons 26-29 prohibitin 2 Homo sapiens 12-15 21635667-0 2011 Polycyclic aromatic hydrocarbons induce migration in human hepatocellular carcinoma cells (HepG2) through reactive oxygen species-mediated p38 MAPK signal transduction. Polycyclic Aromatic Hydrocarbons 0-32 mitogen-activated protein kinase 14 Homo sapiens 139-142 21635667-8 2011 Our results indicate that the ROS-mediated p38 MAPK signaling pathway plays an essential role in the PAH-induced migration of HepG2 cells. Polycyclic Aromatic Hydrocarbons 101-104 mitogen-activated protein kinase 14 Homo sapiens 43-46 22165027-11 2011 The method provides method detection limits in the sub to low ppb (microg/kg) range, and practical LOQs in the low ppb (microg/kg) range for most of the PAH compounds studied. Polycyclic Aromatic Hydrocarbons 153-156 TARBP2 subunit of RISC loading complex Homo sapiens 99-103 21561705-1 2011 The direct influence of ship traffic on atmospheric levels of coarse and fine particulate matter (PM(2.5), PM(10)) and fifteen polycyclic aromatic hydrocarbons (PAHs) has been estimated in the urban area of Venice. Polycyclic Aromatic Hydrocarbons 127-159 inositol polyphosphate-5-phosphatase D Homo sapiens 24-28 21561705-1 2011 The direct influence of ship traffic on atmospheric levels of coarse and fine particulate matter (PM(2.5), PM(10)) and fifteen polycyclic aromatic hydrocarbons (PAHs) has been estimated in the urban area of Venice. Polycyclic Aromatic Hydrocarbons 161-165 inositol polyphosphate-5-phosphatase D Homo sapiens 24-28 21785767-8 2011 The study of PAH distribution between the fine and coarse fraction at the urban site revealed that on average around 80% of total PAHs were associated with fine particles. Polycyclic Aromatic Hydrocarbons 130-134 phenylalanine hydroxylase Homo sapiens 13-16 21764083-2 2011 The sediment PAH concentrations of thirty-nine 2-6 ring PAHs ranged from 13.5 to 22,600 ng/g. Polycyclic Aromatic Hydrocarbons 56-60 phenylalanine hydroxylase Homo sapiens 13-16 21764083-6 2011 Molecular indices based on ratios of selected PAH concentrations were used to differentiate PAHs from pyrogenic and petrogenic and mixed origins. Polycyclic Aromatic Hydrocarbons 92-96 phenylalanine hydroxylase Homo sapiens 46-49 21669939-1 2011 Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) induces cytochrome P450 (CYP) 1A1 and 1B1 enzymes, which biotransform PAHs resulting in the formation of DNA adducts. Polycyclic Aromatic Hydrocarbons 25-57 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-106 21669939-1 2011 Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) induces cytochrome P450 (CYP) 1A1 and 1B1 enzymes, which biotransform PAHs resulting in the formation of DNA adducts. Polycyclic Aromatic Hydrocarbons 59-63 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-106 21669939-1 2011 Exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) induces cytochrome P450 (CYP) 1A1 and 1B1 enzymes, which biotransform PAHs resulting in the formation of DNA adducts. Polycyclic Aromatic Hydrocarbons 135-139 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-106 21689667-1 2011 Benzo[a]pyrene (BP) and dibenzo[a,l]pyrene (DBP) are two polycyclic aromatic hydrocarbons (PAHs) that exhibit distinctly different mutagenicity and carcinogenicity profiles. Polycyclic Aromatic Hydrocarbons 57-89 D-box binding PAR bZIP transcription factor Homo sapiens 44-47 21689667-1 2011 Benzo[a]pyrene (BP) and dibenzo[a,l]pyrene (DBP) are two polycyclic aromatic hydrocarbons (PAHs) that exhibit distinctly different mutagenicity and carcinogenicity profiles. Polycyclic Aromatic Hydrocarbons 91-95 D-box binding PAR bZIP transcription factor Homo sapiens 44-47 21762708-0 2011 Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 166-198 aryl hydrocarbon receptor Rattus norvegicus 18-43 21762708-9 2011 The AhR-mediated activity of the neutral fraction was linked to PAHs and their derivatives, as polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls were only minor contributors to the overall AhR-mediated activity. Polycyclic Aromatic Hydrocarbons 64-68 aryl hydrocarbon receptor Rattus norvegicus 4-7 21622560-3 2011 We investigated whether O-methylation by human recombinant soluble catechol-O-methyltransferase (S-COMT) is a feasible detoxication step for a panel of structurally diverse PAH-catechols produced during the redox-cycling process. Polycyclic Aromatic Hydrocarbons 173-176 catechol-O-methyltransferase Homo sapiens 67-95 21725549-1 2011 Monitoring of high-molecular weight polycyclic aromatic hydrocarbons (HMW-PAH) via simple and cost effective methods still remains a challenge. Polycyclic Aromatic Hydrocarbons 36-68 phenylalanine hydroxylase Homo sapiens 74-77 21689841-2 2011 The toxicity of PAHs and dioxins are exclusively mediated through Aryl hydrocarbon Receptor (AhR). Polycyclic Aromatic Hydrocarbons 16-20 aryl hydrocarbon receptor Homo sapiens 66-91 21689841-2 2011 The toxicity of PAHs and dioxins are exclusively mediated through Aryl hydrocarbon Receptor (AhR). Polycyclic Aromatic Hydrocarbons 16-20 aryl hydrocarbon receptor Homo sapiens 93-96 21706407-0 2011 The role of CYP1A inhibition in the embryotoxic interactions between hypoxia and polycyclic aromatic hydrocarbons (PAHs) and PAH mixtures in zebrafish (Danio rerio). Polycyclic Aromatic Hydrocarbons 81-113 cytochrome P450, family 1, subfamily A Danio rerio 12-17 21478082-6 2011 We used toxic equivalence factors to calculate benzo[a]pyrene (BaP) equivalents (BaP-eq) for individual PAHs and applied the World Health Organization unit risk (UR) for BaP (UR = 8.7 x 10-5) to estimate lifetime cancer risks due to PAH exposures. Polycyclic Aromatic Hydrocarbons 104-108 prohibitin 2 Homo sapiens 63-66 21478082-6 2011 We used toxic equivalence factors to calculate benzo[a]pyrene (BaP) equivalents (BaP-eq) for individual PAHs and applied the World Health Organization unit risk (UR) for BaP (UR = 8.7 x 10-5) to estimate lifetime cancer risks due to PAH exposures. Polycyclic Aromatic Hydrocarbons 104-107 prohibitin 2 Homo sapiens 63-66 21478082-8 2011 The contribution of gas-phase PAHs to the total BaP-eq value was between 34% and 86%. Polycyclic Aromatic Hydrocarbons 30-34 prohibitin 2 Homo sapiens 48-51 22007406-1 2011 Abstract In the present paper, a technique of laser-induced fluorescence(LIF)for direct assay of polycyclic aromatic hydrocarbons(PAH) in soil was put forward. Polycyclic Aromatic Hydrocarbons 97-129 LIF interleukin 6 family cytokine Homo sapiens 73-76 22007406-1 2011 Abstract In the present paper, a technique of laser-induced fluorescence(LIF)for direct assay of polycyclic aromatic hydrocarbons(PAH) in soil was put forward. Polycyclic Aromatic Hydrocarbons 97-129 phenylalanine hydroxylase Homo sapiens 130-133 21457773-2 2011 The activation of benzo(a)pyrene (BP), a model compound of polycyclic aromatic hydrocarbons, to its genotoxic BP-diolepoxide (BPDE) and p53 response and cell viability after BP exposure, and the p53 status in these cell lines were analyzed. Polycyclic Aromatic Hydrocarbons 59-91 tumor protein p53 Homo sapiens 195-198 21600235-0 2011 AHR2 knockdown prevents PAH-mediated cardiac toxicity and XRE- and ARE-associated gene induction in zebrafish (Danio rerio). Polycyclic Aromatic Hydrocarbons 24-27 aryl hydrocarbon receptor 2 Danio rerio 0-4 21613234-1 2011 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of a variety of environmental chemicals, such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. Polycyclic Aromatic Hydrocarbons 155-187 aryl hydrocarbon receptor Homo sapiens 4-29 21613234-1 2011 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of a variety of environmental chemicals, such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. Polycyclic Aromatic Hydrocarbons 155-187 aryl hydrocarbon receptor Homo sapiens 31-34 21613234-1 2011 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of a variety of environmental chemicals, such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. Polycyclic Aromatic Hydrocarbons 189-193 aryl hydrocarbon receptor Homo sapiens 4-29 21613234-1 2011 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the toxicity of a variety of environmental chemicals, such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. Polycyclic Aromatic Hydrocarbons 189-193 aryl hydrocarbon receptor Homo sapiens 31-34 21613234-2 2011 We hypothesized that polymorphisms of AHR may result in significant differences in sensitivity to toxic effects of PAHs or dioxins and contribute to susceptibility to male infertility. Polycyclic Aromatic Hydrocarbons 115-119 aryl hydrocarbon receptor Homo sapiens 38-41 21622560-3 2011 We investigated whether O-methylation by human recombinant soluble catechol-O-methyltransferase (S-COMT) is a feasible detoxication step for a panel of structurally diverse PAH-catechols produced during the redox-cycling process. Polycyclic Aromatic Hydrocarbons 173-176 catechol-O-methyltransferase Homo sapiens 99-103 21622560-5 2011 PAH o-quinones were reduced to the corresponding catechols by dithiothreitol under anaerobic conditions and then further O-methylated by human S-COMT in the presence of S-[3H]adenosyl-l-methionine as a methyl group donor. Polycyclic Aromatic Hydrocarbons 0-3 catechol-O-methyltransferase Homo sapiens 145-149 21622560-7 2011 Human S-COMT was able to catalyze O-methylation of all of the PAH-catechols and generated two isomeric metabolites in different proportions. Polycyclic Aromatic Hydrocarbons 62-65 catechol-O-methyltransferase Homo sapiens 8-12 21622560-11 2011 The ability of S-COMT to produce two isomeric products from PAH-catechols was rationalized using the crystal structure of the enzyme. Polycyclic Aromatic Hydrocarbons 60-63 catechol-O-methyltransferase Homo sapiens 17-21 21645723-1 2011 Benzo[a]pyrene (BaP), a member of the polycyclic aromatic hydrocarbon (PAH) class, is one of the most potent PAH carcinogens. Polycyclic Aromatic Hydrocarbons 38-69 prohibitin 2 Homo sapiens 16-19 21645723-1 2011 Benzo[a]pyrene (BaP), a member of the polycyclic aromatic hydrocarbon (PAH) class, is one of the most potent PAH carcinogens. Polycyclic Aromatic Hydrocarbons 71-74 prohibitin 2 Homo sapiens 16-19 21645723-1 2011 Benzo[a]pyrene (BaP), a member of the polycyclic aromatic hydrocarbon (PAH) class, is one of the most potent PAH carcinogens. Polycyclic Aromatic Hydrocarbons 109-112 prohibitin 2 Homo sapiens 16-19 21524783-8 2011 Two PAH source indicators, including Ant/(Ant+Phe) and Fl/(Fl+Py), indicates that PAHs sources in the RI stream sediments are most likely of petroleum origin, while PAHs in the UR and AG stream sediments most likely came from combustion activities. Polycyclic Aromatic Hydrocarbons 82-86 phenylalanine hydroxylase Homo sapiens 4-7 21484269-3 2011 Concentrations of total PAHs ranged from 4.8 to 84.4 and 0.7 to 53.8 ng/l, for source and tap water, respectively. Polycyclic Aromatic Hydrocarbons 24-28 nuclear RNA export factor 1 Homo sapiens 90-93 21515812-13 2011 These results demonstrate that the level of [D(10)]PheT in urine after oral dosing of [D(10)]phenanthrene can be used to assess individual capacity of PAH metabolism by the diol epoxide pathway. Polycyclic Aromatic Hydrocarbons 151-154 sperm associated antigen 9 Homo sapiens 51-55 21691217-0 2011 Glycine N-methyltransferase affects urinary 1-hydroxypyrene and 8-hydroxy-2"-deoxyguanosine levels after PAH exposure. Polycyclic Aromatic Hydrocarbons 105-108 glycine N-methyltransferase Homo sapiens 0-27 21691217-1 2011 OBJECTIVES: The object of this study was to assess the modulating effects of genetic polymorphisms of glycine N-methyltransferase (GNMT) genotypes on 1-hydroxypyrene (1-OHP) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) in urine from coke-oven workers, consistently exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 272-304 glycine N-methyltransferase Homo sapiens 102-129 21691217-1 2011 OBJECTIVES: The object of this study was to assess the modulating effects of genetic polymorphisms of glycine N-methyltransferase (GNMT) genotypes on 1-hydroxypyrene (1-OHP) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) in urine from coke-oven workers, consistently exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 272-304 glycine N-methyltransferase Homo sapiens 131-135 21691217-1 2011 OBJECTIVES: The object of this study was to assess the modulating effects of genetic polymorphisms of glycine N-methyltransferase (GNMT) genotypes on 1-hydroxypyrene (1-OHP) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) in urine from coke-oven workers, consistently exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 306-310 glycine N-methyltransferase Homo sapiens 102-129 21691217-1 2011 OBJECTIVES: The object of this study was to assess the modulating effects of genetic polymorphisms of glycine N-methyltransferase (GNMT) genotypes on 1-hydroxypyrene (1-OHP) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) in urine from coke-oven workers, consistently exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 306-310 glycine N-methyltransferase Homo sapiens 131-135 21691217-5 2011 CONCLUSIONS: This study suggests that GNMT STRP1 could modulate urinary 1-OHP and 8-OHdG levels in coke-oven workers exposed to PAHs. Polycyclic Aromatic Hydrocarbons 128-132 glycine N-methyltransferase Homo sapiens 38-42 21604763-3 2011 Transcription factor AhR plays a key role in the metabolic activation of PAHs to genotoxic metabolites, but the AhR activation may also contribute to the tumor promoting effects of PAHs. Polycyclic Aromatic Hydrocarbons 73-77 aryl hydrocarbon receptor Rattus norvegicus 21-24 21604763-3 2011 Transcription factor AhR plays a key role in the metabolic activation of PAHs to genotoxic metabolites, but the AhR activation may also contribute to the tumor promoting effects of PAHs. Polycyclic Aromatic Hydrocarbons 181-185 aryl hydrocarbon receptor Rattus norvegicus 21-24 21604763-3 2011 Transcription factor AhR plays a key role in the metabolic activation of PAHs to genotoxic metabolites, but the AhR activation may also contribute to the tumor promoting effects of PAHs. Polycyclic Aromatic Hydrocarbons 181-185 aryl hydrocarbon receptor Rattus norvegicus 112-115 21666091-9 2011 Polycyclic aromatic hydrocarbons found in tobacco smoke are known CYP1A2 inducers. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 66-72 21132278-0 2011 Activation of group IVC phospholipase A(2) by polycyclic aromatic hydrocarbons induces apoptosis of human coronary artery endothelial cells. Polycyclic Aromatic Hydrocarbons 46-78 phospholipase A2 group IB Homo sapiens 24-41 21132278-2 2011 The goal of this study was to determine the influence of PAHs present at a Superfund site on human coronary artery endothelial cell (HCAEC) phospholipase A(2) (PLA(2)) activity and apoptosis. Polycyclic Aromatic Hydrocarbons 57-61 phospholipase A2 group IB Homo sapiens 140-158 21132278-2 2011 The goal of this study was to determine the influence of PAHs present at a Superfund site on human coronary artery endothelial cell (HCAEC) phospholipase A(2) (PLA(2)) activity and apoptosis. Polycyclic Aromatic Hydrocarbons 57-61 phospholipase A2 group IB Homo sapiens 160-166 21252291-6 2011 Each progenitor responded equally to DMBA and BP in congenic mice expressing the PAH-resistant AhR (AhR(d)). Polycyclic Aromatic Hydrocarbons 81-84 aryl-hydrocarbon receptor Mus musculus 95-98 21419819-5 2011 Both, raw materials and final products, showed PAH profiles with light compounds representing about 99.0% of the total PAHs, mostly accounted by those having two rings (naphthalene-27.5%) or three rings (acenaphtene-16.9%; fluorene-27.1%; phenanthrene-19.5% and anthracene-3.9%). Polycyclic Aromatic Hydrocarbons 119-123 phenylalanine hydroxylase Sus scrofa 47-50 21376804-3 2011 Enzymes such as CYP1A1/1B1 and CYP2A6/2A13 activate polycyclic aromatic hydrocarbons and nitrosamines, respectively. Polycyclic Aromatic Hydrocarbons 52-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-26 21376804-3 2011 Enzymes such as CYP1A1/1B1 and CYP2A6/2A13 activate polycyclic aromatic hydrocarbons and nitrosamines, respectively. Polycyclic Aromatic Hydrocarbons 52-84 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 31-37 22096847-11 2011 CONCLUSION: The results of present study suggested that PAHs exposure could induce the shorted RTL, CYP1A1, mEH, AHR polymorphisms might influence the change of telomere length of genomic DNA in peripheral blood of workers exposed to PAHs. Polycyclic Aromatic Hydrocarbons 56-60 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 100-106 22096847-11 2011 CONCLUSION: The results of present study suggested that PAHs exposure could induce the shorted RTL, CYP1A1, mEH, AHR polymorphisms might influence the change of telomere length of genomic DNA in peripheral blood of workers exposed to PAHs. Polycyclic Aromatic Hydrocarbons 56-60 epoxide hydrolase 1, microsomal Mus musculus 108-111 22096847-11 2011 CONCLUSION: The results of present study suggested that PAHs exposure could induce the shorted RTL, CYP1A1, mEH, AHR polymorphisms might influence the change of telomere length of genomic DNA in peripheral blood of workers exposed to PAHs. Polycyclic Aromatic Hydrocarbons 56-60 aryl hydrocarbon receptor Homo sapiens 113-116 21376789-4 2011 The aim of the present work is to demonstrate the unprecedented ability of the transferrin to solubilize various polycyclic aromatic hydrocarbons in physiological solution and to explore the impact of these materials on the structure and functionality of the transferrin. Polycyclic Aromatic Hydrocarbons 113-145 transferrin Homo sapiens 79-90 21420996-2 2011 The present work, combining the use of metabolite spectra generated from metabolite standards using multiphoton spectral analysis and an "advanced unmixing process", identifies and quantifies the uptake, partitioning, and metabolite formation of one of the most important PAHs (benzo[a]pyrene, BaP) in viable cultured rat liver cells over a period of 24 h. The application of the advanced unmixing process resulted in the simultaneous identification of 8 metabolites in live cells at any single time. Polycyclic Aromatic Hydrocarbons 272-276 prohibitin 2 Rattus norvegicus 294-297 21504811-3 2011 The as-synthesized C18-MgO was employed as a solid-phase extraction sorbent for the enrichment of polycyclic aromatic hydrocarbons (PAHs) in aqueous solutions. Polycyclic Aromatic Hydrocarbons 98-130 Bardet-Biedl syndrome 9 Homo sapiens 19-22 21504811-3 2011 The as-synthesized C18-MgO was employed as a solid-phase extraction sorbent for the enrichment of polycyclic aromatic hydrocarbons (PAHs) in aqueous solutions. Polycyclic Aromatic Hydrocarbons 132-136 Bardet-Biedl syndrome 9 Homo sapiens 19-22 21342125-6 2011 Several exogenous AhR ligands, such as PAHs, polychlorinated biphenyls and halogenated dioxins, can be found in the constituents of numerous commercial products, including insulators and flame retardants, or as products of combustion processes, including chimney soot, charbroiled foods and cigarette smoke, or as the product of waste incineration. Polycyclic Aromatic Hydrocarbons 39-43 aryl hydrocarbon receptor Homo sapiens 18-21 21402622-1 2011 The cytochrome P450 1A1 (CYP1A1) is a phase I enzyme involved in many oxidative reactions that has attracted considerable attention as a candidate gene for lung cancer susceptibility based on its function as a key factor required for bioactivation of carcinogenic polycyclic aromatic hydrocarbons and catechol oestrogen formation. Polycyclic Aromatic Hydrocarbons 264-296 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-23 21402622-1 2011 The cytochrome P450 1A1 (CYP1A1) is a phase I enzyme involved in many oxidative reactions that has attracted considerable attention as a candidate gene for lung cancer susceptibility based on its function as a key factor required for bioactivation of carcinogenic polycyclic aromatic hydrocarbons and catechol oestrogen formation. Polycyclic Aromatic Hydrocarbons 264-296 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 21252291-6 2011 Each progenitor responded equally to DMBA and BP in congenic mice expressing the PAH-resistant AhR (AhR(d)). Polycyclic Aromatic Hydrocarbons 81-84 aryl-hydrocarbon receptor Mus musculus 100-106 21252291-8 2011 These PAH suppressions depend on Cyp1b1-mediated metabolism. Polycyclic Aromatic Hydrocarbons 6-9 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 33-39 21332130-5 2011 This work was aimed to demonstrate how complexation of various highly hydrophobic polycyclic aromatic hydrocarbons with representative mucin glycoprotein could lead to the formation of previously undescribed materials, which exhibit increased toxicity versus pristine polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 82-114 mucin 1, cell surface associated Bos taurus 135-140 21332130-5 2011 This work was aimed to demonstrate how complexation of various highly hydrophobic polycyclic aromatic hydrocarbons with representative mucin glycoprotein could lead to the formation of previously undescribed materials, which exhibit increased toxicity versus pristine polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 268-300 mucin 1, cell surface associated Bos taurus 135-140 21332130-7 2011 The complexes formed between the mucin and a series of polycyclic aromatic hydrocarbons were comprehensively characterized, and their toxicity was evaluated by both in vivo and in vitro assays. Polycyclic Aromatic Hydrocarbons 55-87 mucin 1, cell surface associated Bos taurus 33-38 21028851-2 2011 Benzo[a]pyrene (B[a]P), a prototypic PAH, is metabolized by cytochrome P450 (P450) 1A1/1B1 and epoxide hydrolase to (-)-B[a]P-7,8-dihydro-7,8-diol (B[a]P-7,8-dihydrodiol). Polycyclic Aromatic Hydrocarbons 37-40 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 60-90 20609135-7 2011 In adjusted models, PAH and PM(2.5) exposures in the second month of gestation were each associated with a lower prevalence of elevated cord serum IgE. Polycyclic Aromatic Hydrocarbons 20-23 immunoglobulin heavy constant epsilon Homo sapiens 147-150 20609135-9 2011 Conversely, exposures later in gestation were associated with a higher prevalence of elevated cord IgE: in the fifth month, the PR for PAH exposure was 1.64 (95% CI: 1.29, 2.08), while for PM(2.5) in the sixth month, it was 1.66 (95% CI: 1.30, 2.13). Polycyclic Aromatic Hydrocarbons 135-138 immunoglobulin heavy constant epsilon Homo sapiens 99-102 21164388-6 2011 Cell homogenates prepared from wildtype UGT2A1(75Lys308Gly) overexpressing HEK293 cells showed significant glucuronidation activity against a variety of polycyclic aromatic hydrocarbons including, 1-hydroxy-benzo(a)pyrene, benzo(a)pyrene-7,8-diol, and 5-methylchrysene-1,2-diol. Polycyclic Aromatic Hydrocarbons 153-185 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 40-46 21164388-8 2011 A significant (P<0.05) decrease (approximately 25%) in glucuronidation activity (Vmax/KM) was observed against all polycyclic aromatic hydrocarbons substrates for the UGT2A1(75Lys308Gly) variant compared with homogenates from wildtype UGT2A1(75Lys308Gly); no activity was observed for cell homogenates overexpressing the UGT2A1 variant for all substrates tested. Polycyclic Aromatic Hydrocarbons 118-150 UDP glucuronosyltransferase 2 family, polypeptide A1 Mus musculus 170-176 21164388-9 2011 CONCLUSION: These data suggest that UGT2A1 is an important detoxification enzyme in the metabolism of polycyclic aromatic hydrocarbons within target tissues for tobacco carcinogens and functional polymorphisms in UGT2A1 may play a role in tobacco-related cancer risk. Polycyclic Aromatic Hydrocarbons 102-134 UDP glucuronosyltransferase 2 family, polypeptide A1 Mus musculus 36-42 21164388-9 2011 CONCLUSION: These data suggest that UGT2A1 is an important detoxification enzyme in the metabolism of polycyclic aromatic hydrocarbons within target tissues for tobacco carcinogens and functional polymorphisms in UGT2A1 may play a role in tobacco-related cancer risk. Polycyclic Aromatic Hydrocarbons 102-134 UDP glucuronosyltransferase 2 family, polypeptide A1 Mus musculus 213-219 21426955-2 2011 This paper sets out to determine the polycyclic aromatic hydrocarbon (PAH) contamination degree of a traditionally smoked cheese: Herreno cheese, which comes from one of the Canary Islands. Polycyclic Aromatic Hydrocarbons 37-68 phenylalanine-4-hydroxylase Serinus canaria 70-73 21348526-5 2011 Nonpolar PAH fractions contributed to mutagenic and AhR-mediated activities while inhibition of GJIC and estrogenic and TTR-binding activities were exclusively observed in the polar fractions. Polycyclic Aromatic Hydrocarbons 9-12 aryl hydrocarbon receptor Homo sapiens 52-55 21348526-9 2011 Thus, not only nonpolar compounds such as PAHs, PCBs, and PCDD/Fs but also the less characterized and investigated more polar substances should be considered as potent mutagenic, estrogenic, AhR-inducing, TTR-binding, and GJIC-inhibiting components for future studies. Polycyclic Aromatic Hydrocarbons 42-46 aryl hydrocarbon receptor Homo sapiens 191-194 21348526-9 2011 Thus, not only nonpolar compounds such as PAHs, PCBs, and PCDD/Fs but also the less characterized and investigated more polar substances should be considered as potent mutagenic, estrogenic, AhR-inducing, TTR-binding, and GJIC-inhibiting components for future studies. Polycyclic Aromatic Hydrocarbons 42-46 transthyretin Homo sapiens 205-208 21216057-2 2011 A novel passive air sampler was designed and tested for measuring the vertical concentration profile of 4 low molecular weight PAHs in gaseous phase (PAH(LMW4)) in near soil surface air. Polycyclic Aromatic Hydrocarbons 127-131 phenylalanine hydroxylase Homo sapiens 150-158 24323584-5 2011 CYP1A1 is the phase I metabolizing enzyme which plays a key role in metabolic activation of polycyclic aromatic hydrocarbons which are present in cigarette smoke and considered carcinogenic. Polycyclic Aromatic Hydrocarbons 92-124 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 21162519-1 2011 A discotic polycyclic aromatic hydrocarbon, hexa-peri-hexabenzocoronene, was oriented by slow cooling from the isotropic phase on a water surface as a film. Polycyclic Aromatic Hydrocarbons 11-42 hexosaminidase subunit alpha Homo sapiens 44-48 21081473-3 2011 We conducted a case-control study of colorectal adenoma (914 cases, 1185 controls) and CRC (496 cases, 607 controls) among Japanese Americans, European Americans and Native Hawaiians to investigate the association of genetic variation in the PAH and HAA bioactivation pathway (CYP1A1, CYP1A2, CYP1B1, AHR and ARNT) identified through sequencing with risk of colorectal neoplasia, as well as their interactions with smoking and intakes of red meat and HAAs. Polycyclic Aromatic Hydrocarbons 242-245 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 277-283 21081473-3 2011 We conducted a case-control study of colorectal adenoma (914 cases, 1185 controls) and CRC (496 cases, 607 controls) among Japanese Americans, European Americans and Native Hawaiians to investigate the association of genetic variation in the PAH and HAA bioactivation pathway (CYP1A1, CYP1A2, CYP1B1, AHR and ARNT) identified through sequencing with risk of colorectal neoplasia, as well as their interactions with smoking and intakes of red meat and HAAs. Polycyclic Aromatic Hydrocarbons 242-245 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 285-291 21081473-3 2011 We conducted a case-control study of colorectal adenoma (914 cases, 1185 controls) and CRC (496 cases, 607 controls) among Japanese Americans, European Americans and Native Hawaiians to investigate the association of genetic variation in the PAH and HAA bioactivation pathway (CYP1A1, CYP1A2, CYP1B1, AHR and ARNT) identified through sequencing with risk of colorectal neoplasia, as well as their interactions with smoking and intakes of red meat and HAAs. Polycyclic Aromatic Hydrocarbons 242-245 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 293-299 21081473-3 2011 We conducted a case-control study of colorectal adenoma (914 cases, 1185 controls) and CRC (496 cases, 607 controls) among Japanese Americans, European Americans and Native Hawaiians to investigate the association of genetic variation in the PAH and HAA bioactivation pathway (CYP1A1, CYP1A2, CYP1B1, AHR and ARNT) identified through sequencing with risk of colorectal neoplasia, as well as their interactions with smoking and intakes of red meat and HAAs. Polycyclic Aromatic Hydrocarbons 242-245 aryl hydrocarbon receptor Homo sapiens 301-304 21081473-3 2011 We conducted a case-control study of colorectal adenoma (914 cases, 1185 controls) and CRC (496 cases, 607 controls) among Japanese Americans, European Americans and Native Hawaiians to investigate the association of genetic variation in the PAH and HAA bioactivation pathway (CYP1A1, CYP1A2, CYP1B1, AHR and ARNT) identified through sequencing with risk of colorectal neoplasia, as well as their interactions with smoking and intakes of red meat and HAAs. Polycyclic Aromatic Hydrocarbons 242-245 aryl hydrocarbon receptor nuclear translocator Homo sapiens 309-313 21146218-1 2011 Both the World Health Organization and the UK Expert Panel on Air Quality Standards (EPAQS) have considered benzo(a)pyrene (BaP) as a marker of the carcinogenic potency of the polycyclic aromatic hydrocarbons (PAH) mixture, when recommending their respective guidelines for PAHs in outdoor air. Polycyclic Aromatic Hydrocarbons 210-213 prohibitin 2 Homo sapiens 124-127 21146218-1 2011 Both the World Health Organization and the UK Expert Panel on Air Quality Standards (EPAQS) have considered benzo(a)pyrene (BaP) as a marker of the carcinogenic potency of the polycyclic aromatic hydrocarbons (PAH) mixture, when recommending their respective guidelines for PAHs in outdoor air. Polycyclic Aromatic Hydrocarbons 274-278 prohibitin 2 Homo sapiens 124-127 21146218-7 2011 The relative contribution of BaP to the PAH overall carcinogenic potency is similar indoors (49%), outdoors (54%) and in the smelter environment (48%) used by EPAQS to derive the UK Air Quality Standard for ambient air. Polycyclic Aromatic Hydrocarbons 40-43 prohibitin 2 Homo sapiens 29-32 21146218-8 2011 These results suggest the suitability of BaP as a marker for the carcinogenic potential of the PAH mixture irrespective of the environment. Polycyclic Aromatic Hydrocarbons 95-98 prohibitin 2 Homo sapiens 41-44 21286013-1 2011 Benzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is easily introduced to humans via consumption of grilled or smoked meat. Polycyclic Aromatic Hydrocarbons 26-57 prohibitin 2 Homo sapiens 16-19 21286013-1 2011 Benzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is easily introduced to humans via consumption of grilled or smoked meat. Polycyclic Aromatic Hydrocarbons 59-62 prohibitin 2 Homo sapiens 16-19 20881032-1 2011 The aryl hydrocarbon receptor (AHR) is activated by 3-methylcholanthrene (MC), a polycyclic aromatic hydrocarbon, and environmental contaminants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin. Polycyclic Aromatic Hydrocarbons 81-112 aryl hydrocarbon receptor Rattus norvegicus 4-29 20881032-1 2011 The aryl hydrocarbon receptor (AHR) is activated by 3-methylcholanthrene (MC), a polycyclic aromatic hydrocarbon, and environmental contaminants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin. Polycyclic Aromatic Hydrocarbons 81-112 aryl hydrocarbon receptor Rattus norvegicus 31-34 21646728-1 2011 Cytochrome P450 (CYP) 1A1 is involved in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) and is induced by several compounds, including PAHs. Polycyclic Aromatic Hydrocarbons 69-101 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-25 21646728-1 2011 Cytochrome P450 (CYP) 1A1 is involved in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) and is induced by several compounds, including PAHs. Polycyclic Aromatic Hydrocarbons 103-107 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-25 21646728-1 2011 Cytochrome P450 (CYP) 1A1 is involved in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) and is induced by several compounds, including PAHs. Polycyclic Aromatic Hydrocarbons 156-160 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-25 21787681-2 2011 CYP1A1 and GSTs enzymes are important in metabolism of PAHs. Polycyclic Aromatic Hydrocarbons 55-59 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 21787681-2 2011 CYP1A1 and GSTs enzymes are important in metabolism of PAHs. Polycyclic Aromatic Hydrocarbons 55-59 hematopoietic prostaglandin D synthase Homo sapiens 11-15 22125765-3 2011 RESULTS: good correlation (R(2)=0.8582, p<0.05) was found between Ca and Cp for PAHs with a higher gaseous state in air (AcPy, Acp, Flu, Phen, Ant, Flt, Pyr, BaA and Chry), but there was a poorer correlation (R(2)=0.1491, p=0.5123) for the PAHs with a lower gaseous state (BbF, BkF, BaP, DahA, BghiP and Ind123). Polycyclic Aromatic Hydrocarbons 83-87 solute carrier family 25 member 6 Homo sapiens 146-149 22125765-3 2011 RESULTS: good correlation (R(2)=0.8582, p<0.05) was found between Ca and Cp for PAHs with a higher gaseous state in air (AcPy, Acp, Flu, Phen, Ant, Flt, Pyr, BaA and Chry), but there was a poorer correlation (R(2)=0.1491, p=0.5123) for the PAHs with a lower gaseous state (BbF, BkF, BaP, DahA, BghiP and Ind123). Polycyclic Aromatic Hydrocarbons 83-87 fms related receptor tyrosine kinase 1 Homo sapiens 151-154 21391090-11 2011 The AhR agonists identified in Oslo harbor were mainly PAH, while in the Grenland area the compounds identified were mainly nitrogen/oxygen-containing polyaromatic compounds (N/O-PAC). Polycyclic Aromatic Hydrocarbons 55-58 aryl hydrocarbon receptor Homo sapiens 4-7 21786685-1 2011 Effect of carcinogenic polycyclic aromatic hydrocarbons (PAH) benzo(a)pyrene (BP) and 3-methylcholanthrene (MC) on transcription factor NF-kappaB activation was studied. Polycyclic Aromatic Hydrocarbons 23-55 nuclear factor kappa B subunit 1 Homo sapiens 136-145 20961953-10 2011 Coplanar PCB concentrations were generally higher in Ahr(d)-containing pup tissues; these findings are consistent with earlier studies demonstrating the crucial importance of AHR-mediated inducible CYP1 in the gastrointestinal tract as a means of detoxication of oral planar polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 275-307 pyruvate carboxylase Homo sapiens 9-12 20961953-10 2011 Coplanar PCB concentrations were generally higher in Ahr(d)-containing pup tissues; these findings are consistent with earlier studies demonstrating the crucial importance of AHR-mediated inducible CYP1 in the gastrointestinal tract as a means of detoxication of oral planar polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 275-307 aryl hydrocarbon receptor Homo sapiens 175-178 20961953-10 2011 Coplanar PCB concentrations were generally higher in Ahr(d)-containing pup tissues; these findings are consistent with earlier studies demonstrating the crucial importance of AHR-mediated inducible CYP1 in the gastrointestinal tract as a means of detoxication of oral planar polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 275-307 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 198-202 21786685-7 2011 The role of Ah receptor in PAH action on NF-kappaB activation is discussed. Polycyclic Aromatic Hydrocarbons 27-30 aryl hydrocarbon receptor Homo sapiens 12-23 21786685-7 2011 The role of Ah receptor in PAH action on NF-kappaB activation is discussed. Polycyclic Aromatic Hydrocarbons 27-30 nuclear factor kappa B subunit 1 Homo sapiens 41-50 20932893-6 2011 An historical mechanistic (Q)SAR model developed for polycyclic aromatic hydrocarbons was used to derive the new mechanistic model: descriptors were selected upfront to describe the modeled phenomenon. Polycyclic Aromatic Hydrocarbons 53-85 sarcosine dehydrogenase Homo sapiens 29-32 21461569-1 2011 Myeloperoxidase (MPO) is a phase I enzyme that can bioactivate many specific procarcinogens, including polycyclic aromatic hydrocarbons and aromatic amines. Polycyclic Aromatic Hydrocarbons 103-135 myeloperoxidase Homo sapiens 0-15 21461569-1 2011 Myeloperoxidase (MPO) is a phase I enzyme that can bioactivate many specific procarcinogens, including polycyclic aromatic hydrocarbons and aromatic amines. Polycyclic Aromatic Hydrocarbons 103-135 myeloperoxidase Homo sapiens 17-20 22066002-13 2011 FO significantly enhanced gene expression of Cyp1a1 in both the high and low dose PAH groups. Polycyclic Aromatic Hydrocarbons 82-85 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 45-51 21786685-1 2011 Effect of carcinogenic polycyclic aromatic hydrocarbons (PAH) benzo(a)pyrene (BP) and 3-methylcholanthrene (MC) on transcription factor NF-kappaB activation was studied. Polycyclic Aromatic Hydrocarbons 57-60 nuclear factor kappa B subunit 1 Homo sapiens 136-145 20883751-10 2010 A significant correlation (r=0.48, p<0.05) was obtained between the total PAHs concentration in dust extracts and the induction of RANTES mRNA. Polycyclic Aromatic Hydrocarbons 77-81 C-C motif chemokine ligand 5 Homo sapiens 134-140 21619788-7 2011 CONCLUSION: Urinary 1-OHP concentrations can be modified by GSTM1, GSTT1 and GSTP1 gene polymorphisms, indicating that these genes are involved in the metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 165-197 glutathione S-transferase mu 1 Homo sapiens 60-65 21619788-7 2011 CONCLUSION: Urinary 1-OHP concentrations can be modified by GSTM1, GSTT1 and GSTP1 gene polymorphisms, indicating that these genes are involved in the metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 165-197 glutathione S-transferase theta 1 Homo sapiens 67-72 21619788-7 2011 CONCLUSION: Urinary 1-OHP concentrations can be modified by GSTM1, GSTT1 and GSTP1 gene polymorphisms, indicating that these genes are involved in the metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 165-197 glutathione S-transferase pi 1 Homo sapiens 77-82 20957144-8 2010 Furthermore, the stratified analysis indicated that adverse effects of XRCC1 Arg194Trp, Arg399Gln polymorphisms on PAH-DNA adducts were detected only in the high PAHs exposure group. Polycyclic Aromatic Hydrocarbons 115-118 X-ray repair cross complementing 1 Homo sapiens 71-76 20935161-1 2010 The aryl hydrocarbon receptor (AHR) plays a central role in the toxic responses to halogenated dibenzo-p-dioxins ("dioxins"), in the metabolic adaptation to polycyclic aromatic hydrocarbons, and in the development of the mature vascular system. Polycyclic Aromatic Hydrocarbons 157-189 aryl-hydrocarbon receptor Mus musculus 4-29 20935161-1 2010 The aryl hydrocarbon receptor (AHR) plays a central role in the toxic responses to halogenated dibenzo-p-dioxins ("dioxins"), in the metabolic adaptation to polycyclic aromatic hydrocarbons, and in the development of the mature vascular system. Polycyclic Aromatic Hydrocarbons 157-189 aryl-hydrocarbon receptor Mus musculus 31-34 20832459-7 2010 Concomitantly the genotoxicity of these PAHs was investigated in different cell lines, using a new genotoxic assay (H2AX) in 96-well plates. Polycyclic Aromatic Hydrocarbons 40-44 H2A.X variant histone Homo sapiens 116-120 20973527-0 2010 Ozone oxidation of surface-adsorbed polycyclic aromatic hydrocarbons: role of PAH-surface interaction. Polycyclic Aromatic Hydrocarbons 36-68 phenylalanine hydroxylase Homo sapiens 78-81 20732958-10 2010 In conclusion, the results suggest that CYP1A2 plays a pivotal role in the regulation of hepatic and pulmonary CYP1A1 by PAHs, a phenomenon that potentially has important implications for PAH-mediated carcinogenesis. Polycyclic Aromatic Hydrocarbons 121-125 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 40-46 20732958-10 2010 In conclusion, the results suggest that CYP1A2 plays a pivotal role in the regulation of hepatic and pulmonary CYP1A1 by PAHs, a phenomenon that potentially has important implications for PAH-mediated carcinogenesis. Polycyclic Aromatic Hydrocarbons 121-125 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 111-117 20732958-10 2010 In conclusion, the results suggest that CYP1A2 plays a pivotal role in the regulation of hepatic and pulmonary CYP1A1 by PAHs, a phenomenon that potentially has important implications for PAH-mediated carcinogenesis. Polycyclic Aromatic Hydrocarbons 121-124 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 40-46 20732958-10 2010 In conclusion, the results suggest that CYP1A2 plays a pivotal role in the regulation of hepatic and pulmonary CYP1A1 by PAHs, a phenomenon that potentially has important implications for PAH-mediated carcinogenesis. Polycyclic Aromatic Hydrocarbons 121-124 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 111-117 20127859-2 2010 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1 and CYP1B1) can both detoxify PAHs and activate them to cancer-causing reactive intermediates. Polycyclic Aromatic Hydrocarbons 74-78 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-27 20127859-2 2010 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1 and CYP1B1) can both detoxify PAHs and activate them to cancer-causing reactive intermediates. Polycyclic Aromatic Hydrocarbons 74-78 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 37-43 20127859-2 2010 Cytochrome P450 1A1 and 1B1 enzymes (CYP1A1 and CYP1B1) can both detoxify PAHs and activate them to cancer-causing reactive intermediates. Polycyclic Aromatic Hydrocarbons 74-78 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 48-54 20932552-0 2010 Evaluation of the noncovalent binding interactions between polycyclic aromatic hydrocarbon metabolites and human p53 cDNA. Polycyclic Aromatic Hydrocarbons 59-90 tumor protein p53 Homo sapiens 113-116 20932552-2 2010 We investigated the noncovalent binding interactions between 11 PAH metabolites and human p53 complementary DNA (p53 cDNA) using the fluorescence displacement method and molecular docking analysis. Polycyclic Aromatic Hydrocarbons 64-67 tumor protein p53 Homo sapiens 90-93 20932552-2 2010 We investigated the noncovalent binding interactions between 11 PAH metabolites and human p53 complementary DNA (p53 cDNA) using the fluorescence displacement method and molecular docking analysis. Polycyclic Aromatic Hydrocarbons 64-67 tumor protein p53 Homo sapiens 113-116 21072210-13 2010 AHR is a transcription factor activated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polycyclic aromatic hydrocarbons and other ligands. Polycyclic Aromatic Hydrocarbons 87-119 aryl-hydrocarbon receptor Mus musculus 0-3 20957144-8 2010 Furthermore, the stratified analysis indicated that adverse effects of XRCC1 Arg194Trp, Arg399Gln polymorphisms on PAH-DNA adducts were detected only in the high PAHs exposure group. Polycyclic Aromatic Hydrocarbons 162-166 X-ray repair cross complementing 1 Homo sapiens 71-76 20957144-9 2010 CONCLUSIONS/SIGNIFICANCE: These findings provided the first evidence that polymorphisms of XRCC1 may modify sperm PAH-DNA adduct levels and may be useful biomarkers to identify individuals susceptible to DNA damage resulting from PAHs exposure. Polycyclic Aromatic Hydrocarbons 114-117 X-ray repair cross complementing 1 Homo sapiens 91-96 20957144-9 2010 CONCLUSIONS/SIGNIFICANCE: These findings provided the first evidence that polymorphisms of XRCC1 may modify sperm PAH-DNA adduct levels and may be useful biomarkers to identify individuals susceptible to DNA damage resulting from PAHs exposure. Polycyclic Aromatic Hydrocarbons 230-234 X-ray repair cross complementing 1 Homo sapiens 91-96 20720205-4 2010 7,12-Dimethylbenz[a]anthracene (DMBA), a prototypical polycyclic aromatic hydrocarbon, activates caspase-3 in pro/pre-B cells in a bone marrow stromal cell-dependent manner, resulting in apoptosis. Polycyclic Aromatic Hydrocarbons 54-85 caspase 3 Homo sapiens 97-106 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 64-95 aryl hydrocarbon receptor 1a Danio rerio 146-171 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 64-95 aryl hydrocarbon receptor 1a Danio rerio 173-176 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 64-95 aryl hydrocarbon receptor 1a Danio rerio 219-222 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 64-95 peptidylprolyl isomerase Aa (cyclophilin A) Danio rerio 255-272 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 64-95 peptidylprolyl isomerase Aa (cyclophilin A) Danio rerio 274-278 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 97-100 aryl hydrocarbon receptor 1a Danio rerio 146-171 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 97-100 aryl hydrocarbon receptor 1a Danio rerio 173-176 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 97-100 aryl hydrocarbon receptor 1a Danio rerio 219-222 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 97-100 peptidylprolyl isomerase Aa (cyclophilin A) Danio rerio 255-272 20674047-1 2010 Endpoints of planar halogenated aromatic hydrocarbon (pHAH) and polycyclic aromatic hydrocarbon (PAH) toxicity are mediated via activation of the aryl hydrocarbon receptor (AhR) followed by activation of the so called "AhR-battery" of genes including the cytochrome P450 1 (CYP1) isoforms. Polycyclic Aromatic Hydrocarbons 97-100 peptidylprolyl isomerase Aa (cyclophilin A) Danio rerio 274-278 19942646-10 2010 Approximately 4.6 and 2.2% of the total initial amounts of studied PAHs in the soil were leached in columns B1 and B2, respectively. Polycyclic Aromatic Hydrocarbons 67-71 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 108-117 20621368-0 2010 Expression of CYP1C1 and CYP1A in Fundulus heteroclitus during PAH-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 63-66 cytochrome P450 1A1 Fundulus heteroclitus 25-30 20621368-2 2010 However, CYP1C1"s expression and physiological roles relative to the more recognized CYP1A in polycyclic aromatic hydrocarbons (PAHs) induced toxicities are unclear. Polycyclic Aromatic Hydrocarbons 128-132 cytochrome P450 1A1 Fundulus heteroclitus 85-90 20674550-4 2010 In a genome-wide P450 microarray screen, we identified six PAH-responsive P450 genes (Pc-pah1-Pc-pah6) inducible by PAHs of varying ring size, namely naphthalene, phenanthrene, pyrene, and benzo(a)pyrene (BaP). Polycyclic Aromatic Hydrocarbons 59-62 prohibitin 2 Homo sapiens 205-208 20674550-4 2010 In a genome-wide P450 microarray screen, we identified six PAH-responsive P450 genes (Pc-pah1-Pc-pah6) inducible by PAHs of varying ring size, namely naphthalene, phenanthrene, pyrene, and benzo(a)pyrene (BaP). Polycyclic Aromatic Hydrocarbons 116-120 prohibitin 2 Homo sapiens 205-208 20542099-3 2010 When analyzing the effect of BaP on the induction of CYP1 enzymes participating in the metabolic activation of PAHs in LNCaP cells, we found that BaP induced expression of CYP1A1 and CYP1A2, but not CYP1B1 enzyme. Polycyclic Aromatic Hydrocarbons 111-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-57 20542099-3 2010 When analyzing the effect of BaP on the induction of CYP1 enzymes participating in the metabolic activation of PAHs in LNCaP cells, we found that BaP induced expression of CYP1A1 and CYP1A2, but not CYP1B1 enzyme. Polycyclic Aromatic Hydrocarbons 111-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 172-178 20542099-3 2010 When analyzing the effect of BaP on the induction of CYP1 enzymes participating in the metabolic activation of PAHs in LNCaP cells, we found that BaP induced expression of CYP1A1 and CYP1A2, but not CYP1B1 enzyme. Polycyclic Aromatic Hydrocarbons 111-115 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 183-189 20663510-9 2010 The relative standard deviations (RSD) for 0.01microgL(-1) of PAHs in tap water were in the range of 5.1-10.0%. Polycyclic Aromatic Hydrocarbons 62-66 nuclear RNA export factor 1 Homo sapiens 70-73 20562217-4 2010 We demonstrate that human PGC numbers are specifically reduced by exposure to polycyclic aromatic hydrocarbons (PAHs), a group of toxicants common in air pollutants released from gasoline combustion or tobacco smoke. Polycyclic Aromatic Hydrocarbons 78-110 progastricsin Homo sapiens 26-29 20562217-4 2010 We demonstrate that human PGC numbers are specifically reduced by exposure to polycyclic aromatic hydrocarbons (PAHs), a group of toxicants common in air pollutants released from gasoline combustion or tobacco smoke. Polycyclic Aromatic Hydrocarbons 112-116 progastricsin Homo sapiens 26-29 20562217-5 2010 Further, we demonstrate that the adverse effects of PAH exposure are mediated through the aromatic hydrocarbon receptor (AHR) and BAX pathway. Polycyclic Aromatic Hydrocarbons 52-55 aryl hydrocarbon receptor Homo sapiens 90-119 20562217-5 2010 Further, we demonstrate that the adverse effects of PAH exposure are mediated through the aromatic hydrocarbon receptor (AHR) and BAX pathway. Polycyclic Aromatic Hydrocarbons 52-55 aryl hydrocarbon receptor Homo sapiens 121-124 20562217-5 2010 Further, we demonstrate that the adverse effects of PAH exposure are mediated through the aromatic hydrocarbon receptor (AHR) and BAX pathway. Polycyclic Aromatic Hydrocarbons 52-55 BCL2 associated X, apoptosis regulator Homo sapiens 130-133 20377843-9 2010 Mutant experiments showed that PAH inhibits growth through an ethylene-independent pathway, as PAH-treated ethylene-insensitive etr1-4 mutants exhibited a greater growth reduction than WT. Polycyclic Aromatic Hydrocarbons 31-34 Signal transduction histidine kinase, hybrid-type, ethylene sensor Arabidopsis thaliana 128-132 20605646-0 2010 AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic killifish (Fundulus heteroclitus). Polycyclic Aromatic Hydrocarbons 39-71 aryl hydrocarbon receptor-like Fundulus heteroclitus 0-4 20605646-8 2010 These data demonstrate that AHR2 is the primary mediator of cardiac teratogenesis caused by multiple aryl hydrocarbons in Fundulus and suggest that suppression of the AHR pathway through modulation of AHR2 is a plausible mechanism for PAH resistance in adapted fish. Polycyclic Aromatic Hydrocarbons 235-238 aryl hydrocarbon receptor-like Fundulus heteroclitus 28-32 20605646-8 2010 These data demonstrate that AHR2 is the primary mediator of cardiac teratogenesis caused by multiple aryl hydrocarbons in Fundulus and suggest that suppression of the AHR pathway through modulation of AHR2 is a plausible mechanism for PAH resistance in adapted fish. Polycyclic Aromatic Hydrocarbons 235-238 aryl hydrocarbon receptor-like Fundulus heteroclitus 201-205 20464547-4 2010 The data of RT-PCR analysis indicated that treatments of human lung adenocarcinoma CL5 cells with benzo(a)pyrene and a PAH mixture motorcycle exhaust particulate (MEP) extracts increased FGF-9 mRNA expression. Polycyclic Aromatic Hydrocarbons 119-122 fibroblast growth factor 9 Homo sapiens 187-192 20229026-0 2010 Modulation of ethoxyresorufin O-deethylase and glutathione S-transferase activities in Nile tilapia (Oreochromis niloticus) by polycyclic aromatic hydrocarbons containing two to four rings: implications in biomonitoring aquatic pollution. Polycyclic Aromatic Hydrocarbons 127-159 glutathione S-transferase Oreochromis niloticus 47-72 20229026-2 2010 In the present study, effects of five PAHs containing two to four aromatic rings on hepatic CYP1A dependent ethoxyresorufin O-deethylase (EROD), glutathione S-transferase (GST) and serum sorbitol dehydrogenase (SDH) activities in Nile tilapia, a potential fish species for biomonitoring pollution in tropical waters, were evaluated. Polycyclic Aromatic Hydrocarbons 38-42 cytochrome P450 1A Oreochromis niloticus 92-97 20307928-5 2010 Under all tested loads, the average concentrations of total-PAHs emitted from the generator using the B10 and B20 were lower (by 38% and 28%, respectively) than those using pure petroleum diesel fuel (B0), while the emission factors of total-PAHs decreased with an increasing ratio of biodiesel to premium diesel. Polycyclic Aromatic Hydrocarbons 60-64 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 102-105 20054638-2 2010 The metabolism of polycyclic aromatic hydrocarbons and other procarcinogens through CYP1B1 may well lead to their activation. Polycyclic Aromatic Hydrocarbons 18-50 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 84-90 20700368-2 2010 Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 133-165 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 5-23 20700368-2 2010 Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 133-165 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 20700368-2 2010 Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 133-165 glutathione S-transferase mu 1 Homo sapiens 37-65 20700368-2 2010 Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 133-165 glutathione S-transferase mu 1 Homo sapiens 67-72 20106901-1 2010 The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, which is activated by a large group of environmental pollutants including polycyclic aromatic hydrocarbons, dioxins and planar polychlorinated biphenyls. Polycyclic Aromatic Hydrocarbons 154-186 aryl hydrocarbon receptor Homo sapiens 4-29 20106901-1 2010 The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor, which is activated by a large group of environmental pollutants including polycyclic aromatic hydrocarbons, dioxins and planar polychlorinated biphenyls. Polycyclic Aromatic Hydrocarbons 154-186 aryl hydrocarbon receptor Homo sapiens 31-34 20663163-0 2010 Polycyclic aromatic hydrocarbon components contribute to the mitochondria-antiapoptotic effect of fine particulate matter on human bronchial epithelial cells via the aryl hydrocarbon receptor. Polycyclic Aromatic Hydrocarbons 0-31 aryl hydrocarbon receptor Homo sapiens 166-191 20381959-3 2010 Biosorption and biodegradation of PAHs by live and heat-killed white-rot fungi (CW-1) were investigated to elucidate the bio-dissipation mechanisms of PAHs. Polycyclic Aromatic Hydrocarbons 34-38 dynein light chain Tctex-type 1 Homo sapiens 80-84 20381959-3 2010 Biosorption and biodegradation of PAHs by live and heat-killed white-rot fungi (CW-1) were investigated to elucidate the bio-dissipation mechanisms of PAHs. Polycyclic Aromatic Hydrocarbons 151-155 dynein light chain Tctex-type 1 Homo sapiens 80-84 20395310-1 2010 X-ray repair cross-complementing group 1 (XRCC1) plays a role in repairing polycyclic aromatic hydrocarbons (PAHs)-induced DNA damage. Polycyclic Aromatic Hydrocarbons 75-107 X-ray repair cross complementing 1 Homo sapiens 0-40 20395310-1 2010 X-ray repair cross-complementing group 1 (XRCC1) plays a role in repairing polycyclic aromatic hydrocarbons (PAHs)-induced DNA damage. Polycyclic Aromatic Hydrocarbons 75-107 X-ray repair cross complementing 1 Homo sapiens 42-47 20395310-1 2010 X-ray repair cross-complementing group 1 (XRCC1) plays a role in repairing polycyclic aromatic hydrocarbons (PAHs)-induced DNA damage. Polycyclic Aromatic Hydrocarbons 109-113 X-ray repair cross complementing 1 Homo sapiens 0-40 20395310-1 2010 X-ray repair cross-complementing group 1 (XRCC1) plays a role in repairing polycyclic aromatic hydrocarbons (PAHs)-induced DNA damage. Polycyclic Aromatic Hydrocarbons 109-113 X-ray repair cross complementing 1 Homo sapiens 42-47 20353797-10 2010 p53 was also induced by NaAsO(2) (As(3)(+)) and PAHs alone or in combination. Polycyclic Aromatic Hydrocarbons 48-52 transformation related protein 53, pseudogene Mus musculus 0-3 20353797-12 2010 PAH metabolites were found to be more potent than parent compounds in producing immunosuppression and inducing p53 expression. Polycyclic Aromatic Hydrocarbons 0-3 transformation related protein 53, pseudogene Mus musculus 111-114 20596254-1 2010 PURPOSE: Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 142-174 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-32 20596254-1 2010 PURPOSE: Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 142-174 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 20596254-1 2010 PURPOSE: Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 142-174 glutathione S-transferase mu 1 Homo sapiens 46-74 20596254-1 2010 PURPOSE: Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 142-174 glutathione S-transferase mu 1 Homo sapiens 76-81 20596254-1 2010 PURPOSE: Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 176-180 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-32 20596254-1 2010 PURPOSE: Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 176-180 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 20596254-1 2010 PURPOSE: Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 176-180 glutathione S-transferase mu 1 Homo sapiens 46-74 20596254-1 2010 PURPOSE: Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 176-180 glutathione S-transferase mu 1 Homo sapiens 76-81 20307623-8 2010 The results of this experiment indicate that BaP, an AhR agonist, can significantly increase receptor and CYP1A1 expression and induce oxidative stress in human skin, confirming the involvement of this pathway in the pathogenesis of tissue damage due to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 254-286 aryl hydrocarbon receptor Homo sapiens 53-56 20051482-1 2010 Cytochrome P450 (P450)1A1 plays a critical role in the metabolic activation and detoxification of polycyclic aromatic hydrocarbons (PAHs), many of which are potent human carcinogens. Polycyclic Aromatic Hydrocarbons 98-130 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-25 20051482-1 2010 Cytochrome P450 (P450)1A1 plays a critical role in the metabolic activation and detoxification of polycyclic aromatic hydrocarbons (PAHs), many of which are potent human carcinogens. Polycyclic Aromatic Hydrocarbons 132-136 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-25 19365803-0 2010 Differential action of chlorinated polycyclic aromatic hydrocarbons on aryl hydrocarbon receptor-mediated signaling in breast cancer cells. Polycyclic Aromatic Hydrocarbons 35-67 aryl hydrocarbon receptor Homo sapiens 71-96 19365803-4 2010 For the targeted ClPAHs, Western blot analysis of ClPAH-induced CYP1A1 and 1B1 showed an enhancement in activities in comparison with induction by the corresponding parent PAHs, and the effects of chlorination were especially prominent in phenanthrene. Polycyclic Aromatic Hydrocarbons 19-23 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 64-78 20064791-0 2010 Associations between polycyclic aromatic hydrocarbon-related exposures and p53 mutations in breast tumors. Polycyclic Aromatic Hydrocarbons 21-52 tumor protein p53 Homo sapiens 75-78 20371965-9 2010 These results strongly suggest that the suppression of MDA-LDL-induced THP-1 cell growth is caused by the increased uptake of PAHs, which strongly activate the AhR signal pathway accompanying DNA damage. Polycyclic Aromatic Hydrocarbons 126-130 aryl hydrocarbon receptor Homo sapiens 160-163 20377843-9 2010 Mutant experiments showed that PAH inhibits growth through an ethylene-independent pathway, as PAH-treated ethylene-insensitive etr1-4 mutants exhibited a greater growth reduction than WT. Polycyclic Aromatic Hydrocarbons 95-98 Signal transduction histidine kinase, hybrid-type, ethylene sensor Arabidopsis thaliana 128-132 20080079-6 2010 As they contain inducers of cytochrome P450 1A1 (CYP1A1), we explored the activity of CYP1A1-related enzymes, i.e. 7-ethoxycoumarin- and 7-ethoxyresorufin-O-deethylase (ECOD and EROD) in both cell systems in basal conditions and after exposure to non-cytotoxic doses of beta-naphthoflavone (BNF), a well-known PAH-type inducer. Polycyclic Aromatic Hydrocarbons 310-313 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 20080079-6 2010 As they contain inducers of cytochrome P450 1A1 (CYP1A1), we explored the activity of CYP1A1-related enzymes, i.e. 7-ethoxycoumarin- and 7-ethoxyresorufin-O-deethylase (ECOD and EROD) in both cell systems in basal conditions and after exposure to non-cytotoxic doses of beta-naphthoflavone (BNF), a well-known PAH-type inducer. Polycyclic Aromatic Hydrocarbons 310-313 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 20334656-1 2010 BACKGROUND: The AhR is a ligand-activated transcription factor that mediates immunosuppression induced by environmental PAH and HAH. Polycyclic Aromatic Hydrocarbons 120-123 aryl hydrocarbon receptor Homo sapiens 16-19 20334656-11 2010 CONCLUSIONS: 1) Extensive proliferation is not required during the differentiation phase per se for CD40L-activated human B cells to undergo plasma cell differentiation, and 2) an environmental PAH blocks both proliferation and differentiation of AhR expressing B cells. Polycyclic Aromatic Hydrocarbons 194-197 aryl hydrocarbon receptor Homo sapiens 247-250 20117208-1 2010 We previously observed a strong synergistic effect on polycyclic aromatic hydrocarbon (PAH)-induced CYP1A1 expression by andrographolide, a major constituent of an herbal medicine derived from the plant Andrographis paniculata, in mouse hepatocytes in primary culture. Polycyclic Aromatic Hydrocarbons 54-85 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 100-106 20117208-1 2010 We previously observed a strong synergistic effect on polycyclic aromatic hydrocarbon (PAH)-induced CYP1A1 expression by andrographolide, a major constituent of an herbal medicine derived from the plant Andrographis paniculata, in mouse hepatocytes in primary culture. Polycyclic Aromatic Hydrocarbons 87-90 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 100-106 20117208-2 2010 The present paper describes confirmation of an enhancing effect of andrographolide on the CYP1 family in vivo in the PAH-responsive C57BL/6 mouse. Polycyclic Aromatic Hydrocarbons 117-120 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 90-94 20821494-1 2010 Exposure to coplanar polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) can adversely affect fish embryonic development, induce expression of cytochrome P4501A (CYP1A), and increase reactive oxygen species (ROS) production, effects believed to be mediated by the aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 58-90 cytochrome P450 1A1 Fundulus heteroclitus 187-192 20821494-1 2010 Exposure to coplanar polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) can adversely affect fish embryonic development, induce expression of cytochrome P4501A (CYP1A), and increase reactive oxygen species (ROS) production, effects believed to be mediated by the aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 92-96 cytochrome P450 1A1 Fundulus heteroclitus 187-192 20821494-3 2010 We hypothesized that fish resistant to CYP1A induction would also exhibit resistance to PCB and PAH induced ROS production and teratogenesis. Polycyclic Aromatic Hydrocarbons 96-99 cytochrome P450 1A1 Fundulus heteroclitus 39-44 20821494-9 2010 These findings further our understanding of toxicant resistance by demonstrating that reduced response to coplanar PCBs and PAHs extends beyond resistance to CYP1A induction to resistance to the physiological and teratogenic effects of these toxicants, responses that undoubtedly contribute to the increased survival of killifish inhabiting contaminated sites. Polycyclic Aromatic Hydrocarbons 124-128 cytochrome P450 1A1 Fundulus heteroclitus 158-163 19822660-1 2009 Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is known to mediate a wide variety of pharmacological and toxicological effects caused by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 164-196 aryl-hydrocarbon receptor Mus musculus 0-25 20064835-2 2010 In order to identify their molecular targets in such cells, we have analyzed gene expression profile of primary human macrophages treated by the prototypical PAH benzo(a)pyrene (BaP), using pangenomic oligonucleotides microarrays. Polycyclic Aromatic Hydrocarbons 158-161 prohibitin 2 Homo sapiens 178-181 20064835-6 2010 Their bioinformatic analysis indicated that biological functions linked to immunity, inflammation, and cell death were among the most affected by BaP in human macrophages and that the AhR and p53 signaling pathways were the most significant canonical pathways activated by the PAH. Polycyclic Aromatic Hydrocarbons 277-280 prohibitin 2 Homo sapiens 146-149 20055467-1 2010 The spectroscopic properties of a novel intramolecular energy transfer probe (ET probe)--consisting of 3-hydroxybenzo[a]pyrene (3OH-BaP) as the donor covalently linked to sulforhodamine B (SRB) as the acceptor--for the detection of polycyclic aromatic hydrocarbons (PAH) antibody binding were characterized. Polycyclic Aromatic Hydrocarbons 232-264 chaperonin containing TCP1 subunit 4 Homo sapiens 171-187 20055467-1 2010 The spectroscopic properties of a novel intramolecular energy transfer probe (ET probe)--consisting of 3-hydroxybenzo[a]pyrene (3OH-BaP) as the donor covalently linked to sulforhodamine B (SRB) as the acceptor--for the detection of polycyclic aromatic hydrocarbons (PAH) antibody binding were characterized. Polycyclic Aromatic Hydrocarbons 266-269 chaperonin containing TCP1 subunit 4 Homo sapiens 171-187 19367423-7 2010 Therefore, we have reviewed the scientific literature in order to indicate that air pollutants, such as particulate matter, polycyclic aromatic hydrocarbons, and gaseous matter, are Nrf2 pathway inductors, triggering self-defense through the establishment of proinflammatory and antioxidant responses. Polycyclic Aromatic Hydrocarbons 124-156 NFE2 like bZIP transcription factor 2 Homo sapiens 182-186 19860743-8 2010 The strongest and most consistent effect observed was between PAH and haplotype ACCGGC of the CYP1B1 gene. Polycyclic Aromatic Hydrocarbons 62-65 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 94-100 20843134-1 2010 The GSTP1 enzyme plays a key role in biotransformation and bioactivation of certain environmental pollutants such as benzo[a]pyrene-7, 8-diol-9,10-epoxide (BPDE) and other diol epoxides of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 189-221 glutathione S-transferase pi 1 Homo sapiens 4-9 21552507-7 2010 The dominant contributors to the total AhR activity, were found to be for compounds which are not resistant to H(2)SO(4)/silica gel treatment and were relatively rapidly metabolised that is consistent with a PAH type response. Polycyclic Aromatic Hydrocarbons 208-211 aryl hydrocarbon receptor Homo sapiens 39-42 19758578-2 2010 Because the toxic effects of many PAHs are the result of metabolism by cytochrome P4501A (CYP1A), it is important to investigate whether active forms of these enzymes can be identified in the mitochondria. Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450 1A1 Fundulus heteroclitus 71-88 19758578-2 2010 Because the toxic effects of many PAHs are the result of metabolism by cytochrome P4501A (CYP1A), it is important to investigate whether active forms of these enzymes can be identified in the mitochondria. Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450 1A1 Fundulus heteroclitus 90-95 19758578-7 2010 However, fish from a PAH-polluted Superfund site (Elizabeth River, Portsmouth VA) showed recalcitrant mitochondrial CYP1A protein levels and enzyme activity in a similar manner to microsomal CYP1A. Polycyclic Aromatic Hydrocarbons 21-24 cytochrome P450 1A1 Fundulus heteroclitus 116-121 19758578-7 2010 However, fish from a PAH-polluted Superfund site (Elizabeth River, Portsmouth VA) showed recalcitrant mitochondrial CYP1A protein levels and enzyme activity in a similar manner to microsomal CYP1A. Polycyclic Aromatic Hydrocarbons 21-24 cytochrome P450 1A1 Fundulus heteroclitus 191-196 19836015-0 2010 Association of urinary polycyclic aromatic hydrocarbons and serum C-reactive protein. Polycyclic Aromatic Hydrocarbons 23-55 C-reactive protein Homo sapiens 66-84 19950922-3 2010 Accumulation of the polycyclic aromatic hydrocarbons (PAHs) naphthalene (Nap), phenanthrene (Phe), pyrene (Pyr), and benz(a)pyrene (Bap) by PECAM was compared with their uptake by plants. Polycyclic Aromatic Hydrocarbons 20-52 prohibitin 2 Homo sapiens 132-135 19608585-2 2010 Phase I enzymes, including cytochrome P(450), family 1, subfamily A, polypeptide 1 (CYP1A1), are involved in the activation of carcinogens, such as polycyclic aromatic hydrocarbons, to reactive intermediates that are capable of binding covalently to DNA to form DNA adducts, potentially initiating the carcinogenic process. Polycyclic Aromatic Hydrocarbons 148-180 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 27-82 19608585-2 2010 Phase I enzymes, including cytochrome P(450), family 1, subfamily A, polypeptide 1 (CYP1A1), are involved in the activation of carcinogens, such as polycyclic aromatic hydrocarbons, to reactive intermediates that are capable of binding covalently to DNA to form DNA adducts, potentially initiating the carcinogenic process. Polycyclic Aromatic Hydrocarbons 148-180 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 84-90 20064835-6 2010 Their bioinformatic analysis indicated that biological functions linked to immunity, inflammation, and cell death were among the most affected by BaP in human macrophages and that the AhR and p53 signaling pathways were the most significant canonical pathways activated by the PAH. Polycyclic Aromatic Hydrocarbons 277-280 aryl hydrocarbon receptor Homo sapiens 184-187 20064835-6 2010 Their bioinformatic analysis indicated that biological functions linked to immunity, inflammation, and cell death were among the most affected by BaP in human macrophages and that the AhR and p53 signaling pathways were the most significant canonical pathways activated by the PAH. Polycyclic Aromatic Hydrocarbons 277-280 tumor protein p53 Homo sapiens 192-195 20064835-7 2010 AhR and p53 implications were moreover fully confirmed by the prevention of BaP-related upregulation of some selected target genes by AhR silencing or the use of pifithrin-alpha, an inhibitor of PAH bioactivation-related DNA damage/p53 pathways. Polycyclic Aromatic Hydrocarbons 195-198 aryl hydrocarbon receptor Homo sapiens 0-3 20064835-7 2010 AhR and p53 implications were moreover fully confirmed by the prevention of BaP-related upregulation of some selected target genes by AhR silencing or the use of pifithrin-alpha, an inhibitor of PAH bioactivation-related DNA damage/p53 pathways. Polycyclic Aromatic Hydrocarbons 195-198 tumor protein p53 Homo sapiens 8-11 20064835-7 2010 AhR and p53 implications were moreover fully confirmed by the prevention of BaP-related upregulation of some selected target genes by AhR silencing or the use of pifithrin-alpha, an inhibitor of PAH bioactivation-related DNA damage/p53 pathways. Polycyclic Aromatic Hydrocarbons 195-198 prohibitin 2 Homo sapiens 76-79 19892797-7 2010 Cokeoven workers were heavily exposed to PAHs (79% exceeded the urinary 1-pyrenol biological exposure index) and exhibited lower TL (P = 0.038) than controls, as well as higher levels of genetic and chromosomal alterations [i.e. anti-BPDE-DNA adduct and MN (P < 0.0001)] and epigenetic changes [i.e. p53 gene-specific promoter and global methylation (P <or= 0.001)]. Polycyclic Aromatic Hydrocarbons 41-45 tumor protein p53 Homo sapiens 303-306 20055402-11 2010 Conversion efficiencies varied for individual PAHs and were lower for lox- (eta = 0.31-0.87) than for hox-DPFs (eta = 0.75-0.98). Polycyclic Aromatic Hydrocarbons 46-50 lysyl oxidase Homo sapiens 70-73 19737606-0 2010 Identification of AhR-regulated genes involved in PAH-induced immunotoxicity using a highly-sensitive DNA chip, 3D-Gene Human Immunity and Metabolic Syndrome 9k. Polycyclic Aromatic Hydrocarbons 50-53 aryl hydrocarbon receptor Homo sapiens 18-21 19737606-3 2010 The purpose of this study was to identify novel aryl hydrocarbon receptor (AhR)-regulated genes involved in PAH-induced immunotoxicity using a highly-sensitive DNA chip, 3D-Gene(TM) Human Immunity & Metabolic Syndrome 9k. Polycyclic Aromatic Hydrocarbons 108-111 aryl hydrocarbon receptor Homo sapiens 48-73 19737606-3 2010 The purpose of this study was to identify novel aryl hydrocarbon receptor (AhR)-regulated genes involved in PAH-induced immunotoxicity using a highly-sensitive DNA chip, 3D-Gene(TM) Human Immunity & Metabolic Syndrome 9k. Polycyclic Aromatic Hydrocarbons 108-111 aryl hydrocarbon receptor Homo sapiens 75-78 20389043-1 2010 Polycyclic aromatic hydrocarbons (PAH) such as dibenzo[a,l]pyrene (DBP) are wide-spread environmental pollutants most probably mutagenic and carcinogenic to humans. Polycyclic Aromatic Hydrocarbons 0-32 D-box binding PAR bZIP transcription factor Homo sapiens 67-70 20389043-1 2010 Polycyclic aromatic hydrocarbons (PAH) such as dibenzo[a,l]pyrene (DBP) are wide-spread environmental pollutants most probably mutagenic and carcinogenic to humans. Polycyclic Aromatic Hydrocarbons 34-37 D-box binding PAR bZIP transcription factor Homo sapiens 67-70 20391135-5 2010 In addition, the inflammatory cell response to PAH insult was examined through interleukin-1 (IL-1) alpha and interleukin-6 (IL-6) secretion. Polycyclic Aromatic Hydrocarbons 47-50 interleukin 1 alpha Homo sapiens 79-92 20391135-5 2010 In addition, the inflammatory cell response to PAH insult was examined through interleukin-1 (IL-1) alpha and interleukin-6 (IL-6) secretion. Polycyclic Aromatic Hydrocarbons 47-50 interleukin 1 alpha Homo sapiens 94-105 20391135-5 2010 In addition, the inflammatory cell response to PAH insult was examined through interleukin-1 (IL-1) alpha and interleukin-6 (IL-6) secretion. Polycyclic Aromatic Hydrocarbons 47-50 interleukin 6 Homo sapiens 110-123 20391135-5 2010 In addition, the inflammatory cell response to PAH insult was examined through interleukin-1 (IL-1) alpha and interleukin-6 (IL-6) secretion. Polycyclic Aromatic Hydrocarbons 47-50 interleukin 6 Homo sapiens 125-129 19722178-4 2010 We investigated the influence of occupational PAH on the frequency and spectrum of FGFR3 mutations. Polycyclic Aromatic Hydrocarbons 46-49 fibroblast growth factor receptor 3 Homo sapiens 83-88 19900403-2 2009 Cytochrome P450 (CYP)1A enzymes play key roles in the metabolic activation of PAHs to carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 78-82 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 0-23 20003407-8 2009 The soils from localities at higher altitudes above sea level have the highest PAH concentrations, and the PAH concentrations decrease with increasing distance from the town. Polycyclic Aromatic Hydrocarbons 79-82 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 52-55 19786002-1 2009 BACKGROUND: The CYP1A1 gene is a polymorphic gene and encodes for the CYP1A1 enzyme that catalyzes the bioactivation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 120-152 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-22 19786002-1 2009 BACKGROUND: The CYP1A1 gene is a polymorphic gene and encodes for the CYP1A1 enzyme that catalyzes the bioactivation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 120-152 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 70-76 19786002-1 2009 BACKGROUND: The CYP1A1 gene is a polymorphic gene and encodes for the CYP1A1 enzyme that catalyzes the bioactivation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 154-158 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-22 19786002-1 2009 BACKGROUND: The CYP1A1 gene is a polymorphic gene and encodes for the CYP1A1 enzyme that catalyzes the bioactivation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 154-158 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 70-76 19643601-3 2009 The glutathione S-transferase P1 gene (GSTP1) is a particularly attractive candidate for colorectal cancer susceptibility because it codes the enzyme involved in the metabolism of environmental carcinogens such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 214-246 glutathione S-transferase pi 1 Homo sapiens 4-32 19643601-3 2009 The glutathione S-transferase P1 gene (GSTP1) is a particularly attractive candidate for colorectal cancer susceptibility because it codes the enzyme involved in the metabolism of environmental carcinogens such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 214-246 glutathione S-transferase pi 1 Homo sapiens 39-44 19643601-3 2009 The glutathione S-transferase P1 gene (GSTP1) is a particularly attractive candidate for colorectal cancer susceptibility because it codes the enzyme involved in the metabolism of environmental carcinogens such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 248-252 glutathione S-transferase pi 1 Homo sapiens 4-32 19643601-3 2009 The glutathione S-transferase P1 gene (GSTP1) is a particularly attractive candidate for colorectal cancer susceptibility because it codes the enzyme involved in the metabolism of environmental carcinogens such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 248-252 glutathione S-transferase pi 1 Homo sapiens 39-44 20187407-5 2009 In the light of these, catalase was relatively more sensitive to phenanthrene than the other enzymes, and could be employed as a key indicator to evaluate the risk of polycyclic aromatic hydrocarbon contaminated soil during remedying. Polycyclic Aromatic Hydrocarbons 167-198 catalase-1 Triticum aestivum 23-31 19822660-1 2009 Aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, is known to mediate a wide variety of pharmacological and toxicological effects caused by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 164-196 aryl-hydrocarbon receptor Mus musculus 27-30 19930591-1 2009 BACKGROUND: The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 226-258 ATP binding cassette subfamily B member 1 Homo sapiens 41-63 19930591-1 2009 BACKGROUND: The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 226-258 ATP binding cassette subfamily B member 1 Homo sapiens 65-69 19930591-1 2009 BACKGROUND: The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 226-258 ATP binding cassette subfamily B member 1 Homo sapiens 70-75 19930591-1 2009 BACKGROUND: The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 226-258 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 81-113 19930591-1 2009 BACKGROUND: The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 226-258 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 115-119 19930591-1 2009 BACKGROUND: The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 226-258 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 120-125 19930591-1 2009 BACKGROUND: The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 260-263 ATP binding cassette subfamily B member 1 Homo sapiens 41-63 19930591-1 2009 BACKGROUND: The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 260-263 ATP binding cassette subfamily B member 1 Homo sapiens 65-69 19930591-1 2009 BACKGROUND: The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 260-263 ATP binding cassette subfamily B member 1 Homo sapiens 70-75 19930591-1 2009 BACKGROUND: The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 260-263 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 81-113 19930591-1 2009 BACKGROUND: The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 260-263 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 115-119 19930591-1 2009 BACKGROUND: The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 260-263 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 120-125 20063724-8 2009 The results of the study demonstrated the capability of PUF PAS to monitor atmospheric PAHs in a city scale at the same time. Polycyclic Aromatic Hydrocarbons 87-91 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 56-59 21217860-1 2009 A simple and sensitive method was developed to separate the carcinogenic polycyclic aromatic hydrocarbon (PAH), benzo[a]pyrene (BaP), and six of its oxidation metabolites generated by rat hepatic microsomes enriched with cytochrome P450 (CYP) 1A1, by high pressure liquid chromatography (HPLC). Polycyclic Aromatic Hydrocarbons 73-104 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 221-246 20329532-4 2010 SigmaPAHs were significantly correlated with TOC (r = 0.699, p < 0.001), indicating that TOC was a key soil property affecting the level and fate of PAHs in sediments. Polycyclic Aromatic Hydrocarbons 5-9 rhomboid 5 homolog 2 Homo sapiens 92-95 19882627-5 2009 The separation of the polycyclic aromatic hydrocarbon test mixture using current methodologies (i.e. a C18/ACN combination) had a CED of 1.13 MJ-eq, and a peak capacity of 27 peaks (resolving 7 of 12 peak pairs with R(s)>1). Polycyclic Aromatic Hydrocarbons 22-53 Bardet-Biedl syndrome 9 Homo sapiens 103-106 19545876-9 2009 Results confirmed that Sil-VOD23 showed much higher selectivity for PAH isomers than ODS, but lower than Sil-ODA25. Polycyclic Aromatic Hydrocarbons 68-71 STIL centriolar assembly protein Homo sapiens 23-26 19545876-11 2009 These results indicate that carbonyl groups in Sil-VOD23 are effective for molecular shape recognition of PAHs through carbonyl-pi interactions even in the disordered state. Polycyclic Aromatic Hydrocarbons 106-110 STIL centriolar assembly protein Homo sapiens 47-50 19726680-1 2009 Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by aldo-keto reductases are ligands for the aryl hydrocarbon receptor (AhR) (Burczynski, M. E., and Penning, T. M. (2000) Cancer Res. Polycyclic Aromatic Hydrocarbons 0-31 aryl hydrocarbon receptor Homo sapiens 102-127 19726680-1 2009 Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by aldo-keto reductases are ligands for the aryl hydrocarbon receptor (AhR) (Burczynski, M. E., and Penning, T. M. (2000) Cancer Res. Polycyclic Aromatic Hydrocarbons 0-31 aryl hydrocarbon receptor Homo sapiens 129-132 19726680-4 2009 We tested whether the AhR enhances PAH o-quinone-mediated oxidative DNA damage by translocating these ligands to the nucleus. Polycyclic Aromatic Hydrocarbons 35-38 aryl hydrocarbon receptor Homo sapiens 22-25 19726680-13 2009 We conclude that the AhR shuttles PAH o-quinone genotoxins to the nucleus and enhances oxidative DNA damage. Polycyclic Aromatic Hydrocarbons 34-37 aryl hydrocarbon receptor Homo sapiens 21-24 19679040-2 2009 In this study, new polycyclic aromatic hydrocarbon (PAH) conjugates were synthesized in order to more closely mimic the endogenous ligands of the cytosolic aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 19-50 aryl hydrocarbon receptor Homo sapiens 156-181 19559082-1 2009 Polycyclic aromatic hydrocarbons such as benzo(a)pyrene (BaP) are toxic environmental contaminants known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 159-184 19559082-1 2009 Polycyclic aromatic hydrocarbons such as benzo(a)pyrene (BaP) are toxic environmental contaminants known to regulate gene expression through activation of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 186-189 19559082-7 2009 These results indicated that BaP induced NCF1/p47(phox) expression and subsequently enhanced superoxide anion production in PMA-treated human macrophages, in an AhR-dependent manner; such an NCF1/NADPH oxidase regulation by polycyclic aromatic hydrocarbons may participate in deleterious effects toward human health triggered by these environmental contaminants, including atherosclerosis and smoking-related diseases. Polycyclic Aromatic Hydrocarbons 224-256 neutrophil cytosolic factor 1 Homo sapiens 191-195 19927796-0 2009 [Over one hundred year sedimentary record of polycyclic aromatic hydrocarbons in the Andaman Sea, Malaysia]. Polycyclic Aromatic Hydrocarbons 45-77 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 93-96 19690180-1 2009 BACKGROUND: Polycyclic aromatic hydrocarbon (PAH) exposure is a risk factor for esophageal squamous cell carcinoma, and PAHs are ligands of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 12-43 aryl hydrocarbon receptor Homo sapiens 171-174 19690180-1 2009 BACKGROUND: Polycyclic aromatic hydrocarbon (PAH) exposure is a risk factor for esophageal squamous cell carcinoma, and PAHs are ligands of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 45-48 aryl hydrocarbon receptor Homo sapiens 144-169 19690180-1 2009 BACKGROUND: Polycyclic aromatic hydrocarbon (PAH) exposure is a risk factor for esophageal squamous cell carcinoma, and PAHs are ligands of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 45-48 aryl hydrocarbon receptor Homo sapiens 171-174 19486938-5 2009 The aryl hydrocarbon receptor (AhR), known to mediate most of the toxic effects of PAHs, was demonstrated to be present and functional in human MSC. Polycyclic Aromatic Hydrocarbons 83-87 aryl hydrocarbon receptor Homo sapiens 4-29 19486938-5 2009 The aryl hydrocarbon receptor (AhR), known to mediate most of the toxic effects of PAHs, was demonstrated to be present and functional in human MSC. Polycyclic Aromatic Hydrocarbons 83-87 aryl hydrocarbon receptor Homo sapiens 31-34 19463884-5 2009 The degree of enhancement of Dex-induced transactivation of the GR by PAHs, BaP approximately IND>pyrene, paralleled the potency of PAHs in activating the AhR. Polycyclic Aromatic Hydrocarbons 135-139 nuclear receptor subfamily 3 group C member 1 Homo sapiens 64-66 19463884-5 2009 The degree of enhancement of Dex-induced transactivation of the GR by PAHs, BaP approximately IND>pyrene, paralleled the potency of PAHs in activating the AhR. Polycyclic Aromatic Hydrocarbons 135-139 aryl hydrocarbon receptor Homo sapiens 158-161 19650907-3 2009 In the CD and PAH-exposed lung, CD increases apoptosis and causes alveolar type II (AT-II) cell hyperplasia but reduces CYP1A1 induction. Polycyclic Aromatic Hydrocarbons 14-17 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 120-126 19650907-7 2009 Because CYP1A1 is induced via ligand-mediated nuclear translocation of the aryl hydrocarbon receptor (AhR), we investigated the effect of CD on PAH-induced nuclear translocation of AhR in AT-II cells isolated from in vivo-exposed rats. Polycyclic Aromatic Hydrocarbons 144-147 aryl hydrocarbon receptor Rattus norvegicus 181-184 19650907-12 2009 CONCLUSION: Our findings suggest that during particle and PAH mixed exposures, CD alters the BNF-induced nuclear translocation of AhR in AT-II cells. Polycyclic Aromatic Hydrocarbons 58-61 aryl hydrocarbon receptor Rattus norvegicus 130-133 19650907-14 2009 Thus, this study suggests that mechanisms for reduced PAH-induced CYP1A1 activity in the CD exposed lung include not only the effects of inflammation on the lung as a whole, but also reduced PAH-associated nuclear translocation of AhR in an expanded population of AT-II cells. Polycyclic Aromatic Hydrocarbons 54-57 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 66-72 19650907-14 2009 Thus, this study suggests that mechanisms for reduced PAH-induced CYP1A1 activity in the CD exposed lung include not only the effects of inflammation on the lung as a whole, but also reduced PAH-associated nuclear translocation of AhR in an expanded population of AT-II cells. Polycyclic Aromatic Hydrocarbons 54-57 aryl hydrocarbon receptor Rattus norvegicus 231-234 19650907-14 2009 Thus, this study suggests that mechanisms for reduced PAH-induced CYP1A1 activity in the CD exposed lung include not only the effects of inflammation on the lung as a whole, but also reduced PAH-associated nuclear translocation of AhR in an expanded population of AT-II cells. Polycyclic Aromatic Hydrocarbons 191-194 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 66-72 19650907-14 2009 Thus, this study suggests that mechanisms for reduced PAH-induced CYP1A1 activity in the CD exposed lung include not only the effects of inflammation on the lung as a whole, but also reduced PAH-associated nuclear translocation of AhR in an expanded population of AT-II cells. Polycyclic Aromatic Hydrocarbons 191-194 aryl hydrocarbon receptor Rattus norvegicus 231-234 19362136-0 2009 The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cells. Polycyclic Aromatic Hydrocarbons 73-105 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 33-39 19362136-0 2009 The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cells. Polycyclic Aromatic Hydrocarbons 73-105 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 44-50 19362136-1 2009 Polycyclic aromatic hydrocarbons (PAHs)--environmental carcinogens--are metabolized by CYP1A1 and CYP1A2 enzymes to oxy-derivatives, which are able to bind to DNA and initiate carcinogenesis. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 87-93 19362136-1 2009 Polycyclic aromatic hydrocarbons (PAHs)--environmental carcinogens--are metabolized by CYP1A1 and CYP1A2 enzymes to oxy-derivatives, which are able to bind to DNA and initiate carcinogenesis. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 98-104 19362136-1 2009 Polycyclic aromatic hydrocarbons (PAHs)--environmental carcinogens--are metabolized by CYP1A1 and CYP1A2 enzymes to oxy-derivatives, which are able to bind to DNA and initiate carcinogenesis. Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 87-93 19362136-1 2009 Polycyclic aromatic hydrocarbons (PAHs)--environmental carcinogens--are metabolized by CYP1A1 and CYP1A2 enzymes to oxy-derivatives, which are able to bind to DNA and initiate carcinogenesis. Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 98-104 19362136-2 2009 PAHs induce CYP1A1 and CYP1A2 activity, which increases the risk of development of carcinogenesis. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-18 19362136-2 2009 PAHs induce CYP1A1 and CYP1A2 activity, which increases the risk of development of carcinogenesis. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 23-29 19362136-4 2009 In this paper we report our study of the ability of ITCs: sulforaphane and its analogues: isothiocyanate-2-oxohexyl and alyssin, to inhibit CYP1A1 and CYP1A2 enzyme activity induced by the PAHs, anthracene (ANT) and dibenzo[a,h]anthracene (DBA) in human breast cancer cell line Mcf7. Polycyclic Aromatic Hydrocarbons 189-193 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 140-146 19362136-4 2009 In this paper we report our study of the ability of ITCs: sulforaphane and its analogues: isothiocyanate-2-oxohexyl and alyssin, to inhibit CYP1A1 and CYP1A2 enzyme activity induced by the PAHs, anthracene (ANT) and dibenzo[a,h]anthracene (DBA) in human breast cancer cell line Mcf7. Polycyclic Aromatic Hydrocarbons 189-193 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 151-157 19121891-5 2009 In this work, five surfactants, namely Brij 35, Tergitol NP10, Tween 20, Tween 80 and Tyloxapol, are evaluated on the desorption of PAHs [benzanthracene (BzA), fluoranthene (FLU), and pyrene (PYR), single and in mixture] from a model sample such as kaolin. Polycyclic Aromatic Hydrocarbons 132-136 nuclear receptor subfamily 4 group A member 1 Homo sapiens 57-61 19419724-2 2009 The chromatographic property of Sil-CEA was examined by applying polycyclic aromatic hydrocarbons as solutes. Polycyclic Aromatic Hydrocarbons 65-97 STIL centriolar assembly protein Homo sapiens 32-35 19419724-2 2009 The chromatographic property of Sil-CEA was examined by applying polycyclic aromatic hydrocarbons as solutes. Polycyclic Aromatic Hydrocarbons 65-97 CEA cell adhesion molecule 3 Homo sapiens 36-39 24031437-1 2009 Benzo [a] Pyrene (BaP) is a highly recalcitrant, polycyclic aromatic hydrocarbon (PAH) with high genotoxicity and carcinogenicity. Polycyclic Aromatic Hydrocarbons 49-80 prohibitin 2 Homo sapiens 18-21 24031437-1 2009 Benzo [a] Pyrene (BaP) is a highly recalcitrant, polycyclic aromatic hydrocarbon (PAH) with high genotoxicity and carcinogenicity. Polycyclic Aromatic Hydrocarbons 82-85 prohibitin 2 Homo sapiens 18-21 19736056-8 2009 CONCLUSIONS: CYP1B1 activates chemicals such as polycyclic aromatic hydrocarbons and dioxins to create oxidized, reactive intermediates, and higher gene activity has been shown for the G allele. Polycyclic Aromatic Hydrocarbons 48-80 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 13-19 19789301-2 2009 UVR-mediated activation of the aryl hydrocarbon receptor (AhR) stimulates the transcription of CYP1A1 and CYP1B1, which encode proteins that convert PAH to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 149-152 aryl hydrocarbon receptor Homo sapiens 31-56 19789301-2 2009 UVR-mediated activation of the aryl hydrocarbon receptor (AhR) stimulates the transcription of CYP1A1 and CYP1B1, which encode proteins that convert PAH to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 149-152 aryl hydrocarbon receptor Homo sapiens 58-61 19789301-2 2009 UVR-mediated activation of the aryl hydrocarbon receptor (AhR) stimulates the transcription of CYP1A1 and CYP1B1, which encode proteins that convert PAH to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 149-152 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 95-101 19789301-2 2009 UVR-mediated activation of the aryl hydrocarbon receptor (AhR) stimulates the transcription of CYP1A1 and CYP1B1, which encode proteins that convert PAH to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 149-152 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 106-112 19789301-11 2009 Collectively, these results suggest that sunlight may activate AhR signaling and thereby sensitize cells to PAH-mediated DNA adduct formation. Polycyclic Aromatic Hydrocarbons 108-111 aryl hydrocarbon receptor Homo sapiens 63-66 19616780-2 2009 The retention behaviors of the column packed with Sil-Ala(22) were investigated by using alkylbenzenes and polycyclic aromatic hydrocarbons as injection samples in liquid chromatography. Polycyclic Aromatic Hydrocarbons 107-139 STIL centriolar assembly protein Homo sapiens 50-53 19542228-1 2009 Human polymerase kappa (hPol kappa) is one of four eukaryotic Y-class DNA polymerases and may be an important element in the cellular response to polycyclic aromatic hydrocarbons such as benzo[a]pyrene, which can lead to reactive oxygenated metabolite-mediated oxidative stress. Polycyclic Aromatic Hydrocarbons 146-178 DNA polymerase lambda Homo sapiens 24-34 19463884-1 2009 Pyrene, benzo[a]pyrene (BaP), and indeno[1,2,3-cd]pyrene (IND) are poly cyclic aromatic hydrocarbons (PAHs) with four to six annealed phenyl rings. Polycyclic Aromatic Hydrocarbons 67-100 prohibitin 2 Homo sapiens 24-27 19463884-1 2009 Pyrene, benzo[a]pyrene (BaP), and indeno[1,2,3-cd]pyrene (IND) are poly cyclic aromatic hydrocarbons (PAHs) with four to six annealed phenyl rings. Polycyclic Aromatic Hydrocarbons 102-106 prohibitin 2 Homo sapiens 24-27 19463884-5 2009 The degree of enhancement of Dex-induced transactivation of the GR by PAHs, BaP approximately IND>pyrene, paralleled the potency of PAHs in activating the AhR. Polycyclic Aromatic Hydrocarbons 70-74 nuclear receptor subfamily 3 group C member 1 Homo sapiens 64-66 19497421-0 2009 The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells. Polycyclic Aromatic Hydrocarbons 99-131 aryl hydrocarbon receptor Rattus norvegicus 12-37 19497421-12 2009 Taken together, both CYP1 and AKR1C9 appear to be AhR-regulated metabolic pathways, which may contribute to formation of pro-carcinogenic PAH metabolites in liver progenitor cells. Polycyclic Aromatic Hydrocarbons 138-141 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 21-25 19497421-12 2009 Taken together, both CYP1 and AKR1C9 appear to be AhR-regulated metabolic pathways, which may contribute to formation of pro-carcinogenic PAH metabolites in liver progenitor cells. Polycyclic Aromatic Hydrocarbons 138-141 aldo-keto reductase family 1, member C14 Rattus norvegicus 30-36 19497421-12 2009 Taken together, both CYP1 and AKR1C9 appear to be AhR-regulated metabolic pathways, which may contribute to formation of pro-carcinogenic PAH metabolites in liver progenitor cells. Polycyclic Aromatic Hydrocarbons 138-141 aryl hydrocarbon receptor Rattus norvegicus 50-53 19679040-2 2009 In this study, new polycyclic aromatic hydrocarbon (PAH) conjugates were synthesized in order to more closely mimic the endogenous ligands of the cytosolic aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 19-50 aryl hydrocarbon receptor Homo sapiens 183-186 19679040-2 2009 In this study, new polycyclic aromatic hydrocarbon (PAH) conjugates were synthesized in order to more closely mimic the endogenous ligands of the cytosolic aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 52-55 aryl hydrocarbon receptor Homo sapiens 156-181 19679040-2 2009 In this study, new polycyclic aromatic hydrocarbon (PAH) conjugates were synthesized in order to more closely mimic the endogenous ligands of the cytosolic aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 52-55 aryl hydrocarbon receptor Homo sapiens 183-186 19435800-2 2009 The dioxin receptor (AhR) modulates cell plasticity and migration and its activation by occupational polycyclic aromatic hydrocarbons (PAHs) results in severe skin lesions such as contact hypersensitivity, dermatitis and chloracne. Polycyclic Aromatic Hydrocarbons 101-133 aryl-hydrocarbon receptor Mus musculus 21-24 19673251-13 2009 V-SCRT and Z-SCRT effectively reduced PAHs, hopanes and steranes, n-alkanes and acids by more than 99%, and often to levels below detection limits for both cruise and UDDS cycles. Polycyclic Aromatic Hydrocarbons 38-42 scratch family transcriptional repressor 1 Homo sapiens 2-6 19673251-13 2009 V-SCRT and Z-SCRT effectively reduced PAHs, hopanes and steranes, n-alkanes and acids by more than 99%, and often to levels below detection limits for both cruise and UDDS cycles. Polycyclic Aromatic Hydrocarbons 38-42 scratch family transcriptional repressor 1 Homo sapiens 13-17 19435800-2 2009 The dioxin receptor (AhR) modulates cell plasticity and migration and its activation by occupational polycyclic aromatic hydrocarbons (PAHs) results in severe skin lesions such as contact hypersensitivity, dermatitis and chloracne. Polycyclic Aromatic Hydrocarbons 135-139 aryl-hydrocarbon receptor Mus musculus 21-24 19430315-1 2009 OBJECTIVE: The aim of this study was to explore the relationship between UGT1A7 gene polymorphisms and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons (PAH)-exposed workers. Polycyclic Aromatic Hydrocarbons 146-178 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 73-79 19430315-1 2009 OBJECTIVE: The aim of this study was to explore the relationship between UGT1A7 gene polymorphisms and susceptibility to chromosomal damage among polycyclic aromatic hydrocarbons (PAH)-exposed workers. Polycyclic Aromatic Hydrocarbons 180-183 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 73-79 19430315-7 2009 CONCLUSION: Polymorphisms of UGT1A7 gene may alter the severity of PAH-induced chromosomal damage among the exposed workers. Polycyclic Aromatic Hydrocarbons 67-70 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 29-35 19268317-0 2009 Distributions of polycyclic aromatic hydrocarbons in the Daliao River Estuary of Liaodong Bay, Bohai Sea (China). Polycyclic Aromatic Hydrocarbons 17-49 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 101-104 19268317-2 2009 Total PAH concentrations ranged from 139.16 to 1717.87ngL(-1) in surface water, from 226.57 to 1404.85ngL(-1) dry weight in SPM, from 276.26 to 1606.89ngg(-1) dry weight in sediments, and from 10.20 to 47.27microgL(-1) in pore water. Polycyclic Aromatic Hydrocarbons 6-9 leucine rich repeat containing 4C Homo sapiens 54-60 19540355-9 2009 In PAH-exposed subjects, NPB and NBUD frequencies were influenced by gender and females have lower frequencies of NPB and NBUD. Polycyclic Aromatic Hydrocarbons 3-6 neuropeptide B Homo sapiens 25-28 19540355-9 2009 In PAH-exposed subjects, NPB and NBUD frequencies were influenced by gender and females have lower frequencies of NPB and NBUD. Polycyclic Aromatic Hydrocarbons 3-6 neuropeptide B Homo sapiens 114-117 19428948-1 2009 The aryl hydrocarbon receptor (AhR) mediates toxicity of a variety of environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. Polycyclic Aromatic Hydrocarbons 103-135 aryl-hydrocarbon receptor Mus musculus 4-29 19538838-9 2009 Genetic polymorphism of CYP1A1 gene could be a susceptible biomarker in coke oven workers which was involved in the individual susceptibility on metabolism of PAHs. Polycyclic Aromatic Hydrocarbons 159-163 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 24-30 19240225-3 2009 Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. Polycyclic Aromatic Hydrocarbons 48-80 glutathione S-transferase kappa 1 Homo sapiens 0-25 19240225-3 2009 Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. Polycyclic Aromatic Hydrocarbons 48-80 glutathione S-transferase pi 1 Homo sapiens 30-35 19240225-3 2009 Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. Polycyclic Aromatic Hydrocarbons 48-80 glutathione S-transferase kappa 1 Homo sapiens 139-164 19286049-1 2009 Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor mediating the adverse effects of dioxins and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 120-152 aryl hydrocarbon receptor Homo sapiens 0-25 19286049-1 2009 Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor mediating the adverse effects of dioxins and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 120-152 aryl hydrocarbon receptor Homo sapiens 27-30 19286049-1 2009 Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor mediating the adverse effects of dioxins and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 154-158 aryl hydrocarbon receptor Homo sapiens 0-25 19286049-1 2009 Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor mediating the adverse effects of dioxins and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 154-158 aryl hydrocarbon receptor Homo sapiens 27-30 19166822-1 2009 The aryl hydrocarbon receptor (AhR) is a basic-helix-loop-helix transcription factor that binds halogenated aromatic hydrocarbons, polycyclic aromatic hydrocarbons, and endogenous compounds. Polycyclic Aromatic Hydrocarbons 131-163 aryl-hydrocarbon receptor Mus musculus 4-29 19166822-1 2009 The aryl hydrocarbon receptor (AhR) is a basic-helix-loop-helix transcription factor that binds halogenated aromatic hydrocarbons, polycyclic aromatic hydrocarbons, and endogenous compounds. Polycyclic Aromatic Hydrocarbons 131-163 aryl-hydrocarbon receptor Mus musculus 31-34 19095305-6 2009 In mollusks, PAH concentrations were in the same order of magnitude in the whole Bohai Sea, so were DDTs, HCHs and PCBs, while the outlier maximum values of PCDDs and PCDFs occurred in Yingkou. Polycyclic Aromatic Hydrocarbons 13-16 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 87-90 19440493-1 2009 BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) may increase breast cancer risk, and the association may be modified by inherited differences in deactivation of PAH intermediates by glutathione S-transferases (GSTs). Polycyclic Aromatic Hydrocarbons 12-44 phenylalanine hydroxylase Homo sapiens 46-49 19440493-1 2009 BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) may increase breast cancer risk, and the association may be modified by inherited differences in deactivation of PAH intermediates by glutathione S-transferases (GSTs). Polycyclic Aromatic Hydrocarbons 12-44 glutathione S-transferase alpha 1 Homo sapiens 214-218 19440493-1 2009 BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) may increase breast cancer risk, and the association may be modified by inherited differences in deactivation of PAH intermediates by glutathione S-transferases (GSTs). Polycyclic Aromatic Hydrocarbons 46-50 glutathione S-transferase alpha 1 Homo sapiens 214-218 19452873-0 2009 Discovery of novel halogenated polycyclic aromatic hydrocarbons in urban particulate matters: occurrence, photostability, and AhR activity. Polycyclic Aromatic Hydrocarbons 31-63 aryl hydrocarbon receptor Homo sapiens 126-129 19233942-0 2009 Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. Polycyclic Aromatic Hydrocarbons 72-76 nfe2 like bZIP transcription factor 2a Danio rerio 26-30 19233942-2 2009 We previously reported that certain combinations of PAHs cause synergistic developmental toxicity, as observed with coexposure to the aryl hydrocarbon receptor agonist beta-naphthoflavone (BNF) and cytochrome P4501A inhibitor alpha-naphthoflavone (ANF). Polycyclic Aromatic Hydrocarbons 52-56 aryl hydrocarbon receptor 1a Danio rerio 134-159 19233942-10 2009 Collectively, these findings demonstrate that antioxidant responses are a component of PAH synergistic developmental toxicity and that NRF2 is protective against prooxidant and PAH challenges during development. Polycyclic Aromatic Hydrocarbons 177-180 nfe2 like bZIP transcription factor 2a Danio rerio 135-139 19429241-2 2009 Moreover we have suggested that in addition to its endocrine properties, adipose tissue act as a reservoir for many chemical carcinogens including Polycyclic Aromatic Hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 147-179 WD and tetratricopeptide repeats 1 Mus musculus 73-80 19429241-2 2009 Moreover we have suggested that in addition to its endocrine properties, adipose tissue act as a reservoir for many chemical carcinogens including Polycyclic Aromatic Hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 181-185 WD and tetratricopeptide repeats 1 Mus musculus 73-80 19330882-1 2009 Polycyclic aromatic hydrocarbons (PAHs) are activated by cytochrome P450 (CYP) isozymes, and a subset of the reactive metabolites generated is detoxified via conjugation with glutathione (GSH) by specific glutathione S-transferases (GSTs). Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 57-72 19330882-1 2009 Polycyclic aromatic hydrocarbons (PAHs) are activated by cytochrome P450 (CYP) isozymes, and a subset of the reactive metabolites generated is detoxified via conjugation with glutathione (GSH) by specific glutathione S-transferases (GSTs). Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 74-77 19330882-1 2009 Polycyclic aromatic hydrocarbons (PAHs) are activated by cytochrome P450 (CYP) isozymes, and a subset of the reactive metabolites generated is detoxified via conjugation with glutathione (GSH) by specific glutathione S-transferases (GSTs). Polycyclic Aromatic Hydrocarbons 0-32 glutathione S-transferase pi 1 Homo sapiens 233-237 19330882-1 2009 Polycyclic aromatic hydrocarbons (PAHs) are activated by cytochrome P450 (CYP) isozymes, and a subset of the reactive metabolites generated is detoxified via conjugation with glutathione (GSH) by specific glutathione S-transferases (GSTs). Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 57-72 19330882-1 2009 Polycyclic aromatic hydrocarbons (PAHs) are activated by cytochrome P450 (CYP) isozymes, and a subset of the reactive metabolites generated is detoxified via conjugation with glutathione (GSH) by specific glutathione S-transferases (GSTs). Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 74-77 19330882-1 2009 Polycyclic aromatic hydrocarbons (PAHs) are activated by cytochrome P450 (CYP) isozymes, and a subset of the reactive metabolites generated is detoxified via conjugation with glutathione (GSH) by specific glutathione S-transferases (GSTs). Polycyclic Aromatic Hydrocarbons 34-38 glutathione S-transferase pi 1 Homo sapiens 233-237 19269699-10 2009 Based on the ER resistant phenotype and the PAH mixture in the ER sediment, we hypothesized that the inhibition of CYP1A activity affects the teratogenicity of PAHs through a biotransformation-mediated mechanism. Polycyclic Aromatic Hydrocarbons 44-47 cytochrome P450 1A1 Fundulus heteroclitus 115-120 19269699-10 2009 Based on the ER resistant phenotype and the PAH mixture in the ER sediment, we hypothesized that the inhibition of CYP1A activity affects the teratogenicity of PAHs through a biotransformation-mediated mechanism. Polycyclic Aromatic Hydrocarbons 160-164 cytochrome P450 1A1 Fundulus heteroclitus 115-120 19326105-4 2009 The method was applied to nitrosamines, alkylbenzenes, phenols, benzene derivatives, polycyclic aromatic hydrocarbons and beta-blockers, among other compounds, chromatographed in a cyano and several C18 columns. Polycyclic Aromatic Hydrocarbons 85-117 Bardet-Biedl syndrome 9 Homo sapiens 199-202 19526463-1 2009 Arsenite, an environmental cocontaminant of polycyclic aromatic hydrocarbons (PAHs), diminishes the PAH-mediated upregulation of human CYP1A1, the enzyme that bioactivates PAHs to carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 44-76 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 19526463-1 2009 Arsenite, an environmental cocontaminant of polycyclic aromatic hydrocarbons (PAHs), diminishes the PAH-mediated upregulation of human CYP1A1, the enzyme that bioactivates PAHs to carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 78-82 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 19526463-1 2009 Arsenite, an environmental cocontaminant of polycyclic aromatic hydrocarbons (PAHs), diminishes the PAH-mediated upregulation of human CYP1A1, the enzyme that bioactivates PAHs to carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 78-81 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 19526463-1 2009 Arsenite, an environmental cocontaminant of polycyclic aromatic hydrocarbons (PAHs), diminishes the PAH-mediated upregulation of human CYP1A1, the enzyme that bioactivates PAHs to carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 172-176 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 19526463-5 2009 Arsenite decreased the induction of CYP1A1 by a PAH, benzo[k]fluoranthene (BKF), by 50%; and transfection of HepG2 cells with siRNA targeting the human HO-1 gene, reduced the arsenite downregulation of BKF-induced CYP1A1 from 54% to 27%, relative to untransfected cells. Polycyclic Aromatic Hydrocarbons 48-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 19526463-5 2009 Arsenite decreased the induction of CYP1A1 by a PAH, benzo[k]fluoranthene (BKF), by 50%; and transfection of HepG2 cells with siRNA targeting the human HO-1 gene, reduced the arsenite downregulation of BKF-induced CYP1A1 from 54% to 27%, relative to untransfected cells. Polycyclic Aromatic Hydrocarbons 48-51 heme oxygenase 1 Homo sapiens 152-156 19087973-0 2009 Induction of proapoptotic gene expression and recruitment of p53 herald ovarian follicle loss caused by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 104-136 transformation related protein 53, pseudogene Mus musculus 61-64 19087973-1 2009 Activation of the aryl hydrocarbon receptor (AHR) by polycyclic aromatic hydrocarbons (PAH), a ubiquitous class of environmental and occupational biohazards, accelerates germ cell depletion in female mice during prenatal and postnatal life. Polycyclic Aromatic Hydrocarbons 53-85 aryl-hydrocarbon receptor Mus musculus 18-43 19087973-1 2009 Activation of the aryl hydrocarbon receptor (AHR) by polycyclic aromatic hydrocarbons (PAH), a ubiquitous class of environmental and occupational biohazards, accelerates germ cell depletion in female mice during prenatal and postnatal life. Polycyclic Aromatic Hydrocarbons 53-85 aryl-hydrocarbon receptor Mus musculus 45-48 19087973-1 2009 Activation of the aryl hydrocarbon receptor (AHR) by polycyclic aromatic hydrocarbons (PAH), a ubiquitous class of environmental and occupational biohazards, accelerates germ cell depletion in female mice during prenatal and postnatal life. Polycyclic Aromatic Hydrocarbons 87-90 aryl-hydrocarbon receptor Mus musculus 18-43 19087973-1 2009 Activation of the aryl hydrocarbon receptor (AHR) by polycyclic aromatic hydrocarbons (PAH), a ubiquitous class of environmental and occupational biohazards, accelerates germ cell depletion in female mice during prenatal and postnatal life. Polycyclic Aromatic Hydrocarbons 87-90 aryl-hydrocarbon receptor Mus musculus 45-48 19087973-2 2009 Like AHR, BAX is also functionally required for PAH to kill oocytes. Polycyclic Aromatic Hydrocarbons 48-51 aryl-hydrocarbon receptor Mus musculus 5-8 19087973-2 2009 Like AHR, BAX is also functionally required for PAH to kill oocytes. Polycyclic Aromatic Hydrocarbons 48-51 BCL2-associated X protein Mus musculus 10-13 19087973-3 2009 Here, we show that PAH upregulates ovarian expression of not just Bax but a large cassette of proapoptotic genes that function at multiple steps of the cell death signaling pathway. Polycyclic Aromatic Hydrocarbons 19-22 BCL2-associated X protein Mus musculus 66-69 19087973-4 2009 We further show that ovarian expression of p53 and several proapoptotic genes that are known transcriptional targets of p53 are increased by PAH treatment, and that mice lacking functional p53 are resistant to the ovotoxic effects of in vivo PAH exposure. Polycyclic Aromatic Hydrocarbons 141-144 transformation related protein 53, pseudogene Mus musculus 43-46 19087973-4 2009 We further show that ovarian expression of p53 and several proapoptotic genes that are known transcriptional targets of p53 are increased by PAH treatment, and that mice lacking functional p53 are resistant to the ovotoxic effects of in vivo PAH exposure. Polycyclic Aromatic Hydrocarbons 141-144 transformation related protein 53, pseudogene Mus musculus 120-123 19087973-4 2009 We further show that ovarian expression of p53 and several proapoptotic genes that are known transcriptional targets of p53 are increased by PAH treatment, and that mice lacking functional p53 are resistant to the ovotoxic effects of in vivo PAH exposure. Polycyclic Aromatic Hydrocarbons 141-144 transformation related protein 53, pseudogene Mus musculus 120-123 19087973-4 2009 We further show that ovarian expression of p53 and several proapoptotic genes that are known transcriptional targets of p53 are increased by PAH treatment, and that mice lacking functional p53 are resistant to the ovotoxic effects of in vivo PAH exposure. Polycyclic Aromatic Hydrocarbons 242-245 transformation related protein 53, pseudogene Mus musculus 43-46 19087973-4 2009 We further show that ovarian expression of p53 and several proapoptotic genes that are known transcriptional targets of p53 are increased by PAH treatment, and that mice lacking functional p53 are resistant to the ovotoxic effects of in vivo PAH exposure. Polycyclic Aromatic Hydrocarbons 242-245 transformation related protein 53, pseudogene Mus musculus 120-123 19087973-4 2009 We further show that ovarian expression of p53 and several proapoptotic genes that are known transcriptional targets of p53 are increased by PAH treatment, and that mice lacking functional p53 are resistant to the ovotoxic effects of in vivo PAH exposure. Polycyclic Aromatic Hydrocarbons 242-245 transformation related protein 53, pseudogene Mus musculus 120-123 19087973-5 2009 This study provides further mechanistic insights into how PAH accelerate oocyte depletion in females and adds p53 to the list of genes whose functional importance to PAH-induced ovotoxicity has been demonstrated by gene knockout technology. Polycyclic Aromatic Hydrocarbons 166-169 transformation related protein 53, pseudogene Mus musculus 110-113 19193393-1 2009 The aim was to explore the relationship between the ataxia-telangiectasia mutated (ATM) gene polymorphisms and susceptibility to cytokinesis-block micronucleus among workers exposed to polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 185-217 ATM serine/threonine kinase Homo sapiens 52-81 19193393-1 2009 The aim was to explore the relationship between the ataxia-telangiectasia mutated (ATM) gene polymorphisms and susceptibility to cytokinesis-block micronucleus among workers exposed to polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 185-217 ATM serine/threonine kinase Homo sapiens 83-86 19193393-1 2009 The aim was to explore the relationship between the ataxia-telangiectasia mutated (ATM) gene polymorphisms and susceptibility to cytokinesis-block micronucleus among workers exposed to polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 219-222 ATM serine/threonine kinase Homo sapiens 52-81 19193393-1 2009 The aim was to explore the relationship between the ataxia-telangiectasia mutated (ATM) gene polymorphisms and susceptibility to cytokinesis-block micronucleus among workers exposed to polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 219-222 ATM serine/threonine kinase Homo sapiens 83-86 19193393-10 2009 In conclusion, it is suggested that the polymorphisms of ATM were associated with the CBMN frequencies among PAH-exposed workers. Polycyclic Aromatic Hydrocarbons 109-112 ATM serine/threonine kinase Homo sapiens 57-60 19158084-1 2009 The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix family of transcription factors, binds with high affinity to polycyclic aromatic hydrocarbons (PAH) and the environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). Polycyclic Aromatic Hydrocarbons 154-186 aryl hydrocarbon receptor Homo sapiens 4-29 19158084-1 2009 The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix family of transcription factors, binds with high affinity to polycyclic aromatic hydrocarbons (PAH) and the environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). Polycyclic Aromatic Hydrocarbons 154-186 aryl hydrocarbon receptor Homo sapiens 31-34 19158084-1 2009 The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix family of transcription factors, binds with high affinity to polycyclic aromatic hydrocarbons (PAH) and the environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). Polycyclic Aromatic Hydrocarbons 188-191 aryl hydrocarbon receptor Homo sapiens 4-29 19158084-1 2009 The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix family of transcription factors, binds with high affinity to polycyclic aromatic hydrocarbons (PAH) and the environmental toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin). Polycyclic Aromatic Hydrocarbons 188-191 aryl hydrocarbon receptor Homo sapiens 31-34 19158084-2 2009 Most of the biochemical, biological, and toxicological responses caused by exposure to PAHs and polychlorinated dioxins are mediated, at least in part, by the AhR. Polycyclic Aromatic Hydrocarbons 87-91 aryl hydrocarbon receptor Homo sapiens 159-162 19158084-5 2009 Trichostatin A and suberoylanilide hydroxamic acid, two broad spectrum HDAC inhibitors, blocked PAH and dioxin-mediated induction of CYP1A1 and CYP1B1 in cell lines derived from the human aerodigestive tract. Polycyclic Aromatic Hydrocarbons 96-99 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 144-150 19227980-1 2009 In this work, we demonstrate the utility of ultra performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry (UPLC-APPI-MS/MS) for high-sensitivity and high-throughput analysis of United States Environmental Protection Agency (U.S. EPA) 16 priority pollutants polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 297-329 amyloid beta precursor protein Homo sapiens 152-156 19227980-1 2009 In this work, we demonstrate the utility of ultra performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry (UPLC-APPI-MS/MS) for high-sensitivity and high-throughput analysis of United States Environmental Protection Agency (U.S. EPA) 16 priority pollutants polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 331-335 amyloid beta precursor protein Homo sapiens 152-156 19368229-0 2009 Relative potencies of individual chlorinated and brominated polycyclic aromatic hydrocarbons for induction of aryl hydrocarbon receptor-mediated responses. Polycyclic Aromatic Hydrocarbons 60-92 spineless Drosophila melanogaster 110-135 19162045-2 2009 Other studies have demonstrated the oxidative activation of polycyclic aromatic hydrocarbon (PAH) procarcinogens by AKR1C3 in cell-free systems. Polycyclic Aromatic Hydrocarbons 60-91 aldo-keto reductase family 1 member C3 Homo sapiens 116-122 19162045-2 2009 Other studies have demonstrated the oxidative activation of polycyclic aromatic hydrocarbon (PAH) procarcinogens by AKR1C3 in cell-free systems. Polycyclic Aromatic Hydrocarbons 93-96 aldo-keto reductase family 1 member C3 Homo sapiens 116-122 19428948-1 2009 The aryl hydrocarbon receptor (AhR) mediates toxicity of a variety of environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. Polycyclic Aromatic Hydrocarbons 103-135 aryl-hydrocarbon receptor Mus musculus 31-34 19428948-1 2009 The aryl hydrocarbon receptor (AhR) mediates toxicity of a variety of environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. Polycyclic Aromatic Hydrocarbons 137-141 aryl-hydrocarbon receptor Mus musculus 4-29 19428948-1 2009 The aryl hydrocarbon receptor (AhR) mediates toxicity of a variety of environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) and dioxins. Polycyclic Aromatic Hydrocarbons 137-141 aryl-hydrocarbon receptor Mus musculus 31-34 19270430-1 2009 Polycyclic aromatic hydrocarbons (PAHs) and dioxins are ubiquitous environmental pollutants and activate the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 109-134 19270430-1 2009 Polycyclic aromatic hydrocarbons (PAHs) and dioxins are ubiquitous environmental pollutants and activate the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 136-139 19270430-1 2009 Polycyclic aromatic hydrocarbons (PAHs) and dioxins are ubiquitous environmental pollutants and activate the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 109-134 19270430-1 2009 Polycyclic aromatic hydrocarbons (PAHs) and dioxins are ubiquitous environmental pollutants and activate the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 136-139 19250544-4 2009 P-glycoprotein is present in the intestinal mucosal lining and restricts absorption of certain carcinogens, among these polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 120-152 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 18817753-1 2009 Exposure to toxic polycyclic aromatic hydrocarbons raises a number of toxic and carcinogenic responses in experimental animals and humans mediated for the most part by the aryl hydrocarbon -- or dioxin -- receptor (AHR). Polycyclic Aromatic Hydrocarbons 18-50 aryl hydrocarbon receptor Homo sapiens 215-218 19209607-2 2009 Previous studies using zebrafish demonstrated that crude oil exposure causes cardiogenic edema, and that the most abundant polycyclic aromatic hydrocarbons (PAHs) in weathered crude oils (tricyclic fluorenes, dibenzothiophenes, and phenanthrenes) are cardiotoxic, causing arrhythmia through a pathway that does not require activation of the aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 157-161 aryl hydrocarbon receptor 1a Danio rerio 341-366 18560987-9 2009 The BaP and relative BaP amount calculated from the measurements suggested that photo-oxidation may also be responsible for the variation in PAH concentrations during winter and summer. Polycyclic Aromatic Hydrocarbons 141-144 prohibitin 2 Homo sapiens 21-24 18757099-9 2009 Based on the mass balance analysis, PCDD/Fs, PCBs and PAHs could account for the observed AhR responses in vitro elicited by soil extracts, though their respective contributions varied depending on sample location. Polycyclic Aromatic Hydrocarbons 54-58 aryl hydrocarbon receptor Rattus norvegicus 90-93 19165387-5 2009 On the other hand, a pathway-specific gene expression screen indicated that, for particles rich in polycyclic aromatic hydrocarbon (PAHs), cytochrome P450 1A1 (CYP1A1) enzyme-mediated biotransformation of bio-available organics may generate oxidative stress and thus enhance the in vivo inflammatory response. Polycyclic Aromatic Hydrocarbons 99-130 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 139-158 19165387-5 2009 On the other hand, a pathway-specific gene expression screen indicated that, for particles rich in polycyclic aromatic hydrocarbon (PAHs), cytochrome P450 1A1 (CYP1A1) enzyme-mediated biotransformation of bio-available organics may generate oxidative stress and thus enhance the in vivo inflammatory response. Polycyclic Aromatic Hydrocarbons 99-130 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 160-166 19165387-5 2009 On the other hand, a pathway-specific gene expression screen indicated that, for particles rich in polycyclic aromatic hydrocarbon (PAHs), cytochrome P450 1A1 (CYP1A1) enzyme-mediated biotransformation of bio-available organics may generate oxidative stress and thus enhance the in vivo inflammatory response. Polycyclic Aromatic Hydrocarbons 132-136 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 139-158 19165387-5 2009 On the other hand, a pathway-specific gene expression screen indicated that, for particles rich in polycyclic aromatic hydrocarbon (PAHs), cytochrome P450 1A1 (CYP1A1) enzyme-mediated biotransformation of bio-available organics may generate oxidative stress and thus enhance the in vivo inflammatory response. Polycyclic Aromatic Hydrocarbons 132-136 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 160-166 19157061-3 2009 The focus of this present review lies on the influence of the molecular structure of two well-investigated chemical carcinogens from the group of polycyclic aromatic hydrocarbons (PAHs), benzo[a]pyrene (BP) and dibenzo[a,l]pyrene (DBP). Polycyclic Aromatic Hydrocarbons 146-178 D-box binding PAR bZIP transcription factor Homo sapiens 231-234 19157061-3 2009 The focus of this present review lies on the influence of the molecular structure of two well-investigated chemical carcinogens from the group of polycyclic aromatic hydrocarbons (PAHs), benzo[a]pyrene (BP) and dibenzo[a,l]pyrene (DBP). Polycyclic Aromatic Hydrocarbons 180-184 D-box binding PAR bZIP transcription factor Homo sapiens 231-234 19346634-1 2009 BACKGROUND: The Cytochrome P-4501A1 (CYP1A1) gene, located on chromosome 15q, is involved in the metabolism of carcinogens mainly polycyclic aromatic hydrocarbons as well as estrogen. Polycyclic Aromatic Hydrocarbons 130-162 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-35 19346634-1 2009 BACKGROUND: The Cytochrome P-4501A1 (CYP1A1) gene, located on chromosome 15q, is involved in the metabolism of carcinogens mainly polycyclic aromatic hydrocarbons as well as estrogen. Polycyclic Aromatic Hydrocarbons 130-162 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 37-43 19202560-1 2009 CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. Polycyclic Aromatic Hydrocarbons 37-69 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 19202560-1 2009 CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. Polycyclic Aromatic Hydrocarbons 37-69 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 11-17 19202560-1 2009 CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. Polycyclic Aromatic Hydrocarbons 71-75 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 19202560-1 2009 CYP1A1 and CYP1A2 enzymes metabolize polycyclic aromatic hydrocarbons (PAHs) to the reactive oxyderivatives. Polycyclic Aromatic Hydrocarbons 71-75 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 11-17 18818557-1 2009 BACKGROUND AND OBJECTIVE: Most of the carcinogenic effects of polycyclic aromatic hydrocarbons present in tobacco smoke are mediated by the aryl hydrocarbon receptor (AHR), a ligand-dependent transcription factor that regulates tobacco-induced expression of carcinogen metabolic enzymes. Polycyclic Aromatic Hydrocarbons 62-94 aryl hydrocarbon receptor Homo sapiens 140-165 18818557-1 2009 BACKGROUND AND OBJECTIVE: Most of the carcinogenic effects of polycyclic aromatic hydrocarbons present in tobacco smoke are mediated by the aryl hydrocarbon receptor (AHR), a ligand-dependent transcription factor that regulates tobacco-induced expression of carcinogen metabolic enzymes. Polycyclic Aromatic Hydrocarbons 62-94 aryl hydrocarbon receptor Homo sapiens 167-170 18848954-6 2008 We developed a pregnant mouse model in which exposure to the polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), during late gestation, produces an aggressive T-cell lymphoma in offspring between 3 and 6 months of age. Polycyclic Aromatic Hydrocarbons 61-92 D site albumin promoter binding protein Mus musculus 120-123 18848954-6 2008 We developed a pregnant mouse model in which exposure to the polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), during late gestation, produces an aggressive T-cell lymphoma in offspring between 3 and 6 months of age. Polycyclic Aromatic Hydrocarbons 94-97 D site albumin promoter binding protein Mus musculus 120-123 18848954-12 2008 Our results demonstrate that short exposure to DBP during late gestation presents a greater risk to offspring than exposure to this very hydrophobic PAH following 3 weeks of nursing. Polycyclic Aromatic Hydrocarbons 149-152 D site albumin promoter binding protein Mus musculus 47-50 19140732-1 2009 MP2 calculations of the stacking energy are reported for the dimers of a set of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 80-112 tryptase pseudogene 1 Homo sapiens 0-3 18952161-3 2009 In human AM in mono- and coculture, and in L132 cells in monoculture, VOC and/or PAH-coated onto PM induced the gene expression of CYP1A1, CYP2E1, NQO1, GST-pi1, and/or GST-mu3. Polycyclic Aromatic Hydrocarbons 81-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 131-137 18952161-3 2009 In human AM in mono- and coculture, and in L132 cells in monoculture, VOC and/or PAH-coated onto PM induced the gene expression of CYP1A1, CYP2E1, NQO1, GST-pi1, and/or GST-mu3. Polycyclic Aromatic Hydrocarbons 81-84 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 139-145 18952161-3 2009 In human AM in mono- and coculture, and in L132 cells in monoculture, VOC and/or PAH-coated onto PM induced the gene expression of CYP1A1, CYP2E1, NQO1, GST-pi1, and/or GST-mu3. Polycyclic Aromatic Hydrocarbons 81-84 NAD(P)H quinone dehydrogenase 1 Homo sapiens 147-151 19053321-1 2009 Dibenzo[a,l]pyrene (DBP) is the most potent tumor initiating polycyclic aromatic hydrocarbon tested to date in rodent tumor models. Polycyclic Aromatic Hydrocarbons 61-92 D-box binding PAR bZIP transcription factor Homo sapiens 20-23 20419055-2 2009 Most of the toxic effects of halogenated and non-halogenated polycyclic aromatic hydrocarbons (HAHs and PAHs respectively) are mediated by the AHR. Polycyclic Aromatic Hydrocarbons 61-93 aryl-hydrocarbon receptor Mus musculus 143-146 20419055-2 2009 Most of the toxic effects of halogenated and non-halogenated polycyclic aromatic hydrocarbons (HAHs and PAHs respectively) are mediated by the AHR. Polycyclic Aromatic Hydrocarbons 104-108 aryl-hydrocarbon receptor Mus musculus 143-146 19221603-0 2009 Relation of DNA methylation of 5"-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. Polycyclic Aromatic Hydrocarbons 93-125 acyl-CoA synthetase long chain family member 3 Homo sapiens 48-53 19221603-10 2009 Methylation of the ACSL3 5"-CGI was found to be significantly associated with maternal airborne PAH exposure exceeding 2.41 ng/m(3) (OR = 13.8; p<0.001; sensitivity = 75%; specificity = 82%) and with a parental report of asthma symptoms in children prior to age 5 (OR = 3.9; p<0.05). Polycyclic Aromatic Hydrocarbons 96-99 acyl-CoA synthetase long chain family member 3 Homo sapiens 19-24 19029401-3 2008 We investigated whether higher CYP2A6 activity results in the smoker extracting more nicotine (adjusting for cigarettes per day) and being exposed to higher levels of tobacco-specific nitrosamine [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)] and pyrene, a representative polycyclic aromatic hydrocarbon. Polycyclic Aromatic Hydrocarbons 280-311 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 31-37 19548353-0 2008 Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1B1 in inhibiting catalytic activity. Polycyclic Aromatic Hydrocarbons 15-47 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 59-78 19548353-1 2008 Eleven polycyclic aromatic hydrocarbons (PAHs) and 14 acetylenic PAHs and biphenyls were used to analyze interactions with cytochrome P450 (P450) 1B1 in inhibiting catalytic activity, using 7-ethoxyresorufin O-deethylation (EROD) as a model reaction. Polycyclic Aromatic Hydrocarbons 7-39 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 123-149 19548353-1 2008 Eleven polycyclic aromatic hydrocarbons (PAHs) and 14 acetylenic PAHs and biphenyls were used to analyze interactions with cytochrome P450 (P450) 1B1 in inhibiting catalytic activity, using 7-ethoxyresorufin O-deethylation (EROD) as a model reaction. Polycyclic Aromatic Hydrocarbons 41-45 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 123-149 19548353-1 2008 Eleven polycyclic aromatic hydrocarbons (PAHs) and 14 acetylenic PAHs and biphenyls were used to analyze interactions with cytochrome P450 (P450) 1B1 in inhibiting catalytic activity, using 7-ethoxyresorufin O-deethylation (EROD) as a model reaction. Polycyclic Aromatic Hydrocarbons 65-69 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 123-149 19548353-8 2008 Molecular docking of P450 1B1, based on P450 1A2 crystal structure, suggested that there are clear differences in the interaction of PAH inhibitors with P450 1B1 and 1A2 and that these differences may explain why PAH inhibitors inhibit P450 1 enzymes by different mechanisms. Polycyclic Aromatic Hydrocarbons 133-136 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-29 19548353-8 2008 Molecular docking of P450 1B1, based on P450 1A2 crystal structure, suggested that there are clear differences in the interaction of PAH inhibitors with P450 1B1 and 1A2 and that these differences may explain why PAH inhibitors inhibit P450 1 enzymes by different mechanisms. Polycyclic Aromatic Hydrocarbons 133-136 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 153-169 19548353-8 2008 Molecular docking of P450 1B1, based on P450 1A2 crystal structure, suggested that there are clear differences in the interaction of PAH inhibitors with P450 1B1 and 1A2 and that these differences may explain why PAH inhibitors inhibit P450 1 enzymes by different mechanisms. Polycyclic Aromatic Hydrocarbons 213-216 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-29 19548353-8 2008 Molecular docking of P450 1B1, based on P450 1A2 crystal structure, suggested that there are clear differences in the interaction of PAH inhibitors with P450 1B1 and 1A2 and that these differences may explain why PAH inhibitors inhibit P450 1 enzymes by different mechanisms. Polycyclic Aromatic Hydrocarbons 213-216 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 153-169 19548353-9 2008 The results suggest that P450 1B1 interacts with synthetic polycyclic aromatic acetylenes and PAHs in different ways, depending on the chemicals, and that these differences in interactions may explain how these chemicals inhibit P450 activities by different mechanisms. Polycyclic Aromatic Hydrocarbons 94-98 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 25-33 19209607-2 2009 Previous studies using zebrafish demonstrated that crude oil exposure causes cardiogenic edema, and that the most abundant polycyclic aromatic hydrocarbons (PAHs) in weathered crude oils (tricyclic fluorenes, dibenzothiophenes, and phenanthrenes) are cardiotoxic, causing arrhythmia through a pathway that does not require activation of the aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 157-161 aryl hydrocarbon receptor 1a Danio rerio 368-371 18626632-11 2008 Duodenal microsomes of minipigs orally exposed to polycyclic aromatic hydrocarbons show a clear CYP1A1 signal. Polycyclic Aromatic Hydrocarbons 50-82 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 96-102 18985206-0 2008 Diborylenetetraaminoperylenes (DIBOTAP): a new class of highly fluorescent functional polycyclic aromatic hydrocarbons with N-B-N units. Polycyclic Aromatic Hydrocarbons 86-118 nibrin Homo sapiens 124-129 18704375-6 2008 The consequences are very different from those of AHR nuclear translocation mediated by its classic ligands (such as dioxin and many polycyclic aromatic hydrocarbons) and may represent the long-sought physiological function of the AHR. Polycyclic Aromatic Hydrocarbons 133-165 aryl hydrocarbon receptor Homo sapiens 50-53 18704375-6 2008 The consequences are very different from those of AHR nuclear translocation mediated by its classic ligands (such as dioxin and many polycyclic aromatic hydrocarbons) and may represent the long-sought physiological function of the AHR. Polycyclic Aromatic Hydrocarbons 133-165 aryl hydrocarbon receptor Homo sapiens 231-234 18797853-4 2008 Our studies were carried out with metabolically competent primary porcine urinary bladder epithelial cells (PUBECs) and the human urothelial cell line 5637 for which we have previously demonstrated CYP1A1 mRNA induction by the polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (B[a]P) applying real-time RT-PCR. Polycyclic Aromatic Hydrocarbons 227-260 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 198-204 18797853-4 2008 Our studies were carried out with metabolically competent primary porcine urinary bladder epithelial cells (PUBECs) and the human urothelial cell line 5637 for which we have previously demonstrated CYP1A1 mRNA induction by the polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (B[a]P) applying real-time RT-PCR. Polycyclic Aromatic Hydrocarbons 260-264 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 198-204 19138996-1 2008 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (HSP90), plays a significant role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 116-147 heat shock protein 90 alpha family class A member 1 Homo sapiens 80-85 19138996-1 2008 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (HSP90), plays a significant role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 116-147 aryl hydrocarbon receptor Homo sapiens 4-29 18950284-1 2008 BACKGROUND: Halogenated aromatic hydrocarbons including dioxins and non-halogenated polycyclic aromatic hydrocarbons are ligands of an aryl hydrocarbon receptor (AhR) and stimulate its transformation. Polycyclic Aromatic Hydrocarbons 84-116 aryl hydrocarbon receptor Homo sapiens 135-160 18950284-1 2008 BACKGROUND: Halogenated aromatic hydrocarbons including dioxins and non-halogenated polycyclic aromatic hydrocarbons are ligands of an aryl hydrocarbon receptor (AhR) and stimulate its transformation. Polycyclic Aromatic Hydrocarbons 84-116 aryl hydrocarbon receptor Homo sapiens 162-165 18796340-0 2008 Poly-aromatic hydrocarbon (PAH) inputs from the Rhone River to the Mediterranean Sea in relation with the hydrological cycle: impact of floods. Polycyclic Aromatic Hydrocarbons 27-30 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 81-84 18353549-5 2008 PAH homologue distributions of the three selected sintering process areas were significantly different from that of the outdoor environment suggesting that PAHs found in the sintering workplace atmospheres were mainly contributed by process fugitives. Polycyclic Aromatic Hydrocarbons 156-160 phenylalanine hydroxylase Homo sapiens 0-3 19138996-1 2008 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (HSP90), plays a significant role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 116-147 aryl hydrocarbon receptor Homo sapiens 31-34 19138996-1 2008 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (HSP90), plays a significant role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 149-152 aryl hydrocarbon receptor Homo sapiens 4-29 19138996-1 2008 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (HSP90), plays a significant role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 116-147 heat shock protein 90 alpha family class A member 1 Homo sapiens 57-78 19138996-1 2008 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (HSP90), plays a significant role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 149-152 aryl hydrocarbon receptor Homo sapiens 31-34 19138996-1 2008 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (HSP90), plays a significant role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 149-152 heat shock protein 90 alpha family class A member 1 Homo sapiens 57-78 19138996-1 2008 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (HSP90), plays a significant role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 149-152 heat shock protein 90 alpha family class A member 1 Homo sapiens 80-85 19138996-2 2008 Tobacco smoke, a source of PAHs, activates the AhR, leading to enhanced transcription of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 27-31 aryl hydrocarbon receptor Homo sapiens 47-50 19138996-2 2008 Tobacco smoke, a source of PAHs, activates the AhR, leading to enhanced transcription of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 27-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 89-95 19138996-2 2008 Tobacco smoke, a source of PAHs, activates the AhR, leading to enhanced transcription of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 27-31 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 100-106 19138996-2 2008 Tobacco smoke, a source of PAHs, activates the AhR, leading to enhanced transcription of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 143-147 aryl hydrocarbon receptor Homo sapiens 47-50 19138996-2 2008 Tobacco smoke, a source of PAHs, activates the AhR, leading to enhanced transcription of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 143-147 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 89-95 19138996-2 2008 Tobacco smoke, a source of PAHs, activates the AhR, leading to enhanced transcription of CYP1A1 and CYP1B1, which encode proteins that convert PAHs to genotoxic metabolites. Polycyclic Aromatic Hydrocarbons 143-147 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 100-106 19138996-3 2008 The main objectives of this study were to determine whether HSP90 inhibitors suppress PAH-mediated induction of CYP1A1 and CYP1B1 or block benzo(a)pyrene [B(a)P]-induced formation of DNA adducts. Polycyclic Aromatic Hydrocarbons 86-89 heat shock protein 90 alpha family class A member 1 Homo sapiens 60-65 19138996-3 2008 The main objectives of this study were to determine whether HSP90 inhibitors suppress PAH-mediated induction of CYP1A1 and CYP1B1 or block benzo(a)pyrene [B(a)P]-induced formation of DNA adducts. Polycyclic Aromatic Hydrocarbons 86-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 112-118 19138996-3 2008 The main objectives of this study were to determine whether HSP90 inhibitors suppress PAH-mediated induction of CYP1A1 and CYP1B1 or block benzo(a)pyrene [B(a)P]-induced formation of DNA adducts. Polycyclic Aromatic Hydrocarbons 86-89 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 123-129 19138996-5 2008 Inhibitors of HSP90 [17-allylamino-17-demethoxygeldanamycin (17-AAG); celastrol] suppressed these inductive effects of PAHs. Polycyclic Aromatic Hydrocarbons 119-123 heat shock protein 90 alpha family class A member 1 Homo sapiens 14-19 18834363-1 2008 AIM: CYP1A2, a constitutive enzyme expressed in the liver, is among the phase I enzymes responsible for polycyclic aromatic hydrocarbons metabolism. Polycyclic Aromatic Hydrocarbons 104-136 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 5-11 22063352-5 2008 BaP comprises in general 4.6% of the total sum of the 16 EU priority PAHs and 15.2% of the total sum of the 12 IARC PAH compounds. Polycyclic Aromatic Hydrocarbons 69-72 prohibitin 2 Homo sapiens 0-3 18794127-1 2008 Cytochrome P450 1B1 (Cyp1b1) metabolism contributes to physiologic functions during embryogenesis but also to carcinogenic activation of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 137-169 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 0-19 18794127-1 2008 Cytochrome P450 1B1 (Cyp1b1) metabolism contributes to physiologic functions during embryogenesis but also to carcinogenic activation of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 137-169 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 21-27 18794127-1 2008 Cytochrome P450 1B1 (Cyp1b1) metabolism contributes to physiologic functions during embryogenesis but also to carcinogenic activation of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 171-174 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 0-19 18794127-1 2008 Cytochrome P450 1B1 (Cyp1b1) metabolism contributes to physiologic functions during embryogenesis but also to carcinogenic activation of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 171-174 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 21-27 18794127-14 2008 Tumorigenesis may, therefore, depend on activation of PAH by Cyp1b1 and on offsetting suppression by Cyp1b1 of endogenous tumor-enhancing substrates. Polycyclic Aromatic Hydrocarbons 54-57 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 61-67 18270801-2 2008 According to the concentrations in the core three groups of PAHs may be distinguished: (1) relatively stable concentrations of PAHs within the whole studied time interval; (2) very low concentrations in sediments accumulated before intensive anthropogenic impact (from 19th century up to the 1920s) following a slight increase and (3) an overall increase in PAH concentrations since the 1920s up to the present. Polycyclic Aromatic Hydrocarbons 127-131 phenylalanine hydroxylase Homo sapiens 60-63 18367723-7 2008 Inhalation of PAH-rich, petrochemical combustion-derived nanoparticles causes airway inflammation and induces expression of AhR-associated and oxidative stress response genes, as seen in vitro, plus pro-inflammatory genes. Polycyclic Aromatic Hydrocarbons 14-17 aryl-hydrocarbon receptor Mus musculus 124-127 17651397-1 2008 Cytochrome P4501A1 (CYP1A1) is a key enzyme in phase I bioactivation of polycyclic aromatic hydrocarbons (PAHs), which have potential reproductive toxicity. Polycyclic Aromatic Hydrocarbons 72-104 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 17651397-1 2008 Cytochrome P4501A1 (CYP1A1) is a key enzyme in phase I bioactivation of polycyclic aromatic hydrocarbons (PAHs), which have potential reproductive toxicity. Polycyclic Aromatic Hydrocarbons 72-104 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 17651397-1 2008 Cytochrome P4501A1 (CYP1A1) is a key enzyme in phase I bioactivation of polycyclic aromatic hydrocarbons (PAHs), which have potential reproductive toxicity. Polycyclic Aromatic Hydrocarbons 106-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 17651397-1 2008 Cytochrome P4501A1 (CYP1A1) is a key enzyme in phase I bioactivation of polycyclic aromatic hydrocarbons (PAHs), which have potential reproductive toxicity. Polycyclic Aromatic Hydrocarbons 106-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 18634860-2 2008 Many PAHs are aryl hydrocarbon receptor (AhR) ligands and several recent studies have suggested that PAHs or their metabolites may activate estrogen receptors (ER). Polycyclic Aromatic Hydrocarbons 5-9 aryl hydrocarbon receptor Rattus norvegicus 14-39 18634860-2 2008 Many PAHs are aryl hydrocarbon receptor (AhR) ligands and several recent studies have suggested that PAHs or their metabolites may activate estrogen receptors (ER). Polycyclic Aromatic Hydrocarbons 5-9 aryl hydrocarbon receptor Rattus norvegicus 41-44 18634860-9 2008 With the exception of Fla, all three remaining compounds increased CYP1-dependent monooxygenation activities in liver at the doses used, suggesting that the potential tissue-specific antiestrogenic effects of PAHs mediated by metabolization of 17beta-estradiol also cannot be excluded. Polycyclic Aromatic Hydrocarbons 209-213 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 67-71 18559983-0 2008 Fetal growth restriction triggered by polycyclic aromatic hydrocarbons is associated with altered placental vasculature and AhR-dependent changes in cell death. Polycyclic Aromatic Hydrocarbons 38-70 aryl hydrocarbon receptor Homo sapiens 124-127 18559983-8 2008 AhR-deficient fetuses were rescued from PAH-induced growth restriction and exhibited no changes in the labyrinthine cell death rate. Polycyclic Aromatic Hydrocarbons 40-43 aryl hydrocarbon receptor Homo sapiens 0-3 18839584-8 2008 The concentration of BaP, a strong carcinogenic PAH, was found in sludge with 0-2.20 mg x kg(-1) and the average of 0.15 mg x kg(-1), which was much less than 3.0 mg x kg(-1) of the control standard of sludge land application. Polycyclic Aromatic Hydrocarbons 48-51 prohibitin 2 Homo sapiens 21-24 18635525-1 2008 Our laboratory recently developed a mouse model of transplacental induction of lymphoma, lung and liver cancer by the polycyclic aromatic hydrocarbon, dibenzo[a,l]pyrene (DBP). Polycyclic Aromatic Hydrocarbons 118-149 D site albumin promoter binding protein Mus musculus 171-174 19317600-1 2008 Cytochrome 1A1 (CYP1A1), glutathione transferase M1 (GSTM1), and glutathione transferase T1 (GSTT1) catalyze the bioactivation and detoxification of a wide variety of xenobiotic compounds that are mutagenic and/or carcinogenic (e.g., polycyclic aromatic hydrocarbons). Polycyclic Aromatic Hydrocarbons 234-266 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-14 19317600-1 2008 Cytochrome 1A1 (CYP1A1), glutathione transferase M1 (GSTM1), and glutathione transferase T1 (GSTT1) catalyze the bioactivation and detoxification of a wide variety of xenobiotic compounds that are mutagenic and/or carcinogenic (e.g., polycyclic aromatic hydrocarbons). Polycyclic Aromatic Hydrocarbons 234-266 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-22 19317600-1 2008 Cytochrome 1A1 (CYP1A1), glutathione transferase M1 (GSTM1), and glutathione transferase T1 (GSTT1) catalyze the bioactivation and detoxification of a wide variety of xenobiotic compounds that are mutagenic and/or carcinogenic (e.g., polycyclic aromatic hydrocarbons). Polycyclic Aromatic Hydrocarbons 234-266 glutathione S-transferase mu 1 Homo sapiens 53-58 19317600-1 2008 Cytochrome 1A1 (CYP1A1), glutathione transferase M1 (GSTM1), and glutathione transferase T1 (GSTT1) catalyze the bioactivation and detoxification of a wide variety of xenobiotic compounds that are mutagenic and/or carcinogenic (e.g., polycyclic aromatic hydrocarbons). Polycyclic Aromatic Hydrocarbons 234-266 glutathione S-transferase theta 1 Homo sapiens 93-98 18754350-5 2008 The total PAH cancer potency (sum of BaP equivalents) was significantly higher (about 4 times) in the wood-burning homes compared with the reference homes, with BaP being the largest contributor, while phenanthrene made the largest contribution to the total PAH concentration in indoor and outdoor air. Polycyclic Aromatic Hydrocarbons 10-13 prohibitin 2 Homo sapiens 37-40 18628420-0 2008 Association of aryl hydrocarbon receptor gene polymorphisms and urinary 1-hydroxypyrene in polycyclic aromatic hydrocarbon-exposed workers. Polycyclic Aromatic Hydrocarbons 91-122 aryl hydrocarbon receptor Homo sapiens 15-40 17987396-8 2008 The development and the establishment of a toxicity equivalency factor (TEF) are used in the assessment of mixtures containing PAHs. Polycyclic Aromatic Hydrocarbons 127-131 TEF transcription factor, PAR bZIP family member Homo sapiens 43-70 17987396-8 2008 The development and the establishment of a toxicity equivalency factor (TEF) are used in the assessment of mixtures containing PAHs. Polycyclic Aromatic Hydrocarbons 127-131 TEF transcription factor, PAR bZIP family member Homo sapiens 72-75 18440362-1 2008 Microwave-assisted extraction using 1M KOH/methanol (alkaline-MAE) in combination with solid-phase extraction treatment was developed and applied to polycyclic aromatic hydrocarbons (PAHs) in a sediment sample. Polycyclic Aromatic Hydrocarbons 149-181 solute carrier family 6 member 1 Homo sapiens 62-65 18440362-1 2008 Microwave-assisted extraction using 1M KOH/methanol (alkaline-MAE) in combination with solid-phase extraction treatment was developed and applied to polycyclic aromatic hydrocarbons (PAHs) in a sediment sample. Polycyclic Aromatic Hydrocarbons 183-187 solute carrier family 6 member 1 Homo sapiens 62-65 18522035-5 2008 The aryl hydrocarbon receptor as a binding site plays an important role in PAH-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 75-78 aryl hydrocarbon receptor Homo sapiens 4-29 18295224-3 2008 ATRP-based poly(octadecyl acrylate)-grafted silica (Sil-ODA(n)-1), was used as a stationary phase in high-performance liquid chromatography (HPLC) and the chromatographic behavior was evaluated by the retention studies of polycyclic aromatic hydrocarbons (PAHs) and aromatic positional isomers. Polycyclic Aromatic Hydrocarbons 222-254 STIL centriolar assembly protein Homo sapiens 52-55 18295224-3 2008 ATRP-based poly(octadecyl acrylate)-grafted silica (Sil-ODA(n)-1), was used as a stationary phase in high-performance liquid chromatography (HPLC) and the chromatographic behavior was evaluated by the retention studies of polycyclic aromatic hydrocarbons (PAHs) and aromatic positional isomers. Polycyclic Aromatic Hydrocarbons 256-260 STIL centriolar assembly protein Homo sapiens 52-55 18295224-4 2008 Compared with previous poly(octadecyl acrylate)-grafted silica (Sil-ODA(n)), which was prepared by the "grafting-to" method, we have observed longer retention and greater selectivity for Sil-ODA(n)-1 towards PAHs event at higher temperature. Polycyclic Aromatic Hydrocarbons 208-212 STIL centriolar assembly protein Homo sapiens 64-67 18295224-4 2008 Compared with previous poly(octadecyl acrylate)-grafted silica (Sil-ODA(n)), which was prepared by the "grafting-to" method, we have observed longer retention and greater selectivity for Sil-ODA(n)-1 towards PAHs event at higher temperature. Polycyclic Aromatic Hydrocarbons 208-212 STIL centriolar assembly protein Homo sapiens 187-190 18284927-0 2008 Binding of polycyclic aromatic hydrocarbons to mutants of odorant-binding protein: a first step towards biosensors for environmental monitoring. Polycyclic Aromatic Hydrocarbons 11-43 odorant-binding protein Sus scrofa 58-81 19295093-10 2008 The health risk associated with inhalatory exposure to PAHs was assessed on the basis of Benzo(a)pyrene concentration in air and Toxic Equivalency Factor (TEF) for individual PAH. Polycyclic Aromatic Hydrocarbons 55-59 TEF transcription factor, PAR bZIP family member Homo sapiens 129-153 19295093-10 2008 The health risk associated with inhalatory exposure to PAHs was assessed on the basis of Benzo(a)pyrene concentration in air and Toxic Equivalency Factor (TEF) for individual PAH. Polycyclic Aromatic Hydrocarbons 55-59 TEF transcription factor, PAR bZIP family member Homo sapiens 155-158 19295093-10 2008 The health risk associated with inhalatory exposure to PAHs was assessed on the basis of Benzo(a)pyrene concentration in air and Toxic Equivalency Factor (TEF) for individual PAH. Polycyclic Aromatic Hydrocarbons 55-58 TEF transcription factor, PAR bZIP family member Homo sapiens 129-153 19295093-10 2008 The health risk associated with inhalatory exposure to PAHs was assessed on the basis of Benzo(a)pyrene concentration in air and Toxic Equivalency Factor (TEF) for individual PAH. Polycyclic Aromatic Hydrocarbons 55-58 TEF transcription factor, PAR bZIP family member Homo sapiens 155-158 19295093-12 2008 Carcinogenic potencies for DbA and BaP in PAH mixtures based on TEF concept were 45% and 39% respectively. Polycyclic Aromatic Hydrocarbons 42-45 TEF transcription factor, PAR bZIP family member Homo sapiens 64-67 17706349-4 2008 Linear regression analyses showed that the relationships between soil and shoot PAH concentrations were stronger for LMW-PAHs (R(2) between 0.51 and 0.92) than for HMW-PAHs (R(2) 0.02 and 0.60), suggesting that translocation for LMW-PAHs is faster than HMW-PAHs. Polycyclic Aromatic Hydrocarbons 80-83 cilia and flagella associated protein 97 Homo sapiens 164-167 17706349-4 2008 Linear regression analyses showed that the relationships between soil and shoot PAH concentrations were stronger for LMW-PAHs (R(2) between 0.51 and 0.92) than for HMW-PAHs (R(2) 0.02 and 0.60), suggesting that translocation for LMW-PAHs is faster than HMW-PAHs. Polycyclic Aromatic Hydrocarbons 80-83 cilia and flagella associated protein 97 Homo sapiens 253-256 18096571-9 2008 Taken together, these data suggest that (1) Mdm2 is a sensitive biomarker for certain types of genotoxicity, and (2) that polycyclic aromatic hydrocarbons-induced Mdm2 binding to chromatin reflects repairable damage, whereas chromatin binding of p53 Ser15 and gammaH2AX indicates more persistent DNA damage. Polycyclic Aromatic Hydrocarbons 122-154 MDM2 proto-oncogene Homo sapiens 44-48 18096571-9 2008 Taken together, these data suggest that (1) Mdm2 is a sensitive biomarker for certain types of genotoxicity, and (2) that polycyclic aromatic hydrocarbons-induced Mdm2 binding to chromatin reflects repairable damage, whereas chromatin binding of p53 Ser15 and gammaH2AX indicates more persistent DNA damage. Polycyclic Aromatic Hydrocarbons 122-154 MDM2 proto-oncogene Homo sapiens 163-167 18096571-9 2008 Taken together, these data suggest that (1) Mdm2 is a sensitive biomarker for certain types of genotoxicity, and (2) that polycyclic aromatic hydrocarbons-induced Mdm2 binding to chromatin reflects repairable damage, whereas chromatin binding of p53 Ser15 and gammaH2AX indicates more persistent DNA damage. Polycyclic Aromatic Hydrocarbons 122-154 tumor protein p53 Homo sapiens 246-249 19138945-1 2008 Dibenzo(a,l)pyrene (DBP) is among the most potent carcinogenic polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 63-95 D site albumin promoter binding protein Mus musculus 20-23 18255148-10 2008 Although annual averages for BaP did not exceed the limit value, autumn and winter BaP mass concentrations did, which calls for measures for reducing PAH emissions in the autumn and winter. Polycyclic Aromatic Hydrocarbons 150-153 prohibitin 2 Homo sapiens 83-86 18830893-5 2008 PAH induced significant secretion of IL-1beta, IL-8, and IL-12 after 24 or 48 hr of treatment, an effect reinforced by LPS stimulation; no effect on IL-10 secretion was noted. Polycyclic Aromatic Hydrocarbons 0-3 interleukin 1 beta Homo sapiens 37-45 18830893-5 2008 PAH induced significant secretion of IL-1beta, IL-8, and IL-12 after 24 or 48 hr of treatment, an effect reinforced by LPS stimulation; no effect on IL-10 secretion was noted. Polycyclic Aromatic Hydrocarbons 0-3 C-X-C motif chemokine ligand 8 Homo sapiens 47-51 18830893-9 2008 For example, PAH coating on ufCB amplified the inhibitory effect of ufCB against IL-1beta secretion but did not modify IL-8 formation. Polycyclic Aromatic Hydrocarbons 13-16 interleukin 1 beta Homo sapiens 81-89 18830893-10 2008 Moreover, PAH coating on ufCB tended to minimize the effect of LPS stimulation; this included (i) inhibition of the decrease in IL-12 secretion induced by uncoated ufCB and (ii) stimulation of IL-10 production. Polycyclic Aromatic Hydrocarbons 10-13 interleukin 10 Homo sapiens 193-198 18378296-4 2008 This study tested two hypotheses: (1) in the absence of functional CYP1A, metabolism of PAHs is shunted towards CYP1B1, which has been shown in mammals to produce more reactive metabolites of PAHs; alternatively, (2) CYP1B1 serves a protective role similar to CYP1A. Polycyclic Aromatic Hydrocarbons 88-92 cytochrome P450, family 1, subfamily A Danio rerio 67-72 18378296-4 2008 This study tested two hypotheses: (1) in the absence of functional CYP1A, metabolism of PAHs is shunted towards CYP1B1, which has been shown in mammals to produce more reactive metabolites of PAHs; alternatively, (2) CYP1B1 serves a protective role similar to CYP1A. Polycyclic Aromatic Hydrocarbons 88-92 cytochrome P450, family 1, subfamily B, polypeptide 1 Danio rerio 112-118 18378296-4 2008 This study tested two hypotheses: (1) in the absence of functional CYP1A, metabolism of PAHs is shunted towards CYP1B1, which has been shown in mammals to produce more reactive metabolites of PAHs; alternatively, (2) CYP1B1 serves a protective role similar to CYP1A. Polycyclic Aromatic Hydrocarbons 88-92 cytochrome P450, family 1, subfamily B, polypeptide 1 Danio rerio 217-223 18378296-4 2008 This study tested two hypotheses: (1) in the absence of functional CYP1A, metabolism of PAHs is shunted towards CYP1B1, which has been shown in mammals to produce more reactive metabolites of PAHs; alternatively, (2) CYP1B1 serves a protective role similar to CYP1A. Polycyclic Aromatic Hydrocarbons 88-92 cytochrome P450, family 1, subfamily A Danio rerio 260-265 18378296-4 2008 This study tested two hypotheses: (1) in the absence of functional CYP1A, metabolism of PAHs is shunted towards CYP1B1, which has been shown in mammals to produce more reactive metabolites of PAHs; alternatively, (2) CYP1B1 serves a protective role similar to CYP1A. Polycyclic Aromatic Hydrocarbons 192-196 cytochrome P450, family 1, subfamily B, polypeptide 1 Danio rerio 112-118 18381355-10 2008 Taken together, these results suggest that PXR plays an important role in protection against DNA damage by polycyclic aromatic hydrocarbons (PAHs) such as BaP, and that these protective effects may be through a coordinated regulation of genes involved in xenobiotic metabolism. Polycyclic Aromatic Hydrocarbons 107-139 nuclear receptor subfamily 1 group I member 2 Homo sapiens 43-46 18381355-10 2008 Taken together, these results suggest that PXR plays an important role in protection against DNA damage by polycyclic aromatic hydrocarbons (PAHs) such as BaP, and that these protective effects may be through a coordinated regulation of genes involved in xenobiotic metabolism. Polycyclic Aromatic Hydrocarbons 141-145 nuclear receptor subfamily 1 group I member 2 Homo sapiens 43-46 18353537-3 2008 We evaluated the influence of diesel exhaust particulate matter on PAH-induced cytochrome P450 (CYP) activity, PAH-DNA adduct formation, expression of certain candidate genes and the frequency of tumor initiation in the two-stage Sencar mouse model. Polycyclic Aromatic Hydrocarbons 67-70 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 79-94 18605575-7 2008 LFT sampling rates were estimated using ratios, in situ calibration and modeling for over 45 target analytes, including PAHs, PCBs, and pesticides. Polycyclic Aromatic Hydrocarbons 120-124 limb and CNS expressed 1 Homo sapiens 0-3 18589972-1 2008 We investigated enrichment with salicylate as a method to stimulate the degradation of polycyclic aromatic hydrocarbons (PAHs) by a microbial communityfrom a bioreactortreating PAH-contaminated soil. Polycyclic Aromatic Hydrocarbons 87-119 phenylalanine hydroxylase Homo sapiens 121-124 18477646-1 2008 Many studies have investigated the effects of glutathione S-transferase (GST) polymorphisms on cancer incidence in people exposed to carcinogenic polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 146-178 glutathione S-transferase kappa 1 Homo sapiens 46-71 18477646-1 2008 Many studies have investigated the effects of glutathione S-transferase (GST) polymorphisms on cancer incidence in people exposed to carcinogenic polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 146-178 glutathione S-transferase kappa 1 Homo sapiens 73-76 18477646-1 2008 Many studies have investigated the effects of glutathione S-transferase (GST) polymorphisms on cancer incidence in people exposed to carcinogenic polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 180-184 glutathione S-transferase kappa 1 Homo sapiens 46-71 18477646-1 2008 Many studies have investigated the effects of glutathione S-transferase (GST) polymorphisms on cancer incidence in people exposed to carcinogenic polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 180-184 glutathione S-transferase kappa 1 Homo sapiens 73-76 18477646-2 2008 The basis for this is that the carcinogenic bay region diol epoxide metabolites of several PAH are detoxified by GSTs in in vitro studies. Polycyclic Aromatic Hydrocarbons 91-94 glutathione S-transferase kappa 1 Homo sapiens 113-117 18473744-4 2008 SULT 2A1 mainly sulfonates DHEA and some steroids, with hydroxy derivatives of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 79-111 sulfotransferase family 2A member 1 Homo sapiens 0-8 18308702-1 2008 Cytochrome P450 1B1 (CYP1B1) is a heme-containing monooxygenase that metabolizes various polycyclic aromatic hydrocarbons and aryl amines, as well as retinoic acid and steroid hormones. Polycyclic Aromatic Hydrocarbons 89-121 cytochrome P450, family 1, subfamily B, polypeptide 1 Danio rerio 0-19 18308702-1 2008 Cytochrome P450 1B1 (CYP1B1) is a heme-containing monooxygenase that metabolizes various polycyclic aromatic hydrocarbons and aryl amines, as well as retinoic acid and steroid hormones. Polycyclic Aromatic Hydrocarbons 89-121 cytochrome P450, family 1, subfamily B, polypeptide 1 Danio rerio 21-27 18311955-0 2008 Reactive uptake of NO3, N2O5, NO2, HNO3, and O3 on three types of polycyclic aromatic hydrocarbon surfaces. Polycyclic Aromatic Hydrocarbons 66-97 NBL1, DAN family BMP antagonist Homo sapiens 19-22 18311955-1 2008 We investigated the reactive uptake of NO3, N2O5, NO2, HNO3, and O3 on three types of solid polycyclic aromatic hydrocarbons (PAHs) using a coated wall flow tube reactor coupled to a chemical ionization mass spectrometer. Polycyclic Aromatic Hydrocarbons 92-124 NBL1, DAN family BMP antagonist Homo sapiens 39-42 18311955-1 2008 We investigated the reactive uptake of NO3, N2O5, NO2, HNO3, and O3 on three types of solid polycyclic aromatic hydrocarbons (PAHs) using a coated wall flow tube reactor coupled to a chemical ionization mass spectrometer. Polycyclic Aromatic Hydrocarbons 126-130 NBL1, DAN family BMP antagonist Homo sapiens 39-42 18311955-3 2008 Reaction of NO3 radicals with all three PAHs was observed to be very fast with the reactive uptake coefficient, gamma, ranging from 0.059 (+0.11/-0.049) for benz[a]anthracene at 273 K to 0.79 (+0.21/-0.67) for pyrene at room temperature. Polycyclic Aromatic Hydrocarbons 40-44 NBL1, DAN family BMP antagonist Homo sapiens 12-15 18311955-6 2008 Reaction of NO3 on all three PAH surfaces slowed down at 263 K after long NO3 exposure times, suggesting that the PAH molecules were reactants. Polycyclic Aromatic Hydrocarbons 29-32 NBL1, DAN family BMP antagonist Homo sapiens 12-15 18311955-6 2008 Reaction of NO3 on all three PAH surfaces slowed down at 263 K after long NO3 exposure times, suggesting that the PAH molecules were reactants. Polycyclic Aromatic Hydrocarbons 29-32 NBL1, DAN family BMP antagonist Homo sapiens 74-77 18311955-6 2008 Reaction of NO3 on all three PAH surfaces slowed down at 263 K after long NO3 exposure times, suggesting that the PAH molecules were reactants. Polycyclic Aromatic Hydrocarbons 114-117 NBL1, DAN family BMP antagonist Homo sapiens 12-15 18311955-8 2008 Our results show that under certain atmospheric conditions, NO3 radicals can be a more important sink for PAHs than NO2, HNO3, N2O5, or O3 and impact tropospheric lifetimes of surface-bound PAHs. Polycyclic Aromatic Hydrocarbons 106-110 NBL1, DAN family BMP antagonist Homo sapiens 60-63 18311955-8 2008 Our results show that under certain atmospheric conditions, NO3 radicals can be a more important sink for PAHs than NO2, HNO3, N2O5, or O3 and impact tropospheric lifetimes of surface-bound PAHs. Polycyclic Aromatic Hydrocarbons 190-194 NBL1, DAN family BMP antagonist Homo sapiens 60-63 18336843-9 2008 Our results seem to indicate that inflammatory conditions might enhance genotoxic effects of carcinogenic polycyclic aromatic hydrocarbons through upregulation of CYP1B1 expression. Polycyclic Aromatic Hydrocarbons 106-138 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 163-169 18272200-8 2008 A closer examination of individual PAH results indicated that both techniques overestimated the availability of large molecules with logK(ow)>6 suggesting a biological mechanism limiting uptake of larger PAHs which seems to be related to the molecular size of compounds. Polycyclic Aromatic Hydrocarbons 207-211 phenylalanine hydroxylase Homo sapiens 35-38 18385878-4 2008 The total PAH concentrations (2- to 6-ring parent and alkylated PAHs, including the 16 US EPA PAHs) were less than 150 microg kg(-1) dry weight and their composition indicated a predominantly pyrolytic input to the basin in 2002. Polycyclic Aromatic Hydrocarbons 64-68 phenylalanine hydroxylase Homo sapiens 10-13 17932951-1 2008 The polycyclic aromatic hydrocarbons (PAHs) dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) are environmental contaminants and potent carcinogens. Polycyclic Aromatic Hydrocarbons 4-36 D-box binding PAR bZIP transcription factor Homo sapiens 64-67 17932951-1 2008 The polycyclic aromatic hydrocarbons (PAHs) dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) are environmental contaminants and potent carcinogens. Polycyclic Aromatic Hydrocarbons 38-42 D-box binding PAR bZIP transcription factor Homo sapiens 64-67 17449565-2 2008 In this context, the analytical and diagnostical reliability of 3-hydroxybenzo[a]pyrene (3OH-BaP) as a biomarker of internal exposure to PAHs was established. Polycyclic Aromatic Hydrocarbons 137-141 prohibitin 2 Homo sapiens 93-96 18628420-8 2008 Multivariate analysis of covariance revealed that the levels of 1-OHP in PAH-exposed workers carrying genotype CT were lower than workers carrying wild genotype TT at loci rs10250822 and rs2282885 of AhR gene (P = 0.032 and 0.044, respectively). Polycyclic Aromatic Hydrocarbons 73-76 aryl hydrocarbon receptor Homo sapiens 200-203 18628420-11 2008 Our findings indicated that polymorphisms of AhR gene were associated with the level of 1-OHP among PAH-exposed workers, suggesting that AhR-mediated signaling might contribute to individual susceptibility to PAH exposure. Polycyclic Aromatic Hydrocarbons 100-103 aryl hydrocarbon receptor Homo sapiens 45-48 18628420-11 2008 Our findings indicated that polymorphisms of AhR gene were associated with the level of 1-OHP among PAH-exposed workers, suggesting that AhR-mediated signaling might contribute to individual susceptibility to PAH exposure. Polycyclic Aromatic Hydrocarbons 100-103 aryl hydrocarbon receptor Homo sapiens 137-140 18628420-11 2008 Our findings indicated that polymorphisms of AhR gene were associated with the level of 1-OHP among PAH-exposed workers, suggesting that AhR-mediated signaling might contribute to individual susceptibility to PAH exposure. Polycyclic Aromatic Hydrocarbons 209-212 aryl hydrocarbon receptor Homo sapiens 45-48 18628420-11 2008 Our findings indicated that polymorphisms of AhR gene were associated with the level of 1-OHP among PAH-exposed workers, suggesting that AhR-mediated signaling might contribute to individual susceptibility to PAH exposure. Polycyclic Aromatic Hydrocarbons 209-212 aryl hydrocarbon receptor Homo sapiens 137-140 18204078-1 2008 Many studies using mammalian cellular and subcellular systems have demonstrated that polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), are metabolically activated by cytochrome P450s (CYPs). Polycyclic Aromatic Hydrocarbons 85-117 prohibitin 2 Homo sapiens 145-148 19568886-4 2008 Here, we have reviewed various aspects of CYPs for biomonitoring environmental health in terms of the CYP substrates, such as PAHs, aromatic amines, benzene/toluene, and tobacco smoking-related nitrosamines. Polycyclic Aromatic Hydrocarbons 126-130 peptidylprolyl isomerase G Homo sapiens 42-45 18067928-1 2008 Cytochrome P4501B1 (CYP1B1), a polycyclic aromatic hydrocarbon (PAH) metabolizing CYP, is genetically polymorphic in humans and may be involved in the individual susceptibility to chemical-induced cancer. Polycyclic Aromatic Hydrocarbons 31-62 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-18 18067928-1 2008 Cytochrome P4501B1 (CYP1B1), a polycyclic aromatic hydrocarbon (PAH) metabolizing CYP, is genetically polymorphic in humans and may be involved in the individual susceptibility to chemical-induced cancer. Polycyclic Aromatic Hydrocarbons 31-62 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 20-26 18067928-1 2008 Cytochrome P4501B1 (CYP1B1), a polycyclic aromatic hydrocarbon (PAH) metabolizing CYP, is genetically polymorphic in humans and may be involved in the individual susceptibility to chemical-induced cancer. Polycyclic Aromatic Hydrocarbons 64-67 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-18 18067928-1 2008 Cytochrome P4501B1 (CYP1B1), a polycyclic aromatic hydrocarbon (PAH) metabolizing CYP, is genetically polymorphic in humans and may be involved in the individual susceptibility to chemical-induced cancer. Polycyclic Aromatic Hydrocarbons 64-67 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 20-26 18078967-0 2008 Rats fed soy protein isolate (SPI) have impaired hepatic CYP1A1 induction by polycyclic aromatic hydrocarbons as a result of interference with aryl hydrocarbon receptor signaling. Polycyclic Aromatic Hydrocarbons 77-109 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 57-63 18494146-8 2008 The cellular functions of these PAH-responsive genes included: xenobiotic metabolism (CYP1A1 and CYP1B1), DNA repair (ERCC5), oxidative stress response and cell proliferation (FTH1 and PRDX1), protein degradation (PSMD7), ion transport (FXYD3), steroid biosynthesis (FDFT1), and signaling pathways (PTGER3). Polycyclic Aromatic Hydrocarbons 32-35 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 18494146-8 2008 The cellular functions of these PAH-responsive genes included: xenobiotic metabolism (CYP1A1 and CYP1B1), DNA repair (ERCC5), oxidative stress response and cell proliferation (FTH1 and PRDX1), protein degradation (PSMD7), ion transport (FXYD3), steroid biosynthesis (FDFT1), and signaling pathways (PTGER3). Polycyclic Aromatic Hydrocarbons 32-35 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 97-103 18494146-8 2008 The cellular functions of these PAH-responsive genes included: xenobiotic metabolism (CYP1A1 and CYP1B1), DNA repair (ERCC5), oxidative stress response and cell proliferation (FTH1 and PRDX1), protein degradation (PSMD7), ion transport (FXYD3), steroid biosynthesis (FDFT1), and signaling pathways (PTGER3). Polycyclic Aromatic Hydrocarbons 32-35 ERCC excision repair 5, endonuclease Homo sapiens 118-123 18494146-8 2008 The cellular functions of these PAH-responsive genes included: xenobiotic metabolism (CYP1A1 and CYP1B1), DNA repair (ERCC5), oxidative stress response and cell proliferation (FTH1 and PRDX1), protein degradation (PSMD7), ion transport (FXYD3), steroid biosynthesis (FDFT1), and signaling pathways (PTGER3). Polycyclic Aromatic Hydrocarbons 32-35 ferritin heavy chain 1 Homo sapiens 176-180 18494146-8 2008 The cellular functions of these PAH-responsive genes included: xenobiotic metabolism (CYP1A1 and CYP1B1), DNA repair (ERCC5), oxidative stress response and cell proliferation (FTH1 and PRDX1), protein degradation (PSMD7), ion transport (FXYD3), steroid biosynthesis (FDFT1), and signaling pathways (PTGER3). Polycyclic Aromatic Hydrocarbons 32-35 peroxiredoxin 1 Homo sapiens 185-190 18494146-8 2008 The cellular functions of these PAH-responsive genes included: xenobiotic metabolism (CYP1A1 and CYP1B1), DNA repair (ERCC5), oxidative stress response and cell proliferation (FTH1 and PRDX1), protein degradation (PSMD7), ion transport (FXYD3), steroid biosynthesis (FDFT1), and signaling pathways (PTGER3). Polycyclic Aromatic Hydrocarbons 32-35 proteasome 26S subunit, non-ATPase 7 Homo sapiens 214-219 18494146-8 2008 The cellular functions of these PAH-responsive genes included: xenobiotic metabolism (CYP1A1 and CYP1B1), DNA repair (ERCC5), oxidative stress response and cell proliferation (FTH1 and PRDX1), protein degradation (PSMD7), ion transport (FXYD3), steroid biosynthesis (FDFT1), and signaling pathways (PTGER3). Polycyclic Aromatic Hydrocarbons 32-35 FXYD domain containing ion transport regulator 3 Homo sapiens 237-242 18494146-8 2008 The cellular functions of these PAH-responsive genes included: xenobiotic metabolism (CYP1A1 and CYP1B1), DNA repair (ERCC5), oxidative stress response and cell proliferation (FTH1 and PRDX1), protein degradation (PSMD7), ion transport (FXYD3), steroid biosynthesis (FDFT1), and signaling pathways (PTGER3). Polycyclic Aromatic Hydrocarbons 32-35 farnesyl-diphosphate farnesyltransferase 1 Homo sapiens 267-272 18494146-8 2008 The cellular functions of these PAH-responsive genes included: xenobiotic metabolism (CYP1A1 and CYP1B1), DNA repair (ERCC5), oxidative stress response and cell proliferation (FTH1 and PRDX1), protein degradation (PSMD7), ion transport (FXYD3), steroid biosynthesis (FDFT1), and signaling pathways (PTGER3). Polycyclic Aromatic Hydrocarbons 32-35 prostaglandin E receptor 3 Homo sapiens 299-305 18178302-5 2008 Moreover, VOC and/or PAH coated onto PM induced gene expression of cytochrome P450 (cyp) 1a1, cyp2e1, nadph quinone oxydo-reductase-1, and glutathione S-transferase-pi 1 and mu 3, versus controls, suggesting thereby the formation of biologically reactive metabolites. Polycyclic Aromatic Hydrocarbons 21-24 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 67-92 18178302-5 2008 Moreover, VOC and/or PAH coated onto PM induced gene expression of cytochrome P450 (cyp) 1a1, cyp2e1, nadph quinone oxydo-reductase-1, and glutathione S-transferase-pi 1 and mu 3, versus controls, suggesting thereby the formation of biologically reactive metabolites. Polycyclic Aromatic Hydrocarbons 21-24 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 94-100 18178302-5 2008 Moreover, VOC and/or PAH coated onto PM induced gene expression of cytochrome P450 (cyp) 1a1, cyp2e1, nadph quinone oxydo-reductase-1, and glutathione S-transferase-pi 1 and mu 3, versus controls, suggesting thereby the formation of biologically reactive metabolites. Polycyclic Aromatic Hydrocarbons 21-24 glutathione S-transferase pi 1 Homo sapiens 139-178 18207300-8 2008 AKR1C2 was constitutively expressed in HepG2 cells and was not regulated by 1-NP or B[a]P. In conclusion, this is the first report on AKRs" actions toward nitro-PAH in cells. Polycyclic Aromatic Hydrocarbons 161-164 aldo-keto reductase family 1 member C2 Homo sapiens 0-6 20727282-1 2008 BACKGROUND: GSTM1 takes part in the metabolism of environmental pollutants such as benzopyrene, other polycyclic aromatic hydrocarbons and anticancer drugs and so on. Polycyclic Aromatic Hydrocarbons 102-134 glutathione S-transferase mu 1 Homo sapiens 12-17 18086550-1 2008 Halogenated and polycyclic aromatic hydrocarbons, exogenous ligands of the aryl hydrocarbon receptor (AhR), cause various toxicological effects through the transformation of the AhR. Polycyclic Aromatic Hydrocarbons 16-48 aryl-hydrocarbon receptor Mus musculus 75-100 18086550-1 2008 Halogenated and polycyclic aromatic hydrocarbons, exogenous ligands of the aryl hydrocarbon receptor (AhR), cause various toxicological effects through the transformation of the AhR. Polycyclic Aromatic Hydrocarbons 16-48 aryl-hydrocarbon receptor Mus musculus 102-105 18086550-1 2008 Halogenated and polycyclic aromatic hydrocarbons, exogenous ligands of the aryl hydrocarbon receptor (AhR), cause various toxicological effects through the transformation of the AhR. Polycyclic Aromatic Hydrocarbons 16-48 aryl-hydrocarbon receptor Mus musculus 178-181 17570583-3 2008 Naphthalene was adopted as a model compound to examine the adsorption effectiveness for removing PAHs from the aqueous solution by CR-1. Polycyclic Aromatic Hydrocarbons 97-101 complement C3b/C4b receptor 1 (Knops blood group) Homo sapiens 131-135 17874067-1 2008 Polycyclic aromatic hydrocarbons (PAH) are known to be specific inducers of CYP1A1 expression in vertebrates. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 76-82 17896209-8 2008 A significantly higher level of PAH-DNA adduct was found in subjects with wild-type ERCC2 than those who have either heterozygous or homozygous variant alleles (p < 0.01). Polycyclic Aromatic Hydrocarbons 32-35 ERCC excision repair 2, TFIIH core complex helicase subunit Homo sapiens 84-89 17874067-1 2008 Polycyclic aromatic hydrocarbons (PAH) are known to be specific inducers of CYP1A1 expression in vertebrates. Polycyclic Aromatic Hydrocarbons 34-37 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 76-82 17874067-2 2008 CYP1A1 induction has been widely studied in mammal cell cultures or in vivo, in conditions of exposure to single PAH chemicals. Polycyclic Aromatic Hydrocarbons 113-116 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 17874067-7 2008 The results showed that ingestion of PAH-contaminated mussels induced CYP1A1 mRNA and EROD activity. Polycyclic Aromatic Hydrocarbons 37-40 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 70-76 17961608-4 2008 With exception of dibenzo[a,l]pyrene, and partly also benzo[g]chrysene and benz[a]anthracene, all other PAHs under the study induced high levels of CYP1A1 and CYP1B1 mRNA. Polycyclic Aromatic Hydrocarbons 104-108 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 148-154 18039810-4 2008 PAH increased gene expression 23-fold, but the presence of dexamethasone only induced PAH-dependent expression by 1.5-fold, suggesting interaction between GR and the aryl hydrocarbon (Ah) receptor. Polycyclic Aromatic Hydrocarbons 86-89 aryl hydrocarbon receptor Rattus norvegicus 166-196 17961608-4 2008 With exception of dibenzo[a,l]pyrene, and partly also benzo[g]chrysene and benz[a]anthracene, all other PAHs under the study induced high levels of CYP1A1 and CYP1B1 mRNA. Polycyclic Aromatic Hydrocarbons 104-108 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 159-165 17919675-0 2008 Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. Polycyclic Aromatic Hydrocarbons 119-122 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 17919675-0 2008 Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. Polycyclic Aromatic Hydrocarbons 119-122 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 24-30 17919675-0 2008 Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. Polycyclic Aromatic Hydrocarbons 140-143 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 17919675-0 2008 Induction of CYP1A1 and CYP1B1 by benzo(k)fluoranthene and benzo(a)pyrene in T-47D human breast cancer cells: roles of PAH interactions and PAH metabolites. Polycyclic Aromatic Hydrocarbons 140-143 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 24-30 17920237-0 2008 Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size. Polycyclic Aromatic Hydrocarbons 100-132 peptidylprolyl isomerase B Rattus norvegicus 17-24 17919675-8 2008 These studies indicate that the inductive effects of PAH metabolites as potent CYP1 inducers are likely to be additional important factors in PAH-CYP interactions that affect metabolism and bioactivation of other PAHs, ultimately modulating PAH toxicity and carcinogenicity. Polycyclic Aromatic Hydrocarbons 53-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-83 17919675-8 2008 These studies indicate that the inductive effects of PAH metabolites as potent CYP1 inducers are likely to be additional important factors in PAH-CYP interactions that affect metabolism and bioactivation of other PAHs, ultimately modulating PAH toxicity and carcinogenicity. Polycyclic Aromatic Hydrocarbons 142-145 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-83 17919675-8 2008 These studies indicate that the inductive effects of PAH metabolites as potent CYP1 inducers are likely to be additional important factors in PAH-CYP interactions that affect metabolism and bioactivation of other PAHs, ultimately modulating PAH toxicity and carcinogenicity. Polycyclic Aromatic Hydrocarbons 213-217 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-83 17919675-8 2008 These studies indicate that the inductive effects of PAH metabolites as potent CYP1 inducers are likely to be additional important factors in PAH-CYP interactions that affect metabolism and bioactivation of other PAHs, ultimately modulating PAH toxicity and carcinogenicity. Polycyclic Aromatic Hydrocarbons 142-145 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-83 17920042-4 2008 In order to elucidate the role of individual ADHs in the metabolism of alkylated polycyclic aromatic hydrocarbons, we expressed the various members of the human ADH family in bacteria. Polycyclic Aromatic Hydrocarbons 81-113 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 45-48 18063141-1 2008 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor through which organochlorine contaminants including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and some polycyclic aromatic hydrocarbons induce toxicity and altered gene expression. Polycyclic Aromatic Hydrocarbons 184-216 aryl hydrocarbon receptor Salmo salar 4-29 18063141-1 2008 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor through which organochlorine contaminants including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and some polycyclic aromatic hydrocarbons induce toxicity and altered gene expression. Polycyclic Aromatic Hydrocarbons 184-216 aryl hydrocarbon receptor Salmo salar 31-34 17394090-8 2008 High correlation coefficient (R2 > 0.75 for most PAHs) between the measured and predicted concentrations of PAHs suggests for the applicability of the PCA/APCS receptor modeling approach for estimation of source contribution to the PAHs in particulates. Polycyclic Aromatic Hydrocarbons 52-56 amyloid P component, serum Homo sapiens 158-162 17394090-8 2008 High correlation coefficient (R2 > 0.75 for most PAHs) between the measured and predicted concentrations of PAHs suggests for the applicability of the PCA/APCS receptor modeling approach for estimation of source contribution to the PAHs in particulates. Polycyclic Aromatic Hydrocarbons 111-115 amyloid P component, serum Homo sapiens 158-162 17394090-8 2008 High correlation coefficient (R2 > 0.75 for most PAHs) between the measured and predicted concentrations of PAHs suggests for the applicability of the PCA/APCS receptor modeling approach for estimation of source contribution to the PAHs in particulates. Polycyclic Aromatic Hydrocarbons 111-115 amyloid P component, serum Homo sapiens 158-162 18569589-3 2008 This study aimed to develop a LightCycler (LC) assay to analyze the C>G polymorphism (Ser326Cys) in exon 7 of the hOGG1 gene followed by validation of the method using DNA samples from 260 polycyclic aromatic hydrocarbons(PAH)-exposed workers with known 8-oxodGuo DNA-adduct values measured by HPLC. Polycyclic Aromatic Hydrocarbons 192-224 8-oxoguanine DNA glycosylase Homo sapiens 117-122 18350874-5 2008 Some of the target AhR agonists, including polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs), were instrumentally analyzed as well. Polycyclic Aromatic Hydrocarbons 178-182 aryl hydrocarbon receptor Homo sapiens 19-22 18569589-3 2008 This study aimed to develop a LightCycler (LC) assay to analyze the C>G polymorphism (Ser326Cys) in exon 7 of the hOGG1 gene followed by validation of the method using DNA samples from 260 polycyclic aromatic hydrocarbons(PAH)-exposed workers with known 8-oxodGuo DNA-adduct values measured by HPLC. Polycyclic Aromatic Hydrocarbons 225-228 8-oxoguanine DNA glycosylase Homo sapiens 117-122 18569589-5 2008 LC melting curve analyses of the hOGG1 exon 7 PCR product were characteristic of the probes hybridized to the non-mutated Ser-type (CC) at 65 degrees C, or to the Cys mutant (GG) at 59 degrees C. The distribution in the population of PAH-exposed workers (N=260) was 58% (CC), 38%(CG), and 4% (GG). Polycyclic Aromatic Hydrocarbons 234-237 8-oxoguanine DNA glycosylase Homo sapiens 33-38 18065724-5 2008 AhR activation induces several cytochrome P450 phase I enzymes involved, e.g. in the bioactivation of carcinogenic polycyclic aromatic hydrocarbons, like benzo[a]pyrene (BaP), and may as such stimulate DNA adduct formation of those compounds. Polycyclic Aromatic Hydrocarbons 115-147 aryl hydrocarbon receptor Homo sapiens 0-3 18302885-14 2008 CONCLUSION: Levels of HSP90 in peripheral blood lymphocytes and the degree of DNA damage increase with the rise of exposure polycyclic aromatic hydrocarbons (PAHs) dose. Polycyclic Aromatic Hydrocarbons 124-156 heat shock protein 90 alpha family class A member 1 Homo sapiens 22-27 18302885-14 2008 CONCLUSION: Levels of HSP90 in peripheral blood lymphocytes and the degree of DNA damage increase with the rise of exposure polycyclic aromatic hydrocarbons (PAHs) dose. Polycyclic Aromatic Hydrocarbons 158-162 heat shock protein 90 alpha family class A member 1 Homo sapiens 22-27 17981384-5 2007 In the current study, cytochrome P450 (CYP) 1A1 and UDP-glucuronosyltransferase (UGT) 1A1 were over-expressed in the breast cancer MCF-7 cells, and potential interactions between these enzymes and estrogen or polycyclic aromatic hydrocarbon were evaluated. Polycyclic Aromatic Hydrocarbons 209-240 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 22-47 17884947-11 2007 Together, these results indicate that the deficiency of CYP1A1 activity might be a decisive condition rendering Leydig cells secure from exogenous polycyclic aromatic hydrocarbons such as B[a]P. Polycyclic Aromatic Hydrocarbons 147-179 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-62 18037991-0 2007 Maternal exposure to polycyclic aromatic hydrocarbons diminishes murine ovarian reserve via induction of Harakiri. Polycyclic Aromatic Hydrocarbons 21-53 harakiri, BCL2 interacting protein (contains only BH3 domain) Mus musculus 105-113 17714740-3 2007 Here we extend these observations to address the following hypothesis: men who are homozygous null for glutathione-S-transferase M1 (GSTM1-) are less able to detoxify reactive metabolites of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) found in air pollution. Polycyclic Aromatic Hydrocarbons 204-236 glutathione S-transferase mu 1 Homo sapiens 103-131 18338287-2 2008 Many PAHs are metabolized by cytochrome P-4501A1 (CYP1A1), which may facilitate excretion but may activate pulmonary carcinogens. Polycyclic Aromatic Hydrocarbons 5-9 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 29-48 18338287-2 2008 Many PAHs are metabolized by cytochrome P-4501A1 (CYP1A1), which may facilitate excretion but may activate pulmonary carcinogens. Polycyclic Aromatic Hydrocarbons 5-9 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 50-56 18338287-3 2008 PAHs also stimulate their own metabolism by inducing CYP1A1. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 53-59 18338287-4 2008 Recent studies suggest that respirable coal dust exposure inhibits induction of pulmonary CYP1A1 using the model PAH beta-naphthoflavone. Polycyclic Aromatic Hydrocarbons 113-116 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 90-96 18338287-5 2008 The effect of the occupational particulate respirable crystalline silica was investigated on PAH-dependent pulmonary CYP1A1 induction. Polycyclic Aromatic Hydrocarbons 93-96 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 117-123 18338287-12 2008 Our findings suggest that in PAH-exposed rat lung, silica is a negative modifier of CYP1A1 induction and CYP2B1 activity. Polycyclic Aromatic Hydrocarbons 29-32 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 84-90 18338287-12 2008 Our findings suggest that in PAH-exposed rat lung, silica is a negative modifier of CYP1A1 induction and CYP2B1 activity. Polycyclic Aromatic Hydrocarbons 29-32 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 105-111 17707923-1 2007 Metabolic bioactivation of polycyclic aromatic hydrocarbons, such as the environmental procarcinogen benzo[a]pyrene, is catalyzed by a cytochrome P450 monooxygenase encoded by the substrate-inducible Cyp1a1 gene. Polycyclic Aromatic Hydrocarbons 27-59 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 200-206 17307802-1 2007 To test the hypothesis of interaction among genetic variants in increasing the individual risk of cancer, we have studied the cumulative effect on lung cancer risk of variants in three metabolic genes, CYP1A1, GSTM1 and GSTT1, which are involved in the metabolism of the tobacco smoke constituents and environmental contaminants, polycyclic aromatic hydrocarbons and of other lung carcinogens. Polycyclic Aromatic Hydrocarbons 330-362 glutathione S-transferase theta 1 Homo sapiens 220-225 17560072-3 2007 CYP1A1 is a major enzyme that metabolizes PAH into carcinogenic moieties. Polycyclic Aromatic Hydrocarbons 42-45 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 17982086-1 2007 The aryl hydrocarbon receptor (AhR) is part of a powerful signaling system that is triggered by xenobiotic agents such as polychlorinated hydrocarbons and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 155-187 aryl-hydrocarbon receptor Mus musculus 4-29 17982086-1 2007 The aryl hydrocarbon receptor (AhR) is part of a powerful signaling system that is triggered by xenobiotic agents such as polychlorinated hydrocarbons and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 155-187 aryl-hydrocarbon receptor Mus musculus 31-34 17982086-2 2007 Although activation of the AhR by 2,3,7,8-tetrachlorodibenzo-p-dioxin or certain polycyclic aromatic hydrocarbons can lead to immunosuppression, there is also increasing evidence that the AhR regulates certain normal developmental processes. Polycyclic Aromatic Hydrocarbons 81-113 aryl-hydrocarbon receptor Mus musculus 27-30 17638922-2 2007 Two classes of carcinogens that target the colon, heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons, are known to be detoxified by the UGT family of enzymes. Polycyclic Aromatic Hydrocarbons 81-113 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 149-152 17638922-3 2007 Recently, our laboratory demonstrated that UGT1A10 has considerably more activity against polycyclic aromatic hydrocarbons in vitro than any other UGT family member. Polycyclic Aromatic Hydrocarbons 90-122 UDP glucuronosyltransferase family 1 member A10 Homo sapiens 43-50 17638922-3 2007 Recently, our laboratory demonstrated that UGT1A10 has considerably more activity against polycyclic aromatic hydrocarbons in vitro than any other UGT family member. Polycyclic Aromatic Hydrocarbons 90-122 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 43-46 17941746-8 2007 Contribution of MeAnt and MePhe to overall AhR-inducing potencies should be taken into account in PAH-contaminated environments. Polycyclic Aromatic Hydrocarbons 98-101 aryl hydrocarbon receptor Rattus norvegicus 43-46 17941746-12 2007 In summary, inhibition of GJIC and partial activation of AhR seem to be the most prominent toxic effects of the methylated PAHs in the present study. Polycyclic Aromatic Hydrocarbons 123-127 aryl hydrocarbon receptor Rattus norvegicus 57-60 18035981-10 2007 This fact indicates that the chemokine pathway of IL-8 activity could be modulated by this treatment, most likely by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 117-149 C-X-C motif chemokine ligand 8 Homo sapiens 50-54 17716705-0 2007 The sedimentary fluxes of polycyclic aromatic hydrocarbons in the Yangtze River Estuary coastal sea for the past century. Polycyclic Aromatic Hydrocarbons 26-58 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 96-99 17716705-1 2007 Polycyclic aromatic hydrocarbons (PAHs) in two (210)Pb dated sediment cores from the coastal East China Sea, strongly influenced by the discharge from the Yangtze River, were determined to help to reconstruct the economic development over the past century in East China. Polycyclic Aromatic Hydrocarbons 0-32 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 104-107 17716705-1 2007 Polycyclic aromatic hydrocarbons (PAHs) in two (210)Pb dated sediment cores from the coastal East China Sea, strongly influenced by the discharge from the Yangtze River, were determined to help to reconstruct the economic development over the past century in East China. Polycyclic Aromatic Hydrocarbons 34-38 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 104-107 17880909-1 2007 Halogenated and polycyclic aromatic hydrocarbons induce diverse biochemical responses through the transformation of a cytosolic aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 16-48 aryl-hydrocarbon receptor Mus musculus 128-153 17880909-1 2007 Halogenated and polycyclic aromatic hydrocarbons induce diverse biochemical responses through the transformation of a cytosolic aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 16-48 aryl-hydrocarbon receptor Mus musculus 155-158 17431589-4 2007 CYP1A1 is associated with polycyclic aromatic hydrocarbon-mediated carcinogenesis and CYP2E1 with liver damage by oxidative stress. Polycyclic Aromatic Hydrocarbons 26-57 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 0-6 17909032-3 2007 Glutathione transferase pi (GSTP) catalyzes the detoxification of electrophilic diol epoxides produced by the metabolism of polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP), a common constituent of tobacco smoke. Polycyclic Aromatic Hydrocarbons 124-156 prohibitin 2 Mus musculus 181-184 17932351-6 2007 The increase associated with homozygosity of the variant alleles for XPD and ERCC1 was stronger among those with detectable PAH-DNA adduct levels (OR, 1.83; 95% CI, 1.22-2.76 and OR, 1.92; 95% CI, 1.14-3.25 for detectable versus nondetectable adducts and homozygous wild-type genotype for XPD and ERCC1, respectively). Polycyclic Aromatic Hydrocarbons 124-127 ERCC excision repair 2, TFIIH core complex helicase subunit Homo sapiens 69-72 17932351-6 2007 The increase associated with homozygosity of the variant alleles for XPD and ERCC1 was stronger among those with detectable PAH-DNA adduct levels (OR, 1.83; 95% CI, 1.22-2.76 and OR, 1.92; 95% CI, 1.14-3.25 for detectable versus nondetectable adducts and homozygous wild-type genotype for XPD and ERCC1, respectively). Polycyclic Aromatic Hydrocarbons 124-127 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 77-82 17932351-6 2007 The increase associated with homozygosity of the variant alleles for XPD and ERCC1 was stronger among those with detectable PAH-DNA adduct levels (OR, 1.83; 95% CI, 1.22-2.76 and OR, 1.92; 95% CI, 1.14-3.25 for detectable versus nondetectable adducts and homozygous wild-type genotype for XPD and ERCC1, respectively). Polycyclic Aromatic Hydrocarbons 124-127 ERCC excision repair 2, TFIIH core complex helicase subunit Homo sapiens 289-292 17932351-6 2007 The increase associated with homozygosity of the variant alleles for XPD and ERCC1 was stronger among those with detectable PAH-DNA adduct levels (OR, 1.83; 95% CI, 1.22-2.76 and OR, 1.92; 95% CI, 1.14-3.25 for detectable versus nondetectable adducts and homozygous wild-type genotype for XPD and ERCC1, respectively). Polycyclic Aromatic Hydrocarbons 124-127 ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens 297-302 17915553-3 2007 In this study, we evaluated HSPA5 activation profiles in rat glomerular mesangial cells (rGMCs) challenged with heavy metals (HgCl2 or Pb2+ acetate) or polycyclic aromatic hydrocarbons (PAHs, ie, benzo(a)pyrene [BaP]). Polycyclic Aromatic Hydrocarbons 152-184 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 28-33 17462623-9 2007 The VOC and/or PAH-coated onto PM induced significant increases in mRNA expressions of cytochrome P450 (cyp) 1a1, cyp2e1, cyp2f1, nadph quinone oxydo-reductase-1, and glutathione s-transferase-pi 1, versus controls. Polycyclic Aromatic Hydrocarbons 15-18 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 87-112 17462623-9 2007 The VOC and/or PAH-coated onto PM induced significant increases in mRNA expressions of cytochrome P450 (cyp) 1a1, cyp2e1, cyp2f1, nadph quinone oxydo-reductase-1, and glutathione s-transferase-pi 1, versus controls. Polycyclic Aromatic Hydrocarbons 15-18 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 114-120 17462623-9 2007 The VOC and/or PAH-coated onto PM induced significant increases in mRNA expressions of cytochrome P450 (cyp) 1a1, cyp2e1, cyp2f1, nadph quinone oxydo-reductase-1, and glutathione s-transferase-pi 1, versus controls. Polycyclic Aromatic Hydrocarbons 15-18 cytochrome P450 family 2 subfamily F member 1 Homo sapiens 122-128 17566624-2 2007 In two brands of smoked marc spirit the higher-molecular-weight PAHs concentrations (5 and 6 rings PAHs) resulted higher (0.09-0.3 microg L (-1)) than in whiskies (0.00-0.02 microg L(-1)) and consequently higher resulted the carcinogenic potential expressed using the toxicity equivalent factor (TEF). Polycyclic Aromatic Hydrocarbons 64-68 TEF transcription factor, PAR bZIP family member Homo sapiens 268-294 17566624-2 2007 In two brands of smoked marc spirit the higher-molecular-weight PAHs concentrations (5 and 6 rings PAHs) resulted higher (0.09-0.3 microg L (-1)) than in whiskies (0.00-0.02 microg L(-1)) and consequently higher resulted the carcinogenic potential expressed using the toxicity equivalent factor (TEF). Polycyclic Aromatic Hydrocarbons 64-68 TEF transcription factor, PAR bZIP family member Homo sapiens 296-299 17823102-3 2007 PAHs are potent inducers of the hepatic cytochrome P-450 (CYP) isoenzymes 1A1, 1A2, and, possibly, 2E1. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-56 17823102-3 2007 PAHs are potent inducers of the hepatic cytochrome P-450 (CYP) isoenzymes 1A1, 1A2, and, possibly, 2E1. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 58-61 17618724-1 2007 Aryl hydrocarbon receptor (AhR) plays important roles in the regulation and induction of xenobiotic-metabolizing enzymes including the cytochromes P450 1 family (CYP1) and UDP-glucuronosyltransferases 1A (UGT1As) by polycyclic aromatic hydrocarbons as well as chlorinated aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 216-248 aryl-hydrocarbon receptor Mus musculus 0-25 17618724-1 2007 Aryl hydrocarbon receptor (AhR) plays important roles in the regulation and induction of xenobiotic-metabolizing enzymes including the cytochromes P450 1 family (CYP1) and UDP-glucuronosyltransferases 1A (UGT1As) by polycyclic aromatic hydrocarbons as well as chlorinated aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 216-248 aryl-hydrocarbon receptor Mus musculus 27-30 17708657-0 2007 Aryl hydrocarbon receptor-mediated effects of chlorinated polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 58-90 aryl hydrocarbon receptor Homo sapiens 0-25 17708657-4 2007 All environmentally relevant 18 ClPAHs showed the AhR activities in the test; the activities were elevated with the number of chlorine atoms on the lower molecular weight PAH ( approximately three-ring and fluoranthene derivatives) but not for higher molecular weight ClPAHs (>four-ring). Polycyclic Aromatic Hydrocarbons 34-37 aryl hydrocarbon receptor Homo sapiens 50-53 17522750-0 2007 Occurrence and distribution of polycyclic aromatic hydrocarbons (PAHs) in Bolgoda and Beira Lakes, Sri Lanka. Polycyclic Aromatic Hydrocarbons 65-69 sorcin Homo sapiens 99-102 17714740-3 2007 Here we extend these observations to address the following hypothesis: men who are homozygous null for glutathione-S-transferase M1 (GSTM1-) are less able to detoxify reactive metabolites of carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) found in air pollution. Polycyclic Aromatic Hydrocarbons 204-236 glutathione S-transferase mu 1 Homo sapiens 133-138 17630984-1 2007 CYP1A1, a cytochrome P450 enzyme, metabolizes polycyclic aromatic hydrocarbons to genotoxic metabolite(s) that bind to DNA and initiate carcinogenesis. Polycyclic Aromatic Hydrocarbons 46-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 17413125-5 2007 One important xenobiotic substrate for CYP enzymes in cigarette smoke is polycyclic aromatic hydrocarbon, which in its native form is relatively harmless in small doses but upon bioactivation by CYP enzymes, can become very toxic substances for the lungs. Polycyclic Aromatic Hydrocarbons 73-104 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-42 17376491-2 2007 Previously we showed that chronic exposure of ApoE-/- mice to the prototype PAH benzo[a]pyrene (B[a]P) causes enhanced progression of atherosclerosis, which was characterised by an increased inflammatory cell content in the atherosclerotic plaques. Polycyclic Aromatic Hydrocarbons 76-79 apolipoprotein E Mus musculus 46-50 17413125-5 2007 One important xenobiotic substrate for CYP enzymes in cigarette smoke is polycyclic aromatic hydrocarbon, which in its native form is relatively harmless in small doses but upon bioactivation by CYP enzymes, can become very toxic substances for the lungs. Polycyclic Aromatic Hydrocarbons 73-104 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 195-198 17431034-1 2007 CYP1A1 and 1A2 play critical roles in the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines/amides (HAAs), respectively, to electrophilic reactive intermediates, leading to toxicity and cancer. Polycyclic Aromatic Hydrocarbons 79-111 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-14 17431034-1 2007 CYP1A1 and 1A2 play critical roles in the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons (PAHs) and heterocyclic aromatic amines/amides (HAAs), respectively, to electrophilic reactive intermediates, leading to toxicity and cancer. Polycyclic Aromatic Hydrocarbons 113-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-14 17431034-2 2007 CYP1As are highly inducible by PAHs and halogenated aromatic hydrocarbons via aryl hydrocarbon receptor-mediated gene transcription. Polycyclic Aromatic Hydrocarbons 31-35 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-4 17408702-1 2007 We analyzed the effect of exposure to carcinogenic polycyclic aromatic hydrocarbons (c-PAHs) in ambient air on the plasma levels of p53 and p21(WAF1) proteins among city policemen, bus drivers and controls in three European cities: Prague (Czech Republic), Kosice (Slovakia) and Sofia (Bulgaria). Polycyclic Aromatic Hydrocarbons 51-83 tumor protein p53 Homo sapiens 132-135 17665676-1 2007 Polycyclic aromatic ketones (PAKs) and polycyclic aromatic quinones (PAQs) are oxygenated polycyclic aromatic hydrocarbons (PAHs), and reports about the aryl hydrocarbon receptor (AhR) ligand activities of these compounds are few. Polycyclic Aromatic Hydrocarbons 90-122 aryl hydrocarbon receptor Homo sapiens 180-183 17665676-1 2007 Polycyclic aromatic ketones (PAKs) and polycyclic aromatic quinones (PAQs) are oxygenated polycyclic aromatic hydrocarbons (PAHs), and reports about the aryl hydrocarbon receptor (AhR) ligand activities of these compounds are few. Polycyclic Aromatic Hydrocarbons 124-128 aryl hydrocarbon receptor Homo sapiens 180-183 17665681-2 2007 The multidrug resistance (mdr)/permeability glycoprotein (P-gp) complex is implicated in the multidrug resistance pattern developed against various drugs and xenobiotics, including polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 181-213 Multi drug resistance 65 Drosophila melanogaster 58-62 17420030-10 2007 As THP-1 cells possess a limited metabolic capacity for most c-PAHs to form DNA reactive intermediates and are also more susceptible to toxic effects of PAHs and various EOM components, this cell line seemed to be an inappropriate system for genotoxicity studies of PAH-containing complex mixtures. Polycyclic Aromatic Hydrocarbons 63-67 GLI family zinc finger 2 Homo sapiens 3-8 17431010-1 2007 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxic effects of halogenated aromatic hydrocarbons (HAHs), polycyclic aromatic hydrocarbons (PAHs), and other structurally diverse ligands. Polycyclic Aromatic Hydrocarbons 179-211 aryl hydrocarbon receptor Rattus norvegicus 4-29 17607366-2 2007 On the other hand, CYP1A1 can also produce highly carcinogenic intermediate metabolites through oxidation of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 109-141 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 19-25 17490615-0 2007 AhR- and c-maf-dependent induction of beta7-integrin expression in human macrophages in response to environmental polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 114-146 aryl hydrocarbon receptor Homo sapiens 0-3 17490615-0 2007 AhR- and c-maf-dependent induction of beta7-integrin expression in human macrophages in response to environmental polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 114-146 MAF bZIP transcription factor Homo sapiens 9-14 17548691-5 2007 After adjusting for smoking status, carrying the putative "high-risk" genotype combination, the faster metabolism of PAH-epoxides to PAH-diol-epoxides (CYP1B1 432Val/Val and mEH 139Arg/Arg) with lower PAH-diol-epoxide conjugation (GSTP1 (105)Ile/Ile), was associated with increased adducts only in Caucasian nontumor cells (0.2363 +/- 0.0132 versus 0.1920 +/- 0.0157; P= 0.05). Polycyclic Aromatic Hydrocarbons 117-120 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 152-158 17548691-5 2007 After adjusting for smoking status, carrying the putative "high-risk" genotype combination, the faster metabolism of PAH-epoxides to PAH-diol-epoxides (CYP1B1 432Val/Val and mEH 139Arg/Arg) with lower PAH-diol-epoxide conjugation (GSTP1 (105)Ile/Ile), was associated with increased adducts only in Caucasian nontumor cells (0.2363 +/- 0.0132 versus 0.1920 +/- 0.0157; P= 0.05). Polycyclic Aromatic Hydrocarbons 117-120 epoxide hydrolase 1, microsomal Mus musculus 174-177 17548691-5 2007 After adjusting for smoking status, carrying the putative "high-risk" genotype combination, the faster metabolism of PAH-epoxides to PAH-diol-epoxides (CYP1B1 432Val/Val and mEH 139Arg/Arg) with lower PAH-diol-epoxide conjugation (GSTP1 (105)Ile/Ile), was associated with increased adducts only in Caucasian nontumor cells (0.2363 +/- 0.0132 versus 0.1920 +/- 0.0157; P= 0.05). Polycyclic Aromatic Hydrocarbons 117-120 glutathione S-transferase pi 1 Homo sapiens 231-236 17330842-0 2007 Role of GSTT1 deletion in DNA oxidative damage by exposure to polycyclic aromatic hydrocarbons in humans. Polycyclic Aromatic Hydrocarbons 62-94 glutathione S-transferase theta 1 Homo sapiens 8-13 17330842-3 2007 The GSTT1 homozygous deletion variant was associated with a significant protective effect for exposure to total PAHs and to eight specific PAHs, although the magnitude and significance of the effect varied among these compounds. Polycyclic Aromatic Hydrocarbons 112-116 glutathione S-transferase theta 1 Homo sapiens 4-9 17330842-3 2007 The GSTT1 homozygous deletion variant was associated with a significant protective effect for exposure to total PAHs and to eight specific PAHs, although the magnitude and significance of the effect varied among these compounds. Polycyclic Aromatic Hydrocarbons 139-143 glutathione S-transferase theta 1 Homo sapiens 4-9 17330842-4 2007 Categorical sensitivity analysis was used to determine that the frequency of the GSTT1 deletion was significantly higher in people who proved to be more resistant to the DNA damaging effects of PAH exposure than in people who were the most sensitive. Polycyclic Aromatic Hydrocarbons 194-197 glutathione S-transferase theta 1 Homo sapiens 81-86 17330842-6 2007 The mechanism for this effect might be related to specific PAH substrate specificities, or could be related to other functions of GSTT1 gene in oxidative stress induced damage pathways. Polycyclic Aromatic Hydrocarbons 59-62 glutathione S-transferase theta 1 Homo sapiens 130-135 17306283-3 2007 In this study, the supercritical fluid (carbon dioxide) extraction (SFE) technique, with and without methanol modifier, was used for removal of PAHs (phenanthrene) from kaolinite, illite, and montmorillonite soils. Polycyclic Aromatic Hydrocarbons 144-148 membrane metalloendopeptidase Homo sapiens 68-71 17547212-3 2007 PAHs are agonists for AhR and are predominantly responsible for lung cancer through induction of highly carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 0-4 aryl-hydrocarbon receptor Mus musculus 22-25 17547212-4 2007 PAH metabolization requires CYP1A1 induction through activation of AhR, and therefore we hypothesized that carcinogenesis due to PAHs in APM would be reduced in AhR-/- mice. Polycyclic Aromatic Hydrocarbons 0-3 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 28-34 17547212-4 2007 PAH metabolization requires CYP1A1 induction through activation of AhR, and therefore we hypothesized that carcinogenesis due to PAHs in APM would be reduced in AhR-/- mice. Polycyclic Aromatic Hydrocarbons 0-3 aryl-hydrocarbon receptor Mus musculus 67-70 17547212-4 2007 PAH metabolization requires CYP1A1 induction through activation of AhR, and therefore we hypothesized that carcinogenesis due to PAHs in APM would be reduced in AhR-/- mice. Polycyclic Aromatic Hydrocarbons 0-3 aryl-hydrocarbon receptor Mus musculus 161-164 17547212-9 2007 We also show that PAH-like compounds are major contributors to AhR-mediated carcinogenesis, whereas TCDD and related compounds make a smaller contribution. Polycyclic Aromatic Hydrocarbons 18-21 aryl-hydrocarbon receptor Mus musculus 63-66 17573710-1 2007 The activation by the carcinogenic polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) of transcription factors NF-kappaB and AP-1 in hepatoma 27 and HepG2 cell cultures was studied. Polycyclic Aromatic Hydrocarbons 35-66 nuclear factor kappa B subunit 1 Homo sapiens 118-127 17573710-1 2007 The activation by the carcinogenic polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) of transcription factors NF-kappaB and AP-1 in hepatoma 27 and HepG2 cell cultures was studied. Polycyclic Aromatic Hydrocarbons 35-66 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 132-136 17573710-1 2007 The activation by the carcinogenic polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) of transcription factors NF-kappaB and AP-1 in hepatoma 27 and HepG2 cell cultures was studied. Polycyclic Aromatic Hydrocarbons 68-71 nuclear factor kappa B subunit 1 Homo sapiens 118-127 17573710-1 2007 The activation by the carcinogenic polycyclic aromatic hydrocarbon (PAH) benzo[a]pyrene (BP) of transcription factors NF-kappaB and AP-1 in hepatoma 27 and HepG2 cell cultures was studied. Polycyclic Aromatic Hydrocarbons 68-71 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 132-136 17431010-1 2007 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxic effects of halogenated aromatic hydrocarbons (HAHs), polycyclic aromatic hydrocarbons (PAHs), and other structurally diverse ligands. Polycyclic Aromatic Hydrocarbons 179-211 aryl hydrocarbon receptor Rattus norvegicus 31-34 17431010-1 2007 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxic effects of halogenated aromatic hydrocarbons (HAHs), polycyclic aromatic hydrocarbons (PAHs), and other structurally diverse ligands. Polycyclic Aromatic Hydrocarbons 213-217 aryl hydrocarbon receptor Rattus norvegicus 4-29 17431010-1 2007 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates many of the biological and toxic effects of halogenated aromatic hydrocarbons (HAHs), polycyclic aromatic hydrocarbons (PAHs), and other structurally diverse ligands. Polycyclic Aromatic Hydrocarbons 213-217 aryl hydrocarbon receptor Rattus norvegicus 31-34 17633179-5 2007 Significant positive correlations between partition coefficients (Koc), which was defined as the ratio of PAH isomers concentrations in surface sediment to those in seawater, and their octanol/water partition coefficients (Kow) were observed, i. e., the sorption constant Koc of PAHs in the bay may be predictd by the Kow for the compounds analyzed. Polycyclic Aromatic Hydrocarbons 279-283 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 66-69 17440990-1 2007 CYP1A1 and CYP1B1 are the inducible forms of cytochrome P450 expressed in extrahepatic tissues, which are responsible for the biotransformation of polycyclic aromatic hydrocarbons, heterocyclic amines and estradiol to the carcinogenic intermediates. Polycyclic Aromatic Hydrocarbons 147-179 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 17440990-1 2007 CYP1A1 and CYP1B1 are the inducible forms of cytochrome P450 expressed in extrahepatic tissues, which are responsible for the biotransformation of polycyclic aromatic hydrocarbons, heterocyclic amines and estradiol to the carcinogenic intermediates. Polycyclic Aromatic Hydrocarbons 147-179 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 11-17 17378560-2 2007 We report on a particularly selective adsorption process of hexa-peri-hexabenzocoronene on Au(111), which leads to well-controlled adsorption position and orientation of the polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 174-206 hexosaminidase subunit alpha Homo sapiens 60-64 17082176-1 2007 NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 222-254 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 17082176-1 2007 NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 222-254 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 17082176-1 2007 NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 222-254 epoxide hydrolase 1 Homo sapiens 44-72 17082176-1 2007 NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 222-254 epoxide hydrolase 1 Homo sapiens 74-79 17082176-1 2007 NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 222-254 epoxide hydrolase 1, microsomal Mus musculus 86-89 17082176-1 2007 NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 256-260 NAD(P)H quinone dehydrogenase 1 Homo sapiens 0-32 17082176-1 2007 NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 256-260 NAD(P)H quinone dehydrogenase 1 Homo sapiens 34-38 17082176-1 2007 NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 256-260 epoxide hydrolase 1 Homo sapiens 44-72 17082176-1 2007 NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 256-260 epoxide hydrolase 1 Homo sapiens 74-79 17082176-1 2007 NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 256-260 epoxide hydrolase 1, microsomal Mus musculus 86-89 17454117-0 2007 Polycyclic aromatic hydrocarbons (PAHs) in meat products and estimated PAH intake by children and the general population in Estonia. Polycyclic Aromatic Hydrocarbons 0-32 phenylalanine hydroxylase Homo sapiens 34-37 17292855-0 2007 Evaluation of cytochrome P450(BSbeta) reactivity against polycyclic aromatic hydrocarbons and drugs. Polycyclic Aromatic Hydrocarbons 57-89 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 14-37 17292855-1 2007 The oxidation of 10 polycyclic aromatic hydrocarbons (PAH) by cytochrome P450(BSbeta) using three different electron acceptors is reported. Polycyclic Aromatic Hydrocarbons 20-52 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 62-85 17292855-1 2007 The oxidation of 10 polycyclic aromatic hydrocarbons (PAH) by cytochrome P450(BSbeta) using three different electron acceptors is reported. Polycyclic Aromatic Hydrocarbons 54-57 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 62-85 17292855-2 2007 Three PAH were found to be substrates for the oxidation by P450(BSbeta), namely anthracene, 9-methyl-anthracene and azulene. Polycyclic Aromatic Hydrocarbons 6-9 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 59-71 17306278-1 2007 The thermodynamic retention behaviour of a linear series of polycyclic aromatic hydrocarbons (PAHs) was investigated on C18 and selected phenyl-type reversed-phase stationary phases, namely C18, C18 Aqua, Propyl-phenyl and Synergi polar-RP stationary phases, using methanol mobile phases. Polycyclic Aromatic Hydrocarbons 94-98 Bardet-Biedl syndrome 9 Homo sapiens 120-123 17373502-7 2007 A new PAH partitioning model, Kd = KLB-C(1 - ftar)alpha + ftarKtar (alpha = empirical exponent), incorporates these effects in which the control of PAH partitioning transits from being dominated by sorption in lampblack (KLB-C) to absorption in oil tar (Ktar), depending on the fraction of tar (ftar). Polycyclic Aromatic Hydrocarbons 6-9 klotho beta Homo sapiens 35-38 17373502-7 2007 A new PAH partitioning model, Kd = KLB-C(1 - ftar)alpha + ftarKtar (alpha = empirical exponent), incorporates these effects in which the control of PAH partitioning transits from being dominated by sorption in lampblack (KLB-C) to absorption in oil tar (Ktar), depending on the fraction of tar (ftar). Polycyclic Aromatic Hydrocarbons 6-9 klotho beta Homo sapiens 221-224 17373502-7 2007 A new PAH partitioning model, Kd = KLB-C(1 - ftar)alpha + ftarKtar (alpha = empirical exponent), incorporates these effects in which the control of PAH partitioning transits from being dominated by sorption in lampblack (KLB-C) to absorption in oil tar (Ktar), depending on the fraction of tar (ftar). Polycyclic Aromatic Hydrocarbons 148-151 klotho beta Homo sapiens 35-38 17373502-7 2007 A new PAH partitioning model, Kd = KLB-C(1 - ftar)alpha + ftarKtar (alpha = empirical exponent), incorporates these effects in which the control of PAH partitioning transits from being dominated by sorption in lampblack (KLB-C) to absorption in oil tar (Ktar), depending on the fraction of tar (ftar). Polycyclic Aromatic Hydrocarbons 148-151 klotho beta Homo sapiens 221-224 17633616-0 2007 [Concentration characteristics and influencing factors of atmospheric polycyclic aromatic hydrocarbons in TSP in the southeastern suburb of Beijing, China]. Polycyclic Aromatic Hydrocarbons 70-102 thrombospondin 1 Homo sapiens 106-109 17178432-1 2007 The principal objective was to ascertain whether precision-cut tissue slices can be used to evaluate the potential of chemicals to induce CYP1, epoxide hydrolase and glutathione S-transferase activities, all being important enzymes involved in the metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 262-294 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 138-142 17308111-3 2007 Our previous works have shown the primordial role of NHE1 in carcinogenic PAH-induced apoptosis. Polycyclic Aromatic Hydrocarbons 74-77 solute carrier family 9 member A1 Homo sapiens 53-57 17308111-9 2007 Taken together, our findings suggest that, on BaP exposure, MKK4/JNK targets NHE1 with consequences on HKII protein, which might thus be a key protein during carcinogenic PAH apoptosis. Polycyclic Aromatic Hydrocarbons 171-174 prohibitin 2 Homo sapiens 46-49 17308111-9 2007 Taken together, our findings suggest that, on BaP exposure, MKK4/JNK targets NHE1 with consequences on HKII protein, which might thus be a key protein during carcinogenic PAH apoptosis. Polycyclic Aromatic Hydrocarbons 171-174 mitogen-activated protein kinase kinase 4 Homo sapiens 60-64 17308111-9 2007 Taken together, our findings suggest that, on BaP exposure, MKK4/JNK targets NHE1 with consequences on HKII protein, which might thus be a key protein during carcinogenic PAH apoptosis. Polycyclic Aromatic Hydrocarbons 171-174 mitogen-activated protein kinase 8 Homo sapiens 65-68 17308111-9 2007 Taken together, our findings suggest that, on BaP exposure, MKK4/JNK targets NHE1 with consequences on HKII protein, which might thus be a key protein during carcinogenic PAH apoptosis. Polycyclic Aromatic Hydrocarbons 171-174 solute carrier family 9 member A1 Homo sapiens 77-81 17308111-9 2007 Taken together, our findings suggest that, on BaP exposure, MKK4/JNK targets NHE1 with consequences on HKII protein, which might thus be a key protein during carcinogenic PAH apoptosis. Polycyclic Aromatic Hydrocarbons 171-174 hexokinase 2 Homo sapiens 103-107 17593721-3 2007 ENC1 showed higher BET surface area, higher nitrogen-accessible micropore volume, and lower mass of extractable organic chemicals, including quantifiable polycyclic aromatic hydrocarbons (PAHs),while the two chars showed identical surface oxygen/ carbon (O/C) ratio. Polycyclic Aromatic Hydrocarbons 154-186 ectodermal-neural cortex 1 Homo sapiens 0-4 17593721-3 2007 ENC1 showed higher BET surface area, higher nitrogen-accessible micropore volume, and lower mass of extractable organic chemicals, including quantifiable polycyclic aromatic hydrocarbons (PAHs),while the two chars showed identical surface oxygen/ carbon (O/C) ratio. Polycyclic Aromatic Hydrocarbons 188-192 ectodermal-neural cortex 1 Homo sapiens 0-4 17593721-5 2007 For the solid-phase compounds (1,4-dichlorobenzene (1,4-DCB) and two PAHs), sorption was statistically higher with ENC1, thus demonstrating sorption effects due to both (1) authigenic organic content in the sorbentand (2)the sorbate"s condensed state. Polycyclic Aromatic Hydrocarbons 69-73 ectodermal-neural cortex 1 Homo sapiens 115-119 17141280-0 2007 The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells. Polycyclic Aromatic Hydrocarbons 86-118 aryl hydrocarbon receptor Rattus norvegicus 4-29 17141280-11 2007 Transfection of WB-F344 cells with siRNA targeted against AhR decreased induction of Cyclin A induced by BbF or BaP, further supporting the role of AhR in proliferative effects of PAHs. Polycyclic Aromatic Hydrocarbons 180-184 aryl hydrocarbon receptor Rattus norvegicus 58-61 17141280-11 2007 Transfection of WB-F344 cells with siRNA targeted against AhR decreased induction of Cyclin A induced by BbF or BaP, further supporting the role of AhR in proliferative effects of PAHs. Polycyclic Aromatic Hydrocarbons 180-184 aryl hydrocarbon receptor Rattus norvegicus 148-151 17285163-6 2007 Toxic potency assessment of soil PAHs presented a good relationship with benzo(a)pyrene (BaP) levels, toxic equivalent concentrations based on BaP (TEQ(BaP)) and dioxin-like toxic equivalent concentrations (TEQ(TCDD)). Polycyclic Aromatic Hydrocarbons 33-37 prohibitin 2 Homo sapiens 89-92 17285163-6 2007 Toxic potency assessment of soil PAHs presented a good relationship with benzo(a)pyrene (BaP) levels, toxic equivalent concentrations based on BaP (TEQ(BaP)) and dioxin-like toxic equivalent concentrations (TEQ(TCDD)). Polycyclic Aromatic Hydrocarbons 33-37 prohibitin 2 Homo sapiens 143-146 17285163-6 2007 Toxic potency assessment of soil PAHs presented a good relationship with benzo(a)pyrene (BaP) levels, toxic equivalent concentrations based on BaP (TEQ(BaP)) and dioxin-like toxic equivalent concentrations (TEQ(TCDD)). Polycyclic Aromatic Hydrocarbons 33-37 prohibitin 2 Homo sapiens 143-146 17285163-7 2007 The study highlights that BaP is a good indicator for assessing the potential toxicity of PAHs, and presents a promising toxicity assessment method for soil PAHs. Polycyclic Aromatic Hydrocarbons 90-94 prohibitin 2 Homo sapiens 26-29 17560011-4 2007 The formation of polycyclic aromatic hydrocarbon (PAH)-DNA adducts and the expression of PAH-metabolizing enzymes cytochrome P450 (CYP) 1A1 and arylhydrocarbon receptor (AhR) were detected by Western blot and/or quantitative RT-PCR. Polycyclic Aromatic Hydrocarbons 17-48 aryl hydrocarbon receptor Homo sapiens 170-173 17560011-4 2007 The formation of polycyclic aromatic hydrocarbon (PAH)-DNA adducts and the expression of PAH-metabolizing enzymes cytochrome P450 (CYP) 1A1 and arylhydrocarbon receptor (AhR) were detected by Western blot and/or quantitative RT-PCR. Polycyclic Aromatic Hydrocarbons 89-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 114-139 17560011-4 2007 The formation of polycyclic aromatic hydrocarbon (PAH)-DNA adducts and the expression of PAH-metabolizing enzymes cytochrome P450 (CYP) 1A1 and arylhydrocarbon receptor (AhR) were detected by Western blot and/or quantitative RT-PCR. Polycyclic Aromatic Hydrocarbons 89-92 aryl hydrocarbon receptor Homo sapiens 144-168 17187366-0 2007 Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar. Polycyclic Aromatic Hydrocarbons 111-114 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 17187366-0 2007 Competitive inhibition of carcinogen-activating CYP1A1 and CYP1B1 enzymes by a standardized complex mixture of PAH extracted from coal tar. Polycyclic Aromatic Hydrocarbons 111-114 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 59-65 17187366-1 2007 A complex mixture of polycyclic aromatic hydrocarbons (PAH) extracted from coal tar, the Standard Reference Material (SRM) 1597, was recently shown to decrease the levels of DNA binding of the 2 strong carcinogens benzo[a]pyrene (BP) and dibenzo[a,l]pyrene (DBP) in the human mammary carcinoma-derived cell line MCF-7 (Mahadevan et al., Chem Res Toxicol 2005;18:224-231). Polycyclic Aromatic Hydrocarbons 21-53 D-box binding PAR bZIP transcription factor Homo sapiens 258-261 17187366-1 2007 A complex mixture of polycyclic aromatic hydrocarbons (PAH) extracted from coal tar, the Standard Reference Material (SRM) 1597, was recently shown to decrease the levels of DNA binding of the 2 strong carcinogens benzo[a]pyrene (BP) and dibenzo[a,l]pyrene (DBP) in the human mammary carcinoma-derived cell line MCF-7 (Mahadevan et al., Chem Res Toxicol 2005;18:224-231). Polycyclic Aromatic Hydrocarbons 55-58 D-box binding PAR bZIP transcription factor Homo sapiens 258-261 17269652-2 2007 The self-assembled monolayer of PAHs was investigated by STM and was used in the electrochemical detection of nitroaromatic compounds (NACs). Polycyclic Aromatic Hydrocarbons 32-36 sulfotransferase family 1A member 3 Homo sapiens 57-60 16906435-4 2007 1-Naphthol (hUGT1A6), 1-hydroxypyrene (hUGT1A6/1A9), and entacapone (hUGT1A9) are markers of PAH-glucuronidating human uridine diphosphate-glucuronosyltransferases (UGT). Polycyclic Aromatic Hydrocarbons 93-96 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 12-19 16906435-4 2007 1-Naphthol (hUGT1A6), 1-hydroxypyrene (hUGT1A6/1A9), and entacapone (hUGT1A9) are markers of PAH-glucuronidating human uridine diphosphate-glucuronosyltransferases (UGT). Polycyclic Aromatic Hydrocarbons 93-96 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 39-50 16906435-4 2007 1-Naphthol (hUGT1A6), 1-hydroxypyrene (hUGT1A6/1A9), and entacapone (hUGT1A9) are markers of PAH-glucuronidating human uridine diphosphate-glucuronosyltransferases (UGT). Polycyclic Aromatic Hydrocarbons 93-96 UDP glucuronosyltransferase family 1 member A9 Homo sapiens 69-76 16906435-4 2007 1-Naphthol (hUGT1A6), 1-hydroxypyrene (hUGT1A6/1A9), and entacapone (hUGT1A9) are markers of PAH-glucuronidating human uridine diphosphate-glucuronosyltransferases (UGT). Polycyclic Aromatic Hydrocarbons 93-96 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 119-163 16906435-4 2007 1-Naphthol (hUGT1A6), 1-hydroxypyrene (hUGT1A6/1A9), and entacapone (hUGT1A9) are markers of PAH-glucuronidating human uridine diphosphate-glucuronosyltransferases (UGT). Polycyclic Aromatic Hydrocarbons 93-96 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 13-16 16906435-13 2007 Since the 2-4-ring PAHs (major constituents) were poor enzyme inducers, it appears that the PAH-metabolizing pathways are mainly induced by BaP-type minor constituents. Polycyclic Aromatic Hydrocarbons 19-22 prohibitin 2 Rattus norvegicus 140-143 16906435-15 2007 Hence, human exposure to PAH mixtures with high content of BaP-type hydrocarbons confers a potentially higher health risk than PAH mixtures with low content of procarcinogens. Polycyclic Aromatic Hydrocarbons 25-28 prohibitin 2 Homo sapiens 59-62 17253627-1 2007 Benzo[a]pyrene (BaP) is listed as a priority pollutant by the U.S. Environmental Protection Agency because it is one of the most potent carcinogens of all known polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 161-193 prohibitin 2 Homo sapiens 16-19 17253627-1 2007 Benzo[a]pyrene (BaP) is listed as a priority pollutant by the U.S. Environmental Protection Agency because it is one of the most potent carcinogens of all known polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 195-199 prohibitin 2 Homo sapiens 16-19 17082565-0 2007 An environmental quinoid polycyclic aromatic hydrocarbon, acenaphthenequinone, modulates cyclooxygenase-2 expression through reactive oxygen species generation and nuclear factor kappa B activation in A549 cells. Polycyclic Aromatic Hydrocarbons 25-56 prostaglandin-endoperoxide synthase 2 Homo sapiens 89-105 17082565-0 2007 An environmental quinoid polycyclic aromatic hydrocarbon, acenaphthenequinone, modulates cyclooxygenase-2 expression through reactive oxygen species generation and nuclear factor kappa B activation in A549 cells. Polycyclic Aromatic Hydrocarbons 25-56 nuclear factor kappa B subunit 1 Homo sapiens 164-186 16406813-8 2007 CONCLUSION: Our study shows that exposure to urban traffic, dietary habits, and the nonnull GSTT1 genotype may contribute to interindividual variation in background levels of 1-OHP urinary excretion in subjects without occupational exposure to PAHs. Polycyclic Aromatic Hydrocarbons 244-248 glutathione S-transferase theta 1 Homo sapiens 92-97 17060372-0 2007 Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1. Polycyclic Aromatic Hydrocarbons 37-40 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 81-87 17060372-0 2007 Urban dust particulate matter alters PAH-induced carcinogenesis by inhibition of CYP1A1 and CYP1B1. Polycyclic Aromatic Hydrocarbons 37-40 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 92-98 17060372-7 2007 Induction of cytochrome P450 (CYP)1A1 and 1B1 proteins was also detected following UDPM treatment or cotreatment with B[a]P or DB[a,l]P, indicating PAH bioactivation. Polycyclic Aromatic Hydrocarbons 148-151 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-45 17060372-10 2007 Overall, these data suggest that components within complex mixtures can alter PAH-induced carcinogenesis by inhibiting CYP bioactivation and influence other genotoxic effects, such as oxidative DNA damage. Polycyclic Aromatic Hydrocarbons 78-81 peptidylprolyl isomerase G Homo sapiens 119-122 17368311-2 2007 The AhR(1) was originally identified as the receptor for the polycyclic aromatic hydrocarbon family of environmental contaminants; however, recent data indicate that the AhR binds to a variety of endogenous and exogenous compounds, including some synthetic retinoids. Polycyclic Aromatic Hydrocarbons 61-92 aryl hydrocarbon receptor Homo sapiens 4-7 17368311-2 2007 The AhR(1) was originally identified as the receptor for the polycyclic aromatic hydrocarbon family of environmental contaminants; however, recent data indicate that the AhR binds to a variety of endogenous and exogenous compounds, including some synthetic retinoids. Polycyclic Aromatic Hydrocarbons 61-92 aryl hydrocarbon receptor Homo sapiens 170-173 17112560-0 2006 Developmental toxicity of 4-ring polycyclic aromatic hydrocarbons in zebrafish is differentially dependent on AH receptor isoforms and hepatic cytochrome P4501A metabolism. Polycyclic Aromatic Hydrocarbons 33-65 cytochrome P450, family 1, subfamily A Danio rerio 143-160 17112560-2 2006 For aquatic species, PAHs are generally accepted as acting through either of two modes of action: (1) "dioxin-like" toxicity mediated by activation of the aryl hydrocarbon receptor (AHR), which controls a battery of genes involved in PAH metabolism, such as cytochrome P4501A (CYP1A) and (2) "nonpolar narcosis", in which tissue uptake is dependent solely on hydrophobicity and toxicity is mediated through non-specific partitioning into lipid bilayers. Polycyclic Aromatic Hydrocarbons 21-24 aryl hydrocarbon receptor 1a Danio rerio 155-180 17112560-2 2006 For aquatic species, PAHs are generally accepted as acting through either of two modes of action: (1) "dioxin-like" toxicity mediated by activation of the aryl hydrocarbon receptor (AHR), which controls a battery of genes involved in PAH metabolism, such as cytochrome P4501A (CYP1A) and (2) "nonpolar narcosis", in which tissue uptake is dependent solely on hydrophobicity and toxicity is mediated through non-specific partitioning into lipid bilayers. Polycyclic Aromatic Hydrocarbons 21-24 aryl hydrocarbon receptor 1a Danio rerio 182-185 17112560-2 2006 For aquatic species, PAHs are generally accepted as acting through either of two modes of action: (1) "dioxin-like" toxicity mediated by activation of the aryl hydrocarbon receptor (AHR), which controls a battery of genes involved in PAH metabolism, such as cytochrome P4501A (CYP1A) and (2) "nonpolar narcosis", in which tissue uptake is dependent solely on hydrophobicity and toxicity is mediated through non-specific partitioning into lipid bilayers. Polycyclic Aromatic Hydrocarbons 21-24 cytochrome P450, family 1, subfamily A Danio rerio 258-275 17112560-2 2006 For aquatic species, PAHs are generally accepted as acting through either of two modes of action: (1) "dioxin-like" toxicity mediated by activation of the aryl hydrocarbon receptor (AHR), which controls a battery of genes involved in PAH metabolism, such as cytochrome P4501A (CYP1A) and (2) "nonpolar narcosis", in which tissue uptake is dependent solely on hydrophobicity and toxicity is mediated through non-specific partitioning into lipid bilayers. Polycyclic Aromatic Hydrocarbons 21-24 cytochrome P450, family 1, subfamily A Danio rerio 277-282 17112560-3 2006 As part of a systematic analysis of mechanisms of PAH developmental toxicity in zebrafish, we show here that three tetracyclic PAHs (pyrene, chrysene, and benz[a]anthracene) activate the AHR pathway tissue-specifically to induce distinct patterns of CYP1A expression. Polycyclic Aromatic Hydrocarbons 50-53 aryl hydrocarbon receptor 1a Danio rerio 187-190 17112560-3 2006 As part of a systematic analysis of mechanisms of PAH developmental toxicity in zebrafish, we show here that three tetracyclic PAHs (pyrene, chrysene, and benz[a]anthracene) activate the AHR pathway tissue-specifically to induce distinct patterns of CYP1A expression. Polycyclic Aromatic Hydrocarbons 50-53 cytochrome P450, family 1, subfamily A Danio rerio 250-255 17112560-3 2006 As part of a systematic analysis of mechanisms of PAH developmental toxicity in zebrafish, we show here that three tetracyclic PAHs (pyrene, chrysene, and benz[a]anthracene) activate the AHR pathway tissue-specifically to induce distinct patterns of CYP1A expression. Polycyclic Aromatic Hydrocarbons 127-131 aryl hydrocarbon receptor 1a Danio rerio 187-190 17112560-3 2006 As part of a systematic analysis of mechanisms of PAH developmental toxicity in zebrafish, we show here that three tetracyclic PAHs (pyrene, chrysene, and benz[a]anthracene) activate the AHR pathway tissue-specifically to induce distinct patterns of CYP1A expression. Polycyclic Aromatic Hydrocarbons 127-131 cytochrome P450, family 1, subfamily A Danio rerio 250-255 17112560-6 2006 Therefore, biological effects of PAHs cannot be predicted simply by quantitative measures of AHR activity or a compound"s hydrophobicity. Polycyclic Aromatic Hydrocarbons 33-37 aryl hydrocarbon receptor 1a Danio rerio 93-96 17082565-5 2007 In this study, we estimated the intracellular ROS production and nuclear factor kappa B (NF-kappaB) translocation in A549 cells exposed to isomers of quinoid PAHs having two to four rings. Polycyclic Aromatic Hydrocarbons 158-162 nuclear factor kappa B subunit 1 Homo sapiens 65-87 16945501-1 2006 During the conduct of a study designed to determine the effect of 3-methylcholanthrene (3-MC), a synthetic polycyclic aromatic hydrocarbon (PAH) that acts through the aryl hydrocarbon receptor (AhR), on uterine contractility in Wistar rats, uterine tumors were identified in both vehicle and 3-MC-treated animals. Polycyclic Aromatic Hydrocarbons 107-138 aryl hydrocarbon receptor Rattus norvegicus 194-197 17082565-5 2007 In this study, we estimated the intracellular ROS production and nuclear factor kappa B (NF-kappaB) translocation in A549 cells exposed to isomers of quinoid PAHs having two to four rings. Polycyclic Aromatic Hydrocarbons 158-162 nuclear factor kappa B subunit 1 Homo sapiens 89-98 17158763-2 2006 Cytochrome P4501A1 (CYP1A1) gene variants may be related to an increased capacity to activate polycyclic aromatic hydrocarbons, producing highly reactive electrophilic intermediates that might damage DNA. Polycyclic Aromatic Hydrocarbons 94-126 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 17158763-2 2006 Cytochrome P4501A1 (CYP1A1) gene variants may be related to an increased capacity to activate polycyclic aromatic hydrocarbons, producing highly reactive electrophilic intermediates that might damage DNA. Polycyclic Aromatic Hydrocarbons 94-126 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 16963132-3 2006 As a part of our overall effort to identify the various P450 enzymes that are involved in the activation and detoxification of PAHs in zebrafish, therefore, we have examined the ability of recombinant zebrafish CYP1A (zCYP1A) expressed in yeast to metabolize BaP in vitro. Polycyclic Aromatic Hydrocarbons 127-131 cytochrome P450, family 1, subfamily A Danio rerio 211-216 16945501-1 2006 During the conduct of a study designed to determine the effect of 3-methylcholanthrene (3-MC), a synthetic polycyclic aromatic hydrocarbon (PAH) that acts through the aryl hydrocarbon receptor (AhR), on uterine contractility in Wistar rats, uterine tumors were identified in both vehicle and 3-MC-treated animals. Polycyclic Aromatic Hydrocarbons 140-143 aryl hydrocarbon receptor Rattus norvegicus 167-192 16945501-1 2006 During the conduct of a study designed to determine the effect of 3-methylcholanthrene (3-MC), a synthetic polycyclic aromatic hydrocarbon (PAH) that acts through the aryl hydrocarbon receptor (AhR), on uterine contractility in Wistar rats, uterine tumors were identified in both vehicle and 3-MC-treated animals. Polycyclic Aromatic Hydrocarbons 140-143 aryl hydrocarbon receptor Rattus norvegicus 194-197 17030796-2 2006 The p53 binding pattern of carcinogenic polycyclic aromatic hydrocarbons (PAHs) found in CS coincides with the p53 mutational pattern found in lung cancer, and PAHs have thus been considered to be major culprits for lung cancer. Polycyclic Aromatic Hydrocarbons 40-72 tumor protein p53 Homo sapiens 4-7 17030796-2 2006 The p53 binding pattern of carcinogenic polycyclic aromatic hydrocarbons (PAHs) found in CS coincides with the p53 mutational pattern found in lung cancer, and PAHs have thus been considered to be major culprits for lung cancer. Polycyclic Aromatic Hydrocarbons 74-78 tumor protein p53 Homo sapiens 4-7 17030796-2 2006 The p53 binding pattern of carcinogenic polycyclic aromatic hydrocarbons (PAHs) found in CS coincides with the p53 mutational pattern found in lung cancer, and PAHs have thus been considered to be major culprits for lung cancer. Polycyclic Aromatic Hydrocarbons 74-78 tumor protein p53 Homo sapiens 111-114 17030796-2 2006 The p53 binding pattern of carcinogenic polycyclic aromatic hydrocarbons (PAHs) found in CS coincides with the p53 mutational pattern found in lung cancer, and PAHs have thus been considered to be major culprits for lung cancer. Polycyclic Aromatic Hydrocarbons 160-164 tumor protein p53 Homo sapiens 4-7 16962184-2 2006 The AHR is activated by polycyclic aromatic hydrocarbon toxicants, including the pervasive teratogen and carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin). Polycyclic Aromatic Hydrocarbons 24-55 aryl-hydrocarbon receptor Mus musculus 4-7 16683249-1 2006 Our prior studies have shown that single topical treatment of repeated fish fried oil extract (RFFE), containing various polycyclic aromatic hydrocarbons (PAHs), to the dorsal epidermis of mice caused enhancement of DNA damage along with higher expression of p53 and p21WAF1 proteins and cell-cycle arrest. Polycyclic Aromatic Hydrocarbons 121-153 transformation related protein 53, pseudogene Mus musculus 259-262 16683249-1 2006 Our prior studies have shown that single topical treatment of repeated fish fried oil extract (RFFE), containing various polycyclic aromatic hydrocarbons (PAHs), to the dorsal epidermis of mice caused enhancement of DNA damage along with higher expression of p53 and p21WAF1 proteins and cell-cycle arrest. Polycyclic Aromatic Hydrocarbons 155-159 transformation related protein 53, pseudogene Mus musculus 259-262 16698029-0 2006 An assessment of the retention behaviour of polycyclic aromatic hydrocarbons on reversed phase stationary phases: selectivity and retention on C18 and phenyl-type surfaces. Polycyclic Aromatic Hydrocarbons 44-76 Bardet-Biedl syndrome 9 Homo sapiens 143-146 16972783-1 2006 The aryl hydrocarbon receptor (AhR) was identified as the receptor for polycyclic aromatic hydrocarbons and related compounds. Polycyclic Aromatic Hydrocarbons 71-103 aryl-hydrocarbon receptor Mus musculus 4-29 16972783-1 2006 The aryl hydrocarbon receptor (AhR) was identified as the receptor for polycyclic aromatic hydrocarbons and related compounds. Polycyclic Aromatic Hydrocarbons 71-103 aryl-hydrocarbon receptor Mus musculus 31-34 16978029-2 2006 One important pathway of PAH metabolism involves the detoxification of the epoxide and diol epoxide metabolites by reaction with glutathione, catalyzed by glutathione-S-transferases (GSTs). Polycyclic Aromatic Hydrocarbons 25-28 glutathione S-transferase kappa 1 Homo sapiens 183-187 16966090-0 2006 Apoptosis and Bax expression are increased by coal dust in the polycyclic aromatic hydrocarbon-exposed lung. Polycyclic Aromatic Hydrocarbons 63-94 BCL2 associated X, apoptosis regulator Rattus norvegicus 14-17 16966090-4 2006 In addition, CD was reported to suppress cytochrome P450 1A1 (CYP1A1) induction by PAHs. Polycyclic Aromatic Hydrocarbons 83-87 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 41-60 16966090-4 2006 In addition, CD was reported to suppress cytochrome P450 1A1 (CYP1A1) induction by PAHs. Polycyclic Aromatic Hydrocarbons 83-87 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 62-68 16966090-5 2006 METHODS: We investigated the hypothesis that apoptosis plays a critical role in lung injury and down-regulation of CYP1A1 induction in mixed exposures to CD and PAHs. Polycyclic Aromatic Hydrocarbons 161-165 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 115-121 16999103-0 2006 High-resolution depositional records of polycyclic aromatic hydrocarbons in the central continental shelf mud of the East China Sea. Polycyclic Aromatic Hydrocarbons 40-72 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 128-131 16704990-4 2006 The polycyclic aromatic hydrocarbon, dibenzo[a,l]pyrene (DBP), was administered to pregnant mice (15 mg/kg, gavage) on gestation day 17, and 2000 p.p.m. Polycyclic Aromatic Hydrocarbons 4-35 D site albumin promoter binding protein Mus musculus 57-60 16455197-3 2006 Main target of the study was to find out a method with which the PAH concentrations could be decreased below the Finnish guideline level for total PAHs. Polycyclic Aromatic Hydrocarbons 147-151 phenylalanine hydroxylase Homo sapiens 65-68 16830233-0 2006 Embryonic loss due to exposure to polycyclic aromatic hydrocarbons is mediated by Bax. Polycyclic Aromatic Hydrocarbons 34-66 BCL2 associated X, apoptosis regulator Homo sapiens 82-85 16830233-2 2006 Previous studies have established that polycyclic aromatic hydrocarbons (PAHs), transactivate the arylhydrocarbon receptor (AhR), leading to cell death. Polycyclic Aromatic Hydrocarbons 39-71 aryl hydrocarbon receptor Homo sapiens 98-122 16830233-2 2006 Previous studies have established that polycyclic aromatic hydrocarbons (PAHs), transactivate the arylhydrocarbon receptor (AhR), leading to cell death. Polycyclic Aromatic Hydrocarbons 39-71 aryl hydrocarbon receptor Homo sapiens 124-127 16830233-2 2006 Previous studies have established that polycyclic aromatic hydrocarbons (PAHs), transactivate the arylhydrocarbon receptor (AhR), leading to cell death. Polycyclic Aromatic Hydrocarbons 73-77 aryl hydrocarbon receptor Homo sapiens 98-122 16830233-2 2006 Previous studies have established that polycyclic aromatic hydrocarbons (PAHs), transactivate the arylhydrocarbon receptor (AhR), leading to cell death. Polycyclic Aromatic Hydrocarbons 73-77 aryl hydrocarbon receptor Homo sapiens 124-127 16918316-4 2006 GSTM1-1 is particularly relevant in the deactivation of carcinogenic intermediates of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 86-118 glutathione S-transferase mu 1 Homo sapiens 0-7 16343719-5 2006 The main PAH sources are traffic exhausts (AcPy, FL, Flu, PA, Pyr, CHR, BeP) and industrial emissions (BaP, BaA, PER, BeP, COR, CYC). Polycyclic Aromatic Hydrocarbons 9-12 cytochrome c, somatic Homo sapiens 128-131 16650473-4 2006 Crude sediment extracts, containing high concentrations of polycyclic aromatic hydrocarbons (PAHs) and moderate amounts of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) significantly stimulated expression of the CYP11B2 gene (up to 10-fold induction), and suppressed expression of 3betaHSD2 and CYP21 genes. Polycyclic Aromatic Hydrocarbons 59-91 cytochrome P450 family 11 subfamily B member 2 Homo sapiens 236-243 16650473-4 2006 Crude sediment extracts, containing high concentrations of polycyclic aromatic hydrocarbons (PAHs) and moderate amounts of polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) significantly stimulated expression of the CYP11B2 gene (up to 10-fold induction), and suppressed expression of 3betaHSD2 and CYP21 genes. Polycyclic Aromatic Hydrocarbons 59-91 cytochrome P450 family 21 subfamily A member 2 Homo sapiens 319-324 16841312-9 2006 Only nonsignificant levels of AhR-inducing contaminants (PAHs and PCBs) were found in the HA samples. Polycyclic Aromatic Hydrocarbons 57-61 aryl hydrocarbon receptor Homo sapiens 30-33 16687390-0 2006 The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish. Polycyclic Aromatic Hydrocarbons 101-133 aryl hydrocarbon receptor 1a Danio rerio 16-41 16687390-3 2006 Another class of AHR agonists of increasing concern because of their known toxicity and ubiquity in the environment is the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 123-155 aryl hydrocarbon receptor 1a Danio rerio 17-20 16687390-3 2006 Another class of AHR agonists of increasing concern because of their known toxicity and ubiquity in the environment is the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 157-161 aryl hydrocarbon receptor 1a Danio rerio 17-20 16687390-7 2006 As observed in previous studies with killifish (Fundulus heteroclitus), we demonstrate here that coexposure of zebrafish (Danio rerio) embryos to the PAH-type AHR agonist beta-naphthoflavone (BNF) and the CYP1A inhibitor alpha-naphthoflavone (ANF) significantly enhanced toxicity above that observed for single-compound exposures. Polycyclic Aromatic Hydrocarbons 150-153 aryl hydrocarbon receptor 1a Danio rerio 159-162 16687390-7 2006 As observed in previous studies with killifish (Fundulus heteroclitus), we demonstrate here that coexposure of zebrafish (Danio rerio) embryos to the PAH-type AHR agonist beta-naphthoflavone (BNF) and the CYP1A inhibitor alpha-naphthoflavone (ANF) significantly enhanced toxicity above that observed for single-compound exposures. Polycyclic Aromatic Hydrocarbons 150-153 cytochrome P450, family 1, subfamily A Danio rerio 205-210 16687390-8 2006 In order to elucidate the role of the AHR pathway in mediating synergistic toxicity of PAH mixtures to early life stages, we used a morpholino approach to knock down expression of zebrafish AHR2 and CYP1A proteins during development. Polycyclic Aromatic Hydrocarbons 87-90 aryl hydrocarbon receptor 1a Danio rerio 38-41 16687390-8 2006 In order to elucidate the role of the AHR pathway in mediating synergistic toxicity of PAH mixtures to early life stages, we used a morpholino approach to knock down expression of zebrafish AHR2 and CYP1A proteins during development. Polycyclic Aromatic Hydrocarbons 87-90 aryl hydrocarbon receptor 2 Danio rerio 190-194 16696992-8 2006 In a study with six polycyclic aromatic hydrocarbons (PAHs), enrichment factors ranged between 494 and 4555 were obtained and the detection limits were at low ppb to ppt levels. Polycyclic Aromatic Hydrocarbons 20-52 tachykinin precursor 1 Homo sapiens 166-169 16696992-8 2006 In a study with six polycyclic aromatic hydrocarbons (PAHs), enrichment factors ranged between 494 and 4555 were obtained and the detection limits were at low ppb to ppt levels. Polycyclic Aromatic Hydrocarbons 54-58 tachykinin precursor 1 Homo sapiens 166-169 16679317-1 2006 Polycyclic aromatic hydrocarbons (PAHs) are widely distributed immunotoxic environmental contaminants well known to regulate expression of pro-inflammatory cytokines such as interleukine-1beta and tumor necrosis factor-alpha. Polycyclic Aromatic Hydrocarbons 0-32 tumor necrosis factor Homo sapiens 174-224 16679317-1 2006 Polycyclic aromatic hydrocarbons (PAHs) are widely distributed immunotoxic environmental contaminants well known to regulate expression of pro-inflammatory cytokines such as interleukine-1beta and tumor necrosis factor-alpha. Polycyclic Aromatic Hydrocarbons 34-38 tumor necrosis factor Homo sapiens 174-224 16679317-3 2006 Indeed, exposure to PAHs such as benzo[a]pyrene (BP) markedly increased mRNA expression and secretion of CCL1 in primary human macrophage cultures. Polycyclic Aromatic Hydrocarbons 20-24 C-C motif chemokine ligand 1 Homo sapiens 105-109 16765461-1 2006 Exposure of fish to polycyclic aromatic hydrocarbons (PAHs) has consistently been shown to have a negative impact on reproduction (e.g. decreased spawning success, decreased ovarian somatic index (OSI) and lower circulating levels of 17beta-estradiol and vitellogenin). Polycyclic Aromatic Hydrocarbons 20-52 vitellogenin Danio rerio 255-267 16765461-1 2006 Exposure of fish to polycyclic aromatic hydrocarbons (PAHs) has consistently been shown to have a negative impact on reproduction (e.g. decreased spawning success, decreased ovarian somatic index (OSI) and lower circulating levels of 17beta-estradiol and vitellogenin). Polycyclic Aromatic Hydrocarbons 54-58 vitellogenin Danio rerio 255-267 16929648-5 2006 PCB congener dechlorination also was delayed by the addition of various polycyclic aromatic hydrocarbons (PAHs) under three reducing conditions and by surfactants, such as brij30, triton SN70, and triton N101. Polycyclic Aromatic Hydrocarbons 72-104 pyruvate carboxylase Homo sapiens 0-3 16581943-1 2006 CYP1A1, a major phase I enzyme, plays an important role in the metabolism of polycyclic aromatic hydrocarbons and in the chemical activation of xenobiotics to carcinogenic derivatives. Polycyclic Aromatic Hydrocarbons 77-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16751148-2 2006 BaP is often taken as an indicator of the presence of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 54-86 prohibitin 2 Homo sapiens 0-3 16929648-5 2006 PCB congener dechlorination also was delayed by the addition of various polycyclic aromatic hydrocarbons (PAHs) under three reducing conditions and by surfactants, such as brij30, triton SN70, and triton N101. Polycyclic Aromatic Hydrocarbons 106-110 pyruvate carboxylase Homo sapiens 0-3 16620863-6 2006 The ordered carbonyl groups present in Sil-DSG promotes multiple carbonyl pi-benzene pi interactions with guest PAHs isomers which enhance the selectivity for these compounds. Polycyclic Aromatic Hydrocarbons 112-116 STIL centriolar assembly protein Homo sapiens 39-42 16986504-1 2006 OBJECTIVE: To investigate the association between MTHFR gene variances and chromosomal damage levels in peripheral blood lymphocyte in coke-oven workers exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 164-196 methylenetetrahydrofolate reductase Homo sapiens 50-55 16986504-1 2006 OBJECTIVE: To investigate the association between MTHFR gene variances and chromosomal damage levels in peripheral blood lymphocyte in coke-oven workers exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 198-202 methylenetetrahydrofolate reductase Homo sapiens 50-55 16986504-14 2006 CONCLUSION: The haplotypes of MTHFR gene might be one genetic susceptibility factors of PAH induced chromosomal damage in coke-oven workers. Polycyclic Aromatic Hydrocarbons 88-91 methylenetetrahydrofolate reductase Homo sapiens 30-35 16631182-3 2006 Sil-co-ODA(n) showed higher selectivity for molecular shape, especially molecular planarity of PAHs than Sil-ODA(n). Polycyclic Aromatic Hydrocarbons 95-99 STIL centriolar assembly protein Homo sapiens 0-3 16551675-8 2006 Airborne benzo(a)pyrene (BaP) correlated well (r(2) = 0.971) with levels of carcinogenic 4-6 ring PAHs and was an effective marker of exposure for all industries where significant particle bound PAH levels were found and, in particular, for CTPV exposure. Polycyclic Aromatic Hydrocarbons 98-102 prohibitin 2 Homo sapiens 25-28 16551675-8 2006 Airborne benzo(a)pyrene (BaP) correlated well (r(2) = 0.971) with levels of carcinogenic 4-6 ring PAHs and was an effective marker of exposure for all industries where significant particle bound PAH levels were found and, in particular, for CTPV exposure. Polycyclic Aromatic Hydrocarbons 98-101 prohibitin 2 Homo sapiens 25-28 16510539-0 2006 Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform. Polycyclic Aromatic Hydrocarbons 82-114 UDP glucuronosyltransferase family 1 member A10 Homo sapiens 14-46 16510539-0 2006 Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform. Polycyclic Aromatic Hydrocarbons 82-114 UDP glucuronosyltransferase family 1 member A10 Homo sapiens 48-55 16510539-0 2006 Importance of UDP-glucuronosyltransferase 1A10 (UGT1A10) in the detoxification of polycyclic aromatic hydrocarbons: decreased glucuronidative activity of the UGT1A10139Lys isoform. Polycyclic Aromatic Hydrocarbons 82-114 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 48-53 16510539-10 2006 Together, these studies implicate UGT1A10 as an important detoxifier of polycyclic aromatic hydrocarbons in humans and that the UGT1A10 codon 139 polymorphism may be an important determinant in risk for tobacco-related cancers. Polycyclic Aromatic Hydrocarbons 72-104 UDP glucuronosyltransferase family 1 member A10 Homo sapiens 34-41 16786700-10 2006 These findings suggest that histone H2AX is a potential moleculartargetfor detecting the phototoxicity of PAHs more sensitively than the detection of cell viability and DSBs. Polycyclic Aromatic Hydrocarbons 106-110 H2A.X variant histone Homo sapiens 28-40 16307765-0 2006 Polycyclic aromatic hydrocarbon-induced CYP1B1 activity is suppressed by perillyl alcohol in MCF-7 cells. Polycyclic Aromatic Hydrocarbons 0-31 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 40-46 16307765-11 2006 The present study illustrated that POH might inhibit and downregulate CYP1B1, which could protect against PAH-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 106-109 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 70-76 16472762-0 2006 CYP1A1 in polycyclic aromatic hydrocarbon-induced B lymphocyte growth suppression. Polycyclic Aromatic Hydrocarbons 10-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16513642-1 2006 The aryl hydrocarbon receptor (AHR), a member of the basic helix-loop-helix/Per-Arnt-Sim (bHLH-PAS) gene family, binds a variety of polycyclic aromatic hydrocarbons and mediates their toxic effects. Polycyclic Aromatic Hydrocarbons 132-164 aryl-hydrocarbon receptor Mus musculus 4-29 16513642-1 2006 The aryl hydrocarbon receptor (AHR), a member of the basic helix-loop-helix/Per-Arnt-Sim (bHLH-PAS) gene family, binds a variety of polycyclic aromatic hydrocarbons and mediates their toxic effects. Polycyclic Aromatic Hydrocarbons 132-164 aryl-hydrocarbon receptor Mus musculus 31-34 16704060-0 2006 Cytotoxicity and aryl hydrocarbon receptor-mediated activity of n-heterocyclic polycyclic aromatic hydrocarbons: structure-activity relationships. Polycyclic Aromatic Hydrocarbons 79-111 aryl hydrocarbon receptor Homo sapiens 17-42 16704060-2 2006 Although polycyclic aromatic hydrocarbons (PAHs) and their derivatives also activate AhR, their toxic effects remain to be fully elucidated. Polycyclic Aromatic Hydrocarbons 9-41 aryl hydrocarbon receptor Homo sapiens 85-88 16704060-2 2006 Although polycyclic aromatic hydrocarbons (PAHs) and their derivatives also activate AhR, their toxic effects remain to be fully elucidated. Polycyclic Aromatic Hydrocarbons 43-47 aryl hydrocarbon receptor Homo sapiens 85-88 16792075-1 2006 A collaborative study was conducted to validate an analytical method for quantification of the 15 polycyclic aromatic hydrocarbons (PAHs) regarded in 2002 as a health concern by the former Scientific Committee on Food of the European Commission (SCF) in primary smoke condensates. Polycyclic Aromatic Hydrocarbons 98-130 KIT ligand Homo sapiens 246-249 16792075-1 2006 A collaborative study was conducted to validate an analytical method for quantification of the 15 polycyclic aromatic hydrocarbons (PAHs) regarded in 2002 as a health concern by the former Scientific Committee on Food of the European Commission (SCF) in primary smoke condensates. Polycyclic Aromatic Hydrocarbons 132-136 KIT ligand Homo sapiens 246-249 16416283-1 2006 PURPOSE: Polycyclic aromatic hydrocarbons are activated by cytochrome P450 1A1 (CYP1A1) and inactivated by glutathione S-transferase mu (GSTM1). Polycyclic Aromatic Hydrocarbons 9-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 59-78 16416283-1 2006 PURPOSE: Polycyclic aromatic hydrocarbons are activated by cytochrome P450 1A1 (CYP1A1) and inactivated by glutathione S-transferase mu (GSTM1). Polycyclic Aromatic Hydrocarbons 9-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 80-86 16416283-1 2006 PURPOSE: Polycyclic aromatic hydrocarbons are activated by cytochrome P450 1A1 (CYP1A1) and inactivated by glutathione S-transferase mu (GSTM1). Polycyclic Aromatic Hydrocarbons 9-41 glutathione S-transferase mu 1 Homo sapiens 107-135 16416283-1 2006 PURPOSE: Polycyclic aromatic hydrocarbons are activated by cytochrome P450 1A1 (CYP1A1) and inactivated by glutathione S-transferase mu (GSTM1). Polycyclic Aromatic Hydrocarbons 9-41 glutathione S-transferase mu 1 Homo sapiens 137-142 16839212-1 2006 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with which halogenated and polycyclic aromatic hydrocarbons such as dioxins and benzo[a]pyrene interact as ligands. Polycyclic Aromatic Hydrocarbons 106-138 aryl hydrocarbon receptor Rattus norvegicus 4-29 16839212-1 2006 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor with which halogenated and polycyclic aromatic hydrocarbons such as dioxins and benzo[a]pyrene interact as ligands. Polycyclic Aromatic Hydrocarbons 106-138 aryl hydrocarbon receptor Rattus norvegicus 31-34 16611024-1 2006 Cytochrome P450 (CYP) 1A1 attracts attention mainly because of its role in production of carcinogenic reactive metabolites from polycyclic aromatic hydrocarbons such as benzo[a]pyrene, but recent developments indicate its apparent role in cell cycle progression. Polycyclic Aromatic Hydrocarbons 128-160 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-25 16472762-1 2006 The AhR is a ligand-activated transcription factor that mediates immunosuppression by environmental PAH. Polycyclic Aromatic Hydrocarbons 100-103 aryl hydrocarbon receptor Homo sapiens 4-7 16472762-2 2006 Previous studies demonstrated that activation of mature human B cells up-regulates AhR expression, suggesting that human B cells are direct PAH targets. Polycyclic Aromatic Hydrocarbons 140-143 aryl hydrocarbon receptor Homo sapiens 83-86 16438934-4 2006 Such deleterious effects were abrogated using 3"-methoxy-4"-nitroflavone, a pure antagonist of the aryl hydrocarbon receptor, highlighting the involvement of this receptor in PAH toxicity towards EPCs. Polycyclic Aromatic Hydrocarbons 175-178 aryl hydrocarbon receptor Homo sapiens 99-124 16361083-1 2006 BACKGROUND: Dihydrodiol dehydrogenase (DDH) is a member of the aldo-keto reductases superfamily which may be involved in normal detoxification process of environmental mutagenic hazards like polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 191-223 dihydrodiol dehydrogenase Homo sapiens 12-37 16377763-1 2006 CYP1A1 and CYP1B1 metabolically activate many polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene, to reactive intermediates associated with toxicity, mutagenesis, and carcinogenesis. Polycyclic Aromatic Hydrocarbons 46-78 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-6 16377763-1 2006 CYP1A1 and CYP1B1 metabolically activate many polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene, to reactive intermediates associated with toxicity, mutagenesis, and carcinogenesis. Polycyclic Aromatic Hydrocarbons 46-78 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 11-17 16377763-1 2006 CYP1A1 and CYP1B1 metabolically activate many polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene, to reactive intermediates associated with toxicity, mutagenesis, and carcinogenesis. Polycyclic Aromatic Hydrocarbons 80-84 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-6 16377763-1 2006 CYP1A1 and CYP1B1 metabolically activate many polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene, to reactive intermediates associated with toxicity, mutagenesis, and carcinogenesis. Polycyclic Aromatic Hydrocarbons 80-84 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 11-17 16461351-0 2006 Effects of polycyclic aromatic hydrocarbons (PAHs) on vascular endothelial growth factor induction through phosphatidylinositol 3-kinase/AP-1-dependent, HIF-1alpha-independent pathway. Polycyclic Aromatic Hydrocarbons 11-43 vascular endothelial growth factor A Homo sapiens 54-88 16461351-0 2006 Effects of polycyclic aromatic hydrocarbons (PAHs) on vascular endothelial growth factor induction through phosphatidylinositol 3-kinase/AP-1-dependent, HIF-1alpha-independent pathway. Polycyclic Aromatic Hydrocarbons 11-43 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 137-141 16461351-0 2006 Effects of polycyclic aromatic hydrocarbons (PAHs) on vascular endothelial growth factor induction through phosphatidylinositol 3-kinase/AP-1-dependent, HIF-1alpha-independent pathway. Polycyclic Aromatic Hydrocarbons 11-43 hypoxia inducible factor 1 subunit alpha Homo sapiens 153-163 16461351-0 2006 Effects of polycyclic aromatic hydrocarbons (PAHs) on vascular endothelial growth factor induction through phosphatidylinositol 3-kinase/AP-1-dependent, HIF-1alpha-independent pathway. Polycyclic Aromatic Hydrocarbons 45-49 vascular endothelial growth factor A Homo sapiens 54-88 16461351-0 2006 Effects of polycyclic aromatic hydrocarbons (PAHs) on vascular endothelial growth factor induction through phosphatidylinositol 3-kinase/AP-1-dependent, HIF-1alpha-independent pathway. Polycyclic Aromatic Hydrocarbons 45-49 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 137-141 16461351-0 2006 Effects of polycyclic aromatic hydrocarbons (PAHs) on vascular endothelial growth factor induction through phosphatidylinositol 3-kinase/AP-1-dependent, HIF-1alpha-independent pathway. Polycyclic Aromatic Hydrocarbons 45-49 hypoxia inducible factor 1 subunit alpha Homo sapiens 153-163 16461351-3 2006 In the present study, we investigated the effects of PAHs on vascular endothelial growth factor (VEGF) expression by comparison of its induction between the active metabolite and its parent compound (B[a]PDE versus B[a]P) or between active compound and its relatively inactive analog (5-MCDE versus CDE). Polycyclic Aromatic Hydrocarbons 53-57 vascular endothelial growth factor A Homo sapiens 61-95 16461351-3 2006 In the present study, we investigated the effects of PAHs on vascular endothelial growth factor (VEGF) expression by comparison of its induction between the active metabolite and its parent compound (B[a]PDE versus B[a]P) or between active compound and its relatively inactive analog (5-MCDE versus CDE). Polycyclic Aromatic Hydrocarbons 53-57 vascular endothelial growth factor A Homo sapiens 97-101 16005925-0 2006 Activation of ERK1/2 and p38 kinases by polycyclic aromatic hydrocarbons in rat liver epithelial cells is associated with induction of apoptosis. Polycyclic Aromatic Hydrocarbons 40-72 mitogen activated protein kinase 3 Rattus norvegicus 14-20 16005925-0 2006 Activation of ERK1/2 and p38 kinases by polycyclic aromatic hydrocarbons in rat liver epithelial cells is associated with induction of apoptosis. Polycyclic Aromatic Hydrocarbons 40-72 mitogen activated protein kinase 14 Rattus norvegicus 25-28 16568750-10 2006 Underthis circumstance, a quantitative dose--effect relationship between TEQ(PAH) and EROD activity could be established, suggesting that the observed AhR effect was mostly derived from PAHs. Polycyclic Aromatic Hydrocarbons 77-80 aryl hydrocarbon receptor Rattus norvegicus 151-154 16361083-1 2006 BACKGROUND: Dihydrodiol dehydrogenase (DDH) is a member of the aldo-keto reductases superfamily which may be involved in normal detoxification process of environmental mutagenic hazards like polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 191-223 dihydrodiol dehydrogenase Homo sapiens 39-42 16361083-1 2006 BACKGROUND: Dihydrodiol dehydrogenase (DDH) is a member of the aldo-keto reductases superfamily which may be involved in normal detoxification process of environmental mutagenic hazards like polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 225-228 dihydrodiol dehydrogenase Homo sapiens 12-37 16361083-1 2006 BACKGROUND: Dihydrodiol dehydrogenase (DDH) is a member of the aldo-keto reductases superfamily which may be involved in normal detoxification process of environmental mutagenic hazards like polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 225-228 dihydrodiol dehydrogenase Homo sapiens 39-42 17017525-5 2006 CYP1A1 bioactivates polycyclic aromatic hydrocarbons to reactive DNA binding metabolites and initiates carcinogenesis. Polycyclic Aromatic Hydrocarbons 20-52 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16485905-0 2006 Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 122-154 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-39 16519321-0 2006 Drosophila melanogaster p-glycoprotein: a membrane detoxification system toward polycyclic aromatic hydrocarbon pollutants. Polycyclic Aromatic Hydrocarbons 80-111 Multi drug resistance 65 Drosophila melanogaster 24-38 16519321-2 2006 Permeability glycoprotein (P-gp) is a transmembrane detoxification efflux pump transporting various lipophilic xenobiotics, such as PAHs, out of the cells. Polycyclic Aromatic Hydrocarbons 132-136 Multi drug resistance 65 Drosophila melanogaster 0-25 16519321-2 2006 Permeability glycoprotein (P-gp) is a transmembrane detoxification efflux pump transporting various lipophilic xenobiotics, such as PAHs, out of the cells. Polycyclic Aromatic Hydrocarbons 132-136 Multi drug resistance 65 Drosophila melanogaster 27-31 16519321-3 2006 The existence of a P-gp detoxification system inducible by PAHs was investigated in Drosophila melanogaster. Polycyclic Aromatic Hydrocarbons 59-63 Multi drug resistance 65 Drosophila melanogaster 19-23 16519321-6 2006 Flow cytometry experiments using Drosophila S12 cells in the presence of PAHs and target P-gp drug compounds revealed that Drosophila P-gp acted as an efflux detoxification pump. Polycyclic Aromatic Hydrocarbons 73-77 Multi drug resistance 65 Drosophila melanogaster 134-138 16519321-7 2006 In Drosophila exposed to benzo[a]pyrene or to ambient air polluted by higher or lower PAH concentrations, P-gp expression was clearly showed a dose-dependent increase response. Polycyclic Aromatic Hydrocarbons 86-89 Multi drug resistance 65 Drosophila melanogaster 106-110 16392842-7 2006 The geometrical distortions of the BaP structure upon nitro group substitution and correlations between structural parameters and vibrational data as well as structure-function relationships related to the mutagenicity of this important class of polycyclic aromatic hydrocarbons are discussed. Polycyclic Aromatic Hydrocarbons 246-278 prohibitin 2 Homo sapiens 35-38 16427050-0 2006 Activation of p53 as a causal step for atherosclerosis induced by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 66-98 tumor protein p53 Homo sapiens 14-17 16427050-1 2006 This study was performed to prove our hypothesis that the metabolite(s) of polycyclic aromatic hydrocarbons (PAHs) caused the activation or phosphorylation of p53 via DNA damage to suppress the liver X receptor (LXR)-mediated signal transductions as a probably more direct mechanism. Polycyclic Aromatic Hydrocarbons 75-107 tumor protein p53 Homo sapiens 159-162 16427050-1 2006 This study was performed to prove our hypothesis that the metabolite(s) of polycyclic aromatic hydrocarbons (PAHs) caused the activation or phosphorylation of p53 via DNA damage to suppress the liver X receptor (LXR)-mediated signal transductions as a probably more direct mechanism. Polycyclic Aromatic Hydrocarbons 109-113 tumor protein p53 Homo sapiens 159-162 16271822-1 2006 CYP 1B1 is involved in metabolizing both polycyclic aromatic hydrocarbons and estradiol to potentially carcinogenic intermediates, and it is also over-expressed in human cancer cells. Polycyclic Aromatic Hydrocarbons 41-73 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-7 16424006-2 2006 A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was given to pregnant mice (15 mg/kg body weight, gavage) on gestation day 17. Polycyclic Aromatic Hydrocarbons 2-33 D site albumin promoter binding protein Mus musculus 61-64 16424006-2 2006 A polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DBP), was given to pregnant mice (15 mg/kg body weight, gavage) on gestation day 17. Polycyclic Aromatic Hydrocarbons 35-38 D site albumin promoter binding protein Mus musculus 61-64 16341845-13 2006 In particular, transcripts of CYP1B1 and CYP4B1 are present, coding for enzymes which are active in the metabolism of polycyclic aromatic hydrocarbons and arylamines, respectively. Polycyclic Aromatic Hydrocarbons 118-150 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 30-36 16341845-13 2006 In particular, transcripts of CYP1B1 and CYP4B1 are present, coding for enzymes which are active in the metabolism of polycyclic aromatic hydrocarbons and arylamines, respectively. Polycyclic Aromatic Hydrocarbons 118-150 cytochrome P450 family 4 subfamily B member 1 Homo sapiens 41-47 17067754-0 2006 Prostate cancer risk from occupational exposure to polycyclic aromatic hydrocarbons interacting with the GSTP1 Ile105Val polymorphism. Polycyclic Aromatic Hydrocarbons 51-83 glutathione S-transferase pi 1 Homo sapiens 105-110 17067754-1 2006 BACKGROUND: Variation in the glutathione S-transferase (GSTP1) gene and occupational polycyclic aromatic hydrocarbons (PAH) exposure are putative prostate cancer risk factors. Polycyclic Aromatic Hydrocarbons 85-117 glutathione S-transferase kappa 1 Homo sapiens 29-54 17067754-1 2006 BACKGROUND: Variation in the glutathione S-transferase (GSTP1) gene and occupational polycyclic aromatic hydrocarbons (PAH) exposure are putative prostate cancer risk factors. Polycyclic Aromatic Hydrocarbons 85-117 glutathione S-transferase pi 1 Homo sapiens 56-61 17067754-1 2006 BACKGROUND: Variation in the glutathione S-transferase (GSTP1) gene and occupational polycyclic aromatic hydrocarbons (PAH) exposure are putative prostate cancer risk factors. Polycyclic Aromatic Hydrocarbons 119-122 glutathione S-transferase kappa 1 Homo sapiens 29-54 17067754-1 2006 BACKGROUND: Variation in the glutathione S-transferase (GSTP1) gene and occupational polycyclic aromatic hydrocarbons (PAH) exposure are putative prostate cancer risk factors. Polycyclic Aromatic Hydrocarbons 119-122 glutathione S-transferase pi 1 Homo sapiens 56-61 17067754-2 2006 An Ile/Val polymorphism in codon 105 of GSTP1 affects its enzymatic activity toward PAH detoxification, a possible mechanism in prostate carcinogenesis. Polycyclic Aromatic Hydrocarbons 84-87 glutathione S-transferase pi 1 Homo sapiens 40-45 17067754-5 2006 The association of occupational PAH exposure and GSTP1 Ile105Val polymorphism with prostate cancer was tested in multiple logistic regression models adjusting for potential confounders. Polycyclic Aromatic Hydrocarbons 32-35 glutathione S-transferase pi 1 Homo sapiens 49-54 17067754-8 2006 However, case-only analyses revealed that carriage of the GSTP1 Val(105) variant allele was associated with increasing levels of occupational respiratory PAH exposures from any source and from petroleum (trend test p=0.01 for both). Polycyclic Aromatic Hydrocarbons 154-157 glutathione S-transferase pi 1 Homo sapiens 58-63 17067754-9 2006 The GSTP1 Val(105) allele was observed most frequently in cases in the highest quartile of occupational respiratory PAH exposures from petroleum (OR=1.74; 95% CI=1.11-2.72) or from any source (OR=1.85; 95% CI=1.19-2.89). Polycyclic Aromatic Hydrocarbons 116-119 glutathione S-transferase pi 1 Homo sapiens 4-9 17067754-11 2006 CONCLUSIONS: Our results suggest men who carry the GSTP1 Val(105) variant and are exposed at high levels to occupational PAH have increased risk for prostate cancer. Polycyclic Aromatic Hydrocarbons 121-124 glutathione S-transferase pi 1 Homo sapiens 51-56 16364694-1 2006 The aryl hydrocarbon receptor (AHR) and AHR repressor (AHRR) proteins regulate gene expression in response to some halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 153-185 aryl hydrocarbon receptor repressor Fundulus heteroclitus 40-53 16364694-1 2006 The aryl hydrocarbon receptor (AHR) and AHR repressor (AHRR) proteins regulate gene expression in response to some halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 153-185 aryl hydrocarbon receptor repressor Fundulus heteroclitus 55-59 16684659-1 2006 Trace metals and polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental co-contaminants and the trace metals could influence the carcinogenicity of the PAHs by altering their extent of induction of cytochromes P4501A1, 1A2, and 1B1 (CYP). Polycyclic Aromatic Hydrocarbons 17-49 peptidylprolyl isomerase G Homo sapiens 247-250 16684659-1 2006 Trace metals and polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental co-contaminants and the trace metals could influence the carcinogenicity of the PAHs by altering their extent of induction of cytochromes P4501A1, 1A2, and 1B1 (CYP). Polycyclic Aromatic Hydrocarbons 51-55 peptidylprolyl isomerase G Homo sapiens 247-250 17145695-3 2006 Evidence is summarized here showing that the tightly regulated series of genetic and biochemical events during nephrogenesis is disrupted by superactivation of aryl hydrocarbon receptor (Ahr) by benzo(a)pyrene (BaP), a ubiquitous polycyclic aromatic hydrocarbon and renal carcinogen (Falahatpisheh and Ramos, 2003). Polycyclic Aromatic Hydrocarbons 230-261 aryl-hydrocarbon receptor Mus musculus 160-185 17145695-3 2006 Evidence is summarized here showing that the tightly regulated series of genetic and biochemical events during nephrogenesis is disrupted by superactivation of aryl hydrocarbon receptor (Ahr) by benzo(a)pyrene (BaP), a ubiquitous polycyclic aromatic hydrocarbon and renal carcinogen (Falahatpisheh and Ramos, 2003). Polycyclic Aromatic Hydrocarbons 230-261 aryl-hydrocarbon receptor Mus musculus 187-190 16083312-11 2006 From the immunological markers listed above only the decreased level of alpha(2)-macroglobulin correlated to the extent of exposure to PAHs (r = -0.568, p<0.05). Polycyclic Aromatic Hydrocarbons 135-139 alpha-2-macroglobulin Homo sapiens 72-94 16719376-1 2006 Cytochrome P450 (P450) enzymes belonging to the CYP1 family are highly inducible by polycyclic aromatic hydrocarbons and other environmental chemicals and play a major role in the metabolism of many foreign chemicals and endogenous substances. Polycyclic Aromatic Hydrocarbons 84-116 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-21 16497101-10 2006 Chemokine pathway (IL-8) and TNF-alpha activity seem to be modulated by Goeckerman"s therapy (polycyclic aromatic hydrocarbons). Polycyclic Aromatic Hydrocarbons 94-126 C-X-C motif chemokine ligand 8 Homo sapiens 19-23 16211578-1 2005 Most effects of exposure to halogenated and polycyclic aromatic hydrocarbons are mediated by the aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 44-76 aryl hydrocarbon receptor Homo sapiens 97-122 16211578-1 2005 Most effects of exposure to halogenated and polycyclic aromatic hydrocarbons are mediated by the aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 44-76 aryl hydrocarbon receptor Homo sapiens 124-127 16137816-1 2005 CYP1A1 is an extrahepatic enzyme largely involved in the bioactivation of various procarcinogens such as polycyclic aromatic hydrocarbons (PAHs) and arylamines. Polycyclic Aromatic Hydrocarbons 105-137 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16137816-1 2005 CYP1A1 is an extrahepatic enzyme largely involved in the bioactivation of various procarcinogens such as polycyclic aromatic hydrocarbons (PAHs) and arylamines. Polycyclic Aromatic Hydrocarbons 139-143 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16497101-10 2006 Chemokine pathway (IL-8) and TNF-alpha activity seem to be modulated by Goeckerman"s therapy (polycyclic aromatic hydrocarbons). Polycyclic Aromatic Hydrocarbons 94-126 tumor necrosis factor Homo sapiens 29-38 16197980-1 2005 The biotransformation and mineralization of a mixture of two polycyclic aromatic hydrocarbons (PAHs), anthracene and pyrene, which are known contaminants of soil and groundwater, by an enrichment culture in the presence or absence of 100 mg l(-1) Tergitol NP-10, a non-ionic surfactant, and at temperatures of 10 degrees C and 25 degrees C were investigated. Polycyclic Aromatic Hydrocarbons 95-99 nuclear receptor subfamily 4 group A member 1 Homo sapiens 256-261 16284498-9 2005 This study suggests that maternal smoking may be a risk factor for leukaemia in children who carry CYP1A1 or GSTM1 genotypes, which might increase reactive metabolites of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 171-203 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-105 16284498-9 2005 This study suggests that maternal smoking may be a risk factor for leukaemia in children who carry CYP1A1 or GSTM1 genotypes, which might increase reactive metabolites of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 171-203 glutathione S-transferase mu 1 Homo sapiens 109-114 16202979-0 2005 CYP1A1-mediated mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 57-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 16202979-2 2005 It has been reported that the metabolic activation of PAHs by cytochrome P450 (CYP) is an important step for PAH-induced atherosclerosis. Polycyclic Aromatic Hydrocarbons 54-58 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 62-77 16202979-2 2005 It has been reported that the metabolic activation of PAHs by cytochrome P450 (CYP) is an important step for PAH-induced atherosclerosis. Polycyclic Aromatic Hydrocarbons 54-58 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 79-82 16202979-2 2005 It has been reported that the metabolic activation of PAHs by cytochrome P450 (CYP) is an important step for PAH-induced atherosclerosis. Polycyclic Aromatic Hydrocarbons 54-57 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 62-77 16202979-2 2005 It has been reported that the metabolic activation of PAHs by cytochrome P450 (CYP) is an important step for PAH-induced atherosclerosis. Polycyclic Aromatic Hydrocarbons 54-57 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 79-82 16202979-3 2005 We recently reported that PAHs down-regulated the liver X receptor (LXR) alpha-regulated genes via aryl hydrocarbon receptor (AHR) as one of the causes responsible for atherosclerosis induced by PAHs. Polycyclic Aromatic Hydrocarbons 26-30 aryl hydrocarbon receptor Homo sapiens 99-124 16202979-3 2005 We recently reported that PAHs down-regulated the liver X receptor (LXR) alpha-regulated genes via aryl hydrocarbon receptor (AHR) as one of the causes responsible for atherosclerosis induced by PAHs. Polycyclic Aromatic Hydrocarbons 26-30 aryl hydrocarbon receptor Homo sapiens 126-129 16202979-4 2005 Thus, the aim of this study was to clarify the role of CYP1A1 in the suppression of LXR-mediated signal transductions by 3-methlychoranthrene (MC), one of the PAHs. Polycyclic Aromatic Hydrocarbons 159-163 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 55-61 16202979-7 2005 Based on these lines of evidence, we propose that the metabolic activation of PAHs by CYP1A1, but not the activation of AHR by PAHs, is a direct mechanism for atherosclerosis via the suppression of LXR-mediated signal transductions. Polycyclic Aromatic Hydrocarbons 78-82 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 15856074-11 2005 Detectable PAH-DNA adducts were inversely associated with increased BaP levels in dust in the home, but positively associated with BaP levels in soil outside of the home, although CIs were wide. Polycyclic Aromatic Hydrocarbons 11-14 prohibitin 2 Homo sapiens 68-71 15856074-11 2005 Detectable PAH-DNA adducts were inversely associated with increased BaP levels in dust in the home, but positively associated with BaP levels in soil outside of the home, although CIs were wide. Polycyclic Aromatic Hydrocarbons 11-14 prohibitin 2 Homo sapiens 131-134 16207747-8 2005 Gene expression of the cell wall-loosening protein expansin was repressed, whereas gene expression of the pathogenesis related protein PR1 was induced in response to PAH exposure. Polycyclic Aromatic Hydrocarbons 166-169 pathogenesis-related protein 1 Arabidopsis thaliana 135-138 16227587-6 2005 In these lines of mice, the AhR activity was constitutively enhanced in the absence of ligands, so that any other direct effects of PAHs and their metabolites could be ignored. Polycyclic Aromatic Hydrocarbons 132-136 aryl-hydrocarbon receptor Mus musculus 28-31 15894340-5 2005 As indicated by the Phen/Ant molar ratio, the main source of PAHs is petrogenic, probably due to oil spills from shipping. Polycyclic Aromatic Hydrocarbons 61-65 solute carrier family 25 member 6 Homo sapiens 25-28 16328660-3 2005 We estimated the PAH degradation capacity of 13 soils ranging from pristine locations (total PAHs approximately 0.1 mg kg(-1)) to heavily polluted industrial sites (total PAHs approximately 400 mg kg(-1)). Polycyclic Aromatic Hydrocarbons 93-97 phenylalanine hydroxylase Homo sapiens 17-20 16153604-5 2005 Thus, the Ile462Val polymorphism in human CYP1A1 affects EPA metabolism and may contribute to interindividual variance in the local production of physiologically active fatty acid metabolites in the cardiovascular system and other extrahepatic tissues, where CYP1A1 is expressed or induced by polycyclic aromatic hydrocarbons and other xenobiotics. Polycyclic Aromatic Hydrocarbons 293-325 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-48 16153604-5 2005 Thus, the Ile462Val polymorphism in human CYP1A1 affects EPA metabolism and may contribute to interindividual variance in the local production of physiologically active fatty acid metabolites in the cardiovascular system and other extrahepatic tissues, where CYP1A1 is expressed or induced by polycyclic aromatic hydrocarbons and other xenobiotics. Polycyclic Aromatic Hydrocarbons 293-325 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 259-265 16212338-0 2005 Unassisted eta2-coordination of polycyclic aromatic hydrocarbons to platinum(II). Polycyclic Aromatic Hydrocarbons 32-64 DNA polymerase iota Homo sapiens 11-15 16105747-0 2005 GSTM1 [corrected] deletion modifies the levels of polycyclic aromatic hydrocarbon-DNA adducts in human sperm. Polycyclic Aromatic Hydrocarbons 50-81 glutathione S-transferase mu 1 Homo sapiens 0-5 16105747-5 2005 With respect to environmental factors, subjects who reported occupational exposure to PAHs and who carried the GSTM1 deletion had a significant increase in PAH-DNA adducts in sperm in comparison with subjects who were not exposed and had a functional GSTM1 (mean staining intensity: 1.83+/-0.67 versus 1.30+/-0.53; p=0.05), although among GSTM1-null subjects there was no significant difference with or without occupational exposure. Polycyclic Aromatic Hydrocarbons 86-89 glutathione S-transferase mu 1 Homo sapiens 111-116 16105747-5 2005 With respect to environmental factors, subjects who reported occupational exposure to PAHs and who carried the GSTM1 deletion had a significant increase in PAH-DNA adducts in sperm in comparison with subjects who were not exposed and had a functional GSTM1 (mean staining intensity: 1.83+/-0.67 versus 1.30+/-0.53; p=0.05), although among GSTM1-null subjects there was no significant difference with or without occupational exposure. Polycyclic Aromatic Hydrocarbons 86-89 glutathione S-transferase mu 1 Homo sapiens 251-256 16105747-5 2005 With respect to environmental factors, subjects who reported occupational exposure to PAHs and who carried the GSTM1 deletion had a significant increase in PAH-DNA adducts in sperm in comparison with subjects who were not exposed and had a functional GSTM1 (mean staining intensity: 1.83+/-0.67 versus 1.30+/-0.53; p=0.05), although among GSTM1-null subjects there was no significant difference with or without occupational exposure. Polycyclic Aromatic Hydrocarbons 86-89 glutathione S-transferase mu 1 Homo sapiens 251-256 16203253-8 2005 For a 100-ng/m3 increase in PAHs, which represented approximately two standard deviations, the percentage decrease was -3.3% [95% confidence interval (CI), -5.6 to -1.0%] for CD3+, -3.1% (95% CI, -4.9 to -1.3%) for CD4+, and -1.0% (95% CI, -1.8 to -0.2%) for CD8+ cells. Polycyclic Aromatic Hydrocarbons 28-32 CD4 molecule Homo sapiens 215-218 16365018-3 2005 PheT is the end product of the diol epoxide metabolic activation pathway of PAH, whereas HOPhe are considered as detoxification products. Polycyclic Aromatic Hydrocarbons 76-79 sperm associated antigen 9 Homo sapiens 0-4 16203253-8 2005 For a 100-ng/m3 increase in PAHs, which represented approximately two standard deviations, the percentage decrease was -3.3% [95% confidence interval (CI), -5.6 to -1.0%] for CD3+, -3.1% (95% CI, -4.9 to -1.3%) for CD4+, and -1.0% (95% CI, -1.8 to -0.2%) for CD8+ cells. Polycyclic Aromatic Hydrocarbons 28-32 CD8a molecule Homo sapiens 259-262 16393856-1 2005 2"-Amino-3"-methoxyflavone (PD98059), an MKK1 inhibitor, negatively regulates the induction of the CYP1A1 gene by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 114-146 mitogen-activated protein kinase kinase 1 Homo sapiens 41-45 16268154-0 2005 Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro CYP1A activity and polycyclic aromatic hydrocarbon-derived embryonic deformities. Polycyclic Aromatic Hydrocarbons 15-46 cytochrome P450 1A1 Fundulus heteroclitus 117-122 16393856-1 2005 2"-Amino-3"-methoxyflavone (PD98059), an MKK1 inhibitor, negatively regulates the induction of the CYP1A1 gene by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 114-146 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-105 16061200-1 2005 Polycyclic aromatic hydrocarbons (PAHs), aryl hydrocarbon receptor (AHR) ligands, induce atherogenesis. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 68-71 16061200-1 2005 Polycyclic aromatic hydrocarbons (PAHs), aryl hydrocarbon receptor (AHR) ligands, induce atherogenesis. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 68-71 16051029-2 2005 To date, dibenzo[a,l]pyrene (DBP) has been found to be the strongest tumor-initiating PAH ever tested in rodent skin and mammary tumor models. Polycyclic Aromatic Hydrocarbons 86-89 D site albumin promoter binding protein Mus musculus 29-32 16212182-0 2005 [Distribution and sources of polycyclic aromatic hydrocarbons in sediments from rivers of Pearl River Delta and its nearby South China Sea]. Polycyclic Aromatic Hydrocarbons 29-61 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 135-138 16128907-2 2005 Polycyclic aromatic hydrocarbons, present in high concentrations in tobacco smoke and charcoal-broiled meat, are known to induce CYP1A2. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 129-135 15924351-1 2005 Microsomal epoxide hydrolase (mEH) and cytochrome P450 2C9 (CYP2C9) are involved in the bioactivation and detoxification of polycyclic aromatic hydrocarbons (PAHs) derived from tobacco smoke. Polycyclic Aromatic Hydrocarbons 124-156 epoxide hydrolase 1, microsomal Mus musculus 30-33 15924351-1 2005 Microsomal epoxide hydrolase (mEH) and cytochrome P450 2C9 (CYP2C9) are involved in the bioactivation and detoxification of polycyclic aromatic hydrocarbons (PAHs) derived from tobacco smoke. Polycyclic Aromatic Hydrocarbons 124-156 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 60-66 15924351-1 2005 Microsomal epoxide hydrolase (mEH) and cytochrome P450 2C9 (CYP2C9) are involved in the bioactivation and detoxification of polycyclic aromatic hydrocarbons (PAHs) derived from tobacco smoke. Polycyclic Aromatic Hydrocarbons 158-162 epoxide hydrolase 1, microsomal Mus musculus 30-33 15924351-1 2005 Microsomal epoxide hydrolase (mEH) and cytochrome P450 2C9 (CYP2C9) are involved in the bioactivation and detoxification of polycyclic aromatic hydrocarbons (PAHs) derived from tobacco smoke. Polycyclic Aromatic Hydrocarbons 158-162 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 60-66 16054184-7 2005 In line with this, CYP2S1 has been shown to be inducible by coal tar, an abundant source of PAHs, and it was recently reported to metabolize naphthalene. Polycyclic Aromatic Hydrocarbons 92-96 cytochrome P450 family 2 subfamily S member 1 Homo sapiens 19-25 15947024-1 2005 Cytochrome P450 1A1 (CYP1A1) is induced by halogenated and polycyclic aromatic hydrocarbons following activation of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 59-91 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 15947024-1 2005 Cytochrome P450 1A1 (CYP1A1) is induced by halogenated and polycyclic aromatic hydrocarbons following activation of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 59-91 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 15947024-1 2005 Cytochrome P450 1A1 (CYP1A1) is induced by halogenated and polycyclic aromatic hydrocarbons following activation of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 59-91 aryl hydrocarbon receptor Homo sapiens 120-145 15947024-1 2005 Cytochrome P450 1A1 (CYP1A1) is induced by halogenated and polycyclic aromatic hydrocarbons following activation of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 59-91 aryl hydrocarbon receptor Homo sapiens 147-150 16320626-0 2005 Epigenetic effectiveness of complete carcinogens: specific interactions of polycyclic aromatic hydrocarbons and aminoazo dyes with cholesterol and apolipoprotein A-I. Polycyclic Aromatic Hydrocarbons 75-107 apolipoprotein A1 Homo sapiens 147-165 16320626-1 2005 During a co-precipitation of cholesterol (Chol) and slight amounts of polycyclic aromatic hydrocarbons (PAHs) or aminoazo dyes (AZOs) in aqueous albumin solution, complex particles are formed; on their surfaces apolipoproteins with an amphipathic alpha-helix (e.g. apoA-I) are more or less firmly adsorbed. Polycyclic Aromatic Hydrocarbons 104-108 apolipoprotein A1 Homo sapiens 265-271 16105209-1 2005 Surface-enhanced micro-Raman spectroscopy (micro-SERS) was used to detect traces of the hazardous pollutant polycyclic aromatic hydrocarbons (PAHs) pyrene and benzo[c]phenanthrene deposited onto a calix[4]arene-functionalized Ag colloidal surface. Polycyclic Aromatic Hydrocarbons 108-140 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 49-53 16105209-1 2005 Surface-enhanced micro-Raman spectroscopy (micro-SERS) was used to detect traces of the hazardous pollutant polycyclic aromatic hydrocarbons (PAHs) pyrene and benzo[c]phenanthrene deposited onto a calix[4]arene-functionalized Ag colloidal surface. Polycyclic Aromatic Hydrocarbons 142-146 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 49-53 15993149-1 2005 In this study, the polycyclic aromatic hydrocarbons, benzo[a]pyrene (BaP) and pyrene, were subjected to temporal ozonation. Polycyclic Aromatic Hydrocarbons 19-51 prohibitin 2 Rattus norvegicus 69-72 16922636-15 2005 Recently, it appears that a polymorphic variant CYP1B1*3/*3 relates significantly to the individual susceptibility of smokers to head and neck cancer, supporting the view that PAH are metabolically activated through CYP1B1. Polycyclic Aromatic Hydrocarbons 176-179 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 48-54 16922636-15 2005 Recently, it appears that a polymorphic variant CYP1B1*3/*3 relates significantly to the individual susceptibility of smokers to head and neck cancer, supporting the view that PAH are metabolically activated through CYP1B1. Polycyclic Aromatic Hydrocarbons 176-179 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 216-222 15939734-13 2005 Moreover, our data revealed a possible novel mechanism of PAH-mediated atherogenesis, which likely involves a TGFbeta-mediated local inflammatory reaction in the vessel wall. Polycyclic Aromatic Hydrocarbons 58-61 transforming growth factor, beta 1 Mus musculus 110-117 15860575-0 2005 Human CD34-positive hematopoietic stem cells constitute targets for carcinogenic polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 81-113 CD34 molecule Homo sapiens 6-10 15860575-3 2005 Benzo(a)pyrene (BP), a prototypical PAH, was shown to markedly impair CD34+ cell expansion and to inhibit CD34+ cell differentiation into various hematological cell lineages, including erythroid, granulomacrophagic, and megakaryocytic lineages. Polycyclic Aromatic Hydrocarbons 36-39 CD34 molecule Homo sapiens 70-74 15860575-3 2005 Benzo(a)pyrene (BP), a prototypical PAH, was shown to markedly impair CD34+ cell expansion and to inhibit CD34+ cell differentiation into various hematological cell lineages, including erythroid, granulomacrophagic, and megakaryocytic lineages. Polycyclic Aromatic Hydrocarbons 36-39 CD34 molecule Homo sapiens 106-110 16323636-13 2005 CONCLUSIONS: These results lead to the conclusion that PAHs would induce oxidative DNA damage, especially in individuals with the PON1 Q/Q genotype. Polycyclic Aromatic Hydrocarbons 55-59 paraoxonase 1 Homo sapiens 130-134 15993743-4 2005 PAH exposure activates the aryl hydrocarbon transcription activating factor (AhR), resulting in nuclear translocation, binding to the aryl hydrocarbon nuclear translocator (ARNT), which thereby increases expression of a pool of carcinogen metabolizing enzymes. Polycyclic Aromatic Hydrocarbons 0-3 aryl hydrocarbon receptor Homo sapiens 77-80 15993743-4 2005 PAH exposure activates the aryl hydrocarbon transcription activating factor (AhR), resulting in nuclear translocation, binding to the aryl hydrocarbon nuclear translocator (ARNT), which thereby increases expression of a pool of carcinogen metabolizing enzymes. Polycyclic Aromatic Hydrocarbons 0-3 aryl hydrocarbon receptor nuclear translocator Homo sapiens 173-177 16030093-1 2005 The UDP-glucuronosyltransferase 1A7 (UGT1A7) gene is polymorphic and encodes an enzyme involved in the detoxification of heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 151-183 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 4-35 16030093-1 2005 The UDP-glucuronosyltransferase 1A7 (UGT1A7) gene is polymorphic and encodes an enzyme involved in the detoxification of heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 151-183 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 37-43 16030093-1 2005 The UDP-glucuronosyltransferase 1A7 (UGT1A7) gene is polymorphic and encodes an enzyme involved in the detoxification of heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 185-188 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 4-35 16030093-1 2005 The UDP-glucuronosyltransferase 1A7 (UGT1A7) gene is polymorphic and encodes an enzyme involved in the detoxification of heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 185-188 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 37-43 16212182-1 2005 Polycyclic aromatic hydrocarbons (PAHs) are measured in surface sediments from rivers and estuary of Pearl River Delta and its nearby South China Sea. Polycyclic Aromatic Hydrocarbons 0-32 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 146-149 16212182-1 2005 Polycyclic aromatic hydrocarbons (PAHs) are measured in surface sediments from rivers and estuary of Pearl River Delta and its nearby South China Sea. Polycyclic Aromatic Hydrocarbons 34-38 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 146-149 16852515-12 2005 In the catalytic study, MAS-9-cyt c showed the highest specific activity toward the oxidation of polycyclic aromatic hydrocarbons (PAHs), which arises from the fast mass transfer rate of reaction substrate due to its large pore size. Polycyclic Aromatic Hydrocarbons 97-129 cytochrome c, somatic Homo sapiens 30-35 16852515-12 2005 In the catalytic study, MAS-9-cyt c showed the highest specific activity toward the oxidation of polycyclic aromatic hydrocarbons (PAHs), which arises from the fast mass transfer rate of reaction substrate due to its large pore size. Polycyclic Aromatic Hydrocarbons 131-135 cytochrome c, somatic Homo sapiens 30-35 16852515-16 2005 Possible mechanisms for MPS-cyt c catalytic oxidation of hydroperoxides and PAHs are proposed based on the spectroscopic characterizations of the systems. Polycyclic Aromatic Hydrocarbons 76-80 cytochrome c, somatic Homo sapiens 28-33 15958554-1 2005 Cytochrome P450 1B1 (CYP1B1), an extrahepatic enzyme inducible by smoking, is overexpressed in many tumors and catalyzes the metabolic activation of procarcinogens such as polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 172-204 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 15958554-1 2005 Cytochrome P450 1B1 (CYP1B1), an extrahepatic enzyme inducible by smoking, is overexpressed in many tumors and catalyzes the metabolic activation of procarcinogens such as polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 172-204 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 16117107-8 2005 In the CW and the AC1 soils, strong correlations were observed between the amount of PAHs biodegraded and the fraction of PAHs removed from the soils using the HPCD extraction. Polycyclic Aromatic Hydrocarbons 85-89 long intergenic non-protein coding RNA 1587 Homo sapiens 18-21 16922649-2 2005 The AhR can be activated by a wide range of classes of compounds (e.g. polycyclic aromatic hydrocarbons, benzimidazoles and flavonoids), and interacts with a number of other proteins, including nuclear hormone receptors such as the oestrogen and androgen receptors. Polycyclic Aromatic Hydrocarbons 71-103 aryl hydrocarbon receptor Homo sapiens 4-7 15941059-3 2005 Compared with conventional ODS (octadecylated silica), the Sil-DSG column showed remarkably higher selectivity for polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 115-147 STIL centriolar assembly protein Homo sapiens 59-62 15870154-1 2005 Cytochrome P-450 (CYP) 1A1 plays a key role in phase I metabolism of polycyclic aromatic hydrocarbons and in estrogen metabolism. Polycyclic Aromatic Hydrocarbons 69-101 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-26 15941059-3 2005 Compared with conventional ODS (octadecylated silica), the Sil-DSG column showed remarkably higher selectivity for polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 149-153 STIL centriolar assembly protein Homo sapiens 59-62 15953982-1 2005 OBJECTIVE: We examined whether polymorphisms of CYP1A1, which plays a role in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs), confer an increased risk of lung cancer in lifetime non-smoking Chinese women. Polycyclic Aromatic Hydrocarbons 106-138 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 15953982-1 2005 OBJECTIVE: We examined whether polymorphisms of CYP1A1, which plays a role in the metabolic activation of polycyclic aromatic hydrocarbons (PAHs), confer an increased risk of lung cancer in lifetime non-smoking Chinese women. Polycyclic Aromatic Hydrocarbons 140-144 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 48-54 15894689-7 2005 This study showed that the haplotypes derived from htSNPs in the XRCC1 gene were more likely than single SNPs to correlate with the polycyclic aromatic hydrocarbon-induced chromosome damage among coke-oven workers. Polycyclic Aromatic Hydrocarbons 132-163 X-ray repair cross complementing 1 Homo sapiens 65-70 15867280-9 2005 With regard to UGT1A1-conjugated carcinogens (e.g., heterocyclic amines, polycyclic aromatic hydrocarbons), individuals with decreased UGT1A1 activity due to the 7/7 genotype may be at greater risk for carcinogenesis, but our results imply that they also may have greater opportunity to decrease that risk through dietary intervention. Polycyclic Aromatic Hydrocarbons 73-105 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 135-141 15836631-2 2005 CYP1A1, a cytochrome P-450 enzyme, bioactivates polycyclic aromatic hydrocarbons to reactive metabolite(s) that bind to DNA and initiate carcinogenesis. Polycyclic Aromatic Hydrocarbons 48-80 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 15836631-2 2005 CYP1A1, a cytochrome P-450 enzyme, bioactivates polycyclic aromatic hydrocarbons to reactive metabolite(s) that bind to DNA and initiate carcinogenesis. Polycyclic Aromatic Hydrocarbons 48-80 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 10-26 15716483-2 2005 In this study, we have evaluated whether PAHs activate the early growth response (EGR-1) gene and bind to peroxisome proliferator-activated receptor alpha (PPAR alpha) and delta (PPAR beta/delta) in cell culture systems. Polycyclic Aromatic Hydrocarbons 41-45 early growth response 1 Rattus norvegicus 82-87 15681594-1 2005 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates immunosuppression induced by a variety of ubiquitous environmental pollutants, including polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and dioxins. Polycyclic Aromatic Hydrocarbons 182-214 aryl hydrocarbon receptor Homo sapiens 4-29 15681594-1 2005 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates immunosuppression induced by a variety of ubiquitous environmental pollutants, including polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and dioxins. Polycyclic Aromatic Hydrocarbons 182-214 aryl hydrocarbon receptor Homo sapiens 31-34 15716483-2 2005 In this study, we have evaluated whether PAHs activate the early growth response (EGR-1) gene and bind to peroxisome proliferator-activated receptor alpha (PPAR alpha) and delta (PPAR beta/delta) in cell culture systems. Polycyclic Aromatic Hydrocarbons 41-45 peroxisome proliferator activated receptor alpha Rattus norvegicus 106-154 15716483-2 2005 In this study, we have evaluated whether PAHs activate the early growth response (EGR-1) gene and bind to peroxisome proliferator-activated receptor alpha (PPAR alpha) and delta (PPAR beta/delta) in cell culture systems. Polycyclic Aromatic Hydrocarbons 41-45 peroxisome proliferator activated receptor alpha Rattus norvegicus 156-166 15716483-2 2005 In this study, we have evaluated whether PAHs activate the early growth response (EGR-1) gene and bind to peroxisome proliferator-activated receptor alpha (PPAR alpha) and delta (PPAR beta/delta) in cell culture systems. Polycyclic Aromatic Hydrocarbons 41-45 peroxisome proliferator-activated receptor delta Rattus norvegicus 179-188 15763632-1 2005 CYP1A2 regulation by polycyclic aromatic hydrocarbons (PAHs) exposure and polymorphism was investigated in 46 male volunteers from the Carboniferous Region in northern Coahuila, Mexico. Polycyclic Aromatic Hydrocarbons 21-53 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-6 15763632-1 2005 CYP1A2 regulation by polycyclic aromatic hydrocarbons (PAHs) exposure and polymorphism was investigated in 46 male volunteers from the Carboniferous Region in northern Coahuila, Mexico. Polycyclic Aromatic Hydrocarbons 55-59 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-6 15620718-1 2005 Glucocorticoids act synergistically with polycyclic aromatic hydrocarbons in increasing mRNA and protein levels of CYP1A1 in rat liver. Polycyclic Aromatic Hydrocarbons 41-73 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 115-121 15794642-1 2005 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known to mediate the toxic effects of numerous environmental contaminants, including the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 168-200 aryl hydrocarbon receptor Homo sapiens 4-29 15794642-1 2005 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known to mediate the toxic effects of numerous environmental contaminants, including the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 168-200 aryl hydrocarbon receptor Homo sapiens 31-34 15794642-1 2005 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known to mediate the toxic effects of numerous environmental contaminants, including the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 202-206 aryl hydrocarbon receptor Homo sapiens 4-29 15794642-1 2005 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known to mediate the toxic effects of numerous environmental contaminants, including the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 202-206 aryl hydrocarbon receptor Homo sapiens 31-34 16101325-2 2005 Major polycyclic aromatic hydrocarbons (PAHs) included in the extracts of airborne particles were investigated for their mutagenicity and potential for inducing drug-metabolizing enzyme cytochrome P450 (CYP)1A1, which is considered to be responsible for the activation of PAHs in airborne particle extracts, as well as in cigarette smoke, to carcinogens and is associated with risk of several cancers. Polycyclic Aromatic Hydrocarbons 6-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 186-210 16101325-2 2005 Major polycyclic aromatic hydrocarbons (PAHs) included in the extracts of airborne particles were investigated for their mutagenicity and potential for inducing drug-metabolizing enzyme cytochrome P450 (CYP)1A1, which is considered to be responsible for the activation of PAHs in airborne particle extracts, as well as in cigarette smoke, to carcinogens and is associated with risk of several cancers. Polycyclic Aromatic Hydrocarbons 40-44 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 186-210 16101325-2 2005 Major polycyclic aromatic hydrocarbons (PAHs) included in the extracts of airborne particles were investigated for their mutagenicity and potential for inducing drug-metabolizing enzyme cytochrome P450 (CYP)1A1, which is considered to be responsible for the activation of PAHs in airborne particle extracts, as well as in cigarette smoke, to carcinogens and is associated with risk of several cancers. Polycyclic Aromatic Hydrocarbons 272-276 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 186-210 16101325-3 2005 There was a dose-related increase in CYP1A1 activity in human lymphoblastoid cells after exposure to airborne particulates containing PAHs. Polycyclic Aromatic Hydrocarbons 134-138 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 37-43 15833025-1 2005 The polycyclic aromatic hydrocarbons (PAHs) dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) are widespread environmental contaminants and potent carcinogens. Polycyclic Aromatic Hydrocarbons 4-36 D-box binding PAR bZIP transcription factor Homo sapiens 64-67 15833025-1 2005 The polycyclic aromatic hydrocarbons (PAHs) dibenzo[a,l]pyrene (DBP) and benzo[a]pyrene (BP) are widespread environmental contaminants and potent carcinogens. Polycyclic Aromatic Hydrocarbons 38-42 D-box binding PAR bZIP transcription factor Homo sapiens 64-67 15792794-1 2005 Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are toxic environmental contaminants known to enhance production of pro-inflammatory cytokines such as IL-1beta. Polycyclic Aromatic Hydrocarbons 0-32 interleukin 1 beta Homo sapiens 171-179 15792794-1 2005 Polycyclic aromatic hydrocarbons (PAHs) such as benzo(a)pyrene (BP) are toxic environmental contaminants known to enhance production of pro-inflammatory cytokines such as IL-1beta. Polycyclic Aromatic Hydrocarbons 34-38 interleukin 1 beta Homo sapiens 171-179 15832810-5 2005 For instance, the expression of CYP1 genes can be induced by AhR, which dimerizes with the AhR nuclear translocator (Arnt), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 144-175 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-36 15832810-5 2005 For instance, the expression of CYP1 genes can be induced by AhR, which dimerizes with the AhR nuclear translocator (Arnt), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 144-175 aryl hydrocarbon receptor Homo sapiens 61-64 15832810-5 2005 For instance, the expression of CYP1 genes can be induced by AhR, which dimerizes with the AhR nuclear translocator (Arnt), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 144-175 aryl hydrocarbon receptor nuclear translocator Homo sapiens 91-115 15832810-5 2005 For instance, the expression of CYP1 genes can be induced by AhR, which dimerizes with the AhR nuclear translocator (Arnt), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 144-175 aryl hydrocarbon receptor nuclear translocator Homo sapiens 117-121 15832810-5 2005 For instance, the expression of CYP1 genes can be induced by AhR, which dimerizes with the AhR nuclear translocator (Arnt), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 177-181 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-36 15832810-5 2005 For instance, the expression of CYP1 genes can be induced by AhR, which dimerizes with the AhR nuclear translocator (Arnt), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 177-181 aryl hydrocarbon receptor Homo sapiens 61-64 15832810-5 2005 For instance, the expression of CYP1 genes can be induced by AhR, which dimerizes with the AhR nuclear translocator (Arnt), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 177-181 aryl hydrocarbon receptor nuclear translocator Homo sapiens 91-115 15832810-5 2005 For instance, the expression of CYP1 genes can be induced by AhR, which dimerizes with the AhR nuclear translocator (Arnt), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 177-181 aryl hydrocarbon receptor nuclear translocator Homo sapiens 117-121 16004327-1 2005 The effect of anionic surfactant LAS on leaching of PAHs from artificially contaminated soil was studied. Polycyclic Aromatic Hydrocarbons 52-56 lipoic acid synthetase Homo sapiens 33-36 15824912-1 2005 OBJECTIVE: Polycyclic aromatic hydrocarbons in cigarette smoke induce cytochrome P450(CYP)1A2, which is involved in the hepatic metabolism of melatonin (MT). Polycyclic Aromatic Hydrocarbons 11-43 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 70-93 15830838-4 2005 Polycyclic aromatic hydrocarbons are toxic environmental pollutants, which indirectly act as anti-estrogens by activating the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 126-151 15830838-4 2005 Polycyclic aromatic hydrocarbons are toxic environmental pollutants, which indirectly act as anti-estrogens by activating the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 153-156 15740759-0 2005 Crop-specific human exposure assessment for polycyclic aromatic hydrocarbons in Czech soils. Polycyclic Aromatic Hydrocarbons 44-76 LUC7 like 3 pre-mRNA splicing factor Homo sapiens 0-4 15740759-8 2005 A virtually safe oral dose of BaP, as a marker of the carcinogenic PAH, was suggested by a European expert commission to be below 4.2 to 35 ng per person and day. Polycyclic Aromatic Hydrocarbons 67-70 prohibitin 2 Homo sapiens 30-33 15688157-7 2005 Values of the PAH in TSP, PM10, PM2.5 and PM1 were assessed. Polycyclic Aromatic Hydrocarbons 14-17 thrombospondin 1 Homo sapiens 21-24 15564291-2 2005 Previous studies of lung tumors from both non-smoking women and smoking men in this region showed high frequencies of mutations, consisting mostly of G-->T transversions in the p53 tumor suppressor gene and K-ras oncogene, suggesting that these mutations were caused primarily by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 283-315 tumor protein p53 Homo sapiens 180-183 15734955-3 2005 Using the Long Island Breast Cancer Study Project, a population-based case-control study, we evaluated the hypothesis that two common single nucleotide polymorphisms of XRCC1 (codon 194 Arg-->Trp and 399 Arg-->Gln) influence breast cancer susceptibility and interact with polycyclic aromatic hydrocarbon (PAH)-DNA adducts, cigarette smoking, and intake of fruits and vegetables and antioxidants. Polycyclic Aromatic Hydrocarbons 278-309 X-ray repair cross complementing 1 Homo sapiens 169-174 15734955-3 2005 Using the Long Island Breast Cancer Study Project, a population-based case-control study, we evaluated the hypothesis that two common single nucleotide polymorphisms of XRCC1 (codon 194 Arg-->Trp and 399 Arg-->Gln) influence breast cancer susceptibility and interact with polycyclic aromatic hydrocarbon (PAH)-DNA adducts, cigarette smoking, and intake of fruits and vegetables and antioxidants. Polycyclic Aromatic Hydrocarbons 311-314 X-ray repair cross complementing 1 Homo sapiens 169-174 15734955-13 2005 Further understanding of the biological function of XRCC1 variants and their interactions with PAH-DNA adducts, antioxidants, and other genes in the pathway are needed. Polycyclic Aromatic Hydrocarbons 95-98 X-ray repair cross complementing 1 Homo sapiens 52-57 15671210-1 2005 We hypothesized that the risk of colorectal cancer associated with meat preparation methods producing heterocyclic amines or polycyclic aromatic hydrocarbons is modified by the CYP1A1 genotype alone or in combination with the GSTM1 genotype or the NAT2 imputed phenotype. Polycyclic Aromatic Hydrocarbons 125-157 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 177-183 15671210-1 2005 We hypothesized that the risk of colorectal cancer associated with meat preparation methods producing heterocyclic amines or polycyclic aromatic hydrocarbons is modified by the CYP1A1 genotype alone or in combination with the GSTM1 genotype or the NAT2 imputed phenotype. Polycyclic Aromatic Hydrocarbons 125-157 N-acetyltransferase 2 Homo sapiens 248-252 15548639-1 2005 Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (BaP), are carcinogens suggested to be involved in development of human cancer. Polycyclic Aromatic Hydrocarbons 0-32 prohibitin 2 Homo sapiens 65-68 15548639-1 2005 Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (BaP), are carcinogens suggested to be involved in development of human cancer. Polycyclic Aromatic Hydrocarbons 34-38 prohibitin 2 Homo sapiens 65-68 15548639-4 2005 In the present study, we found that two PAHs, benz[a]anthracene (BaA) and BaP, can stimulate proliferation of human breast carcinoma MCF-7 cells at concentrations 100 nM and higher. Polycyclic Aromatic Hydrocarbons 40-44 prohibitin 2 Homo sapiens 74-77 15581594-1 2005 The aryl hydrocarbon receptor (AHR) mediates the carcinogenic and other toxic effects of a variety of environmental pollutants, including 2,37,8-tetrachlorodibenzo-p-dioxin (TCDD), and some polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 190-222 aryl hydrocarbon receptor Homo sapiens 4-29 15581594-1 2005 The aryl hydrocarbon receptor (AHR) mediates the carcinogenic and other toxic effects of a variety of environmental pollutants, including 2,37,8-tetrachlorodibenzo-p-dioxin (TCDD), and some polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 190-222 aryl hydrocarbon receptor Homo sapiens 31-34 15581594-1 2005 The aryl hydrocarbon receptor (AHR) mediates the carcinogenic and other toxic effects of a variety of environmental pollutants, including 2,37,8-tetrachlorodibenzo-p-dioxin (TCDD), and some polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 224-228 aryl hydrocarbon receptor Homo sapiens 4-29 15581594-1 2005 The aryl hydrocarbon receptor (AHR) mediates the carcinogenic and other toxic effects of a variety of environmental pollutants, including 2,37,8-tetrachlorodibenzo-p-dioxin (TCDD), and some polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 224-228 aryl hydrocarbon receptor Homo sapiens 31-34 15581594-4 2005 However, induction of Cyp1a1 is known to represent a significant event in the toxicity of PAHs. Polycyclic Aromatic Hydrocarbons 90-94 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 22-28 15740184-2 2005 The binding energy of PAH clusters ranging in size from the benzene dimer to the pyrene dimer obtained by ab initio calculations at the MP2 level was used to extract the pair potentials in the form of the Lennard-Jones and Exponential-6 functions. Polycyclic Aromatic Hydrocarbons 22-25 tryptase pseudogene 1 Homo sapiens 136-139 15816606-2 2005 MATERIALS AND METHODS: To investigate the role of polycyclic aromatic hydrocarbons (PAHs) in the etiology of ESCC in northeastern Iran, we measured urine 1-hydroxypyrene glucuronide (1-OHPG), a stable PAH metabolite, in 99 inhabitants of this area. Polycyclic Aromatic Hydrocarbons 50-82 phenylalanine hydroxylase Homo sapiens 84-87 15743503-1 2005 INTRODUCTION: Sulfotransferase 1A1 (encoded by SULT1A1) is involved in the metabolism of