PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2606106-0	1989	Primary structure of horse serotransferrin glycans.	Polysaccharides	43-50	serotransferrin	Equus caballus	27-42
2606106-3	1989	On the basis of the results concerning molecular mass determination and the carbohydrate analysis, it is concluded that the serotransferrin variant Tf 2a contains only one glycan while variants Tf 4b and Tf 5b contain two glycans.	Polysaccharides	172-178	serotransferrin	Equus caballus	124-139
2606106-3	1989	On the basis of the results concerning molecular mass determination and the carbohydrate analysis, it is concluded that the serotransferrin variant Tf 2a contains only one glycan while variants Tf 4b and Tf 5b contain two glycans.	Polysaccharides	222-229	serotransferrin	Equus caballus	124-139
2606106-5	1989	From the obtained results, it appears that the two glycans of Tf 5b variant are, like in human serotransferrin, of the N-acetyllactosaminic biantennary type, fully sialylated by two residues of N-acetylneuraminic acid (Neu5Ac; glycan type I).	Polysaccharides	51-58	transferrin	Homo sapiens	95-110
2606106-5	1989	From the obtained results, it appears that the two glycans of Tf 5b variant are, like in human serotransferrin, of the N-acetyllactosaminic biantennary type, fully sialylated by two residues of N-acetylneuraminic acid (Neu5Ac; glycan type I).	Polysaccharides	51-57	transferrin	Homo sapiens	95-110
2606106-7	1989	These results demonstrate that in an homozygous preparation of horse serotransferrin Tf 0, the heterogeneity is dependent, on the one hand, on the nature of the neuraminic acid substituting a N-acetyllactosaminic biantennary structure and, on the other hand, on the number of glycans bound to the polypeptide chain.	Polysaccharides	276-283	serotransferrin	Equus caballus	69-84
2606106-8	1989	Moreover, the differences which exist in the molecular mass of 77.5 kDA, 80 kDa and 82 kDa for serotransferrin variants Tf 2a, Tf 4b and Tf 5b, respectively, are not completely explained by the structure and the number of the glycans suggesting that the three variants should also differ in their polypeptide chain.	Polysaccharides	226-233	serotransferrin	Equus caballus	95-110
2531919-2	1989	Two similar genes, CD16-I and CD16-II, encode membrane glycoproteins that are anchored by phosphatidylinositol (PI)-glycan and transmembrane polypeptides, respectively.	Polysaccharides	116-122	Fc gamma receptor IIIa	Homo sapiens	19-23
2531919-2	1989	Two similar genes, CD16-I and CD16-II, encode membrane glycoproteins that are anchored by phosphatidylinositol (PI)-glycan and transmembrane polypeptides, respectively.	Polysaccharides	116-122	Fc gamma receptor IIIa	Homo sapiens	30-34
2531919-5	1989	Conversion of Phe to Ser in CD16-II permits expression of a PI-glycan-anchored glycoprotein, whereas conversion of Ser to Phe in CD16-I prevents PI-glycan linkage.	Polysaccharides	63-69	Fc gamma receptor IIIa	Homo sapiens	28-32
2684407-1	1989	A lipid, recently discovered as a contaminant of endotoxin and White-Type polysaccharide preparations from an unidentified isolate of Serratia marcescens, was named DCX for its direct cytotoxic activity.	Polysaccharides	74-88	doublecortin	Mus musculus	165-168
2513186-8	1989	As a characteristic feature, part of the triantennary glycans at Asn184 and Asn448 contain additional Gal(alpha 1-3) substituents and/or sulfate groups linked to position six of beta-galactosyl residues forming NeuAc(alpha 2-3)[HO3S-6]Gal(beta 1-4) units.	Polysaccharides	54-61	hemoglobin, beta adult major chain	Mus musculus	239-247
2619923-3	1989	The two fibronectin isoforms displayed distinct developmental differences in both glycosylation and binding properties: (i) Proportions of tri/tetraantennary complex glycans compared to the fraction of biantennary structures, as inferred from the reactivity with concanavalin A, were highest in amniotic fluid fibronectin from late pregnancy, lower in amniotic fluid fibronectin from early gestation, and even lower in fetal and adult plasma fibronectins.	Polysaccharides	166-173	fibronectin 1	Homo sapiens	8-19
2533389-0	1989	Interaction of tetranectin with sulphated polysaccharides and trypan blue.	Polysaccharides	42-57	C-type lectin domain family 3 member B	Homo sapiens	15-26
2627938-7	1989	First, as SP-A is a glycoprotein with N-glycosylated glycans it could act as a ligand for the mannose-specific receptor on macrophages.	Polysaccharides	53-60	surfactant protein A1	Homo sapiens	10-14
2616672-7	1989	The antitumor activity of the polysaccharide fractions was tested against the solid Sarcoma-180 in CD1 mice.	Polysaccharides	30-44	CD1 antigen complex	Mus musculus	99-102
2480118-4	1989	Binding of radioiodinated GMP-140 to heparin-Matrex-Pel 102 beads was divalent cation-independent and was strongly inhibited by excess fluid phase GMP-140 and heparin and by other sulfated glycans such as fucoidin and dextran-sulfate.	Polysaccharides	189-196	selectin P	Homo sapiens	26-33
2606651-0	1989	8-Mercaptoguanosine-mediated enhancement of in vivo IgG1, IgG2 and IgG3 antibody responses to polysaccharide antigens in normal and xid mice.	Polysaccharides	94-108	Immunoglobulin heavy constant gamma 3	Mus musculus	67-71
2478364-3	1989	This was characterized by the extent to which a polysaccharide could protect chemical modification of Lys-125 and Lys-136, two lysyl residues of antithrombin which have been implicated in heparin binding.	Polysaccharides	48-62	serpin family C member 1	Homo sapiens	145-157
2694696-0	1989	[Interleukin-1-inducing activity of the polysaccharide-containing antigens of the cell wall in Yersinia pestis].	Polysaccharides	40-54	interleukin 1 alpha	Homo sapiens	1-14
2574581-3	1989	The carbohydrate of gp120 recognized by lectins was thus arranged in at least four types of glycans: a high mannose type glycan, a bisected hybrid or complex type glycan, a biantennary fucosylated complex type glycan and a triantennary bisected complex type glycan.	Polysaccharides	92-99	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	20-25
2478195-3	1989	It was shown for the first time that the calcium-dependent polymerization of SAP was inhibited by some sulfated polysaccharides.	Polysaccharides	112-127	amyloid P component, serum	Homo sapiens	77-80
2610006-0	1989	The effect and distribution of a protein-bound polysaccharide preparation, PSK (Krestin), intratumorally injected prior to surgery into gastric cancer patients.	Polysaccharides	47-61	TAO kinase 2	Homo sapiens	75-78
2610006-2	1989	In the present study we have investigated the kinetics and the immune response augmenting effect of intratumorally injected PSK, a protein-bound polysaccharide preparation, by immunohistochemical methods using anti-PSK antibody and various other antibodies.	Polysaccharides	145-159	TAO kinase 2	Homo sapiens	124-127
2574581-3	1989	The carbohydrate of gp120 recognized by lectins was thus arranged in at least four types of glycans: a high mannose type glycan, a bisected hybrid or complex type glycan, a biantennary fucosylated complex type glycan and a triantennary bisected complex type glycan.	Polysaccharides	92-98	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	20-25
2574581-3	1989	The carbohydrate of gp120 recognized by lectins was thus arranged in at least four types of glycans: a high mannose type glycan, a bisected hybrid or complex type glycan, a biantennary fucosylated complex type glycan and a triantennary bisected complex type glycan.	Polysaccharides	121-127	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	20-25
2574581-3	1989	The carbohydrate of gp120 recognized by lectins was thus arranged in at least four types of glycans: a high mannose type glycan, a bisected hybrid or complex type glycan, a biantennary fucosylated complex type glycan and a triantennary bisected complex type glycan.	Polysaccharides	121-127	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	20-25
2574581-3	1989	The carbohydrate of gp120 recognized by lectins was thus arranged in at least four types of glycans: a high mannose type glycan, a bisected hybrid or complex type glycan, a biantennary fucosylated complex type glycan and a triantennary bisected complex type glycan.	Polysaccharides	121-127	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	20-25
2574581-4	1989	Only lectins which bound at least one of the four types of glycans were capable of inhibiting fusion of HIV-infected cells with CD4 cells by a carbohydrate-specific interaction with the HIV-infected cells.	Polysaccharides	59-66	CD4 molecule	Homo sapiens	128-131
2574581-5	1989	Thus, several different glycan structures may be implicated in CD4-gp120 binding.	Polysaccharides	24-30	CD4 molecule	Homo sapiens	63-66
2488771-4	1989	Each one of these Mabs recognized the polysaccharide region of LPS.	Polysaccharides	38-52	toll-like receptor 4	Mus musculus	63-66
2574581-5	1989	Thus, several different glycan structures may be implicated in CD4-gp120 binding.	Polysaccharides	24-30	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	67-72
2479114-3	1989	Sulfated polysaccharides potentiated generation of plasmin in mixtures of Glu-plg and scu-PA, as well as enhanced plasminogenolytic activity of u-PA.	Polysaccharides	9-24	plasminogen	Homo sapiens	51-58
2551687-0	1989	Presence of fucosylated triantennary, tetraantennary and pentaantennary glycans in transferrin synthesized by the human hepatocarcinoma cell line Hep G2.	Polysaccharides	72-79	transferrin	Homo sapiens	83-94
2551687-6	1989	These results indicate that the increase in the number of antennae in transferrin glycans synthesized by the hepatocarcinoma cell line is much more pronounced than in liver diseases such as alcoholic cirrhosis and that, in addition, the malignant transformation of human liver induces the presence of fucose.	Polysaccharides	82-89	transferrin	Homo sapiens	70-81
2479114-0	1989	Stimulation of plasmin catalyzed conversion of single-chain to two-chain urokinase-type plasminogen activator by sulfated polysaccharides.	Polysaccharides	122-137	plasminogen	Homo sapiens	15-22
2479114-3	1989	Sulfated polysaccharides potentiated generation of plasmin in mixtures of Glu-plg and scu-PA, as well as enhanced plasminogenolytic activity of u-PA.	Polysaccharides	9-24	plasminogen activator, urokinase	Homo sapiens	88-92
2479114-0	1989	Stimulation of plasmin catalyzed conversion of single-chain to two-chain urokinase-type plasminogen activator by sulfated polysaccharides.	Polysaccharides	122-137	plasminogen activator, urokinase	Homo sapiens	73-109
2481574-8	1989	Contrary to expectations, an increase of the total amount of biantennary glycans of rAGP, secreted during conditions associated with an increase in CAIE-3 was not found.	Polysaccharides	73-80	orosomucoid 1	Rattus norvegicus	84-88
2481574-10	1989	Consequently, not only the biantennary glycan content is responsible for the separation of rAGP in CAIE.	Polysaccharides	39-45	orosomucoid 1	Rattus norvegicus	91-95
2474610-9	1989	Absorption of the vaccinate IgA1 with alum-bound group C polysaccharide did not affect the killing of a sensitive strain, but it did potentiate the killing of a previously resistant strain.	Polysaccharides	57-71	immunoglobulin heavy constant alpha 1	Homo sapiens	28-32
16666984-8	1989	We suggest that some of the ChiA protein is N-glycosylated and secreted when expressed in plants, and that the modifications are complex glycans.	Polysaccharides	137-144	endochitinase A	Nicotiana tabacum	28-32
24201516-4	1989	The two glycans are typical small complex glycans with xylose, fucose, mannose and N-acetylglucosamine in a ratio 1:1:3:2, the same ratio as found on patatin isolated from potato tubers.	Polysaccharides	8-15	Patatin class I	Solanum tuberosum	150-157
24201516-4	1989	The two glycans are typical small complex glycans with xylose, fucose, mannose and N-acetylglucosamine in a ratio 1:1:3:2, the same ratio as found on patatin isolated from potato tubers.	Polysaccharides	42-49	Patatin class I	Solanum tuberosum	150-157
2818566-7	1989	It was found that only the higher-Mr polysaccharides (Mr greater than 8000) efficiently catalysed thrombin inhibition by heparin cofactor II, there being a progressive catalytic effect with increasing Mr of the polysaccharide.	Polysaccharides	37-52	coagulation factor II, thrombin	Homo sapiens	98-106
2818566-7	1989	It was found that only the higher-Mr polysaccharides (Mr greater than 8000) efficiently catalysed thrombin inhibition by heparin cofactor II, there being a progressive catalytic effect with increasing Mr of the polysaccharide.	Polysaccharides	37-51	coagulation factor II, thrombin	Homo sapiens	98-106
2818566-10	1989	In this situation, where the inhibitors competed for thrombin and for the (poly)saccharides, it was found that, provided the latter were of high affinity for antithrombin and exceeded a Mr of 5400, thrombin inhibition in plasma was mediated largely through antithrombin.	Polysaccharides	74-91	serpin family C member 1	Homo sapiens	158-170
2818566-10	1989	In this situation, where the inhibitors competed for thrombin and for the (poly)saccharides, it was found that, provided the latter were of high affinity for antithrombin and exceeded a Mr of 5400, thrombin inhibition in plasma was mediated largely through antithrombin.	Polysaccharides	74-91	coagulation factor II, thrombin	Homo sapiens	162-170
2818566-10	1989	In this situation, where the inhibitors competed for thrombin and for the (poly)saccharides, it was found that, provided the latter were of high affinity for antithrombin and exceeded a Mr of 5400, thrombin inhibition in plasma was mediated largely through antithrombin.	Polysaccharides	74-91	serpin family C member 1	Homo sapiens	257-269
2818566-11	1989	Polysaccharides of Mr exceeding 8000 that were of low affinity for antithrombin accelerated thrombin inhibition in plasma through their interaction with heparin cofactor II.	Polysaccharides	0-15	serpin family C member 1	Homo sapiens	67-79
2818566-11	1989	Polysaccharides of Mr exceeding 8000 that were of low affinity for antithrombin accelerated thrombin inhibition in plasma through their interaction with heparin cofactor II.	Polysaccharides	0-15	coagulation factor II, thrombin	Homo sapiens	71-79
2674947-6	1989	The glycans of granzyme A, but not those of cytolysin, are modified with phosphomannose moieties.	Polysaccharides	4-11	granzyme A	Rattus norvegicus	15-25
2545782-1	1989	Dextran sulfate, heparin, and certain other sulfated polysaccharides potently inhibit the adsorption of HIV to CD4+ cells.	Polysaccharides	53-68	CD4 antigen	Mus musculus	111-114
2545782-9	1989	Taken together, these data suggest that while both sulfated polysaccharides and anti-CD4 mAb inhibit gp120 binding, the sulfated polysaccharides interact with sites on CD4 that are distinct from those with which the antibodies bind.	Polysaccharides	129-144	CD4 antigen	Mus musculus	168-171
2545784-6	1989	That is, K/NK lymphocyte Fc gamma RIII was resistant to phosphatidylinositol-specific phospholipase C and surface expression of Fc gamma RIII was not affected on K/NK lymphocytes from patients with paroxysmal nocturnal hemoglobinuria, a disorder of hemopoietic stem cells resulting in deficient expression of glycan-phosphatidylinositol-anchored proteins.	Polysaccharides	309-315	Fc gamma receptor IIIa	Homo sapiens	25-38
2476115-16	1989	These results suggest that human factor Xa, at physiological concentrations, could activate human protein C in the presence of anionic phospholipids and that this activation could be potentiated by therapeutic concentrations of sulphated polysaccharides.	Polysaccharides	238-253	coagulation factor X	Homo sapiens	33-42
2571200-0	1989	Release of lipoprotein lipase and hepatic triglyceride lipase in rats by heparin and other sulphated polysaccharides.	Polysaccharides	101-116	lipoprotein lipase	Rattus norvegicus	11-29
2571200-1	1989	The ability of parenteral heparin to release the capillary-bound enzymes lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) into the circulation is shared by several other sulphated polysaccharides.	Polysaccharides	195-210	lipoprotein lipase	Rattus norvegicus	73-91
2757633-2	1989	When these cells were treated with a protein-bound polysaccharide, PSK, significantly higher amounts of differentiation-inducing activity were accumulated in the culture supernatant.	Polysaccharides	51-65	TAO kinase 2	Homo sapiens	67-70
2526734-9	1989	On the other hand, the small amounts of leukosialin expressed on the cell surface of monensin-treated cells carried the same glycans as those remaining blocked inside the cell.	Polysaccharides	125-132	LOC105369247	Homo sapiens	40-51
2500452-4	1989	The increase is prevented upon removal of ECM-bound bFGF by a neutral 2 M NaCl wash. Soluble heparin and heparan sulfate reduce the amount of ECM-bound bFGF released into the medium, possibly competing with ECM polysaccharides for heparinase-like enzymes produced by endothelial cells, suggesting that these enzymes are involved in the mobilization of ECM-bound bFGF.	Polysaccharides	211-226	fibroblast growth factor 2	Bos taurus	52-56
2500452-4	1989	The increase is prevented upon removal of ECM-bound bFGF by a neutral 2 M NaCl wash. Soluble heparin and heparan sulfate reduce the amount of ECM-bound bFGF released into the medium, possibly competing with ECM polysaccharides for heparinase-like enzymes produced by endothelial cells, suggesting that these enzymes are involved in the mobilization of ECM-bound bFGF.	Polysaccharides	211-226	fibroblast growth factor 2	Bos taurus	152-156
2500452-4	1989	The increase is prevented upon removal of ECM-bound bFGF by a neutral 2 M NaCl wash. Soluble heparin and heparan sulfate reduce the amount of ECM-bound bFGF released into the medium, possibly competing with ECM polysaccharides for heparinase-like enzymes produced by endothelial cells, suggesting that these enzymes are involved in the mobilization of ECM-bound bFGF.	Polysaccharides	211-226	fibroblast growth factor 2	Bos taurus	152-156
2525780-8	1989	These data demonstrate that both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms of the CD16 molecule exist and that they are differentially expressed on neutrophils and natural killer cells.	Polysaccharides	79-85	Fc gamma receptor IIIa	Homo sapiens	108-112
2776136-1	1989	The structures of the capsular polysaccharides from Klebsiella K41 and K12 are very similar and differ only in the lateral, terminal group of their respective repeating units.	Polysaccharides	31-46	keratin 12	Homo sapiens	71-74
2673508-2	1989	The computer program CASPER, used in the structural analysis of polysaccharides composed of repeating units, has been extended.	Polysaccharides	64-79	CASP8 and FADD like apoptosis regulator	Homo sapiens	21-27
2656652-1	1989	Escherichia coli lon mutants lack a major ATP-dependent protease, are sensitive to UV light and methylmethane sulfonate (MMS), and overproduce capsular polysaccharide.	Polysaccharides	152-166	putative ATP-dependent Lon protease	Escherichia coli	17-20
2618537-0	1989	[Effect of a protein-bound polysaccharide, PSK, on human hemopoietic progenitors].	Polysaccharides	27-41	TAO kinase 2	Homo sapiens	43-46
2722757-0	1989	Calcofluor- and lectin-binding exocellular polysaccharides of Azospirillum brasilense and Azospirillum lipoferum.	Polysaccharides	43-58	LOW QUALITY PROTEIN: lectin	Glycine max	16-22
2722757-10	1989	We conclude that azospirilla produce exocellular polysaccharides with calcofluor- and lectin-binding properties.	Polysaccharides	49-64	LOW QUALITY PROTEIN: lectin	Glycine max	86-92
2470746-0	1989	Interactions between human extracellular superoxide dismutase C and sulfated polysaccharides.	Polysaccharides	77-92	superoxide dismutase 3	Homo sapiens	27-61
2470746-2	1989	Addition of sulfated polysaccharides to EC-SOD C resulted in a prompt partial inhibition of the enzymic activity, in most cases amounting to 10-17%, but with the large dextran sulfate 500,000 amounting to 35%.	Polysaccharides	21-36	superoxide dismutase 3	Homo sapiens	40-46
2483535-0	1989	Time-dependent conformational change of thrombin molecules induced by sulfated polysaccharides.	Polysaccharides	79-94	coagulation factor II, thrombin	Homo sapiens	40-48
2483535-2	1989	It is probable that the strength of the interaction of thrombin depends mostly on the charge-density of strongly acidic sulfate groups in the polysaccharides.	Polysaccharides	142-157	coagulation factor II, thrombin	Homo sapiens	55-63
2483535-3	1989	The change in intrinsic fluorescence intensity of thrombin with time was closely correlated with the rate of inactivation of the enzyme in the presence of sulfated polysaccharides.	Polysaccharides	164-179	coagulation factor II, thrombin	Homo sapiens	50-58
2483535-6	1989	Therefore, extensive charge-neutralization of thrombin by the sulfated polysaccharides is able to induce time- and temperature-dependent intramolecular conformational change (irreversible denaturation) of the enzyme molecules.	Polysaccharides	71-86	coagulation factor II, thrombin	Homo sapiens	46-54
2467938-0	1989	Analysis of the mechanism of recognition in the complement alternative pathway using C3b-bound low molecular weight polysaccharides.	Polysaccharides	116-131	complement C3	Homo sapiens	85-88
2538547-6	1989	Endo F N-glycanase mixture, which acts on all glycan species, including triantennary chains, led to complete deglycosylation of gp120/160 and of CD4.	Polysaccharides	9-15	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	128-137
2777322-0	1989	Chromotropic character of bacterial acidic polysaccharides: Part II--Induction of metachromasy in cationic dye pinacyanol chloride by Klebsiella K10 capsular polysaccharide.	Polysaccharides	43-58	keratin 10	Homo sapiens	145-148
2777322-1	1989	The acidic capsular polysaccharide isolated from Klebsiella K10 exhibited chromotropic character with respect to induction of metachromasy in the cationic dye pinacyanol chloride (1-ethyl-2-[3-(1-ethyl-2(1H)-quinolylidene)propenyl]quinolinium chloride).	Polysaccharides	20-34	keratin 10	Homo sapiens	60-63
2467938-4	1989	In particulate form both polysaccharides are activators of C. The conjugates exhibited increased resistance to inactivation in the factor H-dependent assays compared to C3b not bound to CHO and to C3b bound to mono- or disaccharides.	Polysaccharides	25-40	complement factor H	Homo sapiens	131-139
2467938-4	1989	In particulate form both polysaccharides are activators of C. The conjugates exhibited increased resistance to inactivation in the factor H-dependent assays compared to C3b not bound to CHO and to C3b bound to mono- or disaccharides.	Polysaccharides	25-40	complement C3	Homo sapiens	197-200
2467938-7	1989	The results suggest that the recognition site which induces a reduction in the affinity of C3b for factor H is distinct from the thioester site of C3b and can recognize structural features of polysaccharides including size, sialic acid content, and possibly aspects of three-dimensional oligosaccharide structure.	Polysaccharides	192-207	complement C3	Homo sapiens	91-94
2467938-7	1989	The results suggest that the recognition site which induces a reduction in the affinity of C3b for factor H is distinct from the thioester site of C3b and can recognize structural features of polysaccharides including size, sialic acid content, and possibly aspects of three-dimensional oligosaccharide structure.	Polysaccharides	192-207	complement factor H	Homo sapiens	99-107
2467938-7	1989	The results suggest that the recognition site which induces a reduction in the affinity of C3b for factor H is distinct from the thioester site of C3b and can recognize structural features of polysaccharides including size, sialic acid content, and possibly aspects of three-dimensional oligosaccharide structure.	Polysaccharides	192-207	complement C3	Homo sapiens	147-150
2467939-2	1989	Covalent attachment of the complement (C) protein C3b to polysaccharides on biologic particles which activate the alternative pathway leads to changes in the affinity of C3b for factor H, a regulatory protein of the C system.	Polysaccharides	57-72	endogenous retrovirus group K member 3	Homo sapiens	50-53
2467939-2	1989	Covalent attachment of the complement (C) protein C3b to polysaccharides on biologic particles which activate the alternative pathway leads to changes in the affinity of C3b for factor H, a regulatory protein of the C system.	Polysaccharides	57-72	endogenous retrovirus group K member 3	Homo sapiens	170-173
2467939-2	1989	Covalent attachment of the complement (C) protein C3b to polysaccharides on biologic particles which activate the alternative pathway leads to changes in the affinity of C3b for factor H, a regulatory protein of the C system.	Polysaccharides	57-72	complement factor H	Homo sapiens	178-186
2467939-3	1989	In this study the size of the site with which the polysaccharides interact and its special relationship to the thioester site were investigated using a fluorimetric assay and soluble C3b attached to low m.w.	Polysaccharides	50-65	endogenous retrovirus group K member 3	Homo sapiens	183-186
2467939-7	1989	Beginning with tetrameric oligosaccharides a linear decrease in factor H binding was observed with increasing oligosaccharide size and the effect reached an apparent maximum with large polysaccharides.	Polysaccharides	185-200	complement factor H	Homo sapiens	64-72
2525100-2	1989	The CD16 antigen expressed on neutrophils is a 50 to 70-kDa glycoprotein attached to the plasma membrane by a phosphatidylinositol-glycan linkage that is susceptible to cleavage by phosphatidylinositol-specific phospholipase C (PIPLC).	Polysaccharides	131-137	Fc gamma receptor IIIa	Homo sapiens	4-8
2525100-2	1989	The CD16 antigen expressed on neutrophils is a 50 to 70-kDa glycoprotein attached to the plasma membrane by a phosphatidylinositol-glycan linkage that is susceptible to cleavage by phosphatidylinositol-specific phospholipase C (PIPLC).	Polysaccharides	131-137	phospholipase C beta 1	Homo sapiens	181-226
2525100-2	1989	The CD16 antigen expressed on neutrophils is a 50 to 70-kDa glycoprotein attached to the plasma membrane by a phosphatidylinositol-glycan linkage that is susceptible to cleavage by phosphatidylinositol-specific phospholipase C (PIPLC).	Polysaccharides	131-137	phospholipase C beta 1	Homo sapiens	228-233
2538547-6	1989	Endo F N-glycanase mixture, which acts on all glycan species, including triantennary chains, led to complete deglycosylation of gp120/160 and of CD4.	Polysaccharides	9-15	CD4 molecule	Homo sapiens	145-148
2538547-7	1989	Therefore, probably half of the glycan moieties of gp120/160 are composed of high mannose and biantennary chains, the other half being triantennary species.	Polysaccharides	32-38	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	51-60
2493268-4	1989	Variations in the glycan chain composition account for the differences in the Mr of PSP S2-5.	Polysaccharides	18-24	regenerating family member 1 alpha	Homo sapiens	84-87
2646636-6	1989	In light of previous findings on carboxyl-terminal requirements of PLAP these studies suggest that an essential signal for correct sorting between transmembrane insertion and phosphatidylinositol-glycan attachment resides in the cytoplasmic domain.	Polysaccharides	196-202	alkaline phosphatase, placental	Homo sapiens	67-71
2481389-0	1989	Hageman factor activation by polysaccharides: effect of molecular weight.	Polysaccharides	29-44	coagulation factor XII	Homo sapiens	0-14
2730347-2	1989	Commercial heparin has now been shown to be a mixture of over 100 different closely related sulfated polysaccharides of which only 10% activate antithrombin-III.	Polysaccharides	101-116	serpin family C member 1	Homo sapiens	144-160
2787614-1	1989	The immunopotentiating activity and mechanisms of PSAT and scleroglucan, two beta 1-3, beta 1-6 glucan, were investigated in mice: these polysaccharides increase the chemiluminescence of peritoneal phagocytes and the serum C3 level.	Polysaccharides	137-152	hemoglobin, beta adult major chain	Mus musculus	77-85
2787614-1	1989	The immunopotentiating activity and mechanisms of PSAT and scleroglucan, two beta 1-3, beta 1-6 glucan, were investigated in mice: these polysaccharides increase the chemiluminescence of peritoneal phagocytes and the serum C3 level.	Polysaccharides	137-152	hemoglobin, beta adult major chain	Mus musculus	87-95
2785852-0	1989	Synergistic induction of lymphokine (IL-2)-activated killer activity by IL-2 and the polysaccharide lentinan, and therapy of spontaneous pulmonary metastases.	Polysaccharides	85-99	interleukin 2	Mus musculus	37-41
2920013-0	1989	Physiological significance of the marked increased branching of the glycans of human serotransferrin during pregnancy.	Polysaccharides	68-75	transferrin	Homo sapiens	85-100
2920013-1	1989	Human serotransferrin (Tf) presents a microheterogeneity based on the existence of biantennary and triantennary glycans of the N-acetyl-lactosaminic type.	Polysaccharides	112-119	transferrin	Homo sapiens	6-21
2664120-6	1989	The type-specific polysaccharide of B-III-streptococci prepared by phenol-water extraction followed by gel-chromatography can be used as a screening antigen for the production of monoclonal antibodies against B-III-streptococci.	Polysaccharides	18-32	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	36-41
2651333-0	1989	Blocking of lymphocyte surface binding sites for the soluble suppressor factor by protein-bound polysaccharide, PSK.	Polysaccharides	96-110	peter pan homolog	Homo sapiens	53-78
2651333-1	1989	The ability of protein-bound polysaccharide (PSK) to block the suppressive activity of soluble suppressor factor (SSF) was investigated.	Polysaccharides	29-43	TAO kinase 2	Homo sapiens	45-48
2651333-1	1989	The ability of protein-bound polysaccharide (PSK) to block the suppressive activity of soluble suppressor factor (SSF) was investigated.	Polysaccharides	29-43	peter pan homolog	Homo sapiens	87-112
2651333-1	1989	The ability of protein-bound polysaccharide (PSK) to block the suppressive activity of soluble suppressor factor (SSF) was investigated.	Polysaccharides	29-43	peter pan homolog	Homo sapiens	114-117
2664120-6	1989	The type-specific polysaccharide of B-III-streptococci prepared by phenol-water extraction followed by gel-chromatography can be used as a screening antigen for the production of monoclonal antibodies against B-III-streptococci.	Polysaccharides	18-32	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	209-214
2586346-1	1989	Previously it was demonstrated that Klebsiella pneumoniae O3 lipopolysaccharide (KO3 LPS) exhibited much stronger adjuvant action on antibody response to subcutaneously (s.c.) injected sheep red blood cells or deaggregated bovine serum albumin than did other kinds of LPS, the R-form LPS lacking the O-specific polysaccharide chain of KO3 LPS (R-LPS), and the lipid A fractionated from KO3 LPS.	Polysaccharides	65-79	toll-like receptor 4	Mus musculus	344-349
2473270-1	1989	The ability of polysaccharide granules to activate the complement by covalently fixing C3b-factor and thus interact with the cells carrying C3b-receptors on the cytoplasmic membrane has been used to assess the neutrophil C3b-receptor function.	Polysaccharides	15-29	endogenous retrovirus group K member 3	Homo sapiens	87-90
2473270-1	1989	The ability of polysaccharide granules to activate the complement by covalently fixing C3b-factor and thus interact with the cells carrying C3b-receptors on the cytoplasmic membrane has been used to assess the neutrophil C3b-receptor function.	Polysaccharides	15-29	endogenous retrovirus group K member 3	Homo sapiens	140-143
2473270-1	1989	The ability of polysaccharide granules to activate the complement by covalently fixing C3b-factor and thus interact with the cells carrying C3b-receptors on the cytoplasmic membrane has been used to assess the neutrophil C3b-receptor function.	Polysaccharides	15-29	endogenous retrovirus group K member 3	Homo sapiens	140-143
2506553-0	1989	Comparison of drug binding capacities of three AAG glycan variants of human origin.	Polysaccharides	51-57	N-methylpurine DNA glycosylase	Homo sapiens	47-50
2741403-0	1989	[Absorption of C14-labeled dye "active red 5CX"++ immobilized on polysaccharides in the rat gastrointestinal tract].	Polysaccharides	65-80	anti-Mullerian hormone receptor type 2	Rattus norvegicus	15-18
2851976-5	1988	Our results indicate that insulin provokes co-ordinated increases in the net synthesis de novo of PI and its derivatives, PI phosphates and the PI-glycan, in BC3H-1 myocytes.	Polysaccharides	147-153	insulin	Homo sapiens	26-33
2976993-7	1988	The results of these functional experiments correlated well with the demonstration of direct binding of S protein to both polysaccharides but not to dermatan sulfate.	Polysaccharides	122-137	vitronectin	Homo sapiens	104-113
2463783-4	1988	On the contrary, human IgM was not bound by this column despite reports that it contains high-mannose type glycan chains.	Polysaccharides	107-113	immunoglobulin heavy constant mu	Mus musculus	23-26
3245840-0	1988	Analysis of the microheterogeneity of the glycan chain of rat transferrin.	Polysaccharides	42-48	transferrin	Rattus norvegicus	62-73
3245840-6	1988	The results indicated that rat transferrin may have 3 types of glycan chain: The major type (60%) corresponds to a molecular species with triantennary branching, while 30% consists of molecules with biantennary and 10% with tetraantennary branching.	Polysaccharides	63-69	transferrin	Rattus norvegicus	31-42
2903859-7	1988	Lyt- mutants were also able to produce type 3 and 6 capsular polysaccharides, and such strains showed the same degree of virulence in mice as did the isogenic Lyt+ parent.	Polysaccharides	61-76	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100	Mus musculus	0-3
2461712-1	1988	Pentosan polysulphate (PPS, SP 54, HEMOCLAR), a highly sulphated semi-synthetic polysaccharide of MW 4700 Daltons is as efficient as heparin in potentiating the mitogenic activity of acidic FGF (aFGF) on human umbilical vein endothelial cells (HUVEC).	Polysaccharides	80-94	fibroblast growth factor 1	Homo sapiens	183-193
3149515-2	1988	By associating permethylation--mass spectrometry and 1H NMR spectroscopy, the primary structure of the following transferrin glycans were determined: human, bovine, hen, horse, marsupial, mouse, rabbit, rat and sheep serotransferrins; human, mouse, bovine and goat lactotransferrins; hen and turkey ovotransferrins.	Polysaccharides	125-132	transferrin	Homo sapiens	113-124
3214155-12	1988	These data provide further evidence that sulfated polysaccharides such as mucin may be a source of sulfate for SRB in the human large gut.	Polysaccharides	50-65	LOC100508689	Homo sapiens	74-79
3149515-3	1988	The results obtained led to the conclusion that transferrin glycans are specific for each transferrin and, for a given transferrin, specific to the species.	Polysaccharides	60-67	transferrin	Homo sapiens	48-59
3149515-3	1988	The results obtained led to the conclusion that transferrin glycans are specific for each transferrin and, for a given transferrin, specific to the species.	Polysaccharides	60-67	transferrin	Homo sapiens	90-101
3149515-3	1988	The results obtained led to the conclusion that transferrin glycans are specific for each transferrin and, for a given transferrin, specific to the species.	Polysaccharides	60-67	transferrin	Homo sapiens	90-101
3169252-0	1988	Evidence for a single glycan moiety in rabbit serum transferrin and location of the glycan within the polypeptide chain.	Polysaccharides	22-28	transferrin	Homo sapiens	52-63
2905842-11	1988	Inhibition of thrombus formation by each sulfated polysaccharides was linearly related to the extent of thrombin inhibition achieved ex vivo.	Polysaccharides	50-65	prothrombin	Oryctolagus cuniculus	104-112
3233203-2	1988	Previous studies indicated that the negatively charged sulfate groups of the polysaccharide are critical for binding which suggested a binding mechanism involving basic residues of bindin.	Polysaccharides	77-91	bindin	Strongylocentrotus purpuratus	109-115
3169252-3	1988	From the amino acid sequence of the carbohydrate-containing cyanogen bromide fragment we have shown that the glycan is attached to an asparaginyl side chain at a position equivalent to residue 491 in the sequence of human serum transferrin.	Polysaccharides	109-115	transferrin	Homo sapiens	228-239
3204014-1	1988	A glycan extracted from Coriolus versicolor (PSK, Krestin) which has antitumor and immunomodulator properties produced marked morphological and biochemical changes when added to cultures of mouse peritoneal macrophages.	Polysaccharides	2-8	TAO kinase 2	Mus musculus	45-48
2971353-0	1988	Effects of an anti-tumor polysaccharide, schizophyllan, on interferon-gamma and interleukin 2 production by peripheral blood mononuclear cells.	Polysaccharides	25-39	interferon gamma	Homo sapiens	59-75
2971353-0	1988	Effects of an anti-tumor polysaccharide, schizophyllan, on interferon-gamma and interleukin 2 production by peripheral blood mononuclear cells.	Polysaccharides	25-39	interleukin 2	Homo sapiens	80-93
3137974-10	1988	On the other hand, a lower colipase affinity for isolipases A or C than for isolipase B or the C-terminal peptide could tentatively be attributed to a non-local (distant) disturbing effect of the negatively charged glycan chain, as sialic acid is present in both isoforms A and C. Finally, the present paper confirms and extends earlier studies on lipase-colipase interactions.	Polysaccharides	215-221	colipase	Sus scrofa	27-35
2457922-12	1988	The latter feature should result in a substantially different membrane anchorage mechanism of BGP I compared to CEA, which lacks the cytoplasmic domain and is anchored via a phosphatidylinositol-glycan structure.	Polysaccharides	195-201	CEA cell adhesion molecule 1	Homo sapiens	94-99
3211159-0	1988	Evidence that serum amyloid P component binds to mannose-terminated sequences of polysaccharides and glycoproteins.	Polysaccharides	81-96	amyloid P component, serum	Homo sapiens	14-39
3211159-2	1988	In the presence of calcium, SAP binds to certain complex polysaccharides, including agarose and zymosan.	Polysaccharides	57-72	amyloid P component, serum	Homo sapiens	28-31
3211159-10	1988	These findings indicate that mannose-terminated oligosaccharides of polysaccharides and glycoproteins represent a new class of ligands for SAP and suggest that SAP may function as a mannose-binding protein.	Polysaccharides	68-83	amyloid P component, serum	Homo sapiens	139-142
3211159-10	1988	These findings indicate that mannose-terminated oligosaccharides of polysaccharides and glycoproteins represent a new class of ligands for SAP and suggest that SAP may function as a mannose-binding protein.	Polysaccharides	68-83	amyloid P component, serum	Homo sapiens	160-163
2457922-12	1988	The latter feature should result in a substantially different membrane anchorage mechanism of BGP I compared to CEA, which lacks the cytoplasmic domain and is anchored via a phosphatidylinositol-glycan structure.	Polysaccharides	195-201	CEA cell adhesion molecule 3	Homo sapiens	112-115
2463843-0	1988	The inhibition of boar acrosin amidase activity by sulfated polysaccharides.	Polysaccharides	60-75	acrosin	Homo sapiens	23-30
2457021-2	1988	The effects of heparin and various related polysaccharides on the circular dichroic spectra of fibronectin and its 31-kDa NH2-terminal tryptic fragment were studied.	Polysaccharides	43-58	fibronectin 1	Homo sapiens	95-106
2463843-7	1988	We propose that the sulfated polysaccharide inhibition of acrosin amidase activity observed here is causally related to the previously observed sulfated polysaccharide inhibition of sperm binding to the zona pellucida.	Polysaccharides	29-43	acrosin	Homo sapiens	58-65
2463843-7	1988	We propose that the sulfated polysaccharide inhibition of acrosin amidase activity observed here is causally related to the previously observed sulfated polysaccharide inhibition of sperm binding to the zona pellucida.	Polysaccharides	153-167	acrosin	Homo sapiens	58-65
2456764-4	1988	This determinant being a distinctive feature of the glycan moiety of phosphatidyl-inositol anchored membrane proteins, it established the glycosyl-phosphatidyl-inositol nature of the GP-2 membrane anchor.	Polysaccharides	52-58	glycoprotein 2	Homo sapiens	183-187
3402460-4	1988	The occurrence of N-linked di-, tri- and tetraantennary glycans on these three molecular forms (AGP-A, -B, and -C) was studied by sequential lectin-affinity chromatography of the 14C-labelled glycopeptides.	Polysaccharides	56-63	orosomucoid 1	Homo sapiens	96-101
3402460-12	1988	It was shown that about 90% of the biantennary glycans of both AGP-B and AGP-C were disialylated while the remainder were monosialylated.	Polysaccharides	47-54	orosomucoid 2	Homo sapiens	63-68
3402460-15	1988	It is suggested that the decrease in the exposure of galactose residues from AGP-A to AGP-C is related to the concomittant decrease in branching of the glycans of the three molecular forms.	Polysaccharides	152-159	orosomucoid 1	Homo sapiens	77-82
3141330-0	1988	Antitumor effector mechanism at a distant site in the double grafted tumor system of PSK, a protein-bound polysaccharide preparation.	Polysaccharides	106-120	TAO kinase 2	Mus musculus	85-88
3369092-6	1988	Glycyrrhizin sulfate, dextran sulfate, PSK, which is a protein-bound polysaccharide extracted from Basidiomycetes, and human plasma containing anti-HIV antibody gave about 15-fold reduction in FI when compared to that of control.	Polysaccharides	69-83	TAO kinase 2	Homo sapiens	39-42
3183925-0	1988	Local induction of a tumor necrosis factor (TNF)-like cytotoxic factor in murine tissues with tumorous and nontumorous inflammation after systemic administration of antitumor polysaccharides.	Polysaccharides	175-190	tumor necrosis factor	Mus musculus	21-42
3183925-0	1988	Local induction of a tumor necrosis factor (TNF)-like cytotoxic factor in murine tissues with tumorous and nontumorous inflammation after systemic administration of antitumor polysaccharides.	Polysaccharides	175-190	tumor necrosis factor	Mus musculus	44-47
3234365-0	1988	Heterogeneity in copper and glycan content of ceruloplasmin in human serum differs in health and disease.	Polysaccharides	28-34	ceruloplasmin	Homo sapiens	46-59
3234365-4	1988	The glycan microheterogeneity of ceruloplasmin was analyzed by crossed affinoimmunoelectrophoresis with free Lens culinaris agglutinin (LCA) and wheat germ agglutinin (WGA).	Polysaccharides	4-10	ceruloplasmin	Homo sapiens	33-46
3169374-1	1988	The protein-bound polysaccharide preparation, PSK was tested for its ability to suppress carcinogenesis in spontaneous tumours in C3H/OuJ mice.	Polysaccharides	18-32	TAO kinase 2	Mus musculus	46-49
3387431-1	1988	The COOH-terminal amino acid of carcinoembryonic antigen (CEA) is shown to covalently link with ethanolamine, evidence consistent with the anchorage of CEA to the plasma membrane through a phosphatidylinositol-glycan tail.	Polysaccharides	210-216	CEA cell adhesion molecule 3	Homo sapiens	32-56
3387431-1	1988	The COOH-terminal amino acid of carcinoembryonic antigen (CEA) is shown to covalently link with ethanolamine, evidence consistent with the anchorage of CEA to the plasma membrane through a phosphatidylinositol-glycan tail.	Polysaccharides	210-216	CEA cell adhesion molecule 3	Homo sapiens	58-61
3387431-1	1988	The COOH-terminal amino acid of carcinoembryonic antigen (CEA) is shown to covalently link with ethanolamine, evidence consistent with the anchorage of CEA to the plasma membrane through a phosphatidylinositol-glycan tail.	Polysaccharides	210-216	CEA cell adhesion molecule 3	Homo sapiens	152-155
2836408-12	1988	The interaction is not essential to, but compatible with, the activation of protein C. Experiments involving treatment of thrombomodulin with various glycanases or with nitrous acid, followed by measurement of anticoagulant activities, indicated that the acidic domain is constituted by a sulfated galactosaminoglycan and not by a heparin-related polysaccharide as previously suggested.	Polysaccharides	347-361	thrombomodulin	Oryctolagus cuniculus	122-136
2965705-4	1988	N-Acetylglucosaminyltransferase I gave a 100-fold decrease in Vmax/Km for the avidin complex of Man5GlcNAc2-(biotinyl)Asn as compared to the free glycan derivative; the rate difference reflects a large (25x) decrease in the Vmax and a relatively small increase (4x) in Km.	Polysaccharides	146-152	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Rattus norvegicus	0-33
2967181-4	1988	P-HS 1 has a Mr of 175,000 and possesses four heparan sulfate side-chains (Mr 32,000) covalently bound to the protein core via a galactose- and xylose-containing polysaccharide-protein binding region.	Polysaccharides	162-176	prostaglandin-endoperoxide synthase 1	Bos taurus	0-6
3141579-0	1988	PSK, a polysaccharide from Coriolus vesicolor, enhances oxygen metabolism of murine peritoneal macrophages and the host resistance to listerial infection.	Polysaccharides	7-21	TAO kinase 2	Mus musculus	0-3
2833117-9	1988	It was concluded that lactoferrin in milk may function in the process of iron absorption through interaction with a small intestinal receptor and that fucosylated glycans on the carbohydrate chain of lactoferrin are necessary for receptor recognition.	Polysaccharides	163-170	lactotransferrin	Bos taurus	200-211
3141579-1	1988	PSK, a protein-bound polysaccharide isolated from the basidiomycete Coriolus vesicolor (Fr.)	Polysaccharides	21-35	TAO kinase 2	Mus musculus	0-3
16665943-3	1988	The sugar portion of HRGP(1) accounts for 94% of the molecule and contains galactose (66%) and arabinose (34%); these residues are present as polysaccharide side chains attached to hydroxyproline.	Polysaccharides	142-156	histidine rich glycoprotein	Homo sapiens	21-25
3358907-0	1988	Local induction of a cytotoxic factor in a murine tumour by systemic administration of an antitumour polysaccharide, MGA.	Polysaccharides	101-115	MAX gene associated	Mus musculus	117-120
3170055-0	1988	Fate and distribution of an antitumor protein-bound polysaccharide PSK (Krestin).	Polysaccharides	52-66	TAO kinase 2	Homo sapiens	67-70