procarcinogens such as heterocyclic amines and polycyclic aromatic hydrocarbons, both of which are present in tobacco smoke. Polycyclic Aromatic Hydrocarbons 136-168 sulfotransferase family 1A member 1 Homo sapiens 47-54 16097393-5 2005 Catalase activity (CAT) and lipid oxidation (evaluated as malonedialdehyde) are markers of oxidative stress, glutathione S-transferase (GST) activity is related to conjugation of organic compounds and benzo(a)pyrene hydroxylase activity (BPH) is a marker of effect of certain planar organic compounds (e.g. polycyclic aromatic hydrocarbons, PAHs). Polycyclic Aromatic Hydrocarbons 307-339 glutathione S-transferase kappa 1 Homo sapiens 109-134 16097393-5 2005 Catalase activity (CAT) and lipid oxidation (evaluated as malonedialdehyde) are markers of oxidative stress, glutathione S-transferase (GST) activity is related to conjugation of organic compounds and benzo(a)pyrene hydroxylase activity (BPH) is a marker of effect of certain planar organic compounds (e.g. polycyclic aromatic hydrocarbons, PAHs). Polycyclic Aromatic Hydrocarbons 307-339 glutathione S-transferase kappa 1 Homo sapiens 136-139 16097393-5 2005 Catalase activity (CAT) and lipid oxidation (evaluated as malonedialdehyde) are markers of oxidative stress, glutathione S-transferase (GST) activity is related to conjugation of organic compounds and benzo(a)pyrene hydroxylase activity (BPH) is a marker of effect of certain planar organic compounds (e.g. polycyclic aromatic hydrocarbons, PAHs). Polycyclic Aromatic Hydrocarbons 341-345 glutathione S-transferase kappa 1 Homo sapiens 109-134 16097393-5 2005 Catalase activity (CAT) and lipid oxidation (evaluated as malonedialdehyde) are markers of oxidative stress, glutathione S-transferase (GST) activity is related to conjugation of organic compounds and benzo(a)pyrene hydroxylase activity (BPH) is a marker of effect of certain planar organic compounds (e.g. polycyclic aromatic hydrocarbons, PAHs). Polycyclic Aromatic Hydrocarbons 341-345 glutathione S-transferase kappa 1 Homo sapiens 136-139 15668489-2 2005 Microsomal epoxide hydrolase (EPHX1) metabolizes polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 49-81 epoxide hydrolase 1 Homo sapiens 0-28 15668489-2 2005 Microsomal epoxide hydrolase (EPHX1) metabolizes polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 49-81 epoxide hydrolase 1 Homo sapiens 30-35 15626640-10 2005 Moreover, because PAH toxicity is also linked to estrogenicity of the compounds, the PAH bioactivation potency of colon microbiota suggests that current risk assessment may underestimate the risk from ingested PAHs. Polycyclic Aromatic Hydrocarbons 210-214 phenylalanine hydroxylase Homo sapiens 85-88 15667070-4 2005 Light produced by the extracts is a function of the concentrations and potencies of those compounds with an affinity for Ah-receptor (certain polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and dioxins/ furans). Polycyclic Aromatic Hydrocarbons 142-174 aryl hydrocarbon receptor Homo sapiens 121-132 15915151-2 2005 The CYP1 family is of particular interest in environmental toxicology because its members are dominant in the metabolism of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and aryl amines. Polycyclic Aromatic Hydrocarbons 124-156 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 15915151-2 2005 The CYP1 family is of particular interest in environmental toxicology because its members are dominant in the metabolism of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and aryl amines. Polycyclic Aromatic Hydrocarbons 158-162 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 16312996-2 2005 Accelerated solvent extraction(ASE) was used to extract PAHs from sediments with satisfactory recoveries. Polycyclic Aromatic Hydrocarbons 56-60 arylsulfatase L Homo sapiens 31-34 15604244-5 2004 Variables significantly associated with PAH-DNA adduct levels in tumor cells included primary Gleason grade, tumor volume, and log-transformed prostate-specific antigen (PSA) at time of diagnosis. Polycyclic Aromatic Hydrocarbons 40-43 kallikrein related peptidase 3 Homo sapiens 143-174 15464628-4 2004 Organic pollutants influence the expression profile of cytochromes P450 (CYP), and CYP1A1 has been shown to be a suitable biomarker for polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 136-168 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 83-89 15464628-4 2004 Organic pollutants influence the expression profile of cytochromes P450 (CYP), and CYP1A1 has been shown to be a suitable biomarker for polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 170-173 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 83-89 15464628-6 2004 Upon intake of PAH-contaminated soils, CYP1A1 is induced in various organs of rats and minipigs. Polycyclic Aromatic Hydrocarbons 15-18 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 39-45 15581363-1 2004 The arylhydrocarbon receptor (AhR) functions as a ligand-activated transcription factor that regulates the transcription of genes encoding xenobiotic metabolizing enzymes and also mediates most of the toxic effects caused by dioxins and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 237-269 aryl hydrocarbon receptor Homo sapiens 4-28 15581363-1 2004 The arylhydrocarbon receptor (AhR) functions as a ligand-activated transcription factor that regulates the transcription of genes encoding xenobiotic metabolizing enzymes and also mediates most of the toxic effects caused by dioxins and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 237-269 aryl hydrocarbon receptor Homo sapiens 30-33 15582647-5 2004 In addition, we demonstrate for the first time the induction of Cyp1b1 RNA expression in fetal lung and liver tissues following in utero exposure to 3-methylcholanthrene (MC), a polycyclic aromatic hydrocarbon. Polycyclic Aromatic Hydrocarbons 178-209 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 64-70 15650250-2 2004 Depurinating DNA adducts of polycyclic aromatic hydrocarbons play a major role in the initiation of cancer, as shown by the correlation between depurinating adducts and oncogenic mutations of the H-ras oncogene in mouse skin. Polycyclic Aromatic Hydrocarbons 28-60 Harvey rat sarcoma virus oncogene Mus musculus 196-201 15606950-0 2004 C18-modified metal-colloid substrates for surface-enhanced Raman detection of trace-level polycyclic aromatic hydrocarbons in aqueous solution. Polycyclic Aromatic Hydrocarbons 90-122 Bardet-Biedl syndrome 9 Homo sapiens 0-3 15606950-1 2004 Metal colloids immobilized on a glass support substrate are modified with a self-assembled alkylsilane (C18) layer to promote adsorption of polycyclic aromatic hydrocarbons from aqueous solutions. Polycyclic Aromatic Hydrocarbons 140-172 Bardet-Biedl syndrome 9 Homo sapiens 104-107 15801491-10 2004 This finding is consistent with previous studies suggesting that substrates for the cytochrome P-450 1A1 metabolic pathway, such as polycyclic aromatic hydrocarbons, may be etiologically significant in this high-risk region. Polycyclic Aromatic Hydrocarbons 132-164 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 84-104 15606143-3 2004 We therefore investigated the formation of PAH-DNA adducts in the epidermis of Cyp1a2(-/-), Cyp1b1(-/-), and Ahr(-/-) knockout mice. Polycyclic Aromatic Hydrocarbons 43-46 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 79-85 15579409-7 2004 In contrast, embryos coexposed to the PAHs with each of the CYP1A inhibitors tested were deformed with increased severity and frequency compared with embryos dosed with PAH alone. Polycyclic Aromatic Hydrocarbons 38-41 cytochrome P450 1A1 Fundulus heteroclitus 60-65 15579409-8 2004 The mechanism by which inhibition of CYP1A increased embryotoxicity of the PAHs tested is not understood, but these results may be helpful in elucidating mechanisms by which PAHs are embryotoxic. Polycyclic Aromatic Hydrocarbons 75-79 cytochrome P450 1A1 Fundulus heteroclitus 37-42 15342960-4 2004 The following experiments were conducted to determine if EGR1 is indeed a target of TCDD and polycyclic aromatic hydrocarbons (PAHs) that can act through a similar mechanism. Polycyclic Aromatic Hydrocarbons 93-125 early growth response 1 Homo sapiens 57-61 15342960-4 2004 The following experiments were conducted to determine if EGR1 is indeed a target of TCDD and polycyclic aromatic hydrocarbons (PAHs) that can act through a similar mechanism. Polycyclic Aromatic Hydrocarbons 127-131 early growth response 1 Homo sapiens 57-61 15342960-9 2004 Thus, the increase in EGR1 expression appears to be mediated through a post-transcriptional mechanism that leads to the higher EGR1 protein levels in TCDD and PAH treated cells, compared to vehicle treated cells. Polycyclic Aromatic Hydrocarbons 159-162 early growth response 1 Homo sapiens 22-26 15342960-9 2004 Thus, the increase in EGR1 expression appears to be mediated through a post-transcriptional mechanism that leads to the higher EGR1 protein levels in TCDD and PAH treated cells, compared to vehicle treated cells. Polycyclic Aromatic Hydrocarbons 159-162 early growth response 1 Homo sapiens 127-131 15566942-6 2004 The gene expression of the Phase II enzymes UDP-glucuronosyltransferase 1A6 (UGT1A6) and UGT1A7 was also induced by these PAH but treatment with them had no effect on gene expression of sulfotransferases (SULT) at all. Polycyclic Aromatic Hydrocarbons 122-125 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 44-75 15566942-6 2004 The gene expression of the Phase II enzymes UDP-glucuronosyltransferase 1A6 (UGT1A6) and UGT1A7 was also induced by these PAH but treatment with them had no effect on gene expression of sulfotransferases (SULT) at all. Polycyclic Aromatic Hydrocarbons 122-125 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 77-83 15566942-6 2004 The gene expression of the Phase II enzymes UDP-glucuronosyltransferase 1A6 (UGT1A6) and UGT1A7 was also induced by these PAH but treatment with them had no effect on gene expression of sulfotransferases (SULT) at all. Polycyclic Aromatic Hydrocarbons 122-125 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 89-95 15566942-7 2004 Of the ABC-transport proteins, MDR1 mRNA expression was induced by treatment with carcinogenic PAH, whereas MRP2 mRNA expression was not changed. Polycyclic Aromatic Hydrocarbons 95-98 ATP binding cassette subfamily B member 1 Homo sapiens 31-35 15566942-8 2004 The mixture of PAH also induced CYP1A1, CYP1B1, UGT1A6, and UGT1A7 mRNA expression. Polycyclic Aromatic Hydrocarbons 15-18 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-38 15566942-8 2004 The mixture of PAH also induced CYP1A1, CYP1B1, UGT1A6, and UGT1A7 mRNA expression. Polycyclic Aromatic Hydrocarbons 15-18 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 40-46 15566942-8 2004 The mixture of PAH also induced CYP1A1, CYP1B1, UGT1A6, and UGT1A7 mRNA expression. Polycyclic Aromatic Hydrocarbons 15-18 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 48-54 15566942-8 2004 The mixture of PAH also induced CYP1A1, CYP1B1, UGT1A6, and UGT1A7 mRNA expression. Polycyclic Aromatic Hydrocarbons 15-18 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 60-66 15496536-1 2004 Cytochrome P-450 (CYP) is involved in the activation and metabolism of polycyclic aromatic hydrocarbons in tobacco products. Polycyclic Aromatic Hydrocarbons 71-103 uncharacterized protein LOC107819388 Nicotiana tabacum 0-16 15496536-1 2004 Cytochrome P-450 (CYP) is involved in the activation and metabolism of polycyclic aromatic hydrocarbons in tobacco products. Polycyclic Aromatic Hydrocarbons 71-103 uncharacterized protein LOC107819388 Nicotiana tabacum 18-21 15284179-0 2004 Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions. Polycyclic Aromatic Hydrocarbons 97-100 aldo-keto reductase family 1 member C3 Homo sapiens 31-37 15284179-0 2004 Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions. Polycyclic Aromatic Hydrocarbons 97-100 8-oxoguanine DNA glycosylase Homo sapiens 42-46 15297370-5 2004 These findings are consistent with prior evidence that polycyclic aromatic hydrocarbons, known ligands of the AhR, stimulate CYP1B1 transcription by an XRE-dependent mechanism. Polycyclic Aromatic Hydrocarbons 55-87 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 125-131 15521013-1 2004 BACKGROUND AND AIMS: Cytochrome P450 1A1 catalyzes the degradation of endobiotics (estradiol, fatty acids, and so on) and the bioactivation of numerous environmental procarcinogens, such as arylamines and polycyclic aromatic hydrocarbons, that are found in food. Polycyclic Aromatic Hydrocarbons 205-237 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-40 15352028-2 2004 Although the carcinogenicity of PAH may be primarily mediated by the aryl hydrocarbon receptor (AhR), the in vivo role of AhR in skin carcinogenesis remains to be defined. Polycyclic Aromatic Hydrocarbons 32-35 aryl-hydrocarbon receptor Mus musculus 69-94 15352028-2 2004 Although the carcinogenicity of PAH may be primarily mediated by the aryl hydrocarbon receptor (AhR), the in vivo role of AhR in skin carcinogenesis remains to be defined. Polycyclic Aromatic Hydrocarbons 32-35 aryl-hydrocarbon receptor Mus musculus 96-99 15604244-8 2004 PSA levels were inversely associated with PAH-DNA adduct levels in tumor cells (P = 0.009). Polycyclic Aromatic Hydrocarbons 42-45 kallikrein related peptidase 3 Homo sapiens 0-3 15604244-9 2004 A similar, albeit less significant, inverse association was observed between PSA and PAH-DNA adduct levels in nontumor cells (P = 0.07). Polycyclic Aromatic Hydrocarbons 85-88 kallikrein related peptidase 3 Homo sapiens 77-80 15301869-0 2004 Role of estrogen receptor in regulation of polycyclic aromatic hydrocarbon metabolic activation in lung. Polycyclic Aromatic Hydrocarbons 43-74 estrogen receptor 1 Homo sapiens 8-25 15466980-2 2004 Cytochrome P450, glutathione S-transferase, microsomal epoxide hydrolase, NAD(P)H:quinone oxidoreductase, and N-acetyltransferase are PAH-metabolizing enzymes. Polycyclic Aromatic Hydrocarbons 134-137 glutathione S-transferase kappa 1 Homo sapiens 17-42 15466980-2 2004 Cytochrome P450, glutathione S-transferase, microsomal epoxide hydrolase, NAD(P)H:quinone oxidoreductase, and N-acetyltransferase are PAH-metabolizing enzymes. Polycyclic Aromatic Hydrocarbons 134-137 epoxide hydrolase 1 Homo sapiens 44-72 15466980-7 2004 Gene-environment interactions between occupational PAH exposure and polymorphisms of mEH and/or GSTM1 were also evident. Polycyclic Aromatic Hydrocarbons 51-54 epoxide hydrolase 1, microsomal Mus musculus 85-88 15466980-7 2004 Gene-environment interactions between occupational PAH exposure and polymorphisms of mEH and/or GSTM1 were also evident. Polycyclic Aromatic Hydrocarbons 51-54 glutathione S-transferase mu 1 Homo sapiens 96-101 15466980-8 2004 These results indicate that the mEH, GSTP1, and GSTM1 polymorphisms may play a role in sensitivity or genetic susceptibility to the genotoxic effects of PAH exposure in the coke-oven workers. Polycyclic Aromatic Hydrocarbons 153-156 epoxide hydrolase 1, microsomal Mus musculus 32-35 15466980-8 2004 These results indicate that the mEH, GSTP1, and GSTM1 polymorphisms may play a role in sensitivity or genetic susceptibility to the genotoxic effects of PAH exposure in the coke-oven workers. Polycyclic Aromatic Hydrocarbons 153-156 glutathione S-transferase pi 1 Homo sapiens 37-42 15466980-8 2004 These results indicate that the mEH, GSTP1, and GSTM1 polymorphisms may play a role in sensitivity or genetic susceptibility to the genotoxic effects of PAH exposure in the coke-oven workers. Polycyclic Aromatic Hydrocarbons 153-156 glutathione S-transferase mu 1 Homo sapiens 48-53 15308241-9 2004 The developed SPR sensor for HBP is free from interference by coexisting benzo[a]pyrene (BaP), 2,4-dichlorophenoxyacetic acid (2,4-D) and benz[a]anthracene; SPR angle shift obtained to the flow of HBP is almost same irrespective to the presence or absence of a same concentration of these carcinogenic polycyclic aromatic hydrocarbons together. Polycyclic Aromatic Hydrocarbons 302-334 heme binding protein 1 Homo sapiens 29-32 15519522-5 2004 The possible modifying effect on MBC risk in subjects carrying BRCA1/2 germ-line mutations of an occupation characterised by exposure to chemicals such as polycyclic aromatic hydrocarbons (PAH) that are capable of inducing DNA damage, may provide clues to the role of environmental exposures in modifying BC risk in mutation carriers in both genders. Polycyclic Aromatic Hydrocarbons 155-187 BRCA1 DNA repair associated Homo sapiens 63-70 15519522-5 2004 The possible modifying effect on MBC risk in subjects carrying BRCA1/2 germ-line mutations of an occupation characterised by exposure to chemicals such as polycyclic aromatic hydrocarbons (PAH) that are capable of inducing DNA damage, may provide clues to the role of environmental exposures in modifying BC risk in mutation carriers in both genders. Polycyclic Aromatic Hydrocarbons 189-192 BRCA1 DNA repair associated Homo sapiens 63-70 15580705-1 2004 The cytochrome P450 CYP1B1 enzyme metabolically activates polycyclic aromatic hydrocarbons and is a major P450 isoenzyme in human monocytes and macrophages. Polycyclic Aromatic Hydrocarbons 58-90 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 20-26 15569511-10 2004 CONCLUSION: Plasma level of 1,2-NPQ-Alb could effectively reflect their magnitude of personal internal dose of exposure to air PAH, so it could be used as a potential biomarker to evaluate their intermediate/long-term exposure to PAH in coke oven workers. Polycyclic Aromatic Hydrocarbons 127-130 albumin Homo sapiens 36-39 15569511-10 2004 CONCLUSION: Plasma level of 1,2-NPQ-Alb could effectively reflect their magnitude of personal internal dose of exposure to air PAH, so it could be used as a potential biomarker to evaluate their intermediate/long-term exposure to PAH in coke oven workers. Polycyclic Aromatic Hydrocarbons 230-233 albumin Homo sapiens 36-39 15511094-0 2004 Adsorption of polycyclic aromatic hydrocarbons at the air-water interface and its role in atmospheric deposition by fog droplets. Polycyclic Aromatic Hydrocarbons 14-46 zinc finger protein, FOG family member 1 Homo sapiens 116-119 15511094-1 2004 This review addresses the significance of air-water interfacial adsorption in the fate and transport of polycyclic aromatic hydrocarbons (PAHs) in dispersed systems, such as fog droplets in the atmosphere and air bubbles in wastewater systems. Polycyclic Aromatic Hydrocarbons 104-136 zinc finger protein, FOG family member 1 Homo sapiens 174-177 15511094-1 2004 This review addresses the significance of air-water interfacial adsorption in the fate and transport of polycyclic aromatic hydrocarbons (PAHs) in dispersed systems, such as fog droplets in the atmosphere and air bubbles in wastewater systems. Polycyclic Aromatic Hydrocarbons 138-142 zinc finger protein, FOG family member 1 Homo sapiens 174-177 15584438-2 2004 Genetic polymorphisms which influence biomarkers (urinary metabolites, protein and DNA adducts), include P450 cytochromes (CYPs) and glutathione S-transferases (GSTs) in exposure to polycyclic aromatic hydrocarbons (PAHs), and acetyltransferases (NATs) in exposure to aromatic amines (AAs). Polycyclic Aromatic Hydrocarbons 182-214 glutathione S-transferase mu 1 Homo sapiens 161-165 15584438-2 2004 Genetic polymorphisms which influence biomarkers (urinary metabolites, protein and DNA adducts), include P450 cytochromes (CYPs) and glutathione S-transferases (GSTs) in exposure to polycyclic aromatic hydrocarbons (PAHs), and acetyltransferases (NATs) in exposure to aromatic amines (AAs). Polycyclic Aromatic Hydrocarbons 216-220 glutathione S-transferase mu 1 Homo sapiens 161-165 15584438-7 2004 Almost all studies show the clearcut influence (i.e., increased lung cancer risk with OR > or = 2) of genetic polymorphisms linked to PAH metabolism (in particular, CYPIA1, GSTM1 and P1). Polycyclic Aromatic Hydrocarbons 137-140 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 168-174 15584438-7 2004 Almost all studies show the clearcut influence (i.e., increased lung cancer risk with OR > or = 2) of genetic polymorphisms linked to PAH metabolism (in particular, CYPIA1, GSTM1 and P1). Polycyclic Aromatic Hydrocarbons 137-140 glutathione S-transferase mu 1 Homo sapiens 176-181 15563282-2 2004 Because compounds with the highest toxicity, such as dibenz(a,h)anthracene and benzo(a)pyrene (BAP), also tended to be the least rapidly and least extensively desorbed, the U.S. Environmental Protection Agency (EPA) default guidance may dramatically overestimate risk from exposure to PAH-contaminated soils or sediments. Polycyclic Aromatic Hydrocarbons 285-288 prohibitin 2 Homo sapiens 95-98 15364538-1 2004 Cytochromes P450 1A1 and 1B1 are known to bioactivate procarcinogens such as polycyclic aromatic hydrocarbons (PAHs) found in cigarette smoke and are inducible via an Ah receptor-mediated mechanism. Polycyclic Aromatic Hydrocarbons 77-109 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 12-28 15364538-1 2004 Cytochromes P450 1A1 and 1B1 are known to bioactivate procarcinogens such as polycyclic aromatic hydrocarbons (PAHs) found in cigarette smoke and are inducible via an Ah receptor-mediated mechanism. Polycyclic Aromatic Hydrocarbons 111-115 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 12-28 15471096-0 2004 Occupational exposure to polycyclic aromatic hydrocarbons suppresses constitutive expression of CYP1B1 on the transcript level in human leukocytes. Polycyclic Aromatic Hydrocarbons 25-57 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 96-102 15471096-1 2004 Expression patterns of the cytochromes P450 CYP1A1 and CYP1B1 have been analyzed on the transcript level in leukocytes of persons (n = 30) occupationally exposed to polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 165-197 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 15471096-1 2004 Expression patterns of the cytochromes P450 CYP1A1 and CYP1B1 have been analyzed on the transcript level in leukocytes of persons (n = 30) occupationally exposed to polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 165-197 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 55-61 15471096-1 2004 Expression patterns of the cytochromes P450 CYP1A1 and CYP1B1 have been analyzed on the transcript level in leukocytes of persons (n = 30) occupationally exposed to polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 199-202 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 44-50 15471096-1 2004 Expression patterns of the cytochromes P450 CYP1A1 and CYP1B1 have been analyzed on the transcript level in leukocytes of persons (n = 30) occupationally exposed to polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 199-202 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 55-61 15471096-7 2004 People involved in graphite electrode production and exposed to PAH show largely decreased CYP1B1 transcript levels. Polycyclic Aromatic Hydrocarbons 64-67 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 91-97 15322212-5 2004 We demonstrate that aromatic and polar DEP fractions, which are enriched in polycyclic aromatic hydrocarbons and quinones, respectively, induce the expression of HO-1, GST, and other phase II enzymes in macrophages and epithelial cells. Polycyclic Aromatic Hydrocarbons 76-108 heme oxygenase 1 Homo sapiens 162-166 15742974-0 2004 Different mechanisms of handling ingested polycyclic aromatic hydrocarbons in mammalian species: organ-specific response patterns of CYP1A1-induction after oral intake of PAH-contaminated soils. Polycyclic Aromatic Hydrocarbons 42-74 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 133-139 15315710-0 2004 Inducible cytochrome P450 activities in renal glomerular mesangial cells: biochemical basis for antagonistic interactions among nephrocarcinogenic polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 147-179 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 10-25 15315710-1 2004 BACKGROUND: Benzo(a)pyrene (BaP), anthracene (ANTH) and chrysene (CHRY) are polynuclear aromatic hydrocarbons (PAHs) implicated in renal toxicity and carcinogenesis. Polycyclic Aromatic Hydrocarbons 76-109 prohibitin 2 Homo sapiens 28-31 15315710-1 2004 BACKGROUND: Benzo(a)pyrene (BaP), anthracene (ANTH) and chrysene (CHRY) are polynuclear aromatic hydrocarbons (PAHs) implicated in renal toxicity and carcinogenesis. Polycyclic Aromatic Hydrocarbons 111-115 prohibitin 2 Homo sapiens 28-31 15279838-1 2004 We newly developed 10 Salmonela typhimurium TA1538 strains each co-expressing a form of human cytochrome P450s (P450 or CYP) together with NADPH-cytochrome P450 reductase (CPR) for highly sensitive detection of mutagenic activation of mycotoxins, polycyclic aromatic hydrocarbons, heterocyclic amines, and aromatic amines at low substrate concentrations. Polycyclic Aromatic Hydrocarbons 247-279 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 94-123 15274625-1 2004 The ultimate diol epoxide carcinogens derived from polycyclic aromatic hydrocarbons, such as benzo[a]pyrene (BP), are metabolized primarily by glutathione (GSH) conjugation reaction catalyzed by GSH transferases (GSTs). Polycyclic Aromatic Hydrocarbons 51-83 glutathione S-transferase alpha 1 Homo sapiens 213-217 15072980-1 2004 Cytochrome P4501A1 (CYP1A1) metabolizes polycyclic aromatic hydrocarbons in cigarette smoke to DNA-binding reactive intermediates associated with carcinogenesis. Polycyclic Aromatic Hydrocarbons 40-72 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 0-18 15072980-1 2004 Cytochrome P4501A1 (CYP1A1) metabolizes polycyclic aromatic hydrocarbons in cigarette smoke to DNA-binding reactive intermediates associated with carcinogenesis. Polycyclic Aromatic Hydrocarbons 40-72 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 20-26 15290664-2 2004 The cytochrome P-450 (CYP) 2C9 (CYP2C9) enzyme is involved in the metabolism of several drugs, including possibly aspirin, and such carcinogens as smoking-related polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 163-195 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 4-30 15290664-2 2004 The cytochrome P-450 (CYP) 2C9 (CYP2C9) enzyme is involved in the metabolism of several drugs, including possibly aspirin, and such carcinogens as smoking-related polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 163-195 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 32-38 15258110-1 2004 The cytochrome P450 family 1 (CYP1) is considered to be one of the xenobiotic-metabolizing enzyme families and is responsible for oxidative metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 154-186 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 4-28 15258110-1 2004 The cytochrome P450 family 1 (CYP1) is considered to be one of the xenobiotic-metabolizing enzyme families and is responsible for oxidative metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 154-186 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 30-34 15742974-0 2004 Different mechanisms of handling ingested polycyclic aromatic hydrocarbons in mammalian species: organ-specific response patterns of CYP1A1-induction after oral intake of PAH-contaminated soils. Polycyclic Aromatic Hydrocarbons 171-174 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 133-139 15742974-3 2004 We analysed the basal expression of cytochrome P450 (CYP) enzymes in several organs of minipigs and rats, and their inducibility upon oral intake of soils containing polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 166-198 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 36-51 15742974-3 2004 We analysed the basal expression of cytochrome P450 (CYP) enzymes in several organs of minipigs and rats, and their inducibility upon oral intake of soils containing polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 166-198 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 53-56 15742974-3 2004 We analysed the basal expression of cytochrome P450 (CYP) enzymes in several organs of minipigs and rats, and their inducibility upon oral intake of soils containing polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 200-203 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 36-51 15742974-3 2004 We analysed the basal expression of cytochrome P450 (CYP) enzymes in several organs of minipigs and rats, and their inducibility upon oral intake of soils containing polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 200-203 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 53-56 15742974-5 2004 Upon ingestion of PAH-contaminated soils, CYP1A1 is differentially induced in a tissue-specific and dose-dependent manner in duodenum, liver and kidney of minipigs and rats. Polycyclic Aromatic Hydrocarbons 18-21 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 42-48 15742974-9 2004 Liver microsomal CYP2E1 is only slightly modulated in its expression by ingestion of PAH-contaminated soils in both species, whereas CYP3A-dependent testosterone 2beta- and 6beta-hydroxylation is increased in liver of rats but not in minipigs. Polycyclic Aromatic Hydrocarbons 85-88 cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus 17-23 15183461-3 2004 In addition to the rapid effect, we have also found that the eNOS mRNA and protein expression were augmented in HUVECs treated with PAHs at concentration as low as 0.1 microM for 24 h. These effects were abolished when the HUVECs were pretreated with the BAPTA, NiCl(2) and SKF96365, as well as SKF525A. Polycyclic Aromatic Hydrocarbons 132-136 nitric oxide synthase 3 Homo sapiens 61-65 15355699-8 2004 CONCLUSION: Genetic polymorphism of mEH gene could be a susceptible biomarker in coke oven workers which was involved in the individual susceptibility on metabolism of PAHs. Polycyclic Aromatic Hydrocarbons 168-172 epoxide hydrolase 1, microsomal Mus musculus 36-39 15183461-4 2004 Our results revealed that, for the first time, PAHs induce the activation of eNOS and enhance eNOS protein expression in HUVECs both in a Ca(2+)-dependent manner. Polycyclic Aromatic Hydrocarbons 47-51 nitric oxide synthase 3 Homo sapiens 77-81 15183461-4 2004 Our results revealed that, for the first time, PAHs induce the activation of eNOS and enhance eNOS protein expression in HUVECs both in a Ca(2+)-dependent manner. Polycyclic Aromatic Hydrocarbons 47-51 nitric oxide synthase 3 Homo sapiens 94-98 15172585-4 2004 The temperature dependence of gas-phase atmospheric concentration of PAHs, C(g), was investigated using diagrams of natural logarithm of partial pressures (lnP) vs. reciprocal mid-point temperatures. Polycyclic Aromatic Hydrocarbons 69-73 lunapark, ER junction formation factor Homo sapiens 156-159 15212524-2 2004 The scope of this methodology was broadened by application to a much larger polycyclic aromatic hydrocarbon (PAH) with a more extended "zig/zag" character. Polycyclic Aromatic Hydrocarbons 76-107 alpha-2-glycoprotein 1, zinc-binding Homo sapiens 140-143 14988221-1 2004 Microsomal epoxide hydrolase (mEH) is involved in the bioactivation and detoxification of polycyclic aromatic hydrocarbons derived from tobacco smoke and charred meat intake. Polycyclic Aromatic Hydrocarbons 90-122 epoxide hydrolase 1, microsomal Mus musculus 30-33 15122594-2 2004 Glutathione S-transferase (GST) M1, T1 and P1 are involved in the detoxification of PAH reactive metabolites. Polycyclic Aromatic Hydrocarbons 84-87 glutathione S-transferase mu 1 Homo sapiens 0-34 15122594-4 2004 Cytochrome p450 1B1 (CYP1B1) and sulfotransferase 1A1 (SULT1A1) are also involved in the metabolism of PAHs and aromatic amines. Polycyclic Aromatic Hydrocarbons 103-107 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 15122594-4 2004 Cytochrome p450 1B1 (CYP1B1) and sulfotransferase 1A1 (SULT1A1) are also involved in the metabolism of PAHs and aromatic amines. Polycyclic Aromatic Hydrocarbons 103-107 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 15122594-4 2004 Cytochrome p450 1B1 (CYP1B1) and sulfotransferase 1A1 (SULT1A1) are also involved in the metabolism of PAHs and aromatic amines. Polycyclic Aromatic Hydrocarbons 103-107 sulfotransferase family 1A member 1 Homo sapiens 33-53 15122594-4 2004 Cytochrome p450 1B1 (CYP1B1) and sulfotransferase 1A1 (SULT1A1) are also involved in the metabolism of PAHs and aromatic amines. Polycyclic Aromatic Hydrocarbons 103-107 sulfotransferase family 1A member 1 Homo sapiens 55-62 15212524-2 2004 The scope of this methodology was broadened by application to a much larger polycyclic aromatic hydrocarbon (PAH) with a more extended "zig/zag" character. Polycyclic Aromatic Hydrocarbons 109-112 alpha-2-glycoprotein 1, zinc-binding Homo sapiens 140-143 14729580-12 2004 MnSOD Val/Val genotype increased the risk of bladder cancer with OR of 1.91 (95% CI = 1.20-3.04), and there was a combined effect with smoking (OR = 7.20, 95% CI = 3.23-16.1) and PAH (OR = 3.02, 95% CI = 1.35-6.74). Polycyclic Aromatic Hydrocarbons 179-182 superoxide dismutase 2 Homo sapiens 0-5 15028720-2 2004 The CYP1 enzymes are responsible for both metabolically activating and detoxifying numerous polycyclic aromatic hydrocarbons (PAHs) and aromatic amines present in combustion products. Polycyclic Aromatic Hydrocarbons 92-124 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 15028720-2 2004 The CYP1 enzymes are responsible for both metabolically activating and detoxifying numerous polycyclic aromatic hydrocarbons (PAHs) and aromatic amines present in combustion products. Polycyclic Aromatic Hydrocarbons 126-130 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 15028720-4 2004 Differences in AHR affinity between inbred mouse strains reflect variations in CYP1 inducibility and clearly have been shown to be associated with differences in risk of toxicity or cancer caused by PAHs and arylamines. Polycyclic Aromatic Hydrocarbons 199-203 aryl-hydrocarbon receptor Mus musculus 15-18 15028720-6 2004 Mouse lines having one or another of the Cyp1 genes disrupted have shown paradoxical effects; in the test tube or in cell culture these enzymes show metabolic activation of PAHs or arylamines, whereas in the intact animal these enzymes are sometimes more important in the role of detoxification than metabolic potentiation. Polycyclic Aromatic Hydrocarbons 173-177 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 41-45 15081398-0 2004 Cytochrome P450-dependent toxicity of environmental polycyclic aromatic hydrocarbons towards human macrophages. Polycyclic Aromatic Hydrocarbons 52-84 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 15116228-1 2004 The proposed method was successful in the determination and separation of lower sub ppt levels of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 98-130 tachykinin precursor 1 Homo sapiens 84-87 15170815-0 2004 Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cells. Polycyclic Aromatic Hydrocarbons 24-56 jun proto-oncogene Mus musculus 79-83 15170815-0 2004 Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-kappaB in mouse epidermal cl41 cells. Polycyclic Aromatic Hydrocarbons 24-56 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 88-97 15159317-12 2004 Collectively, the results demonstrate that some smokers can achieve substantial reductions in 1-HOP, reflecting reduced uptake of polycyclic aromatic hydrocarbons, by reducing CPD, but there was not a consistent relationship between these parameters. Polycyclic Aromatic Hydrocarbons 130-162 carboxypeptidase D Homo sapiens 176-179 15041462-11 2004 It is suggested that the capacity of human CYP1A1 to metabolize AA and EPA and its inducibility by polycyclic aromatic hydrocarbons may affect the production of physiologically active metabolites, in particular, in the cardiovascular system and other extrahepatic tissues including lung. Polycyclic Aromatic Hydrocarbons 99-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-49 14993811-0 2004 Polycyclic aromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor. Polycyclic Aromatic Hydrocarbons 0-31 interleukin 1 beta Homo sapiens 57-75 14993811-0 2004 Polycyclic aromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor. Polycyclic Aromatic Hydrocarbons 0-31 aryl hydrocarbon receptor Homo sapiens 122-147 14993811-3 2004 When human fibroblast-like synoviocytes line, MH7A, was treated with 3-methylcholanthrene (3-MC), a polycyclic aromatic hydrocarbon (PAH), mRNA of IL-1beta was up-regulated. Polycyclic Aromatic Hydrocarbons 100-131 interleukin 1 beta Homo sapiens 147-155 15183118-1 2004 The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that can be activated by a diverse synthetic and naturally-occurring chemicals, such as the halogenated aromatic hydrocarbons (HAHs) and the non-halogenated polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 236-268 aryl hydrocarbon receptor 1a Danio rerio 4-29 15183118-1 2004 The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that can be activated by a diverse synthetic and naturally-occurring chemicals, such as the halogenated aromatic hydrocarbons (HAHs) and the non-halogenated polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 236-268 aryl hydrocarbon receptor 1a Danio rerio 31-34 15183118-1 2004 The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that can be activated by a diverse synthetic and naturally-occurring chemicals, such as the halogenated aromatic hydrocarbons (HAHs) and the non-halogenated polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 270-274 aryl hydrocarbon receptor 1a Danio rerio 4-29 15183118-1 2004 The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that can be activated by a diverse synthetic and naturally-occurring chemicals, such as the halogenated aromatic hydrocarbons (HAHs) and the non-halogenated polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 270-274 aryl hydrocarbon receptor 1a Danio rerio 31-34 15081870-1 2004 We examined the effects of amiloride derivatives, especially 5-(N-ethyl-N-isopropyl)amiloride (EIPA), on the activity of cytochrome P450 (CYP) 1 isoforms, known to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP), into mutagenic metabolites and whose cellular expression can be induced through interaction of PAHs with the arylhydrocarbon receptor. Polycyclic Aromatic Hydrocarbons 188-220 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-144 15081870-1 2004 We examined the effects of amiloride derivatives, especially 5-(N-ethyl-N-isopropyl)amiloride (EIPA), on the activity of cytochrome P450 (CYP) 1 isoforms, known to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP), into mutagenic metabolites and whose cellular expression can be induced through interaction of PAHs with the arylhydrocarbon receptor. Polycyclic Aromatic Hydrocarbons 222-226 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-144 15081870-1 2004 We examined the effects of amiloride derivatives, especially 5-(N-ethyl-N-isopropyl)amiloride (EIPA), on the activity of cytochrome P450 (CYP) 1 isoforms, known to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP), into mutagenic metabolites and whose cellular expression can be induced through interaction of PAHs with the arylhydrocarbon receptor. Polycyclic Aromatic Hydrocarbons 353-357 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 121-144 15081870-6 2004 The present data suggest that amiloride derivatives, such as EIPA, may be useful for preventing toxicity of chemical carcinogens, such as PAHs, through inhibition of CYP1 enzyme activity. Polycyclic Aromatic Hydrocarbons 138-142 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 166-170 15114261-10 2004 CONCLUSIONS: The presence of AHR in sperm provides a mechanism by which environmental dioxins, polycyclic aromatic hydrocarbons and polyhalogenated biphenyls could directly influence sperm function. Polycyclic Aromatic Hydrocarbons 95-127 aryl hydrocarbon receptor Homo sapiens 29-32 15102951-1 2004 The cytochrome P450 (CYP1A1) enzyme metabolically activates many polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), to DNA- and protein-binding intermediates that are associated with toxicity, mutagenesis, and carcinogenesis. Polycyclic Aromatic Hydrocarbons 65-97 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 21-27 15102951-1 2004 The cytochrome P450 (CYP1A1) enzyme metabolically activates many polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), to DNA- and protein-binding intermediates that are associated with toxicity, mutagenesis, and carcinogenesis. Polycyclic Aromatic Hydrocarbons 65-97 prohibitin 2 Mus musculus 125-128 14976333-12 2004 At the same time, Cag caused a marked inhibition of DMBA-induced aryl hydrocarbon hydroxylase (AHH) activity, an enzyme responsible for the metabolism of PAHs like BP, both in vivo and in vitro. Polycyclic Aromatic Hydrocarbons 154-158 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 65-93 14976333-12 2004 At the same time, Cag caused a marked inhibition of DMBA-induced aryl hydrocarbon hydroxylase (AHH) activity, an enzyme responsible for the metabolism of PAHs like BP, both in vivo and in vitro. Polycyclic Aromatic Hydrocarbons 154-158 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 95-98 14764592-2 2004 ARNT is also a dimeric partner for the Ah receptor (AHR), and this complex is essential in regulating the adaptive metabolic response to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 137-169 aryl hydrocarbon receptor nuclear translocator Mus musculus 0-4 14764592-2 2004 ARNT is also a dimeric partner for the Ah receptor (AHR), and this complex is essential in regulating the adaptive metabolic response to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 137-169 aryl-hydrocarbon receptor Mus musculus 39-50 14764592-2 2004 ARNT is also a dimeric partner for the Ah receptor (AHR), and this complex is essential in regulating the adaptive metabolic response to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 137-169 aryl-hydrocarbon receptor Mus musculus 52-55 15116840-3 2004 This trend for E2 and NP is similar to that obtained by other researchers for moderately hydrophobic compounds including polycyclic aromatic hydrocarbons with three or four rings. Polycyclic Aromatic Hydrocarbons 121-153 cystatin 12, pseudogene Homo sapiens 15-24 14578163-1 2004 Concomitant exposures to arsenic and polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) are widespread. Polycyclic Aromatic Hydrocarbons 37-69 prohibitin 2 Mus musculus 101-104 14578163-1 2004 Concomitant exposures to arsenic and polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) are widespread. Polycyclic Aromatic Hydrocarbons 71-75 prohibitin 2 Mus musculus 101-104 15050408-7 2004 This activity was dependent on the metabolism of PAHs in MCF-7 cells via the AhR pathway, which resulted in the formation of metabolites that bound the ER. Polycyclic Aromatic Hydrocarbons 49-53 aryl hydrocarbon receptor Homo sapiens 77-80 15036119-10 2004 Multiple linear regression analysis showed that the increase in anti-BPDE-DNA adduct levels in LMF was significantly related to the high occupational exposure to PAHs (benzo[a]pyrene (BaP)) of coke-oven workers (t = 3.087, P < 0.01) and to the lack of GSTM1 activity (t = 3.512, P < 0.001), rather than to the two other confounding factors of PAH intake, i.e. charcoal-broiled meat consumption and smoking habits. Polycyclic Aromatic Hydrocarbons 162-166 glutathione S-transferase mu 1 Homo sapiens 255-260 15061915-12 2004 CONCLUSION: Significant associations between genetic polymorphisms in GSTM1, NQO1 and mEH gene and risk for chromosomal damage were found among occupational PAH-exposed workers, which related to the mechanism of PAH carcinogenesis. Polycyclic Aromatic Hydrocarbons 157-160 glutathione S-transferase mu 1 Homo sapiens 70-75 15061915-12 2004 CONCLUSION: Significant associations between genetic polymorphisms in GSTM1, NQO1 and mEH gene and risk for chromosomal damage were found among occupational PAH-exposed workers, which related to the mechanism of PAH carcinogenesis. Polycyclic Aromatic Hydrocarbons 157-160 NAD(P)H quinone dehydrogenase 1 Homo sapiens 77-81 15061915-12 2004 CONCLUSION: Significant associations between genetic polymorphisms in GSTM1, NQO1 and mEH gene and risk for chromosomal damage were found among occupational PAH-exposed workers, which related to the mechanism of PAH carcinogenesis. Polycyclic Aromatic Hydrocarbons 157-160 epoxide hydrolase 1, microsomal Mus musculus 86-89 15061915-12 2004 CONCLUSION: Significant associations between genetic polymorphisms in GSTM1, NQO1 and mEH gene and risk for chromosomal damage were found among occupational PAH-exposed workers, which related to the mechanism of PAH carcinogenesis. Polycyclic Aromatic Hydrocarbons 212-215 glutathione S-transferase mu 1 Homo sapiens 70-75 14759198-1 2004 Cyclophanes with the largest-to-date polycyclic aromatic hydrocarbon (hexa-peri-hexabenzocoronene, HBC) to be entrained in such a structural motif are reported. Polycyclic Aromatic Hydrocarbons 37-68 hexosaminidase subunit alpha Homo sapiens 70-74 14759198-1 2004 Cyclophanes with the largest-to-date polycyclic aromatic hydrocarbon (hexa-peri-hexabenzocoronene, HBC) to be entrained in such a structural motif are reported. Polycyclic Aromatic Hydrocarbons 37-68 keratin 88, pseudogene Homo sapiens 99-102 14625279-0 2004 Chromium inhibits transcription from polycyclic aromatic hydrocarbon-inducible promoters by blocking the release of histone deacetylase and preventing the binding of p300 to chromatin. Polycyclic Aromatic Hydrocarbons 37-68 E1A binding protein p300 Mus musculus 166-170 15061915-12 2004 CONCLUSION: Significant associations between genetic polymorphisms in GSTM1, NQO1 and mEH gene and risk for chromosomal damage were found among occupational PAH-exposed workers, which related to the mechanism of PAH carcinogenesis. Polycyclic Aromatic Hydrocarbons 212-215 NAD(P)H quinone dehydrogenase 1 Homo sapiens 77-81 15061915-12 2004 CONCLUSION: Significant associations between genetic polymorphisms in GSTM1, NQO1 and mEH gene and risk for chromosomal damage were found among occupational PAH-exposed workers, which related to the mechanism of PAH carcinogenesis. Polycyclic Aromatic Hydrocarbons 212-215 epoxide hydrolase 1, microsomal Mus musculus 86-89 15116228-1 2004 The proposed method was successful in the determination and separation of lower sub ppt levels of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 132-136 tachykinin precursor 1 Homo sapiens 84-87 15077014-1 2004 The aryl hydrocarbon receptor (AHR) gene encodes a ligand-activated transcription factor through which planar halogenated aromatic hydrocarbons (HAHs) such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as well as polynuclear aromatic hydrocarbons (PAHs) cause altered gene expression and toxicity. Polycyclic Aromatic Hydrocarbons 213-246 aryl hydrocarbon receptor Homo sapiens 31-34 15077014-1 2004 The aryl hydrocarbon receptor (AHR) gene encodes a ligand-activated transcription factor through which planar halogenated aromatic hydrocarbons (HAHs) such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as well as polynuclear aromatic hydrocarbons (PAHs) cause altered gene expression and toxicity. Polycyclic Aromatic Hydrocarbons 248-252 aryl hydrocarbon receptor Homo sapiens 31-34 14691214-2 2004 Benzo[a]pyrene (BaP), a prototypical polycyclic aromatic hydrocarbon (PAH), can be bioactivated by cytochrome P-450s (CYPs) and epoxide hydrolase to genotoxic metabolites which form covalent adducts with DNA. Polycyclic Aromatic Hydrocarbons 37-68 prohibitin 2 Rattus norvegicus 16-19 14691214-2 2004 Benzo[a]pyrene (BaP), a prototypical polycyclic aromatic hydrocarbon (PAH), can be bioactivated by cytochrome P-450s (CYPs) and epoxide hydrolase to genotoxic metabolites which form covalent adducts with DNA. Polycyclic Aromatic Hydrocarbons 70-73 prohibitin 2 Rattus norvegicus 16-19 14720319-0 2004 Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1. Polycyclic Aromatic Hydrocarbons 24-56 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 87-103 16106736-4 2004 CYP1B1 that is constitutive expressed by stromal cells plays probably the main role in biotransformation of PAH in bone marrow. Polycyclic Aromatic Hydrocarbons 108-111 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-6 14727725-4 2004 Results show a two-fold, or 75%, PAH contaminant degradation by Mycobacterium PRY-1 over a 140-day growth period. Polycyclic Aromatic Hydrocarbons 33-36 PTPN13 like Y-linked Homo sapiens 78-83 14720319-3 2004 Cytochrome P450 (CYP) enzymes are central to the metabolic activation of these PAHs to epoxide intermediates, which are converted with the aid of epoxide hydrolase to the ultimate carcinogens, diol-epoxides. Polycyclic Aromatic Hydrocarbons 79-83 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 0-15 14720319-3 2004 Cytochrome P450 (CYP) enzymes are central to the metabolic activation of these PAHs to epoxide intermediates, which are converted with the aid of epoxide hydrolase to the ultimate carcinogens, diol-epoxides. Polycyclic Aromatic Hydrocarbons 79-83 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 17-20 14720319-4 2004 Historically, CYP1A1 was believed to be the only enzyme that catalyzes activation of these procarcinogenic PAHs. Polycyclic Aromatic Hydrocarbons 107-111 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 14-20 15750580-2 2004 The CYP1 family is of particular interest in environmental toxicology because its members are dominant in the metabolism of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and aryl amines. Polycyclic Aromatic Hydrocarbons 124-156 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 14744742-0 2004 Albumin adducts of naphthalene metabolites as biomarkers of exposure to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 72-104 albumin Homo sapiens 0-7 14740720-6 2004 Inhalation risk associated with carcinogenic PAHs was estimated by using toxic equivalency factors based on the potency of benzo[a]pyrene (BaP). Polycyclic Aromatic Hydrocarbons 45-49 prohibitin 2 Homo sapiens 139-142 14740720-7 2004 The carcinogenicity of the indoor PAH mixture was dominated by naphthalene followed by BaP and dibenz[a,h]anthracene. Polycyclic Aromatic Hydrocarbons 34-37 prohibitin 2 Homo sapiens 87-90 15750580-2 2004 The CYP1 family is of particular interest in environmental toxicology because its members are dominant in the metabolism of polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and aryl amines. Polycyclic Aromatic Hydrocarbons 158-162 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-8 15272713-1 2004 The sorption behavior was determined for a model polycyclic aromatic hydrocarbon (PAH), i.e., phenanthrene(PHN), from water to three humic acids (HAs) and three sediments in different reacting time. Polycyclic Aromatic Hydrocarbons 49-80 carbamoyl-phosphate synthase 1 Homo sapiens 107-110 15055970-1 2004 We describe a method for the simultaneous determination of 12 kinds of polycyclic aromatic hydrocarbons (PAHs) in sediment based on liquid chromatography-atmospheric pressure photoionization-mass spectrometry (LC/APPI/MS). Polycyclic Aromatic Hydrocarbons 71-103 amyloid beta precursor protein Homo sapiens 213-217 15055970-1 2004 We describe a method for the simultaneous determination of 12 kinds of polycyclic aromatic hydrocarbons (PAHs) in sediment based on liquid chromatography-atmospheric pressure photoionization-mass spectrometry (LC/APPI/MS). Polycyclic Aromatic Hydrocarbons 105-109 amyloid beta precursor protein Homo sapiens 213-217 15533005-8 2004 An evaluation of the relation between the share of the fraction extracted with n-butanol from the different types of sludge and the properties of the PAHs showed that statistically, there existed significant (P < 0.05) correlations between log Koc (in the case of one sewage sludge) and between the nitrogen content, the ratio of C/N, cations Mg2+ and K+ (in the case of a few PAHs). Polycyclic Aromatic Hydrocarbons 150-154 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 247-250 15272713-1 2004 The sorption behavior was determined for a model polycyclic aromatic hydrocarbon (PAH), i.e., phenanthrene(PHN), from water to three humic acids (HAs) and three sediments in different reacting time. Polycyclic Aromatic Hydrocarbons 82-85 carbamoyl-phosphate synthase 1 Homo sapiens 107-110 14693744-13 2003 Thus, trans, anti-PheT appears to be an excellent biomarker of PAH uptake. Polycyclic Aromatic Hydrocarbons 63-66 sperm associated antigen 9 Homo sapiens 18-22 15176217-6 2004 The CYP1A1 allele incidence (19%) in patients with squamous lung cancer was significantly higher than in the control cohorts (11%) which is consistent with the leading role of PAH in the etiology of this pathology. Polycyclic Aromatic Hydrocarbons 176-179 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-10 14695173-1 2003 Cytochrome P4501A1 (CYP1A1), which is involved in the metabolic activation of polycyclic aromatic hydrocarbon procarcinogens derived from tobacco smoke, is induced in the lung up to 100-fold because of tobacco smoking. Polycyclic Aromatic Hydrocarbons 78-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 14695185-3 2003 Mapping of DNA adducts by terminal transferase-dependent PCR showed the preferential formation of bulky adducts at identical nucleotide positions along the cII gene after treatment with the prototype polycyclic aromatic hydrocarbon, benzo(a)pyrene diol epoxide [B(a)PDE], or B(a)PDE plus UVA radiation treatments but not after UVA irradiation alone. Polycyclic Aromatic Hydrocarbons 200-231 polymerase (DNA directed), mu Mus musculus 26-46 12939788-1 2003 Human cytochrome P450 (CYP)1B1 is a major enzyme for carcinogenic estrogen metabolism and involved in the metabolic activation of procarcinogens of the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 152-184 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 6-30 12939788-1 2003 Human cytochrome P450 (CYP)1B1 is a major enzyme for carcinogenic estrogen metabolism and involved in the metabolic activation of procarcinogens of the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 186-190 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 6-30 14710844-4 2003 The results obtained for several polycyclic aromatic hydrocarbons and biochemical substances show that sufficient acceleration can be achieved even for molecules with a molecular weight above 5000 amu and that HSI preserves its advantageous features even for thermally labile large molecules such as insulin. Polycyclic Aromatic Hydrocarbons 33-65 aldo-keto reductase family 1 member B10 Homo sapiens 210-213 12963398-1 2003 Cytochromes P4501B1 (CYP1B1) and P4501A1 (CYP1A1) are involved in the metabolic activation of many polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 99-131 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 12-19 12963398-1 2003 Cytochromes P4501B1 (CYP1B1) and P4501A1 (CYP1A1) are involved in the metabolic activation of many polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 99-131 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 12963398-1 2003 Cytochromes P4501B1 (CYP1B1) and P4501A1 (CYP1A1) are involved in the metabolic activation of many polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 99-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-48 12963398-1 2003 Cytochromes P4501B1 (CYP1B1) and P4501A1 (CYP1A1) are involved in the metabolic activation of many polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 133-136 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 12-19 12963398-1 2003 Cytochromes P4501B1 (CYP1B1) and P4501A1 (CYP1A1) are involved in the metabolic activation of many polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 133-136 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 12963398-1 2003 Cytochromes P4501B1 (CYP1B1) and P4501A1 (CYP1A1) are involved in the metabolic activation of many polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 133-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-48 12946434-3 2003 We have characterized the influence of pyrene, a polycyclic aromatic hydrocarbon (PAH) contained, for example, in diesel exhaust particles (DEP), on transcription and secretion of the chemokines interleukin-8 (IL-8) and eotaxin. Polycyclic Aromatic Hydrocarbons 49-80 C-X-C motif chemokine ligand 8 Homo sapiens 195-208 12946434-3 2003 We have characterized the influence of pyrene, a polycyclic aromatic hydrocarbon (PAH) contained, for example, in diesel exhaust particles (DEP), on transcription and secretion of the chemokines interleukin-8 (IL-8) and eotaxin. Polycyclic Aromatic Hydrocarbons 82-85 C-X-C motif chemokine ligand 8 Homo sapiens 195-208 14756296-0 2003 Polycyclic aromatic hydrocarbons and aliphatics in the coral reef skeleton of the Egyptian Red Sea coast. Polycyclic Aromatic Hydrocarbons 0-32 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 95-98 12970580-9 2003 Equimolar mixtures of ten polycyclic aromatic hydrocarbons (PAHs) having four or more rings, structures found in the DEPEs, showed significant antiandrogenic effects and AhR agonist activity at concentrations equivalent to those found in DEPE samples. Polycyclic Aromatic Hydrocarbons 26-58 aryl hydrocarbon receptor Homo sapiens 170-173 12970580-9 2003 Equimolar mixtures of ten polycyclic aromatic hydrocarbons (PAHs) having four or more rings, structures found in the DEPEs, showed significant antiandrogenic effects and AhR agonist activity at concentrations equivalent to those found in DEPE samples. Polycyclic Aromatic Hydrocarbons 60-64 aryl hydrocarbon receptor Homo sapiens 170-173 14514961-2 2003 In a model system of B lymphopoiesis, PAH exposure rapidly induces apoptosis in CD43- pre-B and CD43+ pro/pre-B cells. Polycyclic Aromatic Hydrocarbons 38-41 sialophorin Homo sapiens 80-84 14514961-2 2003 In a model system of B lymphopoiesis, PAH exposure rapidly induces apoptosis in CD43- pre-B and CD43+ pro/pre-B cells. Polycyclic Aromatic Hydrocarbons 38-41 sialophorin Homo sapiens 96-100 14520703-3 2003 We analyzed the relationship between past occupational exposure to dyes, metals, polycyclic aromatic hydrocarbons (PAHs) and other agents and mutations in codon 12 of the K-ras gene in 107 incident cases of EPC. Polycyclic Aromatic Hydrocarbons 115-119 KRAS proto-oncogene, GTPase Homo sapiens 171-176 14520703-9 2003 There was some indication of weaker associations between K-ras mutations and occupational exposure to lead, PAHs, benzo[a]pyrene, gasoline, nickel, inhalatory exposure to chromium and sedentary work. Polycyclic Aromatic Hydrocarbons 108-112 KRAS proto-oncogene, GTPase Homo sapiens 57-62 14761400-0 2003 [Co-detection of P21, P53 and HSP70 and their possible role in diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer]. Polycyclic Aromatic Hydrocarbons 76-108 H3 histone pseudogene 16 Homo sapiens 17-20 14761400-0 2003 [Co-detection of P21, P53 and HSP70 and their possible role in diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer]. Polycyclic Aromatic Hydrocarbons 76-108 heat shock protein family A (Hsp70) member 4 Homo sapiens 30-35 14761400-0 2003 [Co-detection of P21, P53 and HSP70 and their possible role in diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer]. Polycyclic Aromatic Hydrocarbons 110-114 H3 histone pseudogene 16 Homo sapiens 17-20 14761400-0 2003 [Co-detection of P21, P53 and HSP70 and their possible role in diagnosis of polycyclic aromatic hydrocarbons (PAHs)-related lung cancer]. Polycyclic Aromatic Hydrocarbons 110-114 heat shock protein family A (Hsp70) member 4 Homo sapiens 30-35 12919721-1 2003 The aim of the present study is to evaluate the influence of the genetic polymorphism of two enzymes involved in the biotransformation of xenobiotics, cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), on the urinary levels of 1-hydroxypyrene (1-OH-P) in workers exposed to polycyclic aromatic hydrocarbons (PAHs) and in unexposed workers (controls). Polycyclic Aromatic Hydrocarbons 294-326 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 151-170 12919721-1 2003 The aim of the present study is to evaluate the influence of the genetic polymorphism of two enzymes involved in the biotransformation of xenobiotics, cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), on the urinary levels of 1-hydroxypyrene (1-OH-P) in workers exposed to polycyclic aromatic hydrocarbons (PAHs) and in unexposed workers (controls). Polycyclic Aromatic Hydrocarbons 294-326 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 172-178 12919721-1 2003 The aim of the present study is to evaluate the influence of the genetic polymorphism of two enzymes involved in the biotransformation of xenobiotics, cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), on the urinary levels of 1-hydroxypyrene (1-OH-P) in workers exposed to polycyclic aromatic hydrocarbons (PAHs) and in unexposed workers (controls). Polycyclic Aromatic Hydrocarbons 294-326 glutathione S-transferase mu 1 Homo sapiens 184-212 12919721-1 2003 The aim of the present study is to evaluate the influence of the genetic polymorphism of two enzymes involved in the biotransformation of xenobiotics, cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), on the urinary levels of 1-hydroxypyrene (1-OH-P) in workers exposed to polycyclic aromatic hydrocarbons (PAHs) and in unexposed workers (controls). Polycyclic Aromatic Hydrocarbons 294-326 glutathione S-transferase mu 1 Homo sapiens 214-219 12919721-1 2003 The aim of the present study is to evaluate the influence of the genetic polymorphism of two enzymes involved in the biotransformation of xenobiotics, cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), on the urinary levels of 1-hydroxypyrene (1-OH-P) in workers exposed to polycyclic aromatic hydrocarbons (PAHs) and in unexposed workers (controls). Polycyclic Aromatic Hydrocarbons 328-332 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 151-170 12919721-1 2003 The aim of the present study is to evaluate the influence of the genetic polymorphism of two enzymes involved in the biotransformation of xenobiotics, cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), on the urinary levels of 1-hydroxypyrene (1-OH-P) in workers exposed to polycyclic aromatic hydrocarbons (PAHs) and in unexposed workers (controls). Polycyclic Aromatic Hydrocarbons 328-332 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 172-178 12919721-1 2003 The aim of the present study is to evaluate the influence of the genetic polymorphism of two enzymes involved in the biotransformation of xenobiotics, cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), on the urinary levels of 1-hydroxypyrene (1-OH-P) in workers exposed to polycyclic aromatic hydrocarbons (PAHs) and in unexposed workers (controls). Polycyclic Aromatic Hydrocarbons 328-332 glutathione S-transferase mu 1 Homo sapiens 184-212 12919721-1 2003 The aim of the present study is to evaluate the influence of the genetic polymorphism of two enzymes involved in the biotransformation of xenobiotics, cytochrome P450 1A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), on the urinary levels of 1-hydroxypyrene (1-OH-P) in workers exposed to polycyclic aromatic hydrocarbons (PAHs) and in unexposed workers (controls). Polycyclic Aromatic Hydrocarbons 328-332 glutathione S-transferase mu 1 Homo sapiens 214-219 12935919-1 2003 Microsomal epoxide hydrolase (mEH) gene is polymorphic and its enzyme is involved in the activation and subsequent detoxification of several tobacco carcinogens, for example polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 174-206 epoxide hydrolase 1, microsomal Mus musculus 30-33 12967097-0 2003 Sea breeze modulated volatilization of polycyclic aromatic hydrocarbons from the Masnou Harbor (NW Mediterranean Sea). Polycyclic Aromatic Hydrocarbons 39-71 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 0-3 12967097-0 2003 Sea breeze modulated volatilization of polycyclic aromatic hydrocarbons from the Masnou Harbor (NW Mediterranean Sea). Polycyclic Aromatic Hydrocarbons 39-71 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 113-116 14646292-0 2003 Urinary PAH metabolites influenced by genetic polymorphisms of GSTM1 in male hospital incinerator workers. Polycyclic Aromatic Hydrocarbons 8-11 glutathione S-transferase mu 1 Homo sapiens 63-68 14514444-2 2003 To determine the biological effects of 23 polycyclic aromatic hydrocarbons (PAHs) and 3,4,3",4"-tetrachlorobiphenyl, the dose-response studies of the induction of CYP1-dependent xenobiotic oxidation activities by these chemicals in liver microsomes of C57BL/6J mice were studied. Polycyclic Aromatic Hydrocarbons 42-74 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 163-167 12842776-2 2003 PAHs require bioactivation by the cytochrome P-450 monooxygenase system to exert toxic/carcinogenic effects. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450, family 2, subfamily j, polypeptide 3 Rattus norvegicus 34-64 12842776-12 2003 This induction of CYP1A1 and QR with the concomitant down-regulation of CYP2B1 after asphalt fume exposure could alter PAH metabolism and may lead to potential toxic effects in the lung. Polycyclic Aromatic Hydrocarbons 119-122 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 18-24 12842776-12 2003 This induction of CYP1A1 and QR with the concomitant down-regulation of CYP2B1 after asphalt fume exposure could alter PAH metabolism and may lead to potential toxic effects in the lung. Polycyclic Aromatic Hydrocarbons 119-122 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 72-78 14582238-4 2003 Genetic polymorphisms that influence human genotoxic risk are those of glutathione s-transferase and cytochrome P450 in exposure to polycyclic aromatic hydrocarbons (PAHs), those of N-acetyltransferase in both occupational and environmental exposures to aromatic amines (AAs) and similar compounds. Polycyclic Aromatic Hydrocarbons 132-164 glutathione S-transferase kappa 1 Homo sapiens 71-96 14582238-4 2003 Genetic polymorphisms that influence human genotoxic risk are those of glutathione s-transferase and cytochrome P450 in exposure to polycyclic aromatic hydrocarbons (PAHs), those of N-acetyltransferase in both occupational and environmental exposures to aromatic amines (AAs) and similar compounds. Polycyclic Aromatic Hydrocarbons 132-164 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 101-116 14582238-4 2003 Genetic polymorphisms that influence human genotoxic risk are those of glutathione s-transferase and cytochrome P450 in exposure to polycyclic aromatic hydrocarbons (PAHs), those of N-acetyltransferase in both occupational and environmental exposures to aromatic amines (AAs) and similar compounds. Polycyclic Aromatic Hydrocarbons 166-170 glutathione S-transferase kappa 1 Homo sapiens 71-96 14582238-4 2003 Genetic polymorphisms that influence human genotoxic risk are those of glutathione s-transferase and cytochrome P450 in exposure to polycyclic aromatic hydrocarbons (PAHs), those of N-acetyltransferase in both occupational and environmental exposures to aromatic amines (AAs) and similar compounds. Polycyclic Aromatic Hydrocarbons 166-170 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 101-116 12826308-10 2003 They also suggest that the mutagens and/or mechanisms of mutations in these nonsmoking women are similar to those responsible for K-ras mutations in cigarette smoking lung cancer patients, which are probably induced largely by chemicals such as PAHs. Polycyclic Aromatic Hydrocarbons 245-249 KRAS proto-oncogene, GTPase Homo sapiens 130-135 12801909-1 2003 Cytochrome P450 (CYP) 1B1 is known to be induced by polycyclic aromatic hydrocarbons including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polycyclic Aromatic Hydrocarbons 52-84 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-25 14504203-0 2003 The interaction between alcohol consumption and GSTM1 genotype on polycyclic aromatic hydrocarbon-DNA adduct levels in breast tissue. Polycyclic Aromatic Hydrocarbons 66-97 glutathione S-transferase mu 1 Homo sapiens 48-53 12837310-0 2003 Polycyclic aromatic hydrocarbons in surficial coastal sediments of the Ligurian Sea. Polycyclic Aromatic Hydrocarbons 0-32 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 80-83 12799773-0 2003 A role of aryl hydrocarbon receptor in the antiandrogenic effects of polycyclic aromatic hydrocarbons in LNCaP human prostate carcinoma cells. Polycyclic Aromatic Hydrocarbons 69-101 aryl hydrocarbon receptor Homo sapiens 10-35 12799773-1 2003 The role of aryl hydrocarbon receptor (AhR) on the antiandrogenic effects of polycyclic aromatic hydrocarbons (PAHs) was studied in LNCaP cells. Polycyclic Aromatic Hydrocarbons 77-109 aryl hydrocarbon receptor Homo sapiens 12-37 12799773-1 2003 The role of aryl hydrocarbon receptor (AhR) on the antiandrogenic effects of polycyclic aromatic hydrocarbons (PAHs) was studied in LNCaP cells. Polycyclic Aromatic Hydrocarbons 77-109 aryl hydrocarbon receptor Homo sapiens 39-42 12799773-10 2003 Since activator protein-1 (AP-1), a heterodimer of c-jun and c-fos proteins, is known to inhibit binding of AR to ARE by protein-protein interaction with AR, the findings in the present study suggest a possible involvement of AP-1 in the antiandrogenic effects of PAHs acting as AhR agonists. Polycyclic Aromatic Hydrocarbons 264-268 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 6-25 12799773-10 2003 Since activator protein-1 (AP-1), a heterodimer of c-jun and c-fos proteins, is known to inhibit binding of AR to ARE by protein-protein interaction with AR, the findings in the present study suggest a possible involvement of AP-1 in the antiandrogenic effects of PAHs acting as AhR agonists. Polycyclic Aromatic Hydrocarbons 264-268 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 27-31 12799773-10 2003 Since activator protein-1 (AP-1), a heterodimer of c-jun and c-fos proteins, is known to inhibit binding of AR to ARE by protein-protein interaction with AR, the findings in the present study suggest a possible involvement of AP-1 in the antiandrogenic effects of PAHs acting as AhR agonists. Polycyclic Aromatic Hydrocarbons 264-268 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 61-66 12799773-10 2003 Since activator protein-1 (AP-1), a heterodimer of c-jun and c-fos proteins, is known to inhibit binding of AR to ARE by protein-protein interaction with AR, the findings in the present study suggest a possible involvement of AP-1 in the antiandrogenic effects of PAHs acting as AhR agonists. Polycyclic Aromatic Hydrocarbons 264-268 androgen receptor Homo sapiens 108-110 12799773-10 2003 Since activator protein-1 (AP-1), a heterodimer of c-jun and c-fos proteins, is known to inhibit binding of AR to ARE by protein-protein interaction with AR, the findings in the present study suggest a possible involvement of AP-1 in the antiandrogenic effects of PAHs acting as AhR agonists. Polycyclic Aromatic Hydrocarbons 264-268 aryl hydrocarbon receptor Homo sapiens 279-282 12807751-8 2003 Therefore, this study suggests that the GSTT1 genetic polymorphism has the potential to affect the biological monitoring of PAHs with urinary 1-OHP, and might act as a genetic factor in PAH-related toxicity. Polycyclic Aromatic Hydrocarbons 124-127 glutathione S-transferase theta 1 Homo sapiens 40-45 12930004-0 2003 Paraxanthine/caffeine ratio: as an index for CYP1A2 activity in polycyclic aromatic hydrocarbons exposed subjects. Polycyclic Aromatic Hydrocarbons 64-96 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 45-51 12930004-3 2003 PAHs have been well established as an enzyme inducer of cytochrome P450 (CYP) such as CYP1A1 and CYP1A2. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 56-71 12930004-3 2003 PAHs have been well established as an enzyme inducer of cytochrome P450 (CYP) such as CYP1A1 and CYP1A2. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 73-76 12930004-3 2003 PAHs have been well established as an enzyme inducer of cytochrome P450 (CYP) such as CYP1A1 and CYP1A2. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 86-92 12930004-3 2003 PAHs have been well established as an enzyme inducer of cytochrome P450 (CYP) such as CYP1A1 and CYP1A2. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 97-103 12930004-12 2003 CONCLUSION: Paraxanthine/caffeine ratio, as an index for CYP1A2 activity, can be used to determine PAHs exposure. Polycyclic Aromatic Hydrocarbons 99-103 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 57-63 12734332-2 2003 The PAH-induced death signaling pathway resembles the signaling cascade activated during clonal deletion and modeled by B cell receptor cross-linking or by dexamethasone exposure of immature surface Ig(+) B cells in that apoptosis is mediated by NF-kappa B down-regulation. Polycyclic Aromatic Hydrocarbons 4-7 nuclear factor kappa B subunit 1 Homo sapiens 246-256 12734332-5 2003 As in clonal deletion models, and as predicted by the down-regulation of NF-kappa B, PAH-induced death of pro/pre-B cells was at least partially dependent on c-Myc down-regulation. Polycyclic Aromatic Hydrocarbons 85-88 nuclear factor kappa B subunit 1 Homo sapiens 73-83 12734332-5 2003 As in clonal deletion models, and as predicted by the down-regulation of NF-kappa B, PAH-induced death of pro/pre-B cells was at least partially dependent on c-Myc down-regulation. Polycyclic Aromatic Hydrocarbons 85-88 MYC proto-oncogene, bHLH transcription factor Homo sapiens 158-163 12734332-7 2003 Finally, in contrast to clonal deletion, PAH-induced pro/pre-B cell death was not dependent on p27(Kip1) or p21(WAF1) up-regulation but did coincide with p53 induction. Polycyclic Aromatic Hydrocarbons 41-44 tumor protein p53 Homo sapiens 154-157 12785736-1 2003 Certain polycyclic aromatic hydrocarbons (PAHs) have been reported to induce cytochrome P450 (CYP) 1A1 and 1A2. Polycyclic Aromatic Hydrocarbons 8-40 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 77-110 12785736-1 2003 Certain polycyclic aromatic hydrocarbons (PAHs) have been reported to induce cytochrome P450 (CYP) 1A1 and 1A2. Polycyclic Aromatic Hydrocarbons 42-46 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 77-110 12711114-1 2003 The p53 gene is frequently mutated in lung tumors, and mutations may be caused by both polycyclic aromatic hydrocarbons (PAHs) and nitrosamines found in tobacco smoke. Polycyclic Aromatic Hydrocarbons 87-119 tumor protein p53 Homo sapiens 4-7 12711114-1 2003 The p53 gene is frequently mutated in lung tumors, and mutations may be caused by both polycyclic aromatic hydrocarbons (PAHs) and nitrosamines found in tobacco smoke. Polycyclic Aromatic Hydrocarbons 121-125 tumor protein p53 Homo sapiens 4-7 12711114-12 2003 These results suggest that p53 mutations in both types of lung tumors may arise from adduction by both PAHs and nitrosamines. Polycyclic Aromatic Hydrocarbons 103-107 tumor protein p53 Homo sapiens 27-30 14646292-3 2003 The potential effect of genetic polymorphisms of GSTM1/T1 involved in PAH metabolisms was also investigated. Polycyclic Aromatic Hydrocarbons 70-73 glutathione S-transferase mu 1 Homo sapiens 49-54 12673023-3 2003 Most of the aza-PAHs showed similar or more potent AhR ligand activities than the corresponding parent PAHs. Polycyclic Aromatic Hydrocarbons 16-20 aryl hydrocarbon receptor Homo sapiens 51-54 12698233-3 2003 Between these treatments, PAH-metabolizing activities encoded by aryl hydrocarbon (Ah) receptor-controlled genes were induced in the rats with beta-naphthoflavone (betaNF). Polycyclic Aromatic Hydrocarbons 26-29 aryl hydrocarbon receptor Rattus norvegicus 65-95 12673023-1 2003 Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor through which dioxins and carcinogenic polycyclic aromatic hydrocarbons cause altered gene expression and toxicity. Polycyclic Aromatic Hydrocarbons 114-146 aryl hydrocarbon receptor Homo sapiens 0-25 12673023-1 2003 Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor through which dioxins and carcinogenic polycyclic aromatic hydrocarbons cause altered gene expression and toxicity. Polycyclic Aromatic Hydrocarbons 114-146 aryl hydrocarbon receptor Homo sapiens 27-30 12727806-4 2003 It has been reported that lung cancer from workers exposed to Cr(VI) has a high percentage of G to T transversion mutations in the non-transcribed strand of the p53 gene, a hallmark of PAH-induced mutation. Polycyclic Aromatic Hydrocarbons 185-188 tumor protein p53 Homo sapiens 161-164 12727806-6 2003 These results raise the possibility that Cr(VI) may enhance PAH binding at the p53 gene in lung tissue. Polycyclic Aromatic Hydrocarbons 60-63 tumor protein p53 Homo sapiens 79-82 12738245-0 2003 Environmental polycyclic aromatic hydrocarbons, benzo(a) pyrene (BaP) and BaP-quinones, enhance IgE-mediated histamine release and IL-4 production in human basophils. Polycyclic Aromatic Hydrocarbons 14-46 interleukin 4 Homo sapiens 131-135 12738245-6 2003 However, several PAHs enhanced histamine release and IL-4 production in response to crosslinking the high-affinity IgE receptor, Fc epsilon RI. Polycyclic Aromatic Hydrocarbons 17-21 interleukin 4 Homo sapiens 53-57 12738245-6 2003 However, several PAHs enhanced histamine release and IL-4 production in response to crosslinking the high-affinity IgE receptor, Fc epsilon RI. Polycyclic Aromatic Hydrocarbons 17-21 Fc epsilon receptor Ia Homo sapiens 129-142 12676598-5 2003 HO-1 expression, a sensitive marker for oxidative stress, is directly correlated with the high organic carbon and polycyclic aromatic hydrocarbon (PAH) content of UFPs. Polycyclic Aromatic Hydrocarbons 114-145 heme oxygenase 1 Homo sapiens 0-4 12468438-10 2003 The CYP1A1*2B allele may predispose to the development of these subgroups of AML by augmented phase 1 metabolism to highly reactive intermediates of CYP1A1 substrates, including polycyclic aromatic hydrocarbons, or by generation of oxidative stress as a metabolic by-product. Polycyclic Aromatic Hydrocarbons 178-210 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-10 12676598-5 2003 HO-1 expression, a sensitive marker for oxidative stress, is directly correlated with the high organic carbon and polycyclic aromatic hydrocarbon (PAH) content of UFPs. Polycyclic Aromatic Hydrocarbons 147-150 heme oxygenase 1 Homo sapiens 0-4 12649394-10 2003 In conclusion, the results of this study support the hypothesis that in SMCs, which are target sites for the development of atherosclerosis, the major bioactivation pathway of BP entails CYP1B1-mediated formation of the 3-OH-BP and BPQ, which are proximate genotoxic metabolites that may in turn get transformed to ultimate DNA-binding metabolites, which may contribute to atherogenesis by PAHs. Polycyclic Aromatic Hydrocarbons 390-394 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 187-193 12615076-1 2003 We have developed a simple system for the sensitive detection and measurement of glutathione S-transferase (GST) activity that detoxifies polycyclic aromatic hydrocarbons using the cultured rat normal liver epithelial cell line, RL34 cells. Polycyclic Aromatic Hydrocarbons 138-170 hematopoietic prostaglandin D synthase Rattus norvegicus 81-106 12615076-1 2003 We have developed a simple system for the sensitive detection and measurement of glutathione S-transferase (GST) activity that detoxifies polycyclic aromatic hydrocarbons using the cultured rat normal liver epithelial cell line, RL34 cells. Polycyclic Aromatic Hydrocarbons 138-170 hematopoietic prostaglandin D synthase Rattus norvegicus 108-111 12775499-9 2003 Although crude analysis suggested that the GSTM1-positive genotype may be associated with lower PAH-DNA levels in Caucasians (but not in African-Americans or Latinos), a formal test for interaction between GSTM1 and ethnicity was not significant. Polycyclic Aromatic Hydrocarbons 96-99 glutathione S-transferase mu 1 Homo sapiens 43-48 12775499-4 2003 Genotypes of glutathione S-transferase M1 and P1 (GSTM1 and GSTP1), enzymes involved in the detoxification of PAH metabolites, were determined by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism, respectively. Polycyclic Aromatic Hydrocarbons 110-113 glutathione S-transferase mu 1 Homo sapiens 13-48 12775499-4 2003 Genotypes of glutathione S-transferase M1 and P1 (GSTM1 and GSTP1), enzymes involved in the detoxification of PAH metabolites, were determined by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism, respectively. Polycyclic Aromatic Hydrocarbons 110-113 glutathione S-transferase mu 1 Homo sapiens 50-55 12775499-4 2003 Genotypes of glutathione S-transferase M1 and P1 (GSTM1 and GSTP1), enzymes involved in the detoxification of PAH metabolites, were determined by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism, respectively. Polycyclic Aromatic Hydrocarbons 110-113 glutathione S-transferase pi 1 Homo sapiens 60-65 12775499-7 2003 Regression analysis of the log-transformed adduct levels confirmed that Caucasian and Latino subjects had lower PAH-DNA adduct levels than African-American subjects, after adjustment for gender, education, alpha-tocopherol and beta-carotene levels, and GSTM1 status. Polycyclic Aromatic Hydrocarbons 112-115 glutathione S-transferase mu 1 Homo sapiens 253-258 12725421-2 2003 We present findings on associations between genetic susceptibility due to inherited polymorphisms of the Phase II detoxification enzyme sulfotransferase 1A1 (SULT1A1), breast cancer risk, and polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Polycyclic Aromatic Hydrocarbons 192-223 sulfotransferase family 1A member 1 Homo sapiens 136-156 12725421-2 2003 We present findings on associations between genetic susceptibility due to inherited polymorphisms of the Phase II detoxification enzyme sulfotransferase 1A1 (SULT1A1), breast cancer risk, and polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Polycyclic Aromatic Hydrocarbons 192-223 sulfotransferase family 1A member 1 Homo sapiens 158-165 12725421-2 2003 We present findings on associations between genetic susceptibility due to inherited polymorphisms of the Phase II detoxification enzyme sulfotransferase 1A1 (SULT1A1), breast cancer risk, and polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Polycyclic Aromatic Hydrocarbons 225-228 sulfotransferase family 1A member 1 Homo sapiens 136-156 12725421-2 2003 We present findings on associations between genetic susceptibility due to inherited polymorphisms of the Phase II detoxification enzyme sulfotransferase 1A1 (SULT1A1), breast cancer risk, and polycyclic aromatic hydrocarbon (PAH)-DNA adducts. Polycyclic Aromatic Hydrocarbons 225-228 sulfotransferase family 1A member 1 Homo sapiens 158-165 12594260-6 2003 Moreover, formation of adherent macrophagic cells was decreased in response to PAHs distinct from BP such as dimethylbenz(a)anthracene and 3-methylcholanthrene, which interact, like BP, with the arylhydrocarbon receptor (AhR) known to mediate many PAH effects. Polycyclic Aromatic Hydrocarbons 79-83 aryl hydrocarbon receptor Homo sapiens 195-219 12594260-6 2003 Moreover, formation of adherent macrophagic cells was decreased in response to PAHs distinct from BP such as dimethylbenz(a)anthracene and 3-methylcholanthrene, which interact, like BP, with the arylhydrocarbon receptor (AhR) known to mediate many PAH effects. Polycyclic Aromatic Hydrocarbons 79-83 aryl hydrocarbon receptor Homo sapiens 221-224 12594260-6 2003 Moreover, formation of adherent macrophagic cells was decreased in response to PAHs distinct from BP such as dimethylbenz(a)anthracene and 3-methylcholanthrene, which interact, like BP, with the arylhydrocarbon receptor (AhR) known to mediate many PAH effects. Polycyclic Aromatic Hydrocarbons 79-82 aryl hydrocarbon receptor Homo sapiens 195-219 12594260-6 2003 Moreover, formation of adherent macrophagic cells was decreased in response to PAHs distinct from BP such as dimethylbenz(a)anthracene and 3-methylcholanthrene, which interact, like BP, with the arylhydrocarbon receptor (AhR) known to mediate many PAH effects. Polycyclic Aromatic Hydrocarbons 79-82 aryl hydrocarbon receptor Homo sapiens 221-224 12594260-9 2003 Overall, these data demonstrate that exposure to PAHs inhibits functional in vitro differentiation of blood monocytes into macrophages, likely through an AhR-dependent mechanism. Polycyclic Aromatic Hydrocarbons 49-53 aryl hydrocarbon receptor Homo sapiens 154-157 12579257-1 2003 Dihydrodiol dehydrogenase (DDH) is one of the major enzymes catabolizing polycyclic aromatic hydrocarbons in the liver. Polycyclic Aromatic Hydrocarbons 73-105 dihydrodiol dehydrogenase Homo sapiens 0-25 12579257-1 2003 Dihydrodiol dehydrogenase (DDH) is one of the major enzymes catabolizing polycyclic aromatic hydrocarbons in the liver. Polycyclic Aromatic Hydrocarbons 73-105 dihydrodiol dehydrogenase Homo sapiens 27-30 12573486-1 2003 Cytochrome P450 1A1 (CYP1A1) is one of the xenobiotic metabolizing enzymes (XMEs), which is induced by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 103-135 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 12573486-1 2003 Cytochrome P450 1A1 (CYP1A1) is one of the xenobiotic metabolizing enzymes (XMEs), which is induced by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 103-135 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 12573486-1 2003 Cytochrome P450 1A1 (CYP1A1) is one of the xenobiotic metabolizing enzymes (XMEs), which is induced by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 137-141 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 12573486-1 2003 Cytochrome P450 1A1 (CYP1A1) is one of the xenobiotic metabolizing enzymes (XMEs), which is induced by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 137-141 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 12628579-0 2003 Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene. Polycyclic Aromatic Hydrocarbons 61-93 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 41-57 12628579-0 2003 Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene. Polycyclic Aromatic Hydrocarbons 61-93 aryl-hydrocarbon receptor Mus musculus 155-179 12628579-1 2003 Tissue-specific induction of mRNA of cytochrome P450 (P450 or CYP) 1A1 and 1B1 by polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) was investigated in wild and arylhydrocarbon receptor (AhR)-deficient C57BL/6J mice. Polycyclic Aromatic Hydrocarbons 82-114 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 54-78 12628579-1 2003 Tissue-specific induction of mRNA of cytochrome P450 (P450 or CYP) 1A1 and 1B1 by polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) was investigated in wild and arylhydrocarbon receptor (AhR)-deficient C57BL/6J mice. Polycyclic Aromatic Hydrocarbons 116-120 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 54-78 12628579-1 2003 Tissue-specific induction of mRNA of cytochrome P450 (P450 or CYP) 1A1 and 1B1 by polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) was investigated in wild and arylhydrocarbon receptor (AhR)-deficient C57BL/6J mice. Polycyclic Aromatic Hydrocarbons 116-120 aryl-hydrocarbon receptor Mus musculus 188-212 12628579-1 2003 Tissue-specific induction of mRNA of cytochrome P450 (P450 or CYP) 1A1 and 1B1 by polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) was investigated in wild and arylhydrocarbon receptor (AhR)-deficient C57BL/6J mice. Polycyclic Aromatic Hydrocarbons 116-120 aryl-hydrocarbon receptor Mus musculus 214-217 12628579-2 2003 Ratios of mRNA expression of CYP1A1 or CYP1B1 over beta-actin were determined and used to compare levels of expression and induction of these P450s by PAHs and PCBs in various organs. Polycyclic Aromatic Hydrocarbons 151-155 actin, beta Mus musculus 51-61 12628579-5 2003 CYP1B1 in the latter two organs was highly induced by PAHs and 3,4,3",4"-tetrachlorobiphenyl in AhR(+/+) mice. Polycyclic Aromatic Hydrocarbons 54-58 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 0-6 12628579-5 2003 CYP1B1 in the latter two organs was highly induced by PAHs and 3,4,3",4"-tetrachlorobiphenyl in AhR(+/+) mice. Polycyclic Aromatic Hydrocarbons 54-58 aryl-hydrocarbon receptor Mus musculus 96-99 12628579-6 2003 The induction of CYP1B1 by PAHs and PCBs was more extensive in organs in which the constitutive expression of CYP1B1 was low. Polycyclic Aromatic Hydrocarbons 27-31 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 17-23 12628579-6 2003 The induction of CYP1B1 by PAHs and PCBs was more extensive in organs in which the constitutive expression of CYP1B1 was low. Polycyclic Aromatic Hydrocarbons 27-31 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 110-116 12628579-8 2003 Liver microsomal xenobiotic oxidation activities were induced by these PAHs and PCBs in male and female AhR(+/+) mice. Polycyclic Aromatic Hydrocarbons 71-75 aryl-hydrocarbon receptor Mus musculus 104-107 12628579-9 2003 These results suggest that CYP1A1 and CYP1B1 are differentially regulated in their expression in extrahepatic organs of mice and could be induced by PAHs and PCBs with different extents of induction depending on the inducers used and the organs examined in AhR(+/+) mice. Polycyclic Aromatic Hydrocarbons 149-153 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 27-33 12628579-9 2003 These results suggest that CYP1A1 and CYP1B1 are differentially regulated in their expression in extrahepatic organs of mice and could be induced by PAHs and PCBs with different extents of induction depending on the inducers used and the organs examined in AhR(+/+) mice. Polycyclic Aromatic Hydrocarbons 149-153 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 38-44 12628579-9 2003 These results suggest that CYP1A1 and CYP1B1 are differentially regulated in their expression in extrahepatic organs of mice and could be induced by PAHs and PCBs with different extents of induction depending on the inducers used and the organs examined in AhR(+/+) mice. Polycyclic Aromatic Hydrocarbons 149-153 aryl-hydrocarbon receptor Mus musculus 257-260 14501033-1 2003 The aryl hydrocarbon receptor (AhR), a ligand activated transcription factor, is the receptor for the polycyclic aromatic hydrocarbons found in tobacco smoke, polychlorinated biphenyls, and the environmental pollutant, dioxin. Polycyclic Aromatic Hydrocarbons 102-134 aryl-hydrocarbon receptor Mus musculus 4-29 12728980-2 2003 The decontamination of a PAH-polluted environment is of importance because some PAHs are toxic, mutagenic, and carcinogenic and therefore are health hazards. Polycyclic Aromatic Hydrocarbons 80-84 phenylalanine hydroxylase Homo sapiens 25-28 12592584-1 2003 OBJECTIVES: Diesel exhaust particles (DEPs) containing polycyclic aromatic hydrocarbons stimulate the formation of IgE in humans following single and acute exposure. Polycyclic Aromatic Hydrocarbons 55-87 immunoglobulin heavy constant epsilon Homo sapiens 115-118 12531201-0 2003 Quantitation of CYP1A1 and 1B1 mRNA in polycyclic aromatic hydrocarbon-treated human T-47D and HepG2 cells by a modified bDNA assay using fluorescence detection. Polycyclic Aromatic Hydrocarbons 39-70 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 16-30 12559965-10 2003 Regulation of adhesion proteins through the AHR pathway may represent a novel mechanism of action by atherogenic polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 113-145 aryl hydrocarbon receptor Rattus norvegicus 44-47 12538356-4 2003 Ultraviolet (UV) light from the sun and polycyclic aromatic hydrocarbons, such as benzo[a]pyrene, are strongly implicated in the spectrum of p53 mutations found in human non-melanoma skin cancers and smoking-associated lung cancers, respectively. Polycyclic Aromatic Hydrocarbons 40-72 tumor protein p53 Homo sapiens 141-144 14501033-1 2003 The aryl hydrocarbon receptor (AhR), a ligand activated transcription factor, is the receptor for the polycyclic aromatic hydrocarbons found in tobacco smoke, polychlorinated biphenyls, and the environmental pollutant, dioxin. Polycyclic Aromatic Hydrocarbons 102-134 aryl-hydrocarbon receptor Mus musculus 31-34 12547635-3 2003 The sediment samples from the upstream area facing Mina Al-Ahmadi refinery to Shuaiba Harbor were heavily polluted with polycyclic aromatic hydrocarbons (PAHs) possibly due to the higher depth in the area created for a navigational channel to the harbor. Polycyclic Aromatic Hydrocarbons 120-152 ribosomal oxygenase 2 Homo sapiens 51-55 12542289-7 2003 The PAH compounds sampled with SPMDs were mainly associated with gaseous PAHs, while both gas phase and particle-bound PAHs were detected in the plant samples. Polycyclic Aromatic Hydrocarbons 73-77 phenylalanine hydroxylase Homo sapiens 4-7 12683236-8 2003 To clarify the role of Ah-receptor in PAH action on GJIC, the effect of 2,3,7,8-tetrachlorodibezdioxin, a specific ligand of Ah-receptor was studied, which appeared to be insignificant. Polycyclic Aromatic Hydrocarbons 38-41 aryl hydrocarbon receptor Homo sapiens 23-34 12455047-0 2003 Polycyclic aromatic hydrocarbon-inducible DNA adducts: evidence by 32P-postlabeling and use of knockout mice for Ah receptor-independent mechanisms of metabolic activation in vivo. Polycyclic Aromatic Hydrocarbons 0-31 aryl-hydrocarbon receptor Mus musculus 113-124 12455047-3 2003 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons 108-112 aryl-hydrocarbon receptor Mus musculus 4-15 12455047-3 2003 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons 108-112 aryl-hydrocarbon receptor Mus musculus 17-20 12455047-3 2003 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons 108-112 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 64-68 12455047-3 2003 The Ah receptor (AHR) plays a critical role in the induction of CYP1 enzymes (i.e., CYP1A1, 1A2 and 1B1) by PAHs such as benzo[a]pyrene (BP) and 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons 108-112 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 84-90 12455047-4 2003 In our investigation, we tested the hypothesis that AHR-null animals are less susceptible to PAH-induced DNA adduct formation than wild-type animals. Polycyclic Aromatic Hydrocarbons 93-96 aryl-hydrocarbon receptor Mus musculus 52-55 12455047-9 2003 CYP1B1 expression was also induced, albeit to a lesser extent by the PAH MC, but not BP, in the wild-type animals. Polycyclic Aromatic Hydrocarbons 69-72 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 0-6 12455047-10 2003 In conclusion, these results demonstrate the existence of AHR- and CYP1A1-independent mechanisms of PAH metabolic activation in mouse liver, a phenomenon that may have important implications for PAH-mediated carcinogenesis. Polycyclic Aromatic Hydrocarbons 100-103 aryl-hydrocarbon receptor Mus musculus 58-61 12455047-10 2003 In conclusion, these results demonstrate the existence of AHR- and CYP1A1-independent mechanisms of PAH metabolic activation in mouse liver, a phenomenon that may have important implications for PAH-mediated carcinogenesis. Polycyclic Aromatic Hydrocarbons 100-103 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 67-73 12455047-10 2003 In conclusion, these results demonstrate the existence of AHR- and CYP1A1-independent mechanisms of PAH metabolic activation in mouse liver, a phenomenon that may have important implications for PAH-mediated carcinogenesis. Polycyclic Aromatic Hydrocarbons 195-198 aryl-hydrocarbon receptor Mus musculus 58-61 12455047-10 2003 In conclusion, these results demonstrate the existence of AHR- and CYP1A1-independent mechanisms of PAH metabolic activation in mouse liver, a phenomenon that may have important implications for PAH-mediated carcinogenesis. Polycyclic Aromatic Hydrocarbons 195-198 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 67-73 12490585-0 2003 Blockage of multidrug resistance-associated proteins potentiates the inhibitory effects of arsenic trioxide on CYP1A1 induction by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 131-163 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 111-117 12490585-2 2003 In the present study, we investigated the effects of arsenic trioxide (As2O3), recently used as an anticancer drug, on the expression of human cytochrome P450 (P450) 1A1, which bioactivates polycyclic aromatic hydrocarbons into mutagenic metabolites. Polycyclic Aromatic Hydrocarbons 190-222 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 143-169 12441364-0 2002 Modulation of estrogen receptor-dependent reporter construct activation and G0/G1-S-phase transition by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells. Polycyclic Aromatic Hydrocarbons 104-136 estrogen receptor 1 Homo sapiens 14-31 12441364-3 2002 In this study, several other PAHs, including fluorene, fluoranthene, pyrene, chrysene, phenanthrene and anthracene, were found to act as very weak inducers of ER-mediated activity in the MCF-7 cell line stably transfected with a luciferase reporter gene. Polycyclic Aromatic Hydrocarbons 29-33 estrogen receptor 1 Homo sapiens 159-161 12552997-1 2002 N-acetyltransferase-2 (NAT-2) and Glutathione-S-transferase M1 and T1 (GSTM1 and GSTT1) polymorphism have been implicated in the detoxification of urothelial carcinogens, such as arylamines and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 194-226 N-acetyltransferase 2 Homo sapiens 0-21 12552997-1 2002 N-acetyltransferase-2 (NAT-2) and Glutathione-S-transferase M1 and T1 (GSTM1 and GSTT1) polymorphism have been implicated in the detoxification of urothelial carcinogens, such as arylamines and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 194-226 glutathione S-transferase mu 1 Homo sapiens 34-69 12552997-1 2002 N-acetyltransferase-2 (NAT-2) and Glutathione-S-transferase M1 and T1 (GSTM1 and GSTT1) polymorphism have been implicated in the detoxification of urothelial carcinogens, such as arylamines and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 194-226 glutathione S-transferase mu 1 Homo sapiens 71-76 12552997-1 2002 N-acetyltransferase-2 (NAT-2) and Glutathione-S-transferase M1 and T1 (GSTM1 and GSTT1) polymorphism have been implicated in the detoxification of urothelial carcinogens, such as arylamines and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 194-226 glutathione S-transferase theta 1 Homo sapiens 81-86 12619281-2 2002 This paper dealed with the effects of some polycyclic aromatic hydrocarbons (PAHs) and two kinds of monoaromatics on the degradation of BaP. Polycyclic Aromatic Hydrocarbons 43-75 prohibitin 2 Homo sapiens 136-139 12619281-2 2002 This paper dealed with the effects of some polycyclic aromatic hydrocarbons (PAHs) and two kinds of monoaromatics on the degradation of BaP. Polycyclic Aromatic Hydrocarbons 77-81 prohibitin 2 Homo sapiens 136-139 12379456-1 2002 The high frequency of G-->T transversions in the p53 gene is a distinctive feature of lung cancer patients with a smoking history and is commonly believed to reflect the direct mutagenic signature of polycyclic aromatic hydrocarbon (PAH) adducts along the gene. Polycyclic Aromatic Hydrocarbons 203-234 tumor protein p53 Homo sapiens 52-55 12379456-1 2002 The high frequency of G-->T transversions in the p53 gene is a distinctive feature of lung cancer patients with a smoking history and is commonly believed to reflect the direct mutagenic signature of polycyclic aromatic hydrocarbon (PAH) adducts along the gene. Polycyclic Aromatic Hydrocarbons 236-239 tumor protein p53 Homo sapiens 52-55 12163478-0 2002 Diesel exhaust particle extracts and associated polycyclic aromatic hydrocarbons inhibit Cox-2-dependent prostaglandin synthesis in murine macrophages and fibroblasts. Polycyclic Aromatic Hydrocarbons 48-80 prostaglandin-endoperoxide synthase 2 Mus musculus 89-94 12376472-1 2002 DNA damage from polycyclic aromatic hydrocarbons (PAH) and other aromatic/hydrophobic compounds has been implicated in case-control studies as a risk factor for lung cancer, as have common polymorphisms in the glutathione S-transferase (GST) genes involved in carcinogen detoxification. Polycyclic Aromatic Hydrocarbons 16-48 glutathione S-transferase Nicotiana tabacum 210-235 12376472-1 2002 DNA damage from polycyclic aromatic hydrocarbons (PAH) and other aromatic/hydrophobic compounds has been implicated in case-control studies as a risk factor for lung cancer, as have common polymorphisms in the glutathione S-transferase (GST) genes involved in carcinogen detoxification. Polycyclic Aromatic Hydrocarbons 16-48 glutathione S-transferase Nicotiana tabacum 237-240 12376472-1 2002 DNA damage from polycyclic aromatic hydrocarbons (PAH) and other aromatic/hydrophobic compounds has been implicated in case-control studies as a risk factor for lung cancer, as have common polymorphisms in the glutathione S-transferase (GST) genes involved in carcinogen detoxification. Polycyclic Aromatic Hydrocarbons 50-53 glutathione S-transferase Nicotiana tabacum 210-235 12376472-1 2002 DNA damage from polycyclic aromatic hydrocarbons (PAH) and other aromatic/hydrophobic compounds has been implicated in case-control studies as a risk factor for lung cancer, as have common polymorphisms in the glutathione S-transferase (GST) genes involved in carcinogen detoxification. Polycyclic Aromatic Hydrocarbons 50-53 glutathione S-transferase Nicotiana tabacum 237-240 12237110-2 2002 Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) leads to induction of CYP1A1 via AhR pathway. Polycyclic Aromatic Hydrocarbons 45-77 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 107-113 12369894-9 2002 For instance, the expression of CYP1 genes can be induced via the aryl hydrocarbon receptor (AhR) which dimerizes with the AhR nuclear translocator (ARNT), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 176-207 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-36 12369894-9 2002 For instance, the expression of CYP1 genes can be induced via the aryl hydrocarbon receptor (AhR) which dimerizes with the AhR nuclear translocator (ARNT), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 176-207 aryl hydrocarbon receptor Homo sapiens 66-91 12369894-9 2002 For instance, the expression of CYP1 genes can be induced via the aryl hydrocarbon receptor (AhR) which dimerizes with the AhR nuclear translocator (ARNT), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 176-207 aryl hydrocarbon receptor Homo sapiens 93-96 12369894-9 2002 For instance, the expression of CYP1 genes can be induced via the aryl hydrocarbon receptor (AhR) which dimerizes with the AhR nuclear translocator (ARNT), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 176-207 aryl hydrocarbon receptor nuclear translocator Homo sapiens 123-147 12369894-9 2002 For instance, the expression of CYP1 genes can be induced via the aryl hydrocarbon receptor (AhR) which dimerizes with the AhR nuclear translocator (ARNT), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 176-207 aryl hydrocarbon receptor nuclear translocator Homo sapiens 149-153 12369894-9 2002 For instance, the expression of CYP1 genes can be induced via the aryl hydrocarbon receptor (AhR) which dimerizes with the AhR nuclear translocator (ARNT), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 209-213 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-36 12369894-9 2002 For instance, the expression of CYP1 genes can be induced via the aryl hydrocarbon receptor (AhR) which dimerizes with the AhR nuclear translocator (ARNT), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 209-213 aryl hydrocarbon receptor Homo sapiens 66-91 12369894-9 2002 For instance, the expression of CYP1 genes can be induced via the aryl hydrocarbon receptor (AhR) which dimerizes with the AhR nuclear translocator (ARNT), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 209-213 aryl hydrocarbon receptor Homo sapiens 93-96 12369894-9 2002 For instance, the expression of CYP1 genes can be induced via the aryl hydrocarbon receptor (AhR) which dimerizes with the AhR nuclear translocator (ARNT), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 209-213 aryl hydrocarbon receptor nuclear translocator Homo sapiens 123-147 12369894-9 2002 For instance, the expression of CYP1 genes can be induced via the aryl hydrocarbon receptor (AhR) which dimerizes with the AhR nuclear translocator (ARNT), in response to many polycyclic aromatic hydrocarbon (PAHs). Polycyclic Aromatic Hydrocarbons 209-213 aryl hydrocarbon receptor nuclear translocator Homo sapiens 149-153 12237110-2 2002 Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) leads to induction of CYP1A1 via AhR pathway. Polycyclic Aromatic Hydrocarbons 45-77 aryl hydrocarbon receptor Homo sapiens 118-121 12237110-2 2002 Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) leads to induction of CYP1A1 via AhR pathway. Polycyclic Aromatic Hydrocarbons 79-83 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 107-113 12237110-2 2002 Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) leads to induction of CYP1A1 via AhR pathway. Polycyclic Aromatic Hydrocarbons 79-83 aryl hydrocarbon receptor Homo sapiens 118-121 12237110-7 2002 FBS potentiation of CYP1A1 PAH-mediated induction was related to a significant increase of single strand breaks of DNA as compared to a single 3-MC treatment. Polycyclic Aromatic Hydrocarbons 27-30 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 12398325-1 2002 Cytochrome P450 1B1 (CYP1B1) is induced through the Ah receptor and is involved in the activation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 101-133 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 12398325-1 2002 Cytochrome P450 1B1 (CYP1B1) is induced through the Ah receptor and is involved in the activation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 101-133 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 12398325-1 2002 Cytochrome P450 1B1 (CYP1B1) is induced through the Ah receptor and is involved in the activation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 101-133 aryl hydrocarbon receptor Homo sapiens 52-63 12398325-1 2002 Cytochrome P450 1B1 (CYP1B1) is induced through the Ah receptor and is involved in the activation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 135-139 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 12398325-1 2002 Cytochrome P450 1B1 (CYP1B1) is induced through the Ah receptor and is involved in the activation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 135-139 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 12398325-1 2002 Cytochrome P450 1B1 (CYP1B1) is induced through the Ah receptor and is involved in the activation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 135-139 aryl hydrocarbon receptor Homo sapiens 52-63 12393170-0 2002 Polycyclic aromatic hydrocarbons induce IL-8 expression through nuclear factor kappaB activation in A549 cell line. Polycyclic Aromatic Hydrocarbons 0-32 C-X-C motif chemokine ligand 8 Homo sapiens 40-44 12393170-5 2002 However, it is unknown whether polycyclic aromatic hydrocarbons (PAH), mainly existed in most airborne particulates, can separately induce IL-8 expression. Polycyclic Aromatic Hydrocarbons 31-63 C-X-C motif chemokine ligand 8 Homo sapiens 139-143 12393170-5 2002 However, it is unknown whether polycyclic aromatic hydrocarbons (PAH), mainly existed in most airborne particulates, can separately induce IL-8 expression. Polycyclic Aromatic Hydrocarbons 65-68 C-X-C motif chemokine ligand 8 Homo sapiens 139-143 12393170-6 2002 In the present study, we investigated the effect of benzo(a)pyrene (B[a]P) and 1-nitropyrene (1-NP), two representative PAH, on IL-8 expression using ELISA and Northern blot analysis. Polycyclic Aromatic Hydrocarbons 120-123 C-X-C motif chemokine ligand 8 Homo sapiens 128-132 12393170-8 2002 We have assessed the effect of adenovirus-mediated overexpression of the NF-kappaB inhibitor, IkappaBalpha on PAH-induced IL-8 expression in A549 cell line. Polycyclic Aromatic Hydrocarbons 110-113 NFKB inhibitor alpha Homo sapiens 94-106 12393170-8 2002 We have assessed the effect of adenovirus-mediated overexpression of the NF-kappaB inhibitor, IkappaBalpha on PAH-induced IL-8 expression in A549 cell line. Polycyclic Aromatic Hydrocarbons 110-113 C-X-C motif chemokine ligand 8 Homo sapiens 122-126 12393170-12 2002 This suggests that PAH-induced IL-8 gene regulation may be mediated by NF-kappaB. Polycyclic Aromatic Hydrocarbons 19-22 C-X-C motif chemokine ligand 8 Homo sapiens 31-35 12393170-13 2002 These data indicate that PAH alone, either B[a]P or 1-NP, is sufficient to stimulate NF-kappaB activation and IL-8 transcription. Polycyclic Aromatic Hydrocarbons 25-28 C-X-C motif chemokine ligand 8 Homo sapiens 110-114 12203118-1 2002 The arylhydrocarbon receptor (AhR) was initially identified as a member of the adaptive metabolic and toxic response pathway to polycyclic aromatic hydrocarbons and to halogenated dibenzo-p-dioxins and dibenzofurans. Polycyclic Aromatic Hydrocarbons 128-160 aryl hydrocarbon receptor Homo sapiens 4-28 12203118-1 2002 The arylhydrocarbon receptor (AhR) was initially identified as a member of the adaptive metabolic and toxic response pathway to polycyclic aromatic hydrocarbons and to halogenated dibenzo-p-dioxins and dibenzofurans. Polycyclic Aromatic Hydrocarbons 128-160 aryl hydrocarbon receptor Homo sapiens 30-33 12378791-1 2002 Several ethnic groups have been genotyped for polymorphisms at the CYP1A1 gene locus that encodes the enzyme that catalyzes the initial step in the metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 162-194 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 67-73 12243508-0 2002 Polymorphisms in the DNA repair enzyme XPD are associated with increased levels of PAH-DNA adducts in a case-control study of breast cancer. Polycyclic Aromatic Hydrocarbons 83-86 ERCC excision repair 2, TFIIH core complex helicase subunit Homo sapiens 39-42 12243508-6 2002 XPD polymorphisms at codons 312 and 751 were associated with higher levels of PAH-DNA in tumor tissue from breast cancer cases. Polycyclic Aromatic Hydrocarbons 78-81 ERCC excision repair 2, TFIIH core complex helicase subunit Homo sapiens 0-3 12243508-7 2002 Subjects with an Asp/Asn or Asn/Asn polymorphic genotype in codon 312 of XPD had elevated levels of PAH-DNA adducts compared to subjects with the Asp/Asp genotype (0.55 optical density (OD) v.s. Polycyclic Aromatic Hydrocarbons 100-103 ERCC excision repair 2, TFIIH core complex helicase subunit Homo sapiens 73-76 12229918-1 2002 A fluorometric screening method was used to estimate total polycyclic aromatic hydrocarbon (t-PAH) concentrations in sediments collected from the St. Louis River Area of Concern (AOC) in northeastern Minnesota. Polycyclic Aromatic Hydrocarbons 59-90 phenylalanine hydroxylase Homo sapiens 94-97 12205049-0 2002 Polycyclic aromatic hydrocarbons present in cigarette smoke cause endothelial cell apoptosis by a phospholipase A2-dependent mechanism. Polycyclic Aromatic Hydrocarbons 0-32 phospholipase A2 group IB Homo sapiens 98-114 12205049-4 2002 The purpose of this study was to investigate the effects of polycyclic aromatic hydrocarbons contained in cigarette smoke on phospholipase A2 (PLA2) activity and apoptosis of human coronary artery endothelial cells. Polycyclic Aromatic Hydrocarbons 60-92 phospholipase A2 group IB Homo sapiens 125-141 12205049-4 2002 The purpose of this study was to investigate the effects of polycyclic aromatic hydrocarbons contained in cigarette smoke on phospholipase A2 (PLA2) activity and apoptosis of human coronary artery endothelial cells. Polycyclic Aromatic Hydrocarbons 60-92 phospholipase A2 group IB Homo sapiens 143-147 12007870-0 2002 The influence of sediment and feeding on the elimination of polycyclic aromatic hydrocarbons in the freshwater amphipod, Diporeia spp. Polycyclic Aromatic Hydrocarbons 60-92 histocompatibility minor 13 Homo sapiens 130-133 12398325-4 2002 The average level of the CYP1B1 mRNA in workers at the top work site, where the PAH exposure level from the coke ovens was highest, was significantly higher than in workers at the middle site (P<0.01) or the controls (P=0.02). Polycyclic Aromatic Hydrocarbons 80-83 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 25-31 12398325-7 2002 Our preliminary study suggests that PAH exposure in coke ovens and smoking maybe associated with CYP1B1 mRNA levels in peripheral blood cells although mRNA is generally unstable and could be expressed following exposure to other agents. Polycyclic Aromatic Hydrocarbons 36-39 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 97-103 12007870-4 2002 The elimination of selected PAH congeners by Diporeia spp. Polycyclic Aromatic Hydrocarbons 28-31 histocompatibility minor 13 Homo sapiens 54-57 11948486-5 2002 PAHs are metabolically activated by phase I enzymes, including CYP1A1, into electrophilic reactants (diol epoxides), which covalently bind to DNA to form adducts. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 63-69 12224597-8 2002 Since CYP1A1/1B1 were responsible for the biotransformation of polycyclic aromatic hydrocarbons, baicalein also demonstrated its ability to reduce DMBA-DNA adduct formation in MCF-7 cells. Polycyclic Aromatic Hydrocarbons 63-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 6-16 12379884-9 2002 Recent studies have indicated that there is a strong coincidence of G to T transversion hotspots in lung cancers and sites of preferential formation of PAH adducts along the p53 gene. Polycyclic Aromatic Hydrocarbons 152-155 tumor protein p53 Homo sapiens 174-177 12110274-1 2002 The rainbow trout cytochrome P4501A gene subfamily consists of two members, CYP1A1 and CYP1A3, which are induced by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 150-154 cytochrome P450 1A3 Oncorhynchus mykiss 87-93 12107650-0 2002 Induction of cytochrome P450 1A1 in multiple organs of minipigs after oral exposure to soils contaminated with polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 111-143 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-32 12107650-0 2002 Induction of cytochrome P450 1A1 in multiple organs of minipigs after oral exposure to soils contaminated with polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 145-148 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-32 12107650-2 2002 The effects of three orally administered soils containing polycyclic aromatic hydrocarbons (PAH) on the expression pattern of the cytochrome P450 enzyme CYP1A1 in various organs have been analyzed. Polycyclic Aromatic Hydrocarbons 58-90 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 153-159 12107650-2 2002 The effects of three orally administered soils containing polycyclic aromatic hydrocarbons (PAH) on the expression pattern of the cytochrome P450 enzyme CYP1A1 in various organs have been analyzed. Polycyclic Aromatic Hydrocarbons 92-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 153-159 12107650-8 2002 As is shown in one case, impairment of CYP1A1 induction in the liver and thus breakdown of its PAH-metabolizing activity appears to have no effect on induced CYP1A1 levels in other organs. Polycyclic Aromatic Hydrocarbons 95-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 39-45 12107650-10 2002 Induced duodenal CYP1A1 activities obtained in minipigs by oral exposure to PAH largely exceed maximal duodenal activities so far observed in rats. Polycyclic Aromatic Hydrocarbons 76-79 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 17-23 12052463-2 2002 Benzo(a)pyrene (BaP) and 7,12-dimethylbenz(a)anthracene (DMBA) are polycyclic aromatic hydrocarbons (PAHs) found in the tar fraction of cigarette smoke, as well as in car exhaust and furnace gases. Polycyclic Aromatic Hydrocarbons 67-99 prohibitin 2 Rattus norvegicus 16-19 12052463-2 2002 Benzo(a)pyrene (BaP) and 7,12-dimethylbenz(a)anthracene (DMBA) are polycyclic aromatic hydrocarbons (PAHs) found in the tar fraction of cigarette smoke, as well as in car exhaust and furnace gases. Polycyclic Aromatic Hydrocarbons 101-105 prohibitin 2 Rattus norvegicus 16-19 12034312-1 2002 Co-exposures to complex mixtures of arsenic and polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) are common in the environment. Polycyclic Aromatic Hydrocarbons 48-80 prohibitin 2 Mus musculus 105-108 12034316-1 2002 The aim of this study was to use DNA adducts levels, detected by 32P-postlabelling, as a biomarker to assess human exposure to polycyclic aromatic hydrocarbons (PAHs) from a coke oven plant and explore the possible association between CYP1A1 MspI, GSTP1, GSTM1 and GSTT1 genotypes, and smoking status on bulky DNA adduct formation. Polycyclic Aromatic Hydrocarbons 161-165 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 235-241 12034316-1 2002 The aim of this study was to use DNA adducts levels, detected by 32P-postlabelling, as a biomarker to assess human exposure to polycyclic aromatic hydrocarbons (PAHs) from a coke oven plant and explore the possible association between CYP1A1 MspI, GSTP1, GSTM1 and GSTT1 genotypes, and smoking status on bulky DNA adduct formation. Polycyclic Aromatic Hydrocarbons 161-165 glutathione S-transferase pi 1 Homo sapiens 248-253 12034316-1 2002 The aim of this study was to use DNA adducts levels, detected by 32P-postlabelling, as a biomarker to assess human exposure to polycyclic aromatic hydrocarbons (PAHs) from a coke oven plant and explore the possible association between CYP1A1 MspI, GSTP1, GSTM1 and GSTT1 genotypes, and smoking status on bulky DNA adduct formation. Polycyclic Aromatic Hydrocarbons 161-165 glutathione S-transferase mu 1 Homo sapiens 255-260 12034316-1 2002 The aim of this study was to use DNA adducts levels, detected by 32P-postlabelling, as a biomarker to assess human exposure to polycyclic aromatic hydrocarbons (PAHs) from a coke oven plant and explore the possible association between CYP1A1 MspI, GSTP1, GSTM1 and GSTT1 genotypes, and smoking status on bulky DNA adduct formation. Polycyclic Aromatic Hydrocarbons 161-165 glutathione S-transferase theta 1 Homo sapiens 265-270 11948486-8 2002 Subjects were also genotyped for polymorphism in several genes involved in the metabolism of PAH, including GSTM1 and GSTP1. Polycyclic Aromatic Hydrocarbons 93-96 glutathione S-transferase mu 1 Homo sapiens 108-113 11956619-3 2002 Because DDH could metabolize polycyclic aromatic hydrocarbons (PAH) in the liver, DDH overexpression in NSCLC would suggest an association with carcinogenesis and disease progression. Polycyclic Aromatic Hydrocarbons 29-61 dihydrodiol dehydrogenase Homo sapiens 8-11 11956619-3 2002 Because DDH could metabolize polycyclic aromatic hydrocarbons (PAH) in the liver, DDH overexpression in NSCLC would suggest an association with carcinogenesis and disease progression. Polycyclic Aromatic Hydrocarbons 29-61 dihydrodiol dehydrogenase Homo sapiens 82-85 11956619-3 2002 Because DDH could metabolize polycyclic aromatic hydrocarbons (PAH) in the liver, DDH overexpression in NSCLC would suggest an association with carcinogenesis and disease progression. Polycyclic Aromatic Hydrocarbons 63-66 dihydrodiol dehydrogenase Homo sapiens 8-11 11852118-8 2002 The presented data suggest that solvents such as benzene, styrene and PAHs activate peripheral lymphocytes, and cause changes in the incidence of CD25+/CD4+ T lymphocytes that may represent a distinct subset of immune-regulatory T cells. Polycyclic Aromatic Hydrocarbons 70-74 interleukin 2 receptor subunit alpha Homo sapiens 146-150 11852118-8 2002 The presented data suggest that solvents such as benzene, styrene and PAHs activate peripheral lymphocytes, and cause changes in the incidence of CD25+/CD4+ T lymphocytes that may represent a distinct subset of immune-regulatory T cells. Polycyclic Aromatic Hydrocarbons 70-74 CD4 molecule Homo sapiens 152-155 11879972-1 2002 The behavioral changes caused by benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH) compound, were monitored, and also its metabolite levels in cerebellum and cortex were measured in BaP treated rats to see if any relationship existed between these two aspects. Polycyclic Aromatic Hydrocarbons 90-93 prohibitin 2 Rattus norvegicus 49-52 11967619-2 2002 Cytochrome P450 (Cyp) 1A1 can be induced by several kinds of PAH and produce ROS. Polycyclic Aromatic Hydrocarbons 61-64 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-25 11952781-2 2002 Human cytochrome P4501A1 (CYP1A1) is one of the key enzymes in the bioactivation of environmental pollutants such as benzo[a]pyrene (B[a]P) and other polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 150-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 6-24 11952781-2 2002 Human cytochrome P4501A1 (CYP1A1) is one of the key enzymes in the bioactivation of environmental pollutants such as benzo[a]pyrene (B[a]P) and other polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 150-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 26-32 11884429-4 2002 Besides BP, PAHs such as dimethylbenz(a)anthracene and benzanthracene also strongly altered CD1a levels. Polycyclic Aromatic Hydrocarbons 12-16 CD1a molecule Homo sapiens 92-96 11965528-12 2002 These results confirm the common practice to use BaP as marker compound for the PAH exposure in ambient air. Polycyclic Aromatic Hydrocarbons 80-83 prohibitin 2 Homo sapiens 49-52 11914776-0 2002 Differential induction of CYP1A1 in duodenum, liver and kidney of rats after oral intake of soil containing polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 108-140 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 26-32 11914776-8 2002 In accordance with previous results, there is a sigmoidal dose-response relationship between induction of hepatic CYP1A1 levels and the soil contamination with higher condensates of PAH. Polycyclic Aromatic Hydrocarbons 182-185 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 114-120 11914776-13 2002 Hence, oral PAH intake leads to differential induction patterns of CYP1A1 in duodenum, liver and kidney of rats. Polycyclic Aromatic Hydrocarbons 12-15 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 67-73 11936216-0 2002 Influence of polymorphism of GSTM1 gene on association between glycophorin a mutant frequency and urinary PAH metabolites in incineration workers. Polycyclic Aromatic Hydrocarbons 106-109 glutathione S-transferase mu 1 Homo sapiens 29-34 11936216-0 2002 Influence of polymorphism of GSTM1 gene on association between glycophorin a mutant frequency and urinary PAH metabolites in incineration workers. Polycyclic Aromatic Hydrocarbons 106-109 glycophorin A (MNS blood group) Homo sapiens 63-76 11815259-0 2002 Influence of GSTM1 genotype on association between aromatic DNA adducts and urinary PAH metabolites in incineration workers. Polycyclic Aromatic Hydrocarbons 84-87 glutathione S-transferase mu 1 Homo sapiens 13-18 11815259-15 2002 Our results suggest that the significant increase in urinary 1-OHPG in the exposed workers is due to higher prevalence of smokers among them, and that the association between urinary PAH metabolites and aromatic DNA adducts in workers of industrial waste handling may be modulated by GSTM1 genotype. Polycyclic Aromatic Hydrocarbons 183-186 glutathione S-transferase mu 1 Homo sapiens 284-289 11749126-1 2001 Certainpolynuclear aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (BaP) induce CYP1A-dependent enzyme activities. Polycyclic Aromatic Hydrocarbons 42-46 cytochrome P450 1A1 Fundulus heteroclitus 84-89 11944795-5 2002 The profiles of PAH/BaP at the measurement sites showed that the main source of PAHs in spring and summer was traffic while a substantial amount of autumn and winter PAHs, besides traffic, came from heating. Polycyclic Aromatic Hydrocarbons 80-84 phenylalanine hydroxylase Homo sapiens 16-19 12369945-1 2002 Binding of ligands such as polycyclic aromatic hydrocarbons to the Aryl hydrocarbon Receptor (AhR) and the sequence of events leading to induction of xenobiotic-metabolising enzymes such as the cytochrome P450 isoform 1A1 and subsequent generation of DNA adducts is historically associated with the process of chemical carcinogenesis. Polycyclic Aromatic Hydrocarbons 27-59 aryl hydrocarbon receptor Homo sapiens 67-92 12369945-1 2002 Binding of ligands such as polycyclic aromatic hydrocarbons to the Aryl hydrocarbon Receptor (AhR) and the sequence of events leading to induction of xenobiotic-metabolising enzymes such as the cytochrome P450 isoform 1A1 and subsequent generation of DNA adducts is historically associated with the process of chemical carcinogenesis. Polycyclic Aromatic Hydrocarbons 27-59 aryl hydrocarbon receptor Homo sapiens 94-97 11921194-4 2002 We report that benzo[a]pyrene (B[a]P), selected as a prototype PAH, disrupts BRCA-1 transcription in estrogen receptor (ER)-positive but not ER-negative breast cancer cells. Polycyclic Aromatic Hydrocarbons 63-66 BRCA1 DNA repair associated Homo sapiens 77-83 11849049-14 2002 These data demonstrate the role of P450 1a1 and 1b1 in the metabolic activation of DMBA in mouse epidermis and provide a mechanistic explanation for the differential effects of naturally occurring furanocoumarins (and 7,8-BF) on polycyclic aromatic hydrocarbon skin carcinogenesis. Polycyclic Aromatic Hydrocarbons 229-260 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 35-51 11796517-3 2002 Furthermore, the AHR is a well established receptor for polycyclic aromatic hydrocarbons (PAHs), a class of ubiquitous environmental chemicals known to cause the death of female germ cells in fetal life. Polycyclic Aromatic Hydrocarbons 56-88 aryl-hydrocarbon receptor Mus musculus 17-20 11796517-3 2002 Furthermore, the AHR is a well established receptor for polycyclic aromatic hydrocarbons (PAHs), a class of ubiquitous environmental chemicals known to cause the death of female germ cells in fetal life. Polycyclic Aromatic Hydrocarbons 90-94 aryl-hydrocarbon receptor Mus musculus 17-20 11796517-6 2002 Embryonic d 13.5 murine fetal ovaries cultured in the presence of PAHs exhibited a high level of germ cell loss via apoptosis that was prevented by the selective AHR antagonist, alpha-napthoflavone (ANF). Polycyclic Aromatic Hydrocarbons 66-70 aryl-hydrocarbon receptor Mus musculus 162-165 11796517-9 2002 We conclude that a central role exists for the AHR in transducing the actions of PAHs in fetal ovarian germ cells, and that the proapoptotic Bcl-2 family member, Bax, is a required mediator of PAH-induced oocyte loss in female fetuses exposed to PAHs in utero. Polycyclic Aromatic Hydrocarbons 81-84 aryl-hydrocarbon receptor Mus musculus 47-50 11796517-9 2002 We conclude that a central role exists for the AHR in transducing the actions of PAHs in fetal ovarian germ cells, and that the proapoptotic Bcl-2 family member, Bax, is a required mediator of PAH-induced oocyte loss in female fetuses exposed to PAHs in utero. Polycyclic Aromatic Hydrocarbons 81-84 BCL2-associated X protein Mus musculus 162-165 11796517-9 2002 We conclude that a central role exists for the AHR in transducing the actions of PAHs in fetal ovarian germ cells, and that the proapoptotic Bcl-2 family member, Bax, is a required mediator of PAH-induced oocyte loss in female fetuses exposed to PAHs in utero. Polycyclic Aromatic Hydrocarbons 81-85 aryl-hydrocarbon receptor Mus musculus 47-50 11812924-2 2002 Although halogenated and polycyclic aromatic hydrocarbons (HAHs and PAHs, respectively) represent the highest affinity and most toxic ligands, recent studies have demonstrated that the AhR can be activated by chemicals with structures distinctly different from HAHs/PAHs. Polycyclic Aromatic Hydrocarbons 25-57 aryl-hydrocarbon receptor Mus musculus 185-188 11812924-3 2002 In order to identify and characterize novel AhR ligands, we developed a rapid and inexpensive high-throughput screening bioassay based on the ability of AhR agonists to induce an HAH/PAH-responsive, enhanced green fluorescent protein (EGFP) reporter gene in a stably transfected mouse hepatoma (Hepa1c1c7) cell line. Polycyclic Aromatic Hydrocarbons 183-186 aryl-hydrocarbon receptor Mus musculus 44-47 11812924-3 2002 In order to identify and characterize novel AhR ligands, we developed a rapid and inexpensive high-throughput screening bioassay based on the ability of AhR agonists to induce an HAH/PAH-responsive, enhanced green fluorescent protein (EGFP) reporter gene in a stably transfected mouse hepatoma (Hepa1c1c7) cell line. Polycyclic Aromatic Hydrocarbons 183-186 aryl-hydrocarbon receptor Mus musculus 153-156 11790108-1 2002 The Ah receptor is a ligand-dependent transcription factor that mediates the biological and toxic effects of polycyclic aromatic hydrocarbons and halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin). Polycyclic Aromatic Hydrocarbons 109-141 aryl-hydrocarbon receptor Mus musculus 4-15 11808735-0 2002 Study of ground state EDA complex formation between [70]fullerene and a series of polynuclear aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 82-115 ectodysplasin A Homo sapiens 22-25 12587778-0 2002 Immunosuppressive effect of polycyclic aromatic hydrocarbons by induction of apoptosis of pre-B lymphocytes of bone marrow. Polycyclic Aromatic Hydrocarbons 28-60 prolactin regulatory element binding Homo sapiens 90-95 12587778-4 2002 It has been proved that the effect of PAH is caused mostly by the following mechanisms: enzymatic induction by the way of activation of AhR (Aromatic hydrocarbon Receptor); alteration of cellular DNA; development of oxidative stress; increase in the concentration of intercellular calcium and decline of activity of NF-kappaB (Nuclear Factor-kappa B). Polycyclic Aromatic Hydrocarbons 38-41 aryl hydrocarbon receptor Homo sapiens 136-139 12587778-4 2002 It has been proved that the effect of PAH is caused mostly by the following mechanisms: enzymatic induction by the way of activation of AhR (Aromatic hydrocarbon Receptor); alteration of cellular DNA; development of oxidative stress; increase in the concentration of intercellular calcium and decline of activity of NF-kappaB (Nuclear Factor-kappa B). Polycyclic Aromatic Hydrocarbons 38-41 aryl hydrocarbon receptor Homo sapiens 141-170 12587778-4 2002 It has been proved that the effect of PAH is caused mostly by the following mechanisms: enzymatic induction by the way of activation of AhR (Aromatic hydrocarbon Receptor); alteration of cellular DNA; development of oxidative stress; increase in the concentration of intercellular calcium and decline of activity of NF-kappaB (Nuclear Factor-kappa B). Polycyclic Aromatic Hydrocarbons 38-41 nuclear factor kappa B subunit 1 Homo sapiens 316-325 12587778-4 2002 It has been proved that the effect of PAH is caused mostly by the following mechanisms: enzymatic induction by the way of activation of AhR (Aromatic hydrocarbon Receptor); alteration of cellular DNA; development of oxidative stress; increase in the concentration of intercellular calcium and decline of activity of NF-kappaB (Nuclear Factor-kappa B). Polycyclic Aromatic Hydrocarbons 38-41 nuclear factor kappa B subunit 1 Homo sapiens 327-349 11939197-0 2002 Quantification of monohydroxy-PAH metabolites in urine by solid-phase extraction with isotope dilution-GC-MS. For measurement of biomarkers from polycyclic aromatic hydrocarbon (PAH) exposure, an analytical method is described quantifying hydroxylated PAH (OH-PAH) in urine samples. Polycyclic Aromatic Hydrocarbons 145-176 phenylalanine hydroxylase Homo sapiens 30-33 11939197-0 2002 Quantification of monohydroxy-PAH metabolites in urine by solid-phase extraction with isotope dilution-GC-MS. For measurement of biomarkers from polycyclic aromatic hydrocarbon (PAH) exposure, an analytical method is described quantifying hydroxylated PAH (OH-PAH) in urine samples. Polycyclic Aromatic Hydrocarbons 145-176 phenylalanine hydroxylase Homo sapiens 178-181 11939197-0 2002 Quantification of monohydroxy-PAH metabolites in urine by solid-phase extraction with isotope dilution-GC-MS. For measurement of biomarkers from polycyclic aromatic hydrocarbon (PAH) exposure, an analytical method is described quantifying hydroxylated PAH (OH-PAH) in urine samples. Polycyclic Aromatic Hydrocarbons 145-176 phenylalanine hydroxylase Homo sapiens 178-181 12125734-0 2002 Distribution of polycyclic aromatic hydrocarbons in the sediments of the Adriatic Sea. Polycyclic Aromatic Hydrocarbons 16-48 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 82-85 11749126-2 2001 Because PAHs are ubiquitous environmental contaminants, and some are aryl hydrocarbon agonists, CYP1A has been used as a biomarker for PAH exposure. Polycyclic Aromatic Hydrocarbons 8-12 cytochrome P450 1A1 Fundulus heteroclitus 96-101 11749126-2 2001 Because PAHs are ubiquitous environmental contaminants, and some are aryl hydrocarbon agonists, CYP1A has been used as a biomarker for PAH exposure. Polycyclic Aromatic Hydrocarbons 8-11 cytochrome P450 1A1 Fundulus heteroclitus 96-101 11749126-15 2001 Because FL and perhaps other inhibitory PAHs, co-occur in the environment with CYP1A inducers, CYP1A-dependent bioassays may cause an underestimation of PAH exposures. Polycyclic Aromatic Hydrocarbons 40-44 cytochrome P450 1A1 Fundulus heteroclitus 79-84 11749126-15 2001 Because FL and perhaps other inhibitory PAHs, co-occur in the environment with CYP1A inducers, CYP1A-dependent bioassays may cause an underestimation of PAH exposures. Polycyclic Aromatic Hydrocarbons 40-44 cytochrome P450 1A1 Fundulus heteroclitus 95-100 11749126-15 2001 Because FL and perhaps other inhibitory PAHs, co-occur in the environment with CYP1A inducers, CYP1A-dependent bioassays may cause an underestimation of PAH exposures. Polycyclic Aromatic Hydrocarbons 40-43 cytochrome P450 1A1 Fundulus heteroclitus 79-84 11749126-15 2001 Because FL and perhaps other inhibitory PAHs, co-occur in the environment with CYP1A inducers, CYP1A-dependent bioassays may cause an underestimation of PAH exposures. Polycyclic Aromatic Hydrocarbons 40-43 cytochrome P450 1A1 Fundulus heteroclitus 95-100 11675150-10 2001 Taken together, these findings suggest that Chilean people carrying single or combined GSTM1 and CYP1A1 polymorphisms could be more susceptible to lung cancer induced by environmental pollutants such as polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 203-235 glutathione S-transferase mu 1 Homo sapiens 87-92 11675150-10 2001 Taken together, these findings suggest that Chilean people carrying single or combined GSTM1 and CYP1A1 polymorphisms could be more susceptible to lung cancer induced by environmental pollutants such as polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 203-235 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 97-103 11740339-4 2001 This is consistent with a reduced detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAHs) from cigarette smoke that are more important for the development of SCC than for AC. Polycyclic Aromatic Hydrocarbons 65-97 serpin family B member 3 Homo sapiens 173-176 11764156-0 2001 Aryl hydrocarbon receptor-mediated and estrogenic activities of oxygenated polycyclic aromatic hydrocarbons and azaarenes originally identified in extracts of river sediments. Polycyclic Aromatic Hydrocarbons 75-107 aryl hydrocarbon receptor Homo sapiens 0-25 11740339-4 2001 This is consistent with a reduced detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAHs) from cigarette smoke that are more important for the development of SCC than for AC. Polycyclic Aromatic Hydrocarbons 99-103 serpin family B member 3 Homo sapiens 173-176 11695606-7 2001 Addition of C-18 resin as an "alternate sorbent" upon cooling increased recovery of PAHs but not of pesticides, however, it increased the stability of atrazine and propazine at higher temperatures. Polycyclic Aromatic Hydrocarbons 84-88 Bardet-Biedl syndrome 9 Homo sapiens 12-16 11689007-6 2001 It is possible that the abrogation of CYP1A1 induction in the combined Lys(554) + Ile(570) variant may reduce susceptibility of the host to the carcinogenic effects of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 168-200 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 38-44 11600727-13 2001 The variant genotypes of the CYP1A1 gene may result in the enhancement of PAH metabolites. Polycyclic Aromatic Hydrocarbons 74-77 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 29-35 11985329-6 2001 Chemical carcinogens like polycyclic aromatic hydrocarbons are metabolized to reactive species by cytochrome P450 dependent enzymes activated through aryl hydrocarbon (Ah) receptor. Polycyclic Aromatic Hydrocarbons 26-58 aryl hydrocarbon receptor Homo sapiens 150-180 11557128-5 2001 P-gp expression is also up-regulated by numerous chemical carcinogens, such as polycyclic aromatic hydrocarbons and 2-acetylaminofluorene and by some anticancer drugs, such as anthracyclins. Polycyclic Aromatic Hydrocarbons 79-111 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 0-4 11595130-3 2001 Previous studies from this laboratory have shown that, following treatment of pregnant [D2 x B6D2F(1)]F(2) or Balb/c mice with the polycyclic aromatic hydrocarbon, 3-methylcholanthrene (MC), lung tumors from the transplacentally exposed offspring exhibited a high incidence of mutations in the Ki-ras gene. Polycyclic Aromatic Hydrocarbons 131-162 Kirsten rat sarcoma viral oncogene homolog Mus musculus 294-300 11543909-6 2001 Exposure to PAHs-coated onto Fe(2)O(3) particles damaged both the enzymatic (i.e. increases in SOD and GR activities; P<0.01) and the non-enzymatic (i.e. increases in GSSG/GSH; P<0.001, alpha-Toc consumption; P<0.01) antioxidant defenses, thereby allowing lipid peroxidation (i.e. MDA production; P<0.05). Polycyclic Aromatic Hydrocarbons 12-16 superoxide dismutase 1 Homo sapiens 95-98 11694458-7 2001 We demonstrate, for the first time, in airway epithelial cells in vitro that nDEP induce the expression of the CYP1A1, a cytochrome P450 specifically involved in polycyclic aromatic hydrocarbons metabolism, thereby demonstrating the critical role of organic compounds in the DEP-induced proinflammatory response. Polycyclic Aromatic Hydrocarbons 162-194 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 111-117 11694458-9 2001 In conclusion, the DEP-induced inflammatory response in airway epithelial cells mainly involves organic compounds such as PAH, which induce CYP1A1 gene expression. Polycyclic Aromatic Hydrocarbons 122-125 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 140-146 11585742-2 2001 Previous studies have indicated that there is an association between G-to-T transversion hotspots in lung cancers and sites of preferential formation of polycyclic aromatic hydrocarbon adducts along the p53 gene. Polycyclic Aromatic Hydrocarbons 153-184 tumor protein p53 Homo sapiens 203-206 11543909-7 2001 Exposure to PAHs-coated onto Fe(2)O(3) particles induced not only higher lipid peroxidation (i.e. MDA production; P<0.05) but also higher antioxidant alterations (i.e. SOD and GR activities; P<0.05, GSSH/GSH; P<0.01 or P<0.05) than either chemical alone. Polycyclic Aromatic Hydrocarbons 12-16 superoxide dismutase 1 Homo sapiens 171-174 11641039-1 2001 This study was undertaken to investigate the effects of genetic polymorphisms of the cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1), and glutathione S-transferases mu (GSTM1) and theta (GSTT1) on urinary 1-hydroxypyrene and 2-naphthol levels, and to estimate the level of exposure to polycyclic aromatic hydrocarbons (PAHs) in aircraft maintenance workers. Polycyclic Aromatic Hydrocarbons 283-315 glutathione S-transferase mu 1 Homo sapiens 167-172 11559534-0 2001 Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich coal combustion emissions. Polycyclic Aromatic Hydrocarbons 69-72 KRAS proto-oncogene, GTPase Homo sapiens 11-15 11559534-0 2001 Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich coal combustion emissions. Polycyclic Aromatic Hydrocarbons 69-72 tumor protein p53 Homo sapiens 20-24 11641039-1 2001 This study was undertaken to investigate the effects of genetic polymorphisms of the cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1), and glutathione S-transferases mu (GSTM1) and theta (GSTT1) on urinary 1-hydroxypyrene and 2-naphthol levels, and to estimate the level of exposure to polycyclic aromatic hydrocarbons (PAHs) in aircraft maintenance workers. Polycyclic Aromatic Hydrocarbons 317-321 glutathione S-transferase mu 1 Homo sapiens 167-172 11535067-1 2001 Polycyclic aromatic hydrocarbons (PAHs) are metabolized to trans-dihydrodiol proximate carcinogens by human epoxide hydrolase (EH) and CYP1A1. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 11535067-1 2001 Polycyclic aromatic hydrocarbons (PAHs) are metabolized to trans-dihydrodiol proximate carcinogens by human epoxide hydrolase (EH) and CYP1A1. Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 11513123-3 2001 Using fully activated silica gel and cutting off PCB collection after passing 60-65 ml eluting solvent (pentane or hexane) through the column resulted in satisfactory separation of PCBs and PAHs. Polycyclic Aromatic Hydrocarbons 190-194 pyruvate carboxylase Homo sapiens 49-52 11489754-1 2001 Microsomal epoxide hydrolase (mEH) metabolizes polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke and cooked meat. Polycyclic Aromatic Hydrocarbons 47-79 epoxide hydrolase 1 Homo sapiens 0-28 11502724-0 2001 Metabolic activation of polycyclic aromatic hydrocarbons and other procarcinogens by cytochromes P450 1A1 and P450 1B1 allelic variants and other human cytochromes P450 in Salmonella typhimurium NM2009. Polycyclic Aromatic Hydrocarbons 24-56 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 97-118 11506821-6 2001 Earlier in vivo experiments with rodents indicated that indoles and isothiocyanates, two major groups of glucosinolate breakdown products, attenuate the effects of polycyclic aromatic hydrocarbons (PAHs) and nitrosamines via induction of GST and inhibition of cytochrome-P450 isoenzymes, respectively. Polycyclic Aromatic Hydrocarbons 164-196 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 260-275 11448646-9 2001 The results of the present study show that MK amplifies the genotoxic effects of B(a)P in human derived cells and indicate that exposure of humans to MK might increase their susceptibility to the health hazards of B(a)P and other polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 230-262 prohibitin 2 Homo sapiens 81-86 11470762-3 2001 In the present study, we demonstrate that an arginine residue at position 216, which is conserved in some but not all mammalian class Alpha GSTs, plays an important role in catalytic activity of mGSTA1-1 toward (+)-anti-BPDE and carcinogenic diol epoxides of other environmentally relevant polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 290-322 glutathione S-transferase, alpha 1 (Ya) Mus musculus 195-201 11470762-3 2001 In the present study, we demonstrate that an arginine residue at position 216, which is conserved in some but not all mammalian class Alpha GSTs, plays an important role in catalytic activity of mGSTA1-1 toward (+)-anti-BPDE and carcinogenic diol epoxides of other environmentally relevant polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 324-328 glutathione S-transferase, alpha 1 (Ya) Mus musculus 195-201 11470762-8 2001 The results of the present study clearly indicate that an arginine residue at position 216 is critical for catalytic activity of mGSTA1-1 and mGSTA2-2 toward carcinogenic diol epoxide metabolites of various PAHs that are abundant in the environment and suspected human carcinogens. Polycyclic Aromatic Hydrocarbons 207-211 glutathione S-transferase, alpha 1 (Ya) Mus musculus 129-137 11470762-8 2001 The results of the present study clearly indicate that an arginine residue at position 216 is critical for catalytic activity of mGSTA1-1 and mGSTA2-2 toward carcinogenic diol epoxide metabolites of various PAHs that are abundant in the environment and suspected human carcinogens. Polycyclic Aromatic Hydrocarbons 207-211 glutathione S-transferase, alpha 2 (Yc2) Mus musculus 142-148 11470765-9 2001 The association of the CYP2C9 polymorphism to colorectal cancer risk could be related to CYP2C9-mediated metabolic activation of polycyclic aromatic hydrocarbons and heterocyclic aromatic amines. Polycyclic Aromatic Hydrocarbons 129-161 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 23-29 11470765-9 2001 The association of the CYP2C9 polymorphism to colorectal cancer risk could be related to CYP2C9-mediated metabolic activation of polycyclic aromatic hydrocarbons and heterocyclic aromatic amines. Polycyclic Aromatic Hydrocarbons 129-161 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 89-95 11418090-0 2001 Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 and GSTT1. Polycyclic Aromatic Hydrocarbons 38-70 glutathione S-transferase mu 1 Homo sapiens 145-150 11418090-0 2001 Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 and GSTT1. Polycyclic Aromatic Hydrocarbons 38-70 glutathione S-transferase theta 1 Homo sapiens 155-160 11418090-3 2001 OBJECTIVE: This study aimed to assess whether the current exposure to PAH of coke oven workers in a Dutch plant induced biological effects, and to determine if these effects are influenced by tobacco smoking and by genetic polymorphisms for the glutathione S-transferase genes GSTM1 and GSTT1. Polycyclic Aromatic Hydrocarbons 70-73 glutathione S-transferase mu 1 Homo sapiens 277-282 11418090-3 2001 OBJECTIVE: This study aimed to assess whether the current exposure to PAH of coke oven workers in a Dutch plant induced biological effects, and to determine if these effects are influenced by tobacco smoking and by genetic polymorphisms for the glutathione S-transferase genes GSTM1 and GSTT1. Polycyclic Aromatic Hydrocarbons 70-73 glutathione S-transferase theta 1 Homo sapiens 287-292 11497333-17 2001 These data support earlier findings showing modest CYP-mediated AFB1 activation in human airways, but indicate that exposure to polycyclic aromatic hydrocarbons (PAHs), such as 3MC, which induce CYP(s) that specifically activate AFB1 may increase the harmful effects of AFB1 exposures in human airways. Polycyclic Aromatic Hydrocarbons 128-160 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 195-198 11497333-17 2001 These data support earlier findings showing modest CYP-mediated AFB1 activation in human airways, but indicate that exposure to polycyclic aromatic hydrocarbons (PAHs), such as 3MC, which induce CYP(s) that specifically activate AFB1 may increase the harmful effects of AFB1 exposures in human airways. Polycyclic Aromatic Hydrocarbons 162-166 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 195-198 11470762-0 2001 Role of arginine 216 in catalytic activity of murine Alpha class glutathione transferases mGSTAl-1 and mGSTA2-2 toward carcinogenic diol epoxides of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 149-181 glutathione S-transferase, alpha 2 (Yc2) Mus musculus 103-109 11455387-6 2001 Here we show that an exposure of mice to PAHs induces the expression of Bax in oocytes, followed by apoptosis. Polycyclic Aromatic Hydrocarbons 41-45 BCL2-associated X protein Mus musculus 72-75 11455387-9 2001 This difference in the action of PAHs versus dioxin is conveyed by a single base pair flanking each Ahr response element in the Bax promoter. Polycyclic Aromatic Hydrocarbons 33-37 aryl hydrocarbon receptor Homo sapiens 100-103 11455387-9 2001 This difference in the action of PAHs versus dioxin is conveyed by a single base pair flanking each Ahr response element in the Bax promoter. Polycyclic Aromatic Hydrocarbons 33-37 BCL2 associated X, apoptosis regulator Homo sapiens 128-131 11479581-1 2001 Polycyclic aromatic hydrocarbons (PAH), found in cigarette smoke and air pollution, interact with the aryl hydrocarbon receptor (Ahr) to cause reproductive defects. Polycyclic Aromatic Hydrocarbons 0-32 aryl-hydrocarbon receptor Mus musculus 102-127 11479581-1 2001 Polycyclic aromatic hydrocarbons (PAH), found in cigarette smoke and air pollution, interact with the aryl hydrocarbon receptor (Ahr) to cause reproductive defects. Polycyclic Aromatic Hydrocarbons 0-32 aryl-hydrocarbon receptor Mus musculus 129-132 11479581-1 2001 Polycyclic aromatic hydrocarbons (PAH), found in cigarette smoke and air pollution, interact with the aryl hydrocarbon receptor (Ahr) to cause reproductive defects. Polycyclic Aromatic Hydrocarbons 34-37 aryl-hydrocarbon receptor Mus musculus 102-127 11479581-1 2001 Polycyclic aromatic hydrocarbons (PAH), found in cigarette smoke and air pollution, interact with the aryl hydrocarbon receptor (Ahr) to cause reproductive defects. Polycyclic Aromatic Hydrocarbons 34-37 aryl-hydrocarbon receptor Mus musculus 129-132 11479581-2 2001 Mice lacking either Ahr or the pro-apoptotic protein Bax have an increased number of primordial follicles, and these mutant oocytes are resistant to PAH toxicity. Polycyclic Aromatic Hydrocarbons 149-152 aryl-hydrocarbon receptor Mus musculus 20-23 11479581-2 2001 Mice lacking either Ahr or the pro-apoptotic protein Bax have an increased number of primordial follicles, and these mutant oocytes are resistant to PAH toxicity. Polycyclic Aromatic Hydrocarbons 149-152 BCL2-associated X protein Mus musculus 53-56 11479581-3 2001 A new study shows that the Bax promoter contains two core Ahr response elements, which are required for PAH stimulation of Bax promoter activity in oocytes. Polycyclic Aromatic Hydrocarbons 104-107 BCL2-associated X protein Mus musculus 27-30 11479581-3 2001 A new study shows that the Bax promoter contains two core Ahr response elements, which are required for PAH stimulation of Bax promoter activity in oocytes. Polycyclic Aromatic Hydrocarbons 104-107 aryl-hydrocarbon receptor Mus musculus 58-61 11479581-3 2001 A new study shows that the Bax promoter contains two core Ahr response elements, which are required for PAH stimulation of Bax promoter activity in oocytes. Polycyclic Aromatic Hydrocarbons 104-107 BCL2-associated X protein Mus musculus 123-126 11479581-4 2001 Thus, the toxic effects of PAH in oocytes are mediated directly by Ahr induction of the Bax pathway. Polycyclic Aromatic Hydrocarbons 27-30 aryl-hydrocarbon receptor Mus musculus 67-70 11479581-4 2001 Thus, the toxic effects of PAH in oocytes are mediated directly by Ahr induction of the Bax pathway. Polycyclic Aromatic Hydrocarbons 27-30 BCL2-associated X protein Mus musculus 88-91 11505223-7 2001 Thus, p53 accumulates in human skin and lymphocytes as a protective mechanism against polycyclic aromatic hydrocarbon induced DNA damage, and this is more pronounced in GSTM1(-/-) compared to GSTM1(+) individuals. Polycyclic Aromatic Hydrocarbons 86-117 tumor protein p53 Homo sapiens 6-9 11505223-7 2001 Thus, p53 accumulates in human skin and lymphocytes as a protective mechanism against polycyclic aromatic hydrocarbon induced DNA damage, and this is more pronounced in GSTM1(-/-) compared to GSTM1(+) individuals. Polycyclic Aromatic Hydrocarbons 86-117 glutathione S-transferase mu 1 Homo sapiens 169-174 11478240-4 2001 The highest PAH concentration was 11,500 ng/g found in layer 6 of AR-1 (1986), and the lowest was 621 ng/g found in layer 8 of AR-2 (1982). Polycyclic Aromatic Hydrocarbons 12-15 transcription factor 20 Homo sapiens 66-70 11408366-0 2001 Polycyclic aromatic hydrocarbon/metal mixtures: effect on PAH induction of CYP1A1 in human HEPG2 cells. Polycyclic Aromatic Hydrocarbons 0-31 phenylalanine hydroxylase Homo sapiens 58-61 11408366-0 2001 Polycyclic aromatic hydrocarbon/metal mixtures: effect on PAH induction of CYP1A1 in human HEPG2 cells. Polycyclic Aromatic Hydrocarbons 0-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 75-81 11408366-1 2001 Environmental polycyclic aromatic hydrocarbons (PAHs) and metals coexist, and such mixtures could affect the carcinogenicity of PAHs, possibly by modification of PAH induction of the PAH-bioactivating CYP1A. Polycyclic Aromatic Hydrocarbons 14-46 phenylalanine hydroxylase Homo sapiens 48-51 11408366-1 2001 Environmental polycyclic aromatic hydrocarbons (PAHs) and metals coexist, and such mixtures could affect the carcinogenicity of PAHs, possibly by modification of PAH induction of the PAH-bioactivating CYP1A. Polycyclic Aromatic Hydrocarbons 14-46 phenylalanine hydroxylase Homo sapiens 128-131 11408366-1 2001 Environmental polycyclic aromatic hydrocarbons (PAHs) and metals coexist, and such mixtures could affect the carcinogenicity of PAHs, possibly by modification of PAH induction of the PAH-bioactivating CYP1A. Polycyclic Aromatic Hydrocarbons 48-52 phenylalanine hydroxylase Homo sapiens 128-131 11408366-1 2001 Environmental polycyclic aromatic hydrocarbons (PAHs) and metals coexist, and such mixtures could affect the carcinogenicity of PAHs, possibly by modification of PAH induction of the PAH-bioactivating CYP1A. Polycyclic Aromatic Hydrocarbons 128-132 phenylalanine hydroxylase Homo sapiens 48-51 11408366-4 2001 Cells rapidly took up PAHs (BAP, BKF) from medium; by 24 h only 14% remained in the medium, and no detectable PAH bound to well walls. Polycyclic Aromatic Hydrocarbons 22-26 prohibitin 2 Homo sapiens 28-31 11489754-1 2001 Microsomal epoxide hydrolase (mEH) metabolizes polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke and cooked meat. Polycyclic Aromatic Hydrocarbons 47-79 epoxide hydrolase 1, microsomal Mus musculus 30-33 11469723-2 2001 The CYP1A1 gene encodes microsomal cytochrome P4501A1 that catalyzes the metabolism of many xenobiotics, including the oxygenation of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 134-166 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-10 11423332-1 2001 Glutathione S-transferase (GST) has been implicated in the process of biotransformation of polycyclic aromatic hydrocarbons and of other organic pollutants by Chironomidae larvae. Polycyclic Aromatic Hydrocarbons 91-123 glutathione S-transferase kappa 1 Homo sapiens 0-25 11423332-1 2001 Glutathione S-transferase (GST) has been implicated in the process of biotransformation of polycyclic aromatic hydrocarbons and of other organic pollutants by Chironomidae larvae. Polycyclic Aromatic Hydrocarbons 91-123 glutathione S-transferase kappa 1 Homo sapiens 27-30 11469723-2 2001 The CYP1A1 gene encodes microsomal cytochrome P4501A1 that catalyzes the metabolism of many xenobiotics, including the oxygenation of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 168-171 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-10 11469723-3 2001 Induction of CYP1A1 enhances the metabolism of PAHs, and therefore, represents an adaptive response to chemical exposure in mammalian cells. Polycyclic Aromatic Hydrocarbons 47-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 11469723-7 2001 Thus, mechanistic studies of CYP1A1 induction have provided insights into P450 induction, PAH carcinogenesis, dioxin action, AhR function, and receptor-mediated mammalian gene expression. Polycyclic Aromatic Hydrocarbons 90-93 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 29-35 11369471-1 2001 The ability of several 4- and 5-ring polycyclic aromatic hydrocarbons (PAHs), heterocyclic PAHs, and their monohydroxy derivatives to interact with the estrogen receptor (ER) alpha and beta isoforms was examined. Polycyclic Aromatic Hydrocarbons 37-69 estrogen receptor 1 Homo sapiens 152-180 11414039-1 2001 We evaluated a method to determine organic carbon-normalized soil-water partition coefficients (Koc) of 20 PAHs and 12 PCBs by desorption in the presence of a cosolvent (methanol fractions of 0.1-0.9) and at different temperatures (20-80 degrees C). Polycyclic Aromatic Hydrocarbons 107-111 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 96-99 11414039-6 2001 The proposed method is suitable for a routine determination of Koc values of PAHs and PCBs for small soil samples (2-6 g) and low concentrations (down to 0.3 mg kg-1 of sigma 20 PAHs and 1.2 micrograms kg-1 of sigma 12 PCBs). Polycyclic Aromatic Hydrocarbons 77-81 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 63-66 11468695-3 2001 The tumor susceptibility gene P-450 1A1 (CYP1A1) is involved in the activation of polycyclic aromatic hydrocarbons, including benzo[a]pyrene, producing DNA-damaging epoxides that lead to G:C-->T:A point mutations. Polycyclic Aromatic Hydrocarbons 82-114 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 41-47 11369471-1 2001 The ability of several 4- and 5-ring polycyclic aromatic hydrocarbons (PAHs), heterocyclic PAHs, and their monohydroxy derivatives to interact with the estrogen receptor (ER) alpha and beta isoforms was examined. Polycyclic Aromatic Hydrocarbons 71-75 estrogen receptor 1 Homo sapiens 152-180 11369471-1 2001 The ability of several 4- and 5-ring polycyclic aromatic hydrocarbons (PAHs), heterocyclic PAHs, and their monohydroxy derivatives to interact with the estrogen receptor (ER) alpha and beta isoforms was examined. Polycyclic Aromatic Hydrocarbons 91-95 estrogen receptor 1 Homo sapiens 152-180 11358806-4 2001 Oral administration of DBM to female Sprague Dawley rats inhibited the increase in hepatic enzyme activity and mRNA levels of CYP1A1, 1A2, and 1B1 caused by the PAH 7,12-dimethylbenz[a]anthracene (DMBA). Polycyclic Aromatic Hydrocarbons 161-164 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 126-132 11201666-12 2000 The results suggest that endothelial cells may be targets for CYP-dependent activation of such toxicants as polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 108-140 peptidyl-prolyl isomerase G (cyclophilin G) Mus musculus 62-65 11329703-3 2001 We used this material to study the behavior of polycyclic aromatic hydrocarbons (PAHs) that are discharged by the Oder River into the Baltic Sea. Polycyclic Aromatic Hydrocarbons 47-79 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 141-144 11329703-3 2001 We used this material to study the behavior of polycyclic aromatic hydrocarbons (PAHs) that are discharged by the Oder River into the Baltic Sea. Polycyclic Aromatic Hydrocarbons 81-85 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 141-144 11311457-1 2001 The bioactivation of N-nitrosamines and polycyclic aromatic hydrocarbons (PAHs) is mediated primarily by the mixed-function oxidase system, which includes dimethylnitrosamine N-demethylase I, arylhydrocarbon [benzo(a)pyerne] hydroxylase, cytochrome P450, cytochrome b(5), and ethoxycoumarin deethylase. Polycyclic Aromatic Hydrocarbons 40-72 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 238-269 11311457-1 2001 The bioactivation of N-nitrosamines and polycyclic aromatic hydrocarbons (PAHs) is mediated primarily by the mixed-function oxidase system, which includes dimethylnitrosamine N-demethylase I, arylhydrocarbon [benzo(a)pyerne] hydroxylase, cytochrome P450, cytochrome b(5), and ethoxycoumarin deethylase. Polycyclic Aromatic Hydrocarbons 74-78 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 238-269 11507974-8 2001 Thus the prevalence of two polymorphic genes CYP1A1 and GSTM1 responsible for the biotransformation of polycyclic aromatic hydrocarbons was too high in the non-healthy group. Polycyclic Aromatic Hydrocarbons 103-135 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-51 11507974-8 2001 Thus the prevalence of two polymorphic genes CYP1A1 and GSTM1 responsible for the biotransformation of polycyclic aromatic hydrocarbons was too high in the non-healthy group. Polycyclic Aromatic Hydrocarbons 103-135 glutathione S-transferase mu 1 Homo sapiens 56-61 11323156-1 2001 The aryl hydrocarbon receptor (AhR) is a ligand-activated nuclear transcription factor that mediates responses to toxic halogenated aromatic toxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polynuclear aromatic hydrocarbons, combustion products, and numerous phytochemicals such as flavonoids and indole-3-carbinol (I3C). Polycyclic Aromatic Hydrocarbons 200-233 aryl hydrocarbon receptor Homo sapiens 4-29 11323156-1 2001 The aryl hydrocarbon receptor (AhR) is a ligand-activated nuclear transcription factor that mediates responses to toxic halogenated aromatic toxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polynuclear aromatic hydrocarbons, combustion products, and numerous phytochemicals such as flavonoids and indole-3-carbinol (I3C). Polycyclic Aromatic Hydrocarbons 200-233 aryl hydrocarbon receptor Homo sapiens 31-34 11289154-2 2001 Normally DDH is associated with catalysis of polycyclic aromatic hydrocarbons (PAHs) in the liver; in NSCLC cells, DDH expression would implicate an association with disease progression. Polycyclic Aromatic Hydrocarbons 45-77 dihydrodiol dehydrogenase Homo sapiens 9-12 11289154-2 2001 Normally DDH is associated with catalysis of polycyclic aromatic hydrocarbons (PAHs) in the liver; in NSCLC cells, DDH expression would implicate an association with disease progression. Polycyclic Aromatic Hydrocarbons 79-83 dihydrodiol dehydrogenase Homo sapiens 9-12 11223170-8 2001 The tricyclic hydrocarbons phenanthene (the most prevalent polycyclic aromatic hydrocarbon in DEP) and anthracene were both capable of enhancing antigen-specific IgE and IgG1 production. Polycyclic Aromatic Hydrocarbons 59-90 LOC105243590 Mus musculus 170-174 11096091-2 2001 We show that the expression of mdr1 is increased at the transcriptional level upon treatment of the hepatoma cell line Hepa-1c1c7 with the polycyclic aromatic hydrocarbon 3-methylcholanthrene (3-MC). Polycyclic Aromatic Hydrocarbons 139-170 malic enzyme complex, mitochondrial Mus musculus 31-35 11096091-8 2001 Benzo(a)pyrene, a polycyclic aromatic hydrocarbon and AhR ligand, which, like 3-MC, is oxidized by metabolizing enzymes regulated by AhR.Arnt, also activated p53 and induced mdr1 transcription. Polycyclic Aromatic Hydrocarbons 18-49 aryl-hydrocarbon receptor Mus musculus 133-136 11096091-8 2001 Benzo(a)pyrene, a polycyclic aromatic hydrocarbon and AhR ligand, which, like 3-MC, is oxidized by metabolizing enzymes regulated by AhR.Arnt, also activated p53 and induced mdr1 transcription. Polycyclic Aromatic Hydrocarbons 18-49 aryl hydrocarbon receptor nuclear translocator Mus musculus 137-141 11219777-1 2001 Sulfotransferase (SULT) 1A1 is involved in the inactivation of estrogens and bioactivation of heterocyclic amines and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 118-150 sulfotransferase family 1A member 1 Homo sapiens 0-27 11258968-2 2001 Recent studies support depurination of DNA as a mechanism central to the genesis of H-ras mutations in PAH-treated mouse skin. Polycyclic Aromatic Hydrocarbons 103-106 Harvey rat sarcoma virus oncogene Mus musculus 84-89 11156691-3 2001 Human CYP1B1 is involved in activation of chemically diverse human procarcinogens, including polycyclic aromatic hydrocarbons and some aromatic amines, as well as the endogenous hormone 17 beta-estradiol. Polycyclic Aromatic Hydrocarbons 93-125 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 6-12 11160867-5 2001 Here, the role of NF-kappaB, a lymphocyte survival factor, in PAH-induced preB cell apoptosis was assessed. Polycyclic Aromatic Hydrocarbons 62-65 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 18-27 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. Polycyclic Aromatic Hydrocarbons 100-103 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 128-133 11160867-8 2001 Similarly, exposure of BU-11/BMS2 cocultures to 7,12-dimethylbenz[a]anthracene (DMBA), a prototypic PAH, down-regulated nuclear Rel A and c-Rel before overt apoptosis. Polycyclic Aromatic Hydrocarbons 100-103 reticuloendotheliosis oncogene Mus musculus 138-143 11160867-10 2001 These results extend previous observations by demonstrating that 1) NF-kappaB is a survival factor at an earlier stage of B cell development than previously appreciated and 2) NF-kappaB down-regulation is likely to be part of the molecular mechanism resulting in PAH-induced preB cell apoptosis. Polycyclic Aromatic Hydrocarbons 263-266 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 68-77 11160867-10 2001 These results extend previous observations by demonstrating that 1) NF-kappaB is a survival factor at an earlier stage of B cell development than previously appreciated and 2) NF-kappaB down-regulation is likely to be part of the molecular mechanism resulting in PAH-induced preB cell apoptosis. Polycyclic Aromatic Hydrocarbons 263-266 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 176-185 11306097-1 2001 Polycyclic aromatic hydrocarbons (PAHs) are metabolized to trans-dihydrodiol proximate carcinogens by CYP1A1 and epoxide hydrolase (EH). Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 102-108 11306097-1 2001 Polycyclic aromatic hydrocarbons (PAHs) are metabolized to trans-dihydrodiol proximate carcinogens by CYP1A1 and epoxide hydrolase (EH). Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 102-108 11306097-8 2001 The high catalytic efficiency of AKR1A1 for potent proximate carcinogen trans-dihydrodiols and its presence in tissues that contain CYP1A1 and EH suggests that it plays an important role in this alternative pathway of PAH activation (supported by CA39504). Polycyclic Aromatic Hydrocarbons 218-221 aldo-keto reductase family 1 member A1 Homo sapiens 33-39 11306097-8 2001 The high catalytic efficiency of AKR1A1 for potent proximate carcinogen trans-dihydrodiols and its presence in tissues that contain CYP1A1 and EH suggests that it plays an important role in this alternative pathway of PAH activation (supported by CA39504). Polycyclic Aromatic Hydrocarbons 218-221 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 132-138 23886312-7 2001 RGS 6-h responses indicated the presence of PAH in the extracts, which was confirmed by GC/MS analysis. Polycyclic Aromatic Hydrocarbons 44-47 paired like homeodomain 2 Homo sapiens 0-3 23889309-0 2001 Benzo(a)pyrene diolepoxide adducts to albumin in workers exposed to polycyclic aromatic hydrocarbons: association with specific CYP1A1, GSTM1, GSTP1 and EHPX genotypes. Polycyclic Aromatic Hydrocarbons 68-100 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 128-134 23889309-0 2001 Benzo(a)pyrene diolepoxide adducts to albumin in workers exposed to polycyclic aromatic hydrocarbons: association with specific CYP1A1, GSTM1, GSTP1 and EHPX genotypes. Polycyclic Aromatic Hydrocarbons 68-100 epoxide hydrolase 1 Homo sapiens 153-157 11524025-4 2001 PAHs have been shown to induce 3 hepatic cytochrome P450 (CYP) isozymes, primarily CYP1A1, 1A2 and 2E1. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 41-56 11524025-4 2001 PAHs have been shown to induce 3 hepatic cytochrome P450 (CYP) isozymes, primarily CYP1A1, 1A2 and 2E1. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 58-61 11524025-4 2001 PAHs have been shown to induce 3 hepatic cytochrome P450 (CYP) isozymes, primarily CYP1A1, 1A2 and 2E1. Polycyclic Aromatic Hydrocarbons 0-4 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 83-89 11428133-1 2001 The proximity of a busy highway (90,000 vehicles/day) increased the amount of polycyclic aromatic hydrocarbons (PAHs) in soil at the depth of 5-15 cm from 106 ng/g as a grassland background to 3095 ng/g dry soil at the highway verge (a sum of 10 PAH species). Polycyclic Aromatic Hydrocarbons 78-110 phenylalanine hydroxylase Homo sapiens 112-115 11257884-10 2001 PAH carbon was incorporated into cell mass and mineralized after complete biodegradation of the PAHs, with 78-102% recoveries of radiolabel for naphthalene and phenanthrene, respectively. Polycyclic Aromatic Hydrocarbons 96-100 phenylalanine hydroxylase Homo sapiens 0-3 11113705-0 2000 Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1. Polycyclic Aromatic Hydrocarbons 75-106 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 162-187 11238174-4 2001 Previous studies have indicated that there is a good correlation between G-->T transversion hotspots in lung cancers and sites of preferential formation of polycyclic aromatic hydrocarbon (PAH) adducts along the p53 gene. Polycyclic Aromatic Hydrocarbons 159-190 tumor protein p53 Homo sapiens 215-218 11238174-4 2001 Previous studies have indicated that there is a good correlation between G-->T transversion hotspots in lung cancers and sites of preferential formation of polycyclic aromatic hydrocarbon (PAH) adducts along the p53 gene. Polycyclic Aromatic Hydrocarbons 192-195 tumor protein p53 Homo sapiens 215-218 11162773-0 2001 Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocyte cultures. Polycyclic Aromatic Hydrocarbons 20-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-71 11162773-0 2001 Effect of metals on polycyclic aromatic hydrocarbon induction of CYP1A1 and CYP1A2 in human hepatocyte cultures. Polycyclic Aromatic Hydrocarbons 20-51 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 76-82 11162773-7 2001 All four metals (1-5 microM) decreased CYP1A1/1A2 induction by some of the PAHs with dose-, metal-, and PAH-dependency. Polycyclic Aromatic Hydrocarbons 75-79 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 39-45 11162773-7 2001 All four metals (1-5 microM) decreased CYP1A1/1A2 induction by some of the PAHs with dose-, metal-, and PAH-dependency. Polycyclic Aromatic Hydrocarbons 75-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 39-45 11162773-10 2001 Thus the metals in PAH/metal mixtures could diminish PAH carcinogenicity by decreasing induction of their bioactivation by CYP1A1/1A2. Polycyclic Aromatic Hydrocarbons 19-22 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-129 11162773-10 2001 Thus the metals in PAH/metal mixtures could diminish PAH carcinogenicity by decreasing induction of their bioactivation by CYP1A1/1A2. Polycyclic Aromatic Hydrocarbons 53-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-129 11164613-4 2001 In addition, P-glycoprotein and MRP2 mRNA levels were not, or only barely detected, in F258/3MC cells and in their parental counterparts whereas these PAH-resistant and sensitive cells showed closed levels of MRP1 mRNAs and activity. Polycyclic Aromatic Hydrocarbons 151-154 ATP binding cassette subfamily C member 1 Rattus norvegicus 209-213 11062156-1 2000 Glutathione S:-transferase M1 (GSTM1) can detoxify many carcinogens, including polycyclic aromatic hydrocarbons such as those from cigarette smoke. Polycyclic Aromatic Hydrocarbons 79-111 glutathione S-transferase mu 1 Homo sapiens 0-29 11144026-4 2000 Part of the polycyclic aromatic hydrocarbons PAH and alkyl PAH was also degraded. Polycyclic Aromatic Hydrocarbons 12-44 phenylalanine hydroxylase Homo sapiens 45-48 11144026-4 2000 Part of the polycyclic aromatic hydrocarbons PAH and alkyl PAH was also degraded. Polycyclic Aromatic Hydrocarbons 12-44 phenylalanine hydroxylase Homo sapiens 59-62 11062156-1 2000 Glutathione S:-transferase M1 (GSTM1) can detoxify many carcinogens, including polycyclic aromatic hydrocarbons such as those from cigarette smoke. Polycyclic Aromatic Hydrocarbons 79-111 glutathione S-transferase mu 1 Homo sapiens 31-36 11062177-1 2000 The cytochrome P4501A1 (CYP1A1) enzyme is regulated at the transcriptional level and its expression is influenced by genetic factors, polymorphisms in the structural and regulatory genes, and by environmental factors such as exposure to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 237-269 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-22 11062177-1 2000 The cytochrome P4501A1 (CYP1A1) enzyme is regulated at the transcriptional level and its expression is influenced by genetic factors, polymorphisms in the structural and regulatory genes, and by environmental factors such as exposure to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 237-269 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 24-30 11045791-7 2000 However, the GSTM1 null genotype predicted PAH-DNA adduct levels in malignant (beta = 0.407; P = 0.003) and nonmalignant (beta = 0.243; P = 0.05) breast tissue from cases. Polycyclic Aromatic Hydrocarbons 43-46 glutathione S-transferase mu 1 Homo sapiens 13-18 11062177-1 2000 The cytochrome P4501A1 (CYP1A1) enzyme is regulated at the transcriptional level and its expression is influenced by genetic factors, polymorphisms in the structural and regulatory genes, and by environmental factors such as exposure to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 271-275 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 4-22 11062177-1 2000 The cytochrome P4501A1 (CYP1A1) enzyme is regulated at the transcriptional level and its expression is influenced by genetic factors, polymorphisms in the structural and regulatory genes, and by environmental factors such as exposure to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 271-275 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 24-30 11045791-9 2000 When tissue from controls was compared with tumor tissue from cases, there was a significant case-control difference in PAH-DNA adduct levels among women who were GSTM1 null. Polycyclic Aromatic Hydrocarbons 120-123 glutathione S-transferase mu 1 Homo sapiens 163-168 11045797-1 2000 The CYP1A1 and glutathione S-transferase enzymes (e.g., GSTM1 and GSTP1) are involved in the activation and conjugation of polycyclic aromatic hydrocarbons (PAHs), respectively, and are controlled by genes that are polymorphic. Polycyclic Aromatic Hydrocarbons 123-155 glutathione S-transferase Nicotiana tabacum 15-40 11045797-1 2000 The CYP1A1 and glutathione S-transferase enzymes (e.g., GSTM1 and GSTP1) are involved in the activation and conjugation of polycyclic aromatic hydrocarbons (PAHs), respectively, and are controlled by genes that are polymorphic. Polycyclic Aromatic Hydrocarbons 157-161 glutathione S-transferase Nicotiana tabacum 15-40 11198676-3 2000 Cytochrome P450 2E1 (CYP2E1) is a secondary enzyme that can metabolize ethanol, and glutathione S-transferase (GSTM1) is thought to be involved in the detoxification of epoxides and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 182-214 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 0-19 11465078-3 2000 For example, Cyp 1A1 is particularly active towards polycyclic aromatic hydrocarbons (PAHs), activating them into reactive intermediates those covalently bind to DNA, a key event in the initiation of carcinogenesis. Polycyclic Aromatic Hydrocarbons 52-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-20 11465078-3 2000 For example, Cyp 1A1 is particularly active towards polycyclic aromatic hydrocarbons (PAHs), activating them into reactive intermediates those covalently bind to DNA, a key event in the initiation of carcinogenesis. Polycyclic Aromatic Hydrocarbons 86-90 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-20 10953044-2 2000 Much of the biologic activity of one such class of pollutants, polycyclic aromatic hydrocarbons (PAH), is mediated by the aryl hydrocarbon receptor/transcription factor (AhR). Polycyclic Aromatic Hydrocarbons 63-95 aryl hydrocarbon receptor Homo sapiens 122-168 10953044-2 2000 Much of the biologic activity of one such class of pollutants, polycyclic aromatic hydrocarbons (PAH), is mediated by the aryl hydrocarbon receptor/transcription factor (AhR). Polycyclic Aromatic Hydrocarbons 63-95 aryl hydrocarbon receptor Homo sapiens 170-173 10953044-2 2000 Much of the biologic activity of one such class of pollutants, polycyclic aromatic hydrocarbons (PAH), is mediated by the aryl hydrocarbon receptor/transcription factor (AhR). Polycyclic Aromatic Hydrocarbons 97-100 aryl hydrocarbon receptor Homo sapiens 122-168 10953044-2 2000 Much of the biologic activity of one such class of pollutants, polycyclic aromatic hydrocarbons (PAH), is mediated by the aryl hydrocarbon receptor/transcription factor (AhR). Polycyclic Aromatic Hydrocarbons 97-100 aryl hydrocarbon receptor Homo sapiens 170-173 10953044-3 2000 For example, the AhR regulates PAH immunotoxicity that manifests as pre-B cell apoptosis in models of B cell development. Polycyclic Aromatic Hydrocarbons 31-34 aryl hydrocarbon receptor Homo sapiens 17-20 10953044-4 2000 Because bioflavonoids block PAH-induced cell transformation and are structurally similar to AhR ligands, it was postulated that some of them would suppress PAH-induced, AhR-dependent immunotoxicity, possibly through a direct AhR blockade. Polycyclic Aromatic Hydrocarbons 156-159 aryl hydrocarbon receptor Homo sapiens 92-95 10953044-4 2000 Because bioflavonoids block PAH-induced cell transformation and are structurally similar to AhR ligands, it was postulated that some of them would suppress PAH-induced, AhR-dependent immunotoxicity, possibly through a direct AhR blockade. Polycyclic Aromatic Hydrocarbons 156-159 aryl hydrocarbon receptor Homo sapiens 169-172 10953044-4 2000 Because bioflavonoids block PAH-induced cell transformation and are structurally similar to AhR ligands, it was postulated that some of them would suppress PAH-induced, AhR-dependent immunotoxicity, possibly through a direct AhR blockade. Polycyclic Aromatic Hydrocarbons 156-159 aryl hydrocarbon receptor Homo sapiens 169-172 10840162-11 2000 These results are consistent with the notion that exposure to environmental carcinogens that are detoxified by GSTM1, such as polycyclic aromatic hydrocarbons, may contribute to the etiology of esophageal cancer in Linxian. Polycyclic Aromatic Hydrocarbons 126-158 glutathione S-transferase mu 1 Homo sapiens 111-116 10976659-10 2000 The polycyclic aromatic hydrocarbon-inducible cytochrome P450 (CYP) 1A2 participates in the metabolism of caffeine as well as of a number of clinically important drugs. Polycyclic Aromatic Hydrocarbons 4-35 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 46-71 10910056-4 2000 This investigation demonstrates that CYP1B1 null mice are almost completely protected from the acute bone marrow cytotoxic and preleukemic effects of the prototypic PAH 7,12-dimethylbenz[a]anthracene (DMBA). Polycyclic Aromatic Hydrocarbons 165-168 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 37-43 10910056-5 2000 CYP1B1 null mice did not produce the appreciable amounts of bone marrow DMBA dihydrodiol epoxide DNA adducts present in wild-type mice, despite comparable hepatic inductions of the prominent PAH-metabolizing P-450 cytochrome, CYP1A1. Polycyclic Aromatic Hydrocarbons 191-194 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 0-6 10866613-0 2000 New synthetic approaches to polycyclic aromatic hydrocarbons and their carcinogenic oxidized metabolites: derivatives of benzo[s]picene, benzo[rst]pentaphene, and dibenzo[b,def]chrysene. Polycyclic Aromatic Hydrocarbons 28-60 UTP25 small subunit processome component Homo sapiens 173-176 10868696-2 2000 This risk may be modified by variation in metabolism genes, including GSTM1, which encodes an enzyme known to detoxify polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 119-151 glutathione S-transferase mu 1 Homo sapiens 70-75 11087892-2 2000 Mice treated on the dorsal skin with the potent polycyclic aromatic hydrocarbon (PAH) carcinogen dibenzo[a,l]pyrene (DB[a,l]P) form papillomas carrying the H-ras codon 61 (CAA to CTA) mutations. Polycyclic Aromatic Hydrocarbons 48-79 Harvey rat sarcoma virus oncogene Mus musculus 156-161 11087892-2 2000 Mice treated on the dorsal skin with the potent polycyclic aromatic hydrocarbon (PAH) carcinogen dibenzo[a,l]pyrene (DB[a,l]P) form papillomas carrying the H-ras codon 61 (CAA to CTA) mutations. Polycyclic Aromatic Hydrocarbons 81-84 Harvey rat sarcoma virus oncogene Mus musculus 156-161 11037803-4 2000 The activation phase of polycyclic aromatic hydrocarbon (PAH) metabolism is governed by the enzyme CYP1A1, induced by PAH when it enters the body. Polycyclic Aromatic Hydrocarbons 24-55 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-105 11037803-4 2000 The activation phase of polycyclic aromatic hydrocarbon (PAH) metabolism is governed by the enzyme CYP1A1, induced by PAH when it enters the body. Polycyclic Aromatic Hydrocarbons 57-60 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-105 11037803-4 2000 The activation phase of polycyclic aromatic hydrocarbon (PAH) metabolism is governed by the enzyme CYP1A1, induced by PAH when it enters the body. Polycyclic Aromatic Hydrocarbons 118-121 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 99-105 11037803-5 2000 The extent to which PAH induces CYP1A1 activity varies greatly from one subject to another. Polycyclic Aromatic Hydrocarbons 20-23 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-38 11037803-8 2000 The glutathione S-transferases (GSTs) are involved in the detoxification phase of PAH, and the allelic deletion of GSTM1 has been also associated with an increased risk of lung cancer. Polycyclic Aromatic Hydrocarbons 82-85 glutathione S-transferase mu 1 Homo sapiens 32-36 11037803-8 2000 The glutathione S-transferases (GSTs) are involved in the detoxification phase of PAH, and the allelic deletion of GSTM1 has been also associated with an increased risk of lung cancer. Polycyclic Aromatic Hydrocarbons 82-85 glutathione S-transferase mu 1 Homo sapiens 115-120 11097088-2 2000 In animals, PAH induce tumors in part by activating the aryl hydrocarbon receptor (AhR)/transcription factor. Polycyclic Aromatic Hydrocarbons 12-15 aryl hydrocarbon receptor Rattus norvegicus 56-81 11097088-2 2000 In animals, PAH induce tumors in part by activating the aryl hydrocarbon receptor (AhR)/transcription factor. Polycyclic Aromatic Hydrocarbons 12-15 aryl hydrocarbon receptor Rattus norvegicus 83-86 11097088-3 2000 Historically, investigations into AhR-regulated carcinogenesis have focused on AhR-dependent transcriptional regulation of cytochrome P450 (CYP) enzymes which oxidize PAH to mutagenic intermediates. Polycyclic Aromatic Hydrocarbons 167-170 aryl hydrocarbon receptor Rattus norvegicus 34-37 11097088-3 2000 Historically, investigations into AhR-regulated carcinogenesis have focused on AhR-dependent transcriptional regulation of cytochrome P450 (CYP) enzymes which oxidize PAH to mutagenic intermediates. Polycyclic Aromatic Hydrocarbons 167-170 aryl hydrocarbon receptor Rattus norvegicus 79-82 11097088-5 2000 Given the postulated role of the AhR in carcinogenesis, we predicted that: (1) tissue predisposed to PAH tumorigenesis would express the AhR and (2) aberrant AhR and/or AhR-regulated gene expression would accompany malignant transformation. Polycyclic Aromatic Hydrocarbons 101-104 aryl hydrocarbon receptor Rattus norvegicus 33-36 11097088-5 2000 Given the postulated role of the AhR in carcinogenesis, we predicted that: (1) tissue predisposed to PAH tumorigenesis would express the AhR and (2) aberrant AhR and/or AhR-regulated gene expression would accompany malignant transformation. Polycyclic Aromatic Hydrocarbons 101-104 aryl hydrocarbon receptor Rattus norvegicus 137-140 11097088-5 2000 Given the postulated role of the AhR in carcinogenesis, we predicted that: (1) tissue predisposed to PAH tumorigenesis would express the AhR and (2) aberrant AhR and/or AhR-regulated gene expression would accompany malignant transformation. Polycyclic Aromatic Hydrocarbons 101-104 aryl hydrocarbon receptor Rattus norvegicus 137-140 11097088-5 2000 Given the postulated role of the AhR in carcinogenesis, we predicted that: (1) tissue predisposed to PAH tumorigenesis would express the AhR and (2) aberrant AhR and/or AhR-regulated gene expression would accompany malignant transformation. Polycyclic Aromatic Hydrocarbons 101-104 aryl hydrocarbon receptor Rattus norvegicus 137-140 11097088-12 2000 These results: (1) help explain targeting of breast tissue by carcinogenic PAH, (2) imply that AhR and CYP1B1 hyper-expression represent molecular biomarkers for, at least, PAH-induced mammary cell transformation, and (3) suggest mechanisms through which the AhR may contribute to carcinogenesis well after exogenous AhR ligands have been eliminated. Polycyclic Aromatic Hydrocarbons 173-176 aryl hydrocarbon receptor Rattus norvegicus 95-98 11097088-12 2000 These results: (1) help explain targeting of breast tissue by carcinogenic PAH, (2) imply that AhR and CYP1B1 hyper-expression represent molecular biomarkers for, at least, PAH-induced mammary cell transformation, and (3) suggest mechanisms through which the AhR may contribute to carcinogenesis well after exogenous AhR ligands have been eliminated. Polycyclic Aromatic Hydrocarbons 173-176 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 103-109 11097088-12 2000 These results: (1) help explain targeting of breast tissue by carcinogenic PAH, (2) imply that AhR and CYP1B1 hyper-expression represent molecular biomarkers for, at least, PAH-induced mammary cell transformation, and (3) suggest mechanisms through which the AhR may contribute to carcinogenesis well after exogenous AhR ligands have been eliminated. Polycyclic Aromatic Hydrocarbons 173-176 aryl hydrocarbon receptor Rattus norvegicus 259-262 11097088-12 2000 These results: (1) help explain targeting of breast tissue by carcinogenic PAH, (2) imply that AhR and CYP1B1 hyper-expression represent molecular biomarkers for, at least, PAH-induced mammary cell transformation, and (3) suggest mechanisms through which the AhR may contribute to carcinogenesis well after exogenous AhR ligands have been eliminated. Polycyclic Aromatic Hydrocarbons 173-176 aryl hydrocarbon receptor Rattus norvegicus 259-262 10936680-1 2000 We have developed a simple system for rapid detection and measurement of glutathione S-transferase placental form (GSTP1) that detoxify polycyclic aromatic hydrocarbons using the cultured rat normal liver epithelial cell line, (RL34) cells. Polycyclic Aromatic Hydrocarbons 136-168 hematopoietic prostaglandin D synthase Rattus norvegicus 73-98 10936680-1 2000 We have developed a simple system for rapid detection and measurement of glutathione S-transferase placental form (GSTP1) that detoxify polycyclic aromatic hydrocarbons using the cultured rat normal liver epithelial cell line, (RL34) cells. Polycyclic Aromatic Hydrocarbons 136-168 glutathione S-transferase pi 1 Rattus norvegicus 115-120 18968032-1 2000 This article presents considerable improvements in SPE-RTP methodology for the analysis of polycyclic aromatic hydrocarbons in water samples. Polycyclic Aromatic Hydrocarbons 91-123 MORN repeat containing 4 Homo sapiens 55-58 10882891-9 2000 Further, the levels of 4-ABP-DNA adducts were correlated with those of PAH-DNA adducts (r=0.4, P=0.02). Polycyclic Aromatic Hydrocarbons 71-74 auxin-binding protein T92 Nicotiana tabacum 25-28 10837373-0 2000 Polycyclic aromatic hydrocarbon carcinogens increase ubiquitination of p21 protein after the stabilization of p53 and the expression of p21. Polycyclic Aromatic Hydrocarbons 0-31 H3 histone pseudogene 16 Homo sapiens 71-74 10837373-0 2000 Polycyclic aromatic hydrocarbon carcinogens increase ubiquitination of p21 protein after the stabilization of p53 and the expression of p21. Polycyclic Aromatic Hydrocarbons 0-31 tumor protein p53 Homo sapiens 110-113 10837373-0 2000 Polycyclic aromatic hydrocarbon carcinogens increase ubiquitination of p21 protein after the stabilization of p53 and the expression of p21. Polycyclic Aromatic Hydrocarbons 0-31 H3 histone pseudogene 16 Homo sapiens 136-139 10837373-1 2000 Polycyclic aromatic hydrocarbon carcinogens (PAHs) and their metabolites have been found to result in a rapid accumulation of p53 gene product in human and mouse cells. Polycyclic Aromatic Hydrocarbons 0-31 tumor protein p53 Homo sapiens 126-129 10751551-1 2000 Aromatic hydrocarbon receptor-mediated transcriptional up-regulation of cytochrome P450 (CYP) enzymes of the CYP1A subfamily by polycyclic aromatic hydrocarbons (PAHs) such as 3-methylcholanthrene (MC) is accompanied by down-regulation of rat hepatic CYP2C11 expression at the catalytic activity, protein, and mRNA levels. Polycyclic Aromatic Hydrocarbons 128-160 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 72-87 10751551-1 2000 Aromatic hydrocarbon receptor-mediated transcriptional up-regulation of cytochrome P450 (CYP) enzymes of the CYP1A subfamily by polycyclic aromatic hydrocarbons (PAHs) such as 3-methylcholanthrene (MC) is accompanied by down-regulation of rat hepatic CYP2C11 expression at the catalytic activity, protein, and mRNA levels. Polycyclic Aromatic Hydrocarbons 128-160 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 89-92 10751551-1 2000 Aromatic hydrocarbon receptor-mediated transcriptional up-regulation of cytochrome P450 (CYP) enzymes of the CYP1A subfamily by polycyclic aromatic hydrocarbons (PAHs) such as 3-methylcholanthrene (MC) is accompanied by down-regulation of rat hepatic CYP2C11 expression at the catalytic activity, protein, and mRNA levels. Polycyclic Aromatic Hydrocarbons 128-160 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 251-258 10751551-1 2000 Aromatic hydrocarbon receptor-mediated transcriptional up-regulation of cytochrome P450 (CYP) enzymes of the CYP1A subfamily by polycyclic aromatic hydrocarbons (PAHs) such as 3-methylcholanthrene (MC) is accompanied by down-regulation of rat hepatic CYP2C11 expression at the catalytic activity, protein, and mRNA levels. Polycyclic Aromatic Hydrocarbons 162-166 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 72-87 10751551-1 2000 Aromatic hydrocarbon receptor-mediated transcriptional up-regulation of cytochrome P450 (CYP) enzymes of the CYP1A subfamily by polycyclic aromatic hydrocarbons (PAHs) such as 3-methylcholanthrene (MC) is accompanied by down-regulation of rat hepatic CYP2C11 expression at the catalytic activity, protein, and mRNA levels. Polycyclic Aromatic Hydrocarbons 162-166 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 89-92 10751551-1 2000 Aromatic hydrocarbon receptor-mediated transcriptional up-regulation of cytochrome P450 (CYP) enzymes of the CYP1A subfamily by polycyclic aromatic hydrocarbons (PAHs) such as 3-methylcholanthrene (MC) is accompanied by down-regulation of rat hepatic CYP2C11 expression at the catalytic activity, protein, and mRNA levels. Polycyclic Aromatic Hydrocarbons 162-166 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 251-258 11198676-3 2000 Cytochrome P450 2E1 (CYP2E1) is a secondary enzyme that can metabolize ethanol, and glutathione S-transferase (GSTM1) is thought to be involved in the detoxification of epoxides and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 182-214 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 21-27 11198676-3 2000 Cytochrome P450 2E1 (CYP2E1) is a secondary enzyme that can metabolize ethanol, and glutathione S-transferase (GSTM1) is thought to be involved in the detoxification of epoxides and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 182-214 glutathione S-transferase kappa 1 Homo sapiens 84-109 11198676-3 2000 Cytochrome P450 2E1 (CYP2E1) is a secondary enzyme that can metabolize ethanol, and glutathione S-transferase (GSTM1) is thought to be involved in the detoxification of epoxides and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 182-214 glutathione S-transferase mu 1 Homo sapiens 111-116 10771140-0 2000 Environmental polycyclic aromatic hydrocarbons affect androgen receptor activation in vitro. Polycyclic Aromatic Hydrocarbons 14-46 androgen receptor Homo sapiens 54-71 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 152-184 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-87 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 152-184 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 89-92 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 152-184 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 109-115 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 152-184 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 117-123 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 152-184 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 128-133 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 186-189 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-87 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 186-189 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 89-92 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 186-189 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 109-115 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 186-189 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 117-123 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 186-189 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 128-133 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 194-197 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-87 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 194-197 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 89-92 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 194-197 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 109-115 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 194-197 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 117-123 10797280-2 2000 This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize polycyclic aromatic hydrocarbons (PAH) on PAH-DNA adduct formation in the bronchoalveolar macrophages (BAM) of 31 smokers and 16 non-smokers. Polycyclic Aromatic Hydrocarbons 194-197 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 128-133 10814675-5 2000 METHODS: Here we have mapped the distribution of adducts induced by diol epoxides of additional PAHs: chrysene (CDE), 5-methylchrysene (5-MCDE), 6-methylchrysene (6-MCDE), benzo[c]phenanthrene (B[c]PDE), and benzo[g]chrysene (B[g]CDE) within exons 5, 7, and 8 of the p53 gene in human bronchial epithelial cells. Polycyclic Aromatic Hydrocarbons 96-100 tumor protein p53 Homo sapiens 267-270 10779392-1 2000 The aryl hydrocarbon receptor (AHR) is known to mediate the toxic and carcinogenic effects of polycyclic aromatic hydrocarbons and dioxins. Polycyclic Aromatic Hydrocarbons 94-126 aryl-hydrocarbon receptor Mus musculus 4-29 10779392-1 2000 The aryl hydrocarbon receptor (AHR) is known to mediate the toxic and carcinogenic effects of polycyclic aromatic hydrocarbons and dioxins. Polycyclic Aromatic Hydrocarbons 94-126 aryl-hydrocarbon receptor Mus musculus 31-34 10845796-3 2000 The extraction efficiency, which can be easily monitored, has been investigated in a factorial design and validated for polycyclic aromatic hydrocarbons in a reference sediment sample (EC-1). Polycyclic Aromatic Hydrocarbons 120-152 Susceptibility to lysis by alloreactive natural killer cells Homo sapiens 185-189 10771140-1 2000 Nine structurally different polycyclic aromatic hydrocarbons (PAHs) were tested for their ability to either agonize or antagonize the human androgen receptor (hAR) in a sensitive reporter gene assay based on CHO cells transiently cotransfected with a hAR vector and an MMTV-LUC vector. Polycyclic Aromatic Hydrocarbons 62-66 androgen receptor Homo sapiens 140-157 10771140-1 2000 Nine structurally different polycyclic aromatic hydrocarbons (PAHs) were tested for their ability to either agonize or antagonize the human androgen receptor (hAR) in a sensitive reporter gene assay based on CHO cells transiently cotransfected with a hAR vector and an MMTV-LUC vector. Polycyclic Aromatic Hydrocarbons 62-66 lymphatic vessel endothelial hyaluronan receptor 1 Homo sapiens 159-162 10753202-0 2000 CYP1A1 and GSTM1 polymorphisms affect urinary 1-hydroxypyrene levels after PAH exposure. Polycyclic Aromatic Hydrocarbons 75-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 10753202-0 2000 CYP1A1 and GSTM1 polymorphisms affect urinary 1-hydroxypyrene levels after PAH exposure. Polycyclic Aromatic Hydrocarbons 75-78 glutathione S-transferase mu 1 Homo sapiens 11-16 10928648-2 2000 In the literature there has been evidence presented for the use of p21ras (ras) as a tumor marker for human carcinogenic substances such as asbestos, polycyclic aromatic hydrocarbons, and vinyl chloride in the workplace. Polycyclic Aromatic Hydrocarbons 150-182 HRas proto-oncogene, GTPase Homo sapiens 67-73 10728779-1 2000 The aromatic hydrocarbon receptor (AHR) and AHR nuclear translocator protein (ARNT) mediate the toxic effects of a wide variety of halogenated and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 147-179 aryl hydrocarbon receptor Rattus norvegicus 4-33 10698668-2 2000 Hepatic CYP2C11 expression is down-regulated by polycyclic aromatic hydrocarbons such as 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons 48-80 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 8-15 10706104-1 2000 Procarcinogenic polycyclic aromatic hydrocarbons (PAHs) induce their own metabolism and activation by binding to the cytosolic aryl hydrocarbon receptor (AhR), which then translocates to the nucleus and activates CYP1A1 gene transcription via xenobiotic response elements (XREs). Polycyclic Aromatic Hydrocarbons 16-48 aryl hydrocarbon receptor Homo sapiens 127-152 10706104-1 2000 Procarcinogenic polycyclic aromatic hydrocarbons (PAHs) induce their own metabolism and activation by binding to the cytosolic aryl hydrocarbon receptor (AhR), which then translocates to the nucleus and activates CYP1A1 gene transcription via xenobiotic response elements (XREs). Polycyclic Aromatic Hydrocarbons 16-48 aryl hydrocarbon receptor Homo sapiens 154-157 10706104-1 2000 Procarcinogenic polycyclic aromatic hydrocarbons (PAHs) induce their own metabolism and activation by binding to the cytosolic aryl hydrocarbon receptor (AhR), which then translocates to the nucleus and activates CYP1A1 gene transcription via xenobiotic response elements (XREs). Polycyclic Aromatic Hydrocarbons 16-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 213-219 10706104-1 2000 Procarcinogenic polycyclic aromatic hydrocarbons (PAHs) induce their own metabolism and activation by binding to the cytosolic aryl hydrocarbon receptor (AhR), which then translocates to the nucleus and activates CYP1A1 gene transcription via xenobiotic response elements (XREs). Polycyclic Aromatic Hydrocarbons 50-54 aryl hydrocarbon receptor Homo sapiens 127-152 10706104-1 2000 Procarcinogenic polycyclic aromatic hydrocarbons (PAHs) induce their own metabolism and activation by binding to the cytosolic aryl hydrocarbon receptor (AhR), which then translocates to the nucleus and activates CYP1A1 gene transcription via xenobiotic response elements (XREs). Polycyclic Aromatic Hydrocarbons 50-54 aryl hydrocarbon receptor Homo sapiens 154-157 10706104-1 2000 Procarcinogenic polycyclic aromatic hydrocarbons (PAHs) induce their own metabolism and activation by binding to the cytosolic aryl hydrocarbon receptor (AhR), which then translocates to the nucleus and activates CYP1A1 gene transcription via xenobiotic response elements (XREs). Polycyclic Aromatic Hydrocarbons 50-54 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 213-219 10728779-1 2000 The aromatic hydrocarbon receptor (AHR) and AHR nuclear translocator protein (ARNT) mediate the toxic effects of a wide variety of halogenated and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 147-179 aryl hydrocarbon receptor Rattus norvegicus 35-38 10728779-1 2000 The aromatic hydrocarbon receptor (AHR) and AHR nuclear translocator protein (ARNT) mediate the toxic effects of a wide variety of halogenated and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 147-179 aryl hydrocarbon receptor nuclear translocator Rattus norvegicus 44-76 10728779-1 2000 The aromatic hydrocarbon receptor (AHR) and AHR nuclear translocator protein (ARNT) mediate the toxic effects of a wide variety of halogenated and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 147-179 aryl hydrocarbon receptor nuclear translocator Rattus norvegicus 78-82 10651994-8 2000 Ultraviolet-B induction of both cytochrome P450 1A1 and cytochrome P450 1B1 in human skin will probably result in enhanced bioactivation of polycyclic aromatic hydrocarbons and other environmental pollutants to which humans are exposed, which in turn could make the human skin more susceptible to ultraviolet-B-induced skin cancers or allergic and irritant contact dermatitis. Polycyclic Aromatic Hydrocarbons 140-172 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-51 10698483-0 2000 Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP1A1 polymorphisms. Polycyclic Aromatic Hydrocarbons 20-51 glutathione S-transferase pi 1 Homo sapiens 116-144 10698483-0 2000 Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP1A1 polymorphisms. Polycyclic Aromatic Hydrocarbons 20-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 149-155 10677833-5 2000 The reproducibility of the technique is less than 13% (RDS) for the first 6 considered PAHs and 28% (RDS) for benzo(a)anthracene with a fiber containing a 100-micron poly dimethylsiloxane coating. Polycyclic Aromatic Hydrocarbons 87-91 peripherin 2 Homo sapiens 55-58 10651994-8 2000 Ultraviolet-B induction of both cytochrome P450 1A1 and cytochrome P450 1B1 in human skin will probably result in enhanced bioactivation of polycyclic aromatic hydrocarbons and other environmental pollutants to which humans are exposed, which in turn could make the human skin more susceptible to ultraviolet-B-induced skin cancers or allergic and irritant contact dermatitis. Polycyclic Aromatic Hydrocarbons 140-172 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 56-75 10636867-2 2000 Cells that acquire PAH-induced DNA damage undergo growth arrest in a p53-independent manner (Vaziri, C., and Faller, D. V. (1997) J. Biol. Polycyclic Aromatic Hydrocarbons 19-22 tumor protein p53 Homo sapiens 69-72 10636867-7 2000 However, PAH-induced growth arrest was associated with post-transcriptional decreases in cyclin A expression. Polycyclic Aromatic Hydrocarbons 9-12 cyclin A2 Homo sapiens 89-97 10636867-8 2000 Mitogen-induced expression of cyclin B, an event that is temporally distal to cyclin A expression, was also inhibited in PAH-treated cells. Polycyclic Aromatic Hydrocarbons 121-124 cyclin A2 Homo sapiens 78-86 10636867-10 2000 Resumption of DNA synthesis in PAH-treated cells occurred concomitant with elevated expression of cyclins A and B. Polycyclic Aromatic Hydrocarbons 31-34 cyclin A2 Homo sapiens 98-113 10636867-11 2000 PAH-induced cell cycle arrest was overcome by ectopically expressed cyclin A (encoded by a recombinant adenovirus in transiently infected cells). Polycyclic Aromatic Hydrocarbons 0-3 cyclin A2 Homo sapiens 68-76 10506754-1 1999 The objective of this study was to investigate whether polycyclic aromatic hydrocarbons (PAHs) contribute to the etiology of sporadic breast cancer by altering the expression of BRCA-1. Polycyclic Aromatic Hydrocarbons 55-87 BRCA1 DNA repair associated Homo sapiens 178-184 10631103-1 2000 CYP1A1 is implicated in the bioactivation of procarcinogens such as polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 68-100 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 11996099-1 2000 In contrast to the well-known Ah receptor-mediated regulation of the CYP1A1 gene by polycyclic aromatic hydrocarbons, the molecular mechanism by which phenobarbital (PB) and PB-like inducers affect transcription of CYP genes remains unknown; no receptor for these chemicals has been found to date. Polycyclic Aromatic Hydrocarbons 84-116 aryl hydrocarbon receptor Homo sapiens 30-41 11996099-1 2000 In contrast to the well-known Ah receptor-mediated regulation of the CYP1A1 gene by polycyclic aromatic hydrocarbons, the molecular mechanism by which phenobarbital (PB) and PB-like inducers affect transcription of CYP genes remains unknown; no receptor for these chemicals has been found to date. Polycyclic Aromatic Hydrocarbons 84-116 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 69-75 23886023-1 2000 1-Hydroxypyrene (1-OHP) urinary excretion has been studied in subjects exposed to polycyclic aromatic hydrocarbons (PAH) from different sources (urban air pollution, cigarette smoking, food contamination or occupational exposure). Polycyclic Aromatic Hydrocarbons 82-114 phenylalanine hydroxylase Homo sapiens 116-119 10611137-13 2000 It is well documented that DEX potentiates the inductory effect of polycyclic aromatic hydrocarbon on UGT1A6 (). Polycyclic Aromatic Hydrocarbons 67-98 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 102-108 10614669-1 2000 The aryl hydrocarbon receptor (AhR), so-designated based on the ability of the protein to bind with and be activated by polycyclic aromatic hydrocarbons (PAH) and related halogenated hydrocarbons, is part of an emerging family of ligand-activated transcriptional regulators that are distinct from the steroid-thyroid hormone receptor superfamily. Polycyclic Aromatic Hydrocarbons 120-152 aryl-hydrocarbon receptor Mus musculus 4-29 10614669-1 2000 The aryl hydrocarbon receptor (AhR), so-designated based on the ability of the protein to bind with and be activated by polycyclic aromatic hydrocarbons (PAH) and related halogenated hydrocarbons, is part of an emerging family of ligand-activated transcriptional regulators that are distinct from the steroid-thyroid hormone receptor superfamily. Polycyclic Aromatic Hydrocarbons 120-152 aryl-hydrocarbon receptor Mus musculus 31-34 10614669-1 2000 The aryl hydrocarbon receptor (AhR), so-designated based on the ability of the protein to bind with and be activated by polycyclic aromatic hydrocarbons (PAH) and related halogenated hydrocarbons, is part of an emerging family of ligand-activated transcriptional regulators that are distinct from the steroid-thyroid hormone receptor superfamily. Polycyclic Aromatic Hydrocarbons 154-157 aryl-hydrocarbon receptor Mus musculus 4-29 10614669-1 2000 The aryl hydrocarbon receptor (AhR), so-designated based on the ability of the protein to bind with and be activated by polycyclic aromatic hydrocarbons (PAH) and related halogenated hydrocarbons, is part of an emerging family of ligand-activated transcriptional regulators that are distinct from the steroid-thyroid hormone receptor superfamily. Polycyclic Aromatic Hydrocarbons 154-157 aryl-hydrocarbon receptor Mus musculus 31-34 10614669-5 2000 In the ovary, PAH exposure is known to cause destruction of oocytes within immature follicles, implying that one function of the AhR is to mediate cell death signaling in the female germ line. Polycyclic Aromatic Hydrocarbons 14-17 aryl-hydrocarbon receptor Mus musculus 129-132 10867371-7 2000 Results indicate that RGS testing at 6 and 16 h is a promising tool to differentiate between PAHs and chlorinated hydrocarbons often co-occurring in environmental samples. Polycyclic Aromatic Hydrocarbons 93-97 paired like homeodomain 2 Homo sapiens 22-25 26368636-6 2000 Organic extracts of DEP increased NF-kappaB DNA binding as did native DEP, suggesting the role of the polycyclic aromatic hydrocarbons (PAH) in this NF-kappaB increased DNA binding. Polycyclic Aromatic Hydrocarbons 102-134 nuclear factor kappa B subunit 1 Homo sapiens 34-43 26368636-6 2000 Organic extracts of DEP increased NF-kappaB DNA binding as did native DEP, suggesting the role of the polycyclic aromatic hydrocarbons (PAH) in this NF-kappaB increased DNA binding. Polycyclic Aromatic Hydrocarbons 102-134 nuclear factor kappa B subunit 1 Homo sapiens 149-158 26368636-6 2000 Organic extracts of DEP increased NF-kappaB DNA binding as did native DEP, suggesting the role of the polycyclic aromatic hydrocarbons (PAH) in this NF-kappaB increased DNA binding. Polycyclic Aromatic Hydrocarbons 136-139 nuclear factor kappa B subunit 1 Homo sapiens 34-43 26368636-6 2000 Organic extracts of DEP increased NF-kappaB DNA binding as did native DEP, suggesting the role of the polycyclic aromatic hydrocarbons (PAH) in this NF-kappaB increased DNA binding. Polycyclic Aromatic Hydrocarbons 136-139 nuclear factor kappa B subunit 1 Homo sapiens 149-158 10859543-3 2000 The glutathione-S-transferase Mu1 enzyme (GSTM1) detoxifies arylepoxides which are formed after exposure to certain polycyclic aromatic hydrocarbons and possibly aromatic amines. Polycyclic Aromatic Hydrocarbons 116-148 glutathione S-transferase mu 1 Homo sapiens 4-40 10859543-3 2000 The glutathione-S-transferase Mu1 enzyme (GSTM1) detoxifies arylepoxides which are formed after exposure to certain polycyclic aromatic hydrocarbons and possibly aromatic amines. Polycyclic Aromatic Hydrocarbons 116-148 glutathione S-transferase mu 1 Homo sapiens 42-47 10635993-1 1999 We studied mutations in exon 3 of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in 113 6-thioguanine-resistant T-cell clones derived from coke-oven workers and control subjects in order to analyse possible changes in the mutational spectrum associated with the exposure to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 291-323 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 86-90 10635993-1 1999 We studied mutations in exon 3 of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in 113 6-thioguanine-resistant T-cell clones derived from coke-oven workers and control subjects in order to analyse possible changes in the mutational spectrum associated with the exposure to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 325-329 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 86-90 10575002-3 1999 DHEA inhibited the increase in CYP1A1 enzyme activity that occurs when MCF-7 cells are exposed to the PAH dimethylbenzanthracene (DMBA) or 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD). Polycyclic Aromatic Hydrocarbons 102-105 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 31-37 10575002-8 1999 These data demonstrate that DHEA inhibits PAH-induced CYP1A1 mRNA expression and enzyme activity in vitro by a post-transcriptional mechanism. Polycyclic Aromatic Hydrocarbons 42-45 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 54-60 10558919-5 1999 Three poorly metabolized AhR ligands, 2,3,7,8-tetrachlorodibenzo-p-dioxin, 3,3",4,4",5-pentachlorobiphenyl, and 3,3",4,4"-tetrachlorobiphenyl failed to induce pre-B cell apoptosis in bone marrow cultures, indicating that AhR activation alone is not sufficient to induce apoptosis and suggesting a role for PAH metabolism in induction of an apoptosis signal. Polycyclic Aromatic Hydrocarbons 306-309 aryl hydrocarbon receptor Homo sapiens 25-28 10558919-9 1999 These data confirm a role for the AhR in PAH-induced pre-B cell apoptosis, indicate a role for DMBA metabolism, and suggest a feedback loop in which at least one product of DMBA metabolism augments AhR signaling, leading to induction of an apoptosis stimulus. Polycyclic Aromatic Hydrocarbons 41-44 aryl hydrocarbon receptor Homo sapiens 34-37 10558919-9 1999 These data confirm a role for the AhR in PAH-induced pre-B cell apoptosis, indicate a role for DMBA metabolism, and suggest a feedback loop in which at least one product of DMBA metabolism augments AhR signaling, leading to induction of an apoptosis stimulus. Polycyclic Aromatic Hydrocarbons 41-44 aryl hydrocarbon receptor Homo sapiens 198-201 10525285-2 1999 When probed with antibodies raised against rat CYP1A1, a 54-kDa protein was detected after administration of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 109-141 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 47-53 10506754-1 1999 The objective of this study was to investigate whether polycyclic aromatic hydrocarbons (PAHs) contribute to the etiology of sporadic breast cancer by altering the expression of BRCA-1. Polycyclic Aromatic Hydrocarbons 89-93 BRCA1 DNA repair associated Homo sapiens 178-184 10506754-2 1999 Acute exposure to the PAH benzo[a]pyrene (B[a]P) inhibited in a time- and dose-dependent fashion cell proliferation and levels of BRCA-1 mRNA and protein in estrogen receptor (ER)-positive breast MCF-7 and ovarian BG-1 cancer cells. Polycyclic Aromatic Hydrocarbons 22-25 BRCA1 DNA repair associated Homo sapiens 130-136 10506754-2 1999 Acute exposure to the PAH benzo[a]pyrene (B[a]P) inhibited in a time- and dose-dependent fashion cell proliferation and levels of BRCA-1 mRNA and protein in estrogen receptor (ER)-positive breast MCF-7 and ovarian BG-1 cancer cells. Polycyclic Aromatic Hydrocarbons 22-25 estrogen receptor 1 Homo sapiens 157-174 10506754-2 1999 Acute exposure to the PAH benzo[a]pyrene (B[a]P) inhibited in a time- and dose-dependent fashion cell proliferation and levels of BRCA-1 mRNA and protein in estrogen receptor (ER)-positive breast MCF-7 and ovarian BG-1 cancer cells. Polycyclic Aromatic Hydrocarbons 22-25 estrogen receptor 1 Homo sapiens 176-178 10493514-2 1999 P450 1A1 and 1B1 are the major P450s involved in metabolic activation of polycyclic aromatic hydrocarbons in human cells. Polycyclic Aromatic Hydrocarbons 73-105 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-16 10511262-2 1999 PAH metabolites in human urine can be used as biomarkers of internal dose to assess recent exposure to PAHs. Polycyclic Aromatic Hydrocarbons 103-107 phenylalanine hydroxylase Homo sapiens 0-3 10511265-10 1999 It is important to note the variability of individual PAH metabolite excretion due to different GSTM1 and GSTT1 genotypes. Polycyclic Aromatic Hydrocarbons 54-57 glutathione S-transferase mu 1 Homo sapiens 96-101 10511265-10 1999 It is important to note the variability of individual PAH metabolite excretion due to different GSTM1 and GSTT1 genotypes. Polycyclic Aromatic Hydrocarbons 54-57 glutathione S-transferase theta 1 Homo sapiens 106-111 10381914-1 1999 BACKGROUND & AIMS: Carcinogenic heterocyclic amines and polycyclic aromatic hydrocarbons present in chargrilled meat are substrates for inducible CYP1A and CYP3A enzymes and for P-glycoprotein. Polycyclic Aromatic Hydrocarbons 60-92 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 160-165 10409767-2 1999 Upon binding of polycyclic aromatic hydrocarbons typified by dioxin, the dioxin receptor translocates from the cytoplasm to the nucleus to allow interaction with Arnt. Polycyclic Aromatic Hydrocarbons 16-48 aryl hydrocarbon receptor nuclear translocator Homo sapiens 162-166 10404042-2 1999 In long-term bone marrow B-cell lymphopoiesis models, PAH induce apoptosis in immature (preB) lymphocytes. Polycyclic Aromatic Hydrocarbons 54-57 prolactin regulatory element binding Mus musculus 88-92 10404042-3 1999 Since the biologic function of PAH is often mediated by the aryl hydrocarbon receptor/transcription factor (AhR), the role of the AhR or AhR-regulated genes was assessed in preB cell apoptosis. Polycyclic Aromatic Hydrocarbons 31-34 prolactin regulatory element binding Mus musculus 173-177 10404042-7 1999 Collectively, the data indicated that AhR-regulated activities in the hematopoietic microenvironment influence the susceptibility of immature lymphocytes to low-dose PAH exposure. Polycyclic Aromatic Hydrocarbons 166-169 aryl-hydrocarbon receptor Mus musculus 38-41 10454223-3 1999 While the CD4+ cell percentage and the CD4+/CD8+ ratio were significantly higher in the PAH-exposed group, the percentages of CD8+ and CD19+ cells were unchanged. Polycyclic Aromatic Hydrocarbons 88-91 CD4 molecule Homo sapiens 10-13 10454223-3 1999 While the CD4+ cell percentage and the CD4+/CD8+ ratio were significantly higher in the PAH-exposed group, the percentages of CD8+ and CD19+ cells were unchanged. Polycyclic Aromatic Hydrocarbons 88-91 CD4 molecule Homo sapiens 39-42 10454223-3 1999 While the CD4+ cell percentage and the CD4+/CD8+ ratio were significantly higher in the PAH-exposed group, the percentages of CD8+ and CD19+ cells were unchanged. Polycyclic Aromatic Hydrocarbons 88-91 CD8a molecule Homo sapiens 44-47 10359656-12 1999 Known ligands of the AhR are, for the most part, man-made compounds such as halogenated and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 92-124 aryl hydrocarbon receptor Homo sapiens 21-24 10357801-2 1999 In this study, the tumorigenicity of three single cyclopenta-fused polycyclic aromatic hydrocarbons, aceanthrylene, dihydroaceanthrylene and acephenanthrylene, was examined in preweanling CD-1 and BLU:Ha mouse bioassays at total doses of 175, 437.5 and 875 micrograms/mouse. Polycyclic Aromatic Hydrocarbons 67-99 CD1 antigen complex Mus musculus 188-200 10357803-1 1999 Dibenzo[a,l]pyrene (DBP), an environmentally significant polycyclic aromatic hydrocarbon (PAH), is one of the most potent carcinogens with greater carcinogenicity in rodent mammary glands and skin than 7,12-dimethylbenz[a]anthracene or benzo[a]pyrene, respectively. Polycyclic Aromatic Hydrocarbons 57-88 D-box binding PAR bZIP transcription factor Rattus norvegicus 20-23 10357803-1 1999 Dibenzo[a,l]pyrene (DBP), an environmentally significant polycyclic aromatic hydrocarbon (PAH), is one of the most potent carcinogens with greater carcinogenicity in rodent mammary glands and skin than 7,12-dimethylbenz[a]anthracene or benzo[a]pyrene, respectively. Polycyclic Aromatic Hydrocarbons 90-93 D-box binding PAR bZIP transcription factor Rattus norvegicus 20-23 10427467-5 1999 Polycyclic aromatic hydrocarbons in tobacco smoke are believed to be responsible for the induction of cytochrome P450 (CYP) 1A1, CYP1A2 and possibly CYP2E1, CYP1A1 is primarily an extrahepatic enzyme found in lung and placenta. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 157-163 10443949-5 1999 Other links between meat, cooking methods, metabolic genotypes and risk for cancer might include enhanced activation of polycyclic aromatic hydrocarbons and N-nitroso compounds by variant genotypes of CYP1A1 and CYP2E1, respectively, and modulation by meat of the protective effect of the E4 allele of apolipoprotein E on risk for cancer of the proximal colon. Polycyclic Aromatic Hydrocarbons 120-152 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 201-207 10408872-2 1999 Cytochrome P450 1A1 (CYP1A1) is involved in the biotransformation of tobacco-derived polycyclic aromatic hydrocarbons (PAHs) into carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 85-117 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 10408872-2 1999 Cytochrome P450 1A1 (CYP1A1) is involved in the biotransformation of tobacco-derived polycyclic aromatic hydrocarbons (PAHs) into carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 119-123 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 10408872-7 1999 The smoking-related HCC risk was most pronounced among those who had a susceptible allele of the CYP1A1 and a deficient genotype of glutathione S-transferase M1, which detoxifies PAH electrophilic metabolites produced by CYP1A1. Polycyclic Aromatic Hydrocarbons 179-182 glutathione S-transferase mu 2 Homo sapiens 132-160 10355543-3 1999 Without CPF-oxon, all four PAHs themselves inhibited AChE activity with IC50 values in the range 8.2-17 microM. Polycyclic Aromatic Hydrocarbons 27-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-57 10355543-5 1999 When AChE was incubated with CPF-oxon together with the PAHs, the inhibitory effect on AChE was additive. Polycyclic Aromatic Hydrocarbons 56-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 10355543-5 1999 When AChE was incubated with CPF-oxon together with the PAHs, the inhibitory effect on AChE was additive. Polycyclic Aromatic Hydrocarbons 56-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-91 10355543-6 1999 This was exemplified by large (60-80%) and significant (P<0.01) inhibition in AChE activity by the PAHs when combined with nanomolar concentrations of CPF-oxon. Polycyclic Aromatic Hydrocarbons 102-106 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-85 10381914-1 1999 BACKGROUND & AIMS: Carcinogenic heterocyclic amines and polycyclic aromatic hydrocarbons present in chargrilled meat are substrates for inducible CYP1A and CYP3A enzymes and for P-glycoprotein. Polycyclic Aromatic Hydrocarbons 60-92 ATP binding cassette subfamily B member 1 Homo sapiens 182-196 10098502-10 1999 These results may explain the reported resistance of neonatal rat adrenals to the toxic effects of polycyclic aromatic hydrocarbons, which are metabolized by CYP1B1 into mutagenic by-products. Polycyclic Aromatic Hydrocarbons 99-131 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 158-164 10037450-1 1999 Polycyclic aromatic hydrocarbon (PAH)-type compounds induce at least two rat UDP-glucuronosyltransferase isoforms, UGT1A6 and UGT1A7. Polycyclic Aromatic Hydrocarbons 0-31 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 77-104 10101022-1 1999 Glucocorticoids repressed the polycyclic aromatic hydrocarbon-dependent induction of Class 3 aldehyde dehydrogenase (ALDH3) enzyme activity and mRNA levels in isolated rat hepatocytes by more than 50 to 80%, with a concentration-dependence consistent with the involvement of the glucocorticoid receptor (GR). Polycyclic Aromatic Hydrocarbons 30-61 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 117-122 10101022-1 1999 Glucocorticoids repressed the polycyclic aromatic hydrocarbon-dependent induction of Class 3 aldehyde dehydrogenase (ALDH3) enzyme activity and mRNA levels in isolated rat hepatocytes by more than 50 to 80%, with a concentration-dependence consistent with the involvement of the glucocorticoid receptor (GR). Polycyclic Aromatic Hydrocarbons 30-61 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 279-302 10101022-1 1999 Glucocorticoids repressed the polycyclic aromatic hydrocarbon-dependent induction of Class 3 aldehyde dehydrogenase (ALDH3) enzyme activity and mRNA levels in isolated rat hepatocytes by more than 50 to 80%, with a concentration-dependence consistent with the involvement of the glucocorticoid receptor (GR). Polycyclic Aromatic Hydrocarbons 30-61 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 304-306 10101022-3 1999 This effect of glucocorticoids (GC) on polycyclic aromatic hydrocarbon induction was effectively antagonized at the mRNA and protein level by the GR antagonist RU38486. Polycyclic Aromatic Hydrocarbons 39-70 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 146-148 10491856-4 1999 There is convincing epidemiological evidence that lung cancer risk associated with polycyclic aromatic hydrocarbons (PAHs) is mediated in part by aryl hydrocarbon hydroxylase (AHH), which is used as an indicator of the phenotype of CYP1A1. Polycyclic Aromatic Hydrocarbons 83-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 146-174 10491856-4 1999 There is convincing epidemiological evidence that lung cancer risk associated with polycyclic aromatic hydrocarbons (PAHs) is mediated in part by aryl hydrocarbon hydroxylase (AHH), which is used as an indicator of the phenotype of CYP1A1. Polycyclic Aromatic Hydrocarbons 83-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 176-179 10491856-4 1999 There is convincing epidemiological evidence that lung cancer risk associated with polycyclic aromatic hydrocarbons (PAHs) is mediated in part by aryl hydrocarbon hydroxylase (AHH), which is used as an indicator of the phenotype of CYP1A1. Polycyclic Aromatic Hydrocarbons 83-115 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 232-238 10491856-4 1999 There is convincing epidemiological evidence that lung cancer risk associated with polycyclic aromatic hydrocarbons (PAHs) is mediated in part by aryl hydrocarbon hydroxylase (AHH), which is used as an indicator of the phenotype of CYP1A1. Polycyclic Aromatic Hydrocarbons 117-121 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 146-174 10491856-4 1999 There is convincing epidemiological evidence that lung cancer risk associated with polycyclic aromatic hydrocarbons (PAHs) is mediated in part by aryl hydrocarbon hydroxylase (AHH), which is used as an indicator of the phenotype of CYP1A1. Polycyclic Aromatic Hydrocarbons 117-121 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 176-179 10491856-4 1999 There is convincing epidemiological evidence that lung cancer risk associated with polycyclic aromatic hydrocarbons (PAHs) is mediated in part by aryl hydrocarbon hydroxylase (AHH), which is used as an indicator of the phenotype of CYP1A1. Polycyclic Aromatic Hydrocarbons 117-121 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 232-238 10037450-1 1999 Polycyclic aromatic hydrocarbon (PAH)-type compounds induce at least two rat UDP-glucuronosyltransferase isoforms, UGT1A6 and UGT1A7. Polycyclic Aromatic Hydrocarbons 0-31 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 115-121 10037450-1 1999 Polycyclic aromatic hydrocarbon (PAH)-type compounds induce at least two rat UDP-glucuronosyltransferase isoforms, UGT1A6 and UGT1A7. Polycyclic Aromatic Hydrocarbons 0-31 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 126-132 10037450-1 1999 Polycyclic aromatic hydrocarbon (PAH)-type compounds induce at least two rat UDP-glucuronosyltransferase isoforms, UGT1A6 and UGT1A7. Polycyclic Aromatic Hydrocarbons 33-36 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 77-104 10037450-1 1999 Polycyclic aromatic hydrocarbon (PAH)-type compounds induce at least two rat UDP-glucuronosyltransferase isoforms, UGT1A6 and UGT1A7. Polycyclic Aromatic Hydrocarbons 33-36 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 115-121 10037450-1 1999 Polycyclic aromatic hydrocarbon (PAH)-type compounds induce at least two rat UDP-glucuronosyltransferase isoforms, UGT1A6 and UGT1A7. Polycyclic Aromatic Hydrocarbons 33-36 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 126-132 10037450-3 1999 Availability of AHH-1 cells stably expressing UGT1A7 allowed us to study whether this PAH-inducible isoform could catalyze benzo[a]pyrene and chrysene-3,6-diphenol glucuronidation. Polycyclic Aromatic Hydrocarbons 86-89 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 46-52 10037450-6 1999 Enzyme kinetic studies of the glucuronidation of 6-hydroxychrysene (used as a stable PAH phenol) indicated that UGT1A7 conjugated this compound with a lower apparent Km value (0.1 microM) than UGT1A6 (10 microM). Polycyclic Aromatic Hydrocarbons 85-88 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 112-118 10037450-7 1999 The results suggest that the two PAH-inducible UGTs may cooperate in conjugating PAH metabolites, but that UGT1A7 is more efficient. Polycyclic Aromatic Hydrocarbons 33-36 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 107-113 9888961-0 1999 Structure of peroxisomes and activity of the marker enzyme catalase in digestive epithelial cells in relation to PAH content of mussels from two Basque estuaries (Bay of Biscay): seasonal and site-specific variations. Polycyclic Aromatic Hydrocarbons 113-116 catalase Homo sapiens 59-67 11543061-3 1999 These features disappear with increasing distance from the central source, and they show striking similarities to recent laboratory data of PAH cations, providing the first identification of emission features arising specifically from ionized PAHs in the interstellar medium. Polycyclic Aromatic Hydrocarbons 243-247 phenylalanine hydroxylase Homo sapiens 140-143 9973208-0 1999 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Polycyclic Aromatic Hydrocarbons 61-93 dihydrodiol dehydrogenase Homo sapiens 217-242 9973208-0 1999 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Polycyclic Aromatic Hydrocarbons 95-99 dihydrodiol dehydrogenase Homo sapiens 217-242 9973208-0 1999 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Polycyclic Aromatic Hydrocarbons 95-98 dihydrodiol dehydrogenase Homo sapiens 217-242 9973208-1 1999 Human dihydrodiol dehydrogenase (DD) isoforms are aldo-keto reductases (AKRs) that activate polycyclic aromatic hydrocarbons (PAHs) by oxidizing trans-dihydrodiol proximate carcinogens to reactive and redox-active ortho-quinones. Polycyclic Aromatic Hydrocarbons 92-124 dihydrodiol dehydrogenase Homo sapiens 6-31 9973208-1 1999 Human dihydrodiol dehydrogenase (DD) isoforms are aldo-keto reductases (AKRs) that activate polycyclic aromatic hydrocarbons (PAHs) by oxidizing trans-dihydrodiol proximate carcinogens to reactive and redox-active ortho-quinones. Polycyclic Aromatic Hydrocarbons 126-130 dihydrodiol dehydrogenase Homo sapiens 6-31 9973208-10 1999 Thus, BPQ formation by AKR1C1 results in both a chemical (redox-cycling) and a genetic (AKR1C1 induction) amplification of ROS in PAH-exposed cells. Polycyclic Aromatic Hydrocarbons 130-133 aldo-keto reductase family 1 member C1 Homo sapiens 23-29 9973208-10 1999 Thus, BPQ formation by AKR1C1 results in both a chemical (redox-cycling) and a genetic (AKR1C1 induction) amplification of ROS in PAH-exposed cells. Polycyclic Aromatic Hydrocarbons 130-133 aldo-keto reductase family 1 member C1 Homo sapiens 88-94 10190573-0 1999 Potency of various polycyclic aromatic hydrocarbons as inducers of CYP1A1 in rat hepatocyte cultures. Polycyclic Aromatic Hydrocarbons 19-51 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 67-73 10190573-3 1999 Since a number of polycyclic aromatic hydrocarbons (PAHs) also act as AHR-agonists, the CYP1A1-inducing potencies, measured as induction of 7-ethoxyresorufin O-deethylase (EROD) activity in rat hepatocyte cultures were analyzed for 16 PAHs frequently present in environmental samples. Polycyclic Aromatic Hydrocarbons 52-56 aryl hydrocarbon receptor Rattus norvegicus 70-73 9920462-1 1998 Benzo[a]pyrene (BaP) and other polycyclic aromatic hydrocarbons (PAHs) which are present in cigarette smoke, are common air and food genotoxic contaminants and possible human carcinogens. Polycyclic Aromatic Hydrocarbons 31-63 prohibitin 2 Homo sapiens 16-19 10706243-0 1999 Protein tyrosine kinase activation by polycyclic aromatic hydrocarbons in human HPB-ALL T cells. Polycyclic Aromatic Hydrocarbons 38-70 EPH receptor A8 Homo sapiens 0-23 10706243-9 1999 We found that only immunotoxic PAHs activated the Fyn and ZAP-70 PTKs at 10 min, but total PTK activity was still increased by nonimmunotoxic PAHs, BeP, or anthracene after 10 min of exposure. Polycyclic Aromatic Hydrocarbons 31-35 FYN proto-oncogene, Src family tyrosine kinase Homo sapiens 50-53 10706243-9 1999 We found that only immunotoxic PAHs activated the Fyn and ZAP-70 PTKs at 10 min, but total PTK activity was still increased by nonimmunotoxic PAHs, BeP, or anthracene after 10 min of exposure. Polycyclic Aromatic Hydrocarbons 31-35 zeta chain of T cell receptor associated protein kinase 70 Homo sapiens 58-64 10706243-9 1999 We found that only immunotoxic PAHs activated the Fyn and ZAP-70 PTKs at 10 min, but total PTK activity was still increased by nonimmunotoxic PAHs, BeP, or anthracene after 10 min of exposure. Polycyclic Aromatic Hydrocarbons 31-35 protein tyrosine kinase 2 beta Homo sapiens 65-68 10706243-10 1999 These studies demonstrate that immunotoxic PAHs increase total and specific PTK activity in the human HPB-ALL T cell line. Polycyclic Aromatic Hydrocarbons 43-47 protein tyrosine kinase 2 beta Homo sapiens 76-79 10706243-11 1999 Thus the rapid increase in PTK activity produced by PAHs may not correlate with the immunotoxicity of these agents. Polycyclic Aromatic Hydrocarbons 52-56 protein tyrosine kinase 2 beta Homo sapiens 27-30 9881702-1 1998 Sequence-dependent formation and lack of repair of polycyclic aromatic hydrocarbon-induced DNA adducts correlates well with the positions of p53 mutational hotspots in smoking-related lung cancers (Denissenko et al, 1996, 1998). Polycyclic Aromatic Hydrocarbons 51-82 tumor protein p53 Homo sapiens 141-144 9850062-11 1998 In conclusion, our results suggest that hGSTP1-1 polymorphism may be an important factor in differential susceptibility of humans to cancers where polycyclic aromatic hydrocarbons are etiological factors and that I104,A113 variant may play a major role in the detoxification of nonplanar, sterically hindered fjord-region diol epoxides (e.g., anti-BGCDE). Polycyclic Aromatic Hydrocarbons 147-179 glutathione S-transferase pi 1 Homo sapiens 40-48 9836706-1 1998 Cytochrome P450 (CYP) 1B1 activates polycyclic aromatic hydrocarbons and aryl aromatic hydrocarbons to carcinogens. Polycyclic Aromatic Hydrocarbons 36-68 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-25 9860927-1 1998 The aryl hydrocarbon receptor (AHR) is believed to mediate the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polychlorinated biphenyls, and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 155-187 aryl-hydrocarbon receptor Mus musculus 4-29 9860927-1 1998 The aryl hydrocarbon receptor (AHR) is believed to mediate the toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), polychlorinated biphenyls, and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 155-187 aryl-hydrocarbon receptor Mus musculus 31-34 10378478-5 1999 Results from the whole-cell ER binding assay and the radiometric analysis of E2 metabolism indicate that the PAHs detected in the KC and the SLR environmental samples induce antiestrogenic responses in metabolically intact human breast cancer cells through at least two mechanisms: one involving competition for the ER by a PAH metabolite and the other involving depletion of E2 through induction of metabolism. Polycyclic Aromatic Hydrocarbons 109-113 estrogen receptor 1 Homo sapiens 28-30 10378478-5 1999 Results from the whole-cell ER binding assay and the radiometric analysis of E2 metabolism indicate that the PAHs detected in the KC and the SLR environmental samples induce antiestrogenic responses in metabolically intact human breast cancer cells through at least two mechanisms: one involving competition for the ER by a PAH metabolite and the other involving depletion of E2 through induction of metabolism. Polycyclic Aromatic Hydrocarbons 109-112 estrogen receptor 1 Homo sapiens 28-30 10331078-1 1999 Cytochrome P4501A1 is a substrate-inducible microsomal enzyme that oxygenates polycyclic aromatic hydrocarbons, such as the carcinogen benzo(a)pyrene, as the initial step in their metabolic processing to water-soluble derivatives. Polycyclic Aromatic Hydrocarbons 78-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 9950238-1 1999 In experimental systems, polychlorinated biphenyls (PCBs) induce cytochrome P4501A1 (CYP1A1), which is involved in metabolism of steroid hormones and polycyclic aromatic hydrocarbons in humans. Polycyclic Aromatic Hydrocarbons 150-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-83 9950238-1 1999 In experimental systems, polychlorinated biphenyls (PCBs) induce cytochrome P4501A1 (CYP1A1), which is involved in metabolism of steroid hormones and polycyclic aromatic hydrocarbons in humans. Polycyclic Aromatic Hydrocarbons 150-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 85-91 9920462-1 1998 Benzo[a]pyrene (BaP) and other polycyclic aromatic hydrocarbons (PAHs) which are present in cigarette smoke, are common air and food genotoxic contaminants and possible human carcinogens. Polycyclic Aromatic Hydrocarbons 65-69 prohibitin 2 Homo sapiens 16-19 9920462-9 1998 This study further confirms the usefulness of BPDE-DNA adduct levels determination in the lungs from autopsy samples for monitoring long-term human exposure to BaP, a representative PAH. Polycyclic Aromatic Hydrocarbons 182-185 prohibitin 2 Homo sapiens 160-163 9827546-2 1998 This study reports the catalytic efficiencies (k(cat)/Km) of two naturally occurring variants, GSTP1-1/I-105 and GSTP1-1/ V-105, towards a series of fjord-region diol epoxides representing potent biologically active PAH metabolites, and two GSTP1-1 mutants with Ala105 and Trp105 in the active site. Polycyclic Aromatic Hydrocarbons 216-219 glutathione S-transferase pi 1 Homo sapiens 95-102 9827546-2 1998 This study reports the catalytic efficiencies (k(cat)/Km) of two naturally occurring variants, GSTP1-1/I-105 and GSTP1-1/ V-105, towards a series of fjord-region diol epoxides representing potent biologically active PAH metabolites, and two GSTP1-1 mutants with Ala105 and Trp105 in the active site. Polycyclic Aromatic Hydrocarbons 216-219 glutathione S-transferase pi 1 Homo sapiens 113-120 9827546-2 1998 This study reports the catalytic efficiencies (k(cat)/Km) of two naturally occurring variants, GSTP1-1/I-105 and GSTP1-1/ V-105, towards a series of fjord-region diol epoxides representing potent biologically active PAH metabolites, and two GSTP1-1 mutants with Ala105 and Trp105 in the active site. Polycyclic Aromatic Hydrocarbons 216-219 glutathione S-transferase pi 1 Homo sapiens 113-120 9827546-3 1998 The results indicate that individuals who are homozygous for the allele encoding GSTP1-1/V-105 might be more susceptible to PAH carcinogenesis due to other reasons than a reduced capacity for detoxifying diol epoxides. Polycyclic Aromatic Hydrocarbons 124-127 glutathione S-transferase pi 1 Homo sapiens 81-88 9855012-10 1998 This study demonstrates that differences in the caalytic activity seen for purified GST towards individual mutagens do not necessarily reflect the detoxification of DEs by the same enzyme in a living cell and provides further evidence that specific human GSTs play a role in the detoxification of DEs of PAHs. Polycyclic Aromatic Hydrocarbons 304-308 glutathione S-transferase pi 1 Homo sapiens 255-259 9804617-1 1998 Cytochrome P450 1B1 (CYP1B1), which actively metabolizes polycyclic aromatic hydrocarbons, is regulated by the aryl hydrocarbon receptor (AhR) in primary cultures of rat mammary fibroblasts (RMF) and rat embryo fibroblasts (REF). Polycyclic Aromatic Hydrocarbons 57-89 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 0-19 9804617-1 1998 Cytochrome P450 1B1 (CYP1B1), which actively metabolizes polycyclic aromatic hydrocarbons, is regulated by the aryl hydrocarbon receptor (AhR) in primary cultures of rat mammary fibroblasts (RMF) and rat embryo fibroblasts (REF). Polycyclic Aromatic Hydrocarbons 57-89 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 21-27 9804617-1 1998 Cytochrome P450 1B1 (CYP1B1), which actively metabolizes polycyclic aromatic hydrocarbons, is regulated by the aryl hydrocarbon receptor (AhR) in primary cultures of rat mammary fibroblasts (RMF) and rat embryo fibroblasts (REF). Polycyclic Aromatic Hydrocarbons 57-89 aryl hydrocarbon receptor Rattus norvegicus 111-136 9804617-1 1998 Cytochrome P450 1B1 (CYP1B1), which actively metabolizes polycyclic aromatic hydrocarbons, is regulated by the aryl hydrocarbon receptor (AhR) in primary cultures of rat mammary fibroblasts (RMF) and rat embryo fibroblasts (REF). Polycyclic Aromatic Hydrocarbons 57-89 aryl hydrocarbon receptor Rattus norvegicus 138-141 9752993-3 1998 Epidemiological studies have shown that P4501A1 (CYP1A1) genotypes are associated with PAH-related lung cancer risk. Polycyclic Aromatic Hydrocarbons 87-90 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 9763411-2 1998 UDP-glucuronosyltransferase (UGT) 1A6 is an important catalyst for phenol and polycyclic aromatic hydrocarbon glucuronidation. Polycyclic Aromatic Hydrocarbons 78-109 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 0-37 10323327-2 1998 ALDHI is mainly increased by phenobarbital-type inducers; polycyclic aromatic hydrocarbons (PAHs), such as 3- methylcholanthrene (3MC), increase ALDH3c enzyme activity in all rat species currently tested. Polycyclic Aromatic Hydrocarbons 58-90 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 145-150 10323327-2 1998 ALDHI is mainly increased by phenobarbital-type inducers; polycyclic aromatic hydrocarbons (PAHs), such as 3- methylcholanthrene (3MC), increase ALDH3c enzyme activity in all rat species currently tested. Polycyclic Aromatic Hydrocarbons 92-96 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 145-150 9800384-1 1998 The objective of this study was to analyze the effect of the GSTM1 and GSTP1 genotypes on urinary 1-hydroxypyrene, a biomarker for exposure to polycyclic aromatic hydrocarbon. Polycyclic Aromatic Hydrocarbons 143-174 glutathione S-transferase mu 1 Homo sapiens 61-66 9800384-1 1998 The objective of this study was to analyze the effect of the GSTM1 and GSTP1 genotypes on urinary 1-hydroxypyrene, a biomarker for exposure to polycyclic aromatic hydrocarbon. Polycyclic Aromatic Hydrocarbons 143-174 glutathione S-transferase pi 1 Homo sapiens 71-76 9670973-0 1998 Macrophage activation by polycyclic aromatic hydrocarbons: evidence for the involvement of stress-activated protein kinases, activator protein-1, and antioxidant response elements. Polycyclic Aromatic Hydrocarbons 25-57 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 125-144 11013725-0 1998 SFE plus C18 lipid cleanup method for selective extraction and GC/MS quantitation of polycyclic aromatic hydrocarbons in biological tissues. Polycyclic Aromatic Hydrocarbons 85-117 Bardet-Biedl syndrome 9 Homo sapiens 9-12 9687573-1 1998 The aryl hydrocarbon receptor (AHR) is believed to mediate many of the toxic, carcinogenic, and teratogenic effects of environmental contaminants such as dioxins, polycyclic aromatic hydrocarbons, and polyhalogenated biphenyls. Polycyclic Aromatic Hydrocarbons 163-195 aryl-hydrocarbon receptor Mus musculus 4-29 9687573-1 1998 The aryl hydrocarbon receptor (AHR) is believed to mediate many of the toxic, carcinogenic, and teratogenic effects of environmental contaminants such as dioxins, polycyclic aromatic hydrocarbons, and polyhalogenated biphenyls. Polycyclic Aromatic Hydrocarbons 163-195 aryl-hydrocarbon receptor Mus musculus 31-34 9707513-10 1998 Furthermore, the effects on increased Bax expression were observed as early as 3 h after PAH exposure. Polycyclic Aromatic Hydrocarbons 89-92 BCL2 associated X, apoptosis regulator Homo sapiens 38-41 9707513-15 1998 Bcl-2 expression was most responsive to ANF at later time points following PAH exposure (18 and 36 h); however, Bcl-2 appeared to be more sensitive to the effects of ANF alone. Polycyclic Aromatic Hydrocarbons 75-78 BCL2 apoptosis regulator Homo sapiens 0-5 9744530-1 1998 Cytochrome P4501A1 (CYP1A1) has been implicated in the conversion of numerous polycyclic aromatic hydrocarbons into electrophilic species capable of binding covalently to DNA and has therefore been postulated to be involved in the initiation of carcinogenesis. Polycyclic Aromatic Hydrocarbons 78-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 9744530-1 1998 Cytochrome P4501A1 (CYP1A1) has been implicated in the conversion of numerous polycyclic aromatic hydrocarbons into electrophilic species capable of binding covalently to DNA and has therefore been postulated to be involved in the initiation of carcinogenesis. Polycyclic Aromatic Hydrocarbons 78-110 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 9744534-0 1998 Polycyclic aromatic hydrocarbon-DNA adducts in human placenta and modulation by CYP1A1 induction and genotype. Polycyclic Aromatic Hydrocarbons 0-31 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 80-86 9670973-2 1998 A key question is: what are molecular pathways in the immune system by which PAH and conversion products drive allergic inflammation? Polycyclic Aromatic Hydrocarbons 77-80 stabilin 2 Homo sapiens 24-27 9670973-3 1998 Circumstantial evidence suggests that macrophages are involved in PAH-induced responses. Polycyclic Aromatic Hydrocarbons 66-69 stabilin 2 Homo sapiens 50-53 9670973-4 1998 We demonstrate that a representative PAH, beta-napthoflavone (BNF), and a representative quinone metabolite, tert-butylhydroxyquinone (tBHQ), induce Jun kinase and p38 mitogen-activated protein kinase activities in parallel with the generation of activator protein-1 (AP-1) mobility shift complexes in THP-1 and RAW264.7 macrophage cell lines. Polycyclic Aromatic Hydrocarbons 37-40 mitogen-activated protein kinase 9 Homo sapiens 149-159 9670973-4 1998 We demonstrate that a representative PAH, beta-napthoflavone (BNF), and a representative quinone metabolite, tert-butylhydroxyquinone (tBHQ), induce Jun kinase and p38 mitogen-activated protein kinase activities in parallel with the generation of activator protein-1 (AP-1) mobility shift complexes in THP-1 and RAW264.7 macrophage cell lines. Polycyclic Aromatic Hydrocarbons 37-40 mitogen-activated protein kinase 14 Homo sapiens 164-167 9670973-4 1998 We demonstrate that a representative PAH, beta-napthoflavone (BNF), and a representative quinone metabolite, tert-butylhydroxyquinone (tBHQ), induce Jun kinase and p38 mitogen-activated protein kinase activities in parallel with the generation of activator protein-1 (AP-1) mobility shift complexes in THP-1 and RAW264.7 macrophage cell lines. Polycyclic Aromatic Hydrocarbons 37-40 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 247-266 9670973-4 1998 We demonstrate that a representative PAH, beta-napthoflavone (BNF), and a representative quinone metabolite, tert-butylhydroxyquinone (tBHQ), induce Jun kinase and p38 mitogen-activated protein kinase activities in parallel with the generation of activator protein-1 (AP-1) mobility shift complexes in THP-1 and RAW264.7 macrophage cell lines. Polycyclic Aromatic Hydrocarbons 37-40 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 268-272 9670973-4 1998 We demonstrate that a representative PAH, beta-napthoflavone (BNF), and a representative quinone metabolite, tert-butylhydroxyquinone (tBHQ), induce Jun kinase and p38 mitogen-activated protein kinase activities in parallel with the generation of activator protein-1 (AP-1) mobility shift complexes in THP-1 and RAW264.7 macrophage cell lines. Polycyclic Aromatic Hydrocarbons 37-40 GLI family zinc finger 2 Homo sapiens 302-307 9659573-6 1998 Ki-ras codon 12 and 61 mutation analysis of PAH induced tumors was performed using PCR and dideoxy sequencing methods. Polycyclic Aromatic Hydrocarbons 44-47 Kirsten rat sarcoma viral oncogene homolog Mus musculus 0-6 9639391-1 1998 Cytochrome P4501A1 (CYP1A1) is involved in the bioactivation of polycyclic aromatic hydrocarbons into their reactive epoxide metabolites. Polycyclic Aromatic Hydrocarbons 64-96 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 9639391-1 1998 Cytochrome P4501A1 (CYP1A1) is involved in the bioactivation of polycyclic aromatic hydrocarbons into their reactive epoxide metabolites. Polycyclic Aromatic Hydrocarbons 64-96 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 9659573-1 1998 This paper describes a series of studies on the lung tumorigenic activities of polycyclic aromatic hydrocarbons (PAHs) in strain A/J mice, their ability to form PAH-DNA adducts in lung tissues, and their ability to mutate the Ki-ras oncogene in PAH-induced tumors. Polycyclic Aromatic Hydrocarbons 79-111 Kirsten rat sarcoma viral oncogene homolog Mus musculus 226-232 9659573-1 1998 This paper describes a series of studies on the lung tumorigenic activities of polycyclic aromatic hydrocarbons (PAHs) in strain A/J mice, their ability to form PAH-DNA adducts in lung tissues, and their ability to mutate the Ki-ras oncogene in PAH-induced tumors. Polycyclic Aromatic Hydrocarbons 113-117 Kirsten rat sarcoma viral oncogene homolog Mus musculus 226-232 9671400-2 1998 Papillomas induced by the most carcinogenic environmental polycyclic aromatic hydrocarbon (PAH), dibenzo[a,l]pyrene (DB[a,l]P), in SENCAR mouse skin contain a specific H-ras codon 61 (CAA-->CTA) mutation. Polycyclic Aromatic Hydrocarbons 58-89 Harvey rat sarcoma virus oncogene Mus musculus 168-173 9622076-0 1998 Characterization of CYP1B1 and CYP1A1 expression in human mammary epithelial cells: role of the aryl hydrocarbon receptor in polycyclic aromatic hydrocarbon metabolism. Polycyclic Aromatic Hydrocarbons 125-156 aryl hydrocarbon receptor Homo sapiens 96-121 9622076-13 1998 This study indicates that CYP1B1 is an important activator of polycyclic aromatic hydrocarbons in the mammary gland when environmental chemical exposures minimally induce CYP1A1. Polycyclic Aromatic Hydrocarbons 62-94 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 26-32 9622076-13 1998 This study indicates that CYP1B1 is an important activator of polycyclic aromatic hydrocarbons in the mammary gland when environmental chemical exposures minimally induce CYP1A1. Polycyclic Aromatic Hydrocarbons 62-94 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 171-177 9622076-14 1998 Additionally, certain individuals express low levels of basal CYP1A1 in HMECs, representing a potential risk factor of mammary carcinogenesis through enhanced polycyclic aromatic hydrocarbon bioactivation. Polycyclic Aromatic Hydrocarbons 159-190 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-68 9667743-2 1998 The present study utilized a pharmacogenetic mouse model to assess the role of cytochrome P4501A1 (Cyp1a1) in modulating genetic damage to oncogenic and tumor suppressor loci following in utero exposure to the polycyclic aromatic hydrocarbon, 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons 210-241 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 79-97 9667743-2 1998 The present study utilized a pharmacogenetic mouse model to assess the role of cytochrome P4501A1 (Cyp1a1) in modulating genetic damage to oncogenic and tumor suppressor loci following in utero exposure to the polycyclic aromatic hydrocarbon, 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons 210-241 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 99-105 9655246-0 1998 Linear amplification mapping of polycyclic aromatic hydrocarbon-reactive sequences in H-ras gene. Polycyclic Aromatic Hydrocarbons 32-63 HRas proto-oncogene, GTPase Homo sapiens 86-91 9655246-7 1998 The results indicate that the central A of H-ras codon 61 (CAA) reacts with these polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 82-114 HRas proto-oncogene, GTPase Homo sapiens 43-48 9670973-6 1998 Another genetic response pathway linked to PAH is the antioxidant response element (ARE), which regulates expression of detoxifying enzymes. Polycyclic Aromatic Hydrocarbons 43-46 stabilin 2 Homo sapiens 84-87 9670973-10 1998 This suggests that PAH and their conversion products operate via ARE-specific transcription factors in the immune system. Polycyclic Aromatic Hydrocarbons 19-22 stabilin 2 Homo sapiens 65-68 9717460-3 1998 Polycyclic aromatic hydrocarbons regulate the gene expression by binding the cytosolic aryl hydrocarbon receptor and its translocation to the nucleus where it forms a ternary complex with aryl hydrocarbon nuclear translocator. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 87-112 9586956-0 1998 Inhibition of CYP1A1-dependent activity by the polynuclear aromatic hydrocarbon (PAH) fluoranthene. Polycyclic Aromatic Hydrocarbons 81-84 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 14-20 9586956-0 1998 Inhibition of CYP1A1-dependent activity by the polynuclear aromatic hydrocarbon (PAH) fluoranthene. Polycyclic Aromatic Hydrocarbons 47-79 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 14-20 9578563-2 1998 Previous studies demonstrated that rat liver 3 alpha-hydroxysteroid dehydrogenase/dihydrodiol dehydrogenase (3 alpha-HSD/DD), a member of the aldo-keto reductase (AKR) superfamily, oxidizes PAH trans-dihydrodiols to redox-cycling o-quinones. Polycyclic Aromatic Hydrocarbons 190-193 aldo-keto reductase family 1, member C14 Rattus norvegicus 45-81 9525277-3 1998 In the present study the catalytic efficiencies (kcat/Km) of these GSTP1-1 variants were determined with a number of stereoisomeric bay-region diol epoxides, known as the ultimate mutagenic and carcinogenic metabolites of PAH, including those from chrysene, benzo[a]pyrene and dibenz[a,h]anthracene. Polycyclic Aromatic Hydrocarbons 222-225 glutathione S-transferase pi 1 Homo sapiens 67-74 9525277-5 1998 GSTP1-1/V-105 was found to be more active than GSTP1-1/I-105 in conjugation reactions with the bulky diol epoxides of PAH, being up to 3-fold as active towards the anti- and syn-diol epoxide enantiomers with R-absolute configuration at the benzylic oxiranyl carbon. Polycyclic Aromatic Hydrocarbons 118-121 glutathione S-transferase pi 1 Homo sapiens 0-7 9525277-5 1998 GSTP1-1/V-105 was found to be more active than GSTP1-1/I-105 in conjugation reactions with the bulky diol epoxides of PAH, being up to 3-fold as active towards the anti- and syn-diol epoxide enantiomers with R-absolute configuration at the benzylic oxiranyl carbon. Polycyclic Aromatic Hydrocarbons 118-121 glutathione S-transferase pi 1 Homo sapiens 47-54 9525277-5 1998 GSTP1-1/V-105 was found to be more active than GSTP1-1/I-105 in conjugation reactions with the bulky diol epoxides of PAH, being up to 3-fold as active towards the anti- and syn-diol epoxide enantiomers with R-absolute configuration at the benzylic oxiranyl carbon. Polycyclic Aromatic Hydrocarbons 118-121 synemin Homo sapiens 174-177 9525277-11 1998 In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH. Polycyclic Aromatic Hydrocarbons 348-351 glutathione S-transferase pi 1 Homo sapiens 94-99 9525277-11 1998 In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH. Polycyclic Aromatic Hydrocarbons 348-351 glutathione S-transferase pi 1 Homo sapiens 115-122 9525277-11 1998 In conclusion, the present study indicates that individuals who are homozygous for the allele GSTP1* B (coding for GSTP1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP1-1/V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH. Polycyclic Aromatic Hydrocarbons 348-351 glutathione S-transferase pi 1 Homo sapiens 242-249 9495812-1 1998 Rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD), a member of the aldo-keto reductase superfamily, inactivates circulating steroid hormones and may contribute to the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs) by oxidizing trans-dihydrodiols to reactive o-quinones with the concomitant generation of reactive oxygen species. Polycyclic Aromatic Hydrocarbons 210-242 aldo-keto reductase family 1, member C14 Rattus norvegicus 59-69 9495812-1 1998 Rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (3alpha-HSD/DD), a member of the aldo-keto reductase superfamily, inactivates circulating steroid hormones and may contribute to the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs) by oxidizing trans-dihydrodiols to reactive o-quinones with the concomitant generation of reactive oxygen species. Polycyclic Aromatic Hydrocarbons 244-248 aldo-keto reductase family 1, member C14 Rattus norvegicus 59-69 9586956-2 1998 Induction of CYP1A1-dependent activity in H4IIE rat hepatoma cells has been used extensively as a bioassay for halogenated aromatic hydrocarbons and more recently for PAHs. Polycyclic Aromatic Hydrocarbons 167-171 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 13-19 9586956-9 1998 This study demonstrated that FL is an inhibitor of CYP1A1-dependent enzyme activity in rat hepatoma H4IIE cells and that the genotoxic potency of some carcinogenic PAHs may be modulated by FL in mixtures containing relatively high levels of this compound. Polycyclic Aromatic Hydrocarbons 164-168 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 51-57 9488590-11 1998 These findings are suggestive of a gene-environment interaction, in which subjects with the CYP1A1 polymorphism, relative to subjects without it, have higher levels of 1-OH-P in their urine at low doses of exposure to PAHs. Polycyclic Aromatic Hydrocarbons 218-222 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 92-98 10026994-9 1998 Further genetic analyses confirmed that the combination of CYP1A1 homozygous mutants and GSTM1 inactive leads to high levels of BPDE-DNA adducts in human lung of smokers and white blood cells of PAH-exposed coke oven workers. Polycyclic Aromatic Hydrocarbons 195-198 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 59-65 9538942-1 1998 The induction of cytochrome P4501A (CYP1A1) enzyme activity is one of the best-studied direct effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds and has been shown to be a sensitive biomarker of exposure to polycyclic aromatic hydrocarbons (PAH) in different experimental animal species as well as in humans. Polycyclic Aromatic Hydrocarbons 232-264 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 9538942-1 1998 The induction of cytochrome P4501A (CYP1A1) enzyme activity is one of the best-studied direct effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds and has been shown to be a sensitive biomarker of exposure to polycyclic aromatic hydrocarbons (PAH) in different experimental animal species as well as in humans. Polycyclic Aromatic Hydrocarbons 266-269 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 9762354-1 1998 Transcriptional regulation and function of rat and human PAH-inducible UDP-glucuronosyltransferase (UGT) isoforms have been studied. Polycyclic Aromatic Hydrocarbons 57-60 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 71-98 9762354-1 1998 Transcriptional regulation and function of rat and human PAH-inducible UDP-glucuronosyltransferase (UGT) isoforms have been studied. Polycyclic Aromatic Hydrocarbons 57-60 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 100-103 9762354-3 1998 At least two PAH-inducible UGT isoforms are expressed in a variety of tissues, the rat isoforms UGT1A6 and UGT1A7, and the human isoforms UGT1A6 and UGT1A9. Polycyclic Aromatic Hydrocarbons 13-16 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 27-30 9762354-3 1998 At least two PAH-inducible UGT isoforms are expressed in a variety of tissues, the rat isoforms UGT1A6 and UGT1A7, and the human isoforms UGT1A6 and UGT1A9. Polycyclic Aromatic Hydrocarbons 13-16 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 96-102 9762354-3 1998 At least two PAH-inducible UGT isoforms are expressed in a variety of tissues, the rat isoforms UGT1A6 and UGT1A7, and the human isoforms UGT1A6 and UGT1A9. Polycyclic Aromatic Hydrocarbons 13-16 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 107-113 9762354-3 1998 At least two PAH-inducible UGT isoforms are expressed in a variety of tissues, the rat isoforms UGT1A6 and UGT1A7, and the human isoforms UGT1A6 and UGT1A9. Polycyclic Aromatic Hydrocarbons 13-16 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 138-144 9762354-3 1998 At least two PAH-inducible UGT isoforms are expressed in a variety of tissues, the rat isoforms UGT1A6 and UGT1A7, and the human isoforms UGT1A6 and UGT1A9. Polycyclic Aromatic Hydrocarbons 13-16 UDP glucuronosyltransferase family 1 member A9 Homo sapiens 149-155 9762354-5 1998 For the rat and human UGT1A6 isoforms two modes of tissue- and cell-specific regulation were found, PAH-inducible and constitutive expression. Polycyclic Aromatic Hydrocarbons 100-103 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 22-28 9762354-7 1998 Transient transfection studies, using human UGT1A6/CAT fusion constructs and colon carcinoma Caco-2 cells, revealed that PAH induction of human UGT1A6 is mediated by the Ah receptor. Polycyclic Aromatic Hydrocarbons 121-124 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 44-50 9762354-7 1998 Transient transfection studies, using human UGT1A6/CAT fusion constructs and colon carcinoma Caco-2 cells, revealed that PAH induction of human UGT1A6 is mediated by the Ah receptor. Polycyclic Aromatic Hydrocarbons 121-124 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 144-150 9762354-9 1998 Cell-expressed UGT isoforms were used to study their function in PAH metabolism. Polycyclic Aromatic Hydrocarbons 65-68 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 15-18 9762354-10 1998 Rat UGT1A7 and human UGT1A9 appear to be more efficient than the corresponding UGT1A6 isoforms in catalyzing glucuronide formation of PAH phenols and diphenols. Polycyclic Aromatic Hydrocarbons 134-137 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 4-10 9762354-10 1998 Rat UGT1A7 and human UGT1A9 appear to be more efficient than the corresponding UGT1A6 isoforms in catalyzing glucuronide formation of PAH phenols and diphenols. Polycyclic Aromatic Hydrocarbons 134-137 UDP glucuronosyltransferase family 1 member A9 Homo sapiens 21-27 9762354-10 1998 Rat UGT1A7 and human UGT1A9 appear to be more efficient than the corresponding UGT1A6 isoforms in catalyzing glucuronide formation of PAH phenols and diphenols. Polycyclic Aromatic Hydrocarbons 134-137 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 79-85 9762354-13 1998 They also suggest a major role of these UGT isoforms in detoxication of PAHs. Polycyclic Aromatic Hydrocarbons 72-76 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 40-43 9442307-6 1998 At the biochemical level the tests can indicate that the organism has been exposed to certain groups of chemicals (for example cytochrome P-450 enzymes responding to PAHs or metallothioneins responding to heavy metals). Polycyclic Aromatic Hydrocarbons 166-170 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 127-143 23899393-0 1998 Influence of GSTM1 and NAT2 genotypes on the relationship between personal exposure to PAH and biomarkers of internal dose. Polycyclic Aromatic Hydrocarbons 87-90 glutathione S-transferase mu 1 Homo sapiens 13-18 23899393-0 1998 Influence of GSTM1 and NAT2 genotypes on the relationship between personal exposure to PAH and biomarkers of internal dose. Polycyclic Aromatic Hydrocarbons 87-90 N-acetyltransferase 2 Homo sapiens 23-27 23899393-4 1998 After stratifying by genetic polymorphism the correlation between personal PAH exposure and urinary PAH metabolites increased for individuals with NAT2 slow acetylators (r 0.58, p 0.001, n 29) and the combination of GSTM1 null and NAT2 slow acetylators (r 0.60, p 0.01, n 16). Polycyclic Aromatic Hydrocarbons 75-78 N-acetyltransferase 2 Homo sapiens 147-151 23899393-4 1998 After stratifying by genetic polymorphism the correlation between personal PAH exposure and urinary PAH metabolites increased for individuals with NAT2 slow acetylators (r 0.58, p 0.001, n 29) and the combination of GSTM1 null and NAT2 slow acetylators (r 0.60, p 0.01, n 16). Polycyclic Aromatic Hydrocarbons 75-78 glutathione S-transferase mu 1 Homo sapiens 216-221 23899393-4 1998 After stratifying by genetic polymorphism the correlation between personal PAH exposure and urinary PAH metabolites increased for individuals with NAT2 slow acetylators (r 0.58, p 0.001, n 29) and the combination of GSTM1 null and NAT2 slow acetylators (r 0.60, p 0.01, n 16). Polycyclic Aromatic Hydrocarbons 75-78 N-acetyltransferase 2 Homo sapiens 231-235 23899393-4 1998 After stratifying by genetic polymorphism the correlation between personal PAH exposure and urinary PAH metabolites increased for individuals with NAT2 slow acetylators (r 0.58, p 0.001, n 29) and the combination of GSTM1 null and NAT2 slow acetylators (r 0.60, p 0.01, n 16). Polycyclic Aromatic Hydrocarbons 100-103 N-acetyltransferase 2 Homo sapiens 147-151 23899393-4 1998 After stratifying by genetic polymorphism the correlation between personal PAH exposure and urinary PAH metabolites increased for individuals with NAT2 slow acetylators (r 0.58, p 0.001, n 29) and the combination of GSTM1 null and NAT2 slow acetylators (r 0.60, p 0.01, n 16). Polycyclic Aromatic Hydrocarbons 100-103 glutathione S-transferase mu 1 Homo sapiens 216-221 23899393-4 1998 After stratifying by genetic polymorphism the correlation between personal PAH exposure and urinary PAH metabolites increased for individuals with NAT2 slow acetylators (r 0.58, p 0.001, n 29) and the combination of GSTM1 null and NAT2 slow acetylators (r 0.60, p 0.01, n 16). Polycyclic Aromatic Hydrocarbons 100-103 N-acetyltransferase 2 Homo sapiens 231-235 10026994-9 1998 Further genetic analyses confirmed that the combination of CYP1A1 homozygous mutants and GSTM1 inactive leads to high levels of BPDE-DNA adducts in human lung of smokers and white blood cells of PAH-exposed coke oven workers. Polycyclic Aromatic Hydrocarbons 195-198 glutathione S-transferase mu 1 Homo sapiens 89-94 9403173-0 1997 Glutathione conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1-1 and P1-1. Polycyclic Aromatic Hydrocarbons 66-98 S100 calcium binding protein A10 Homo sapiens 127-140 9463278-5 1997 The UGT1A71 RNA is expressed in both neonatal and adult liver, and unlike rat UGT1A2 which is inducible with Ah receptor ligands such as polycyclic aromatic hydrocarbons, rabbit UGT1A7 is not regulated when animals are exposed to these inducers. Polycyclic Aromatic Hydrocarbons 137-169 UDP glucuronosyltransferase 1 family, polypeptide A2 Rattus norvegicus 78-84 9463278-5 1997 The UGT1A71 RNA is expressed in both neonatal and adult liver, and unlike rat UGT1A2 which is inducible with Ah receptor ligands such as polycyclic aromatic hydrocarbons, rabbit UGT1A7 is not regulated when animals are exposed to these inducers. Polycyclic Aromatic Hydrocarbons 137-169 UDP glucuronosyltransferase 1 family, polypeptide A7 Oryctolagus cuniculus 4-10 9367523-7 1997 These characteristics in addition to inhibition by antibodies raised to recCYP1B1m establish that the CYP1B1 cDNA indeed encodes the P450 responsible for polycyclic aromatic hydrocarbon (PAH) metabolism from C3H10T1/2 cells. Polycyclic Aromatic Hydrocarbons 154-185 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 75-81 9367523-7 1997 These characteristics in addition to inhibition by antibodies raised to recCYP1B1m establish that the CYP1B1 cDNA indeed encodes the P450 responsible for polycyclic aromatic hydrocarbon (PAH) metabolism from C3H10T1/2 cells. Polycyclic Aromatic Hydrocarbons 187-190 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 75-81 9148793-5 1997 In addition, OH, NO3, and O3 are shown to play a central role in the formation and fate of airborne toxic chemicals, mutagenic polycyclic aromatic hydrocarbons, and fine particles. Polycyclic Aromatic Hydrocarbons 127-159 NBL1, DAN family BMP antagonist Homo sapiens 17-20 9300049-0 1997 Polycyclic aromatic hydrocarbon (PAH)-binding protein and glycine N-methyltransferase (GNMT) Polycyclic Aromatic Hydrocarbons 0-31 glycine N-methyltransferase Homo sapiens 87-91 9299744-2 1997 In this paper we have studied SPE discs with a glass fiber matrix (SPE disc GFM) to extract PAHs from aqueous samples, which have then been separated and detected with high-performance liquid chromatography-fluorescence detection. Polycyclic Aromatic Hydrocarbons 92-96 G elongation factor mitochondrial 1 Homo sapiens 76-79 9264550-5 1997 The UGT1A7l RNA is expressed in both neonatal and adult liver, and unlike rat UGT1A2 which is inducible with Ah receptor ligands such as polycyclic aromatic hydrocarbons, rabbit UGT1A7l is not regulated when animals are exposed to these inducers. Polycyclic Aromatic Hydrocarbons 137-169 UDP glucuronosyltransferase 1 family, polypeptide A2 Rattus norvegicus 78-84 9245423-1 1997 In the rat, cytochrome P4501A1 gene expression is thought to be regulated by several trans-acting factors including the 4S polycyclic aromatic hydrocarbon (PAH)-binding protein, which was recently identified as glycine N-methyltransferase [Raha, A., Wagner, C., MacDonald, R. G., and Bresnick, E. (1994) J. Biol. Polycyclic Aromatic Hydrocarbons 123-154 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 12-30 9245423-1 1997 In the rat, cytochrome P4501A1 gene expression is thought to be regulated by several trans-acting factors including the 4S polycyclic aromatic hydrocarbon (PAH)-binding protein, which was recently identified as glycine N-methyltransferase [Raha, A., Wagner, C., MacDonald, R. G., and Bresnick, E. (1994) J. Biol. Polycyclic Aromatic Hydrocarbons 123-154 glycine N-methyltransferase Rattus norvegicus 211-238 9245423-1 1997 In the rat, cytochrome P4501A1 gene expression is thought to be regulated by several trans-acting factors including the 4S polycyclic aromatic hydrocarbon (PAH)-binding protein, which was recently identified as glycine N-methyltransferase [Raha, A., Wagner, C., MacDonald, R. G., and Bresnick, E. (1994) J. Biol. Polycyclic Aromatic Hydrocarbons 156-159 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 12-30 9245423-1 1997 In the rat, cytochrome P4501A1 gene expression is thought to be regulated by several trans-acting factors including the 4S polycyclic aromatic hydrocarbon (PAH)-binding protein, which was recently identified as glycine N-methyltransferase [Raha, A., Wagner, C., MacDonald, R. G., and Bresnick, E. (1994) J. Biol. Polycyclic Aromatic Hydrocarbons 156-159 glycine N-methyltransferase Rattus norvegicus 211-238 9224217-2 1997 PAH are converted to carcinogenic molecules through a combination of monoxygenation by cytochrome p450 (CYP) enzymes in the presence of NADPH oxidoreductase (OR) and hydrolysis by microsomal epoxide hydrolase (mEH). Polycyclic Aromatic Hydrocarbons 0-3 epoxide hydrolase 1 Homo sapiens 180-208 9224217-2 1997 PAH are converted to carcinogenic molecules through a combination of monoxygenation by cytochrome p450 (CYP) enzymes in the presence of NADPH oxidoreductase (OR) and hydrolysis by microsomal epoxide hydrolase (mEH). Polycyclic Aromatic Hydrocarbons 0-3 epoxide hydrolase 1, microsomal Mus musculus 210-213 9224217-8 1997 The inducibility of human BEC CYP1A1 gene by PAH exposure was confirmed in vitro by incubating cultured immortalized human BEC with beta-naphthoflavone and observing a > 6-fold induction of CYP1A1 after 24 h. In contrast to BEC, alveolar macrophages expressed CYP1A1 at low (30-70 molecules/10(6) beta-actin molecules) to unmeasurable levels in both smokers and nonsmokers. Polycyclic Aromatic Hydrocarbons 45-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 30-36 9224217-8 1997 The inducibility of human BEC CYP1A1 gene by PAH exposure was confirmed in vitro by incubating cultured immortalized human BEC with beta-naphthoflavone and observing a > 6-fold induction of CYP1A1 after 24 h. In contrast to BEC, alveolar macrophages expressed CYP1A1 at low (30-70 molecules/10(6) beta-actin molecules) to unmeasurable levels in both smokers and nonsmokers. Polycyclic Aromatic Hydrocarbons 45-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 193-199 9224217-8 1997 The inducibility of human BEC CYP1A1 gene by PAH exposure was confirmed in vitro by incubating cultured immortalized human BEC with beta-naphthoflavone and observing a > 6-fold induction of CYP1A1 after 24 h. In contrast to BEC, alveolar macrophages expressed CYP1A1 at low (30-70 molecules/10(6) beta-actin molecules) to unmeasurable levels in both smokers and nonsmokers. Polycyclic Aromatic Hydrocarbons 45-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 193-199 9224217-8 1997 The inducibility of human BEC CYP1A1 gene by PAH exposure was confirmed in vitro by incubating cultured immortalized human BEC with beta-naphthoflavone and observing a > 6-fold induction of CYP1A1 after 24 h. In contrast to BEC, alveolar macrophages expressed CYP1A1 at low (30-70 molecules/10(6) beta-actin molecules) to unmeasurable levels in both smokers and nonsmokers. Polycyclic Aromatic Hydrocarbons 45-48 POTE ankyrin domain family member F Homo sapiens 300-310 9206005-4 1997 In addition to these enzymes, P450 monooxygenases in some fungi were implicated in the degradation of PAHs. Polycyclic Aromatic Hydrocarbons 102-106 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 30-34 9466818-7 1998 These studies suggest that the human CYP1A2 gene may be regulated by tumor promoters in addition to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 100-132 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 37-43 9377560-1 1997 Cytochrome P4501B1 is highly active in the bioactivation of polycyclic aromatic hydrocarbons (PAHs) to mutagenic metabolites. Polycyclic Aromatic Hydrocarbons 60-92 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 0-18 9377560-1 1997 Cytochrome P4501B1 is highly active in the bioactivation of polycyclic aromatic hydrocarbons (PAHs) to mutagenic metabolites. Polycyclic Aromatic Hydrocarbons 94-98 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 0-18 9377560-4 1997 To establish the role of the aryl hydrocarbon receptor (AhR) in the induction responses to PAH and TCDD in MEFs, we measured CYP1B1 expression in primary MEFs generated from congenic C57b/6 mice that differ only at the AhR locus. Polycyclic Aromatic Hydrocarbons 91-94 aryl-hydrocarbon receptor Mus musculus 56-59 9404054-7 1997 Inter-individual variance was higher (52-fold) in persons who constitutively lack the Glutathione S-Transferase M1 (GSTM1) gene which is important in the detoxification pathway of PAH. Polycyclic Aromatic Hydrocarbons 180-183 glutathione S-transferase mu 1 Homo sapiens 86-114 9404054-7 1997 Inter-individual variance was higher (52-fold) in persons who constitutively lack the Glutathione S-Transferase M1 (GSTM1) gene which is important in the detoxification pathway of PAH. Polycyclic Aromatic Hydrocarbons 180-183 glutathione S-transferase mu 1 Homo sapiens 116-121 9299520-8 1997 The widely different activities of the allelic isoforms toward carcinogenic diol epoxides of polycyclic aromatic hydrocarbons may help to explain the correlation between cancer susceptibility and genotype at the hGSTP1 locus that has been found by others. Polycyclic Aromatic Hydrocarbons 93-125 glutathione S-transferase pi 1 Homo sapiens 212-218 8921980-12 1996 It is proposed that bacterial mutagenicity reflects the cancer initiation potency, whereas the AhR affinity reflects the promotive effect of some PAH at the high doses applied in rodent carcinogenicity tests. Polycyclic Aromatic Hydrocarbons 146-149 aryl hydrocarbon receptor Homo sapiens 95-98 9891107-12 1997 The results are consistent with the view that a slow-acetylator status and lack of the GSTM1 gene are individual risk factors for bladder cancer in persons occupationally exposed to aromatic amines and PAHs. Polycyclic Aromatic Hydrocarbons 202-206 glutathione S-transferase mu 1 Homo sapiens 87-92 9070608-1 1997 Expression in the lung of procarcinogen-metabolizing P450 enzymes in the CYP3A subfamily may contribute to the initiation of pulmonary carcinogenesis by agents that require metabolic activation, such as tobacco-derived polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 219-251 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 73-78 9013560-7 1997 The cAMP analog dibutyryl cAMP, the adenylate cyclase activator forskolin, and the protein phosphatase 1 and 2A inhibitor okadaic acid all dramatically inhibited both PAH induction and H8 potentiation of PAH induction of aldh3 expression but had no effect on induction of cyp1A1 expression in cultured hepatocytes. Polycyclic Aromatic Hydrocarbons 167-170 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 272-278 9013560-7 1997 The cAMP analog dibutyryl cAMP, the adenylate cyclase activator forskolin, and the protein phosphatase 1 and 2A inhibitor okadaic acid all dramatically inhibited both PAH induction and H8 potentiation of PAH induction of aldh3 expression but had no effect on induction of cyp1A1 expression in cultured hepatocytes. Polycyclic Aromatic Hydrocarbons 204-207 cathelicidin antimicrobial peptide Rattus norvegicus 4-8 9013560-7 1997 The cAMP analog dibutyryl cAMP, the adenylate cyclase activator forskolin, and the protein phosphatase 1 and 2A inhibitor okadaic acid all dramatically inhibited both PAH induction and H8 potentiation of PAH induction of aldh3 expression but had no effect on induction of cyp1A1 expression in cultured hepatocytes. Polycyclic Aromatic Hydrocarbons 204-207 cathelicidin antimicrobial peptide Rattus norvegicus 26-30 9067484-0 1997 Role of the aromatic hydrocarbon receptor in the suppression of cytochrome P-450 2C11 by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 89-121 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 64-85 9067484-1 1997 The aromatic hydrocarbon (AH) receptor mediates the induction of cytochromes P-450 (CYP) of the CYP1A subfamily caused by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 122-154 aryl hydrocarbon receptor Rattus norvegicus 4-38 9067484-1 1997 The aromatic hydrocarbon (AH) receptor mediates the induction of cytochromes P-450 (CYP) of the CYP1A subfamily caused by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 122-154 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 65-82 9067484-1 1997 The aromatic hydrocarbon (AH) receptor mediates the induction of cytochromes P-450 (CYP) of the CYP1A subfamily caused by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 122-154 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 84-87 9067484-1 1997 The aromatic hydrocarbon (AH) receptor mediates the induction of cytochromes P-450 (CYP) of the CYP1A subfamily caused by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 156-160 aryl hydrocarbon receptor Rattus norvegicus 4-38 9067484-1 1997 The aromatic hydrocarbon (AH) receptor mediates the induction of cytochromes P-450 (CYP) of the CYP1A subfamily caused by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 156-160 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 65-82 9067484-1 1997 The aromatic hydrocarbon (AH) receptor mediates the induction of cytochromes P-450 (CYP) of the CYP1A subfamily caused by polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 156-160 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 84-87 9067484-3 1997 We performed a structure-activity relationship study with a series of PAHs of the anthracene class in order to determine if the AH receptor is involved in CYP2C11 down-regulation. Polycyclic Aromatic Hydrocarbons 70-74 aryl hydrocarbon receptor Rattus norvegicus 128-139 9054627-7 1997 Yet the individuals lacking GSTM1 had a stronger effect of LOGU1OH and some effect by other sources of PAH, such as charcoal broiled food, although all these variables were not significant in the multivariate model. Polycyclic Aromatic Hydrocarbons 103-106 glutathione S-transferase mu 1 Homo sapiens 28-33 9070347-3 1997 DEP contain a wide spectrum of polycyclic aromatic hydrocarbons (PAH) that have been reported to have direct effects on the immune system, including the modulation of IgE production using various human and murine cell populations. Polycyclic Aromatic Hydrocarbons 31-63 immunoglobulin heavy constant epsilon Homo sapiens 167-170 9070347-3 1997 DEP contain a wide spectrum of polycyclic aromatic hydrocarbons (PAH) that have been reported to have direct effects on the immune system, including the modulation of IgE production using various human and murine cell populations. Polycyclic Aromatic Hydrocarbons 65-68 immunoglobulin heavy constant epsilon Homo sapiens 167-170 9070347-4 1997 We investigated the effects of the organic extract of DEP (PAH-DEP) and particularly, phenanthrene, a major component of DEP, in vitro on IgE production by 2C4/F3, a human Epstein-Barr virus transformed isotype switched, IgE producing B cell line. Polycyclic Aromatic Hydrocarbons 59-62 immunoglobulin heavy constant epsilon Homo sapiens 138-141 9070358-12 1997 The results of this study support the use of tissue-specific patterns of CYP1A expression in identification of target sites and exposure routes for polycyclic aromatic hydrocarbons and other compounds. Polycyclic Aromatic Hydrocarbons 148-180 cytochrome P450 1A1 Fundulus heteroclitus 73-78 9013560-3 1997 As was seen for the cytochrome P450 (cyp1A1) gene, aldh3 is transcriptionally inducible by polycyclic aromatic hydrocarbons (PAH), and this induction involving function of the arylhydrocarbon (Ah) receptor is inhibited by the protein kinase C (PKC) inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine di-HCl (H7) and staurosporine. Polycyclic Aromatic Hydrocarbons 91-123 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 20-43 9013560-3 1997 As was seen for the cytochrome P450 (cyp1A1) gene, aldh3 is transcriptionally inducible by polycyclic aromatic hydrocarbons (PAH), and this induction involving function of the arylhydrocarbon (Ah) receptor is inhibited by the protein kinase C (PKC) inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine di-HCl (H7) and staurosporine. Polycyclic Aromatic Hydrocarbons 91-123 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 51-56 9013560-3 1997 As was seen for the cytochrome P450 (cyp1A1) gene, aldh3 is transcriptionally inducible by polycyclic aromatic hydrocarbons (PAH), and this induction involving function of the arylhydrocarbon (Ah) receptor is inhibited by the protein kinase C (PKC) inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine di-HCl (H7) and staurosporine. Polycyclic Aromatic Hydrocarbons 125-128 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 20-43 9013560-3 1997 As was seen for the cytochrome P450 (cyp1A1) gene, aldh3 is transcriptionally inducible by polycyclic aromatic hydrocarbons (PAH), and this induction involving function of the arylhydrocarbon (Ah) receptor is inhibited by the protein kinase C (PKC) inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine di-HCl (H7) and staurosporine. Polycyclic Aromatic Hydrocarbons 125-128 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 51-56 9013560-4 1997 However, PAH induction of ALDH-3 activity, protein, and mRNA was potentiated 2-4-fold by addition of the protein kinase A (PKA) inhibitors, N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide di-HCl (H8) and N-(2-guanidinoethyl)-5-isoquinolinesulfonamide HCl (HA1004). Polycyclic Aromatic Hydrocarbons 9-12 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 26-32 9013560-4 1997 However, PAH induction of ALDH-3 activity, protein, and mRNA was potentiated 2-4-fold by addition of the protein kinase A (PKA) inhibitors, N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide di-HCl (H8) and N-(2-guanidinoethyl)-5-isoquinolinesulfonamide HCl (HA1004). Polycyclic Aromatic Hydrocarbons 9-12 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 105-121 9013560-4 1997 However, PAH induction of ALDH-3 activity, protein, and mRNA was potentiated 2-4-fold by addition of the protein kinase A (PKA) inhibitors, N-(2-(methylamino)ethyl)-5-isoquinolinesulfonamide di-HCl (H8) and N-(2-guanidinoethyl)-5-isoquinolinesulfonamide HCl (HA1004). Polycyclic Aromatic Hydrocarbons 9-12 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 123-126 9013560-6 1997 Protein kinase A activity of cultured hepatocytes was specifically inhibited by H8 and HA1004 in a concentration-dependent manner, but not by H7, and there was an inverse correlation observed between potentiation of PAH-induced aldh3 gene expression and inhibition of specific PKA activity by the PKA inhibitors. Polycyclic Aromatic Hydrocarbons 216-219 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 0-16 9013560-6 1997 Protein kinase A activity of cultured hepatocytes was specifically inhibited by H8 and HA1004 in a concentration-dependent manner, but not by H7, and there was an inverse correlation observed between potentiation of PAH-induced aldh3 gene expression and inhibition of specific PKA activity by the PKA inhibitors. Polycyclic Aromatic Hydrocarbons 216-219 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 228-233 9013560-6 1997 Protein kinase A activity of cultured hepatocytes was specifically inhibited by H8 and HA1004 in a concentration-dependent manner, but not by H7, and there was an inverse correlation observed between potentiation of PAH-induced aldh3 gene expression and inhibition of specific PKA activity by the PKA inhibitors. Polycyclic Aromatic Hydrocarbons 216-219 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 277-280 9013560-6 1997 Protein kinase A activity of cultured hepatocytes was specifically inhibited by H8 and HA1004 in a concentration-dependent manner, but not by H7, and there was an inverse correlation observed between potentiation of PAH-induced aldh3 gene expression and inhibition of specific PKA activity by the PKA inhibitors. Polycyclic Aromatic Hydrocarbons 216-219 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 297-300 9013560-7 1997 The cAMP analog dibutyryl cAMP, the adenylate cyclase activator forskolin, and the protein phosphatase 1 and 2A inhibitor okadaic acid all dramatically inhibited both PAH induction and H8 potentiation of PAH induction of aldh3 expression but had no effect on induction of cyp1A1 expression in cultured hepatocytes. Polycyclic Aromatic Hydrocarbons 167-170 cathelicidin antimicrobial peptide Rattus norvegicus 4-8 9013560-7 1997 The cAMP analog dibutyryl cAMP, the adenylate cyclase activator forskolin, and the protein phosphatase 1 and 2A inhibitor okadaic acid all dramatically inhibited both PAH induction and H8 potentiation of PAH induction of aldh3 expression but had no effect on induction of cyp1A1 expression in cultured hepatocytes. Polycyclic Aromatic Hydrocarbons 167-170 cathelicidin antimicrobial peptide Rattus norvegicus 26-30 9013560-7 1997 The cAMP analog dibutyryl cAMP, the adenylate cyclase activator forskolin, and the protein phosphatase 1 and 2A inhibitor okadaic acid all dramatically inhibited both PAH induction and H8 potentiation of PAH induction of aldh3 expression but had no effect on induction of cyp1A1 expression in cultured hepatocytes. Polycyclic Aromatic Hydrocarbons 167-170 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 221-226 9054596-2 1997 BPD UGT activity is induced in female F344 rat liver by treatment with the selective Phase 2 conjugation enzyme inducer oltipraz [4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione at 75-450 mg/kg per day for 3 days] and also by a polycyclic aromatic hydrocarbon-type inducer, beta-naphthoflavone (80 mg/kg per day for 3 days). Polycyclic Aromatic Hydrocarbons 227-258 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 4-7 9010625-1 1997 The predominant inducible cytochrome P450 (CYP) in rat small intestine is CYP1A1, which, when induced to elevated levels by xenobiotics or dietary constituents, has the potential to metabolize and consequently reduce the systemic uptake of low concentrations of orally ingested, bioactivatable polycyclic aromatic hydrocarbons and heterocyclic aromatic amines. Polycyclic Aromatic Hydrocarbons 294-326 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 74-80 8970185-4 1997 Because genetic polymorphism of cytochrome P-4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) has been associated with interference in formation of reactive intermediates and detoxification of polycyclic aromatic hydrocarbons, we also obtained data concerning genetic polymorphism of CYP1A1 and GSTM1. Polycyclic Aromatic Hydrocarbons 201-233 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-51 8970185-4 1997 Because genetic polymorphism of cytochrome P-4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) has been associated with interference in formation of reactive intermediates and detoxification of polycyclic aromatic hydrocarbons, we also obtained data concerning genetic polymorphism of CYP1A1 and GSTM1. Polycyclic Aromatic Hydrocarbons 201-233 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 8970185-4 1997 Because genetic polymorphism of cytochrome P-4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) has been associated with interference in formation of reactive intermediates and detoxification of polycyclic aromatic hydrocarbons, we also obtained data concerning genetic polymorphism of CYP1A1 and GSTM1. Polycyclic Aromatic Hydrocarbons 201-233 glutathione S-transferase mu 1 Homo sapiens 65-93 8970185-4 1997 Because genetic polymorphism of cytochrome P-4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) has been associated with interference in formation of reactive intermediates and detoxification of polycyclic aromatic hydrocarbons, we also obtained data concerning genetic polymorphism of CYP1A1 and GSTM1. Polycyclic Aromatic Hydrocarbons 201-233 glutathione S-transferase mu 1 Homo sapiens 95-100 8970185-4 1997 Because genetic polymorphism of cytochrome P-4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) has been associated with interference in formation of reactive intermediates and detoxification of polycyclic aromatic hydrocarbons, we also obtained data concerning genetic polymorphism of CYP1A1 and GSTM1. Polycyclic Aromatic Hydrocarbons 201-233 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 292-298 8970185-4 1997 Because genetic polymorphism of cytochrome P-4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) has been associated with interference in formation of reactive intermediates and detoxification of polycyclic aromatic hydrocarbons, we also obtained data concerning genetic polymorphism of CYP1A1 and GSTM1. Polycyclic Aromatic Hydrocarbons 201-233 glutathione S-transferase mu 1 Homo sapiens 303-308 8955080-1 1996 In the rat, cytochrome P4501A1 gene expression is thought to be regulated by several trans-acting factors including the 4 S polycyclic aromatic hydrocarbon (PAH)-binding protein. Polycyclic Aromatic Hydrocarbons 124-155 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 12-30 8955080-1 1996 In the rat, cytochrome P4501A1 gene expression is thought to be regulated by several trans-acting factors including the 4 S polycyclic aromatic hydrocarbon (PAH)-binding protein. Polycyclic Aromatic Hydrocarbons 157-160 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 12-30 8954573-0 1996 Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1A1: a CO flash photolysis study. Polycyclic Aromatic Hydrocarbons 15-47 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 59-78 8954573-1 1996 The kinetics of CO binding to human cytochrome P450 1A1 was used to probe the interaction of polycyclic aromatic hydrocarbons (PAHs) with the membrane-bound P450 expressed in baculovirus-infected SF9 insect cells. Polycyclic Aromatic Hydrocarbons 93-125 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-55 8954573-1 1996 The kinetics of CO binding to human cytochrome P450 1A1 was used to probe the interaction of polycyclic aromatic hydrocarbons (PAHs) with the membrane-bound P450 expressed in baculovirus-infected SF9 insect cells. Polycyclic Aromatic Hydrocarbons 93-125 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 47-51 8954573-1 1996 The kinetics of CO binding to human cytochrome P450 1A1 was used to probe the interaction of polycyclic aromatic hydrocarbons (PAHs) with the membrane-bound P450 expressed in baculovirus-infected SF9 insect cells. Polycyclic Aromatic Hydrocarbons 127-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-55 8954573-1 1996 The kinetics of CO binding to human cytochrome P450 1A1 was used to probe the interaction of polycyclic aromatic hydrocarbons (PAHs) with the membrane-bound P450 expressed in baculovirus-infected SF9 insect cells. Polycyclic Aromatic Hydrocarbons 127-131 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 47-51 8954573-11 1996 The markedly variable effects of these PAHs and resorufins on the CO binding kinetics indicate differential modes of interaction with the two target P450 1A1 species, resulting in differential modulation of their conformations. Polycyclic Aromatic Hydrocarbons 39-43 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 149-153 8954090-0 1996 The anti-estrogenic activity of selected polynuclear aromatic hydrocarbons in yeast expressing human estrogen receptor. Polycyclic Aromatic Hydrocarbons 41-74 estrogen receptor 1 Homo sapiens 101-118 8885846-2 1996 A novel pathway of polycyclic aromatic hydrocarbon metabolism involves the oxidation of non-K-region trans-dihydrodiols to yield o-quinones, a reaction catalyzed by dihydrodiol dehydrogenase (DD). Polycyclic Aromatic Hydrocarbons 19-50 dihydrodiol dehydrogenase Rattus norvegicus 165-190 8824276-1 1996 Transcriptional activation of the human CYP1A1 gene by halogenated and polycyclic aromatic hydrocarbons is mediated by the aryl hydrocarbon receptor (AhR) complex, a ligand-dependent transcription factor. Polycyclic Aromatic Hydrocarbons 71-103 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 40-46 8824276-1 1996 Transcriptional activation of the human CYP1A1 gene by halogenated and polycyclic aromatic hydrocarbons is mediated by the aryl hydrocarbon receptor (AhR) complex, a ligand-dependent transcription factor. Polycyclic Aromatic Hydrocarbons 71-103 aryl hydrocarbon receptor Homo sapiens 123-148 8824276-1 1996 Transcriptional activation of the human CYP1A1 gene by halogenated and polycyclic aromatic hydrocarbons is mediated by the aryl hydrocarbon receptor (AhR) complex, a ligand-dependent transcription factor. Polycyclic Aromatic Hydrocarbons 71-103 aryl hydrocarbon receptor Homo sapiens 150-153 8870659-1 1996 Diol epoxides formed by the sequential action of cytochrome P-450 and the microsomal epoxide hydrolase (mEH) in the endoplasmic reticulum (ER) represent an important class of ultimate carcinogenic metabolites of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 212-244 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 49-65 8870659-1 1996 Diol epoxides formed by the sequential action of cytochrome P-450 and the microsomal epoxide hydrolase (mEH) in the endoplasmic reticulum (ER) represent an important class of ultimate carcinogenic metabolites of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 212-244 epoxide hydrolase 1 Rattus norvegicus 74-102 8870659-1 1996 Diol epoxides formed by the sequential action of cytochrome P-450 and the microsomal epoxide hydrolase (mEH) in the endoplasmic reticulum (ER) represent an important class of ultimate carcinogenic metabolites of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 212-244 epoxide hydrolase 1, microsomal Mus musculus 104-107 8903507-6 1996 Using cultured rat hepatocytes, we have demonstrated that polycyclic aromatic hydrocarbon (PAH) induction of cytochrome P4501A1, glutathione S-transferase Ya1, and UDP-glucuronosyltransferase 1*6 are apparently potentiated two- to fourfold upon inclusion of glucocorticoids in the media to activate the glucocorticoid receptor and further, that the receptor antagonist RU 38486 reverses these phenomenon. Polycyclic Aromatic Hydrocarbons 58-89 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 109-127 8999837-1 1997 Previous work has shown that polycyclic aromatic hydrocarbons and oltipraz both induce an unidentified rat liver UDP-glucuronosyltransferase with activity toward benzo(a)pyrene-7, 8-diol, the proximate carcinogenic form of benzo(a)pyrene. Polycyclic Aromatic Hydrocarbons 29-61 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 113-140 8903507-6 1996 Using cultured rat hepatocytes, we have demonstrated that polycyclic aromatic hydrocarbon (PAH) induction of cytochrome P4501A1, glutathione S-transferase Ya1, and UDP-glucuronosyltransferase 1*6 are apparently potentiated two- to fourfold upon inclusion of glucocorticoids in the media to activate the glucocorticoid receptor and further, that the receptor antagonist RU 38486 reverses these phenomenon. Polycyclic Aromatic Hydrocarbons 58-89 glutathione S-transferase alpha 2 Rattus norvegicus 129-158 8903507-6 1996 Using cultured rat hepatocytes, we have demonstrated that polycyclic aromatic hydrocarbon (PAH) induction of cytochrome P4501A1, glutathione S-transferase Ya1, and UDP-glucuronosyltransferase 1*6 are apparently potentiated two- to fourfold upon inclusion of glucocorticoids in the media to activate the glucocorticoid receptor and further, that the receptor antagonist RU 38486 reverses these phenomenon. Polycyclic Aromatic Hydrocarbons 58-89 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 164-195 8903507-6 1996 Using cultured rat hepatocytes, we have demonstrated that polycyclic aromatic hydrocarbon (PAH) induction of cytochrome P4501A1, glutathione S-transferase Ya1, and UDP-glucuronosyltransferase 1*6 are apparently potentiated two- to fourfold upon inclusion of glucocorticoids in the media to activate the glucocorticoid receptor and further, that the receptor antagonist RU 38486 reverses these phenomenon. Polycyclic Aromatic Hydrocarbons 58-89 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 303-326 8903507-6 1996 Using cultured rat hepatocytes, we have demonstrated that polycyclic aromatic hydrocarbon (PAH) induction of cytochrome P4501A1, glutathione S-transferase Ya1, and UDP-glucuronosyltransferase 1*6 are apparently potentiated two- to fourfold upon inclusion of glucocorticoids in the media to activate the glucocorticoid receptor and further, that the receptor antagonist RU 38486 reverses these phenomenon. Polycyclic Aromatic Hydrocarbons 91-94 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 109-127 8903507-6 1996 Using cultured rat hepatocytes, we have demonstrated that polycyclic aromatic hydrocarbon (PAH) induction of cytochrome P4501A1, glutathione S-transferase Ya1, and UDP-glucuronosyltransferase 1*6 are apparently potentiated two- to fourfold upon inclusion of glucocorticoids in the media to activate the glucocorticoid receptor and further, that the receptor antagonist RU 38486 reverses these phenomenon. Polycyclic Aromatic Hydrocarbons 91-94 glutathione S-transferase alpha 2 Rattus norvegicus 129-158 8903507-6 1996 Using cultured rat hepatocytes, we have demonstrated that polycyclic aromatic hydrocarbon (PAH) induction of cytochrome P4501A1, glutathione S-transferase Ya1, and UDP-glucuronosyltransferase 1*6 are apparently potentiated two- to fourfold upon inclusion of glucocorticoids in the media to activate the glucocorticoid receptor and further, that the receptor antagonist RU 38486 reverses these phenomenon. Polycyclic Aromatic Hydrocarbons 91-94 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 164-195 8903507-6 1996 Using cultured rat hepatocytes, we have demonstrated that polycyclic aromatic hydrocarbon (PAH) induction of cytochrome P4501A1, glutathione S-transferase Ya1, and UDP-glucuronosyltransferase 1*6 are apparently potentiated two- to fourfold upon inclusion of glucocorticoids in the media to activate the glucocorticoid receptor and further, that the receptor antagonist RU 38486 reverses these phenomenon. Polycyclic Aromatic Hydrocarbons 91-94 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 303-326 8903507-8 1996 The effect of glucocorticoid concentration on PAH induction of glutathione S-transferase Ya1 subunit for glucocorticoids was biphasic, but at physiological concentrations gene expression was repressed to approximately 20-40% of control. Polycyclic Aromatic Hydrocarbons 46-49 glutathione S-transferase alpha 2 Rattus norvegicus 63-92 8798449-8 1996 Thus, the loss of polycyclic aromatic hydrocarbon sensitivity in high passage rat epidermal cells appears to be due to decreased expression of CYP1A1, and this effect may be mediated by an altered NeRD binding factor(s) present in these cells. Polycyclic Aromatic Hydrocarbons 18-49 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 143-149 8810903-8 1996 (2) This unique molecular structure can explain why GNMT can capture folate and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 80-112 glycine N-methyltransferase Rattus norvegicus 52-56 8810903-10 1996 From the structural features of GNMT, we propose that the enzyme might be able to capture yet unidentified molecules in the cytosol and thus participates in various biological processes including detoxification of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 214-246 glycine N-methyltransferase Rattus norvegicus 32-36 8870993-8 1996 Binding affinities to selected PAH, BP-DNA adducts, and BP metabolites indicate significant contributions of the hydrophobic region C-3, C-4, and C-5 of BP and the polar oxygen of guanine to MAb/adduct binding. Polycyclic Aromatic Hydrocarbons 31-34 complement C3 Homo sapiens 132-135 8844979-1 1996 The bioactivation of N-nitrosoamines and polycyclic aromatic hydrocarbons (PAH) is mediated by the mixed function oxidase system, which includes dimethylnitrosamine N-demethylase I (DMN-dI), arylhydrocarbon hydroxylase (AHH), cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase of liver microsomes. Polycyclic Aromatic Hydrocarbons 41-73 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 191-218 8844979-1 1996 The bioactivation of N-nitrosoamines and polycyclic aromatic hydrocarbons (PAH) is mediated by the mixed function oxidase system, which includes dimethylnitrosamine N-demethylase I (DMN-dI), arylhydrocarbon hydroxylase (AHH), cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase of liver microsomes. Polycyclic Aromatic Hydrocarbons 41-73 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 220-223 8844979-1 1996 The bioactivation of N-nitrosoamines and polycyclic aromatic hydrocarbons (PAH) is mediated by the mixed function oxidase system, which includes dimethylnitrosamine N-demethylase I (DMN-dI), arylhydrocarbon hydroxylase (AHH), cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase of liver microsomes. Polycyclic Aromatic Hydrocarbons 41-73 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 226-257 8844979-1 1996 The bioactivation of N-nitrosoamines and polycyclic aromatic hydrocarbons (PAH) is mediated by the mixed function oxidase system, which includes dimethylnitrosamine N-demethylase I (DMN-dI), arylhydrocarbon hydroxylase (AHH), cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase of liver microsomes. Polycyclic Aromatic Hydrocarbons 75-78 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 191-218 8844979-1 1996 The bioactivation of N-nitrosoamines and polycyclic aromatic hydrocarbons (PAH) is mediated by the mixed function oxidase system, which includes dimethylnitrosamine N-demethylase I (DMN-dI), arylhydrocarbon hydroxylase (AHH), cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase of liver microsomes. Polycyclic Aromatic Hydrocarbons 75-78 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 220-223 8844979-1 1996 The bioactivation of N-nitrosoamines and polycyclic aromatic hydrocarbons (PAH) is mediated by the mixed function oxidase system, which includes dimethylnitrosamine N-demethylase I (DMN-dI), arylhydrocarbon hydroxylase (AHH), cytochrome P-450, cytochrome b5 and NADPH-cytochrome c reductase of liver microsomes. Polycyclic Aromatic Hydrocarbons 75-78 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 226-257 8870993-8 1996 Binding affinities to selected PAH, BP-DNA adducts, and BP metabolites indicate significant contributions of the hydrophobic region C-3, C-4, and C-5 of BP and the polar oxygen of guanine to MAb/adduct binding. Polycyclic Aromatic Hydrocarbons 31-34 complement C4A (Rodgers blood group) Homo sapiens 137-140 8870993-8 1996 Binding affinities to selected PAH, BP-DNA adducts, and BP metabolites indicate significant contributions of the hydrophobic region C-3, C-4, and C-5 of BP and the polar oxygen of guanine to MAb/adduct binding. Polycyclic Aromatic Hydrocarbons 31-34 complement C5 Homo sapiens 146-149 8761425-7 1996 Our results suggest that smoking coke oven workers with genotypes unfavourable for detoxification of aromatic amines (NAT2-ss) and PAH (GSTM1-null) may have an increased risk of developing bladder cancer. Polycyclic Aromatic Hydrocarbons 131-134 glutathione S-transferase mu 1 Homo sapiens 136-141 8806728-1 1996 Polycyclic aromatic hydrocarbons, such as benzo(a)pyrene (BaP), have been implicated in the initiation and progression of vascular lesions of atherosclerotic morphology in laboratory animals. Polycyclic Aromatic Hydrocarbons 0-32 prohibitin 2 Rattus norvegicus 58-61 8823236-2 1996 This study investigated the relationship between fluvoxamine disposition and the polymorphic CYP2D6 and the polycyclic aromatic hydrocarbon (as contained in cigarette smoke) inducible CYP1A2. Polycyclic Aromatic Hydrocarbons 108-139 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 184-190 8706258-1 1996 A pharmacogenetic mouse model was utilized to determine the role of Cyp1a1 expression on the formation of Ki-ras mutations in lung tumors following transplacental exposure to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 175-207 Kirsten rat sarcoma viral oncogene homolog Mus musculus 106-112 8806850-5 1996 Our results using human lymphocytes differed from previous studies in rodents, in that BaP and 3-MC were the most immunotoxic PAHs in the human mitogenesis assay, while DMBA has long been regarded as the PAH that is most potently toxic to rodent T cell responses. Polycyclic Aromatic Hydrocarbons 126-130 prohibitin 2 Homo sapiens 87-90 8806850-5 1996 Our results using human lymphocytes differed from previous studies in rodents, in that BaP and 3-MC were the most immunotoxic PAHs in the human mitogenesis assay, while DMBA has long been regarded as the PAH that is most potently toxic to rodent T cell responses. Polycyclic Aromatic Hydrocarbons 126-129 prohibitin 2 Homo sapiens 87-90 8692233-11 1996 We found a weak association between total PAH-DNA adduct levels in lung tissue and TP53 mutations. Polycyclic Aromatic Hydrocarbons 42-45 tumor protein p53 Homo sapiens 83-87 8706258-1 1996 A pharmacogenetic mouse model was utilized to determine the role of Cyp1a1 expression on the formation of Ki-ras mutations in lung tumors following transplacental exposure to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 209-213 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 68-74 8685897-8 1996 These findings encourage consideration of AhR- independent events in PAH risk assessment. Polycyclic Aromatic Hydrocarbons 69-72 aryl-hydrocarbon receptor Mus musculus 42-45 8630083-1 1996 Expression of P-glycoprotein (P-gp), a plasma membrane glycoprotein involved in multidrug resistance and encoded by mdr genes, was investigated in nonparenchymal rat liver epithelial (RLE) cells in response to acute exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 241-273 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 14-28 8630083-1 1996 Expression of P-glycoprotein (P-gp), a plasma membrane glycoprotein involved in multidrug resistance and encoded by mdr genes, was investigated in nonparenchymal rat liver epithelial (RLE) cells in response to acute exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 241-273 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 30-34 8630083-1 1996 Expression of P-glycoprotein (P-gp), a plasma membrane glycoprotein involved in multidrug resistance and encoded by mdr genes, was investigated in nonparenchymal rat liver epithelial (RLE) cells in response to acute exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 275-279 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 14-28 8630083-1 1996 Expression of P-glycoprotein (P-gp), a plasma membrane glycoprotein involved in multidrug resistance and encoded by mdr genes, was investigated in nonparenchymal rat liver epithelial (RLE) cells in response to acute exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 275-279 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 30-34 8860004-5 1996 Because of the importance of the CYP1A1 gene (which encodes the aromatic hydrocarbon hydroxylase) as a biomarker of genetic susceptibility to environmental carcinogens such as polycyclic aromatic hydrocarbons, these data may provide a useful reference for future studies of relationships between CYP1A1 genotype and disease susceptibility. Polycyclic Aromatic Hydrocarbons 176-208 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 33-39 8666157-1 1996 The induction of microsomal cytochrome P4501A1 by polycyclic aromatic hydrocarbons represents an interesting response by which mammalian cells adapt to xenobiotic exposure. Polycyclic Aromatic Hydrocarbons 50-82 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 28-46 8860004-5 1996 Because of the importance of the CYP1A1 gene (which encodes the aromatic hydrocarbon hydroxylase) as a biomarker of genetic susceptibility to environmental carcinogens such as polycyclic aromatic hydrocarbons, these data may provide a useful reference for future studies of relationships between CYP1A1 genotype and disease susceptibility. Polycyclic Aromatic Hydrocarbons 176-208 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 296-302 8638931-8 1996 Since human 1A1, a predominant enzyme for metabolism of polycyclic aromatic hydrocarbons, is not significantly expressed in the liver, hepatic microsomal 2C9, 1A2, and 2B6 all probably contribute to the metabolic activation of DB[a,h]A. Polycyclic Aromatic Hydrocarbons 56-88 solute carrier family 45 member 2 Homo sapiens 12-15 8571376-15 1995 We conclude from the DNA adduct and Ki-ras mutation studies that bay region diol-epoxide-2"-deoxyguanosine PAH-DNA adducts are associated with the GGT-->TGT mutations, and cyclopenta-ring oxide-2"-deoxyguanosine adducts associated with the GGT-->CGT mutations. Polycyclic Aromatic Hydrocarbons 107-110 Kirsten rat sarcoma viral oncogene homolog Mus musculus 36-42 8620579-1 1996 Eight polycyclic aromatic hydrocarbon (PAH) ortho-quinones that can be generated by dihydrodiol dehydrogenase (DD) were examined for their cytotoxicity in H-4-II-e (rat hepatoma) cells and for their mutagenicity in the Ames test. Polycyclic Aromatic Hydrocarbons 6-37 dihydrodiol dehydrogenase Rattus norvegicus 84-109 8620579-1 1996 Eight polycyclic aromatic hydrocarbon (PAH) ortho-quinones that can be generated by dihydrodiol dehydrogenase (DD) were examined for their cytotoxicity in H-4-II-e (rat hepatoma) cells and for their mutagenicity in the Ames test. Polycyclic Aromatic Hydrocarbons 39-42 dihydrodiol dehydrogenase Rattus norvegicus 84-109 8579379-2 1996 The extent of cytochrome P450IA1 (CYP1A1) induction in the liver correlated with the amount of 5- and 6-ring PAHs in the soil samples but not with the total PAH content. Polycyclic Aromatic Hydrocarbons 109-112 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 34-40 8579379-4 1996 The highest induction of CYP1A1 was obtained with a sample containing 274 mg 5- and 6-ring PAH/kg soil, resulting in a nearly 360-fold increase in the ethoxyresorufin deethylase (EROD) activity. Polycyclic Aromatic Hydrocarbons 91-94 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 25-31 8579379-5 1996 In a semilogarithmic plot, a linear correlation was found between the 5- and 6-ring PAH concentration in the soil and the microsomal CYP1A1 content. Polycyclic Aromatic Hydrocarbons 84-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 133-139 8597484-10 1995 Hydroxymethyl PAHs are sulfated and bioactivated at a relatively rapid rate by DHEA-ST, whereas 1"-hydroxysafrole and N-hydroxy-2-acetylaminofluorene are bioactivated to a lesser extent. Polycyclic Aromatic Hydrocarbons 14-18 sulfotransferase family 2A member 1 Homo sapiens 79-86 8631128-1 1996 Cytochrome CYP1A1 gene expression, induced by polycyclic aromatic hydrocarbons and dioxins, eg. Polycyclic Aromatic Hydrocarbons 46-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 11-17 24203299-0 1996 Characterization of flame-generated C10 to C 160 polycyclic aromatic hydrocarbons by atmospheric-pressure chemical ionization mass spectrometry with liquid introduction via heated nebulizer interface. Polycyclic Aromatic Hydrocarbons 49-81 homeobox C10 Homo sapiens 36-39 8729008-2 1996 One of these hemoproteins, cytochrome P4501A1, is most closely associated with the bioactivation of polycyclic aromatic hydrocarbons such as benzo[a]pyrene, which may play a role in environmental carcinogenesis. Polycyclic Aromatic Hydrocarbons 100-132 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 27-45 8571376-15 1995 We conclude from the DNA adduct and Ki-ras mutation studies that bay region diol-epoxide-2"-deoxyguanosine PAH-DNA adducts are associated with the GGT-->TGT mutations, and cyclopenta-ring oxide-2"-deoxyguanosine adducts associated with the GGT-->CGT mutations. Polycyclic Aromatic Hydrocarbons 107-110 queuine tRNA-ribosyltransferase catalytic subunit 1 Mus musculus 156-159 8571376-15 1995 We conclude from the DNA adduct and Ki-ras mutation studies that bay region diol-epoxide-2"-deoxyguanosine PAH-DNA adducts are associated with the GGT-->TGT mutations, and cyclopenta-ring oxide-2"-deoxyguanosine adducts associated with the GGT-->CGT mutations. Polycyclic Aromatic Hydrocarbons 107-110 UDP galactosyltransferase 8A Mus musculus 252-255 8830563-5 1995 Two enzymes of cytochrome P450, CYP1A1 and CYP1A2, are inducible by tobacco carcinogens, and animal studies evidenced a genetic polymorphism of CYP1A1 associated with tumour occurrence after administration of a polycyclic aromatic hydrocarbon. Polycyclic Aromatic Hydrocarbons 211-242 uncharacterized protein LOC107819388 Nicotiana tabacum 15-38 8674863-0 1995 Cytochromes CYP1A1 and CYP1B1 in the rat mammary gland: cell-specific expression and regulation by polycyclic aromatic hydrocarbons and hormones. Polycyclic Aromatic Hydrocarbons 99-131 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 12-18 8674863-0 1995 Cytochromes CYP1A1 and CYP1B1 in the rat mammary gland: cell-specific expression and regulation by polycyclic aromatic hydrocarbons and hormones. Polycyclic Aromatic Hydrocarbons 99-131 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 23-29 8674863-1 1995 Cultured rat mammary cells express both CYP1A1 and CYP1B1 in response to polycyclic aromatic hydrocarbons (PAH) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a cell type-specific manner. Polycyclic Aromatic Hydrocarbons 73-105 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 40-46 8674863-1 1995 Cultured rat mammary cells express both CYP1A1 and CYP1B1 in response to polycyclic aromatic hydrocarbons (PAH) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a cell type-specific manner. Polycyclic Aromatic Hydrocarbons 73-105 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 51-57 8674863-1 1995 Cultured rat mammary cells express both CYP1A1 and CYP1B1 in response to polycyclic aromatic hydrocarbons (PAH) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a cell type-specific manner. Polycyclic Aromatic Hydrocarbons 107-110 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 40-46 8674863-1 1995 Cultured rat mammary cells express both CYP1A1 and CYP1B1 in response to polycyclic aromatic hydrocarbons (PAH) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in a cell type-specific manner. Polycyclic Aromatic Hydrocarbons 107-110 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 51-57 7586163-5 1995 The results in Salmonella are consistent with a role for the PAH component of cigarette smoke in the base-substitution specificity found in the p53 gene of smoking-associated lung tumors. Polycyclic Aromatic Hydrocarbons 61-64 tumor protein p53 Homo sapiens 144-147 7546226-1 1995 Carcinogenic polycyclic aromatic hydrocarbons (PAHs) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450 (CYP) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s-transferase M1 (GSTM1). Polycyclic Aromatic Hydrocarbons 13-45 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 127-152 7546226-1 1995 Carcinogenic polycyclic aromatic hydrocarbons (PAHs) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450 (CYP) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s-transferase M1 (GSTM1). Polycyclic Aromatic Hydrocarbons 13-45 glutathione S-transferase mu 1 Homo sapiens 247-275 7546226-1 1995 Carcinogenic polycyclic aromatic hydrocarbons (PAHs) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450 (CYP) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s-transferase M1 (GSTM1). Polycyclic Aromatic Hydrocarbons 13-45 glutathione S-transferase mu 1 Homo sapiens 277-282 7546226-1 1995 Carcinogenic polycyclic aromatic hydrocarbons (PAHs) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450 (CYP) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s-transferase M1 (GSTM1). Polycyclic Aromatic Hydrocarbons 47-51 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 127-152 7546226-1 1995 Carcinogenic polycyclic aromatic hydrocarbons (PAHs) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450 (CYP) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s-transferase M1 (GSTM1). Polycyclic Aromatic Hydrocarbons 47-51 glutathione S-transferase mu 1 Homo sapiens 247-275 7546226-1 1995 Carcinogenic polycyclic aromatic hydrocarbons (PAHs) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450 (CYP) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s-transferase M1 (GSTM1). Polycyclic Aromatic Hydrocarbons 47-51 glutathione S-transferase mu 1 Homo sapiens 277-282 7546226-4 1995 In the investigation reported here, which was performed in the same population, we measured the association between the GSTM1 null genotype, which results in loss of enzyme activity, and PAH-DNA adduct levels, hypothesizing that subjects with this genotype would have higher levels of DNA adducts because of their decreased ability to detoxify PAH metabolites. Polycyclic Aromatic Hydrocarbons 187-190 glutathione S-transferase mu 1 Homo sapiens 120-125 7546226-4 1995 In the investigation reported here, which was performed in the same population, we measured the association between the GSTM1 null genotype, which results in loss of enzyme activity, and PAH-DNA adduct levels, hypothesizing that subjects with this genotype would have higher levels of DNA adducts because of their decreased ability to detoxify PAH metabolites. Polycyclic Aromatic Hydrocarbons 344-347 glutathione S-transferase mu 1 Homo sapiens 120-125 7550799-3 1995 Measurement of PAH metabolites in human urine provides a means of assessing individual internal dose of PAHs. Polycyclic Aromatic Hydrocarbons 104-108 phenylalanine hydroxylase Homo sapiens 15-18 7627950-1 1995 Polycyclic aromatic hydrocarbons, possible human breast carcinogens, are metabolized by cytochrome P4501A1 (CYP1A1) and glutathione S-transferase (GSTM1). Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 88-106 7627950-1 1995 Polycyclic aromatic hydrocarbons, possible human breast carcinogens, are metabolized by cytochrome P4501A1 (CYP1A1) and glutathione S-transferase (GSTM1). Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 108-114 7627950-1 1995 Polycyclic aromatic hydrocarbons, possible human breast carcinogens, are metabolized by cytochrome P4501A1 (CYP1A1) and glutathione S-transferase (GSTM1). Polycyclic Aromatic Hydrocarbons 0-32 glutathione S-transferase kappa 1 Homo sapiens 120-145 7627950-1 1995 Polycyclic aromatic hydrocarbons, possible human breast carcinogens, are metabolized by cytochrome P4501A1 (CYP1A1) and glutathione S-transferase (GSTM1). Polycyclic Aromatic Hydrocarbons 0-32 glutathione S-transferase mu 1 Homo sapiens 147-152 7627950-2 1995 A CYP1A1 polymorphism (isoleucine to valine substitution in exon 7) or the null allele for GSTM1 may affect the mutagenic potential of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 135-167 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 2-8 7627950-2 1995 A CYP1A1 polymorphism (isoleucine to valine substitution in exon 7) or the null allele for GSTM1 may affect the mutagenic potential of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 135-167 glutathione S-transferase mu 1 Homo sapiens 91-96 7786300-5 1995 It was found that rat and human UGT1.6 and human UGT1.7 catalyse monoglucuronide formation of planar PAH quinols. Polycyclic Aromatic Hydrocarbons 101-104 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 32-38 7786300-5 1995 It was found that rat and human UGT1.6 and human UGT1.7 catalyse monoglucuronide formation of planar PAH quinols. Polycyclic Aromatic Hydrocarbons 101-104 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 49-55 7786300-9 1995 The results suggest that planar PAH phenols and quinols are conjugated more efficiently by human UGT1.7 than by UGT1.6, which preferentially conjugates simple planar phenols. Polycyclic Aromatic Hydrocarbons 32-35 UDP glucuronosyltransferase family 1 member A7 Homo sapiens 97-103 7786300-9 1995 The results suggest that planar PAH phenols and quinols are conjugated more efficiently by human UGT1.7 than by UGT1.6, which preferentially conjugates simple planar phenols. Polycyclic Aromatic Hydrocarbons 32-35 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 112-118 7744798-2 1995 Antibodies against a novel adrenocorticotropic hormone-inducible cytochrome P450 (P450RAP), responsible for polycyclic aromatic hydrocarbon metabolism in rat adrenal microsomes (Otto, S., Bhattacharyya, K.K., and Jefcoate, C.R. Polycyclic Aromatic Hydrocarbons 108-139 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 65-80 7744798-2 1995 Antibodies against a novel adrenocorticotropic hormone-inducible cytochrome P450 (P450RAP), responsible for polycyclic aromatic hydrocarbon metabolism in rat adrenal microsomes (Otto, S., Bhattacharyya, K.K., and Jefcoate, C.R. Polycyclic Aromatic Hydrocarbons 108-139 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 82-89 7663528-1 1995 CYP1A1 is a cytochrome P450 which is inducible by polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 50-82 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 7663528-1 1995 CYP1A1 is a cytochrome P450 which is inducible by polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 84-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 7742722-1 1995 The human CYP1A1 gene codes for an inducible enzyme system involved in biotransformation of certain xenobiotics, including polycyclic aromatic hydrocarbons; some of the metabolites are carcinogenic and mutagenic. Polycyclic Aromatic Hydrocarbons 123-155 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 10-16 8571359-2 1995 Many xenobiotics including pesticides, nitrosamines, polycyclic aromatic hydrocarbons and halogenated hydrocarbons, require bioactivation by P450 enzymes to elicit toxicity. Polycyclic Aromatic Hydrocarbons 53-85 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 141-145 8571376-11 1995 Ki-ras codon 12 mutation analysis of PAH-induced tumors was performed using PCR and dideoxy sequencing methods. Polycyclic Aromatic Hydrocarbons 37-40 Kirsten rat sarcoma viral oncogene homolog Mus musculus 0-6 8674863-10 1995 The constitutive expression and PAH inducibility of CYP1B1 and CYP1A1 proteins in RMF and RMEC, respectively, were each substantially decreased (approximately 75%) by a hormonal mixture (17 beta-estradiol (0.2 microM) progesterone (1.5 microM) cortisol (1.5 microM) and prolactin (5 micrograms/ml)). Polycyclic Aromatic Hydrocarbons 32-35 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 52-58 8674863-10 1995 The constitutive expression and PAH inducibility of CYP1B1 and CYP1A1 proteins in RMF and RMEC, respectively, were each substantially decreased (approximately 75%) by a hormonal mixture (17 beta-estradiol (0.2 microM) progesterone (1.5 microM) cortisol (1.5 microM) and prolactin (5 micrograms/ml)). Polycyclic Aromatic Hydrocarbons 32-35 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 63-69 20650112-8 1995 In conclusion, CYP1A1 mRNA induction was demonstrated in haemopoietic cells; inducers for CYP1A1 were not only a polycyclic aromatic hydrocarbon (BA), but also, unexpectedly, hydroxylated metabolites of benzene. Polycyclic Aromatic Hydrocarbons 113-144 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-21 20650112-8 1995 In conclusion, CYP1A1 mRNA induction was demonstrated in haemopoietic cells; inducers for CYP1A1 were not only a polycyclic aromatic hydrocarbon (BA), but also, unexpectedly, hydroxylated metabolites of benzene. Polycyclic Aromatic Hydrocarbons 113-144 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 90-96 7750161-0 1995 Induction of Cyp1a-1 and Cyp1a-2 gene expression by a reconstituted mixture of polynuclear aromatic hydrocarbons in B6C3F1 mice. Polycyclic Aromatic Hydrocarbons 79-112 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 13-20 7750161-0 1995 Induction of Cyp1a-1 and Cyp1a-2 gene expression by a reconstituted mixture of polynuclear aromatic hydrocarbons in B6C3F1 mice. Polycyclic Aromatic Hydrocarbons 79-112 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 25-32 7750161-1 1995 The potential non-additive interactions of polynuclear aromatic hydrocarbon (PAH) mixtures as inducers of Cyp1a-1 and Cyp1a-2 gene expression were investigated in B6C3F1 mice using a reconstituted PAH mixture. Polycyclic Aromatic Hydrocarbons 77-80 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 106-113 7750161-1 1995 The potential non-additive interactions of polynuclear aromatic hydrocarbon (PAH) mixtures as inducers of Cyp1a-1 and Cyp1a-2 gene expression were investigated in B6C3F1 mice using a reconstituted PAH mixture. Polycyclic Aromatic Hydrocarbons 77-80 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 118-125 7750161-5 1995 The > or = 4-ring PAH fraction and reconstituted mixture induced hepatic microsomal ethoxyresorufin O-deethylase (EROD) activity and Cyp1a-1 mRNA levels, whereas the 2- and 3-ring PAHs were only weakly active. Polycyclic Aromatic Hydrocarbons 21-24 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 136-143 7750161-7 1995 The reconstituted PAH mixture and > or = 4-ring PAHs also induced Cyp1a-2 hepatic mRNA levels and microsomal methoxyresorufin O-deethylase (MROD) activity; however, their dose-response curves indicated that the reconstituted PAH mixture was more potent as a Cyp1a-2 inducer than the > or = 4 ring PAHs. Polycyclic Aromatic Hydrocarbons 18-21 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 69-76 7750161-7 1995 The reconstituted PAH mixture and > or = 4-ring PAHs also induced Cyp1a-2 hepatic mRNA levels and microsomal methoxyresorufin O-deethylase (MROD) activity; however, their dose-response curves indicated that the reconstituted PAH mixture was more potent as a Cyp1a-2 inducer than the > or = 4 ring PAHs. Polycyclic Aromatic Hydrocarbons 18-21 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 261-268 7750161-7 1995 The reconstituted PAH mixture and > or = 4-ring PAHs also induced Cyp1a-2 hepatic mRNA levels and microsomal methoxyresorufin O-deethylase (MROD) activity; however, their dose-response curves indicated that the reconstituted PAH mixture was more potent as a Cyp1a-2 inducer than the > or = 4 ring PAHs. Polycyclic Aromatic Hydrocarbons 51-54 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 69-76 7750161-7 1995 The reconstituted PAH mixture and > or = 4-ring PAHs also induced Cyp1a-2 hepatic mRNA levels and microsomal methoxyresorufin O-deethylase (MROD) activity; however, their dose-response curves indicated that the reconstituted PAH mixture was more potent as a Cyp1a-2 inducer than the > or = 4 ring PAHs. Polycyclic Aromatic Hydrocarbons 51-54 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 261-268 7750161-11 1995 The 3-ring PAHs did not competitively bind to the mouse hepatic cytosolic aryl hydrocarbon (Ah) receptor suggesting that 3-ring PAHs are a new class of Cyp1a-2 inducers which do not act through the Ah receptor. Polycyclic Aromatic Hydrocarbons 11-15 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 152-159 7788860-2 1995 It is well established that the cytochrome P450 (CYP), microsomal epoxide hydrolase (mEH), and other biotransformation enzymes are important modulators of the bioactivation and detoxification of many environmental chemicals, including constituents of tobacco smoke such as certain nitrosamines and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 298-330 uncharacterized protein LOC107819388 Nicotiana tabacum 32-47 7788860-2 1995 It is well established that the cytochrome P450 (CYP), microsomal epoxide hydrolase (mEH), and other biotransformation enzymes are important modulators of the bioactivation and detoxification of many environmental chemicals, including constituents of tobacco smoke such as certain nitrosamines and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 298-330 uncharacterized protein LOC107819388 Nicotiana tabacum 49-52 7788860-2 1995 It is well established that the cytochrome P450 (CYP), microsomal epoxide hydrolase (mEH), and other biotransformation enzymes are important modulators of the bioactivation and detoxification of many environmental chemicals, including constituents of tobacco smoke such as certain nitrosamines and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 298-330 epoxide hydrolase 1, microsomal Mus musculus 85-88 7788860-2 1995 It is well established that the cytochrome P450 (CYP), microsomal epoxide hydrolase (mEH), and other biotransformation enzymes are important modulators of the bioactivation and detoxification of many environmental chemicals, including constituents of tobacco smoke such as certain nitrosamines and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 332-335 uncharacterized protein LOC107819388 Nicotiana tabacum 32-47 7788860-2 1995 It is well established that the cytochrome P450 (CYP), microsomal epoxide hydrolase (mEH), and other biotransformation enzymes are important modulators of the bioactivation and detoxification of many environmental chemicals, including constituents of tobacco smoke such as certain nitrosamines and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 332-335 uncharacterized protein LOC107819388 Nicotiana tabacum 49-52 7788860-2 1995 It is well established that the cytochrome P450 (CYP), microsomal epoxide hydrolase (mEH), and other biotransformation enzymes are important modulators of the bioactivation and detoxification of many environmental chemicals, including constituents of tobacco smoke such as certain nitrosamines and polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 332-335 epoxide hydrolase 1, microsomal Mus musculus 85-88 7788860-10 1995 CYP1A1 and CYP1A2 mRNAs were detected in all the cells and several cultures were inducible by PAH exposure. Polycyclic Aromatic Hydrocarbons 94-97 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 7788860-10 1995 CYP1A1 and CYP1A2 mRNAs were detected in all the cells and several cultures were inducible by PAH exposure. Polycyclic Aromatic Hydrocarbons 94-97 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 11-17 7587946-6 1995 Studies using the glucocorticoid receptor antagonist, RU38486, demonstrated that the modulation of PAH induction by glucocorticoids of cytochrome P4501A1 and QOR activity is apparently dependent on action of the glucocorticoid receptor. Polycyclic Aromatic Hydrocarbons 99-102 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 18-41 7587946-6 1995 Studies using the glucocorticoid receptor antagonist, RU38486, demonstrated that the modulation of PAH induction by glucocorticoids of cytochrome P4501A1 and QOR activity is apparently dependent on action of the glucocorticoid receptor. Polycyclic Aromatic Hydrocarbons 99-102 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 135-153 7587946-6 1995 Studies using the glucocorticoid receptor antagonist, RU38486, demonstrated that the modulation of PAH induction by glucocorticoids of cytochrome P4501A1 and QOR activity is apparently dependent on action of the glucocorticoid receptor. Polycyclic Aromatic Hydrocarbons 99-102 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 212-235 8830563-5 1995 Two enzymes of cytochrome P450, CYP1A1 and CYP1A2, are inducible by tobacco carcinogens, and animal studies evidenced a genetic polymorphism of CYP1A1 associated with tumour occurrence after administration of a polycyclic aromatic hydrocarbon. Polycyclic Aromatic Hydrocarbons 211-242 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 32-38 7954461-0 1994 Pan-fried meat containing high levels of heterocyclic aromatic amines but low levels of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans. Polycyclic Aromatic Hydrocarbons 88-120 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 129-147 7600448-1 1995 In liver of adult responsive C57BL/6J (B6) mice the aromatic hydrocarbon receptor (AHR) has high affinity for specific halogenated aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), as well as nonhalogenated aromatic hydrocarbons (PAHs), such as benz[a]anthracene (BA) or 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons 255-259 aryl-hydrocarbon receptor Mus musculus 52-81 7600448-1 1995 In liver of adult responsive C57BL/6J (B6) mice the aromatic hydrocarbon receptor (AHR) has high affinity for specific halogenated aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), as well as nonhalogenated aromatic hydrocarbons (PAHs), such as benz[a]anthracene (BA) or 3-methylcholanthrene (MC). Polycyclic Aromatic Hydrocarbons 255-259 aryl-hydrocarbon receptor Mus musculus 83-86 7600448-4 1995 In fetal cell cultures derived from D2 mice AHH is induced by PAHs such as MC or BA, and these PAHs bind to cytosolic AHR (P.A. Polycyclic Aromatic Hydrocarbons 95-99 aryl-hydrocarbon receptor Mus musculus 118-121 7600455-1 1995 The aromatic hydrocarbon receptor (AHR) is a soluble intracellular protein that mediates most, if not all, the toxic effects of polycyclic aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 3-methylcholanthrene. Polycyclic Aromatic Hydrocarbons 128-160 aryl hydrocarbon receptor Homo sapiens 4-33 7600455-1 1995 The aromatic hydrocarbon receptor (AHR) is a soluble intracellular protein that mediates most, if not all, the toxic effects of polycyclic aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and 3-methylcholanthrene. Polycyclic Aromatic Hydrocarbons 128-160 aryl hydrocarbon receptor Homo sapiens 35-38 7720764-1 1995 CYP1A2 is a cytochrome P450 which is inducible by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 50-82 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-6 7581496-5 1995 Thus pulmonary CYP1A1 expression (inducibility) controls in part polycyclic aromatic hydrocarbon-DNA adduct formation in tobacco smokers and, therefore, appears to be associated with lung cancer risk. Polycyclic Aromatic Hydrocarbons 65-96 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-21 7581497-2 1995 Here, the application of rat and human CYP1A1 and CYP1A2 is demonstrated for comparative studies on the oxidation of polycyclic aromatic hydrocarbons, such as phenanthrene, benz[a]anthracene, and benzo[a]pyrene. Polycyclic Aromatic Hydrocarbons 117-149 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 39-45 7581497-2 1995 Here, the application of rat and human CYP1A1 and CYP1A2 is demonstrated for comparative studies on the oxidation of polycyclic aromatic hydrocarbons, such as phenanthrene, benz[a]anthracene, and benzo[a]pyrene. Polycyclic Aromatic Hydrocarbons 117-149 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 50-56 7954461-3 1994 While activity of NAT2 is noninducible, exposure to cigarettes, polycyclic aromatic hydrocarbons, and cruciferous vegetables has been shown to induce CYP1A2 activity in humans. Polycyclic Aromatic Hydrocarbons 64-96 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 150-156 8001254-1 1994 Carcinogen-DNA adducts and somatic gene mutation at the hypoxanthine guanine phosphoribosyl transferase (HPRT) locus were evaluated in peripheral leukocytes of workers in an iron foundry with exposure to benzo[a]pyrene (B[a]P) and other polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 237-269 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 105-109 8001254-1 1994 Carcinogen-DNA adducts and somatic gene mutation at the hypoxanthine guanine phosphoribosyl transferase (HPRT) locus were evaluated in peripheral leukocytes of workers in an iron foundry with exposure to benzo[a]pyrene (B[a]P) and other polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 271-275 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 105-109 7737047-6 1994 For example, a restriction fragment-length polymorphism for cytochrome P4501A1, which metabolizes polycyclic aromatic hydrocarbons, and cytochrome P4502E1, which metabolizes N-nitrosamines and benzene, is linked to lung cancer risk. Polycyclic Aromatic Hydrocarbons 98-130 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 60-78 8001254-11 1994 However, when analysis was restricted to workers with detectable levels of adducts (who included the more highly exposed workers) the correlation was significant between PAH-DNA and HPRT (n = 17; r = 0.65; P = 0.005). Polycyclic Aromatic Hydrocarbons 170-173 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 182-186 8001258-2 1994 These molecules are polycyclic aromatic hydrocarbons (PAHs) that have, respectively, two hindered bay regions and two fjord regions; the former PAH is a known carcinogen. Polycyclic Aromatic Hydrocarbons 20-52 phenylalanine hydroxylase Homo sapiens 54-57 7808430-8 1994 Our results demonstrate that IL-1 beta, TNF-alpha, and IFNs antagonized PAH-mediated induction of CYP1A gene expression in human hepatocytes. Polycyclic Aromatic Hydrocarbons 72-75 interleukin 1 beta Homo sapiens 29-38 7808430-8 1994 Our results demonstrate that IL-1 beta, TNF-alpha, and IFNs antagonized PAH-mediated induction of CYP1A gene expression in human hepatocytes. Polycyclic Aromatic Hydrocarbons 72-75 tumor necrosis factor Homo sapiens 40-49 7955090-0 1994 Polycyclic aromatic hydrocarbon-DNA adducts in smokers and their relationship to micronutrient levels and the glutathione-S-transferase M1 genotype. Polycyclic Aromatic Hydrocarbons 0-31 glutathione S-transferase mu 1 Homo sapiens 110-138 7888077-5 1994 Finally, the induction of human GSTs by drugs or nutritional constituents would justify an interest for developing chemointervention strategies in populations highly exposed to carcinogens like aflatoxin B1 and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 211-243 glutathione S-transferase alpha 1 Homo sapiens 32-36 7955041-11 1994 In comparison with previous studies of other polynuclear aromatic hydrocarbons and their metabolites, the results suggest that the reactivity with DNA of anti-B[c]PhDE is one factor involved in the induction of A mutations in Ha-ras genes in mouse skin, but further studies are required to evaluate the significance of these mutations in mouse skin tumorigenesis. Polycyclic Aromatic Hydrocarbons 45-78 Harvey rat sarcoma virus oncogene Mus musculus 226-232 8069857-7 1994 Thus, these results suggest that the DNA adducts detected in human larynx are largely derived from metabolic activation of polycyclic aromatic hydrocarbons in cigarette smoke by P450 2C, 3A4, and/or 1A1. Polycyclic Aromatic Hydrocarbons 123-155 olfactory receptor family 1 subfamily A member 1 Homo sapiens 196-202 7923575-1 1994 Cytochrome P450 1A1 (CYP1A1) activity is associated with increased susceptibility to lung cancer induced by polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BP). Polycyclic Aromatic Hydrocarbons 108-140 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 7923575-1 1994 Cytochrome P450 1A1 (CYP1A1) activity is associated with increased susceptibility to lung cancer induced by polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BP). Polycyclic Aromatic Hydrocarbons 108-140 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 7923575-8 1994 The results suggest that modestly induced CYP1A1 activity is a risk factor in polycyclic aromatic hydrocarbon-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 78-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-48 8204108-3 1994 Thus, changes in the activity of glutathione S-transferase in vascular tissue could affect the risk of polycyclic aromatic hydrocarbon-induced atherogenesis. Polycyclic Aromatic Hydrocarbons 103-134 hematopoietic prostaglandin D synthase Rattus norvegicus 33-58 7980619-1 1994 Indirect evidence has suggested that multiple subunits of microsomal UDP-glucuronosyltransferases (UGTs) are involved in diglucuronide formation of diphenols of polycyclic aromatic hydrocarbons (Bock et al., Mol Pharmacol 42: 613-618, 1992). Polycyclic Aromatic Hydrocarbons 161-193 beta-1,3-glucuronyltransferase 2 Homo sapiens 69-97 7980619-1 1994 Indirect evidence has suggested that multiple subunits of microsomal UDP-glucuronosyltransferases (UGTs) are involved in diglucuronide formation of diphenols of polycyclic aromatic hydrocarbons (Bock et al., Mol Pharmacol 42: 613-618, 1992). Polycyclic Aromatic Hydrocarbons 161-193 beta-1,3-glucuronyltransferase 2 Homo sapiens 99-103 7980619-7 1994 In contrast, UGTs involved in diglucuronide formation of diphenols of polycyclic aromatic hydrocarbons may function as tetramers in microsomes in situ. Polycyclic Aromatic Hydrocarbons 70-102 beta-1,3-glucuronyltransferase 2 Homo sapiens 13-17 8033271-6 1994 In addition, rat hepatic hydroxysteroid sulfotransferase-a gene expression in mature female rats, although not substantially altered in response to short-term fasting or high-dose dexamethasone treatment, was suppressed after treatment with the polycyclic aromatic hydrocarbon, 3-methylcholanthrene. Polycyclic Aromatic Hydrocarbons 245-276 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6 Rattus norvegicus 25-58 8195121-15 1994 Compared with the beta-NF-induced uterus, polycyclic aromatic hydrocarbon-induced uterine fibroblasts exhibited 10-20-fold higher levels of CYP1B1, suggesting that stromal fibroblasts are a major source of the protein. Polycyclic Aromatic Hydrocarbons 42-73 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 140-146 8056202-0 1994 Chemical structure- and time-dependent effects of polycyclic aromatic hydrocarbon-type inducers on rat liver cytochrome P450, DNA adducts, and I-compounds. Polycyclic Aromatic Hydrocarbons 50-81 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 109-124 8120057-2 1994 The gene for cytochrome P4501A2 is constitutively expressed in the liver of vertebrates and shows induced expression when an organism is exposed to polycyclic aromatic hydrocarbons and halogenated hydrocarbons. Polycyclic Aromatic Hydrocarbons 148-180 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 13-31 8163516-1 1994 Halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons such as 3-methylcholanthrene (MC) cause transcriptional activation of the CYP1A1 gene via their interaction with the aromatic hydrocarbon (Ah) receptor. Polycyclic Aromatic Hydrocarbons 89-121 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 196-202 8163516-1 1994 Halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons such as 3-methylcholanthrene (MC) cause transcriptional activation of the CYP1A1 gene via their interaction with the aromatic hydrocarbon (Ah) receptor. Polycyclic Aromatic Hydrocarbons 89-121 aryl-hydrocarbon receptor Mus musculus 239-273 8119914-4 1994 Polyclonal antibodies to GNMT immunoprecipitated PAH-binding activity from rat liver cytosol. Polycyclic Aromatic Hydrocarbons 49-52 glycine N-methyltransferase Rattus norvegicus 25-29 8128488-4 1994 The phase I drug metabolizing enzyme cytochrome P450 1A1 (CYP1A1) provides a major pathway for polycyclic aromatic hydrocarbon (PAH) carcinogen activation, whereas HST-a, through enzymatic sulfation, offers an alternative pathway for PAH carcinogen activation. Polycyclic Aromatic Hydrocarbons 95-126 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 37-56 8128488-4 1994 The phase I drug metabolizing enzyme cytochrome P450 1A1 (CYP1A1) provides a major pathway for polycyclic aromatic hydrocarbon (PAH) carcinogen activation, whereas HST-a, through enzymatic sulfation, offers an alternative pathway for PAH carcinogen activation. Polycyclic Aromatic Hydrocarbons 95-126 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 58-64 8128488-4 1994 The phase I drug metabolizing enzyme cytochrome P450 1A1 (CYP1A1) provides a major pathway for polycyclic aromatic hydrocarbon (PAH) carcinogen activation, whereas HST-a, through enzymatic sulfation, offers an alternative pathway for PAH carcinogen activation. Polycyclic Aromatic Hydrocarbons 95-126 fibroblast growth factor 4 Rattus norvegicus 164-167 8128488-4 1994 The phase I drug metabolizing enzyme cytochrome P450 1A1 (CYP1A1) provides a major pathway for polycyclic aromatic hydrocarbon (PAH) carcinogen activation, whereas HST-a, through enzymatic sulfation, offers an alternative pathway for PAH carcinogen activation. Polycyclic Aromatic Hydrocarbons 128-131 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 37-56 8128488-4 1994 The phase I drug metabolizing enzyme cytochrome P450 1A1 (CYP1A1) provides a major pathway for polycyclic aromatic hydrocarbon (PAH) carcinogen activation, whereas HST-a, through enzymatic sulfation, offers an alternative pathway for PAH carcinogen activation. Polycyclic Aromatic Hydrocarbons 128-131 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 58-64 8128488-4 1994 The phase I drug metabolizing enzyme cytochrome P450 1A1 (CYP1A1) provides a major pathway for polycyclic aromatic hydrocarbon (PAH) carcinogen activation, whereas HST-a, through enzymatic sulfation, offers an alternative pathway for PAH carcinogen activation. Polycyclic Aromatic Hydrocarbons 128-131 fibroblast growth factor 4 Rattus norvegicus 164-167 8128488-4 1994 The phase I drug metabolizing enzyme cytochrome P450 1A1 (CYP1A1) provides a major pathway for polycyclic aromatic hydrocarbon (PAH) carcinogen activation, whereas HST-a, through enzymatic sulfation, offers an alternative pathway for PAH carcinogen activation. Polycyclic Aromatic Hydrocarbons 234-237 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 37-56 8128488-4 1994 The phase I drug metabolizing enzyme cytochrome P450 1A1 (CYP1A1) provides a major pathway for polycyclic aromatic hydrocarbon (PAH) carcinogen activation, whereas HST-a, through enzymatic sulfation, offers an alternative pathway for PAH carcinogen activation. Polycyclic Aromatic Hydrocarbons 234-237 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 58-64 8128488-4 1994 The phase I drug metabolizing enzyme cytochrome P450 1A1 (CYP1A1) provides a major pathway for polycyclic aromatic hydrocarbon (PAH) carcinogen activation, whereas HST-a, through enzymatic sulfation, offers an alternative pathway for PAH carcinogen activation. Polycyclic Aromatic Hydrocarbons 234-237 fibroblast growth factor 4 Rattus norvegicus 164-167 8128488-5 1994 Transcription of the rat hepatic CYP1A1 gene is induced in response to treatment with PAH carcinogen 3-methylcholanthrene (3-MC). Polycyclic Aromatic Hydrocarbons 86-89 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 33-39 7515872-1 1994 3 alpha-Hydroxysteroid dehydrogenase (3 alpha-HSD) [EC 1.1.1.213]2 plays important multifunctional roles in metabolizing steroid hormones, polycyclic aromatic hydrocarbons, and prostaglandins and also in transforming the steroid nucleus for the biosynthesis of bile acids from cholesterol in liver. Polycyclic Aromatic Hydrocarbons 139-171 aldo-keto reductase family 1, member C14 Rattus norvegicus 0-36 7515872-1 1994 3 alpha-Hydroxysteroid dehydrogenase (3 alpha-HSD) [EC 1.1.1.213]2 plays important multifunctional roles in metabolizing steroid hormones, polycyclic aromatic hydrocarbons, and prostaglandins and also in transforming the steroid nucleus for the biosynthesis of bile acids from cholesterol in liver. Polycyclic Aromatic Hydrocarbons 139-171 aldo-keto reductase family 1, member C14 Rattus norvegicus 38-49 8261447-1 1994 Dihydrodiol dehydrogenase (DD; EC 1.3.1.20) catalyzes a novel pathway of polycyclic aromatic hydrocarbon (PAH) metabolism in which trans-dihydrodiols (proximate carcinogens) are oxidized to reactive o-quinones which are cytotoxic and genotoxic. Polycyclic Aromatic Hydrocarbons 73-104 dihydrodiol dehydrogenase Rattus norvegicus 0-25 8261447-1 1994 Dihydrodiol dehydrogenase (DD; EC 1.3.1.20) catalyzes a novel pathway of polycyclic aromatic hydrocarbon (PAH) metabolism in which trans-dihydrodiols (proximate carcinogens) are oxidized to reactive o-quinones which are cytotoxic and genotoxic. Polycyclic Aromatic Hydrocarbons 73-104 dihydrodiol dehydrogenase Rattus norvegicus 27-29 8261447-1 1994 Dihydrodiol dehydrogenase (DD; EC 1.3.1.20) catalyzes a novel pathway of polycyclic aromatic hydrocarbon (PAH) metabolism in which trans-dihydrodiols (proximate carcinogens) are oxidized to reactive o-quinones which are cytotoxic and genotoxic. Polycyclic Aromatic Hydrocarbons 106-109 dihydrodiol dehydrogenase Rattus norvegicus 0-25 8261447-1 1994 Dihydrodiol dehydrogenase (DD; EC 1.3.1.20) catalyzes a novel pathway of polycyclic aromatic hydrocarbon (PAH) metabolism in which trans-dihydrodiols (proximate carcinogens) are oxidized to reactive o-quinones which are cytotoxic and genotoxic. Polycyclic Aromatic Hydrocarbons 106-109 dihydrodiol dehydrogenase Rattus norvegicus 27-29 8261447-16 1994 These data indicate that DD gene expression is hormonally regulated, that estrogens exert their effect at the level of the mRNA, and that aldo-keto reductases involved in PAH metabolism may have their expression regulated by female sex hormones. Polycyclic Aromatic Hydrocarbons 171-174 dihydrodiol dehydrogenase Rattus norvegicus 25-27 8269543-7 1993 For the EROD and CYP1A1 mRNA induction and cytosolic transformation activities and immunosuppressive effects, the MGP-PAH mixture was approximately 100-900 times more potent as an Ah receptor agonist than expected based on its benzo[a]pyrene content. Polycyclic Aromatic Hydrocarbons 118-121 aryl hydrocarbon receptor Homo sapiens 180-191 8269543-0 1993 Synergistic activity of polynuclear aromatic hydrocarbon mixtures as aryl hydrocarbon (Ah) receptor agonists. Polycyclic Aromatic Hydrocarbons 24-56 aryl hydrocarbon receptor Homo sapiens 69-99 7901425-5 1993 These results demonstrate racially distinct patterns of CYP1A1 genotypes, and suggest a functional link between genotype and catalytic activity of the cytochrome P-450 protein responsible for the metabolism of many carcinogenic polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 228-260 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 56-62 7901425-5 1993 These results demonstrate racially distinct patterns of CYP1A1 genotypes, and suggest a functional link between genotype and catalytic activity of the cytochrome P-450 protein responsible for the metabolism of many carcinogenic polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 228-260 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 151-167 7508716-3 1993 Taking 1.5 as a borderline value for the BghiPer/BaP ratio, a significant influence of car traffic on air pollution by polycyclic aromatic hydrocarbons was noticed at a site close to a petrol station. Polycyclic Aromatic Hydrocarbons 119-151 prohibitin 2 Homo sapiens 49-52 8220094-2 1993 Recently described genetic polymorphisms for CYP1A1, a gene involved in the metabolic activation of polycyclic aromatic hydrocarbons, have been associated with lung cancer risk in a Japanese population. Polycyclic Aromatic Hydrocarbons 100-132 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 45-51 8339251-13 1993 Multivariate analysis indicated that only the GST mu genotype was associated with polycyclic aromatic hydrocarbon-DNA adduct levels. Polycyclic Aromatic Hydrocarbons 82-113 glutathione S-transferase mu 1 Homo sapiens 46-52 8353849-2 1993 In particular, cytochrome P450 1A1 (CYP1A1) catalyzes the conversion of polycyclic aromatic hydrocarbons, such as benzo[a]pyrene, into potent mutagenic agents. Polycyclic Aromatic Hydrocarbons 72-104 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-34 8353849-2 1993 In particular, cytochrome P450 1A1 (CYP1A1) catalyzes the conversion of polycyclic aromatic hydrocarbons, such as benzo[a]pyrene, into potent mutagenic agents. Polycyclic Aromatic Hydrocarbons 72-104 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 8314401-4 1993 As demonstrated in the experiment, the lowering of PAHs concentration in the liquid smoke flavour UTP-1 was due to the sorption of PAHs on packaging material, in which PAHs were found at the end of the experiment. Polycyclic Aromatic Hydrocarbons 51-55 PWP2 small subunit processome component Homo sapiens 98-103 8222045-3 1993 Many polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene, and chlorinated PAH such as polychlorinated dibenzodioxins, dibenzofurans and biphenyls induce CYP1A1 expression through activation of an endogenous protein, the Ah receptor. Polycyclic Aromatic Hydrocarbons 5-37 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 163-169 8222045-3 1993 Many polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene, and chlorinated PAH such as polychlorinated dibenzodioxins, dibenzofurans and biphenyls induce CYP1A1 expression through activation of an endogenous protein, the Ah receptor. Polycyclic Aromatic Hydrocarbons 5-37 aryl hydrocarbon receptor Homo sapiens 230-241 8222045-3 1993 Many polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene, and chlorinated PAH such as polychlorinated dibenzodioxins, dibenzofurans and biphenyls induce CYP1A1 expression through activation of an endogenous protein, the Ah receptor. Polycyclic Aromatic Hydrocarbons 39-42 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 163-169 8222045-3 1993 Many polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene, and chlorinated PAH such as polychlorinated dibenzodioxins, dibenzofurans and biphenyls induce CYP1A1 expression through activation of an endogenous protein, the Ah receptor. Polycyclic Aromatic Hydrocarbons 39-42 aryl hydrocarbon receptor Homo sapiens 230-241 8222045-3 1993 Many polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene, and chlorinated PAH such as polychlorinated dibenzodioxins, dibenzofurans and biphenyls induce CYP1A1 expression through activation of an endogenous protein, the Ah receptor. Polycyclic Aromatic Hydrocarbons 84-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 163-169 8222045-3 1993 Many polycyclic aromatic hydrocarbons (PAH) such as benzo[a]pyrene, and chlorinated PAH such as polychlorinated dibenzodioxins, dibenzofurans and biphenyls induce CYP1A1 expression through activation of an endogenous protein, the Ah receptor. Polycyclic Aromatic Hydrocarbons 84-87 aryl hydrocarbon receptor Homo sapiens 230-241 7685581-2 1993 When reduction of polycyclic aromatic hydrocarbons is compared, there are differences between the human placental carbonyl reductase, rat liver DT-diaphorase, and Clostridium DT-diaphorase. Polycyclic Aromatic Hydrocarbons 18-50 dehydrogenase/reductase 4 Rattus norvegicus 114-132 7685581-2 1993 When reduction of polycyclic aromatic hydrocarbons is compared, there are differences between the human placental carbonyl reductase, rat liver DT-diaphorase, and Clostridium DT-diaphorase. Polycyclic Aromatic Hydrocarbons 18-50 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 144-157 7685581-2 1993 When reduction of polycyclic aromatic hydrocarbons is compared, there are differences between the human placental carbonyl reductase, rat liver DT-diaphorase, and Clostridium DT-diaphorase. Polycyclic Aromatic Hydrocarbons 18-50 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 175-188 8504491-0 1993 HPRT and glycophorin A mutations in foundry workers: relationship to PAH exposure and to PAH-DNA adducts. Polycyclic Aromatic Hydrocarbons 69-72 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 0-4 8504491-0 1993 HPRT and glycophorin A mutations in foundry workers: relationship to PAH exposure and to PAH-DNA adducts. Polycyclic Aromatic Hydrocarbons 89-92 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 0-4 8504491-0 1993 HPRT and glycophorin A mutations in foundry workers: relationship to PAH exposure and to PAH-DNA adducts. Polycyclic Aromatic Hydrocarbons 89-92 glycophorin A (MNS blood group) Homo sapiens 9-22 8472345-1 1993 Cyclopenta[c,d]pyrene (CPP) is a widespread polycyclic aromatic hydrocarbon with potent mutagenic and carcinogenic activity. Polycyclic Aromatic Hydrocarbons 44-75 Calbindin 53E Drosophila melanogaster 2-3 8472345-1 1993 Cyclopenta[c,d]pyrene (CPP) is a widespread polycyclic aromatic hydrocarbon with potent mutagenic and carcinogenic activity. Polycyclic Aromatic Hydrocarbons 44-75 dacapo Drosophila melanogaster 9-10 8386305-1 1993 In the presence of halogenated and polycyclic aromatic hydrocarbons, the CYP1A1 gene is regulated through induction after ligand binding to the cytosolic Ah receptor (AhR). Polycyclic Aromatic Hydrocarbons 35-67 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-79 8386305-1 1993 In the presence of halogenated and polycyclic aromatic hydrocarbons, the CYP1A1 gene is regulated through induction after ligand binding to the cytosolic Ah receptor (AhR). Polycyclic Aromatic Hydrocarbons 35-67 aryl hydrocarbon receptor Homo sapiens 154-165 8386305-1 1993 In the presence of halogenated and polycyclic aromatic hydrocarbons, the CYP1A1 gene is regulated through induction after ligand binding to the cytosolic Ah receptor (AhR). Polycyclic Aromatic Hydrocarbons 35-67 aryl hydrocarbon receptor Homo sapiens 167-170 8319640-1 1993 Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). Polycyclic Aromatic Hydrocarbons 56-88 phenylalanine hydroxylase Homo sapiens 90-93 8156173-1 1993 Using reverse transcriptase-linked polymerase chain reaction, the effect of polycyclic aromatic hydrocarbons (PAHs) on IL-1 alpha, IL-1 beta and IL-6 gene expression in cultured human keratinocytes was studied. Polycyclic Aromatic Hydrocarbons 76-108 interleukin 1 alpha Homo sapiens 119-129 8156173-1 1993 Using reverse transcriptase-linked polymerase chain reaction, the effect of polycyclic aromatic hydrocarbons (PAHs) on IL-1 alpha, IL-1 beta and IL-6 gene expression in cultured human keratinocytes was studied. Polycyclic Aromatic Hydrocarbons 76-108 interleukin 6 Homo sapiens 145-149 8156173-1 1993 Using reverse transcriptase-linked polymerase chain reaction, the effect of polycyclic aromatic hydrocarbons (PAHs) on IL-1 alpha, IL-1 beta and IL-6 gene expression in cultured human keratinocytes was studied. Polycyclic Aromatic Hydrocarbons 110-114 interleukin 1 alpha Homo sapiens 119-129 8156173-1 1993 Using reverse transcriptase-linked polymerase chain reaction, the effect of polycyclic aromatic hydrocarbons (PAHs) on IL-1 alpha, IL-1 beta and IL-6 gene expression in cultured human keratinocytes was studied. Polycyclic Aromatic Hydrocarbons 110-114 interleukin 1 beta Homo sapiens 131-140 8156173-1 1993 Using reverse transcriptase-linked polymerase chain reaction, the effect of polycyclic aromatic hydrocarbons (PAHs) on IL-1 alpha, IL-1 beta and IL-6 gene expression in cultured human keratinocytes was studied. Polycyclic Aromatic Hydrocarbons 110-114 interleukin 6 Homo sapiens 145-149 8314401-4 1993 As demonstrated in the experiment, the lowering of PAHs concentration in the liquid smoke flavour UTP-1 was due to the sorption of PAHs on packaging material, in which PAHs were found at the end of the experiment. Polycyclic Aromatic Hydrocarbons 131-135 PWP2 small subunit processome component Homo sapiens 98-103 8314401-4 1993 As demonstrated in the experiment, the lowering of PAHs concentration in the liquid smoke flavour UTP-1 was due to the sorption of PAHs on packaging material, in which PAHs were found at the end of the experiment. Polycyclic Aromatic Hydrocarbons 131-135 PWP2 small subunit processome component Homo sapiens 98-103 8319138-1 1993 Characterization of cytochrome P450 1A1 dependent monooxygenases in guinea pig heart revealed low rates of 7-ethoxyresorufin O-deethylation, which are markedly increased (20-fold) by treatment with beta-naphthoflavone, a polycyclic aromatic hydrocarbon. Polycyclic Aromatic Hydrocarbons 221-252 cytochrome P450 1A1 Cavia porcellus 20-39 8504491-8 1993 In contrast, HPRT mutations were highly correlated with PAH-DNA adducts (r = 0.67; P = 0.004). Polycyclic Aromatic Hydrocarbons 56-59 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 13-17 8504491-14 1993 Thus, the most interesting and novel finding is that, even at relatively low exposures to PAH, HPRT mutations were increased in parallel with PAH-DNA adducts. Polycyclic Aromatic Hydrocarbons 90-93 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 95-99 8504491-14 1993 Thus, the most interesting and novel finding is that, even at relatively low exposures to PAH, HPRT mutations were increased in parallel with PAH-DNA adducts. Polycyclic Aromatic Hydrocarbons 142-145 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 95-99 8504491-15 1993 The observed association between PAH-DNA adducts and HPRT gene mutation in humans is consistent with experimental data for PAHs. Polycyclic Aromatic Hydrocarbons 33-36 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 53-57 8319138-6 1993 The biological significance of these low levels of cytochrome P450 1A1 monooxygenase activity in guinea pig heart and their induction by polycyclic aromatic hydrocarbons are not currently understood. Polycyclic Aromatic Hydrocarbons 137-169 cytochrome P450 1A1 Cavia porcellus 51-70 8442004-0 1993 Response of human CYP1-luciferase plasmids to 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 86-118 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 18-22 8442004-1 1993 The cytochrome P4501 gene family consists of two members, CYP1A1 and CYP1A2, that are induced by halogenated hydrocarbons and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 126-158 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 58-64 8442004-1 1993 The cytochrome P4501 gene family consists of two members, CYP1A1 and CYP1A2, that are induced by halogenated hydrocarbons and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 126-158 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 69-75 8093594-9 1993 These studies, along with our previous survey of CYP1A1 gene expression in creosote-exposed workers, add further support to the use of CYP1A1 gene inducibility as a potential marker of polycyclic aromatic hydrocarbon exposure in human populations. Polycyclic Aromatic Hydrocarbons 185-216 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 135-141 8412183-1 1993 Chronic inhalation exposure to environmental carcinogens such as polycyclic aromatic hydrocarbons (PAHs), cigarette smoke, 4-aminobiphenyl (4-ABP), ethylene oxide, and styrene is associated with elevations in biomarkers such as DNA adducts, protein adducts, sister chromatid exchanges (SCEs), chromosomal aberrations, gene mutation, and/or oncogene activation. Polycyclic Aromatic Hydrocarbons 65-97 amine oxidase copper containing 1 Homo sapiens 142-145 9857304-2 1993 This enzyme may be induced by a variety of Polycyclic Aromatic Hydrocarbons (PAHs) and the AHH inducibility is associated with harmful effects of environmental chemicals. Polycyclic Aromatic Hydrocarbons 43-75 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 91-94 9857304-2 1993 This enzyme may be induced by a variety of Polycyclic Aromatic Hydrocarbons (PAHs) and the AHH inducibility is associated with harmful effects of environmental chemicals. Polycyclic Aromatic Hydrocarbons 77-81 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 91-94 8280375-0 1993 Further analysis of c-Ha-ras mutations in papillomas initiated by several polycyclic aromatic hydrocarbons and papillomas from uninitiated, promoter-treated skin in SENCAR mice. Polycyclic Aromatic Hydrocarbons 74-106 Harvey rat sarcoma virus oncogene Mus musculus 20-28 8423501-4 1993 Cytochrome P4501A1, P4502E1 and N-acetyl transferase 2 are examples of enzymes involved in the metabolic activation of potential environmental carcinogens such as polycyclic aromatic hydrocarbons, benzene, and aromatic amines, respectively. Polycyclic Aromatic Hydrocarbons 163-195 N-acetyltransferase 2 Homo sapiens 20-54 1335374-8 1992 These data suggest that the Ah receptor liganded with MC and related PAHs induced a broad spectrum of antiestrogenic responses in MCF-7 cells and complements the results of previous studies which report the antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and other halogenated aromatics which are also Ah receptor agonists. Polycyclic Aromatic Hydrocarbons 69-73 aryl hydrocarbon receptor Homo sapiens 28-39 1335374-8 1992 These data suggest that the Ah receptor liganded with MC and related PAHs induced a broad spectrum of antiestrogenic responses in MCF-7 cells and complements the results of previous studies which report the antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and other halogenated aromatics which are also Ah receptor agonists. Polycyclic Aromatic Hydrocarbons 69-73 aryl hydrocarbon receptor Homo sapiens 316-327 1332854-0 1992 Polycyclic aromatic hydrocarbon metabolism in rat adrenal, ovary, and testis microsomes is catalyzed by the same novel cytochrome P450 (P450RAP). Polycyclic Aromatic Hydrocarbons 0-31 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 136-143 1332854-1 1992 A novel ACTH-inducible P450, cytochrome P450RAP, is responsible for polycyclic aromatic hydrocarbon (PAH) metabolism in male rat adrenal microsomes. Polycyclic Aromatic Hydrocarbons 68-99 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 29-47 1332854-1 1992 A novel ACTH-inducible P450, cytochrome P450RAP, is responsible for polycyclic aromatic hydrocarbon (PAH) metabolism in male rat adrenal microsomes. Polycyclic Aromatic Hydrocarbons 101-104 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 29-47 1332854-9 1992 This close correlation between PAH metabolism and expression of P450RAP indicates the involvement of the cytochrome in this activity. Polycyclic Aromatic Hydrocarbons 31-34 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 64-71 1332854-11 1992 Essentially all of the PAH metabolism in rat adrenal, testis, and ovary is, therefore, catalyzed by P450RAP, which is hormonally elevated in each tissue by a variety of possible mechanisms, including induction and selective proliferation of cells that express this protein. Polycyclic Aromatic Hydrocarbons 23-26 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 100-107 1416973-1 1992 The 4 S polycyclic aromatic hydrocarbon (PAH)-binding protein (PBP) is a soluble protein that binds PAHs with high affinity in mouse, rat, and rabbit. Polycyclic Aromatic Hydrocarbons 8-39 phosphatidylethanolamine binding protein 1 Mus musculus 63-66 1416973-1 1992 The 4 S polycyclic aromatic hydrocarbon (PAH)-binding protein (PBP) is a soluble protein that binds PAHs with high affinity in mouse, rat, and rabbit. Polycyclic Aromatic Hydrocarbons 100-104 phosphatidylethanolamine binding protein 1 Mus musculus 63-66 1302569-1 1992 Cortisol is metabolized to 6 beta-hydroxycortisol by the human cytochrome P-450 3A4, an enzyme implicated in the critical epoxidation reactions of aflatoxin B1 and certain polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 172-204 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 63-83 1336724-1 1992 The main polycyclic aromatic hydrocarbon-inducible cytochrome P450 was studied in lung tissue from 57 lung cancer patients by immunohistochemistry, using a monoclonal antibody (1-7-1) that recognizes P450IA1 and P450IA2 isozymes. Polycyclic Aromatic Hydrocarbons 9-40 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 51-66 1486868-2 1992 Of the numerous components of tobacco smoke, the polycyclic aromatic hydrocarbons appear to be the principal compounds that yield substrates for these enzymes, GSTM1-1 being effective with those PAH derivatives so far studied; however, the gene locus for GSTM1 is polymorphic, containing two well-characterized expressing genes and a null allele. Polycyclic Aromatic Hydrocarbons 49-81 glutathione S-transferase mu 1 Homo sapiens 160-167 1486868-2 1992 Of the numerous components of tobacco smoke, the polycyclic aromatic hydrocarbons appear to be the principal compounds that yield substrates for these enzymes, GSTM1-1 being effective with those PAH derivatives so far studied; however, the gene locus for GSTM1 is polymorphic, containing two well-characterized expressing genes and a null allele. Polycyclic Aromatic Hydrocarbons 195-198 glutathione S-transferase mu 1 Homo sapiens 160-167 1486868-2 1992 Of the numerous components of tobacco smoke, the polycyclic aromatic hydrocarbons appear to be the principal compounds that yield substrates for these enzymes, GSTM1-1 being effective with those PAH derivatives so far studied; however, the gene locus for GSTM1 is polymorphic, containing two well-characterized expressing genes and a null allele. Polycyclic Aromatic Hydrocarbons 195-198 glutathione S-transferase mu 1 Homo sapiens 160-165 1362539-8 1992 A recently described restriction fragment length polymorphism for the CYP1A1, which codes for the cytochrome P450 enzyme primarily responsible for the metabolic activation of carcinogenic polycyclic aromatic hydrocarbons, has been found to be associated with lung cancer risk in a Japanese population. Polycyclic Aromatic Hydrocarbons 188-220 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 70-76 1344831-4 1992 Omeprazole interacts with the cytochrome P-450 system in the liver: inhibition of several liver mono-oxygenases activities (inhibitory effect on diazepam, phenytoin and R-warfarin metabolism with prolonged elimination); induction of P-450 (IA1 and IA2) enzymes that may potentiate the hepatotoxic effect of phenacetin and acetaminophen or increase the tumorigenic effect of chemical carcinogens (polycyclic aromatic hydrocarbons, arylamines, aflatoxin). Polycyclic Aromatic Hydrocarbons 396-428 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 30-46 8280375-10 1993 The results suggest that more than one mechanism may contribute to activation of c-Ha-ras by polycyclic aromatic hydrocarbons (PAHs) in mouse skin. Polycyclic Aromatic Hydrocarbons 93-125 POC1 centriolar protein A Mus musculus 81-85 8280375-10 1993 The results suggest that more than one mechanism may contribute to activation of c-Ha-ras by polycyclic aromatic hydrocarbons (PAHs) in mouse skin. Polycyclic Aromatic Hydrocarbons 127-131 POC1 centriolar protein A Mus musculus 81-85 1505055-1 1992 The mouse hepatoma cell line Hepa-1 was shown to express an aldehyde dehydrogenase (ALDH) isozyme which was inducible by TCDD and carcinogenic polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 143-175 aldehyde dehydrogenase family 3, subfamily A1 Mus musculus 60-82 1505055-1 1992 The mouse hepatoma cell line Hepa-1 was shown to express an aldehyde dehydrogenase (ALDH) isozyme which was inducible by TCDD and carcinogenic polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 143-175 aldehyde dehydrogenase family 3, subfamily A1 Mus musculus 84-88 1504257-4 1992 Anodic peak potentials (Eap) of 90 PAH were measured by cyclic voltammetry under irreversible oxidation conditions and correlated with the corresponding IP. Polycyclic Aromatic Hydrocarbons 35-38 glutamyl aminopeptidase Homo sapiens 24-27 1391625-0 1992 Examination of diols and diol epoxides of polycyclic aromatic hydrocarbons as substrates for rat liver dihydrodiol dehydrogenase. Polycyclic Aromatic Hydrocarbons 42-74 dihydrodiol dehydrogenase Rattus norvegicus 103-128 1391625-1 1992 Dihydrodiol dehydrogenase (DD; EC 1.3.1.20) can suppress the formation of anti-diol epoxides that arise from the metabolic activation of PAH by oxidizing their precursor trans-dihydrodiols to o-quinones [Smithgall, T.E., et al. Polycyclic Aromatic Hydrocarbons 137-140 dihydrodiol dehydrogenase Rattus norvegicus 0-25 1317062-1 1992 The Ah (dioxin) receptor binds a number of widely disseminated environmental pollutants, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons, and mediates their carcinogenic effects. Polycyclic Aromatic Hydrocarbons 146-178 aryl hydrocarbon receptor Homo sapiens 4-24 1588920-13 1992 Thus, this work clearly shows that human lung microsomes contain at least two major P-450 enzymes; human P-450 1A1 is present in lungs and can actually catalyze the activation of environmental procarcinogens, including polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 219-251 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 84-89 1588920-13 1992 Thus, this work clearly shows that human lung microsomes contain at least two major P-450 enzymes; human P-450 1A1 is present in lungs and can actually catalyze the activation of environmental procarcinogens, including polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 219-251 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 105-110 1536575-10 1992 An unexpected finding was the presence at position -403 to -385 of a putative dioxin responsive element, a sequence found to be responsible for the induction of transcription of the cytochrome P450IA1 gene (CYPIA1) and other genes involved in detoxification/activation of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 272-304 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 207-213 1564251-2 1992 To see if this might be linked to exposure to polycyclic aromatic hydrocarbons (PAHs) contained in refinery streams, a review of animal data on the relationship between PAH exposure, UV light and melanoma induction has been carried out and compared with human data. Polycyclic Aromatic Hydrocarbons 46-78 phenylalanine hydroxylase Homo sapiens 80-83 1744743-2 1991 Polycyclic aromatic hydrocarbons are important respiratory carcinogens and have been shown to cause specific mutational lesions that can lead to the activation of the ras oncogene and expression of its p21 protein product; ras oncogene activation and p21 expression frequently are detected in human lung cancers. Polycyclic Aromatic Hydrocarbons 0-32 H3 histone pseudogene 16 Homo sapiens 202-205 1316759-2 1992 AHH is an inducile enzyme activity known to play an important role in the bioactivation of polycyclic aromatic hydrocarbons (PAHs) to mutagenic and carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 91-123 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 0-3 1316759-2 1992 AHH is an inducile enzyme activity known to play an important role in the bioactivation of polycyclic aromatic hydrocarbons (PAHs) to mutagenic and carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 125-129 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 0-3 1316759-3 1992 PAH-induced expression of the CYP1A1 gene appears to be regulated by several trans-acting factors, including the Ah receptor and the 4S PAH-binding protein. Polycyclic Aromatic Hydrocarbons 0-3 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 30-36 1316759-3 1992 PAH-induced expression of the CYP1A1 gene appears to be regulated by several trans-acting factors, including the Ah receptor and the 4S PAH-binding protein. Polycyclic Aromatic Hydrocarbons 0-3 aryl hydrocarbon receptor Rattus norvegicus 113-124 1316759-4 1992 In this study, we used the PAH isomers benzo[a]pyrene (BaP) and benzo[e]pyrene (BeP) to further evaluate the role of the 4S PAH-binding protein in induction of the CYP1A1 gene in H4-II-E rat hepatoma cells. Polycyclic Aromatic Hydrocarbons 124-127 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 164-170 1316759-10 1992 These results suggest that the 4S protein may play a role in the PAH-induced expression of the CYP1A1 gene in rat H4-II-E cells. Polycyclic Aromatic Hydrocarbons 65-68 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 95-101 1503641-1 1992 During two-stage mouse skin tumorigenesis, the mouse c-Ha-ras oncogene undergoes activation by point mutation after initiation with polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 132-164 Harvey rat sarcoma virus oncogene Mus musculus 53-61 1289900-3 1992 Cytochrome P450 mediates binding of PAH to DNA by two pathways of activation. Polycyclic Aromatic Hydrocarbons 36-39 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-15 1306334-3 1992 Different P450 forms are responsible for activation of the various classes of chemical carcinogens including the arylamines, polycyclic aromatic hydrocarbons, nitrosamines and aflatoxins. Polycyclic Aromatic Hydrocarbons 125-157 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 10-14 1754392-1 1991 Cyp1a-1, whose product, aryl hydrocarbon hydroxylase, assists in detoxification of polycyclic aromatic hydrocarbons, is the best characterized of the murine cytochrome P450 genes. Polycyclic Aromatic Hydrocarbons 83-115 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-7 1658612-1 1991 The aromatic hydrocarbon (Ah) receptor mediates induction of cytochrome P4501A1 and associated aryl hydrocarbon hydroxylase (AHH) activity in tissues or cells exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 170-202 aryl-hydrocarbon receptor Mus musculus 4-38 1658612-1 1991 The aromatic hydrocarbon (Ah) receptor mediates induction of cytochrome P4501A1 and associated aryl hydrocarbon hydroxylase (AHH) activity in tissues or cells exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 170-202 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 61-79 1658612-1 1991 The aromatic hydrocarbon (Ah) receptor mediates induction of cytochrome P4501A1 and associated aryl hydrocarbon hydroxylase (AHH) activity in tissues or cells exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 170-202 aryl-hydrocarbon receptor Mus musculus 95-123 1658612-1 1991 The aromatic hydrocarbon (Ah) receptor mediates induction of cytochrome P4501A1 and associated aryl hydrocarbon hydroxylase (AHH) activity in tissues or cells exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 170-202 aryl-hydrocarbon receptor Mus musculus 125-128 1654865-1 1991 The Ah (aromatic hydrocarbon) receptor mediates induction of aryl hydrocarbon hydroxylase (AHH; an enzyme activity associated with cytochrome P450IA1) by polycyclic aromatic hydrocarbon carcinogens such as 3-methylcholanthrene (MC) and benzo[a]pyrene (BP) and the halogenated toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polycyclic Aromatic Hydrocarbons 154-185 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 61-89 1654865-1 1991 The Ah (aromatic hydrocarbon) receptor mediates induction of aryl hydrocarbon hydroxylase (AHH; an enzyme activity associated with cytochrome P450IA1) by polycyclic aromatic hydrocarbon carcinogens such as 3-methylcholanthrene (MC) and benzo[a]pyrene (BP) and the halogenated toxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polycyclic Aromatic Hydrocarbons 154-185 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 91-94 1744743-2 1991 Polycyclic aromatic hydrocarbons are important respiratory carcinogens and have been shown to cause specific mutational lesions that can lead to the activation of the ras oncogene and expression of its p21 protein product; ras oncogene activation and p21 expression frequently are detected in human lung cancers. Polycyclic Aromatic Hydrocarbons 0-32 H3 histone pseudogene 16 Homo sapiens 251-254 1714456-2 1991 3-alpha-Hydroxysteroid dehydrogenase (3 alpha-HSD) (EC 1.1.1.50) is an important multifunctional oxidoreductase capable of metabolizing steroid hormones, polycyclic aromatic hydrocarbons, and prostaglandins. Polycyclic Aromatic Hydrocarbons 154-186 aldo-keto reductase family 1, member C14 Rattus norvegicus 0-36 1714456-2 1991 3-alpha-Hydroxysteroid dehydrogenase (3 alpha-HSD) (EC 1.1.1.50) is an important multifunctional oxidoreductase capable of metabolizing steroid hormones, polycyclic aromatic hydrocarbons, and prostaglandins. Polycyclic Aromatic Hydrocarbons 154-186 aldo-keto reductase family 1, member C14 Rattus norvegicus 38-49 1910027-11 1991 Our observations suggest that induction of AHH after treatment with polycyclic aromatic hydrocarbon is dependent on proline-related metabolism which influences the transcriptional process of P(1)450 gene expression. Polycyclic Aromatic Hydrocarbons 68-99 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 43-46 1849670-1 1991 The 4 S polycyclic aromatic hydrocarbon (PAH)-binding protein had been implicated in regulating the expression of rat cytochrome P450IA1 which is most closely associated with aryl hydrocarbon hydroxylase (AHH). Polycyclic Aromatic Hydrocarbons 8-39 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 175-203 1708245-6 1991 This appears to be the optimal time to study changes in the levels of CYPIA1 RNA gene expression in the fetus following transplacental exposure to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 147-179 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 70-76 1736417-1 1992 Induction of aryl hydrocarbon hydroxylase (AHH) activity in the placenta as a result of maternal exposure to polycyclic aromatic hydrocarbons contained in cigarette smoke has been well documented. Polycyclic Aromatic Hydrocarbons 109-141 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 13-41 1736417-1 1992 Induction of aryl hydrocarbon hydroxylase (AHH) activity in the placenta as a result of maternal exposure to polycyclic aromatic hydrocarbons contained in cigarette smoke has been well documented. Polycyclic Aromatic Hydrocarbons 109-141 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 43-46 1852076-1 1991 The aryl hydrocarbon (Ah) receptor binds various environmental pollutants, such as polycyclic aromatic hydrocarbons, heterocyclic amines, and polychlorinated aromatic compounds (dioxins, dibenzofurans, and biphenyls), and mediates the carcinogenic effects of these agents. Polycyclic Aromatic Hydrocarbons 83-115 aryl hydrocarbon receptor Homo sapiens 4-34 1849670-1 1991 The 4 S polycyclic aromatic hydrocarbon (PAH)-binding protein had been implicated in regulating the expression of rat cytochrome P450IA1 which is most closely associated with aryl hydrocarbon hydroxylase (AHH). Polycyclic Aromatic Hydrocarbons 8-39 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 205-208 1849670-1 1991 The 4 S polycyclic aromatic hydrocarbon (PAH)-binding protein had been implicated in regulating the expression of rat cytochrome P450IA1 which is most closely associated with aryl hydrocarbon hydroxylase (AHH). Polycyclic Aromatic Hydrocarbons 41-44 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 175-203 1849670-1 1991 The 4 S polycyclic aromatic hydrocarbon (PAH)-binding protein had been implicated in regulating the expression of rat cytochrome P450IA1 which is most closely associated with aryl hydrocarbon hydroxylase (AHH). Polycyclic Aromatic Hydrocarbons 41-44 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 205-208 1913972-8 1991 Evidence is presented which supports a role for PHS in the bioactivation of several polycyclic aromatic hydrocarbons and aromatic amines, two classes of carcinogens which induce extrahepatic neoplasia. Polycyclic Aromatic Hydrocarbons 84-116 pterin-4 alpha-carbinolamine dehydratase 1 Homo sapiens 48-51 1851644-1 1991 The Ah receptor is a soluble protein complex that mediates carcinogenesis by a wide range of environmental pollutants, including polycyclic aromatic hydrocarbons, heterocyclic amines, and polychlorinated aromatic compounds. Polycyclic Aromatic Hydrocarbons 129-161 aryl hydrocarbon receptor Homo sapiens 4-15 2171791-9 1990 The results suggest that the synergistic effect of DEX and polycyclic aromatic hydrocarbons on P450IA1 induction involves a time-consuming process which may consist of the synthesis or modification of a factor, possibly the Ah receptor. Polycyclic Aromatic Hydrocarbons 59-91 aryl hydrocarbon receptor Rattus norvegicus 224-235 2060039-5 1991 On the contrary, polycyclic aromatic hydrocarbons, polychlorinated biphenyls (Arochlor 1254) and 2-naphthylamine produced a remarkable increase of ALDH. Polycyclic Aromatic Hydrocarbons 17-49 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 147-151 1914494-1 1991 UDP-glucuronosyltransferases (UGT) play a major role in the elimination of nucleophilic metabolites of carcinogens, such as phenols and quinols of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 147-179 beta-1,3-glucuronyltransferase 2 Homo sapiens 0-28 1914494-1 1991 UDP-glucuronosyltransferases (UGT) play a major role in the elimination of nucleophilic metabolites of carcinogens, such as phenols and quinols of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 147-179 beta-1,3-glucuronyltransferase 2 Homo sapiens 30-33 2113322-1 1990 The effects of in vivo administration of polycyclic aromatic hydrocarbons on the levels of aryl hydrocarbon hydroxylase (AHH) activity in aromatic hydrocarbon (Ah) responsive and non-responsive strains of mice were studied using the hepatic microsomal fraction. Polycyclic Aromatic Hydrocarbons 41-73 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 91-119 2113322-1 1990 The effects of in vivo administration of polycyclic aromatic hydrocarbons on the levels of aryl hydrocarbon hydroxylase (AHH) activity in aromatic hydrocarbon (Ah) responsive and non-responsive strains of mice were studied using the hepatic microsomal fraction. Polycyclic Aromatic Hydrocarbons 41-73 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 121-124 2235714-1 1990 Aromatic hydrocarbons hydroxylase (AHH)--an enzyme of monooxydases group--catalyzes hydroxylation of polycyclic aromatic hydrocarbons yielding compounds of the direct cancerogenic properties. Polycyclic Aromatic Hydrocarbons 101-133 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-33 2235714-1 1990 Aromatic hydrocarbons hydroxylase (AHH)--an enzyme of monooxydases group--catalyzes hydroxylation of polycyclic aromatic hydrocarbons yielding compounds of the direct cancerogenic properties. Polycyclic Aromatic Hydrocarbons 101-133 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 35-38 2235714-5 1990 A significant increase in the incidence of neoplasms related to an exposition to PAH was noted in patients with increased AHH inducibility. Polycyclic Aromatic Hydrocarbons 81-84 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 122-125 2343183-5 1990 The addition of azide, CuDIPS, or taurine markedly inhibited the induction of SCEs by the combination of BP-7,8-diol and stimulated PMNs, further suggesting the involvement of myeloperoxidase in the activation of the polycyclic aromatic hydrocarbon. Polycyclic Aromatic Hydrocarbons 217-248 myeloperoxidase Homo sapiens 176-191 2154949-10 1990 Aryl hydrocarbon hydroxylase (AHH) activity was significantly induced after 24 h of incubation with polycyclic aromatic hydrocarbons: the EC50 for AHH induction was 5.3 microM for benz(a)anthracene and 1.3 microM for 3-methylcholanthrene. Polycyclic Aromatic Hydrocarbons 100-132 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-28 2154949-10 1990 Aryl hydrocarbon hydroxylase (AHH) activity was significantly induced after 24 h of incubation with polycyclic aromatic hydrocarbons: the EC50 for AHH induction was 5.3 microM for benz(a)anthracene and 1.3 microM for 3-methylcholanthrene. Polycyclic Aromatic Hydrocarbons 100-132 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 30-33 2154949-10 1990 Aryl hydrocarbon hydroxylase (AHH) activity was significantly induced after 24 h of incubation with polycyclic aromatic hydrocarbons: the EC50 for AHH induction was 5.3 microM for benz(a)anthracene and 1.3 microM for 3-methylcholanthrene. Polycyclic Aromatic Hydrocarbons 100-132 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 147-150 2299644-2 1990 The PBP binds polycyclic aromatic hydrocarbons, such as benzo[a]pyrene (B[a]P), with high affinity and shows other characteristics associated with receptor-ligand complexes. Polycyclic Aromatic Hydrocarbons 14-46 phosphatidylethanolamine binding protein 1 Mus musculus 4-7 2304451-0 1990 Glucocorticoid regulation of polycyclic aromatic hydrocarbon induction of cytochrome P450IA1, glutathione S-transferases, and NAD(P)H:quinone oxidoreductase in cultured fetal rat hepatocytes. Polycyclic Aromatic Hydrocarbons 29-60 crystallin zeta Rattus norvegicus 134-156 2304451-6 1990 Both the induction of glutathione S-transferase activity by high concentrations of dexamethasone alone and the potentiation of 1,2-benzanthracene induction by lower concentrations of dexamethasone were observed for other steroids of the glucocorticoid class in conjunction with a variety of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 291-323 hematopoietic prostaglandin D synthase Rattus norvegicus 22-47 2304451-9 1990 Potentiation of polycyclic aromatic hydrocarbon induction of cytochrome P450IA1, glutathione S-transferase, and NAD(P)H:quinone oxidoreductase protein content by low concentrations of glucocorticoids and induction of glutathione S-transferase and NAD(P)H:quinone oxidoreductase by high concentrations of glucocorticoids alone indicates the importance of these endogenous compounds in the regulation of some hepatic enzymes involved in xenobiotic metabolism. Polycyclic Aromatic Hydrocarbons 16-47 hematopoietic prostaglandin D synthase Rattus norvegicus 81-106 2304451-9 1990 Potentiation of polycyclic aromatic hydrocarbon induction of cytochrome P450IA1, glutathione S-transferase, and NAD(P)H:quinone oxidoreductase protein content by low concentrations of glucocorticoids and induction of glutathione S-transferase and NAD(P)H:quinone oxidoreductase by high concentrations of glucocorticoids alone indicates the importance of these endogenous compounds in the regulation of some hepatic enzymes involved in xenobiotic metabolism. Polycyclic Aromatic Hydrocarbons 16-47 crystallin zeta Rattus norvegicus 120-142 2304451-9 1990 Potentiation of polycyclic aromatic hydrocarbon induction of cytochrome P450IA1, glutathione S-transferase, and NAD(P)H:quinone oxidoreductase protein content by low concentrations of glucocorticoids and induction of glutathione S-transferase and NAD(P)H:quinone oxidoreductase by high concentrations of glucocorticoids alone indicates the importance of these endogenous compounds in the regulation of some hepatic enzymes involved in xenobiotic metabolism. Polycyclic Aromatic Hydrocarbons 16-47 hematopoietic prostaglandin D synthase Rattus norvegicus 217-242 2304451-9 1990 Potentiation of polycyclic aromatic hydrocarbon induction of cytochrome P450IA1, glutathione S-transferase, and NAD(P)H:quinone oxidoreductase protein content by low concentrations of glucocorticoids and induction of glutathione S-transferase and NAD(P)H:quinone oxidoreductase by high concentrations of glucocorticoids alone indicates the importance of these endogenous compounds in the regulation of some hepatic enzymes involved in xenobiotic metabolism. Polycyclic Aromatic Hydrocarbons 16-47 crystallin zeta Rattus norvegicus 255-277 2208597-15 1990 The results of our experiments demonstrate localization of the PBP to sites of active physiological response to PAH exposure. Polycyclic Aromatic Hydrocarbons 112-115 phosphatidylethanolamine binding protein 1 Mus musculus 63-66 2380990-1 1990 The major polycyclic aromatic hydrocarbon inducible-cytochrome P4501A1 gene (CYP1A1) is presumed to be important in pulmonary carcinogenesis and toxicology because its product, the cytochrome P4501A1-dependent (CYP1A1-dependent) monooxygenase, transforms selected xenobiotics (including polycyclic aromatic hydrocarbon procarcinogens in cigarette smoke) to potent carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 10-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 52-70 2380990-1 1990 The major polycyclic aromatic hydrocarbon inducible-cytochrome P4501A1 gene (CYP1A1) is presumed to be important in pulmonary carcinogenesis and toxicology because its product, the cytochrome P4501A1-dependent (CYP1A1-dependent) monooxygenase, transforms selected xenobiotics (including polycyclic aromatic hydrocarbon procarcinogens in cigarette smoke) to potent carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 10-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 77-83 2380990-1 1990 The major polycyclic aromatic hydrocarbon inducible-cytochrome P4501A1 gene (CYP1A1) is presumed to be important in pulmonary carcinogenesis and toxicology because its product, the cytochrome P4501A1-dependent (CYP1A1-dependent) monooxygenase, transforms selected xenobiotics (including polycyclic aromatic hydrocarbon procarcinogens in cigarette smoke) to potent carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 10-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 181-199 2380990-1 1990 The major polycyclic aromatic hydrocarbon inducible-cytochrome P4501A1 gene (CYP1A1) is presumed to be important in pulmonary carcinogenesis and toxicology because its product, the cytochrome P4501A1-dependent (CYP1A1-dependent) monooxygenase, transforms selected xenobiotics (including polycyclic aromatic hydrocarbon procarcinogens in cigarette smoke) to potent carcinogenic metabolites. Polycyclic Aromatic Hydrocarbons 10-41 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 211-217 2379146-6 1990 These results indicate that the PAH-metabolizing monooxygenase(s) in these endocrine organs may involve a novel form(s) of cytochrome P-450. Polycyclic Aromatic Hydrocarbons 32-35 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 123-139 2372865-4 1990 In contrast, polycyclic aromatic hydrocarbons, such as 3-methylcholanthrene, benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene, induce an immediate increase of T-ALDH activity in both cultured rat hepatocytes and hepatoma cell lines. Polycyclic Aromatic Hydrocarbons 13-45 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 162-166 2372874-1 1990 The polycyclic aromatic hydrocarbon (PAH)-induced expression of the rat Cyp1A1 gene is a complex process which appears to be regulated by several trans-acting factors including the 8S (Ah receptor) and 4S PAH binding proteins. Polycyclic Aromatic Hydrocarbons 4-35 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 72-78 2372874-1 1990 The polycyclic aromatic hydrocarbon (PAH)-induced expression of the rat Cyp1A1 gene is a complex process which appears to be regulated by several trans-acting factors including the 8S (Ah receptor) and 4S PAH binding proteins. Polycyclic Aromatic Hydrocarbons 4-35 aryl hydrocarbon receptor Rattus norvegicus 185-196 2372874-1 1990 The polycyclic aromatic hydrocarbon (PAH)-induced expression of the rat Cyp1A1 gene is a complex process which appears to be regulated by several trans-acting factors including the 8S (Ah receptor) and 4S PAH binding proteins. Polycyclic Aromatic Hydrocarbons 37-40 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 72-78 2372874-1 1990 The polycyclic aromatic hydrocarbon (PAH)-induced expression of the rat Cyp1A1 gene is a complex process which appears to be regulated by several trans-acting factors including the 8S (Ah receptor) and 4S PAH binding proteins. Polycyclic Aromatic Hydrocarbons 37-40 aryl hydrocarbon receptor Rattus norvegicus 185-196 2372874-1 1990 The polycyclic aromatic hydrocarbon (PAH)-induced expression of the rat Cyp1A1 gene is a complex process which appears to be regulated by several trans-acting factors including the 8S (Ah receptor) and 4S PAH binding proteins. Polycyclic Aromatic Hydrocarbons 205-208 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 72-78 2372874-2 1990 This gene is closely associated with aryl hydrocarbon hydroxylase enzyme activity (AHH), which is known to bioactivate PAHs. Polycyclic Aromatic Hydrocarbons 119-123 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 83-86 2307152-8 1990 When co-cultivated with Chinese hamster V-79 cells in the presence of PAH, both rat and human MEC can activate and release the active metabolites to induce SCE in V-79 cells. Polycyclic Aromatic Hydrocarbons 70-73 C-C motif chemokine ligand 28 Homo sapiens 94-97 2157855-2 1990 At least two distinct high-affinity binding proteins may regulate its expression, the 4S protein that primarily binds polycyclic aromatic hydrocarbons (PAHs), and the 8S Ah receptor that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and like congeners. Polycyclic Aromatic Hydrocarbons 118-150 aryl hydrocarbon receptor Rattus norvegicus 170-181 2157855-2 1990 At least two distinct high-affinity binding proteins may regulate its expression, the 4S protein that primarily binds polycyclic aromatic hydrocarbons (PAHs), and the 8S Ah receptor that binds 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and like congeners. Polycyclic Aromatic Hydrocarbons 152-156 aryl hydrocarbon receptor Rattus norvegicus 170-181 34392205-1 2021 Pyrene is a model contaminant of high molecular weight polycyclic aromatic hydrocarbons (HMW-PAHs), which are compounds that have potential carcinogenic effects and pose a serious threat to human health. Polycyclic Aromatic Hydrocarbons 55-87 cilia and flagella associated protein 97 Homo sapiens 89-92 33233810-6 2020 On the other hand, AhR activation by particle-associated polycyclic aromatic hydrocarbons from the environment is pro-inflammatory, inducing mucus hypersecretion, airway remodelling, dysregulation of antigen presenting cells and exacerbates asthma features. Polycyclic Aromatic Hydrocarbons 57-89 aryl-hydrocarbon receptor Mus musculus 19-22 26122708-3 2015 Activation of Nrf2 can, however, serve as a double-edged sword because some of the genes it induces may contribute to chemical carcinogenesis by promoting futile redox cycling of polycyclic aromatic hydrocarbon metabolites or confer resistance to chemotherapeutic drugs by increasing the expression of efflux pumps, suggesting its cytoprotective effects will vary in a context-specific fashion. Polycyclic Aromatic Hydrocarbons 179-210 NFE2 like bZIP transcription factor 2 Homo sapiens 14-18 19326037-10 2009 Strong correlations were found between PAH and PCB concentrations and soil organic matter and, also, between PAH and PCB concentrations. Polycyclic Aromatic Hydrocarbons 39-42 pyruvate carboxylase Homo sapiens 47-50 19326037-10 2009 Strong correlations were found between PAH and PCB concentrations and soil organic matter and, also, between PAH and PCB concentrations. Polycyclic Aromatic Hydrocarbons 109-112 pyruvate carboxylase Homo sapiens 117-120 1378179-4 1992 The efficiencies of XAD-2 and C18 resins for concentrating PAH urinary mutagens were evaluated in the microsuspension assay. Polycyclic Aromatic Hydrocarbons 59-62 Bardet-Biedl syndrome 9 Homo sapiens 30-33 34742985-0 2022 Prediction of the gas/particle partitioning quotient of PAHs based on ambient temperature. Polycyclic Aromatic Hydrocarbons 56-60 gastrin Homo sapiens 18-21 34823955-8 2022 Our findings demonstrated that long-term high levels of PAHs exposure could cause HRV reductions, and TGF-beta1 may play an essential role in such association. Polycyclic Aromatic Hydrocarbons 56-60 transforming growth factor beta 1 Homo sapiens 102-111 34929281-10 2022 CYP1A1 and CYP1B1 adverse polymorphisms, familial BC history and smoking status, significantly strengthened the association between PAHs exposure and BC, whereas high fruit and vegetable intake had antagonistic associations. Polycyclic Aromatic Hydrocarbons 132-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 34929281-10 2022 CYP1A1 and CYP1B1 adverse polymorphisms, familial BC history and smoking status, significantly strengthened the association between PAHs exposure and BC, whereas high fruit and vegetable intake had antagonistic associations. Polycyclic Aromatic Hydrocarbons 132-136 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 11-17 34818808-4 2022 To address this knowledge gap, pyrene was used as a model compound to investigate the biodegradation of polycyclic aromatic hydrocarbon on montmorillonite mineral saturated with metal ions (Na(I), Ni(II), Co(II), Cu(II) and Fe(III)) by Mycobacteria strain NJS-1. Polycyclic Aromatic Hydrocarbons 104-135 mitochondrially encoded cytochrome c oxidase II Homo sapiens 205-211 34883356-3 2022 Compared with Sil@ODNVP, both of Sil@ODVIm and Sil@ODVPy had smaller peak width and higher column efficiency in the separation of 10 polycyclic aromatic hydrocarbons (PAHs), 7 alkyl benzenes, 7 aromatic acids, 7 aromatic esters and 9 phenols. Polycyclic Aromatic Hydrocarbons 133-165 STIL centriolar assembly protein Homo sapiens 33-36 34883356-3 2022 Compared with Sil@ODNVP, both of Sil@ODVIm and Sil@ODVPy had smaller peak width and higher column efficiency in the separation of 10 polycyclic aromatic hydrocarbons (PAHs), 7 alkyl benzenes, 7 aromatic acids, 7 aromatic esters and 9 phenols. Polycyclic Aromatic Hydrocarbons 133-165 STIL centriolar assembly protein Homo sapiens 47-50 34883356-3 2022 Compared with Sil@ODNVP, both of Sil@ODVIm and Sil@ODVPy had smaller peak width and higher column efficiency in the separation of 10 polycyclic aromatic hydrocarbons (PAHs), 7 alkyl benzenes, 7 aromatic acids, 7 aromatic esters and 9 phenols. Polycyclic Aromatic Hydrocarbons 167-171 STIL centriolar assembly protein Homo sapiens 33-36 34883356-3 2022 Compared with Sil@ODNVP, both of Sil@ODVIm and Sil@ODVPy had smaller peak width and higher column efficiency in the separation of 10 polycyclic aromatic hydrocarbons (PAHs), 7 alkyl benzenes, 7 aromatic acids, 7 aromatic esters and 9 phenols. Polycyclic Aromatic Hydrocarbons 167-171 STIL centriolar assembly protein Homo sapiens 47-50 34351578-7 2022 Heterogeneous effects of occupational PAH exposure were observed among carriers of AKR1C3/4 variants, as well as the PTGS2 variant rs5275. Polycyclic Aromatic Hydrocarbons 38-41 aldo-keto reductase family 1 member C3 Homo sapiens 83-91 34492419-8 2022 RH contained the least bioavailable and leachable PAHs concentration and phytotoxicity compared with CS and PS, which might attribute to the characteristic of three biochars. Polycyclic Aromatic Hydrocarbons 50-54 citrate synthase Homo sapiens 101-103 34492419-9 2022 CS and PS were acidic and exhibited high levels of DOC and VFAs, while RH was strongly alkaline and presented greater aromaticity and higher surface area, which might have resulted in high adsorptive capacity and decreased bioavailability of PAHs. Polycyclic Aromatic Hydrocarbons 242-246 citrate synthase Homo sapiens 0-2 34991250-1 2022 Polycyclic aromatic hydrocarbons (PAHs), dioxin-like compounds (DLCs) and structurally-related environmental pollutants may contribute to the pathogenesis of various diseases and disorders, primarily by activating the aryl hydrocarbon receptor (AHR) and modulating downstream cellular responses. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 218-243 34991250-1 2022 Polycyclic aromatic hydrocarbons (PAHs), dioxin-like compounds (DLCs) and structurally-related environmental pollutants may contribute to the pathogenesis of various diseases and disorders, primarily by activating the aryl hydrocarbon receptor (AHR) and modulating downstream cellular responses. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 245-248 34991250-1 2022 Polycyclic aromatic hydrocarbons (PAHs), dioxin-like compounds (DLCs) and structurally-related environmental pollutants may contribute to the pathogenesis of various diseases and disorders, primarily by activating the aryl hydrocarbon receptor (AHR) and modulating downstream cellular responses. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 218-243 34991250-1 2022 Polycyclic aromatic hydrocarbons (PAHs), dioxin-like compounds (DLCs) and structurally-related environmental pollutants may contribute to the pathogenesis of various diseases and disorders, primarily by activating the aryl hydrocarbon receptor (AHR) and modulating downstream cellular responses. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 245-248 34871918-4 2022 The PAH fraction was directly injected into an online gel permeation chromatography-gas chromatography-triple quadrupole tandem mass spectrometry (GPC-GC-MS/MS) system, enabling rapid determination of 16 PAHs. Polycyclic Aromatic Hydrocarbons 4-7 glycophorin C (Gerbich blood group) Homo sapiens 147-150 34755446-2 2022 This work introduces a highly efficient, regenerable membrane for the removal of PAHs from water, featuring excellent filter performance and pH-driven release, thanks to the integration of a cavitand receptor in electrospun polyacrylonitrile (PAN) fibers. Polycyclic Aromatic Hydrocarbons 81-85 phenylalanine hydroxylase Homo sapiens 141-143 34755446-7 2022 The regeneration of the membrane is performed by exploiting the pH-driven conformational switching of the cavitand between the vase form, where the PAHs uptake takes place, to the kite one, where the PAHs release occurs. Polycyclic Aromatic Hydrocarbons 148-152 phenylalanine hydroxylase Homo sapiens 64-66 34879859-0 2021 PIG-A gene mutation as a genotoxicity biomaker in polycyclic aromatic hydrocarbon-exposed barbecue workers. Polycyclic Aromatic Hydrocarbons 50-81 phosphatidylinositol glycan anchor biosynthesis class A Sus scrofa 0-5 34879859-3 2021 METHODS: We investigated the genotoxic effect of red blood cells using PIG-A assay and lymphocyte cytokinesis-block micronucleus test in barbecue restaurant workers (N = 70) exposed to polycyclic aromatic hydrocarbons (PAHs) and self-identified healthy control subjects (N = 56). Polycyclic Aromatic Hydrocarbons 185-217 phosphatidylinositol glycan anchor biosynthesis class A Sus scrofa 71-76 34879859-5 2021 RESULTS: Multivariate Poisson regression showed that the PAH-exposed workers exhibited significantly higher PIG-A mutant frequency (MF) (8.04 +- 6.81 x 10- 6) than did the controls (5.56 +- 5.26 x 10- 6) (RR = 0.707, 95% CI: 0.615-0.812, P < 0.001). Polycyclic Aromatic Hydrocarbons 57-60 phosphatidylinositol glycan anchor biosynthesis class A Sus scrofa 108-113 34879859-6 2021 These results indicate that PAH exposure is a risk factor for elevated PIG-A MF. Polycyclic Aromatic Hydrocarbons 28-31 phosphatidylinositol glycan anchor biosynthesis class A Sus scrofa 71-76 34879859-10 2021 Furthermore, there was a significant association between PIG-A MF and PAH exposure levels (Chi-square test for trend, P = 0.006). Polycyclic Aromatic Hydrocarbons 70-73 phosphatidylinositol glycan anchor biosynthesis class A Sus scrofa 57-62 34879859-11 2021 CONCLUSIONS: Our results indicate that an increase in PIG-A MF in barbecue workers could reflect the response to PAH exposure, providing evidence of its potential as a genotoxicity biomarker in human risk assessment. Polycyclic Aromatic Hydrocarbons 113-116 phosphatidylinositol glycan anchor biosynthesis class A Sus scrofa 54-59 34523522-0 2021 Associations of polycyclic aromatic hydrocarbons exposure and its interaction with XRCC1 genetic polymorphism with lung cancer: A case-control study. Polycyclic Aromatic Hydrocarbons 16-48 X-ray repair cross complementing 1 Homo sapiens 83-88 34727194-0 2021 Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant. Polycyclic Aromatic Hydrocarbons 60-91 ETS transcription factor ERG Homo sapiens 18-22 34416499-6 2021 The median PAH concentration in serum was 4.05 ng mL-1, which was lower than that of OH-PAHs in urine (8.33 ng mL-1). Polycyclic Aromatic Hydrocarbons 11-14 L1 cell adhesion molecule Mus musculus 50-54 34657897-10 2021 From the gas-particle partitioning ratio of 16 polycyclic aromatic hydrocarbons (PAHs) in a coal tar pitch manufacturing industry, the underestimation of the concentration of semi-volatile matters using the gas collection tubes has been discussed. Polycyclic Aromatic Hydrocarbons 47-79 gastrin Homo sapiens 9-12 34794034-12 2021 Totally, prenatal PAHs exposures may contribute to an increased risk of LBW of their infants by modulating the DNA methylation states of genomic DNA and growth-related genes (IGF1 and IGF2) in the umbilical cord blood, which could provide the prenatal prevention of PAHs exposure from possible environmental media except from the occupation and tobacco usage to ensure the health of their infants. Polycyclic Aromatic Hydrocarbons 18-22 insulin like growth factor 1 Homo sapiens 175-179 34794034-12 2021 Totally, prenatal PAHs exposures may contribute to an increased risk of LBW of their infants by modulating the DNA methylation states of genomic DNA and growth-related genes (IGF1 and IGF2) in the umbilical cord blood, which could provide the prenatal prevention of PAHs exposure from possible environmental media except from the occupation and tobacco usage to ensure the health of their infants. Polycyclic Aromatic Hydrocarbons 18-22 insulin like growth factor 2 Homo sapiens 184-188 34664048-0 2021 Aggregation effects on photophysical properties of NBN-doped polycyclic aromatic hydrocarbons: a theoretical study. Polycyclic Aromatic Hydrocarbons 61-93 nibrin Homo sapiens 51-54 34537657-3 2021 This C18-CDs decorated silica column showed good separation performance for polycyclic aromatic hydrocarbons and alkylbenzenes under RPLC mode. Polycyclic Aromatic Hydrocarbons 76-108 Bardet-Biedl syndrome 9 Homo sapiens 5-8 34333383-0 2021 Genetic variants in telomerase-associated protein 1 are associated with telomere damage in PAH-exposed workers. Polycyclic Aromatic Hydrocarbons 91-94 telomerase associated protein 1 Homo sapiens 20-51 34333383-5 2021 However, it is unknown whether genetic variants in the TEP1 gene may affect telomere length (TL) in polycyclic aromatic hydrocarbon (PAH)-exposed workers. Polycyclic Aromatic Hydrocarbons 133-136 telomerase associated protein 1 Homo sapiens 55-59 34164787-0 2021 The interaction effects of FEN1 rs174538 polymorphism and polycyclic aromatic hydrocarbon exposure on damage in exon 19 and 21 of EGFR gene in coke oven workers. Polycyclic Aromatic Hydrocarbons 58-89 epidermal growth factor receptor Homo sapiens 130-134 34164787-2 2021 We aimed to explore the dose-effect associations of PAH exposure with damage of exons of epidermal growth factor receptor (EGFR) and breast cancer susceptibility gene 1 (BRCA1), as well as their associations whether modified by Flap endonuclease 1 (FEN1) genotype. Polycyclic Aromatic Hydrocarbons 52-55 epidermal growth factor receptor Homo sapiens 89-121 34164787-2 2021 We aimed to explore the dose-effect associations of PAH exposure with damage of exons of epidermal growth factor receptor (EGFR) and breast cancer susceptibility gene 1 (BRCA1), as well as their associations whether modified by Flap endonuclease 1 (FEN1) genotype. Polycyclic Aromatic Hydrocarbons 52-55 epidermal growth factor receptor Homo sapiens 123-127 34164787-2 2021 We aimed to explore the dose-effect associations of PAH exposure with damage of exons of epidermal growth factor receptor (EGFR) and breast cancer susceptibility gene 1 (BRCA1), as well as their associations whether modified by Flap endonuclease 1 (FEN1) genotype. Polycyclic Aromatic Hydrocarbons 52-55 BRCA1 DNA repair associated Homo sapiens 170-175 34164787-2 2021 We aimed to explore the dose-effect associations of PAH exposure with damage of exons of epidermal growth factor receptor (EGFR) and breast cancer susceptibility gene 1 (BRCA1), as well as their associations whether modified by Flap endonuclease 1 (FEN1) genotype. Polycyclic Aromatic Hydrocarbons 52-55 flap structure-specific endonuclease 1 Homo sapiens 228-247 34164787-2 2021 We aimed to explore the dose-effect associations of PAH exposure with damage of exons of epidermal growth factor receptor (EGFR) and breast cancer susceptibility gene 1 (BRCA1), as well as their associations whether modified by Flap endonuclease 1 (FEN1) genotype. Polycyclic Aromatic Hydrocarbons 52-55 flap structure-specific endonuclease 1 Homo sapiens 249-253 34164787-8 2021 Our findings revealed the linear dose-effect association between exon damage of EGFR and PAH exposure and highlight differences in genetic contributions to exon damage and have the potential to identify at-risk subpopulations who are susceptible to adverse health effects induced by PAH exposure. Polycyclic Aromatic Hydrocarbons 89-92 epidermal growth factor receptor Homo sapiens 80-84 34164787-8 2021 Our findings revealed the linear dose-effect association between exon damage of EGFR and PAH exposure and highlight differences in genetic contributions to exon damage and have the potential to identify at-risk subpopulations who are susceptible to adverse health effects induced by PAH exposure. Polycyclic Aromatic Hydrocarbons 283-286 epidermal growth factor receptor Homo sapiens 80-84 34733112-1 2021 Polyurethane foam passive air samplers (PUF-PAS) are the most common type of passive air sampler used for a range of semi-volatile organic compounds (SVOCs), including regulated persistent organic pollutants (POPs) and polycyclic aromatic hydrocarbons (PAHs), and emerging contaminants (e.g., novel flame retardants, phthalates, current-use pesticides). Polycyclic Aromatic Hydrocarbons 219-251 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 40-43 34733112-1 2021 Polyurethane foam passive air samplers (PUF-PAS) are the most common type of passive air sampler used for a range of semi-volatile organic compounds (SVOCs), including regulated persistent organic pollutants (POPs) and polycyclic aromatic hydrocarbons (PAHs), and emerging contaminants (e.g., novel flame retardants, phthalates, current-use pesticides). Polycyclic Aromatic Hydrocarbons 253-257 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 40-43 34242741-4 2021 The formation of these reactive metabolites entails metabolism of the parent PAHs by cytochrome P4501A1/1B1 (CYP1A1/1B1) and epoxide hydrolase enzymes. Polycyclic Aromatic Hydrocarbons 77-81 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 85-107 34242741-4 2021 The formation of these reactive metabolites entails metabolism of the parent PAHs by cytochrome P4501A1/1B1 (CYP1A1/1B1) and epoxide hydrolase enzymes. Polycyclic Aromatic Hydrocarbons 77-81 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 109-119 34242741-6 2021 PAH exposure also leads to upregulation of CYP1A1 transcription by binding to the aryl hydrocarbon receptor (AHR) and eliciting transcription of the CYP1A1 promoter, which comprises specific xenobiotic-responsive element (XREs). Polycyclic Aromatic Hydrocarbons 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-49 34242741-6 2021 PAH exposure also leads to upregulation of CYP1A1 transcription by binding to the aryl hydrocarbon receptor (AHR) and eliciting transcription of the CYP1A1 promoter, which comprises specific xenobiotic-responsive element (XREs). Polycyclic Aromatic Hydrocarbons 0-3 aryl hydrocarbon receptor Homo sapiens 82-107 34242741-6 2021 PAH exposure also leads to upregulation of CYP1A1 transcription by binding to the aryl hydrocarbon receptor (AHR) and eliciting transcription of the CYP1A1 promoter, which comprises specific xenobiotic-responsive element (XREs). Polycyclic Aromatic Hydrocarbons 0-3 aryl hydrocarbon receptor Homo sapiens 109-112 34242741-6 2021 PAH exposure also leads to upregulation of CYP1A1 transcription by binding to the aryl hydrocarbon receptor (AHR) and eliciting transcription of the CYP1A1 promoter, which comprises specific xenobiotic-responsive element (XREs). Polycyclic Aromatic Hydrocarbons 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 149-155 34242741-7 2021 While hepatic and pulmonary CYP1A1/1B1 metabolize PAHs to DNA-reactive metabolites, the hepatic CYP1A2, however, may protect against lung tumor development by suppressing both liver and lung CYP1A1 enzymes. Polycyclic Aromatic Hydrocarbons 50-54 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 28-34 34242741-8 2021 Further analysis of these enzymes has shown that PAH-exposure also induces sustained transcription of CYP1A1, which is independent of the persistence of the parent PAH. Polycyclic Aromatic Hydrocarbons 49-52 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 102-108 34242741-8 2021 Further analysis of these enzymes has shown that PAH-exposure also induces sustained transcription of CYP1A1, which is independent of the persistence of the parent PAH. Polycyclic Aromatic Hydrocarbons 164-167 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 102-108 34657897-10 2021 From the gas-particle partitioning ratio of 16 polycyclic aromatic hydrocarbons (PAHs) in a coal tar pitch manufacturing industry, the underestimation of the concentration of semi-volatile matters using the gas collection tubes has been discussed. Polycyclic Aromatic Hydrocarbons 81-85 gastrin Homo sapiens 9-12 34681617-12 2021 Treatments with 1 microM PHEN, 25 microM, and 10 microM FLU significantly increased KRAS mRNA expression in vitro, implying the potential basis for PAH-induced colorectal carcinogenesis. Polycyclic Aromatic Hydrocarbons 148-151 KRAS proto-oncogene, GTPase Homo sapiens 84-88 34098265-5 2021 In specific, interquartile range increases in PAHs concentrations at prior up to 9 days were observed in association with significant elevations of 2.6-2.9% in diastolic blood pressure, 6.6-8.1% in soluble ST2, 10.5-14.5% in insulin, 40.9-45.7% in osteoprotegerin, and 36.3-48.7% in interleukin-17A. Polycyclic Aromatic Hydrocarbons 46-50 insulin Homo sapiens 225-232 34328084-0 2021 The methylation of the AMER3 gene mediates the negative association between urinary polycyclic aromatic hydrocarbon metabolites and fasting plasma glucose in non-smokers: A new clue for the development of hypoglycemic agents. Polycyclic Aromatic Hydrocarbons 84-115 APC membrane recruitment protein 3 Homo sapiens 23-28 34328084-10 2021 Mediation analysis found that cg11350141 on AMER3 mediated 41.91% of the negative association of total urinary PAH metabolites with FPG. Polycyclic Aromatic Hydrocarbons 111-114 APC membrane recruitment protein 3 Homo sapiens 44-49 34402004-6 2021 A total of 11 differentially expressed PAH-responsive miRNAs were observed each in two or more cell-based studies (miR-181a and miR-30c-1), animal model studies (miR-291a and miR-292), and human population-based studies (miR-126, miR-142-5p, miR-150-5p, miR-24-3p, miR-27a-3p, miR-28-5p, and miR-320b). Polycyclic Aromatic Hydrocarbons 39-42 microRNA 30c-1 Homo sapiens 128-137 34402004-6 2021 A total of 11 differentially expressed PAH-responsive miRNAs were observed each in two or more cell-based studies (miR-181a and miR-30c-1), animal model studies (miR-291a and miR-292), and human population-based studies (miR-126, miR-142-5p, miR-150-5p, miR-24-3p, miR-27a-3p, miR-28-5p, and miR-320b). Polycyclic Aromatic Hydrocarbons 39-42 microRNA 126 Homo sapiens 221-228 34402004-6 2021 A total of 11 differentially expressed PAH-responsive miRNAs were observed each in two or more cell-based studies (miR-181a and miR-30c-1), animal model studies (miR-291a and miR-292), and human population-based studies (miR-126, miR-142-5p, miR-150-5p, miR-24-3p, miR-27a-3p, miR-28-5p, and miR-320b). Polycyclic Aromatic Hydrocarbons 39-42 microRNA 28 Homo sapiens 277-283 34215128-2 2021 Compared with Sil-ImC18 and Sil-ImC18CDs columns, Sil-ImC18/CDs column exhibited enhanced selectivity for separation of tetracyclic/tricyclic polycyclic aromatic hydrocarbon (PAH) isomers, and butylbenzene isomers in reversed-phase liquid chromatography, which may be due to the synergistic effect between ImC18CDs and (C18VIm)Br, the pi-pi interaction between imidazolium and analytes, etc. Polycyclic Aromatic Hydrocarbons 175-178 STIL centriolar assembly protein Homo sapiens 28-31 34098265-5 2021 In specific, interquartile range increases in PAHs concentrations at prior up to 9 days were observed in association with significant elevations of 2.6-2.9% in diastolic blood pressure, 6.6-8.1% in soluble ST2, 10.5-14.5% in insulin, 40.9-45.7% in osteoprotegerin, and 36.3-48.7% in interleukin-17A. Polycyclic Aromatic Hydrocarbons 46-50 TNF receptor superfamily member 11b Homo sapiens 248-263 34490489-5 2022 The change in the ratio of anthracene to anthracene plus phenanthrene (ANT/(ANT + PHE)) in this study, reflected the importance of PAH source and land use. Polycyclic Aromatic Hydrocarbons 131-134 solute carrier family 25 member 6 Homo sapiens 71-74 34490489-5 2022 The change in the ratio of anthracene to anthracene plus phenanthrene (ANT/(ANT + PHE)) in this study, reflected the importance of PAH source and land use. Polycyclic Aromatic Hydrocarbons 131-134 solute carrier family 25 member 6 Homo sapiens 76-79 34331478-0 2021 Polycyclic Aromatic Hydrocarbons Induce Endothelial Injury Through miR-155 to Promote Atherosclerosis. Polycyclic Aromatic Hydrocarbons 0-32 microRNA 155 Mus musculus 67-74 34331478-5 2021 The expression of miR-155 was upregulated by PAHs treatment, and transfection with miR-155 inhibitor could reverse above effect of PAHs-induced sclerosis. Polycyclic Aromatic Hydrocarbons 45-49 microRNA 155 Mus musculus 18-25 34331478-5 2021 The expression of miR-155 was upregulated by PAHs treatment, and transfection with miR-155 inhibitor could reverse above effect of PAHs-induced sclerosis. Polycyclic Aromatic Hydrocarbons 45-49 microRNA 155 Mus musculus 83-90 34331478-5 2021 The expression of miR-155 was upregulated by PAHs treatment, and transfection with miR-155 inhibitor could reverse above effect of PAHs-induced sclerosis. Polycyclic Aromatic Hydrocarbons 131-135 microRNA 155 Mus musculus 18-25 34331478-5 2021 The expression of miR-155 was upregulated by PAHs treatment, and transfection with miR-155 inhibitor could reverse above effect of PAHs-induced sclerosis. Polycyclic Aromatic Hydrocarbons 131-135 microRNA 155 Mus musculus 83-90 34331478-9 2021 Further in vivo experiments in ApoE-/-mice confirmed that PAH accelerates the development of arteriosclerosis by promoting the expression of miR-155 to downregulate the SERPIND1. Polycyclic Aromatic Hydrocarbons 58-61 apolipoprotein E Mus musculus 31-35 34331478-9 2021 Further in vivo experiments in ApoE-/-mice confirmed that PAH accelerates the development of arteriosclerosis by promoting the expression of miR-155 to downregulate the SERPIND1. Polycyclic Aromatic Hydrocarbons 58-61 microRNA 155 Mus musculus 141-148 34331478-9 2021 Further in vivo experiments in ApoE-/-mice confirmed that PAH accelerates the development of arteriosclerosis by promoting the expression of miR-155 to downregulate the SERPIND1. Polycyclic Aromatic Hydrocarbons 58-61 serine (or cysteine) peptidase inhibitor, clade D, member 1 Mus musculus 169-177 34331478-10 2021 Therefore, PAH exaggerates atherosclerosis by activating miR-155-dependent endothelial injury. Polycyclic Aromatic Hydrocarbons 11-14 microRNA 155 Mus musculus 57-64 34754473-0 2021 Association between prenatal polycyclic aromatic hydrocarbons and infantile allergic diseases modified by maternal glutathione S-transferase polymorphisms: results from the MOCEH birth cohort. Polycyclic Aromatic Hydrocarbons 29-61 glutathione S-transferase kappa 1 Homo sapiens 115-140 34159366-1 2022 Electrospun polyacrylonitrile/clinoptilolite (PAN/CP) nanofibers were used to extract polycyclic aromatic hydrocarbons (PAHs) (acenaphthene, acenaphthylene, naphthalene, and phenanthrene) from water samples by solid-phase microextraction (SPME). Polycyclic Aromatic Hydrocarbons 86-118 adenosine deaminase 2 Homo sapiens 46-52 34159366-1 2022 Electrospun polyacrylonitrile/clinoptilolite (PAN/CP) nanofibers were used to extract polycyclic aromatic hydrocarbons (PAHs) (acenaphthene, acenaphthylene, naphthalene, and phenanthrene) from water samples by solid-phase microextraction (SPME). Polycyclic Aromatic Hydrocarbons 120-124 adenosine deaminase 2 Homo sapiens 46-52 34203819-6 2021 Compared with a commercially available octadecylated silica column, the Sil-VPG15 stationary phase showed high selectivity toward polycyclic aromatic hydrocarbons, and particularly excellent separations were obtained for geometrical and positional isomers. Polycyclic Aromatic Hydrocarbons 130-162 STIL centriolar assembly protein Homo sapiens 72-75 34136305-0 2021 Analysis of Polycyclic Aromatic Hydrocarbon in Airborne Particulate Matter Samples by Gas Chromatography in Combination with Tandem Mass Spectrometry (GC-MS/MS). Polycyclic Aromatic Hydrocarbons 12-43 gastrin Homo sapiens 86-89 34095084-4 2021 MD results show that PAH can merely enter into the cavity of SBE-beta-CD from its wide rim. Polycyclic Aromatic Hydrocarbons 21-24 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 65-72 34754473-3 2021 We sought to examine the association between prenatal PAH exposure and infantile allergic diseases in 6-month-old infants, and how maternal glutathione S-transferase M1 (GSTM1) or T1 (GSTT1) polymorphism affects the association between prenatal PAH exposure and allergic diseases in the Mothers and Children"s Environmental Health (MOCEH) study. Polycyclic Aromatic Hydrocarbons 245-248 glutathione S-transferase mu 1 Homo sapiens 140-168 34754473-3 2021 We sought to examine the association between prenatal PAH exposure and infantile allergic diseases in 6-month-old infants, and how maternal glutathione S-transferase M1 (GSTM1) or T1 (GSTT1) polymorphism affects the association between prenatal PAH exposure and allergic diseases in the Mothers and Children"s Environmental Health (MOCEH) study. Polycyclic Aromatic Hydrocarbons 245-248 glutathione S-transferase mu 1 Homo sapiens 170-175 34754473-3 2021 We sought to examine the association between prenatal PAH exposure and infantile allergic diseases in 6-month-old infants, and how maternal glutathione S-transferase M1 (GSTM1) or T1 (GSTT1) polymorphism affects the association between prenatal PAH exposure and allergic diseases in the Mothers and Children"s Environmental Health (MOCEH) study. Polycyclic Aromatic Hydrocarbons 245-248 glutathione S-transferase theta 1 Homo sapiens 184-189 34754473-10 2021 Conclusions: The present study found that infantile allergic diseases could be affected by intrauterine PAH exposure, particularly in the early prenatal period and the risk was limited to the maternal GSTT1 null type. Polycyclic Aromatic Hydrocarbons 104-107 glutathione S-transferase theta 1 Homo sapiens 201-206 34734210-3 2021 In addition, in vitro and rodent studies have implicated alterations in estrogen receptor alpha (Eralpha) signaling pathways following PAH exposure in limited experimental studies. Polycyclic Aromatic Hydrocarbons 135-138 estrogen receptor 1 (alpha) Mus musculus 72-95 34734210-3 2021 In addition, in vitro and rodent studies have implicated alterations in estrogen receptor alpha (Eralpha) signaling pathways following PAH exposure in limited experimental studies. Polycyclic Aromatic Hydrocarbons 135-138 estrogen receptor 1 (alpha) Mus musculus 97-104 34734210-6 2021 addressed this gap by examining the effect of PAH exposure on epigenetic and transcriptional regulation of genes in the Eralpha pathway in a mouse cohort exposed to aerosolized PAH at proportions measured in urban air. Polycyclic Aromatic Hydrocarbons 46-49 estrogen receptor 1 (alpha) Mus musculus 120-127 34734210-7 2021 In addition to alterations in the Eralpha signaling pathway in the pregnant mice and in their offspring and grandoffspring, the investigators observed higher body weights in mice exposed to PAH compared to the control. Polycyclic Aromatic Hydrocarbons 190-193 estrogen receptor 1 (alpha) Mus musculus 34-41 35390378-5 2022 Phe, Flt, Pyr, Nap, Chr, BbF, and BkF were found as the dominant species in TSP and PM2.5, indicating a dominant contribution of PAHs from diesel-fueled vehicular emissions. Polycyclic Aromatic Hydrocarbons 129-133 thrombospondin 1 Homo sapiens 76-79 35390378-6 2022 The bioaccessible fractions measured for different PAH species in tunnel PM2.5 and TSP were highly variable, which can be attributed to PAHs" physicochemical properties, size, and carbonaceous materials of TIPM. Polycyclic Aromatic Hydrocarbons 51-54 thrombospondin 1 Homo sapiens 83-86 35490956-7 2022 N-, B-, O, N-B-, and N-S-doping of biochar reduced polycyclic aromatic hydrocarbon formation by 90, 85, 87, 97, and 89%, respectively. Polycyclic Aromatic Hydrocarbons 51-82 serine peptidase inhibitor Kazal type 5 Homo sapiens 21-24 35134381-0 2022 Polycyclic aromatic hydrocarbons in sediment-porewater system from the East China Sea: Occurrence, partitioning, and diffusion. Polycyclic Aromatic Hydrocarbons 0-32 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 82-85 35429817-12 2022 In summary, VitD and VDR promote biological detoxication on PM2.5 though PAH degradation from a molecular effect, and exert anti-inflammatory effects against NLRP3/IL-1beta axis caused by PM2.5. Polycyclic Aromatic Hydrocarbons 73-76 vitamin D (1,25-dihydroxyvitamin D3) receptor Mus musculus 21-24 35377459-1 2022 The aryl hydrocarbon receptor (AHR) is required for vertebrate development and is also activated by exogenous chemicals, including polycyclic aromatic hydrocarbons (PAHs) and TCDD. Polycyclic Aromatic Hydrocarbons 131-163 aryl hydrocarbon receptor 1a Danio rerio 4-29 35377459-1 2022 The aryl hydrocarbon receptor (AHR) is required for vertebrate development and is also activated by exogenous chemicals, including polycyclic aromatic hydrocarbons (PAHs) and TCDD. Polycyclic Aromatic Hydrocarbons 131-163 aryl hydrocarbon receptor 1a Danio rerio 31-34 35377459-1 2022 The aryl hydrocarbon receptor (AHR) is required for vertebrate development and is also activated by exogenous chemicals, including polycyclic aromatic hydrocarbons (PAHs) and TCDD. Polycyclic Aromatic Hydrocarbons 165-169 aryl hydrocarbon receptor 1a Danio rerio 4-29 35377459-1 2022 The aryl hydrocarbon receptor (AHR) is required for vertebrate development and is also activated by exogenous chemicals, including polycyclic aromatic hydrocarbons (PAHs) and TCDD. Polycyclic Aromatic Hydrocarbons 165-169 aryl hydrocarbon receptor 1a Danio rerio 31-34 35597001-0 2022 Occurrence, origin and potential ecological risk of dissolved polycyclic aromatic hydrocarbons and organochlorines in surface waters of the Gulf of Gabes (Tunisia, Southern Mediterranean Sea). Polycyclic Aromatic Hydrocarbons 62-94 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 187-190 35546785-1 2022 OBJECTIVE: To evaluate the interaction effects of Polycyclic aromatic hydrocarbons (PAHs) exposure and variants in cGAS-STING genes on mitochondrial DNA copy number (mtDNAcn) in workers. Polycyclic Aromatic Hydrocarbons 50-82 stimulator of interferon response cGAMP interactor 1 Homo sapiens 120-125 35546785-1 2022 OBJECTIVE: To evaluate the interaction effects of Polycyclic aromatic hydrocarbons (PAHs) exposure and variants in cGAS-STING genes on mitochondrial DNA copy number (mtDNAcn) in workers. Polycyclic Aromatic Hydrocarbons 84-88 stimulator of interferon response cGAMP interactor 1 Homo sapiens 120-125 35066031-0 2022 Ecological and AhR-mediated risk assessment of polycyclic aromatic hydrocarbons and polybrominated diphenyl ethers on multiple aquatic species in river water: A combined chemical analysis and in silico approach. Polycyclic Aromatic Hydrocarbons 47-79 aryl hydrocarbon receptor Homo sapiens 15-18 35066031-7 2022 Phe and BDE209 were the significant contributor to the AhR-mediated risk induced by PAHs and PBDEs, respectively. Polycyclic Aromatic Hydrocarbons 84-88 aryl hydrocarbon receptor Homo sapiens 55-58 35344733-0 2022 Establishment of cytochrome P450 1a gene-knockout Javanese medaka, Oryzias javanicus, which distinguishes toxicity modes of the polycyclic aromatic hydrocarbons, pyrene and phenanthrene. Polycyclic Aromatic Hydrocarbons 128-160 cytochrome P450 1A1 Oryzias latipes 17-35 35204652-5 2022 In this study, we aimed at exploring the substrate scope of CYP3A4 towards (N-/O)-PAHs and conducted a bioconversion experiment at 10 L scale to validate the synthetic potential of CYP3A4 for the preparative-scale production of functionalized PAH metabolites. Polycyclic Aromatic Hydrocarbons 243-246 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 60-66 35449013-9 2022 The phosphorylated levels of focal adhesion kinase (FAK) and formation of the focal adhesion complex were significantly increased in ambient PM or PAH-treated VSMCs, and these effects were blocked by administration of NAC or alpha-NF, an inhibitor of AhR, the receptor that allows PAH uptake. Polycyclic Aromatic Hydrocarbons 147-150 protein tyrosine kinase 2 Homo sapiens 29-50 35449013-9 2022 The phosphorylated levels of focal adhesion kinase (FAK) and formation of the focal adhesion complex were significantly increased in ambient PM or PAH-treated VSMCs, and these effects were blocked by administration of NAC or alpha-NF, an inhibitor of AhR, the receptor that allows PAH uptake. Polycyclic Aromatic Hydrocarbons 147-150 protein tyrosine kinase 2 Homo sapiens 52-55 35449013-9 2022 The phosphorylated levels of focal adhesion kinase (FAK) and formation of the focal adhesion complex were significantly increased in ambient PM or PAH-treated VSMCs, and these effects were blocked by administration of NAC or alpha-NF, an inhibitor of AhR, the receptor that allows PAH uptake. Polycyclic Aromatic Hydrocarbons 147-150 aryl hydrocarbon receptor Homo sapiens 251-254 35449013-9 2022 The phosphorylated levels of focal adhesion kinase (FAK) and formation of the focal adhesion complex were significantly increased in ambient PM or PAH-treated VSMCs, and these effects were blocked by administration of NAC or alpha-NF, an inhibitor of AhR, the receptor that allows PAH uptake. Polycyclic Aromatic Hydrocarbons 281-284 protein tyrosine kinase 2 Homo sapiens 29-50 35449013-9 2022 The phosphorylated levels of focal adhesion kinase (FAK) and formation of the focal adhesion complex were significantly increased in ambient PM or PAH-treated VSMCs, and these effects were blocked by administration of NAC or alpha-NF, an inhibitor of AhR, the receptor that allows PAH uptake. Polycyclic Aromatic Hydrocarbons 281-284 protein tyrosine kinase 2 Homo sapiens 52-55 35204761-0 2022 Correlation of Occupational Exposure to Carcinogenic Polycyclic Aromatic Hydrocarbons (cPAHs) and Blood Levels of p53 and p21 Proteins. Polycyclic Aromatic Hydrocarbons 53-85 tumor protein p53 Homo sapiens 114-117 35204761-0 2022 Correlation of Occupational Exposure to Carcinogenic Polycyclic Aromatic Hydrocarbons (cPAHs) and Blood Levels of p53 and p21 Proteins. Polycyclic Aromatic Hydrocarbons 53-85 H3 histone pseudogene 16 Homo sapiens 122-125 35392076-0 2022 Polycyclic Aromatic Hydrocarbons Affect Rheumatoid Arthritis Pathogenesis via Aryl Hydrocarbon Receptor. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 78-103 35287592-0 2022 The relationship between polycyclic aromatic hydrocarbons exposure and serum klotho among adult population. Polycyclic Aromatic Hydrocarbons 25-57 klotho Homo sapiens 77-83 35287592-3 2022 The aim of the current study was to determine the relationship between serum klotho and PAHs exposure in an adult population. Polycyclic Aromatic Hydrocarbons 88-92 klotho Homo sapiens 77-83 35287592-9 2022 After fully adjusting pertinent variables, PAH exposure was significantly associated with decreased klotho, particularly in men. Polycyclic Aromatic Hydrocarbons 43-46 klotho Homo sapiens 100-106 35287592-10 2022 CONCLUSION: In the present study we highlighted the significant association between PAHs exposure and serum klotho levels. Polycyclic Aromatic Hydrocarbons 84-88 klotho Homo sapiens 108-114 35149264-0 2022 Comprehensive investigation of binding of some polycyclic aromatic hydrocarbons with bovine serum albumin: Spectroscopic and molecular docking studies. Polycyclic Aromatic Hydrocarbons 47-79 albumin Homo sapiens 92-105 35149264-1 2022 The interactions of phenanthrene (PHTN), fluorene (FLRN) and fluoranthene (FLRT) as polycyclic aromatic hydrocarbons (PAHs) with bovine serum albumin (BSA) were explored employing spectroscopic approaches and molecular docking simulations. Polycyclic Aromatic Hydrocarbons 84-116 albumin Homo sapiens 136-149 35149264-1 2022 The interactions of phenanthrene (PHTN), fluorene (FLRN) and fluoranthene (FLRT) as polycyclic aromatic hydrocarbons (PAHs) with bovine serum albumin (BSA) were explored employing spectroscopic approaches and molecular docking simulations. Polycyclic Aromatic Hydrocarbons 118-122 albumin Homo sapiens 136-149 35180652-0 2022 Polymorphisms in PAH metabolising enzyme CYP1A1 in colorectal cancer and their clinicopathological correlations. Polycyclic Aromatic Hydrocarbons 17-20 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 41-47 35180652-1 2022 CYP1A1 enzyme is integral to the biotransformation of polycyclic aromatic hydrocarbons to carcinogenic compounds. Polycyclic Aromatic Hydrocarbons 54-86 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 35267346-0 2022 Trace-Level Determination of Polycyclic Aromatic Hydrocarbons in Dairy Products Available in Spanish Supermarkets by Semi-Automated Solid-Phase Extraction and Gas Chromatography-Mass Spectrometry Detection. Polycyclic Aromatic Hydrocarbons 29-61 gastrin Homo sapiens 159-162 35199223-1 2022 Benzo(a)pyrene (BaP) is a high molecular weight polycyclic aromatic hydrocarbon produced as a result of incomplete combustion of organic substances. Polycyclic Aromatic Hydrocarbons 48-79 prohibitin 2 Homo sapiens 16-19 35192163-4 2022 Therefore, the objective of this study was to evaluate the effect of the interaction between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and polycyclic aromatic hydrocarbon (PAH) exposure (gene-environment interaction) on cardiovascular risk biomarkers in Mexican women. Polycyclic Aromatic Hydrocarbons 160-191 methylenetetrahydrofolate reductase Homo sapiens 93-128 35192163-4 2022 Therefore, the objective of this study was to evaluate the effect of the interaction between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and polycyclic aromatic hydrocarbon (PAH) exposure (gene-environment interaction) on cardiovascular risk biomarkers in Mexican women. Polycyclic Aromatic Hydrocarbons 160-191 methylenetetrahydrofolate reductase Homo sapiens 130-135 35192163-4 2022 Therefore, the objective of this study was to evaluate the effect of the interaction between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and polycyclic aromatic hydrocarbon (PAH) exposure (gene-environment interaction) on cardiovascular risk biomarkers in Mexican women. Polycyclic Aromatic Hydrocarbons 193-196 methylenetetrahydrofolate reductase Homo sapiens 93-128 35192163-4 2022 Therefore, the objective of this study was to evaluate the effect of the interaction between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and polycyclic aromatic hydrocarbon (PAH) exposure (gene-environment interaction) on cardiovascular risk biomarkers in Mexican women. Polycyclic Aromatic Hydrocarbons 193-196 methylenetetrahydrofolate reductase Homo sapiens 130-135 35209168-1 2022 Benzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) primarily formed by burning of fossil fuels, wood and other organic materials. Polycyclic Aromatic Hydrocarbons 26-57 prohibitin 2 Homo sapiens 16-19 35209168-1 2022 Benzo(a)pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) primarily formed by burning of fossil fuels, wood and other organic materials. Polycyclic Aromatic Hydrocarbons 59-62 prohibitin 2 Homo sapiens 16-19 35040851-0 2022 Gas-phase thermochemistry of polycyclic aromatic hydrocarbons: an approach integrating the quantum chemistry composite scheme and reaction generator. Polycyclic Aromatic Hydrocarbons 29-61 PAXIP1 associated glutamate rich protein 1 Homo sapiens 0-3 35040851-1 2022 We introduce a protocol aimed at predicting the accurate gas-phase enthalpies of formation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 94-126 PAXIP1 associated glutamate rich protein 1 Homo sapiens 57-60 35040851-1 2022 We introduce a protocol aimed at predicting the accurate gas-phase enthalpies of formation of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 128-132 PAXIP1 associated glutamate rich protein 1 Homo sapiens 57-60 35204652-5 2022 In this study, we aimed at exploring the substrate scope of CYP3A4 towards (N-/O)-PAHs and conducted a bioconversion experiment at 10 L scale to validate the synthetic potential of CYP3A4 for the preparative-scale production of functionalized PAH metabolites. Polycyclic Aromatic Hydrocarbons 243-246 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 181-187 35051069-2 2022 The exposure of humans to this PAH can be assessed by measuring stable blood protein adducts, such as to histidine and lysine in serum albumin, from their reactive metabolites. Polycyclic Aromatic Hydrocarbons 31-34 albumin Homo sapiens 135-142 35052622-13 2022 Our results suggest that a combination of mechanism entailing CYP1B1 inhibition and the modulation of DNA repair genes contribute to the attenuation of PAH-mediated carcinogenesis by omega 3 fatty acids. Polycyclic Aromatic Hydrocarbons 152-155 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 62-68 35011557-0 2022 Unpredicted Concentration-Dependent Sensory Properties of Pyrene-Containing NBN-Doped Polycyclic Aromatic Hydrocarbons. Polycyclic Aromatic Hydrocarbons 86-118 nibrin Homo sapiens 76-79 35011557-1 2022 Pyrene molecules containing NBN-doped polycyclic aromatic hydrocarbons (PAHs) have been synthesized by a simple and efficient intermolecular dehydration reaction between 1-pyrenylboronic acid and aromatic diamine. Polycyclic Aromatic Hydrocarbons 72-76 nibrin Homo sapiens 28-31 35090271-0 2022 Polycyclic aromatic hydrocarbons in seawater, surface sediment, and marine organisms of Haizhou Bay in Yellow Sea, China: Distribution, source apportionment, and health risk assessment. Polycyclic Aromatic Hydrocarbons 0-32 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 110-113 35527008-0 2022 Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage expression of interleukin-33 induced by exposure to particulate matter. Polycyclic Aromatic Hydrocarbons 15-47 interleukin 33 Homo sapiens 90-104 35527008-5 2022 PM2.5-induced IL-33 expression was significantly attenuated in AhR-knockout or TLR4-mutated macrophages, suggesting an important role of polycyclic aromatic hydrocarbons (PAHs) and endotoxin in IL-33 stimulation. Polycyclic Aromatic Hydrocarbons 137-169 interleukin 33 Homo sapiens 14-19 35527008-5 2022 PM2.5-induced IL-33 expression was significantly attenuated in AhR-knockout or TLR4-mutated macrophages, suggesting an important role of polycyclic aromatic hydrocarbons (PAHs) and endotoxin in IL-33 stimulation. Polycyclic Aromatic Hydrocarbons 137-169 aryl hydrocarbon receptor Homo sapiens 63-66 35112968-5 2022 Moreover, source apportionment study indicated that major PAH-emission sources in Delhi NCR are traffic and coal combustion. Polycyclic Aromatic Hydrocarbons 58-61 Neutrophil migration (granulocyte glycoprotein) Homo sapiens 88-91 2773513-2 1989 The effects of acute treatment of 3-methylcholanthrene (MC)-induced rats with carbon tetrachloride (CCl4) on the content and activity of the polycyclic aromatic hydrocarbon-inducible forms of cytochrome P-450 (P-450c and P-450d) in liver and kidney have been determined. Polycyclic Aromatic Hydrocarbons 141-172 C-C motif chemokine ligand 4 Rattus norvegicus 100-104 2775307-1 1989 Effect of polycyclic aromatic hydrocarbons on cytochrome P-450 regulation. Polycyclic Aromatic Hydrocarbons 10-42 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 46-62 2775307-5 1989 An increase in monooxygenase activities related to P-450c and P-450d isoenzymes specifically induced by PAH was noticed, whereas no effect could be detected on the glucuronidation rate of either 4-nitrophenol, testosterone or estrone. Polycyclic Aromatic Hydrocarbons 104-107 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 51-68 2775307-6 1989 As determined by immunoquantification after Western blotting, the isoenzymatic profile of P-450 from PAH-treated male Gunn rats showed an increase of P-450c and P-450d accompanied by an equivalent decrease in P-4502c (major male-specific isoenzyme). Polycyclic Aromatic Hydrocarbons 101-104 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 150-167 2504573-12 1989 These included a chimeric promoter containing the polycyclic aromatic hydrocarbon-responsive enhancer of the cytochrome P450c gene (CYP1A1), which was shown to confer upon the CAT gene responsiveness to polycyclic aromatic hydrocarbons comparable to that of the native P450c gene. Polycyclic Aromatic Hydrocarbons 50-81 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 120-125 2504573-12 1989 These included a chimeric promoter containing the polycyclic aromatic hydrocarbon-responsive enhancer of the cytochrome P450c gene (CYP1A1), which was shown to confer upon the CAT gene responsiveness to polycyclic aromatic hydrocarbons comparable to that of the native P450c gene. Polycyclic Aromatic Hydrocarbons 50-81 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 132-138 2504573-12 1989 These included a chimeric promoter containing the polycyclic aromatic hydrocarbon-responsive enhancer of the cytochrome P450c gene (CYP1A1), which was shown to confer upon the CAT gene responsiveness to polycyclic aromatic hydrocarbons comparable to that of the native P450c gene. Polycyclic Aromatic Hydrocarbons 50-81 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 269-274 2504573-12 1989 These included a chimeric promoter containing the polycyclic aromatic hydrocarbon-responsive enhancer of the cytochrome P450c gene (CYP1A1), which was shown to confer upon the CAT gene responsiveness to polycyclic aromatic hydrocarbons comparable to that of the native P450c gene. Polycyclic Aromatic Hydrocarbons 203-235 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 120-125 2504573-12 1989 These included a chimeric promoter containing the polycyclic aromatic hydrocarbon-responsive enhancer of the cytochrome P450c gene (CYP1A1), which was shown to confer upon the CAT gene responsiveness to polycyclic aromatic hydrocarbons comparable to that of the native P450c gene. Polycyclic Aromatic Hydrocarbons 203-235 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 132-138 2546564-2 1989 Both cell lines demonstrated polycyclic aromatic hydrocarbon (PAH)-induced AHH activity; however, assay conditions for induction were different than those established for the control mouse hepatoma cell line, Hepa c1-9. Polycyclic Aromatic Hydrocarbons 29-60 aryl-hydrocarbon receptor Mus musculus 75-78 2546564-2 1989 Both cell lines demonstrated polycyclic aromatic hydrocarbon (PAH)-induced AHH activity; however, assay conditions for induction were different than those established for the control mouse hepatoma cell line, Hepa c1-9. Polycyclic Aromatic Hydrocarbons 62-65 aryl-hydrocarbon receptor Mus musculus 75-78 2546564-2 1989 Both cell lines demonstrated polycyclic aromatic hydrocarbon (PAH)-induced AHH activity; however, assay conditions for induction were different than those established for the control mouse hepatoma cell line, Hepa c1-9. Polycyclic Aromatic Hydrocarbons 62-65 Rho GTPase activating protein 4 Mus musculus 214-218 35527008-5 2022 PM2.5-induced IL-33 expression was significantly attenuated in AhR-knockout or TLR4-mutated macrophages, suggesting an important role of polycyclic aromatic hydrocarbons (PAHs) and endotoxin in IL-33 stimulation. Polycyclic Aromatic Hydrocarbons 137-169 toll like receptor 4 Homo sapiens 79-83 35527008-5 2022 PM2.5-induced IL-33 expression was significantly attenuated in AhR-knockout or TLR4-mutated macrophages, suggesting an important role of polycyclic aromatic hydrocarbons (PAHs) and endotoxin in IL-33 stimulation. Polycyclic Aromatic Hydrocarbons 137-169 interleukin 33 Homo sapiens 194-199 35527008-5 2022 PM2.5-induced IL-33 expression was significantly attenuated in AhR-knockout or TLR4-mutated macrophages, suggesting an important role of polycyclic aromatic hydrocarbons (PAHs) and endotoxin in IL-33 stimulation. Polycyclic Aromatic Hydrocarbons 171-175 interleukin 33 Homo sapiens 14-19 35527008-5 2022 PM2.5-induced IL-33 expression was significantly attenuated in AhR-knockout or TLR4-mutated macrophages, suggesting an important role of polycyclic aromatic hydrocarbons (PAHs) and endotoxin in IL-33 stimulation. Polycyclic Aromatic Hydrocarbons 171-175 aryl hydrocarbon receptor Homo sapiens 63-66 35527008-5 2022 PM2.5-induced IL-33 expression was significantly attenuated in AhR-knockout or TLR4-mutated macrophages, suggesting an important role of polycyclic aromatic hydrocarbons (PAHs) and endotoxin in IL-33 stimulation. Polycyclic Aromatic Hydrocarbons 171-175 toll like receptor 4 Homo sapiens 79-83 35527008-9 2022 These data suggest that the potency of IL-33 induction could depend on the concentration of PAHs as well as endotoxin in PMs. Polycyclic Aromatic Hydrocarbons 92-96 interleukin 33 Homo sapiens 39-44 2509067-0 1989 Roles of individual human cytochrome P-450 enzymes in the bioactivation of benzo(a)pyrene, 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and other dihydrodiol derivatives of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 169-201 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 26-42 2773513-2 1989 The effects of acute treatment of 3-methylcholanthrene (MC)-induced rats with carbon tetrachloride (CCl4) on the content and activity of the polycyclic aromatic hydrocarbon-inducible forms of cytochrome P-450 (P-450c and P-450d) in liver and kidney have been determined. Polycyclic Aromatic Hydrocarbons 141-172 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 192-208 2773513-2 1989 The effects of acute treatment of 3-methylcholanthrene (MC)-induced rats with carbon tetrachloride (CCl4) on the content and activity of the polycyclic aromatic hydrocarbon-inducible forms of cytochrome P-450 (P-450c and P-450d) in liver and kidney have been determined. Polycyclic Aromatic Hydrocarbons 141-172 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 210-216 11542167-3 1989 We present airborne 5-8 micrometers spectra of southern IRAS sources which reveal strong polycyclic aromatic hydrocarbon (PAH) emission features. Polycyclic Aromatic Hydrocarbons 89-120 nischarin Homo sapiens 56-60 11542167-3 1989 We present airborne 5-8 micrometers spectra of southern IRAS sources which reveal strong polycyclic aromatic hydrocarbon (PAH) emission features. Polycyclic Aromatic Hydrocarbons 122-125 nischarin Homo sapiens 56-60 11542167-9 1989 Several of our sources show definite evidence for emission structure between 14 and 23 micrometers in their IRAS Low-Resolution Spectral Atlas spectra: we attribute this structure to PAH bands. Polycyclic Aromatic Hydrocarbons 184-187 nischarin Homo sapiens 108-112 2505924-1 1989 C3H/10T1/2 clone 8 (10T1/2) cells possess aryl hydrocarbon hydroxylase (AHH) activity capable of metabolizing polycyclic aromatic hydrocarbons to ultimate carcinogenic forms. Polycyclic Aromatic Hydrocarbons 110-142 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 42-70 2505924-1 1989 C3H/10T1/2 clone 8 (10T1/2) cells possess aryl hydrocarbon hydroxylase (AHH) activity capable of metabolizing polycyclic aromatic hydrocarbons to ultimate carcinogenic forms. Polycyclic Aromatic Hydrocarbons 110-142 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 72-75 2916850-1 1989 The actions of polycyclic aromatic hydrocarbons and glucocorticoids to regulate the expression of cytochrome P450c were investigated using cultured fetal rat hepatocytes. Polycyclic Aromatic Hydrocarbons 15-47 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 98-114 2916850-10 1989 It is concluded that glucocorticoids act together with polycyclic aromatic hydrocarbons to increase the levels of cytochrome P450c expressed in the fetal rat hepatocyte, and that this action is mediated by the glucocorticoid receptor. Polycyclic Aromatic Hydrocarbons 55-87 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 114-130 2912553-2 1989 A major form of cytochrome P-450 was purified from skin microsomes of mice treated with polycyclic aromatic hydrocarbon. Polycyclic Aromatic Hydrocarbons 88-119 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 16-32 2483074-4 1989 Both main-stream and side-stream cigarette smoke condensates and some fractions, containing water-soluble bases, water-insoluble bases, and polycyclic aromatic hydrocarbons, were found to induce AHH activity in lung and liver, the lung being induced to the greatest extent. Polycyclic Aromatic Hydrocarbons 140-172 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 195-198 2764709-1 1989 A hepatic soluble aldehyde dehydrogenase (ALDH), inducible by polycyclic aromatic hydrocarbons, was studied in Wistar rats in connection with substances known to affect drug metabolism or aldehyde dehydrogenase activity, such as phenobarbital (PB), disulfiram (DS), beta-diethylaminoethyl diphenylpropylacetate (SKF 525A) and calcium cyanamide (CC). Polycyclic Aromatic Hydrocarbons 62-94 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 18-40 2764709-1 1989 A hepatic soluble aldehyde dehydrogenase (ALDH), inducible by polycyclic aromatic hydrocarbons, was studied in Wistar rats in connection with substances known to affect drug metabolism or aldehyde dehydrogenase activity, such as phenobarbital (PB), disulfiram (DS), beta-diethylaminoethyl diphenylpropylacetate (SKF 525A) and calcium cyanamide (CC). Polycyclic Aromatic Hydrocarbons 62-94 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 42-46 2680945-9 1989 In particular, we have utilized a mouse model system wherein a single dominant gene, Ah, confers responsiveness to induction of PAH metabolism by cytochrome Pl450 (IA1); the recessive allele, Ah, is associated with nonresponsiveness. Polycyclic Aromatic Hydrocarbons 128-131 insulinoma-associated 1 Mus musculus 164-167 3415236-9 1988 Photolysis of BaP and similar PAH compounds represents a useful treatment option that could be applied to certain PAH-containing petroleum refinery sludge and to coal tar residues in order to facilitate their detoxification and environmentally safe disposal. Polycyclic Aromatic Hydrocarbons 114-117 prohibitin 2 Homo sapiens 14-17 2897254-0 1988 2,3,7,8-Tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons suppress retinoid-induced tissue transglutaminase in SCC-4 cultured human squamous carcinoma cells. Polycyclic Aromatic Hydrocarbons 40-72 transglutaminase 2 Homo sapiens 99-122 2897254-0 1988 2,3,7,8-Tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons suppress retinoid-induced tissue transglutaminase in SCC-4 cultured human squamous carcinoma cells. Polycyclic Aromatic Hydrocarbons 40-72 MAU2 sister chromatid cohesion factor Homo sapiens 126-131 3146175-0 1988 [Nitrated polycyclic aromatic hydrocarbons (nitro-PAH) in suspended particles in the atmosphere. Polycyclic Aromatic Hydrocarbons 10-42 phenylalanine hydroxylase Homo sapiens 50-53 3270515-7 1988 The AHH activity of lung cancer patients seems more sensitive to induction by polycyclic aromatic hydrocarbons than that of noncancer patients. Polycyclic Aromatic Hydrocarbons 78-110 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 4-7 2458855-0 1988 Elevation of polycyclic aromatic hydrocarbon-inducible aryl hydrocarbon hydroxylase activity in rat hepatocytes in primary culture by inhibitors of poly(ADP-ribose) polymerase. Polycyclic Aromatic Hydrocarbons 13-44 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 55-83 2458855-0 1988 Elevation of polycyclic aromatic hydrocarbon-inducible aryl hydrocarbon hydroxylase activity in rat hepatocytes in primary culture by inhibitors of poly(ADP-ribose) polymerase. Polycyclic Aromatic Hydrocarbons 13-44 poly (ADP-ribose) polymerase 1 Rattus norvegicus 148-175 3379039-1 1988 In both primary cell cultures of rat hepatocytes and in liver, polycyclic aromatic hydrocarbons (PAHs) were found to influence the accumulation of the cytochrome P-450c and P-450d mRNAs by both transcriptional and post-transcriptional mechanisms. Polycyclic Aromatic Hydrocarbons 63-95 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 151-168 3379039-1 1988 In both primary cell cultures of rat hepatocytes and in liver, polycyclic aromatic hydrocarbons (PAHs) were found to influence the accumulation of the cytochrome P-450c and P-450d mRNAs by both transcriptional and post-transcriptional mechanisms. Polycyclic Aromatic Hydrocarbons 63-95 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 173-179 3379039-1 1988 In both primary cell cultures of rat hepatocytes and in liver, polycyclic aromatic hydrocarbons (PAHs) were found to influence the accumulation of the cytochrome P-450c and P-450d mRNAs by both transcriptional and post-transcriptional mechanisms. Polycyclic Aromatic Hydrocarbons 97-101 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 151-168 3379039-1 1988 In both primary cell cultures of rat hepatocytes and in liver, polycyclic aromatic hydrocarbons (PAHs) were found to influence the accumulation of the cytochrome P-450c and P-450d mRNAs by both transcriptional and post-transcriptional mechanisms. Polycyclic Aromatic Hydrocarbons 97-101 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 173-179 3379039-4 1988 Following treatment with PAHs, cytochrome P-450d mRNA levels increased 200-fold in hepatocyte cultures and 70-fold in liver, while transcription rates remained unchanged in hepatocyte cultures and increased only 1.7-fold in liver. Polycyclic Aromatic Hydrocarbons 25-29 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 31-48 3379039-9 1988 The cytochrome P-450c mRNA was found in kidney, heart, and lung, as well as in liver, of PAH-treated rats, while the mature cytochrome P-450d mRNA was detected only in liver. Polycyclic Aromatic Hydrocarbons 89-92 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 4-21 2898344-0 1988 N-benzylimidazole, a high magnitude inducer of rat hepatic cytochrome P-450 exhibiting both polycyclic aromatic hydrocarbon- and phenobarbital-type induction of phase I and phase II drug-metabolizing enzymes. Polycyclic Aromatic Hydrocarbons 92-124 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 59-75 3356707-1 1988 A 29-kDa cytosolic protein that binds polycyclic aromatic hydrocarbons (PBP) with high affinity, specificity and saturability was identified in and was purified from C57BL/6J mouse liver (Collins, S., and Marletta, M. A. Polycyclic Aromatic Hydrocarbons 38-70 mediator complex subunit 1 Mus musculus 72-75 2898344-3 1988 N-Benzylimidazole exhibited mixed type induction of cytochrome P-450, producing both polycyclic aromatic hydrocarbon- and phenobarbital-type induction. Polycyclic Aromatic Hydrocarbons 85-116 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 52-68 3335509-2 1988 Hepatic mitoplasts from 3-methylcholanthrene-treated rats contain cytochrome P-450 which can metabolize polycyclic aromatic hydrocarbons like benzo(a)pyrene. Polycyclic Aromatic Hydrocarbons 104-136 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 66-82 3276319-0 1988 Stereoselectivity of cytochrome P-450 isozymes and epoxide hydrolase in the metabolism of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 90-122 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 21-37 3276319-2 1988 Cytochrome P-450 isozymes contained in various liver microsomal preparations have varying degrees of stereoselectivity in catalyzing the epoxidation reactions at various formal double bonds of the polycyclic aromatic hydrocarbons studied. Polycyclic Aromatic Hydrocarbons 197-229 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-16 2446793-3 1988 The results demonstrate that AHH activity in the H4IIE cell line can be induced by extracts of particulates collected from urban air and automobile exhausts in a dose-dependent manner, and that the AHH activity is inducible by five polycyclic aromatic hydrocarbons (PAHs) including 1-/3-nitrobenzo[a]pyrene and 6-chlorochrysene, all present in extracts of particulates from urban air and automobile exhausts. Polycyclic Aromatic Hydrocarbons 232-264 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 29-32 2446793-3 1988 The results demonstrate that AHH activity in the H4IIE cell line can be induced by extracts of particulates collected from urban air and automobile exhausts in a dose-dependent manner, and that the AHH activity is inducible by five polycyclic aromatic hydrocarbons (PAHs) including 1-/3-nitrobenzo[a]pyrene and 6-chlorochrysene, all present in extracts of particulates from urban air and automobile exhausts. Polycyclic Aromatic Hydrocarbons 232-264 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 198-201 2446793-3 1988 The results demonstrate that AHH activity in the H4IIE cell line can be induced by extracts of particulates collected from urban air and automobile exhausts in a dose-dependent manner, and that the AHH activity is inducible by five polycyclic aromatic hydrocarbons (PAHs) including 1-/3-nitrobenzo[a]pyrene and 6-chlorochrysene, all present in extracts of particulates from urban air and automobile exhausts. Polycyclic Aromatic Hydrocarbons 266-270 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 29-32 2446793-3 1988 The results demonstrate that AHH activity in the H4IIE cell line can be induced by extracts of particulates collected from urban air and automobile exhausts in a dose-dependent manner, and that the AHH activity is inducible by five polycyclic aromatic hydrocarbons (PAHs) including 1-/3-nitrobenzo[a]pyrene and 6-chlorochrysene, all present in extracts of particulates from urban air and automobile exhausts. Polycyclic Aromatic Hydrocarbons 266-270 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 198-201 3335044-1 1988 Two major specific carcinogen-binding proteins are thought to be involved in the regulation of hepatic cytochrome P-4501A1 induction in response to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 148-180 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 103-122 3689794-1 1987 Consideration of the computer-optimised dimensions of anthraflavic acid indicates that it is essentially a planar molecule with a large area/depth ratio, that would preferentially interact with the polycyclic aromatic hydrocarbon-induced family of cytochrome P-450 proteins (cytochromes P-448). Polycyclic Aromatic Hydrocarbons 198-229 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 248-264 3691449-4 1987 Both main-stream and side-stream cigarette smoke condensates and some fractions, containing water-soluble bases, water-insoluble bases, and polycyclic aromatic hydrocarbons, were found to induce AHH activity in lung and liver, the lung being induced to the greatest extent. Polycyclic Aromatic Hydrocarbons 140-172 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 195-198 2827463-1 1988 The cytochrome P-450 monooxygenase system possesses catalytic activity toward many exogenous compounds (e.g., drugs, insecticides, and polycyclic aromatic hydrocarbons) and endogenous compounds (e.g., steroids, fatty acids, and prostaglandins). Polycyclic Aromatic Hydrocarbons 135-167 cytochrome P450 family 20 subfamily A member 1 Homo sapiens 4-34 3120356-2 1987 The CBP binds numerous polycyclic aromatic hydrocarbons, regulates the expression of cytochrome P-450c and is a carrier protein of carcinogen metabolites. Polycyclic Aromatic Hydrocarbons 23-55 CREB binding protein Mus musculus 4-7 2825598-1 1987 The induction of cytochrome P-450c, the isozyme most closely associated with aryl hydrocarbon hydroxylase activity in the rat, is mediated through a cytosolic polycyclic aromatic hydrocarbon (PAH)-binding protein(s). Polycyclic Aromatic Hydrocarbons 159-190 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 17-34 2825598-1 1987 The induction of cytochrome P-450c, the isozyme most closely associated with aryl hydrocarbon hydroxylase activity in the rat, is mediated through a cytosolic polycyclic aromatic hydrocarbon (PAH)-binding protein(s). Polycyclic Aromatic Hydrocarbons 192-195 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 17-34 3689370-3 1987 In this study HHR were found to possess cytochrome P-450-dependent 7-ethoxyresorufin-O-deethylase (ERD) activity which measures cytochrome P-450 isoenzymes that are highly specific (in the order of greater than 95%) markers for the metabolic activation of many environmental carcinogenic substances such as the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 311-343 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-56 3689370-3 1987 In this study HHR were found to possess cytochrome P-450-dependent 7-ethoxyresorufin-O-deethylase (ERD) activity which measures cytochrome P-450 isoenzymes that are highly specific (in the order of greater than 95%) markers for the metabolic activation of many environmental carcinogenic substances such as the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 311-343 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 128-144 3689370-3 1987 In this study HHR were found to possess cytochrome P-450-dependent 7-ethoxyresorufin-O-deethylase (ERD) activity which measures cytochrome P-450 isoenzymes that are highly specific (in the order of greater than 95%) markers for the metabolic activation of many environmental carcinogenic substances such as the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 345-349 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-56 3689370-3 1987 In this study HHR were found to possess cytochrome P-450-dependent 7-ethoxyresorufin-O-deethylase (ERD) activity which measures cytochrome P-450 isoenzymes that are highly specific (in the order of greater than 95%) markers for the metabolic activation of many environmental carcinogenic substances such as the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 345-349 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 128-144 2821631-3 1987 All of the dedifferentiated variants expressed inducible cytochrome P-450c mRNA and AHH activity following treatment with polycyclic aromatic hydrocarbons or the compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polycyclic Aromatic Hydrocarbons 122-154 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 57-74 2821631-3 1987 All of the dedifferentiated variants expressed inducible cytochrome P-450c mRNA and AHH activity following treatment with polycyclic aromatic hydrocarbons or the compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polycyclic Aromatic Hydrocarbons 122-154 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 84-87 3608349-5 1987 The data indicate that a urinary metabolite ratio based on paraxanthine 7-demethylation/8-hydroxylation products reflects systemic caffeine clearance and likely monitors cytochrome P-450 activity inducible by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 209-241 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 170-186 3587745-3 1987 In order to characterize the cytochrome P-450 dependent aryl hydrocarbon hydroxylase activity in brain subcellular fractions, we used 7-ethoxyresorufin as a substrate, as its O-deethylation reflects specifically the activity of the cytochrome P-450 isoform which metabolizes and is induced by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 293-325 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 29-45 2882985-0 1987 Biotransformation of caffeine, paraxanthine, theophylline, and theobromine by polycyclic aromatic hydrocarbon-inducible cytochrome(s) P-450 in human liver microsomes. Polycyclic Aromatic Hydrocarbons 78-109 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 134-139 2882985-3 1987 It appears that the high affinity enzyme is a polycyclic aromatic hydrocarbon-inducible isozyme of cytochrome P-450, based on competitive inhibition by 7-ethoxyresorufin and benzo[a]pyrene, and based on a significant (p less than 0.001) correlation between 7-ethoxyresorufin-O-deethylation and methylxanthine demethylation rates. Polycyclic Aromatic Hydrocarbons 46-77 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 99-115 3542192-11 1987 Using the radiochemical method, dihydrodiol dehydrogenase activity was detected in extrahepatic sites of polycyclic aromatic hydro-carbon metabolism: lung greater than small intestine greater than testis greater than bladder greater than prostate. Polycyclic Aromatic Hydrocarbons 105-137 dihydrodiol dehydrogenase Rattus norvegicus 32-57 3664959-1 1987 In prior studies with neonatal rats we have suggested that nitrated polycyclic aromatic hydrocarbons (NPAH) are 3-methylcholanthrene (3-MC) type of inducers of cytochrome P-450. Polycyclic Aromatic Hydrocarbons 68-100 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 160-176 3593412-5 1987 7-Ethoxyresorufin and acetanilide, selective substrates for two polycyclic aromatic hydrocarbon (PAH)-inducible isozymes of cytochrome P-450 in the mouse (P1-450 and P3-450, respectively) were each able to inhibit competitively the formation of caffeine metabolites by human liver microsomes, while caffeine could in turn similarly inhibit the biotransformations of these two compounds. Polycyclic Aromatic Hydrocarbons 64-95 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 124-140 3593412-5 1987 7-Ethoxyresorufin and acetanilide, selective substrates for two polycyclic aromatic hydrocarbon (PAH)-inducible isozymes of cytochrome P-450 in the mouse (P1-450 and P3-450, respectively) were each able to inhibit competitively the formation of caffeine metabolites by human liver microsomes, while caffeine could in turn similarly inhibit the biotransformations of these two compounds. Polycyclic Aromatic Hydrocarbons 97-100 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 124-140 3593412-8 1987 Taken together, the data support suggestions from in vivo studies that a PAH-inducible isozyme of cytochrome P-450 plays a significant role in the biotransformation of caffeine in man. Polycyclic Aromatic Hydrocarbons 73-76 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 98-114 3557795-4 1987 The identified PAH have been fluoranthene (FLA), pyrene (PYR), benzo(a)anthracene (BaA), chrysene (CHR), benzo(b)fluoranthene (BbF), benzo(k)fluoranthene (BkF), benzo(a)pyrene (BaP), benzo(e)pyrene (BeP) and benzo(ghi)perylene (B(ghi)P). Polycyclic Aromatic Hydrocarbons 15-18 growth hormone receptor Homo sapiens 208-236 3557797-1 1987 Constant decay of polycyclic aromatic hydrocarbons (PAHs) adsorbed onto airborne particulate collected in glass fibre filters and exposed to sunlight ranged from 1.8 to 4.4 X 10(-3) (min-1), corresponding respectively to a half-life of 100 and 425 min. Polycyclic Aromatic Hydrocarbons 18-50 CD59 molecule (CD59 blood group) Homo sapiens 183-188 3557797-1 1987 Constant decay of polycyclic aromatic hydrocarbons (PAHs) adsorbed onto airborne particulate collected in glass fibre filters and exposed to sunlight ranged from 1.8 to 4.4 X 10(-3) (min-1), corresponding respectively to a half-life of 100 and 425 min. Polycyclic Aromatic Hydrocarbons 52-56 CD59 molecule (CD59 blood group) Homo sapiens 183-188 3016738-0 1986 Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 67-99 Harvey rat sarcoma virus oncogene Mus musculus 19-25 3713815-1 1986 Several nitrated polycyclic aromatic hydrocarbons (nitro-PAH) are direct-acting mutagens and/or carcinogens, and are important constituents of combustion emissions and ambient air. Polycyclic Aromatic Hydrocarbons 17-49 Henna Drosophila melanogaster 57-60 2870681-0 1986 Regulation of cytochrome P-450c by glucocorticoids and polycyclic aromatic hydrocarbons in cultured fetal rat hepatocytes. Polycyclic Aromatic Hydrocarbons 55-87 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 14-31 2870681-1 1986 The actions of polycyclic aromatic hydrocarbons and glucocorticoids to regulate the synthesis of cytochrome P-450c (the major isozyme induced by polycyclic aromatic hydrocarbons) were investigated in fetal rat hepatocytes maintained in primary monolayer culture. Polycyclic Aromatic Hydrocarbons 15-47 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 97-114 2870681-1 1986 The actions of polycyclic aromatic hydrocarbons and glucocorticoids to regulate the synthesis of cytochrome P-450c (the major isozyme induced by polycyclic aromatic hydrocarbons) were investigated in fetal rat hepatocytes maintained in primary monolayer culture. Polycyclic Aromatic Hydrocarbons 145-177 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 97-114 2870681-9 1986 The concentration of dexamethasone required to cause a half-maximal increase in P-450c content in the presence of 1,2-benzanthracene was between 10(-8) and 10(-7) M. It is concluded that glucocorticoids act synergistically with polycyclic aromatic hydrocarbons to increase the levels of P-450c expressed in the fetal rat liver, and that this action is likely mediated by the classical type II glucocorticoid receptor. Polycyclic Aromatic Hydrocarbons 228-260 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 80-86 3011254-14 1986 Aryl hydrocarbon hydroxylase, the major enzyme induced under control of the Ah receptor, plays an important role in the metabolism of several carcinogens including polycyclic aromatic hydrocarbons such as benzo(a)pyrene. Polycyclic Aromatic Hydrocarbons 164-196 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 0-28 3011254-14 1986 Aryl hydrocarbon hydroxylase, the major enzyme induced under control of the Ah receptor, plays an important role in the metabolism of several carcinogens including polycyclic aromatic hydrocarbons such as benzo(a)pyrene. Polycyclic Aromatic Hydrocarbons 164-196 aryl hydrocarbon receptor Homo sapiens 76-87 3087025-0 1986 Protection by uridine diphosphoglucuronic acid and DT-diaphorase against the cytotoxicity of polycyclic aromatic hydrocarbons isolated from a complex coal gasification condensate. Polycyclic Aromatic Hydrocarbons 93-125 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 51-64 3087025-3 1986 Rat liver cytosol, semipurified DT-diaphorase, and uridine diphosphoglucuronic acid decreased the cytotoxicity of a variety of PAH mixtures and representative PAH, as well as individual PAH metabolites. Polycyclic Aromatic Hydrocarbons 127-130 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 32-45 3087025-3 1986 Rat liver cytosol, semipurified DT-diaphorase, and uridine diphosphoglucuronic acid decreased the cytotoxicity of a variety of PAH mixtures and representative PAH, as well as individual PAH metabolites. Polycyclic Aromatic Hydrocarbons 159-162 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 32-45 3087025-3 1986 Rat liver cytosol, semipurified DT-diaphorase, and uridine diphosphoglucuronic acid decreased the cytotoxicity of a variety of PAH mixtures and representative PAH, as well as individual PAH metabolites. Polycyclic Aromatic Hydrocarbons 159-162 NAD(P)H quinone dehydrogenase 1 Rattus norvegicus 32-45 3085967-9 1986 These results provide a first demonstration that hydroxylation of a PAH can lead to preferential metabolism through an increased affinity for cytochrome P-450. Polycyclic Aromatic Hydrocarbons 68-71 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 142-158 3004505-12 1986 The PAH produced a 2-fold increase in spectroscopically detectable cytochrome P-450 levels in NCI-H322. Polycyclic Aromatic Hydrocarbons 4-7 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 67-83 4096145-13 1985 The separation of the neutral compounds into AlP, PAH and POCN showed a higher amount of AlP at the collecting station which includes mainly automobile traffic. Polycyclic Aromatic Hydrocarbons 50-53 ATHS Homo sapiens 89-92 3790107-0 1986 The molecular biology of the polycyclic aromatic hydrocarbon inducible cytochrome P-450; the past is prologue. Polycyclic Aromatic Hydrocarbons 29-60 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 71-87 4084307-2 1985 The Ya" and Yc-type subunits of rat lung GST exhibit maximum activities towards BP-4,5-oxide and BP-7,8-oxide suggesting that these two subunits are preferentially involved in the detoxification of highly reactive epoxides and diol-epoxides of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 244-276 hematopoietic prostaglandin D synthase Rattus norvegicus 41-44 4084307-2 1985 The Ya" and Yc-type subunits of rat lung GST exhibit maximum activities towards BP-4,5-oxide and BP-7,8-oxide suggesting that these two subunits are preferentially involved in the detoxification of highly reactive epoxides and diol-epoxides of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 244-276 Blood pressure QTL 4 Rattus norvegicus 80-84 4084307-2 1985 The Ya" and Yc-type subunits of rat lung GST exhibit maximum activities towards BP-4,5-oxide and BP-7,8-oxide suggesting that these two subunits are preferentially involved in the detoxification of highly reactive epoxides and diol-epoxides of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 244-276 Blood pressure QTL 7 Rattus norvegicus 97-101 4084307-2 1985 The Ya" and Yc-type subunits of rat lung GST exhibit maximum activities towards BP-4,5-oxide and BP-7,8-oxide suggesting that these two subunits are preferentially involved in the detoxification of highly reactive epoxides and diol-epoxides of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 278-281 hematopoietic prostaglandin D synthase Rattus norvegicus 41-44 4084307-2 1985 The Ya" and Yc-type subunits of rat lung GST exhibit maximum activities towards BP-4,5-oxide and BP-7,8-oxide suggesting that these two subunits are preferentially involved in the detoxification of highly reactive epoxides and diol-epoxides of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 278-281 Blood pressure QTL 4 Rattus norvegicus 80-84 4084307-2 1985 The Ya" and Yc-type subunits of rat lung GST exhibit maximum activities towards BP-4,5-oxide and BP-7,8-oxide suggesting that these two subunits are preferentially involved in the detoxification of highly reactive epoxides and diol-epoxides of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 278-281 Blood pressure QTL 7 Rattus norvegicus 97-101 4084307-4 1985 Identification of compounds which can selectively induce these isoenzymes of GST could prove useful as inhibitors of PAH induced neoplasia. Polycyclic Aromatic Hydrocarbons 117-120 glutathione S-transferase kappa 1 Homo sapiens 77-80 6435901-3 1984 Cytochrome P-450d, a minor MC-inducible form, has far lower activity for metabolism of both polycyclic aromatic hydrocarbons (PAH), yet also forms high affinity complexes (Kd approximately 100 nM) with both PAH, retaining the full high spin state of the free cytochrome. Polycyclic Aromatic Hydrocarbons 92-124 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 0-17 3079671-4 1986 Placental microsomes from exposed subjects were found to contain a protein that cross-reacted with antibodies raised to rabbit cytochrome P-450 isozyme 6, an isozyme induced by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 177-209 cytochrome P450 1A1 Oryctolagus cuniculus 127-153 3839750-0 1985 Identification and quantification of a messenger ribonucleic acid induced by polynuclear aromatic hydrocarbons--using a cloned human cytochrome P-450 gene. Polycyclic Aromatic Hydrocarbons 77-110 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 133-149 3839750-2 1985 The form of P-450 most closely associated with polynuclear aromatic hydrocarbons induction has been defined as P1-450. Polycyclic Aromatic Hydrocarbons 47-80 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 111-117 3839750-6 1985 Upon treatment with polynuclear aromatic hydrocarbons there is a positive correlation between induced arylhydrocarbon hydroxylase (flavoprotein-linked monoxygenase) activity and the amount of mRNA that hybridizes to the isolated human genomic clone for P1-450. Polycyclic Aromatic Hydrocarbons 20-53 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 253-259 4059324-0 1985 Modulation of rat hepatic aryl hydrocarbon hydroxylase by various flavones and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 79-111 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 26-54 2983444-1 1985 Properties of the aryl hydrocarbon hydroxylase (AHH) enzyme system were examined in polycyclic aromatic hydrocarbon (PAH) -noninducible L-cell x PAH-inducible hepatoma (Hepa) mouse cell hybrids. Polycyclic Aromatic Hydrocarbons 84-115 aryl-hydrocarbon receptor Mus musculus 48-51 2983444-1 1985 Properties of the aryl hydrocarbon hydroxylase (AHH) enzyme system were examined in polycyclic aromatic hydrocarbon (PAH) -noninducible L-cell x PAH-inducible hepatoma (Hepa) mouse cell hybrids. Polycyclic Aromatic Hydrocarbons 117-120 aryl-hydrocarbon receptor Mus musculus 18-46 2983444-1 1985 Properties of the aryl hydrocarbon hydroxylase (AHH) enzyme system were examined in polycyclic aromatic hydrocarbon (PAH) -noninducible L-cell x PAH-inducible hepatoma (Hepa) mouse cell hybrids. Polycyclic Aromatic Hydrocarbons 117-120 aryl-hydrocarbon receptor Mus musculus 48-51 2983444-1 1985 Properties of the aryl hydrocarbon hydroxylase (AHH) enzyme system were examined in polycyclic aromatic hydrocarbon (PAH) -noninducible L-cell x PAH-inducible hepatoma (Hepa) mouse cell hybrids. Polycyclic Aromatic Hydrocarbons 145-148 aryl-hydrocarbon receptor Mus musculus 18-46 2983444-1 1985 Properties of the aryl hydrocarbon hydroxylase (AHH) enzyme system were examined in polycyclic aromatic hydrocarbon (PAH) -noninducible L-cell x PAH-inducible hepatoma (Hepa) mouse cell hybrids. Polycyclic Aromatic Hydrocarbons 145-148 aryl-hydrocarbon receptor Mus musculus 48-51 6435901-3 1984 Cytochrome P-450d, a minor MC-inducible form, has far lower activity for metabolism of both polycyclic aromatic hydrocarbons (PAH), yet also forms high affinity complexes (Kd approximately 100 nM) with both PAH, retaining the full high spin state of the free cytochrome. Polycyclic Aromatic Hydrocarbons 126-129 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 0-17 6435901-3 1984 Cytochrome P-450d, a minor MC-inducible form, has far lower activity for metabolism of both polycyclic aromatic hydrocarbons (PAH), yet also forms high affinity complexes (Kd approximately 100 nM) with both PAH, retaining the full high spin state of the free cytochrome. Polycyclic Aromatic Hydrocarbons 207-210 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 0-17 6435901-8 1984 P-450b remains low spin in the presence of PAH and NOA is again not displaced. Polycyclic Aromatic Hydrocarbons 43-46 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 0-6 6514434-3 1984 We hypothesized that increased aryl hydrocarbon hydroxylase (AHH) activity observed in placentas from smokers might help clear PAHs from maternal circulation and thereby prevent transplacental induction of AHH by PAHs. Polycyclic Aromatic Hydrocarbons 213-217 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 61-64 6514434-3 1984 We hypothesized that increased aryl hydrocarbon hydroxylase (AHH) activity observed in placentas from smokers might help clear PAHs from maternal circulation and thereby prevent transplacental induction of AHH by PAHs. Polycyclic Aromatic Hydrocarbons 127-131 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 31-59 6514434-3 1984 We hypothesized that increased aryl hydrocarbon hydroxylase (AHH) activity observed in placentas from smokers might help clear PAHs from maternal circulation and thereby prevent transplacental induction of AHH by PAHs. Polycyclic Aromatic Hydrocarbons 127-131 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 61-64 6514434-3 1984 We hypothesized that increased aryl hydrocarbon hydroxylase (AHH) activity observed in placentas from smokers might help clear PAHs from maternal circulation and thereby prevent transplacental induction of AHH by PAHs. Polycyclic Aromatic Hydrocarbons 213-217 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 31-59 6514434-3 1984 We hypothesized that increased aryl hydrocarbon hydroxylase (AHH) activity observed in placentas from smokers might help clear PAHs from maternal circulation and thereby prevent transplacental induction of AHH by PAHs. Polycyclic Aromatic Hydrocarbons 213-217 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 206-209 6088514-3 1984 Treatment of the cells with the polycyclic aromatic hydrocarbons, benzo(a)pyrene (BaP) or dimethylbenzanthracene, at concentrations which do not affect cell growth or macromolecular synthesis, stimulates the production of hCG in these cells. Polycyclic Aromatic Hydrocarbons 32-64 chorionic gonadotropin subunit beta 5 Homo sapiens 222-225 6496065-1 1984 There is considerable evidence that the inducible enzyme aryl hydrocarbon hydroxylase (AHH) plays an important role in the activation of polycyclic aromatic hydrocarbons (PAH) to ultimate carcinogens. Polycyclic Aromatic Hydrocarbons 137-169 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 57-85 6496065-1 1984 There is considerable evidence that the inducible enzyme aryl hydrocarbon hydroxylase (AHH) plays an important role in the activation of polycyclic aromatic hydrocarbons (PAH) to ultimate carcinogens. Polycyclic Aromatic Hydrocarbons 137-169 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 87-90 6496065-1 1984 There is considerable evidence that the inducible enzyme aryl hydrocarbon hydroxylase (AHH) plays an important role in the activation of polycyclic aromatic hydrocarbons (PAH) to ultimate carcinogens. Polycyclic Aromatic Hydrocarbons 171-174 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 57-85 6496065-1 1984 There is considerable evidence that the inducible enzyme aryl hydrocarbon hydroxylase (AHH) plays an important role in the activation of polycyclic aromatic hydrocarbons (PAH) to ultimate carcinogens. Polycyclic Aromatic Hydrocarbons 171-174 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 87-90 6496065-2 1984 In man, a genetic heterogeneity of AHH inducibility has been demonstrated, and correlated to susceptibility to bronchogenic carcinomas following exposure to PAH. Polycyclic Aromatic Hydrocarbons 157-160 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 35-38 6496065-7 1984 These findings add further support to the concept that susceptibility to PAH-induced carcinomas is associated with high levels of inducible AHH activity. Polycyclic Aromatic Hydrocarbons 73-76 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 140-143 7120116-3 1982 In vitro treatment of the cells or in vivo application to the skin of animals with the polycyclic aromatic hydrocarbons benz(a)anthracene (BA) or benzo(a)pyrene resulted in significant induction of AHH and 7-ED activities. Polycyclic Aromatic Hydrocarbons 87-119 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 198-201 6591898-1 1984 Animal studies have linked aryl hydrocarbon hydroxylase (AHH) with cancer induction by polycyclic aromatic hydrocarbons (PAH), but the relationship between the activation of PAH by AHH and cancer induction in man is unclear. Polycyclic Aromatic Hydrocarbons 87-119 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 27-55 6591898-1 1984 Animal studies have linked aryl hydrocarbon hydroxylase (AHH) with cancer induction by polycyclic aromatic hydrocarbons (PAH), but the relationship between the activation of PAH by AHH and cancer induction in man is unclear. Polycyclic Aromatic Hydrocarbons 87-119 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 57-60 6591898-1 1984 Animal studies have linked aryl hydrocarbon hydroxylase (AHH) with cancer induction by polycyclic aromatic hydrocarbons (PAH), but the relationship between the activation of PAH by AHH and cancer induction in man is unclear. Polycyclic Aromatic Hydrocarbons 121-124 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 27-55 6591898-1 1984 Animal studies have linked aryl hydrocarbon hydroxylase (AHH) with cancer induction by polycyclic aromatic hydrocarbons (PAH), but the relationship between the activation of PAH by AHH and cancer induction in man is unclear. Polycyclic Aromatic Hydrocarbons 121-124 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 57-60 6591898-1 1984 Animal studies have linked aryl hydrocarbon hydroxylase (AHH) with cancer induction by polycyclic aromatic hydrocarbons (PAH), but the relationship between the activation of PAH by AHH and cancer induction in man is unclear. Polycyclic Aromatic Hydrocarbons 174-177 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 57-60 6591898-1 1984 Animal studies have linked aryl hydrocarbon hydroxylase (AHH) with cancer induction by polycyclic aromatic hydrocarbons (PAH), but the relationship between the activation of PAH by AHH and cancer induction in man is unclear. Polycyclic Aromatic Hydrocarbons 174-177 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 181-184 6511802-3 1984 The results add further support to the concept of AHH as a major activator of carcinogens belonging to the group of polycyclic aromatic hydrocarbons (PAH) when these affect the oral cavity and/or the respiratory tract. Polycyclic Aromatic Hydrocarbons 116-148 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 50-53 6511802-3 1984 The results add further support to the concept of AHH as a major activator of carcinogens belonging to the group of polycyclic aromatic hydrocarbons (PAH) when these affect the oral cavity and/or the respiratory tract. Polycyclic Aromatic Hydrocarbons 150-153 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 50-53 6640544-2 1983 Twenty polycyclic aromatic hydrocarbons were screened for phototoxicity and toxicity in the absence of light in the mouse hepatoma line Hepa1c1c7, which has high inducible aryl hydrocarbon hydroxylase (AHH) activity, and in AHH-deficient mutants derived from this line. Polycyclic Aromatic Hydrocarbons 7-39 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 202-205 6625610-8 1983 Competition studies showed that these proteins were not steroid receptors, and that only polycyclic aromatic hydrocarbons which could induce cytochrome P-450c were able to displace 3-methylcholanthrene from the binding site. Polycyclic Aromatic Hydrocarbons 89-121 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 141-158 6337829-6 1983 So far the studies carried out among the Finnish working population exposed to PAH compounds reveal an association between the lung cancer risk and exposure to PAHs. Polycyclic Aromatic Hydrocarbons 160-164 phenylalanine hydroxylase Homo sapiens 79-82 3924465-13 1985 To understand the mechanism of PAH-induced immunotoxicity, splenocytes from DMBA-exposed mice were sensitized to alloantigens in the presence of interleukin-2 (IL-2) because there were indications that T-helper cell function was suppressed. Polycyclic Aromatic Hydrocarbons 31-34 interleukin 2 Mus musculus 145-158 3924465-13 1985 To understand the mechanism of PAH-induced immunotoxicity, splenocytes from DMBA-exposed mice were sensitized to alloantigens in the presence of interleukin-2 (IL-2) because there were indications that T-helper cell function was suppressed. Polycyclic Aromatic Hydrocarbons 31-34 interleukin 2 Mus musculus 160-164 6538589-5 1984 The rapid biotransformation of arene oxides such as BP-4,5-oxide in the skin emphasizes the potential importance of epoxide hydrolase in the activation and inactivation of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 172-204 Blood pressure QTL 4 Rattus norvegicus 52-56 6630514-10 1983 These data indicate that the C-2 and C-16 oxidations of estradiol take place in cultured avian hepatocytes and that the extent of metabolism at these positions on the hormone molecule can be altered by chemicals, such as drugs and polycyclic aromatic hydrocarbons, which induce distinctive species of cytochrome P-450 in the liver. Polycyclic Aromatic Hydrocarbons 231-263 complement C2 Gallus gallus 29-32 6630514-10 1983 These data indicate that the C-2 and C-16 oxidations of estradiol take place in cultured avian hepatocytes and that the extent of metabolism at these positions on the hormone molecule can be altered by chemicals, such as drugs and polycyclic aromatic hydrocarbons, which induce distinctive species of cytochrome P-450 in the liver. Polycyclic Aromatic Hydrocarbons 231-263 galectin 1B Gallus gallus 37-41 6366402-2 1983 Polycyclic aromatic hydrocarbons present in cigarette smoke induce hepatic aryl hydrocarbon hydroxylase and cytochrome P448 and increased levels of these enzymes are responsible for a higher metabolic clearance of drugs which are substrates for these enzymes. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 75-103 6638486-2 1983 Two of the ethylfluoresceins are specifically metabolized by the polycyclic aromatic hydrocarbon inducible cytochrome P-450 to yield fluorescein, which is about 15 times more fluorescent than the ethylated compounds. Polycyclic Aromatic Hydrocarbons 65-96 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 107-123 6182644-0 1982 Differential induction of UDP glucuronosyltransferase activities towards various substrates after polycyclic aromatic hydrocarbon administration to rats. Polycyclic Aromatic Hydrocarbons 98-129 UDP glycosyltransferase 2 family, polypeptide B Rattus norvegicus 26-53 6279279-6 1982 Thus, the PGS system appears to be more selective than does the cytochrome P-450 system in the activation of polycyclic aromatic hydrocarbons to mutagenic products, activating only those dihydrodiols with adjacent double bonds in the bay region from which the bay-region diol-epoxides are formed. Polycyclic Aromatic Hydrocarbons 109-141 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 64-80 17842405-1 1982 The existence of an internal hydrogen bond in a compound representative of a syn diol epoxide (a possible intermediate in chemical carcinogenesis by certain polycyclic aromatic hydrocarbons) has been demonstrated by x-ray crystallographic and nuclear magnetic resonance studies. Polycyclic Aromatic Hydrocarbons 157-189 synemin Homo sapiens 77-80 6320220-0 1983 Competitive interaction for the Ah receptor by polycyclic aromatic hydrocarbons which do not induce aryl hydrocarbon hydroxylase in C3H/10T1/2 mouse embryo fibroblasts. Polycyclic Aromatic Hydrocarbons 47-79 aryl-hydrocarbon receptor Mus musculus 32-43 6800653-7 1982 The adrenal cytochrome P-450 involved in the conversion of these polycyclic aromatic hydrocarbons appears to be unrelated to those responsible for the synthesis of mineralocorticoids and glucocorticoids from cholesterol. Polycyclic Aromatic Hydrocarbons 65-97 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 12-28 6291004-1 1982 Induction of aryl hydrocarbon hydroxylase (AHH) by polycyclic aromatic hydrocarbons and other inducers such as 2,3,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to occur following binding of the inducer to a soluble receptor protein similar to steroid hormone receptors. Polycyclic Aromatic Hydrocarbons 51-83 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 13-41 6291004-1 1982 Induction of aryl hydrocarbon hydroxylase (AHH) by polycyclic aromatic hydrocarbons and other inducers such as 2,3,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to occur following binding of the inducer to a soluble receptor protein similar to steroid hormone receptors. Polycyclic Aromatic Hydrocarbons 51-83 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 43-46 7332631-4 1981 These findings suggest that AHH induction in man may be "systematically" regulated and that the genetic background will determine the extent of induction at a given level of exposure to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 186-218 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 28-31 6786734-2 1981 The major structural features are: (a) the adenine and polycyclic aromatic hydrocarbon residues lie nearly perpendicular to one another; (b) the conformation about the glycosidic bond is syn, rather than anti, and an internal hydrogen bond between the deoxyribose 5"-hydroxyl group and N(3) of the adenine residue is present; and (c) the more planar anthracene portion of the hydrocarbon is stacked between adenine residues of other molecules throughout the crystal. Polycyclic Aromatic Hydrocarbons 55-86 synemin Homo sapiens 187-190 991864-2 1976 A general assay for epoxide hydratase using epoxides derived from polycyclic aromatic hydrocarbons as substrates is described. Polycyclic Aromatic Hydrocarbons 66-98 epoxide hydrolase 2 Rattus norvegicus 20-37 6284402-1 1982 The binding of 125I-labelled epidermal growth factor (EGF) was utilized to monitor possible cell surface effects of polycyclic aromatic hydrocarbon carcinogens. Polycyclic Aromatic Hydrocarbons 116-147 epidermal growth factor Mus musculus 29-52 6284402-1 1982 The binding of 125I-labelled epidermal growth factor (EGF) was utilized to monitor possible cell surface effects of polycyclic aromatic hydrocarbon carcinogens. Polycyclic Aromatic Hydrocarbons 116-147 epidermal growth factor Mus musculus 54-57 6284402-10 1982 We postulate that the binding of certain polycyclic aromatic hydrocarbons to the Ah receptor may induce not only specific drug metabolizing enzymes but also inhibition of EGF binding, and possible other cell effects. Polycyclic Aromatic Hydrocarbons 41-73 aryl-hydrocarbon receptor Mus musculus 81-92 6284402-10 1982 We postulate that the binding of certain polycyclic aromatic hydrocarbons to the Ah receptor may induce not only specific drug metabolizing enzymes but also inhibition of EGF binding, and possible other cell effects. Polycyclic Aromatic Hydrocarbons 41-73 epidermal growth factor Mus musculus 171-174 7344478-0 1981 Regio- and stereoselectivity of hepatic cytochrome P-450 toward polycyclic aromatic hydrocarbon substrates. Polycyclic Aromatic Hydrocarbons 64-95 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-56 7344478-1 1981 Although the cytochrome P-450 system shows broad substrate specificity toward the PAH, it also has regio- and stereoselectivity. Polycyclic Aromatic Hydrocarbons 82-85 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 13-29 7464853-5 1980 One source of Swiss mouse liver (Blu : Ha ICR) provided the most active S9 when tested with the 3 polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 98-130 zinc finger, MYND domain containing 10 Mus musculus 33-36 6105054-6 1980 This poor correlation was caused mainly by the nonequal effects of polycyclic aromatic hydrocarbons on cytochrome P-450 and aryl hydrocarbon hydroxylase. Polycyclic Aromatic Hydrocarbons 67-99 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 103-152 7358110-1 1980 Type II alveolar lung cells metabolize polycyclic aromatic hydrocarbons as indicated by measurements of aryl hydrocarbon hydroxylase activity and binding of tritium labeled benzo(a)pyrene to nuclear and cytoplasmic components. Polycyclic Aromatic Hydrocarbons 39-71 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 104-132 509418-6 1979 Thus, the inhibition by caffeine of the binding of polycyclic aromatic hydrocarbons (PAH) to DNA may be related to its effect on AHH. Polycyclic Aromatic Hydrocarbons 51-83 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 129-132 509418-6 1979 Thus, the inhibition by caffeine of the binding of polycyclic aromatic hydrocarbons (PAH) to DNA may be related to its effect on AHH. Polycyclic Aromatic Hydrocarbons 85-88 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 129-132 115598-1 1979 Rat mammary epithelial cells grown in primary culture contain the microsomal enzyme, aryl hydrocarbon (benzo[a]pyrene) hydroxylase (AHH), which catalyses the oxidative conversion of polycyclic aromatic hydrocarbons (PAH) to more polar derivatives. Polycyclic Aromatic Hydrocarbons 182-214 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 132-135 115598-1 1979 Rat mammary epithelial cells grown in primary culture contain the microsomal enzyme, aryl hydrocarbon (benzo[a]pyrene) hydroxylase (AHH), which catalyses the oxidative conversion of polycyclic aromatic hydrocarbons (PAH) to more polar derivatives. Polycyclic Aromatic Hydrocarbons 216-219 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 132-135 509413-2 1979 These cells contain aryl hydrocarbon hydroxylase (AHH) as determined by fluorescent measurements of water-soluble product from the metabolism of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 145-177 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 20-48 509413-2 1979 These cells contain aryl hydrocarbon hydroxylase (AHH) as determined by fluorescent measurements of water-soluble product from the metabolism of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 145-177 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 50-53 509413-2 1979 These cells contain aryl hydrocarbon hydroxylase (AHH) as determined by fluorescent measurements of water-soluble product from the metabolism of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 179-182 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 20-48 509413-2 1979 These cells contain aryl hydrocarbon hydroxylase (AHH) as determined by fluorescent measurements of water-soluble product from the metabolism of polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 179-182 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 50-53 1447-1 1976 Mouse skin contains a NADPH-dependent, aryl hydrocarbon hydroxylase (AHH), which is inducible by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 97-129 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 39-67 1447-1 1976 Mouse skin contains a NADPH-dependent, aryl hydrocarbon hydroxylase (AHH), which is inducible by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 97-129 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 69-72 1192552-1 1975 A close correlation has been observed between the ability of aromatic polycyclic hydrocarbons and 7,8-benzoflavone (7,8-BF) to induce hepatic aryl hydrocarbon hydroxylase (AHH) in vivo and to inhibit the induced enzyme system in vitro. Polycyclic Aromatic Hydrocarbons 61-93 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 142-170 1192552-1 1975 A close correlation has been observed between the ability of aromatic polycyclic hydrocarbons and 7,8-benzoflavone (7,8-BF) to induce hepatic aryl hydrocarbon hydroxylase (AHH) in vivo and to inhibit the induced enzyme system in vitro. Polycyclic Aromatic Hydrocarbons 61-93 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 172-175 1060073-10 1975 The positional specificities of different forms of cytochrome P-450 may channel polycyclic aromatic hydrocarbon metabolism into the various activation and detoxification pathways and thereby help determine the cytotoxic and carcinogenic activity of these compounds. Polycyclic Aromatic Hydrocarbons 80-111 cytochrome P-450 Oryctolagus cuniculus 51-67 6279326-13 1982 This study demonstrates the unique positional specificity of different forms of cytochrome P-450 which may regulate the balance between activation and detoxification pathways of polycyclic aromatic hydrocarbon metabolism. Polycyclic Aromatic Hydrocarbons 178-209 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 80-96 7226148-0 1980 Specificity of mouse liver cytosolic epoxide hydrolase for K-region epoxides derived from polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 90-122 epoxide hydrolase 2, cytoplasmic Mus musculus 27-54 476610-7 1979 These AS-PAH complexes are capable of inducing AHH in cultured human lymphocytes. Polycyclic Aromatic Hydrocarbons 9-12 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 47-50 19847983-2 1979 The effect of temperature variations on the thermodynamic distribution behaviour in a silica C18/aqueous acetonitrile chromatographic system of polynuclear aromatic hydrocarbons is discussed. Polycyclic Aromatic Hydrocarbons 144-177 Bardet-Biedl syndrome 9 Homo sapiens 93-96 222079-4 1979 However, cytochrome P(1)-450, a form of the hemoprotein induced by polycyclic aromatic hydrocarbons, was resistant to this change. Polycyclic Aromatic Hydrocarbons 67-99 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 9-28 134910-5 1976 The administration of polycyclic aromatic hydrocarbons (e.g., 3-methylcholanthrene (MC)) to certain inbred strains of mice induces aryl hydrocarbon hydroxylase, while other inbred strains fail to respond; and the trait of aryl hydrocarbon responsiveness is inherited as an autosomal dominant. Polycyclic Aromatic Hydrocarbons 22-54 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 131-159 1126004-1 1975 Colloidal dispersions of polycyclic aromatic hydrocarbons were found to inhibit glyceraldehyde-3-phosphate dehydrogenase (GPDH) and lactic acid dehydrogenase (LDH) after a short exposure of the incubation medium to laboratory lighting. Polycyclic Aromatic Hydrocarbons 25-57 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 80-120 1126004-1 1975 Colloidal dispersions of polycyclic aromatic hydrocarbons were found to inhibit glyceraldehyde-3-phosphate dehydrogenase (GPDH) and lactic acid dehydrogenase (LDH) after a short exposure of the incubation medium to laboratory lighting. Polycyclic Aromatic Hydrocarbons 25-57 glyceraldehyde-3-phosphate dehydrogenase Homo sapiens 122-126 33675803-2 2021 These effects may be initiated during a prenatal period of susceptibility to PAH activation of the aryl hydrocarbon receptor (Ahr) and through downstream effects on estrogen receptor (Er) alpha. Polycyclic Aromatic Hydrocarbons 77-80 aryl-hydrocarbon receptor Mus musculus 99-124 4176021-0 1968 [The hydrophobic interaction of polycyclic aromatic hydrocarbons with human serum albumin]. Polycyclic Aromatic Hydrocarbons 32-64 albumin Homo sapiens 82-89 34029822-3 2021 In all the samples, the theoretical BaP-EQs of PAHs (calculated using PAH-CALUX relative potencies) accounted for 28 +- 19% of the CALUX BaP-EQs, suggesting significant contribution of aryl hydrocarbon receptor (AhR) agonists and/or mixture effects. Polycyclic Aromatic Hydrocarbons 47-50 aryl hydrocarbon receptor Homo sapiens 185-210 34029822-3 2021 In all the samples, the theoretical BaP-EQs of PAHs (calculated using PAH-CALUX relative potencies) accounted for 28 +- 19% of the CALUX BaP-EQs, suggesting significant contribution of aryl hydrocarbon receptor (AhR) agonists and/or mixture effects. Polycyclic Aromatic Hydrocarbons 47-50 aryl hydrocarbon receptor Homo sapiens 212-215 33994786-2 2020 In addition, mEH metabolizes polycyclic aromatic hydrocarbons, one of the causative factors of atherosclerotic lesion development. Polycyclic Aromatic Hydrocarbons 29-61 epoxide hydrolase 1, microsomal Mus musculus 13-16 34034407-1 2021 Objective: To investigate the dose-response relationship between serum polycyclic aromatic hydrocarbon adducts and serum complement C3 and C4 levels among children from a city in East China. Polycyclic Aromatic Hydrocarbons 71-102 complement C3 Homo sapiens 121-134 33930972-9 2021 PAH removals in soils CPS and CSG were up to 90.1% and 89.7% with surfactants and co-surfactant (Surf:Co-s), (Surf:Co-s) and FAME, soil and MEs (w:v) at ratios of 1:1, 8:2 and 1:4, respectively. Polycyclic Aromatic Hydrocarbons 0-3 benign adult familial myoclonic epilepsy 1 Homo sapiens 125-129 33607432-0 2021 Past, present, and future perspectives on the assessment of bioavailability/bioaccessibility of polycyclic aromatic hydrocarbons: A 20-year systemic review based on scientific econometrics. Polycyclic Aromatic Hydrocarbons 96-128 EH domain containing 1 Homo sapiens 0-4 33450065-6 2021 The modified C18 column was employed to separate amino acids, alkylbenzenes, polycyclic aromatic hydrocarbons (PAHs) under RPLC mode and inorganic anion under AEC mode. Polycyclic Aromatic Hydrocarbons 77-109 Bardet-Biedl syndrome 9 Homo sapiens 13-16 33450065-6 2021 The modified C18 column was employed to separate amino acids, alkylbenzenes, polycyclic aromatic hydrocarbons (PAHs) under RPLC mode and inorganic anion under AEC mode. Polycyclic Aromatic Hydrocarbons 111-115 Bardet-Biedl syndrome 9 Homo sapiens 13-16 34036706-8 2021 The FL community was enriched in predicted pathways for the metabolism of inositol phosphate, a potential phosphorus source, and of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 132-164 fms related receptor tyrosine kinase 3 ligand Homo sapiens 4-6 33675803-2 2021 These effects may be initiated during a prenatal period of susceptibility to PAH activation of the aryl hydrocarbon receptor (Ahr) and through downstream effects on estrogen receptor (Er) alpha. Polycyclic Aromatic Hydrocarbons 77-80 aryl-hydrocarbon receptor Mus musculus 126-129 33675803-2 2021 These effects may be initiated during a prenatal period of susceptibility to PAH activation of the aryl hydrocarbon receptor (Ahr) and through downstream effects on estrogen receptor (Er) alpha. Polycyclic Aromatic Hydrocarbons 77-80 estrogen receptor 1 (alpha) Mus musculus 165-193 33675803-6 2021 RESULTS: Prenatal ambient PAH exposure lowered Eralpha mRNA expression (F1 and F2: p<0.001 for each) and induced methylation in the Eralpha promoter in mammary tissue in offspring and grandoffspring mice on postnatal day (PND) 60. Polycyclic Aromatic Hydrocarbons 26-29 estrogen receptor 1 (alpha) Mus musculus 47-54 33675803-6 2021 RESULTS: Prenatal ambient PAH exposure lowered Eralpha mRNA expression (F1 and F2: p<0.001 for each) and induced methylation in the Eralpha promoter in mammary tissue in offspring and grandoffspring mice on postnatal day (PND) 60. Polycyclic Aromatic Hydrocarbons 26-29 estrogen receptor 1 (alpha) Mus musculus 132-139 33675803-8 2021 Prenatal PAH lowered Ahrr (F1: p=0.03, F2: p=0.009) and raised Arnt mRNA expression (F1: p=0.01, F2: p=0.03). Polycyclic Aromatic Hydrocarbons 9-12 aryl-hydrocarbon receptor repressor Mus musculus 21-25 33675803-8 2021 Prenatal PAH lowered Ahrr (F1: p=0.03, F2: p=0.009) and raised Arnt mRNA expression (F1: p=0.01, F2: p=0.03). Polycyclic Aromatic Hydrocarbons 9-12 aryl hydrocarbon receptor nuclear translocator Mus musculus 63-67 33675803-12 2021 CONCLUSIONS: Prenatal PAH exposure induces DNA methylation and alters gene expression in the Eralpha-mediated pathway across generations, and suggests that functional outcomes such as mammary cell proliferation also may occur in offspring as a result. Polycyclic Aromatic Hydrocarbons 22-25 estrogen receptor 1 (alpha) Mus musculus 93-100 33319219-1 2021 Although it is well established that human cytochrome P450 1 (CYP1) family enzymes are induced by cigarette smoking through activation of the Ah receptor (AhR), it is not known whether this leads to increased metabolic activation or detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAH), which are present in cigarette smoke and the general environment. Polycyclic Aromatic Hydrocarbons 264-296 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-66 33319219-1 2021 Although it is well established that human cytochrome P450 1 (CYP1) family enzymes are induced by cigarette smoking through activation of the Ah receptor (AhR), it is not known whether this leads to increased metabolic activation or detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAH), which are present in cigarette smoke and the general environment. Polycyclic Aromatic Hydrocarbons 264-296 aryl hydrocarbon receptor Homo sapiens 142-153 33319219-1 2021 Although it is well established that human cytochrome P450 1 (CYP1) family enzymes are induced by cigarette smoking through activation of the Ah receptor (AhR), it is not known whether this leads to increased metabolic activation or detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAH), which are present in cigarette smoke and the general environment. Polycyclic Aromatic Hydrocarbons 264-296 aryl hydrocarbon receptor Homo sapiens 155-158 33319219-1 2021 Although it is well established that human cytochrome P450 1 (CYP1) family enzymes are induced by cigarette smoking through activation of the Ah receptor (AhR), it is not known whether this leads to increased metabolic activation or detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAH), which are present in cigarette smoke and the general environment. Polycyclic Aromatic Hydrocarbons 298-301 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-60 33319219-1 2021 Although it is well established that human cytochrome P450 1 (CYP1) family enzymes are induced by cigarette smoking through activation of the Ah receptor (AhR), it is not known whether this leads to increased metabolic activation or detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAH), which are present in cigarette smoke and the general environment. Polycyclic Aromatic Hydrocarbons 298-301 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-66 33319219-1 2021 Although it is well established that human cytochrome P450 1 (CYP1) family enzymes are induced by cigarette smoking through activation of the Ah receptor (AhR), it is not known whether this leads to increased metabolic activation or detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAH), which are present in cigarette smoke and the general environment. Polycyclic Aromatic Hydrocarbons 298-301 aryl hydrocarbon receptor Homo sapiens 142-153 33319219-1 2021 Although it is well established that human cytochrome P450 1 (CYP1) family enzymes are induced by cigarette smoking through activation of the Ah receptor (AhR), it is not known whether this leads to increased metabolic activation or detoxification of carcinogenic polycyclic aromatic hydrocarbons (PAH), which are present in cigarette smoke and the general environment. Polycyclic Aromatic Hydrocarbons 298-301 aryl hydrocarbon receptor Homo sapiens 155-158 33964743-6 2021 The PAH-CALUX assays were applied to evaluate aryl hydrocarbon receptor (AhR) ligand activities in crude extracts and different fractions from the PM samples. Polycyclic Aromatic Hydrocarbons 4-7 aryl hydrocarbon receptor Homo sapiens 46-71 33964743-9 2021 AhR-mediated activities of more polar compounds and interaction effects between PAH-related compounds were observed. Polycyclic Aromatic Hydrocarbons 80-83 aryl hydrocarbon receptor Homo sapiens 0-3 33902245-6 2021 The concentration of PAHs was positively correlated with the levels of beta2 microglobulin, total cholesterol and 24-hour urine total protein (r=0.509, 0.336, and 0.653, respectively, all P<0.05), but was negatively correlated with the levels of total protein and albumin (r=-0.499,-0.530, respectively, both P<0.05). Polycyclic Aromatic Hydrocarbons 21-25 beta-2-microglobulin Homo sapiens 71-90 33902245-7 2021 Additionally, the concentration of PAHs was negatively correlated with the level of HO-1 (r=-0.358, P=0.017). Polycyclic Aromatic Hydrocarbons 35-39 heme oxygenase 1 Homo sapiens 84-88 33902245-8 2021 Linear regression analysis showed that the concentration of HO-1 decreased by 1.737 mug/L when the concentration of PAHs increased by 1 mg/L (P=0.035). Polycyclic Aromatic Hydrocarbons 116-120 heme oxygenase 1 Homo sapiens 60-64 33984772-0 2021 Organ and tissue-specific distribution of selected polycyclic aromatic hydrocarbons (PAHs) in ApoE-KO mouse. Polycyclic Aromatic Hydrocarbons 51-83 apolipoprotein E Mus musculus 94-98 33984772-0 2021 Organ and tissue-specific distribution of selected polycyclic aromatic hydrocarbons (PAHs) in ApoE-KO mouse. Polycyclic Aromatic Hydrocarbons 85-89 apolipoprotein E Mus musculus 94-98 33742801-3 2021 The results indicate that the contents of chlorinated PAHs (Cl-PAHs) in the fly ash from the CFPPs and WIPP were 1.06-1.67 ng g-1 and 2.76 ng g-1, respectively, and the contents of brominated PAHs (Br-PAHs) in the fly ash from the CFPPs and WIPP were 26.4-44.2 ng g-1 and 6.31 ng g-1, respectively. Polycyclic Aromatic Hydrocarbons 54-58 goliath Drosophila melanogaster 126-135 30341759-0 2021 Feasibility of Sijunzi Tang (Chinese medicine) to enhance protein disulfide isomerase activities for reactivating malate dehydrogenase deactivated by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 150-182 prolyl 4-hydroxylase subunit beta Homo sapiens 58-85 30341759-0 2021 Feasibility of Sijunzi Tang (Chinese medicine) to enhance protein disulfide isomerase activities for reactivating malate dehydrogenase deactivated by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 150-182 malic enzyme 1 Homo sapiens 114-134 33359989-1 2021 Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants associated with adverse human effects including cancer, and the aryl hydrocarbon receptor (AhR) is a key ligand-activated transcription factor mediating their toxicity. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 144-169 33359989-1 2021 Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants associated with adverse human effects including cancer, and the aryl hydrocarbon receptor (AhR) is a key ligand-activated transcription factor mediating their toxicity. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 171-174 33359989-1 2021 Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants associated with adverse human effects including cancer, and the aryl hydrocarbon receptor (AhR) is a key ligand-activated transcription factor mediating their toxicity. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 144-169 33359989-1 2021 Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants associated with adverse human effects including cancer, and the aryl hydrocarbon receptor (AhR) is a key ligand-activated transcription factor mediating their toxicity. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 171-174 33559210-7 2021 PAH exposures during differentiation did not alter monocyte-derived macrophage (MDM) numbers; however, B[a]A and 6-MIX exposures significantly altered M1/M2 polarization in a CYP1A1-dependent manner. Polycyclic Aromatic Hydrocarbons 0-3 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 175-181 33513515-1 2021 Epidemiological studies show that the burden of polycyclic aromatic hydrocarbons in human body is associated with the occurrence of insulin resistance and diabetes. Polycyclic Aromatic Hydrocarbons 48-80 insulin Homo sapiens 132-139 33333309-0 2021 Identification of structural properties influencing the metabolism of polycyclic aromatic hydrocarbons by cytochrome P450 1A1. Polycyclic Aromatic Hydrocarbons 70-102 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 106-125 33333309-1 2021 Cytochrome P450 1A1 (CYP1A1) has served as a known metabolic enzyme that mediates the carcinogenesis of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 104-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 33333309-1 2021 Cytochrome P450 1A1 (CYP1A1) has served as a known metabolic enzyme that mediates the carcinogenesis of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 104-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 33333309-1 2021 Cytochrome P450 1A1 (CYP1A1) has served as a known metabolic enzyme that mediates the carcinogenesis of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 138-142 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 33333309-1 2021 Cytochrome P450 1A1 (CYP1A1) has served as a known metabolic enzyme that mediates the carcinogenesis of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 138-142 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 33333309-4 2021 van der Waals interactions (glide vdw) appeared to be important for PAH binding to CYP1A1 and were mainly affected by the molecular weight and hydrophobic structures of PAHs. Polycyclic Aromatic Hydrocarbons 68-71 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 83-89 33288249-1 2021 Polycyclic aromatic hydrocarbon exposure accelerates the initiation and progression of lung cancer through aryl hydrocarbon receptor (AHR) signaling. Polycyclic Aromatic Hydrocarbons 0-31 aryl hydrocarbon receptor Homo sapiens 107-132 33288249-1 2021 Polycyclic aromatic hydrocarbon exposure accelerates the initiation and progression of lung cancer through aryl hydrocarbon receptor (AHR) signaling. Polycyclic Aromatic Hydrocarbons 0-31 aryl hydrocarbon receptor Homo sapiens 134-137 33444019-1 2021 A key step in gas-phase polycyclic aromatic hydrocarbon (PAH) formation involves the addition of acetylene (or other alkyne) to sigma-type aromatic radicals, with successive additions yielding more complex PAHs. Polycyclic Aromatic Hydrocarbons 24-55 gastrin Homo sapiens 14-17 33444019-1 2021 A key step in gas-phase polycyclic aromatic hydrocarbon (PAH) formation involves the addition of acetylene (or other alkyne) to sigma-type aromatic radicals, with successive additions yielding more complex PAHs. Polycyclic Aromatic Hydrocarbons 57-60 gastrin Homo sapiens 14-17 33249052-11 2021 PAH mixtures modulate AHR, CAR activation and their target genes. Polycyclic Aromatic Hydrocarbons 0-3 aryl hydrocarbon receptor Homo sapiens 22-25 32634658-0 2021 IL-22: A potential mediator of associations between urinary polycyclic aromatic hydrocarbon metabolites with fasting plasma glucose and type 2 diabetes. Polycyclic Aromatic Hydrocarbons 60-91 interleukin 22 Homo sapiens 0-5 32634658-3 2021 In this study, we investigated 3031 Chinese urban adults to discover the relationship between PAH exposure and plasma Interleukin-22 (IL-22) and potential role of IL-22 in the association between PAH and fasting plasma glucose (FPG) or risk of T2D. Polycyclic Aromatic Hydrocarbons 94-97 interleukin 22 Homo sapiens 118-132 32634658-3 2021 In this study, we investigated 3031 Chinese urban adults to discover the relationship between PAH exposure and plasma Interleukin-22 (IL-22) and potential role of IL-22 in the association between PAH and fasting plasma glucose (FPG) or risk of T2D. Polycyclic Aromatic Hydrocarbons 94-97 interleukin 22 Homo sapiens 134-139 33023449-1 2021 CYP1A1 and CYP1B1 are extrahepatic P450 family members involved in the metabolism of procarcinogens, such as PAHs, heterocyclic amines and halogen-containing organic compounds. Polycyclic Aromatic Hydrocarbons 109-113 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 33023449-1 2021 CYP1A1 and CYP1B1 are extrahepatic P450 family members involved in the metabolism of procarcinogens, such as PAHs, heterocyclic amines and halogen-containing organic compounds. Polycyclic Aromatic Hydrocarbons 109-113 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 11-17 33137431-9 2021 In addition, sixteen alkaloids, sixty-one phenolics and eight polycyclic aromatic hydrocarbons have been isolated or identified from active extracts or fractions that are exhibiting PDE5 inhibitory activity. Polycyclic Aromatic Hydrocarbons 62-94 phosphodiesterase 5A Homo sapiens 182-186 33249052-11 2021 PAH mixtures modulate AHR, CAR activation and their target genes. Polycyclic Aromatic Hydrocarbons 0-3 nuclear receptor subfamily 1 group I member 3 Homo sapiens 27-30 33129239-8 2021 Conclusion: We found a significant association of OGG1 heterozygous (wt/mt) and homozygous (mt/mt) variants with oxidative and genotoxic damage, suggesting that these polymorphisms may modulate the effects of polycyclic aromatic hydrocarbons exposure in occupational workers. Polycyclic Aromatic Hydrocarbons 209-241 8-oxoguanine DNA glycosylase Homo sapiens 50-54 33494198-4 2021 In this work, the exploitation of municipal wastes for PHA production is evaluated from the environmental and health safety aspect by determining the presence of polycyclic aromatic hydrocarbons (PAHs) in both commercial and waste-based PHA samples. Polycyclic Aromatic Hydrocarbons 162-194 lamin B receptor Homo sapiens 55-58 33494198-4 2021 In this work, the exploitation of municipal wastes for PHA production is evaluated from the environmental and health safety aspect by determining the presence of polycyclic aromatic hydrocarbons (PAHs) in both commercial and waste-based PHA samples. Polycyclic Aromatic Hydrocarbons 162-194 lamin B receptor Homo sapiens 237-240 33494198-4 2021 In this work, the exploitation of municipal wastes for PHA production is evaluated from the environmental and health safety aspect by determining the presence of polycyclic aromatic hydrocarbons (PAHs) in both commercial and waste-based PHA samples. Polycyclic Aromatic Hydrocarbons 196-200 lamin B receptor Homo sapiens 55-58 33494198-4 2021 In this work, the exploitation of municipal wastes for PHA production is evaluated from the environmental and health safety aspect by determining the presence of polycyclic aromatic hydrocarbons (PAHs) in both commercial and waste-based PHA samples. Polycyclic Aromatic Hydrocarbons 196-200 lamin B receptor Homo sapiens 237-240 33494198-7 2021 Commercial PHA derived from crops, selected for comparison, showed PAH content comparable to that detected in PHAs derived from organic fraction of municipal solid waste. Polycyclic Aromatic Hydrocarbons 67-70 lamin B receptor Homo sapiens 11-14 32747956-0 2020 A polycyclic aromatic hydrocarbon-enriched environmental chemical mixture enhances AhR, antiapoptotic signaling and a proliferative phenotype in breast cancer cells. Polycyclic Aromatic Hydrocarbons 2-33 aryl hydrocarbon receptor Homo sapiens 83-86 33408298-0 2021 Polycyclic aromatic hydrocarbons induce CYP3A5 gene expression via aryl hydrocarbon receptor in HepG2 cells. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 40-46 33408298-0 2021 Polycyclic aromatic hydrocarbons induce CYP3A5 gene expression via aryl hydrocarbon receptor in HepG2 cells. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 67-92 33408298-5 2021 CYP3A5 mRNA expression was induced by the polycyclic aromatic hydrocarbons (PAHs) such as 3-methylcholanthrene (3MC) and benzo[a]pyrene in HepG2 cells. Polycyclic Aromatic Hydrocarbons 42-74 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 0-6 33408298-5 2021 CYP3A5 mRNA expression was induced by the polycyclic aromatic hydrocarbons (PAHs) such as 3-methylcholanthrene (3MC) and benzo[a]pyrene in HepG2 cells. Polycyclic Aromatic Hydrocarbons 76-80 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 0-6 33408298-6 2021 To determine whether the PAHs induced CYP3A5 gene expression via AhR, we generated AhR knockout (AhR KO) HepG2 cells. Polycyclic Aromatic Hydrocarbons 25-29 cytochrome P450 family 3 subfamily A member 5 Homo sapiens 38-44 33408298-6 2021 To determine whether the PAHs induced CYP3A5 gene expression via AhR, we generated AhR knockout (AhR KO) HepG2 cells. Polycyclic Aromatic Hydrocarbons 25-29 aryl hydrocarbon receptor Homo sapiens 65-68 33256967-0 2021 Polycyclic aromatic hydrocarbon status in post-hurricane Harvey sediments: Considerations for environmental sampling in the Galveston Bay/Houston Ship Channel region. Polycyclic Aromatic Hydrocarbons 0-31 inositol polyphosphate-5-phosphatase D Homo sapiens 146-150 32747956-7 2020 Furthermore, the PAH mixture caused significant growth increases in ER-negative breast cancer cell derived 3D tumor organoids, providing further evidence for the role of a natural-derived PAH mixture in enhancing a tumor proliferative phenotype. Polycyclic Aromatic Hydrocarbons 188-191 estrogen receptor 1 Homo sapiens 68-70 33396476-0 2020 Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 46-71 33396476-0 2020 Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells. Polycyclic Aromatic Hydrocarbons 0-32 nuclear receptor subfamily 1 group I member 3 Homo sapiens 80-112 32747956-5 2020 We demonstrate that low-dose PAH mixture (6, 30 and 300 nM) increased aryl hydrocarbon receptor (AhR) expression and CYP activity in estrogen receptor (ER) positive but not normal mammary or ER-negative breast cancer cells, and that upregulated AhR signaling corresponded with increased cell proliferation and expression of antiapoptotic and antioxidant proteins XIAP and SOD1. Polycyclic Aromatic Hydrocarbons 29-32 aryl hydrocarbon receptor Homo sapiens 70-95 32747956-5 2020 We demonstrate that low-dose PAH mixture (6, 30 and 300 nM) increased aryl hydrocarbon receptor (AhR) expression and CYP activity in estrogen receptor (ER) positive but not normal mammary or ER-negative breast cancer cells, and that upregulated AhR signaling corresponded with increased cell proliferation and expression of antiapoptotic and antioxidant proteins XIAP and SOD1. Polycyclic Aromatic Hydrocarbons 29-32 aryl hydrocarbon receptor Homo sapiens 97-100 32747956-5 2020 We demonstrate that low-dose PAH mixture (6, 30 and 300 nM) increased aryl hydrocarbon receptor (AhR) expression and CYP activity in estrogen receptor (ER) positive but not normal mammary or ER-negative breast cancer cells, and that upregulated AhR signaling corresponded with increased cell proliferation and expression of antiapoptotic and antioxidant proteins XIAP and SOD1. Polycyclic Aromatic Hydrocarbons 29-32 estrogen receptor 1 Homo sapiens 133-150 32747956-5 2020 We demonstrate that low-dose PAH mixture (6, 30 and 300 nM) increased aryl hydrocarbon receptor (AhR) expression and CYP activity in estrogen receptor (ER) positive but not normal mammary or ER-negative breast cancer cells, and that upregulated AhR signaling corresponded with increased cell proliferation and expression of antiapoptotic and antioxidant proteins XIAP and SOD1. Polycyclic Aromatic Hydrocarbons 29-32 estrogen receptor 1 Homo sapiens 152-154 32747956-5 2020 We demonstrate that low-dose PAH mixture (6, 30 and 300 nM) increased aryl hydrocarbon receptor (AhR) expression and CYP activity in estrogen receptor (ER) positive but not normal mammary or ER-negative breast cancer cells, and that upregulated AhR signaling corresponded with increased cell proliferation and expression of antiapoptotic and antioxidant proteins XIAP and SOD1. Polycyclic Aromatic Hydrocarbons 29-32 aryl hydrocarbon receptor Homo sapiens 245-248 32747956-5 2020 We demonstrate that low-dose PAH mixture (6, 30 and 300 nM) increased aryl hydrocarbon receptor (AhR) expression and CYP activity in estrogen receptor (ER) positive but not normal mammary or ER-negative breast cancer cells, and that upregulated AhR signaling corresponded with increased cell proliferation and expression of antiapoptotic and antioxidant proteins XIAP and SOD1. Polycyclic Aromatic Hydrocarbons 29-32 X-linked inhibitor of apoptosis Homo sapiens 363-367 32747956-5 2020 We demonstrate that low-dose PAH mixture (6, 30 and 300 nM) increased aryl hydrocarbon receptor (AhR) expression and CYP activity in estrogen receptor (ER) positive but not normal mammary or ER-negative breast cancer cells, and that upregulated AhR signaling corresponded with increased cell proliferation and expression of antiapoptotic and antioxidant proteins XIAP and SOD1. Polycyclic Aromatic Hydrocarbons 29-32 superoxide dismutase 1 Homo sapiens 372-376 32747956-6 2020 We employed a mathematical model to validate PAH-mediated increases in AhR and XIAP expression in the MCF-7 ER-positive cell line. Polycyclic Aromatic Hydrocarbons 45-48 aryl hydrocarbon receptor Homo sapiens 71-74 32747956-6 2020 We employed a mathematical model to validate PAH-mediated increases in AhR and XIAP expression in the MCF-7 ER-positive cell line. Polycyclic Aromatic Hydrocarbons 45-48 X-linked inhibitor of apoptosis Homo sapiens 79-83 32747956-6 2020 We employed a mathematical model to validate PAH-mediated increases in AhR and XIAP expression in the MCF-7 ER-positive cell line. Polycyclic Aromatic Hydrocarbons 45-48 estrogen receptor 1 Homo sapiens 108-110 32747956-7 2020 Furthermore, the PAH mixture caused significant growth increases in ER-negative breast cancer cell derived 3D tumor organoids, providing further evidence for the role of a natural-derived PAH mixture in enhancing a tumor proliferative phenotype. Polycyclic Aromatic Hydrocarbons 17-20 estrogen receptor 1 Homo sapiens 68-70 32829279-0 2020 Polycyclic aromatic hydrocarbon exposure results in altered CRH, reproductive, and thyroid hormone concentrations during human pregnancy. Polycyclic Aromatic Hydrocarbons 0-31 corticotropin releasing hormone Homo sapiens 60-63 33274957-6 2020 Expression levels of aryl hydrocarbon receptor, which mediates the effect of polycyclic aromatic hydrocarbons, and cytokines in peripheral blood nuclear cells (PBMCs) were measured using reverse transcription polymerase chain reaction. Polycyclic Aromatic Hydrocarbons 77-109 aryl hydrocarbon receptor Homo sapiens 21-46 32979814-0 2020 PAH exposure is associated with enhanced risk for pediatric dyslipidemia through serum SOD reduction. Polycyclic Aromatic Hydrocarbons 0-3 superoxide dismutase 1 Homo sapiens 87-90 33213213-2 2020 The toxicity of PAHs, which include benzo(alpha)pyrene (BP), is mediated by the activation of R450 cytochromes of the 1A subfamily (CYP1A1 and CYP1A2). Polycyclic Aromatic Hydrocarbons 16-20 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 132-138 33213213-2 2020 The toxicity of PAHs, which include benzo(alpha)pyrene (BP), is mediated by the activation of R450 cytochromes of the 1A subfamily (CYP1A1 and CYP1A2). Polycyclic Aromatic Hydrocarbons 16-20 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 143-149 32512434-6 2020 Evaluation of KSS data for the 4 h extractions showed that soil type and selected HMW-PAH properties (literature based molecular weight and octanol-carbon partition coefficients) affect the amount of HMW-PAH released from soil into sebum. Polycyclic Aromatic Hydrocarbons 204-207 cilia and flagella associated protein 97 Homo sapiens 82-85 33304900-0 2020 Neural Tube Defects and ZIC4 Hypomethylation in Relation to Polycyclic Aromatic Hydrocarbon Exposure. Polycyclic Aromatic Hydrocarbons 60-91 zinc finger protein of the cerebellum 4 Mus musculus 24-28 33304900-12 2020 Conclusion: Hypomethylation of the ZIC4 promoter region and 5" UTR may increase the risk for NTDs; oxidative stress is likely to play a role in the methylation change of Zic4 in response to PAH exposure in NTD formation. Polycyclic Aromatic Hydrocarbons 190-193 zinc finger protein of the cerebellum 4 Mus musculus 35-39 33304900-12 2020 Conclusion: Hypomethylation of the ZIC4 promoter region and 5" UTR may increase the risk for NTDs; oxidative stress is likely to play a role in the methylation change of Zic4 in response to PAH exposure in NTD formation. Polycyclic Aromatic Hydrocarbons 190-193 zinc finger protein of the cerebellum 4 Mus musculus 170-174 32679438-0 2020 Environmental six-ring polycyclic aromatic hydrocarbons are potent inducers of the AhR-dependent signaling in human cells. Polycyclic Aromatic Hydrocarbons 23-55 aryl hydrocarbon receptor Homo sapiens 83-86 32993298-0 2020 Altered metabolism of polycyclic aromatic hydrocarbons by UDP-glycosyltransferase 3A2 (UGT3A2) missense variants. Polycyclic Aromatic Hydrocarbons 22-54 UDP glycosyltransferase family 3 member A2 Homo sapiens 58-85 32993298-0 2020 Altered metabolism of polycyclic aromatic hydrocarbons by UDP-glycosyltransferase 3A2 (UGT3A2) missense variants. Polycyclic Aromatic Hydrocarbons 22-54 UDP glycosyltransferase family 3 member A2 Homo sapiens 87-93 32993298-4 2020 The goal of the present study was to assess the functional effects of UGT3A2 missense variants (MAF >= 0.005) on PAH metabolism and the utilization of cosubstrates. Polycyclic Aromatic Hydrocarbons 113-116 UDP glycosyltransferase family 3 member A2 Homo sapiens 70-76 32512434-0 2020 Soil-sebum partition coefficients for high molecular weight polycyclic aromatic hydrocarbons (HMW-PAH). Polycyclic Aromatic Hydrocarbons 60-92 cilia and flagella associated protein 97 Homo sapiens 94-97 32512434-6 2020 Evaluation of KSS data for the 4 h extractions showed that soil type and selected HMW-PAH properties (literature based molecular weight and octanol-carbon partition coefficients) affect the amount of HMW-PAH released from soil into sebum. Polycyclic Aromatic Hydrocarbons 86-89 cilia and flagella associated protein 97 Homo sapiens 82-85 32512434-6 2020 Evaluation of KSS data for the 4 h extractions showed that soil type and selected HMW-PAH properties (literature based molecular weight and octanol-carbon partition coefficients) affect the amount of HMW-PAH released from soil into sebum. Polycyclic Aromatic Hydrocarbons 86-89 cilia and flagella associated protein 97 Homo sapiens 200-203 32512434-6 2020 Evaluation of KSS data for the 4 h extractions showed that soil type and selected HMW-PAH properties (literature based molecular weight and octanol-carbon partition coefficients) affect the amount of HMW-PAH released from soil into sebum. Polycyclic Aromatic Hydrocarbons 204-207 cilia and flagella associated protein 97 Homo sapiens 200-203 32428741-5 2020 The resulting data suggested that hydrophobic factors (Kow, Koc and Sw) affected PAH treatability more than the reactivity of PAH (electron affinity and ionization potential). Polycyclic Aromatic Hydrocarbons 81-84 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 60-63 32960593-6 2020 The mixture effects were not only dominated by legacy pollutants (e.g., polycyclic aromatic hydrocarbon (PAHs) in the bioassay for activation of the aryl-hydrocarbon receptor (AhR) and oxidative stress response (AREc32)), but also by present-use chemicals (e.g., plastic additives for binding to the peroxisome proliferator-activated receptor gamma (PPARgamma)), with different fingerprints between whole sediments and bioavailable extracts. Polycyclic Aromatic Hydrocarbons 72-103 aryl hydrocarbon receptor Homo sapiens 149-174 32960593-6 2020 The mixture effects were not only dominated by legacy pollutants (e.g., polycyclic aromatic hydrocarbon (PAHs) in the bioassay for activation of the aryl-hydrocarbon receptor (AhR) and oxidative stress response (AREc32)), but also by present-use chemicals (e.g., plastic additives for binding to the peroxisome proliferator-activated receptor gamma (PPARgamma)), with different fingerprints between whole sediments and bioavailable extracts. Polycyclic Aromatic Hydrocarbons 72-103 aryl hydrocarbon receptor Homo sapiens 176-179 32960593-6 2020 The mixture effects were not only dominated by legacy pollutants (e.g., polycyclic aromatic hydrocarbon (PAHs) in the bioassay for activation of the aryl-hydrocarbon receptor (AhR) and oxidative stress response (AREc32)), but also by present-use chemicals (e.g., plastic additives for binding to the peroxisome proliferator-activated receptor gamma (PPARgamma)), with different fingerprints between whole sediments and bioavailable extracts. Polycyclic Aromatic Hydrocarbons 105-109 aryl hydrocarbon receptor Homo sapiens 149-174 32960593-6 2020 The mixture effects were not only dominated by legacy pollutants (e.g., polycyclic aromatic hydrocarbon (PAHs) in the bioassay for activation of the aryl-hydrocarbon receptor (AhR) and oxidative stress response (AREc32)), but also by present-use chemicals (e.g., plastic additives for binding to the peroxisome proliferator-activated receptor gamma (PPARgamma)), with different fingerprints between whole sediments and bioavailable extracts. Polycyclic Aromatic Hydrocarbons 105-109 aryl hydrocarbon receptor Homo sapiens 176-179 32684523-1 2020 Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one of the main ingredients in cigarettes and an agonist of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 23-55 prohibitin 2 Mus musculus 15-18 32684523-1 2020 Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one of the main ingredients in cigarettes and an agonist of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 23-55 aryl-hydrocarbon receptor Mus musculus 158-183 32684523-1 2020 Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one of the main ingredients in cigarettes and an agonist of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 23-55 aryl-hydrocarbon receptor Mus musculus 185-188 32684523-1 2020 Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one of the main ingredients in cigarettes and an agonist of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 57-60 prohibitin 2 Mus musculus 15-18 32684523-1 2020 Benzo[a]pyrene(BaP), a polycyclic aromatic hydrocarbons (PAH) of environmental pollutants, is one of the main ingredients in cigarettes and an agonist of the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 57-60 aryl-hydrocarbon receptor Mus musculus 158-183 33046999-3 2021 In this study, mass concentrations of the PM1 particle fraction (particulate matter with an equivalent aerodynamic diameter < 1 mum) and polycyclic aromatic hydrocarbons (PAHs) in PM1 and NO2 were measured and compared with concentrations measured in the same period the year before. Polycyclic Aromatic Hydrocarbons 137-169 transmembrane protein 11 Homo sapiens 180-183 33046999-3 2021 In this study, mass concentrations of the PM1 particle fraction (particulate matter with an equivalent aerodynamic diameter < 1 mum) and polycyclic aromatic hydrocarbons (PAHs) in PM1 and NO2 were measured and compared with concentrations measured in the same period the year before. Polycyclic Aromatic Hydrocarbons 171-175 transmembrane protein 11 Homo sapiens 180-183 32615350-10 2020 Altogether, these data support that similar to interactions between PAHs, mixtures of PAHs and oxy-PAHs may cause increased developmental and cardiovascular toxicity in ZFEs through an AhR-dependent mechanism. Polycyclic Aromatic Hydrocarbons 68-72 aryl hydrocarbon receptor 1a Danio rerio 185-188 32800255-2 2020 Limited evidence focuses on the influence of occupational exposure to polycyclic aromatic hydrocarbon (PAH) and metal fumes on AGE and RAGE in shipyard welders. Polycyclic Aromatic Hydrocarbons 70-101 advanced glycosylation end-product specific receptor Homo sapiens 135-139 32800255-2 2020 Limited evidence focuses on the influence of occupational exposure to polycyclic aromatic hydrocarbon (PAH) and metal fumes on AGE and RAGE in shipyard welders. Polycyclic Aromatic Hydrocarbons 103-106 advanced glycosylation end-product specific receptor Homo sapiens 135-139 32615350-10 2020 Altogether, these data support that similar to interactions between PAHs, mixtures of PAHs and oxy-PAHs may cause increased developmental and cardiovascular toxicity in ZFEs through an AhR-dependent mechanism. Polycyclic Aromatic Hydrocarbons 86-90 aryl hydrocarbon receptor 1a Danio rerio 185-188 32730838-13 2020 SIGNIFICANCE: These results partially indicated that VPA may augment the PAH-mediated induction of CYP1B1 and CYP1A1 through the activation of transcription by HDAC inhibition. Polycyclic Aromatic Hydrocarbons 73-76 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 99-105 32730838-13 2020 SIGNIFICANCE: These results partially indicated that VPA may augment the PAH-mediated induction of CYP1B1 and CYP1A1 through the activation of transcription by HDAC inhibition. Polycyclic Aromatic Hydrocarbons 73-76 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 110-116 32739632-4 2020 The ERL/ERM, TEL/PEL and TEC/PEC values showed that the potential toxicity of PAHs was at low to medium level, but the presence of benzo[a]pyrene (BaP) and benzo[e]pyrene (BeP) requires more attention and research. Polycyclic Aromatic Hydrocarbons 78-82 ETS variant transcription factor 6 Homo sapiens 13-16 32739632-4 2020 The ERL/ERM, TEL/PEL and TEC/PEC values showed that the potential toxicity of PAHs was at low to medium level, but the presence of benzo[a]pyrene (BaP) and benzo[e]pyrene (BeP) requires more attention and research. Polycyclic Aromatic Hydrocarbons 78-82 tec protein tyrosine kinase Homo sapiens 25-28 32892922-5 2020 The immobilized microbial consortium had a high HMW-PAH removal ability and good floatability and magnetic properties and could be collected by an external magnetic field. Polycyclic Aromatic Hydrocarbons 52-55 cilia and flagella associated protein 97 Homo sapiens 48-51 32783831-1 2020 BACKGROUND: Although some studies have suggested that exposure to polycyclic aromatic hydrocarbons (PAHs) induces neurodevelopmental disturbances in children and neurodegeneration in animals, the neurotoxic effect of PAH exposure is unclear in adults. Polycyclic Aromatic Hydrocarbons 66-98 phenylalanine hydroxylase Homo sapiens 100-103 32992293-11 2020 This work indicates that human endometrial cells can metabolize PAHs into estrogenic metabolites, which may induce cell proliferation through non-ER-regulated pathways. Polycyclic Aromatic Hydrocarbons 64-68 estrogen receptor 1 Homo sapiens 146-148 32877761-4 2020 The PAH-induced carcinogenesis is shown to be mediated through the activation of a cytosolic receptor, aryl hydrocarbon receptor (AhR)/Cytochrome P4501A pathway, suggesting a possible direct link between AhR and CSCs. Polycyclic Aromatic Hydrocarbons 4-7 aryl hydrocarbon receptor Homo sapiens 103-128 32726451-0 2020 Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2. Polycyclic Aromatic Hydrocarbons 0-31 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 74-99 32726451-0 2020 Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2. Polycyclic Aromatic Hydrocarbons 0-31 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 129-135 32726451-0 2020 Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2. Polycyclic Aromatic Hydrocarbons 0-31 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 140-146 32726451-0 2020 Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2. Polycyclic Aromatic Hydrocarbons 33-36 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 74-99 32726451-0 2020 Polycyclic Aromatic Hydrocarbon (PAH)-Induced Pulmonary Carcinogenesis in Cytochrome P450 (CYP) 1A1- and 1A2-null Mice: Roles of CYP1A1 and CYP1A2. Polycyclic Aromatic Hydrocarbons 33-36 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 140-146 32726451-6 2020 In this investigation, we tested the hypothesis that mice lacking the genes for Cyp1a1 or Cyp1a2 will display altered susceptibilities to PAH-induced pulmonary carcinogenesis. Polycyclic Aromatic Hydrocarbons 138-141 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 80-86 32726451-6 2020 In this investigation, we tested the hypothesis that mice lacking the genes for Cyp1a1 or Cyp1a2 will display altered susceptibilities to PAH-induced pulmonary carcinogenesis. Polycyclic Aromatic Hydrocarbons 138-141 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 90-96 32726451-9 2020 Cyp1a1-/- and Cyp1a2-/- mice treated with PAHs displayed a compensatory pattern, where knocking out one Cyp1a gene led to increased expression of the other. Polycyclic Aromatic Hydrocarbons 42-46 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 0-6 32726451-9 2020 Cyp1a1-/- and Cyp1a2-/- mice treated with PAHs displayed a compensatory pattern, where knocking out one Cyp1a gene led to increased expression of the other. Polycyclic Aromatic Hydrocarbons 42-46 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 14-20 32726451-12 2020 In conclusion, Cyp1a1-/- mice were less susceptible to PAH-induced pulmonary carcinogenesis, while Cyp1a2-/- mice were more susceptible. Polycyclic Aromatic Hydrocarbons 55-58 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 15-21 33178426-0 2020 Association between H3K36me3 modification and methylation of LINE-1 and MGMT in peripheral blood lymphocytes of PAH-exposed workers. Polycyclic Aromatic Hydrocarbons 112-115 O-6-methylguanine-DNA methyltransferase Homo sapiens 72-76 33178426-2 2020 The PAH-exposed group showed higher internal PAH exposure level, enhanced DNA damage and increased MGMT expression (all P < 0.001). Polycyclic Aromatic Hydrocarbons 4-7 O-6-methylguanine-DNA methyltransferase Homo sapiens 99-103 33178426-3 2020 Notably, the methylation of LINE-1 and MGMT decreased by 3.9 and 40.8%, respectively, while H3K36me3 level was 1.7 times higher in PBLCs of PAH-exposed group compared to control group (all P < 0.001). Polycyclic Aromatic Hydrocarbons 140-143 O-6-methylguanine-DNA methyltransferase Homo sapiens 39-43 33178426-7 2020 The in vitro study using human bronchial epithelial cells treated with the organic extract of coke oven emissions confirmed that H3K36me3 is important for MGMT expression following PAH exposure. Polycyclic Aromatic Hydrocarbons 181-184 O-6-methylguanine-DNA methyltransferase Homo sapiens 155-159 33178426-8 2020 In summary, our study indicates that histone modification and DNA methylation might have synergistic effects on DNA damage induced by PAH exposure at the whole genome level and H3K36me3 is more essential for MGMT expression during the course. Polycyclic Aromatic Hydrocarbons 134-137 O-6-methylguanine-DNA methyltransferase Homo sapiens 208-212 32416390-14 2020 The lowest COX-2 and PGE2 upregulation was observed for naphthalene (2-ring PAH). Polycyclic Aromatic Hydrocarbons 76-79 cytochrome c oxidase II, mitochondrial Mus musculus 11-16 32375090-4 2020 Results showed that concentrations of individual PAHs in the surface water ranged from less than the limit of quantification (LOQ) to 949 ng L-1, indicating a reduction of PAH contamination level after the implementation of environmental management actions. Polycyclic Aromatic Hydrocarbons 49-52 L1 cell adhesion molecule Homo sapiens 141-144 32375090-5 2020 Influent of MWWTPs and wastewater from industrial enterprises exhibited relatively high PAHs concentrations (mean: 880 ng L-1 and 642 ng L-1, respectively); these samples also exhibited a similar seasonal variation as well as composition of PAH congeners to those found in surface water, and therefore were designated as the main emission sources of PAHs in the studied region. Polycyclic Aromatic Hydrocarbons 89-92 L1 cell adhesion molecule Homo sapiens 123-126 32375090-5 2020 Influent of MWWTPs and wastewater from industrial enterprises exhibited relatively high PAHs concentrations (mean: 880 ng L-1 and 642 ng L-1, respectively); these samples also exhibited a similar seasonal variation as well as composition of PAH congeners to those found in surface water, and therefore were designated as the main emission sources of PAHs in the studied region. Polycyclic Aromatic Hydrocarbons 89-93 L1 cell adhesion molecule Homo sapiens 123-126 32375090-5 2020 Influent of MWWTPs and wastewater from industrial enterprises exhibited relatively high PAHs concentrations (mean: 880 ng L-1 and 642 ng L-1, respectively); these samples also exhibited a similar seasonal variation as well as composition of PAH congeners to those found in surface water, and therefore were designated as the main emission sources of PAHs in the studied region. Polycyclic Aromatic Hydrocarbons 89-93 L1 cell adhesion molecule Homo sapiens 138-141 32375093-12 2020 For AhR-mediated activity, chemical analyses explained on average 44% of the effect and the main identified effect-drivers were polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 128-160 aryl hydrocarbon receptor Homo sapiens 4-7 32488710-3 2020 Genetic polymorphisms in genes encoding PAH-metabolizing enzymes like glutathione S-transferases (GSTM1, GSTP1, GSTT1) which conjugate glutathione to PAHs for reduction of oxidative stress may affect an individual"s response to PAH exposure. Polycyclic Aromatic Hydrocarbons 40-43 glutathione S-transferase mu 1 Homo sapiens 98-103 32488710-3 2020 Genetic polymorphisms in genes encoding PAH-metabolizing enzymes like glutathione S-transferases (GSTM1, GSTP1, GSTT1) which conjugate glutathione to PAHs for reduction of oxidative stress may affect an individual"s response to PAH exposure. Polycyclic Aromatic Hydrocarbons 40-43 glutathione S-transferase pi 1 Homo sapiens 105-110 32488710-3 2020 Genetic polymorphisms in genes encoding PAH-metabolizing enzymes like glutathione S-transferases (GSTM1, GSTP1, GSTT1) which conjugate glutathione to PAHs for reduction of oxidative stress may affect an individual"s response to PAH exposure. Polycyclic Aromatic Hydrocarbons 40-43 glutathione S-transferase theta 1 Homo sapiens 112-117 32488710-3 2020 Genetic polymorphisms in genes encoding PAH-metabolizing enzymes like glutathione S-transferases (GSTM1, GSTP1, GSTT1) which conjugate glutathione to PAHs for reduction of oxidative stress may affect an individual"s response to PAH exposure. Polycyclic Aromatic Hydrocarbons 150-153 glutathione S-transferase mu 1 Homo sapiens 98-103 32488710-3 2020 Genetic polymorphisms in genes encoding PAH-metabolizing enzymes like glutathione S-transferases (GSTM1, GSTP1, GSTT1) which conjugate glutathione to PAHs for reduction of oxidative stress may affect an individual"s response to PAH exposure. Polycyclic Aromatic Hydrocarbons 150-153 glutathione S-transferase pi 1 Homo sapiens 105-110 32488710-3 2020 Genetic polymorphisms in genes encoding PAH-metabolizing enzymes like glutathione S-transferases (GSTM1, GSTP1, GSTT1) which conjugate glutathione to PAHs for reduction of oxidative stress may affect an individual"s response to PAH exposure. Polycyclic Aromatic Hydrocarbons 150-153 glutathione S-transferase theta 1 Homo sapiens 112-117 32662596-8 2020 It was successfully applied to detect trace polycyclic aromatic hydrocarbons in some real water samples, including tap water, snow water and domestic sewage. Polycyclic Aromatic Hydrocarbons 44-76 nuclear RNA export factor 1 Homo sapiens 115-118 32687683-0 2020 An Ag2 S@ZnS coated fiber for efficient, long-life solid-phase microextraction of polycyclic aromatic hydrocarbons in water. Polycyclic Aromatic Hydrocarbons 82-114 angiotensin II receptor type 1 Homo sapiens 3-8 32687683-2 2020 Herein, an inorganic nanocomposite material Ag2 S@ZnS was prepared and used as a coating for fibers to detect polycyclic aromatic hydrocarbons in water samples in combination with a GC with flame ionization detector. Polycyclic Aromatic Hydrocarbons 110-142 anterior gradient 2, protein disulphide isomerase family member Homo sapiens 44-47 32730838-0 2020 Expression profile of cytochrome P450s and effects of polycyclic aromatic hydrocarbons and antiepileptic drugs on CYP1 expression in MOG-G-CCM cells. Polycyclic Aromatic Hydrocarbons 54-86 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 114-118 32877761-4 2020 The PAH-induced carcinogenesis is shown to be mediated through the activation of a cytosolic receptor, aryl hydrocarbon receptor (AhR)/Cytochrome P4501A pathway, suggesting a possible direct link between AhR and CSCs. Polycyclic Aromatic Hydrocarbons 4-7 aryl hydrocarbon receptor Homo sapiens 130-133 32877761-4 2020 The PAH-induced carcinogenesis is shown to be mediated through the activation of a cytosolic receptor, aryl hydrocarbon receptor (AhR)/Cytochrome P4501A pathway, suggesting a possible direct link between AhR and CSCs. Polycyclic Aromatic Hydrocarbons 4-7 aryl hydrocarbon receptor Homo sapiens 204-207 32506686-6 2020 The method was successfully applied to determine trace polycyclic aromatic hydrocarbons in some real water samples including two kinds of bottled water, tap water and river water, a few PAHs were detected but none quantified in these samples. Polycyclic Aromatic Hydrocarbons 55-87 nuclear RNA export factor 1 Homo sapiens 153-156 32730838-1 2020 AIMS: This study was performed to investigate the expression profile of cytochrome P450 (CYP) isoforms and effects of polycyclic aromatic hydrocarbons (PAHs) and antiepileptic drugs on CYP1 expression in human astrocytoma MOG-G-CCM cells. Polycyclic Aromatic Hydrocarbons 118-150 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 185-189 32730838-1 2020 AIMS: This study was performed to investigate the expression profile of cytochrome P450 (CYP) isoforms and effects of polycyclic aromatic hydrocarbons (PAHs) and antiepileptic drugs on CYP1 expression in human astrocytoma MOG-G-CCM cells. Polycyclic Aromatic Hydrocarbons 152-156 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 185-189 32434106-6 2020 PAH exposure was associated with lower systolic pressure, pulse pressure, SOD (adjusted beta = -0.091, -0.104 and -0.154, respectively, all P < 0.05, in all children), GPx (adjusted beta 7LMW-OH-PAHs-T3 = -0.332, only in Haojiang children) and vitamin E (adjusted OR 7LMW-OH-PAHs = 0.838, 95% CI: 0.706, 0.995, only in Guiyu children). Polycyclic Aromatic Hydrocarbons 0-3 superoxide dismutase 1 Homo sapiens 74-77 32553695-2 2020 Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants that are metabolized to carcinogenic dihydrodiol epoxides (PAHDE) by cytochrome P450 1B1 (CYP1B1). Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 135-154 32553695-2 2020 Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants that are metabolized to carcinogenic dihydrodiol epoxides (PAHDE) by cytochrome P450 1B1 (CYP1B1). Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 156-162 32553695-2 2020 Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants that are metabolized to carcinogenic dihydrodiol epoxides (PAHDE) by cytochrome P450 1B1 (CYP1B1). Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 135-154 32553695-2 2020 Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants that are metabolized to carcinogenic dihydrodiol epoxides (PAHDE) by cytochrome P450 1B1 (CYP1B1). Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 156-162 32553695-11 2020 PAH effects on BMS2 cells model Lepr+MSC niche activity. Polycyclic Aromatic Hydrocarbons 0-3 leptin receptor Mus musculus 32-36 32774379-0 2020 A Versatile SERS Sensor for Multiple Determinations of Polycyclic Aromatic Hydrocarbons and Its Application Potential in Analysis of Fried Foods. Polycyclic Aromatic Hydrocarbons 55-87 seryl-tRNA synthetase 1 Homo sapiens 12-16 32774379-1 2020 Polycyclic aromatic hydrocarbons (PAHs), due to their high hydrophobicity, have low affinity for metallic SERS-active surfaces, which leads to their low SERS detection sensitivity. Polycyclic Aromatic Hydrocarbons 0-32 seryl-tRNA synthetase 1 Homo sapiens 106-110 32774379-1 2020 Polycyclic aromatic hydrocarbons (PAHs), due to their high hydrophobicity, have low affinity for metallic SERS-active surfaces, which leads to their low SERS detection sensitivity. Polycyclic Aromatic Hydrocarbons 0-32 seryl-tRNA synthetase 1 Homo sapiens 153-157 32774379-1 2020 Polycyclic aromatic hydrocarbons (PAHs), due to their high hydrophobicity, have low affinity for metallic SERS-active surfaces, which leads to their low SERS detection sensitivity. Polycyclic Aromatic Hydrocarbons 34-38 seryl-tRNA synthetase 1 Homo sapiens 106-110 32774379-1 2020 Polycyclic aromatic hydrocarbons (PAHs), due to their high hydrophobicity, have low affinity for metallic SERS-active surfaces, which leads to their low SERS detection sensitivity. Polycyclic Aromatic Hydrocarbons 34-38 seryl-tRNA synthetase 1 Homo sapiens 153-157 32774379-4 2020 In this study, a SERS sensor composed of Au nanoparticles (AuNPs) and reoxidized graphene oxide (rGO) was developed for the simultaneous determination of 16 EPA priority PAHs. Polycyclic Aromatic Hydrocarbons 170-174 seryl-tRNA synthetase 1 Homo sapiens 17-21 32464779-4 2020 Urinary metabolites of PAHs (i.e., OH-PAHs), measured as indicators of total PAH exposure, showed significant associations with markers of respiratory and systemic inflammation, including exhaled nitric oxide, interleukin (IL)-6 in exhaled breath condensate, and blood IL-2 and IL-8 levels and leucocyte count. Polycyclic Aromatic Hydrocarbons 23-26 interleukin 6 Homo sapiens 210-228 32464779-4 2020 Urinary metabolites of PAHs (i.e., OH-PAHs), measured as indicators of total PAH exposure, showed significant associations with markers of respiratory and systemic inflammation, including exhaled nitric oxide, interleukin (IL)-6 in exhaled breath condensate, and blood IL-2 and IL-8 levels and leucocyte count. Polycyclic Aromatic Hydrocarbons 23-26 interleukin 2 Homo sapiens 269-273 32464779-4 2020 Urinary metabolites of PAHs (i.e., OH-PAHs), measured as indicators of total PAH exposure, showed significant associations with markers of respiratory and systemic inflammation, including exhaled nitric oxide, interleukin (IL)-6 in exhaled breath condensate, and blood IL-2 and IL-8 levels and leucocyte count. Polycyclic Aromatic Hydrocarbons 23-26 C-X-C motif chemokine ligand 8 Homo sapiens 278-282 32418891-0 2020 "Real life" polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines. Polycyclic Aromatic Hydrocarbons 12-43 galectin 1 Homo sapiens 73-76 32736658-1 2020 BACKGROUND: Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. Polycyclic Aromatic Hydrocarbons 12-43 aryl hydrocarbon receptor Homo sapiens 104-129 32736658-1 2020 BACKGROUND: Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. Polycyclic Aromatic Hydrocarbons 12-43 aryl hydrocarbon receptor Homo sapiens 131-134 32736658-1 2020 BACKGROUND: Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. Polycyclic Aromatic Hydrocarbons 12-43 aryl hydrocarbon receptor repressor Homo sapiens 145-180 32736658-1 2020 BACKGROUND: Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. Polycyclic Aromatic Hydrocarbons 12-43 aryl hydrocarbon receptor repressor Homo sapiens 182-186 32736658-1 2020 BACKGROUND: Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. Polycyclic Aromatic Hydrocarbons 45-48 aryl hydrocarbon receptor Homo sapiens 104-129 32736658-1 2020 BACKGROUND: Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. Polycyclic Aromatic Hydrocarbons 45-48 aryl hydrocarbon receptor Homo sapiens 131-134 32736658-1 2020 BACKGROUND: Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. Polycyclic Aromatic Hydrocarbons 45-48 aryl hydrocarbon receptor repressor Homo sapiens 145-180 32736658-1 2020 BACKGROUND: Polycyclic aromatic hydrocarbon (PAH)-rich substances like cigarette smoke and PM2.5 induce aryl hydrocarbon receptor (AHR)-mediated aryl hydrocarbon receptor repressor (AHRR) methylation. Polycyclic Aromatic Hydrocarbons 45-48 aryl hydrocarbon receptor repressor Homo sapiens 182-186 32444470-7 2020 Formation of the downstream intermediate cis-2-carboxycyclohexylacetyl-CoA, which is the substrate for the previously described lower degradation pathway leading to the central metabolism, completes the anaerobic degradation pathway of naphthalene.IMPORTANCE Anaerobic degradation of polycyclic aromatic hydrocarbons is poorly investigated despite its significance in anoxic sediments. Polycyclic Aromatic Hydrocarbons 284-316 suppressor of cytokine signaling 2 Homo sapiens 41-46 32418891-0 2020 "Real life" polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines. Polycyclic Aromatic Hydrocarbons 12-43 placental growth factor Homo sapiens 81-86 32418891-0 2020 "Real life" polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines. Polycyclic Aromatic Hydrocarbons 12-43 matrix metallopeptidase 2 Homo sapiens 133-138 32418891-0 2020 "Real life" polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines. Polycyclic Aromatic Hydrocarbons 12-43 matrix metallopeptidase 9 Homo sapiens 142-147 32418891-0 2020 "Real life" polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines. Polycyclic Aromatic Hydrocarbons 12-43 vascular endothelial growth factor A Homo sapiens 152-156 32418891-0 2020 "Real life" polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines. Polycyclic Aromatic Hydrocarbons 45-48 galectin 1 Homo sapiens 73-76 32418891-0 2020 "Real life" polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines. Polycyclic Aromatic Hydrocarbons 45-48 placental growth factor Homo sapiens 81-86 32418891-0 2020 "Real life" polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines. Polycyclic Aromatic Hydrocarbons 45-48 matrix metallopeptidase 2 Homo sapiens 133-138 32418891-0 2020 "Real life" polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines. Polycyclic Aromatic Hydrocarbons 45-48 matrix metallopeptidase 9 Homo sapiens 142-147 32418891-0 2020 "Real life" polycyclic aromatic hydrocarbon (PAH) mixtures modulate hCG, hPL and hPLGF levels and disrupt the physiological ratio of MMP-2 to MMP-9 and VEGF expression in human placenta cell lines. Polycyclic Aromatic Hydrocarbons 45-48 vascular endothelial growth factor A Homo sapiens 152-156 32418891-3 2020 Under basal conditions, the PAH mixtures increased hCG and decreased hPLGF levels in both cell lines, while hPL expression was stimulated in JEG-3 and inhibited in BeWo. Polycyclic Aromatic Hydrocarbons 28-31 placental growth factor Homo sapiens 69-74 32418891-3 2020 Under basal conditions, the PAH mixtures increased hCG and decreased hPLGF levels in both cell lines, while hPL expression was stimulated in JEG-3 and inhibited in BeWo. Polycyclic Aromatic Hydrocarbons 28-31 galectin 1 Homo sapiens 69-72 32418891-5 2020 In hormone-stimulated cells, PAH mixtures changed the MMP-2/MMP-9 ratio in JEG-3 cells in favor of MMP-9, while in BeWo MMP-2 was favored. Polycyclic Aromatic Hydrocarbons 29-32 matrix metallopeptidase 2 Homo sapiens 54-59 32418891-5 2020 In hormone-stimulated cells, PAH mixtures changed the MMP-2/MMP-9 ratio in JEG-3 cells in favor of MMP-9, while in BeWo MMP-2 was favored. Polycyclic Aromatic Hydrocarbons 29-32 matrix metallopeptidase 9 Homo sapiens 60-65 32418891-5 2020 In hormone-stimulated cells, PAH mixtures changed the MMP-2/MMP-9 ratio in JEG-3 cells in favor of MMP-9, while in BeWo MMP-2 was favored. Polycyclic Aromatic Hydrocarbons 29-32 matrix metallopeptidase 9 Homo sapiens 99-104 32418891-5 2020 In hormone-stimulated cells, PAH mixtures changed the MMP-2/MMP-9 ratio in JEG-3 cells in favor of MMP-9, while in BeWo MMP-2 was favored. Polycyclic Aromatic Hydrocarbons 29-32 matrix metallopeptidase 2 Homo sapiens 120-125 32418891-11 2020 Considering that the evaluated protein hormones play crucial roles in angiogenesis and neovascularization in the placenta, "real life" PAH mixtures by disrupting protein hormones levels, the MMP-2/MMP-9 ratio and VEGF expression can lead to insufficiency and many pregnancy-related disorders. Polycyclic Aromatic Hydrocarbons 135-138 matrix metallopeptidase 2 Homo sapiens 191-196 32418891-11 2020 Considering that the evaluated protein hormones play crucial roles in angiogenesis and neovascularization in the placenta, "real life" PAH mixtures by disrupting protein hormones levels, the MMP-2/MMP-9 ratio and VEGF expression can lead to insufficiency and many pregnancy-related disorders. Polycyclic Aromatic Hydrocarbons 135-138 matrix metallopeptidase 9 Homo sapiens 197-202 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 67-99 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 67-99 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 67-99 aryl hydrocarbon receptor Homo sapiens 180-205 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 67-99 aryl hydrocarbon receptor Homo sapiens 207-210 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 67-99 aryl hydrocarbon receptor Homo sapiens 212-215 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 67-99 aryl hydrocarbon receptor nuclear translocator Homo sapiens 238-242 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 101-105 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 101-105 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 101-105 aryl hydrocarbon receptor Homo sapiens 180-205 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 101-105 aryl hydrocarbon receptor Homo sapiens 207-210 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 101-105 aryl hydrocarbon receptor Homo sapiens 212-215 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 101-105 aryl hydrocarbon receptor nuclear translocator Homo sapiens 238-242 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 269-273 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-19 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 269-273 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-27 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 269-273 aryl hydrocarbon receptor Homo sapiens 180-205 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 269-273 aryl hydrocarbon receptor Homo sapiens 207-210 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 269-273 aryl hydrocarbon receptor Homo sapiens 212-215 32409577-1 2020 Cytochrome P450 1A1 (CYP1A1) catalyzes the metabolic activation of polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P) and is transcriptionally regulated by the aryl hydrocarbon receptor (AhR)/AhR nuclear translocator (ARNT) complex upon exposure to PAHs. Polycyclic Aromatic Hydrocarbons 269-273 aryl hydrocarbon receptor nuclear translocator Homo sapiens 238-242 32577782-2 2020 Gas chromatography-mass spectrometry analysis of SPM revealed a mixture of PAH from different origins and a seasonal variation of PAH primary source for the studied area. Polycyclic Aromatic Hydrocarbons 75-78 gastrin Homo sapiens 0-3 32577782-2 2020 Gas chromatography-mass spectrometry analysis of SPM revealed a mixture of PAH from different origins and a seasonal variation of PAH primary source for the studied area. Polycyclic Aromatic Hydrocarbons 130-133 gastrin Homo sapiens 0-3 32801466-2 2020 PM contains polycyclic aromatic hydrocarbons, and they act as the agonists of aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 12-44 aryl hydrocarbon receptor Homo sapiens 78-103 32801466-2 2020 PM contains polycyclic aromatic hydrocarbons, and they act as the agonists of aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 12-44 aryl hydrocarbon receptor Homo sapiens 105-108 32354640-2 2020 The AHR is activated upon binding of polycyclic aromatic hydrocarbons (PAHs), persistent organic pollutants (POPs), and related ubiquitous environmental chemicals, to mediate their biological and toxic effects. Polycyclic Aromatic Hydrocarbons 37-69 aryl hydrocarbon receptor Homo sapiens 4-7 32354640-2 2020 The AHR is activated upon binding of polycyclic aromatic hydrocarbons (PAHs), persistent organic pollutants (POPs), and related ubiquitous environmental chemicals, to mediate their biological and toxic effects. Polycyclic Aromatic Hydrocarbons 71-75 aryl hydrocarbon receptor Homo sapiens 4-7 32354640-5 2020 PM containing PAHs are of increasing concern as a class of agonists, which can activate the AHR. Polycyclic Aromatic Hydrocarbons 14-18 aryl hydrocarbon receptor Homo sapiens 92-95 32384158-1 2020 The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 142-146 aryl hydrocarbon receptor 1a Danio rerio 31-34 32384158-1 2020 The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 108-140 aryl hydrocarbon receptor 1a Danio rerio 4-29 32384158-1 2020 The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 108-140 aryl hydrocarbon receptor 1a Danio rerio 31-34 32384158-1 2020 The aryl hydrocarbon receptor (AHR) mediates developmental toxicity of several xenobiotic classes including polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 142-146 aryl hydrocarbon receptor 1a Danio rerio 4-29 32229384-8 2020 Benzo[a]pyrene-equivalent toxic concentrations (BaPeq) of the Sigma17 PAHs ranged from 0.07 ng L-1 to 2.26 ng L-1 (0.62 +- 0.52 ng L-1, mean +- standard deviation) with a median of 0.47 ng L-1. Polycyclic Aromatic Hydrocarbons 70-74 L1 cell adhesion molecule Homo sapiens 95-98 32229384-8 2020 Benzo[a]pyrene-equivalent toxic concentrations (BaPeq) of the Sigma17 PAHs ranged from 0.07 ng L-1 to 2.26 ng L-1 (0.62 +- 0.52 ng L-1, mean +- standard deviation) with a median of 0.47 ng L-1. Polycyclic Aromatic Hydrocarbons 70-74 L1 cell adhesion molecule Homo sapiens 110-113 32229384-8 2020 Benzo[a]pyrene-equivalent toxic concentrations (BaPeq) of the Sigma17 PAHs ranged from 0.07 ng L-1 to 2.26 ng L-1 (0.62 +- 0.52 ng L-1, mean +- standard deviation) with a median of 0.47 ng L-1. Polycyclic Aromatic Hydrocarbons 70-74 L1 cell adhesion molecule Homo sapiens 110-113 32229384-8 2020 Benzo[a]pyrene-equivalent toxic concentrations (BaPeq) of the Sigma17 PAHs ranged from 0.07 ng L-1 to 2.26 ng L-1 (0.62 +- 0.52 ng L-1, mean +- standard deviation) with a median of 0.47 ng L-1. Polycyclic Aromatic Hydrocarbons 70-74 L1 cell adhesion molecule Homo sapiens 110-113 32224369-6 2020 Ship/vehicle emission and mixed combustion were identified as the main sources of PAHs using diagnostic PAH concentration ratios and principal component analysis-multiple linear regression. Polycyclic Aromatic Hydrocarbons 82-86 inositol polyphosphate-5-phosphatase D Homo sapiens 0-4 32224369-6 2020 Ship/vehicle emission and mixed combustion were identified as the main sources of PAHs using diagnostic PAH concentration ratios and principal component analysis-multiple linear regression. Polycyclic Aromatic Hydrocarbons 82-85 inositol polyphosphate-5-phosphatase D Homo sapiens 0-4 32392058-0 2020 Electron Spin Densities and Density Functional Approximations: Open-Shell Polycyclic Aromatic Hydrocarbons as case study. Polycyclic Aromatic Hydrocarbons 74-106 spindlin 1 Homo sapiens 9-13 32608839-5 2020 The total concentration of PAHs was in the range of 37.27 to 285.88 ng L-1 with a mean value of 78.31 ng L-1, while the monomer concentration of PAHs ranged from 0 to 61.35 ng L-1. Polycyclic Aromatic Hydrocarbons 27-31 L1 cell adhesion molecule Homo sapiens 71-74 32289583-0 2020 Elevated expression of AhR and NLRP3 link polycyclic aromatic hydrocarbon exposure to cytokine storm in preschool children. Polycyclic Aromatic Hydrocarbons 42-73 aryl hydrocarbon receptor Homo sapiens 23-26 32289583-0 2020 Elevated expression of AhR and NLRP3 link polycyclic aromatic hydrocarbon exposure to cytokine storm in preschool children. Polycyclic Aromatic Hydrocarbons 42-73 NLR family pyrin domain containing 3 Homo sapiens 31-36 32289583-11 2020 After adjusting for age, gender, BMI, family income, parental education level, and second-hand smoke exposure, we found that increased PAH exposure was associated with higher AhR and NLRP3 expression and elevated IL-4, IL-10, IL-12p70, IL-18, IL-22, IL-23, TNF-alpha, and IFN-gamma levels. Polycyclic Aromatic Hydrocarbons 135-138 aryl hydrocarbon receptor Homo sapiens 175-178 32289583-11 2020 After adjusting for age, gender, BMI, family income, parental education level, and second-hand smoke exposure, we found that increased PAH exposure was associated with higher AhR and NLRP3 expression and elevated IL-4, IL-10, IL-12p70, IL-18, IL-22, IL-23, TNF-alpha, and IFN-gamma levels. Polycyclic Aromatic Hydrocarbons 135-138 NLR family pyrin domain containing 3 Homo sapiens 183-188 32289583-11 2020 After adjusting for age, gender, BMI, family income, parental education level, and second-hand smoke exposure, we found that increased PAH exposure was associated with higher AhR and NLRP3 expression and elevated IL-4, IL-10, IL-12p70, IL-18, IL-22, IL-23, TNF-alpha, and IFN-gamma levels. Polycyclic Aromatic Hydrocarbons 135-138 interleukin 4 Homo sapiens 213-217 32289583-11 2020 After adjusting for age, gender, BMI, family income, parental education level, and second-hand smoke exposure, we found that increased PAH exposure was associated with higher AhR and NLRP3 expression and elevated IL-4, IL-10, IL-12p70, IL-18, IL-22, IL-23, TNF-alpha, and IFN-gamma levels. Polycyclic Aromatic Hydrocarbons 135-138 interleukin 10 Homo sapiens 219-224 32289583-11 2020 After adjusting for age, gender, BMI, family income, parental education level, and second-hand smoke exposure, we found that increased PAH exposure was associated with higher AhR and NLRP3 expression and elevated IL-4, IL-10, IL-12p70, IL-18, IL-22, IL-23, TNF-alpha, and IFN-gamma levels. Polycyclic Aromatic Hydrocarbons 135-138 interleukin 18 Homo sapiens 236-241 32289583-11 2020 After adjusting for age, gender, BMI, family income, parental education level, and second-hand smoke exposure, we found that increased PAH exposure was associated with higher AhR and NLRP3 expression and elevated IL-4, IL-10, IL-12p70, IL-18, IL-22, IL-23, TNF-alpha, and IFN-gamma levels. Polycyclic Aromatic Hydrocarbons 135-138 interleukin 22 Homo sapiens 243-248 32289583-11 2020 After adjusting for age, gender, BMI, family income, parental education level, and second-hand smoke exposure, we found that increased PAH exposure was associated with higher AhR and NLRP3 expression and elevated IL-4, IL-10, IL-12p70, IL-18, IL-22, IL-23, TNF-alpha, and IFN-gamma levels. Polycyclic Aromatic Hydrocarbons 135-138 interleukin 23 subunit alpha Homo sapiens 250-255 32289583-11 2020 After adjusting for age, gender, BMI, family income, parental education level, and second-hand smoke exposure, we found that increased PAH exposure was associated with higher AhR and NLRP3 expression and elevated IL-4, IL-10, IL-12p70, IL-18, IL-22, IL-23, TNF-alpha, and IFN-gamma levels. Polycyclic Aromatic Hydrocarbons 135-138 tumor necrosis factor Homo sapiens 257-266 32289583-11 2020 After adjusting for age, gender, BMI, family income, parental education level, and second-hand smoke exposure, we found that increased PAH exposure was associated with higher AhR and NLRP3 expression and elevated IL-4, IL-10, IL-12p70, IL-18, IL-22, IL-23, TNF-alpha, and IFN-gamma levels. Polycyclic Aromatic Hydrocarbons 135-138 interferon gamma Homo sapiens 272-281 32289583-12 2020 The associations between PAH exposure and IL-1beta, IL-18, IFN-gamma, and TNF-beta were mediated by NLRP3 expression, and the relationships between PAH exposure and IL-4, IL-10, IL-12p70, IL-22, IL-23, and TNF-alpha were mediated by AhR expression. Polycyclic Aromatic Hydrocarbons 25-28 interleukin 1 alpha Homo sapiens 42-50 32289583-12 2020 The associations between PAH exposure and IL-1beta, IL-18, IFN-gamma, and TNF-beta were mediated by NLRP3 expression, and the relationships between PAH exposure and IL-4, IL-10, IL-12p70, IL-22, IL-23, and TNF-alpha were mediated by AhR expression. Polycyclic Aromatic Hydrocarbons 25-28 interleukin 18 Homo sapiens 52-57 32289583-12 2020 The associations between PAH exposure and IL-1beta, IL-18, IFN-gamma, and TNF-beta were mediated by NLRP3 expression, and the relationships between PAH exposure and IL-4, IL-10, IL-12p70, IL-22, IL-23, and TNF-alpha were mediated by AhR expression. Polycyclic Aromatic Hydrocarbons 25-28 interferon gamma Homo sapiens 59-68 32289583-12 2020 The associations between PAH exposure and IL-1beta, IL-18, IFN-gamma, and TNF-beta were mediated by NLRP3 expression, and the relationships between PAH exposure and IL-4, IL-10, IL-12p70, IL-22, IL-23, and TNF-alpha were mediated by AhR expression. Polycyclic Aromatic Hydrocarbons 25-28 tumor necrosis factor Homo sapiens 74-82 32289583-12 2020 The associations between PAH exposure and IL-1beta, IL-18, IFN-gamma, and TNF-beta were mediated by NLRP3 expression, and the relationships between PAH exposure and IL-4, IL-10, IL-12p70, IL-22, IL-23, and TNF-alpha were mediated by AhR expression. Polycyclic Aromatic Hydrocarbons 25-28 NLR family pyrin domain containing 3 Homo sapiens 100-105 32289583-12 2020 The associations between PAH exposure and IL-1beta, IL-18, IFN-gamma, and TNF-beta were mediated by NLRP3 expression, and the relationships between PAH exposure and IL-4, IL-10, IL-12p70, IL-22, IL-23, and TNF-alpha were mediated by AhR expression. Polycyclic Aromatic Hydrocarbons 25-28 interleukin 22 Homo sapiens 188-193 32289583-12 2020 The associations between PAH exposure and IL-1beta, IL-18, IFN-gamma, and TNF-beta were mediated by NLRP3 expression, and the relationships between PAH exposure and IL-4, IL-10, IL-12p70, IL-22, IL-23, and TNF-alpha were mediated by AhR expression. Polycyclic Aromatic Hydrocarbons 25-28 interleukin 23 subunit alpha Homo sapiens 195-200 32289583-12 2020 The associations between PAH exposure and IL-1beta, IL-18, IFN-gamma, and TNF-beta were mediated by NLRP3 expression, and the relationships between PAH exposure and IL-4, IL-10, IL-12p70, IL-22, IL-23, and TNF-alpha were mediated by AhR expression. Polycyclic Aromatic Hydrocarbons 25-28 tumor necrosis factor Homo sapiens 206-215 32289583-12 2020 The associations between PAH exposure and IL-1beta, IL-18, IFN-gamma, and TNF-beta were mediated by NLRP3 expression, and the relationships between PAH exposure and IL-4, IL-10, IL-12p70, IL-22, IL-23, and TNF-alpha were mediated by AhR expression. Polycyclic Aromatic Hydrocarbons 25-28 aryl hydrocarbon receptor Homo sapiens 233-236 32289583-12 2020 The associations between PAH exposure and IL-1beta, IL-18, IFN-gamma, and TNF-beta were mediated by NLRP3 expression, and the relationships between PAH exposure and IL-4, IL-10, IL-12p70, IL-22, IL-23, and TNF-alpha were mediated by AhR expression. Polycyclic Aromatic Hydrocarbons 148-151 interleukin 4 Homo sapiens 165-169 32289583-13 2020 CONCLUSIONS: Our findings suggest that the association between PAH exposure and a cytokine storm may be mediated by AhR and NLRP3 expression among preschoolers. Polycyclic Aromatic Hydrocarbons 63-66 aryl hydrocarbon receptor Homo sapiens 116-119 32289583-13 2020 CONCLUSIONS: Our findings suggest that the association between PAH exposure and a cytokine storm may be mediated by AhR and NLRP3 expression among preschoolers. Polycyclic Aromatic Hydrocarbons 63-66 NLR family pyrin domain containing 3 Homo sapiens 124-129 32251684-5 2020 For this reason, we screened for compounds binding to the human estrogen receptor alpha (ERalpha) and identified the PAH compounds indeno[1,2,3-cd]pyrene (Indpy) and picene (Pice) with a high binding affinity. Polycyclic Aromatic Hydrocarbons 117-120 estrogen receptor 1 Homo sapiens 64-87 32251684-11 2020 In conclusion, we showed an ESR1-mediated influence of the PAH compounds Indpy and Pice on the gene expression pattern of MCF-7 cells, possibly also promoting breast cancer development in patients. Polycyclic Aromatic Hydrocarbons 59-62 estrogen receptor 1 Homo sapiens 28-32 32608839-5 2020 The total concentration of PAHs was in the range of 37.27 to 285.88 ng L-1 with a mean value of 78.31 ng L-1, while the monomer concentration of PAHs ranged from 0 to 61.35 ng L-1. Polycyclic Aromatic Hydrocarbons 27-31 L1 cell adhesion molecule Homo sapiens 105-108 32608839-5 2020 The total concentration of PAHs was in the range of 37.27 to 285.88 ng L-1 with a mean value of 78.31 ng L-1, while the monomer concentration of PAHs ranged from 0 to 61.35 ng L-1. Polycyclic Aromatic Hydrocarbons 27-31 L1 cell adhesion molecule Homo sapiens 105-108 32388950-10 2020 The M (P(25), P(75)) of concentration of total urinary PAHs metabolites was 5.72 (3.91,8.72) mug/mmol Cr. Polycyclic Aromatic Hydrocarbons 55-59 tubulin polymerization promoting protein Homo sapiens 7-12 32388950-10 2020 The M (P(25), P(75)) of concentration of total urinary PAHs metabolites was 5.72 (3.91,8.72) mug/mmol Cr. Polycyclic Aromatic Hydrocarbons 55-59 PC4 and SFRS1 interacting protein 1 Homo sapiens 14-19 32112355-1 2020 Polycyclic aromatic hydrocarbons (PAHs)/aryl hydrocarbon receptor (AhR) regulate the expression of target genes, including drug transporter genes which harbor xenobiotic response element (XRE) in their promoter regions. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Rattus norvegicus 67-70 32112355-1 2020 Polycyclic aromatic hydrocarbons (PAHs)/aryl hydrocarbon receptor (AhR) regulate the expression of target genes, including drug transporter genes which harbor xenobiotic response element (XRE) in their promoter regions. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Rattus norvegicus 67-70 31891995-6 2020 Under optimal conditions, the limits of detection for PAHs were achieved within the range of 0.01-0.10 ng L-1. Polycyclic Aromatic Hydrocarbons 54-58 immunoglobulin kappa variable 1-16 Homo sapiens 106-109 32199227-2 2020 OBJECTIVE: The aim of this study was to evaluate exposure levels of atmospheric PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) in an electronic waste (e-waste) polluted town, Guiyu, and to investigate the associations between PM2.5-PAH exposure, insulin-like growth factor 1 (IGF-1) levels and child growth. Polycyclic Aromatic Hydrocarbons 126-130 insulin like growth factor 1 Homo sapiens 251-279 32199227-2 2020 OBJECTIVE: The aim of this study was to evaluate exposure levels of atmospheric PM2.5-bound polycyclic aromatic hydrocarbons (PAHs) in an electronic waste (e-waste) polluted town, Guiyu, and to investigate the associations between PM2.5-PAH exposure, insulin-like growth factor 1 (IGF-1) levels and child growth. Polycyclic Aromatic Hydrocarbons 126-130 insulin like growth factor 1 Homo sapiens 281-286 32053282-2 2020 The binding affinities obtained for the encapsulation of the planar PAHs guests in CD2 Cl2 are found to exponentially increase with the number of pi-electrons of the guest (1.3 > logK >6.6). Polycyclic Aromatic Hydrocarbons 68-72 CD2 molecule Homo sapiens 83-86 31950421-8 2020 Engine fueled with B5, B10, and B15 mainly exhausts low molecular weight polycyclic aromatic hydrocarbons (PAHs) (ring number <= 4) which are closely related to unburned fuel, and the total PAH emissions are linear versus the fuel consumption. Polycyclic Aromatic Hydrocarbons 73-105 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 23-26 31950421-8 2020 Engine fueled with B5, B10, and B15 mainly exhausts low molecular weight polycyclic aromatic hydrocarbons (PAHs) (ring number <= 4) which are closely related to unburned fuel, and the total PAH emissions are linear versus the fuel consumption. Polycyclic Aromatic Hydrocarbons 73-105 NADH:ubiquinone oxidoreductase subunit B4 Homo sapiens 32-35 31950421-8 2020 Engine fueled with B5, B10, and B15 mainly exhausts low molecular weight polycyclic aromatic hydrocarbons (PAHs) (ring number <= 4) which are closely related to unburned fuel, and the total PAH emissions are linear versus the fuel consumption. Polycyclic Aromatic Hydrocarbons 107-111 ectonucleotide pyrophosphatase/phosphodiesterase 3 Homo sapiens 23-26 31950421-8 2020 Engine fueled with B5, B10, and B15 mainly exhausts low molecular weight polycyclic aromatic hydrocarbons (PAHs) (ring number <= 4) which are closely related to unburned fuel, and the total PAH emissions are linear versus the fuel consumption. Polycyclic Aromatic Hydrocarbons 107-111 NADH:ubiquinone oxidoreductase subunit B4 Homo sapiens 32-35 32275572-0 2020 Polycyclic aromatic hydrocarbons in surface sediments of the Aegean Sea (eastern Mediterranean Sea). Polycyclic Aromatic Hydrocarbons 0-32 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 68-71 32275572-0 2020 Polycyclic aromatic hydrocarbons in surface sediments of the Aegean Sea (eastern Mediterranean Sea). Polycyclic Aromatic Hydrocarbons 0-32 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 95-98 32265041-1 2020 Diet is a major source of human exposure to polycyclic aromatic hydrocarbons (PAHs), of which benzo[a]pyrene (BaP) is the most commonly studied and measured. Polycyclic Aromatic Hydrocarbons 44-76 prohibitin 2 Homo sapiens 110-113 32265041-1 2020 Diet is a major source of human exposure to polycyclic aromatic hydrocarbons (PAHs), of which benzo[a]pyrene (BaP) is the most commonly studied and measured. Polycyclic Aromatic Hydrocarbons 78-82 prohibitin 2 Homo sapiens 110-113 32522345-1 2020 The aryl hydrocarbon receptor (AhR) transcription factor is activated by polycyclic aromatic hydrocarbons (PAH) and other ligands. Polycyclic Aromatic Hydrocarbons 73-105 aryl hydrocarbon receptor Homo sapiens 4-29 32522345-1 2020 The aryl hydrocarbon receptor (AhR) transcription factor is activated by polycyclic aromatic hydrocarbons (PAH) and other ligands. Polycyclic Aromatic Hydrocarbons 73-105 aryl hydrocarbon receptor Homo sapiens 31-34 32522345-1 2020 The aryl hydrocarbon receptor (AhR) transcription factor is activated by polycyclic aromatic hydrocarbons (PAH) and other ligands. Polycyclic Aromatic Hydrocarbons 107-110 aryl hydrocarbon receptor Homo sapiens 4-29 32522345-1 2020 The aryl hydrocarbon receptor (AhR) transcription factor is activated by polycyclic aromatic hydrocarbons (PAH) and other ligands. Polycyclic Aromatic Hydrocarbons 107-110 aryl hydrocarbon receptor Homo sapiens 31-34 31870161-0 2020 Interaction of RARB Variant with Polycyclic Aromatic Hydrocarbons Exposure on Annual Lung Function Change. Polycyclic Aromatic Hydrocarbons 33-65 retinoic acid receptor beta Homo sapiens 15-19 31699563-0 2020 Study on the molecular interactions of hydroxylated polycyclic aromatic hydrocarbons with catalase using multi-spectral methods combined with molecular docking. Polycyclic Aromatic Hydrocarbons 52-84 catalase Homo sapiens 90-98 31773853-2 2020 Results show that the transport properties of PAHs are dependent on whether the number of benzene rings in the width direction is odd or even. Polycyclic Aromatic Hydrocarbons 46-50 odd-skipped related transcription factor 1 Homo sapiens 130-133 31773853-4 2020 PAHs with an odd number of rings exhibit poor transport properties while the even-ringed PAHs show excellent transport properties coupled with a negative differential resistance (NDR) effect. Polycyclic Aromatic Hydrocarbons 0-4 odd-skipped related transcription factor 1 Homo sapiens 13-16 32256855-1 2020 Hexa-peri-hexabenzocoronene (HBC) is known to be a poorly soluble polycyclic aromatic hydrocarbon for which direct functionalization methods have been very limited. Polycyclic Aromatic Hydrocarbons 66-97 hexosaminidase subunit alpha Homo sapiens 0-4 32131765-1 2020 BACKGROUND: CYP2A6 is an enzyme involved in oxidation of a number of environmental chemicals, including nicotine, pro-carcinogenic nitrosamines and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 148-180 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 12-18 32131765-1 2020 BACKGROUND: CYP2A6 is an enzyme involved in oxidation of a number of environmental chemicals, including nicotine, pro-carcinogenic nitrosamines and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 182-186 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 12-18 32022550-0 2020 The Inhibited Nitric Oxide Production of Human Endothelial Nitric Oxide Synthase by Nitrated and Oxygenated Polycyclic Aromatic Hydrocarbons. Polycyclic Aromatic Hydrocarbons 108-140 nitric oxide synthase 3 Homo sapiens 47-80 31872513-1 2020 A unified low temperature reaction mechanism on the formation of acenes, phenacenes, and helicenes - polycyclic aromatic hydrocarbons (PAHs) that are distinct via the linear, zig-zag, and ortho-condensed arrangements of fused benzene rings - is revealed. Polycyclic Aromatic Hydrocarbons 101-133 alpha-2-glycoprotein 1, zinc-binding Homo sapiens 179-182 31872513-1 2020 A unified low temperature reaction mechanism on the formation of acenes, phenacenes, and helicenes - polycyclic aromatic hydrocarbons (PAHs) that are distinct via the linear, zig-zag, and ortho-condensed arrangements of fused benzene rings - is revealed. Polycyclic Aromatic Hydrocarbons 135-139 alpha-2-glycoprotein 1, zinc-binding Homo sapiens 179-182 31944002-1 2020 BACKGROUND: Previous studies suggested associations between maternal smoking, a source of exposure to polycyclic aromatic hydrocarbons (PAHs) and other chemicals, and central nervous system and face birth defects; however, no previous studies have evaluated maternal occupational PAH exposure itself. Polycyclic Aromatic Hydrocarbons 102-134 phenylalanine hydroxylase Homo sapiens 136-139 31836608-2 2020 The detoxification of PAHs by glucuronidation is well-characterized for the UDP-glycosyltransferase (UGT) 1A, 2A, and 2B subfamilies; however, the role of the UGT3A subfamily in PAH metabolism remains poorly understood. Polycyclic Aromatic Hydrocarbons 22-26 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 76-120 31836608-5 2020 In vitro metabolism assays using UGT3A2-overexpressing cell microsomes indicated that UGT3A2 exhibits glycosylation activity against all of the simple and complex PAHs tested. Polycyclic Aromatic Hydrocarbons 163-167 UDP glycosyltransferase family 3 member A2 Homo sapiens 33-39 31836608-5 2020 In vitro metabolism assays using UGT3A2-overexpressing cell microsomes indicated that UGT3A2 exhibits glycosylation activity against all of the simple and complex PAHs tested. Polycyclic Aromatic Hydrocarbons 163-167 UDP glycosyltransferase family 3 member A2 Homo sapiens 86-92 31836608-6 2020 The Vmax/Km ratios for UGT3A2 activity with UDP-xylose vs. UDP-glucose as cosubstrate ranged from 0.71-4.0 for all PAHs tested, demonstrating that PAH glycosylation may be occurring at rates up to four-fold higher with UDP-xylose than UDP-glucose. Polycyclic Aromatic Hydrocarbons 115-119 UDP glycosyltransferase family 3 member A2 Homo sapiens 23-29 31836608-7 2020 Limited glycosylation activity was observed against PAHs with UGT3A1-overexpressing cell microsomes. Polycyclic Aromatic Hydrocarbons 52-56 UDP glycosyltransferase family 3 member A1 Homo sapiens 62-68 31836608-10 2020 These data suggest that UGT3A2 plays an important role in the detoxification of PAHs in aerodigestive tract tissues, and that there may be cosubstrate dependent differences in the detoxification of PAHs by UGT3A2. Polycyclic Aromatic Hydrocarbons 80-84 UDP glycosyltransferase family 3 member A2 Homo sapiens 24-30 31836608-10 2020 These data suggest that UGT3A2 plays an important role in the detoxification of PAHs in aerodigestive tract tissues, and that there may be cosubstrate dependent differences in the detoxification of PAHs by UGT3A2. Polycyclic Aromatic Hydrocarbons 198-202 UDP glycosyltransferase family 3 member A2 Homo sapiens 206-212 31836608-11 2020 SIGNIFICANCE STATEMENT: UGT3A2 is highly active against PAHs with either UDP-glucose or UDP-xylose as a cosubstrate. Polycyclic Aromatic Hydrocarbons 56-60 UDP glycosyltransferase family 3 member A2 Homo sapiens 24-30 31836608-12 2020 UGT3A1 exhibited low levels of activity against PAHs. Polycyclic Aromatic Hydrocarbons 48-52 UDP glycosyltransferase family 3 member A1 Homo sapiens 0-6 31836608-14 2020 UGT3A2 may be an important detoxifier of PAHs in humans. Polycyclic Aromatic Hydrocarbons 41-45 UDP glycosyltransferase family 3 member A2 Homo sapiens 0-6 31818624-0 2020 Polycyclic aromatic hydrocarbons exposure and their joint effects with age, smoking, and TCL1A variants on mosaic loss of chromosome Y among coke-oven workers. Polycyclic Aromatic Hydrocarbons 0-32 TCL1 family AKT coactivator A Homo sapiens 89-94 32004873-5 2020 The nPM lacks water-insoluble PAHs (polycyclic aromatic hydrocarbons) and is depleted by >50% in bioactive metals (e.g., copper, iron, nickel), inorganic ions, black carbon, and other organic compounds. Polycyclic Aromatic Hydrocarbons 30-34 nucleophosmin 1 Homo sapiens 4-7 32004873-5 2020 The nPM lacks water-insoluble PAHs (polycyclic aromatic hydrocarbons) and is depleted by >50% in bioactive metals (e.g., copper, iron, nickel), inorganic ions, black carbon, and other organic compounds. Polycyclic Aromatic Hydrocarbons 36-68 nucleophosmin 1 Homo sapiens 4-7 32007923-5 2020 In cells exposed to dichloromethane extracts, IL-1beta secretion was significantly correlated with polycyclic aromatic hydrocarbons (PAHs); meanwhile, tumor necrosis factor (TNF)-alpha secretion was negatively associated with secondary nitrated PAHs, suggesting that atmospheric nitration process might modify the biological effects of PM2.5 components. Polycyclic Aromatic Hydrocarbons 99-131 interleukin 1 alpha Homo sapiens 46-54 32007923-5 2020 In cells exposed to dichloromethane extracts, IL-1beta secretion was significantly correlated with polycyclic aromatic hydrocarbons (PAHs); meanwhile, tumor necrosis factor (TNF)-alpha secretion was negatively associated with secondary nitrated PAHs, suggesting that atmospheric nitration process might modify the biological effects of PM2.5 components. Polycyclic Aromatic Hydrocarbons 133-137 interleukin 1 alpha Homo sapiens 46-54 32007923-5 2020 In cells exposed to dichloromethane extracts, IL-1beta secretion was significantly correlated with polycyclic aromatic hydrocarbons (PAHs); meanwhile, tumor necrosis factor (TNF)-alpha secretion was negatively associated with secondary nitrated PAHs, suggesting that atmospheric nitration process might modify the biological effects of PM2.5 components. Polycyclic Aromatic Hydrocarbons 245-249 interleukin 1 alpha Homo sapiens 46-54 32007923-5 2020 In cells exposed to dichloromethane extracts, IL-1beta secretion was significantly correlated with polycyclic aromatic hydrocarbons (PAHs); meanwhile, tumor necrosis factor (TNF)-alpha secretion was negatively associated with secondary nitrated PAHs, suggesting that atmospheric nitration process might modify the biological effects of PM2.5 components. Polycyclic Aromatic Hydrocarbons 245-249 tumor necrosis factor Homo sapiens 151-184 31698960-0 2020 Environmental polycyclic aromatic hydrocarbons mixture, in human blood levels, decreased oestradiol secretion by granulosa cells via ESR1 and GPER1 but not ESR2 receptor. Polycyclic Aromatic Hydrocarbons 14-46 estrogen receptor 1 Homo sapiens 133-137 31698960-0 2020 Environmental polycyclic aromatic hydrocarbons mixture, in human blood levels, decreased oestradiol secretion by granulosa cells via ESR1 and GPER1 but not ESR2 receptor. Polycyclic Aromatic Hydrocarbons 14-46 G protein-coupled estrogen receptor 1 Homo sapiens 142-147 31698960-7 2020 This study showed that both classic ESR1 and GPER1 were involved in the inhibitory effect of both PAH mixtures on E2 secretion and confirmed that expression of P450arom could be downregulated through the aryl hydrocarbon receptor and additionally through the ESR2. Polycyclic Aromatic Hydrocarbons 98-101 estrogen receptor 1 Homo sapiens 36-40 31698960-7 2020 This study showed that both classic ESR1 and GPER1 were involved in the inhibitory effect of both PAH mixtures on E2 secretion and confirmed that expression of P450arom could be downregulated through the aryl hydrocarbon receptor and additionally through the ESR2. Polycyclic Aromatic Hydrocarbons 98-101 G protein-coupled estrogen receptor 1 Homo sapiens 45-50 31698960-7 2020 This study showed that both classic ESR1 and GPER1 were involved in the inhibitory effect of both PAH mixtures on E2 secretion and confirmed that expression of P450arom could be downregulated through the aryl hydrocarbon receptor and additionally through the ESR2. Polycyclic Aromatic Hydrocarbons 98-101 aryl hydrocarbon receptor Homo sapiens 204-229 31698960-7 2020 This study showed that both classic ESR1 and GPER1 were involved in the inhibitory effect of both PAH mixtures on E2 secretion and confirmed that expression of P450arom could be downregulated through the aryl hydrocarbon receptor and additionally through the ESR2. Polycyclic Aromatic Hydrocarbons 98-101 estrogen receptor 2 Homo sapiens 259-263 32098176-5 2020 In addition, among the measured physicochemical properties, the soil organic carbon (SOC) had the greatest influence on PAHs, while soil particle size distribution had the smallest effect. Polycyclic Aromatic Hydrocarbons 120-124 UBX domain protein 11 Homo sapiens 64-89 32093017-7 2020 The time correlation between PAH action and AhR mRNA expression suggested that Ci-AhR could be associated with PAH metabolism. Polycyclic Aromatic Hydrocarbons 29-32 transcription factor protein Ciona intestinalis 44-47 32093017-7 2020 The time correlation between PAH action and AhR mRNA expression suggested that Ci-AhR could be associated with PAH metabolism. Polycyclic Aromatic Hydrocarbons 111-114 transcription factor protein Ciona intestinalis 44-47 31585293-6 2020 The results indicated that the total concentration of 15 of the 16 PAHs that are prioritized by U.S. EPA (excluding naphthalene) ( 15PAHs) was significantly higher in the coastal tissues (173 +- 314 ng g-1 dw) than in the offshore tissues (71 +- 109 ng g-1 dw), as well as in coastal seawater (196 +- 96 ng L-1) than in the offshore water (54 +- 9 ng L-1). Polycyclic Aromatic Hydrocarbons 67-71 immunoglobulin kappa variable 1-16 Homo sapiens 307-310 31585293-6 2020 The results indicated that the total concentration of 15 of the 16 PAHs that are prioritized by U.S. EPA (excluding naphthalene) ( 15PAHs) was significantly higher in the coastal tissues (173 +- 314 ng g-1 dw) than in the offshore tissues (71 +- 109 ng g-1 dw), as well as in coastal seawater (196 +- 96 ng L-1) than in the offshore water (54 +- 9 ng L-1). Polycyclic Aromatic Hydrocarbons 67-71 immunoglobulin kappa variable 1-16 Homo sapiens 351-354 31685316-9 2020 OM content impacted on Frap only for PAHs. Polycyclic Aromatic Hydrocarbons 37-41 mechanistic target of rapamycin kinase Homo sapiens 23-27 31525685-2 2020 The applicability of quantitative structure-activity relationship (QSAR) model in predicting TEF of PAHs and TPPs to holistically evaluate the CHHR posed by the exposure to these pollutants in road dust from Gold Coast, Australia was examined. Polycyclic Aromatic Hydrocarbons 100-104 TEF transcription factor, PAR bZIP family member Homo sapiens 93-96 31729560-6 2020 The results showed that HMW-PAHs behaved as net deposition, while LMW-PAHs were more likely to establish dynamic equilibrium between atmosphere and soil than MMW-PAHs and HMW-PAHs. Polycyclic Aromatic Hydrocarbons 28-32 cilia and flagella associated protein 97 Homo sapiens 24-27 31815681-1 2020 We have recently described in this journal our detection of an anthropoid primate-specific, adrenal androgen-dependent, p53-mediated, "kill switch" tumor suppression mechanism that reached its fullest expression only in humans, as a result of human-specific exposure to polycyclic aromatic hydrocarbons caused by the harnessing of fire. Polycyclic Aromatic Hydrocarbons 270-302 tumor protein p53 Homo sapiens 120-123 31753633-0 2020 Novel and specific source identification of PAH in urban soils: Alk-PAH-BPCA index and "V"-shape distribution pattern. Polycyclic Aromatic Hydrocarbons 44-47 Anaplastic lymphoma kinase Drosophila melanogaster 64-67 31753633-0 2020 Novel and specific source identification of PAH in urban soils: Alk-PAH-BPCA index and "V"-shape distribution pattern. Polycyclic Aromatic Hydrocarbons 68-71 Anaplastic lymphoma kinase Drosophila melanogaster 64-67 31767238-4 2020 The concentrations of the dissolved PAHs in surface water from the wet season (average of 161 +- 97 ng L-1) were significantly higher (ANOVA, p < 0.01) than those from the dry season (average of 43 +- 21 ng L-1). Polycyclic Aromatic Hydrocarbons 36-40 immunoglobulin kappa variable 1-16 Homo sapiens 103-106 31767238-4 2020 The concentrations of the dissolved PAHs in surface water from the wet season (average of 161 +- 97 ng L-1) were significantly higher (ANOVA, p < 0.01) than those from the dry season (average of 43 +- 21 ng L-1). Polycyclic Aromatic Hydrocarbons 36-40 immunoglobulin kappa variable 1-16 Homo sapiens 210-213 31889289-0 2020 Analysis of origin, change, and distribution of polycyclic aromatic hydrocarbons in the continental shelf of China Sea. Polycyclic Aromatic Hydrocarbons 48-80 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 115-118 31889289-5 2020 There was a lack of systematic understanding of PAHs in the whole continental shelf sea. Polycyclic Aromatic Hydrocarbons 48-52 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 84-87 31889289-6 2020 In this study, the relevant research findings of PAHs in the continental shelf of China Sea in recent years were systematically summarized. Polycyclic Aromatic Hydrocarbons 49-53 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 88-91 31889289-7 2020 The spatial and temporal variations of PAHs in sediments of China Sea were comprehensively displayed. Polycyclic Aromatic Hydrocarbons 39-43 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 66-69 31655123-1 2020 Cytochrome P4501A1 (CYP1A1) is involved in the metabolism of several genotoxic/carcinogenic environmental xenobiotics including polycyclic aromatic hydrocarbons (PAHs) like benzo[a]pyrene. Polycyclic Aromatic Hydrocarbons 128-160 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-18 31655123-1 2020 Cytochrome P4501A1 (CYP1A1) is involved in the metabolism of several genotoxic/carcinogenic environmental xenobiotics including polycyclic aromatic hydrocarbons (PAHs) like benzo[a]pyrene. Polycyclic Aromatic Hydrocarbons 128-160 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 20-26 31900672-8 2020 The percentage of dispersed PAH concentration per experimental unit ranged from 9.90% in unit P2 to 75.27% in unit P18. Polycyclic Aromatic Hydrocarbons 28-31 H3 histone pseudogene 12 Homo sapiens 115-118 31760614-8 2020 Moreover, the presence of PAHs also negatively impacted the metal bioaccessibility in the soil amended with the BM600, and, on the contrary, positively impacted it in the soil amended with the BM400. Polycyclic Aromatic Hydrocarbons 26-30 laminin subunit alpha 3 Homo sapiens 112-117 33283556-11 2020 Conclusion: CYP1A1 and CYP1B1 are known to cause lung cancer by metabolizing polycyclic aromatic hydrocarbons, and long noncoding RNA is also known to play an important role in lung cancer. Polycyclic Aromatic Hydrocarbons 77-109 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 12-18 33283556-11 2020 Conclusion: CYP1A1 and CYP1B1 are known to cause lung cancer by metabolizing polycyclic aromatic hydrocarbons, and long noncoding RNA is also known to play an important role in lung cancer. Polycyclic Aromatic Hydrocarbons 77-109 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 23-29 32094037-2 2020 CASE SUMMARY: Polycyclic aromatic hydrocarbons present in cigarette smoke are well-known inducers of cytochrome P450 (CYP) enzymes. Polycyclic Aromatic Hydrocarbons 14-46 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 101-116 32094037-2 2020 CASE SUMMARY: Polycyclic aromatic hydrocarbons present in cigarette smoke are well-known inducers of cytochrome P450 (CYP) enzymes. Polycyclic Aromatic Hydrocarbons 14-46 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 118-121 32841893-1 2020 Environmental carcinogen benzo(a)pyrene (BaP) is a representative compound of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 78-110 prohibitin 2 Homo sapiens 41-44 32841893-1 2020 Environmental carcinogen benzo(a)pyrene (BaP) is a representative compound of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 112-116 prohibitin 2 Homo sapiens 41-44 31708028-3 2019 The established method was applied to the determination of polycyclic aromatic hydrocarbons (PAHs), featuring low LODs (i.e., 0.14-0.24 ng L-1) and wide linear ranges (e.g., 10-10000 ng L-1). Polycyclic Aromatic Hydrocarbons 59-91 immunoglobulin kappa variable 1-16 Homo sapiens 139-142 31708028-3 2019 The established method was applied to the determination of polycyclic aromatic hydrocarbons (PAHs), featuring low LODs (i.e., 0.14-0.24 ng L-1) and wide linear ranges (e.g., 10-10000 ng L-1). Polycyclic Aromatic Hydrocarbons 59-91 immunoglobulin kappa variable 1-16 Homo sapiens 186-189 31708028-3 2019 The established method was applied to the determination of polycyclic aromatic hydrocarbons (PAHs), featuring low LODs (i.e., 0.14-0.24 ng L-1) and wide linear ranges (e.g., 10-10000 ng L-1). Polycyclic Aromatic Hydrocarbons 93-97 immunoglobulin kappa variable 1-16 Homo sapiens 139-142 31708028-3 2019 The established method was applied to the determination of polycyclic aromatic hydrocarbons (PAHs), featuring low LODs (i.e., 0.14-0.24 ng L-1) and wide linear ranges (e.g., 10-10000 ng L-1). Polycyclic Aromatic Hydrocarbons 93-97 immunoglobulin kappa variable 1-16 Homo sapiens 186-189 31782482-9 2019 Chemical bonding analyses show isomer II of B41- (Cs, 1A") and isomer VIII of B42- (C1, 2A) are pi aromatic, analogous to that in the polycyclic aromatic hydrocarbon C27H13+ (C2v, 1A1). Polycyclic Aromatic Hydrocarbons 134-173 cytochrome c oxidase subunit 8A Homo sapiens 70-74 31782482-9 2019 Chemical bonding analyses show isomer II of B41- (Cs, 1A") and isomer VIII of B42- (C1, 2A) are pi aromatic, analogous to that in the polycyclic aromatic hydrocarbon C27H13+ (C2v, 1A1). Polycyclic Aromatic Hydrocarbons 134-173 proline rich nuclear receptor coactivator 1 Homo sapiens 78-81 31782482-9 2019 Chemical bonding analyses show isomer II of B41- (Cs, 1A") and isomer VIII of B42- (C1, 2A) are pi aromatic, analogous to that in the polycyclic aromatic hydrocarbon C27H13+ (C2v, 1A1). Polycyclic Aromatic Hydrocarbons 134-173 endogenous retrovirus group K member 21, envelope Homo sapiens 84-90 31628065-5 2019 RESULTS: We observed an increased expression of oxidative stress response protein NRF2, upon chronic exposure of primary keratinocytes to DPE/ its vapor which includes volatile components such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 196-228 NFE2 like bZIP transcription factor 2 Homo sapiens 82-86 31401431-0 2019 Polycyclic aromatic hydrocarbons in tree barks, gaseous and particulate phase samples collected near an industrial complex in Sao Paulo (Brazil). Polycyclic Aromatic Hydrocarbons 0-32 solute carrier family 4 member 1 (Diego blood group) Homo sapiens 126-129 31795255-4 2019 One transcription factor that is expressed in all cutaneous cells and activated by various environmental stressors, including dioxins, polycyclic aromatic hydrocarbons, and ultraviolet radiation, is the aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 135-167 aryl hydrocarbon receptor Homo sapiens 203-228 31795255-4 2019 One transcription factor that is expressed in all cutaneous cells and activated by various environmental stressors, including dioxins, polycyclic aromatic hydrocarbons, and ultraviolet radiation, is the aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 135-167 aryl hydrocarbon receptor Homo sapiens 230-233 31763181-0 2019 Toxicity of polycyclic aromatic hydrocarbons involves NOX2 activation. Polycyclic Aromatic Hydrocarbons 12-44 cytochrome b-245 beta chain Homo sapiens 54-58 31763181-8 2019 Finally, immunofluorescence microscopy was undertaken to examine the role of NOX2 due to PAHs toxicity. Polycyclic Aromatic Hydrocarbons 89-93 cytochrome b-245 beta chain Homo sapiens 77-81 31763181-10 2019 These data suggest that the mixture of PAHs is more toxic and perturbing to DNA synthesis than BaP alone in cultured cells, and the toxicity is accompanied by NOX2 activation. Polycyclic Aromatic Hydrocarbons 39-43 prohibitin 2 Homo sapiens 95-98 31763181-10 2019 These data suggest that the mixture of PAHs is more toxic and perturbing to DNA synthesis than BaP alone in cultured cells, and the toxicity is accompanied by NOX2 activation. Polycyclic Aromatic Hydrocarbons 39-43 cytochrome b-245 beta chain Homo sapiens 159-163 31729877-3 2019 Cage 1 selectively encapsulated coronene from among a mixture of eight different types of PAHs in nitromethane, bringing it into a new nitromethane phase by transiting through an intermediate water phase. Polycyclic Aromatic Hydrocarbons 90-94 cancer antigen 1 Homo sapiens 0-6 31628065-5 2019 RESULTS: We observed an increased expression of oxidative stress response protein NRF2, upon chronic exposure of primary keratinocytes to DPE/ its vapor which includes volatile components such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 230-234 NFE2 like bZIP transcription factor 2 Homo sapiens 82-86 31357365-6 2019 The limit of detection (LOD) for PAHs and nitro-PAHs ranged from 0.8 ng L-1 (phenanthrene) to 1.5 ng L-1 (indene [1,2,3-cd]pyrene) and from 300 ng L-1 (2-nitrofluorene) to 500 ng L-1 (2-nitrobiphenyl), respectively. Polycyclic Aromatic Hydrocarbons 33-37 immunoglobulin kappa variable 1-16 Homo sapiens 72-75 31357365-6 2019 The limit of detection (LOD) for PAHs and nitro-PAHs ranged from 0.8 ng L-1 (phenanthrene) to 1.5 ng L-1 (indene [1,2,3-cd]pyrene) and from 300 ng L-1 (2-nitrofluorene) to 500 ng L-1 (2-nitrobiphenyl), respectively. Polycyclic Aromatic Hydrocarbons 33-37 immunoglobulin kappa variable 1-16 Homo sapiens 101-104 31357365-6 2019 The limit of detection (LOD) for PAHs and nitro-PAHs ranged from 0.8 ng L-1 (phenanthrene) to 1.5 ng L-1 (indene [1,2,3-cd]pyrene) and from 300 ng L-1 (2-nitrofluorene) to 500 ng L-1 (2-nitrobiphenyl), respectively. Polycyclic Aromatic Hydrocarbons 33-37 immunoglobulin kappa variable 1-16 Homo sapiens 101-104 31357365-6 2019 The limit of detection (LOD) for PAHs and nitro-PAHs ranged from 0.8 ng L-1 (phenanthrene) to 1.5 ng L-1 (indene [1,2,3-cd]pyrene) and from 300 ng L-1 (2-nitrofluorene) to 500 ng L-1 (2-nitrobiphenyl), respectively. Polycyclic Aromatic Hydrocarbons 33-37 immunoglobulin kappa variable 1-16 Homo sapiens 101-104 31195173-1 2019 Polycyclic aromatic hydrocarbons containing at least 24 carbon atoms (>=C24-PAH) are often associated with pyrogenic processes such as combustion of fuel, wood or coal, and occur in the environment in diesel particulate matter, black carbon and coal tar. Polycyclic Aromatic Hydrocarbons 0-32 phenylalanine hydroxylase Homo sapiens 79-82 31369996-0 2019 Filaggrin variations are associated with PAH metabolites in urine and DNA alterations in blood. Polycyclic Aromatic Hydrocarbons 41-44 filaggrin Homo sapiens 0-9 31369996-3 2019 The aim of this study was to investigate, in chimney sweeps with occupational exposure to polycyclic aromatic hydrocarbons (PAH) from soot, the influence of variation in FLG on internal PAH dose and DNA alterations, including epigenetic, previously linked to cancer and cardiovascular disease. Polycyclic Aromatic Hydrocarbons 90-122 filaggrin Homo sapiens 170-173 31369996-3 2019 The aim of this study was to investigate, in chimney sweeps with occupational exposure to polycyclic aromatic hydrocarbons (PAH) from soot, the influence of variation in FLG on internal PAH dose and DNA alterations, including epigenetic, previously linked to cancer and cardiovascular disease. Polycyclic Aromatic Hydrocarbons 186-189 filaggrin Homo sapiens 170-173 31369996-12 2019 Our results suggest that FLG variations may influence the dose of PAH in highly exposed workers, possibly via dermal uptake. Polycyclic Aromatic Hydrocarbons 66-69 filaggrin Homo sapiens 25-28 31254350-2 2019 The present study was designed to investigate whether maternal NAT2 genetic polymorphisms are associated with fetal susceptibility to congenital heart diseases (CHDs) and to assess whether the risk is modified by polycyclic aromatic hydrocarbons (PAHs) exposure. Polycyclic Aromatic Hydrocarbons 247-251 N-acetyltransferase 2 Homo sapiens 63-67 31301797-7 2019 The M-PCTP also demonstrated good extraction capabilities for other different kinds of organic compounds including chlorophenols and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 133-165 phosphatidylcholine transfer protein Homo sapiens 6-10 31185349-0 2019 FLT1 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation. Polycyclic Aromatic Hydrocarbons 37-69 fms related receptor tyrosine kinase 1 Homo sapiens 0-4 31220655-4 2019 In the watershed, PAH concentrations in wet season (48.6 +- 18.2 ng L-1) were significantly lower than in dry season (90.3 +- 18.5 ng L-1). Polycyclic Aromatic Hydrocarbons 18-21 immunoglobulin kappa variable 1-16 Homo sapiens 68-71 31220655-4 2019 In the watershed, PAH concentrations in wet season (48.6 +- 18.2 ng L-1) were significantly lower than in dry season (90.3 +- 18.5 ng L-1). Polycyclic Aromatic Hydrocarbons 18-21 immunoglobulin kappa variable 1-16 Homo sapiens 134-137 31220655-5 2019 In contrast, estuarine PAH concentrations in wet season (67.1 +- 24.6 ng L-1) were significantly higher than in dry season (27.4 +- 10.6 ng L-1) (p < 0.0001). Polycyclic Aromatic Hydrocarbons 23-26 immunoglobulin kappa variable 1-16 Homo sapiens 73-76 31386991-9 2019 Smaller by-products like (Z)-prop-1-ene-1,2,3-triol (m/z = 91) and (E)-3-hydroxyacrylaldehyde (m/z = 71) identified in GC-MS, evidently braced e- excitement from encapsulated nanocatalyst followed by OH (active species) based oxidation of PAHs. Polycyclic Aromatic Hydrocarbons 239-243 PROP paired-like homeobox 1 Homo sapiens 29-35 31419470-0 2019 In vitro prenatal developmental toxicity induced by some petroleum substances is mediated by their 3- to 7-ring PAH constituent with a potential role for the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 112-115 aryl-hydrocarbon receptor Mus musculus 158-183 31419470-0 2019 In vitro prenatal developmental toxicity induced by some petroleum substances is mediated by their 3- to 7-ring PAH constituent with a potential role for the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 112-115 aryl-hydrocarbon receptor Mus musculus 185-188 29572542-3 2019 We showed that AhR ligands, including an environmental polycyclic aromatic hydrocarbon (PAH), induced S1P generation, and inhibited S1P lyase (S1PL) activity in resting cells, antigen/IgE-activated mast cells, and mouse lungs exposed to the AhR ligand alone or in combination with antigen challenge. Polycyclic Aromatic Hydrocarbons 55-86 aryl-hydrocarbon receptor Mus musculus 15-18 29572542-3 2019 We showed that AhR ligands, including an environmental polycyclic aromatic hydrocarbon (PAH), induced S1P generation, and inhibited S1P lyase (S1PL) activity in resting cells, antigen/IgE-activated mast cells, and mouse lungs exposed to the AhR ligand alone or in combination with antigen challenge. Polycyclic Aromatic Hydrocarbons 55-86 sphingosine-1-phosphate receptor 1 Mus musculus 102-105 29572542-3 2019 We showed that AhR ligands, including an environmental polycyclic aromatic hydrocarbon (PAH), induced S1P generation, and inhibited S1P lyase (S1PL) activity in resting cells, antigen/IgE-activated mast cells, and mouse lungs exposed to the AhR ligand alone or in combination with antigen challenge. Polycyclic Aromatic Hydrocarbons 55-86 sphingosine phosphate lyase 1 Mus musculus 132-141 29572542-3 2019 We showed that AhR ligands, including an environmental polycyclic aromatic hydrocarbon (PAH), induced S1P generation, and inhibited S1P lyase (S1PL) activity in resting cells, antigen/IgE-activated mast cells, and mouse lungs exposed to the AhR ligand alone or in combination with antigen challenge. Polycyclic Aromatic Hydrocarbons 55-86 sphingosine phosphate lyase 1 Mus musculus 143-147 29572542-3 2019 We showed that AhR ligands, including an environmental polycyclic aromatic hydrocarbon (PAH), induced S1P generation, and inhibited S1P lyase (S1PL) activity in resting cells, antigen/IgE-activated mast cells, and mouse lungs exposed to the AhR ligand alone or in combination with antigen challenge. Polycyclic Aromatic Hydrocarbons 55-86 aryl-hydrocarbon receptor Mus musculus 241-244 29572542-3 2019 We showed that AhR ligands, including an environmental polycyclic aromatic hydrocarbon (PAH), induced S1P generation, and inhibited S1P lyase (S1PL) activity in resting cells, antigen/IgE-activated mast cells, and mouse lungs exposed to the AhR ligand alone or in combination with antigen challenge. Polycyclic Aromatic Hydrocarbons 88-91 aryl-hydrocarbon receptor Mus musculus 15-18 29572542-3 2019 We showed that AhR ligands, including an environmental polycyclic aromatic hydrocarbon (PAH), induced S1P generation, and inhibited S1P lyase (S1PL) activity in resting cells, antigen/IgE-activated mast cells, and mouse lungs exposed to the AhR ligand alone or in combination with antigen challenge. Polycyclic Aromatic Hydrocarbons 88-91 sphingosine-1-phosphate receptor 1 Mus musculus 102-105 29572542-3 2019 We showed that AhR ligands, including an environmental polycyclic aromatic hydrocarbon (PAH), induced S1P generation, and inhibited S1P lyase (S1PL) activity in resting cells, antigen/IgE-activated mast cells, and mouse lungs exposed to the AhR ligand alone or in combination with antigen challenge. Polycyclic Aromatic Hydrocarbons 88-91 sphingosine phosphate lyase 1 Mus musculus 132-141 29572542-3 2019 We showed that AhR ligands, including an environmental polycyclic aromatic hydrocarbon (PAH), induced S1P generation, and inhibited S1P lyase (S1PL) activity in resting cells, antigen/IgE-activated mast cells, and mouse lungs exposed to the AhR ligand alone or in combination with antigen challenge. Polycyclic Aromatic Hydrocarbons 88-91 sphingosine phosphate lyase 1 Mus musculus 143-147 29572542-3 2019 We showed that AhR ligands, including an environmental polycyclic aromatic hydrocarbon (PAH), induced S1P generation, and inhibited S1P lyase (S1PL) activity in resting cells, antigen/IgE-activated mast cells, and mouse lungs exposed to the AhR ligand alone or in combination with antigen challenge. Polycyclic Aromatic Hydrocarbons 88-91 aryl-hydrocarbon receptor Mus musculus 241-244 31102418-2 2019 Sulfotransferases (SULTs) are involved in the metabolism of alkylated polycyclic aromatic hydrocarbons such as 1-hydroxymethylpyrene (1-HMP), which is a known substrate for SULT1A1. Polycyclic Aromatic Hydrocarbons 70-102 sulfotransferase family 1A member 1 Homo sapiens 173-180 30694518-1 2019 Glutathione-S transferases (GSTs) are xenobiotic-conjugation enzymes involved in the detoxification process of heterocyclic aromatic amines and polycyclic aromatic hydrocarbons, widely recognized risk factors of colorectal cancer (CRC) development. Polycyclic Aromatic Hydrocarbons 144-176 glutathione S-transferase alpha 1 Homo sapiens 28-32 30848509-4 2019 The sediment samples were used for the selection of two microbial consortia (indicated as PSO and PSM) with high biodegradation capacity for crude oil (~95%) and PAHs (~63%) respectively. Polycyclic Aromatic Hydrocarbons 162-166 pipecolic acid and sarcosine oxidase Homo sapiens 90-93 30848509-4 2019 The sediment samples were used for the selection of two microbial consortia (indicated as PSO and PSM) with high biodegradation capacity for crude oil (~95%) and PAHs (~63%) respectively. Polycyclic Aromatic Hydrocarbons 162-166 folate hydrolase 1B (pseudogene) Homo sapiens 98-101 31439044-7 2019 This is in accordance with a role of PAHs, as they seem to be the major chemical group on combustion particles, which bind AhR and/or is metabolically activated by CYP-enzymes. Polycyclic Aromatic Hydrocarbons 37-41 aryl hydrocarbon receptor Homo sapiens 123-126 31071665-8 2019 Based on a detailed chemical analysis of both extracts and their polar fractions, we identified several oxygenated PAH derivatives, that were present at relatively high levels in the analyzed DEP standards, including 3-nitrobenzanthrone (3-NBA), anthracene-9,10-dione, phenanthrene-9,10-dione, 9H-fluoren-9-one or benzo[a]anthracene-7,12-dione, to activate TRalpha activity. Polycyclic Aromatic Hydrocarbons 115-118 T cell receptor alpha locus Homo sapiens 357-364 31208719-0 2019 Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB). Polycyclic Aromatic Hydrocarbons 39-71 phenylalanine hydroxylase Homo sapiens 73-76 31208719-9 2019 In summary, this is the first report showing an association between PAH levels, DNA adducts, and modulation of endogenous metabolic pathways with PTBs in subjects residing near Superfund sites, and further studies could lead to novel strategies in the understanding of the mechanisms by which PAHs contribute to PTBs in women. Polycyclic Aromatic Hydrocarbons 293-297 phenylalanine hydroxylase Homo sapiens 68-71 31406187-3 2019 First, we found that vitamin E in the human prostate epithelial RWPE-1 cell line has the remarkable ability to upregulate the expression of various phase-I activating cytochrome P450 (CYP) enzymes, including activators of polycyclic aromatic hydrocarbons (PAHs), giving rise to supraphysiological levels of reactive oxygen species. Polycyclic Aromatic Hydrocarbons 222-254 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 184-187 31406187-3 2019 First, we found that vitamin E in the human prostate epithelial RWPE-1 cell line has the remarkable ability to upregulate the expression of various phase-I activating cytochrome P450 (CYP) enzymes, including activators of polycyclic aromatic hydrocarbons (PAHs), giving rise to supraphysiological levels of reactive oxygen species. Polycyclic Aromatic Hydrocarbons 256-260 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 184-187 31394804-8 2019 Several diagnostic PAH ratios indicated that the main sources of PAHs in Shenyang in the warm and cold seasons were not only coal burning but also vehicle emission. Polycyclic Aromatic Hydrocarbons 65-69 phenylalanine hydroxylase Homo sapiens 19-22 31086989-1 2019 Environmental pollutants including halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons, including benzo[a]pyrene, exert their deleterious effects through the activation of the aryl hydrocarbon receptor (AHR) and by the resulting transcription of genes not yet fully identified. Polycyclic Aromatic Hydrocarbons 73-105 aryl-hydrocarbon receptor Mus musculus 195-220 31086989-1 2019 Environmental pollutants including halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons, including benzo[a]pyrene, exert their deleterious effects through the activation of the aryl hydrocarbon receptor (AHR) and by the resulting transcription of genes not yet fully identified. Polycyclic Aromatic Hydrocarbons 73-105 aryl-hydrocarbon receptor Mus musculus 222-225 31368503-0 2019 Polycyclic aromatic hydrocarbons can trigger hepatocyte release of extracellular vesicles by various mechanisms of action depending on their affinity for the aryl hydrocarbon receptor. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Rattus norvegicus 158-183 31365547-11 2019 PAH exposure was associated with changes in T cells, monocytes and T memory (Tmem) cells and with changes in Th, Th1, Th2 and Th17 subsets all of which were non-monotonic (dose dependent). Polycyclic Aromatic Hydrocarbons 0-3 negative elongation factor complex member C/D Homo sapiens 113-116 31368503-5 2019 Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR). Polycyclic Aromatic Hydrocarbons 6-10 aryl hydrocarbon receptor Rattus norvegicus 85-110 31368503-5 2019 Three PAHs were selected, based on their presence in food and their affinity for the aryl hydrocarbon receptor (AhR): benzo(a)pyrene (BP), dibenzo(a,h)anthracene (DBA), and pyrene (PYR). Polycyclic Aromatic Hydrocarbons 6-10 aryl hydrocarbon receptor Rattus norvegicus 112-115 31358014-0 2019 CYP1A1 methylation mediates the effect of smoking and occupational polycyclic aromatic hydrocarbons co-exposure on oxidative DNA damage among Chinese coke-oven workers. Polycyclic Aromatic Hydrocarbons 67-99 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 31358014-3 2019 This study was undertaken to evaluate whether Cytochrome P4501A1 (CYP1A1) methylation can mediate the co-exposure effect between smoking and occupational polycyclic aromatic hydrocarbons (PAH) in development of oxidative DNA damage. Polycyclic Aromatic Hydrocarbons 154-186 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 46-64 31358014-3 2019 This study was undertaken to evaluate whether Cytochrome P4501A1 (CYP1A1) methylation can mediate the co-exposure effect between smoking and occupational polycyclic aromatic hydrocarbons (PAH) in development of oxidative DNA damage. Polycyclic Aromatic Hydrocarbons 154-186 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 66-72 31358014-3 2019 This study was undertaken to evaluate whether Cytochrome P4501A1 (CYP1A1) methylation can mediate the co-exposure effect between smoking and occupational polycyclic aromatic hydrocarbons (PAH) in development of oxidative DNA damage. Polycyclic Aromatic Hydrocarbons 188-191 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 46-64 31358014-3 2019 This study was undertaken to evaluate whether Cytochrome P4501A1 (CYP1A1) methylation can mediate the co-exposure effect between smoking and occupational polycyclic aromatic hydrocarbons (PAH) in development of oxidative DNA damage. Polycyclic Aromatic Hydrocarbons 188-191 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 66-72 31358014-11 2019 CONCLUSIONS: Our findings suggested that the co-exposure effect of smoking and occupational PAH could increase the risk of oxidative DNA damage by a mechanism partly involving CYP1A1 hypomethylation. Polycyclic Aromatic Hydrocarbons 92-95 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 176-182 31264416-5 2019 Coefficients in the model were determined using a data set including the organic carbon-water partition coefficient (KOC) of four polycyclic aromatic hydrocarbons (PAHs) sorption to 10 NOM samples collected from surface waters. Polycyclic Aromatic Hydrocarbons 130-162 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 117-120 31051230-3 2019 The present work aimed to investigate the role of CYP1A1 gene in PAH-mediated growth and tumor development in vitro and using an in vivo animal model. Polycyclic Aromatic Hydrocarbons 65-68 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 50-56 31051230-5 2019 Treatment of PAH-induced human alveolar adenocarcinoma cell line with cationic liposomes carrying CYP1A1 siRNA resulted in down regulation of CYP1A1 mRNA, protein as well as its enzymatic activity, triggering apoptosis and inhibiting multicellular tumor spheroids formation in vitro. Polycyclic Aromatic Hydrocarbons 13-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 98-104 31051230-5 2019 Treatment of PAH-induced human alveolar adenocarcinoma cell line with cationic liposomes carrying CYP1A1 siRNA resulted in down regulation of CYP1A1 mRNA, protein as well as its enzymatic activity, triggering apoptosis and inhibiting multicellular tumor spheroids formation in vitro. Polycyclic Aromatic Hydrocarbons 13-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 142-148 31317342-9 2019 The method has a linear response in the 0.1 to 200 mug L-1 PAH concentration range. Polycyclic Aromatic Hydrocarbons 59-62 L1 cell adhesion molecule Homo sapiens 55-58 31854704-4 2019 The results showed that:(1) in the dry season, eight kinds of PAHs were detected, the concentrations of which ranged from 1455.38 ng L-1to 2538.84 ng L-1. Polycyclic Aromatic Hydrocarbons 62-66 immunoglobulin kappa variable 1-16 Homo sapiens 133-136 31854704-5 2019 In the plentiful season, 12 kinds of PAHs were detected, the concentrations of which ranged from 818.69 ng L-1 to 1582.14 ng L-1. Polycyclic Aromatic Hydrocarbons 37-41 immunoglobulin kappa variable 1-16 Homo sapiens 107-110 31854704-5 2019 In the plentiful season, 12 kinds of PAHs were detected, the concentrations of which ranged from 818.69 ng L-1 to 1582.14 ng L-1. Polycyclic Aromatic Hydrocarbons 37-41 immunoglobulin kappa variable 1-16 Homo sapiens 125-128 30753342-6 2019 Concentrations of the peptidase kallikrein 13 (KLK13) showed significant positive associations with urinary concentrations of the PAH metabolites 3-hydroxybenzo[a]pyrene (3-OH-BaP) [B, 95% confidence interval (CI): 0.042, 0.008-0.076] and 3-hydroxybenzo[a]anthracene (3-OH-BaA) (B, 95% CI: 0.068, 0.002-0.134). Polycyclic Aromatic Hydrocarbons 130-133 kallikrein related peptidase 13 Homo sapiens 32-45 30753342-6 2019 Concentrations of the peptidase kallikrein 13 (KLK13) showed significant positive associations with urinary concentrations of the PAH metabolites 3-hydroxybenzo[a]pyrene (3-OH-BaP) [B, 95% confidence interval (CI): 0.042, 0.008-0.076] and 3-hydroxybenzo[a]anthracene (3-OH-BaA) (B, 95% CI: 0.068, 0.002-0.134). Polycyclic Aromatic Hydrocarbons 130-133 kallikrein related peptidase 13 Homo sapiens 47-52 30772690-6 2019 Higher manganese peroxidase in composting treatments indicated increased activity of ligninolytic PAH-degrading microorganisms. Polycyclic Aromatic Hydrocarbons 98-101 Peroxidase Drosophila melanogaster 17-27 31261819-4 2019 The presence of PAHs, such as BbF, BkF, InP, and BgP, that are known pollutants of concern, suggests certain ecological risks. Polycyclic Aromatic Hydrocarbons 16-20 CEA cell adhesion molecule 1 Homo sapiens 49-52 31228248-6 2019 Of the 25 proteins, follistatin (FS), pro-interleukin-16 (IL-16), and heat shock protein beta-1 (HSP 27) showed positive associations with the monohydroxylated metabolites of PAH in a dose-response manner (P<0.05). Polycyclic Aromatic Hydrocarbons 175-178 interleukin 16 Homo sapiens 38-56 31228248-6 2019 Of the 25 proteins, follistatin (FS), pro-interleukin-16 (IL-16), and heat shock protein beta-1 (HSP 27) showed positive associations with the monohydroxylated metabolites of PAH in a dose-response manner (P<0.05). Polycyclic Aromatic Hydrocarbons 175-178 interleukin 16 Homo sapiens 58-63 31228248-6 2019 Of the 25 proteins, follistatin (FS), pro-interleukin-16 (IL-16), and heat shock protein beta-1 (HSP 27) showed positive associations with the monohydroxylated metabolites of PAH in a dose-response manner (P<0.05). Polycyclic Aromatic Hydrocarbons 175-178 heat shock protein family B (small) member 1 Homo sapiens 70-95 31228248-6 2019 Of the 25 proteins, follistatin (FS), pro-interleukin-16 (IL-16), and heat shock protein beta-1 (HSP 27) showed positive associations with the monohydroxylated metabolites of PAH in a dose-response manner (P<0.05). Polycyclic Aromatic Hydrocarbons 175-178 heat shock protein family B (small) member 1 Homo sapiens 97-103 30807913-2 2019 This study aimed to quantify the associations of 8-oxoguanine DNA glycosylase (OGG1) methylation with urinary PAHs metabolites, DNA damage and cell cycle arrest, and further to assess the role of OGG1 methylation in mediating the association of urinary PAHs metabolites with DNA damage and cell cycle arrest. Polycyclic Aromatic Hydrocarbons 110-114 8-oxoguanine DNA glycosylase Homo sapiens 49-77 30807913-2 2019 This study aimed to quantify the associations of 8-oxoguanine DNA glycosylase (OGG1) methylation with urinary PAHs metabolites, DNA damage and cell cycle arrest, and further to assess the role of OGG1 methylation in mediating the association of urinary PAHs metabolites with DNA damage and cell cycle arrest. Polycyclic Aromatic Hydrocarbons 110-114 8-oxoguanine DNA glycosylase Homo sapiens 79-83 30807913-2 2019 This study aimed to quantify the associations of 8-oxoguanine DNA glycosylase (OGG1) methylation with urinary PAHs metabolites, DNA damage and cell cycle arrest, and further to assess the role of OGG1 methylation in mediating the association of urinary PAHs metabolites with DNA damage and cell cycle arrest. Polycyclic Aromatic Hydrocarbons 253-257 8-oxoguanine DNA glycosylase Homo sapiens 79-83 31152234-2 2019 Detection sensitivity is improved by modifying gold nanoparticles (AuNPs) with 4-mercaptophenylboronic acid (4-MPBA) conjugated to beta-cyclodextrin (beta-CD) as a new method for ratiometric determination of PAHs in solution. Polycyclic Aromatic Hydrocarbons 208-212 ACD shelterin complex subunit and telomerase recruitment factor Homo sapiens 150-157 31095595-12 2019 Dose response curves were non-monotonic for PAH-DNA adduct exposures and suggested that cytokine secretion of IFNg, IL-1b, IL-2, IL-10 and IL17A followed a complex pattern. Polycyclic Aromatic Hydrocarbons 44-47 interferon gamma Homo sapiens 110-114 31348278-0 2019 The effect on congenital heart diseases of maternal EPHX1 polymorphisms modified by polycyclic aromatic hydrocarbons exposure. Polycyclic Aromatic Hydrocarbons 84-116 epoxide hydrolase 1 Homo sapiens 52-57 31348278-6 2019 A possible modifying effect of PAHs exposure on genetic polymorphisms of EPHX1 was found in susceptibility to CHDs, though no multiplicative-scale interactions between maternal exposure to PAHs and polymorphisms of EPHX1 gene were seento affect the risk of CHDs.The role of EPHX1 gene polymorphisms for CHDs need to be further evaluated, in particularly by interacting with PAHs exposure. Polycyclic Aromatic Hydrocarbons 31-35 epoxide hydrolase 1 Homo sapiens 73-78 31348278-6 2019 A possible modifying effect of PAHs exposure on genetic polymorphisms of EPHX1 was found in susceptibility to CHDs, though no multiplicative-scale interactions between maternal exposure to PAHs and polymorphisms of EPHX1 gene were seento affect the risk of CHDs.The role of EPHX1 gene polymorphisms for CHDs need to be further evaluated, in particularly by interacting with PAHs exposure. Polycyclic Aromatic Hydrocarbons 31-35 epoxide hydrolase 1 Homo sapiens 215-220 31348278-6 2019 A possible modifying effect of PAHs exposure on genetic polymorphisms of EPHX1 was found in susceptibility to CHDs, though no multiplicative-scale interactions between maternal exposure to PAHs and polymorphisms of EPHX1 gene were seento affect the risk of CHDs.The role of EPHX1 gene polymorphisms for CHDs need to be further evaluated, in particularly by interacting with PAHs exposure. Polycyclic Aromatic Hydrocarbons 31-35 epoxide hydrolase 1 Homo sapiens 215-220 31228248-6 2019 Of the 25 proteins, follistatin (FS), pro-interleukin-16 (IL-16), and heat shock protein beta-1 (HSP 27) showed positive associations with the monohydroxylated metabolites of PAH in a dose-response manner (P<0.05). Polycyclic Aromatic Hydrocarbons 175-178 follistatin Homo sapiens 20-31 30904656-7 2019 Children with particle-bound PAH exposures have a relatively high health risk of aryl hydrocarbon receptor (AhR)-mediated adverse outcomes than adults, in particular in the winter period, while the activations of Nrf2 and p53 pathways are insignificant. Polycyclic Aromatic Hydrocarbons 29-32 aryl hydrocarbon receptor Homo sapiens 81-106 30904656-7 2019 Children with particle-bound PAH exposures have a relatively high health risk of aryl hydrocarbon receptor (AhR)-mediated adverse outcomes than adults, in particular in the winter period, while the activations of Nrf2 and p53 pathways are insignificant. Polycyclic Aromatic Hydrocarbons 29-32 aryl hydrocarbon receptor Homo sapiens 108-111 30904656-7 2019 Children with particle-bound PAH exposures have a relatively high health risk of aryl hydrocarbon receptor (AhR)-mediated adverse outcomes than adults, in particular in the winter period, while the activations of Nrf2 and p53 pathways are insignificant. Polycyclic Aromatic Hydrocarbons 29-32 NFE2 like bZIP transcription factor 2 Homo sapiens 213-217 30904656-7 2019 Children with particle-bound PAH exposures have a relatively high health risk of aryl hydrocarbon receptor (AhR)-mediated adverse outcomes than adults, in particular in the winter period, while the activations of Nrf2 and p53 pathways are insignificant. Polycyclic Aromatic Hydrocarbons 29-32 tumor protein p53 Homo sapiens 222-225 30418489-5 2019 We show that treatment of cells with exogenous TGFbeta leads to enhanced repair of DNA damage formed by polycyclic aromatic hydrocarbons and ultraviolet-C radiation; similarly, cells with constitutively activated endogenous TGFbeta signaling show comparable responses. Polycyclic Aromatic Hydrocarbons 104-136 transforming growth factor alpha Homo sapiens 47-54 31142653-1 2019 Benzo[a]pyrene (BaP), a key polycyclic aromatic hydrocarbon (PAH) often associated with soot particles coated by organic compounds, is a known carcinogen and mutagen. Polycyclic Aromatic Hydrocarbons 28-59 prohibitin 2 Homo sapiens 16-19 31142653-1 2019 Benzo[a]pyrene (BaP), a key polycyclic aromatic hydrocarbon (PAH) often associated with soot particles coated by organic compounds, is a known carcinogen and mutagen. Polycyclic Aromatic Hydrocarbons 61-64 prohibitin 2 Homo sapiens 16-19 31142653-4 2019 Kinetic multilayer modeling demonstrates that the slow decay of BaP over long times can be simulated if there is slow diffusion of BaP from the film interior to the surface, resolving long-standing unresolved observations of incomplete PAH decay upon prolonged ozone exposure. Polycyclic Aromatic Hydrocarbons 236-239 prohibitin 2 Homo sapiens 64-67 31142653-4 2019 Kinetic multilayer modeling demonstrates that the slow decay of BaP over long times can be simulated if there is slow diffusion of BaP from the film interior to the surface, resolving long-standing unresolved observations of incomplete PAH decay upon prolonged ozone exposure. Polycyclic Aromatic Hydrocarbons 236-239 prohibitin 2 Homo sapiens 131-134 30851530-3 2019 In this study, we developed a new method for the detection of particle-bound PAHs, nitro-PAHs and oxy-PAHs using direct infusion into an atmospheric pressure photoionisation high-resolution mass spectrometer (APPI-HRMS). Polycyclic Aromatic Hydrocarbons 77-81 amyloid beta precursor protein Homo sapiens 209-213 30955163-4 2019 Moreover, CDP typically consist of carbon cores with a complex mixture of organic chemicals such as polycyclic aromatic hydrocarbons (PAHs) adhered. Polycyclic Aromatic Hydrocarbons 100-132 cut like homeobox 1 Homo sapiens 10-13 30955163-4 2019 Moreover, CDP typically consist of carbon cores with a complex mixture of organic chemicals such as polycyclic aromatic hydrocarbons (PAHs) adhered. Polycyclic Aromatic Hydrocarbons 134-138 cut like homeobox 1 Homo sapiens 10-13 30955163-8 2019 CDP, extractable organic material from CDP (CDP-EOM), and PAHs may increase intracellular calcium levels by interacting with calcium channels like transient receptor potential (TRP) channels, and receptors such as G protein-coupled receptors (GPCR; e.g., beta-adrenergic receptors [betaAR] and protease-activated receptor 2 [PAR-2]) and the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 58-62 F2R like trypsin receptor 1 Homo sapiens 294-323 30955163-8 2019 CDP, extractable organic material from CDP (CDP-EOM), and PAHs may increase intracellular calcium levels by interacting with calcium channels like transient receptor potential (TRP) channels, and receptors such as G protein-coupled receptors (GPCR; e.g., beta-adrenergic receptors [betaAR] and protease-activated receptor 2 [PAR-2]) and the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 58-62 F2R like trypsin receptor 1 Homo sapiens 325-330 30955163-8 2019 CDP, extractable organic material from CDP (CDP-EOM), and PAHs may increase intracellular calcium levels by interacting with calcium channels like transient receptor potential (TRP) channels, and receptors such as G protein-coupled receptors (GPCR; e.g., beta-adrenergic receptors [betaAR] and protease-activated receptor 2 [PAR-2]) and the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 58-62 aryl hydrocarbon receptor Homo sapiens 341-366 30955163-8 2019 CDP, extractable organic material from CDP (CDP-EOM), and PAHs may increase intracellular calcium levels by interacting with calcium channels like transient receptor potential (TRP) channels, and receptors such as G protein-coupled receptors (GPCR; e.g., beta-adrenergic receptors [betaAR] and protease-activated receptor 2 [PAR-2]) and the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 58-62 aryl hydrocarbon receptor Homo sapiens 368-371 31055747-7 2019 In addition, the transported distance from local PAH emission sources was found to greatly affect the composition and concentration of PAHs in sites YC1 and YC2. Polycyclic Aromatic Hydrocarbons 49-52 RNA binding motif single stranded interacting protein 1 Homo sapiens 149-152 31055747-7 2019 In addition, the transported distance from local PAH emission sources was found to greatly affect the composition and concentration of PAHs in sites YC1 and YC2. Polycyclic Aromatic Hydrocarbons 135-139 RNA binding motif single stranded interacting protein 1 Homo sapiens 149-152 30904456-4 2019 We suggest AhR-mediated activation of PAHs metabolism in JEG-3 cells, and AhR interaction with NFkappaB and AhR cross-talk with ERalpha causing inhibition of detoxification in BeWo cells. Polycyclic Aromatic Hydrocarbons 38-42 aryl hydrocarbon receptor Homo sapiens 11-14 31064411-0 2019 Casp8 hypomethylation and neural tube defects in association with polycyclic aromatic hydrocarbon exposure. Polycyclic Aromatic Hydrocarbons 66-97 caspase 8 Mus musculus 0-5 31064411-3 2019 However, the role of DNA methylation aberration of apoptotic initiator CASP8 (caspase-8, apoptosis-related cysteine peptidase) in the formation of NTDs in association with PAH exposure is not known. Polycyclic Aromatic Hydrocarbons 172-175 caspase 8 Mus musculus 71-76 31064411-3 2019 However, the role of DNA methylation aberration of apoptotic initiator CASP8 (caspase-8, apoptosis-related cysteine peptidase) in the formation of NTDs in association with PAH exposure is not known. Polycyclic Aromatic Hydrocarbons 172-175 caspase 8 Mus musculus 78-87 31064411-7 2019 According to Pearson"s correlation, methylation levels of CASP8 were inversely correlated with PAH concentrations in maternal serum and with oxidative stress markers in fetal neural tissues (p < 0.05). Polycyclic Aromatic Hydrocarbons 95-98 caspase 8 Mus musculus 58-63 31070457-9 2019 While evidence for epigenetic regulation remains limited, polycyclic aromatic hydrocarbons (PAH) and nitrogen dioxide (NO2) exposures may alter methylation of breast tumorigenic genes (e.g., EPHB2, LONP1). Polycyclic Aromatic Hydrocarbons 58-90 EPH receptor B2 Homo sapiens 191-196 31070457-9 2019 While evidence for epigenetic regulation remains limited, polycyclic aromatic hydrocarbons (PAH) and nitrogen dioxide (NO2) exposures may alter methylation of breast tumorigenic genes (e.g., EPHB2, LONP1). Polycyclic Aromatic Hydrocarbons 58-90 lon peptidase 1, mitochondrial Homo sapiens 198-203 31070457-9 2019 While evidence for epigenetic regulation remains limited, polycyclic aromatic hydrocarbons (PAH) and nitrogen dioxide (NO2) exposures may alter methylation of breast tumorigenic genes (e.g., EPHB2, LONP1). Polycyclic Aromatic Hydrocarbons 92-95 EPH receptor B2 Homo sapiens 191-196 31070457-9 2019 While evidence for epigenetic regulation remains limited, polycyclic aromatic hydrocarbons (PAH) and nitrogen dioxide (NO2) exposures may alter methylation of breast tumorigenic genes (e.g., EPHB2, LONP1). Polycyclic Aromatic Hydrocarbons 92-95 lon peptidase 1, mitochondrial Homo sapiens 198-203 30850392-1 2019 UDP-glucuronosyltransferase (UGT) 2A1 is an important enzyme in the detoxification of polycyclic aromatic hydrocarbons found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 86-118 UDP glucuronosyltransferase family 2 member A1 complex locus Homo sapiens 0-37 31232332-2 2019 The PAH concentrations ranged from 48.0 to 607 ng L-1 with the mean value of 267 ng L-1 in dissolved phase and 198 to 935 ng L-1 with the mean value of 424 ng L-1 in particle-associated phase, and decreased following the order: Qinhuangdao (QHD) > Caofeidian (CFD) > Huanghuagang (HHG). Polycyclic Aromatic Hydrocarbons 4-7 immunoglobulin kappa variable 1-16 Homo sapiens 50-53 31232332-2 2019 The PAH concentrations ranged from 48.0 to 607 ng L-1 with the mean value of 267 ng L-1 in dissolved phase and 198 to 935 ng L-1 with the mean value of 424 ng L-1 in particle-associated phase, and decreased following the order: Qinhuangdao (QHD) > Caofeidian (CFD) > Huanghuagang (HHG). Polycyclic Aromatic Hydrocarbons 4-7 immunoglobulin kappa variable 1-16 Homo sapiens 84-87 31232332-2 2019 The PAH concentrations ranged from 48.0 to 607 ng L-1 with the mean value of 267 ng L-1 in dissolved phase and 198 to 935 ng L-1 with the mean value of 424 ng L-1 in particle-associated phase, and decreased following the order: Qinhuangdao (QHD) > Caofeidian (CFD) > Huanghuagang (HHG). Polycyclic Aromatic Hydrocarbons 4-7 immunoglobulin kappa variable 1-16 Homo sapiens 84-87 31232332-2 2019 The PAH concentrations ranged from 48.0 to 607 ng L-1 with the mean value of 267 ng L-1 in dissolved phase and 198 to 935 ng L-1 with the mean value of 424 ng L-1 in particle-associated phase, and decreased following the order: Qinhuangdao (QHD) > Caofeidian (CFD) > Huanghuagang (HHG). Polycyclic Aromatic Hydrocarbons 4-7 immunoglobulin kappa variable 1-16 Homo sapiens 84-87 30685680-4 2019 Most importantly, nine novel by-products including one chlorobenzoquinone, four phenyl benzoquinones, and four polycyclic aromatic hydrocarbons were formed during BP-1 chlorination. Polycyclic Aromatic Hydrocarbons 111-143 BP1 Homo sapiens 163-167 31060609-3 2019 Studies on the association between AHRR methylation at cg05575921 and sources of polycyclic aromatic hydrocarbon (PAH) other than smoking are limited. Polycyclic Aromatic Hydrocarbons 81-112 aryl hydrocarbon receptor repressor Homo sapiens 35-39 31060609-3 2019 Studies on the association between AHRR methylation at cg05575921 and sources of polycyclic aromatic hydrocarbon (PAH) other than smoking are limited. Polycyclic Aromatic Hydrocarbons 114-117 aryl hydrocarbon receptor repressor Homo sapiens 35-39 30690640-1 2019 Low molecular weight polycyclic aromatic hydrocarbons (LMW PAHs; < 206.3 g/mol) are under regulated environmental contaminants (eg, secondhand smoke) that lead to gap junction dysregulation, p38 MAPK activation, and increased mRNA production of inflammatory mediators, such as cytokines and cyclooxygenase (COX2), in lung epithelial cells. Polycyclic Aromatic Hydrocarbons 21-53 mitogen-activated protein kinase 14 Mus musculus 194-197 30690640-1 2019 Low molecular weight polycyclic aromatic hydrocarbons (LMW PAHs; < 206.3 g/mol) are under regulated environmental contaminants (eg, secondhand smoke) that lead to gap junction dysregulation, p38 MAPK activation, and increased mRNA production of inflammatory mediators, such as cytokines and cyclooxygenase (COX2), in lung epithelial cells. Polycyclic Aromatic Hydrocarbons 21-53 cytochrome c oxidase II, mitochondrial Mus musculus 310-314 30690640-4 2019 Cytosolic phospholipase A2 inhibition reversed PAH-induced phospho-p38 MAPK activation and gap junction dysregulation at 30 min. Polycyclic Aromatic Hydrocarbons 47-50 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 0-26 30690640-4 2019 Cytosolic phospholipase A2 inhibition reversed PAH-induced phospho-p38 MAPK activation and gap junction dysregulation at 30 min. Polycyclic Aromatic Hydrocarbons 47-50 mitogen-activated protein kinase 14 Mus musculus 67-70 30690640-6 2019 Targeted metabolomics showed several eicosanoids (eg, prostaglandin D2 (PGD2), PGE2alpha) were significantly increased at 4, 8, and 12 h following exposure to the binary PAH mixture and this effect was p38-dependent. Polycyclic Aromatic Hydrocarbons 170-173 prostaglandin D2 synthase (brain) Mus musculus 54-70 30690640-6 2019 Targeted metabolomics showed several eicosanoids (eg, prostaglandin D2 (PGD2), PGE2alpha) were significantly increased at 4, 8, and 12 h following exposure to the binary PAH mixture and this effect was p38-dependent. Polycyclic Aromatic Hydrocarbons 170-173 prostaglandin D2 synthase (brain) Mus musculus 72-76 30690640-6 2019 Targeted metabolomics showed several eicosanoids (eg, prostaglandin D2 (PGD2), PGE2alpha) were significantly increased at 4, 8, and 12 h following exposure to the binary PAH mixture and this effect was p38-dependent. Polycyclic Aromatic Hydrocarbons 170-173 mitogen-activated protein kinase 14 Mus musculus 202-205 31018556-5 2019 Parthenolide, a pan-inflammation inhibitor, reversed the PAH-induced inhibition of GJIC, the decreased CX43 expression, and the induction of KC and TNF. Polycyclic Aromatic Hydrocarbons 57-60 gap junction protein, alpha 1 Mus musculus 103-107 31018556-5 2019 Parthenolide, a pan-inflammation inhibitor, reversed the PAH-induced inhibition of GJIC, the decreased CX43 expression, and the induction of KC and TNF. Polycyclic Aromatic Hydrocarbons 57-60 tumor necrosis factor Mus musculus 148-151 31018556-6 2019 To further determine the direct role of a cytokine in regulating GJIC, recombinant TNF (rTNF) was used to inhibit GJIC and this response was further enhanced in the presence of the PAH mixture. Polycyclic Aromatic Hydrocarbons 181-184 tumor necrosis factor Mus musculus 83-86 30553920-7 2019 Our results indicate that the combined effect of pairwise PAHs of BaP with Benzo[b]fluoranthene (BbF) and Benz[a]anthracene (BaA) is synergistic on p53 pathway, and that the health risk of the such mixtures increases compared to that of the individual ones. Polycyclic Aromatic Hydrocarbons 58-62 prohibitin 2 Homo sapiens 66-69 30553920-7 2019 Our results indicate that the combined effect of pairwise PAHs of BaP with Benzo[b]fluoranthene (BbF) and Benz[a]anthracene (BaA) is synergistic on p53 pathway, and that the health risk of the such mixtures increases compared to that of the individual ones. Polycyclic Aromatic Hydrocarbons 58-62 tumor protein p53 Homo sapiens 148-151 30868178-7 2019 The following PAHs presented the highest concentrations: benzo(a)anthracene y benzo(k)fluoranthene 13.26 and 7.88 microg L-1 respectively. Polycyclic Aromatic Hydrocarbons 14-18 immunoglobulin kappa variable 1-16 Homo sapiens 121-124 31096425-11 2019 Genes that are implicated in the response to PAHs, PCBs, dioxins and furans (cyp1a, cyp1b1, ahr2) were significantly elevated in the 120 hpf larvae exposed to the B1 and B2 sediments. Polycyclic Aromatic Hydrocarbons 45-49 cytochrome P450, family 1, subfamily A Danio rerio 77-82 31096425-11 2019 Genes that are implicated in the response to PAHs, PCBs, dioxins and furans (cyp1a, cyp1b1, ahr2) were significantly elevated in the 120 hpf larvae exposed to the B1 and B2 sediments. Polycyclic Aromatic Hydrocarbons 45-49 cytochrome P450, family 1, subfamily B, polypeptide 1 Danio rerio 84-90 31096425-11 2019 Genes that are implicated in the response to PAHs, PCBs, dioxins and furans (cyp1a, cyp1b1, ahr2) were significantly elevated in the 120 hpf larvae exposed to the B1 and B2 sediments. Polycyclic Aromatic Hydrocarbons 45-49 aryl hydrocarbon receptor 2 Danio rerio 92-96 31237164-10 2019 HMOX1 and SOD1 were downregulated after both 24-hour PAH treatments. Polycyclic Aromatic Hydrocarbons 53-56 heme oxygenase 1 Homo sapiens 0-5 31237164-10 2019 HMOX1 and SOD1 were downregulated after both 24-hour PAH treatments. Polycyclic Aromatic Hydrocarbons 53-56 superoxide dismutase 1 Homo sapiens 10-14 30543962-0 2019 Synergistic effects of sulfur dioxide and polycyclic aromatic hydrocarbons on pulmonary pro-fibrosis via mir-30c-1-3p/ transforming growth factor beta type II receptor axis. Polycyclic Aromatic Hydrocarbons 42-74 microRNA 30c-1 Mus musculus 105-114 30557722-5 2019 After almost two years the first application of biochar, PAH concentrations were higher in soil B (56 ng g-1) and BB (153 ng g-1) in comparison to control soil (24 ng g-1). Polycyclic Aromatic Hydrocarbons 57-60 proline rich protein BstNI subfamily 3 Homo sapiens 105-116 30609505-8 2019 A one-unit increase in inhaled doses of PM2.5-bound PAHs or in urinary concentrations of OH-PAHs was corresponded to a maximum FeNO increase of 13.5% (95% CI: 5.4, 22.2) at lag2 day or of 6.8% (95% CI: 3.4, 10.2) at lag1 day. Polycyclic Aromatic Hydrocarbons 52-56 granulysin Homo sapiens 174-178 30609505-8 2019 A one-unit increase in inhaled doses of PM2.5-bound PAHs or in urinary concentrations of OH-PAHs was corresponded to a maximum FeNO increase of 13.5% (95% CI: 5.4, 22.2) at lag2 day or of 6.8% (95% CI: 3.4, 10.2) at lag1 day. Polycyclic Aromatic Hydrocarbons 52-56 ceramide synthase 1 Homo sapiens 217-221 30573465-1 2019 Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that activate the aryl hydrocarbon receptor, thereby triggering a range of biologic responses, exemplified by the induction of CYP1A1 PAHs can also regulate the expression of members of the CYP3A subfamily, with reports of mainly suppressive effects on mouse hepatic Cyp3a11 expression, but paradoxically both inductive and suppressive effects on human hepatic CYP3A4 expression. Polycyclic Aromatic Hydrocarbons 0-32 aryl-hydrocarbon receptor Mus musculus 87-112 30573465-1 2019 Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that activate the aryl hydrocarbon receptor, thereby triggering a range of biologic responses, exemplified by the induction of CYP1A1 PAHs can also regulate the expression of members of the CYP3A subfamily, with reports of mainly suppressive effects on mouse hepatic Cyp3a11 expression, but paradoxically both inductive and suppressive effects on human hepatic CYP3A4 expression. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 196-202 30573465-1 2019 Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that activate the aryl hydrocarbon receptor, thereby triggering a range of biologic responses, exemplified by the induction of CYP1A1 PAHs can also regulate the expression of members of the CYP3A subfamily, with reports of mainly suppressive effects on mouse hepatic Cyp3a11 expression, but paradoxically both inductive and suppressive effects on human hepatic CYP3A4 expression. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 336-343 30573465-1 2019 Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that activate the aryl hydrocarbon receptor, thereby triggering a range of biologic responses, exemplified by the induction of CYP1A1 PAHs can also regulate the expression of members of the CYP3A subfamily, with reports of mainly suppressive effects on mouse hepatic Cyp3a11 expression, but paradoxically both inductive and suppressive effects on human hepatic CYP3A4 expression. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 430-436 30573465-1 2019 Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that activate the aryl hydrocarbon receptor, thereby triggering a range of biologic responses, exemplified by the induction of CYP1A1 PAHs can also regulate the expression of members of the CYP3A subfamily, with reports of mainly suppressive effects on mouse hepatic Cyp3a11 expression, but paradoxically both inductive and suppressive effects on human hepatic CYP3A4 expression. Polycyclic Aromatic Hydrocarbons 34-38 aryl-hydrocarbon receptor Mus musculus 87-112 30573465-1 2019 Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that activate the aryl hydrocarbon receptor, thereby triggering a range of biologic responses, exemplified by the induction of CYP1A1 PAHs can also regulate the expression of members of the CYP3A subfamily, with reports of mainly suppressive effects on mouse hepatic Cyp3a11 expression, but paradoxically both inductive and suppressive effects on human hepatic CYP3A4 expression. Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 196-202 30573465-1 2019 Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that activate the aryl hydrocarbon receptor, thereby triggering a range of biologic responses, exemplified by the induction of CYP1A1 PAHs can also regulate the expression of members of the CYP3A subfamily, with reports of mainly suppressive effects on mouse hepatic Cyp3a11 expression, but paradoxically both inductive and suppressive effects on human hepatic CYP3A4 expression. Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450, family 3, subfamily a, polypeptide 11 Mus musculus 336-343 30573465-1 2019 Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that activate the aryl hydrocarbon receptor, thereby triggering a range of biologic responses, exemplified by the induction of CYP1A1 PAHs can also regulate the expression of members of the CYP3A subfamily, with reports of mainly suppressive effects on mouse hepatic Cyp3a11 expression, but paradoxically both inductive and suppressive effects on human hepatic CYP3A4 expression. Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 430-436 30616058-6 2019 The genotoxic potency was confirmed in both HBEC and HepG2 cells following exposure to oxy-PAHs by an increased level of phospho-Chk1, a biomarker used to estimate the carcinogenic potency of PAHs in vitro. Polycyclic Aromatic Hydrocarbons 91-95 checkpoint kinase 1 Homo sapiens 129-133 30644759-5 2019 Also addressed are the AHR dependent formation of estrogenic metabolites from polycyclic aromatic hydrocarbons and the possible impact of the ER/AHR crosstalk in the context of drug metabolism. Polycyclic Aromatic Hydrocarbons 78-110 aryl hydrocarbon receptor Homo sapiens 23-26 30316103-5 2019 PAHs and dioxins are known aryl hydrocarbon receptor (AHR) ligands. Polycyclic Aromatic Hydrocarbons 0-4 aryl-hydrocarbon receptor Mus musculus 27-52 30503853-2 2019 DEP, extractable organic material from DEP (DEP-EOM) and certain PAHs seem to trigger [Ca2+]i increase as well as inflammation via GPCRs like betaARs and PAR-2. Polycyclic Aromatic Hydrocarbons 65-69 F2R like trypsin receptor 1 Homo sapiens 154-159 30611761-6 2019 PAHs are ubiquitous environmental toxicants and known aryl hydrocarbon receptor (AHR) ligands. Polycyclic Aromatic Hydrocarbons 0-4 aryl hydrocarbon receptor Homo sapiens 54-79 30611761-6 2019 PAHs are ubiquitous environmental toxicants and known aryl hydrocarbon receptor (AHR) ligands. Polycyclic Aromatic Hydrocarbons 0-4 aryl hydrocarbon receptor Homo sapiens 81-84 29934778-6 2019 However, 10 muM PAHs induced a depleted tGSH reduction compared to single Ni without a change in cell mortality. Polycyclic Aromatic Hydrocarbons 16-20 latexin Homo sapiens 12-15 30523529-1 2019 It is reported that the accumulated polycyclic aromatic hydrocarbons (PAHs) can cause wheat leaf chlorosis, and we identified that carotenoid (Car) and superoxide dismutase (SOD) are the two most active factors in antioxidant system in the previous study. Polycyclic Aromatic Hydrocarbons 36-68 SOD Triticum aestivum 152-172 30523529-1 2019 It is reported that the accumulated polycyclic aromatic hydrocarbons (PAHs) can cause wheat leaf chlorosis, and we identified that carotenoid (Car) and superoxide dismutase (SOD) are the two most active factors in antioxidant system in the previous study. Polycyclic Aromatic Hydrocarbons 36-68 SOD Triticum aestivum 174-177 30523529-1 2019 It is reported that the accumulated polycyclic aromatic hydrocarbons (PAHs) can cause wheat leaf chlorosis, and we identified that carotenoid (Car) and superoxide dismutase (SOD) are the two most active factors in antioxidant system in the previous study. Polycyclic Aromatic Hydrocarbons 70-74 SOD Triticum aestivum 152-172 30523529-1 2019 It is reported that the accumulated polycyclic aromatic hydrocarbons (PAHs) can cause wheat leaf chlorosis, and we identified that carotenoid (Car) and superoxide dismutase (SOD) are the two most active factors in antioxidant system in the previous study. Polycyclic Aromatic Hydrocarbons 70-74 SOD Triticum aestivum 174-177 30707373-8 2019 Under the optimum conditions, limits of detection (at an S/N ratio of 3) range from 3 to 10 pg mL-1, and the analytical ranges are linear at 0.01-100 ng mL-1 of PAHs. Polycyclic Aromatic Hydrocarbons 161-165 L1 cell adhesion molecule Mus musculus 95-99 30707373-8 2019 Under the optimum conditions, limits of detection (at an S/N ratio of 3) range from 3 to 10 pg mL-1, and the analytical ranges are linear at 0.01-100 ng mL-1 of PAHs. Polycyclic Aromatic Hydrocarbons 161-165 L1 cell adhesion molecule Mus musculus 153-157 30665459-0 2019 Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 90-122 paired box 3 Mus musculus 24-28 30665459-9 2019 And mean methylation intensity in the body region of PAX3 in fetal neural tissues was positively correlated with median concentrations of PAH in maternal serum. Polycyclic Aromatic Hydrocarbons 138-141 paired box 3 Mus musculus 53-57 30766605-2 2019 PAHs are potent inducers of the aryl hydrocarbon receptor (AhR), which is an expressed nuclear receptor that senses environmental stimuli and modulates gene expression. Polycyclic Aromatic Hydrocarbons 0-4 aryl hydrocarbon receptor Homo sapiens 32-57 30766605-2 2019 PAHs are potent inducers of the aryl hydrocarbon receptor (AhR), which is an expressed nuclear receptor that senses environmental stimuli and modulates gene expression. Polycyclic Aromatic Hydrocarbons 0-4 aryl hydrocarbon receptor Homo sapiens 59-62 30628281-4 2019 The concentration of PAHs ranges from 4.38 to 2005.02 ng L-1, with an average value of (414.64+-526.13) ng L-1. Polycyclic Aromatic Hydrocarbons 21-25 immunoglobulin kappa variable 1-16 Homo sapiens 57-60 30628281-4 2019 The concentration of PAHs ranges from 4.38 to 2005.02 ng L-1, with an average value of (414.64+-526.13) ng L-1. Polycyclic Aromatic Hydrocarbons 21-25 immunoglobulin kappa variable 1-16 Homo sapiens 107-110 30628281-6 2019 The 3-4 ring PAHs are dominant; the average value was (190.93+-238.96) ng L-1 and (140.01+-234.69) ng L-1, respectively, accounting for 80% of the total PAHs. Polycyclic Aromatic Hydrocarbons 13-17 immunoglobulin kappa variable 1-16 Homo sapiens 74-77 30628281-6 2019 The 3-4 ring PAHs are dominant; the average value was (190.93+-238.96) ng L-1 and (140.01+-234.69) ng L-1, respectively, accounting for 80% of the total PAHs. Polycyclic Aromatic Hydrocarbons 13-17 immunoglobulin kappa variable 1-16 Homo sapiens 102-105 30412887-0 2019 Spatial, seasonal and particle size dependent variations of PAH contamination in indoor dust and the corresponding human health risk. Polycyclic Aromatic Hydrocarbons 60-63 thymus, brain and testes associated Homo sapiens 0-7 30742151-3 2019 Among the polycyclic aromatic hydrocarbons, the centropolyindanes are special because of the saturated core of sp3-hybridised carbon atoms embedded in a three-dimensional environment of aromatic building blocks. Polycyclic Aromatic Hydrocarbons 10-42 Sp3 transcription factor Homo sapiens 111-114 30601487-0 2019 CTAB-triggered Ag aggregates for reproducible SERS analysis of urinary polycyclic aromatic hydrocarbon metabolites. Polycyclic Aromatic Hydrocarbons 71-102 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 46-50 30601487-2 2019 In particular, we demonstrated its use in a SERS-based assay for urinary hydroxylated polycyclic aromatic hydrocarbons (OH-PAHs) with high sensitivity and reproducibility. Polycyclic Aromatic Hydrocarbons 86-118 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 44-48 30760301-5 2019 Zip code residential levels of airborne PAHs and metals (arsenic, cadmium, chromium, cobalt, lead, manganese, mercury, nickel, and selenium) were assessed using the 2011 EPA National Air Toxics Assessment. Polycyclic Aromatic Hydrocarbons 40-44 death associated protein kinase 3 Homo sapiens 0-3 30419384-9 2019 Importantly, a decreasing trend of PAHs was observed in multimedia from 2012 to 2020 and the transfer flux from the air to vegetation to soil was the dominant pathways of BaP intermedia circulation processes. Polycyclic Aromatic Hydrocarbons 35-39 prohibitin 2 Homo sapiens 171-174 30293161-5 2019 This review summarized that (1) the roles of PAHs in asthma-work as risk factors; (2) the possible mechanisms involved in PAH-related asthma-through immunologic and oxidative stress changes; (3) the interactions between PAHs and EPHX1 involved in asthma-enzymatic activity of epoxide hydrolase 1, which affected by EPHX1 genotypes/SNPs/diplotypes, could influence human PAH metabolism and people"s vulnerability to PAH exposure. Polycyclic Aromatic Hydrocarbons 45-49 phenylalanine hydroxylase Homo sapiens 122-125 30293161-5 2019 This review summarized that (1) the roles of PAHs in asthma-work as risk factors; (2) the possible mechanisms involved in PAH-related asthma-through immunologic and oxidative stress changes; (3) the interactions between PAHs and EPHX1 involved in asthma-enzymatic activity of epoxide hydrolase 1, which affected by EPHX1 genotypes/SNPs/diplotypes, could influence human PAH metabolism and people"s vulnerability to PAH exposure. Polycyclic Aromatic Hydrocarbons 45-49 phenylalanine hydroxylase Homo sapiens 122-125 30293161-5 2019 This review summarized that (1) the roles of PAHs in asthma-work as risk factors; (2) the possible mechanisms involved in PAH-related asthma-through immunologic and oxidative stress changes; (3) the interactions between PAHs and EPHX1 involved in asthma-enzymatic activity of epoxide hydrolase 1, which affected by EPHX1 genotypes/SNPs/diplotypes, could influence human PAH metabolism and people"s vulnerability to PAH exposure. Polycyclic Aromatic Hydrocarbons 220-224 phenylalanine hydroxylase Homo sapiens 122-125 30293161-5 2019 This review summarized that (1) the roles of PAHs in asthma-work as risk factors; (2) the possible mechanisms involved in PAH-related asthma-through immunologic and oxidative stress changes; (3) the interactions between PAHs and EPHX1 involved in asthma-enzymatic activity of epoxide hydrolase 1, which affected by EPHX1 genotypes/SNPs/diplotypes, could influence human PAH metabolism and people"s vulnerability to PAH exposure. Polycyclic Aromatic Hydrocarbons 220-224 phenylalanine hydroxylase Homo sapiens 122-125 30530162-4 2019 OBJECTIVES: We sought to evaluate exposure to PAHs among participants in Wave 1 (2013-2014) of the Population Assessment of Tobacco and Health (PATH) Study based on the type of tobacco product (combustible vs non-combustible), and frequency and intensity of product use. Polycyclic Aromatic Hydrocarbons 46-50 WASP family member 1 Homo sapiens 73-79 30528015-7 2019 However, the maize-assisted mycoremediation treatment significantly boosted fungal biomass, microbial and manganese peroxidase activity in soil which strongly correlated with the removal of total PAHs. Polycyclic Aromatic Hydrocarbons 196-200 peroxidase 1 Zea mays 116-126 30596495-0 2019 Kinetics of the Hydrogen Abstraction PAH + OH PAH Radical + H2O Reaction Class: An Application of the Reaction Class Transition State Theory (RC-TST) and Structure-Activity Relationship (SAR). Polycyclic Aromatic Hydrocarbons 37-40 thiosulfate sulfurtransferase Homo sapiens 148-151 30596495-1 2019 A reaction class transition state theory (RC-TST) augmented with structure-activity relationship (SAR) methodology is applied to predict high-pressure limit thermal rate constants for hydrogen abstraction by OH radical from polycyclic aromatic hydrocarbons (PAHs) reaction class in the temperature range of 300-3000 K. The rate constants for the reference reaction of C6H6 + OH C6H5 + H2O is calculated by the canonical variational transition state theory (CVT) with small curvature tunneling (SCT). Polycyclic Aromatic Hydrocarbons 225-257 thiosulfate sulfurtransferase Homo sapiens 45-48 30596495-1 2019 A reaction class transition state theory (RC-TST) augmented with structure-activity relationship (SAR) methodology is applied to predict high-pressure limit thermal rate constants for hydrogen abstraction by OH radical from polycyclic aromatic hydrocarbons (PAHs) reaction class in the temperature range of 300-3000 K. The rate constants for the reference reaction of C6H6 + OH C6H5 + H2O is calculated by the canonical variational transition state theory (CVT) with small curvature tunneling (SCT). Polycyclic Aromatic Hydrocarbons 259-263 thiosulfate sulfurtransferase Homo sapiens 45-48 30691489-8 2019 Polycyclic aromatic hydrocarbon (PAH) biotransformation (CYP1A1 and NQO1 (NAD(P)H dehydrogenase (quinone)1)) enzymes, inflammation and oxidative stress in placentas and fetuses were measured. Polycyclic Aromatic Hydrocarbons 0-31 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 57-63 30691489-8 2019 Polycyclic aromatic hydrocarbon (PAH) biotransformation (CYP1A1 and NQO1 (NAD(P)H dehydrogenase (quinone)1)) enzymes, inflammation and oxidative stress in placentas and fetuses were measured. Polycyclic Aromatic Hydrocarbons 0-31 NAD(P)H dehydrogenase, quinone 1 Mus musculus 68-72 30691489-8 2019 Polycyclic aromatic hydrocarbon (PAH) biotransformation (CYP1A1 and NQO1 (NAD(P)H dehydrogenase (quinone)1)) enzymes, inflammation and oxidative stress in placentas and fetuses were measured. Polycyclic Aromatic Hydrocarbons 33-36 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 57-63 30691489-8 2019 Polycyclic aromatic hydrocarbon (PAH) biotransformation (CYP1A1 and NQO1 (NAD(P)H dehydrogenase (quinone)1)) enzymes, inflammation and oxidative stress in placentas and fetuses were measured. Polycyclic Aromatic Hydrocarbons 33-36 NAD(P)H dehydrogenase, quinone 1 Mus musculus 68-72 30508524-5 2019 However, AHR functions are Janus faced: Detrimental AHR functions in vascular tissue are well documented, e.g., upon exposure to polycyclic aromatic hydrocarbons in cigarette smoke leading to oxidative stress and generation of oxidized LDL. Polycyclic Aromatic Hydrocarbons 129-161 aryl hydrocarbon receptor Homo sapiens 9-12 30508524-5 2019 However, AHR functions are Janus faced: Detrimental AHR functions in vascular tissue are well documented, e.g., upon exposure to polycyclic aromatic hydrocarbons in cigarette smoke leading to oxidative stress and generation of oxidized LDL. Polycyclic Aromatic Hydrocarbons 129-161 aryl hydrocarbon receptor Homo sapiens 52-55 30316103-5 2019 PAHs and dioxins are known aryl hydrocarbon receptor (AHR) ligands. Polycyclic Aromatic Hydrocarbons 0-4 aryl-hydrocarbon receptor Mus musculus 54-57 30660291-0 2019 Bioavailability and distribution of PAHs and PCBs in the sediment pore water of the German Bight and Wadden Sea. Polycyclic Aromatic Hydrocarbons 36-40 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 108-111 30273845-1 2018 A dynamic multimedia transport (DMT) model for polycyclic aromatic hydrocarbons (PAHs) was constructed using the system dynamics software STELLA to simulate the transmission and flow of PAHs in different media. Polycyclic Aromatic Hydrocarbons 81-85 developmental pluripotency associated 3 Homo sapiens 138-144 30576387-0 2018 Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 136-161 30576387-0 2018 Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 163-166 30576387-0 2018 Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 136-161 30576387-0 2018 Polycyclic aromatic hydrocarbons (PAHs) present in ambient urban dust drive proinflammatory T cell and dendritic cell responses via the aryl hydrocarbon receptor (AHR) in vitro. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 163-166 30576387-3 2018 PAHs are ubiquitous environmental toxicants and known aryl hydrocarbon receptor (AHR) ligands. Polycyclic Aromatic Hydrocarbons 0-4 aryl hydrocarbon receptor Homo sapiens 54-79 30576387-3 2018 PAHs are ubiquitous environmental toxicants and known aryl hydrocarbon receptor (AHR) ligands. Polycyclic Aromatic Hydrocarbons 0-4 aryl hydrocarbon receptor Homo sapiens 81-84 30576387-5 2018 Activation of the AHR leads to upregulation of cytochrome P450 (CYP) metabolizing enzymes which are important for the biotransformation of toxicants to less toxic, or in the case of PAHs, more toxic intermediates. Polycyclic Aromatic Hydrocarbons 182-186 aryl hydrocarbon receptor Homo sapiens 18-21 30576387-5 2018 Activation of the AHR leads to upregulation of cytochrome P450 (CYP) metabolizing enzymes which are important for the biotransformation of toxicants to less toxic, or in the case of PAHs, more toxic intermediates. Polycyclic Aromatic Hydrocarbons 182-186 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 47-62 30576387-5 2018 Activation of the AHR leads to upregulation of cytochrome P450 (CYP) metabolizing enzymes which are important for the biotransformation of toxicants to less toxic, or in the case of PAHs, more toxic intermediates. Polycyclic Aromatic Hydrocarbons 182-186 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 64-67 30576387-11 2018 SRM1649b PAH mixtures enhanced Th17 differentiation in an AHR-dependent but CYP-independent manner and increased the percent of IFNgamma positive DCs. Polycyclic Aromatic Hydrocarbons 9-12 aryl hydrocarbon receptor Homo sapiens 58-61 30576387-11 2018 SRM1649b PAH mixtures enhanced Th17 differentiation in an AHR-dependent but CYP-independent manner and increased the percent of IFNgamma positive DCs. Polycyclic Aromatic Hydrocarbons 9-12 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 76-79 30576387-11 2018 SRM1649b PAH mixtures enhanced Th17 differentiation in an AHR-dependent but CYP-independent manner and increased the percent of IFNgamma positive DCs. Polycyclic Aromatic Hydrocarbons 9-12 interferon gamma Homo sapiens 128-136 30448188-1 2018 Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast cancers. Polycyclic Aromatic Hydrocarbons 108-140 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-33 28374118-3 2018 Feeble interactions of BAX and Bcl-2 with diol-epoxides of both PAHs were observed. Polycyclic Aromatic Hydrocarbons 64-68 BCL2 associated X, apoptosis regulator Homo sapiens 23-26 28374118-3 2018 Feeble interactions of BAX and Bcl-2 with diol-epoxides of both PAHs were observed. Polycyclic Aromatic Hydrocarbons 64-68 BCL2 apoptosis regulator Homo sapiens 31-36 30503465-3 2018 Dissolved 15[PAH] in seawater ranged from 5.42 to 34.37 ng L-1, and the level of PAHs was markedly different on each side of the strait. Polycyclic Aromatic Hydrocarbons 14-17 immunoglobulin kappa variable 1-16 Homo sapiens 60-63 30165701-1 2018 We previously reported that mitochondrial CYP1 enzymes participate in the metabolism of polycyclic aromatic hydrocarbons and other carcinogens leading to mitochondrial dysfunction. Polycyclic Aromatic Hydrocarbons 88-120 cytochrome P450, family 27, subfamily b, polypeptide 1 Mus musculus 42-46 30092389-7 2018 Antioxidant defense of glutathione S-transferase and the induction of micronuclei and nuclear buds, the latter just for the bivalve, were significantly affected by polycyclic aromatic hydrocarbons, with significant increases on the seventh day of exposure and in the higher concentrations, compared to controls groups. Polycyclic Aromatic Hydrocarbons 164-196 glutathione S-transferase kappa 1 Homo sapiens 23-48 30142607-3 2018 Fluoranthene (Flt) was the most commonly occurring among the 16 priority PAHs, and benzo(a)pyrene (BaP) accounted for the largest portion of the total carcinogenic potency of PAHs in PM2.5. Polycyclic Aromatic Hydrocarbons 175-179 prohibitin 2 Homo sapiens 99-102 30460410-4 2018 The resulting Fe3O4/KAP is shown to be a viable magnetic sorbent for various organic materials such as the phenylurea herbicides (PUHs), including metoxuron, monuron, chlortoluron, monolinuron and buturon, and also for various phthalates, polycyclic aromatic hydrocarbons and chlorophenols. Polycyclic Aromatic Hydrocarbons 239-271 napsin A aspartic peptidase Homo sapiens 20-23 30255542-0 2018 NBN-Doped Conjugated Polycyclic Aromatic Hydrocarbons as an AIEgen Class for Extremely Sensitive Detection of Explosives. Polycyclic Aromatic Hydrocarbons 21-53 nibrin Homo sapiens 0-3 30255542-1 2018 A simple and efficient synthesis of NBN-doped conjugated polycyclic aromatic hydrocarbons (such as diazaborinines) has been accomplished by a catalyst-free intermolecular dehydration reaction at room temperature between boronic acid and diamine moieties with yields up to 99 %. Polycyclic Aromatic Hydrocarbons 57-89 nibrin Homo sapiens 36-39 30255542-2 2018 Polycyclic aromatic hydrocarbons with a six-membered NBN ring are a new class of aggregation-induced emissive luminogens. Polycyclic Aromatic Hydrocarbons 0-32 nibrin Homo sapiens 53-56 30021174-2 2018 In the present study, the sorption efficiency of PAHs by sorptive sinks including silica, poly(ethylene-co-vinyl acetate) (polyE), tenax, and C18 were compared with that by caco-2 cells. Polycyclic Aromatic Hydrocarbons 49-53 Bardet-Biedl syndrome 9 Homo sapiens 142-145 30574142-9 2018 The AHR is a ligand activated transcription factor that responds to endogenous and exogenous ligands including toxicants present in PM, such as PAHs and dioxins. Polycyclic Aromatic Hydrocarbons 144-148 aryl-hydrocarbon receptor Mus musculus 4-7 31950709-2 2018 In contrast to the previous work on direct (poly)substitutions with RF groups in polycyclic aromatic hydrocarbons (PAHs), in this work regiospecificity, selectivity, and high yield were achieved for TRPH(C4 F8 ) and TRPH(C4 F8 )3 . Polycyclic Aromatic Hydrocarbons 81-113 tryptophan hydroxylase 1 Homo sapiens 199-209 31950709-2 2018 In contrast to the previous work on direct (poly)substitutions with RF groups in polycyclic aromatic hydrocarbons (PAHs), in this work regiospecificity, selectivity, and high yield were achieved for TRPH(C4 F8 ) and TRPH(C4 F8 )3 . Polycyclic Aromatic Hydrocarbons 81-113 tryptophan hydroxylase 1 Homo sapiens 216-226 31950709-2 2018 In contrast to the previous work on direct (poly)substitutions with RF groups in polycyclic aromatic hydrocarbons (PAHs), in this work regiospecificity, selectivity, and high yield were achieved for TRPH(C4 F8 ) and TRPH(C4 F8 )3 . Polycyclic Aromatic Hydrocarbons 115-119 tryptophan hydroxylase 1 Homo sapiens 199-209 31950709-2 2018 In contrast to the previous work on direct (poly)substitutions with RF groups in polycyclic aromatic hydrocarbons (PAHs), in this work regiospecificity, selectivity, and high yield were achieved for TRPH(C4 F8 ) and TRPH(C4 F8 )3 . Polycyclic Aromatic Hydrocarbons 115-119 tryptophan hydroxylase 1 Homo sapiens 216-226 30248604-0 2018 Mediation effect of AhR expression between polycyclic aromatic hydrocarbons exposure and oxidative DNA damage among Chinese occupational workers. Polycyclic Aromatic Hydrocarbons 43-75 aryl hydrocarbon receptor Homo sapiens 20-23 30248604-1 2018 Polycyclic aromatic hydrocarbons (PAH) are well-known to be carcinogenic and the mechanisms that it contributes to oxidative DNA damage and aryl hydrocarbon receptor (AhR)-dependent induction are also well understood. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 140-165 30248604-1 2018 Polycyclic aromatic hydrocarbons (PAH) are well-known to be carcinogenic and the mechanisms that it contributes to oxidative DNA damage and aryl hydrocarbon receptor (AhR)-dependent induction are also well understood. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 167-170 30248604-1 2018 Polycyclic aromatic hydrocarbons (PAH) are well-known to be carcinogenic and the mechanisms that it contributes to oxidative DNA damage and aryl hydrocarbon receptor (AhR)-dependent induction are also well understood. Polycyclic Aromatic Hydrocarbons 34-37 aryl hydrocarbon receptor Homo sapiens 140-165 30248604-1 2018 Polycyclic aromatic hydrocarbons (PAH) are well-known to be carcinogenic and the mechanisms that it contributes to oxidative DNA damage and aryl hydrocarbon receptor (AhR)-dependent induction are also well understood. Polycyclic Aromatic Hydrocarbons 34-37 aryl hydrocarbon receptor Homo sapiens 167-170 30248604-2 2018 However, little is known about the associations between PAH exposure, AhR expression, and oxidative DNA damage. Polycyclic Aromatic Hydrocarbons 56-59 aryl hydrocarbon receptor Homo sapiens 70-73 30248604-3 2018 We investigated their associations of AhR expression and oxidative DNA damage related to PAH exposure among 310 workers from a coke-oven plant in China. Polycyclic Aromatic Hydrocarbons 89-92 aryl hydrocarbon receptor Homo sapiens 38-41 30248604-9 2018 In addition, mediation analysis showed the AhR expression could explain 35.9% of the association of oxidative DNA damage related to PAH exposure. Polycyclic Aromatic Hydrocarbons 132-135 aryl hydrocarbon receptor Homo sapiens 43-46 30248604-10 2018 Our findings implicated that the association between PAH exposure and oxidative DNA damage may be mediated by AhR expression among Chinese occupational workers. Polycyclic Aromatic Hydrocarbons 53-56 aryl hydrocarbon receptor Homo sapiens 110-113 30448188-1 2018 Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast cancers. Polycyclic Aromatic Hydrocarbons 108-140 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 35-41 30448188-1 2018 Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast cancers. Polycyclic Aromatic Hydrocarbons 108-140 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 176-182 30448188-1 2018 Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast cancers. Polycyclic Aromatic Hydrocarbons 142-146 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-33 30448188-1 2018 Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast cancers. Polycyclic Aromatic Hydrocarbons 142-146 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 35-41 30448188-1 2018 Expression of cytochrome P450-1A1 (CYP1A1) is suppressed under physiologic conditions but is induced (a) by polycyclic aromatic hydrocarbons (PAHs) which can be metabolized by CYP1A1 to carcinogens, and (b) in majority of breast cancers. Polycyclic Aromatic Hydrocarbons 142-146 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 176-182 30448188-2 2018 Hence, phytochemicals or dietary flavonoids, if identified as CYP1A1 inhibitors, may help in preventing PAH-mediated carcinogenesis and breast cancer. Polycyclic Aromatic Hydrocarbons 104-107 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-68 30032761-3 2018 This study, moreover, shows that intrinsically poorer ionization efficiencies for low-polarity compounds (such as polycyclic aromatic hydrocarbons, PAHs), which precluded their ultra-trace detection, can be partially overcome by adding dopants and lowering the LODs into the pg mL-1 range. Polycyclic Aromatic Hydrocarbons 114-146 L1 cell adhesion molecule Mus musculus 278-282 30032761-3 2018 This study, moreover, shows that intrinsically poorer ionization efficiencies for low-polarity compounds (such as polycyclic aromatic hydrocarbons, PAHs), which precluded their ultra-trace detection, can be partially overcome by adding dopants and lowering the LODs into the pg mL-1 range. Polycyclic Aromatic Hydrocarbons 148-152 L1 cell adhesion molecule Mus musculus 278-282 30405070-6 2018 Carcinogenic potency of PAHs was estimated by calculating benzo(a)pyrene equivalent concentrations while using three different toxic equivalence factor (TEF) schemes. Polycyclic Aromatic Hydrocarbons 24-28 TEF transcription factor, PAR bZIP family member Homo sapiens 153-156 30251528-5 2018 Here we examine the photodegradation of two common PAHs, anthracene and pyrene, in/on ice and in solution. Polycyclic Aromatic Hydrocarbons 51-55 carboxylesterase 2 Homo sapiens 86-89 30251528-6 2018 For a given PAH, rate constants are similar in aqueous solution, in internal liquid-like regions of ice, and at the air-ice interface. Polycyclic Aromatic Hydrocarbons 12-15 carboxylesterase 2 Homo sapiens 100-103 30251528-6 2018 For a given PAH, rate constants are similar in aqueous solution, in internal liquid-like regions of ice, and at the air-ice interface. Polycyclic Aromatic Hydrocarbons 12-15 carboxylesterase 2 Homo sapiens 120-123 30025340-7 2018 In this study, switching from HSF (1.12% S) to LSF (0.38% S) reduced emitted PM by 12%, OC by 20%, sulfate by 71%, and particulate PAHs by 94%, but caused an increase in single-ring aromatics. Polycyclic Aromatic Hydrocarbons 131-135 interleukin 6 Homo sapiens 30-33 30071435-2 2018 This study investigated the influence of the LLT-ESP on polycyclic aromatic hydrocarbons (PAHs) distributions in flue gas from an ultra-low emission coal-fired power plant. Polycyclic Aromatic Hydrocarbons 56-88 Epidermal stripes and patches Drosophila melanogaster 49-52 30071435-5 2018 The removal efficiency of the LLT-ESP for gas-phase and particulate phase carcinogenic higher molecular weight (HMW) PAHs was 85% and 99%, respectively. Polycyclic Aromatic Hydrocarbons 117-121 Epidermal stripes and patches Drosophila melanogaster 34-37 30097281-10 2018 In conclusion, elevated exposure to PAHs can accelerate the TL shortening and this effect can be modified by TERT-CLPTM1L variants. Polycyclic Aromatic Hydrocarbons 36-40 telomerase reverse transcriptase Homo sapiens 109-113 30097281-10 2018 In conclusion, elevated exposure to PAHs can accelerate the TL shortening and this effect can be modified by TERT-CLPTM1L variants. Polycyclic Aromatic Hydrocarbons 36-40 CLPTM1 like Homo sapiens 114-121 30086953-5 2018 Limits of detection in the range 1.0-1.4 ng mL-1 were achieved for the target polycyclic aromatic hydrocarbons, allowing their determination in about 9 min per sample in leaves of different types of tea. Polycyclic Aromatic Hydrocarbons 78-110 L1 cell adhesion molecule Mus musculus 44-48 30010761-1 2018 Objectives: The main aim of this study was to assess the biological uptake of benzene and polycyclic aromatic hydrocarbons (PAHs) for subjects exposed to fresh crude oil released at sea. Polycyclic Aromatic Hydrocarbons 124-128 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 182-185 28403014-6 2018 NAT2 slow genotype carriers had an OR of 3.59 (95% CI: 2.62-4.93) for BC when exposed to aromatic amines and an OR of 2.07 (95% CI: 1.36-3.15) when exposed to PAHs. Polycyclic Aromatic Hydrocarbons 159-163 N-acetyltransferase 2 Homo sapiens 0-4 30144900-1 2018 BACKGROUND & AIMS: The process of grilling food items often generates polycyclic aromatic hydrocarbons which are established inducers of CYP1A2, a human drug metabolising enzyme, known to activate some procarcinogens. Polycyclic Aromatic Hydrocarbons 74-106 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 141-147 29897406-0 2018 A Needle Trap Device Packed with Nanoporous Silica Sorbents for Separation and Gas Chromatographic Determination of Polycyclic Aromatic Hydrocarbons in Contaminated Soils. Polycyclic Aromatic Hydrocarbons 116-148 TRAP Homo sapiens 9-13 30137621-0 2018 Aryl Hydrocarbon Receptor-Dependent Metabolism Plays a Significant Role in Estrogen-Like Effects of Polycyclic Aromatic Hydrocarbons on Cell Proliferation. Polycyclic Aromatic Hydrocarbons 100-132 aryl hydrocarbon receptor Homo sapiens 0-25 30137621-1 2018 Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that interact in a complex manner with both the aryl hydrocarbon receptor (AhR) and estrogen receptors (ER). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 130-155 30137621-1 2018 Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that interact in a complex manner with both the aryl hydrocarbon receptor (AhR) and estrogen receptors (ER). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 157-160 30137621-1 2018 Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that interact in a complex manner with both the aryl hydrocarbon receptor (AhR) and estrogen receptors (ER). Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 130-155 30137621-1 2018 Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental contaminants that interact in a complex manner with both the aryl hydrocarbon receptor (AhR) and estrogen receptors (ER). Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 157-160 30137621-2 2018 Their potential endocrine-disrupting activities may depend on both inhibitory AhR-ER cross-talk and on AhR-dependent metabolic production of estrogenic PAH metabolites. Polycyclic Aromatic Hydrocarbons 152-155 aryl hydrocarbon receptor Homo sapiens 103-106 30137621-3 2018 Here, we analyzed the impact of AhR on estrogen-like effects of PAHs, such as benzo[a]pyrene (BaP), in particular, on control of cell cycle progression/cell proliferation. Polycyclic Aromatic Hydrocarbons 64-68 aryl hydrocarbon receptor Homo sapiens 32-35 30363692-4 2018 The results indicated that this method showed good linearity (R 2 > 0.995) within 0.5 microg L-1 to 1000 microg L-1 for PAHs. Polycyclic Aromatic Hydrocarbons 123-127 immunoglobulin kappa variable 1-16 Homo sapiens 96-99 30363692-4 2018 The results indicated that this method showed good linearity (R 2 > 0.995) within 0.5 microg L-1 to 1000 microg L-1 for PAHs. Polycyclic Aromatic Hydrocarbons 123-127 immunoglobulin kappa variable 1-16 Homo sapiens 115-118 30188552-1 2018 This work provides a rigorous procedure, within the framework of the Reaction Class Transition State Theory (RC-TST) and the Structure-Activity Relationship (SAR), for predicting reliable thermal rate constants on-the-fly for hydrogen abstraction reactions by methyl/ethyl radicals from Polycyclic Aromatic Hydrocarbons (PAHs) in a temperature range of 300-3000 K. All necessary RC-TST parameters were derived from ab initio calculations for a representative set of 36 reactions on which different error analyses and comparisons with available literature data were carried out. Polycyclic Aromatic Hydrocarbons 287-319 twister Drosophila melanogaster 112-115 30188552-1 2018 This work provides a rigorous procedure, within the framework of the Reaction Class Transition State Theory (RC-TST) and the Structure-Activity Relationship (SAR), for predicting reliable thermal rate constants on-the-fly for hydrogen abstraction reactions by methyl/ethyl radicals from Polycyclic Aromatic Hydrocarbons (PAHs) in a temperature range of 300-3000 K. All necessary RC-TST parameters were derived from ab initio calculations for a representative set of 36 reactions on which different error analyses and comparisons with available literature data were carried out. Polycyclic Aromatic Hydrocarbons 287-319 twister Drosophila melanogaster 382-385 30188552-1 2018 This work provides a rigorous procedure, within the framework of the Reaction Class Transition State Theory (RC-TST) and the Structure-Activity Relationship (SAR), for predicting reliable thermal rate constants on-the-fly for hydrogen abstraction reactions by methyl/ethyl radicals from Polycyclic Aromatic Hydrocarbons (PAHs) in a temperature range of 300-3000 K. All necessary RC-TST parameters were derived from ab initio calculations for a representative set of 36 reactions on which different error analyses and comparisons with available literature data were carried out. Polycyclic Aromatic Hydrocarbons 321-325 twister Drosophila melanogaster 112-115 30188552-1 2018 This work provides a rigorous procedure, within the framework of the Reaction Class Transition State Theory (RC-TST) and the Structure-Activity Relationship (SAR), for predicting reliable thermal rate constants on-the-fly for hydrogen abstraction reactions by methyl/ethyl radicals from Polycyclic Aromatic Hydrocarbons (PAHs) in a temperature range of 300-3000 K. All necessary RC-TST parameters were derived from ab initio calculations for a representative set of 36 reactions on which different error analyses and comparisons with available literature data were carried out. Polycyclic Aromatic Hydrocarbons 321-325 twister Drosophila melanogaster 382-385 29787794-7 2018 Moreover, polycyclic aromatic hydrocarbons (PAHs) contained in the PM also induced Egr-1 expression, and also played a role in the inflammatory responses and mucus production. Polycyclic Aromatic Hydrocarbons 10-42 early growth response 1 Homo sapiens 83-88 29787794-7 2018 Moreover, polycyclic aromatic hydrocarbons (PAHs) contained in the PM also induced Egr-1 expression, and also played a role in the inflammatory responses and mucus production. Polycyclic Aromatic Hydrocarbons 44-48 early growth response 1 Homo sapiens 83-88 29968107-4 2018 The selectivity towards polycyclic aromatic hydrocarbons relative to that towards alkylbenzenes exhibited by the prepared column was higher than the corresponding selectivity exhibited by commercial C18 column, which could be explained by electronic pi-pi interaction between phenylglycine and electron-rich aromatic rings. Polycyclic Aromatic Hydrocarbons 24-56 Bardet-Biedl syndrome 9 Homo sapiens 199-202 28403014-8 2018 This meta-analysis indicates a possible association between the variant genotypes of GSTM1, GSTT1, NAT2 and SULT1A1, occupational exposure to aromatic amines or PAHs, and development of BC. Polycyclic Aromatic Hydrocarbons 161-165 glutathione S-transferase mu 1 Homo sapiens 85-90 28403014-8 2018 This meta-analysis indicates a possible association between the variant genotypes of GSTM1, GSTT1, NAT2 and SULT1A1, occupational exposure to aromatic amines or PAHs, and development of BC. Polycyclic Aromatic Hydrocarbons 161-165 glutathione S-transferase theta 1 Homo sapiens 92-97 28403014-8 2018 This meta-analysis indicates a possible association between the variant genotypes of GSTM1, GSTT1, NAT2 and SULT1A1, occupational exposure to aromatic amines or PAHs, and development of BC. Polycyclic Aromatic Hydrocarbons 161-165 N-acetyltransferase 2 Homo sapiens 99-103 28403014-8 2018 This meta-analysis indicates a possible association between the variant genotypes of GSTM1, GSTT1, NAT2 and SULT1A1, occupational exposure to aromatic amines or PAHs, and development of BC. Polycyclic Aromatic Hydrocarbons 161-165 sulfotransferase family 1A member 1 Homo sapiens 108-115 30288206-3 2018 Reported herein is the rapid, sensitive, and selective detection of 10 PAHs and PAH metabolites in a variety of cow milks and plant milk alternatives using fluorescence energy transfer from the PAH to a high quantum yield fluorophore, combined with subsequent array-based statistical analyses of the fluorescence emission signals. Polycyclic Aromatic Hydrocarbons 71-75 Weaning weight-maternal milk Bos taurus 116-120 29857962-5 2018 RESULTS: We observed an increased expression of oxidative stress response protein NRF2, upon chronic exposure of primary keratinocytes to DPE/its vapor which includes volatile components such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 195-227 NFE2 like bZIP transcription factor 2 Homo sapiens 82-86 29857962-5 2018 RESULTS: We observed an increased expression of oxidative stress response protein NRF2, upon chronic exposure of primary keratinocytes to DPE/its vapor which includes volatile components such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 229-233 NFE2 like bZIP transcription factor 2 Homo sapiens 82-86 30143013-13 2018 Additionally, both synthetic PAH mixtures that represent specific PAHs found in the two diesel PM samples enhanced Th17 differentiation, however one lost this effect after metabolism and only one required the AHR. Polycyclic Aromatic Hydrocarbons 29-32 aryl hydrocarbon receptor Homo sapiens 209-212 30230272-12 2018 Gene expression profiles suggest that polycyclic aromatic hydrocarbon (PAH) content in PM activated the aryl hydrocarbon receptor (AhR) and enhanced Th17-responses in the mice that received HDM and PM compared to mice that received HDM-only. Polycyclic Aromatic Hydrocarbons 38-69 aryl-hydrocarbon receptor Mus musculus 104-129 30230272-12 2018 Gene expression profiles suggest that polycyclic aromatic hydrocarbon (PAH) content in PM activated the aryl hydrocarbon receptor (AhR) and enhanced Th17-responses in the mice that received HDM and PM compared to mice that received HDM-only. Polycyclic Aromatic Hydrocarbons 38-69 aryl-hydrocarbon receptor Mus musculus 131-134 30230272-12 2018 Gene expression profiles suggest that polycyclic aromatic hydrocarbon (PAH) content in PM activated the aryl hydrocarbon receptor (AhR) and enhanced Th17-responses in the mice that received HDM and PM compared to mice that received HDM-only. Polycyclic Aromatic Hydrocarbons 71-74 aryl-hydrocarbon receptor Mus musculus 104-129 30230272-12 2018 Gene expression profiles suggest that polycyclic aromatic hydrocarbon (PAH) content in PM activated the aryl hydrocarbon receptor (AhR) and enhanced Th17-responses in the mice that received HDM and PM compared to mice that received HDM-only. Polycyclic Aromatic Hydrocarbons 71-74 aryl-hydrocarbon receptor Mus musculus 131-134 30243371-2 2018 Following oil spills, cetaceans at the water surface may inhale droplets of oil containing toxic polycyclic aromatic hydrocarbons (PAHs), which could potentially alter respiratory immunity via activation of the aryl hydrocarbon receptor (AHR) and its subsequent interaction with nuclear factor kappa B (NF-kappaB). Polycyclic Aromatic Hydrocarbons 97-129 LOC522736 Bos taurus 211-236 30243371-2 2018 Following oil spills, cetaceans at the water surface may inhale droplets of oil containing toxic polycyclic aromatic hydrocarbons (PAHs), which could potentially alter respiratory immunity via activation of the aryl hydrocarbon receptor (AHR) and its subsequent interaction with nuclear factor kappa B (NF-kappaB). Polycyclic Aromatic Hydrocarbons 97-129 LOC522736 Bos taurus 238-241 30243371-2 2018 Following oil spills, cetaceans at the water surface may inhale droplets of oil containing toxic polycyclic aromatic hydrocarbons (PAHs), which could potentially alter respiratory immunity via activation of the aryl hydrocarbon receptor (AHR) and its subsequent interaction with nuclear factor kappa B (NF-kappaB). Polycyclic Aromatic Hydrocarbons 131-135 LOC522736 Bos taurus 211-236 30243371-2 2018 Following oil spills, cetaceans at the water surface may inhale droplets of oil containing toxic polycyclic aromatic hydrocarbons (PAHs), which could potentially alter respiratory immunity via activation of the aryl hydrocarbon receptor (AHR) and its subsequent interaction with nuclear factor kappa B (NF-kappaB). Polycyclic Aromatic Hydrocarbons 131-135 LOC522736 Bos taurus 238-241 29758891-1 2018 The involvement of benzo[a]pyrene (BaP) one of the most toxic polycyclic aromatic hydrocarbons (PAHs) in the soil-plant system causes its potential carcinogenicity and mutagenicity for human health. Polycyclic Aromatic Hydrocarbons 62-94 prohibitin 2 Homo sapiens 35-38 29758891-1 2018 The involvement of benzo[a]pyrene (BaP) one of the most toxic polycyclic aromatic hydrocarbons (PAHs) in the soil-plant system causes its potential carcinogenicity and mutagenicity for human health. Polycyclic Aromatic Hydrocarbons 96-100 prohibitin 2 Homo sapiens 35-38 29995397-3 2018 These emerging organic AChE disruptors include certain persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs), and wildly used chemicals, most of which have received considerable public health concern in recent years. Polycyclic Aromatic Hydrocarbons 93-125 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 29995397-3 2018 These emerging organic AChE disruptors include certain persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs), and wildly used chemicals, most of which have received considerable public health concern in recent years. Polycyclic Aromatic Hydrocarbons 127-131 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 29995397-7 2018 AChE activity in certain organisms has been found to be well correlated with the contamination level of certain persistent pesticides and PAHs in particular habitats. Polycyclic Aromatic Hydrocarbons 138-142 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 29751337-1 2018 The biodegradation of low- and high-molecular-weight polycyclic aromatic hydrocarbons (PAHs) (LWM-PAHs and HMW-PAHs, respectively) has been studied extensively under aerobic conditions. Polycyclic Aromatic Hydrocarbons 53-85 cilia and flagella associated protein 97 Homo sapiens 107-110 29763690-1 2018 The environmental polycyclic aromatic hydrocarbons (PAH) and dioxins are carcinogens and their adverse effects have been largely attributed to the activation of AhR. Polycyclic Aromatic Hydrocarbons 18-50 aryl hydrocarbon receptor Homo sapiens 161-164 29763690-1 2018 The environmental polycyclic aromatic hydrocarbons (PAH) and dioxins are carcinogens and their adverse effects have been largely attributed to the activation of AhR. Polycyclic Aromatic Hydrocarbons 52-55 aryl hydrocarbon receptor Homo sapiens 161-164 29704673-1 2018 In this study, we investigated the in situ responses of Red Sea picophytoplankton, the dominant phytoplankton group in the oligotrophic ocean, to two toxic polycyclic aromatic hydrocarbons (PAHs), phenanthrene and pyrene. Polycyclic Aromatic Hydrocarbons 156-188 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 60-63 29704673-1 2018 In this study, we investigated the in situ responses of Red Sea picophytoplankton, the dominant phytoplankton group in the oligotrophic ocean, to two toxic polycyclic aromatic hydrocarbons (PAHs), phenanthrene and pyrene. Polycyclic Aromatic Hydrocarbons 190-194 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 60-63 29845565-0 2018 Associations between sperm quality, DNA damage, and CYP1A1, GSTT1 and GSTM1 polymorphisms with 1-hydroxypyrene urinary levels in men occupationally exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 159-191 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 52-58 29845565-0 2018 Associations between sperm quality, DNA damage, and CYP1A1, GSTT1 and GSTM1 polymorphisms with 1-hydroxypyrene urinary levels in men occupationally exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 159-191 glutathione S-transferase theta 1 Homo sapiens 60-65 29845565-0 2018 Associations between sperm quality, DNA damage, and CYP1A1, GSTT1 and GSTM1 polymorphisms with 1-hydroxypyrene urinary levels in men occupationally exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 159-191 glutathione S-transferase mu 1 Homo sapiens 70-75 29751337-1 2018 The biodegradation of low- and high-molecular-weight polycyclic aromatic hydrocarbons (PAHs) (LWM-PAHs and HMW-PAHs, respectively) has been studied extensively under aerobic conditions. Polycyclic Aromatic Hydrocarbons 87-91 cilia and flagella associated protein 97 Homo sapiens 107-110 29471110-0 2018 Antagonistic and synergistic interactions during the binding of binary mixtures of polycyclic aromatic hydrocarbons to the aryl hydrocarbon receptor. Polycyclic Aromatic Hydrocarbons 83-115 aryl hydrocarbon receptor Rattus norvegicus 123-148 29471110-5 2018 The binding of B(a)P to the aryl hydrocarbon (Ah) receptor was similarly modulated by other PAHs. Polycyclic Aromatic Hydrocarbons 92-96 aryl hydrocarbon receptor Rattus norvegicus 28-58 29471110-6 2018 No correlation was evident between binding avidity of the PAH to the Ah receptor and either its potential for interaction or nature of interaction, e.g. synergism or antagonism. Polycyclic Aromatic Hydrocarbons 58-61 aryl hydrocarbon receptor Rattus norvegicus 69-80 29471110-8 2018 Bearing in mind the role of the Ah receptor in chemical carcinogenesis, it may be concluded that interactions at the Ah receptor site may contribute to the well-established modulation of the carcinogenicity of one PAH in the presence of another. Polycyclic Aromatic Hydrocarbons 214-217 aryl hydrocarbon receptor Rattus norvegicus 32-43 29471110-8 2018 Bearing in mind the role of the Ah receptor in chemical carcinogenesis, it may be concluded that interactions at the Ah receptor site may contribute to the well-established modulation of the carcinogenicity of one PAH in the presence of another. Polycyclic Aromatic Hydrocarbons 214-217 aryl hydrocarbon receptor Rattus norvegicus 117-128 29609169-11 2018 The intensities of these two peaks vary in function of ring number of PAHs, which is likely attributed to Kelvin effect that the less volatile HMW PAH species preferentially condense onto the finer particulates. Polycyclic Aromatic Hydrocarbons 70-73 cilia and flagella associated protein 97 Homo sapiens 143-146 29726971-1 2018 Recent evidence suggests that the interaction of polycyclic aromatic hydrocarbons (PAHs), present in some petroleum substances (PS), with particular nuclear-hormone-receptors and/or the dioxin (aryl hydrocarbon receptor [AhR]) receptor, may play a role in the prenatal developmental toxicity (PDT) induced by these substances. Polycyclic Aromatic Hydrocarbons 49-81 aryl hydrocarbon receptor Homo sapiens 221-224 29726971-1 2018 Recent evidence suggests that the interaction of polycyclic aromatic hydrocarbons (PAHs), present in some petroleum substances (PS), with particular nuclear-hormone-receptors and/or the dioxin (aryl hydrocarbon receptor [AhR]) receptor, may play a role in the prenatal developmental toxicity (PDT) induced by these substances. Polycyclic Aromatic Hydrocarbons 83-87 aryl hydrocarbon receptor Homo sapiens 221-224 29923394-3 2018 In addition, a validated submicro-1-based microsolid-phase extraction (mu-SPE) method for the determination of trace monohydroxylated polycyclic aromatic hydrocarbons in complex human urine was developed with satisfactory sensitivity and good precision by online coupling to liquid chromatography-mass spectrometry, which represents the first example of a mixed-ligand MOF applied as an efficient sorbent for mu-SPE. Polycyclic Aromatic Hydrocarbons 134-166 lysine acetyltransferase 8 Homo sapiens 369-372 29722794-0 2018 DNA methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 103-135 F2R like thrombin or trypsin receptor 3 Homo sapiens 44-49 29722794-0 2018 DNA methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 103-135 aryl hydrocarbon receptor repressor Homo sapiens 54-58 29573714-6 2018 Potency balance analysis revealed that only 3% and 22% of the AhR- and ER-mediated potencies could be explained by identified known chemicals, such as PAHs and APs, respectively. Polycyclic Aromatic Hydrocarbons 151-155 aryl hydrocarbon receptor Homo sapiens 62-65 29458109-2 2018 CYP1A1 has become infamous for its oxidative metabolism of benzo[a]pyrene and related polycyclic aromatic hydrocarbons, converting these chemicals into very potent human carcinogens. Polycyclic Aromatic Hydrocarbons 86-118 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 29458109-3 2018 CYP1A1 expression is mainly controlled by the aryl hydrocarbon receptor (AHR), a transcription factor whose activation is induced by binding of persistent organic pollutants, including polycyclic aromatic hydrocarbons and dioxins. Polycyclic Aromatic Hydrocarbons 185-217 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 29458109-3 2018 CYP1A1 expression is mainly controlled by the aryl hydrocarbon receptor (AHR), a transcription factor whose activation is induced by binding of persistent organic pollutants, including polycyclic aromatic hydrocarbons and dioxins. Polycyclic Aromatic Hydrocarbons 185-217 aryl hydrocarbon receptor Homo sapiens 46-71 29458109-3 2018 CYP1A1 expression is mainly controlled by the aryl hydrocarbon receptor (AHR), a transcription factor whose activation is induced by binding of persistent organic pollutants, including polycyclic aromatic hydrocarbons and dioxins. Polycyclic Aromatic Hydrocarbons 185-217 aryl hydrocarbon receptor Homo sapiens 73-76 29606035-0 2018 The induction of aryl hydrocarbon receptor (AHR) in immune organs of developing chicks by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 90-122 aryl hydrocarbon receptor Homo sapiens 17-42 29606035-0 2018 The induction of aryl hydrocarbon receptor (AHR) in immune organs of developing chicks by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 90-122 aryl hydrocarbon receptor Homo sapiens 44-47 29962921-7 2018 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is recognized as the mediator of halogenated and polycyclic aromatic hydrocarbon toxicities. Polycyclic Aromatic Hydrocarbons 133-164 aryl hydrocarbon receptor Homo sapiens 4-29 29962921-7 2018 The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is recognized as the mediator of halogenated and polycyclic aromatic hydrocarbon toxicities. Polycyclic Aromatic Hydrocarbons 133-164 aryl hydrocarbon receptor Homo sapiens 31-34 29426185-0 2018 Polycyclic aromatic hydrocarbons (PAHs) associated with PM2.5 within boundary layer: Cloud/fog and regional transport. Polycyclic Aromatic Hydrocarbons 0-32 zinc finger protein, FOG family member 1 Homo sapiens 91-94 29426185-0 2018 Polycyclic aromatic hydrocarbons (PAHs) associated with PM2.5 within boundary layer: Cloud/fog and regional transport. Polycyclic Aromatic Hydrocarbons 34-38 zinc finger protein, FOG family member 1 Homo sapiens 91-94 29426185-9 2018 The results demonstrated that the cloud/fog and rain conditions cause lower PAHs levels. Polycyclic Aromatic Hydrocarbons 76-80 zinc finger protein, FOG family member 1 Homo sapiens 40-43 29884199-5 2018 AHR is activated by organic compounds including polycyclic aromatic hydrocarbons (PAHs), which are environmental pollutants that are also present in cigarette smoke. Polycyclic Aromatic Hydrocarbons 48-80 aryl-hydrocarbon receptor Mus musculus 0-3 29884199-5 2018 AHR is activated by organic compounds including polycyclic aromatic hydrocarbons (PAHs), which are environmental pollutants that are also present in cigarette smoke. Polycyclic Aromatic Hydrocarbons 82-86 aryl-hydrocarbon receptor Mus musculus 0-3 29203322-5 2018 Here, we assess the effect of in ovo exposure to the model PAH, benzo[k]fluoranthene (BkF), on aryl hydrocarbon receptor (AHR) mediated cytochrome P4501A (CYP1A) gene expression and promoter methylation in chicken embryos. Polycyclic Aromatic Hydrocarbons 59-62 aryl hydrocarbon receptor 1 alpha Gallus gallus 95-120 29544216-2 2018 The total PAHs concentrations in sediment and water were 86.7-1790 ng g-1 dry weight (dw) and 184-365 ng L-1 in summer and 184-3140 ng g-1 dw and 410-1160 ng L-1 in winter. Polycyclic Aromatic Hydrocarbons 10-14 immunoglobulin kappa variable 1-16 Homo sapiens 105-108 29748474-4 2018 Chemical analysis revealed that the majority of organic matter was extracted by the n-Hex- and DCM-EOM, with polycyclic aromatic hydrocarbons primarily occurring in n-Hex-EOM. Polycyclic Aromatic Hydrocarbons 109-141 hematopoietically expressed homeobox Homo sapiens 167-170 29667677-4 2018 Regarding (i), in this work, we determined the lowest energy structures of PAH-ice systems for a variety of PAHs ranging from naphthalene to ovalene on three types of ice - crystalline (Ih and Ic) and amorphous (low density) - using an explicit description of the electrons and a finite-sized system. Polycyclic Aromatic Hydrocarbons 108-112 phenylalanine hydroxylase Homo sapiens 75-78 29730800-1 2018 To examine ambient air pollutants, specifically polycyclic aromatic hydrocarbons (PAHs), as a factor in the geographic variation of breast cancer incidence seen in the US, we conducted an ecological study involving counties throughout the US to examine breast cancer incidence in relation to PAH emissions in ambient air. Polycyclic Aromatic Hydrocarbons 48-80 phenylalanine hydroxylase Homo sapiens 82-85 29428707-5 2018 Fractions of the gaseous or 3- and 4-ring PAHs (i.e., Flu, Phe, and Ant) were high in summer, and those of the particulate or 5- and 6-ring PAHs (i.e., BkF, BaP, Ind, DahA, and BghiP) increased in winter. Polycyclic Aromatic Hydrocarbons 42-46 solute carrier family 25 member 6 Homo sapiens 68-71 29227942-6 2018 The highest concentration levels of total PAHs were observed in two samples from the tributaries in July 2015 and were 1069ngL-1 and 3141ngL-1 and in September 2015, the highest concentrations were observed in samples collected from Revvatnet lake and were 978ngL-1 and 1823ngL-1. Polycyclic Aromatic Hydrocarbons 42-46 leucine rich repeat containing 4C Homo sapiens 123-128 29227942-6 2018 The highest concentration levels of total PAHs were observed in two samples from the tributaries in July 2015 and were 1069ngL-1 and 3141ngL-1 and in September 2015, the highest concentrations were observed in samples collected from Revvatnet lake and were 978ngL-1 and 1823ngL-1. Polycyclic Aromatic Hydrocarbons 42-46 leucine rich repeat containing 4C Homo sapiens 137-142 29227942-6 2018 The highest concentration levels of total PAHs were observed in two samples from the tributaries in July 2015 and were 1069ngL-1 and 3141ngL-1 and in September 2015, the highest concentrations were observed in samples collected from Revvatnet lake and were 978ngL-1 and 1823ngL-1. Polycyclic Aromatic Hydrocarbons 42-46 leucine rich repeat containing 4C Homo sapiens 137-142 29656324-4 2018 However, around the town of Doboj on the Bosna River, concentrations of polycyclic aromatic hydrocarbons (PAH) breached European standards for several compounds and reached 67 ng L-1 for freely dissolved concentrations and 250 ng L-1 for total concentrations. Polycyclic Aromatic Hydrocarbons 72-104 immunoglobulin kappa variable 1-16 Homo sapiens 179-182 29656324-4 2018 However, around the town of Doboj on the Bosna River, concentrations of polycyclic aromatic hydrocarbons (PAH) breached European standards for several compounds and reached 67 ng L-1 for freely dissolved concentrations and 250 ng L-1 for total concentrations. Polycyclic Aromatic Hydrocarbons 72-104 immunoglobulin kappa variable 1-16 Homo sapiens 230-233 29656324-4 2018 However, around the town of Doboj on the Bosna River, concentrations of polycyclic aromatic hydrocarbons (PAH) breached European standards for several compounds and reached 67 ng L-1 for freely dissolved concentrations and 250 ng L-1 for total concentrations. Polycyclic Aromatic Hydrocarbons 106-109 immunoglobulin kappa variable 1-16 Homo sapiens 179-182 29656324-4 2018 However, around the town of Doboj on the Bosna River, concentrations of polycyclic aromatic hydrocarbons (PAH) breached European standards for several compounds and reached 67 ng L-1 for freely dissolved concentrations and 250 ng L-1 for total concentrations. Polycyclic Aromatic Hydrocarbons 106-109 immunoglobulin kappa variable 1-16 Homo sapiens 230-233 29649142-5 2018 Three isomer ratios of PAHs (Phenanthrene/Anthracene, BaA/(BaA+Chy), and LMW/HMW) were used to investigate the potential sources of PAHs, which showed the main source of combustion combined with weaker petroleum contribution. Polycyclic Aromatic Hydrocarbons 132-136 cilia and flagella associated protein 97 Homo sapiens 77-80 29154098-0 2018 Generation and application of a novel transgenic zebrafish line Tg(cyp1a:mCherry) as an in vivo assay to sensitively monitor PAHs and TCDD in the environment. Polycyclic Aromatic Hydrocarbons 125-129 cytochrome P450, family 1, subfamily A Danio rerio 67-72 29154098-4 2018 The results showed that the expressions of mCherry and endogenous cyp1a were consistent with the PAHs exposure concentrations and were largely induced by TCDD and >=4-ring PAHs. Polycyclic Aromatic Hydrocarbons 97-101 cytochrome P450, family 1, subfamily A Danio rerio 66-71 29154098-4 2018 The results showed that the expressions of mCherry and endogenous cyp1a were consistent with the PAHs exposure concentrations and were largely induced by TCDD and >=4-ring PAHs. Polycyclic Aromatic Hydrocarbons 175-179 cytochrome P450, family 1, subfamily A Danio rerio 66-71 29449662-6 2018 The multiplicative-scale interactions between PAHs exposure and polymorphisms of CYP1A2 rs4646425 (P = 0.03) or CYP2E1 rs915908 (P = 0.0238) on the risk of CHDs were observed. Polycyclic Aromatic Hydrocarbons 46-50 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 81-87 29449662-6 2018 The multiplicative-scale interactions between PAHs exposure and polymorphisms of CYP1A2 rs4646425 (P = 0.03) or CYP2E1 rs915908 (P = 0.0238) on the risk of CHDs were observed. Polycyclic Aromatic Hydrocarbons 46-50 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 112-118 29439524-2 2018 This study assessed inhalation exposure to particulate matter (PM1)-bound mercury (Hgp) and PM1-bound polycyclic aromatic hydrocarbons (PAHs) among university students. Polycyclic Aromatic Hydrocarbons 102-134 transmembrane protein 11 Homo sapiens 92-95 29190527-3 2018 OBJECTIVES: To explore potential role of a lung epithelial biomarker, Club cell secretory protein (CC16), in associations between PAH exposures and lung function decline. Polycyclic Aromatic Hydrocarbons 130-133 secretoglobin family 1A member 1 Homo sapiens 99-103 29478645-1 2018 The goal of the work was to investigate the concentrations of the 16 US EPA priority polycyclic aromatic hydrocarbons (PAH) bound to submicrometer particles (particulate matter, PM1) suspended in the air of university teaching rooms and in the atmospheric air outside. Polycyclic Aromatic Hydrocarbons 85-117 transmembrane protein 11 Homo sapiens 178-181 29478645-1 2018 The goal of the work was to investigate the concentrations of the 16 US EPA priority polycyclic aromatic hydrocarbons (PAH) bound to submicrometer particles (particulate matter, PM1) suspended in the air of university teaching rooms and in the atmospheric air outside. Polycyclic Aromatic Hydrocarbons 119-122 transmembrane protein 11 Homo sapiens 178-181 29478645-3 2018 The variabilities of indoor and outdoor 24-hr concentrations of PM1-bound PAH, the ratio (I/O) of the indoor to outdoor 24-hr concentrations of PM1-bound PAH, probable sources of PAH and the level of the hazard from the mixture of the 16 PAH (SigmaPAH) to humans at both sites were analyzed. Polycyclic Aromatic Hydrocarbons 154-157 transmembrane protein 11 Homo sapiens 144-147 29478645-3 2018 The variabilities of indoor and outdoor 24-hr concentrations of PM1-bound PAH, the ratio (I/O) of the indoor to outdoor 24-hr concentrations of PM1-bound PAH, probable sources of PAH and the level of the hazard from the mixture of the 16 PAH (SigmaPAH) to humans at both sites were analyzed. Polycyclic Aromatic Hydrocarbons 154-157 transmembrane protein 11 Homo sapiens 144-147 29478645-3 2018 The variabilities of indoor and outdoor 24-hr concentrations of PM1-bound PAH, the ratio (I/O) of the indoor to outdoor 24-hr concentrations of PM1-bound PAH, probable sources of PAH and the level of the hazard from the mixture of the 16 PAH (SigmaPAH) to humans at both sites were analyzed. Polycyclic Aromatic Hydrocarbons 154-157 transmembrane protein 11 Homo sapiens 144-147 29478645-6 2018 Most probably, the lack of the correlations in Warsaw was due to the existence of an unidentified indoor source of gaseous PAH enriching PM1 in phenanthrene, fluorene, and pyrene. Polycyclic Aromatic Hydrocarbons 123-126 transmembrane protein 11 Homo sapiens 137-140 29478645-7 2018 Although the ambient concentrations of PM1-bound PAH were low compared to the ones observed earlier at both sites, they were much higher than in other urbanized European areas. Polycyclic Aromatic Hydrocarbons 49-52 transmembrane protein 11 Homo sapiens 39-42 29475030-3 2018 PAH adducts to plasma proteins are applied as sensitive biomarkers of PAH exposure in humans and other species, thus the presence of PAH protein adducts in Atlantic cod plasma was investigated to identify PAH protein adduct biomarker candidates of exposure to PAHs. Polycyclic Aromatic Hydrocarbons 260-264 phenylalanine hydroxylase Homo sapiens 0-3 29547867-6 2018 The ecological risk assessment revealed that only sub-location AOC-4 contains PAH to a level of insignificant biological impairment while sub-locations AOC-1, AOC-2 and AOC-6 contain PAHs that pose the highest ecological risks. Polycyclic Aromatic Hydrocarbons 183-187 amine oxidase copper containing 1 Bos taurus 152-157 29547867-6 2018 The ecological risk assessment revealed that only sub-location AOC-4 contains PAH to a level of insignificant biological impairment while sub-locations AOC-1, AOC-2 and AOC-6 contain PAHs that pose the highest ecological risks. Polycyclic Aromatic Hydrocarbons 183-187 amine oxidase copper containing 2 Bos taurus 159-164 29486658-4 2018 The mean dietary exposure to PAHs was estimated at the levels of 5.4 ng BaP/kg bw/day and 36 ng PAH4/kg bw/day. Polycyclic Aromatic Hydrocarbons 29-33 prohibitin 2 Homo sapiens 72-75 28648140-2 2018 1-Chloropyrene, one of the major chlorinated polycyclic aromatic hydrocarbon contaminants, was incubated with human cytochrome P450 (P450 or CYP) enzymes including CYP1A1, 1A2, 1B1, 2A6, 2A13, 2B6, 2C9, 2D6, 2E1, 3A4 and 3A5. Polycyclic Aromatic Hydrocarbons 59-90 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 147-158 29346024-8 2018 The mean concentrations of PAHs in the polluted surface water and hospital wastewater were relatively high: 3.9 +- 1.7 and 21.5 +- 2.8 microg L-1, respectively. Polycyclic Aromatic Hydrocarbons 27-31 L1 cell adhesion molecule Homo sapiens 142-145 29471073-1 2018 Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism. Polycyclic Aromatic Hydrocarbons 0-32 prohibitin 2 Homo sapiens 57-60 29471073-1 2018 Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 73-92 29471073-1 2018 Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-100 29471073-1 2018 Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism. Polycyclic Aromatic Hydrocarbons 0-32 tumor protein p53 Homo sapiens 108-111 29581487-6 2018 Taken together, these results suggest that chronic exposure to environmental PAHs may pose a significant risk for asthma, in which IP, a prominent ambient PAH in Taiwan, was shown to enhance the severity of allergic lung inflammation in mice through, at least in part, its ability in modulating DC"s function in an AhR-dependent manner. Polycyclic Aromatic Hydrocarbons 77-80 aryl-hydrocarbon receptor Mus musculus 315-318 29750188-1 2018 Polycyclic aromatic hydrocarbons like benzo(a)pyrene (BaP) in atmospheric particulate matter pose a threat to human health because of their high carcinogenicity. Polycyclic Aromatic Hydrocarbons 0-32 prohibitin 2 Homo sapiens 54-57 29437390-1 2018 Airborne persistent toxic substances are associated with health impacts resulting from air pollution, for example, dioxins, dioxin-like polychlorinated biphenyls, and certain polycyclic aromatic hydrocarbons (PAHs), which activate aryl hydrocarbon receptors (AhR) and thereby produce adverse outcomes. Polycyclic Aromatic Hydrocarbons 175-207 aryl-hydrocarbon receptor Mus musculus 259-262 29437390-1 2018 Airborne persistent toxic substances are associated with health impacts resulting from air pollution, for example, dioxins, dioxin-like polychlorinated biphenyls, and certain polycyclic aromatic hydrocarbons (PAHs), which activate aryl hydrocarbon receptors (AhR) and thereby produce adverse outcomes. Polycyclic Aromatic Hydrocarbons 209-213 aryl-hydrocarbon receptor Mus musculus 259-262 29170806-8 2018 Significant increases in cyclooxygenase (Cox-2) were observed in response to the B[a]P/LMW PAH mixture combinations. Polycyclic Aromatic Hydrocarbons 91-94 cytochrome c oxidase II, mitochondrial Mus musculus 41-46 29494515-6 2018 Short-term exposure to particulate matter from GDI engine exhaust induced upregulation of genes related to polycyclic aromatic hydrocarbon (PAH) metabolism (Cyp1b1) and inflammation (TNFalpha) in the lungs of non-allergic mice. Polycyclic Aromatic Hydrocarbons 107-138 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 157-163 29494515-6 2018 Short-term exposure to particulate matter from GDI engine exhaust induced upregulation of genes related to polycyclic aromatic hydrocarbon (PAH) metabolism (Cyp1b1) and inflammation (TNFalpha) in the lungs of non-allergic mice. Polycyclic Aromatic Hydrocarbons 140-143 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 157-163 28532657-9 2018 Polycyclic aromatic hydrocarbons, major constituents of DEPs, were implicated in this process through activation of the aryl hydrocarbon receptor and subsequent mitochondrial reactive oxygen species production, which is known to activate transient receptor potential ankyrin-1 on nociceptive C-fibers. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 120-145 29331729-1 2018 Energies of CH/O interactions between water molecule and polycyclic aromatic hydrocarbons with a different number of aromatic rings were calculated using ab initio calculations at MP2/cc-PVTZ level. Polycyclic Aromatic Hydrocarbons 57-89 tryptase pseudogene 1 Homo sapiens 180-183 29203322-5 2018 Here, we assess the effect of in ovo exposure to the model PAH, benzo[k]fluoranthene (BkF), on aryl hydrocarbon receptor (AHR) mediated cytochrome P4501A (CYP1A) gene expression and promoter methylation in chicken embryos. Polycyclic Aromatic Hydrocarbons 59-62 aryl hydrocarbon receptor 1 alpha Gallus gallus 122-125 29203322-10 2018 Characterization of the role of DNA methylation in the AHR response pathway may increase our understanding of the effects of early life exposure to PAHs in birds. Polycyclic Aromatic Hydrocarbons 148-152 aryl hydrocarbon receptor 1 alpha Gallus gallus 55-58 29127633-8 2018 The particle-water partition coefficients (Koc) suggest that the partitioning of PAHs between the particulate and dissolved phases is driven by hydrophobicity and organic matter composition. Polycyclic Aromatic Hydrocarbons 81-85 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 43-46 29128944-7 2018 Results of PAHs showed brands had total PAHs (mg/kg) in the order CFN > CUN > GAA > NGP > FCS > GFC. Polycyclic Aromatic Hydrocarbons 11-15 alpha glucosidase Homo sapiens 84-87 28917749-6 2018 This sensitive analytical method was applied to the determination of trace amounts of PAHs in three natural water samples (river, tap and rainwater) with satisfactory relative recovery values (84-115%), highlighting that the matrices under consideration do not affect the extraction process. Polycyclic Aromatic Hydrocarbons 86-90 nuclear RNA export factor 1 Homo sapiens 130-133 28084139-2 2018 Human cytosolic sulfotransferase 1B1 (SULT1B1) sulfates small phenolic compounds and bioactivates polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 98-130 sulfotransferase family 1B member 1 Homo sapiens 38-45 29111668-1 2017 Benzo[a]pyrene (BaP), an archetypical polycyclic aromatic hydrocarbon, is classified as "carcinogenic to humans" and is ubiquitous in the environment, as evident by the measurable levels of BaP metabolites in virtually all human urine samples examined. Polycyclic Aromatic Hydrocarbons 38-69 prohibitin 2 Homo sapiens 16-19 28632937-1 2017 Cytochromes P450 family 1 (CYP1) are responsible for the metabolism of procarcinogens, for example polycyclic aromatic hydrocarbons and aromatic and heterocyclic amines. Polycyclic Aromatic Hydrocarbons 99-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-25 28632937-1 2017 Cytochromes P450 family 1 (CYP1) are responsible for the metabolism of procarcinogens, for example polycyclic aromatic hydrocarbons and aromatic and heterocyclic amines. Polycyclic Aromatic Hydrocarbons 99-131 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 27-31 29039508-2 2017 The primary concern for the hazardous effect of PAHs is their ability to activate the pathway linked to the aryl hydrocarbon receptor (AhR) and lead to carcinogenesis. Polycyclic Aromatic Hydrocarbons 48-52 aryl-hydrocarbon receptor Mus musculus 108-133 29039508-2 2017 The primary concern for the hazardous effect of PAHs is their ability to activate the pathway linked to the aryl hydrocarbon receptor (AhR) and lead to carcinogenesis. Polycyclic Aromatic Hydrocarbons 48-52 aryl-hydrocarbon receptor Mus musculus 135-138 29176859-6 2017 The results show that, compared to NM, the WC+HECA reduced in-cabin PM2.5 and UFP concentrations, by 37% and 47% respectively (p < 0.05), whereas the reductions on PAH exposures were insignificant. Polycyclic Aromatic Hydrocarbons 167-170 hdc homolog, cell cycle regulator Homo sapiens 46-50 29026953-5 2017 The MIP method allowed PAH recovery levels as high as those measured with the GPC method to be obtained. Polycyclic Aromatic Hydrocarbons 23-26 major intrinsic protein of lens fiber Homo sapiens 4-7 29027804-2 2017 During this research, a series of sigma5-oxaphosphoranes incorporating polycyclic aromatic hydrocarbons (PAHs) were obtained. Polycyclic Aromatic Hydrocarbons 71-103 adaptor related protein complex 5 subunit sigma 1 Homo sapiens 34-40 29027804-2 2017 During this research, a series of sigma5-oxaphosphoranes incorporating polycyclic aromatic hydrocarbons (PAHs) were obtained. Polycyclic Aromatic Hydrocarbons 105-109 adaptor related protein complex 5 subunit sigma 1 Homo sapiens 34-40 29026953-8 2017 Moreover, the PAH concentrations in the MIP operation blank were generally lower than those of GPC operation blanks. Polycyclic Aromatic Hydrocarbons 14-17 major intrinsic protein of lens fiber Homo sapiens 40-43 29026953-9 2017 These results indicated that MIP could be applied to the analysis of PAHs in various lipid matrix-based biological samples. Polycyclic Aromatic Hydrocarbons 69-73 major intrinsic protein of lens fiber Homo sapiens 29-32 29089568-3 2017 Here, we used AFM imaging and NMR, fluorescence, and mass spectrometry to monitor in vitro how Abeta aggregation is affected by the cigarette-related compounds nicotine, polycyclic aromatic hydrocarbons (PAHs) with one to five aromatic rings, and the metal ions Cd(II), Cr(III), Pb(II), and Pb(IV). Polycyclic Aromatic Hydrocarbons 170-202 amyloid beta precursor protein Homo sapiens 95-100 28675851-2 2017 Sequential addition of co-substrate (acetate) and electron acceptor (NO3-) in a two-phase treatment was capable of effectively removing polycyclic aromatic hydrocarbons (PAHs) in river sediment. Polycyclic Aromatic Hydrocarbons 136-168 NBL1, DAN family BMP antagonist Homo sapiens 69-72 28675851-2 2017 Sequential addition of co-substrate (acetate) and electron acceptor (NO3-) in a two-phase treatment was capable of effectively removing polycyclic aromatic hydrocarbons (PAHs) in river sediment. Polycyclic Aromatic Hydrocarbons 170-174 NBL1, DAN family BMP antagonist Homo sapiens 69-72 28884369-0 2017 Carbon Nanotube Fiber Ionization Mass Spectrometry: A Fundamental Study of a Multi-Walled Carbon Nanotube Functionalized Corona Discharge Pin for Polycyclic Aromatic Hydrocarbons Analysis. Polycyclic Aromatic Hydrocarbons 146-178 dynein light chain LC8-type 1 Homo sapiens 138-141 28884369-6 2017 Quantitative work with the nanoCFI source with a designed corona discharge pin insert demonstrated linearity up to 0.97 (R2) of three target PAHs with phenanthrene internal standard. Polycyclic Aromatic Hydrocarbons 141-145 dynein light chain LC8-type 1 Homo sapiens 75-78 29089568-3 2017 Here, we used AFM imaging and NMR, fluorescence, and mass spectrometry to monitor in vitro how Abeta aggregation is affected by the cigarette-related compounds nicotine, polycyclic aromatic hydrocarbons (PAHs) with one to five aromatic rings, and the metal ions Cd(II), Cr(III), Pb(II), and Pb(IV). Polycyclic Aromatic Hydrocarbons 204-208 amyloid beta precursor protein Homo sapiens 95-100 28710019-0 2017 Effects of human blood levels of two PAH mixtures on the AHR signalling activation pathway and CYP1A1 and COMT target genes in granulosa non-tumor and granulosa tumor cell lines. Polycyclic Aromatic Hydrocarbons 37-40 aryl hydrocarbon receptor Homo sapiens 57-60 28651318-3 2017 The total concentrations of seven dissolved PAHs in surface water ranged from 1.0 to 5.1 ng L-1, decreasing with increasing latitude. Polycyclic Aromatic Hydrocarbons 44-48 immunoglobulin kappa variable 1-16 Homo sapiens 92-95 28801749-2 2017 Published monitoring data of polycyclic aromatic hydrocarbons present in soils and sediments at different study points across India were collected and converted to their corresponding BaP equivalent concentrations. Polycyclic Aromatic Hydrocarbons 29-61 prohibitin 2 Homo sapiens 184-187 28322972-1 2017 Cytochrome P450 1B1 (CYP1B1), a member of CYP superfamily, is expressed in liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including metabolic activation of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 192-224 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 0-19 28322972-1 2017 Cytochrome P450 1B1 (CYP1B1), a member of CYP superfamily, is expressed in liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including metabolic activation of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 192-224 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 28629854-5 2017 OAT3 activity was further demonstrated to be blocked by some single chemicals present in cigarette smoke such as the heterocyclic amines AalphaC (IC50=11.3muM) and PhIP (IC50=1.9muM), whereas other major cigarette smoke components used at 100muM, like nicotine, the nitrosamine NNK and the polycyclic aromatic hydrocarbons benzo(a)pyrene and phenanthrene, were without effect. Polycyclic Aromatic Hydrocarbons 290-322 solute carrier family 22 member 8 Homo sapiens 0-4 28482256-2 2017 The chemical analysis revealed the higher accumulation efficiency of polycyclic aromatic hydrocarbons (PAHs) in the finer submicron PMs, and 77.0% of particulate PAHs in PM1 were associated with PM0.4. Polycyclic Aromatic Hydrocarbons 162-166 transmembrane protein 11 Homo sapiens 170-173 28482256-3 2017 Moreover, the BaP equivalent concentrations (BaPeq) were evaluated for size-fractionated submicron PMs, indicating that 77.2% of carcinogenicity of particulate PAHs in PM1 were associated with PM0.4. Polycyclic Aromatic Hydrocarbons 160-164 transmembrane protein 11 Homo sapiens 168-171 28482256-5 2017 The results also suggested that 82.4% of PM1-induced oxidative stress were associated with PM0.4, and the intracellular oxidative stress was significantly correlated with the particulate PAHs. Polycyclic Aromatic Hydrocarbons 187-191 transmembrane protein 11 Homo sapiens 41-44 28500931-3 2017 An interquartile change in urinary PAH metabolite was associated with significant decrements in FEV1 and FVC for eight PAHs, 2-hydroxynapthalene, 1-, and 2-hydroxyphenanthrene, 2-, 3-, and 9-hydroxyfluorene and 3- and 4-hydroxyphenanthrene. Polycyclic Aromatic Hydrocarbons 119-123 phenylalanine hydroxylase Homo sapiens 35-38 28710019-0 2017 Effects of human blood levels of two PAH mixtures on the AHR signalling activation pathway and CYP1A1 and COMT target genes in granulosa non-tumor and granulosa tumor cell lines. Polycyclic Aromatic Hydrocarbons 37-40 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 95-101 28556602-4 2017 These aryl-type radical additions to conjugated hydrocarbons via resonantly stabilized free-radical intermediates defy conventional wisdom that PAH growth is predominantly a high-temperature phenomenon and thus may represent an overlooked path to PAHs as complex as coronene and corannulene in cold regions of the interstellar medium like in the Taurus Molecular Cloud. Polycyclic Aromatic Hydrocarbons 247-251 phenylalanine hydroxylase Homo sapiens 144-147 28461126-1 2017 Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 211-236 28461126-1 2017 Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 238-241 28461126-1 2017 Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 286-311 28461126-1 2017 Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 211-236 28461126-1 2017 Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 238-241 28461126-1 2017 Polycyclic aromatic hydrocarbons (PAHs), such as benzo[a]pyrene (B[a]P), are widely distributed environmental contaminants exerting toxic effects such as genotoxicity and carcinogenicity, mainly associated with aryl hydrocarbon receptor (AhR) activation and the subsequent induction of cytochromes P-450 (CYP) 1-metabolizing enzymes. Polycyclic Aromatic Hydrocarbons 34-38 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 286-311 28407501-6 2017 In animals fed the PAH contaminated diet, we observed down-regulation of expression for innate immune system genes in pathways (p<0.05) for the terminal steps of the complement cascade (complement component C6) and other bacteriolytic processes (lysozyme type II) potentially underlying increased disease susceptibility after pathogen challenge. Polycyclic Aromatic Hydrocarbons 19-22 lysozyme C II Oncorhynchus mykiss 249-265 28634910-1 2017 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor best known for its ability to mediate the effects of environmental toxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin), polycyclic aromatic hydrocarbons (PAHs), benzene, and polychlorinated biphenyls (PCBs) through the initiation of transcription of a number of metabolically active enzymes. Polycyclic Aromatic Hydrocarbons 215-247 aryl-hydrocarbon receptor Mus musculus 4-29 28634910-1 2017 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor best known for its ability to mediate the effects of environmental toxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin), polycyclic aromatic hydrocarbons (PAHs), benzene, and polychlorinated biphenyls (PCBs) through the initiation of transcription of a number of metabolically active enzymes. Polycyclic Aromatic Hydrocarbons 215-247 aryl-hydrocarbon receptor Mus musculus 31-34 28634910-1 2017 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor best known for its ability to mediate the effects of environmental toxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin), polycyclic aromatic hydrocarbons (PAHs), benzene, and polychlorinated biphenyls (PCBs) through the initiation of transcription of a number of metabolically active enzymes. Polycyclic Aromatic Hydrocarbons 249-253 aryl-hydrocarbon receptor Mus musculus 4-29 28634910-1 2017 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor best known for its ability to mediate the effects of environmental toxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin), polycyclic aromatic hydrocarbons (PAHs), benzene, and polychlorinated biphenyls (PCBs) through the initiation of transcription of a number of metabolically active enzymes. Polycyclic Aromatic Hydrocarbons 249-253 aryl-hydrocarbon receptor Mus musculus 31-34 27943120-7 2017 This review provides information about the occurrence of the polycyclic aromatic hydrocarbons (PAHs) and their influence on human exposure and biological effects, including PAH-derived DNA adduct formation and repair processes. Polycyclic Aromatic Hydrocarbons 61-93 phenylalanine hydroxylase Homo sapiens 95-98 28544442-4 2017 Ru(bpy)3 Cl2 absorbs the visible light and transfers the energy to polycyclic aromatic hydrocarbons that enable the redox reactions. Polycyclic Aromatic Hydrocarbons 67-99 endogenous retrovirus group W member 5 Homo sapiens 9-12 28508231-2 2017 Other toxic compounds including some polynuclear aromatic hydrocarbons act through the AhR; however, during the last 25 years, it has become apparent that the AhR plays an essential role in maintaining cellular homeostasis. Polycyclic Aromatic Hydrocarbons 37-70 aryl hydrocarbon receptor Homo sapiens 87-90 28508231-2 2017 Other toxic compounds including some polynuclear aromatic hydrocarbons act through the AhR; however, during the last 25 years, it has become apparent that the AhR plays an essential role in maintaining cellular homeostasis. Polycyclic Aromatic Hydrocarbons 37-70 aryl hydrocarbon receptor Homo sapiens 159-162 28526404-0 2017 Airborne polycyclic aromatic hydrocarbons trigger human skin cells aging through aryl hydrocarbon receptor. Polycyclic Aromatic Hydrocarbons 9-41 aryl hydrocarbon receptor Homo sapiens 81-106 28340461-0 2017 Tracing biomarker of PAH-exposure and susceptibility factor (GSTM-polymorphism) among cancer patients in Pakistan. Polycyclic Aromatic Hydrocarbons 21-24 glutathione S-transferase mu 2 Homo sapiens 61-65 28600683-9 2017 PAH concentrations in both the Jukskei and Klip Rivers were significantly higher than the PCB concentrations. Polycyclic Aromatic Hydrocarbons 0-3 TNFAIP3 interacting protein 2 Homo sapiens 43-47 28600683-11 2017 Both the Jukskei and Klip River sediments showed trends of a mixed pyrogenic-petrogenic PAH source contamination. Polycyclic Aromatic Hydrocarbons 88-91 TNFAIP3 interacting protein 2 Homo sapiens 21-25 28285017-3 2017 PAH induced AHR activation may also lead to adverse effects by modulating other pathways, for example estrogen receptor (ER) signaling in the female reproductive tract. Polycyclic Aromatic Hydrocarbons 0-3 aryl hydrocarbon receptor Rattus norvegicus 12-15 28285017-3 2017 PAH induced AHR activation may also lead to adverse effects by modulating other pathways, for example estrogen receptor (ER) signaling in the female reproductive tract. Polycyclic Aromatic Hydrocarbons 0-3 estrogen receptor 1 Rattus norvegicus 102-119 28285017-3 2017 PAH induced AHR activation may also lead to adverse effects by modulating other pathways, for example estrogen receptor (ER) signaling in the female reproductive tract. Polycyclic Aromatic Hydrocarbons 0-3 estrogen receptor 1 Rattus norvegicus 121-123 27993531-7 2017 CONCLUSIONS: Apart from the well-known induction of CYP1A2 activity by polycyclic aromatic hydrocarbons, smoking might exert an effect on other CYP isoenzymes as well. Polycyclic Aromatic Hydrocarbons 71-103 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 52-58 28384415-1 2017 The marked induction of cytochromes P450 such as CYP1A1 caused by polycyclic aromatic hydrocarbons (PAHs) like 3-methylcholanthrene (MC) is often accompanied by suppression of other hepatic P450s. Polycyclic Aromatic Hydrocarbons 66-98 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 36-40 28607424-10 2017 This may be taken in consideration when beta2-agonists/antagonists are administered in patients exposed to important concentrations of PAHs, e.g. in cigarette smokers. Polycyclic Aromatic Hydrocarbons 135-139 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 40-45 28384415-1 2017 The marked induction of cytochromes P450 such as CYP1A1 caused by polycyclic aromatic hydrocarbons (PAHs) like 3-methylcholanthrene (MC) is often accompanied by suppression of other hepatic P450s. Polycyclic Aromatic Hydrocarbons 66-98 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 28384415-1 2017 The marked induction of cytochromes P450 such as CYP1A1 caused by polycyclic aromatic hydrocarbons (PAHs) like 3-methylcholanthrene (MC) is often accompanied by suppression of other hepatic P450s. Polycyclic Aromatic Hydrocarbons 100-104 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 36-40 28384415-1 2017 The marked induction of cytochromes P450 such as CYP1A1 caused by polycyclic aromatic hydrocarbons (PAHs) like 3-methylcholanthrene (MC) is often accompanied by suppression of other hepatic P450s. Polycyclic Aromatic Hydrocarbons 100-104 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 49-55 28359976-0 2017 TRIM36 hypermethylation is involved in polycyclic aromatic hydrocarbons-induced cell transformation. Polycyclic Aromatic Hydrocarbons 39-71 tripartite motif containing 36 Homo sapiens 0-6 28359976-11 2017 These findings suggest that aberrant hypermethylation of TRIM36 might be involved in the acquisition of malignant phenotype and could be served as a biomarker for risk assessment of PAHs exposure. Polycyclic Aromatic Hydrocarbons 182-186 tripartite motif containing 36 Homo sapiens 57-63 28351761-1 2017 Exposure to environmental aryl hydrocarbon receptor (AhR) agonists, such as halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons (PAHs), has great impacts on the development of various lung diseases. Polycyclic Aromatic Hydrocarbons 114-146 aryl hydrocarbon receptor Homo sapiens 26-51 28351761-1 2017 Exposure to environmental aryl hydrocarbon receptor (AhR) agonists, such as halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons (PAHs), has great impacts on the development of various lung diseases. Polycyclic Aromatic Hydrocarbons 114-146 aryl hydrocarbon receptor Homo sapiens 53-56 28351761-1 2017 Exposure to environmental aryl hydrocarbon receptor (AhR) agonists, such as halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons (PAHs), has great impacts on the development of various lung diseases. Polycyclic Aromatic Hydrocarbons 148-152 aryl hydrocarbon receptor Homo sapiens 26-51 28351761-1 2017 Exposure to environmental aryl hydrocarbon receptor (AhR) agonists, such as halogenated aromatic hydrocarbons and polycyclic aromatic hydrocarbons (PAHs), has great impacts on the development of various lung diseases. Polycyclic Aromatic Hydrocarbons 148-152 aryl hydrocarbon receptor Homo sapiens 53-56 28306249-5 2017 Some PAH metabolites showed consistent positive associations with the plasma inflammation marker C-reactive protein (CRP) and the urinary oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane. Polycyclic Aromatic Hydrocarbons 5-8 C-reactive protein Homo sapiens 97-115 28426525-6 2017 CONCLUSIONS: GSTT1 and GSTM1 may modulate DNA damage levels of p53 gene when exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 88-120 glutathione S-transferase theta 1 Homo sapiens 13-18 28426525-6 2017 CONCLUSIONS: GSTT1 and GSTM1 may modulate DNA damage levels of p53 gene when exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 88-120 glutathione S-transferase mu 1 Homo sapiens 23-28 28426525-6 2017 CONCLUSIONS: GSTT1 and GSTM1 may modulate DNA damage levels of p53 gene when exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 88-120 tumor protein p53 Homo sapiens 63-66 29965078-4 2017 The dominant compounds were low rings PAHs, such as Phe, Nap, Pyr, Fla, Flu and Ant. Polycyclic Aromatic Hydrocarbons 38-42 solute carrier family 25 member 6 Homo sapiens 80-83 28476168-3 2017 Dioxins, related planar polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs) are environmental contaminants that activate the aryl hydrocarbon receptor (AHR), a ligand-activated, PAS family transcription factor. Polycyclic Aromatic Hydrocarbons 62-94 aryl-hydrocarbon receptor Mus musculus 151-176 28476168-3 2017 Dioxins, related planar polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs) are environmental contaminants that activate the aryl hydrocarbon receptor (AHR), a ligand-activated, PAS family transcription factor. Polycyclic Aromatic Hydrocarbons 62-94 aryl-hydrocarbon receptor Mus musculus 178-181 28476168-3 2017 Dioxins, related planar polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs) are environmental contaminants that activate the aryl hydrocarbon receptor (AHR), a ligand-activated, PAS family transcription factor. Polycyclic Aromatic Hydrocarbons 96-100 aryl-hydrocarbon receptor Mus musculus 151-176 28476168-3 2017 Dioxins, related planar polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs) are environmental contaminants that activate the aryl hydrocarbon receptor (AHR), a ligand-activated, PAS family transcription factor. Polycyclic Aromatic Hydrocarbons 96-100 aryl-hydrocarbon receptor Mus musculus 178-181 28282619-1 2017 Previous studies in our lab have revealed that both P-glycoprotein (Pgp) and multi-resistance associated protein (Mrp) 1 played important roles in the detoxification of heavy metals and polycyclic aromatic hydrocarbon (PAH) in zebrafish embryos. Polycyclic Aromatic Hydrocarbons 186-217 phosphoglycolate phosphatase Danio rerio 52-66 28282619-1 2017 Previous studies in our lab have revealed that both P-glycoprotein (Pgp) and multi-resistance associated protein (Mrp) 1 played important roles in the detoxification of heavy metals and polycyclic aromatic hydrocarbon (PAH) in zebrafish embryos. Polycyclic Aromatic Hydrocarbons 186-217 phosphoglycolate phosphatase Danio rerio 68-71 28282619-1 2017 Previous studies in our lab have revealed that both P-glycoprotein (Pgp) and multi-resistance associated protein (Mrp) 1 played important roles in the detoxification of heavy metals and polycyclic aromatic hydrocarbon (PAH) in zebrafish embryos. Polycyclic Aromatic Hydrocarbons 219-222 phosphoglycolate phosphatase Danio rerio 52-66 28282619-1 2017 Previous studies in our lab have revealed that both P-glycoprotein (Pgp) and multi-resistance associated protein (Mrp) 1 played important roles in the detoxification of heavy metals and polycyclic aromatic hydrocarbon (PAH) in zebrafish embryos. Polycyclic Aromatic Hydrocarbons 219-222 phosphoglycolate phosphatase Danio rerio 68-71 28236708-9 2017 High PAH levels detected in infant formula enriched with LC-PUFA might be related to the contamination of the vegetable oils added as ingredients. Polycyclic Aromatic Hydrocarbons 5-8 pumilio RNA binding family member 3 Homo sapiens 60-64 28481916-3 2017 Here we investigate the hypothesis that TCF21 interacts with a downstream target gene, the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that mediates the cellular response to environmental contaminants, including dioxin and polycyclic aromatic hydrocarbons (e.g., tobacco smoke). Polycyclic Aromatic Hydrocarbons 252-284 transcription factor 21 Homo sapiens 40-45 28481916-3 2017 Here we investigate the hypothesis that TCF21 interacts with a downstream target gene, the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that mediates the cellular response to environmental contaminants, including dioxin and polycyclic aromatic hydrocarbons (e.g., tobacco smoke). Polycyclic Aromatic Hydrocarbons 252-284 aryl hydrocarbon receptor Homo sapiens 118-121 27980293-2 2017 AHR was originally thought to be involved in not only drug metabolism but also carcinogenic and toxicological responses against environmental contaminants, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 211-243 aryl hydrocarbon receptor Homo sapiens 0-3 27830268-2 2017 In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells. Polycyclic Aromatic Hydrocarbons 179-210 histone deacetylase 9 Homo sapiens 50-69 27830268-2 2017 In this study, we investigated the impact of this histone deacetylase (HDAC) inhibitor on expression/activity of cytochrome P450 family 1 (CYP1) and on metabolism of carcinogenic polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP), in colon epithelial cells. Polycyclic Aromatic Hydrocarbons 179-210 histone deacetylase 9 Homo sapiens 71-75 28160681-5 2017 In the presence of H2O2 at a dose of 20 muM, Fenton-driven chemical oxidation appeared to outplay the impediment of biodegradation caused by inhibited microbial activities in terms of removing total polycyclic aromatic hydrocarbons from the water column. Polycyclic Aromatic Hydrocarbons 199-231 latexin Homo sapiens 40-43 28329830-4 2017 Both 1-MeA, Flthn, and the binary PAH mixture of 1-MeA and Flthn dysregulated GJIC in a dose and time-dependent manner, reduced Cx43 protein, and activated the following MAPKs: P38, ERK1/2, and JNK. Polycyclic Aromatic Hydrocarbons 34-37 gap junction protein alpha 1 Homo sapiens 128-132 28329830-4 2017 Both 1-MeA, Flthn, and the binary PAH mixture of 1-MeA and Flthn dysregulated GJIC in a dose and time-dependent manner, reduced Cx43 protein, and activated the following MAPKs: P38, ERK1/2, and JNK. Polycyclic Aromatic Hydrocarbons 34-37 mitogen-activated protein kinase 1 Homo sapiens 177-180 28329830-4 2017 Both 1-MeA, Flthn, and the binary PAH mixture of 1-MeA and Flthn dysregulated GJIC in a dose and time-dependent manner, reduced Cx43 protein, and activated the following MAPKs: P38, ERK1/2, and JNK. Polycyclic Aromatic Hydrocarbons 34-37 mitogen-activated protein kinase 3 Homo sapiens 182-188 28329830-4 2017 Both 1-MeA, Flthn, and the binary PAH mixture of 1-MeA and Flthn dysregulated GJIC in a dose and time-dependent manner, reduced Cx43 protein, and activated the following MAPKs: P38, ERK1/2, and JNK. Polycyclic Aromatic Hydrocarbons 34-37 mitogen-activated protein kinase 8 Homo sapiens 194-197 28351644-13 2017 The prepared sol-gel CME coatings provided low ng L-1 limit of detections (LOD) (4.2-26.3 ng L-1) for environmentally important analytes including polycyclic aromatic hydrocarbons, ketones and aliphatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 147-179 immunoglobulin kappa variable 1-16 Homo sapiens 50-53 28306249-5 2017 Some PAH metabolites showed consistent positive associations with the plasma inflammation marker C-reactive protein (CRP) and the urinary oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane. Polycyclic Aromatic Hydrocarbons 5-8 C-reactive protein Homo sapiens 117-120 28108015-0 2017 Seasonal variation of polycyclic aromatic hydrocarbons in the surface sediments of the southern Caspian Sea. Polycyclic Aromatic Hydrocarbons 22-54 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 0-3 28213827-7 2017 Following exposures to simple and complex PAH mixtures, Rep killifish exhibited several phenotypes associated with PAH resistance including decreased incidences of developmental cardiovascular deformities and recalcitrant cytochrome P450 1A (CYP1A) activity. Polycyclic Aromatic Hydrocarbons 42-45 cytochrome P450 1A1 Fundulus heteroclitus 222-240 28213827-7 2017 Following exposures to simple and complex PAH mixtures, Rep killifish exhibited several phenotypes associated with PAH resistance including decreased incidences of developmental cardiovascular deformities and recalcitrant cytochrome P450 1A (CYP1A) activity. Polycyclic Aromatic Hydrocarbons 42-45 cytochrome P450 1A1 Fundulus heteroclitus 242-247 28213827-7 2017 Following exposures to simple and complex PAH mixtures, Rep killifish exhibited several phenotypes associated with PAH resistance including decreased incidences of developmental cardiovascular deformities and recalcitrant cytochrome P450 1A (CYP1A) activity. Polycyclic Aromatic Hydrocarbons 115-118 cytochrome P450 1A1 Fundulus heteroclitus 242-247 28342081-6 2017 PAH patterns and diagnostic ratios indicated that biomass burning may be also an important source of PAHs in the surrounding soil in addition to the emissions from the plants investigated. Polycyclic Aromatic Hydrocarbons 101-105 phenylalanine hydroxylase Homo sapiens 0-3 26300350-3 2017 The total concentrations of PBDEs, OCPs, and PAHs varied from 5.2 to 12.3 pg L-1, from 29.1 to 96.4 ng L-1, and from 28.6 to 48.5 ng L-1, respectively. Polycyclic Aromatic Hydrocarbons 45-49 immunoglobulin kappa variable 1-16 Homo sapiens 77-80 26300350-5 2017 A source analysis showed that PBDEs may come from the flame retardant usages of penta-BDE and deca-BDE; hexachlorocyclohexane isomers (HCHs) were from the use of technical HCHs, while DDTs were attributed to early residuals of industrial sources, and PAHs were mainly from pyrolytic sources. Polycyclic Aromatic Hydrocarbons 251-255 homeobox D13 Homo sapiens 31-34 27068894-4 2017 Nearly 75 % of the total polycyclic aromatic hydrocarbon (PAH) pool was represented by high molecular four-to-six-ring compounds, deriving mainly from combustion sources. Polycyclic Aromatic Hydrocarbons 25-56 phenylalanine hydroxylase Homo sapiens 58-61 28391951-1 2017 n-Alkanes and polycyclic aromatic hydrocarbons (PAHs) bound to atmospheric particulate matter (PM1) were investigated in a traffic site located in an urban area of Venice Province (Eastern Po Valley, Italy) during the cold season. Polycyclic Aromatic Hydrocarbons 14-46 transmembrane protein 11 Homo sapiens 95-98 28391951-0 2017 Source apportionment of PAHs and n-alkanes bound to PM1 collected near the Venice highway. Polycyclic Aromatic Hydrocarbons 24-28 transmembrane protein 11 Homo sapiens 52-55 28391951-1 2017 n-Alkanes and polycyclic aromatic hydrocarbons (PAHs) bound to atmospheric particulate matter (PM1) were investigated in a traffic site located in an urban area of Venice Province (Eastern Po Valley, Italy) during the cold season. Polycyclic Aromatic Hydrocarbons 48-52 transmembrane protein 11 Homo sapiens 95-98 28104439-0 2017 Up-regulation of CYP1A1 and phase II enzymes by 5-ring isomeric polycyclic aromatic hydrocarbons in precision-cut rat hepatic slices: Importance of molecular shape. Polycyclic Aromatic Hydrocarbons 64-96 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 17-23 28104439-1 2017 The objectives of the present study were two-fold: (a) to evaluate the role of molecular shape on the interaction of polycyclic aromatic hydrocarbons (PAHs) with the Ah receptor and CYP1A1 upregulation, and (b) to evaluate the potential of PAHs to induce epoxide hydrolase and glutathione S-transferase, two major enzymes involved in their metabolism. Polycyclic Aromatic Hydrocarbons 117-149 aryl hydrocarbon receptor Rattus norvegicus 166-177 28104439-1 2017 The objectives of the present study were two-fold: (a) to evaluate the role of molecular shape on the interaction of polycyclic aromatic hydrocarbons (PAHs) with the Ah receptor and CYP1A1 upregulation, and (b) to evaluate the potential of PAHs to induce epoxide hydrolase and glutathione S-transferase, two major enzymes involved in their metabolism. Polycyclic Aromatic Hydrocarbons 151-155 aryl hydrocarbon receptor Rattus norvegicus 166-177 28104439-1 2017 The objectives of the present study were two-fold: (a) to evaluate the role of molecular shape on the interaction of polycyclic aromatic hydrocarbons (PAHs) with the Ah receptor and CYP1A1 upregulation, and (b) to evaluate the potential of PAHs to induce epoxide hydrolase and glutathione S-transferase, two major enzymes involved in their metabolism. Polycyclic Aromatic Hydrocarbons 151-155 hematopoietic prostaglandin D synthase Rattus norvegicus 277-302 28104439-5 2017 Of the seven PAHs, only benzo[g]chrysene elevated glutathione S-transferase activity, measured using 1-chloro-2,4-dinitrobenzene or 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole as substrates. Polycyclic Aromatic Hydrocarbons 13-17 hematopoietic prostaglandin D synthase Rattus norvegicus 50-75 28366950-0 2017 Effect of the GSTM1 genotype on the biomarkers of exposure to polycyclic aromatic hydrocarbons: Meta-analysis. Polycyclic Aromatic Hydrocarbons 62-94 glutathione S-transferase mu 1 Homo sapiens 14-19 28443179-1 2017 A variety of xenobiotic chemicals, such as polycyclic aromatic hydrocarbons (PAHs), aryl- and heterocyclic amines and tobacco related nitrosamines, are ubiquitous environmental carcinogens and are required to be activated to chemically reactive metabolites by xenobiotic-metabolizing enzymes, including cytochrome P450 (P450 or CYP), in order to initiate cell transformation. Polycyclic Aromatic Hydrocarbons 43-75 uncharacterized protein LOC107819388 Nicotiana tabacum 303-318 28443179-1 2017 A variety of xenobiotic chemicals, such as polycyclic aromatic hydrocarbons (PAHs), aryl- and heterocyclic amines and tobacco related nitrosamines, are ubiquitous environmental carcinogens and are required to be activated to chemically reactive metabolites by xenobiotic-metabolizing enzymes, including cytochrome P450 (P450 or CYP), in order to initiate cell transformation. Polycyclic Aromatic Hydrocarbons 77-81 uncharacterized protein LOC107819388 Nicotiana tabacum 303-318 28366950-1 2017 The role of glutathione S-transferase Mu 1 (GSTM1) in the biomonitoring of polycyclic aromatic hydrocarbons (PAHs) is not clear. Polycyclic Aromatic Hydrocarbons 75-107 glutathione S-transferase mu 1 Homo sapiens 44-49 28366950-1 2017 The role of glutathione S-transferase Mu 1 (GSTM1) in the biomonitoring of polycyclic aromatic hydrocarbons (PAHs) is not clear. Polycyclic Aromatic Hydrocarbons 109-113 glutathione S-transferase mu 1 Homo sapiens 44-49 27925506-0 2017 Aliphatic and polycyclic aromatic hydrocarbons (PAHs) in soils of the northwest Qinling Mountains: Patterns, potential risk and an appraisal of the PAH ratios to infer their source. Polycyclic Aromatic Hydrocarbons 14-46 phenylalanine hydroxylase Homo sapiens 48-51 27925506-6 2017 Because the photochemical reaction of PAHs in the atmosphere would produce lower ratios for Ant/(Ant + Phe), BaA/(BaA + Chr) and IcdP/(IcdP + BghiP), but a higher ratio for Fla/(Fla + Pyr), the source classification highly depended on the diagnostic ratios chosen. Polycyclic Aromatic Hydrocarbons 38-42 solute carrier family 25 member 6 Homo sapiens 92-95 27925506-6 2017 Because the photochemical reaction of PAHs in the atmosphere would produce lower ratios for Ant/(Ant + Phe), BaA/(BaA + Chr) and IcdP/(IcdP + BghiP), but a higher ratio for Fla/(Fla + Pyr), the source classification highly depended on the diagnostic ratios chosen. Polycyclic Aromatic Hydrocarbons 38-42 solute carrier family 25 member 6 Homo sapiens 97-100 28365671-1 2017 The aim of this cross-sectional study was to see whether genetic polymorphisms of the enzymes CYP1A1, GSTM1, and GSTT1 are associated with higher risk of coronary artery disease (CAD) and whether they affect lipid profile in 252 subjects living near a natural gas plant, who are likely to be exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 303-335 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-100 28327162-11 2017 PAH-coating reduced some effects of P90 such as IL-8 mRNA expression and oxidative stress in A549 cells, granulocyte influx in the in vivo OECD experiment, and agglomeration of P90 and mucus release in the murine trachea ex vivo. Polycyclic Aromatic Hydrocarbons 0-3 chemokine (C-X-C motif) ligand 15 Mus musculus 48-52 28327162-13 2017 In contrast, PAH-coating induced IL-8 mRNA expression in bronchial epithelial cell lines, and Cyp mRNA expression and apoptosis in tracheal epithelial cells. Polycyclic Aromatic Hydrocarbons 13-16 chemokine (C-X-C motif) ligand 15 Mus musculus 33-37 28365671-1 2017 The aim of this cross-sectional study was to see whether genetic polymorphisms of the enzymes CYP1A1, GSTM1, and GSTT1 are associated with higher risk of coronary artery disease (CAD) and whether they affect lipid profile in 252 subjects living near a natural gas plant, who are likely to be exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 303-335 glutathione S-transferase mu 1 Homo sapiens 102-107 28365671-1 2017 The aim of this cross-sectional study was to see whether genetic polymorphisms of the enzymes CYP1A1, GSTM1, and GSTT1 are associated with higher risk of coronary artery disease (CAD) and whether they affect lipid profile in 252 subjects living near a natural gas plant, who are likely to be exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 303-335 glutathione S-transferase theta 1 Homo sapiens 113-118 28365671-1 2017 The aim of this cross-sectional study was to see whether genetic polymorphisms of the enzymes CYP1A1, GSTM1, and GSTT1 are associated with higher risk of coronary artery disease (CAD) and whether they affect lipid profile in 252 subjects living near a natural gas plant, who are likely to be exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 337-341 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-100 28365671-1 2017 The aim of this cross-sectional study was to see whether genetic polymorphisms of the enzymes CYP1A1, GSTM1, and GSTT1 are associated with higher risk of coronary artery disease (CAD) and whether they affect lipid profile in 252 subjects living near a natural gas plant, who are likely to be exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 337-341 glutathione S-transferase mu 1 Homo sapiens 102-107 28365671-1 2017 The aim of this cross-sectional study was to see whether genetic polymorphisms of the enzymes CYP1A1, GSTM1, and GSTT1 are associated with higher risk of coronary artery disease (CAD) and whether they affect lipid profile in 252 subjects living near a natural gas plant, who are likely to be exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 337-341 glutathione S-transferase theta 1 Homo sapiens 113-118 27099206-0 2017 Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision-cut rat liver slices. Polycyclic Aromatic Hydrocarbons 64-96 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 120-124 28065424-3 2017 Biomonitoring of hydroxylated PAH (OH-PAH) metabolites in urine provides an integrated measure of exposure to PAHs via multiple routes and has been used to characterize exposure to PAHs in humans. Polycyclic Aromatic Hydrocarbons 110-114 phenylalanine hydroxylase Homo sapiens 30-33 28065424-3 2017 Biomonitoring of hydroxylated PAH (OH-PAH) metabolites in urine provides an integrated measure of exposure to PAHs via multiple routes and has been used to characterize exposure to PAHs in humans. Polycyclic Aromatic Hydrocarbons 110-114 phenylalanine hydroxylase Homo sapiens 38-41 28065424-3 2017 Biomonitoring of hydroxylated PAH (OH-PAH) metabolites in urine provides an integrated measure of exposure to PAHs via multiple routes and has been used to characterize exposure to PAHs in humans. Polycyclic Aromatic Hydrocarbons 181-185 phenylalanine hydroxylase Homo sapiens 30-33 28065424-3 2017 Biomonitoring of hydroxylated PAH (OH-PAH) metabolites in urine provides an integrated measure of exposure to PAHs via multiple routes and has been used to characterize exposure to PAHs in humans. Polycyclic Aromatic Hydrocarbons 181-185 phenylalanine hydroxylase Homo sapiens 38-41 27283969-5 2017 After 24 h of exposure, all PAHs, except for benzo[a]anthracene, acted as potent inducers of the gene cyp1a1. Polycyclic Aromatic Hydrocarbons 28-32 cytochrome P450, family 1, subfamily A Danio rerio 102-108 28007386-0 2017 Polycyclic aromatic hydrocarbon pollution in the surface water and sediments of Chabahar Bay, Oman Sea. Polycyclic Aromatic Hydrocarbons 0-31 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 99-102 28007386-2 2017 The concentrations of PAHs in the surface water samples ranged from 1.7 to 2.8ngl-1 and from 0.04 to 59.6ngl-1 in pre- and postmonsoon, respectively. Polycyclic Aromatic Hydrocarbons 22-26 leucine rich repeat containing 4C Homo sapiens 78-83 27099206-1 2017 The current studies investigate whether synergistic or antagonistic interactions in the upregulation of CYP1 activity occur in binary mixtures of polycyclic aromatic hydrocarbons (PAHs) involving benzo[a]pyrene and five other structurally diverse PAHs of varying carcinogenic activity. Polycyclic Aromatic Hydrocarbons 146-178 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 104-108 27099206-1 2017 The current studies investigate whether synergistic or antagonistic interactions in the upregulation of CYP1 activity occur in binary mixtures of polycyclic aromatic hydrocarbons (PAHs) involving benzo[a]pyrene and five other structurally diverse PAHs of varying carcinogenic activity. Polycyclic Aromatic Hydrocarbons 180-184 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 104-108 27099206-1 2017 The current studies investigate whether synergistic or antagonistic interactions in the upregulation of CYP1 activity occur in binary mixtures of polycyclic aromatic hydrocarbons (PAHs) involving benzo[a]pyrene and five other structurally diverse PAHs of varying carcinogenic activity. Polycyclic Aromatic Hydrocarbons 247-251 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 104-108 27099206-7 2017 In conclusion, it has been demonstrated that the benzo[a]pyrene-mediated upregulation of CYP1, at the mRNA and activity levels, is synergistically and antagonistically modulated by other PAHs. Polycyclic Aromatic Hydrocarbons 187-191 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 89-93 27806574-3 2017 Although these enzymes play clear cytoprotective roles and deal effectively with carbonyl stress, their upregulation by the Keap1/Nrf2 pathway also has a potential dark-side, which can lead to chemotherapeutic drug resistance and the metabolic activation of lung carcinogens (e.g., polycyclic aromatic hydrocarbons). Polycyclic Aromatic Hydrocarbons 282-314 kelch like ECH associated protein 1 Homo sapiens 124-129 26856715-5 2017 Interestingly, ICZ is a potent activator of the aryl hydrocarbon receptor (AhR), a transcription factor known to mediate toxic effects of environmental pollutants, such as dioxin and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 183-215 aryl hydrocarbon receptor Homo sapiens 48-73 26856715-5 2017 Interestingly, ICZ is a potent activator of the aryl hydrocarbon receptor (AhR), a transcription factor known to mediate toxic effects of environmental pollutants, such as dioxin and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 183-215 aryl hydrocarbon receptor Homo sapiens 75-78 28115713-2 2017 One of the most carcinogenic PAHs, benzo(a)pyrene (BaP), is efficiently bound to and transported with atmospheric particles. Polycyclic Aromatic Hydrocarbons 29-33 prohibitin 2 Homo sapiens 51-54 27816287-5 2017 Based on both the results of a principal component analysis (PCA) and the PAH ratios, the main sources of the PAHs in soils were determined to be the combustion of coal and petroleum. Polycyclic Aromatic Hydrocarbons 110-114 phenylalanine hydroxylase Homo sapiens 74-77 27886549-5 2017 The experiment indicated that P25-2.5%GR exhibited enhancement in both adsorption and photodegradation, ~80% of PAHs were removed after 2h photocatalysis. Polycyclic Aromatic Hydrocarbons 112-116 tubulin polymerization promoting protein Homo sapiens 30-33 27856527-1 2017 The aryl hydrocarbon receptor (AHR) nuclear translocator (ARNT), as the AHR"s heterodimerization partner, and NADPH-cytochrome P450 oxidoreductase (POR), as the key electron donor for all microsomal P450s, are independent and indispensable components in the adaptive and toxic responses to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 290-322 aryl hydrocarbon receptor Homo sapiens 31-34 27856527-1 2017 The aryl hydrocarbon receptor (AHR) nuclear translocator (ARNT), as the AHR"s heterodimerization partner, and NADPH-cytochrome P450 oxidoreductase (POR), as the key electron donor for all microsomal P450s, are independent and indispensable components in the adaptive and toxic responses to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 290-322 aryl hydrocarbon receptor nuclear translocator Homo sapiens 58-62 27856527-1 2017 The aryl hydrocarbon receptor (AHR) nuclear translocator (ARNT), as the AHR"s heterodimerization partner, and NADPH-cytochrome P450 oxidoreductase (POR), as the key electron donor for all microsomal P450s, are independent and indispensable components in the adaptive and toxic responses to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 290-322 aryl hydrocarbon receptor Homo sapiens 72-75 28059605-9 2017 Correlation analysis showed that methylated CpG sites in CTNNA1 and MYH2 from NTD cases were positively correlated to polycyclic aromatic hydrocarbon level in fetal neural tissues and maternal serum. Polycyclic Aromatic Hydrocarbons 118-149 catenin (cadherin associated protein), alpha 1 Mus musculus 57-63 28059605-9 2017 Correlation analysis showed that methylated CpG sites in CTNNA1 and MYH2 from NTD cases were positively correlated to polycyclic aromatic hydrocarbon level in fetal neural tissues and maternal serum. Polycyclic Aromatic Hydrocarbons 118-149 myosin, heavy polypeptide 2, skeletal muscle, adult Mus musculus 68-72 27806574-3 2017 Although these enzymes play clear cytoprotective roles and deal effectively with carbonyl stress, their upregulation by the Keap1/Nrf2 pathway also has a potential dark-side, which can lead to chemotherapeutic drug resistance and the metabolic activation of lung carcinogens (e.g., polycyclic aromatic hydrocarbons). Polycyclic Aromatic Hydrocarbons 282-314 NFE2 like bZIP transcription factor 2 Homo sapiens 130-134 27838061-5 2017 The exposure to PAHs negatively affected estradiol (E2) and Anti-Mullerian hormones (AMH) and positively affected FSH in the umbilical cord serum. Polycyclic Aromatic Hydrocarbons 16-20 anti-Mullerian hormone Homo sapiens 85-88 27692472-1 2016 The Multimedia Urban Model (MUM-Fate) was used to estimate the emissions, fate and transport of polycyclic aromatic hydrocarbons (PAHs) in Tarragona County, Catalonia, Spain, where the largest chemical/petrochemical industrial complex of Southern Europe is located. Polycyclic Aromatic Hydrocarbons 96-128 latexin Homo sapiens 28-31 27692884-0 2017 Assessment of the aryl hydrocarbon receptor-mediated activities of polycyclic aromatic hydrocarbons in a human cell-based reporter gene assay. Polycyclic Aromatic Hydrocarbons 67-99 aryl hydrocarbon receptor Homo sapiens 18-43 27692884-1 2017 Activation of the aryl hydrocarbon receptor (AhR)-mediated activity is one of key events in toxicity of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 104-136 aryl hydrocarbon receptor Homo sapiens 18-43 27692884-1 2017 Activation of the aryl hydrocarbon receptor (AhR)-mediated activity is one of key events in toxicity of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 104-136 aryl hydrocarbon receptor Homo sapiens 45-48 27692884-1 2017 Activation of the aryl hydrocarbon receptor (AhR)-mediated activity is one of key events in toxicity of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 138-142 aryl hydrocarbon receptor Homo sapiens 18-43 27692884-1 2017 Activation of the aryl hydrocarbon receptor (AhR)-mediated activity is one of key events in toxicity of polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 138-142 aryl hydrocarbon receptor Homo sapiens 45-48 27692884-9 2017 The present data suggest that differences may exist between the AhR-mediated potencies of PAHs in human and rodent cells, and that the AhR-mediated effects of polar PAH derivatives and metabolites in human cell models deserve further attention. Polycyclic Aromatic Hydrocarbons 90-94 aryl hydrocarbon receptor Homo sapiens 64-67 27692884-9 2017 The present data suggest that differences may exist between the AhR-mediated potencies of PAHs in human and rodent cells, and that the AhR-mediated effects of polar PAH derivatives and metabolites in human cell models deserve further attention. Polycyclic Aromatic Hydrocarbons 90-93 aryl hydrocarbon receptor Homo sapiens 64-67 27796996-0 2017 Serum adipocyte-fatty acid binding protein (FABP4) levels in women from Mexico exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 90-122 fatty acid binding protein 4 Homo sapiens 6-42 27796996-0 2017 Serum adipocyte-fatty acid binding protein (FABP4) levels in women from Mexico exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 90-122 fatty acid binding protein 4 Homo sapiens 44-49 27796996-0 2017 Serum adipocyte-fatty acid binding protein (FABP4) levels in women from Mexico exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 124-128 fatty acid binding protein 4 Homo sapiens 6-42 27796996-0 2017 Serum adipocyte-fatty acid binding protein (FABP4) levels in women from Mexico exposed to polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 124-128 fatty acid binding protein 4 Homo sapiens 44-49 27692472-1 2016 The Multimedia Urban Model (MUM-Fate) was used to estimate the emissions, fate and transport of polycyclic aromatic hydrocarbons (PAHs) in Tarragona County, Catalonia, Spain, where the largest chemical/petrochemical industrial complex of Southern Europe is located. Polycyclic Aromatic Hydrocarbons 130-134 latexin Homo sapiens 28-31 27565807-8 2016 We observed significant interactions between maternal PAH exposure and SNPs on cord B[ a ]P-DNA adducts in the following genes: maternal CYP1A1 and GSTT2 , and newborn CYP1A1 and CYP1B1 . Polycyclic Aromatic Hydrocarbons 54-57 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 137-143 28250663-14 2017 Abbreviations Used: BRCA1: Breast Cancer Gene 1; BRCA2: Breast Cancer Gene 1; CYP: Cytochrome P450; DMBA: 7,12-Dimethylbenzanthracene; DMSO: Dimethyl sulfoxide; H2O2: Hydrogen peroxides; LPO: Lipid peroxidation; PAH: Polycyclic aromatic hydrocarbon; ROS: Reactive oxygen species; TBARS: Thiobarbituric acid reactive substances; GSSG: Oxidized glutathione. Polycyclic Aromatic Hydrocarbons 212-215 BRCA1, DNA repair associated Rattus norvegicus 20-25 28250663-14 2017 Abbreviations Used: BRCA1: Breast Cancer Gene 1; BRCA2: Breast Cancer Gene 1; CYP: Cytochrome P450; DMBA: 7,12-Dimethylbenzanthracene; DMSO: Dimethyl sulfoxide; H2O2: Hydrogen peroxides; LPO: Lipid peroxidation; PAH: Polycyclic aromatic hydrocarbon; ROS: Reactive oxygen species; TBARS: Thiobarbituric acid reactive substances; GSSG: Oxidized glutathione. Polycyclic Aromatic Hydrocarbons 217-248 BRCA1, DNA repair associated Rattus norvegicus 20-25 29965310-3 2016 Average PAHs concentrations in the effluent of these four facilities, asphalt roofing and blank control facilities were 145, 166, 151, 160, 900, 270 ng L-1, respectively. Polycyclic Aromatic Hydrocarbons 8-12 immunoglobulin kappa variable 1-16 Homo sapiens 152-155 27614039-11 2016 32, 17, 23 and 23 different PAHs and PCBs were detected in AEL, AWL, OSL and NPL respectively, at varying retention peak times. Polycyclic Aromatic Hydrocarbons 28-32 N-acetylneuraminate pyruvate lyase Homo sapiens 77-80 28043265-0 2016 [Effects of genetic polymorphisms of GSTT1 and GSTM1 on metabolism of Polycyclic aromatic hydrocarbon in coal tar pitch workers]. Polycyclic Aromatic Hydrocarbons 70-101 glutathione S-transferase theta 1 Homo sapiens 37-42 28043265-0 2016 [Effects of genetic polymorphisms of GSTT1 and GSTM1 on metabolism of Polycyclic aromatic hydrocarbon in coal tar pitch workers]. Polycyclic Aromatic Hydrocarbons 70-101 glutathione S-transferase mu 1 Homo sapiens 47-52 28043265-1 2016 Objective: To investigate the influence of genetic polymorphisms of GSTT1 and GSTM1 on metabolism of polycyclic aromatic hydrocarbon (PAHs) in coal tar pitch workers and to explore the effective bio-marker of occupational exposure to coal tar pitch. Polycyclic Aromatic Hydrocarbons 101-132 glutathione S-transferase theta 1 Homo sapiens 68-73 28043265-1 2016 Objective: To investigate the influence of genetic polymorphisms of GSTT1 and GSTM1 on metabolism of polycyclic aromatic hydrocarbon (PAHs) in coal tar pitch workers and to explore the effective bio-marker of occupational exposure to coal tar pitch. Polycyclic Aromatic Hydrocarbons 101-132 glutathione S-transferase mu 1 Homo sapiens 78-83 28043265-1 2016 Objective: To investigate the influence of genetic polymorphisms of GSTT1 and GSTM1 on metabolism of polycyclic aromatic hydrocarbon (PAHs) in coal tar pitch workers and to explore the effective bio-marker of occupational exposure to coal tar pitch. Polycyclic Aromatic Hydrocarbons 134-138 glutathione S-transferase theta 1 Homo sapiens 68-73 28043265-1 2016 Objective: To investigate the influence of genetic polymorphisms of GSTT1 and GSTM1 on metabolism of polycyclic aromatic hydrocarbon (PAHs) in coal tar pitch workers and to explore the effective bio-marker of occupational exposure to coal tar pitch. Polycyclic Aromatic Hydrocarbons 134-138 glutathione S-transferase mu 1 Homo sapiens 78-83 28043265-9 2016 Conclusion: Carrying positive GSTT1 and GSTM1 promote polycyclic aromatic hydrocarbons in the body"s metabolism. Polycyclic Aromatic Hydrocarbons 54-86 glutathione S-transferase theta 1 Homo sapiens 30-35 28043265-9 2016 Conclusion: Carrying positive GSTT1 and GSTM1 promote polycyclic aromatic hydrocarbons in the body"s metabolism. Polycyclic Aromatic Hydrocarbons 54-86 glutathione S-transferase mu 1 Homo sapiens 40-45 27424142-3 2016 Among several carcinogenic and teratogenic components of cigarette smoke condensate (CSC), polycyclic aromatic hydrocarbons (PAHs) display a preeminent role in accelerating germ cell death via the cytoplasmic transcription factor, aryl hydrocarbon receptor (AHR) that is present across all stages of spermatogenesis. Polycyclic Aromatic Hydrocarbons 91-123 aryl hydrocarbon receptor Homo sapiens 231-256 27424142-3 2016 Among several carcinogenic and teratogenic components of cigarette smoke condensate (CSC), polycyclic aromatic hydrocarbons (PAHs) display a preeminent role in accelerating germ cell death via the cytoplasmic transcription factor, aryl hydrocarbon receptor (AHR) that is present across all stages of spermatogenesis. Polycyclic Aromatic Hydrocarbons 91-123 aryl hydrocarbon receptor Homo sapiens 258-261 27424142-3 2016 Among several carcinogenic and teratogenic components of cigarette smoke condensate (CSC), polycyclic aromatic hydrocarbons (PAHs) display a preeminent role in accelerating germ cell death via the cytoplasmic transcription factor, aryl hydrocarbon receptor (AHR) that is present across all stages of spermatogenesis. Polycyclic Aromatic Hydrocarbons 125-129 aryl hydrocarbon receptor Homo sapiens 231-256 27424142-3 2016 Among several carcinogenic and teratogenic components of cigarette smoke condensate (CSC), polycyclic aromatic hydrocarbons (PAHs) display a preeminent role in accelerating germ cell death via the cytoplasmic transcription factor, aryl hydrocarbon receptor (AHR) that is present across all stages of spermatogenesis. Polycyclic Aromatic Hydrocarbons 125-129 aryl hydrocarbon receptor Homo sapiens 258-261 27565807-8 2016 We observed significant interactions between maternal PAH exposure and SNPs on cord B[ a ]P-DNA adducts in the following genes: maternal CYP1A1 and GSTT2 , and newborn CYP1A1 and CYP1B1 . Polycyclic Aromatic Hydrocarbons 54-57 glutathione S-transferase theta 2 (gene/pseudogene) Homo sapiens 148-153 27565807-8 2016 We observed significant interactions between maternal PAH exposure and SNPs on cord B[ a ]P-DNA adducts in the following genes: maternal CYP1A1 and GSTT2 , and newborn CYP1A1 and CYP1B1 . Polycyclic Aromatic Hydrocarbons 54-57 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 168-174 27565807-8 2016 We observed significant interactions between maternal PAH exposure and SNPs on cord B[ a ]P-DNA adducts in the following genes: maternal CYP1A1 and GSTT2 , and newborn CYP1A1 and CYP1B1 . Polycyclic Aromatic Hydrocarbons 54-57 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 179-185 27617342-5 2016 Relative oral bioavailability (RBA) of the BaP from soil was estimated by comparing the area under the curve (AUC) for 3H concentration versus time in blood with the AUC observed from the same PAH mixture dosed in a food matrix. Polycyclic Aromatic Hydrocarbons 193-196 prohibitin 2 Rattus norvegicus 43-46 27565316-8 2016 It also needs to be emphasised that soil SL-BIT, for which better reduction of PAHs was noted, was also characterised by a lower affinity towards those compounds than soil SL-COK. Polycyclic Aromatic Hydrocarbons 79-83 signal regulatory protein alpha Homo sapiens 44-47 27613327-7 2016 Chrysene and triphenylene, dibenzo[a,h]anthracene, benzo[ghi]perylene, azaarenes and oxygenated polycyclic aromatic hydrocarbons (carbonyl-OPAHs) were all associated with EGFR-TKI-dependent reduced cell viability after 72-h exposure to the PM2.5. Polycyclic Aromatic Hydrocarbons 96-128 epidermal growth factor receptor Homo sapiens 171-175 27396317-3 2016 Naphthalene and BaP, were the dominant PAH species and potentially carcinogenic PAH species in the shallow groundwater of the study area, and they account for 89.97% of PAHs and 82.62% of PAHC7, respectively. Polycyclic Aromatic Hydrocarbons 39-42 prohibitin 2 Homo sapiens 16-19 27396317-3 2016 Naphthalene and BaP, were the dominant PAH species and potentially carcinogenic PAH species in the shallow groundwater of the study area, and they account for 89.97% of PAHs and 82.62% of PAHC7, respectively. Polycyclic Aromatic Hydrocarbons 80-83 prohibitin 2 Homo sapiens 16-19 27396317-3 2016 Naphthalene and BaP, were the dominant PAH species and potentially carcinogenic PAH species in the shallow groundwater of the study area, and they account for 89.97% of PAHs and 82.62% of PAHC7, respectively. Polycyclic Aromatic Hydrocarbons 170-174 prohibitin 2 Homo sapiens 16-19 27503386-11 2016 Interestingly, we also found that As+3 and BP-diol increased CYP1A1 and CYP1B1 expression, suggesting that increased PAH metabolism may also contribute to genotoxicity. Polycyclic Aromatic Hydrocarbons 117-120 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 72-78 27603496-1 2016 DNA polymerase (pol) kappa efficiently catalyzes error-free translesion DNA synthesis (TLS) opposite bulky N2-guanyl lesions induced by carcinogens such as polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 156-188 FUS RNA binding protein Homo sapiens 87-90 27369091-9 2016 Exposure to GDI engine exhaust upregulated genes involved in PAH metabolism, including Cyp1a1 (2.71, SE=0.22), and Cyp1b1 (3.24, SE=0.12) compared to HEPA filtered air (p<0.05). Polycyclic Aromatic Hydrocarbons 61-64 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 87-93 29964410-3 2016 The results indicated that the concentration of total PAHs ( PAHs) in the surface water ranged from 17.7-110 ng L-1 with an average value of 42.6 ng L-1. Polycyclic Aromatic Hydrocarbons 54-58 immunoglobulin kappa variable 1-16 Homo sapiens 112-115 29964410-3 2016 The results indicated that the concentration of total PAHs ( PAHs) in the surface water ranged from 17.7-110 ng L-1 with an average value of 42.6 ng L-1. Polycyclic Aromatic Hydrocarbons 54-58 immunoglobulin kappa variable 1-16 Homo sapiens 149-152 29964410-3 2016 The results indicated that the concentration of total PAHs ( PAHs) in the surface water ranged from 17.7-110 ng L-1 with an average value of 42.6 ng L-1. Polycyclic Aromatic Hydrocarbons 61-65 immunoglobulin kappa variable 1-16 Homo sapiens 112-115 29964410-3 2016 The results indicated that the concentration of total PAHs ( PAHs) in the surface water ranged from 17.7-110 ng L-1 with an average value of 42.6 ng L-1. Polycyclic Aromatic Hydrocarbons 61-65 immunoglobulin kappa variable 1-16 Homo sapiens 149-152 27713569-1 2016 The aryl hydrocarbon receptor (Ahr) is a highly conserved nuclear receptor that plays an important role in the manifestation of toxicity induced by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 148-180 aryl-hydrocarbon receptor Mus musculus 4-29 27713569-1 2016 The aryl hydrocarbon receptor (Ahr) is a highly conserved nuclear receptor that plays an important role in the manifestation of toxicity induced by polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 148-180 aryl-hydrocarbon receptor Mus musculus 31-34 27236571-0 2016 Polycyclic aromatic hydrocarbons are associated with insulin receptor substrate 2 methylation in adipose tissues of Korean women. Polycyclic Aromatic Hydrocarbons 0-32 insulin receptor substrate 2 Homo sapiens 53-81 27236571-4 2016 IRS2 methylation alone was significantly associated with concentrations of individual PAH chemicals. Polycyclic Aromatic Hydrocarbons 86-89 insulin receptor substrate 2 Homo sapiens 0-4 27236571-5 2016 When the PAH summary measure was used, the odds ratios of IRS2 hypermethylation across quartile of the PAH summary measure were 1, 1.7, 2.0, and 11.2 (95% confidence interval: 1.5-84.0) after adjusting for age and BMI (P trend=0.02). Polycyclic Aromatic Hydrocarbons 9-12 insulin receptor substrate 2 Homo sapiens 58-62 27236571-5 2016 When the PAH summary measure was used, the odds ratios of IRS2 hypermethylation across quartile of the PAH summary measure were 1, 1.7, 2.0, and 11.2 (95% confidence interval: 1.5-84.0) after adjusting for age and BMI (P trend=0.02). Polycyclic Aromatic Hydrocarbons 103-106 insulin receptor substrate 2 Homo sapiens 58-62 27236571-6 2016 The strength of association between PAH summary measure and IRS2 hypermethylation was as similar as that of BMI. Polycyclic Aromatic Hydrocarbons 36-39 insulin receptor substrate 2 Homo sapiens 60-64 27502456-6 2016 Almost all medium molecular weight (MMW) and high molecular weight (HMW) PAH TEQs increased for particle- and gas-phases at 3 kW power output compared to 2 kW without the use of NTP. Polycyclic Aromatic Hydrocarbons 73-76 promoter of MAT2A antisense radiation-induced circulating long non-coding RNA Homo sapiens 96-105 27486223-4 2016 Functional analysis of the amino acid variant Ala381 within the AHR carried by Neandertals and nonhuman primates indicate enhanced polycyclic aromatic hydrocarbon (PAH) binding, DNA binding capacity, and AHR mediated transcriptional activity compared with the human AHR. Polycyclic Aromatic Hydrocarbons 131-162 aryl hydrocarbon receptor Homo sapiens 64-67 27578405-1 2016 The application of magnetized graphene (G) layers synthesized on the carbon nanofibers (CNFs) (m-G/CNF) was investigated as novel adsorbent for the magnetic solid-phase extraction (MSPE) of polycyclic aromatic hydrocarbons (PAHs) in water samples followed by gas chromatography-flame ionization detector (GC-FID). Polycyclic Aromatic Hydrocarbons 190-222 NPHS1 adhesion molecule, nephrin Homo sapiens 88-91 27578405-1 2016 The application of magnetized graphene (G) layers synthesized on the carbon nanofibers (CNFs) (m-G/CNF) was investigated as novel adsorbent for the magnetic solid-phase extraction (MSPE) of polycyclic aromatic hydrocarbons (PAHs) in water samples followed by gas chromatography-flame ionization detector (GC-FID). Polycyclic Aromatic Hydrocarbons 224-228 NPHS1 adhesion molecule, nephrin Homo sapiens 88-91 28959603-0 2016 Differential cellular metabolite alterations in HaCaT cells caused by exposure to the aryl hydrocarbon receptor-binding polycyclic aromatic hydrocarbons chrysene, benzo[a]pyrene and dibenzo[a,l]pyrene. Polycyclic Aromatic Hydrocarbons 120-152 aryl hydrocarbon receptor Homo sapiens 86-111 27541867-0 2016 Synthesis of NBN-Type Zigzag-Edged Polycyclic Aromatic Hydrocarbons: 1,9-Diaza-9a-boraphenalene as a Structural Motif. Polycyclic Aromatic Hydrocarbons 35-67 nibrin Homo sapiens 13-16 27444380-1 2016 Cytochrome P4501A1 is involved in the metabolism of carcinogenic polycyclic aromatic hydrocarbons; therefore, its inhibition interferes with the carcinogenesis process induced by these compounds in rats. Polycyclic Aromatic Hydrocarbons 65-97 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 0-18 27341155-0 2016 Particulate PAHs and n-alkanes in the air over Southern and Eastern Mediterranean Sea. Polycyclic Aromatic Hydrocarbons 12-16 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 82-85 27571070-9 2016 Unlike B[a]P, induction of the aryl hydrocarbon receptor, measured as mRNA expression levels of CYP1A1 and CYP1B1, was low after treatment with polycyclic aromatic hydrocarbon (PAH) nitro-derivatives. Polycyclic Aromatic Hydrocarbons 144-175 aryl hydrocarbon receptor Homo sapiens 31-56 27571070-9 2016 Unlike B[a]P, induction of the aryl hydrocarbon receptor, measured as mRNA expression levels of CYP1A1 and CYP1B1, was low after treatment with polycyclic aromatic hydrocarbon (PAH) nitro-derivatives. Polycyclic Aromatic Hydrocarbons 144-175 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 96-102 27571070-9 2016 Unlike B[a]P, induction of the aryl hydrocarbon receptor, measured as mRNA expression levels of CYP1A1 and CYP1B1, was low after treatment with polycyclic aromatic hydrocarbon (PAH) nitro-derivatives. Polycyclic Aromatic Hydrocarbons 144-175 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 107-113 27571070-9 2016 Unlike B[a]P, induction of the aryl hydrocarbon receptor, measured as mRNA expression levels of CYP1A1 and CYP1B1, was low after treatment with polycyclic aromatic hydrocarbon (PAH) nitro-derivatives. Polycyclic Aromatic Hydrocarbons 177-180 aryl hydrocarbon receptor Homo sapiens 31-56 27571070-9 2016 Unlike B[a]P, induction of the aryl hydrocarbon receptor, measured as mRNA expression levels of CYP1A1 and CYP1B1, was low after treatment with polycyclic aromatic hydrocarbon (PAH) nitro-derivatives. Polycyclic Aromatic Hydrocarbons 177-180 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 96-102 27571070-9 2016 Unlike B[a]P, induction of the aryl hydrocarbon receptor, measured as mRNA expression levels of CYP1A1 and CYP1B1, was low after treatment with polycyclic aromatic hydrocarbon (PAH) nitro-derivatives. Polycyclic Aromatic Hydrocarbons 177-180 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 107-113 27706624-5 2016 A large number of genetic polymorphisms has been reported for CYP1A1, the gene that is responsible for enzymes involved in stage I detoxification of xenobiotics; this gene is located at 15q22-24, and encodes an isoenzyme that catalyzes the oxidation of polycyclic aromatic hydrocarbons present in phenolic compounds and epoxides. Polycyclic Aromatic Hydrocarbons 253-285 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 62-68 27136727-2 2016 The rapid PAH desorbing fraction (Frap), which is weakly and reversibly sorbed to soils, is called the bioaccessible fraction, and can be estimated by non-exhaustive aqueous extractions. Polycyclic Aromatic Hydrocarbons 10-13 mechanistic target of rapamycin kinase Homo sapiens 34-38 27251443-1 2016 Cytochrome P450 (CYP) enzymes play important roles in the metabolism of exogenous compounds such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 100-132 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 27251443-1 2016 Cytochrome P450 (CYP) enzymes play important roles in the metabolism of exogenous compounds such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 100-132 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-20 27251443-1 2016 Cytochrome P450 (CYP) enzymes play important roles in the metabolism of exogenous compounds such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 134-138 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 27251443-1 2016 Cytochrome P450 (CYP) enzymes play important roles in the metabolism of exogenous compounds such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 134-138 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-20 27486223-4 2016 Functional analysis of the amino acid variant Ala381 within the AHR carried by Neandertals and nonhuman primates indicate enhanced polycyclic aromatic hydrocarbon (PAH) binding, DNA binding capacity, and AHR mediated transcriptional activity compared with the human AHR. Polycyclic Aromatic Hydrocarbons 164-167 aryl hydrocarbon receptor Homo sapiens 64-67 27486223-6 2016 The resulting CYP1A1/CYP1B1 enzymes are responsible for PAH first pass metabolism, which can result in the generation of toxic intermediates and perhaps AHR-associated toxicities. Polycyclic Aromatic Hydrocarbons 56-59 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-20 27486223-6 2016 The resulting CYP1A1/CYP1B1 enzymes are responsible for PAH first pass metabolism, which can result in the generation of toxic intermediates and perhaps AHR-associated toxicities. Polycyclic Aromatic Hydrocarbons 56-59 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 21-27 27486223-6 2016 The resulting CYP1A1/CYP1B1 enzymes are responsible for PAH first pass metabolism, which can result in the generation of toxic intermediates and perhaps AHR-associated toxicities. Polycyclic Aromatic Hydrocarbons 56-59 aryl hydrocarbon receptor Homo sapiens 153-156 25533354-8 2016 Our results show that high concentrations of PAHs and elemental Ni were strongly associated with high apoptosis rates and high expression of IL-1beta, in addition, Fe element was associated with the ROS level, furthermore, Fe and Cr element were associated with DNA damage in BEAS-2B cells. Polycyclic Aromatic Hydrocarbons 45-49 interleukin 1 beta Homo sapiens 141-149 27262937-2 2016 Subsequent to the discovery of the AW population in the early 1990s, these fish were shown to be recalcitrant to CYP1A induction by PAHs under experimental conditions, and even to the time of this study, killifish embryos collected from the AW site are resistant to developmental deformities typically associated with exposure to PAHs in reference fish. Polycyclic Aromatic Hydrocarbons 132-136 cytochrome P450 1A1 Fundulus heteroclitus 113-118 27285958-2 2016 RECENT FINDINGS: Components of tobacco smoke such as polycyclic aromatic hydrocarbons lead to transcriptional upregulation of a number of genes, including members of the cytochrome P450 (CYP) family, in particular CYP1B1 and CYP1A1. Polycyclic Aromatic Hydrocarbons 53-85 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 225-231 27243113-3 2016 CYP1A1*2A (6235 T/C, rs4646903, MspI) is thought to be associated with an increased risk of CRC because of its role in metabolic activation of polycyclic aromatic hydrocarbons; however, the results of previous studies are conflicting. Polycyclic Aromatic Hydrocarbons 143-175 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 27150732-10 2016 In the few cases where findings did occur, the polycyclic aromatic hydrocarbon (PAH) content was higher than in related substances, and, in support of one possible adverse outcome pathway, one in-vitro study reported reduced thyroid peroxidase (TPO) activity with exposure to some PAH compounds (pyrene, benzo(k)fluoranthene, and benzo(e)pyrene). Polycyclic Aromatic Hydrocarbons 80-83 thyroid peroxidase Homo sapiens 225-243 28116098-0 2016 Cyp1b1-mediated suppression of lymphoid progenitors in bone marrow by polycyclic aromatic hydrocarbons coordinately impacts spleen and thymus: a selective role for the Ah Receptor. Polycyclic Aromatic Hydrocarbons 70-102 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 0-6 27150732-10 2016 In the few cases where findings did occur, the polycyclic aromatic hydrocarbon (PAH) content was higher than in related substances, and, in support of one possible adverse outcome pathway, one in-vitro study reported reduced thyroid peroxidase (TPO) activity with exposure to some PAH compounds (pyrene, benzo(k)fluoranthene, and benzo(e)pyrene). Polycyclic Aromatic Hydrocarbons 80-83 thyroid peroxidase Homo sapiens 245-248 27279258-1 2016 Fluorescence quenching (FQ) is extensively used for quantitative assessment of partition coefficients (KOC) of polycyclic aromatic hydrocarbons (PAHs) to natural organic materials - humic substances (HS). Polycyclic Aromatic Hydrocarbons 111-143 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 103-106 27279258-1 2016 Fluorescence quenching (FQ) is extensively used for quantitative assessment of partition coefficients (KOC) of polycyclic aromatic hydrocarbons (PAHs) to natural organic materials - humic substances (HS). Polycyclic Aromatic Hydrocarbons 145-149 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 103-106 27279258-2 2016 The presence of bound PAHs with incompletely quenched fluorescence would lead to underestimation of the KOC values measured by this technique. Polycyclic Aromatic Hydrocarbons 22-26 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 104-107 25913286-5 2016 PAHs enter the cell via aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 0-4 aryl hydrocarbon receptor Homo sapiens 24-49 25913286-5 2016 PAHs enter the cell via aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 0-4 aryl hydrocarbon receptor Homo sapiens 51-54 25913286-8 2016 TiO2 NPs thereby prevent the entry of PAHs into the cell via AHR and hence protect cells against the deleterious effects induced by PAHs. Polycyclic Aromatic Hydrocarbons 38-42 aryl hydrocarbon receptor Homo sapiens 61-64 27093470-10 2016 The modifying effect of rs2910164 on the PAHs-HRV associations suggested miR-146a may mediate the effects of PAH exposure on HRV. Polycyclic Aromatic Hydrocarbons 41-44 microRNA 146a Homo sapiens 73-81 26995643-0 2016 Au nanoparticles grafted on Fe3O4 as effective SERS substrates for label-free detection of the 16 EPA priority polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 111-143 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 47-51 27353300-2 2016 Benzo[alpha]pyrene (B[alpha]P) is the major compound of PAHs that acts by activating aryl hydrocarbon receptor (AhR) in cells. Polycyclic Aromatic Hydrocarbons 56-60 aryl-hydrocarbon receptor Mus musculus 85-110 27353300-2 2016 Benzo[alpha]pyrene (B[alpha]P) is the major compound of PAHs that acts by activating aryl hydrocarbon receptor (AhR) in cells. Polycyclic Aromatic Hydrocarbons 56-60 aryl-hydrocarbon receptor Mus musculus 112-115 27107589-6 2016 The results showed that concentrations of BaP, a PAH that serves as an indicator of PAH pollution, exceeded the Chinese national standard by 4-12 times. Polycyclic Aromatic Hydrocarbons 49-52 prohibitin 2 Homo sapiens 42-45 27107589-6 2016 The results showed that concentrations of BaP, a PAH that serves as an indicator of PAH pollution, exceeded the Chinese national standard by 4-12 times. Polycyclic Aromatic Hydrocarbons 84-87 prohibitin 2 Homo sapiens 42-45 27107589-8 2016 The toxic equivalents quantity (i.e., quantity of total PAHs with an equivalent toxicity to BaP) ranged from 13.35 to 22.54 ng/m(3) during the central heating period of winter and spring. Polycyclic Aromatic Hydrocarbons 56-60 prohibitin 2 Homo sapiens 92-95 30090425-6 2016 The up-regulation of MGMT and MLH1 was correlated with the elevated H3K36me3 in the PAH-exposed workers (P < 0.001). Polycyclic Aromatic Hydrocarbons 84-87 O-6-methylguanine-DNA methyltransferase Homo sapiens 21-25 30090425-6 2016 The up-regulation of MGMT and MLH1 was correlated with the elevated H3K36me3 in the PAH-exposed workers (P < 0.001). Polycyclic Aromatic Hydrocarbons 84-87 mutL homolog 1 Homo sapiens 30-34 27015123-0 2016 Loss of HIF-1alpha in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model. Polycyclic Aromatic Hydrocarbons 82-85 