3232916-0	1988	[Enhancement of resistance of mice Toxoplasma gondii by 2 polysaccharides beta 1-3, beta 1-6 (PSAT and Scleroglucan)].	Polysaccharides	58-73	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	74-82
2460403-5	1988	They show that the influence of the genetic background is predominant for the good response with at least four independent autosomal genes governing this response, including an Igh control as reported for other polysaccharides.	Polysaccharides	211-226	immunoglobulin heavy chain complex	Mus musculus	177-180
3139576-0	1988	Effect of PSK, a protein-bound polysaccharide from Coriolus versicolor, on drug-metabolizing enzymes in sarcoma-180 bearing and normal mice.	Polysaccharides	31-45	TAO kinase 2	Mus musculus	10-13
3436047-0	1987	Modification of transferrin by polysaccharides in cancer patients.	Polysaccharides	31-46	transferrin	Homo sapiens	16-27
3691797-0	1987	Binding of heparin or dermatan sulfate to thrombin is essential for the sulfated polysaccharide-accelerated inhibition of thrombin by heparin cofactor II.	Polysaccharides	81-95	coagulation factor II, thrombin	Homo sapiens	42-50
3691797-0	1987	Binding of heparin or dermatan sulfate to thrombin is essential for the sulfated polysaccharide-accelerated inhibition of thrombin by heparin cofactor II.	Polysaccharides	81-95	coagulation factor II, thrombin	Homo sapiens	122-130
3691797-0	1987	Binding of heparin or dermatan sulfate to thrombin is essential for the sulfated polysaccharide-accelerated inhibition of thrombin by heparin cofactor II.	Polysaccharides	81-95	serpin family D member 1	Homo sapiens	134-153
3372106-1	1988	Antiserum against a protein-bound polysaccharide preparation (PSK) was produced by immunizing New Zealand White rabbits with PSK.	Polysaccharides	34-48	TAO kinase 2	Mus musculus	62-65
3372106-1	1988	Antiserum against a protein-bound polysaccharide preparation (PSK) was produced by immunizing New Zealand White rabbits with PSK.	Polysaccharides	34-48	TAO kinase 2	Mus musculus	125-128
3691797-5	1987	These results indicate that the binding of heparin or dermatan sulfate to both thrombin and HC II is required for the sulfated polysaccharide-dependent acceleration of the thrombin inhibition by HC II, and the binding to thrombin is more essential for the reaction.	Polysaccharides	127-141	coagulation factor II, thrombin	Homo sapiens	79-87
3691797-5	1987	These results indicate that the binding of heparin or dermatan sulfate to both thrombin and HC II is required for the sulfated polysaccharide-dependent acceleration of the thrombin inhibition by HC II, and the binding to thrombin is more essential for the reaction.	Polysaccharides	127-141	serpin family D member 1	Homo sapiens	92-97
3691797-5	1987	These results indicate that the binding of heparin or dermatan sulfate to both thrombin and HC II is required for the sulfated polysaccharide-dependent acceleration of the thrombin inhibition by HC II, and the binding to thrombin is more essential for the reaction.	Polysaccharides	127-141	coagulation factor II, thrombin	Homo sapiens	172-180
3691797-5	1987	These results indicate that the binding of heparin or dermatan sulfate to both thrombin and HC II is required for the sulfated polysaccharide-dependent acceleration of the thrombin inhibition by HC II, and the binding to thrombin is more essential for the reaction.	Polysaccharides	127-141	serpin family D member 1	Homo sapiens	195-200
3691797-5	1987	These results indicate that the binding of heparin or dermatan sulfate to both thrombin and HC II is required for the sulfated polysaccharide-dependent acceleration of the thrombin inhibition by HC II, and the binding to thrombin is more essential for the reaction.	Polysaccharides	127-141	coagulation factor II, thrombin	Homo sapiens	172-180
2445511-3	1987	The system was used to determine the shift in immunoglobulin subclass patterns of specific antibodies against a variety of protein and polysaccharide antigens in individuals with a regulatory deficiency of a given IgG or IgA subclass.	Polysaccharides	135-149	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	221-224
3442627-7	1987	It is concluded that there exist two kinds of glycan microheterogeneity in rat transferrin and that they are unrelated to each other.	Polysaccharides	46-52	transferrin	Rattus norvegicus	79-90
3122730-8	1987	The serotransferrin glycan has the same primary structure but is only partially fucosylated (10-15%).	Polysaccharides	20-26	transferrin	Mus musculus	4-19
2447665-0	1987	Specificity of sulfated polysaccharides to accelerate the inhibition of activated protein C by protein C inhibitor.	Polysaccharides	24-39	serpin family A member 5	Homo sapiens	95-114
3430562-1	1987	PSK (Krestin) is a protein-bound polysaccharide isolated from cultured mycelia of Coriolus versicolor in basidiomycetes.	Polysaccharides	33-47	TAO kinase 2	Mus musculus	0-3
3497990-9	1987	Two doses of PRP-D in infants seven months of age and older induced antibody levels equal to or greater than levels in infants 24 months of age given the polysaccharide alone.	Polysaccharides	154-168	prion protein	Homo sapiens	13-16
2441848-5	1987	The glycan-dependent microheterogeneity of orosomucoid and ceruloplasmin was analyzed by crossed affinoimmunoelectrophoresis with lectins, and the patterns of the patients with benign inflammation and malignant disease were different.	Polysaccharides	4-10	ceruloplasmin	Homo sapiens	59-72
3624220-2	1987	A large portion of the polysaccharide chains of both preparations bound with high affinity to immobilized antithrombin.	Polysaccharides	23-37	serpin family C member 1	Homo sapiens	106-118
3624220-3	1987	Titrations monitored by tryptophan fluorescence showed that clam polysaccharide chains with Mr approximately 22,500 contained up to three binding sites for antithrombin and that the binding constants for the interaction of these chains with antithrombin were higher than those reported for mammalian heparin of comparable size.	Polysaccharides	65-79	serpin family C member 1	Homo sapiens	156-168
3624220-3	1987	Titrations monitored by tryptophan fluorescence showed that clam polysaccharide chains with Mr approximately 22,500 contained up to three binding sites for antithrombin and that the binding constants for the interaction of these chains with antithrombin were higher than those reported for mammalian heparin of comparable size.	Polysaccharides	65-79	serpin family C member 1	Homo sapiens	241-253
3624220-5	1987	The content of these saccharide sequences was found to increase with increasing affinity of the parent polysaccharide for antithrombin.	Polysaccharides	103-117	serpin family C member 1	Homo sapiens	122-134
3496381-3	1987	Both isolated regions of this LPS (PS and Lipid A) were able to induce IL 1 synthesis by monocytes and macrophages.	Polysaccharides	31-33	interleukin 1 complex	Mus musculus	71-75
3664521-1	1987	The capsular polysaccharide from Klebsiella Serotype K40 contains D-galactose, D-mannose, L-rhamnose, and D-glucuronic acid in the ratios of 4:1:1:1.	Polysaccharides	13-27	keratin 40	Homo sapiens	53-56
3664521-6	1987	Based on all of these results, the heptasaccharide structure 1 was assigned to the repeating unit of the K40 polysaccharide.	Polysaccharides	109-123	keratin 40	Homo sapiens	105-108
2443128-8	1987	On the addition of thrombin, a good Factor V activator, to the plasma before each sulphated polysaccharide, the inhibition of prothrombin activation was demonstrable only in the presence of higher concentrations of the sulphated polysaccharide.	Polysaccharides	92-106	coagulation factor II, thrombin	Homo sapiens	19-27
3499859-1	1987	The effect of PSK, a protein-bound polysaccharide with antitumor activity, on the host defence mechanism against tumor in sarcoma-180-bearing mice was examined.	Polysaccharides	35-49	TAO kinase 2	Mus musculus	14-17
3496381-5	1987	Macrophages from C3H/HeJ mice were unresponsive to Lipid A and to glycolipid M9, but produced IL 1 when incubated with PS or with a hydrophilic fragment isolated after methanolysis of the endotoxin.	Polysaccharides	119-121	interleukin 1 complex	Mus musculus	94-98
3606151-0	1987	[A suppressive effect of PSK, a protein-bound polysaccharide preparation, on tumor growth: a new effect of PSK on cell motility].	Polysaccharides	46-60	TAO kinase 2	Mus musculus	25-28
2440029-5	1987	Competition experiments using heparin, heparan sulfate, and other sulfated polysaccharides show that this fibronectin site interacts with heparin-like cell or particle surface components in promoting matrix-driven translocation.	Polysaccharides	75-90	fibronectin 1	Homo sapiens	106-117
2443128-8	1987	On the addition of thrombin, a good Factor V activator, to the plasma before each sulphated polysaccharide, the inhibition of prothrombin activation was demonstrable only in the presence of higher concentrations of the sulphated polysaccharide.	Polysaccharides	229-243	coagulation factor II, thrombin	Homo sapiens	19-27
3830182-0	1987	Structural investigation of Klebsiella serotype K10 capsular polysaccharide.	Polysaccharides	61-75	keratin 10	Homo sapiens	48-51
2951375-7	1987	Only a minor proportion of this polysaccharide bound with high affinity to antithrombin, and no 3-O-sulfated glucosamine residues were detected.	Polysaccharides	32-46	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	75-87
3830182-1	1987	The primary structure of Klebsiella serotype K10 capsular polysaccharide has been investigated using mainly the techniques of methylation, partial hydrolysis, and 1H and 13C NMR spectroscopy.	Polysaccharides	58-72	keratin 10	Homo sapiens	45-48
2881482-5	1987	Addition of soy polysaccharide had no effect on plasma insulin levels but appeared (p greater than 0.05) to lessen postprandial increases in glucagon and pancreatic polypeptide levels while it raised somatostatin levels.	Polysaccharides	16-30	somatostatin	Homo sapiens	200-212
3568000-0	1987	Studies of the primary structure of the capsular polysaccharide from Klebsiella serotype K15.	Polysaccharides	49-63	keratin 15	Homo sapiens	89-92
3568000-1	1987	The capsular polysaccharide of Klebsiella serotype K15 has been investigated mainly by methylation analysis, characterisation of the oligosaccharides obtained by partial acid hydrolysis, periodate oxidation, enzymic degradation, and 1H- and 13C-n.m.r.	Polysaccharides	13-27	keratin 15	Homo sapiens	51-54
2950092-3	1987	The glycan substrates had the general structure R-glycan where R represented either biotinyl-Asn-GlcNAc2- or 6-(biotinamido)hexanoyl-Asn-Glc-NAc2- and the protein used was avidin; the extension arm in one of the glycan substrates permitted the additional comparison of two avidin-biotin-glycan complexes.	Polysaccharides	4-10	NACC family member 2	Homo sapiens	100-104
2950092-3	1987	The glycan substrates had the general structure R-glycan where R represented either biotinyl-Asn-GlcNAc2- or 6-(biotinamido)hexanoyl-Asn-Glc-NAc2- and the protein used was avidin; the extension arm in one of the glycan substrates permitted the additional comparison of two avidin-biotin-glycan complexes.	Polysaccharides	50-56	NACC family member 2	Homo sapiens	100-104
2436811-10	1987	The other severe deficit in xid involves antibody formation to haptens on polysaccharide carriers.	Polysaccharides	74-88	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	28-31
3789756-1	1986	PSK is a protein-bound polysaccharide prepared from cultured mycelium of Coriolus versicolor.	Polysaccharides	23-37	TAO kinase 2	Mus musculus	0-3
2441925-4	1987	Polysaccharides are antithrombin-III and heparin co-factor-II dependent or independent regarding their biological activity.	Polysaccharides	0-15	serpin family C member 1	Homo sapiens	20-36
3815413-3	1986	Partial acid hydrolysis and phage depolymerization of K19 provided respectively a modified, linear form of the polysaccharide and oligosaccharides of the repeating unit, these were used for the structural elucidation of the original polymer.	Polysaccharides	111-125	keratin 19	Homo sapiens	54-57
3815413-5	1986	spectroscopy of the polysaccharide and derivatives permitted formulation of the following structure for K19: (formula; see text)	Polysaccharides	20-34	keratin 19	Homo sapiens	104-107
3494301-2	1987	When the polysaccharides were presented to the macrophages in a sterically fixed form, i.e. as microparticles, they induced the release of interleukin 1 (IL-1) from the macrophages.	Polysaccharides	9-24	interleukin 1 alpha	Homo sapiens	139-158
3813552-11	1987	These latter glycans, which were obtained as oligosaccharide alditols, had the following structure (with GalNAc free of sulfate or containing sulfate bound at either C-4 or C-6): delta 4,5GlcUA beta(1----3)GalNAc beta(1----4)GlcUA beta(1----3)Gal beta(1----3)Gal beta(1----4)Xyl-ol.	Polysaccharides	13-20	complement C4A (Rodgers blood group)	Homo sapiens	166-169
3803395-1	1987	The capsular polysaccharide of Klebsiella serotype K40 contained D-mannose, D-glucuronic acid, D-galactose, and L-rhamnose in the approximate molar ratios 1:1:1:2.	Polysaccharides	13-27	keratin 40	Homo sapiens	51-54
2438086-1	1987	Some sulfated polysaccharides, such as d-CGN, APS, and DSS, have carcinogenicity to the rat colorectum.	Polysaccharides	14-29	cingulin	Rattus norvegicus	41-44
3491858-1	1987	Fifty-three healthy infants received either Haemophilus influenzae type b capsular polysaccharide (PRP) mixed with diphtheria-pertussis-tetanus vaccine (DPT) or PRP conjugated covalently to diphtheria toxoid (PRP-D).	Polysaccharides	83-97	prion protein	Homo sapiens	99-102
3789757-1	1986	PSK is a protein-bound polysaccharide prepared from cultured mycelium of Coriolus versicolor.	Polysaccharides	23-37	TAO kinase 2	Mus musculus	0-3
3789758-1	1986	PSK is a protein-bound polysaccharide prepared from cultured mycelium of the Basidiomycete Coriolus versicolor.	Polysaccharides	23-37	TAO kinase 2	Mus musculus	0-3
2432674-3	1986	Since chymotrypsin has low affinity for heparin, the polysaccharide only doubled the inactivation of the enzyme by the AT III preparation.	Polysaccharides	53-67	serpin family C member 1	Bos taurus	119-125
3536966-0	1986	A monoclonal antibody against meningococcus group B polysaccharides distinguishes embryonic from adult N-CAM.	Polysaccharides	52-67	neural cell adhesion molecule 1	Homo sapiens	103-108
3536966-3	1986	Here we describe a monoclonal antibody raised against the capsular polysaccharides of meningococcus group B (Men B) which specifically distinguishes embryonic N-CAM from adult N-CAM.	Polysaccharides	67-82	neural cell adhesion molecule 1	Homo sapiens	159-164
3536966-3	1986	Here we describe a monoclonal antibody raised against the capsular polysaccharides of meningococcus group B (Men B) which specifically distinguishes embryonic N-CAM from adult N-CAM.	Polysaccharides	67-82	neural cell adhesion molecule 1	Homo sapiens	176-181
3782789-2	1986	Moreover, in both man and mice, IgG antibodies to polysaccharides are predominantly, but not exclusively, restricted to a single IgG subclass--IgG2 in man, and IgG3 in the mouse.	Polysaccharides	50-65	Immunoglobulin heavy constant gamma 3	Mus musculus	160-164
2948501-4	1986	The Apo E induced uptake of triglyceride emulsions by hepatocytes was inhibited by highly sulfated polysaccharides (i.e. heparin, dextran sulfate) but other glycosaminoglycans which did not bind the emulsion were ineffective in this inhibition.	Polysaccharides	99-114	apolipoprotein E	Homo sapiens	4-9
3095243-8	1986	Absorption of the SRC-2 globulin with C polysaccharide, however, failed to change its protective activity.	Polysaccharides	40-54	nuclear receptor coactivator 2	Mus musculus	18-23
2432675-1	1986	The effect of molecular weight and sulfate amount of sulfated polysaccharide on the thrombin inhibitory activity of heparin cofactor II was investigated by using various dextran sulfate fractions with different molecular weight and sulfur content.	Polysaccharides	62-76	coagulation factor II, thrombin	Homo sapiens	84-92
2430581-1	1986	Methyl glycoside of the tetrasaccharide GlcNAc(beta 1-2)Rha(alpha 1-2)Rha(alpha 1-3)Rha, which represents a repeating unit of the basic chain of Shigella flexneri O-antigenic polysaccharides, was synthesized using acylated monosaccharide synthons.	Polysaccharides	175-190	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	47-55
3632102-3	1986	Significant correlations were found between serum pre-albumin levels and the response to group A meningococcal polysaccharide vaccine and between serum albumin levels and the response to group C meningococcal polysaccharide vaccine.	Polysaccharides	111-125	albumin	Homo sapiens	54-61
2943808-10	1986	These studies indicate that immunization with PS elicits responses in two functionally distinct subgroups of Lyt-1-,2+, I-J+ T cells, and that these cells are distinguishable by their sensitivity to vinblastine sulfate.	Polysaccharides	46-48	CD5 antigen	Mus musculus	109-114
2430581-1	1986	Methyl glycoside of the tetrasaccharide GlcNAc(beta 1-2)Rha(alpha 1-2)Rha(alpha 1-3)Rha, which represents a repeating unit of the basic chain of Shigella flexneri O-antigenic polysaccharides, was synthesized using acylated monosaccharide synthons.	Polysaccharides	175-190	adrenoceptor alpha 1D	Homo sapiens	60-69
2430581-1	1986	Methyl glycoside of the tetrasaccharide GlcNAc(beta 1-2)Rha(alpha 1-2)Rha(alpha 1-3)Rha, which represents a repeating unit of the basic chain of Shigella flexneri O-antigenic polysaccharides, was synthesized using acylated monosaccharide synthons.	Polysaccharides	175-190	adrenoceptor alpha 1D	Homo sapiens	74-83
3083581-9	1986	Most, if not all, of the glycan units associated with the gp70 molecule are of the complex variety, as shown by their resistance to Endo-H cleavage.	Polysaccharides	25-31	embigin	Homo sapiens	58-62
3730415-9	1986	Mouse hepatic lipase eluted from heparin-Sepharose at lower salt concentration than rat or human hepatic lipase, demonstrating that it has a relatively low affinity for heparin-like polysaccharides.	Polysaccharides	182-197	lipase, hepatic	Mus musculus	6-20
3016729-10	1986	We propose that these activities as well as the negative charge and the higher buoyant density of the acidic, Mr 68,000 form of thrombomodulin are due to a heparin-like polysaccharide and, further, that this component can be separated from the major portion of the molecule, which contains the protein C activation site, through the action of a proteinase.	Polysaccharides	169-183	thrombomodulin	Oryctolagus cuniculus	128-142
3014853-5	1986	Complete recovery of nonstarch polysaccharides [NSP (dietary fiber)] was obtained.	Polysaccharides	31-46	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	48-51
3723139-1	1986	Marked tumor-regressing activity was induced in the serum of S180 tumor-bearing mice by injection of an antitumor polysaccharide, CM-TAK [carboxymethylated beta(1-3)glucan].	Polysaccharides	114-128	hemoglobin, beta adult major chain	Mus musculus	156-164
3086219-2	1986	We report here that the formerly observed interaction of CRP with snail galactans, as exemplified by Helix pomatia galactan, is not due to a lectin-like carbohydrate-binding reactivity, but, instead that CRP obviously binds to phosphate groups that are minor constituents of these polysaccharides.	Polysaccharides	281-296	C-reactive protein	Homo sapiens	57-60
2941141-2	1986	To evaluate the clinical effects of the anti-tumor polysaccharide Schizophyllan (SPG), a randomized study was done on 220 patients with Stage II or Stage III cervical cancer who had been given irradiation, concomitantly.	Polysaccharides	51-65	SPG16	Homo sapiens	81-84
3531087-0	1986	Immunopotentiative effect of polysaccharide from kefir grain, KGF-C, administered orally in mice.	Polysaccharides	29-43	fibroblast growth factor 7	Mus musculus	62-65
3531087-1	1986	Since a water-soluble polysaccharide (KGF-C) from the kefir grains was shown to have the property of retarding tumor growth in vivo when administered orally, the effect of KGF-C was examined on antibody responses to thymus-dependent antigen, sheep red blood cells (SRBC), and thymus-independent antigen, dinitrophenyl-Ficoll and trinitrophenyl-lipopolysaccharide.	Polysaccharides	22-36	fibroblast growth factor 7	Mus musculus	38-41
3712215-0	1986	Identification of a mouse serum protein increased by administration of an antitumor polysaccharide, PSK, as a variant of mouse transferrin and some of its biological activities.	Polysaccharides	84-98	TAO kinase 2	Mus musculus	100-103
3734842-1	1986	The antitumor polysaccharide CM-TAK [carboxymethylated beta(1-3)glucan] caused immediate and rapid loss of viable tumor cells from S180 solid tumors in ICR mice if it was given after a week of tumor growth.	Polysaccharides	14-28	hemoglobin, beta adult major chain	Mus musculus	55-63
3947671-2	1986	Therefore, alpha 1-acid glycoprotein was purified from normal (alpha 1-acid glycoproteine N) and phenobarbital-treated rats (alpha 1-acid glycoprotein PB) Glycans were separated by AX-10 chromatography and analysed by gas chromatography.	Polysaccharides	155-162	orosomucoid 1	Rattus norvegicus	11-36
3485094-4	1986	vWF binding is inhibited at high ionic strength or low pH, by some sulfated polysaccharides and by antibodies to vWF.	Polysaccharides	76-91	von Willebrand factor	Homo sapiens	0-3
2938549-2	1986	A protein-bound polysaccharide from Coliolus versicolor QUEL (Krestine, PSK) antagonistically elevated the activity of the enzyme.	Polysaccharides	16-30	TAO kinase 2	Homo sapiens	72-75
3712215-0	1986	Identification of a mouse serum protein increased by administration of an antitumor polysaccharide, PSK, as a variant of mouse transferrin and some of its biological activities.	Polysaccharides	84-98	transferrin	Mus musculus	127-138
3712215-1	1986	One of the so-called LC components, the content of which is increased in the serum of PSK (antitumor polysaccharide) treated mice, was purified by repeated ion-exchange column chromatography on DEAE-Sephadex A-50.	Polysaccharides	101-115	TAO kinase 2	Mus musculus	86-89
2436525-0	1986	Mechanisms for inhibition of the generation of thrombin activity by sulfated polysaccharides.	Polysaccharides	77-92	coagulation factor II, thrombin	Homo sapiens	47-55
3513235-1	1986	Intravenous administration of 60 mg/kg of a polysaccharide (MNR, MNZ, GLP/BO4, GLP/BO5) significantly decreases the mortality of mice exposed to a single dose of X rays.	Polysaccharides	44-58	euchromatic histone methyltransferase 1	Mus musculus	70-77
3513235-1	1986	Intravenous administration of 60 mg/kg of a polysaccharide (MNR, MNZ, GLP/BO4, GLP/BO5) significantly decreases the mortality of mice exposed to a single dose of X rays.	Polysaccharides	44-58	euchromatic histone methyltransferase 1	Mus musculus	79-86
2422780-5	1986	These findings indicate that free AT III is favorable for binding to the complexes of thrombin and highly sulfated polysaccharides having low affinities to AT III in the absence of NaC1.	Polysaccharides	115-130	serpin family C member 1	Bos taurus	34-40
2422780-5	1986	These findings indicate that free AT III is favorable for binding to the complexes of thrombin and highly sulfated polysaccharides having low affinities to AT III in the absence of NaC1.	Polysaccharides	115-130	serpin family C member 1	Bos taurus	156-162
3515994-4	1986	These findings indicate that chronic ethanol misuse exerts a more complex effect on the glycans of transferrin than previously realized.	Polysaccharides	88-95	transferrin	Homo sapiens	99-110
3510115-2	1986	Heparin is a complex polysaccharide, consisting of repeating dissacharide subunits, which exerts its anticoagulant effect by potentiating the inhibition of activated clotting proteins by the naturally occurring inhibitor antithrombin III.	Polysaccharides	21-35	serpin family C member 1	Homo sapiens	221-237
2940356-1	1986	Mouse ceruloplasmin, the level of which in serum increases on administration of antitumor polysaccharides, was shown to have enhancing effects on the antibody production of mouse spleen cells toward sheep red blood cells and restorative effects on the suppressed mixed lymphocyte reaction of spleen cells of tumor-bearing mice.	Polysaccharides	90-105	ceruloplasmin	Mus musculus	6-19
2430901-1	1986	A new bioactive factor capable of stimulating the production of acute-phase transport proteins, haptoglobin, hemopexin and ceruloplasmin, was found in mouse serum soon after the administration of lentinan, an immunomodulatory polysaccharide.	Polysaccharides	226-240	haptoglobin	Mus musculus	96-107
2430901-1	1986	A new bioactive factor capable of stimulating the production of acute-phase transport proteins, haptoglobin, hemopexin and ceruloplasmin, was found in mouse serum soon after the administration of lentinan, an immunomodulatory polysaccharide.	Polysaccharides	226-240	ceruloplasmin	Mus musculus	123-136
16664609-0	1986	Proteinase inhibitor I accumulation in tomato suspension cultures : induction by plant and fungal cell wall fragments and an extracellular polysaccharide secreted into the medium.	Polysaccharides	139-153	proteinase inhibitor I	Solanum lycopersicum	0-22
3715899-1	1986	A crude polysaccharide that hemolyzed human red blood cells of the ABO types was isolated from the condensed tannin fraction of Sorghum bicolor.	Polysaccharides	8-22	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	67-70
2422312-1	1985	A lectin with an affinity for certain sulphated polysaccharides, such as fucoidin and dextran sulphate, has been isolated from the vitelline membrane of hens" eggs and purified to homogeneity as assessed by two-dimensional gel electrophoresis.	Polysaccharides	48-63	galectin 3	Gallus gallus	2-8
2871659-2	1986	On the basis of an increase in G6PD and the GST-placental form, a sequence of altered cell populations ranging from simple ductular proliferation through dysplasia and cholangiofibroma to cholangiocellular carcinoma could be established, the latter three lesions being characterized by marked increase in polysaccharide production.	Polysaccharides	305-319	glucose-6-phosphate 1-dehydrogenase	Mesocricetus auratus	31-35
2871659-2	1986	On the basis of an increase in G6PD and the GST-placental form, a sequence of altered cell populations ranging from simple ductular proliferation through dysplasia and cholangiofibroma to cholangiocellular carcinoma could be established, the latter three lesions being characterized by marked increase in polysaccharide production.	Polysaccharides	305-319	glutathione S-transferase	Mesocricetus auratus	44-47
4092215-0	1985	Structural investigation of the capsular polysaccharide of Klebsiella serotype K35.	Polysaccharides	41-55	keratin 35	Homo sapiens	79-82
4092215-1	1985	The structure of the capsular polysaccharide (K antigen) of Klebsiella K35 has been established as having the pentasaccharide repeating unit shown ("four plus one" type).	Polysaccharides	30-44	keratin 35	Homo sapiens	71-74
2411283-4	1985	Standard heparin was the only sulphated polysaccharide that could equally inhibit thrombin generation and enhance the inactivation of factor Xa and thrombin by plasma.	Polysaccharides	40-54	coagulation factor X	Homo sapiens	134-143
3877057-7	1985	Initial glycosylation of transferrin was as rapid as that of alpha 1-antitrypsin, and essentially all of the transferrin in the rough endoplasmic reticulum contained glycans which bound to concanavalin A and were removed by endoglycosidase H. Only 3% of the transferrin isolated from the rough microsomes came from the plasma by endocytosis or adsorption.	Polysaccharides	166-173	transferrin	Rattus norvegicus	109-120
3877057-7	1985	Initial glycosylation of transferrin was as rapid as that of alpha 1-antitrypsin, and essentially all of the transferrin in the rough endoplasmic reticulum contained glycans which bound to concanavalin A and were removed by endoglycosidase H. Only 3% of the transferrin isolated from the rough microsomes came from the plasma by endocytosis or adsorption.	Polysaccharides	166-173	transferrin	Rattus norvegicus	109-120
4045195-0	1985	Properties of glycans that activate the human alternative complement pathway and interact with the human monocyte beta-glucan receptor.	Polysaccharides	14-21	C-type lectin domain containing 7A	Homo sapiens	114-134
3930489-3	1985	The polysaccharide produced in the presence of butyrate showed a lower charge density on anion exchange chromatography than did the control material and a 3-fold increased proportion (54 versus 17% for the control) of components with high affinity for antithrombin.	Polysaccharides	4-18	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	252-264
2411283-2	1985	The anticoagulant potency was measured by the ability of each sulphated polysaccharide to inhibit the generation of thrombin activity in plasma.	Polysaccharides	72-86	coagulation factor II, thrombin	Homo sapiens	116-124
2411283-3	1985	Similarly, the ability of the six sulphated polysaccharides to enhance the rates of inactivation either factor Xa or thrombin in defibrinated plasma containing calcium chloride and cephalin were also determined.	Polysaccharides	44-59	coagulation factor X	Homo sapiens	104-113
2411283-3	1985	Similarly, the ability of the six sulphated polysaccharides to enhance the rates of inactivation either factor Xa or thrombin in defibrinated plasma containing calcium chloride and cephalin were also determined.	Polysaccharides	44-59	coagulation factor II, thrombin	Homo sapiens	117-125
3875705-1	1985	We studied an immunogen consisting of oligosaccharides derived from Haemophilus influenzae type b capsular polysaccharide (PRP) coupled to CRM197, a nontoxic relative of diphtheria toxin.	Polysaccharides	107-121	prion protein	Homo sapiens	123-126
2411283-4	1985	Standard heparin was the only sulphated polysaccharide that could equally inhibit thrombin generation and enhance the inactivation of factor Xa and thrombin by plasma.	Polysaccharides	40-54	coagulation factor II, thrombin	Homo sapiens	148-156
2411283-7	1985	Our results therefore suggest that only sulphated polysaccharides that enhance the inactivation of thrombin by plasma and/or inhibit the generation of thrombin activity in plasma are good anticoagulants.	Polysaccharides	50-65	coagulation factor II, thrombin	Homo sapiens	99-107
2411283-7	1985	Our results therefore suggest that only sulphated polysaccharides that enhance the inactivation of thrombin by plasma and/or inhibit the generation of thrombin activity in plasma are good anticoagulants.	Polysaccharides	50-65	coagulation factor II, thrombin	Homo sapiens	151-159
3928681-7	1985	Concentration of CO2/HCO-3 in the physiologic range increased elaboration of polysaccharide into the medium and slowed the cell generation time from 2 to 6 h. Four other first-passage clinical isolates were all heavily encapsulated in DME with CO2/HCO-3, but variably encapsulated in DME without CO2/HCO-3.	Polysaccharides	77-91	complement C2	Homo sapiens	17-26
2411283-4	1985	Standard heparin was the only sulphated polysaccharide that could equally inhibit thrombin generation and enhance the inactivation of factor Xa and thrombin by plasma.	Polysaccharides	40-54	coagulation factor II, thrombin	Homo sapiens	82-90
4068376-1	1985	The antitumor activity of the polysaccharide fraction (OPS) obtained by the acid hydrolysis of Klebsiella O3 lipopolysaccharide (KO3 LPS) isolated from the culture supernatant of the decapsulated mutant strain LEN-1 (03: K1-) against both allogeneic tumor and syngeneic tumor systems in mice was compared with that of KO3 LPS.	Polysaccharides	30-44	eye lens protein 1	Mus musculus	210-215
2861857-0	1985	Binding of heparin fractions and other polysulfated polysaccharides to plasma fibronectin: effects of molecular size and degree of sulfation of polysaccharides.	Polysaccharides	52-67	fibronectin 1	Homo sapiens	78-89
2860973-5	1985	From these results we concluded that SSEA-1 determinant was carried by the large glycan.	Polysaccharides	81-87	fucosyltransferase 4	Mus musculus	37-43
3874882-1	1985	Haemophilus influenzae type b (Hib) capsular polysaccharide (PRP) was selectively hydrolyzed to reducing oligosaccharides, and the fraction containing 3-10 ribosylribitolphosphate repeating units (VS) was conjugated by reductive amination to diphtheria toxin (DTx), its nontoxic derivative CRM197 (Dcr), or diphtheria toxoid (DTd).	Polysaccharides	45-59	prion protein	Homo sapiens	61-64
3160257-4	1985	The procedure involved the synthesis of a polysaccharide from Glc-1-P and phosphorylase in the presence of the sample to be tested.	Polysaccharides	42-56	GLC1P	Homo sapiens	62-69
3979568-0	1985	Primary structure of two sialylated triantennary glycans from human serotransferrin.	Polysaccharides	49-56	transferrin	Homo sapiens	68-83
3980470-5	1985	Unlike the N-glycosidic glycans of human adult plasma fibronectin, which contain only traces of fucose and are completely sialylated, the glycans from amniotic fluid fibronectin are fucosylated and only partially sialylated.	Polysaccharides	24-31	fibronectin 1	Homo sapiens	54-65
3980470-5	1985	Unlike the N-glycosidic glycans of human adult plasma fibronectin, which contain only traces of fucose and are completely sialylated, the glycans from amniotic fluid fibronectin are fucosylated and only partially sialylated.	Polysaccharides	138-145	fibronectin 1	Homo sapiens	166-177
3980470-6	1985	The complex-type N-glycosidic glycans present in amniotic fluid fibronectin also include a fractional amount (0.1 mol) of glycans with a polylactosaminyl structure.	Polysaccharides	30-37	fibronectin 1	Homo sapiens	64-75
3980470-10	1985	These results show that amniotic fluid fibronectin differs from plasma fibronectin with regard to the number of glycans attached to the polypeptide and that the glycans present in these two fibronectins differ in structure.	Polysaccharides	112-119	fibronectin 1	Homo sapiens	39-50
2984286-2	1985	CR3 and K also bound to zymosan (Z), a yeast cell wall extract that contains primarily polysaccharide and no detectable protein.	Polysaccharides	87-101	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	0-3
2579976-2	1985	This soluble cell-free factor (ITF) is derived from splenic T cells from mice immunized with capsular polysaccharide (CP) of B. fragilis.	Polysaccharides	102-116	trefoil factor 3, intestinal	Mus musculus	31-34
3891963-1	1985	The biological and immunomodulating activities of polysaccharide fraction (GF-1), an antitumor poysaccharide fraction from cultured fruiting bodies of Grifola frondosa, was examined in mice.	Polysaccharides	50-64	gonadal fat pad weight 1	Mus musculus	75-79
4000132-7	1985	These results suggest that lipid A of LPS molecule is important in causing lethality and TNF release in vivo while the polysaccharide portion may be involved in delivering the lipid A moiety to TNF-producing cells.	Polysaccharides	119-133	tumor necrosis factor	Mus musculus	194-197
3856887-3	1985	Analysis with the periodic acid-Schiff reagent histochemical stain demonstrated that cab homozygotes also have reduced amounts of structural polysaccharides.	Polysaccharides	141-156	cardiac abnormality	Mus musculus	85-88
2859851-1	1985	The glycans of the Thy-1 antigen present on thymocytes and lymph-node T-lymphocytes were investigated after external labelling of the cells.	Polysaccharides	4-11	thymus cell antigen 1, theta	Mus musculus	19-32
2856927-4	1985	During chase, this band converted to a molecular ratio (Mr) = 25,000 polypeptide, probably derived from the latter by trimming of glucose or mannose residues from the three high-mannose glycan units of Thy-1.	Polysaccharides	186-192	thymus cell antigen 1, theta	Mus musculus	202-207
2578296-2	1985	Several materials were highly active in factor Xa inhibition and the reaction rate at constant factor Xa concentration appeared to be predicted by the extent of intrinsic antithrombin III fluorescence change induced by the polysaccharide.	Polysaccharides	223-237	serpin family C member 1	Homo sapiens	171-187
3919387-2	1985	This system, which is based on the autoimmune NZB mouse strain, has been used to produce a monoclonal IgG2a antibody against the meningococcus group B and Escherichia coli K1 polysaccharides, identical homopolymers of alpha (2----8)-linked units of N-acetylneuraminic acid that are extremely poor immunogens.	Polysaccharides	175-190	immunoglobulin heavy variable V1-9	Mus musculus	102-107
3935281-0	1985	[Role of glycans in the binding of human serotransferrin and lactotransferrin to human alveolar macrophages].	Polysaccharides	9-16	transferrin	Homo sapiens	41-56
4074512-1	1985	The research of antibodies for group A streptococcal polysaccharide (MSK) is affirming itself more and more for its value among serological researches of the streptococcal infection.	Polysaccharides	53-67	salt inducible kinase 1	Homo sapiens	69-72
3965047-5	1985	In addition, the ability of the three sulfated polysaccharides to simultaneously inhibit the generation of thrombin activity and to enhance the inactivation of the factor Xa added to initiate thrombin generation in plasma was determined.	Polysaccharides	47-62	prothrombin	Oryctolagus cuniculus	107-115
3935281-0	1985	[Role of glycans in the binding of human serotransferrin and lactotransferrin to human alveolar macrophages].	Polysaccharides	9-16	lactotransferrin	Homo sapiens	61-77
3936597-0	1985	[Primary structure of the glycan chains of normal C 1 esterase inhibitor (C 1-INH) after NMR analysis at 400 MHz].	Polysaccharides	26-32	serpin family G member 1	Homo sapiens	50-72
3936597-0	1985	[Primary structure of the glycan chains of normal C 1 esterase inhibitor (C 1-INH) after NMR analysis at 400 MHz].	Polysaccharides	26-32	serpin family G member 1	Homo sapiens	74-81
2860249-2	1985	Working on A+ rabbits, characterized by the presence on the brush-border hydrolases of glycans corresponding to the human blood group A-determinant structure, it was possible to separate the intracellular aminopeptidase into two major molecular forms with or without these determinants.	Polysaccharides	87-94	carboxypeptidase Q	Homo sapiens	205-219
2861158-0	1985	The role of serum in interleukin 1 production by human monocytes activated by endotoxins and their polysaccharide moieties.	Polysaccharides	99-113	interleukin 1 alpha	Homo sapiens	21-34
2861158-1	1985	Lipopolysaccharides (LPS) as well as polysaccharide (PS) moieties of Bordetella pertussis and Neisseria meningitidis endotoxins induced in vitro interleukin 1 (IL 1) secretion by human monocytes as evaluated by the co-mitogenic assay on C3H/HeJ thymocytes.	Polysaccharides	4-18	interleukin 1 alpha	Homo sapiens	145-158
2861158-1	1985	Lipopolysaccharides (LPS) as well as polysaccharide (PS) moieties of Bordetella pertussis and Neisseria meningitidis endotoxins induced in vitro interleukin 1 (IL 1) secretion by human monocytes as evaluated by the co-mitogenic assay on C3H/HeJ thymocytes.	Polysaccharides	22-24	interleukin 1 alpha	Homo sapiens	145-158
2861158-7	1985	The data presented suggest that the serum component(s) and the IL 1 inducers (LPS or PS) act in synergism by two different pathways since the two signals can be delivered sequentially.	Polysaccharides	79-81	interleukin 1 alpha	Homo sapiens	63-67
6442165-2	1984	Measurement of the affinity of its Fab" fragment for a series of galacto oligosaccharides--some of which carried deoxyfluoro groups--has made it possible to assign a binding mode of the polysaccharide that has the reducing end oriented from the heavy (H) chain toward the light (L) chain.	Polysaccharides	186-200	FA complementation group B	Homo sapiens	35-38
2999524-3	1985	In studies in Britain and Scandinavia where consumption of the chemical fraction of dietary fibre, the non-starch polysaccharides, has been determined using accurate methods, significant negative association between colon cancer occurrence and NSP consumption have been shown.	Polysaccharides	114-129	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	244-247
6433980-6	1984	Almost all of the glycopeptides in this population lost their ability to bind to lentil lectin upon fucosidase digestion, indicating that fetal plasma fibronectin possesses a substantial amount of fucosylated biantennary glycans.	Polysaccharides	221-228	fibronectin 1	Homo sapiens	151-162
6209209-0	1984	Adjuvant effect of bacterial LPS and/or alum precipitation in responses to polysaccharide and protein antigens.	Polysaccharides	75-89	toll-like receptor 4	Mus musculus	29-32
6090411-0	1984	lon transcriptional regulation of genes necessary for capsular polysaccharide synthesis in Escherichia coli K-12.	Polysaccharides	63-77	putative ATP-dependent Lon protease	Escherichia coli	0-3
6207810-10	1984	The catalysis was shown to be due to a weak electrostatic interaction, since it was completely reversed by concentrations of NaCl greater than 0.3 M. It is concluded that the mechanism is independent of the heparin high-affinity binding site on antithrombin III and is probably due to binding of the high-charge-density polysaccharide to the proteinase.	Polysaccharides	320-334	serpin family C member 1	Homo sapiens	245-261
6148073-9	1984	The major glycans linked to Asn-75 were of structures I and IIB, whereas all three "complex-type" chains were represented at Asn-99.	Polysaccharides	10-17	ATPase, class II, type 9B	Mus musculus	60-63
6093693-6	1984	The mucin fermenters isolated by enrichment had a very restricted ability to utilize complex polysaccharides and their constituent monosaccharides, suggesting that the presence of plant polysaccharides in the human colon is unlikely to prevent the use of colonic mucin as an energy source by bacteria.	Polysaccharides	93-108	LOC100508689	Homo sapiens	4-9
6093693-6	1984	The mucin fermenters isolated by enrichment had a very restricted ability to utilize complex polysaccharides and their constituent monosaccharides, suggesting that the presence of plant polysaccharides in the human colon is unlikely to prevent the use of colonic mucin as an energy source by bacteria.	Polysaccharides	186-201	LOC100508689	Homo sapiens	4-9
6441839-0	1984	Evaluation of PSK, an antitumor protein-bound polysaccharides, by thymocyte electrophoresis.	Polysaccharides	46-61	TAO kinase 2	Mus musculus	14-17
6477504-8	1984	In contrast, the much greater resemblance to human CRP confirms that the rat C-polysaccharide-binding/phosphocholine-binding protein is in fact rat CRP.	Polysaccharides	79-93	C-reactive protein	Homo sapiens	51-54
6477504-8	1984	In contrast, the much greater resemblance to human CRP confirms that the rat C-polysaccharide-binding/phosphocholine-binding protein is in fact rat CRP.	Polysaccharides	79-93	C-reactive protein	Rattus norvegicus	148-151
6377946-0	1984	Transferrin glycans: a possible link between alcoholism and hepatic siderosis.	Polysaccharides	12-19	transferrin	Rattus norvegicus	0-11
6429046-3	1984	Oxidized polysaccharide was covalently coupled by reductive amination to 1,4-diaminobutyl-derivatized bovine serum albumin.	Polysaccharides	9-23	albumin	Mus musculus	109-122
6491867-1	1984	Antitumor activity of a polysaccharide fraction (GF-1) extracted from cultured fruiting bodies of a fungus, Grifola frondosa, was examined on allogeneic and syngeneic tumors in mice.	Polysaccharides	24-38	gonadal fat pad weight 1	Mus musculus	49-53
6330537-0	1984	Interleukin 1 secretion by human monocytes stimulated by the isolated polysaccharide region of the Bordetella pertussis endotoxin.	Polysaccharides	70-84	interleukin 1 alpha	Homo sapiens	0-13
6330537-2	1984	This polysaccharide, previously found to be a very potent, macrophage-dependent, polyclonal B-cell activator and to mediate the specific binding of the endotoxin to macrophages, stimulated the interleukin 1 (IL 1) secretion by human monocytes; its potency was similar to that measured for the endotoxin.	Polysaccharides	5-19	interleukin 1 alpha	Homo sapiens	193-212
6330537-3	1984	It was concluded that endotoxin-induced IL 1 production may be initiated by the interaction of the polysaccharide chain of the B. pertussis endotoxin and a specific structure present on macrophages.	Polysaccharides	99-113	interleukin 1 alpha	Homo sapiens	40-44
6547193-5	1984	Both types of polysaccharides poly-(NAG-NAT) considered in this study favoured extended conformations, which in the case of 1,3 linked polymers showed less gain of length per saccharide unit compared to 1,4 linked poly-(NAG-NAT) residues.	Polysaccharides	14-29	N-acetyl-alpha-glucosaminidase	Homo sapiens	36-39
6584526-1	1984	Mouse peritoneal macrophages stimulated with insoluble glycans in vitro release high amounts of acid hydrolases, N-acetyl-beta-D-glucosaminidase, beta-D-glucuronidase, and beta-D-galactosidase.	Polysaccharides	55-62	O-GlcNAcase	Mus musculus	113-144
6584526-2	1984	The most potent of the stimulatory glycans is a beta-1,3-D-glucan isolated from yeast cell walls.	Polysaccharides	35-42	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	48-56
6584526-4	1984	Agarose, another insoluble glycan containing an alternating sequence of the disaccharide beta-1,3-D-galactose-alpha-1,4-3,6-anhydro-L-galactose units was less potent.	Polysaccharides	27-33	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	89-97
6709045-2	1984	Lysozyme, an enzyme which catalyses the hydrolysis of a beta-1----4 glycosidic linkage in polysaccharides, has been shown to be structurally related to alpha-LA and it has been proposed that they have arisen from a common ancestral gene.	Polysaccharides	90-105	lactalbumin, alpha	Rattus norvegicus	152-160
6547193-5	1984	Both types of polysaccharides poly-(NAG-NAT) considered in this study favoured extended conformations, which in the case of 1,3 linked polymers showed less gain of length per saccharide unit compared to 1,4 linked poly-(NAG-NAT) residues.	Polysaccharides	14-29	bromodomain containing 2	Homo sapiens	40-43
6547193-5	1984	Both types of polysaccharides poly-(NAG-NAT) considered in this study favoured extended conformations, which in the case of 1,3 linked polymers showed less gain of length per saccharide unit compared to 1,4 linked poly-(NAG-NAT) residues.	Polysaccharides	14-29	N-acetyl-alpha-glucosaminidase	Homo sapiens	220-223
6547193-5	1984	Both types of polysaccharides poly-(NAG-NAT) considered in this study favoured extended conformations, which in the case of 1,3 linked polymers showed less gain of length per saccharide unit compared to 1,4 linked poly-(NAG-NAT) residues.	Polysaccharides	14-29	bromodomain containing 2	Homo sapiens	224-227
6547193-6	1984	For a 1,3 linked sugar moiety of pseudomurein every pair of neighbouring peptides attached to glycan chain pointed in favoured conformations approximately to opposite sides of the strands, whereas in a 1,4 linked poly-(NAG-NAT) the peptides protruded approximately to the same side of the glycan moiety.	Polysaccharides	289-295	N-acetyl-alpha-glucosaminidase	Homo sapiens	219-222
6547193-9	1984	In poly-(1,3-NAG-NAT) the glycan chains possessed a zig-zag-like arrangement, whereas for glycan chains of the murein type relatively flat structures were preferred.	Polysaccharides	26-32	N-acetyl-alpha-glucosaminidase	Homo sapiens	13-16
6547193-9	1984	In poly-(1,3-NAG-NAT) the glycan chains possessed a zig-zag-like arrangement, whereas for glycan chains of the murein type relatively flat structures were preferred.	Polysaccharides	26-32	bromodomain containing 2	Homo sapiens	17-20
6472248-3	1984	We studied how the LMI factor of murine spleen cells changed with immunization of tumor cells, and intraperitoneal injection of protein polysaccharide (PSK) and/or cyclophosphamide (CPA).	Polysaccharides	136-150	TAO kinase 2	Mus musculus	152-155
6422543-0	1984	Genetic control of the murine IgM plaque-forming cell response to type III pneumococcal polysaccharide.	Polysaccharides	88-102	immunoglobulin heavy constant mu	Mus musculus	30-33
6607218-4	1984	Maximal C5a generation by HiTb as measured by neutrophil response in chemotaxis, shape change, and aggregation assays required specific antibody to the capsular polysaccharide, polyribosyl ribitol phosphate (PRP).	Polysaccharides	161-175	complement C5a receptor 1	Homo sapiens	8-11
24253332-1	1984	The regulation of starch synthesis and exocellular polysaccharide synthesis by GA3 was studied with cells of sweet potato grown as suspension in glycerol medium.	Polysaccharides	51-65	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	79-82
24253332-4	1984	On the other hand, the synthesis of exocellular polysaccharides composed of glucose, galactose, mannose and arabinose etc., was stimulated and a clear increase of the Man/Ara ratio was observed in the presence of GA3.	Polysaccharides	48-63	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	213-216
24253332-5	1984	These results may indicate that GA3 affects the regulation of starch synthesis and exocellular polysaccharide synthesis.	Polysaccharides	95-109	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	32-35
6608726-2	1984	After neuraminidase treatment, the O-linked carbohydrate is susceptible to digestion with an endoglycosidase (endo-beta-N-acetylgalactosaminidase) that cleaves glycans with the structure Gal(beta 1----3)-GalNAc-Ser/Thr, and sialic acid can be added back to this core oligosaccharide by specific sialyltransferases.	Polysaccharides	160-167	neuraminidase 1	Homo sapiens	6-19
6418214-5	1983	Experiments in vitro revealed the sulfated glycosaminoglycans chondroitin 4-sulfate and heparin, the polysaccharide dextran sulfate, and the trypanocidal drug suramin to be strongly inhibitory on the ganglioside GD1a neuraminidase activity of normal fibroblast homogenates.	Polysaccharides	101-115	neuraminidase 1	Homo sapiens	217-230
6701833-0	1984	Effect of plasma histidine-rich glycoprotein on the inhibition by anionic polysaccharides of thrombin-triggered platelet aggregation.	Polysaccharides	74-89	coagulation factor II, thrombin	Homo sapiens	93-101
6097326-6	1984	So could be explained the resistance towards proteases and the weak antigenicity of numerous glycoproteins as well as the peculiar behaviour and resistance of metastatic cancerous cells since it has been recently demonstrated that membrane glycoproteins and fibronectin of this kind of cells are significantly enriched in tri- and tetraantennary glycans.	Polysaccharides	346-353	fibronectin 1	Homo sapiens	258-269
6391658-1	1984	The effect of immunotherapy with a protein-bound polysaccharide preparation termed PSK on remission duration and survival of adults with acute nonlymphocytic leukemia (ANLL) was studied in a prospective randomized cooperative trial.	Polysaccharides	49-63	TAO kinase 2	Homo sapiens	83-86
6538436-5	1984	HEMPAS glycan was characterized by micelle formation, a monomer molecular weight of 4000, susceptibility to endo-beta-galactosidase and resistance to protease.	Polysaccharides	7-13	galactosidase beta 1	Homo sapiens	113-131
6440758-7	1984	The polysaccharide chains carry sulphate residues predominantly attached to C-4 of the galactosamine unit.	Polysaccharides	4-18	complement component 4B (Chido blood group)	Mus musculus	76-79
6689265-2	1983	It was found that only the Gc 1 protein (Gc1a isoform) was glycosylated, the glycan moiety representing about 1% of the protein.	Polysaccharides	77-83	olfactomedin 4	Homo sapiens	27-31
6642659-1	1983	The possibility that hepatobiliary transport of immunoglobulin A (IgA) immune complexes might eliminate bacterial antigens was investigated in mice with pneumococcal type III capsular polysaccharide and C carbohydrate and corresponding monoclonal antibodies.	Polysaccharides	184-198	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	48-64
6642659-1	1983	The possibility that hepatobiliary transport of immunoglobulin A (IgA) immune complexes might eliminate bacterial antigens was investigated in mice with pneumococcal type III capsular polysaccharide and C carbohydrate and corresponding monoclonal antibodies.	Polysaccharides	184-198	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	66-69
6642659-3	1983	Small doses (10 micrograms or less) of passively administered IgA antibody were sufficient to induce measurable transport of capsular polysaccharide into bile.	Polysaccharides	134-148	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	62-65
6229250-0	1983	Effect of alpha 1-proteinase inhibitor and sulphated polysaccharides on the activity of m beta-acrosin.	Polysaccharides	53-68	acrosin	Homo sapiens	95-102
6689265-3	1983	The structure of this O-glycosidically linked glycan was determined to be: Neu Ac alpha (2 leads to 3) Gal beta (1 leads to 3) GaINAc alpha (1 leads to 0) Ser (or Thr).	Polysaccharides	46-52	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	75-78
6414881-0	1983	Effect of thyrotropin-releasing hormone (TRH) on the synthesis and secretion of polysaccharides by the integument of gastropods.	Polysaccharides	80-95	thyrotropin releasing hormone	Homo sapiens	10-39
6630198-1	1983	The binding site of the chicken hepatic lectin involved in the clearance of N-acetylglucosamine-terminated serum glycoproteins was explored by a competitive binding assay using 3H-labeled agalacto-orosomucoid and various glycoproteins, polysaccharides, monosaccharides, and glycosides as inhibitors.	Polysaccharides	236-251	hepatic lectin	Gallus gallus	32-46
6414881-0	1983	Effect of thyrotropin-releasing hormone (TRH) on the synthesis and secretion of polysaccharides by the integument of gastropods.	Polysaccharides	80-95	thyrotropin releasing hormone	Homo sapiens	41-44
6414881-3	1983	It was found that physiological concentrations of TRH significantly inhibited the secretion of 35S-labeled sulfated polysaccharides by short-term in vitro incubated gastropod foot integument.	Polysaccharides	116-131	thyrotropin releasing hormone	Homo sapiens	50-53
6412493-3	1983	In the other case formalin-treated sheep red blood cells sensitized with group-specific polysaccharides obtained by alcohol precipitation from the cultural fluid of group A, C and Y meningococci with subsequent heating (designated as A-2, C-2, Y) were used.	Polysaccharides	88-103	ATPase H+ transporting V0 subunit a2	Homo sapiens	234-237
6615439-7	1983	The similar properties of antithrombin-thrombin complexes formed with or without heparin support the concept of a catalytic role for the polysaccharide in the antithrombin-thrombin reaction.	Polysaccharides	137-151	serpin family C member 1	Homo sapiens	26-38
6615439-7	1983	The similar properties of antithrombin-thrombin complexes formed with or without heparin support the concept of a catalytic role for the polysaccharide in the antithrombin-thrombin reaction.	Polysaccharides	137-151	coagulation factor II, thrombin	Homo sapiens	30-38
6615439-7	1983	The similar properties of antithrombin-thrombin complexes formed with or without heparin support the concept of a catalytic role for the polysaccharide in the antithrombin-thrombin reaction.	Polysaccharides	137-151	serpin family C member 1	Homo sapiens	159-171
6615439-7	1983	The similar properties of antithrombin-thrombin complexes formed with or without heparin support the concept of a catalytic role for the polysaccharide in the antithrombin-thrombin reaction.	Polysaccharides	137-151	coagulation factor II, thrombin	Homo sapiens	39-47
6190759-8	1983	IFN inducers (polyinosinic acid-polycytidylic acid, 6-MFA [a mixture of proteins, polysaccharides, and double-stranded DNA isolated from Aspergillus ochraceus ATCC 28706]) protected a significant number of mice against SFV infection.	Polysaccharides	82-97	interferon alpha 1	Homo sapiens	0-3
6409965-4	1983	Among the genes responsible for the antibody response to these polysaccharide antigens include those coded for by genes located on the X chromosome and those on chromosome 17 linked to genes in the H-2 and/or Qa loci.	Polysaccharides	63-77	histocompatibility-2, MHC	Mus musculus	198-201
6409965-5	1983	The use of B10 congenic mice revealed that two genes on chromosome 17 are involved in the regulation of the antibody response to bacterial polysaccharide antigens.	Polysaccharides	139-153	granzyme C	Mus musculus	11-14
24264541-7	1983	In all instances, hemagglutinating activity was inhibited by galactose, anti-soybean agglutinin (SBA), and lectin-binding polysaccharide produced by Rhizobium japonicum.	Polysaccharides	122-136	LOW QUALITY PROTEIN: lectin	Glycine max	107-113
6225467-6	1983	Analysis of the scission products on Bio-Gel P-10 yielded fragments varying in size from single disaccharides to glycans consisting of nine disaccharide units.	Polysaccharides	113-120	S100 calcium binding protein A10	Homo sapiens	45-49
6852092-6	1983	Polysaccharide antibodies were mostly in the IgG3 fraction (36-62%) and in the IgG1 fraction (18-36%).	Polysaccharides	0-14	Immunoglobulin heavy constant gamma 3	Mus musculus	45-49
6852092-6	1983	Polysaccharide antibodies were mostly in the IgG3 fraction (36-62%) and in the IgG1 fraction (18-36%).	Polysaccharides	0-14	LOC105243590	Mus musculus	79-83
6187368-3	1983	Both beta-galactosidase and serum albumin were stabilized by conjugation with polysaccharide.	Polysaccharides	78-92	galactosidase beta 1	Bos taurus	5-23
6189553-16	1983	In vitro degradation implying cleavage of sialic acid residues, but probably also proteolysis and/or cleavage of different glycans converted the neonatal form of BSP-2 into the triplet pattern and ultimately into a p120 component.	Polysaccharides	123-130	integrin binding sialoprotein	Mus musculus	162-167
6833951-2	1983	After intravenous injection of the edema-producing PS, vascular permeability increase (measured by 125I-human serum albumin) was detected in the limbs, but not in the heart, lungs, spleen, liver, thymus, kidney, skin, skeletal muscle, submandibular lymph nodes, mesenteric lymph nodes, or ascending colon.	Polysaccharides	51-53	albumin	Rattus norvegicus	110-123
6409088-0	1983	A new isotype sequence (V kappa 27) of the variable region of kappa-light chains from a mouse hybridoma-derived anti-(streptococcal group A polysaccharide) antibody containing an additional cysteine residue.	Polysaccharides	140-154	immunoglobulin kappa variable 4-74	Mus musculus	24-31
6409088-2	1983	The first complete sequence of the variable region of a kappa-light chain (V kappa) from a mouse anti-(streptococcal group A polysaccharide) antibody (immunoglobulin 7S34.1) is reported.	Polysaccharides	125-139	immunoglobulin kappa variable 4-74	Mus musculus	56-82
6187368-3	1983	Both beta-galactosidase and serum albumin were stabilized by conjugation with polysaccharide.	Polysaccharides	78-92	albumin	Bos taurus	28-41
6405810-0	1983	Structural studies of glycans isolated from rat plasma hemopexin.	Polysaccharides	22-29	hemopexin	Rattus norvegicus	55-64
6185616-5	1983	Data, which support the conclusion from these experiments that Lyb-5+ cells are required for an anti-polysaccharide response even when the immunizing antigen is thymus-dependent, include the failure of IM6-KLH to stimulate a normal anti-Dex response in mice with the xid defect and the direct demonstration in normal adult mice that elimination of Lyb-5+ cells from spleens of mice primed with IM6-KLH abolishes the ability of these cells to transfer an anti-Dex response.	Polysaccharides	101-115	B-lymphocyte antigen 5	Mus musculus	63-68
6683306-0	1983	Augmentation of host"s immunity by combined cryodestruction of sarcoma 180 and administration of protein-bound polysaccharide, EA6, isolated from Flammulina velutipes (Curt.	Polysaccharides	111-125	erythrocyte antigen 6	Mus musculus	127-130
6683306-4	1983	Augmentation of the host"s immunity by combined in situ freeze-destruction of the tumor (cryosurgery) and administration of the antitumor active protein-bound polysaccharide, EA6, isolated from a hot water extract of an edible mushroom, Flammulina velutipes (Curt.	Polysaccharides	159-173	erythrocyte antigen 6	Mus musculus	175-178
6189236-6	1983	On the contrary, pentosane polysulfate, a sulfated polysaccharide (of low molecular weight) significantly increased the binding of fibrinogen (p less than 0.01).	Polysaccharides	51-65	fibrinogen beta chain	Homo sapiens	131-141
6220984-0	1983	The effect of PS-K, a protein bound polysaccharide, on immune responses against allogeneic antigens.	Polysaccharides	36-50	TAO kinase 2	Mus musculus	14-18
16662771-7	1983	beta-Galactosidase II was the only enzyme capable of hydrolyzing a polysaccharide that was isolated from tomatoes and that consisted primarily of beta-1, 4-linked galactose.	Polysaccharides	67-81	beta-galactosidase, chloroplastic	Solanum lycopersicum	0-18
6867480-0	1983	Effect of a protein-bound polysaccharide PS-K on the complement system.	Polysaccharides	26-40	TAO kinase 2	Homo sapiens	41-45
6867480-1	1983	A protein-bound polysaccharide from mycelia of Coriolus versicolor PS-K, clinically used as an immunomodulator, has been shown to restore the decreased cellular immune response and to exhibit host-mediated antitumor activity.	Polysaccharides	16-30	TAO kinase 2	Homo sapiens	67-71
7150660-0	1982	Human fibrinogen gel formed by the action of a cell surface polysaccharide obtained from a Staphylococcus.	Polysaccharides	60-74	fibrinogen beta chain	Homo sapiens	6-16
7150660-1	1982	An alkali-stable polysaccharide (called compact-colony forming active substance; substance 1) obtained from the cell surface of a strain of Staphylococcus epidermidis caused gel formation of human fibrinogen, with no release of fibrinopeptides.	Polysaccharides	17-31	fibrinogen beta chain	Homo sapiens	197-207
6132465-5	1982	The inhibition of thrombin activity by these polysaccharides was studied in purified systems with or without added Antithrombin III, using both fibrinogen clotting and chromogenic peptide substrate assays.	Polysaccharides	45-60	coagulation factor II, thrombin	Homo sapiens	18-26
6185616-6	1983	The data imply that the expressed B cell repertoire in adult animals is skewed such that the vast majority of B cells capable of responding to polysaccharide determinants are in the Lyb-5+ subset.	Polysaccharides	143-157	B-lymphocyte antigen 5	Mus musculus	182-187
6891904-5	1982	Thus, anticarcinogenic action was revealed in LAP or LAP1 fractions which were mainly composed of xylose-containing polysaccharide and protein.	Polysaccharides	116-130	leucine aminopeptidase 3	Rattus norvegicus	46-49
6891904-5	1982	Thus, anticarcinogenic action was revealed in LAP or LAP1 fractions which were mainly composed of xylose-containing polysaccharide and protein.	Polysaccharides	116-130	alanyl aminopeptidase, membrane	Rattus norvegicus	53-57
6174521-3	1982	Two N-glycosidic glycans are present in each alpha-fetoprotein molecule.	Polysaccharides	17-24	alpha fetoprotein	Homo sapiens	45-62
7131453-3	1982	Fibronectin levels were related to the development of serum turbidity in the cold and fibronectin was involved in the development of cold turbidity induced by some charged polysaccharides in plasma, serum, and SF.	Polysaccharides	172-187	fibronectin 1	Homo sapiens	86-97
7116205-1	1982	Human transferrin consists of a single chain polypeptide which supports two N-glycosidically linked glycans at sequons a and b. Glycopeptides were released from human transferrin by proteolytic digestion, desialylated by mild acid hydrolysis, and then isolated by chromatographic methods.	Polysaccharides	100-107	transferrin	Homo sapiens	6-17
7116205-1	1982	Human transferrin consists of a single chain polypeptide which supports two N-glycosidically linked glycans at sequons a and b. Glycopeptides were released from human transferrin by proteolytic digestion, desialylated by mild acid hydrolysis, and then isolated by chromatographic methods.	Polysaccharides	100-107	transferrin	Homo sapiens	167-178
7116205-11	1982	The glycan structures and their locations on the polypeptide are related to the known subpopulations of human transferrin.	Polysaccharides	4-10	transferrin	Homo sapiens	110-121
28305378-6	1982	Precipitation tests demonstrated that besides vitellogenin, another major yolk protein, chromoprotein 2, reacts with sulfated polysaccharides.	Polysaccharides	126-141	putative uncharacterized protein LOC400499	Homo sapiens	46-58
7092889-0	1982	Glycan uniformity within molecular variants of transferrin with distinct affinity for concanavalin A.	Polysaccharides	0-6	transferrin	Homo sapiens	47-58
6816218-4	1982	One glycan unit is presented in rabbit serum transferrin and it is located in the C-terminal domain.	Polysaccharides	4-10	transferrin	Homo sapiens	45-56
6811862-1	1982	A murine BALB/c IgG2a (lambda 3) myeloma immunoglobulin SAPC-15 with binding activity for negatively charged polysaccharides has been purified by affinity chromatography, and its interaction with heparin and various other polyanionic antigens has been studied.	Polysaccharides	109-124	immunoglobulin heavy variable V1-9	Mus musculus	16-21
6802821-5	1982	This change is correlated with a loss of terminal alpha 1 leads to 3-mannosyl residues, an effect on the mnn1 lesion that is found also in the polysaccharide outer chain and hydroxyamino acid-linked mannooligosaccharides.	Polysaccharides	143-157	alpha-1,3-mannosyltransferase MNN1	Saccharomyces cerevisiae S288C	105-109
6174521-6	1982	The results indicate that 75% of alpha-fetoprotein molecules contain two triantennary complex-type glycans, 20% contain one triantennary and one biantennary glycan, and 5% contain two biantennary glycans.	Polysaccharides	99-106	alpha fetoprotein	Homo sapiens	33-50
6174521-6	1982	The results indicate that 75% of alpha-fetoprotein molecules contain two triantennary complex-type glycans, 20% contain one triantennary and one biantennary glycan, and 5% contain two biantennary glycans.	Polysaccharides	99-105	alpha fetoprotein	Homo sapiens	33-50
6174521-6	1982	The results indicate that 75% of alpha-fetoprotein molecules contain two triantennary complex-type glycans, 20% contain one triantennary and one biantennary glycan, and 5% contain two biantennary glycans.	Polysaccharides	196-203	alpha fetoprotein	Homo sapiens	33-50
6462134-6	1981	Heparin at a molar concentration well below that of plasmin still accelerates the reaction: one molecule of the polysaccharide is able to facilitate the inactivation of about 100 molecules of plasmin.	Polysaccharides	112-126	plasminogen	Homo sapiens	52-59
7074659-0	1982	Structural investigation of the capsular polysaccharide from Klebsiella serotype K-34 and its characterization by N.M.R.	Polysaccharides	41-55	keratin 34	Homo sapiens	81-85
7059522-0	1982	A novel semi-synthetic sulphated polysaccharide with potent antithrombin activity.	Polysaccharides	33-47	serpin family C member 1	Homo sapiens	60-72
7059522-3	1982	The sulphated polysaccharide (S-Lim) displayed an anticoagulant activity in a thrombin test system with human plasma.	Polysaccharides	14-28	PDZ and LIM domain 5	Homo sapiens	32-35
7059522-3	1982	The sulphated polysaccharide (S-Lim) displayed an anticoagulant activity in a thrombin test system with human plasma.	Polysaccharides	14-28	coagulation factor II, thrombin	Homo sapiens	78-86
6961914-0	1982	Effect of extracellular polysaccharides on diffusion of NaF and [14C]-sucrose in human dental plaque and in sediments of the bacterium Streptococcus sanguis 804 (NCTC 10904).	Polysaccharides	24-39	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
6802687-6	1982	The latent activity of the acid lysosomal alpha-glucosidase increases during the course of cell culture and especially when glycogen accumulates, suggesting that this enzyme could be involved in the control of the polysaccharide storage within the cell.	Polysaccharides	214-228	alpha glucosidase	Homo sapiens	32-59
7035561-0	1982	Cross-reactivity with Escherichia coli K100 in the human serum anticapsular antibody response to Haemophilus influenzae type B. Escherichia coli K100 is known to induce antibodies cross-reactive with the capsular polysaccharide (CP) of Haemophilus influenzae b (Hib); the cross-immunogenicity is found consistently in a number of mammalian species including man.	Polysaccharides	213-227	complement C1q like 3	Homo sapiens	39-43
7035561-0	1982	Cross-reactivity with Escherichia coli K100 in the human serum anticapsular antibody response to Haemophilus influenzae type B. Escherichia coli K100 is known to induce antibodies cross-reactive with the capsular polysaccharide (CP) of Haemophilus influenzae b (Hib); the cross-immunogenicity is found consistently in a number of mammalian species including man.	Polysaccharides	213-227	complement C1q like 3	Homo sapiens	145-149
7199046-1	1982	Structure of the capsular and extracellular polysaccharides of Rhizobium japonicum that bind soybean lectin.	Polysaccharides	44-59	LOW QUALITY PROTEIN: lectin	Glycine max	101-107
6809336-8	1982	Inasmuch as the polysaccharide of beta yolk spheres has the properties of glycogen (e.g., rosette structure digested by alpha-amylase) and the radiolabelled monosaccharides were introduced intra-abdominally, it is evident that transport systems as well as enzymes utilizing glucose and galactose for glycogenesis must be readily available.	Polysaccharides	16-30	Amylase proximal	Drosophila melanogaster	120-133
7060557-0	1982	Primary structure of the glycans from human lactotransferrin.	Polysaccharides	25-32	lactotransferrin	Homo sapiens	44-60
7060557-1	1982	The polypeptide chain of human lactotransferrin possesses two glycoslyation sites to which glycans are linked through an N-(beta-aspartyl)-N-acetylglucosaminylamine bond and which are structurally heterogenous.	Polysaccharides	91-98	lactotransferrin	Homo sapiens	31-47
6801813-10	1982	Thus, the high degree of heterogeneity of the FVIII/vWf carbohydrate moiety requires further structural studies in order to precise which class of glycans is involved in the biological activity of FVIII/vWf.	Polysaccharides	147-154	coagulation factor VIII	Homo sapiens	46-51
6801813-10	1982	Thus, the high degree of heterogeneity of the FVIII/vWf carbohydrate moiety requires further structural studies in order to precise which class of glycans is involved in the biological activity of FVIII/vWf.	Polysaccharides	147-154	von Willebrand factor	Homo sapiens	52-55
6801813-10	1982	Thus, the high degree of heterogeneity of the FVIII/vWf carbohydrate moiety requires further structural studies in order to precise which class of glycans is involved in the biological activity of FVIII/vWf.	Polysaccharides	147-154	coagulation factor VIII	Homo sapiens	197-202
6801813-10	1982	Thus, the high degree of heterogeneity of the FVIII/vWf carbohydrate moiety requires further structural studies in order to precise which class of glycans is involved in the biological activity of FVIII/vWf.	Polysaccharides	147-154	von Willebrand factor	Homo sapiens	203-206
6462134-6	1981	Heparin at a molar concentration well below that of plasmin still accelerates the reaction: one molecule of the polysaccharide is able to facilitate the inactivation of about 100 molecules of plasmin.	Polysaccharides	112-126	plasminogen	Homo sapiens	192-199
6788768-6	1981	Furthermore, the glycosaminoglycan component of C1q inhibitor was eluted from Sepharose CL-6B with a Kav of 0.52, indicating that these polysaccharide chains are considerably larger than those of human articular cartilage proteoglycan.	Polysaccharides	136-150	complement C1q A chain	Homo sapiens	48-51
7320060-3	1981	Many plastics, polysaccharides, metals, and ceramics were found to support cell growth as well as the fibronectin-dependent attachment of cells.	Polysaccharides	15-30	fibronectin 1	Homo sapiens	102-113
7020047-5	1981	Danish type 19A (type 57 in the United States system) polysaccharide contains this repeating unit and, in addition, has side chains of N-acetylglucosamine-galactose phosphate and fucose phosphate.	Polysaccharides	54-68	SLAM family member 7	Homo sapiens	12-15
6792684-4	1981	Furthermore, chemical analysis of glycans released from F VIII/vWf by alkaline-borohydride treatment or hydrazinolysis shows the absence of N-acetylgalactosamine residues in non-reducing terminal positions.	Polysaccharides	34-41	coagulation factor VIII	Homo sapiens	56-62
6792684-4	1981	Furthermore, chemical analysis of glycans released from F VIII/vWf by alkaline-borohydride treatment or hydrazinolysis shows the absence of N-acetylgalactosamine residues in non-reducing terminal positions.	Polysaccharides	34-41	von Willebrand factor	Homo sapiens	63-66
6113018-0	1981	Effect of sulphated polysaccharides on the alpha 1-antitrypsin inhibition of amidolysis catalysed by coagulation cascade proteinases.	Polysaccharides	20-35	serpin family A member 1	Homo sapiens	43-62
6113018-1	1981	1 The ability of several sulphated polysaccharide anticoagulants to prevent alpha 1-antitrypsin inhibition of thrombin paralleled their ability to potentiate antithrombin III inhibition of thrombin.	Polysaccharides	35-49	serpin family A member 1	Homo sapiens	76-95
6113018-1	1981	1 The ability of several sulphated polysaccharide anticoagulants to prevent alpha 1-antitrypsin inhibition of thrombin paralleled their ability to potentiate antithrombin III inhibition of thrombin.	Polysaccharides	35-49	coagulation factor II, thrombin	Homo sapiens	110-118
6113018-1	1981	1 The ability of several sulphated polysaccharide anticoagulants to prevent alpha 1-antitrypsin inhibition of thrombin paralleled their ability to potentiate antithrombin III inhibition of thrombin.	Polysaccharides	35-49	serpin family C member 1	Homo sapiens	158-174
6113018-1	1981	1 The ability of several sulphated polysaccharide anticoagulants to prevent alpha 1-antitrypsin inhibition of thrombin paralleled their ability to potentiate antithrombin III inhibition of thrombin.	Polysaccharides	35-49	coagulation factor II, thrombin	Homo sapiens	162-170
6113018-3	1981	2 These results are consistent with the possibility that a direct polysaccharide-proteinase interaction may be involved in the sulphated polysaccharide-modulated inhibition of thrombin by antithrombin III.	Polysaccharides	66-80	coagulation factor II, thrombin	Homo sapiens	176-184
6113018-3	1981	2 These results are consistent with the possibility that a direct polysaccharide-proteinase interaction may be involved in the sulphated polysaccharide-modulated inhibition of thrombin by antithrombin III.	Polysaccharides	66-80	serpin family C member 1	Homo sapiens	188-204
7018908-6	1981	The transglycosylase released galactose-labeled X + X" muropeptides early during the course of digestion, suggesting exoenzymatic cleavage of the glycan chains preferentially from the N-acetylglucosaminyl ends.	Polysaccharides	146-152	transglycosylase	Escherichia coli	4-20
7215671-0	1981	Effect of dithiothreitol on the modulation of antithrombin III activity by sulphated polysaccharides.	Polysaccharides	85-100	serpin family C member 1	Homo sapiens	46-62
6914196-3	1981	Inactivation of Factor Xa, Factor XIIa and kallikrein was, however, less dependent on the size of the polysaccharide and, to a great extent, was potentiated even by low-molecular-weight heparin fractions that had virtually no effect on the inhibition of thrombin, Factor IXa and Factor XIa.	Polysaccharides	102-116	coagulation factor X	Homo sapiens	16-25
7193204-0	1981	Localization and partial characterization of soybean lectin-binding polysaccharide of Rhizobium japonicum.	Polysaccharides	68-82	LOW QUALITY PROTEIN: lectin	Glycine max	53-59
6914196-3	1981	Inactivation of Factor Xa, Factor XIIa and kallikrein was, however, less dependent on the size of the polysaccharide and, to a great extent, was potentiated even by low-molecular-weight heparin fractions that had virtually no effect on the inhibition of thrombin, Factor IXa and Factor XIa.	Polysaccharides	102-116	kallikrein related peptidase 4	Homo sapiens	43-53
7193204-4	1981	Electron microscopic observation of the cell-gel complex after labeling with soybean lectin-ferritin conjugate revealed that capsular polysaccharides, frequently attached to one end of the cells, were receptors for lectin.	Polysaccharides	134-149	LOW QUALITY PROTEIN: lectin	Glycine max	85-91
7193204-4	1981	Electron microscopic observation of the cell-gel complex after labeling with soybean lectin-ferritin conjugate revealed that capsular polysaccharides, frequently attached to one end of the cells, were receptors for lectin.	Polysaccharides	134-149	LOW QUALITY PROTEIN: lectin	Glycine max	215-221
7193204-7	1981	Lectin binding was restricted to a polysaccharide component designated as lectin-binding polysaccharide.	Polysaccharides	35-49	LOW QUALITY PROTEIN: lectin	Glycine max	0-6
7193204-7	1981	Lectin binding was restricted to a polysaccharide component designated as lectin-binding polysaccharide.	Polysaccharides	35-49	LOW QUALITY PROTEIN: lectin	Glycine max	74-80
7193204-7	1981	Lectin binding was restricted to a polysaccharide component designated as lectin-binding polysaccharide.	Polysaccharides	89-103	LOW QUALITY PROTEIN: lectin	Glycine max	0-6
7193204-7	1981	Lectin binding was restricted to a polysaccharide component designated as lectin-binding polysaccharide.	Polysaccharides	89-103	LOW QUALITY PROTEIN: lectin	Glycine max	74-80
7193204-9	1981	It was concluded that the soybean lectin-binding component of R. japonicum is an extracellular polysaccharide and not a lipopolysaccharide and that the diffusible lectin-binding polysaccharide probably differs from the very high-molecular-weight lectin-binding polysaccharide of the loose capsule (slime) only in the degree of polymerization.	Polysaccharides	95-109	LOW QUALITY PROTEIN: lectin	Glycine max	34-40
6162639-6	1981	Moreover it was demonstrated that each alpha 1-fetoprotein variant contained either two glycans 1a or two glycans 2a, not randomly, but a pair of the identical carbohydrate chains at the two glycosylation sites.	Polysaccharides	88-95	alpha-fetoprotein	Rattus norvegicus	39-58
7266483-0	1981	The interaction of two polysaccharides containing beta 1,6-linked galactopyranosyl residues with two monoclonal antigalactan immunoglobulin Fab" fragments.	Polysaccharides	23-38	FA complementation group B	Homo sapiens	140-143
7271662-4	1981	When the polysaccharide materials were subjected to gel filtration on Sepharose 6B by tracing at 280 and 490 nm, the protective and toxic activities could be fractionated as peak-1 and -2 polysaccharides, respectively.	Polysaccharides	9-23	pseudopodium enriched atypical kinase 1	Gallus gallus	174-187
7271662-5	1981	The fraction of peak-1 polysaccharides from strains 221 and S1 was eluted at void volume.	Polysaccharides	23-38	pseudopodium enriched atypical kinase 1	Gallus gallus	16-22
6162639-6	1981	Moreover it was demonstrated that each alpha 1-fetoprotein variant contained either two glycans 1a or two glycans 2a, not randomly, but a pair of the identical carbohydrate chains at the two glycosylation sites.	Polysaccharides	106-113	alpha-fetoprotein	Rattus norvegicus	39-58
6452123-0	1980	Interaction of lipoprotein lipase with native and modified heparin-like polysaccharides.	Polysaccharides	72-87	lipoprotein lipase	Rattus norvegicus	15-33
7438136-2	1980	Nimmich has analyzed the capsular polysaccharide of Klebsiella K53 and has shown that it belongs to the chemotype that also comprises K40 and K80.	Polysaccharides	34-48	keratin 40	Homo sapiens	134-137
7438136-2	1980	Nimmich has analyzed the capsular polysaccharide of Klebsiella K53 and has shown that it belongs to the chemotype that also comprises K40 and K80.	Polysaccharides	34-48	keratin 80	Homo sapiens	142-145
7438137-0	1980	Structure of the capsular polysaccharide of Klebsiella serotype K74.	Polysaccharides	26-40	keratin 74	Homo sapiens	64-67
7438137-1	1980	The capsular polysaccharide of Klebsiella serotype K74 belongs to a chemogroup consisting of seven strains, of which four contain 1-carboxyethylidene groups (pyruvic acid acetals).	Polysaccharides	13-27	keratin 74	Homo sapiens	51-54
7438137-3	1980	The capsular polysaccharide from Klebsiella K74 is composed of D-glucuronic acid, D-galactose, and D-mannose, and this chemotype includes a total of seven strains, of which four have 1-carboxyethylidene groups (pyruvic acid acetals).	Polysaccharides	13-27	keratin 74	Homo sapiens	44-47
7438137-4	1980	In this chemogroup, the structures of the capsular polysaccharides of the serotypes K20 (ref.	Polysaccharides	51-66	keratin 20	Homo sapiens	84-87
6450073-0	1980	Modification by anionic polysaccharides of the antithrombin III inhibition of plasmin.	Polysaccharides	24-39	serpin family C member 1	Homo sapiens	47-63
6450073-0	1980	Modification by anionic polysaccharides of the antithrombin III inhibition of plasmin.	Polysaccharides	24-39	plasminogen	Homo sapiens	78-85
6452123-17	1980	The ability of the polysaccharides to release lipoprotein lipase to the circulating blood after intravenous injection into rats essentially conformed to their affinity for the enzyme as evaluated by the experiments in vitro.	Polysaccharides	19-34	lipoprotein lipase	Rattus norvegicus	46-64
6771279-0	1980	The structures of the cross-reactive types 19 (19F) and 57 (19A) pneumococcal capsular polysaccharides.	Polysaccharides	87-102	SLAM family member 7	Homo sapiens	60-63
6159941-1	1980	1 Comparison of the effects of sulphated polysaccharides on thrombin-induced clotting of normal and antithrombin III-deficient plasmas suggests the involvement of antithrombin III (AT III) in the anticoagulant activities of cellulose, dextran and xylan sulphates.	Polysaccharides	41-56	coagulation factor II, thrombin	Homo sapiens	60-68
6771279-2	1980	Both polysaccharides exhibit an identical structure of 4)-beta-2-acetamido-2-deoxymannose-(1 leads to 4)-alpha-D-glucose-(1 leads to 2)-alpha-L-rhamnose-1-phosphate.	Polysaccharides	5-20	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	58-64
6771279-4	1980	The type 57 polysaccharide contains this same repeating unit and side chains composed of a beta-D-2-acetamido-2-deoxyglucose-(1 leads to 3)-beta-D-galactose-1-phosphate side chain attached to C-2 of the glucose and an alpha-L-fucose-1-phosphate attached to C-3 of the rhamnose.	Polysaccharides	12-26	complement C2	Homo sapiens	192-195
7407676-4	1980	The PA 1 cells contained also oligomannosyl type glycans, presumably linked to asparagine (fraction C glycopeptides).	Polysaccharides	49-56	PAXIP1 associated glutamate rich protein 1	Homo sapiens	4-8
7444858-0	1980	Inhibition of thrombin on surfaces coated with immobilized heparin and heparin-like polysaccharides: a crucial non-thrombogenic principle.	Polysaccharides	84-99	coagulation factor II, thrombin	Homo sapiens	14-22
6155418-0	1980	The effect of a sulfated polysaccharide on antithrombin III.	Polysaccharides	25-39	serpin family C member 1	Homo sapiens	43-59
7371042-1	1980	The capsular polysaccharide of Klebsiella serotype K27 had been investigated by techniques involving methylation analysis, autohydrolysis, and graded hydrolysis with acid.	Polysaccharides	13-27	keratin 27	Homo sapiens	51-54
16661379-4	1980	In both strains the proportion of galactose to methyl galactose is considerably greater in the polysaccharide from bacteria which do bind lectin than in the polysaccharide from bacteria which do not bind lectin.In addition to the changes in polysaccharide composition, there is a reduction of about 50% in the percentage of cells which are encapsulated as the cultures mature from early to late log phase.	Polysaccharides	95-109	LOW QUALITY PROTEIN: lectin	Glycine max	138-144
16345578-0	1980	Accumulation of Soybean Lectin-Binding Polysaccharide During Growth of Rhizobium japonicum as Determined by Hemagglutination Inhibition Assay.	Polysaccharides	39-53	LOW QUALITY PROTEIN: lectin	Glycine max	24-30
16345578-1	1980	A hemagglutination inhibition assay was used to estimate the presence of soybean lectin-binding polysaccharide in whole culture, culture supernatant, and isolated exopolysaccharide of Rhizobium japonicum USDA 138.	Polysaccharides	96-110	LOW QUALITY PROTEIN: lectin	Glycine max	81-87
16345578-2	1980	The occurrence of 0.1 to 0.2 mug of lectin-binding polysaccharide could be detected within 2 h with a 0.5-ml total sample.	Polysaccharides	51-65	LOW QUALITY PROTEIN: lectin	Glycine max	36-42
16345578-3	1980	Lectin-binding polysaccharide was detected in all preparations during both exponential and stationary growth phases.	Polysaccharides	15-29	LOW QUALITY PROTEIN: lectin	Glycine max	0-6
16345578-4	1980	The formation of lectin-binding polysaccharide was not, whereas that of total exopolysaccharide was, markedly affected by culture conditions.	Polysaccharides	32-46	LOW QUALITY PROTEIN: lectin	Glycine max	17-23
7407676-5	1980	These glycopeptides were strongly bound to Con A--Sepharose and their oligosaccharides were released by endo-beta-N-acetylglucosaminidase H. The liberated glycans ranged from Man5GlcNAc to Man9GlcNAc as analyzed by paper chromatography.	Polysaccharides	155-162	mannosidase alpha class 1A member 1	Homo sapiens	189-193
16661104-3	1979	To study the synthesis of this polysaccharide, a technique for isolating and assaying GDP-fucose:polysaccharide fucosyl transferase activity was developed.	Polysaccharides	31-45	Omega-hydroxypalmitate O-feruloyl transferase	Zea mays	120-131
7378456-1	1980	Human lactotransferrin contains two prosthetic sugar groups situated in two different cyanogen bromide fragments: the amino acid sequences around the two polysaccharide attachment sites were established.	Polysaccharides	154-168	lactotransferrin	Homo sapiens	6-22
6102938-0	1980	Effect of sulphated polysaccharides on clotting of plasma deficient in antithrombin III [proceedings].	Polysaccharides	20-35	serpin family C member 1	Homo sapiens	71-87
7358983-0	1980	Differentiation of hemolytically active fluid-phase and cell-bound human C1q by an ant venom-derived polysaccharide.	Polysaccharides	101-115	complement C1q A chain	Homo sapiens	73-76
6991418-6	1980	Since the glycan backbone and the tetrapeptide (pentapeptide) subunit of the peptidoglycan of all staphylococcal strains tested are believed to be identical, it is suggested that IgE binding is related to either the peptidoglycan interpeptide bridge or an unknown antigenic structure within the cell wall of S. aureus.	Polysaccharides	10-16	immunoglobulin heavy constant epsilon	Homo sapiens	179-182
7378496-1	1980	Modification of pancreatic trypsin inhibitor by soluble polysaccharides activated by titanium tetrachloride].	Polysaccharides	56-71	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	27-44
7378496-3	1980	A method for obtaining soluble preparations of pancreatic trypsin inhibitor bound to the activated polysaccharide matrix completely retaining its inhibiting activity was developed.	Polysaccharides	99-113	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	58-75
6154613-0	1980	Involvement of antithrombin III in anticoagulant effects of sulphated polysaccharides [proceedings].	Polysaccharides	70-85	serpin family C member 1	Homo sapiens	15-31
6446659-1	1980	The autodiploid strain of Pullularia pullulans 1125(4)(13) that differs from the haploid strain 1125(4) in the rate of synthesis of the polysaccharide pullulan has a higher activity of hexokinase in cell-free preparations.	Polysaccharides	136-150	hexokinase 1	Homo sapiens	185-195
6446659-2	1980	A change in the activity of hexokinase in the diploid strain coincides in time with a change in the rate of the polysaccharide synthesis: the activity of hexokinase in cell-free preparations is highest when the rate of pullulan synthesis is maximal.	Polysaccharides	112-126	hexokinase 1	Homo sapiens	28-38
6446659-2	1980	A change in the activity of hexokinase in the diploid strain coincides in time with a change in the rate of the polysaccharide synthesis: the activity of hexokinase in cell-free preparations is highest when the rate of pullulan synthesis is maximal.	Polysaccharides	112-126	hexokinase 1	Homo sapiens	154-164
469042-6	1979	The polysaccharide part of ovine kappa-casein resembles that of bovine kappa-casein, but contains also N-glycolyl neuraminic acid.	Polysaccharides	4-18	casein kappa	Bos taurus	33-45
380992-11	1979	The glycan moiety of lipase is bound to Asn-166.	Polysaccharides	4-10	lipase	Staphylococcus aureus	21-27
465705-2	1979	Under conditions of stimulation with the bacterial polysaccharide prodigiosan, the resistance of hepatocytes to CCl4 sharply increased, which was shown by diminished severity of hepatic parenchyma destruction.	Polysaccharides	51-65	C-C motif chemokine ligand 4	Rattus norvegicus	112-116
534538-2	1979	Of the asialo-transferrins, type 1 was derived from the principal DEAE-cellulose chromatographic component of transferrin, i.e. the one that contains two biantennary glycans.	Polysaccharides	166-173	transferrin	Homo sapiens	14-25
534538-5	1979	Glycan structures responsible for the difference in binding strengths between asialo-transferrin types 2 and 3 are not known.	Polysaccharides	0-6	transferrin	Homo sapiens	85-96
574451-0	1979	Investigation by 360-MHz 1H-nuclear-magnetic-resonance spectroscopy and methylation analysis of the single glycan chain of chicken ovotransferrin.	Polysaccharides	107-113	transferrin (ovotransferrin)	Gallus gallus	131-145
760827-5	1979	The bi-antennary glycan liberated from the reference glycopiptide GC-4 was of 1750 daltons.	Polysaccharides	17-23	N-myc downstream regulated 1	Homo sapiens	66-70
425611-1	1979	The human serum proteins C-reactive protein (CRP), the 9.5 Salpha1-glycoprotein and C1q show, when tested in the agar gel diffusion under certain buffer conditions, strong precipitin reactions with polysaccharides of the galactan type, indicating that they may have lectin-like recognition sites.	Polysaccharides	198-213	C-reactive protein	Homo sapiens	25-43
425611-1	1979	The human serum proteins C-reactive protein (CRP), the 9.5 Salpha1-glycoprotein and C1q show, when tested in the agar gel diffusion under certain buffer conditions, strong precipitin reactions with polysaccharides of the galactan type, indicating that they may have lectin-like recognition sites.	Polysaccharides	198-213	C-reactive protein	Homo sapiens	45-48
425611-1	1979	The human serum proteins C-reactive protein (CRP), the 9.5 Salpha1-glycoprotein and C1q show, when tested in the agar gel diffusion under certain buffer conditions, strong precipitin reactions with polysaccharides of the galactan type, indicating that they may have lectin-like recognition sites.	Polysaccharides	198-213	complement C1q A chain	Homo sapiens	84-87
114170-2	1979	Adsorptive endocytosis of alpha-N-acetylglucosaminidase from human urine by isolated rat hepatocytes is inhibited by glycoproteins, polysaccharides and sugars that are known to bind to cell-surface receptors specific for either terminal galactose/N-acetylgalactosamine residues, terminal mannose residues or mannose 6-phosphate residues.	Polysaccharides	132-147	N-acetyl-alpha-glucosaminidase	Homo sapiens	26-55
708003-0	1978	[Characteristics of the polysaccharide-containing somatic antigens isolated from the K-1 strain of the plague microbe and its antibiotic-resistant variants].	Polysaccharides	24-38	keratin 1	Homo sapiens	85-88
546134-0	1979	Protective effect of PSK, a protein-bound polysaccharide preparation against candidiasis in tumor-bearing mice.	Polysaccharides	42-56	TAO kinase 2	Mus musculus	21-24
83302-4	1978	Both types 19F(19) and 19A(57) polysaccharides contained trace amounts of protein and nucleic acid and had comparable molecular sizes as determined by gel filtration.	Polysaccharides	31-46	SLAM family member 7	Homo sapiens	23-26
732367-6	1978	It is concluded that not all of the polysaccharide moiety of the proteoglycan is involved in binding of the vegetalizing factor.	Polysaccharides	36-50	versican	Gallus gallus	65-77
121198-3	1979	These data lead favorably to consider that among the five polysaccharides tested under the present experimental model LTN and PSK are the most potent activators of resident mouse peritoneal macrophages in vitro.	Polysaccharides	58-73	TAO kinase 2	Mus musculus	126-129
425377-4	1979	Presence of heparin did not influence on the sulfite method but the polysaccharide might interfere in the thrombin method.	Polysaccharides	68-82	coagulation factor II, thrombin	Homo sapiens	106-114
103656-0	1978	[Spatial conformation of human serotransferrin glycans].	Polysaccharides	47-54	transferrin	Homo sapiens	31-46
708003-4	1978	Defective changes in the monosaccharide composition and serological properties of both the main somatic antigen and the polysaccharide were observed in the yellow variant of the streptomycin resistant mutant K-1.	Polysaccharides	120-134	keratin 1	Homo sapiens	208-211