hypoxia inducible factor 1, alpha subunit Mus musculus 8-18 27015123-0 2016 Loss of HIF-1alpha in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model. Polycyclic Aromatic Hydrocarbons 82-85 aryl-hydrocarbon receptor Mus musculus 45-48 27129092-3 2016 Aryl hydrocarbon receptor (AhR) is important in regulating environmental exposure to xenobiotics, including benzopyrenes (BP), a major polycyclic aromatic hydrocarbon (PAH) present in cigarette smoke. Polycyclic Aromatic Hydrocarbons 135-166 aryl hydrocarbon receptor Homo sapiens 0-25 27129092-3 2016 Aryl hydrocarbon receptor (AhR) is important in regulating environmental exposure to xenobiotics, including benzopyrenes (BP), a major polycyclic aromatic hydrocarbon (PAH) present in cigarette smoke. Polycyclic Aromatic Hydrocarbons 135-166 aryl hydrocarbon receptor Homo sapiens 27-30 27129092-3 2016 Aryl hydrocarbon receptor (AhR) is important in regulating environmental exposure to xenobiotics, including benzopyrenes (BP), a major polycyclic aromatic hydrocarbon (PAH) present in cigarette smoke. Polycyclic Aromatic Hydrocarbons 168-171 aryl hydrocarbon receptor Homo sapiens 0-25 27129092-3 2016 Aryl hydrocarbon receptor (AhR) is important in regulating environmental exposure to xenobiotics, including benzopyrenes (BP), a major polycyclic aromatic hydrocarbon (PAH) present in cigarette smoke. Polycyclic Aromatic Hydrocarbons 168-171 aryl hydrocarbon receptor Homo sapiens 27-30 27043777-2 2016 Great AhR-mediated potencies were found in fractions containing aromatic compounds with log Kow values of 5-8, and relatively great concentrations of styrene oligomers (SOs) and polycyclic aromatic hydrocarbons (PAHs) were detected in those fractions. Polycyclic Aromatic Hydrocarbons 212-216 aryl hydrocarbon receptor Homo sapiens 6-9 27043777-9 2016 RePs of 3 SOs could be derived, which were 1000- to 10,000-fold less than that of one representative potent AhR active PAH, benzo[a]pyrene. Polycyclic Aromatic Hydrocarbons 119-122 aryl hydrocarbon receptor Homo sapiens 108-111 27015123-8 2016 In chemical-induced carcinogenesis, HIF-1alpha in macrophages maintains ARNT expression to facilitate PAH-biotransformation. Polycyclic Aromatic Hydrocarbons 102-105 hypoxia inducible factor 1, alpha subunit Mus musculus 36-46 27015123-8 2016 In chemical-induced carcinogenesis, HIF-1alpha in macrophages maintains ARNT expression to facilitate PAH-biotransformation. Polycyclic Aromatic Hydrocarbons 102-105 aryl hydrocarbon receptor nuclear translocator Mus musculus 72-76 26915591-7 2016 The data implied that the reactivity of PAH (electron affinity and ionization potential) affected its treatability more than did its hydrophobicity (Kow, Koc and Sw), particularly using experimental conditions under which PAHs could be effectively oxidized. Polycyclic Aromatic Hydrocarbons 222-226 insulin like growth factor 2 mRNA binding protein 3 Homo sapiens 154-157 26845364-6 2016 However, PAH fingerprints associated with STP sediments correlated poorly with those of urban soils and marine sediments, but were similar to coal tar, historically consistent with by-products produced by the former coking operations. Polycyclic Aromatic Hydrocarbons 9-12 thyroid hormone receptor interactor 10 Homo sapiens 42-45 26995643-7 2016 As a result of its remarkable sensitivity, the Fe3O4@Au-based SERS assay has been applied to detect the 16 EPA priority PAHs. Polycyclic Aromatic Hydrocarbons 120-124 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 62-66 26844782-0 2016 Effect through inhalation on human health of PM1 bound polycyclic aromatic hydrocarbons collected from foggy days in northern part of India. Polycyclic Aromatic Hydrocarbons 55-87 transmembrane protein 11 Homo sapiens 45-48 26637425-1 2016 A novel biphasic system containing mineral medium and sand coated with a biologically weathered creosote-PAH mixture was developed to specifically enrich the high molecular weight polycyclic aromatic hydrocarbon (HMW PAH)-degrading community from a creosote-polluted soil. Polycyclic Aromatic Hydrocarbons 105-108 cilia and flagella associated protein 97 Homo sapiens 213-216 26637425-1 2016 A novel biphasic system containing mineral medium and sand coated with a biologically weathered creosote-PAH mixture was developed to specifically enrich the high molecular weight polycyclic aromatic hydrocarbon (HMW PAH)-degrading community from a creosote-polluted soil. Polycyclic Aromatic Hydrocarbons 180-211 cilia and flagella associated protein 97 Homo sapiens 213-216 26637425-1 2016 A novel biphasic system containing mineral medium and sand coated with a biologically weathered creosote-PAH mixture was developed to specifically enrich the high molecular weight polycyclic aromatic hydrocarbon (HMW PAH)-degrading community from a creosote-polluted soil. Polycyclic Aromatic Hydrocarbons 217-220 cilia and flagella associated protein 97 Homo sapiens 213-216 28231110-7 2016 Conversely, there appeared to be a negative correlation between AhR activity and the number of chlorine residues present on halogenated PAH derivatives. Polycyclic Aromatic Hydrocarbons 136-139 aryl hydrocarbon receptor Homo sapiens 64-67 26372663-0 2016 TNFalpha and IL-6 Responses to Particulate Matter in Vitro: Variation According to PM Size, Season, and Polycyclic Aromatic Hydrocarbon and Soil Content. Polycyclic Aromatic Hydrocarbons 104-135 tumor necrosis factor Homo sapiens 0-8 26372663-15 2016 CONCLUSIONS: Variations in PM soil and PAH content underlie seasonal and PM size-related patterns in TNFalpha secretion. Polycyclic Aromatic Hydrocarbons 39-42 tumor necrosis factor Homo sapiens 101-109 26681325-6 2016 The outcomes suggest that legislation on ship traffic, which focused on the issue of the emissions of sulphur oxides, could be an efficient method also to reduce the impact of shipping on primary particulate matter concentration; on the other hand, we did not observe a significant reduction in the contribution of ship traffic and harbour activities to particulate PAHs and metals. Polycyclic Aromatic Hydrocarbons 366-370 inositol polyphosphate-5-phosphatase D Homo sapiens 41-45 26681325-6 2016 The outcomes suggest that legislation on ship traffic, which focused on the issue of the emissions of sulphur oxides, could be an efficient method also to reduce the impact of shipping on primary particulate matter concentration; on the other hand, we did not observe a significant reduction in the contribution of ship traffic and harbour activities to particulate PAHs and metals. Polycyclic Aromatic Hydrocarbons 366-370 inositol polyphosphate-5-phosphatase D Homo sapiens 176-180 27642318-0 2016 Simultaneous Determination of 13 Priority Polycyclic Aromatic Hydrocarbons in Tehran"s Tap Water and Water for Injection Samples Using Dispersive Liquid-Liquid Micro Extraction Method and Gas Chromatography-Mass Spectrometry. Polycyclic Aromatic Hydrocarbons 42-74 nuclear RNA export factor 1 Homo sapiens 87-90 27642318-4 2016 In this study, 13 priority polycyclic aromatic hydrocarbons (PAHs) were determined in tap water samples of Tehran and water for injection. Polycyclic Aromatic Hydrocarbons 27-59 nuclear RNA export factor 1 Homo sapiens 86-89 27642318-4 2016 In this study, 13 priority polycyclic aromatic hydrocarbons (PAHs) were determined in tap water samples of Tehran and water for injection. Polycyclic Aromatic Hydrocarbons 61-65 nuclear RNA export factor 1 Homo sapiens 86-89 27642318-8 2016 The concentration of PAHs in all tap water as well as water for injection samples were lower than the limit of quantification of PAHs. Polycyclic Aromatic Hydrocarbons 21-25 nuclear RNA export factor 1 Homo sapiens 33-36 26922534-6 2016 COX-2 expression was decreased while PPARdelta expression and cPLA2 activity was increased after fatty acid supplementation and PAHs treatment. Polycyclic Aromatic Hydrocarbons 128-132 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-5 26922534-6 2016 COX-2 expression was decreased while PPARdelta expression and cPLA2 activity was increased after fatty acid supplementation and PAHs treatment. Polycyclic Aromatic Hydrocarbons 128-132 peroxisome proliferator activated receptor delta Homo sapiens 37-46 26922534-6 2016 COX-2 expression was decreased while PPARdelta expression and cPLA2 activity was increased after fatty acid supplementation and PAHs treatment. Polycyclic Aromatic Hydrocarbons 128-132 phospholipase A2 group IVA Homo sapiens 62-67 26922534-9 2016 The altered profile of lipid mediators from n-3 FA as well as repression of the COX-2 protein by n-3 PUFAs in A549 cells incubated with PAHs suggests anti-inflammatory and pro-resolving properties of DHA and EPA. Polycyclic Aromatic Hydrocarbons 136-140 mitochondrially encoded cytochrome c oxidase II Homo sapiens 80-85 26802354-9 2016 The exposure to vanadium and PAHs may cause a reduction in the levels of amino acids and carbohydrates by elevating PPAR and insulin signaling, as well as oxidative/nitrosative stress. Polycyclic Aromatic Hydrocarbons 29-33 peroxisome proliferator activated receptor alpha Homo sapiens 116-120 26802354-9 2016 The exposure to vanadium and PAHs may cause a reduction in the levels of amino acids and carbohydrates by elevating PPAR and insulin signaling, as well as oxidative/nitrosative stress. Polycyclic Aromatic Hydrocarbons 29-33 insulin Homo sapiens 125-132 27141907-6 2016 Cytochrome P450 (CYP450s) and glutathione S-transferases (GSTs) are the main metabolic enzymes of PAH and many other xenobiotics, and the polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1 and GSTT2 may be associated with the risk of preterm birth. Polycyclic Aromatic Hydrocarbons 98-101 glutathione S-transferase mu 1 Homo sapiens 58-62 27141907-6 2016 Cytochrome P450 (CYP450s) and glutathione S-transferases (GSTs) are the main metabolic enzymes of PAH and many other xenobiotics, and the polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1 and GSTT2 may be associated with the risk of preterm birth. Polycyclic Aromatic Hydrocarbons 98-101 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 163-169 27141907-6 2016 Cytochrome P450 (CYP450s) and glutathione S-transferases (GSTs) are the main metabolic enzymes of PAH and many other xenobiotics, and the polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1 and GSTT2 may be associated with the risk of preterm birth. Polycyclic Aromatic Hydrocarbons 98-101 glutathione S-transferase mu 1 Homo sapiens 171-176 27141907-6 2016 Cytochrome P450 (CYP450s) and glutathione S-transferases (GSTs) are the main metabolic enzymes of PAH and many other xenobiotics, and the polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1 and GSTT2 may be associated with the risk of preterm birth. Polycyclic Aromatic Hydrocarbons 98-101 glutathione S-transferase theta 1 Homo sapiens 178-183 27141907-6 2016 Cytochrome P450 (CYP450s) and glutathione S-transferases (GSTs) are the main metabolic enzymes of PAH and many other xenobiotics, and the polymorphisms of CYP1A1, CYP2E1, GSTM1, GSTT1 and GSTT2 may be associated with the risk of preterm birth. Polycyclic Aromatic Hydrocarbons 98-101 glutathione S-transferase theta 2 (gene/pseudogene) Homo sapiens 188-193 26806662-0 2016 Distribution and sources of polycyclic aromatic hydrocarbons in surface sediments from the Bering Sea and western Arctic Ocean. Polycyclic Aromatic Hydrocarbons 28-60 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 98-101 26122564-3 2016 Accumulation of PAH degraders was particularly high in the SML, where PAHs accumulated. Polycyclic Aromatic Hydrocarbons 70-74 phenylalanine hydroxylase Homo sapiens 16-19 25564368-9 2016 We found positive associations of traffic-related pollutants (EC, BC, primary organic carbon, PM 0.25-2.5 PAH and/or PM 0.25 PAH, and NOx) with NFE2L2, Nrf2-mediated genes (HMOX1, NQO1, and SOD2), CYP1B1, IL1B, and SELP. Polycyclic Aromatic Hydrocarbons 106-109 NFE2 like bZIP transcription factor 2 Homo sapiens 144-150 25564368-9 2016 We found positive associations of traffic-related pollutants (EC, BC, primary organic carbon, PM 0.25-2.5 PAH and/or PM 0.25 PAH, and NOx) with NFE2L2, Nrf2-mediated genes (HMOX1, NQO1, and SOD2), CYP1B1, IL1B, and SELP. Polycyclic Aromatic Hydrocarbons 125-128 NFE2 like bZIP transcription factor 2 Homo sapiens 144-150 26656082-5 2016 In addition, clear mRNA expression of CYP1A1, which is associated with aryl hydrocarbon receptor (AhR)-mediated activation, was observed following the exposure of cells to two PAHs (B[k]FA and B[b]FA) and three oxy-PAHs (1,2-naphthoquinone, 11H-benzo[b]fluoren-11-one and BPO). Polycyclic Aromatic Hydrocarbons 176-180 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 38-44 26656082-5 2016 In addition, clear mRNA expression of CYP1A1, which is associated with aryl hydrocarbon receptor (AhR)-mediated activation, was observed following the exposure of cells to two PAHs (B[k]FA and B[b]FA) and three oxy-PAHs (1,2-naphthoquinone, 11H-benzo[b]fluoren-11-one and BPO). Polycyclic Aromatic Hydrocarbons 176-180 aryl-hydrocarbon receptor Mus musculus 71-96 26656082-5 2016 In addition, clear mRNA expression of CYP1A1, which is associated with aryl hydrocarbon receptor (AhR)-mediated activation, was observed following the exposure of cells to two PAHs (B[k]FA and B[b]FA) and three oxy-PAHs (1,2-naphthoquinone, 11H-benzo[b]fluoren-11-one and BPO). Polycyclic Aromatic Hydrocarbons 176-180 aryl-hydrocarbon receptor Mus musculus 98-101 27088078-8 2016 Epigenetic differences within the Bdnf IV promoter correlated with Bdnf gene expression, but not with the observed behavioral outcomes, suggesting that additional targets may account for these PAH-associated effects. Polycyclic Aromatic Hydrocarbons 193-196 brain derived neurotrophic factor Mus musculus 34-38 28231110-6 2016 Furthermore, there was a positive link between AhR activity and the number of aromatic rings in the PAH derivatives. Polycyclic Aromatic Hydrocarbons 100-103 aryl hydrocarbon receptor Homo sapiens 47-50 26706770-6 2016 The concentrations of PAHs and BEQs of the AhR-mediated activity attributed to these chemicals in the exhaustive extracts can be back calculated from those in the PDMS extracts via a general organic carbon-PDMS partition coefficient. Polycyclic Aromatic Hydrocarbons 22-26 aryl hydrocarbon receptor Homo sapiens 43-46 26924856-4 2016 Spitzer-IRS mid-infrared spectroscopic imaging of the nearby, oxygen-rich planetary nebula NGC 6720 reveals the presence of the 11.3 mum aromatic (PAH) emission band. Polycyclic Aromatic Hydrocarbons 147-150 isoleucyl-tRNA synthetase 1 Homo sapiens 8-11 25398514-0 2016 Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism. Polycyclic Aromatic Hydrocarbons 13-45 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 25398514-0 2016 Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism. Polycyclic Aromatic Hydrocarbons 13-45 tumor protein p53 Homo sapiens 81-84 25398514-2 2016 We have investigated the role of TP53 in cytochrome P450 (CYP)-mediated metabolic activation of three polycyclic aromatic hydrocarbons (PAHs) in a panel of isogenic colorectal HCT116 cells with differing TP53 status. Polycyclic Aromatic Hydrocarbons 102-134 tumor protein p53 Homo sapiens 33-37 25398514-2 2016 We have investigated the role of TP53 in cytochrome P450 (CYP)-mediated metabolic activation of three polycyclic aromatic hydrocarbons (PAHs) in a panel of isogenic colorectal HCT116 cells with differing TP53 status. Polycyclic Aromatic Hydrocarbons 102-134 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 41-56 25398514-2 2016 We have investigated the role of TP53 in cytochrome P450 (CYP)-mediated metabolic activation of three polycyclic aromatic hydrocarbons (PAHs) in a panel of isogenic colorectal HCT116 cells with differing TP53 status. Polycyclic Aromatic Hydrocarbons 102-134 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 58-61 25398514-2 2016 We have investigated the role of TP53 in cytochrome P450 (CYP)-mediated metabolic activation of three polycyclic aromatic hydrocarbons (PAHs) in a panel of isogenic colorectal HCT116 cells with differing TP53 status. Polycyclic Aromatic Hydrocarbons 136-140 tumor protein p53 Homo sapiens 33-37 25398514-2 2016 We have investigated the role of TP53 in cytochrome P450 (CYP)-mediated metabolic activation of three polycyclic aromatic hydrocarbons (PAHs) in a panel of isogenic colorectal HCT116 cells with differing TP53 status. Polycyclic Aromatic Hydrocarbons 136-140 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 41-56 25398514-2 2016 We have investigated the role of TP53 in cytochrome P450 (CYP)-mediated metabolic activation of three polycyclic aromatic hydrocarbons (PAHs) in a panel of isogenic colorectal HCT116 cells with differing TP53 status. Polycyclic Aromatic Hydrocarbons 136-140 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 58-61 25398514-6 2016 Bypass of the need for metabolic activation by treating cells with the corresponding reactive PAH-diol-epoxide metabolites resulted in similar adduct levels in all cell lines, which confirms that the influence of p53 is on the metabolism of the parent PAHs. Polycyclic Aromatic Hydrocarbons 94-97 tumor protein p53 Homo sapiens 213-216 26408977-0 2016 Bioaccessibility of AhR-active PAHs in sediments contaminated by the Hebei Spirit oil spill: Application of Tenax extraction in effect-directed analysis. Polycyclic Aromatic Hydrocarbons 31-35 aryl hydrocarbon receptor Homo sapiens 20-23 26408977-3 2016 In the present study, bioaccessibility of aryl hydrocarbon receptor (AhR)-active polycyclic aromatic hydrocarbons (PAHs) in coastal sediments near the site of the Hebei Spirit oil spill (Korea, 2007) was assessed by Tenax extraction in effect-directed analysis (EDA). Polycyclic Aromatic Hydrocarbons 81-113 aryl hydrocarbon receptor Homo sapiens 42-67 26408977-3 2016 In the present study, bioaccessibility of aryl hydrocarbon receptor (AhR)-active polycyclic aromatic hydrocarbons (PAHs) in coastal sediments near the site of the Hebei Spirit oil spill (Korea, 2007) was assessed by Tenax extraction in effect-directed analysis (EDA). Polycyclic Aromatic Hydrocarbons 81-113 aryl hydrocarbon receptor Homo sapiens 69-72 26408977-3 2016 In the present study, bioaccessibility of aryl hydrocarbon receptor (AhR)-active polycyclic aromatic hydrocarbons (PAHs) in coastal sediments near the site of the Hebei Spirit oil spill (Korea, 2007) was assessed by Tenax extraction in effect-directed analysis (EDA). Polycyclic Aromatic Hydrocarbons 115-119 aryl hydrocarbon receptor Homo sapiens 42-67 26408977-3 2016 In the present study, bioaccessibility of aryl hydrocarbon receptor (AhR)-active polycyclic aromatic hydrocarbons (PAHs) in coastal sediments near the site of the Hebei Spirit oil spill (Korea, 2007) was assessed by Tenax extraction in effect-directed analysis (EDA). Polycyclic Aromatic Hydrocarbons 115-119 aryl hydrocarbon receptor Homo sapiens 69-72 26408977-7 2016 In Soxhlet and Tenax extracts, the major AhR-active PAHs were identified as C1-chrysene, C3-chrysene, and C4-phenanthrene. Polycyclic Aromatic Hydrocarbons 52-56 aryl hydrocarbon receptor Homo sapiens 41-44 26655675-11 2016 We found significant gene-environment interaction between PAH and four SNPs (EPHX1, (rs2854461), STAT4 (rs16833215), XPC (rs2228001 and rs2733532)), which became non-significant after adjusting for multiple comparisons. Polycyclic Aromatic Hydrocarbons 58-61 epoxide hydrolase 1 Homo sapiens 77-82 26655675-11 2016 We found significant gene-environment interaction between PAH and four SNPs (EPHX1, (rs2854461), STAT4 (rs16833215), XPC (rs2228001 and rs2733532)), which became non-significant after adjusting for multiple comparisons. Polycyclic Aromatic Hydrocarbons 58-61 XPC complex subunit, DNA damage recognition and repair factor Homo sapiens 117-120 26407953-8 2015 RESULTS: Women with detectable PAH-DNA adducts and methylated RARbeta (ROR 2.69, 95% CI 1.02-7.12; p for interaction = 0.03) or APC (ROR 1.76, 95% CI 0.87-3.58; p for interaction = 0.09) genes were more likely to have hormone receptor-positive tumors than other subtypes. Polycyclic Aromatic Hydrocarbons 31-34 retinoic acid receptor beta Homo sapiens 62-69 26490935-0 2016 Polycyclic aromatic hydrocarbons (PAHs) at traffic and urban background sites of northern Greece: source apportionment of ambient PAH levels and PAH-induced lung cancer risk. Polycyclic Aromatic Hydrocarbons 0-32 phenylalanine hydroxylase Homo sapiens 34-37 26490935-0 2016 Polycyclic aromatic hydrocarbons (PAHs) at traffic and urban background sites of northern Greece: source apportionment of ambient PAH levels and PAH-induced lung cancer risk. Polycyclic Aromatic Hydrocarbons 0-32 phenylalanine hydroxylase Homo sapiens 130-133 26490935-0 2016 Polycyclic aromatic hydrocarbons (PAHs) at traffic and urban background sites of northern Greece: source apportionment of ambient PAH levels and PAH-induced lung cancer risk. Polycyclic Aromatic Hydrocarbons 34-38 phenylalanine hydroxylase Homo sapiens 130-133 26701853-5 2016 Low RASSF10 expression was associated with promoter hypermethylation, which was in turn associated with polycyclic aromatic hydrocarbon and aflatoxin B1 exposure, but not DNA methyltransferase expression. Polycyclic Aromatic Hydrocarbons 104-135 Ras association domain family member 10 Homo sapiens 4-11 28959535-3 2016 However, only HOTAIR and MALAT1 were significantly associated with the level of internal PAHs exposure (urinary 1-hydroxypyrene) with adjusted beta = 0.298, P = 0.024 for HOTAIR and beta = 0.090, P = 0.034 for MALAT1. Polycyclic Aromatic Hydrocarbons 89-93 HOX transcript antisense RNA Homo sapiens 14-20 28959535-3 2016 However, only HOTAIR and MALAT1 were significantly associated with the level of internal PAHs exposure (urinary 1-hydroxypyrene) with adjusted beta = 0.298, P = 0.024 for HOTAIR and beta = 0.090, P = 0.034 for MALAT1. Polycyclic Aromatic Hydrocarbons 89-93 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 25-31 28959535-3 2016 However, only HOTAIR and MALAT1 were significantly associated with the level of internal PAHs exposure (urinary 1-hydroxypyrene) with adjusted beta = 0.298, P = 0.024 for HOTAIR and beta = 0.090, P = 0.034 for MALAT1. Polycyclic Aromatic Hydrocarbons 89-93 HOX transcript antisense RNA Homo sapiens 171-177 28959535-3 2016 However, only HOTAIR and MALAT1 were significantly associated with the level of internal PAHs exposure (urinary 1-hydroxypyrene) with adjusted beta = 0.298, P = 0.024 for HOTAIR and beta = 0.090, P = 0.034 for MALAT1. Polycyclic Aromatic Hydrocarbons 89-93 metastasis associated lung adenocarcinoma transcript 1 Homo sapiens 210-216 27250797-0 2016 Polycyclic Aromatic Hydrocarbons in Surface Water of the Southeastern Japan Sea. Polycyclic Aromatic Hydrocarbons 0-32 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 76-79 27250797-9 2016 The mean total PAH concentration in the southeastern Japan Sea was higher than the concentration in the northwestern Japan Sea (8.5 ng/L). Polycyclic Aromatic Hydrocarbons 15-18 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 59-62 27250797-10 2016 The Tsushima Current, which originates from the East China Sea with higher PAH concentration, is considered to be responsible for this higher concentration. Polycyclic Aromatic Hydrocarbons 75-78 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 59-62 26563883-3 2016 CYP2W1 has been shown to metabolize various endogenous substrates including lysophospholipids and several procarcinogens, such as polycyclic aromatic hydrocarbon. Polycyclic Aromatic Hydrocarbons 130-161 cytochrome P450 family 2 subfamily W member 1 Homo sapiens 0-6 26610293-4 2016 RESULTS: We observed statistically significant associations between PAH metabolites and levels of serum GGT, CRP, uric acid and eGFR. Polycyclic Aromatic Hydrocarbons 68-71 gamma-glutamyltransferase 1 Homo sapiens 104-107 26610293-4 2016 RESULTS: We observed statistically significant associations between PAH metabolites and levels of serum GGT, CRP, uric acid and eGFR. Polycyclic Aromatic Hydrocarbons 68-71 C-reactive protein Homo sapiens 109-112 26610293-9 2016 CONCLUSIONS: Urinary PAH metabolites were associated with serum uric acid, GGT and CRP, suggesting possible impacts on cardiometabolic and kidney function in adolescents. Polycyclic Aromatic Hydrocarbons 21-24 gamma-glutamyltransferase 1 Homo sapiens 75-78 26610293-9 2016 CONCLUSIONS: Urinary PAH metabolites were associated with serum uric acid, GGT and CRP, suggesting possible impacts on cardiometabolic and kidney function in adolescents. Polycyclic Aromatic Hydrocarbons 21-24 C-reactive protein Homo sapiens 83-86 26731659-2 2016 Benzo[a]pyrene (BaP), the most carcinogenic polycyclic aromatic hydrocarbon (PAH), is classified as a group 1 carcinogen by International Agency for Research on Cancer. Polycyclic Aromatic Hydrocarbons 44-75 prohibitin 2 Homo sapiens 16-19 26530806-1 2016 The signaling pathway of the evolutionary old transcription factor AhR is inducible by a number of small molecular weight chemicals, including toxicants such as polycyclic aromatic hydrocarbons, bacterial toxic pigments, and physiological compounds such as tryptophan derivatives or dietary indoles. Polycyclic Aromatic Hydrocarbons 161-193 aryl hydrocarbon receptor Homo sapiens 67-70 27829840-4 2016 It is generally accepted that the toxic responses of polycyclic aromatic hydrocarbons, dioxins, and structurally related compounds are mediated by activation of the AhR. Polycyclic Aromatic Hydrocarbons 53-85 aryl hydrocarbon receptor Homo sapiens 165-168 26695288-7 2016 Finally, the application of C18-DTT column was demonstrated in the separation of non-steroidal anti-inflammatory drugs, aromatic carboxylic acids, alkaloids, nucleo-analytes and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 178-210 Bardet-Biedl syndrome 9 Homo sapiens 28-31 26621329-6 2016 Inhibition of the aryl hydrocarbon receptor (AhR) pathway through the use of a chemical AhR antagonist or the siRNA-mediated silencing of AhR expression was next found to prevent DEPe-mediated induction of LAT1/CD98hc, indicating that this regulation depends on AhR, known to be activated by major chemical DEP components like polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 327-359 aryl hydrocarbon receptor Homo sapiens 18-43 26621329-6 2016 Inhibition of the aryl hydrocarbon receptor (AhR) pathway through the use of a chemical AhR antagonist or the siRNA-mediated silencing of AhR expression was next found to prevent DEPe-mediated induction of LAT1/CD98hc, indicating that this regulation depends on AhR, known to be activated by major chemical DEP components like polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 327-359 aryl hydrocarbon receptor Homo sapiens 45-48 26621329-6 2016 Inhibition of the aryl hydrocarbon receptor (AhR) pathway through the use of a chemical AhR antagonist or the siRNA-mediated silencing of AhR expression was next found to prevent DEPe-mediated induction of LAT1/CD98hc, indicating that this regulation depends on AhR, known to be activated by major chemical DEP components like polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 327-359 solute carrier family 7 member 5 Homo sapiens 206-210 26593280-0 2015 Equilibrium passive sampling as a tool to study polycyclic aromatic hydrocarbons in Baltic Sea sediment pore-water systems. Polycyclic Aromatic Hydrocarbons 48-80 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 91-94 26593280-1 2015 Solid Phase Microextraction (SPME) was applied to provide the first large scale dataset of freely dissolved concentrations for 9 polycyclic aromatic hydrocarbons (PAHs) in Baltic Sea sediment cores. Polycyclic Aromatic Hydrocarbons 129-161 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 179-182 26593280-1 2015 Solid Phase Microextraction (SPME) was applied to provide the first large scale dataset of freely dissolved concentrations for 9 polycyclic aromatic hydrocarbons (PAHs) in Baltic Sea sediment cores. Polycyclic Aromatic Hydrocarbons 163-167 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 179-182 27088078-0 2016 Impact of prenatal polycyclic aromatic hydrocarbon exposure on behavior, cortical gene expression and DNA methylation of the Bdnf gene. Polycyclic Aromatic Hydrocarbons 19-50 brain derived neurotrophic factor Mus musculus 125-129 27088078-3 2016 We hypothesized that prenatal exposure to ambient PAH in mice would be associated with impaired neurocognition, increased anxiety, altered cortical expression of Bdnf and Grin2b, and greater DNA methylation of Bdnf. Polycyclic Aromatic Hydrocarbons 50-53 brain derived neurotrophic factor Mus musculus 162-166 27088078-3 2016 We hypothesized that prenatal exposure to ambient PAH in mice would be associated with impaired neurocognition, increased anxiety, altered cortical expression of Bdnf and Grin2b, and greater DNA methylation of Bdnf. Polycyclic Aromatic Hydrocarbons 50-53 glutamate receptor, ionotropic, NMDA2B (epsilon 2) Mus musculus 171-177 27088078-3 2016 We hypothesized that prenatal exposure to ambient PAH in mice would be associated with impaired neurocognition, increased anxiety, altered cortical expression of Bdnf and Grin2b, and greater DNA methylation of Bdnf. Polycyclic Aromatic Hydrocarbons 50-53 brain derived neurotrophic factor Mus musculus 210-214 27088078-7 2016 Further, prenatal PAH exposure was associated with lower cortical expression of Grin2b and Bdnf in males, and greater Bdnf IV promoter methylation. Polycyclic Aromatic Hydrocarbons 18-21 glutamate receptor, ionotropic, NMDA2B (epsilon 2) Mus musculus 80-86 27088078-7 2016 Further, prenatal PAH exposure was associated with lower cortical expression of Grin2b and Bdnf in males, and greater Bdnf IV promoter methylation. Polycyclic Aromatic Hydrocarbons 18-21 brain derived neurotrophic factor Mus musculus 91-95 27088078-7 2016 Further, prenatal PAH exposure was associated with lower cortical expression of Grin2b and Bdnf in males, and greater Bdnf IV promoter methylation. Polycyclic Aromatic Hydrocarbons 18-21 brain derived neurotrophic factor Mus musculus 118-122 26731659-2 2016 Benzo[a]pyrene (BaP), the most carcinogenic polycyclic aromatic hydrocarbon (PAH), is classified as a group 1 carcinogen by International Agency for Research on Cancer. Polycyclic Aromatic Hydrocarbons 77-80 prohibitin 2 Homo sapiens 16-19 26247835-2 2016 The polycyclic hydrocarbons (PAHs), pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene, were found to induce Type I binding spectra with human cytochrome P450 (P450) 2A13 and were converted to various mono- and di-oxygenated products by this enzyme. Polycyclic Aromatic Hydrocarbons 29-33 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 150-177 26563544-0 2015 Distribution and source apportionment of polycyclic aromatic hydrocarbons in surface sediments from Zhoushan Archipelago and Xiangshan Harbor, East China Sea. Polycyclic Aromatic Hydrocarbons 41-73 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 154-157 26407953-8 2015 RESULTS: Women with detectable PAH-DNA adducts and methylated RARbeta (ROR 2.69, 95% CI 1.02-7.12; p for interaction = 0.03) or APC (ROR 1.76, 95% CI 0.87-3.58; p for interaction = 0.09) genes were more likely to have hormone receptor-positive tumors than other subtypes. Polycyclic Aromatic Hydrocarbons 31-34 receptor tyrosine kinase like orphan receptor 2 Homo sapiens 71-76 26407953-8 2015 RESULTS: Women with detectable PAH-DNA adducts and methylated RARbeta (ROR 2.69, 95% CI 1.02-7.12; p for interaction = 0.03) or APC (ROR 1.76, 95% CI 0.87-3.58; p for interaction = 0.09) genes were more likely to have hormone receptor-positive tumors than other subtypes. Polycyclic Aromatic Hydrocarbons 31-34 receptor tyrosine kinase like orphan receptor 1 Homo sapiens 133-138 26407953-11 2015 CONCLUSIONS: Gene-specific methylation of RARbeta, and perhaps APC, may interact with PAH-DNA adducts to increase risk of hormone receptor-positive breast cancer. Polycyclic Aromatic Hydrocarbons 86-89 retinoic acid receptor beta Homo sapiens 42-49 26756025-4 2015 Much of this risk is due to the fact that a single WTS session exposes users to large volumes of smoke that contain toxic chemicals such as carbon monoxide, cancer-causing polycyclic aromatic hydrocarbons, and volatile aldehydes. Polycyclic Aromatic Hydrocarbons 172-204 histone deacetylase 8 Homo sapiens 51-54 25976698-6 2015 The expression of AhR2 and Cyp1A, which are usually considered to mediate polycyclic aromatic hydrocarbon toxicity, were also significantly changed. Polycyclic Aromatic Hydrocarbons 74-105 aryl hydrocarbon receptor 2 Danio rerio 18-22 25976698-6 2015 The expression of AhR2 and Cyp1A, which are usually considered to mediate polycyclic aromatic hydrocarbon toxicity, were also significantly changed. Polycyclic Aromatic Hydrocarbons 74-105 cytochrome P450, family 1, subfamily A Danio rerio 27-32 26558458-1 2015 Aryl hydrocarbon receptor (AhR) is a transcription factor activated by xenobiotics, including dioxins and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 106-138 aryl hydrocarbon receptor Homo sapiens 0-25 26558458-1 2015 Aryl hydrocarbon receptor (AhR) is a transcription factor activated by xenobiotics, including dioxins and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 106-138 aryl hydrocarbon receptor Homo sapiens 27-30 26558458-1 2015 Aryl hydrocarbon receptor (AhR) is a transcription factor activated by xenobiotics, including dioxins and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 140-144 aryl hydrocarbon receptor Homo sapiens 0-25 26558458-1 2015 Aryl hydrocarbon receptor (AhR) is a transcription factor activated by xenobiotics, including dioxins and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 140-144 aryl hydrocarbon receptor Homo sapiens 27-30 26558468-2 2015 Polycyclic aromatic hydrocarbons, but not mono- or bi-aromatic hydrocarbons, are well recognized as ligands for the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl-hydrocarbon receptor Mus musculus 116-141 26558468-2 2015 Polycyclic aromatic hydrocarbons, but not mono- or bi-aromatic hydrocarbons, are well recognized as ligands for the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl-hydrocarbon receptor Mus musculus 143-146 26664351-5 2015 Epidemiologically, exposure to xenobiotic AHR ligands such as polycyclic aromatic hydrocarbons is linked to T2D. Polycyclic Aromatic Hydrocarbons 62-94 aryl-hydrocarbon receptor Mus musculus 42-45 30090347-2 2016 BaP is a polycyclic aromatic hydrocarbon generated by incomplete combustion of organic substances, thus contaminating numerous foodstuffs, and PhIP is a heterocyclic amine formed when meat is cooked. Polycyclic Aromatic Hydrocarbons 9-40 prohibitin 2 Homo sapiens 0-3 26565418-0 2015 The chemokine CXCL13 in lung cancers associated with environmental polycyclic aromatic hydrocarbons pollution. Polycyclic Aromatic Hydrocarbons 67-99 chemokine (C-X-C motif) ligand 13 Mus musculus 14-20 26565418-6 2015 Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated BaP-induced lung cancer in mice, demonstrating CXCL13"s critical role in PAH-induced lung carcinogenesis. Polycyclic Aromatic Hydrocarbons 143-146 chemokine (C-X-C motif) ligand 13 Mus musculus 14-20 26565418-6 2015 Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated BaP-induced lung cancer in mice, demonstrating CXCL13"s critical role in PAH-induced lung carcinogenesis. Polycyclic Aromatic Hydrocarbons 143-146 chemokine (C-X-C motif) receptor 5 Mus musculus 38-43 26565418-6 2015 Deficiency in Cxcl13 or its receptor, Cxcr5, significantly attenuated BaP-induced lung cancer in mice, demonstrating CXCL13"s critical role in PAH-induced lung carcinogenesis. Polycyclic Aromatic Hydrocarbons 143-146 chemokine (C-X-C motif) ligand 13 Mus musculus 117-123 25483919-0 2015 CTAB micelles assisted rGO-AgNP hybrids for SERS detection of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 62-94 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 44-48 25567057-4 2015 For the sediment extracts, a reduction of acetylcholinesterase activity to about 60% could only be shown for the Vering Canal sediment extracts; this could be correlated to high contents of acetylcholinesterase-inhibiting polycyclic aromatic hydrocarbons (PAHs) as identified by chemical analyses. Polycyclic Aromatic Hydrocarbons 222-254 acetylcholinesterase Danio rerio 42-62 25567057-4 2015 For the sediment extracts, a reduction of acetylcholinesterase activity to about 60% could only be shown for the Vering Canal sediment extracts; this could be correlated to high contents of acetylcholinesterase-inhibiting polycyclic aromatic hydrocarbons (PAHs) as identified by chemical analyses. Polycyclic Aromatic Hydrocarbons 222-254 acetylcholinesterase Danio rerio 190-210 25567057-4 2015 For the sediment extracts, a reduction of acetylcholinesterase activity to about 60% could only be shown for the Vering Canal sediment extracts; this could be correlated to high contents of acetylcholinesterase-inhibiting polycyclic aromatic hydrocarbons (PAHs) as identified by chemical analyses. Polycyclic Aromatic Hydrocarbons 256-260 acetylcholinesterase Danio rerio 42-62 25567057-4 2015 For the sediment extracts, a reduction of acetylcholinesterase activity to about 60% could only be shown for the Vering Canal sediment extracts; this could be correlated to high contents of acetylcholinesterase-inhibiting polycyclic aromatic hydrocarbons (PAHs) as identified by chemical analyses. Polycyclic Aromatic Hydrocarbons 256-260 acetylcholinesterase Danio rerio 190-210 26451632-0 2015 Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"". Polycyclic Aromatic Hydrocarbons 36-68 carboxylesterase 2 Homo sapiens 82-85 26451632-0 2015 Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"". Polycyclic Aromatic Hydrocarbons 36-68 carboxylesterase 2 Homo sapiens 192-195 26451632-0 2015 Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"". Polycyclic Aromatic Hydrocarbons 36-68 carboxylesterase 2 Homo sapiens 192-195 26451632-0 2015 Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"". Polycyclic Aromatic Hydrocarbons 36-67 carboxylesterase 2 Homo sapiens 82-85 26451632-0 2015 Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"". Polycyclic Aromatic Hydrocarbons 36-67 carboxylesterase 2 Homo sapiens 192-195 26451632-0 2015 Reply to "Comment on "Photolysis of Polycyclic Aromatic Hydrocarbons on Water and Ice Surfaces" and on "Nonchromophoric Organic Matter Suppresses Polycyclic Aromatic Hydrocarbon Photolysis in Ice and at Ice Surfaces"". Polycyclic Aromatic Hydrocarbons 36-67 carboxylesterase 2 Homo sapiens 192-195 26210589-6 2015 The risk assessment using international sediments quality guidelines and sediments quality criteria indicated that several PAHs, such as Nap, Flu, Phe, Ace, Acy and BghiP in most of the sites would potentially affect organisms in Yangpu Bay. Polycyclic Aromatic Hydrocarbons 123-127 angiotensin I converting enzyme Homo sapiens 152-155 24798859-0 2015 Regulation of p53-targeting microRNAs by polycyclic aromatic hydrocarbons: Implications in the etiology of multiple myeloma. Polycyclic Aromatic Hydrocarbons 41-73 tumor protein p53 Homo sapiens 14-17 24798859-9 2015 Collectively, these data implicate polycyclic aromatic hydrocarbons and AhR in the regulation of p53-targeting miRNAs in MM and identify a potential therapeutic and preventive agent to combat this deadly disease. Polycyclic Aromatic Hydrocarbons 35-67 tumor protein p53 Homo sapiens 97-100 26252339-1 2015 Polycyclic aromatic hydrocarbons (PAHs) and chlorinated PAHs (ClPAHs) are ubiquitous contaminants that bind to the aryl hydrocarbon receptor (AhR) and exhibit mutagenic potential. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 115-140 26252339-1 2015 Polycyclic aromatic hydrocarbons (PAHs) and chlorinated PAHs (ClPAHs) are ubiquitous contaminants that bind to the aryl hydrocarbon receptor (AhR) and exhibit mutagenic potential. Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Homo sapiens 142-145 26252339-1 2015 Polycyclic aromatic hydrocarbons (PAHs) and chlorinated PAHs (ClPAHs) are ubiquitous contaminants that bind to the aryl hydrocarbon receptor (AhR) and exhibit mutagenic potential. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 115-140 26252339-1 2015 Polycyclic aromatic hydrocarbons (PAHs) and chlorinated PAHs (ClPAHs) are ubiquitous contaminants that bind to the aryl hydrocarbon receptor (AhR) and exhibit mutagenic potential. Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Homo sapiens 142-145 26252339-1 2015 Polycyclic aromatic hydrocarbons (PAHs) and chlorinated PAHs (ClPAHs) are ubiquitous contaminants that bind to the aryl hydrocarbon receptor (AhR) and exhibit mutagenic potential. Polycyclic Aromatic Hydrocarbons 56-60 aryl hydrocarbon receptor Homo sapiens 115-140 26252339-1 2015 Polycyclic aromatic hydrocarbons (PAHs) and chlorinated PAHs (ClPAHs) are ubiquitous contaminants that bind to the aryl hydrocarbon receptor (AhR) and exhibit mutagenic potential. Polycyclic Aromatic Hydrocarbons 56-60 aryl hydrocarbon receptor Homo sapiens 142-145 25958359-1 2015 In the present work, we investigated the characteristics of polycyclic aromatic hydrocarbons (PAHs) and metal(loid)s in indoor/outdoor PM10, PM2.5, and PM1 in a retirement home and a school dormitory in Tehran from May 2012 to May 2013. Polycyclic Aromatic Hydrocarbons 60-92 transmembrane protein 11 Homo sapiens 135-138 25958359-1 2015 In the present work, we investigated the characteristics of polycyclic aromatic hydrocarbons (PAHs) and metal(loid)s in indoor/outdoor PM10, PM2.5, and PM1 in a retirement home and a school dormitory in Tehran from May 2012 to May 2013. Polycyclic Aromatic Hydrocarbons 94-98 transmembrane protein 11 Homo sapiens 135-138 26377484-5 2015 The results showed that the total polycyclic aromatic hydrocarbon content was more than two times higher in samples from the Health Canadian intense smoking regime than in samples from the International Standardization Organization smoking regime (1189.23 versus 2859.50 ng/cig, p < 0.05). Polycyclic Aromatic Hydrocarbons 34-65 fibronectin 1 Homo sapiens 274-277 26057998-6 2015 The highest concentrations of PAHs were present in the stormwater with the highest total suspended solids (TSS); the relative amount of the HMW PAHs was highest in the Particulate fractions (particles>0.7 mum). Polycyclic Aromatic Hydrocarbons 30-34 cilia and flagella associated protein 97 Homo sapiens 140-143 26277803-0 2015 Pyrolysis-gas chromatography-mass spectrometry with electron-ionization or resonance-enhanced-multi-photon-ionization for characterization of polycyclic aromatic hydrocarbons in the Baltic Sea. Polycyclic Aromatic Hydrocarbons 142-174 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 189-192 26277803-2 2015 This study investigates the origin of PAH, which is supposed to derive mainly from anthropogenic activities, and their alteration along the salinity gradient of the Baltic Sea. Polycyclic Aromatic Hydrocarbons 38-41 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 172-175 26277803-4 2015 Along the north-south transect of the Baltic Sea a slightly rising trend for PAH is visible. Polycyclic Aromatic Hydrocarbons 77-80 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 45-48 26351879-5 2015 Ship breaking activities likely act as atmospheric emission sources of PCBs, PAHs, and HCB, thus adding to the international emphasis on responsible recycling of ships. Polycyclic Aromatic Hydrocarbons 77-81 inositol polyphosphate-5-phosphatase D Homo sapiens 0-4 26301740-1 2015 OBJECTIVES: Within a New York City (NYC) birth cohort, we assessed the associations between polycyclic aromatic hydrocarbon (PAH) and other aromatic DNA adducts and brain derived neurotrophic factor (BDNF) concentrations in umbilical cord blood, and neurodevelopment at age 2 years and whether BDNF is a mediator of the associations between PAH/aromatic-DNA adducts and neurodevelopment. Polycyclic Aromatic Hydrocarbons 92-123 brain derived neurotrophic factor Homo sapiens 165-198 26301740-1 2015 OBJECTIVES: Within a New York City (NYC) birth cohort, we assessed the associations between polycyclic aromatic hydrocarbon (PAH) and other aromatic DNA adducts and brain derived neurotrophic factor (BDNF) concentrations in umbilical cord blood, and neurodevelopment at age 2 years and whether BDNF is a mediator of the associations between PAH/aromatic-DNA adducts and neurodevelopment. Polycyclic Aromatic Hydrocarbons 125-128 brain derived neurotrophic factor Homo sapiens 165-198 26301740-11 2015 CONCLUSIONS: The results at age 2 suggest that prenatal exposure to a spectrum of PAH/aromatic pollutants may adversely affect early neurodevelopment, in part by reducing BDNF levels during the fetal period. Polycyclic Aromatic Hydrocarbons 82-85 brain derived neurotrophic factor Homo sapiens 171-175 26341340-0 2015 Polycyclic aromatic hydrocarbons in sediments of China Sea. Polycyclic Aromatic Hydrocarbons 0-32 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 55-58 26341340-4 2015 PAH concentrations in China Sea sediments decreased from north to south due to the higher emissions in North China. Polycyclic Aromatic Hydrocarbons 0-3 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 28-31 25483919-1 2015 A structure of hexadecyl trimethyl ammonium bromide (CTAB) micelle-assisted reduced graphene oxide-Ag nanoparticle (rGO-AgNP) hybrids is designed and fabricated for SERS detection of nonpolar polycyclic aromatic hydrocarbons (PAHs), in which CTAB micelles act as the host material to capture PAH molecules. Polycyclic Aromatic Hydrocarbons 192-224 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 165-169 25483919-1 2015 A structure of hexadecyl trimethyl ammonium bromide (CTAB) micelle-assisted reduced graphene oxide-Ag nanoparticle (rGO-AgNP) hybrids is designed and fabricated for SERS detection of nonpolar polycyclic aromatic hydrocarbons (PAHs), in which CTAB micelles act as the host material to capture PAH molecules. Polycyclic Aromatic Hydrocarbons 226-230 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 165-169 25483919-1 2015 A structure of hexadecyl trimethyl ammonium bromide (CTAB) micelle-assisted reduced graphene oxide-Ag nanoparticle (rGO-AgNP) hybrids is designed and fabricated for SERS detection of nonpolar polycyclic aromatic hydrocarbons (PAHs), in which CTAB micelles act as the host material to capture PAH molecules. Polycyclic Aromatic Hydrocarbons 226-229 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 165-169 25956473-5 2015 We observed that COX-2 and AHR protein expression was increased while GSTM1 expression was decreased in cells exposed to DHA and PAHs. Polycyclic Aromatic Hydrocarbons 129-133 prostaglandin-endoperoxide synthase 2 Homo sapiens 17-22 26012583-1 2015 nov., a high molecular weight polycyclic aromatic hydrocarbon-degrading bacterium isolated from cattle pasture soil. Polycyclic Aromatic Hydrocarbons 30-61 cellular communication network factor 3 Bos taurus 0-3 26049101-0 2015 Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. Polycyclic Aromatic Hydrocarbons 23-54 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 0-19 26049101-0 2015 Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. Polycyclic Aromatic Hydrocarbons 23-54 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 198-204 26049101-0 2015 Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse. Polycyclic Aromatic Hydrocarbons 56-59 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 0-19 26265155-3 2015 This work presents an ultra-high performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry (UHPLC-APPI-MS/MS) method for simultaneous analysis of 20 PAHs and nine nitro-PAHs. Polycyclic Aromatic Hydrocarbons 187-191 amyloid beta precursor protein Homo sapiens 136-140 26265155-3 2015 This work presents an ultra-high performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry (UHPLC-APPI-MS/MS) method for simultaneous analysis of 20 PAHs and nine nitro-PAHs. Polycyclic Aromatic Hydrocarbons 207-211 amyloid beta precursor protein Homo sapiens 136-140 26265155-10 2015 This fast, sensitive, and reliable method is the first UHPLC-APPI-MS/MS method capable of simultaneously analyzing 29 environmentally and toxicologically important PAHs and nitro-PAHs. Polycyclic Aromatic Hydrocarbons 164-168 amyloid beta precursor protein Homo sapiens 61-65 26265155-10 2015 This fast, sensitive, and reliable method is the first UHPLC-APPI-MS/MS method capable of simultaneously analyzing 29 environmentally and toxicologically important PAHs and nitro-PAHs. Polycyclic Aromatic Hydrocarbons 179-183 amyloid beta precursor protein Homo sapiens 61-65 25711989-10 2015 The PAH formation was discussed based on the combination of our results and with respect to Phi settings. Polycyclic Aromatic Hydrocarbons 4-7 glucose-6-phosphate isomerase Homo sapiens 92-95 25903171-0 2015 Polycyclic aromatic hydrocarbons in the largest deepwater port of East China Sea: impact of port construction and operation. Polycyclic Aromatic Hydrocarbons 0-32 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 77-80 25909326-0 2015 Induction of c-Jun by air particulate matter (PM10) of Mexico city: Participation of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 85-117 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 13-18 25909326-1 2015 The carcinogenic potential of urban particulate matter (PM) has been partly attributed to polycyclic aromatic hydrocarbons (PAHs) content, which activates the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 90-122 aryl hydrocarbon receptor Homo sapiens 159-184 25909326-1 2015 The carcinogenic potential of urban particulate matter (PM) has been partly attributed to polycyclic aromatic hydrocarbons (PAHs) content, which activates the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 90-122 aryl hydrocarbon receptor Homo sapiens 186-189 25909326-1 2015 The carcinogenic potential of urban particulate matter (PM) has been partly attributed to polycyclic aromatic hydrocarbons (PAHs) content, which activates the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 124-128 aryl hydrocarbon receptor Homo sapiens 159-184 25909326-1 2015 The carcinogenic potential of urban particulate matter (PM) has been partly attributed to polycyclic aromatic hydrocarbons (PAHs) content, which activates the aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 124-128 aryl hydrocarbon receptor Homo sapiens 186-189 25616380-8 2015 Estimated carcinogenicity of PAHs in terms of BaPeq indicated that BaP was the principal PAH contributor in CC (70%). Polycyclic Aromatic Hydrocarbons 29-32 prohibitin 2 Homo sapiens 46-49 25956473-5 2015 We observed that COX-2 and AHR protein expression was increased while GSTM1 expression was decreased in cells exposed to DHA and PAHs. Polycyclic Aromatic Hydrocarbons 129-133 aryl hydrocarbon receptor Homo sapiens 27-30 25956473-5 2015 We observed that COX-2 and AHR protein expression was increased while GSTM1 expression was decreased in cells exposed to DHA and PAHs. Polycyclic Aromatic Hydrocarbons 129-133 glutathione S-transferase mu 1 Homo sapiens 70-75 25990285-1 2015 The toxicities of polycyclic aromatic hydrocarbons (PAHs) have been extensively explored due to their carcinogenic and mutagenic potency; however, little is known about the metabolic responses to chronic environmental PAH exposure among the general population. Polycyclic Aromatic Hydrocarbons 18-50 phenylalanine hydroxylase Homo sapiens 52-55 26082767-4 2015 In this review, we focus on the potential role of CYP pathway in polycyclic aromatic hydrocarbons (PAH), important constituents of cigarette smoke, mediated HIV pathogenesis. Polycyclic Aromatic Hydrocarbons 65-97 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 50-53 26082767-4 2015 In this review, we focus on the potential role of CYP pathway in polycyclic aromatic hydrocarbons (PAH), important constituents of cigarette smoke, mediated HIV pathogenesis. Polycyclic Aromatic Hydrocarbons 99-102 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 50-53 26082767-5 2015 More specifically, we will discuss the role of CYP1A1 and CYP1B1, which are the major PAH-activating CYP enzymes. Polycyclic Aromatic Hydrocarbons 86-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 47-53 26082767-5 2015 More specifically, we will discuss the role of CYP1A1 and CYP1B1, which are the major PAH-activating CYP enzymes. Polycyclic Aromatic Hydrocarbons 86-89 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 58-64 26082767-5 2015 More specifically, we will discuss the role of CYP1A1 and CYP1B1, which are the major PAH-activating CYP enzymes. Polycyclic Aromatic Hydrocarbons 86-89 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 47-50 26082767-7 2015 CSC contains PAH, which are known to be activated by CYP1A1 and CYP1B1 into procarcinogens/toxic metabolites. Polycyclic Aromatic Hydrocarbons 13-16 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 53-59 26082767-7 2015 CSC contains PAH, which are known to be activated by CYP1A1 and CYP1B1 into procarcinogens/toxic metabolites. Polycyclic Aromatic Hydrocarbons 13-16 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 64-70 25723716-5 2015 Phylogenetic analysis showed that all the PAH-ring hydroxylating dioxygenase gene sequences of Gram-negative bacteria (PAH-RHD[GN]) were closely related to nahAc, nagAc, nidA, and uncultured PAH-RHD genes. Polycyclic Aromatic Hydrocarbons 42-45 Rh blood group D antigen Homo sapiens 123-126 25723716-5 2015 Phylogenetic analysis showed that all the PAH-ring hydroxylating dioxygenase gene sequences of Gram-negative bacteria (PAH-RHD[GN]) were closely related to nahAc, nagAc, nidA, and uncultured PAH-RHD genes. Polycyclic Aromatic Hydrocarbons 42-45 Rh blood group D antigen Homo sapiens 195-198 25532870-1 2015 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates many of the toxic effects of dioxin-like compounds (DLCs) and some polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 160-192 aryl hydrocarbon receptor 1a Danio rerio 4-29 25532870-1 2015 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates many of the toxic effects of dioxin-like compounds (DLCs) and some polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 160-192 aryl hydrocarbon receptor 1a Danio rerio 31-34 25532870-1 2015 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates many of the toxic effects of dioxin-like compounds (DLCs) and some polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 194-198 aryl hydrocarbon receptor 1a Danio rerio 4-29 25532870-1 2015 The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates many of the toxic effects of dioxin-like compounds (DLCs) and some polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 194-198 aryl hydrocarbon receptor 1a Danio rerio 31-34 25156607-7 2015 It was shown that, the APEX1 148Glu allele was associated with significantly higher MN frequencies than 148Asp allele, with strongest associations among the highest PAH-exposure workers (P = 0.008). Polycyclic Aromatic Hydrocarbons 165-168 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 23-28 25156607-10 2015 This study showed evidence on interaction between APEX1 148Glu variant and cigarette smoking in increasing lung cancer susceptibility among male Chinese, which may be due to the synergistic effects of APEX1 148Glu and PAHs in increasing chromosome damage levels. Polycyclic Aromatic Hydrocarbons 218-222 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 50-55 25863370-9 2015 Because all other priority polycyclic aromatic hydrocarbons could not be electrochemically oxidized at 0.98 V, the electrochemical assay showed very high selectivity to BaP. Polycyclic Aromatic Hydrocarbons 27-59 prohibitin 2 Homo sapiens 169-172 26023933-5 2015 Epidermal growth factor, 12-O-tetradecanoylphorbol-13-acetate, thrombin receptor activating peptide-6 and lindane regulated GJIC through a MEK1/2-dependent mechanism that was independent of PC-PLC; whereas PAHs, DDT, PCB 153, dicumylperoxide and perfluorodecanoic acid inhibited GJIC through PC-PLC independent of Mek. Polycyclic Aromatic Hydrocarbons 206-210 mitogen activated protein kinase kinase 1 Rattus norvegicus 139-145 25582180-1 2015 Polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons (HAHs) develop various adverse effects through activation of an aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Rattus norvegicus 142-167 25582180-1 2015 Polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons (HAHs) develop various adverse effects through activation of an aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl hydrocarbon receptor Rattus norvegicus 169-172 25582180-1 2015 Polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons (HAHs) develop various adverse effects through activation of an aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Rattus norvegicus 142-167 25582180-1 2015 Polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic hydrocarbons (HAHs) develop various adverse effects through activation of an aryl hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 aryl hydrocarbon receptor Rattus norvegicus 169-172 25500124-5 2015 The principal identified AhR agonists included benzo[k]fluoranthene, indeno[1,2,3-c,d]pyrene, chrysene and several non-priority PAHs, including benzochrysenes and methylated PAHs. Polycyclic Aromatic Hydrocarbons 128-132 aryl hydrocarbon receptor Homo sapiens 25-28 25913077-10 2015 Lower IL-2 and IL-6 levels in treatment groups compared with controls suggest that PAHs cause overt immune inhibition. Polycyclic Aromatic Hydrocarbons 83-87 interleukin 2 Mus musculus 6-10 25913077-10 2015 Lower IL-2 and IL-6 levels in treatment groups compared with controls suggest that PAHs cause overt immune inhibition. Polycyclic Aromatic Hydrocarbons 83-87 interleukin 6 Mus musculus 15-19 25858839-1 2015 A polycyclic aromatic hydrocarbon-degrading bacterium designated strain Ca6, a member of the family Rhodocyclaceae and a representative of the uncharacterized pyrene group 1 (PG1), was isolated and its genome sequenced. Polycyclic Aromatic Hydrocarbons 2-33 carbonic anhydrase 6 Homo sapiens 72-75 25860963-0 2015 Polycyclic aromatic hydrocarbons reciprocally regulate IL-22 and IL-17 cytokines in peripheral blood mononuclear cells from both healthy and asthmatic subjects. Polycyclic Aromatic Hydrocarbons 0-32 interleukin 22 Homo sapiens 55-60 25860963-0 2015 Polycyclic aromatic hydrocarbons reciprocally regulate IL-22 and IL-17 cytokines in peripheral blood mononuclear cells from both healthy and asthmatic subjects. Polycyclic Aromatic Hydrocarbons 0-32 interleukin 17A Homo sapiens 65-70 25860963-2 2015 PAH can bind to the Aryl hydrocarbon Receptor (AhR), a transcription factor involved in Th17/Th22 type polarization. Polycyclic Aromatic Hydrocarbons 0-3 aryl hydrocarbon receptor Homo sapiens 20-45 25860963-2 2015 PAH can bind to the Aryl hydrocarbon Receptor (AhR), a transcription factor involved in Th17/Th22 type polarization. Polycyclic Aromatic Hydrocarbons 0-3 aryl hydrocarbon receptor Homo sapiens 47-50 25860963-5 2015 We hypothesized that PAH might affect, through their effects on AhR, IL-17 and IL-22 production in allergic asthmatics. Polycyclic Aromatic Hydrocarbons 21-24 aryl hydrocarbon receptor Homo sapiens 64-67 25860963-5 2015 We hypothesized that PAH might affect, through their effects on AhR, IL-17 and IL-22 production in allergic asthmatics. Polycyclic Aromatic Hydrocarbons 21-24 interleukin 17A Homo sapiens 69-74 25860963-5 2015 We hypothesized that PAH might affect, through their effects on AhR, IL-17 and IL-22 production in allergic asthmatics. Polycyclic Aromatic Hydrocarbons 21-24 interleukin 22 Homo sapiens 79-84 25860963-8 2015 Diesel exhaust particle (DEP)-PAH and Benzo[a]Pyrene (B[a]P) stimulation further increased IL-22 but decreased IL-17A production in both groups. Polycyclic Aromatic Hydrocarbons 30-33 interleukin 22 Homo sapiens 91-96 25860963-8 2015 Diesel exhaust particle (DEP)-PAH and Benzo[a]Pyrene (B[a]P) stimulation further increased IL-22 but decreased IL-17A production in both groups. Polycyclic Aromatic Hydrocarbons 30-33 interleukin 17A Homo sapiens 111-117 25860963-9 2015 The PAH-induced IL-22 levels in asthmatic patients were significantly higher than in healthy subjects. Polycyclic Aromatic Hydrocarbons 4-7 interleukin 22 Homo sapiens 16-21 25860963-10 2015 Among PBMCs, PAH-induced IL-22 expression originated principally from single IL-22- but not from IL-17- expressing CD4 T cells. Polycyclic Aromatic Hydrocarbons 13-16 interleukin 22 Homo sapiens 25-30 25860963-10 2015 Among PBMCs, PAH-induced IL-22 expression originated principally from single IL-22- but not from IL-17- expressing CD4 T cells. Polycyclic Aromatic Hydrocarbons 13-16 interleukin 22 Homo sapiens 77-82 25860963-10 2015 Among PBMCs, PAH-induced IL-22 expression originated principally from single IL-22- but not from IL-17- expressing CD4 T cells. Polycyclic Aromatic Hydrocarbons 13-16 interleukin 17A Homo sapiens 97-102 25732352-7 2015 Similar concentration patterns of PAHs with soot and 9,10-anthraquinone/anthracene (9,10-AQ/ANT) ratios all >2.0 suggest regional PAC sources. Polycyclic Aromatic Hydrocarbons 34-38 solute carrier family 25 member 6 Homo sapiens 92-95 25794985-1 2015 Dibenzo[a,l]pyrene (DBP) has been found to be the most potent carcinogen of the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 80-112 D-box binding PAR bZIP transcription factor Homo sapiens 20-23 25794985-1 2015 Dibenzo[a,l]pyrene (DBP) has been found to be the most potent carcinogen of the polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 114-118 D-box binding PAR bZIP transcription factor Homo sapiens 20-23 25500124-5 2015 The principal identified AhR agonists included benzo[k]fluoranthene, indeno[1,2,3-c,d]pyrene, chrysene and several non-priority PAHs, including benzochrysenes and methylated PAHs. Polycyclic Aromatic Hydrocarbons 174-178 aryl hydrocarbon receptor Homo sapiens 25-28 25803276-8 2015 This suggests that DEPe, which is enriched in known ligands of AhR like polycyclic aromatic hydrocarbons, alters drug transporter expression via activation of the AhR cascade. Polycyclic Aromatic Hydrocarbons 72-104 aryl hydrocarbon receptor Homo sapiens 63-66 25803276-8 2015 This suggests that DEPe, which is enriched in known ligands of AhR like polycyclic aromatic hydrocarbons, alters drug transporter expression via activation of the AhR cascade. Polycyclic Aromatic Hydrocarbons 72-104 aryl hydrocarbon receptor Homo sapiens 163-166 25706091-6 2015 This study is the first to use in vitro methods to rank the AHR-mediated potency of PAHs in birds. Polycyclic Aromatic Hydrocarbons 84-88 aryl hydrocarbon receptor 1 alpha Gallus gallus 60-63 25715055-0 2015 Aryl hydrocarbon receptor activation and developmental toxicity in zebrafish in response to soil extracts containing unsubstituted and oxygenated PAHs. Polycyclic Aromatic Hydrocarbons 146-150 aryl hydrocarbon receptor 1a Danio rerio 0-25 25715055-9 2015 Ahr2-knock-down was most effective with the PAH fraction of the WOOD extract and with the oxy-PAH fraction of the COKE extract. Polycyclic Aromatic Hydrocarbons 44-47 aryl hydrocarbon receptor 2 Danio rerio 0-4 25524617-2 2015 Pyrene, as a PAH, was covalently linked to carrier protein bovine serum albumin and ovalbumin. Polycyclic Aromatic Hydrocarbons 13-16 albumin Homo sapiens 66-79 25437952-7 2015 However, the rate of PAH weathering appears to have decreased significantly once the oil was buried within the partially-closed SRB environment. Polycyclic Aromatic Hydrocarbons 21-24 chaperonin containing TCP1 subunit 4 Homo sapiens 128-131 26261966-1 2015 Using density functional theory, a possible pathway of soot surface growth is studied in the low-temperature, postflame region in which spin-triplet polycyclic aromatic hydrocarbon (PAH) molecules with a small singlet-triplet energy gap react with unsaturated aliphatics such as acetylene via the carbon-addition-hydrogen-migration (CAHM) reaction. Polycyclic Aromatic Hydrocarbons 149-180 spindlin 1 Homo sapiens 136-140 26261966-1 2015 Using density functional theory, a possible pathway of soot surface growth is studied in the low-temperature, postflame region in which spin-triplet polycyclic aromatic hydrocarbon (PAH) molecules with a small singlet-triplet energy gap react with unsaturated aliphatics such as acetylene via the carbon-addition-hydrogen-migration (CAHM) reaction. Polycyclic Aromatic Hydrocarbons 182-185 spindlin 1 Homo sapiens 136-140 25048800-8 2015 RESULTS: We show that higher average PAH exposure was significantly associated with impaired Treg function and increased methylation in the forkhead box protein 3 (FOXP3) locus (P < 0.05), conditional on atopic status. Polycyclic Aromatic Hydrocarbons 37-40 forkhead box P3 Homo sapiens 140-162 25327512-2 2015 As the exhaust of biodiesel/diesel blends is composed of a combination of combustion products of polycyclic aromatic hydrocarbons and fatty acid methyl esters, we hypothesize that 50% biodiesel/diesel blend (BD50) exposure could induce harmful outcomes because of its ability to trigger oxidative damage. Polycyclic Aromatic Hydrocarbons 97-129 defensin beta 50 Mus musculus 208-212 25236802-4 2015 The present study investigated the abundances and diversities of soil n-alkane and PAH-degrading bacterial communities targeting both alkB and nah genes in two oil exploring areas at different geographic regions. Polycyclic Aromatic Hydrocarbons 83-86 alkB homolog 1, histone H2A dioxygenase Homo sapiens 134-138 24998225-3 2015 We monitored the 1-hydroxypyrene (1-OHP) as biomarkers of exposure to PAHs and its probable association with catalase (CAT), glutathione (GSH) glutathione peroxidase (GSHPx) activity as biomarkers of oxidative stress in selected cohorts from the city Lahore. Polycyclic Aromatic Hydrocarbons 70-74 catalase Homo sapiens 109-117 25231738-0 2015 Simulating the dynamics of polycyclic aromatic hydrocarbon (PAH) in contaminated soil through composting by COP-Compost model. Polycyclic Aromatic Hydrocarbons 27-58 caspase recruitment domain family member 16 Homo sapiens 108-111 25231738-0 2015 Simulating the dynamics of polycyclic aromatic hydrocarbon (PAH) in contaminated soil through composting by COP-Compost model. Polycyclic Aromatic Hydrocarbons 60-63 caspase recruitment domain family member 16 Homo sapiens 108-111 25231738-3 2015 The COP-Compost model was evaluated via composting experiments containing 16 US Environmental Protection Agency (USEPA) polycyclic aromatic hydrocarbons (PAHs) and the sorption coefficient (Kd) values of two types of OP: fluorenthene (FLT) and pyrene (PHE). Polycyclic Aromatic Hydrocarbons 120-152 caspase recruitment domain family member 16 Homo sapiens 4-7 25231738-3 2015 The COP-Compost model was evaluated via composting experiments containing 16 US Environmental Protection Agency (USEPA) polycyclic aromatic hydrocarbons (PAHs) and the sorption coefficient (Kd) values of two types of OP: fluorenthene (FLT) and pyrene (PHE). Polycyclic Aromatic Hydrocarbons 154-158 caspase recruitment domain family member 16 Homo sapiens 4-7 25412620-0 2015 AHR2-Mediated transcriptomic responses underlying the synergistic cardiac developmental toxicity of PAHs. Polycyclic Aromatic Hydrocarbons 100-104 aryl hydrocarbon receptor 2 Danio rerio 0-4 25412620-2 2015 The aryl hydrocarbon receptor (AHR) mediates the toxicity of some PAHs. Polycyclic Aromatic Hydrocarbons 66-70 aryl hydrocarbon receptor 1a Danio rerio 4-29 25412620-2 2015 The aryl hydrocarbon receptor (AHR) mediates the toxicity of some PAHs. Polycyclic Aromatic Hydrocarbons 66-70 aryl hydrocarbon receptor 1a Danio rerio 31-34 25412620-3 2015 Exposure to a simple PAH mixture during embryo development consisting of an AHR agonist (benzo(a)pyrene-BaP) with fluoranthene (FL), an inhibitor of cytochrome p450 1(CYP1)--a gene induced by AHR activation--results in cardiac deformities. Polycyclic Aromatic Hydrocarbons 21-24 cytochrome P450, family 1, subfamily A Danio rerio 149-175 25440895-4 2015 The ERL/ERM and TEL/PEL values showed that there was a moderate level of toxicity risk for some PAHs. Polycyclic Aromatic Hydrocarbons 96-100 ETS variant transcription factor 6 Homo sapiens 16-19 25410825-4 2015 A close inspection reveals that the six PF6(-) counterions of BlueCage(6+) occupy the cavity in a fleeting manner as a consequence of anion-pi interactions and, as a result, compete with the PAH guests. Polycyclic Aromatic Hydrocarbons 191-194 sperm associated antigen 17 Homo sapiens 40-43 25383696-7 2015 We found the AhR ligand activities of the above four BUVSs to be stable in the presence of CYP1A1; therefore, they have the potential to accumulate and exert potent physiological effects in humans, analogous to polycyclic aromatic hydrocarbons and dioxins, which are known stable and toxic ligands. Polycyclic Aromatic Hydrocarbons 211-243 aryl hydrocarbon receptor Homo sapiens 13-16 25268939-7 2015 Independently of GJIC modulation, or p38 activation, TNF-alpha potentiated the AhR-dependent proliferative effect of a model low-molecular-weight PAH, fluoranthene, on contact-inhibited cells. Polycyclic Aromatic Hydrocarbons 146-149 tumor necrosis factor Rattus norvegicus 53-62 25268939-7 2015 Independently of GJIC modulation, or p38 activation, TNF-alpha potentiated the AhR-dependent proliferative effect of a model low-molecular-weight PAH, fluoranthene, on contact-inhibited cells. Polycyclic Aromatic Hydrocarbons 146-149 aryl hydrocarbon receptor Rattus norvegicus 79-82 25854346-3 2015 Inhibition of the enzymes responsible for the bioactivation of this carcinogen, for example CYP1A1, the major enzyme required for polycyclic aromatic hydrocarbons (PAHs) bioactivation, is recognized as a chemoprevention strategy. Polycyclic Aromatic Hydrocarbons 130-162 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 92-98 25854346-3 2015 Inhibition of the enzymes responsible for the bioactivation of this carcinogen, for example CYP1A1, the major enzyme required for polycyclic aromatic hydrocarbons (PAHs) bioactivation, is recognized as a chemoprevention strategy. Polycyclic Aromatic Hydrocarbons 164-168 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 92-98 25315223-4 2015 Cyp1b1, a member of the cytochrome P450 1 subfamily, is responsible for the metabolism of a wide variety of halogenated and polycyclic aromatic hydrocarbons in diverse tissues. Polycyclic Aromatic Hydrocarbons 124-156 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 0-6 25048800-8 2015 RESULTS: We show that higher average PAH exposure was significantly associated with impaired Treg function and increased methylation in the forkhead box protein 3 (FOXP3) locus (P < 0.05), conditional on atopic status. Polycyclic Aromatic Hydrocarbons 37-40 forkhead box P3 Homo sapiens 164-169 25048800-11 2015 Protein expression of IL-10 decreased and IFN-gamma increased as the extent of PAH exposure increased. Polycyclic Aromatic Hydrocarbons 79-82 interleukin 10 Homo sapiens 22-27 25048800-11 2015 Protein expression of IL-10 decreased and IFN-gamma increased as the extent of PAH exposure increased. Polycyclic Aromatic Hydrocarbons 79-82 interferon gamma Homo sapiens 42-51 25048800-14 2015 CONCLUSIONS AND CLINICAL RELEVANCE: Collectively, these results demonstrate that increased ambient PAH exposure is associated with impaired systemic immunity and epigenetic modifications in a key locus involved in atopy: FOXP3, with a higher impact on atopic children. Polycyclic Aromatic Hydrocarbons 99-102 forkhead box P3 Homo sapiens 221-226 25460629-1 2015 BACKGROUND: Polycyclic aromatic hydrocarbons (PAH) are produced by the burning and processing of fuel oils, and have been associated with oxidant stress, insulin resistance and hypertension in adults. Polycyclic Aromatic Hydrocarbons 12-44 insulin Homo sapiens 154-161 25555259-0 2015 Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs. Polycyclic Aromatic Hydrocarbons 99-103 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 27-33 25555259-0 2015 Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs. Polycyclic Aromatic Hydrocarbons 99-103 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 38-44 25460629-1 2015 BACKGROUND: Polycyclic aromatic hydrocarbons (PAH) are produced by the burning and processing of fuel oils, and have been associated with oxidant stress, insulin resistance and hypertension in adults. Polycyclic Aromatic Hydrocarbons 46-49 insulin Homo sapiens 154-161 25347678-8 2014 FINDINGS: Offspring of dams exposed to greater PAH during gestation had increased weight, fat mass, as well as higher gene expression of PPAR gamma, C/EBP alpha, Cox2, FAS and adiponectin and lower DNA methylation of PPAR gamma. Polycyclic Aromatic Hydrocarbons 47-50 peroxisome proliferator activated receptor gamma Mus musculus 137-147 25555259-3 2015 The results revealed that TCDD induce Cyp1a1>Cyp1a2>Cyp1b1, while PAHs and PAH-containing environmental mixtures induce Cyp1a2>Cyp1a1>Cyp1b1 gene expression pattern. Polycyclic Aromatic Hydrocarbons 72-75 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 126-132 25555259-3 2015 The results revealed that TCDD induce Cyp1a1>Cyp1a2>Cyp1b1, while PAHs and PAH-containing environmental mixtures induce Cyp1a2>Cyp1a1>Cyp1b1 gene expression pattern. Polycyclic Aromatic Hydrocarbons 72-75 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 136-142 25555259-6 2015 These findings indicate that differential Cyp1a1 and Cyp1a2 expression in the H4IIE cells might be used for detection of PAHs in highly contaminated environmental mixtures, but not in low-concentration mixtures of these compounds. Polycyclic Aromatic Hydrocarbons 121-125 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 42-48 25555259-6 2015 These findings indicate that differential Cyp1a1 and Cyp1a2 expression in the H4IIE cells might be used for detection of PAHs in highly contaminated environmental mixtures, but not in low-concentration mixtures of these compounds. Polycyclic Aromatic Hydrocarbons 121-125 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 53-59 25522656-7 2015 RESULTS: PAH-DNA adduct levels in cord blood tend to be higher in the NTD group (28.5 per 10(8) nucleotides) compared with controls (19.7 per 10(8) nucleotides), although the difference was not statistically significant (P=0.377). Polycyclic Aromatic Hydrocarbons 9-12 fuzzy planar cell polarity protein Homo sapiens 70-73 25522656-8 2015 PAH-DNA adducts in cord tissue were significantly higher in the NTD group (24.6 per 10(6) nucleotides) than in the control group (15.3 per 10(6) nucleotides), P=0.010. Polycyclic Aromatic Hydrocarbons 0-3 fuzzy planar cell polarity protein Homo sapiens 64-67 25224398-0 2015 Stress signaling in response to polycyclic aromatic hydrocarbon exposure in Arabidopsis thaliana involves a nucleoside diphosphate kinase, NDPK-3. Polycyclic Aromatic Hydrocarbons 32-63 nucleoside diphosphate kinase 3 Arabidopsis thaliana 139-145 25224398-1 2015 MAIN CONCLUSION: The study is the first to reveal the proteomic response in plants to a single PAH stress, and indicates that NDPK3 is a positive regulator in the Arabidopsis response to phenanthrene stress. Polycyclic Aromatic Hydrocarbons 95-98 nucleoside diphosphate kinase 3 Arabidopsis thaliana 126-131 23712962-2 2014 The primary focus on the toxicity of PAHs is their ability to activate the aryl hydrocarbon receptor (AhR)-mediated pathway and lead to carcinogenesis in different organisms. Polycyclic Aromatic Hydrocarbons 37-41 aryl-hydrocarbon receptor Mus musculus 75-100 23712962-2 2014 The primary focus on the toxicity of PAHs is their ability to activate the aryl hydrocarbon receptor (AhR)-mediated pathway and lead to carcinogenesis in different organisms. Polycyclic Aromatic Hydrocarbons 37-41 aryl-hydrocarbon receptor Mus musculus 102-105 23712962-9 2014 Taken together, our findings suggested that acute exposure to 3MC altered the cellular redox balance in hepatocytes to trigger Nrf2-regulated antioxidant responses, which may represent an adaptive cell defense mechanism against the oxidative stress induced by PAHs. Polycyclic Aromatic Hydrocarbons 260-264 nuclear factor, erythroid derived 2, like 2 Mus musculus 127-131 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. Polycyclic Aromatic Hydrocarbons 118-150 NBL1, DAN family BMP antagonist Homo sapiens 93-96 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. Polycyclic Aromatic Hydrocarbons 118-150 neurofilament light chain Homo sapiens 238-241 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. Polycyclic Aromatic Hydrocarbons 118-150 neuropeptide Y Homo sapiens 248-251 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. Polycyclic Aromatic Hydrocarbons 152-156 NBL1, DAN family BMP antagonist Homo sapiens 93-96 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. Polycyclic Aromatic Hydrocarbons 152-156 neurofilament light chain Homo sapiens 238-241 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. Polycyclic Aromatic Hydrocarbons 152-156 neuropeptide Y Homo sapiens 248-251 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. Polycyclic Aromatic Hydrocarbons 152-155 NBL1, DAN family BMP antagonist Homo sapiens 93-96 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. Polycyclic Aromatic Hydrocarbons 152-155 neurofilament light chain Homo sapiens 238-241 25329713-3 2014 In previous studies, these two products were observed in the gas-phase reaction between N2O5/NO3/NO2 and their parent polycyclic aromatic hydrocarbons (PAHs), while the heterogeneous reaction generated other nitro-PAH isomers (1, 3, 7, 8-NFL and 1-NPY) (Atkinson et al. Polycyclic Aromatic Hydrocarbons 152-155 neuropeptide Y Homo sapiens 248-251 25159092-6 2014 CB7993113 directly bound both murine and human AHR and inhibited polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively. Polycyclic Aromatic Hydrocarbons 98-101 aryl hydrocarbon receptor Homo sapiens 47-50 24661458-0 2014 Distribution and sources of polycyclic aromatic hydrocarbons in the surface sediments of Gorgan Bay, Caspian Sea. Polycyclic Aromatic Hydrocarbons 28-60 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 109-112 25411724-1 2014 Cigarette smoke is a known source of exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs), especially benzo[a]pyrene (BaP). Polycyclic Aromatic Hydrocarbons 62-94 prohibitin 2 Homo sapiens 130-133 25411724-1 2014 Cigarette smoke is a known source of exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs), especially benzo[a]pyrene (BaP). Polycyclic Aromatic Hydrocarbons 96-100 prohibitin 2 Homo sapiens 130-133 25279998-5 2014 The human recombinant AKR1A1 and AKR1C1-AKR1C4 enzymes all catalyze the oxidation of PAH trans-dihydrodiols to PAH o-quinones. Polycyclic Aromatic Hydrocarbons 85-88 aldo-keto reductase family 1 member A1 Homo sapiens 22-28 25279998-5 2014 The human recombinant AKR1A1 and AKR1C1-AKR1C4 enzymes all catalyze the oxidation of PAH trans-dihydrodiols to PAH o-quinones. Polycyclic Aromatic Hydrocarbons 85-88 aldo-keto reductase family 1 member C1 Homo sapiens 33-46 24526112-4 2014 Gas chromatography with mass spectrometry was used to analyze PAHs in the collected TSP samples and the PAH metabolites, urinary 2-naphthol (2-NAP) and 1-hydroxypyrene (1-OHP), of the residents. Polycyclic Aromatic Hydrocarbons 62-65 thrombospondin 1 Homo sapiens 84-87 25129155-1 2014 Atmospheric polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) and exist in gas and particle phases, as well as dissolved or suspended in precipitation (fog or rain). Polycyclic Aromatic Hydrocarbons 12-44 zinc finger protein, FOG family member 1 Homo sapiens 220-223 25129155-1 2014 Atmospheric polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) are persistent organic pollutants (POPs) and exist in gas and particle phases, as well as dissolved or suspended in precipitation (fog or rain). Polycyclic Aromatic Hydrocarbons 46-50 zinc finger protein, FOG family member 1 Homo sapiens 220-223 25129155-4 2014 PAH compounds [especially of low molecular weight (LMW)] were universally found, but mainly in the fog-water samples. Polycyclic Aromatic Hydrocarbons 0-3 zinc finger protein, FOG family member 1 Homo sapiens 99-102 25129155-5 2014 The total PAH concentration in fog-water ranged from non-detected to 216 ng L(-1) (mean of 45 ng L(-1)), and was much higher in fall than in winter. Polycyclic Aromatic Hydrocarbons 10-13 zinc finger protein, FOG family member 1 Homo sapiens 31-34 25129155-6 2014 Total PAH levels in the rain and fog events varied from non-detected to 1272 and 33 ng L(-1) for, respectively, LMW and high molecular weight (HMW) PAHs. Polycyclic Aromatic Hydrocarbons 6-9 zinc finger protein, FOG family member 1 Homo sapiens 33-36 25347678-8 2014 FINDINGS: Offspring of dams exposed to greater PAH during gestation had increased weight, fat mass, as well as higher gene expression of PPAR gamma, C/EBP alpha, Cox2, FAS and adiponectin and lower DNA methylation of PPAR gamma. Polycyclic Aromatic Hydrocarbons 47-50 CCAAT/enhancer binding protein (C/EBP), alpha Mus musculus 149-160 25347678-8 2014 FINDINGS: Offspring of dams exposed to greater PAH during gestation had increased weight, fat mass, as well as higher gene expression of PPAR gamma, C/EBP alpha, Cox2, FAS and adiponectin and lower DNA methylation of PPAR gamma. Polycyclic Aromatic Hydrocarbons 47-50 cytochrome c oxidase II, mitochondrial Mus musculus 162-166 25347678-8 2014 FINDINGS: Offspring of dams exposed to greater PAH during gestation had increased weight, fat mass, as well as higher gene expression of PPAR gamma, C/EBP alpha, Cox2, FAS and adiponectin and lower DNA methylation of PPAR gamma. Polycyclic Aromatic Hydrocarbons 47-50 fatty acid synthase Mus musculus 168-171 25347678-8 2014 FINDINGS: Offspring of dams exposed to greater PAH during gestation had increased weight, fat mass, as well as higher gene expression of PPAR gamma, C/EBP alpha, Cox2, FAS and adiponectin and lower DNA methylation of PPAR gamma. Polycyclic Aromatic Hydrocarbons 47-50 peroxisome proliferator activated receptor gamma Mus musculus 217-227 25131419-0 2014 Vertical distribution and source identification of polycyclic aromatic hydrocarbons (PAHs) in southwest of the Caspian Sea: most petrogenic events during the late Little Ice Age. Polycyclic Aromatic Hydrocarbons 51-83 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 119-122 25131419-0 2014 Vertical distribution and source identification of polycyclic aromatic hydrocarbons (PAHs) in southwest of the Caspian Sea: most petrogenic events during the late Little Ice Age. Polycyclic Aromatic Hydrocarbons 85-89 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 119-122 25131419-4 2014 Simultaneity of distinct peaks of PAH fluxes before 1840 and Caspian Sea level high-stands during the Little Ice Age (LIA), revealed the high importance of this phenomenon in washing and transport of land-based oil pollution into the Caspian Sea. Polycyclic Aromatic Hydrocarbons 34-37 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 242-245 25324842-2 2014 The aryl hydrocarbon receptor (AHR) has long been studied by toxicologists as a ligand-activated transcription factor that is activated by dioxin and other environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 189-221 aryl-hydrocarbon receptor Mus musculus 4-29 25324842-2 2014 The aryl hydrocarbon receptor (AHR) has long been studied by toxicologists as a ligand-activated transcription factor that is activated by dioxin and other environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 189-221 aryl-hydrocarbon receptor Mus musculus 31-34 25324842-2 2014 The aryl hydrocarbon receptor (AHR) has long been studied by toxicologists as a ligand-activated transcription factor that is activated by dioxin and other environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 223-227 aryl-hydrocarbon receptor Mus musculus 4-29 25324842-2 2014 The aryl hydrocarbon receptor (AHR) has long been studied by toxicologists as a ligand-activated transcription factor that is activated by dioxin and other environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 223-227 aryl-hydrocarbon receptor Mus musculus 31-34 25110319-10 2014 The present study illustrated that ILN might downregulate PAH-induced expressions through antagonizing AhR translocation. Polycyclic Aromatic Hydrocarbons 58-61 aryl hydrocarbon receptor Homo sapiens 103-106 24910181-8 2014 The toxic equivalent concentrations of carcinogenic PAHs varied between 11 and 231 ng TEQ/g; higher total toxic equivalent concentrations values were found in the coastal areas of the Caspian Sea. Polycyclic Aromatic Hydrocarbons 52-56 S13 erythroblastosis (avian) oncogene homolog Homo sapiens 192-195 24862482-3 2014 As far as we know, this is the first time an O3/UV FBR has been explored for PAHs treatment. Polycyclic Aromatic Hydrocarbons 77-81 immunoglobulin kappa variable 2D-38 (pseudogene) Homo sapiens 45-54 25103078-2 2014 Glutathione S-transferase omega 1 (GSTO1) and sulfotransferase 1A1 (SULT1A1) have been reported to be associated with the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Polycyclic Aromatic Hydrocarbons 136-168 glutathione S-transferase omega 1 Homo sapiens 0-33 25103078-2 2014 Glutathione S-transferase omega 1 (GSTO1) and sulfotransferase 1A1 (SULT1A1) have been reported to be associated with the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Polycyclic Aromatic Hydrocarbons 136-168 glutathione S-transferase omega 1 Homo sapiens 35-40 25103078-2 2014 Glutathione S-transferase omega 1 (GSTO1) and sulfotransferase 1A1 (SULT1A1) have been reported to be associated with the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Polycyclic Aromatic Hydrocarbons 136-168 sulfotransferase family 1A member 1 Homo sapiens 46-66 25103078-2 2014 Glutathione S-transferase omega 1 (GSTO1) and sulfotransferase 1A1 (SULT1A1) have been reported to be associated with the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Polycyclic Aromatic Hydrocarbons 136-168 sulfotransferase family 1A member 1 Homo sapiens 68-75 25103078-2 2014 Glutathione S-transferase omega 1 (GSTO1) and sulfotransferase 1A1 (SULT1A1) have been reported to be associated with the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Polycyclic Aromatic Hydrocarbons 170-174 glutathione S-transferase omega 1 Homo sapiens 0-33 25103078-2 2014 Glutathione S-transferase omega 1 (GSTO1) and sulfotransferase 1A1 (SULT1A1) have been reported to be associated with the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Polycyclic Aromatic Hydrocarbons 170-174 glutathione S-transferase omega 1 Homo sapiens 35-40 25103078-2 2014 Glutathione S-transferase omega 1 (GSTO1) and sulfotransferase 1A1 (SULT1A1) have been reported to be associated with the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Polycyclic Aromatic Hydrocarbons 170-174 sulfotransferase family 1A member 1 Homo sapiens 46-66 25103078-2 2014 Glutathione S-transferase omega 1 (GSTO1) and sulfotransferase 1A1 (SULT1A1) have been reported to be associated with the metabolism of polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. Polycyclic Aromatic Hydrocarbons 170-174 sulfotransferase family 1A member 1 Homo sapiens 68-75 24522011-0 2014 Aryl hydrocarbon receptor mediated activities in road dust from a metropolitan area, Hanoi-Vietnam: contribution of polycyclic aromatic hydrocarbons (PAHs) and human risk assessment. Polycyclic Aromatic Hydrocarbons 116-148 aryl hydrocarbon receptor Homo sapiens 0-25 24522011-0 2014 Aryl hydrocarbon receptor mediated activities in road dust from a metropolitan area, Hanoi-Vietnam: contribution of polycyclic aromatic hydrocarbons (PAHs) and human risk assessment. Polycyclic Aromatic Hydrocarbons 150-154 aryl hydrocarbon receptor Homo sapiens 0-25 25343551-1 2014 AIMS AND BACKGROUND: Cytochrome P450 (CYP) 1A1 enzyme plays an important role in the metabolism of carcinogens, such as polycyclic aromatic hydrocarbons, nitroaromatics and arylamines. Polycyclic Aromatic Hydrocarbons 120-152 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 21-46 24548649-4 2014 The known aryl hydrocarbon receptor (AhR) agonists PAHs and PCBs were analyzed by HRGC/HRMS instrument. Polycyclic Aromatic Hydrocarbons 51-55 aryl hydrocarbon receptor Rattus norvegicus 10-35 24548649-4 2014 The known aryl hydrocarbon receptor (AhR) agonists PAHs and PCBs were analyzed by HRGC/HRMS instrument. Polycyclic Aromatic Hydrocarbons 51-55 aryl hydrocarbon receptor Rattus norvegicus 37-40 24811947-6 2014 The releases of IL-8 from A549 and TNF-alpha from J774A.1 were significantly correlated to PM size, Zeta potential, endotoxin, major metals, and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 145-177 C-X-C motif chemokine ligand 8 Homo sapiens 16-20 24811947-6 2014 The releases of IL-8 from A549 and TNF-alpha from J774A.1 were significantly correlated to PM size, Zeta potential, endotoxin, major metals, and polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 145-177 tumor necrosis factor Homo sapiens 35-44 24910982-4 2014 Nanomolar concentrations of PAHs in the extracts induced activation of MEK4 signaling with down-stream increased gene expression of several important stress response mediators. Polycyclic Aromatic Hydrocarbons 28-32 mitogen-activated protein kinase kinase 4 Homo sapiens 71-75 24910982-8 2014 Taken together, this is the first study showing the involvement of MEK4/JNK/AP-1 pathway in regulating the intracellular stress response after exposure to nanomolar levels of PAHs in environmental mixtures. Polycyclic Aromatic Hydrocarbons 175-179 mitogen-activated protein kinase kinase 4 Homo sapiens 67-71 24910982-8 2014 Taken together, this is the first study showing the involvement of MEK4/JNK/AP-1 pathway in regulating the intracellular stress response after exposure to nanomolar levels of PAHs in environmental mixtures. Polycyclic Aromatic Hydrocarbons 175-179 mitogen-activated protein kinase 8 Homo sapiens 72-75 24910982-8 2014 Taken together, this is the first study showing the involvement of MEK4/JNK/AP-1 pathway in regulating the intracellular stress response after exposure to nanomolar levels of PAHs in environmental mixtures. Polycyclic Aromatic Hydrocarbons 175-179 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 76-80 25007155-1 2014 BACKGROUND: Aryl hydrocarbon receptor (AhR) is classically known to be activated by xenobiotics such as dioxins and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 116-148 aryl hydrocarbon receptor Homo sapiens 12-37 25007155-1 2014 BACKGROUND: Aryl hydrocarbon receptor (AhR) is classically known to be activated by xenobiotics such as dioxins and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 116-148 aryl hydrocarbon receptor Homo sapiens 39-42 25007155-1 2014 BACKGROUND: Aryl hydrocarbon receptor (AhR) is classically known to be activated by xenobiotics such as dioxins and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 150-154 aryl hydrocarbon receptor Homo sapiens 12-37 25007155-1 2014 BACKGROUND: Aryl hydrocarbon receptor (AhR) is classically known to be activated by xenobiotics such as dioxins and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 150-154 aryl hydrocarbon receptor Homo sapiens 39-42 24639079-2 2014 Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 63-81 24837322-3 2014 The BaP played a dominant role for carcinogenic and mutagenic potencies of PAHs, although the IND showed the highest concentration level. Polycyclic Aromatic Hydrocarbons 75-79 prohibitin 2 Homo sapiens 4-7 24639079-2 2014 Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 83-89 24639079-2 2014 Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 92-98 24639079-2 2014 Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes. Polycyclic Aromatic Hydrocarbons 34-37 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 63-81 24639079-2 2014 Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes. Polycyclic Aromatic Hydrocarbons 34-37 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 83-89 24639079-2 2014 Polycyclic aromatic hydrocarbons (PAH) increased expression of cytochrome P4501A1 (CYP1A1), CYP1B1 and phase II xenobiotic metabolizing enzymes in wild-type skin and keratinocytes. Polycyclic Aromatic Hydrocarbons 34-37 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 92-98 24639079-4 2014 Pparbeta/delta-null keratinocytes exhibited decreased AHR occupancy and histone acetylation on the Cyp1a1 promoter in response to a PAH compared with wild-type keratinocytes. Polycyclic Aromatic Hydrocarbons 132-135 peroxisome proliferator activator receptor delta Mus musculus 0-8 24639079-4 2014 Pparbeta/delta-null keratinocytes exhibited decreased AHR occupancy and histone acetylation on the Cyp1a1 promoter in response to a PAH compared with wild-type keratinocytes. Polycyclic Aromatic Hydrocarbons 132-135 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 99-105 24639079-9 2014 The mechanisms underlying this PPARbeta/delta-dependent reduction of AHR signaling by PAH are not due to alterations in the expression of AHR auxiliary proteins, ligand binding or AHR nuclear translocation between genotypes, but are likely influenced by PPARbeta/delta-dependent demethylation of AHR target gene promoters including Cyp1a1 that reduces AHR accessibility as shown by reduced promoter occupancy. Polycyclic Aromatic Hydrocarbons 86-89 peroxisome proliferator activator receptor delta Mus musculus 31-39 24639079-9 2014 The mechanisms underlying this PPARbeta/delta-dependent reduction of AHR signaling by PAH are not due to alterations in the expression of AHR auxiliary proteins, ligand binding or AHR nuclear translocation between genotypes, but are likely influenced by PPARbeta/delta-dependent demethylation of AHR target gene promoters including Cyp1a1 that reduces AHR accessibility as shown by reduced promoter occupancy. Polycyclic Aromatic Hydrocarbons 86-89 aryl-hydrocarbon receptor Mus musculus 69-72 24639079-9 2014 The mechanisms underlying this PPARbeta/delta-dependent reduction of AHR signaling by PAH are not due to alterations in the expression of AHR auxiliary proteins, ligand binding or AHR nuclear translocation between genotypes, but are likely influenced by PPARbeta/delta-dependent demethylation of AHR target gene promoters including Cyp1a1 that reduces AHR accessibility as shown by reduced promoter occupancy. Polycyclic Aromatic Hydrocarbons 86-89 peroxisome proliferator activator receptor delta Mus musculus 254-262 24639079-9 2014 The mechanisms underlying this PPARbeta/delta-dependent reduction of AHR signaling by PAH are not due to alterations in the expression of AHR auxiliary proteins, ligand binding or AHR nuclear translocation between genotypes, but are likely influenced by PPARbeta/delta-dependent demethylation of AHR target gene promoters including Cyp1a1 that reduces AHR accessibility as shown by reduced promoter occupancy. Polycyclic Aromatic Hydrocarbons 86-89 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 332-338 24549985-1 2014 The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates immunosuppression caused by a variety of environmental contaminants, such as polycyclic aromatic hydrocarbons or dioxins. Polycyclic Aromatic Hydrocarbons 170-202 aryl hydrocarbon receptor Homo sapiens 4-29 24633190-4 2014 METHODS: We performed a two-stage study in healthy male coke oven workers to identify miRNAs associated with PAH exposures quantified using urinary monohydroxy-PAHs and plasma benzo[a]pyrene-r-7,t-8,c-10-tetrahydrotetrol-albumin (BPDE-Alb) adducts. Polycyclic Aromatic Hydrocarbons 109-112 albumin Homo sapiens 235-238 24902670-5 2014 Concentrations of total PAHs ranged from 2.5 mg/kg to 126 mg/kg of SRB. Polycyclic Aromatic Hydrocarbons 24-28 chaperonin containing TCP1 subunit 4 Homo sapiens 67-70 24837320-5 2014 The density of CLB also increased, but at a slower rate compared to AWB, which was attributed to the high concentration of alkylated polycyclic aromatic hydrocarbons in it, which are more resistant to weathering. Polycyclic Aromatic Hydrocarbons 133-165 citramalyl-CoA lyase Homo sapiens 15-18 24705959-5 2014 The selective retention behaviors of polycyclic aromatic hydrocarbons (PAHs), including some positional isomers, steroids, and nucleobases were investigated using the newly obtained Sil-poly(ImC18-AAL), and octadecyl silylated silica (ODS) was used as the reference column. Polycyclic Aromatic Hydrocarbons 37-69 STIL centriolar assembly protein Homo sapiens 182-185 24705959-5 2014 The selective retention behaviors of polycyclic aromatic hydrocarbons (PAHs), including some positional isomers, steroids, and nucleobases were investigated using the newly obtained Sil-poly(ImC18-AAL), and octadecyl silylated silica (ODS) was used as the reference column. Polycyclic Aromatic Hydrocarbons 71-75 STIL centriolar assembly protein Homo sapiens 182-185 24736433-1 2014 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (Hsp90), is a ligand-activated transcription factor that plays a role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 152-183 aryl hydrocarbon receptor Homo sapiens 4-29 24736433-1 2014 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (Hsp90), is a ligand-activated transcription factor that plays a role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 152-183 aryl hydrocarbon receptor Homo sapiens 31-34 24736433-1 2014 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (Hsp90), is a ligand-activated transcription factor that plays a role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 152-183 heat shock protein 90 alpha family class A member 1 Homo sapiens 57-78 24736433-1 2014 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (Hsp90), is a ligand-activated transcription factor that plays a role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 152-183 heat shock protein 90 alpha family class A member 1 Homo sapiens 80-85 24736433-1 2014 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (Hsp90), is a ligand-activated transcription factor that plays a role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 185-188 aryl hydrocarbon receptor Homo sapiens 4-29 24736433-1 2014 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (Hsp90), is a ligand-activated transcription factor that plays a role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 185-188 aryl hydrocarbon receptor Homo sapiens 31-34 24736433-1 2014 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (Hsp90), is a ligand-activated transcription factor that plays a role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 185-188 heat shock protein 90 alpha family class A member 1 Homo sapiens 57-78 24736433-1 2014 The aryl hydrocarbon receptor (AhR), a client protein of heat shock protein 90 (Hsp90), is a ligand-activated transcription factor that plays a role in polycyclic aromatic hydrocarbon (PAH)-induced carcinogenesis. Polycyclic Aromatic Hydrocarbons 185-188 heat shock protein 90 alpha family class A member 1 Homo sapiens 80-85 24736433-5 2014 The main objective of this study was to determine whether p53 modulated AhR-dependent gene expression and PAH metabolism. Polycyclic Aromatic Hydrocarbons 106-109 tumor protein p53 Homo sapiens 58-61 24736433-13 2014 Collectively, our results suggest that p53 affects AhR-dependent gene expression, PAH metabolism, and possibly carcinogenesis. Polycyclic Aromatic Hydrocarbons 82-85 tumor protein p53 Homo sapiens 39-42 24549985-1 2014 The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that mediates immunosuppression caused by a variety of environmental contaminants, such as polycyclic aromatic hydrocarbons or dioxins. Polycyclic Aromatic Hydrocarbons 170-202 aryl hydrocarbon receptor Homo sapiens 31-34 24646186-3 2014 Importantly, addition at C(1) was found to be barrierless via a van der Waals complex implying this mechanism can play a key role in forming methyl substituted PAHs in low temperature extreme environments such as the interstellar medium and hydrocarbon-rich atmospheres of planets and their moons in the outer Solar System. Polycyclic Aromatic Hydrocarbons 160-164 heterogeneous nuclear ribonucleoprotein C Homo sapiens 25-29 24727239-0 2014 Expression of microRNAs, CYP1A1 and CYP2B1 in the livers and ovaries of female rats treated with DDT and PAHs. Polycyclic Aromatic Hydrocarbons 105-109 cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus 36-42 24722336-0 2014 Association of plasma IL-6 and Hsp70 with HRV at different levels of PAHs metabolites. Polycyclic Aromatic Hydrocarbons 69-73 interleukin 6 Homo sapiens 22-26 24722336-7 2014 In particular, elevated IL-6 was associated in a dose-dependent manner with decreased TP and LF in the high-PAHs metabolites groups (all Ptrend<0.05), but not in the low-PAHs metabolites groups. Polycyclic Aromatic Hydrocarbons 108-112 interleukin 6 Homo sapiens 24-28 24722336-7 2014 In particular, elevated IL-6 was associated in a dose-dependent manner with decreased TP and LF in the high-PAHs metabolites groups (all Ptrend<0.05), but not in the low-PAHs metabolites groups. Polycyclic Aromatic Hydrocarbons 173-177 interleukin 6 Homo sapiens 24-28 24722336-9 2014 However, increased Hsp70 was significantly associated with elevated standard deviation of NN intervals (SDNN), TP and LF in the low-PAHs metabolites groups (all Ptrend<0.05). Polycyclic Aromatic Hydrocarbons 132-136 heat shock protein family A (Hsp70) member 4 Homo sapiens 19-24 24722336-10 2014 We also observed that both IL-6 and Hsp70 significantly interacted with multiple PAHs metabolites in relation to HRV. Polycyclic Aromatic Hydrocarbons 81-85 interleukin 6 Homo sapiens 27-31 24722336-10 2014 We also observed that both IL-6 and Hsp70 significantly interacted with multiple PAHs metabolites in relation to HRV. Polycyclic Aromatic Hydrocarbons 81-85 heat shock protein family A (Hsp70) member 4 Homo sapiens 36-41 24722336-11 2014 CONCLUSIONS: In coke oven workers, increased IL-6 was associated with a dose-response decreased HRV in the high-PAHs metabolites groups, whereas increase of Hsp70 can result in significant dose-related increase in HRV in the low-PAHs metabolites groups. Polycyclic Aromatic Hydrocarbons 112-116 interleukin 6 Homo sapiens 45-49 24722336-11 2014 CONCLUSIONS: In coke oven workers, increased IL-6 was associated with a dose-response decreased HRV in the high-PAHs metabolites groups, whereas increase of Hsp70 can result in significant dose-related increase in HRV in the low-PAHs metabolites groups. Polycyclic Aromatic Hydrocarbons 229-233 interleukin 6 Homo sapiens 45-49 24722336-11 2014 CONCLUSIONS: In coke oven workers, increased IL-6 was associated with a dose-response decreased HRV in the high-PAHs metabolites groups, whereas increase of Hsp70 can result in significant dose-related increase in HRV in the low-PAHs metabolites groups. Polycyclic Aromatic Hydrocarbons 229-233 heat shock protein family A (Hsp70) member 4 Homo sapiens 157-162 24497629-0 2014 Mitochondrial targeting of cytochrome P450 (CYP) 1B1 and its role in polycyclic aromatic hydrocarbon-induced mitochondrial dysfunction. Polycyclic Aromatic Hydrocarbons 69-100 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 27-52 24497629-1 2014 We report that polycyclic aromatic hydrocarbon (PAH)-inducible CYP1B1 is targeted to mitochondria by sequence-specific cleavage at the N terminus by a cytosolic Ser protease (polyserase 1) to activate the cryptic internal signal. Polycyclic Aromatic Hydrocarbons 15-46 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 63-69 24497629-1 2014 We report that polycyclic aromatic hydrocarbon (PAH)-inducible CYP1B1 is targeted to mitochondria by sequence-specific cleavage at the N terminus by a cytosolic Ser protease (polyserase 1) to activate the cryptic internal signal. Polycyclic Aromatic Hydrocarbons 15-46 transmembrane protease, serine 9 Mus musculus 175-187 24497629-1 2014 We report that polycyclic aromatic hydrocarbon (PAH)-inducible CYP1B1 is targeted to mitochondria by sequence-specific cleavage at the N terminus by a cytosolic Ser protease (polyserase 1) to activate the cryptic internal signal. Polycyclic Aromatic Hydrocarbons 48-51 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 63-69 24497629-1 2014 We report that polycyclic aromatic hydrocarbon (PAH)-inducible CYP1B1 is targeted to mitochondria by sequence-specific cleavage at the N terminus by a cytosolic Ser protease (polyserase 1) to activate the cryptic internal signal. Polycyclic Aromatic Hydrocarbons 48-51 transmembrane protease, serine 9 Mus musculus 175-187 24497629-7 2014 These results confirm a role for CYP1B1 in inducing PAH-mediated mitochondrial dysfunction. Polycyclic Aromatic Hydrocarbons 52-55 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 33-39 24497629-9 2014 Our results not only show conservation of the endoprotease cleavage mechanism for mitochondrial import of family 1 CYPs but also reveal a direct role for mitochondrial CYP1B1 in PAH-mediated oxidative and chemical damage to mitochondria. Polycyclic Aromatic Hydrocarbons 178-181 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 168-174 24408822-4 2014 Unlike the parent, unsubstituted PAHs, oxidation of methylated PAHs seemed to increase the AhR-mediated potency of the compounds, with 2-methylanthracene-9,10-dione being almost 2 times more potent than 2-methylanthracene. Polycyclic Aromatic Hydrocarbons 63-67 aryl hydrocarbon receptor Homo sapiens 91-94 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Polycyclic Aromatic Hydrocarbons 36-67 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-141 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Polycyclic Aromatic Hydrocarbons 36-67 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Polycyclic Aromatic Hydrocarbons 36-67 aryl hydrocarbon receptor Homo sapiens 168-193 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Polycyclic Aromatic Hydrocarbons 36-67 aryl hydrocarbon receptor Homo sapiens 195-198 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Polycyclic Aromatic Hydrocarbons 69-72 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 123-141 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Polycyclic Aromatic Hydrocarbons 69-72 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 143-149 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Polycyclic Aromatic Hydrocarbons 69-72 aryl hydrocarbon receptor Homo sapiens 168-193 24588654-1 2014 UNLABELLED: Benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH), is an environmental contaminant that can induce cytochrome P4501A1 (CYP1A1) upregulation via aryl hydrocarbon receptor (AhR) activation and provoke inflammation. Polycyclic Aromatic Hydrocarbons 69-72 aryl hydrocarbon receptor Homo sapiens 195-198 23994691-6 2014 This was discovered by correlation between the depurinating adducts formed in mouse skin by treatment with benzo[a]pyrene, dibenzo[a,l]pyrene or 7,12-dimethylbenz[a]anthracene and the site of mutations in the Harvey-ras oncogene in mouse skin papillomas initiated by one of these PAH. Polycyclic Aromatic Hydrocarbons 280-283 Harvey rat sarcoma virus oncogene Mus musculus 209-219 24486495-4 2014 Toxicological evaluation by TCA and TEQ methods, conducted for the first time in Venice air samples, identified BaP, PCB-126 and PCB-169 as the most important contributors to the total carcinogenic activity of PAHs and the total dioxin-like activity of PCBs and PCNs. Polycyclic Aromatic Hydrocarbons 210-214 pyruvate carboxylase Homo sapiens 117-120 24486495-4 2014 Toxicological evaluation by TCA and TEQ methods, conducted for the first time in Venice air samples, identified BaP, PCB-126 and PCB-169 as the most important contributors to the total carcinogenic activity of PAHs and the total dioxin-like activity of PCBs and PCNs. Polycyclic Aromatic Hydrocarbons 210-214 pyruvate carboxylase Homo sapiens 129-132 24594813-8 2014 At least 90% polycyclic aromatic hydrocarbons (PAHs) were desorbed from a polyacrylonitrile (PAN)/C18 bonded fuse silica fiber in 30s. Polycyclic Aromatic Hydrocarbons 13-45 Bardet-Biedl syndrome 9 Homo sapiens 98-101 24594813-8 2014 At least 90% polycyclic aromatic hydrocarbons (PAHs) were desorbed from a polyacrylonitrile (PAN)/C18 bonded fuse silica fiber in 30s. Polycyclic Aromatic Hydrocarbons 47-51 Bardet-Biedl syndrome 9 Homo sapiens 98-101 24647528-10 2014 In the two cohorts combined, PAH-DNA adducts were inversely associated with mBDNF as well as scores for motor (p = 0.05), adaptive (p = 0.022), and average (p = 0.014) DQ. Polycyclic Aromatic Hydrocarbons 29-32 brain derived neurotrophic factor Mus musculus 76-81 24681596-8 2014 Taken together, ours findings suggested that the expression of AHR- and antioxidant-related genes in a tissue-specific manner with or without treatment of a PAH. Polycyclic Aromatic Hydrocarbons 157-160 aryl-hydrocarbon receptor Mus musculus 63-66 24847427-1 2014 OBJECTIVE(S): Cytochrome P-450 1A1 is an important enzyme in the first phase of the metabolism of some carcinogens such as polycyclic aromatic hydrocarbons (PAHs), as well as estrogen. Polycyclic Aromatic Hydrocarbons 123-155 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-34 24847427-1 2014 OBJECTIVE(S): Cytochrome P-450 1A1 is an important enzyme in the first phase of the metabolism of some carcinogens such as polycyclic aromatic hydrocarbons (PAHs), as well as estrogen. Polycyclic Aromatic Hydrocarbons 157-161 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-34 24287212-1 2014 Polycyclic aromatic hydrocarbons (PAHs) activate aryl-hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl-hydrocarbon receptor Mus musculus 49-74 24287212-1 2014 Polycyclic aromatic hydrocarbons (PAHs) activate aryl-hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 0-32 aryl-hydrocarbon receptor Mus musculus 76-79 24287212-1 2014 Polycyclic aromatic hydrocarbons (PAHs) activate aryl-hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 aryl-hydrocarbon receptor Mus musculus 49-74 24287212-1 2014 Polycyclic aromatic hydrocarbons (PAHs) activate aryl-hydrocarbon receptor (AhR). Polycyclic Aromatic Hydrocarbons 34-38 aryl-hydrocarbon receptor Mus musculus 76-79 24287212-2 2014 Because PAHs are known as a risk factor for allergic diseases, PAH-induced AhR activation is expected to be involved in the development of the pathology. Polycyclic Aromatic Hydrocarbons 8-11 aryl-hydrocarbon receptor Mus musculus 75-78 24586676-0 2014 GSTT1 deletion is related to polycyclic aromatic hydrocarbons-induced DNA damage and lymphoma progression. Polycyclic Aromatic Hydrocarbons 29-61 glutathione S-transferase theta 1 Homo sapiens 0-5 24586676-3 2014 Here we investigated the molecular connection of the genetic polymorphism of GSTT1 to the response of lymphocytes to polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 117-149 glutathione S-transferase theta 1 Homo sapiens 77-82 24586676-3 2014 Here we investigated the molecular connection of the genetic polymorphism of GSTT1 to the response of lymphocytes to polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 151-154 glutathione S-transferase theta 1 Homo sapiens 77-82 24586676-6 2014 Mimicking environmental exposure using long-term repeat culture with low-dose PAH metabolite Hydroquinone, malignant B- and T-lymphocytes presented increased DNA damage, pCHK1/MYC expression and cell proliferation, which were counteracted by ectopic expression of GSTT1. Polycyclic Aromatic Hydrocarbons 78-81 MYC proto-oncogene, bHLH transcription factor Homo sapiens 176-179 24586676-6 2014 Mimicking environmental exposure using long-term repeat culture with low-dose PAH metabolite Hydroquinone, malignant B- and T-lymphocytes presented increased DNA damage, pCHK1/MYC expression and cell proliferation, which were counteracted by ectopic expression of GSTT1. Polycyclic Aromatic Hydrocarbons 78-81 glutathione S-transferase theta 1 Homo sapiens 264-269 24586676-8 2014 In non-neoplastic situation, when zebrafish was exposed to PAH Benzo(a)pyrene, molecular silencing of gstt1 enhanced the proliferation of normal lymphocytes and upregulated myca expression. Polycyclic Aromatic Hydrocarbons 59-62 glutathione S-transferase theta 1a Danio rerio 102-107 24586676-9 2014 Collectively, these findings suggested that GSTT1 deletion is related to genetic predisposition to lymphoma, particularly interacting with environmental pollutants containing PAH. Polycyclic Aromatic Hydrocarbons 175-178 glutathione S-transferase theta 1 Homo sapiens 44-49 24390408-2 2014 In the present study, conditions for specific analysis of stable adducts to SA formed from carcinogenic polycyclic aromatic hydrocarbons (PAH) were evaluated in order to achieve a sensitive and reproducible quantitative method. Polycyclic Aromatic Hydrocarbons 104-136 albumin Homo sapiens 76-78 24213842-9 2014 The known AhR agonists polycyclic aromatic hydrocarbon, polychlorinated biphenyl, and PCDD/F only explained up to 8 % of the more persistent AhR agonist activity in the samples, which suggests that unidentified AhR-active compounds represented a great proportion of the TCDD EQ in sediments from TGR. Polycyclic Aromatic Hydrocarbons 23-54 aryl hydrocarbon receptor Rattus norvegicus 10-13 24213842-9 2014 The known AhR agonists polycyclic aromatic hydrocarbon, polychlorinated biphenyl, and PCDD/F only explained up to 8 % of the more persistent AhR agonist activity in the samples, which suggests that unidentified AhR-active compounds represented a great proportion of the TCDD EQ in sediments from TGR. Polycyclic Aromatic Hydrocarbons 23-54 aryl hydrocarbon receptor Rattus norvegicus 141-144 24213842-9 2014 The known AhR agonists polycyclic aromatic hydrocarbon, polychlorinated biphenyl, and PCDD/F only explained up to 8 % of the more persistent AhR agonist activity in the samples, which suggests that unidentified AhR-active compounds represented a great proportion of the TCDD EQ in sediments from TGR. Polycyclic Aromatic Hydrocarbons 23-54 aryl hydrocarbon receptor Rattus norvegicus 141-144 23972323-1 2014 Forest fires are known as an important natural source of polycyclic aromatic hydrocarbons (PAHs), but time trends of PAH levels and patterns in various environmental compartments after forest fires have not been thoroughly studied yet. Polycyclic Aromatic Hydrocarbons 57-89 phenylalanine hydroxylase Homo sapiens 91-94 24001685-1 2014 The objective was to quantitatively understand the impacts of climate change (CC) under the A1B scenario on the contamination levels of 11 polycyclic aromatic hydrocarbons (PAHs) from pyrogenic sources in the environmental media based on model prediction. Polycyclic Aromatic Hydrocarbons 139-171 alpha-1-B glycoprotein Homo sapiens 92-95 24001685-1 2014 The objective was to quantitatively understand the impacts of climate change (CC) under the A1B scenario on the contamination levels of 11 polycyclic aromatic hydrocarbons (PAHs) from pyrogenic sources in the environmental media based on model prediction. Polycyclic Aromatic Hydrocarbons 173-177 alpha-1-B glycoprotein Homo sapiens 92-95 24338968-8 2014 Using our optimized method, stable carbon isotope ratios can be reliably measured in samples with concentrations of PAHs down to 0.05-0.1 ng muL(-1). Polycyclic Aromatic Hydrocarbons 116-120 mitochondrial E3 ubiquitin protein ligase 1 Homo sapiens 141-147 24615030-1 2014 Microsomal epoxide hydrolase 1 (EPHX1) is an important biological phase II metabolic enzyme that is extensively involved in the metabolism of diverse environmental carcinogens such as polycyclic aromatic hydrocarbons and heterocyclic amines. Polycyclic Aromatic Hydrocarbons 184-216 epoxide hydrolase 1 Homo sapiens 32-37 24246761-2 2014 We previously showed that the PAH prototype, benzo[a]pyrene (B[a]P), triggers apoptosis via DNA damage-induced p53 activation (genotoxic pathway) and via remodeling of the membrane cholesterol-rich microdomains called lipid rafts, leading to changes in pH homeostasis (non-genotoxic pathway). Polycyclic Aromatic Hydrocarbons 30-33 tumor protein p53 Homo sapiens 111-114 24304651-2 2014 Gel-forming compounds-grafted silica particles (Sil-G1 and Sil-G2) were then applied for the liquid chromatographic separation of shape-constrained isomers of polycyclic aromatic hydrocarbons (PAHs) and tocopherols as stationary phases. Polycyclic Aromatic Hydrocarbons 159-191 STIL centriolar assembly protein Homo sapiens 48-51 24304651-2 2014 Gel-forming compounds-grafted silica particles (Sil-G1 and Sil-G2) were then applied for the liquid chromatographic separation of shape-constrained isomers of polycyclic aromatic hydrocarbons (PAHs) and tocopherols as stationary phases. Polycyclic Aromatic Hydrocarbons 159-191 STIL centriolar assembly protein Homo sapiens 59-62 24304651-2 2014 Gel-forming compounds-grafted silica particles (Sil-G1 and Sil-G2) were then applied for the liquid chromatographic separation of shape-constrained isomers of polycyclic aromatic hydrocarbons (PAHs) and tocopherols as stationary phases. Polycyclic Aromatic Hydrocarbons 193-197 STIL centriolar assembly protein Homo sapiens 48-51 24761888-0 2014 Impact of AhR, CYP1A1 and GSTM1 genetic polymorphisms on TP53 R273G mutations in individuals exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 104-136 aryl hydrocarbon receptor Homo sapiens 10-13 24761888-0 2014 Impact of AhR, CYP1A1 and GSTM1 genetic polymorphisms on TP53 R273G mutations in individuals exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 104-136 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-21 24761888-0 2014 Impact of AhR, CYP1A1 and GSTM1 genetic polymorphisms on TP53 R273G mutations in individuals exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 104-136 glutathione S-transferase mu 1 Homo sapiens 26-31 24761888-0 2014 Impact of AhR, CYP1A1 and GSTM1 genetic polymorphisms on TP53 R273G mutations in individuals exposed to polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 104-136 tumor protein p53 Homo sapiens 57-61 24761888-1 2014 This study was to undertaken to investigate the impacts of AhR, CYP1A1, GSTM1 genetic polymorphisms on the R273G mutation in exon 8 of the tumor suppressor p53 gene (TP53) among polycyclic aromatic hydrocarbons (PAHs) exposed to coke-oven workers. Polycyclic Aromatic Hydrocarbons 178-210 aryl hydrocarbon receptor Homo sapiens 59-62 24761888-1 2014 This study was to undertaken to investigate the impacts of AhR, CYP1A1, GSTM1 genetic polymorphisms on the R273G mutation in exon 8 of the tumor suppressor p53 gene (TP53) among polycyclic aromatic hydrocarbons (PAHs) exposed to coke-oven workers. Polycyclic Aromatic Hydrocarbons 178-210 glutathione S-transferase mu 1 Homo sapiens 72-77 24761888-1 2014 This study was to undertaken to investigate the impacts of AhR, CYP1A1, GSTM1 genetic polymorphisms on the R273G mutation in exon 8 of the tumor suppressor p53 gene (TP53) among polycyclic aromatic hydrocarbons (PAHs) exposed to coke-oven workers. Polycyclic Aromatic Hydrocarbons 178-210 tumor protein p53 Homo sapiens 156-159 24761888-1 2014 This study was to undertaken to investigate the impacts of AhR, CYP1A1, GSTM1 genetic polymorphisms on the R273G mutation in exon 8 of the tumor suppressor p53 gene (TP53) among polycyclic aromatic hydrocarbons (PAHs) exposed to coke-oven workers. Polycyclic Aromatic Hydrocarbons 178-210 tumor protein p53 Homo sapiens 166-170 24761888-1 2014 This study was to undertaken to investigate the impacts of AhR, CYP1A1, GSTM1 genetic polymorphisms on the R273G mutation in exon 8 of the tumor suppressor p53 gene (TP53) among polycyclic aromatic hydrocarbons (PAHs) exposed to coke-oven workers. Polycyclic Aromatic Hydrocarbons 212-216 tumor protein p53 Homo sapiens 156-159 24761888-1 2014 This study was to undertaken to investigate the impacts of AhR, CYP1A1, GSTM1 genetic polymorphisms on the R273G mutation in exon 8 of the tumor suppressor p53 gene (TP53) among polycyclic aromatic hydrocarbons (PAHs) exposed to coke-oven workers. Polycyclic Aromatic Hydrocarbons 212-216 tumor protein p53 Homo sapiens 166-170 24761888-7 2014 Our findings indicated that polymorphisms of PAH metabolic genes, such as AhR, CYP1A1, GSTM1 polymorphisms may interact with p53 genetic variants and may contribute to PAH related cancers. Polycyclic Aromatic Hydrocarbons 45-48 aryl hydrocarbon receptor Homo sapiens 74-77 24761888-7 2014 Our findings indicated that polymorphisms of PAH metabolic genes, such as AhR, CYP1A1, GSTM1 polymorphisms may interact with p53 genetic variants and may contribute to PAH related cancers. Polycyclic Aromatic Hydrocarbons 45-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-85 24761888-7 2014 Our findings indicated that polymorphisms of PAH metabolic genes, such as AhR, CYP1A1, GSTM1 polymorphisms may interact with p53 genetic variants and may contribute to PAH related cancers. Polycyclic Aromatic Hydrocarbons 45-48 glutathione S-transferase mu 1 Homo sapiens 87-92 24761888-7 2014 Our findings indicated that polymorphisms of PAH metabolic genes, such as AhR, CYP1A1, GSTM1 polymorphisms may interact with p53 genetic variants and may contribute to PAH related cancers. Polycyclic Aromatic Hydrocarbons 45-48 tumor protein p53 Homo sapiens 125-128 24761888-7 2014 Our findings indicated that polymorphisms of PAH metabolic genes, such as AhR, CYP1A1, GSTM1 polymorphisms may interact with p53 genetic variants and may contribute to PAH related cancers. Polycyclic Aromatic Hydrocarbons 168-171 aryl hydrocarbon receptor Homo sapiens 74-77 24761888-7 2014 Our findings indicated that polymorphisms of PAH metabolic genes, such as AhR, CYP1A1, GSTM1 polymorphisms may interact with p53 genetic variants and may contribute to PAH related cancers. Polycyclic Aromatic Hydrocarbons 168-171 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-85 24761888-7 2014 Our findings indicated that polymorphisms of PAH metabolic genes, such as AhR, CYP1A1, GSTM1 polymorphisms may interact with p53 genetic variants and may contribute to PAH related cancers. Polycyclic Aromatic Hydrocarbons 168-171 glutathione S-transferase mu 1 Homo sapiens 87-92 24761888-7 2014 Our findings indicated that polymorphisms of PAH metabolic genes, such as AhR, CYP1A1, GSTM1 polymorphisms may interact with p53 genetic variants and may contribute to PAH related cancers. Polycyclic Aromatic Hydrocarbons 168-171 tumor protein p53 Homo sapiens 125-128 24390408-2 2014 In the present study, conditions for specific analysis of stable adducts to SA formed from carcinogenic polycyclic aromatic hydrocarbons (PAH) were evaluated in order to achieve a sensitive and reproducible quantitative method. Polycyclic Aromatic Hydrocarbons 138-141 albumin Homo sapiens 76-78 25114913-0 2014 Profiling of biomarkers for the exposure of polycyclic aromatic hydrocarbons: lamin-A/C isoform 3, poly[ADP-ribose] polymerase 1, and mitochondria copy number are identified as universal biomarkers. Polycyclic Aromatic Hydrocarbons 44-76 lamin A Danio rerio 78-97 24177223-8 2014 We found significant interactions between maternal PAH exposure and haplotype on cord B[a]P-DNA adducts in the following genes: maternal CYP1B1, XRCC1 and GSTM3, and newborn CYP1A2 and XRCC1 in African-Americans; and maternal XRCC1 and newborn NQO1 in Dominicans. Polycyclic Aromatic Hydrocarbons 51-54 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 137-143 24177223-8 2014 We found significant interactions between maternal PAH exposure and haplotype on cord B[a]P-DNA adducts in the following genes: maternal CYP1B1, XRCC1 and GSTM3, and newborn CYP1A2 and XRCC1 in African-Americans; and maternal XRCC1 and newborn NQO1 in Dominicans. Polycyclic Aromatic Hydrocarbons 51-54 X-ray repair cross complementing 1 Homo sapiens 145-150 24177223-8 2014 We found significant interactions between maternal PAH exposure and haplotype on cord B[a]P-DNA adducts in the following genes: maternal CYP1B1, XRCC1 and GSTM3, and newborn CYP1A2 and XRCC1 in African-Americans; and maternal XRCC1 and newborn NQO1 in Dominicans. Polycyclic Aromatic Hydrocarbons 51-54 glutathione S-transferase mu 3 Homo sapiens 155-160 24177223-8 2014 We found significant interactions between maternal PAH exposure and haplotype on cord B[a]P-DNA adducts in the following genes: maternal CYP1B1, XRCC1 and GSTM3, and newborn CYP1A2 and XRCC1 in African-Americans; and maternal XRCC1 and newborn NQO1 in Dominicans. Polycyclic Aromatic Hydrocarbons 51-54 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 174-180 24177223-8 2014 We found significant interactions between maternal PAH exposure and haplotype on cord B[a]P-DNA adducts in the following genes: maternal CYP1B1, XRCC1 and GSTM3, and newborn CYP1A2 and XRCC1 in African-Americans; and maternal XRCC1 and newborn NQO1 in Dominicans. Polycyclic Aromatic Hydrocarbons 51-54 X-ray repair cross complementing 1 Homo sapiens 185-190 24177223-8 2014 We found significant interactions between maternal PAH exposure and haplotype on cord B[a]P-DNA adducts in the following genes: maternal CYP1B1, XRCC1 and GSTM3, and newborn CYP1A2 and XRCC1 in African-Americans; and maternal XRCC1 and newborn NQO1 in Dominicans. Polycyclic Aromatic Hydrocarbons 51-54 X-ray repair cross complementing 1 Homo sapiens 185-190 24177223-8 2014 We found significant interactions between maternal PAH exposure and haplotype on cord B[a]P-DNA adducts in the following genes: maternal CYP1B1, XRCC1 and GSTM3, and newborn CYP1A2 and XRCC1 in African-Americans; and maternal XRCC1 and newborn NQO1 in Dominicans. Polycyclic Aromatic Hydrocarbons 51-54 NAD(P)H quinone dehydrogenase 1 Homo sapiens 244-248 24844894-2 2014 The total PAH concentrations (sum of the concentrations of 17 individual PAH compounds) in water samples ranged from 67 to 96 ng L(-1), which were predominated by two- and three-ring PAHs. Polycyclic Aromatic Hydrocarbons 183-187 phenylalanine hydroxylase Homo sapiens 10-13 25114913-8 2014 Lamin-A/C isoform 3, talin-1, and annexin A1 were identified as universal biomarkers for PAHs exposure. Polycyclic Aromatic Hydrocarbons 89-93 lamin A Danio rerio 0-19 24844894-8 2014 A selected number of concentration ratios of specific PAH compounds reflected a pattern of pyrogenic input as a major source of PAHs. Polycyclic Aromatic Hydrocarbons 128-132 phenylalanine hydroxylase Homo sapiens 54-57 23979979-1 2014 Myeloperoxidase (MPO) is a phase I enzyme playing a crucial role in metabolically activating a wide range of procarcinogens, such as polycyclic aromatic hydrocarbons and aromatic amines. Polycyclic Aromatic Hydrocarbons 133-165 myeloperoxidase Homo sapiens 0-15 25114913-8 2014 Lamin-A/C isoform 3, talin-1, and annexin A1 were identified as universal biomarkers for PAHs exposure. Polycyclic Aromatic Hydrocarbons 89-93 talin 1 Danio rerio 21-28 25114913-8 2014 Lamin-A/C isoform 3, talin-1, and annexin A1 were identified as universal biomarkers for PAHs exposure. Polycyclic Aromatic Hydrocarbons 89-93 annexin A1a Danio rerio 34-44 23979979-1 2014 Myeloperoxidase (MPO) is a phase I enzyme playing a crucial role in metabolically activating a wide range of procarcinogens, such as polycyclic aromatic hydrocarbons and aromatic amines. Polycyclic Aromatic Hydrocarbons 133-165 myeloperoxidase Homo sapiens 17-20 24077263-4 2013 PAHs are reactive towards a number of atmospheric oxidants, most notably the hydroxyl radical, ozone, the nitrate radical (NO3) and nitrogen dioxide. Polycyclic Aromatic Hydrocarbons 0-4 NBL1, DAN family BMP antagonist Homo sapiens 123-126 24025706-2 2013 Previously, we have observed that tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory cytokine, enhances genotoxicity of benzo[a]pyrene (B[a]P), a highly carcinogenic polycyclic aromatic hydrocarbon, in rat lung epithelial RLE-6TN cells, a model of alveolar type II cells. Polycyclic Aromatic Hydrocarbons 181-212 tumor necrosis factor Rattus norvegicus 34-61 23733406-1 2013 The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that belongs to the basic-helix-loop-helix (bHLH)-Per-ARNT-Sim (PAS) superfamily of transcription factors, mediates toxic response induced by environmental chemicals such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 251-283 aryl hydrocarbon receptor Homo sapiens 4-29 23733406-1 2013 The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that belongs to the basic-helix-loop-helix (bHLH)-Per-ARNT-Sim (PAS) superfamily of transcription factors, mediates toxic response induced by environmental chemicals such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 251-283 aryl hydrocarbon receptor Homo sapiens 31-34 23733406-1 2013 The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that belongs to the basic-helix-loop-helix (bHLH)-Per-ARNT-Sim (PAS) superfamily of transcription factors, mediates toxic response induced by environmental chemicals such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 285-288 aryl hydrocarbon receptor Homo sapiens 4-29 23733406-1 2013 The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that belongs to the basic-helix-loop-helix (bHLH)-Per-ARNT-Sim (PAS) superfamily of transcription factors, mediates toxic response induced by environmental chemicals such as polycyclic aromatic hydrocarbons (PAH). Polycyclic Aromatic Hydrocarbons 285-288 aryl hydrocarbon receptor Homo sapiens 31-34 24025706-2 2013 Previously, we have observed that tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory cytokine, enhances genotoxicity of benzo[a]pyrene (B[a]P), a highly carcinogenic polycyclic aromatic hydrocarbon, in rat lung epithelial RLE-6TN cells, a model of alveolar type II cells. Polycyclic Aromatic Hydrocarbons 181-212 tumor necrosis factor Rattus norvegicus 63-72 24025706-9 2013 Together, the present data suggests that the CYP1B1-catalyzed metabolism of polycyclic aromatic hydrocarbons might contribute to their enhanced bioactivation and genotoxic effects under inflammatory conditions. Polycyclic Aromatic Hydrocarbons 76-108 cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus 45-51 24105890-3 2013 We collected a compressor-generated DEP (C-DEP) and characterized it by conducting bioassay-directed fractionation of the extractable organics in Salmonella and correlating the results by hierarchical clustering with the concentrations of 32 polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 242-274 FERM, ARH/RhoGEF and pleckstrin domain protein 1 Homo sapiens 15-46 24105890-3 2013 We collected a compressor-generated DEP (C-DEP) and characterized it by conducting bioassay-directed fractionation of the extractable organics in Salmonella and correlating the results by hierarchical clustering with the concentrations of 32 polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 276-280 FERM, ARH/RhoGEF and pleckstrin domain protein 1 Homo sapiens 15-46 24140465-0 2013 Polycyclic aromatic hydrocarbons in food--efflux of the conjugated biomarker 1-hydroxypyrene is mediated by Breast Cancer Resistance Protein (ABCG2) in human intestinal Caco-2 cells. Polycyclic Aromatic Hydrocarbons 0-32 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 108-140 24127753-1 2013 The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates the toxicity of dioxins, polycyclic aromatic hydrocarbons and related environmental pollutants. Polycyclic Aromatic Hydrocarbons 118-150 aryl hydrocarbon receptor Homo sapiens 4-29 24127753-1 2013 The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates the toxicity of dioxins, polycyclic aromatic hydrocarbons and related environmental pollutants. Polycyclic Aromatic Hydrocarbons 118-150 aryl hydrocarbon receptor Homo sapiens 31-34 24140465-0 2013 Polycyclic aromatic hydrocarbons in food--efflux of the conjugated biomarker 1-hydroxypyrene is mediated by Breast Cancer Resistance Protein (ABCG2) in human intestinal Caco-2 cells. Polycyclic Aromatic Hydrocarbons 0-32 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 142-147 24260161-5 2013 RESULTS: We found positive interaction odds ratios (ORs) for both maternal and paternal smoking during pregnancy, EPHX1 H139R, and childhood brain tumors (P(interaction) = 0.02; 0.10), such that children with the high-risk (greater PAH activation) genotype were at a higher risk of brain tumors relative to children with the low-risk genotype when exposed to tobacco smoke during pregnancy. Polycyclic Aromatic Hydrocarbons 232-235 epoxide hydrolase 1 Homo sapiens 114-119 23993976-0 2013 Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cell migration by targeting MAPK phosphatase-5, regulating the activation of p38 MAPK. Polycyclic Aromatic Hydrocarbons 0-31 dual specificity phosphatase 10 Homo sapiens 135-153 23543013-0 2013 Global and MGMT promoter hypomethylation independently associated with genomic instability of lymphocytes in subjects exposed to high-dose polycyclic aromatic hydrocarbon. Polycyclic Aromatic Hydrocarbons 139-170 O-6-methylguanine-DNA methyltransferase Homo sapiens 11-15 23543013-8 2013 Among PAH-exposed workers, LINE-1 and MGMT methylation levels (with CpG site specificity) were significantly lowered. Polycyclic Aromatic Hydrocarbons 6-9 O-6-methylguanine-DNA methyltransferase Homo sapiens 38-42 23972908-3 2013 PAHs (Polycyclic Aromatic Hydrocarbons) levels in the range of 29.4-64.2 ng g(-1) (dry weight) indicated that PAH contamination level classified as low along the Aegean coast. Polycyclic Aromatic Hydrocarbons 6-38 phenylalanine hydroxylase Homo sapiens 0-3 21887816-5 2013 Comparison of genome-wide microarray expression profiles between a nonmutagenic and a mutagenic PAH-treated group revealed that xenobiotic response genes such as CYP1B1 were commonly upregulated in two groups and that DNA damage induced genes, especially p53-downstream genes such as p21 (CDKN1A) were upregulated only in the mutagenic PAH-treated group. Polycyclic Aromatic Hydrocarbons 96-99 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 162-168 21887816-5 2013 Comparison of genome-wide microarray expression profiles between a nonmutagenic and a mutagenic PAH-treated group revealed that xenobiotic response genes such as CYP1B1 were commonly upregulated in two groups and that DNA damage induced genes, especially p53-downstream genes such as p21 (CDKN1A) were upregulated only in the mutagenic PAH-treated group. Polycyclic Aromatic Hydrocarbons 96-99 tumor protein p53 Homo sapiens 255-258 21887816-5 2013 Comparison of genome-wide microarray expression profiles between a nonmutagenic and a mutagenic PAH-treated group revealed that xenobiotic response genes such as CYP1B1 were commonly upregulated in two groups and that DNA damage induced genes, especially p53-downstream genes such as p21 (CDKN1A) were upregulated only in the mutagenic PAH-treated group. Polycyclic Aromatic Hydrocarbons 96-99 cyclin dependent kinase inhibitor 1A Homo sapiens 284-287 21887816-5 2013 Comparison of genome-wide microarray expression profiles between a nonmutagenic and a mutagenic PAH-treated group revealed that xenobiotic response genes such as CYP1B1 were commonly upregulated in two groups and that DNA damage induced genes, especially p53-downstream genes such as p21 (CDKN1A) were upregulated only in the mutagenic PAH-treated group. Polycyclic Aromatic Hydrocarbons 96-99 cyclin dependent kinase inhibitor 1A Homo sapiens 289-295 21887816-5 2013 Comparison of genome-wide microarray expression profiles between a nonmutagenic and a mutagenic PAH-treated group revealed that xenobiotic response genes such as CYP1B1 were commonly upregulated in two groups and that DNA damage induced genes, especially p53-downstream genes such as p21 (CDKN1A) were upregulated only in the mutagenic PAH-treated group. Polycyclic Aromatic Hydrocarbons 336-339 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 162-168 21887816-7 2013 These data suggest that when PAHs enter the cells, lung epithelium induces PAH metabolic activating enzymes, and then the DNA damages-recognition signal is converged with p53 downstream genes. Polycyclic Aromatic Hydrocarbons 29-32 tumor protein p53 Homo sapiens 171-174 23993976-0 2013 Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cell migration by targeting MAPK phosphatase-5, regulating the activation of p38 MAPK. Polycyclic Aromatic Hydrocarbons 0-31 mitogen-activated protein kinase 14 Homo sapiens 184-187 23993976-0 2013 Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cell migration by targeting MAPK phosphatase-5, regulating the activation of p38 MAPK. Polycyclic Aromatic Hydrocarbons 33-36 dual specificity phosphatase 10 Homo sapiens 135-153 23993976-0 2013 Polycyclic aromatic hydrocarbon (PAH)-mediated upregulation of hepatic microRNA-181 family promotes cancer cell migration by targeting MAPK phosphatase-5, regulating the activation of p38 MAPK. Polycyclic Aromatic Hydrocarbons 33-36 mitogen-activated protein kinase 14 Homo sapiens 184-187 23993976-9 2013 Based on these results, we conclude that the miR-181 family plays a critical role in PAH-induced hepatocarcinogenesis by targeting MKP-5, resulting in the regulation of p38 MAPK activation. Polycyclic Aromatic Hydrocarbons 85-88 dual specificity phosphatase 10 Homo sapiens 131-136 23993976-9 2013 Based on these results, we conclude that the miR-181 family plays a critical role in PAH-induced hepatocarcinogenesis by targeting MKP-5, resulting in the regulation of p38 MAPK activation. Polycyclic Aromatic Hydrocarbons 85-88 mitogen-activated protein kinase 14 Homo sapiens 169-172 24084256-0 2013 Knockdown of AHR1A but not AHR1B exacerbates PAH and PCB-126 toxicity in zebrafish (Danio rerio) embryos. Polycyclic Aromatic Hydrocarbons 45-48 aryl hydrocarbon receptor 1a Danio rerio 13-18 23900036-0 2013 Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste. Polycyclic Aromatic Hydrocarbons 75-78 insulin like growth factor 1 Homo sapiens 10-15 23900036-0 2013 Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste. Polycyclic Aromatic Hydrocarbons 75-78 insulin like growth factor binding protein 3 Homo sapiens 20-27 23886934-1 2013 Cytochrome P450 (P450, CYP) 1 family plays a primary role in the detoxification and bioactivation of polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 101-133 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 0-29 23845848-0 2013 Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR. Polycyclic Aromatic Hydrocarbons 0-32 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 49-55 23845848-0 2013 Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR. Polycyclic Aromatic Hydrocarbons 0-32 nuclear receptor subfamily 1 group I member 2 Homo sapiens 78-81 23845848-1 2013 Metabolic activation of polycyclic aromatic hydrocarbons (PAH) is mediated mainly by cytochrome P450 monooxygenases (CYP) CYP1A1, 1A2 and 1B1. Polycyclic Aromatic Hydrocarbons 24-56 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 122-128 23845848-1 2013 Metabolic activation of polycyclic aromatic hydrocarbons (PAH) is mediated mainly by cytochrome P450 monooxygenases (CYP) CYP1A1, 1A2 and 1B1. Polycyclic Aromatic Hydrocarbons 58-61 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 122-128 23845848-2 2013 Several PAH are known to induce these CYP via aryl hydrocarbon receptor (AhR) signaling. Polycyclic Aromatic Hydrocarbons 8-11 aryl hydrocarbon receptor Homo sapiens 46-71 23845848-2 2013 Several PAH are known to induce these CYP via aryl hydrocarbon receptor (AhR) signaling. Polycyclic Aromatic Hydrocarbons 8-11 aryl hydrocarbon receptor Homo sapiens 73-76 23845848-3 2013 Recently, it was shown that the PAH benzo[a]pyrene (BaP) can induce CYP3A4 as well. Polycyclic Aromatic Hydrocarbons 32-35 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 68-74 23845848-5 2013 Metabolism by CYP3A4 is only known for dihydrodiol metabolites of PAH but not for their parent compounds. Polycyclic Aromatic Hydrocarbons 66-69 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 14-20 23845848-6 2013 In the present study, a CYP3A4 reporter gene assay, requiring the overexpression of PXR, was used to investigate whether the PAH parent compounds BaP, benzo[c]phenanthrene (BcP) and dibenzo[a,l]pyrene (DBalP) as well as their corresponding phase I metabolites, the respective dihydrodiols and diol epoxides, can induce CYP3A4 promoter activity. Polycyclic Aromatic Hydrocarbons 125-128 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 24-30 23845848-6 2013 In the present study, a CYP3A4 reporter gene assay, requiring the overexpression of PXR, was used to investigate whether the PAH parent compounds BaP, benzo[c]phenanthrene (BcP) and dibenzo[a,l]pyrene (DBalP) as well as their corresponding phase I metabolites, the respective dihydrodiols and diol epoxides, can induce CYP3A4 promoter activity. Polycyclic Aromatic Hydrocarbons 125-128 nuclear receptor subfamily 1 group I member 2 Homo sapiens 84-87 23845848-8 2013 Moreover, activation of PXR by all four compounds was detected by using a PXR transactivation assay, supporting that PXR mediates CYP3A4 induction by PAH. Polycyclic Aromatic Hydrocarbons 150-153 nuclear receptor subfamily 1 group I member 2 Homo sapiens 24-27 23845848-8 2013 Moreover, activation of PXR by all four compounds was detected by using a PXR transactivation assay, supporting that PXR mediates CYP3A4 induction by PAH. Polycyclic Aromatic Hydrocarbons 150-153 nuclear receptor subfamily 1 group I member 2 Homo sapiens 74-77 23845848-8 2013 Moreover, activation of PXR by all four compounds was detected by using a PXR transactivation assay, supporting that PXR mediates CYP3A4 induction by PAH. Polycyclic Aromatic Hydrocarbons 150-153 nuclear receptor subfamily 1 group I member 2 Homo sapiens 74-77 23845848-8 2013 Moreover, activation of PXR by all four compounds was detected by using a PXR transactivation assay, supporting that PXR mediates CYP3A4 induction by PAH. Polycyclic Aromatic Hydrocarbons 150-153 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 130-136 23845848-9 2013 Taken together, these results show that both PAH parent compounds as well as their phase I metabolites induce CYP3A4 promoter via the transcription factor PXR. Polycyclic Aromatic Hydrocarbons 45-48 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 110-116 23845848-9 2013 Taken together, these results show that both PAH parent compounds as well as their phase I metabolites induce CYP3A4 promoter via the transcription factor PXR. Polycyclic Aromatic Hydrocarbons 45-48 nuclear receptor subfamily 1 group I member 2 Homo sapiens 155-158 24084256-3 2013 The zebrafish (Danio rerio) has three identified AHRs: AHR1A and AHR1B, the roles of which are not yet well elucidated, and AHR2, which has been shown to mediate the toxicity of various anthropogenic compounds including dioxins, polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 267-299 aryl hydrocarbon receptor 2 Danio rerio 124-128 24084256-3 2013 The zebrafish (Danio rerio) has three identified AHRs: AHR1A and AHR1B, the roles of which are not yet well elucidated, and AHR2, which has been shown to mediate the toxicity of various anthropogenic compounds including dioxins, polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs). Polycyclic Aromatic Hydrocarbons 301-305 aryl hydrocarbon receptor 2 Danio rerio 124-128 24084256-4 2013 In this study, we sought to explore the role of the two AHR1 isoforms in PAH- and PCB-induced toxicity in zebrafish embryos utilizing morpholino gene knockdown of the AHR isoforms. Polycyclic Aromatic Hydrocarbons 73-76 aryl hydrocarbon receptor 1a Danio rerio 56-60 24084256-4 2013 In this study, we sought to explore the role of the two AHR1 isoforms in PAH- and PCB-induced toxicity in zebrafish embryos utilizing morpholino gene knockdown of the AHR isoforms. Polycyclic Aromatic Hydrocarbons 73-76 aryl hydrocarbon receptor 1a Danio rerio 56-59 24084256-5 2013 Knockdown of AHR1B did not affect the toxicity of PAH mixtures or PCB-126, whereas knockdown of AHR1A exacerbated the cardiac toxicity caused by PAH mixtures and PCB-126. Polycyclic Aromatic Hydrocarbons 145-148 aryl hydrocarbon receptor 1a Danio rerio 96-101 24084256-7 2013 As has been shown previously, knockdown of AHR2 resulted in protection from PAH- and PCB-induced cardiac deformities and prevented CYP1 enzyme activity in exposed embryos. Polycyclic Aromatic Hydrocarbons 76-79 aryl hydrocarbon receptor 2 Danio rerio 43-47 23846873-1 2013 The aryl hydrocarbon receptor (AHR)-dependent induction of cytochromes P450 (P450) such as CYP1A1 by 3-methylcholanthrene (MC) and related polycyclic aromatic hydrocarbons is well characterized. Polycyclic Aromatic Hydrocarbons 139-171 aryl-hydrocarbon receptor Mus musculus 4-29 23846873-1 2013 The aryl hydrocarbon receptor (AHR)-dependent induction of cytochromes P450 (P450) such as CYP1A1 by 3-methylcholanthrene (MC) and related polycyclic aromatic hydrocarbons is well characterized. Polycyclic Aromatic Hydrocarbons 139-171 aryl-hydrocarbon receptor Mus musculus 31-34 23846873-1 2013 The aryl hydrocarbon receptor (AHR)-dependent induction of cytochromes P450 (P450) such as CYP1A1 by 3-methylcholanthrene (MC) and related polycyclic aromatic hydrocarbons is well characterized. Polycyclic Aromatic Hydrocarbons 139-171 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 91-97 23972896-12 2013 CONCLUSIONS: Urinary PAH biomarkers were found to be positively associated with serum CRP and total WBC count independent of smoking and other potential confounders. Polycyclic Aromatic Hydrocarbons 21-24 C-reactive protein Homo sapiens 86-89 24143040-6 2013 RESULTS: The best available resolution of two bioactive isomers was achieved (r = 3.4) via using PAH (polycyclic aromatic hydrocarbons) polymeric C18 bonded phase column. Polycyclic Aromatic Hydrocarbons 97-100 Bardet-Biedl syndrome 9 Homo sapiens 146-149 23832801-3 2013 In the three sampled water sources, typical contaminant patterns were found, i.e., pesticides and polycyclic aromatic hydrocarbons (PAH) in surface water with concentrations of 0.020-3.5 mug/L and 0.004-0.12 mug/L, disinfection by-products in tap water with concentrations of 0.050-79 mug/L, and pharmaceuticals in wastewater treatment plant effluents with concentrations of 0.020-0.76 mug/L, respectively. Polycyclic Aromatic Hydrocarbons 98-130 nuclear RNA export factor 1 Homo sapiens 243-246 23832801-3 2013 In the three sampled water sources, typical contaminant patterns were found, i.e., pesticides and polycyclic aromatic hydrocarbons (PAH) in surface water with concentrations of 0.020-3.5 mug/L and 0.004-0.12 mug/L, disinfection by-products in tap water with concentrations of 0.050-79 mug/L, and pharmaceuticals in wastewater treatment plant effluents with concentrations of 0.020-0.76 mug/L, respectively. Polycyclic Aromatic Hydrocarbons 132-135 nuclear RNA export factor 1 Homo sapiens 243-246 24364327-9 2013 The ratios of Phe/Ant and Fla/Pyr demonstrated that the PAHs in the soil profiles could be primarily sourced from petroleum pollution. Polycyclic Aromatic Hydrocarbons 56-60 solute carrier family 25 member 6 Homo sapiens 18-21 23887904-2 2013 DEP contain a high level of polycyclic aromatic hydrocarbons, which activate the aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 28-60 aryl hydrocarbon receptor Rattus norvegicus 81-106 23887904-2 2013 DEP contain a high level of polycyclic aromatic hydrocarbons, which activate the aryl hydrocarbon receptor (AHR). Polycyclic Aromatic Hydrocarbons 28-60 aryl hydrocarbon receptor Rattus norvegicus 108-111 23810773-1 2013 BACKGROUND: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that recognizes a large number of xenobiotics, such as polycyclic aromatic hydrocarbons (PAHs), dioxins, and some endogenous ligands. Polycyclic Aromatic Hydrocarbons 146-178 aryl hydrocarbon receptor Homo sapiens 16-41 23810773-1 2013 BACKGROUND: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that recognizes a large number of xenobiotics, such as polycyclic aromatic hydrocarbons (PAHs), dioxins, and some endogenous ligands. Polycyclic Aromatic Hydrocarbons 146-178 aryl hydrocarbon receptor Homo sapiens 43-46 23810773-1 2013 BACKGROUND: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that recognizes a large number of xenobiotics, such as polycyclic aromatic hydrocarbons (PAHs), dioxins, and some endogenous ligands. Polycyclic Aromatic Hydrocarbons 180-184 aryl hydrocarbon receptor Homo sapiens 16-41 23810773-1 2013 BACKGROUND: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that recognizes a large number of xenobiotics, such as polycyclic aromatic hydrocarbons (PAHs), dioxins, and some endogenous ligands. Polycyclic Aromatic Hydrocarbons 180-184 aryl hydrocarbon receptor Homo sapiens 43-46 24143040-6 2013 RESULTS: The best available resolution of two bioactive isomers was achieved (r = 3.4) via using PAH (polycyclic aromatic hydrocarbons) polymeric C18 bonded phase column. Polycyclic Aromatic Hydrocarbons 102-134 Bardet-Biedl syndrome 9 Homo sapiens 146-149 24143040-8 2013 CONCLUSION: It is clear that the method was simple, rapid and reliable for the quantification of two compounds in new HPLC method within PAH polymeric C18. Polycyclic Aromatic Hydrocarbons 137-140 Bardet-Biedl syndrome 9 Homo sapiens 151-154 24073787-6 2013 RESULTS: After adjustment for potential confounders using linear regression, sperm PAH-DNA adducts were negatively associated with sperm concentration, total sperm count, sperm motility, and curvilinear velocity (VCL). Polycyclic Aromatic Hydrocarbons 83-86 vinculin Homo sapiens 213-216 24084344-0 2013 Cytogenetic damage in Turkish coke oven workers exposed to polycyclic aromatic hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms. Polycyclic Aromatic Hydrocarbons 59-91 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 110-116 24084344-0 2013 Cytogenetic damage in Turkish coke oven workers exposed to polycyclic aromatic hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms. Polycyclic Aromatic Hydrocarbons 59-91 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 118-124 23987121-0 2013 PAH-CALUX, an optimized bioassay for AhR-mediated hazard identification of polycyclic aromatic hydrocarbons (PAHs) as individual compounds and in complex mixtures. Polycyclic Aromatic Hydrocarbons 0-3 aryl hydrocarbon receptor Homo sapiens 37-40 24084344-0 2013 Cytogenetic damage in Turkish coke oven workers exposed to polycyclic aromatic hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms. Polycyclic Aromatic Hydrocarbons 59-91 epoxide hydrolase 1 Homo sapiens 126-131 24084344-0 2013 Cytogenetic damage in Turkish coke oven workers exposed to polycyclic aromatic hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms. Polycyclic Aromatic Hydrocarbons 59-91 glutathione S-transferase mu 1 Homo sapiens 133-138 23987121-0 2013 PAH-CALUX, an optimized bioassay for AhR-mediated hazard identification of polycyclic aromatic hydrocarbons (PAHs) as individual compounds and in complex mixtures. Polycyclic Aromatic Hydrocarbons 75-107 aryl hydrocarbon receptor Homo sapiens 37-40 24084344-0 2013 Cytogenetic damage in Turkish coke oven workers exposed to polycyclic aromatic hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms. Polycyclic Aromatic Hydrocarbons 59-91 glutathione S-transferase theta 1 Homo sapiens 140-145 23987121-0 2013 PAH-CALUX, an optimized bioassay for AhR-mediated hazard identification of polycyclic aromatic hydrocarbons (PAHs) as individual compounds and in complex mixtures. Polycyclic Aromatic Hydrocarbons 109-113 aryl hydrocarbon receptor Homo sapiens 37-40 23987121-5 2013 The PAH CALUX reporter cell line allows for specific, rapid (4 h exposure time) and reliable quantification of AhR-induced luciferase induction relative to benzo[a]pyrene (BaP), which is used as a positive reference PAH congener. Polycyclic Aromatic Hydrocarbons 4-7 aryl hydrocarbon receptor Homo sapiens 111-114 23987121-5 2013 The PAH CALUX reporter cell line allows for specific, rapid (4 h exposure time) and reliable quantification of AhR-induced luciferase induction relative to benzo[a]pyrene (BaP), which is used as a positive reference PAH congener. Polycyclic Aromatic Hydrocarbons 216-219 aryl hydrocarbon receptor Homo sapiens 111-114 24084344-0 2013 Cytogenetic damage in Turkish coke oven workers exposed to polycyclic aromatic hydrocarbons: Association with CYP1A1, CYP1B1, EPHX1, GSTM1, GSTT1, and GSTP1 gene polymorphisms. Polycyclic Aromatic Hydrocarbons 59-91 glutathione S-transferase pi 1 Homo sapiens 151-156 23877624-6 2013 The diagnostic ratios suggest that PM-bound PAH originate from municipal (PM1-2.5) and vehicular (PM1) combustion. Polycyclic Aromatic Hydrocarbons 44-47 transmembrane protein 11 Homo sapiens 74-77 23877624-6 2013 The diagnostic ratios suggest that PM-bound PAH originate from municipal (PM1-2.5) and vehicular (PM1) combustion. Polycyclic Aromatic Hydrocarbons 44-47 transmembrane protein 11 Homo sapiens 98-101 23756215-4 2013 C18-PSDs were an excellent biomimetic tool for PAHs with a low molecular weight in complex exposure conditions with different soil types, types of PAHs, aging periods, and initial PAH concentrations in soil. Polycyclic Aromatic Hydrocarbons 47-50 Bardet-Biedl syndrome 9 Homo sapiens 0-3 23865889-0 2013 Formation of nitro-PAHs from the heterogeneous reaction of ambient particle-bound PAHs with N2O5/NO3/NO2. Polycyclic Aromatic Hydrocarbons 19-23 NBL1, DAN family BMP antagonist Homo sapiens 97-100 23816456-4 2013 Therefore, we examined the role of haplotype based-CYP1A1 polymorphism in the effect of PAHs exposure on lung function in 422 participants from a community-based panel of elderly adults in Seoul, Korea. Polycyclic Aromatic Hydrocarbons 88-92 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 51-57 23838301-1 2013 A polymer monolith column was prepared using click chemistry for on-line solid phase microextraction of polycyclic aromatic hydrocarbons (PAHs), using 2,2",7,7"-tetraethynyl-9,9"-spirobifluorene(TES) and 1,4-bis(6-azidoalkoxy)benzene (BAB) as monomers, and Cu(PPh3)3Br as the catalyst. Polycyclic Aromatic Hydrocarbons 138-142 caveolin 1 Homo sapiens 260-264 23734862-5 2013 PEST descriptors were calculated from B3LYP/6-31G(d) optimized structures and found to have significant levels of correlation with k. PIP Min described the minimum local IP on the surface of the molecule and was found to be related to k. PEST technology appears to be an accurate method in predicting reactivity and could prove to be a valuable asset in building treatment models and in remediation design for PAHs and other organic contaminants in the environment. Polycyclic Aromatic Hydrocarbons 410-414 prolactin induced protein Homo sapiens 134-137 22415791-1 2013 Microsomal epoxide hydrolase (EPHX1) plays an important role in the activation and detoxification of polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 101-133 epoxide hydrolase 1 Homo sapiens 0-28 22415791-1 2013 Microsomal epoxide hydrolase (EPHX1) plays an important role in the activation and detoxification of polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke. Polycyclic Aromatic Hydrocarbons 101-133 epoxide hydrolase 1 Homo sapiens 30-35 23681797-1 2013 Microsomal epoxide hydrolase 1 (EPHX1) plays an important role in the detoxification of carcinogenic polycyclic aromatic hydrocarbons. Polycyclic Aromatic Hydrocarbons 101-133 epoxide hydrolase 1 Homo sapiens 32-37 23692869-1 2013 Our previous findings demonstrated that DNA damage by polynuclear aromatic hydrocarbons (PAHs) triggers a cellular protective response of growth inhibition (G1-S cell cycle arrest and inhibition of DNA synthesis) in human fibroblasts associated with accumulation of p53 protein, a growth-inhibitory transcription factor. Polycyclic Aromatic Hydrocarbons 54-87 tumor protein p53 Homo sapiens 266-269 23692869-1 2013 Our previous findings demonstrated that DNA damage by polynuclear aromatic hydrocarbons (PAHs) triggers a cellular protective response of growth inhibition (G1-S cell cycle arrest and inhibition of DNA synthesis) in human fibroblasts associated with accumulation of p53 protein, a growth-inhibitory transcription factor. Polycyclic Aromatic Hydrocarbons 89-93 tumor protein p53 Homo sapiens 266-269 23542445-2 2013 A significant part of these toxic effects is linked to the binding of some pollutants (like polycyclic aromatic hydrocarbons or PAHs) to the Aryl hydrocarbon Receptor (AhR) and the activation of target genes, like the cytochrome P4501A. Polycyclic Aromatic Hydrocarbons 92-124 aryl hydrocarbon receptor 1a Danio rerio 141-166 23542445-2 2013 A significant part of these toxic effects is linked to the binding of some pollutants (like polycyclic aromatic hydrocarbons or PAHs) to the Aryl hydrocarbon Receptor (AhR) and the activation of target genes, like the cytochrome P4501A. Polycyclic Aromatic Hydrocarbons 92-124 aryl hydrocarbon receptor 1a Danio rerio 168-171 23542445-2 2013 A significant part of these toxic effects is linked to the binding of some pollutants (like polycyclic aromatic hydrocarbons or PAHs) to the Aryl hydrocarbon Receptor (AhR) and the activation of target genes, like the cytochrome P4501A. Polycyclic Aromatic Hydrocarbons 128-132 aryl hydrocarbon receptor 1a Danio rerio 141-166 23542445-2 2013 A significant part of these toxic effects is linked to the binding of some pollutants (like polycyclic aromatic hydrocarbons or PAHs) to the Aryl hydrocarbon Receptor (AhR) and the activation of target genes, like the cytochrome P4501A. Polycyclic Aromatic Hydrocarbons 128-132 aryl hydrocarbon receptor 1a Danio rerio 168-171 22388733-1 2013 The AhR was initially identified as a ligand-activated transcription factor mediating effects of chlorinated dioxins and polycyclic aromatic hydrocarbons on cytochrome P450 1 (CYP1) expression. Polycyclic Aromatic Hydrocarbons 121-153 aryl hydrocarbon receptor Homo sapiens 4-7 22388733-1 2013 The AhR was initially identified as a ligand-activated transcription factor mediating effects of chlorinated dioxins and polycyclic aromatic hydrocarbons on cytochrome P450 1 (CYP1) expression. Polycyclic Aromatic Hydrocarbons 121-153 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 157-174 22388733-1 2013 The AhR was initially identified as a ligand-activated transcription factor mediating effects of chlorinated dioxins and polycyclic aromatic hydrocarbons on cytochrome P450 1 (CYP1) expression. Polycyclic Aromatic Hydrocarbons 121-153 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 176-180 23512538-1 2013 The aryl hydrocarbon receptor (AhR) is a ligand-mediated basic helix-loop-helix transcription factor of the Per/Arnt/Sim family that regulates adaptive and toxic responses to a variety of chemical pollutants, including polycyclic aromatic hydrocarbons and halogenated aromatic hydrocarbons, most notably 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polycyclic Aromatic Hydrocarbons 219-251 aryl hydrocarbon receptor Homo sapiens 4-29 23512538-1 2013 The aryl hydrocarbon receptor (AhR) is a ligand-mediated basic helix-loop-helix transcription factor of the Per/Arnt/Sim family that regulates adaptive and toxic responses to a variety of chemical pollutants, including polycyclic aromatic hydrocarbons and halogenated aromatic hydrocarbons, most notably 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polycyclic Aromatic Hydrocarbons 219-251 aryl hydrocarbon receptor Homo sapiens 31-34 23512538-1 2013 The aryl hydrocarbon receptor (AhR) is a ligand-mediated basic helix-loop-helix transcription factor of the Per/Arnt/Sim family that regulates adaptive and toxic responses to a variety of chemical pollutants, including polycyclic aromatic hydrocarbons and halogenated aromatic hydrocarbons, most notably 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Polycyclic Aromatic Hydrocarbons 219-251 aryl hydrocarbon receptor nuclear translocator Homo sapiens 112-116