710579-0	1978	Structure determination of the single glycan of rabbit serotransferrin by methylation analysis and 360 MHz 1H NMR spectroscopy.	Polysaccharides	38-44	serotransferrin	Oryctolagus cuniculus	55-70
27377-0	1978	Interaction of an alkali stable polysaccharide from cell surface of Staphylococci with human fibrinogen.	Polysaccharides	32-46	fibrinogen beta chain	Homo sapiens	93-103
668697-5	1978	The chemical shifts of the anomeric and mannose H-2 protons give information about the type of glycan structure (mono-, bi-, triantennary) and the presence of terminal sialic acid at each of the antennas.	Polysaccharides	95-101	relaxin 2	Homo sapiens	48-51
351621-4	1978	Nonendotoxic, lipid-free, and polysaccharide-rich hydrolytic breakdown product of LPS (called PS) was less potent but still active in CSF induction.	Polysaccharides	30-44	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	134-137
150778-2	1978	The purified AIF was a polysaccharide which was formed from a low molecular substance Pro-AIF by macromolecularization.	Polysaccharides	23-37	apoptosis inducing factor, mitochondria associated 1	Rattus norvegicus	13-16
150778-2	1978	The purified AIF was a polysaccharide which was formed from a low molecular substance Pro-AIF by macromolecularization.	Polysaccharides	23-37	apoptosis inducing factor, mitochondria associated 1	Rattus norvegicus	90-93
403204-0	1977	Demonstration of bacterial capsular polysaccharide in CSF by counter immunoelectrophoresis.	Polysaccharides	36-50	colony stimulating factor 2	Homo sapiens	54-57
355037-5	1978	EPF was composed of approximately 74.5% of protein, 20.4% of lipid, and a small amount of polysaccharide.	Polysaccharides	90-104	epileptiform	Mus musculus	0-3
620059-7	1978	The lectin is nonspecific in human erythrocyte ABO system, it is not inhibited by simple sugars but is inhibited by a partial hydrolysate of chitin-containing mixture of polysaccharides from Aspergillus niger.	Polysaccharides	170-185	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	47-50
202660-3	1978	A more practical approach is the specific precipitation of apolipoprotein B (apoB)-containing lipoproteins by sulfated polysaccharides and divalent cations, heparin-Mn(2+) being the most commonly used combination.	Polysaccharides	119-134	apolipoprotein B	Homo sapiens	59-75
202660-3	1978	A more practical approach is the specific precipitation of apolipoprotein B (apoB)-containing lipoproteins by sulfated polysaccharides and divalent cations, heparin-Mn(2+) being the most commonly used combination.	Polysaccharides	119-134	apolipoprotein B	Homo sapiens	77-81
907920-5	1977	Extracellular polysaccharides of strain 138 reacted with soybean lectin in gel diffusion tests, so that the EPS seen in electron micrographs is tentatively considered to include the lectin-binding material.	Polysaccharides	14-29	LOW QUALITY PROTEIN: lectin	Glycine max	65-71
907920-5	1977	Extracellular polysaccharides of strain 138 reacted with soybean lectin in gel diffusion tests, so that the EPS seen in electron micrographs is tentatively considered to include the lectin-binding material.	Polysaccharides	14-29	LOW QUALITY PROTEIN: lectin	Glycine max	182-188
330813-0	1977	Genetic determinants of the synthesis of the polysaccharide capsular antigen K27(A) of Escherichia coli.	Polysaccharides	45-59	keratin 27	Homo sapiens	77-80
857923-4	1977	The cellulose with the H2NO-groups located at considerable distances from the polysaccharide matrix, form the "aminotransferase oxime--aminooxycellulose" complex, which is subsequently split either to a choloenzyme or apoenzyme of PLP and aminooxycellulose, depending on the experimental conditions used.	Polysaccharides	78-92	proteolipid protein 1	Homo sapiens	231-234
880205-0	1977	The mode of hydrolysis of a glycan portion of Micrococcus lysodeikticus cell walls by endo-N-acetylglucosaminidase or endo-N-acetylmuramidase isolated from crude barley beta-amylase.	Polysaccharides	28-34	1,4-alpha-D-glucan maltohydrolase	Hordeum vulgare	169-181
204293-1	1978	By enzymic digestion of the polysaccharide part of the covalent complex between cytochrome c and Sephadex G-200, a new water-soluble cytochrome c derivative is obtained (called cytochrome cr).	Polysaccharides	28-42	cytochrome c, somatic	Homo sapiens	80-92
204293-1	1978	By enzymic digestion of the polysaccharide part of the covalent complex between cytochrome c and Sephadex G-200, a new water-soluble cytochrome c derivative is obtained (called cytochrome cr).	Polysaccharides	28-42	cytochrome c, somatic	Homo sapiens	133-145
600587-0	1977	[Histochemical studies of polysaccharides in melanocytes following trypsin and neuraminidase digestion of their membranes].	Polysaccharides	26-41	neuraminidase 1	Homo sapiens	79-92
406922-4	1977	A substance that is identical or closely similar to membrane teichoic acid, lipoteichoic acid carrier, plays an important part in the  biosynthesis of wall teichoic acid; it accepts polyol phosphate residues from CDP-glycerol or CDP-ribitol to form a polyol phosphate chain which is then transferred after the incorporation of a tri(glycerol phosphate) linkage unit, to the growing glycan chain of peptidoglycan.	Polysaccharides	382-388	cut like homeobox 1	Homo sapiens	213-216
406922-4	1977	A substance that is identical or closely similar to membrane teichoic acid, lipoteichoic acid carrier, plays an important part in the  biosynthesis of wall teichoic acid; it accepts polyol phosphate residues from CDP-glycerol or CDP-ribitol to form a polyol phosphate chain which is then transferred after the incorporation of a tri(glycerol phosphate) linkage unit, to the growing glycan chain of peptidoglycan.	Polysaccharides	382-388	cut like homeobox 1	Homo sapiens	229-232
869924-10	1977	The difference in polysaccharide content of the subcomponents C-1r and C-1s is most marked in the "b" chains.	Polysaccharides	18-32	complement C1r	Homo sapiens	62-66
848918-0	1977	[Effect of a polysaccharide-contaning preparation from El Tor vibrions on the phagocytic activity of leukocytes and on the lysozyme titer].	Polysaccharides	13-27	tortured	Mus musculus	58-61
848918-3	1977	The results of the study showed that administration of the polysaccharide-containing preparations from El-Tor vibrios in doses of 50 and 500 gemma/mouse was accompanied by some shifts in the regulatory mechanisms: suppression of the serum lysozyme activity on the 1st and 3rd days and its stimulation on the 7th and 10th days.	Polysaccharides	59-73	tortured	Mus musculus	106-109
995886-0	1976	[Catalase inactivation during storage in solution and its stabilization by polysaccharides of microbial origin].	Polysaccharides	75-90	catalase	Homo sapiens	1-9
1017585-1	1976	The protein-bound polysaccharide preparation, PS-K, isolated from a mushroom, Coriolus versicolor, was found to stimulate human lymphocytes and induce them into blastogenesis in vitro.	Polysaccharides	18-32	TAO kinase 2	Homo sapiens	46-50
857775-2	1977	It has been shown that in its histochemical properties the secreted mucin is similar to mucous secretions of the enterodermal lining of the mammalian stomach and contains neutral polysaccharides, sulfo- and slilosaccharides.	Polysaccharides	179-194	LOC100508689	Homo sapiens	68-73
1033034-8	1976	ESG consist of protein with some polysaccharides; ASG are composed of protein carbohydrate complexes and lack catecholamines; ICG contain catecholamine as well as protein carbohydrate complexes.	Polysaccharides	33-48	TLE family member 2, transcriptional corepressor	Homo sapiens	0-3
995886-4	1976	Polysaccharides of microbial origin can also stabilize catalase.	Polysaccharides	0-15	catalase	Homo sapiens	55-63
995886-5	1976	The kinetics of catalase inactivation in the system where the enzyme and polysaccharide forms a reversibly dissociating complex has been described.	Polysaccharides	73-87	catalase	Homo sapiens	16-24
176334-7	1976	Some of the degrading enzymes studied-beta-glucuronidase, hyaluronidase and aryl sulphatase-were highest in the sucrose group and generally lowest in the polysaccharide group.	Polysaccharides	154-168	glucuronidase, beta	Rattus norvegicus	38-56
1097420-2	1975	The mnn2 mutation, which affects the addition to the polysaccharide backbone of the first side-chain D-mannose unit in alpha1-leads to2 linkage, was located on chromosome II linked to the centromere and the gall locus.	Polysaccharides	53-67	alpha-1,2-mannosyltransferase MNN2	Saccharomyces cerevisiae S288C	4-8
773734-1	1976	The protein-bound polysaccharide preparation, PS-K, was found to potentiate the production of hemolytic plaque-forming cells of spleen and serum hemagglutinin in C57BL/6 mice, when they were immunized with a low dose of sheep red blood cells.	Polysaccharides	18-32	TAO kinase 2	Mus musculus	46-50
130494-0	1976	Effect of PS-K, a protein polysaccharide, on pulmonary metastases of a C3H mouse squamous cell carcinoma.	Polysaccharides	26-40	TAO kinase 2	Mus musculus	10-14
131730-1	1975	The protein-bound polysaccharide preparation, PS-K, was found to possess an antitumor effect against 3-methylcholanthrene-induced fibrosarcoma in mice which was shown to have a tumor-specific transplantation antigen.	Polysaccharides	18-32	TAO kinase 2	Mus musculus	46-50
791775-6	1976	The observed results support the hypothesis that in the mnn 1 the mutation has altered the structural gene involved in biosynthesis of an alpha(1 leads to 3) mannosyl transferase catalyzing the addition of alpha(1 leads to 3) linked mannosyl units to alpha(1 leads to 2) linked mannotrioses in the polysaccharide side chains and in the oligosaccharides attached to serine and/or threonine in the protein part of mannan molecule.	Polysaccharides	298-312	alpha-1,3-mannosyltransferase MNN1	Saccharomyces cerevisiae S288C	56-61
791775-7	1976	The mnn 2 mutant represents most probably a kind of regulatory mutation where the activity of an alpha(1 leads to 2) mannosyl transferase adding the mannosyl units directly to alpha(1 leads to 6) linked backbone in the outer region of polysaccharide part of yeast mannan is repressed in vivo but becomes significant in vitro.	Polysaccharides	235-249	alpha-1,2-mannosyltransferase MNN2	Saccharomyces cerevisiae S288C	4-9
1183773-1	1975	PS-K, a protein-bound polysaccharide from a basidiomycetes, was found to suppress tumor growth after grafting of sarcoma-180 or Ehrlich tumor in ICR mice.	Polysaccharides	22-36	TAO kinase 2	Mus musculus	0-4
166754-5	1975	These studies show that they polysaccharide consits  of thefollowing hexasaccharide repeating-unit: yield2)-alpha-L-Rhap-(1yields3)-alpha-L-Rhap-(1-yields4)-beta-D-GlcAP-(1-yields2)-alpha-L-Rhap-(1-yields3)-alpha-L-Rhap-(1-yields3)-beta-D-Galp-(1-yields.	Polysaccharides	29-43	galanin like peptide	Homo sapiens	239-243
239055-5	1975	With polysaccharide-deficient rough mutants of salmonella minnesota, the CSF-inducing activity could be restricted to the "core" region of the LPS structure.	Polysaccharides	5-19	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	73-76
4138971-0	1974	[Immunochemical studies on two polysaccharides extracted from Salmonella johannesburg 5.58 wild strain and Salmonella johannesburg 5.58 transformed by phage phi 1 (40)].	Polysaccharides	31-46	protein phosphatase 1 regulatory inhibitor subunit 14B	Homo sapiens	157-162
46329-10	1975	The basic structure of these polysaccharides is thus similar to that of normal sulfated mucin.	Polysaccharides	29-44	LOC100508689	Homo sapiens	88-93
16742806-8	1973	The resulting newly synthesized polysaccharide was shown by chondroitinase ABC digestion to be 70% chondroitin 4-sulphate and 30% chondroitin.	Polysaccharides	32-46	carbohydrate sulfotransferase 11	Mus musculus	99-112
4137253-1	1974	Establishment of hyperimmunization with bovine serum albumin in mice treated with capsular polysaccharide of Klebsiella pneumoniae.	Polysaccharides	91-105	albumin	Mus musculus	53-60
4848334-0	1974	[Comparative evaluation of 2 polysaccharide-containing preparations of El Tor vibrions].	Polysaccharides	29-43	RAR related orphan receptor C	Homo sapiens	74-77
4756891-0	1973	Activities of sulfated polysaccharides in the liberation of lipoprotein lipase into the blood and inhibition of its activity.	Polysaccharides	23-38	lipoprotein lipase	Homo sapiens	60-78
5086108-0	1972	13 C magnetic resonance and structural studies on the mannose-containing polysaccharides of some Pichia and Hansenula spp.	Polysaccharides	73-88	histocompatibility minor 13	Homo sapiens	118-121
4266584-0	1973	Purification of cathepsin D from cartilage and uterus and its action on the protein-polysaccharide complex of cartilage.	Polysaccharides	84-98	cathepsin D	Homo sapiens	16-27
4309057-1	1969	The capsular polysaccharide of a strain, BD4, of Acinetobacter calco-aceticus (A.c-a), composed of L-rhamnose and D-glucose, 4:1, precipitates all streptococcal group B antisera tested, as well as streptococcal group G antisera and antipneumococcal (Pn) type XXIII serum.	Polysaccharides	13-27	defensin beta 104A	Homo sapiens	41-44
4260317-0	1972	Pepstatin inhibits the digestion of hemoglobin and protein-polysaccharide complex by cathepsin D.	Polysaccharides	59-73	cathepsin D	Homo sapiens	85-96
5150192-2	1971	When 75% of the dietary carbohydrate was derived from food containing polysaccharides, the mean plasma insulin response to oral glucose was decreased relative to that seen following complementary diets providing carbohydrate mainly as simple sugars.	Polysaccharides	70-85	insulin	Homo sapiens	103-110
11947330-3	1970	The glycan strand consists of alternating 1-->4 linked N-acetylglucosamine and N-glycolylmuramic acid residues substituted by a peptide subunit in which the aminoacids Ala, Glu, meso-Dap are present in the molar proportions 1,7:1,2:1.	Polysaccharides	4-10	death associated protein	Homo sapiens	186-189
4882020-1	1968	Strains of Escherichia coli carrying the gene lon typically produced excess capsular polysaccharide, and were sensitive to ultraviolet light (UV) irradiation, thymine starvation, and nalidixic acid, forming long filaments after these treatments.	Polysaccharides	85-99	putative ATP-dependent Lon protease	Escherichia coli	46-49
4237520-7	1969	Treatment of the cartilage residue or the water-insoluble protein polysaccharide called PPH, with neutral NH(2)OH solution releases water-soluble protein polysaccharides which in composition resemble PPL 4.	Polysaccharides	66-80	enolase 1	Homo sapiens	88-91
4237520-7	1969	Treatment of the cartilage residue or the water-insoluble protein polysaccharide called PPH, with neutral NH(2)OH solution releases water-soluble protein polysaccharides which in composition resemble PPL 4.	Polysaccharides	154-169	enolase 1	Homo sapiens	88-91
6033751-2	1967	Fragments from enzymic degradation of protein-polysaccharide light fraction (PPL) have been analysed.	Polysaccharides	46-60	periplakin	Bos taurus	77-80
5646624-7	1968	It would appear that this association between CRP and resistance, the antibacterial activity of CRP, and its action on the polysaccharides obtained from bacterial cell walls are evidence for the participation of CRP in nonspecific resistance to infection.	Polysaccharides	123-138	C-reactive protein, pentraxin-related	Mus musculus	46-49
5646624-7	1968	It would appear that this association between CRP and resistance, the antibacterial activity of CRP, and its action on the polysaccharides obtained from bacterial cell walls are evidence for the participation of CRP in nonspecific resistance to infection.	Polysaccharides	123-138	C-reactive protein, pentraxin-related	Mus musculus	96-99
5646624-7	1968	It would appear that this association between CRP and resistance, the antibacterial activity of CRP, and its action on the polysaccharides obtained from bacterial cell walls are evidence for the participation of CRP in nonspecific resistance to infection.	Polysaccharides	123-138	C-reactive protein, pentraxin-related	Mus musculus	96-99
4316250-2	1967	In fact, a mutant (G30/C21) which has lost all the polysaccharide side chains and sugars of the O antigen and contains only 2-keto-3-deoxyoctonate and lipid is indistinguishable in its interferon-stimulating ability from the wild type which possesses a complete O antigen with polysaccharide side chains.	Polysaccharides	51-65	transducin (beta)-like 1X-linked receptor 1	Mus musculus	23-26
4862194-0	1967	Derepression of phosphomannose isomerase by regulator gene mutations involved in capsular polysaccharide synthesis in Escherichia coli K-12.	Polysaccharides	90-104	mannose phosphate isomerase	Homo sapiens	16-40
4862194-1	1967	A regulator gene mutation (capR) that causes increased synthesis of capsular polysaccharide and derepressed synthesis of several enzymes involved in polysaccharide synthesis also derepresses phosphomannose isomerase (PMI) synthesis.	Polysaccharides	77-91	mannose phosphate isomerase	Homo sapiens	191-215
4862194-1	1967	A regulator gene mutation (capR) that causes increased synthesis of capsular polysaccharide and derepressed synthesis of several enzymes involved in polysaccharide synthesis also derepresses phosphomannose isomerase (PMI) synthesis.	Polysaccharides	77-91	mannose phosphate isomerase	Homo sapiens	217-220
4862194-1	1967	A regulator gene mutation (capR) that causes increased synthesis of capsular polysaccharide and derepressed synthesis of several enzymes involved in polysaccharide synthesis also derepresses phosphomannose isomerase (PMI) synthesis.	Polysaccharides	149-163	mannose phosphate isomerase	Homo sapiens	191-215
4862194-1	1967	A regulator gene mutation (capR) that causes increased synthesis of capsular polysaccharide and derepressed synthesis of several enzymes involved in polysaccharide synthesis also derepresses phosphomannose isomerase (PMI) synthesis.	Polysaccharides	149-163	mannose phosphate isomerase	Homo sapiens	217-220
6023570-1	1967	V. Reduction of cytochrome c by synthetic polysaccharides.	Polysaccharides	42-57	cytochrome c, somatic	Homo sapiens	16-28
13932349-2	1963	Correlation of plasma protein bound polysaccharides and plasmin system.	Polysaccharides	36-51	plasminogen	Homo sapiens	56-63
5967019-0	1966	Sulphuric esters of polysaccharides as activators of a bradykinin-forming system in plasma.	Polysaccharides	20-35	kininogen 1	Homo sapiens	55-65
13861311-0	1961	The effect of a sulphated polysaccharide upon the diffusion of pepsin through mucin.	Polysaccharides	26-40	LOC100508689	Homo sapiens	78-83
14006400-0	1962	Effects of a bacterial polysaccharide (Piromen) on the pituitary-adrenal axis: chronic cortisone blockade of Piromen-induced release of ACTH.	Polysaccharides	23-37	proopiomelanocortin	Homo sapiens	136-140
14414350-0	1960	An unusual polysaccharide in chondroid tissue of the snail Busycon: polyglucose sulphate.	Polysaccharides	11-25	snail family transcriptional repressor 1	Homo sapiens	53-58
14407781-0	1960	C14-labeled bacterial polysaccharide and lymphosarcoma of the rat.	Polysaccharides	22-36	anti-Mullerian hormone receptor type 2	Rattus norvegicus	0-3
13081612-0	1953	On the polysaccharide of fibrinogen and fibrin.	Polysaccharides	7-21	fibrinogen beta chain	Homo sapiens	25-35
13634128-0	1959	Inactivation by plasma of ACTH-releasing property of C14 labeled bacterial polysaccharides.	Polysaccharides	75-90	proopiomelanocortin	Homo sapiens	26-30
13518990-2	1957	Behavior of total non-glucosaminic polysaccharides and polysaccharides of the mucoproteins of the CSF].	Polysaccharides	35-50	colony stimulating factor 2	Homo sapiens	98-101
14387730-0	1955	The effect of thrombin on the polysaccharide of fibrinogen; a preliminary note.	Polysaccharides	30-44	coagulation factor II, thrombin	Homo sapiens	14-22
14387730-0	1955	The effect of thrombin on the polysaccharide of fibrinogen; a preliminary note.	Polysaccharides	30-44	fibrinogen beta chain	Homo sapiens	48-58
13115403-0	1953	The stabilization of elastin by a polysaccharide.	Polysaccharides	34-48	elastin	Homo sapiens	21-28
13659938-0	1959	[Specific ABO group polysaccharides in saliva in normal subjects and in influenza].	Polysaccharides	20-35	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	10-13
13319582-1	1956	Two distinct R mutants of pneumococcus type VIIIS have been described in which the mutations leading to loss of type VIII polysaccharide production are non-allelic.	Polysaccharides	122-136	cytochrome c oxidase subunit 8A	Homo sapiens	44-48
13128046-0	1953	[Effect of polysaccharides from cancer urine and tissues on liver catalase and arginase].	Polysaccharides	11-26	catalase	Homo sapiens	66-74
14878720-0	1951	[Muscle ferment splitting alpha-1,6 bonds in polysaccharides].	Polysaccharides	45-60	adrenoceptor alpha 1D	Homo sapiens	26-35
13091884-0	1953	[Polysaccharide of fibrinogen and fibrin].	Polysaccharides	1-15	fibrinogen beta chain	Homo sapiens	19-29
14956038-0	1952	Conversion of tissue polysaccharides to auto-antigens by group-A beta-haemolytic streptococci.	Polysaccharides	21-36	amyloid beta precursor protein	Homo sapiens	63-69
13052813-3	1953	In Sab the polysaccharides of types a and b have been demonstrated and in Sad those which characterize types a and d. The Sab and Sad traits are inherited.	Polysaccharides	11-26	SH3 domain binding protein 5	Homo sapiens	3-6
13052813-3	1953	In Sab the polysaccharides of types a and b have been demonstrated and in Sad those which characterize types a and d. The Sab and Sad traits are inherited.	Polysaccharides	11-26	SH3 domain binding protein 5	Homo sapiens	122-125
18867702-0	1948	Bacterial hydrolysis and utilization of polysaccharide-like substances, mucin, in saliva.	Polysaccharides	40-54	LOC100508689	Homo sapiens	72-77
14803629-2	1951	The acute phase protein of the rabbit reacts with a special form of the pneumococcal somatic polysaccharide, designated Cx polysaccharide, in the same manner that the human C-reactive protein reacts with the classical C polysaccharide.	Polysaccharides	93-107	C-reactive protein	Homo sapiens	173-191
14803629-2	1951	The acute phase protein of the rabbit reacts with a special form of the pneumococcal somatic polysaccharide, designated Cx polysaccharide, in the same manner that the human C-reactive protein reacts with the classical C polysaccharide.	Polysaccharides	123-137	C-reactive protein	Homo sapiens	173-191
33620284-2	2021	PIGT encodes phosphatidylinositol-glycan biosynthesis class T, which plays a crucial role in protein anchoring to cell membranes.	Polysaccharides	34-40	phosphatidylinositol glycan anchor biosynthesis class T	Homo sapiens	0-4
20999529-0	1945	[Specific polysaccharides from the bacterium Proteus Ox19, Ox2, and Oxk].	Polysaccharides	10-25	AF4/FMR2 family member 2	Homo sapiens	53-57
20999529-0	1945	[Specific polysaccharides from the bacterium Proteus Ox19, Ox2, and Oxk].	Polysaccharides	10-25	CD200 molecule	Homo sapiens	59-62
33910729-0	2021	Water-soluble polysaccharides from Pleurotus eryngii fruiting bodies, their activity and affinity for Toll-like receptor 2 and dectin-1.	Polysaccharides	14-29	C-type lectin domain containing 7A	Homo sapiens	127-135
33910729-1	2021	The mushroom cell wall contains polysaccharides that can activate cells of the innate immune system through receptors such as Toll-like receptors (TLR) and dectin-1.	Polysaccharides	32-47	C-type lectin domain containing 7A	Homo sapiens	156-164
34053538-3	2021	Herein, we extracted a polysaccharide fraction (GEP) from Gastrodia elata by water extraction and alcohol precipitation and aimed to reveal its oral absorption processes through animal models and Caco-2 cells monolayer models.	Polysaccharides	23-37	granulin precursor	Homo sapiens	48-51
34053538-9	2021	The underlying absorptive mechanisms of GEP in vivo and in vitro were clarified, which provided the guidance for clinical medicine administration and could deepen the biological understanding of oral polysaccharides.	Polysaccharides	200-215	granulin precursor	Homo sapiens	40-43
19871253-2	1942	The specific polysaccharide content of pneumonic lungs in Type III pneumonia was 60 times greater than in Type I, II, VII, and VIII cases.	Polysaccharides	13-27	cytochrome c oxidase subunit 8A	Homo sapiens	127-131
19871166-2	1942	The cross reaction of the specific polysaccharide of Type VIII pneumococcus with Type III antipneumococcus horse serum has been studied quantitatively and found similar to the S III-anti-S VIII reaction.	Polysaccharides	35-49	cytochrome c oxidase subunit 8A	Homo sapiens	58-62
34044950-4	2021	The optimally extracted glucomannan- and glucogalactan-containing polysaccharides revealed significant antidiabetic effects through inhibiting alpha-amylase and alpha-glucosidase, improving dynamic insulin sensitivity and secretion, and promoting pancreatic beta-cell proliferation.	Polysaccharides	66-81	sucrase-isomaltase	Homo sapiens	161-178
34044950-4	2021	The optimally extracted glucomannan- and glucogalactan-containing polysaccharides revealed significant antidiabetic effects through inhibiting alpha-amylase and alpha-glucosidase, improving dynamic insulin sensitivity and secretion, and promoting pancreatic beta-cell proliferation.	Polysaccharides	66-81	insulin	Homo sapiens	198-205
33892066-0	2021	Immunostimulatory effects of the intracellular polysaccharides isolated from liquid culture of Ophiocordyceps sinensis (Ascomycetes) on RAW264.7 cells via the MAPK and P13K/Akt signaling pathways.	Polysaccharides	47-62	thymoma viral proto-oncogene 1	Mus musculus	173-176
33892066-4	2021	AIM OF STUDY: We aimed to investigate composition and structure of the intracellular polysaccharides from O. sinensis mycelia (designed as OSP), and evaluate its the immunomodulatory effect on macrophages and its underlying mechanism.	Polysaccharides	85-100	claudin 11	Mus musculus	139-142
33862459-1	2021	Olfactory receptor 78 (Olfr78), which is also known as a receptor for short-chain fatty acids (SCFAs) produced via gut microbial fermentation from indigestible polysaccharides such as dietary fibers, is expressed in the enteroendocrine cells of the colon.	Polysaccharides	160-175	olfactory receptor family 51 subfamily E member 2	Mus musculus	0-21
33862459-1	2021	Olfactory receptor 78 (Olfr78), which is also known as a receptor for short-chain fatty acids (SCFAs) produced via gut microbial fermentation from indigestible polysaccharides such as dietary fibers, is expressed in the enteroendocrine cells of the colon.	Polysaccharides	160-175	olfactory receptor family 51 subfamily E member 2	Mus musculus	23-29
33758009-9	2021	Solid-phase competition assays showed that the PCSK9 interaction with heparin-albumin (HS-proteoglycan analogue) was critically dependent on polysaccharide chain length.	Polysaccharides	141-155	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	47-52
34043264-4	2021	The glycosylation of exosomal PD-L1 (exoPD-L1) was imaged in situ using intramolecular fluorescence resonance energy transfer (FRET) between fluorescent PD-L1 aptamers bound on exoPD-L1 and fluorescent tags on glycans introduced via metabolic glycan labeling.	Polysaccharides	210-217	CD274 molecule	Homo sapiens	30-35
34019795-3	2021	2G12 is a broadly neutralizing Ab (bnAb) that targets a conserved glycan patch on Env of geographically diverse HIV-1 strains using a unique heavy-chain (VH) domain-swapped architecture that results in fragment antigen-binding (Fab) dimerization.	Polysaccharides	66-72	endogenous retrovirus group K member 20	Homo sapiens	82-85
34019795-4	2021	Here, we describe HIV-1 Env Fab-dimerized glycan (FDG)-reactive bnAbs without VH-swapped domains from simian-human immunodeficiency virus (SHIV)-infected macaques.	Polysaccharides	42-48	endogenous retrovirus group K member 20	Homo sapiens	24-27
34043264-4	2021	The glycosylation of exosomal PD-L1 (exoPD-L1) was imaged in situ using intramolecular fluorescence resonance energy transfer (FRET) between fluorescent PD-L1 aptamers bound on exoPD-L1 and fluorescent tags on glycans introduced via metabolic glycan labeling.	Polysaccharides	210-217	CD274 molecule	Homo sapiens	40-45
34043264-4	2021	The glycosylation of exosomal PD-L1 (exoPD-L1) was imaged in situ using intramolecular fluorescence resonance energy transfer (FRET) between fluorescent PD-L1 aptamers bound on exoPD-L1 and fluorescent tags on glycans introduced via metabolic glycan labeling.	Polysaccharides	210-216	CD274 molecule	Homo sapiens	30-35
34043264-4	2021	The glycosylation of exosomal PD-L1 (exoPD-L1) was imaged in situ using intramolecular fluorescence resonance energy transfer (FRET) between fluorescent PD-L1 aptamers bound on exoPD-L1 and fluorescent tags on glycans introduced via metabolic glycan labeling.	Polysaccharides	210-216	CD274 molecule	Homo sapiens	40-45
33977722-8	2021	Our data revealed that the number of glycan contacts between the Fc and the Fc receptor was increased by the selective core-fucose modifications, showing the importance of unique carbohydrate-carbohydrate interactions in achieving high FcgammaRIIIa affinity and ADCC activity of antibodies.	Polysaccharides	37-43	Fc gamma receptor IIIa	Homo sapiens	236-248
34043154-0	2021	Cytotoxicity and growth-inhibiting activity of Astragalus polysaccharides against breast cancer via the regulation of EGFR and ANXA1.	Polysaccharides	58-73	epidermal growth factor receptor	Homo sapiens	118-122
34043154-0	2021	Cytotoxicity and growth-inhibiting activity of Astragalus polysaccharides against breast cancer via the regulation of EGFR and ANXA1.	Polysaccharides	58-73	annexin A1	Homo sapiens	127-132
34043239-3	2021	Serum transferrin (Tf) glycan isoform analysis by liquid chromatography-mass spectrometry (LC-MS) is used as a primary diagnostic screen tool, and reveals a very unique CDG profile described as a mixture of CDG-type I and CDG-type II patterns.	Polysaccharides	23-29	transferrin	Homo sapiens	6-17
34043239-4	2021	Oral D-galactose supplementation shows significant clinical and metabolic improvements, which are indicated by the Tf glycan isoform normalization over time in patients with PGM1-CDG.	Polysaccharides	118-124	phosphoglucomutase 1	Homo sapiens	174-178
34043239-9	2021	PGM1-TMI allows tracking Tf glycan isoform normalization over time when the patients are on D-galactose supplementation.	Polysaccharides	28-34	phosphoglucomutase 1	Homo sapiens	0-4
33979146-1	2021	The homogeneously glycosylated 76-amino acid adiponectin collagenous domains (ACDs) with all of the possible 15 glycoforms have been chemically and individually synthesized using stereoselective glycan synthesis and chemical peptide ligation.	Polysaccharides	195-201	adiponectin, C1Q and collagen domain containing	Mus musculus	45-56
34004174-4	2021	Comparison of the glycosylation profile of the S protein to that of the HLA-II-bound S peptides reveals substantial trimming of glycan residues on the latter, likely induced during antigen processing.	Polysaccharides	128-134	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	47-48
34004174-4	2021	Comparison of the glycosylation profile of the S protein to that of the HLA-II-bound S peptides reveals substantial trimming of glycan residues on the latter, likely induced during antigen processing.	Polysaccharides	128-134	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	85-86
34044027-4	2021	Two homogeneous polysaccharides (ALP1 and ALP2) were isolated from the fruits.	Polysaccharides	16-31	alkaline phosphatase, germ cell	Homo sapiens	33-37
34018615-1	2021	BACKGROUND: Dark tea, one of the six major teas, has many biological activities, which originates from their active substrates, such as polyphenols, polysaccharide and so on.	Polysaccharides	149-163	dark	Mus musculus	12-16
33908547-0	2021	A polysaccharide of PFP-1 from Pleurotus geesteranus attenuates alcoholic liver diseases via Nrf2 and NF-kappaB signaling pathways.	Polysaccharides	2-16	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-97
34019602-1	2021	We report a distinct difference in the interactions of the glycans of the host-cell receptor, ACE2, with SARS-CoV-2 and SARS-CoV S-protein receptor-binding domains (RBDs).	Polysaccharides	59-66	angiotensin converting enzyme 2	Homo sapiens	94-98
34019602-3	2021	The interactions of the ACE2 glycan at N322 with SARS-CoV RBD are blocked by the presence of the RBD glycan at N357 of the SARS-CoV RBD.	Polysaccharides	29-35	angiotensin converting enzyme 2	Homo sapiens	24-28
34019619-0	2022	Non-Human Glycans Can Regulate Anti-FVIII Antibody Formation in Mice.	Polysaccharides	10-17	coagulation factor VIII	Homo sapiens	36-41
34029582-4	2021	Bioactivity assays implied that the four BPs showed that the polysaccharides (Hw and Na) with higher molecular weight had stronger antioxidant and alpha-glucosidase inhibitory activity.	Polysaccharides	61-76	sucrase-isomaltase	Homo sapiens	147-164
33609441-7	2021	Glycan inhibition induced by Ac5GalNTGc resulted in 50%-80% reduction in leukocyte sialyl-Lewis X expression and L-/P-selectin-mediated rolling under flow conditions.	Polysaccharides	0-6	selectin, platelet	Mus musculus	116-126
33908564-1	2021	Natural sulfated glycans are key players in inflammation through TLR4 activation; therefore synthetic exogenous sulfated saccharides can be used to downregulate inflammation processes.	Polysaccharides	17-24	toll like receptor 4	Homo sapiens	65-69
33272761-4	2021	Patatin had a fucosylated glycan structural feature, which strongly bound AAL (Aleuria aurantia Leukoagglutinin), a known fucose binding lectin.	Polysaccharides	26-32	Patatin class I	Solanum tuberosum	0-7
34002197-0	2021	Microarray investigation of glycan remodeling during macrophage polarization reveals alpha2,6 sialic acid as an anti-inflammatory indicator.	Polysaccharides	28-34	glycoprotein hormone subunit alpha 2	Homo sapiens	85-91
34002390-2	2021	Cress Seed Gum (CSG) with high thermal stability can be a promising polysaccharide to prepare physically cross-linked hydrogel as a curcumin delivery system.	Polysaccharides	68-82	OTU deubiquitinase with linear linkage specificity	Homo sapiens	11-14
34010697-12	2021	In addition, pPMTLs significantly improved expression level of immune-related genes in Inflammation Drosophila especially the defensin (4.32+-0.75 vs 9.97+-0.52 SDS-polysaccharide group: SDS group, p<0.001).	Polysaccharides	165-179	Defensin	Drosophila melanogaster	126-134
34015061-4	2021	DC-SIGN, L-SIGN, Langerin and MGL bind to diverse glycans of the spike using multiple interaction areas.	Polysaccharides	50-57	C-type lectin domain family 4 member M	Homo sapiens	9-15
34015061-4	2021	DC-SIGN, L-SIGN, Langerin and MGL bind to diverse glycans of the spike using multiple interaction areas.	Polysaccharides	50-57	CD207 molecule	Homo sapiens	17-25
34015061-4	2021	DC-SIGN, L-SIGN, Langerin and MGL bind to diverse glycans of the spike using multiple interaction areas.	Polysaccharides	50-57	C-type lectin domain containing 10A	Homo sapiens	30-33
34015061-4	2021	DC-SIGN, L-SIGN, Langerin and MGL bind to diverse glycans of the spike using multiple interaction areas.	Polysaccharides	50-57	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	65-70
33993195-4	2021	Kupffer cells express a C-type lectin receptor, CLEC4F, that recognizes desialylated glycans with an unclear in vivo role in mediating platelet destruction.	Polysaccharides	85-92	C-type lectin domain family 4, member f	Mus musculus	48-54
33662421-0	2021	Purification, structural characterization, and PCSK9 secretion inhibitory effect of the novel alkali-extracted polysaccharide from Cordyceps militaris.	Polysaccharides	111-125	proprotein convertase subtilisin/kexin type 9	Homo sapiens	47-52
33662421-5	2021	This polysaccharide significantly enhanced the intracellular protein expression of low-density lipoprotein receptor and proprotein convertase subtilisin/kexin type 9 (PCSK9) via regulating sterol regulatory element-binding protein 2 in hepatoma Huh7 cells.	Polysaccharides	5-19	low density lipoprotein receptor	Homo sapiens	83-115
33662421-5	2021	This polysaccharide significantly enhanced the intracellular protein expression of low-density lipoprotein receptor and proprotein convertase subtilisin/kexin type 9 (PCSK9) via regulating sterol regulatory element-binding protein 2 in hepatoma Huh7 cells.	Polysaccharides	5-19	proprotein convertase subtilisin/kexin type 9	Homo sapiens	120-165
33662421-5	2021	This polysaccharide significantly enhanced the intracellular protein expression of low-density lipoprotein receptor and proprotein convertase subtilisin/kexin type 9 (PCSK9) via regulating sterol regulatory element-binding protein 2 in hepatoma Huh7 cells.	Polysaccharides	5-19	proprotein convertase subtilisin/kexin type 9	Homo sapiens	167-172
33662421-5	2021	This polysaccharide significantly enhanced the intracellular protein expression of low-density lipoprotein receptor and proprotein convertase subtilisin/kexin type 9 (PCSK9) via regulating sterol regulatory element-binding protein 2 in hepatoma Huh7 cells.	Polysaccharides	5-19	sterol regulatory element binding transcription factor 2	Homo sapiens	189-232
33991349-2	2021	Spike glycan processing and cleavage, which occur in the Golgi network, are important for fusion at the plasma membrane, promoting both virion infectivity and cell-to-cell viral spreading.	Polysaccharides	6-12	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	0-5
34004199-4	2021	By western blotting analysis of CPT-1, PPARgamma and SREBP-1c, those polysaccharides increased lipolysis and decreased lipogenesis in the liver.	Polysaccharides	69-84	carnitine palmitoyltransferase 1b, muscle	Mus musculus	32-37
34004199-4	2021	By western blotting analysis of CPT-1, PPARgamma and SREBP-1c, those polysaccharides increased lipolysis and decreased lipogenesis in the liver.	Polysaccharides	69-84	peroxisome proliferator activated receptor gamma	Mus musculus	39-48
34004199-4	2021	By western blotting analysis of CPT-1, PPARgamma and SREBP-1c, those polysaccharides increased lipolysis and decreased lipogenesis in the liver.	Polysaccharides	69-84	sterol regulatory element binding transcription factor 1	Mus musculus	53-61
33914523-0	2021	Dopant-Enriched Nitrogen Gas for Enhanced Electrospray Ionization of Released Glycans in Negative Ion Mode.	Polysaccharides	78-85	gastrin	Homo sapiens	25-28
33990985-7	2021	This binding interaction is likely glycan-mediated as pre-incubation with galactose, galactosamine, N-acetylgalactosamine and fucose reduced mucin adhesion to control levels.	Polysaccharides	35-41	mucin 1, cell surface associated	Bos taurus	141-146
34013265-8	2021	A local analysis of seven key binding pockets reveals that six out them, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, and protein-glycan interaction sites, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.	Polysaccharides	197-203	angiotensin converting enzyme 2	Homo sapiens	102-106
34013265-8	2021	A local analysis of seven key binding pockets reveals that six out them, including those for engaging ACE2, therapeutic mini-proteins, linoleic acid, two different kinds of antibodies, and protein-glycan interaction sites, switch conformations between their known apo- and holo-conformations, even when the global spike conformation is 1RBD-up.	Polysaccharides	197-203	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	314-319
33986441-9	2021	These findings indicate that there is a complex network of glycan-dependent interactions between mouse IgG3 and the surface of effector immune cells.	Polysaccharides	59-65	Immunoglobulin heavy constant gamma 3	Mus musculus	103-107
33876795-2	2021	Four alpha-1,2-mannosidases-ER mannosidase I, ER degradation-enhancing alpha-mannosidase-like protein 1 (EDEM1), EDEM2, and EDEM3-are involved in the production of these signal glycans.	Polysaccharides	177-184	ER degradation enhancer, mannosidase alpha-like 1	Mus musculus	46-103
33876795-2	2021	Four alpha-1,2-mannosidases-ER mannosidase I, ER degradation-enhancing alpha-mannosidase-like protein 1 (EDEM1), EDEM2, and EDEM3-are involved in the production of these signal glycans.	Polysaccharides	177-184	ER degradation enhancer, mannosidase alpha-like 1	Mus musculus	105-110
33876795-2	2021	Four alpha-1,2-mannosidases-ER mannosidase I, ER degradation-enhancing alpha-mannosidase-like protein 1 (EDEM1), EDEM2, and EDEM3-are involved in the production of these signal glycans.	Polysaccharides	177-184	ER degradation enhancer, mannosidase alpha-like 2	Mus musculus	113-118
33876795-2	2021	Four alpha-1,2-mannosidases-ER mannosidase I, ER degradation-enhancing alpha-mannosidase-like protein 1 (EDEM1), EDEM2, and EDEM3-are involved in the production of these signal glycans.	Polysaccharides	177-184	ER degradation enhancer, mannosidase alpha-like 3	Mus musculus	124-129
34013268-5	2021	Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding.	Polysaccharides	18-24	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	47-48
34013268-5	2021	Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding.	Polysaccharides	18-24	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	58-59
34013268-5	2021	Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding.	Polysaccharides	18-24	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	58-59
33549763-0	2021	Total glycosides and polysaccharides of Cistanche deserticola prevent osteoporosis by activating Wnt/beta-catenin signaling pathway in SAMP6 mice.	Polysaccharides	21-36	catenin (cadherin associated protein), beta 1	Mus musculus	101-113
34013268-5	2021	Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding.	Polysaccharides	98-105	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	47-48
34013268-5	2021	Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding.	Polysaccharides	98-105	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	58-59
34013268-5	2021	Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding.	Polysaccharides	98-105	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	58-59
33903171-5	2021	Interestingly, the glycans at two glycosylation sites, N90 and N322, have opposite effects on spike protein binding.	Polysaccharides	19-26	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	94-99
33903171-7	2021	Therefore, this glycan can interfere with the binding of the spike protein and protect against docking of the virus to the cell.	Polysaccharides	16-22	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	61-66
33903171-8	2021	By contrast, the glycan at the N322 site interacts tightly with the RBD of the ACE2-bound spike protein and strengthens the complex.	Polysaccharides	17-23	angiotensin converting enzyme 2	Homo sapiens	79-83
33903171-8	2021	By contrast, the glycan at the N322 site interacts tightly with the RBD of the ACE2-bound spike protein and strengthens the complex.	Polysaccharides	17-23	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	90-95
33952698-0	2021	Galectin-3 N-terminal tail prolines modulate cell activity and glycan-mediated oligomerization/phase separation.	Polysaccharides	63-69	galectin 3	Homo sapiens	0-10
33952698-9	2021	Molecular- and cell-based assays indicate that glycan binding-triggered Gal-3 LLPS (or LLPS-like) is driven mainly by dynamic intermolecular interactions between the Gal-3 NT and the carbohydrate recognition domain (CRD) F-face, although NT-NT interactions appear to contribute to a lesser extent.	Polysaccharides	47-53	galectin 3	Homo sapiens	72-77
33549763-11	2021	The further mechanisms study showed that TGs and PSs significantly decreased the expressions of RANKL, p-beta-catenin, as well as up-regulated the expression of BMP-2, OCN, OPG, and p-GSK-3beta (Ser9).	Polysaccharides	49-52	catenin (cadherin associated protein), beta 1	Mus musculus	105-117
33549763-12	2021	CONCLUSION: The findings of this study suggest that TGs and PSs can promote osteoblastogenic bone formation and improve bone microstructure damage in SAMP6 mice, and their therapeutic effect on osteoporosis is via activating Wnt/beta-catenin signaling pathway.	Polysaccharides	60-63	catenin (cadherin associated protein), beta 1	Mus musculus	229-241
33592279-0	2021	Gum polysaccharide/nanometal hybrid biocomposites in cancer diagnosis and therapy.	Polysaccharides	4-18	OTU deubiquitinase with linear linkage specificity	Homo sapiens	0-3
33978732-2	2021	Galectin-1, an endogenous lectin with affinity for N-acetyllactosamine (LacNAc)-containing glycans, has emerged as a regulator of inflammatory and metabolic disorders.	Polysaccharides	91-98	lectin, galactose binding, soluble 1	Mus musculus	0-10
33978735-5	2021	The fully N-glycosylated human Gb3/CD77 synthase and its glycoform missing the N121 glycan correctly localized in the Golgi, whereas a glycoform without the N203 site partially mislocalized in the endoplasmic reticulum.	Polysaccharides	84-90	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	31-34
33978735-5	2021	The fully N-glycosylated human Gb3/CD77 synthase and its glycoform missing the N121 glycan correctly localized in the Golgi, whereas a glycoform without the N203 site partially mislocalized in the endoplasmic reticulum.	Polysaccharides	84-90	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	35-48
33978739-6	2021	Our results provide new knowledge on unique glycan-binding specificities for the immune-receptor Dectin-1 towards beta-glucans and the interaction of rotavirus P[19] adhesive protein with mucin O-glycan cores.	Polysaccharides	44-50	C-type lectin domain containing 7A	Homo sapiens	97-105
33978739-6	2021	Our results provide new knowledge on unique glycan-binding specificities for the immune-receptor Dectin-1 towards beta-glucans and the interaction of rotavirus P[19] adhesive protein with mucin O-glycan cores.	Polysaccharides	44-50	LOC100508689	Homo sapiens	188-193
33958792-5	2021	The LiGA is target agnostic and can measure the glycan-binding profile of lectins, such as CD22, on cells in vitro and immune cells in a live mouse.	Polysaccharides	48-54	CD22 antigen	Mus musculus	91-95
33950051-0	2021	Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.	Polysaccharides	0-14	low density lipoprotein receptor	Mus musculus	81-85
33724805-3	2021	Even though the glycan specificity of MGL is known and several binding glycoproteins have been identified, the molecular basis for substrate recognition has remained elusive due to the lack of high-resolution structures.	Polysaccharides	16-22	C-type lectin domain containing 10A	Homo sapiens	38-41
33135055-7	2021	To deduce the detailed structure of glycan epitopes on hACE2 that may be involved in viral binding, we have characterized the terminal sialic acid linkages, the presence of bisecting GlcNAc, and the pattern of N-glycan fucosylation.	Polysaccharides	36-42	angiotensin converting enzyme 2	Homo sapiens	55-60
33852023-11	2021	2-PE synthetic genes ARO8 and ARO9 deletion reduced extracellular polysaccharide.	Polysaccharides	66-80	aromatic-amino-acid:2-oxoglutarate transaminase	Saccharomyces cerevisiae S288C	30-34
33650863-2	2021	Comprehensive glycan profiling of UMOD provides valuable information to understand the exact mechanisms of glycan-regulated functions.	Polysaccharides	14-20	uromodulin	Homo sapiens	34-38
33650863-2	2021	Comprehensive glycan profiling of UMOD provides valuable information to understand the exact mechanisms of glycan-regulated functions.	Polysaccharides	107-113	uromodulin	Homo sapiens	34-38
33650863-5	2021	We found that isolation of UMOD resulted in a significant decrease in the relative quantity of high-mannose and sulfated glycans with a significant increase of neutral fucosylated glycans in the UMOD-depleted urine relative to the undepleted urine, but depletion had little impact on the sialylated glycans.	Polysaccharides	121-128	uromodulin	Homo sapiens	27-31
33650863-5	2021	We found that isolation of UMOD resulted in a significant decrease in the relative quantity of high-mannose and sulfated glycans with a significant increase of neutral fucosylated glycans in the UMOD-depleted urine relative to the undepleted urine, but depletion had little impact on the sialylated glycans.	Polysaccharides	180-187	uromodulin	Homo sapiens	27-31
33650863-5	2021	We found that isolation of UMOD resulted in a significant decrease in the relative quantity of high-mannose and sulfated glycans with a significant increase of neutral fucosylated glycans in the UMOD-depleted urine relative to the undepleted urine, but depletion had little impact on the sialylated glycans.	Polysaccharides	180-187	uromodulin	Homo sapiens	195-199
33650863-5	2021	We found that isolation of UMOD resulted in a significant decrease in the relative quantity of high-mannose and sulfated glycans with a significant increase of neutral fucosylated glycans in the UMOD-depleted urine relative to the undepleted urine, but depletion had little impact on the sialylated glycans.	Polysaccharides	180-187	uromodulin	Homo sapiens	27-31
33650863-5	2021	We found that isolation of UMOD resulted in a significant decrease in the relative quantity of high-mannose and sulfated glycans with a significant increase of neutral fucosylated glycans in the UMOD-depleted urine relative to the undepleted urine, but depletion had little impact on the sialylated glycans.	Polysaccharides	180-187	uromodulin	Homo sapiens	195-199
33965492-6	2021	APS-4II was a novel polysaccharide with molecular weight of 11.1 kDa, which consisted of 55.4% alpha-1,6-Glcp, 10.4% alpha-1,3,5-Araf, 8.7% alpha-T-Araf, 9.2% alpha-1,5-Araf, 4.0% alpha-1,3-Araf, 3.6% alpha-1,4-Galp, and 9.1% beta-1,3-Galp.	Polysaccharides	20-34	Araf proto-oncogene, serine/threonine kinase	Mus musculus	129-133
33965492-6	2021	APS-4II was a novel polysaccharide with molecular weight of 11.1 kDa, which consisted of 55.4% alpha-1,6-Glcp, 10.4% alpha-1,3,5-Araf, 8.7% alpha-T-Araf, 9.2% alpha-1,5-Araf, 4.0% alpha-1,3-Araf, 3.6% alpha-1,4-Galp, and 9.1% beta-1,3-Galp.	Polysaccharides	20-34	Araf proto-oncogene, serine/threonine kinase	Mus musculus	148-152
33965492-6	2021	APS-4II was a novel polysaccharide with molecular weight of 11.1 kDa, which consisted of 55.4% alpha-1,6-Glcp, 10.4% alpha-1,3,5-Araf, 8.7% alpha-T-Araf, 9.2% alpha-1,5-Araf, 4.0% alpha-1,3-Araf, 3.6% alpha-1,4-Galp, and 9.1% beta-1,3-Galp.	Polysaccharides	20-34	Araf proto-oncogene, serine/threonine kinase	Mus musculus	148-152
33965492-6	2021	APS-4II was a novel polysaccharide with molecular weight of 11.1 kDa, which consisted of 55.4% alpha-1,6-Glcp, 10.4% alpha-1,3,5-Araf, 8.7% alpha-T-Araf, 9.2% alpha-1,5-Araf, 4.0% alpha-1,3-Araf, 3.6% alpha-1,4-Galp, and 9.1% beta-1,3-Galp.	Polysaccharides	20-34	Araf proto-oncogene, serine/threonine kinase	Mus musculus	148-152
33965492-6	2021	APS-4II was a novel polysaccharide with molecular weight of 11.1 kDa, which consisted of 55.4% alpha-1,6-Glcp, 10.4% alpha-1,3,5-Araf, 8.7% alpha-T-Araf, 9.2% alpha-1,5-Araf, 4.0% alpha-1,3-Araf, 3.6% alpha-1,4-Galp, and 9.1% beta-1,3-Galp.	Polysaccharides	20-34	galanin-like peptide	Mus musculus	211-215
33965492-6	2021	APS-4II was a novel polysaccharide with molecular weight of 11.1 kDa, which consisted of 55.4% alpha-1,6-Glcp, 10.4% alpha-1,3,5-Araf, 8.7% alpha-T-Araf, 9.2% alpha-1,5-Araf, 4.0% alpha-1,3-Araf, 3.6% alpha-1,4-Galp, and 9.1% beta-1,3-Galp.	Polysaccharides	20-34	galanin-like peptide	Mus musculus	235-239
33592279-1	2021	Biopolymers are of prime importance among which gum polysaccharides hold an eminent standing owing to their high availability and non-toxic nature.	Polysaccharides	52-67	OTU deubiquitinase with linear linkage specificity	Homo sapiens	48-51
34036206-0	2021	Lytic transglycosylase MltG cleaves in nascent peptidoglycan and produces short glycan strands.	Polysaccharides	54-60	endolytic transglycosylase MltG	Bacillus subtilis	23-27
34036206-5	2021	Using in vitro PG synthesis assays with radio-labelled or fluorophore-labelled B. subtilis-type and/or E. coli-type lipid II, we showed that both, BsMltG and EcMltG, are lytic tranglycosylases and that their activity is higher during ongoing glycan strand polymerisation.	Polysaccharides	242-248	endolytic transglycosylase MltG	Bacillus subtilis	147-153
34036206-7	2021	We hypothesize that MltG cleaves the nascent strands to produce short glycan strands that are used in the cell for a yet unknown process.	Polysaccharides	70-76	endolytic transglycosylase MltG	Bacillus subtilis	20-24
34036206-6	2021	MltG competed with the transpeptidase activity of class A PBPs, but had no effect on their glycosyltransferase activity, and produced glycan strands with a length of 7 disaccharide units from cleavage in the nascent strands.	Polysaccharides	134-140	endolytic transglycosylase MltG	Bacillus subtilis	0-4
33592405-5	2021	We wished to investigate the immunoregulatory activities of the selenized polysaccharides of lily bulb (sLP).	Polysaccharides	74-89	superkiller viralicidic activity 2-like (S. cerevisiae), pseudogene 1	Mus musculus	104-107
33268179-2	2021	We prepared the polysaccharide fraction of radish greens (PRG) and assessed its anti-obesity activity in high fat diet (HFD)-induced obese C57BL/6J mice.	Polysaccharides	16-30	serglycin	Mus musculus	58-61
33706067-4	2021	The virus may, by mimicking the synthetic pathways of the ABO(H) blood groups, bind to the cell surfaces of the blood group O(H) by formation of a hybrid H-type antigen as the potential precursor of hybrid non-O blood groups, which does not affect the highly anti-glycan aggressive anti-A and anti-B isoagglutinin activities, exerted by the germline-encoded nonimmune immunoglobulin M (IgM).	Polysaccharides	264-270	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	58-61
33529763-4	2021	Currently, preparation of recombinant gp120 with native glycans relies solely on transient expression systems, which are not amendable for large scale production.	Polysaccharides	56-63	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	38-43
33788378-5	2021	It was shown that removal of glycans decreased the binding between UMOD and cFH and abolished the ability of enhancing C3b degradation.	Polysaccharides	29-36	uromodulin	Homo sapiens	67-71
33788378-5	2021	It was shown that removal of glycans decreased the binding between UMOD and cFH and abolished the ability of enhancing C3b degradation.	Polysaccharides	29-36	complement factor H	Homo sapiens	76-79
33788378-5	2021	It was shown that removal of glycans decreased the binding between UMOD and cFH and abolished the ability of enhancing C3b degradation.	Polysaccharides	29-36	complement C3	Homo sapiens	119-122
33470775-8	2021	An increased opsonization index was found in the sera after vaccination for all IRAK-deficient patients, including when the 23-valent pneumococcal polysaccharide vaccine was used.	Polysaccharides	147-161	interleukin 1 receptor associated kinase 1	Homo sapiens	80-84
33692650-5	2021	The presence of heterogeneous glycan chains on neutrophil elastase and the structural heterogeneity of heparin oligomers render the use of standard MS to study their complexes impractical.	Polysaccharides	30-36	elastase, neutrophil expressed	Homo sapiens	47-66
33205457-7	2021	RESULTS: The results showed that the composite particles comprising two polysaccharides in a mass ratio of 1:1 and at a pH of 2 (ChN1 -F1 -pH2) possessed the lowest sulfate content (20.1%) and almost zero potential (-3 mV), indicating the high degree of neutralization of the positively charged amino group in ChN and the negatively charged sulfate group in F. Meanwhile, ChN1 -F1 -pH2 displayed a dense network structure that improved the dispersibility and wettability (contact angle = 9.3 ).	Polysaccharides	72-87	chimerin 1	Homo sapiens	129-133
33205457-7	2021	RESULTS: The results showed that the composite particles comprising two polysaccharides in a mass ratio of 1:1 and at a pH of 2 (ChN1 -F1 -pH2) possessed the lowest sulfate content (20.1%) and almost zero potential (-3 mV), indicating the high degree of neutralization of the positively charged amino group in ChN and the negatively charged sulfate group in F. Meanwhile, ChN1 -F1 -pH2 displayed a dense network structure that improved the dispersibility and wettability (contact angle = 9.3 ).	Polysaccharides	72-87	chimerin 1	Homo sapiens	372-376
33743201-12	2021	Severe infections (p=0 0007), bacterial infections (p=0 0005), and infections with polysaccharide encapsulated bacteria (p=0 0005) that share immunological properties with blood group antigens occurred less frequently after ABO-incompatible heart transplantation.	Polysaccharides	83-97	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	224-227
33947960-3	2021	However, the site-specific glycan repertoire of ErbB2, as well as the detailed molecular mechanisms through which specific aberrant glycan signatures functionally impact the malignant features of ErbB2-addicted GC cells, including the acquisition of trastuzumab resistance, remain elusive.	Polysaccharides	132-138	erb-b2 receptor tyrosine kinase 2	Homo sapiens	196-201
33947960-4	2021	Here, we demonstrate that ErbB2 is modified with both alpha2,6- and alpha2,3-sialylated glycan structures in GC clinical specimens.	Polysaccharides	88-94	erb-b2 receptor tyrosine kinase 2	Homo sapiens	26-31
33734311-0	2021	Appropriate aglycone modification significantly expands the glycan substrate acceptability of alpha1,6-fucosyltransferase (FUT8).	Polysaccharides	60-66	fucosyltransferase 8	Homo sapiens	94-121
33666221-6	2021	The utilization of several plant dietary oligosaccharides has been studied in detail, and the prime importance of oligosaccharide-specific ATP-binding cassette (ABC) transporters in glycan utilisations by bifidobacteria has been revealed.	Polysaccharides	182-188	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	139-159
33734311-0	2021	Appropriate aglycone modification significantly expands the glycan substrate acceptability of alpha1,6-fucosyltransferase (FUT8).	Polysaccharides	60-66	fucosyltransferase 8	Homo sapiens	123-127
33666221-6	2021	The utilization of several plant dietary oligosaccharides has been studied in detail, and the prime importance of oligosaccharide-specific ATP-binding cassette (ABC) transporters in glycan utilisations by bifidobacteria has been revealed.	Polysaccharides	182-188	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	161-164
34056092-6	2021	To test this hypothesis, we developed synthetic mucin mimics that recapitulate the dense display of glycans and morphology of mucin.	Polysaccharides	100-107	LOC100508689	Homo sapiens	48-53
33593560-1	2021	Gum karaya is a polysaccharide that has several industrial applications in the pharmaceutical, food, and environmental fields owing to its hydrophilic, anionic, and biocompatible nature.	Polysaccharides	16-30	OTU deubiquitinase with linear linkage specificity	Homo sapiens	0-3
33924774-6	2021	In our study, tandem mass spectrometry analysis of recombinant ANTXR1-Fc revealed the presence of complex glycans at N166, N184 in the vWA domain, and N81 in the Fc domain.	Polysaccharides	106-113	ANTXR cell adhesion molecule 1	Homo sapiens	63-69
33893702-3	2021	POMGNT2 is a glycosyltransferase which adds beta1,4-linked GlcNAc to the O-mannose (Man) residue to acquire core M3-type glycan.	Polysaccharides	121-127	protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)	Homo sapiens	0-7
33879638-8	2021	qRT-PCR analysis revealed that expression levels of phosphoglucose isomerase (PGI) and UDP-Glc 4-epimerase (UGE), two key genes involved in polysaccharide synthesis, varied depending on carbon source.	Polysaccharides	140-154	glucose-6-phosphate isomerase 1	Mus musculus	52-76
33879638-8	2021	qRT-PCR analysis revealed that expression levels of phosphoglucose isomerase (PGI) and UDP-Glc 4-epimerase (UGE), two key genes involved in polysaccharide synthesis, varied depending on carbon source.	Polysaccharides	140-154	glucose-6-phosphate isomerase 1	Mus musculus	78-81
33883138-5	2021	The increased glycan complexity in the LDKO correlated well with dilated unstacked Golgi ribbons and alterations in the secretion of albumin, cholesterol, and triglycerides.	Polysaccharides	14-20	albumin	Homo sapiens	133-140
33879590-14	2021	SpA of S. aureus carries a LysM domain that binds glycan strands of peptidoglycan to influence defined B cell responses that divert pathogen-specific adaptive immune responses.	Polysaccharides	50-56	surfactant associated protein A1	Mus musculus	0-3
33879788-4	2021	Combining transcriptomic and glycomic analysis, we show that transformation of fibroblasts into pro-inflammatory cells is associated with glycan remodeling, a process that involves TNF-dependent inhibition of the glycosyltransferase ST6Gal1 and alpha2-6 sialylation.	Polysaccharides	138-144	tumor necrosis factor	Homo sapiens	181-184
33879788-4	2021	Combining transcriptomic and glycomic analysis, we show that transformation of fibroblasts into pro-inflammatory cells is associated with glycan remodeling, a process that involves TNF-dependent inhibition of the glycosyltransferase ST6Gal1 and alpha2-6 sialylation.	Polysaccharides	138-144	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	245-253
33875938-12	2021	Further analysis revealed that the mRNA and protein expression of caspase-3, caspase-8, and caspase-9 in the A. paniculata polysaccharide treatment groups increased significantly compared with that in the control groups, while the expression of CDK1 and cyclinB1 decreased significantly.	Polysaccharides	123-137	caspase 3	Homo sapiens	66-75
33875938-12	2021	Further analysis revealed that the mRNA and protein expression of caspase-3, caspase-8, and caspase-9 in the A. paniculata polysaccharide treatment groups increased significantly compared with that in the control groups, while the expression of CDK1 and cyclinB1 decreased significantly.	Polysaccharides	123-137	caspase 8	Homo sapiens	77-86
33875938-12	2021	Further analysis revealed that the mRNA and protein expression of caspase-3, caspase-8, and caspase-9 in the A. paniculata polysaccharide treatment groups increased significantly compared with that in the control groups, while the expression of CDK1 and cyclinB1 decreased significantly.	Polysaccharides	123-137	caspase 9	Homo sapiens	92-101
33875938-12	2021	Further analysis revealed that the mRNA and protein expression of caspase-3, caspase-8, and caspase-9 in the A. paniculata polysaccharide treatment groups increased significantly compared with that in the control groups, while the expression of CDK1 and cyclinB1 decreased significantly.	Polysaccharides	123-137	cyclin dependent kinase 1	Homo sapiens	245-249
33875938-12	2021	Further analysis revealed that the mRNA and protein expression of caspase-3, caspase-8, and caspase-9 in the A. paniculata polysaccharide treatment groups increased significantly compared with that in the control groups, while the expression of CDK1 and cyclinB1 decreased significantly.	Polysaccharides	123-137	cyclin B1	Homo sapiens	254-262
33378651-4	2021	Furthermore, comparative analysis of GBP-coding genes in resident and elicited macrophages indicated that GBP expression is consistent with specialized macrophage functions and correlates with specific types of displayed glycans.	Polysaccharides	221-228	lectin, galactose binding, soluble 3	Mus musculus	37-40
33378651-4	2021	Furthermore, comparative analysis of GBP-coding genes in resident and elicited macrophages indicated that GBP expression is consistent with specialized macrophage functions and correlates with specific types of displayed glycans.	Polysaccharides	221-228	lectin, galactose binding, soluble 3	Mus musculus	106-109
33962190-2	2021	Multivalent presentation of glycans was shown to strongly increase the affinity of glycoconjugates to galectin-3.	Polysaccharides	28-35	galectin 3	Homo sapiens	102-112
33962190-8	2021	Coupling to human serum albumin afforded multivalent neo-glycoproteins with up to 4209-fold increased inhibitory potency per glycan compared to the monovalent lactose standard.	Polysaccharides	125-131	albumin	Homo sapiens	18-31
33895177-1	2021	Size controllable silver nanoparticles (AgNPs) were synthesized in situ on the polysaccharides-based nanotubes, which were formed by the triple-helix polysaccharide extracted from black fungus (AF1).	Polysaccharides	79-94	ephrin A5	Homo sapiens	194-197
33895177-1	2021	Size controllable silver nanoparticles (AgNPs) were synthesized in situ on the polysaccharides-based nanotubes, which were formed by the triple-helix polysaccharide extracted from black fungus (AF1).	Polysaccharides	79-93	ephrin A5	Homo sapiens	194-197
33872211-2	2021	The best current correlates of protection against cholera target Vibrio cholerae O-specific polysaccharide (anti-OSP), including vibriocidal responses.	Polysaccharides	92-106	claudin 11	Mus musculus	113-116
33862080-6	2021	The combined therapeutic efficacy of mucilage polysaccharides, biodegradable nanoscaled cobalt and bio-polymer enhanced the pro-angiogenic capability of the hydrocolloids by stimulating Vascular Endothelial Growth Factor (VEGF) response at wounded tissue for faster healing.	Polysaccharides	46-61	vascular endothelial growth factor A	Gallus gallus	186-220
33862080-6	2021	The combined therapeutic efficacy of mucilage polysaccharides, biodegradable nanoscaled cobalt and bio-polymer enhanced the pro-angiogenic capability of the hydrocolloids by stimulating Vascular Endothelial Growth Factor (VEGF) response at wounded tissue for faster healing.	Polysaccharides	46-61	vascular endothelial growth factor A	Gallus gallus	222-226
33861503-1	2021	In the present study, a novel cold water-soluble polysaccharide fraction (LGP) with the average molecular weight of 1.78x10 6 Da was extracted and purified from Leucopaxillus giganteus and its primary structure as well as in vivo antitumor activity was evaluated.	Polysaccharides	49-63	secretoglobin, family 1B, member 2	Mus musculus	74-77
33238000-2	2021	Sialylated derivatives of the glycan structure beta4-N-acetyllactosamine (Galbeta1,4GlcNAc or type-2 LacNAc, thereafter referred to as LacNAc) regulate platelet lifespan, hepatic Thrombopoietin production, and thrombopoiesis.	Polysaccharides	30-36	thrombopoietin	Homo sapiens	179-193
33858135-0	2021	Mechanism of Glycans Modulating Cholesteryl Ester Transfer Protein: Unveiled by Molecular Dynamics Simulation.	Polysaccharides	13-20	cholesteryl ester transfer protein	Homo sapiens	32-66
33858135-4	2021	In this work, large-scale molecular dynamics simulations were performed to thoroughly explore the mechanism of glycans modulating CETP.	Polysaccharides	111-118	cholesteryl ester transfer protein	Homo sapiens	130-134
33852862-1	2021	Antibodies that target the glycan cap epitope on the ebolavirus glycoprotein (GP) are common in the adaptive response of survivors.	Polysaccharides	27-33	ring finger protein 130	Homo sapiens	64-76
33921025-1	2021	Polysaccharides such as beta-2,1-linked fructans including inulin or fructose oligosaccharides are well-known prebiotics with recognised immunomodulatory properties.	Polysaccharides	0-15	ATPase H+ transporting V0 subunit a2	Homo sapiens	24-30
33852862-1	2021	Antibodies that target the glycan cap epitope on the ebolavirus glycoprotein (GP) are common in the adaptive response of survivors.	Polysaccharides	27-33	ring finger protein 130	Homo sapiens	78-80
33852862-3	2021	Here, we present cryoelectron microscopy (cryo-EM) structures of diverse glycan cap antibodies that variably synergize with GP base-binding antibodies.	Polysaccharides	73-79	ring finger protein 130	Homo sapiens	124-126
33689337-3	2021	In this work, multiple mus-long all-atom molecular dynamics simulations were performed to provide deeper insights into the structure and dynamics of S protein and glycan functions.	Polysaccharides	163-169	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	149-150
33928117-0	2021	Glycans of SARS-CoV-2 Spike Protein in Virus Infection and Antibody Production.	Polysaccharides	0-7	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	22-27
33836197-4	2021	Furthermore, Fourier transform infrared spectrometry, methylation analysis and nuclear magnetic resonance spectroscopy suggested that the main polysaccharide ALP-1 had a linear chain of (1   2)-linked beta-D-Fructofuranosyl backbone (n   15) linked to a terminal (1   2)-linked alpha-d-Glucopyranosyl at the non-reducing end.	Polysaccharides	143-157	alkaline phosphatase, germ cell	Homo sapiens	158-163
33826885-1	2021	Artificial glycan holes on recombinant Env-based vaccines occur when a potential N-linked glycosylation site (PNGS) is under-occupied, but not on their viral counterparts.	Polysaccharides	11-17	endogenous retrovirus group K member 20	Homo sapiens	39-42
33704312-2	2021	By employing an HS microarray and SPR, we deciphered the crucial structure-binding relationship of these glycans with the growth factors BMP2, VEGF165, HB-EGF, and FGF2.	Polysaccharides	105-112	sepiapterin reductase	Homo sapiens	34-37
33704312-2	2021	By employing an HS microarray and SPR, we deciphered the crucial structure-binding relationship of these glycans with the growth factors BMP2, VEGF165, HB-EGF, and FGF2.	Polysaccharides	105-112	bone morphogenetic protein 2	Homo sapiens	137-141
33704312-2	2021	By employing an HS microarray and SPR, we deciphered the crucial structure-binding relationship of these glycans with the growth factors BMP2, VEGF165, HB-EGF, and FGF2.	Polysaccharides	105-112	heparin binding EGF like growth factor	Homo sapiens	152-158
33704312-2	2021	By employing an HS microarray and SPR, we deciphered the crucial structure-binding relationship of these glycans with the growth factors BMP2, VEGF165, HB-EGF, and FGF2.	Polysaccharides	105-112	fibroblast growth factor 2	Homo sapiens	164-168
33829312-1	2021	Chitosan is a very well-known biocompatible and biodegradable polysaccharide consisting of beta-(1-4)-linked glucosamine units, derived from the deacetylation of chitin.	Polysaccharides	62-76	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	91-100
33836197-5	2021	All five polysaccharides displayed high antioxidant ability, especially ALP-4 in H2O2-induced HepG2 cell model and ALP-1 in metronidazole [MET]-induced zebrafish model.	Polysaccharides	9-24	alkaline phosphatase, germ cell	Homo sapiens	115-120
33836197-5	2021	All five polysaccharides displayed high antioxidant ability, especially ALP-4 in H2O2-induced HepG2 cell model and ALP-1 in metronidazole [MET]-induced zebrafish model.	Polysaccharides	9-24	SAFB like transcription modulator	Homo sapiens	139-142
33527486-8	2021	Here, interaction of ANL with AFP could be effectively blocked in the presence of competing fucose-bearing glycans.	Polysaccharides	107-114	alpha fetoprotein	Homo sapiens	30-33
33927974-4	2021	In this study, enzyme immobilization of glucose oxidase (GOx) on filter paper were examined using three polysaccharides such as chitosan, sodium alginate and dextran for entrapment efficiency, activity and stability of the immobilized enzyme.	Polysaccharides	104-119	hydroxyacid oxidase 1	Homo sapiens	40-55
33927974-4	2021	In this study, enzyme immobilization of glucose oxidase (GOx) on filter paper were examined using three polysaccharides such as chitosan, sodium alginate and dextran for entrapment efficiency, activity and stability of the immobilized enzyme.	Polysaccharides	104-119	hydroxyacid oxidase 1	Homo sapiens	57-60
33823775-8	2021	Apart from them, natural bioactive ingredients from plants, such as flavonoids, polyphenols, alkaloids, terpenoids, polysaccharides, and quinones are efficient in helping weight loss and improving insulin sensitivity and glycemic control.	Polysaccharides	116-131	insulin	Homo sapiens	197-204
32865877-0	2021	TLR-MyD88-signaling blockades inhibit refractory B-1b cell immune responses to transplant-related glycan antigens.	Polysaccharides	98-104	myeloid differentiation primary response gene 88	Mus musculus	4-9
32865877-6	2021	Thus, this study provides a rationale for a novel therapeutic approach to overcome refractory transplant-related anti-glycan Ab production by blocking both BCR and TLRs-MyD88 signals.	Polysaccharides	118-124	myeloid differentiation primary response gene 88	Mus musculus	169-174
33713911-0	2021	Glycan structure-based perspectives on the entry and release of glycoproteins in the calnexin/calreticulin cycle.	Polysaccharides	0-6	calnexin	Homo sapiens	85-93
33713911-0	2021	Glycan structure-based perspectives on the entry and release of glycoproteins in the calnexin/calreticulin cycle.	Polysaccharides	0-6	calreticulin	Homo sapiens	94-106
32909036-8	2021	Overall, our study provides structural details for a new type of galectin-sugar interaction that broadens glycospace for ligand binding to Gal-3 and suggests how the lectin may recognize other negatively charged polysaccharides like glycoaminoglycans (e.g. heparan sulfate) on the cell surface.	Polysaccharides	212-227	galectin 3	Homo sapiens	139-144
32651954-1	2021	Glucuronyl C5-epimerase (Hsepi) is a key enzyme in the biosynthesis of heparan sulfate that is a sulfated polysaccharide expressed on the cell surface and in the extracellular matrix of alveolar walls and blood vessels.	Polysaccharides	106-120	glucuronyl C5-epimerase	Mus musculus	0-23
32651954-1	2021	Glucuronyl C5-epimerase (Hsepi) is a key enzyme in the biosynthesis of heparan sulfate that is a sulfated polysaccharide expressed on the cell surface and in the extracellular matrix of alveolar walls and blood vessels.	Polysaccharides	106-120	glucuronyl C5-epimerase	Mus musculus	25-30
33861898-6	2021	Using this method, the capture and study of glycan-GBP interactions no longer relies on weak, transient interactions, and results in robust capture and identification of the interactome of a GBP while preserving the native cellular environment.	Polysaccharides	44-50	galectin 1	Homo sapiens	51-54
33861898-6	2021	Using this method, the capture and study of glycan-GBP interactions no longer relies on weak, transient interactions, and results in robust capture and identification of the interactome of a GBP while preserving the native cellular environment.	Polysaccharides	44-50	galectin 1	Homo sapiens	191-194
32776095-5	2021	MMP10, the principal gene upregulated when cells carrying sialylated core 1 glycans were stimulated with EGF, is also upregulated in ER positive breast carcinoma reported to express high levels of ST3Gal1 and hence mainly core 1 sialylated O-glycans.	Polysaccharides	76-83	matrix metallopeptidase 10	Homo sapiens	0-5
32776095-5	2021	MMP10, the principal gene upregulated when cells carrying sialylated core 1 glycans were stimulated with EGF, is also upregulated in ER positive breast carcinoma reported to express high levels of ST3Gal1 and hence mainly core 1 sialylated O-glycans.	Polysaccharides	76-83	epidermal growth factor	Homo sapiens	105-108
32776095-6	2021	In contrast, isogenic cells engineered to carry core 2 glycans upregulate CX3CL1 and FGFBP1 and these genes are upregulated in ER negative breast carcinomas, also known to express longer core 2 O-glycans.	Polysaccharides	55-62	C-X3-C motif chemokine ligand 1	Homo sapiens	74-80
32776095-6	2021	In contrast, isogenic cells engineered to carry core 2 glycans upregulate CX3CL1 and FGFBP1 and these genes are upregulated in ER negative breast carcinomas, also known to express longer core 2 O-glycans.	Polysaccharides	55-62	fibroblast growth factor binding protein 1	Homo sapiens	85-91
33644825-8	2021	The increased heterogeneity of serum N-glycome in the studied patients suggests a marginal disarrangement of the glycan processing in ALG2-CDG.	Polysaccharides	113-119	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	134-138
32909036-3	2021	Here, we used crystallography and NMR spectroscopy to demonstrate that negatively charged homogalacturonans (HG, linear polysaccharides of alpha(1 4)-linked-D-galacturonate (GalA)) bind to the galectin-3 carbohydrate recognition domain.	Polysaccharides	120-135	galactosidase alpha	Homo sapiens	174-178
32909036-3	2021	Here, we used crystallography and NMR spectroscopy to demonstrate that negatively charged homogalacturonans (HG, linear polysaccharides of alpha(1 4)-linked-D-galacturonate (GalA)) bind to the galectin-3 carbohydrate recognition domain.	Polysaccharides	120-135	galectin 3	Homo sapiens	193-203
33459939-1	2021	Sialic acids occur ubiquitously throughout vertebrate glycomes and often endcap glycans in either alpha2,3- or alpha2,6-linkage with diverse biological roles.	Polysaccharides	80-87	immunoglobulin kappa variable 2-24	Homo sapiens	98-107
33444859-6	2021	For the purple module negatively correlated with ASPF, we identified 19 hub genes that were involved in the biological processes of positive regulation of cellular protein catabolic process and KEGG pathways of other glycan degradation.	Polysaccharides	217-223	ELAV like RNA binding protein 2	Homo sapiens	72-75
33605822-11	2021	Elucidation of the glycan repertoire on the spike protein can propel research for the development of an appropriate vaccine.	Polysaccharides	19-25	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	44-49
33551170-7	2021	Overall, approximately 60% of the N-glycan pool in milk protein was sialylated, or fucosylated, or both; GlyCAM-1 contributed approximately 78% of the total number of glycans in the overall whey protein N-linked glycan pool.	Polysaccharides	167-174	glycosylation dependent cell adhesion molecule 1	Bos taurus	105-113
33551170-8	2021	The degree of fucosylation ranged from 44.8 to 73.3% between cows, and this variation was mainly attributed to the glycans of GlyCAM-1.	Polysaccharides	115-122	glycosylation dependent cell adhesion molecule 1	Bos taurus	126-134
33205491-2	2021	Polysaccharides of RB (RBP) were prepared and well-characterized using chemical analyses.	Polysaccharides	0-15	retinol binding protein 4, plasma	Mus musculus	23-26
33539960-4	2021	The results showed that the snail mucus was mainly composed of proteins and polysaccharides, and it had good adhesion.	Polysaccharides	76-91	snail family zinc finger 1	Mus musculus	28-33
32791164-8	2021	The affinity of Siglec-8 binding to purified human airway ligand was determined by glycan binding inhibition.	Polysaccharides	83-89	sialic acid binding Ig like lectin 8	Homo sapiens	16-24
33849842-4	2021	The effects of polysaccharides in improving insulin sensitivity and regulating glucose and lipid metabolism have drawn much attention from researchers.	Polysaccharides	15-30	insulin	Homo sapiens	44-51
33849842-5	2021	Many polysaccharides can reduce blood glucose and blood lipid by repairing pancreatic islet cells, improving insulin resistance, regulating intestinal flora, enhancing antioxidant capacity, and regulating the activities of key enzymes in glucose and lipid metabolism.	Polysaccharides	5-20	insulin	Homo sapiens	109-116
33849842-7	2021	The mechanisms of polysaccharide in regulating glucose metabolism include repairing islet cells and increasing insulin content, increasing insulin sensitivity and improving insulin resistance, regulating the activity of key enzymes in glucose metabolism, increasing synthesis of liver glycogen, and regulating intestinal flora.	Polysaccharides	18-32	insulin	Homo sapiens	111-118
33849842-7	2021	The mechanisms of polysaccharide in regulating glucose metabolism include repairing islet cells and increasing insulin content, increasing insulin sensitivity and improving insulin resistance, regulating the activity of key enzymes in glucose metabolism, increasing synthesis of liver glycogen, and regulating intestinal flora.	Polysaccharides	18-32	insulin	Homo sapiens	139-146
33849842-7	2021	The mechanisms of polysaccharide in regulating glucose metabolism include repairing islet cells and increasing insulin content, increasing insulin sensitivity and improving insulin resistance, regulating the activity of key enzymes in glucose metabolism, increasing synthesis of liver glycogen, and regulating intestinal flora.	Polysaccharides	18-32	insulin	Homo sapiens	139-146
33849842-9	2021	Polysaccharide also regulate lipid metabolism by regulating lipid absorption, expression of the related genes such as PPAR-alpha, enzyme activities in lipid metabolism, improving antioxidant capacity, and modulating intestinal flora and signaling pathways.	Polysaccharides	0-14	peroxisome proliferator activated receptor alpha	Homo sapiens	118-128
33842774-2	2021	beta-Lactoglobulin (BLG), the dominant whey protein in bovine milk, is well known to bind small molecules such as fatty acids, vitamins, and flavors, and to interact with neutral and anionic polysaccharides used in food and pharmaceuticals.	Polysaccharides	191-206	beta-lactoglobulin	Bos taurus	0-18
33035857-0	2021	Structural characterization, alpha-amylase and alpha-glucosidase inhibitory activities of polysaccharides from wheat bran.	Polysaccharides	90-105	sucrase-isomaltase	Homo sapiens	47-64
33035857-1	2021	In this study, two polysaccharide fractions were isolated from wheat bran by sequential extraction with water and alkaline solution, DEAE Cellulose-52 chromatography and Sephacryl S-400 gel permeation chromatography, they were named as WXA-1 and AXA-1, respectively.	Polysaccharides	19-33	aprataxin	Homo sapiens	246-251
33842774-2	2021	beta-Lactoglobulin (BLG), the dominant whey protein in bovine milk, is well known to bind small molecules such as fatty acids, vitamins, and flavors, and to interact with neutral and anionic polysaccharides used in food and pharmaceuticals.	Polysaccharides	191-206	beta-lactoglobulin	Bos taurus	20-23
33750987-3	2021	Anti-glycan antibodies, such as 2G12, target the HIV-1 envelope protein (Env), which is even more extensively glycosylated and contains under-processed oligomannose-type clusters on its dense glycan shield.	Polysaccharides	5-11	endogenous retrovirus group K member 6, envelope	Homo sapiens	55-71
33829001-0	2021	Plasmid-Chromosome Crosstalk in Staphylococcus aureus: A Horizontally Acquired Transcription Regulator Controls Polysaccharide Intercellular Adhesin-Mediated Biofilm Formation.	Polysaccharides	112-126	AT695_RS03940	Staphylococcus aureus	141-148
33750987-3	2021	Anti-glycan antibodies, such as 2G12, target the HIV-1 envelope protein (Env), which is even more extensively glycosylated and contains under-processed oligomannose-type clusters on its dense glycan shield.	Polysaccharides	5-11	endogenous retrovirus group K member 6, envelope	Homo sapiens	73-76
33750987-3	2021	Anti-glycan antibodies, such as 2G12, target the HIV-1 envelope protein (Env), which is even more extensively glycosylated and contains under-processed oligomannose-type clusters on its dense glycan shield.	Polysaccharides	192-198	endogenous retrovirus group K member 6, envelope	Homo sapiens	55-71
33750987-3	2021	Anti-glycan antibodies, such as 2G12, target the HIV-1 envelope protein (Env), which is even more extensively glycosylated and contains under-processed oligomannose-type clusters on its dense glycan shield.	Polysaccharides	192-198	endogenous retrovirus group K member 6, envelope	Homo sapiens	73-76
33624653-6	2021	The scanning electron microscope (SEM) images of three polysaccharides showed that PSP-D has a smooth surface and a small curve, PSP-H is block-like and uneven in magnitude, whereas PSP-S is sea-tent-like and its surface is very distinct from the others.	Polysaccharides	55-70	surfactant protein D	Rattus norvegicus	83-88
33624653-4	2021	Three polysaccharide fractions, PSP-D, PSP-H and PSP-S, were sequentially extracted by different processes from the seed of Plantago asiatica L. The Fourier transform infrared spectral (FTIR) results showed that there were significant differences between PSP-S and the other two polysaccharides (PSP-D and PSP-H).	Polysaccharides	6-20	surfactant protein D	Rattus norvegicus	32-37
33484712-3	2021	Extensive structural and functional studies on this protein have rapidly advanced our understanding of the S-protein structure at atomic resolutions, while most of structural studies overlook the effect of glycans attached to S-protein on the conformational stability and functional motions between the inactive Down and the active Up forms.	Polysaccharides	206-213	vitronectin	Homo sapiens	226-235
33645601-2	2021	One potential drawback in using the native MUC1 glycopeptide for vaccine design is the instability of the O-glycosyl linkage between the glycan and the peptide backbone to glycosidase.	Polysaccharides	137-143	mucin 1, cell surface associated	Homo sapiens	43-47
33645601-4	2021	The resulting MUC1-beta-Tf had a much-enhanced stability toward a glycosidase capable of cleaving the glycan from the corresponding MUC1 glycopeptide with the natural alpha-Tf linkage.	Polysaccharides	102-108	mucin 1, cell surface associated	Homo sapiens	14-18
33645601-4	2021	The resulting MUC1-beta-Tf had a much-enhanced stability toward a glycosidase capable of cleaving the glycan from the corresponding MUC1 glycopeptide with the natural alpha-Tf linkage.	Polysaccharides	102-108	glial cell derived neurotrophic factor	Homo sapiens	19-26
33645601-4	2021	The resulting MUC1-beta-Tf had a much-enhanced stability toward a glycosidase capable of cleaving the glycan from the corresponding MUC1 glycopeptide with the natural alpha-Tf linkage.	Polysaccharides	102-108	mucin 1, cell surface associated	Homo sapiens	132-136
33728652-0	2021	Cryptococcus gattii evades CD11b-mediated fungal recognition by coating itself with capsular polysaccharides.	Polysaccharides	93-108	integrin subunit alpha M	Homo sapiens	27-32
33841142-0	2021	Polysaccharide Isolated From Tetrastigma hemsleyanum Activates TLR4 in Macrophage Cell Lines and Enhances Immune Responses in OVA-Immunized and LLC-Bearing Mouse Models.	Polysaccharides	0-14	toll like receptor 4	Homo sapiens	63-67
33657316-0	2021	Heterogeneity of Glycan Processing on Trimeric SARS-CoV-2 Spike Protein Revealed by Charge Detection Mass Spectrometry.	Polysaccharides	17-23	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	58-63
33483027-0	2021	The role of polysaccharides from natural resources to design oral insulin micro- and nanoparticles intended for the treatment of Diabetes mellitus: A review.	Polysaccharides	12-27	insulin	Homo sapiens	66-73
33540032-0	2021	P-selectin targeting polysaccharide-based nanogels for miRNA delivery.	Polysaccharides	21-35	selectin P	Homo sapiens	0-10
33586729-0	2021	The polysaccharides from the Grifola frondosa fruiting body prevent lipopolysaccharide/D-galactosamine-induced acute liver injury via the miR-122-Nrf2/ARE pathways.	Polysaccharides	4-19	microRNA 122	Mus musculus	138-145
33586729-0	2021	The polysaccharides from the Grifola frondosa fruiting body prevent lipopolysaccharide/D-galactosamine-induced acute liver injury via the miR-122-Nrf2/ARE pathways.	Polysaccharides	4-19	nuclear factor, erythroid derived 2, like 2	Mus musculus	146-150
33483067-6	2021	Simulations of polysaccharides of different chain lengths suggested the existence of a structural threshold for the formation of a spatial network for HG consisting of less than 35 GalA units.	Polysaccharides	15-30	galactosidase alpha	Homo sapiens	181-185
33586729-2	2021	However, the underlying mechanism governing how polysaccharides protect against acute liver injury induced by lipopolysaccharide/d-galactosamine (LPS/d-GalN) remains unclear.	Polysaccharides	48-63	galanin and GMAP prepropeptide	Mus musculus	152-156
33630563-1	2021	However, the affinities of most monovalent glycan-GBP complexes are typically weak (dissociation constant (Kd) > muM) and difficult to reliably measure with conventional assays; consequently, the glycan specificities of most GBPs are not well established.	Polysaccharides	43-49	transmembrane protein 132A	Homo sapiens	50-53
33497603-1	2021	Most mammals express a functional GGTA1 gene encoding the N-acetyllactosaminide alpha-1,3-galactosyltransferase enzyme, which synthesizes Gal-alpha1-3Gal-beta1-4GlcNAc (alpha-gal) and are thus tolerant to this self-expressed glycan.	Polysaccharides	225-231	glycoprotein alpha-galactosyltransferase 1 (inactive)	Homo sapiens	34-39
33497603-1	2021	Most mammals express a functional GGTA1 gene encoding the N-acetyllactosaminide alpha-1,3-galactosyltransferase enzyme, which synthesizes Gal-alpha1-3Gal-beta1-4GlcNAc (alpha-gal) and are thus tolerant to this self-expressed glycan.	Polysaccharides	225-231	glycoprotein galactosyltransferase alpha 1, 3	Mus musculus	169-178
33630563-1	2021	However, the affinities of most monovalent glycan-GBP complexes are typically weak (dissociation constant (Kd) > muM) and difficult to reliably measure with conventional assays; consequently, the glycan specificities of most GBPs are not well established.	Polysaccharides	196-202	transmembrane protein 132A	Homo sapiens	50-53
33758835-5	2021	Molecular dynamics (MD) simulations of a fully glycosylated spike support s a model of steric restrictions that shape enzymatic processing of the glycans.	Polysaccharides	146-153	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	60-65
33630563-2	2021	Here, we demonstrate how electrospray ionization mass spectrometry (ESI-MS), implemented with nanoflow ESI emitters with inner diameters of ~50 nm, allows for the facile quantification of low-affinity glycan-GBP interactions.	Polysaccharides	201-207	transmembrane protein 132A	Homo sapiens	208-211
33658363-6	2021	Glycan array studies confirmed the binding of HMGB1 to sialylated glycan sequences typically found on plasma glycoproteins, with binding again being dependent on zinc and normal blood pH.	Polysaccharides	0-6	high mobility group box 1	Homo sapiens	46-51
33658363-6	2021	Glycan array studies confirmed the binding of HMGB1 to sialylated glycan sequences typically found on plasma glycoproteins, with binding again being dependent on zinc and normal blood pH.	Polysaccharides	66-72	high mobility group box 1	Homo sapiens	46-51
33630563-3	2021	The small size of the droplets produced from these submicron emitters effectively eliminates the formation of nonspecific glycan-GBP binding (false positives) during the ESI process up to ~mM glycan concentrations.	Polysaccharides	122-128	transmembrane protein 132A	Homo sapiens	129-132
33630563-7	2021	Finally, we show how the use of submicron emitters and suppression of nonspecific binding enable the quantification of labile (prone to in-source dissociation) glycan-GBP interactions.	Polysaccharides	160-166	transmembrane protein 132A	Homo sapiens	167-170
33436261-2	2021	In this research, we found a polysaccharide called HDPS-4II from Holotrichia diomphalia Bates, which can specifically bind to ALDOA with a dissociation constant of 2.86 muM.	Polysaccharides	29-43	aldolase A, fructose-bisphosphate	Mus musculus	126-131
33838626-0	2021	Recombinant SARS-CoV-2 S Protein Binds to Glycans of the Lactosamine Family in vitro.	Polysaccharides	42-49	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	12-13
33838626-3	2021	We studied interaction of the recombinant SARS-CoV-2 spike (S) protein with an array of glycoconjugates, including various sialylated, sulfated, and other glycans, and found that the S protein binds some (but not all) glycans of the lactosamine family.	Polysaccharides	155-162	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	53-58
33838626-3	2021	We studied interaction of the recombinant SARS-CoV-2 spike (S) protein with an array of glycoconjugates, including various sialylated, sulfated, and other glycans, and found that the S protein binds some (but not all) glycans of the lactosamine family.	Polysaccharides	155-162	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	42-43
33838626-3	2021	We studied interaction of the recombinant SARS-CoV-2 spike (S) protein with an array of glycoconjugates, including various sialylated, sulfated, and other glycans, and found that the S protein binds some (but not all) glycans of the lactosamine family.	Polysaccharides	155-162	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	45-46
33838626-3	2021	We studied interaction of the recombinant SARS-CoV-2 spike (S) protein with an array of glycoconjugates, including various sialylated, sulfated, and other glycans, and found that the S protein binds some (but not all) glycans of the lactosamine family.	Polysaccharides	218-225	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	53-58
33838626-3	2021	We studied interaction of the recombinant SARS-CoV-2 spike (S) protein with an array of glycoconjugates, including various sialylated, sulfated, and other glycans, and found that the S protein binds some (but not all) glycans of the lactosamine family.	Polysaccharides	218-225	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	42-43
33838626-3	2021	We studied interaction of the recombinant SARS-CoV-2 spike (S) protein with an array of glycoconjugates, including various sialylated, sulfated, and other glycans, and found that the S protein binds some (but not all) glycans of the lactosamine family.	Polysaccharides	218-225	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	45-46
33663341-7	2021	The glycan increased the flexibility of hMOG and enhanced the interaction of MOG with water molecules.	Polysaccharides	4-10	myelin oligodendrocyte glycoprotein	Homo sapiens	41-44
33664400-2	2021	As a prime example of the significance of glycans, the ability of the cell surface receptor CD44 to bind its ligand, hyaluronan, is modulated by N-glycosylation.	Polysaccharides	42-49	CD44 molecule (Indian blood group)	Homo sapiens	92-96
33444795-11	2021	In the ELISA assay, a trend of EGF binding was detected for sulfated polysaccharides while QCM-D analysis showed negligible binding of insulin and EGF to sulfated substrates.	Polysaccharides	69-84	epidermal growth factor	Homo sapiens	31-34
33288424-0	2021	Impedimetric aptamer-based glycan PSA score for discrimination of prostate cancer from other prostate diseases.	Polysaccharides	27-33	kallikrein related peptidase 3	Homo sapiens	34-37
33288424-8	2021	The final output of the proposed platform is the ratio between PSAG-1 reactive PSA and total PSA, defined as the glycan score.	Polysaccharides	113-119	kallikrein related peptidase 3	Homo sapiens	63-66
33051777-1	2021	Heparanase is the predominant enzyme that cleaves heparan sulfate, the main polysaccharide in the extracellular matrix.	Polysaccharides	76-90	heparanase	Mus musculus	0-10
32946177-3	2021	It is found that polysaccharides in many plants and microorganisms have significant antioxidant effects, mainly through the endogenous antioxidant stress Nrf2/ARE pathway to regulate the expression of downstream antioxidant enzymes.	Polysaccharides	17-32	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
33465362-4	2021	The polysaccharides stimulated RAW264.7 cells to produce considerable amounts of NO and up-regulate the expression of TNF-alpha, IL-1 and COX-2 genes.	Polysaccharides	4-19	tumor necrosis factor	Mus musculus	118-127
33393720-0	2021	Mac-2 Binding Protein Glycan Isomer as non-invasive tool to assess liver fibrosis in children with chronic liver disease.	Polysaccharides	22-28	galectin 3 binding protein	Homo sapiens	0-21
32662414-8	2021	We further found that the glycan level of GlcNAc was positively correlated with that of complement 3 (C3), and that the reduced level of GlcNAc was associated with damage to multiple organs.	Polysaccharides	26-32	complement C3	Homo sapiens	88-100
32662414-8	2021	We further found that the glycan level of GlcNAc was positively correlated with that of complement 3 (C3), and that the reduced level of GlcNAc was associated with damage to multiple organs.	Polysaccharides	26-32	complement C3	Homo sapiens	102-104
33450344-4	2021	In this study, three polysaccharide fractions (BP1, BP2, BP3) were isolated from black mulberry by stepwise precipitation with 30%, 60%, and 90% of ethanol and analyzed by GPC, HPLC and FT-IR methods.	Polysaccharides	21-35	BP1	Homo sapiens	47-50
33465362-4	2021	The polysaccharides stimulated RAW264.7 cells to produce considerable amounts of NO and up-regulate the expression of TNF-alpha, IL-1 and COX-2 genes.	Polysaccharides	4-19	interleukin 1 complex	Mus musculus	129-133
33450344-4	2021	In this study, three polysaccharide fractions (BP1, BP2, BP3) were isolated from black mulberry by stepwise precipitation with 30%, 60%, and 90% of ethanol and analyzed by GPC, HPLC and FT-IR methods.	Polysaccharides	21-35	BP3	Homo sapiens	57-60
33326874-4	2021	METHODS: After showing that the viral spike protein harbors the ABO glycan epitopes when produced by cells expressing the relevant glycosyltransferases, like upper respiratory tract epithelial cells, we enrolled 290 patients with Covid-19 and 276 asymptomatic controls to compare their levels of natural ABO blood group antibodies.	Polysaccharides	68-74	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	64-67
33465362-4	2021	The polysaccharides stimulated RAW264.7 cells to produce considerable amounts of NO and up-regulate the expression of TNF-alpha, IL-1 and COX-2 genes.	Polysaccharides	4-19	cytochrome c oxidase II, mitochondrial	Mus musculus	138-143
33647064-7	2021	These glycosylation sites are conserved in the GPC of wild-type MACV, indicating that this is a phenotypic reversion for the chimeric MACV to gain those glycans crucial for infection in vivo.	Polysaccharides	153-160	glycophorin C (Gerbich blood group)	Homo sapiens	47-50
33647064-8	2021	Further studies indicated that the GPC mutant viruses with additional glycans became more resistant to neutralizing antibodies and more virulent in animals.	Polysaccharides	70-77	glycophorin C (Gerbich blood group)	Homo sapiens	35-38
33647064-10	2021	We also found that MACV lacking specific GPC glycans elicited higher levels of neutralizing antibodies against wild-type MACV.	Polysaccharides	45-52	glycophorin C (Gerbich blood group)	Homo sapiens	41-44
33647064-11	2021	Our findings revealed the critical role of specific glycans on GPC in arenavirus pathogenicity and have important implications for rational design of vaccines against this group of hemorrhagic fever-causing viruses.	Polysaccharides	52-59	glycophorin C (Gerbich blood group)	Homo sapiens	63-66
33640457-7	2021	Taken together, our data suggest that leukosialin on K562 is a counter-receptor for Siglec-7 on NK cells and that a cluster of the Sia-containing glycan epitope on leukosialin is key as trans-ligand for unmasking the cis-ligand.	Polysaccharides	146-152	sialic acid binding Ig like lectin 7	Homo sapiens	84-92
33229224-3	2021	Because biosynthesis of human natural killer-1 (HNK-1) is shown to be associated with the risk of schizophrenia, here we used mouse monoclonal Cat-315 antibody, which recognizes HNK-1 glycans on PNNs.	Polysaccharides	184-191	beta-1,3-glucuronyltransferase 1	Homo sapiens	48-53
33229224-3	2021	Because biosynthesis of human natural killer-1 (HNK-1) is shown to be associated with the risk of schizophrenia, here we used mouse monoclonal Cat-315 antibody, which recognizes HNK-1 glycans on PNNs.	Polysaccharides	184-191	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	178-183
33412195-4	2021	The potential multidimensional applications of nanofibers (filtration, antimicrobial, biosensor, gas sensor, energy storage, catalytic, and tissue engineering) originating from these polysaccharides and their major impacts on the properties, functionalities, and uses of these electrospun fibers are compared and critically examined.	Polysaccharides	183-198	gastrin	Homo sapiens	97-100
33635916-13	2021	The four macroprolactinaemic patients showed decreased relative amount of bisecting IgG2/3 glycans.	Polysaccharides	91-98	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	84-90
33717050-1	2020	Galectin (gal)-1, -3, and -9 are members of a family of glycan binding proteins that mediate complex interactions between decidual, inflammatory and trophoblast cells modulating several processes during gestation, control of the maternal immune system, and parturition.	Polysaccharides	56-62	galectin 1	Homo sapiens	0-28
33640457-7	2021	Taken together, our data suggest that leukosialin on K562 is a counter-receptor for Siglec-7 on NK cells and that a cluster of the Sia-containing glycan epitope on leukosialin is key as trans-ligand for unmasking the cis-ligand.	Polysaccharides	146-152	LOC105369247	Homo sapiens	164-175
33156953-0	2021	Targeting the CRD F-face of human galectin-3 and allosterically modulating glycan binding by angiostatic PTX008 and a structurally optimized derivative.	Polysaccharides	75-81	galectin 3	Homo sapiens	34-44
33577335-3	2021	Here we report our synthesis and evaluation of homogeneously glycosylated interleukin-17A (IL-17A), based on a synthetic approach combining solid-phase synthesis of (glyco)peptides, chemoenzymatic glycan modification on segments, and chemical ligations.	Polysaccharides	197-203	interleukin 17A	Homo sapiens	74-89
33577335-3	2021	Here we report our synthesis and evaluation of homogeneously glycosylated interleukin-17A (IL-17A), based on a synthetic approach combining solid-phase synthesis of (glyco)peptides, chemoenzymatic glycan modification on segments, and chemical ligations.	Polysaccharides	197-203	interleukin 17A	Homo sapiens	91-97
33560106-2	2021	Because these two epitopes are among malignant cell glycan displays, particularly when presented by mucin-1 (MUC1), assessing the influence of the site and frequency of glycosylation on lectin recognition will identify determinants governing this interplay.	Polysaccharides	52-58	mucin 1, cell surface associated	Homo sapiens	100-107
33560106-2	2021	Because these two epitopes are among malignant cell glycan displays, particularly when presented by mucin-1 (MUC1), assessing the influence of the site and frequency of glycosylation on lectin recognition will identify determinants governing this interplay.	Polysaccharides	52-58	mucin 1, cell surface associated	Homo sapiens	109-113
33560106-4	2021	Isothermal titration calorimetry (ITC) analysis of the binding of hMGL to this library of MUC1 glycopeptides revealed an enthalpy-driven process and an affinity enhancement of an order of magnitude with an increasing glycan count from 6-8 muM for monoglycosylated peptides to 0.6 muM for triglycosylated peptide.	Polysaccharides	217-223	C-type lectin domain containing 10A	Homo sapiens	66-70
33560106-4	2021	Isothermal titration calorimetry (ITC) analysis of the binding of hMGL to this library of MUC1 glycopeptides revealed an enthalpy-driven process and an affinity enhancement of an order of magnitude with an increasing glycan count from 6-8 muM for monoglycosylated peptides to 0.6 muM for triglycosylated peptide.	Polysaccharides	217-223	mucin 1, cell surface associated	Homo sapiens	90-94
33631374-4	2021	RESULTS: Intestinal alpha1-2-fucosylation was suppressed in WT mice after western diet feeding, and supplementation of alpha1-2-fucosylated glycans exacerbated obesity and steatohepatitis in these mice.	Polysaccharides	140-147	brain protein 1	Mus musculus	119-127
33340519-0	2021	Subtle influence of ACE2 glycan processing on SARS-CoV-2 recognition.	Polysaccharides	25-31	angiotensin converting enzyme 2	Homo sapiens	20-24
33340519-5	2021	We generated a panel of engineered ACE2 glycoforms which were analyzed by mass spectrometry to reveal the site-specific glycan modifications.	Polysaccharides	120-126	angiotensin converting enzyme 2	Homo sapiens	35-39
33340519-6	2021	We then probed the impact of ACE2 glycosylation on S binding and revealed a subtle sensitivity with hypersialylated or oligomannose-type glycans slightly impeding the interaction.	Polysaccharides	137-144	angiotensin converting enzyme 2	Homo sapiens	29-33
33340519-6	2021	We then probed the impact of ACE2 glycosylation on S binding and revealed a subtle sensitivity with hypersialylated or oligomannose-type glycans slightly impeding the interaction.	Polysaccharides	137-144	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	51-52
33680062-0	2021	Extension of Drosophila Lifespan by Astragalus polysaccharide through a Mechanism Dependent on Antioxidant and Insulin/IGF-1 Signaling.	Polysaccharides	47-61	Insulin-like receptor	Drosophila melanogaster	111-118
33677516-6	2021	Guanidine hydrochloride treatment of Streptococcus sp., which is known to extract bacterial cell surface glycan-rich components, abolished bacterial binding to recombinant MGL1/CD301a.	Polysaccharides	105-111	LLGL scribble cell polarity complex component 1	Homo sapiens	172-176
33677516-6	2021	Guanidine hydrochloride treatment of Streptococcus sp., which is known to extract bacterial cell surface glycan-rich components, abolished bacterial binding to recombinant MGL1/CD301a.	Polysaccharides	105-111	C-type lectin domain family 10, member A	Mus musculus	177-183
33665621-3	2021	We describe a protocol for detection of glycan-degrading enzyme activity in mouse and human fecal samples, namely sulfatase and four carbohydrate-active enzymes.	Polysaccharides	40-46	arylsulfatase family member H	Homo sapiens	114-123
33592143-4	2021	Elongating the glycan length to hexa- and deca-saccharides significantly enhanced Abeta affinity compared to the corresponding HS tetrasaccharide.	Polysaccharides	15-21	amyloid beta precursor protein	Homo sapiens	82-87
33534538-5	2021	In the second stage, glycolipid fragments from the matched GSL species, which contain both the lipid and glycans and thus shift due to lipid structural changes, are treated according to lipid rule-based matching to characterize the lipid compositions.	Polysaccharides	105-112	cathepsin A	Homo sapiens	59-62
33357858-2	2021	Results suggested calcium ions could bind CS chains forming polysaccharide-metal complex, and the maximum calcium holding capacity of CSCa reached 4.23 %.	Polysaccharides	60-74	citrate synthase	Homo sapiens	42-44
33314603-0	2021	Glycoengineering of NK Cells with Glycan Ligands of CD22 and Selectins for B-Cell Lymphoma Therapy.	Polysaccharides	34-40	CD22 molecule	Homo sapiens	52-56
33314603-7	2021	Our results suggest that nature killer cells modified with glycan ligands to CD22 and selectins promote both targeted killing of B lymphoma cells and improved trafficking to sites where the cancer cells reside, respectively.	Polysaccharides	59-65	CD22 molecule	Homo sapiens	77-81
33743328-9	2021	Also in BCAA-treated rats, intestinal zonula occludens gene expression was increased, whereas hepatic translocation of E. faecalis and serum capsular polysaccharide levels were reduced.	Polysaccharides	150-164	AT-rich interaction domain 4B	Rattus norvegicus	8-12
33377786-3	2021	We expand nanoparticle templating on polysaccharide colloids by introducing a new and facile process that leads to the growth of organic nanoparticles on CNF and ChNF in aqueous media.	Polysaccharides	37-51	NPHS1 adhesion molecule, nephrin	Homo sapiens	154-157
33562383-7	2021	This study developed various CFG-SPI DN hydrogels with diverse textures and structures, governed by the concentrations of protein/polysaccharide and pH values, and also contributes to the understanding of gum-protein interactions in DN hydrogels obtained under different conditions.	Polysaccharides	130-144	chromogranin A	Homo sapiens	33-36
33556148-0	2021	The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection.	Polysaccharides	11-17	complement C3	Homo sapiens	4-10
33556148-9	2021	The data demonstrate that the C3/465 glycan hole cluster was the dominant neutralization target in high titer protected RM, despite other co-circulating neutralizing and non-neutralizing specificities.	Polysaccharides	37-43	complement C3	Macaca mulatta	30-36
33546740-1	2021	This work presents an investigation on the composition and structure of polysaccharides from the roots of Tetrastigma hemsleyanum (THP) and its associated antioxidant activity.	Polysaccharides	72-87	uromodulin	Mus musculus	131-134
33323840-1	2021	polysaccharides reduce cerebral ischemia/reperfusion injury in mice by increasing myeloid cell leukemia 1 via the downregulation of miR-134.	Polysaccharides	0-15	myeloid cell leukemia sequence 1	Mus musculus	82-105
33090600-3	2021	This is mediated by the interaction of Lewis type glycan structures on the N-glycan of MOG to the DC-SIGN receptor on dendritic cells (DCs).	Polysaccharides	50-56	myelin oligodendrocyte glycoprotein	Homo sapiens	87-90
33323840-1	2021	polysaccharides reduce cerebral ischemia/reperfusion injury in mice by increasing myeloid cell leukemia 1 via the downregulation of miR-134.	Polysaccharides	0-15	microRNA 134	Mus musculus	132-139
33495350-0	2021	Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7.	Polysaccharides	60-66	sialic acid binding Ig like lectin 7	Homo sapiens	102-110
33545173-5	2021	The strongest signals were for glycans that contain either Manalpha1-2Man constituents or fucose in various linkages.	Polysaccharides	31-38	mannosidase alpha class 2C member 1	Homo sapiens	59-68
33495350-3	2021	Here, we present a CRISPRi genomic screening strategy that allowed unbiased identification of the key genes required for cell-surface presentation of glycan ligands on leukemia cells that bind the glyco-immune checkpoint receptors Siglec-7 and Siglec-9.	Polysaccharides	150-156	sialic acid binding Ig like lectin 7	Homo sapiens	231-239
33495350-3	2021	Here, we present a CRISPRi genomic screening strategy that allowed unbiased identification of the key genes required for cell-surface presentation of glycan ligands on leukemia cells that bind the glyco-immune checkpoint receptors Siglec-7 and Siglec-9.	Polysaccharides	150-156	sialic acid binding Ig like lectin 9	Homo sapiens	244-252
33421460-6	2021	The results showed that polysaccharides treatment inhibited the expression of Cyclin E, Cyclin A and CDK2 and up regulated the expression of P53.	Polysaccharides	24-39	cyclin A2	Homo sapiens	88-96
33197333-1	2021	Heparin and heparan sulfate (HS) are highly sulfated polysaccharides covalently bound to cell surface proteins, which directly interact with many extracellular proteins, including the transforming growth factor-beta (TGFbeta) family ligand antagonist, follistatin 288 (FS288).	Polysaccharides	53-68	tumor necrosis factor	Homo sapiens	184-215
33197333-1	2021	Heparin and heparan sulfate (HS) are highly sulfated polysaccharides covalently bound to cell surface proteins, which directly interact with many extracellular proteins, including the transforming growth factor-beta (TGFbeta) family ligand antagonist, follistatin 288 (FS288).	Polysaccharides	53-68	transforming growth factor alpha	Homo sapiens	217-224
33421460-6	2021	The results showed that polysaccharides treatment inhibited the expression of Cyclin E, Cyclin A and CDK2 and up regulated the expression of P53.	Polysaccharides	24-39	cyclin dependent kinase 2	Homo sapiens	101-105
33421460-6	2021	The results showed that polysaccharides treatment inhibited the expression of Cyclin E, Cyclin A and CDK2 and up regulated the expression of P53.	Polysaccharides	24-39	tumor protein p53	Homo sapiens	141-144
33087860-3	2021	Host-derived mucus glycans on gut-secreted mucin proteins serve as a continuous endogenous source of MACs for resident microbes; here we investigate the potential role of purified, orally administered mucus glycans in maintaining a healthy microbial community.	Polysaccharides	19-26	LOC100508689	Homo sapiens	43-48
32888232-6	2021	Moreover, in response to a pneumococcal polysaccharide vaccine, GPR43-deficient mice developed robust serum antibody responses and had markedly increased numbers of splenic antibody-secreting cells, compared with control mice.	Polysaccharides	40-54	free fatty acid receptor 2	Mus musculus	64-69
33347928-7	2021	Besides, polysaccharides show protective effects through certain signaling pathways including PI3K/Akt, MAPK, and NF-kappaB, PARP-1/AIF, JNK3/c-Jun/Fas-L, and Nrf2/HO-1 signaling pathways.	Polysaccharides	9-24	AKT serine/threonine kinase 1	Homo sapiens	99-102
33347928-7	2021	Besides, polysaccharides show protective effects through certain signaling pathways including PI3K/Akt, MAPK, and NF-kappaB, PARP-1/AIF, JNK3/c-Jun/Fas-L, and Nrf2/HO-1 signaling pathways.	Polysaccharides	9-24	nuclear factor kappa B subunit 1	Homo sapiens	114-123
33347928-7	2021	Besides, polysaccharides show protective effects through certain signaling pathways including PI3K/Akt, MAPK, and NF-kappaB, PARP-1/AIF, JNK3/c-Jun/Fas-L, and Nrf2/HO-1 signaling pathways.	Polysaccharides	9-24	poly(ADP-ribose) polymerase 1	Homo sapiens	125-131
33347928-7	2021	Besides, polysaccharides show protective effects through certain signaling pathways including PI3K/Akt, MAPK, and NF-kappaB, PARP-1/AIF, JNK3/c-Jun/Fas-L, and Nrf2/HO-1 signaling pathways.	Polysaccharides	9-24	apoptosis inducing factor mitochondria associated 1	Homo sapiens	132-135
33347928-7	2021	Besides, polysaccharides show protective effects through certain signaling pathways including PI3K/Akt, MAPK, and NF-kappaB, PARP-1/AIF, JNK3/c-Jun/Fas-L, and Nrf2/HO-1 signaling pathways.	Polysaccharides	9-24	mitogen-activated protein kinase 10	Homo sapiens	137-141
33347928-7	2021	Besides, polysaccharides show protective effects through certain signaling pathways including PI3K/Akt, MAPK, and NF-kappaB, PARP-1/AIF, JNK3/c-Jun/Fas-L, and Nrf2/HO-1 signaling pathways.	Polysaccharides	9-24	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	142-147
33347928-7	2021	Besides, polysaccharides show protective effects through certain signaling pathways including PI3K/Akt, MAPK, and NF-kappaB, PARP-1/AIF, JNK3/c-Jun/Fas-L, and Nrf2/HO-1 signaling pathways.	Polysaccharides	9-24	Fas ligand	Homo sapiens	148-153
33347928-7	2021	Besides, polysaccharides show protective effects through certain signaling pathways including PI3K/Akt, MAPK, and NF-kappaB, PARP-1/AIF, JNK3/c-Jun/Fas-L, and Nrf2/HO-1 signaling pathways.	Polysaccharides	9-24	NFE2 like bZIP transcription factor 2	Homo sapiens	159-163
33347928-7	2021	Besides, polysaccharides show protective effects through certain signaling pathways including PI3K/Akt, MAPK, and NF-kappaB, PARP-1/AIF, JNK3/c-Jun/Fas-L, and Nrf2/HO-1 signaling pathways.	Polysaccharides	9-24	heme oxygenase 1	Homo sapiens	164-168
33183436-7	2021	Hyaluronic acid is a natural polysaccharide, which has excellent biocompatibility and biodegradability, and has a good ability to actively target malignant tumor cells overexpressing the CD44 receptor.	Polysaccharides	29-43	CD44 molecule (Indian blood group)	Homo sapiens	187-191
33176060-9	2021	In addition to the chain length, the type and extent of sulfation of glycosaminoglycans influenced the ability of skeletal muscle myosin to neutralize the polysaccharide"s ability to enhance antithrombin"s activity.	Polysaccharides	155-169	serpin family C member 1	Homo sapiens	191-203
32583064-9	2021	Identifying and understanding the mechanisms by which glycosylation affects TGF-beta signaling and downstream biological responses will facilitate the identification of glycans as biomarkers and enable novel therapeutic approaches.	Polysaccharides	169-176	transforming growth factor alpha	Homo sapiens	76-84
33524390-6	2021	Structural analyses of glycans using lectins and LC-MS revealed that alpha2,3-sialylation is selectively enhanced, suggesting that an alpha2,3-sialyltransferase that catalyzes the sialyation of glycoproteins is activated or upregulated as the result of Rab11 knockdown.	Polysaccharides	23-30	immunoglobulin kappa variable 2-24	Homo sapiens	69-77
33524390-6	2021	Structural analyses of glycans using lectins and LC-MS revealed that alpha2,3-sialylation is selectively enhanced, suggesting that an alpha2,3-sialyltransferase that catalyzes the sialyation of glycoproteins is activated or upregulated as the result of Rab11 knockdown.	Polysaccharides	23-30	RAB11A, member RAS oncogene family	Homo sapiens	253-258
33532574-2	2021	In this paper, we identify differential levels of a specific glycan linkage: alpha2,6-linked sialic acids within breast cancer cells in vivo and in culture.	Polysaccharides	61-67	glycoprotein hormone subunit alpha 2	Homo sapiens	77-83
33376194-0	2021	Separation and identification of permethylated glycan isomers by reversed phase nanoLC-NSI-MSn.	Polysaccharides	47-53	moesin	Homo sapiens	91-94
33376194-5	2021	Here, we report an optimized workflow for LC-MS analysis of permethylated glycans that includes sample preparation, mobile phase optimization, and MSn method development to resolve structural isomers on-the-fly.	Polysaccharides	74-81	misshapen	Drosophila melanogaster	147-150
33376194-10	2021	The LC-MSn approach we report generates glycan isomeric separations, robust structural characterization, and is amenable to auto-sampling with associated throughput enhancements.	Polysaccharides	40-46	moesin	Homo sapiens	7-10
33476097-11	2021	To the best of our knowledge, HEXB is the first residual HCP reported to have impact on the glycan profile of a formulated drug product.	Polysaccharides	92-98	hexosaminidase subunit beta	Homo sapiens	30-34
33481336-3	2021	Human ACE2 is heavily glycosylated and its glycans impact on binding to the SARS-CoV-2 spike protein and virus infectivity.	Polysaccharides	43-50	angiotensin converting enzyme 2	Homo sapiens	6-10
33481336-3	2021	Human ACE2 is heavily glycosylated and its glycans impact on binding to the SARS-CoV-2 spike protein and virus infectivity.	Polysaccharides	43-50	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	87-92
33376017-2	2021	These glycans aid in a variety of biological functions such as cell interactions and immune response.	Polysaccharides	6-13	activation induced cytidine deaminase	Homo sapiens	14-17
33300777-7	2021	With the glycoprotein transferrin as a source of target glycan, two satisfied anti-A2G2S2 aptamers were selected within seven rounds.	Polysaccharides	56-62	transferrin	Homo sapiens	22-33
33399614-6	2021	The polysaccharide significantly increased the content of superoxide dismutase and catalase in the serum, liver and spleen of mice, and decreased the content of malondialdehyde in the serum, liver and spleen to a certain extent.	Polysaccharides	4-18	catalase	Mus musculus	83-91
33369397-0	2021	Lysosome-Mediated Cytotoxic Autophagy Contributes to Tea Polysaccharide-Induced Colon Cancer Cell Death via mTOR-TFEB Signaling.	Polysaccharides	57-71	mechanistic target of rapamycin kinase	Homo sapiens	108-112
33369397-0	2021	Lysosome-Mediated Cytotoxic Autophagy Contributes to Tea Polysaccharide-Induced Colon Cancer Cell Death via mTOR-TFEB Signaling.	Polysaccharides	57-71	transcription factor EB	Homo sapiens	113-117
33478164-4	2021	SPR studies revealed that all the tested polysaccharides bind to FGF-2 (with exception of CS-8, CS-12 and CS-13) according to a model in which the CSs first form a weak complex with the protein, which is followed by maturation to tight binding with kD ranging affinities from ~ 1.31 muM to 130 muM for the first step and from ~ 3.88 muM to 1.8 nM for the second one.	Polysaccharides	41-56	fibroblast growth factor 2	Homo sapiens	65-70
33495714-0	2021	Binding of the SARS-CoV-2 Spike Protein to Glycans.	Polysaccharides	43-50	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	26-31
33495714-4	2021	In this study, we examined and compared the binding of the subunits and spike (S) proteins of SARS-CoV-2 and SARS-CoV, MERS-CoV to these glycans.	Polysaccharides	137-144	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	72-77
33183626-6	2021	The polysaccharide could significantly increase the content of SOD and CAT in serum, liver and spleen tissue of mice, and reduce the content of MDA in serum, liver and spleen tissue to a certain extent.	Polysaccharides	4-18	catalase	Mus musculus	71-74
33183632-0	2021	Chemical structure and inhibition on alpha-glucosidase of polysaccharides from corn silk by fractional precipitation.	Polysaccharides	58-73	sucrase-isomaltase	Homo sapiens	37-54
33250160-3	2021	In recent years, asymmetrical flow field-flow fractionation (AF4) has been widely used in the separation and characterization of polysaccharides because it has no stationary phases or packing materials, which reduces the risk of shear degradation of polysaccharides.	Polysaccharides	129-144	AF4/FMR2 family member 1	Homo sapiens	61-64
33278434-2	2021	In this study, we report a new strategy for preparing injectable and conductive polysaccharides-based hydrogels that could sustainably deliver brain-derived neurotrophic factor (BDNF) for SCI repair.	Polysaccharides	80-95	brain derived neurotrophic factor	Homo sapiens	143-176
33278434-2	2021	In this study, we report a new strategy for preparing injectable and conductive polysaccharides-based hydrogels that could sustainably deliver brain-derived neurotrophic factor (BDNF) for SCI repair.	Polysaccharides	80-95	brain derived neurotrophic factor	Homo sapiens	178-182
33278434-5	2021	The polysaccharides-based hydrogel composed of oxidized dextran (Dex) and hyaluronic acid-hydrazide (HA) was mixed with TA-modified microspheres to form the ultimate BDNF@TA-PLGA/Dex-HA hydrogel.	Polysaccharides	4-19	brain derived neurotrophic factor	Homo sapiens	166-170
33395290-2	2021	This strategy was highlighted by using a simple lactoside containing the core structures of GSL glycan and lipid as the universal starting material to obtain different synthetic targets upon stepwise elongation of the glycan via chemical glycosylations and on-site remodeling of the lipid via chemoselective cross-metathesis and N-acylation.	Polysaccharides	96-102	cathepsin A	Homo sapiens	92-95
33177194-8	2021	Finally, we identify several triple bNAb combinations comprised of CD4 binding site, V2-glycan, and gp120-gp41 interface targeting bNAbs that are capable of mediating, synergistic polyfunctional antiviral activities against multiple clade A, B, C, and D SHIVs.IMPORTANCE Optimal bNAb immunotherapeutics will need to mediate multiple antiviral functions against a broad range of HIV strains.	Polysaccharides	88-94	CD4 molecule	Homo sapiens	67-70
33177194-8	2021	Finally, we identify several triple bNAb combinations comprised of CD4 binding site, V2-glycan, and gp120-gp41 interface targeting bNAbs that are capable of mediating, synergistic polyfunctional antiviral activities against multiple clade A, B, C, and D SHIVs.IMPORTANCE Optimal bNAb immunotherapeutics will need to mediate multiple antiviral functions against a broad range of HIV strains.	Polysaccharides	88-94	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	100-105
32501471-6	2021	However, using a microarray of diverse, structurally-defined glycans, we show that Siglec-15 binds with higher avidity to sialylated glycans other than sTn or related antigen sequences.	Polysaccharides	61-68	sialic acid binding Ig like lectin 15	Homo sapiens	83-92
32501471-6	2021	However, using a microarray of diverse, structurally-defined glycans, we show that Siglec-15 binds with higher avidity to sialylated glycans other than sTn or related antigen sequences.	Polysaccharides	133-140	sialic acid binding Ig like lectin 15	Homo sapiens	83-92
33212049-1	2021	As hyperlipidemia was a pathological progress by lipid dysfunctions, the present object was to investigate the hypolipidemic and hepatoprotective effects of Auricularia auricular residue polysaccharides (RPS) against HFE (high-fat emulsion) toxicities in mice.	Polysaccharides	187-202	homeostatic iron regulator	Mus musculus	217-220
33305950-5	2021	Specifically, the anomeric C1/H1 resonances from N-acetylglucosamine (GlcNAc2 and -5) and mannose (Man4) were identified as characteristic peaks for key glycan anomeric linkages and branching states.	Polysaccharides	153-159	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	27-84
33467462-2	2021	CS is a polysaccharide with beneficial properties; however, its printing behavior is not satisfying, rendering the addition of a thickening agent necessary, i.e., PEC.	Polysaccharides	8-22	citrate synthase	Homo sapiens	0-2
33519818-5	2020	We isolated AACT from plasma depleted for albumin, IgG and serotransferrin and used high-resolution native mass spectrometry to qualitatively and quantitatively monitor the multifaceted glycan microheterogeneity of desialylated AACT, which allowed us to monitor how changes in the glycoproteoform profiles reflected the patient"s physiological state.	Polysaccharides	186-192	serpin family A member 3	Homo sapiens	12-16
33441599-4	2021	The phenylalanine ammonia lyase (PAL), chitinase, 1,3-beta-glucanase and peroxidase (POX) activities have been improved in tomato plants leaves treated by polysaccharides extracted from <compound-id="-">P.	Polysaccharides	155-170	phenylalanine ammonia-lyase	Solanum lycopersicum	4-31
33441599-4	2021	The phenylalanine ammonia lyase (PAL), chitinase, 1,3-beta-glucanase and peroxidase (POX) activities have been improved in tomato plants leaves treated by polysaccharides extracted from <compound-id="-">P.	Polysaccharides	155-170	phenylalanine ammonia-lyase	Solanum lycopersicum	33-36
33441599-4	2021	The phenylalanine ammonia lyase (PAL), chitinase, 1,3-beta-glucanase and peroxidase (POX) activities have been improved in tomato plants leaves treated by polysaccharides extracted from <compound-id="-">P.	Polysaccharides	155-170	peroxidase	Solanum lycopersicum	73-83
33441599-4	2021	The phenylalanine ammonia lyase (PAL), chitinase, 1,3-beta-glucanase and peroxidase (POX) activities have been improved in tomato plants leaves treated by polysaccharides extracted from <compound-id="-">P.	Polysaccharides	155-170	peroxidase	Solanum lycopersicum	85-88
33436985-2	2021	The aim of this study was to investigate the broad spectrum antiviral activity of a naturally existing sulfated polysaccharide, lambda-carrageenan (lambda-CGN), purified from marine red algae.	Polysaccharides	112-126	cingulin	Homo sapiens	155-158
33411760-4	2021	Both gal-1 and CXCL4 have high affinities for polysaccharides, and thus may mutually influence their functions.	Polysaccharides	46-61	galectin 1	Homo sapiens	5-10
33411760-4	2021	Both gal-1 and CXCL4 have high affinities for polysaccharides, and thus may mutually influence their functions.	Polysaccharides	46-61	platelet factor 4	Homo sapiens	15-20
32882654-1	2021	Paramylon is a long-chain polysaccharide, composed of glucose units connected via beta-(1,3) glycosidic bonds, that spontaneously forms a three-strand helical bundle.	Polysaccharides	26-40	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	82-91
33406789-0	2021	Tracking of Glycans Structure and Metallomics Profiles in BRAF Mutated Melanoma Cells Treated with Vemurafenib.	Polysaccharides	12-19	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	58-62
33250160-3	2021	In recent years, asymmetrical flow field-flow fractionation (AF4) has been widely used in the separation and characterization of polysaccharides because it has no stationary phases or packing materials, which reduces the risk of shear degradation of polysaccharides.	Polysaccharides	250-265	AF4/FMR2 family member 1	Homo sapiens	61-64
33250160-5	2021	The operation conditions of AF4 for the analysis of polysaccharides were discussed.	Polysaccharides	52-67	AF4/FMR2 family member 1	Homo sapiens	28-31
33250160-6	2021	The applications of AF4 for the separation and characterization of polysaccharides from different sources (plants, animals, and microorganisms) over the last decade were critically reviewed.	Polysaccharides	67-82	AF4/FMR2 family member 1	Homo sapiens	20-23
32949621-0	2021	Design and characterization of a germ-line targeting soluble, native-like, trimeric HIV-1 Env lacking key glycans from the V1V2-loop.	Polysaccharides	106-113	endogenous retrovirus group K member 20	Homo sapiens	90-93
33288196-7	2021	Cancer-related glycan epitopes such as Lewis A and Lewis Y were detected in core 3 O-glycans of both PC3 and PC42.	Polysaccharides	15-21	proprotein convertase subtilisin/kexin type 1	Mus musculus	101-104
32949621-4	2021	An alternate approach is to design Env protein with glycan deletion to expose the protein surface.	Polysaccharides	52-58	endogenous retrovirus group K member 20	Homo sapiens	35-38
32949621-5	2021	METHODS: A stable native-like trimeric Env with glycan holes at potentially immunogenic locations is expected to elicit better induction of germ-line B-cells due to exposure of the immunogenic regions.	Polysaccharides	48-54	endogenous retrovirus group K member 20	Homo sapiens	39-42
32949621-7	2021	In this work, we have designed a construct with glycans deleted from the trimer apex of an Indian clade C origin Env that has previously been characterized for immunogenicity, to understand the impact of deglycosylation on the structural and functional integrity as well as on the antibody binding properties.	Polysaccharides	48-55	endogenous retrovirus group K member 20	Homo sapiens	113-116
32949621-10	2021	CONCLUSIONS: This study provide an important design aspect of HIV-1 Env-based immunogens with glycan holes in the apex region that could be useful in eliciting apex directed antibodies in immunization studies.	Polysaccharides	94-100	endogenous retrovirus group K member 20	Homo sapiens	68-71
33142641-1	2021	The polysaccharide-based biomaterials hyaluronic acid (HA) and chondroitin sulfate (CS) have aroused great interest for use in drug delivery systems for tumor therapy, as they have outstanding biocompatibility and great targeting ability for cluster determinant 44 (CD44).	Polysaccharides	4-18	citrate synthase	Homo sapiens	84-86
33840686-2	2021	C-type lectin receptors (CLRs), the representative PRRs, bind to microbial polysaccharides, among which Dectin-2 and Mincle recognize mannose-containing polysaccharides.	Polysaccharides	75-90	C-type lectin domain family 4, member n	Mus musculus	104-112
33840686-2	2021	C-type lectin receptors (CLRs), the representative PRRs, bind to microbial polysaccharides, among which Dectin-2 and Mincle recognize mannose-containing polysaccharides.	Polysaccharides	75-90	C-type lectin domain family 4, member e	Mus musculus	117-123
33840686-2	2021	C-type lectin receptors (CLRs), the representative PRRs, bind to microbial polysaccharides, among which Dectin-2 and Mincle recognize mannose-containing polysaccharides.	Polysaccharides	153-168	C-type lectin domain family 4, member n	Mus musculus	104-112
33840686-2	2021	C-type lectin receptors (CLRs), the representative PRRs, bind to microbial polysaccharides, among which Dectin-2 and Mincle recognize mannose-containing polysaccharides.	Polysaccharides	153-168	C-type lectin domain family 4, member e	Mus musculus	117-123
33618527-3	2021	RESULTS: The result of glycan analysis supports the assumption of a supposed glycosylation disorder and also specifies a specific subtype: CDG-1, subtype ALG12-CDG (Ig).	Polysaccharides	23-29	phosphomannomutase 2	Homo sapiens	139-144
33618527-3	2021	RESULTS: The result of glycan analysis supports the assumption of a supposed glycosylation disorder and also specifies a specific subtype: CDG-1, subtype ALG12-CDG (Ig).	Polysaccharides	23-29	ALG12 alpha-1,6-mannosyltransferase	Homo sapiens	154-159
33177111-2	2021	ST3GAL1 is a sialyltransferase that adds sialic acid to core 1 glycans, thereby terminating glycan chain extension.	Polysaccharides	63-70	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	0-7
33177111-2	2021	ST3GAL1 is a sialyltransferase that adds sialic acid to core 1 glycans, thereby terminating glycan chain extension.	Polysaccharides	63-69	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	0-7
32975882-4	2021	In interleukin-10 deficient mice, changes in the gut microbiota were accompanied by decreased carbohydrate hydrolase activities and increased lumenal concentrations of host glycan-derived monosaccharides.	Polysaccharides	173-179	interleukin 10	Mus musculus	3-17
33227824-7	2021	I incubated Endo H-treated CTR ECD with excess of glycan-free RAMP2 ECD to produce the RAMP2 ECD:CTR ECD complex.	Polysaccharides	50-56	receptor activity modifying protein 2	Homo sapiens	62-67
33274843-3	2021	As well as inorganic particles, a protein corona (PC) around polysaccharide nanoparticles is formed in biofluids.	Polysaccharides	61-75	pyruvate carboxylase	Homo sapiens	50-52
33227824-7	2021	I incubated Endo H-treated CTR ECD with excess of glycan-free RAMP2 ECD to produce the RAMP2 ECD:CTR ECD complex.	Polysaccharides	50-56	receptor activity modifying protein 2	Homo sapiens	87-92
33249124-1	2021	Intelectin (ITLN) is a type of glycan-binding lectin involved in many physiological processes and some human diseases.	Polysaccharides	31-37	intelectin 1	Homo sapiens	0-10
33249124-1	2021	Intelectin (ITLN) is a type of glycan-binding lectin involved in many physiological processes and some human diseases.	Polysaccharides	31-37	intelectin 1	Homo sapiens	12-16
33573443-5	2021	To address this, we characterized the bacterial glycoprofile and evaluated the involvement of human beta-galactoside-binding lectins, Galectin-1 (Gal-1) and Galectin-3 (Gal-3) which are highly expressed by macrophages as receptors for bacterial glycans.	Polysaccharides	245-252	galectin 3	Homo sapiens	169-174
33625256-0	2021	EXPRESSION OF CONCERN: "Astragalus polysaccharide alleviates LPS-induced inflammation injury by regulating miR-127 in H9c2 cardiomyoblasts".	Polysaccharides	35-49	microRNA 127	Homo sapiens	107-114
32506457-4	2021	MS/MS analysis of two glycan biomarkers, dp5 and A2G2, shows high elevation in newborn DBS from GM1-gangliosidosis compared to the levels in the non-affected reference range.	Polysaccharides	22-28	harakiri, BCL2 interacting protein	Homo sapiens	41-44
33583212-0	2021	Astragalus Polysaccharide Injection (PG2) Normalizes the Neutrophil-to-Lymphocyte Ratio in Patients with Advanced Lung Cancer Receiving Immunotherapy.	Polysaccharides	11-25	delta like non-canonical Notch ligand 1	Homo sapiens	37-40
33583212-4	2021	Astragalus polysaccharide injection (PG2) is an immunomodulatory therapy for cancer-related fatigue.	Polysaccharides	11-25	delta like non-canonical Notch ligand 1	Homo sapiens	37-40
33403027-9	2021	Moreover, gene set enrichment analysis showed that cases of HNSCC with FOXD1 overexpression were enriched in bladder cancer, cell cycle, DNA replication, glycosaminoglycan biosynthesis chondroitin sulfate, homologous recombination, glycan biosynthesis, nucleotide excision repair, p53 signaling pathway, pyrimidine metabolism, and spliceosome pathways.	Polysaccharides	165-171	forkhead box D1	Homo sapiens	71-76
33219555-8	2021	PRACTICAL APPLICATIONS: Large deals of researches have shown that indigestible polysaccharides possess an outstanding regulation effect on the intestinal microflora, which indicates that indigestible polysaccharides have the potential to be used as prebiotics in the functional food and pharmaceutical industries.	Polysaccharides	79-94	PRAC1 small nuclear protein	Homo sapiens	0-9
33219555-8	2021	PRACTICAL APPLICATIONS: Large deals of researches have shown that indigestible polysaccharides possess an outstanding regulation effect on the intestinal microflora, which indicates that indigestible polysaccharides have the potential to be used as prebiotics in the functional food and pharmaceutical industries.	Polysaccharides	200-215	PRAC1 small nuclear protein	Homo sapiens	0-9
33196194-6	2021	The glycan structure with the highest abundance was FA2, with a relative abundance of 52% in sample A and 38% in sample B.	Polysaccharides	4-10	FA complementation group B	Homo sapiens	52-55
33073996-6	2021	Molecular modeling of PD-L1/PD-1 interaction with N-glycans suggests that glycans at the N219 site of PD-L1 and N74 and N116 of PD-1 may be involved in glycan-glycan interactions, but the impact of this potential interaction on the protein function remains at this point unknown.	Polysaccharides	52-59	CD274 molecule	Homo sapiens	22-27
33073996-6	2021	Molecular modeling of PD-L1/PD-1 interaction with N-glycans suggests that glycans at the N219 site of PD-L1 and N74 and N116 of PD-1 may be involved in glycan-glycan interactions, but the impact of this potential interaction on the protein function remains at this point unknown.	Polysaccharides	52-59	programmed cell death 1	Homo sapiens	28-32
33073996-6	2021	Molecular modeling of PD-L1/PD-1 interaction with N-glycans suggests that glycans at the N219 site of PD-L1 and N74 and N116 of PD-1 may be involved in glycan-glycan interactions, but the impact of this potential interaction on the protein function remains at this point unknown.	Polysaccharides	52-59	CD274 molecule	Homo sapiens	102-107
33073996-4	2021	We demonstrate that PD-L1 on the surface of breast cancer cell line carries mostly complex glycans with a high proportion of polyLacNAc structures at the N219 sequon.	Polysaccharides	91-98	CD274 molecule	Homo sapiens	20-25
33073996-6	2021	Molecular modeling of PD-L1/PD-1 interaction with N-glycans suggests that glycans at the N219 site of PD-L1 and N74 and N116 of PD-1 may be involved in glycan-glycan interactions, but the impact of this potential interaction on the protein function remains at this point unknown.	Polysaccharides	52-59	programmed cell death 1	Homo sapiens	128-132
33140083-0	2021	Polysaccharides extracted from Rheum tanguticum ameliorate radiation-induced enteritis via activation of Nrf2/HO-1.	Polysaccharides	0-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	105-109
33073996-6	2021	Molecular modeling of PD-L1/PD-1 interaction with N-glycans suggests that glycans at the N219 site of PD-L1 and N74 and N116 of PD-1 may be involved in glycan-glycan interactions, but the impact of this potential interaction on the protein function remains at this point unknown.	Polysaccharides	52-58	CD274 molecule	Homo sapiens	22-27
33073996-6	2021	Molecular modeling of PD-L1/PD-1 interaction with N-glycans suggests that glycans at the N219 site of PD-L1 and N74 and N116 of PD-1 may be involved in glycan-glycan interactions, but the impact of this potential interaction on the protein function remains at this point unknown.	Polysaccharides	52-58	programmed cell death 1	Homo sapiens	28-32
33073996-6	2021	Molecular modeling of PD-L1/PD-1 interaction with N-glycans suggests that glycans at the N219 site of PD-L1 and N74 and N116 of PD-1 may be involved in glycan-glycan interactions, but the impact of this potential interaction on the protein function remains at this point unknown.	Polysaccharides	52-58	CD274 molecule	Homo sapiens	102-107
33073996-6	2021	Molecular modeling of PD-L1/PD-1 interaction with N-glycans suggests that glycans at the N219 site of PD-L1 and N74 and N116 of PD-1 may be involved in glycan-glycan interactions, but the impact of this potential interaction on the protein function remains at this point unknown.	Polysaccharides	52-58	programmed cell death 1	Homo sapiens	128-132
33073996-6	2021	Molecular modeling of PD-L1/PD-1 interaction with N-glycans suggests that glycans at the N219 site of PD-L1 and N74 and N116 of PD-1 may be involved in glycan-glycan interactions, but the impact of this potential interaction on the protein function remains at this point unknown.	Polysaccharides	74-80	CD274 molecule	Homo sapiens	22-27
33073996-6	2021	Molecular modeling of PD-L1/PD-1 interaction with N-glycans suggests that glycans at the N219 site of PD-L1 and N74 and N116 of PD-1 may be involved in glycan-glycan interactions, but the impact of this potential interaction on the protein function remains at this point unknown.	Polysaccharides	74-80	programmed cell death 1	Homo sapiens	28-32
33073996-6	2021	Molecular modeling of PD-L1/PD-1 interaction with N-glycans suggests that glycans at the N219 site of PD-L1 and N74 and N116 of PD-1 may be involved in glycan-glycan interactions, but the impact of this potential interaction on the protein function remains at this point unknown.	Polysaccharides	74-80	CD274 molecule	Homo sapiens	102-107
33073996-6	2021	Molecular modeling of PD-L1/PD-1 interaction with N-glycans suggests that glycans at the N219 site of PD-L1 and N74 and N116 of PD-1 may be involved in glycan-glycan interactions, but the impact of this potential interaction on the protein function remains at this point unknown.	Polysaccharides	74-80	programmed cell death 1	Homo sapiens	128-132
33140083-0	2021	Polysaccharides extracted from Rheum tanguticum ameliorate radiation-induced enteritis via activation of Nrf2/HO-1.	Polysaccharides	0-15	heme oxygenase 1	Rattus norvegicus	110-114
33110234-7	2021	LGALS2 encodes the glycan-binding protein Galectin 2 (Gal2), which is predominantly expressed in the gastrointestinal tract and downregulated in human colon tumors.	Polysaccharides	19-25	galectin 2	Homo sapiens	0-6
33908017-3	2021	Thus, when using glycan node analysis, unique glycan features within whole biospecimens such as "core fucosylation," "alpha2-6 sialylation," "beta1-6 branching," "beta1-4 branching," and "bisecting GlcNAc," are captured as single analytical signals by GC-MS.	Polysaccharides	46-52	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	118-126
33908017-3	2021	Thus, when using glycan node analysis, unique glycan features within whole biospecimens such as "core fucosylation," "alpha2-6 sialylation," "beta1-6 branching," "beta1-4 branching," and "bisecting GlcNAc," are captured as single analytical signals by GC-MS.	Polysaccharides	46-52	immunoglobulin kappa variable 3-31 (pseudogene)	Homo sapiens	142-149
33908017-3	2021	Thus, when using glycan node analysis, unique glycan features within whole biospecimens such as "core fucosylation," "alpha2-6 sialylation," "beta1-6 branching," "beta1-4 branching," and "bisecting GlcNAc," are captured as single analytical signals by GC-MS.	Polysaccharides	46-52	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	163-170
33908017-4	2021	Here we describe the use of this methodology in cell culture supernatant and in the analysis of IgG (alpha-1 antitrypsin) glycans.	Polysaccharides	122-129	serpin family A member 1	Homo sapiens	101-120
33908011-1	2021	EPO has a complex glycosylation pattern with differently branched and charged glycans.	Polysaccharides	78-85	erythropoietin	Homo sapiens	0-3
33908016-3	2021	Sialic acid chemical derivatization can be used to determine the isomeric linkage (alpha2,3 or alpha2,6) of sialic acids attached to N-glycans, while endoglycosidase F3 (Endo F3) can be enzymatically applied to preferentially release alpha1,6-linked core fucosylated glycans, further describing the linkage of fucose on N-glycans.	Polysaccharides	135-142	immunoglobulin kappa variable 2-24	Homo sapiens	83-91
33908016-3	2021	Sialic acid chemical derivatization can be used to determine the isomeric linkage (alpha2,3 or alpha2,6) of sialic acids attached to N-glycans, while endoglycosidase F3 (Endo F3) can be enzymatically applied to preferentially release alpha1,6-linked core fucosylated glycans, further describing the linkage of fucose on N-glycans.	Polysaccharides	135-142	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	95-103
32816187-9	2021	G81 glycan-binding 25 kDa fibroblast growth factor-1 (FGF1) fragment was also identified by N-terminal sequencing.	Polysaccharides	4-10	fibroblast growth factor 1	Homo sapiens	26-52
32816187-9	2021	G81 glycan-binding 25 kDa fibroblast growth factor-1 (FGF1) fragment was also identified by N-terminal sequencing.	Polysaccharides	4-10	fibroblast growth factor 1	Homo sapiens	54-58
32816187-10	2021	Our results demonstrated that a multiplex diagnostic combining G81 glycan-binding auto-IgG, GDF-15/NAG-1 and PSA (>= 2.1 ng PSA/ml for cancer) increased the specificity of prostate cancer diagnosis by 8%.	Polysaccharides	67-73	kallikrein related peptidase 3	Homo sapiens	124-127
33110234-7	2021	LGALS2 encodes the glycan-binding protein Galectin 2 (Gal2), which is predominantly expressed in the gastrointestinal tract and downregulated in human colon tumors.	Polysaccharides	19-25	galectin 2	Homo sapiens	54-58
33425974-7	2020	The FUT2 gene is responsible for the composition and functional properties of glycans in mucosal tissues and bodily secretions, including human milk.	Polysaccharides	78-85	fucosyltransferase 2	Homo sapiens	4-8
33458518-2	2021	In this study, polysaccharides from B. striata (BSP) were extracted by hot water.	Polysaccharides	15-30	black spleen	Mus musculus	48-51
33370382-5	2020	Analyses of site-specific glycans revealed that SP swapping altered Env glycan content and occupancy on multiple N-linked glycosites, including conserved N156 and N160 glycans in the V1V2 region at the Env trimer apex and N88 at the trimer base.	Polysaccharides	26-33	endogenous retrovirus group W member 1, envelope	Homo sapiens	68-71
33370382-5	2020	Analyses of site-specific glycans revealed that SP swapping altered Env glycan content and occupancy on multiple N-linked glycosites, including conserved N156 and N160 glycans in the V1V2 region at the Env trimer apex and N88 at the trimer base.	Polysaccharides	26-32	endogenous retrovirus group W member 1, envelope	Homo sapiens	68-71
33370382-5	2020	Analyses of site-specific glycans revealed that SP swapping altered Env glycan content and occupancy on multiple N-linked glycosites, including conserved N156 and N160 glycans in the V1V2 region at the Env trimer apex and N88 at the trimer base.	Polysaccharides	168-175	endogenous retrovirus group W member 1, envelope	Homo sapiens	68-71
33370382-8	2020	These data highlight the contribution of SP sequence diversity in shaping the Env glycan content and its impact on the configuration and accessibility of V1V2 and other Env epitopes.	Polysaccharides	82-88	endogenous retrovirus group W member 1, envelope	Homo sapiens	78-81
34050866-5	2021	CALR also buffers calcium ion release and mediates other glycan-independent protein interactions.	Polysaccharides	57-63	calreticulin	Homo sapiens	0-4
33326210-1	2020	The P22 tailspike endorhamnosidase confers the high specificity of bacteriophage P22 for some serogroups of Salmonella differing only slightly in their O-antigen polysaccharide.	Polysaccharides	162-176	p22 tailspike endorhamnosidase	None	4-34
33049862-5	2020	Overall, the present study elucidated that a new polysaccharide structure CYP-1 from Chinese yam and its therapeutic potential as a prebiotic for the prevention of inflammatory bowel disease.	Polysaccharides	49-63	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	74-79
33361123-5	2020	In contrast to previous reports in adults, both groups of children showed high levels of gp120-specific IgG Fc glycan sialylation compared to bulk IgG.	Polysaccharides	111-117	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	89-94
32915505-1	2020	The glycan structures of the receptor binding domain of the SARS-CoV2 spike glycoprotein expressed in human HEK293F cells have been studied by using NMR.	Polysaccharides	4-10	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	70-75
33353134-11	2020	Moreover, extracellular matrix remodelling, glycan metabolism and inflammation-related pathways were up-regulated in DEB1.	Polysaccharides	44-50	SS18, nBAF chromatin remodeling complex subunit like 2	Mus musculus	117-121
33356751-1	2021	Platelet Endothelial Aggregation Receptor 1 (PEAR1) is an orphan receptor of unknown function which mediates powerful activation of platelets and endothelial cells in response to crosslinking by antibodies and sulfated polysaccharides belonging to the dextran and fucoidan families.	Polysaccharides	219-234	platelet endothelial aggregation receptor 1	Homo sapiens	0-43
33356751-1	2021	Platelet Endothelial Aggregation Receptor 1 (PEAR1) is an orphan receptor of unknown function which mediates powerful activation of platelets and endothelial cells in response to crosslinking by antibodies and sulfated polysaccharides belonging to the dextran and fucoidan families.	Polysaccharides	219-234	platelet endothelial aggregation receptor 1	Homo sapiens	45-50
33391282-4	2020	LAD type 2 (LAD2) is caused by mutations in the SLC35C1 gene leading to a generalized loss of expression of fucosylated glycans on the cell surface and LAD type 3 (LAD3) is caused by mutations in the FERMT3 gene resulting in platelet function defects along with immunodeficiency.	Polysaccharides	120-127	solute carrier family 35 member C1	Homo sapiens	48-55
33218493-1	2020	Here, a novel electrochemiluminescence biosensor based on potential-resolved strategy was firstly prepared for the detection of dual targets alpha2,3-sialylated glycans and alpha2,6-sialylated glycans.	Polysaccharides	161-168	immunoglobulin kappa variable 2-24	Homo sapiens	141-149
33186018-4	2020	These oligo-DNA/polysaccharide complexes can be used as a tool for delivering therapeutic oligonucleotides to immunocytes that express the beta-1,3-d-glucan receptors.	Polysaccharides	16-30	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	139-147
33058984-4	2020	The electrostatic attractions between polysaccharides were studied by FT-IR, XRD, XPS, and TGA.	Polysaccharides	38-53	T-box transcription factor 1	Homo sapiens	91-94
33381142-9	2020	These results reveal the diverse changes in HRGP-related processes that occur during wood formation at the gene expression and HRGP glycan biosynthesis levels, and relate HRGPs and glycosylation processes to the developmental processes of wood formation.	Polysaccharides	132-138	histidine rich glycoprotein	Homo sapiens	44-48
33381142-9	2020	These results reveal the diverse changes in HRGP-related processes that occur during wood formation at the gene expression and HRGP glycan biosynthesis levels, and relate HRGPs and glycosylation processes to the developmental processes of wood formation.	Polysaccharides	132-138	histidine rich glycoprotein	Homo sapiens	127-131
33310702-0	2021	Fc gamma receptor IIIa / CD16a processing correlates with the expression of glycan-related genes in human natural killer cells.	Polysaccharides	76-82	Fc gamma receptor IIIa	Homo sapiens	0-22
33315098-8	2022	CONCLUSIONS: In IgA nephropathy, the severity of the disease is associated with the level of IgA exposing N-Acetyl-D-Galactosamine, N-Acetyl-D-Glucosamine or mannose whereas C4d deposits are only associated with elevated levels of IgA1 glycoforms exhibiting glycan residues with specificity for mannose and N-Acetyl-D-Glucosamine binding lectins.	Polysaccharides	258-264	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	16-19
33315098-8	2022	CONCLUSIONS: In IgA nephropathy, the severity of the disease is associated with the level of IgA exposing N-Acetyl-D-Galactosamine, N-Acetyl-D-Glucosamine or mannose whereas C4d deposits are only associated with elevated levels of IgA1 glycoforms exhibiting glycan residues with specificity for mannose and N-Acetyl-D-Glucosamine binding lectins.	Polysaccharides	258-264	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	93-96
33004438-2	2020	Additional modification of the glycan core by alpha-1,6-fucose addition to the innermost GlcNAc residue (core fucosylation) is catalyzed by an alpha-1,6-fucosyltransferase (FUT8).	Polysaccharides	31-37	fucosyltransferase 8	Homo sapiens	143-171
33004438-2	2020	Additional modification of the glycan core by alpha-1,6-fucose addition to the innermost GlcNAc residue (core fucosylation) is catalyzed by an alpha-1,6-fucosyltransferase (FUT8).	Polysaccharides	31-37	fucosyltransferase 8	Homo sapiens	173-177
33004438-6	2020	Here, using various crystal structures of FUT8 in complex with a donor substrate analog, and with four distinct glycan acceptors, we identify the molecular basis for FUT8 specificity and activity.	Polysaccharides	112-118	fucosyltransferase 8	Homo sapiens	166-170
33310702-0	2021	Fc gamma receptor IIIa / CD16a processing correlates with the expression of glycan-related genes in human natural killer cells.	Polysaccharides	76-82	Fc gamma receptor IIIa	Homo sapiens	25-30
33310702-3	2021	CD16a is heavily processed and recent reports indicate that the composition of the five CD16a asparagine(N)-linked carbohydrates (glycans) impacts affinity.	Polysaccharides	130-137	Fc gamma receptor IIIa	Homo sapiens	0-5
33310702-3	2021	CD16a is heavily processed and recent reports indicate that the composition of the five CD16a asparagine(N)-linked carbohydrates (glycans) impacts affinity.	Polysaccharides	130-137	Fc gamma receptor IIIa	Homo sapiens	88-93
33310702-7	2021	Gene expression profiling by RNAseq and qRT-PCR revealed expression levels for glycan-modifying genes which correlated with CD16a glycan composition.	Polysaccharides	79-85	Fc gamma receptor IIIa	Homo sapiens	124-129
33310702-7	2021	Gene expression profiling by RNAseq and qRT-PCR revealed expression levels for glycan-modifying genes which correlated with CD16a glycan composition.	Polysaccharides	130-136	Fc gamma receptor IIIa	Homo sapiens	124-129
33310702-9	2021	N-glycan processing correlated with the expression of glycan modifying genes and thus explained the substantial differences in CD16a processing by NK cells of different origins.	Polysaccharides	2-8	Fc gamma receptor IIIa	Homo sapiens	127-132
32248235-3	2020	Here we report the detection of these glycans on glycoproteins as well as in their free forms via enzymatic incorporation of fluorophore-conjugated fucose using FUT2, FUT6, FUT7, and FUT8 and FUT9.	Polysaccharides	38-45	galactoside alpha-(1,2)-fucosyltransferase 2	Bos taurus	161-165
33295603-4	2021	Some of these limitations stem from the difficulty to track the biosynthetic process of mucin-type O-glycosylation, especially when glycans occur in dense clusters in repeat regions of proteins, such as the mucins or IgA1.	Polysaccharides	132-139	LOC100508689	Homo sapiens	88-93
33295603-4	2021	Some of these limitations stem from the difficulty to track the biosynthetic process of mucin-type O-glycosylation, especially when glycans occur in dense clusters in repeat regions of proteins, such as the mucins or IgA1.	Polysaccharides	132-139	immunoglobulin heavy constant alpha 1	Homo sapiens	217-221
33226212-0	2020	Recovery of Ggt7 and Ace Expressions in the Colon Alleviates Collagen-Induced Arthritis in Rats by Specific Bioactive Polysaccharide Intervention.	Polysaccharides	118-132	gamma-glutamyltransferase 7	Rattus norvegicus	12-16
32248235-3	2020	Here we report the detection of these glycans on glycoproteins as well as in their free forms via enzymatic incorporation of fluorophore-conjugated fucose using FUT2, FUT6, FUT7, and FUT8 and FUT9.	Polysaccharides	38-45	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3	Bos taurus	167-171
33226212-0	2020	Recovery of Ggt7 and Ace Expressions in the Colon Alleviates Collagen-Induced Arthritis in Rats by Specific Bioactive Polysaccharide Intervention.	Polysaccharides	118-132	angiotensin I converting enzyme	Rattus norvegicus	21-24
32248235-3	2020	Here we report the detection of these glycans on glycoproteins as well as in their free forms via enzymatic incorporation of fluorophore-conjugated fucose using FUT2, FUT6, FUT7, and FUT8 and FUT9.	Polysaccharides	38-45	fucosyltransferase 7	Bos taurus	173-177
32248235-3	2020	Here we report the detection of these glycans on glycoproteins as well as in their free forms via enzymatic incorporation of fluorophore-conjugated fucose using FUT2, FUT6, FUT7, and FUT8 and FUT9.	Polysaccharides	38-45	fucosyltransferase 8	Bos taurus	183-187
32248235-3	2020	Here we report the detection of these glycans on glycoproteins as well as in their free forms via enzymatic incorporation of fluorophore-conjugated fucose using FUT2, FUT6, FUT7, and FUT8 and FUT9.	Polysaccharides	38-45	fucosyltransferase 9	Bos taurus	192-196
32363391-8	2020	The elucidation of the glycan repertoire on the spike protein provides insights into the viral binding studies and more importantly, propels research toward the development of a suitable vaccine candidate.	Polysaccharides	23-29	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	48-53
33363462-0	2020	Polysaccharide of Atractylodes macrocephala Koidz (PAMK) Alleviates Cyclophosphamide-induced Immunosuppression in Mice by Upregulating CD28/IP3R/PLCgamma-1/AP-1/NFAT Signal Pathway.	Polysaccharides	0-14	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	140-144
33312564-5	2020	As HBV hijacks DC subsets and viral antigens harbour glycan motifs, we hypothesised that HBV may subvert DCs through CLR binding.	Polysaccharides	53-59	doublecortin like kinase 3	Homo sapiens	117-120
33231438-2	2020	Prototypic galectins such as human galectin-7 (GAL-7) are characterized by their ability to form homodimers that control the molecular fate of a cell by mediating subtle yet critical glycan-dependent interactions between pro- and anti-apoptotic molecular partners.	Polysaccharides	183-189	galectin 7	Homo sapiens	35-45
33231438-2	2020	Prototypic galectins such as human galectin-7 (GAL-7) are characterized by their ability to form homodimers that control the molecular fate of a cell by mediating subtle yet critical glycan-dependent interactions between pro- and anti-apoptotic molecular partners.	Polysaccharides	183-189	galectin 7	Homo sapiens	47-52
33363462-0	2020	Polysaccharide of Atractylodes macrocephala Koidz (PAMK) Alleviates Cyclophosphamide-induced Immunosuppression in Mice by Upregulating CD28/IP3R/PLCgamma-1/AP-1/NFAT Signal Pathway.	Polysaccharides	0-14	phospholipase C, gamma 1	Mus musculus	145-155
33363462-0	2020	Polysaccharide of Atractylodes macrocephala Koidz (PAMK) Alleviates Cyclophosphamide-induced Immunosuppression in Mice by Upregulating CD28/IP3R/PLCgamma-1/AP-1/NFAT Signal Pathway.	Polysaccharides	0-14	jun proto-oncogene	Mus musculus	156-160
33364945-10	2020	In conclusion, these findings confirmed that TP2, a capsular polysaccharide of B. fragilis, protects against ulcerative colitis in an undegraded form.	Polysaccharides	61-75	transition protein 2	Rattus norvegicus	45-48
33206527-10	2020	To investigate the regulatory effect of the N79 glycan on cellular growth, we mutated the single N-glycosylation site in CES1 from Asn to Gln (CES1-N79Q) via site-directed mutagenesis.	Polysaccharides	48-54	carboxylesterase 1	Homo sapiens	121-125
32978262-5	2020	This effect is more pronounced for ATZ than with AAT, and is only partially dependent on the glycan-binding site of CRT, which is generally relevant to substrate recruitment and folding by CRT.	Polysaccharides	93-99	serpin family A member 1	Homo sapiens	49-52
32978260-2	2020	alphaM protease inhibitors use theirs to conjugate proteases and preferentially react with primary amines (e.g. on lysine side chains), whereas those of alphaM complement components C3 and C4B have an increased hydroxyl reactivity that is conveyed by a conserved histidine residue and allows conjugation to cell surface glycans.	Polysaccharides	320-327	complement C4B (Chido blood group)	Homo sapiens	189-192
33273015-0	2021	Hyper-truncated Asn355- and Asn391-glycans modulate the activity of neutrophil granule myeloperoxidase.	Polysaccharides	35-42	myeloperoxidase	Homo sapiens	87-102
33229435-5	2021	Here we report the structures of human B3GNT2 in complex with UDP:Mg2+, and in complex with both UDP:Mg2+ and a glycan acceptor, lacto-N-neotetraose.	Polysaccharides	112-118	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	39-45
32978262-5	2020	This effect is more pronounced for ATZ than with AAT, and is only partially dependent on the glycan-binding site of CRT, which is generally relevant to substrate recruitment and folding by CRT.	Polysaccharides	93-99	calreticulin	Homo sapiens	116-119
32978262-5	2020	This effect is more pronounced for ATZ than with AAT, and is only partially dependent on the glycan-binding site of CRT, which is generally relevant to substrate recruitment and folding by CRT.	Polysaccharides	93-99	calreticulin	Homo sapiens	189-192
33273015-5	2021	Occlusion of the Asn355/Asn391-glycosylation sites and the Asn323-/Asn483-glycans, located in the MPO dimerisation zone, was found to affect the local glycan processing, thereby providing a molecular basis of the site-specific nMPO glycosylation.	Polysaccharides	74-81	myeloperoxidase	Homo sapiens	98-101
33273015-5	2021	Occlusion of the Asn355/Asn391-glycosylation sites and the Asn323-/Asn483-glycans, located in the MPO dimerisation zone, was found to affect the local glycan processing, thereby providing a molecular basis of the site-specific nMPO glycosylation.	Polysaccharides	74-80	myeloperoxidase	Homo sapiens	98-101
33273015-9	2021	While similar global MPO glycosylation was observed across conditions, the conserved Asn355-/Asn391-sites displayed elevated glycan hyper-truncation, which correlated with higher enzyme activities of MPO in distinct granule populations.	Polysaccharides	125-131	myeloperoxidase	Homo sapiens	200-203
33273015-10	2021	Enzymatic trimming of the Asn355-/Asn391-glycans recapitulated the activity gain and showed that nMPO carrying hyper-truncated glycans at these positions exhibits increased thermal stability, polypeptide accessibility, and ceruloplasmin-mediated inhibition potential relative to native nMPO.	Polysaccharides	127-134	ceruloplasmin	Homo sapiens	223-236
33273015-12	2021	Here, through an innovative and comprehensive approach, we report novel functional roles of MPO glycans, providing new insight into neutrophil-mediated immunity.	Polysaccharides	96-103	myeloperoxidase	Homo sapiens	92-95
32780906-6	2020	The dynamic process was further explored by extensive MD simulations, which provided additional support for the existence of allostery in glycan recognition by human galectin-1.	Polysaccharides	138-144	galectin 1	Homo sapiens	166-176
33130120-0	2020	Multiscale simulations examining glycan shield effects on drug binding to influenza neuraminidase.	Polysaccharides	33-39	neuraminidase 1	Homo sapiens	84-97
33130120-2	2020	Glycans are present on neuraminidase, and are generally considered to inhibit antibody binding via their glycan shield.	Polysaccharides	0-7	neuraminidase 1	Homo sapiens	23-36
33130120-3	2020	In this work we studied the effect of glycans on the binding kinetics of antiviral drugs to the influenza neuraminidase.	Polysaccharides	38-45	neuraminidase 1	Homo sapiens	106-119
33130120-4	2020	We created all-atom in silico systems of influenza neuraminidase with experimentally-derived glycoprofiles consisting of four systems with different glycan conformations and one system without glycans.	Polysaccharides	149-155	neuraminidase 1	Homo sapiens	51-64
33130120-4	2020	We created all-atom in silico systems of influenza neuraminidase with experimentally-derived glycoprofiles consisting of four systems with different glycan conformations and one system without glycans.	Polysaccharides	193-200	neuraminidase 1	Homo sapiens	51-64
33130120-5	2020	Using Brownian dynamics simulations, we observe a two- to eight-fold decrease in the rate of ligand binding to the primary binding site of neuraminidase due to the presence of glycans.	Polysaccharides	176-183	neuraminidase 1	Homo sapiens	139-152
33130120-6	2020	These glycans are capable of covering much of the surface area of neuraminidase, and the ligand binding inhibition is derived from glycans sterically occluding the primary binding site on a neighboring monomer.	Polysaccharides	6-13	neuraminidase 1	Homo sapiens	66-79
33130120-8	2020	These results help illuminate the complex interplay between glycans and ligand binding on the influenza membrane protein neuraminidase.	Polysaccharides	60-67	neuraminidase 1	Homo sapiens	121-134
32933681-1	2020	Fucoidan, a type of sulfated polysaccharide known for its anticoagulant, anti-tumor and anti-inflammatory effects, has been reported to have strong affinity towards P-selectin.	Polysaccharides	29-43	selectin P	Homo sapiens	165-175
32957164-0	2020	Mono- and Di-Fucosylated Glycans of the Parasitic Worm S. mansoni are Recognized Differently by the Innate Immune Receptor DC-SIGN.	Polysaccharides	25-32	CD209 molecule	Homo sapiens	123-130
32957164-1	2020	The parasitic worm,  Schistosoma mansoni,  expresses unusual fucosylated glycans  in a stage-dependent manner  that can be recognized by the human innate immune receptor DC-SIGN,  thereby shaping host immune responses .	Polysaccharides	73-80	CD209 molecule	Homo sapiens	170-177
32957164-4	2020	The molecular interaction between the synthetic glycans and DC-SIGN was studied by NMR and molecular modeling , which demonstrated that the alpha1,3-fucoside of LDN-F can coordinate with the Ca 2+ -ion of the canonical binding site of DC-SIGN allowing for additional interactions with the underlying LDN backbone.	Polysaccharides	48-55	CD209 molecule	Homo sapiens	60-67
32957164-4	2020	The molecular interaction between the synthetic glycans and DC-SIGN was studied by NMR and molecular modeling , which demonstrated that the alpha1,3-fucoside of LDN-F can coordinate with the Ca 2+ -ion of the canonical binding site of DC-SIGN allowing for additional interactions with the underlying LDN backbone.	Polysaccharides	48-55	CD209 molecule	Homo sapiens	235-242
33263330-8	2020	Furthermore, a third successful implementation of the GlycoDelete technology focusing on murine IL-12B is shown to lead to N-glycosylation featuring an immature glycan in diffraction-quality crystals.	Polysaccharides	161-167	interleukin 12b	Mus musculus	96-102
32858085-4	2020	METHODS: We prepared oligomannose-type glycan modified RNase (M9GN2-RNase) by chemoenzymatic means using M9GN-oxazoline and glycan truncated RNase B and analyzed the effect of human UGGT1 (HUGT1) for refolding of the denatured M9GN2-RNase.	Polysaccharides	39-45	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	182-187
32858085-4	2020	METHODS: We prepared oligomannose-type glycan modified RNase (M9GN2-RNase) by chemoenzymatic means using M9GN-oxazoline and glycan truncated RNase B and analyzed the effect of human UGGT1 (HUGT1) for refolding of the denatured M9GN2-RNase.	Polysaccharides	39-45	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	189-194
32858085-10	2020	CONCLUSIONS: HUGT1has the ability to promote the refolding of denatured protein and the effect would be enhanced when HUGT1 tightly interacts with the client protein via glycan recognition.	Polysaccharides	170-176	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	13-18
32858085-10	2020	CONCLUSIONS: HUGT1has the ability to promote the refolding of denatured protein and the effect would be enhanced when HUGT1 tightly interacts with the client protein via glycan recognition.	Polysaccharides	170-176	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	118-123
32780906-0	2020	Unravelling the Time Scale of Conformational Plasticity and Allostery in Glycan Recognition by Human Galectin-1.	Polysaccharides	73-79	galectin 1	Homo sapiens	101-111
32841667-2	2020	In this study, we isolated a polysaccharide fraction from P. americana herbal residue with the potential wound healing effect, named as PAP faction, based on our previous study and provided the structural and monosaccharide composition characterization.	Polysaccharides	29-43	regenerating family member 3 beta	Rattus norvegicus	136-139
33084194-1	2020	In this research work, a water-soluble polysaccharide (LAP) isolated from the fruits of Lycium arabicum was investigated.	Polysaccharides	39-53	LAP	Homo sapiens	55-58
33220676-1	2020	The water-soluble polysaccharide, SF-2, obtained from starfish (Asterias rollestoni), belongs to the group of polysaccharides known as mannoglucan sulfate.	Polysaccharides	18-32	serine and arginine-rich splicing factor 1	Mus musculus	34-38
33001366-5	2020	We hypothesize that glycan scaffold (MUC1"s tandem repeat peptide sequence) and/or multivalency play a role in the binding recognition of TF antigen by Gal-1.	Polysaccharides	20-26	mucin 1, cell surface associated	Homo sapiens	37-41
33001366-5	2020	We hypothesize that glycan scaffold (MUC1"s tandem repeat peptide sequence) and/or multivalency play a role in the binding recognition of TF antigen by Gal-1.	Polysaccharides	20-26	coagulation factor III, tissue factor	Homo sapiens	138-140
33001366-5	2020	We hypothesize that glycan scaffold (MUC1"s tandem repeat peptide sequence) and/or multivalency play a role in the binding recognition of TF antigen by Gal-1.	Polysaccharides	20-26	galectin 1	Homo sapiens	152-157
32918958-4	2020	RESULTS: LPS significantly increased the levels of LPO and LDH in RAW 264.7 cells which were significantly reduced in PS pre-treatment groups.	Polysaccharides	10-12	lactoperoxidase	Mus musculus	51-54
33346954-4	2020	This review is focused on the development of methodologies for preparing mucin-inspired synthetic oligomers and glycopolymers, including solid-phase synthesis, polymerization of glycosylated monomers, and post-polymerization grafting of glycans to polymer chains.	Polysaccharides	237-244	LOC100508689	Homo sapiens	73-78
32968619-3	2020	Potential mechanisms for division of metabolic labor in microbial communities consuming polysaccharides are 1) complementary differences in gene content, 2) alternate regulation of polysaccharide degradation genes, 3) subtle differences in hydrolytic enzyme functionality, and 4) specialization in transport and consumption of hydrolysis products.	Polysaccharides	88-103	VPS52 subunit of GARP complex	Homo sapiens	104-109
32968619-3	2020	Potential mechanisms for division of metabolic labor in microbial communities consuming polysaccharides are 1) complementary differences in gene content, 2) alternate regulation of polysaccharide degradation genes, 3) subtle differences in hydrolytic enzyme functionality, and 4) specialization in transport and consumption of hydrolysis products.	Polysaccharides	88-102	VPS52 subunit of GARP complex	Homo sapiens	104-109
32308054-0	2020	Novel nano-pomegranates based on astragalus polysaccharides for targeting ERalpha-positive breast cancer and multidrug resistance.	Polysaccharides	44-59	estrogen receptor 1	Homo sapiens	74-81
33388127-2	2020	The discovery of different broadly neutralizing antibodies (bnAbs) in the last decades has enabled the characterization of several minimal epitopes on the HIV envelope (Env) spike, including glycan-dependent fragments.	Polysaccharides	191-197	endogenous retrovirus group K member 20	Homo sapiens	169-172
33258347-11	2020	CONCLUSION: Our findings suggest that C. paliurus polysaccharides may play a protecting role for nephropathy of diabetic rats by lowering glucose, creatinine, urea, uric acid level, enhancing the antioxidative ability, and reducing AGEs and TGF-beta1 expression.	Polysaccharides	50-65	transforming growth factor, beta 1	Rattus norvegicus	241-250
32707285-5	2020	We also reviewed dietary components known to have modulative effects on MUC2 mucin expression, such as polysaccharides, amino acids and polyphenols.	Polysaccharides	103-118	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	72-76
32926903-0	2020	Immunomodulatory mechanism of a purified polysaccharide isolated from Isaria cicadae Miquel on RAW264.7 cells via activating TLR4-MAPK-NF-kappaB signaling pathway.	Polysaccharides	41-55	toll-like receptor 4	Mus musculus	125-129
32926903-0	2020	Immunomodulatory mechanism of a purified polysaccharide isolated from Isaria cicadae Miquel on RAW264.7 cells via activating TLR4-MAPK-NF-kappaB signaling pathway.	Polysaccharides	41-55	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	135-144
32750476-1	2020	Natural polysaccharides have been investigated as vehicles for oral insulin administration.	Polysaccharides	8-23	insulin	Homo sapiens	68-75
32755704-2	2020	The aim of this study was to investigate the effects of polysaccharide from the seeds of Plantago asiatica L. (PLP) on nonylphenol (NP) induced intestinal barrier injury in vitro.	Polysaccharides	56-70	proteolipid protein 1	Homo sapiens	111-114
33510604-5	2020	GALE function extends to the biosynthesis of glycans by epimerization of UDP-N-acetyl-galactosamine and -glucosamine.	Polysaccharides	45-52	UDP-galactose-4-epimerase	Homo sapiens	0-4
32404945-4	2020	Proteins involved in both excitatory and inhibitory neurotransmission display altered glycans in the disease state, including AMPA and kainate receptor subunits, glutamate transporters EAAT1 and EAAT2, and the GABAA receptor.	Polysaccharides	86-93	solute carrier family 1 member 2	Homo sapiens	195-200
32748397-1	2020	Toll-like receptors (TLRs), TLR2 in particular, are shown to recognize various glycans and glycolipid ligands resulting in various immune effector functions.	Polysaccharides	79-86	toll-like receptor 2	Mus musculus	28-32
33242079-0	2021	Majority of alpha2,6-sialylated glycans in adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.	Polysaccharides	32-39	calmegin	Mus musculus	12-20
33324641-4	2020	This cell surface glycan modification of CD44 has previously shown in preclinical studies to favor trafficking of mAdMSCs to inflamed or injured peripheral tissues.	Polysaccharides	18-24	CD44 antigen	Mus musculus	41-45
33324681-4	2020	While GAG-PrP interactions had been previously reported, the specific glycan structures that facilitate interactions with different regions of PrP and their binding kinetics have not been systematically investigated.	Polysaccharides	70-76	prion protein	Mus musculus	143-146
33256188-5	2020	The eliciting activity of these sulfated polysaccharides in stimulating the natural defenses of the date palm was evaluated through the activity of phenylalanine ammonia-lyase (PAL), and the increase in phenols and lignin content in the roots.	Polysaccharides	41-56	phenylalanine ammonia-lyase	Phoenix dactylifera	148-175
33256188-5	2020	The eliciting activity of these sulfated polysaccharides in stimulating the natural defenses of the date palm was evaluated through the activity of phenylalanine ammonia-lyase (PAL), and the increase in phenols and lignin content in the roots.	Polysaccharides	41-56	phenylalanine ammonia-lyase	Phoenix dactylifera	177-180
33242079-8	2021	Consequently, alpha2,6-sialylated N-glycans were scarcely detected in adult mouse brain tissues, and majority of alpha2,6-sialylated glycans found in mouse brain were O-linked glycans.	Polysaccharides	36-43	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	14-20
33219282-4	2020	A most important finding was that GlcA activity requires the prior removal of the stem peptide by AmiA for its activity thus the naked glycan strand is its substrate.	Polysaccharides	135-141	AT695_RS13185	Staphylococcus aureus	98-102
33319171-4	2020	This is the first complete all-atom model of HIV-1 Env SOSIP glycan shield that includes both oligomannose and complex glycans, providing physiologically relevant insights of the glycan shield.	Polysaccharides	61-67	endogenous retrovirus group K member 20	Homo sapiens	51-54
32928962-3	2020	The glycans on lubricin have also been suggested to be involved in crosslinking and stabilization of the lubricating superficial layer of cartilage by mediating interaction between lubricin and galectin-3.	Polysaccharides	4-11	proteoglycan 4	Homo sapiens	15-23
32928962-3	2020	The glycans on lubricin have also been suggested to be involved in crosslinking and stabilization of the lubricating superficial layer of cartilage by mediating interaction between lubricin and galectin-3.	Polysaccharides	4-11	proteoglycan 4	Homo sapiens	181-189
33319171-4	2020	This is the first complete all-atom model of HIV-1 Env SOSIP glycan shield that includes both oligomannose and complex glycans, providing physiologically relevant insights of the glycan shield.	Polysaccharides	119-126	endogenous retrovirus group K member 20	Homo sapiens	51-54
32928962-3	2020	The glycans on lubricin have also been suggested to be involved in crosslinking and stabilization of the lubricating superficial layer of cartilage by mediating interaction between lubricin and galectin-3.	Polysaccharides	4-11	galectin-3	Cricetulus griseus	194-204
33319171-4	2020	This is the first complete all-atom model of HIV-1 Env SOSIP glycan shield that includes both oligomannose and complex glycans, providing physiologically relevant insights of the glycan shield.	Polysaccharides	119-125	endogenous retrovirus group K member 20	Homo sapiens	51-54
32928962-4	2020	However, with the spectrum of glycans being found on lubricin, the glycan candidates involved in this interaction were unknown.	Polysaccharides	30-37	proteoglycan 4	Homo sapiens	53-61
32928962-4	2020	However, with the spectrum of glycans being found on lubricin, the glycan candidates involved in this interaction were unknown.	Polysaccharides	30-36	proteoglycan 4	Homo sapiens	53-61
32619666-1	2020	Three water-soluble polysaccharides (AMAP-1, AMAP-2 and AMAP-3) were isolated and purified from Atractylodis Macrocephalae Rhizoma by using the combination of ion-exchange chromatography and gel permeation chromatography.	Polysaccharides	20-35	MYCBP associated protein	Mus musculus	37-43
33147005-0	2020	Reversing P-Glycoprotein-Associated Multidrug Resistance of Breast Cancer by Targeted Acid-Cleavable Polysaccharide Nanoparticles with Lapatinib Sensitization.	Polysaccharides	101-115	ATP binding cassette subfamily B member 1	Homo sapiens	10-24
33203761-2	2020	We have recently shown that antibodies targeting O-specific polysaccharide (OSP) of Vibrio cholerae correlate highly with protection against cholera.	Polysaccharides	60-74	claudin 11	Homo sapiens	76-79
33203761-9	2020	Our findings suggest that the impedance of motility by antibodies targeting V. cholerae OSP contributes to protection against cholera.IMPORTANCE Cholera is a severe dehydrating illness of humans caused by Vibrio cholerae V. cholerae is a highly motile bacterium that has a single flagellum covered in lipopolysaccharide (LPS) displaying O-specific polysaccharide (OSP), and V. cholerae motility correlates with its ability to cause disease.	Polysaccharides	305-319	claudin 11	Homo sapiens	88-91
33141553-7	2020	In the present study, we provide comprehensive detail of compositional findings from mass spectrometry analyses of amino acid and glycan content of CLU purified from ATTRwt and control sera.	Polysaccharides	130-136	clusterin	Homo sapiens	148-151
32749019-2	2020	As Langerin has only low affinity for monovalent glycan ligands, highly multivalent presentation has previously been key for targeting.	Polysaccharides	49-55	CD207 molecule	Homo sapiens	3-11
32535321-0	2020	Immunomodulatory activity of a novel polysaccharide extracted from Huangshui on THP-1 cells through NO production and increased IL-6 and TNF-alpha expression.	Polysaccharides	37-51	interleukin 6	Homo sapiens	128-132
32535321-0	2020	Immunomodulatory activity of a novel polysaccharide extracted from Huangshui on THP-1 cells through NO production and increased IL-6 and TNF-alpha expression.	Polysaccharides	37-51	tumor necrosis factor	Homo sapiens	137-146
32621930-0	2020	A novel polysaccharide from Acorus tatarinowii protects against LPS-induced neuroinflammation and neurotoxicity by inhibiting TLR4-mediated MyD88/NF-kappaB and PI3K/Akt signaling pathways.	Polysaccharides	8-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	146-155
32629056-0	2020	Characterization of a polysaccharide from Sanghuangporus vaninii and its antitumor regulation via activation of the p53 signaling pathway in breast cancer MCF-7 cells.	Polysaccharides	22-36	tumor protein p53	Homo sapiens	116-119
32941900-3	2020	Among the four polysaccharides, CSPu showed the highest inhibitory alpha-glucosidase activity, which might be related to its smaller molecular weight.	Polysaccharides	15-30	sucrase-isomaltase	Homo sapiens	67-84
32979436-3	2020	In the current study, a series of polysaccharides from Saccharina japonica were prepared to investigate the structure-activity relationship on the binding abilities of polysaccharides (oligosaccharides) to pseudotype particles, including SARS-CoV-2 SGPs, and ACE2 using surface plasmon resonance.	Polysaccharides	168-183	angiotensin converting enzyme 2	Homo sapiens	259-263
33093196-0	2020	Visualization of the HIV-1 Env glycan shield across scales.	Polysaccharides	31-37	endogenous retrovirus group K member 20	Homo sapiens	27-30
33057580-0	2020	Identification of a glycan cluster in gp120 essential for irreversible HIV-1 lytic inactivation by a lectin-based recombinantly engineered protein conjugate.	Polysaccharides	20-26	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	38-43
33057580-4	2020	The relatively simplified engagement pattern of MVN with Env opened up the opportunity, pursued here, to use recombinant glycan-knockout gp120 variants to identify the precise Env binding site for MVN that drives DLI engagement and lysis.	Polysaccharides	121-127	endogenous retrovirus group K member 20	Homo sapiens	57-60
33057580-4	2020	The relatively simplified engagement pattern of MVN with Env opened up the opportunity, pursued here, to use recombinant glycan-knockout gp120 variants to identify the precise Env binding site for MVN that drives DLI engagement and lysis.	Polysaccharides	121-127	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	137-142
33057580-4	2020	The relatively simplified engagement pattern of MVN with Env opened up the opportunity, pursued here, to use recombinant glycan-knockout gp120 variants to identify the precise Env binding site for MVN that drives DLI engagement and lysis.	Polysaccharides	121-127	endogenous retrovirus group K member 20	Homo sapiens	176-179
32913123-8	2020	To investigate the effects of TSR glycosylation on ADAMTSL2 function, we used mass spectrometry to identify glycan modifications at predicted consensus sequences on mouse ADAMTSL2.	Polysaccharides	108-114	ADAMTS-like 2	Mus musculus	171-179
33165704-12	2020	(B) Schematic diagram of electrode construction for detecting alpha2,6-sialylated glycans (alpha2,6-sial-Gs).	Polysaccharides	82-89	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	62-70
33165704-12	2020	(B) Schematic diagram of electrode construction for detecting alpha2,6-sialylated glycans (alpha2,6-sial-Gs).	Polysaccharides	82-89	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	91-99
33172133-3	2020	The results from monosaccharide analysis indicated that PAP-1, PAP-2, PAP-3 were acidic polysaccharides and PAP-4 was a neutral polysaccharide.	Polysaccharides	88-103	regenerating family member 3 alpha	Homo sapiens	56-61
33172133-3	2020	The results from monosaccharide analysis indicated that PAP-1, PAP-2, PAP-3 were acidic polysaccharides and PAP-4 was a neutral polysaccharide.	Polysaccharides	88-102	regenerating family member 3 alpha	Homo sapiens	56-61
33172133-8	2020	PAP-1 exhibited relatively stronger antioxidant activities among the four polysaccharides in a dose-dependent manner.	Polysaccharides	74-89	regenerating family member 3 alpha	Homo sapiens	0-5
32987010-5	2020	The detailed fragmentation analysis performed by collision-induced dissociation (CID) tandem MS provided information of structural elements related to the glycan core and ceramide moiety, which confirmed the molecular configuration of GD3 (d18:1/24:1) and GD3 (d18:1/24:2) species with potential biomarker role.	Polysaccharides	155-161	GRDX	Homo sapiens	235-238
33093196-1	2020	The dense array of N-linked glycans on the HIV-1 envelope glycoprotein (Env), known as the "glycan shield," is a key determinant of immunogenicity, yet intrinsic heterogeneity confounds typical structure-function analysis.	Polysaccharides	28-34	endogenous retrovirus group K member 20	Homo sapiens	49-70
33093196-1	2020	The dense array of N-linked glycans on the HIV-1 envelope glycoprotein (Env), known as the "glycan shield," is a key determinant of immunogenicity, yet intrinsic heterogeneity confounds typical structure-function analysis.	Polysaccharides	28-34	endogenous retrovirus group K member 20	Homo sapiens	72-75
33093196-5	2020	Analysis of Env expressed in different cell lines revealed how cryo-EM can detect subtle changes in glycan occupancy, composition, and dynamics that impact glycan shield structure and epitope accessibility.	Polysaccharides	100-106	endogenous retrovirus group K member 20	Homo sapiens	12-15
33093196-5	2020	Analysis of Env expressed in different cell lines revealed how cryo-EM can detect subtle changes in glycan occupancy, composition, and dynamics that impact glycan shield structure and epitope accessibility.	Polysaccharides	156-162	endogenous retrovirus group K member 20	Homo sapiens	12-15
33093196-6	2020	Importantly, this identified unforeseen changes in the glycan shield of Env obtained from expression in the same cell line used for vaccine production.	Polysaccharides	55-61	endogenous retrovirus group K member 20	Homo sapiens	72-75
33312519-5	2020	Cereal-derived phenolic compounds, peptides, nonstarch polysaccharides, and lipids have been shown to inhibit alpha-amylase and alpha-glucosidase activities.	Polysaccharides	55-70	sucrase-isomaltase	Homo sapiens	128-145
33093196-7	2020	Finally, by capturing the enzymatic deglycosylation of Env in a time-resolved manner, we found that highly connected glycan clusters are resistant to digestion and help stabilize the prefusion trimer, suggesting the glycan shield may function beyond immune evasion.	Polysaccharides	117-123	endogenous retrovirus group K member 20	Homo sapiens	55-58
33093196-7	2020	Finally, by capturing the enzymatic deglycosylation of Env in a time-resolved manner, we found that highly connected glycan clusters are resistant to digestion and help stabilize the prefusion trimer, suggesting the glycan shield may function beyond immune evasion.	Polysaccharides	216-222	endogenous retrovirus group K member 20	Homo sapiens	55-58
33064451-0	2020	Comprehensive Analysis of the Glycan Complement of SARS-CoV-2 Spike Proteins Using Signature Ions-Triggered Electron-Transfer/Higher-Energy Collisional Dissociation (EThcD) Mass Spectrometry.	Polysaccharides	30-36	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	62-67
32659425-3	2020	Low concentrations of Cd2+ and montmorillonite or their combinations enhanced biofilm formation by increasing polysaccharides proportion in the biofilm matrix, and the maximum adsorption capacity of Cd2+ by biofilm was increased by 1.5 times.	Polysaccharides	110-125	CD2 molecule	Homo sapiens	22-25
33067390-0	2020	Mapping glycan-mediated galectin-3 interactions by live cell proximity labeling.	Polysaccharides	8-14	galectin 3	Homo sapiens	24-34
33067390-2	2020	While the requisite glycan epitopes needed to bind galectin-3 have long been elucidated, the cellular glycoproteins that bear these glycan signatures remain unknown.	Polysaccharides	20-26	galectin 3	Homo sapiens	51-61
33067390-5	2020	Understanding the identity of the glycoproteins and defining the structures of the glycans will empower efforts to design and develop selective therapeutics to mitigate galectin-3-mediated biological events.	Polysaccharides	83-90	galectin 3	Homo sapiens	169-179
33090801-2	2020	However, this barrier is constantly challenged by mucin-degrading enzymes, which tend to target anionic glycan chains such as sulfate groups and sialic acid residues.	Polysaccharides	104-110	LOC100508689	Homo sapiens	50-55
33090801-6	2020	Our results contribute to a better understanding on how different glycans contribute to the broad spectrum of functions mucin glycoproteins have.	Polysaccharides	66-73	LOC100508689	Homo sapiens	120-125
32659425-3	2020	Low concentrations of Cd2+ and montmorillonite or their combinations enhanced biofilm formation by increasing polysaccharides proportion in the biofilm matrix, and the maximum adsorption capacity of Cd2+ by biofilm was increased by 1.5 times.	Polysaccharides	110-125	CD2 molecule	Homo sapiens	199-202
32731916-4	2020	ECM is composed of diverse components including several proteins and polysaccharide chains such as chondroitin sulfate, heparan sulfate, and hyaluronic acid.	Polysaccharides	69-83	multimerin 1	Homo sapiens	0-3
32648516-1	2020	Cellulose, a polysaccharide of beta (1-4) linked D-glucose units, is a cheap, eco-friendly, and most abundant natural polymer on this planet.	Polysaccharides	13-27	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	31-40
33010330-9	2020	In addition, the opposite alterations of the afucosylated glycans with alpha2,3-linked sialic acid and those only with alpha2,6-linked sialic acid were observed at old age in male mice.	Polysaccharides	58-65	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	71-79
32594109-6	2020	Glycan structures in the purified prothrombin containing PIVKA-II were qualitatively analyzed by high performance liquid chromatography after labeling the glycan with fluorophore 2-aminobenzamide.	Polysaccharides	0-6	coagulation factor II, thrombin	Homo sapiens	34-45
33110150-3	2020	In addition, ABO(H) structures are also present on VWF glycans.	Polysaccharides	55-62	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	13-16
33106676-4	2020	Beyond the mucin-type O-glycopeptides discussed here, O-Pair Search also accepts user-defined glycan databases, making it compatible with many types of O-glycosylation.	Polysaccharides	94-100	LOC100508689	Homo sapiens	11-16
32697003-3	2020	Previously we identified alpha-fucose as a glycan that was expressed in high levels on cells of GGTA1/CMAH KO pigs.	Polysaccharides	43-49	N-acetyllactosaminide alpha-1,3-galactosyltransferase	Sus scrofa	96-101
32697003-3	2020	Previously we identified alpha-fucose as a glycan that was expressed in high levels on cells of GGTA1/CMAH KO pigs.	Polysaccharides	43-49	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Sus scrofa	102-106
33312537-0	2020	Hepatoprotective effect of crude polysaccharide isolated from Lycium barbarum L. against alcohol-induced oxidative damage involves Nrf2 signaling.	Polysaccharides	33-47	NFE2 like bZIP transcription factor 2	Homo sapiens	131-135
33140034-3	2020	Similar to many other viral fusion proteins, the SARS-CoV-2 spike utilizes a glycan shield to thwart the host immune response.	Polysaccharides	77-83	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	60-65
33140034-7	2020	This finding is corroborated by biolayer interferometry experiments, which show that deletion of these glycans through N165A and N234A mutations significantly reduces binding to ACE2 as a result of the RBD conformational shift toward the "down" state.	Polysaccharides	103-110	angiotensin converting enzyme 2	Homo sapiens	178-182
33140034-8	2020	Additionally, end-to-end accessibility analyses outline a complete overview of the vulnerabilities of the glycan shield of the SARS-CoV-2 S protein, which may be exploited in the therapeutic efforts targeting this molecular machine.	Polysaccharides	106-112	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	127-128
33140034-9	2020	Overall, this work presents hitherto unseen functional and structural insights into the SARS-CoV-2 S protein and its glycan coat, providing a strategy to control the conformational plasticity of the RBD that could be harnessed for vaccine development.	Polysaccharides	117-123	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	88-89
33120897-2	2020	It has shown that polysaccharide extracted from Codium fragile (CFP) induces anti-cancer immunity by dendritic cell (DC) activation, while the effect of CFP has not examined in the human immune cells.	Polysaccharides	18-32	complement factor properdin	Homo sapiens	64-67
32926485-9	2020	This supports the hypothesis that DAVEI"s engage Env at both glycans and the Env MPER in causing membrane poration and lysis.	Polysaccharides	61-68	endogenous retrovirus group K member 20	Homo sapiens	49-52
33124956-0	2022	Glycan-mediated functional assembly of IL-1RI: structural insights into completion of the current description for immune response.	Polysaccharides	0-6	interleukin 1 receptor type 1	Homo sapiens	39-45
33124956-7	2022	Simulations showed that the "compact" and "extended" IL-1RI form two types of "cytokine-inaccessible-non-signaling" and "cytokine-accessible-signaling" assemblies with the IL-1RacP, respectively that are both abiding in the presence of glycans.	Polysaccharides	236-243	interleukin 1 receptor type 1	Homo sapiens	53-59
33124956-7	2022	Simulations showed that the "compact" and "extended" IL-1RI form two types of "cytokine-inaccessible-non-signaling" and "cytokine-accessible-signaling" assemblies with the IL-1RacP, respectively that are both abiding in the presence of glycans.	Polysaccharides	236-243	interleukin 1 receptor accessory protein	Homo sapiens	172-180
33124956-9	2022	The "extended" complex is maintained by formation of several persistent hydrogen bonds between the IL-1RI-IL-1RAcP inter-connected glycans.	Polysaccharides	131-138	interleukin 1 receptor type 1	Homo sapiens	99-105
33124956-9	2022	The "extended" complex is maintained by formation of several persistent hydrogen bonds between the IL-1RI-IL-1RAcP inter-connected glycans.	Polysaccharides	131-138	interleukin 1 receptor accessory protein	Homo sapiens	106-114
33140034-0	2020	Beyond Shielding: The Roles of Glycans in the SARS-CoV-2 Spike Protein.	Polysaccharides	31-38	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	57-62
33110150-3	2020	In addition, ABO(H) structures are also present on VWF glycans.	Polysaccharides	55-62	von Willebrand factor	Homo sapiens	51-54
32280962-0	2020	Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand.	Polysaccharides	0-6	galectin 1	Homo sapiens	95-105
32280962-3	2020	We carried out glycomic and glycoproteomic studies to characterize the glycan composition of PSG1 purified from serum of pregnant women and identified the presence of complex N-glycans containing poly LacNAc epitopes with alpha2,3 sialyation at four sites.	Polysaccharides	71-77	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	93-97
33205023-0	2020	Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by Antibodies.	Polysaccharides	0-6	endogenous retrovirus group K member 20	Homo sapiens	33-36
33021613-0	2020	A polysaccharide extracted from alfalfa activates splenic B cells by TLR4 and acts primarily via the MAPK/p38 pathway.	Polysaccharides	2-16	toll-like receptor 4	Mus musculus	69-73
33084569-3	2020	Here, we report on a monoclonal antibody, Ab1485, isolated from a macaque infected with SHIVAD8 that developed broadly neutralizing serologic activity targeting the V3-glycan region of HIV-1 Env.	Polysaccharides	168-174	endogenous retrovirus group K member 20	Homo sapiens	191-194
33084569-6	2020	A 3.5 A cryo-electron microscopy structure of Ab1485 in complex with a native-like SOSIP Env trimer showed conserved contacts with the N332gp120 glycan and gp120 GDIR peptide motif, but in a distinct Env-binding orientation relative to human V3/N332gp120 glycan-targeting bNAbs.	Polysaccharides	145-151	endogenous retrovirus group K member 20	Homo sapiens	89-92
33084569-6	2020	A 3.5 A cryo-electron microscopy structure of Ab1485 in complex with a native-like SOSIP Env trimer showed conserved contacts with the N332gp120 glycan and gp120 GDIR peptide motif, but in a distinct Env-binding orientation relative to human V3/N332gp120 glycan-targeting bNAbs.	Polysaccharides	255-261	endogenous retrovirus group K member 20	Homo sapiens	89-92
33205023-0	2020	Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by Antibodies.	Polysaccharides	37-43	endogenous retrovirus group K member 20	Homo sapiens	33-36
33205023-4	2020	Specifically, the N262 glycan, although not in the CD4-binding site, modulated Env binding to the CD4 receptor, affected Env recognition by several glycan-dependent neutralizing antibodies, and altered site-specific glycosylation heterogeneity, with, for example, N448 displaying limited glycan processing.	Polysaccharides	148-154	endogenous retrovirus group K member 20	Homo sapiens	121-124
33205023-4	2020	Specifically, the N262 glycan, although not in the CD4-binding site, modulated Env binding to the CD4 receptor, affected Env recognition by several glycan-dependent neutralizing antibodies, and altered site-specific glycosylation heterogeneity, with, for example, N448 displaying limited glycan processing.	Polysaccharides	148-154	endogenous retrovirus group K member 20	Homo sapiens	121-124
33205023-6	2020	This study demonstrates how changes in individual glycans can alter molecular dynamics, processing, and function of the Env-glycan shield.	Polysaccharides	50-57	endogenous retrovirus group K member 20	Homo sapiens	120-123
33205023-6	2020	This study demonstrates how changes in individual glycans can alter molecular dynamics, processing, and function of the Env-glycan shield.	Polysaccharides	50-56	endogenous retrovirus group K member 20	Homo sapiens	120-123
33205023-2	2020	How each glycan interacts to shape the Env-protein-sugar complex and affects Env function is not well understood.	Polysaccharides	9-15	endogenous retrovirus group K member 20	Homo sapiens	39-42
33205023-2	2020	How each glycan interacts to shape the Env-protein-sugar complex and affects Env function is not well understood.	Polysaccharides	9-15	endogenous retrovirus group K member 20	Homo sapiens	77-80
33205023-3	2020	Here, analysis of two Env variants from the same donor, with differing functional characteristics and N-glycosylation-site composition, revealed that changes to key N-glycosylation sites affected the Env structure at distant locations and had a ripple effect on Env-wide glycan processing, virus infectivity, antibody recognition, and virus neutralization.	Polysaccharides	271-277	endogenous retrovirus group K member 20	Homo sapiens	22-25
33205023-3	2020	Here, analysis of two Env variants from the same donor, with differing functional characteristics and N-glycosylation-site composition, revealed that changes to key N-glycosylation sites affected the Env structure at distant locations and had a ripple effect on Env-wide glycan processing, virus infectivity, antibody recognition, and virus neutralization.	Polysaccharides	271-277	endogenous retrovirus group K member 20	Homo sapiens	200-203
33205023-3	2020	Here, analysis of two Env variants from the same donor, with differing functional characteristics and N-glycosylation-site composition, revealed that changes to key N-glycosylation sites affected the Env structure at distant locations and had a ripple effect on Env-wide glycan processing, virus infectivity, antibody recognition, and virus neutralization.	Polysaccharides	271-277	endogenous retrovirus group K member 20	Homo sapiens	200-203
33205023-4	2020	Specifically, the N262 glycan, although not in the CD4-binding site, modulated Env binding to the CD4 receptor, affected Env recognition by several glycan-dependent neutralizing antibodies, and altered site-specific glycosylation heterogeneity, with, for example, N448 displaying limited glycan processing.	Polysaccharides	23-29	endogenous retrovirus group K member 20	Homo sapiens	79-82
32800555-0	2020	Astragalus polysaccharide alleviates cognitive impairment and beta-amyloid accumulation in APP/PS1 mice via Nrf2 pathway.	Polysaccharides	11-25	presenilin 1	Mus musculus	95-98
33205023-4	2020	Specifically, the N262 glycan, although not in the CD4-binding site, modulated Env binding to the CD4 receptor, affected Env recognition by several glycan-dependent neutralizing antibodies, and altered site-specific glycosylation heterogeneity, with, for example, N448 displaying limited glycan processing.	Polysaccharides	23-29	CD4 molecule	Homo sapiens	98-110
32800555-0	2020	Astragalus polysaccharide alleviates cognitive impairment and beta-amyloid accumulation in APP/PS1 mice via Nrf2 pathway.	Polysaccharides	11-25	nuclear factor, erythroid derived 2, like 2	Mus musculus	108-112
33205023-4	2020	Specifically, the N262 glycan, although not in the CD4-binding site, modulated Env binding to the CD4 receptor, affected Env recognition by several glycan-dependent neutralizing antibodies, and altered site-specific glycosylation heterogeneity, with, for example, N448 displaying limited glycan processing.	Polysaccharides	23-29	endogenous retrovirus group K member 20	Homo sapiens	121-124
32817316-2	2020	Previously, we have demonstrated that the S-layer glycoprotein from probiotic Lactobacillus kefiri CIDCA 8348 (SLP-8348) is recognized by Mincle (macrophage inducible C-type lectin receptor) and its adjuvanticity depends on the integrity of its glycans.	Polysaccharides	245-252	superkiller viralicidic activity 2-like (S. cerevisiae), pseudogene 1	Mus musculus	111-114
32936606-2	2020	However, uncovering functional glycan ligands is challenging due to the large number of naturally occurring glycan structures, the limited availability of glycans in their purified form, the low affinities of GBP-glycan interactions, and limitations in existing binding assays.	Polysaccharides	31-37	transmembrane protein 132A	Homo sapiens	209-212
32747247-6	2020	The polysaccharides increased the TNF-alpha production in melanoma bearing mice with much higher intensity than in healthy mice.	Polysaccharides	4-19	tumor necrosis factor	Mus musculus	34-43
32534090-9	2020	Based on the measurements, it can be assumed that the dependence of the complex modulus on the polysaccharide concentration has a peak at the certain hyaluronan: albumin weight ratio.	Polysaccharides	95-109	albumin	Homo sapiens	162-169
32485257-4	2020	In total, 66 types of polysaccharides from 58 kinds of plant have shown hepatoprotective effect through the pathological process of inflammation, apoptosis and oxidative stress by regulating NF-kappaB, JAK/STAT, TGF-beta, PI3K/AKT, MAPK, caspase cascade, p53 and Nrf2-Keap1 pathways, lipid metabolism as well as cytochrome P450 enzymes.	Polysaccharides	22-37	transforming growth factor alpha	Homo sapiens	212-220
32485257-4	2020	In total, 66 types of polysaccharides from 58 kinds of plant have shown hepatoprotective effect through the pathological process of inflammation, apoptosis and oxidative stress by regulating NF-kappaB, JAK/STAT, TGF-beta, PI3K/AKT, MAPK, caspase cascade, p53 and Nrf2-Keap1 pathways, lipid metabolism as well as cytochrome P450 enzymes.	Polysaccharides	22-37	AKT serine/threonine kinase 1	Homo sapiens	227-230
32553949-3	2020	In this study, an acidic polysaccharide (PRP-2) was obtained from PR by ultrasonic assisted extraction and secondary column chromatography purification (Diethylaminoethyl cellulose-52 (DEAE-52) and Sephadex G-100).	Polysaccharides	25-39	transmembrane protein 171	Homo sapiens	41-46
32544584-1	2020	In this paper, a novel acidic polysaccharide (CPS-1) was successively prepared from Gynostemma pentaphyllum using hot water isolation method to explore its antitumor and antioxidant activities.	Polysaccharides	30-44	carbamoyl-phosphate synthase 1	Homo sapiens	46-51
32485257-4	2020	In total, 66 types of polysaccharides from 58 kinds of plant have shown hepatoprotective effect through the pathological process of inflammation, apoptosis and oxidative stress by regulating NF-kappaB, JAK/STAT, TGF-beta, PI3K/AKT, MAPK, caspase cascade, p53 and Nrf2-Keap1 pathways, lipid metabolism as well as cytochrome P450 enzymes.	Polysaccharides	22-37	tumor protein p53	Homo sapiens	255-258
32485257-4	2020	In total, 66 types of polysaccharides from 58 kinds of plant have shown hepatoprotective effect through the pathological process of inflammation, apoptosis and oxidative stress by regulating NF-kappaB, JAK/STAT, TGF-beta, PI3K/AKT, MAPK, caspase cascade, p53 and Nrf2-Keap1 pathways, lipid metabolism as well as cytochrome P450 enzymes.	Polysaccharides	22-37	NFE2 like bZIP transcription factor 2	Homo sapiens	263-267
32485257-4	2020	In total, 66 types of polysaccharides from 58 kinds of plant have shown hepatoprotective effect through the pathological process of inflammation, apoptosis and oxidative stress by regulating NF-kappaB, JAK/STAT, TGF-beta, PI3K/AKT, MAPK, caspase cascade, p53 and Nrf2-Keap1 pathways, lipid metabolism as well as cytochrome P450 enzymes.	Polysaccharides	22-37	kelch like ECH associated protein 1	Homo sapiens	268-273
32817216-7	2020	When immunized with gp150 complexed to BMS-529, rhesus macaques showed neutralization against tier 2 pseudoviruses with targeted glycan deletion and high mannose glycan enrichment.	Polysaccharides	129-135	integrin subunit beta 4	Homo sapiens	20-25
32791278-1	2020	Acylated chitosan sulfate (ChS1), a sulfated polysaccharide with high anticoagulant activity, was chemically synthesized and structurally characterized using FT-IR analysis.	Polysaccharides	45-59	lysosomal trafficking regulator	Homo sapiens	27-31
32931479-5	2020	Moreover, we describe a role for the glycan binding F-box protein Fbxo2 in CNS lysophagy.	Polysaccharides	37-43	F-box protein 2	Homo sapiens	66-71
33076454-6	2020	Furthermore, protein-specific glycan profiles were quantified for transferrin and IgG Fc using electrospray ionization MS of intact proteins and glycopeptides, respectively.	Polysaccharides	30-36	transferrin	Homo sapiens	66-77
32841772-4	2020	A method of Asymmetric Flow Field-Flow Fractionation (AF4) coupled with UV detection, multi-angle light scattering (MALS), and differential refractometer index (dRI) (AF4-UV-MALS-dRI) has been developed to analyse macromolecules, including tannins and polysaccharides, and macromolecular complexes, in red wine.	Polysaccharides	252-267	AF4/FMR2 family member 1	Homo sapiens	54-57
33066323-1	2020	Mannan (polysaccharide) conjugated with a myelin oligodendrocyte glycoprotein (MOG) peptide, namely (KG)5MOG35-55, represents a potent and promising new approach for the immunotherapy of Multiple Sclerosis (MS).	Polysaccharides	8-22	myelin oligodendrocyte glycoprotein	Mus musculus	42-77
33066323-1	2020	Mannan (polysaccharide) conjugated with a myelin oligodendrocyte glycoprotein (MOG) peptide, namely (KG)5MOG35-55, represents a potent and promising new approach for the immunotherapy of Multiple Sclerosis (MS).	Polysaccharides	8-22	myelin oligodendrocyte glycoprotein	Mus musculus	79-82
32841772-13	2020	Furthermore, our results have shown that AF4-UV-MALS-dRI could be an efficient technique to separate large size tannins as well as polysaccharides and macromolecular complexes.	Polysaccharides	131-146	AF4/FMR2 family member 1	Homo sapiens	41-44
32841772-4	2020	A method of Asymmetric Flow Field-Flow Fractionation (AF4) coupled with UV detection, multi-angle light scattering (MALS), and differential refractometer index (dRI) (AF4-UV-MALS-dRI) has been developed to analyse macromolecules, including tannins and polysaccharides, and macromolecular complexes, in red wine.	Polysaccharides	252-267	AF4/FMR2 family member 1	Homo sapiens	167-170
32817270-5	2020	We propose that the hinges allow S to scan the host cell surface, shielded from antibodies by an extensive glycan coat.	Polysaccharides	107-113	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	33-34
32729537-3	2020	This graphene device is functionalized with a carbohydrate recognition domain (CRD) of the human galectin-3 (hGal-3) protein to detect the presence of lactose from the donor effect of lectin - glycan affinity binding on the graphene.	Polysaccharides	193-199	galectin 3	Homo sapiens	97-107
32939912-5	2020	Significant binding to DC-SIGN was also found for azido-fucosylated glycans.	Polysaccharides	68-75	CD209 molecule	Homo sapiens	23-30
32841605-4	2020	Our results highlight roles for glycans in sterically masking polypeptide epitopes and directly modulating Spike-ACE2 interactions.	Polysaccharides	32-39	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	107-112
32841605-4	2020	Our results highlight roles for glycans in sterically masking polypeptide epitopes and directly modulating Spike-ACE2 interactions.	Polysaccharides	32-39	angiotensin converting enzyme 2	Homo sapiens	113-117
33116662-8	2020	Quantification of capsular polysaccharide confirmed that more capsule polysaccharide was produced by ampR+ and ampR-complementary strains compared to ampR- strains.	Polysaccharides	27-41	hypothetical protein	Klebsiella pneumoniae	101-105
33116662-8	2020	Quantification of capsular polysaccharide confirmed that more capsule polysaccharide was produced by ampR+ and ampR-complementary strains compared to ampR- strains.	Polysaccharides	27-41	hypothetical protein	Klebsiella pneumoniae	111-115
33116662-8	2020	Quantification of capsular polysaccharide confirmed that more capsule polysaccharide was produced by ampR+ and ampR-complementary strains compared to ampR- strains.	Polysaccharides	27-41	hypothetical protein	Klebsiella pneumoniae	111-115
33116662-8	2020	Quantification of capsular polysaccharide confirmed that more capsule polysaccharide was produced by ampR+ and ampR-complementary strains compared to ampR- strains.	Polysaccharides	70-84	hypothetical protein	Klebsiella pneumoniae	101-105
33116662-8	2020	Quantification of capsular polysaccharide confirmed that more capsule polysaccharide was produced by ampR+ and ampR-complementary strains compared to ampR- strains.	Polysaccharides	70-84	hypothetical protein	Klebsiella pneumoniae	111-115
33116662-8	2020	Quantification of capsular polysaccharide confirmed that more capsule polysaccharide was produced by ampR+ and ampR-complementary strains compared to ampR- strains.	Polysaccharides	70-84	hypothetical protein	Klebsiella pneumoniae	111-115
32729537-3	2020	This graphene device is functionalized with a carbohydrate recognition domain (CRD) of the human galectin-3 (hGal-3) protein to detect the presence of lactose from the donor effect of lectin - glycan affinity binding on the graphene.	Polysaccharides	193-199	galectin 3	Homo sapiens	109-115
32907757-1	2020	The many carbohydrate chains on Covid-19 coronavirus SARS-CoV-2 and its S-protein form a glycan-shield that masks antigenic peptides and decreases uptake of inactivated virus or S-protein vaccines by APC.	Polysaccharides	89-95	APC regulator of WNT signaling pathway	Homo sapiens	200-203
32738718-0	2020	The impact of structural modification of sulfated polysaccharides on bone morphogenic protein 2 and inhibition of endothelial cell angiogenesis.	Polysaccharides	50-65	bone morphogenetic protein 2	Homo sapiens	69-95
32738718-3	2020	In this study, binding between different sulfated polysaccharides and bone morphogenic protein 2 (BMP2) was measured to understand the sense of this motif transformation.	Polysaccharides	50-65	bone morphogenetic protein 2	Homo sapiens	70-96
32738718-3	2020	In this study, binding between different sulfated polysaccharides and bone morphogenic protein 2 (BMP2) was measured to understand the sense of this motif transformation.	Polysaccharides	50-65	bone morphogenetic protein 2	Homo sapiens	98-102
32738718-7	2020	DS that exceeded 1.05 impaired binding and played more important role in polysaccharide BMP2 interaction than MW.	Polysaccharides	73-87	bone morphogenetic protein 2	Homo sapiens	88-92
32738718-9	2020	Further, we showed that sulfated polysaccharides with strong binding to BMP2 blocked phosphorylation of Smad 1/5/8 and expression of Id1 to a greater extent than those not strongly bind to BMP2.	Polysaccharides	33-48	bone morphogenetic protein 2	Homo sapiens	72-76
32738718-9	2020	Further, we showed that sulfated polysaccharides with strong binding to BMP2 blocked phosphorylation of Smad 1/5/8 and expression of Id1 to a greater extent than those not strongly bind to BMP2.	Polysaccharides	33-48	SMAD family member 1	Homo sapiens	104-114
32738718-9	2020	Further, we showed that sulfated polysaccharides with strong binding to BMP2 blocked phosphorylation of Smad 1/5/8 and expression of Id1 to a greater extent than those not strongly bind to BMP2.	Polysaccharides	33-48	inhibitor of DNA binding 1, HLH protein	Homo sapiens	133-136
32738718-9	2020	Further, we showed that sulfated polysaccharides with strong binding to BMP2 blocked phosphorylation of Smad 1/5/8 and expression of Id1 to a greater extent than those not strongly bind to BMP2.	Polysaccharides	33-48	bone morphogenetic protein 2	Homo sapiens	189-193
32738718-10	2020	The binding strength of polysaccharides to BMP2 increased, so did the potency of the anti-angiogenesis effects.	Polysaccharides	24-39	bone morphogenetic protein 2	Homo sapiens	43-47
32818610-4	2020	Inspired by the CD44-mediated tumor targeting effect of the hydrophilic polysaccharide chondroitin sulphate (ChS), we chemically synthesized amphiphilic zein-ChS micelles.	Polysaccharides	72-86	CD44 molecule (Indian blood group)	Homo sapiens	16-20
33164434-0	2020	[Experimental study on improvement of alcoholic liver disease by polysaccharides from Balanophora henryi through targeting miR-122a].	Polysaccharides	65-80	microRNA 122	Mus musculus	123-131
33164434-1	2020	The aim of this paper was to investigate the effect of total polysaccharide from Balanophora henryi(TBP) on alcoholic liver disease(ALD) and explore the possible mechanism.	Polysaccharides	61-75	TATA box binding protein	Mus musculus	100-103
32767150-6	2020	Here, we investigate the glycan structures and possible functional differences of the two CGB variants.	Polysaccharides	25-31	chorionic gonadotropin subunit beta 5	Homo sapiens	90-93
33153880-1	2020	BACKGROUND: Polysaccharides decrease the glucose level by inhibiting alpha-glucosidase enzyme which further increases the level of GLP-1 (Glucagon-like peptide 1) to increase the insulin level as per earlier reports.	Polysaccharides	12-27	glucagon	Rattus norvegicus	131-136
33153880-1	2020	BACKGROUND: Polysaccharides decrease the glucose level by inhibiting alpha-glucosidase enzyme which further increases the level of GLP-1 (Glucagon-like peptide 1) to increase the insulin level as per earlier reports.	Polysaccharides	12-27	glucagon	Rattus norvegicus	138-161
32683071-2	2020	T antigen, a component of the MUC5AC glycans, is the product of the O-glycosylation transferase T-synthase and its chaperone Cosmc.	Polysaccharides	37-44	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	30-36
32683071-2	2020	T antigen, a component of the MUC5AC glycans, is the product of the O-glycosylation transferase T-synthase and its chaperone Cosmc.	Polysaccharides	37-44	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	96-106
32683071-2	2020	T antigen, a component of the MUC5AC glycans, is the product of the O-glycosylation transferase T-synthase and its chaperone Cosmc.	Polysaccharides	37-44	C1GALT1 specific chaperone 1	Homo sapiens	125-130
32987628-0	2020	Functions of Small Organic Compounds that Mimic the HNK-1 Glycan.	Polysaccharides	58-64	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	52-57
32830957-0	2020	Fluorescent Detection of O-GlcNAc via Tandem Glycan Labeling.	Polysaccharides	45-51	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	25-33
32610041-5	2020	We demonstrate the efficient utilization of such microscale glycopeptide libraries to determine the specificity of glycan-recognizing antibodies (e.g., CTD110.6) using microarrays, enzyme specificity on-array and in-solution (e.g., ST6GalNAc1, GCNT1, and T-synthase), and binding kinetics using fluorescence polarization.	Polysaccharides	115-121	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	Homo sapiens	232-242
32610041-5	2020	We demonstrate the efficient utilization of such microscale glycopeptide libraries to determine the specificity of glycan-recognizing antibodies (e.g., CTD110.6) using microarrays, enzyme specificity on-array and in-solution (e.g., ST6GalNAc1, GCNT1, and T-synthase), and binding kinetics using fluorescence polarization.	Polysaccharides	115-121	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	244-249
32610041-5	2020	We demonstrate the efficient utilization of such microscale glycopeptide libraries to determine the specificity of glycan-recognizing antibodies (e.g., CTD110.6) using microarrays, enzyme specificity on-array and in-solution (e.g., ST6GalNAc1, GCNT1, and T-synthase), and binding kinetics using fluorescence polarization.	Polysaccharides	115-121	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	255-265
32789497-7	2020	A combination of molecular docking, glycan grafting and molecular dynamics simulations predicts two distinct subsites for recognition of Lea and Lex trisaccharides.	Polysaccharides	36-42	fucosyltransferase 4	Mus musculus	145-148
32830957-3	2020	Here we report a highly efficient method for the identification of O-GlcNAc modification via tandem glycan labeling, in which O-GlcNAc is first galactosylated and then sialylated with a fluorophore-conjugated sialic acid residue, therefore enabling highly sensitive fluorescent detection.	Polysaccharides	100-106	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	67-75
32830957-3	2020	Here we report a highly efficient method for the identification of O-GlcNAc modification via tandem glycan labeling, in which O-GlcNAc is first galactosylated and then sialylated with a fluorophore-conjugated sialic acid residue, therefore enabling highly sensitive fluorescent detection.	Polysaccharides	100-106	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	126-134
32387604-0	2020	TRIF is essential for the anti-inflammatory effects of Astragalus polysaccharides on LPS-infected Caco2 cells.	Polysaccharides	66-81	TIR domain containing adaptor molecule 1	Homo sapiens	0-4
32938661-4	2020	Crystal structures of Env-bound and unbound antibodies revealed heavy chain-mediated recognition of the glycan supersite with a unique angle of approach and a critical role of the intra-HCDR3 disulfide.	Polysaccharides	104-110	endogenous retrovirus group K member 20	Homo sapiens	22-25
32938661-6	2020	Our findings further emphasize the V3 glycan supersite as a prominent target for Env-based vaccine design.	Polysaccharides	38-44	endogenous retrovirus group K member 20	Homo sapiens	81-84
32339574-4	2020	GPS-2 was a pectin-like polysaccharide consisting mainly of the homogalacturonan (HG) domain and a small amount of AG domain.	Polysaccharides	24-38	G protein pathway suppressor 2	Homo sapiens	0-5
32744401-3	2020	Cross-linking of Siglec-8 with monoclonal antibodies triggers apoptosis in eosinophils and inhibits degranulation of mast cells, making Siglec-8 a promising target for the treatment of eosinophil- and mast cell-associated diseases such as asthma.The tetrasaccharide 6"-sulfo-sialyl Lewisx(1a) has been identified as a specific Siglec-8 ligand in glycan array screening.	Polysaccharides	346-352	sialic acid binding Ig like lectin 8	Homo sapiens	17-25
32744401-3	2020	Cross-linking of Siglec-8 with monoclonal antibodies triggers apoptosis in eosinophils and inhibits degranulation of mast cells, making Siglec-8 a promising target for the treatment of eosinophil- and mast cell-associated diseases such as asthma.The tetrasaccharide 6"-sulfo-sialyl Lewisx(1a) has been identified as a specific Siglec-8 ligand in glycan array screening.	Polysaccharides	346-352	sialic acid binding Ig like lectin 8	Homo sapiens	136-144
32344342-2	2020	In this study, 1H NMR validated polyphenols and polysaccharides extracted from sprouted quinoa yoghurt were used as isolates and conjugates to upregulate the stimulation of GLP-1 release in NCI-H716 cells.	Polysaccharides	48-63	glucagon like peptide 1 receptor	Homo sapiens	173-178
32422265-2	2020	In the present work, an acid-soluble polysaccharide (GFAP) was prepared from Grifola frondosa under room temperature and hydrochloric acid solution treatment, and its inhibitory effects on H22 and HepG2 cells were investigated.	Polysaccharides	37-51	glial fibrillary acidic protein	Homo sapiens	53-57
32929138-0	2020	Analysis of the SARS-CoV-2 spike protein glycan shield reveals implications for immune recognition.	Polysaccharides	41-47	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	27-32
32669335-2	2020	Several mechanisms, such as the acquisition of mutations, variability of the loop length, and alterations in the glycan pattern, are employed by the virus to shield neutralizing epitopes on Env to sustain survival and infectivity within the host.	Polysaccharides	113-119	endogenous retrovirus group K member 20	Homo sapiens	190-193
32445816-2	2020	Within this study, the structural changes in hybrid polysaccharide chitosan/1,3-beta-D-glucan matrices cross-linked at 70  C and 80  C were detected with Attenuated Total Reflection Fourier Transform Infrared spectroscopy (ATR FT-IR) and Raman spectroscopy enabled thorough insights into molecular structure of studied biomaterials, whereas X-ray photoelectron spectroscopy (XPS) and atomic force microscopy (AFM) provided their surface characteristics with confirmation of their effective and non-destructive properties.	Polysaccharides	52-66	ATR serine/threonine kinase	Homo sapiens	223-226
32515841-1	2020	Heparin binds to and activates antithrombin (AT) through a specific pentasaccharide sequence in which a trisaccharide subsite, containing glucuronic acid (GlcA), has been considered as the initiator in the recognition of the polysaccharide by the protein.	Polysaccharides	225-239	serpin family C member 1	Homo sapiens	31-43
32828279-4	2020	Endo-CC N180H transferred the sialyl biantennary glycans from the sialylglyco peptide to pNP-GlcNAc and narigenin-7-O-glucoside.	Polysaccharides	49-56	mannosidase endo-alpha	Homo sapiens	0-4
32828279-7	2020	We proposed that the sialyl biantennary glycan transfer to the flavonoid by Endo-CC N180H could pave the way for the improvement of the inherent biological functions of the flavonoids and creation of novel flavonoid glycoside derivatives for future human health benefits including foods and drugs.	Polysaccharides	40-46	mannosidase endo-alpha	Homo sapiens	76-80
32900381-7	2020	For glycosphingolipids (GSLs), Globo H ceramide, an important tumor-associated GSL which is being actively investigated as a target for new cancer immunotherapies, will be used to demonstrate how glycan structure plays a significant role in enhancing angiogenesis in tumor microenvironments.	Polysaccharides	196-202	cathepsin A	Homo sapiens	24-27
32908216-4	2020	Although four of the 15 domains comprising CI-MPR"s extracellular region bind phosphorylated glycans on lysosomal enzymes, knowledge of how CI-MPR interacts with ~60 different lysosomal enzymes is limited.	Polysaccharides	93-100	insulin like growth factor 2 receptor	Homo sapiens	43-49
32894139-11	2020	CONCLUSIONS: In conclusion, we unravel a critical role of the NLRP3 inflammasome in Cg-induced pro-inflammatory cytokines production and colitis, which is an important discovery on the pro-inflammatory properties of this sulfated polysaccharide for pre-clinical studies.	Polysaccharides	230-244	NLR family, pyrin domain containing 3	Mus musculus	62-67
32675574-1	2020	PURPOSE OF REVIEW: The surface of the HIV-1 Env glycoprotein, the target of neutralizing antibodies, is extensively covered by N-linked glycans that create a glycan shield.	Polysaccharides	136-142	endogenous retrovirus group K member 20	Homo sapiens	44-47
32605924-0	2020	A polysaccharide extract from the medicinal plant Maidong inhibits the IKK-NF-kappaB pathway and IL-1beta-induced islet inflammation and increases insulin secretion.	Polysaccharides	2-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-84
32605924-0	2020	A polysaccharide extract from the medicinal plant Maidong inhibits the IKK-NF-kappaB pathway and IL-1beta-induced islet inflammation and increases insulin secretion.	Polysaccharides	2-16	interleukin 1 alpha	Mus musculus	97-105
32624579-0	2020	Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling.	Polysaccharides	22-28	galectin 3 binding protein	Homo sapiens	0-21
32624579-0	2020	Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling.	Polysaccharides	22-28	mechanistic target of rapamycin kinase	Homo sapiens	106-110
32899593-0	2020	Human Natural Antibodies Recognizing Glycan Galbeta1-3GlcNAc (LeC).	Polysaccharides	37-43	C-C motif chemokine ligand 16	Homo sapiens	62-65
32899593-7	2020	The enhanced interaction (instead of the expected inhibition) of antibodies with ZR 75-1 cells in the presence of Galbeta1-3GlcNAcbeta disaccharide, indicates that the target epitope of anti-LeC antibodies is a molecular pattern with a carbohydrate constituent rather than a glycan.	Polysaccharides	275-281	C-C motif chemokine ligand 16	Homo sapiens	191-194
32899783-6	2020	The highest activity of PEC, as well as the initial polysaccharides kappa-CGN and CH, was observed in a histamine-induced exudative inflammation, directly related to the activation of phagocytic cells, i.e., macrophages and neutrophils.	Polysaccharides	52-67	cingulin	Mus musculus	74-77
32944295-0	2020	Impact of glycan cloud on the B-cell epitope prediction of SARS-CoV-2 Spike protein.	Polysaccharides	10-16	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	70-75
32944295-7	2020	We identify 28 B-cell epitopes in the Spike structure and group them as non-affected by the glycan cloud versus those which are strongly masked by the glycan cloud, resulting in a list of favourable epitopes as targets for vaccine development, antibody-based therapy and diagnostics.	Polysaccharides	92-98	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	38-43
32944295-7	2020	We identify 28 B-cell epitopes in the Spike structure and group them as non-affected by the glycan cloud versus those which are strongly masked by the glycan cloud, resulting in a list of favourable epitopes as targets for vaccine development, antibody-based therapy and diagnostics.	Polysaccharides	151-157	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	38-43
32817557-4	2020	Here, we present a panel of bacterial proteases that cleave mucin domains via distinct peptide- and glycan-based motifs, generating a diverse enzymatic toolkit for mucin-selective proteolysis.	Polysaccharides	100-106	LOC100508689	Homo sapiens	60-65
32827942-7	2020	Examining cell-surface glycomes, IFNalpha increases levels of the immunosuppressive GalNAc-containing glycans (T/Tn antigens) on CD8+ T cells.	Polysaccharides	102-109	interferon alpha 1	Homo sapiens	33-41
32827942-7	2020	Examining cell-surface glycomes, IFNalpha increases levels of the immunosuppressive GalNAc-containing glycans (T/Tn antigens) on CD8+ T cells.	Polysaccharides	102-109	CD8a molecule	Homo sapiens	129-132
32782534-7	2020	In the present study, high-performance gel permeation chromatography, gas chromatography-mass spectrometry and nuclear magnetic resonance were used to identify the structure of polysaccharides from RF-1.	Polysaccharides	177-192	retroperitoneal fat pad weight 1	Mus musculus	198-202
32681961-3	2020	Hyaluronic acid (HA), a natural polysaccharide, is a specific ligand for CD44 that is overexpressed on the surface of activated macrophages.	Polysaccharides	32-46	CD44 molecule (Indian blood group)	Rattus norvegicus	73-77
32574379-5	2020	These findings are applicable to a parallel strategy for the generation of polysaccharides similar to those present in the receptor-binding domain of CoViD-19, which might inhibit viral adhesion to its receptor, the angiotensin-converting enzyme-2 (ACE2) protein, thereby impairing cellular uptake of the virus itself.	Polysaccharides	75-90	angiotensin converting enzyme 2	Homo sapiens	216-247
32574379-5	2020	These findings are applicable to a parallel strategy for the generation of polysaccharides similar to those present in the receptor-binding domain of CoViD-19, which might inhibit viral adhesion to its receptor, the angiotensin-converting enzyme-2 (ACE2) protein, thereby impairing cellular uptake of the virus itself.	Polysaccharides	75-90	angiotensin converting enzyme 2	Homo sapiens	249-253
32663509-3	2020	In the current study, knocking out sialyltransferase genes slightly enhanced the LacNAc content (>=4 repeats per glycan) on recombinant EPO protein.	Polysaccharides	113-119	erythropoietin	Homo sapiens	136-139
32663509-5	2020	While overexpression of B4GALT1 slightly enhanced the levels of large glycans on recombinant EPO, overexpression of B3GNT2 in EPO-expressing CHO cells significantly decreased the recombinant EPO LacNAc content, resulting in N-glycans terminating primarily with GlcNAc structures, a limited number of Gals, and nearly undetectable sialylation, which was also observed in sialyltransferases knock-out-B3GNT2 overexpression cell lines.	Polysaccharides	70-77	beta-1,4-galactosyltransferase 1	Cricetulus griseus	24-31
32663509-5	2020	While overexpression of B4GALT1 slightly enhanced the levels of large glycans on recombinant EPO, overexpression of B3GNT2 in EPO-expressing CHO cells significantly decreased the recombinant EPO LacNAc content, resulting in N-glycans terminating primarily with GlcNAc structures, a limited number of Gals, and nearly undetectable sialylation, which was also observed in sialyltransferases knock-out-B3GNT2 overexpression cell lines.	Polysaccharides	70-77	erythropoietin	Cricetulus griseus	93-96
32833579-7	2020	The levels of the glycan peaks (GPs) GP2, GP5, GP6, and GP7 were lower in the MGH group compared with the control group, whereas GP14 was significantly higher in the MGH group (p < 0.05).	Polysaccharides	18-24	glycoprotein 2	Homo sapiens	37-40
32817557-4	2020	Here, we present a panel of bacterial proteases that cleave mucin domains via distinct peptide- and glycan-based motifs, generating a diverse enzymatic toolkit for mucin-selective proteolysis.	Polysaccharides	100-106	LOC100508689	Homo sapiens	164-169
32866207-5	2020	Additionally, we isolated a subset of mAbs against an epitope cluster at the gp120-gp41 interface that recognize the highly conserved fusion peptide and the glycan at position 88 and have characteristics akin to several human-derived broadly neutralizing antibodies.	Polysaccharides	157-163	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	77-82
32590890-4	2020	Polysaccharides from the fruit of Lycium barbarum (LBP fraction) have a range of activities and have been demonstrate to repair the photodamage.	Polysaccharides	0-15	lipopolysaccharide binding protein	Mus musculus	51-54
32908915-9	2020	The polysaccharides could stimulate the proliferation of mouse splenocytes whether concanavalin A (ConA) and lipopolysaccharide (LPS) existed or not, strengthen peritoneal macrophages to devour neutral red, and increase the content of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) in serum.	Polysaccharides	4-19	interleukin 2	Mus musculus	235-248
32904601-0	2021	Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications.	Polysaccharides	115-122	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	65-70
32904601-0	2021	Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications.	Polysaccharides	115-122	angiotensin converting enzyme 2	Homo sapiens	89-93
32904601-7	2021	The PTM and glycan maps of HCoV-19 S and hACE2 provide additional structural details for studying the mechanisms underlying host attachment and the immune response of HCoV-19, as well as knowledge for developing desperately needed remedies and vaccines.	Polysaccharides	12-18	angiotensin converting enzyme 2	Homo sapiens	41-46
32908915-9	2020	The polysaccharides could stimulate the proliferation of mouse splenocytes whether concanavalin A (ConA) and lipopolysaccharide (LPS) existed or not, strengthen peritoneal macrophages to devour neutral red, and increase the content of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) in serum.	Polysaccharides	4-19	interleukin 2	Mus musculus	250-254
32908915-9	2020	The polysaccharides could stimulate the proliferation of mouse splenocytes whether concanavalin A (ConA) and lipopolysaccharide (LPS) existed or not, strengthen peritoneal macrophages to devour neutral red, and increase the content of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) in serum.	Polysaccharides	4-19	tumor necrosis factor	Mus musculus	260-287
32908915-9	2020	The polysaccharides could stimulate the proliferation of mouse splenocytes whether concanavalin A (ConA) and lipopolysaccharide (LPS) existed or not, strengthen peritoneal macrophages to devour neutral red, and increase the content of interleukin-2 (IL-2) and tumor necrosis factor-alpha (TNF-alpha) in serum.	Polysaccharides	4-19	tumor necrosis factor	Mus musculus	289-298
32908623-0	2020	Polysaccharides from Hemp Seed Protect against Cyclophosphamide-Induced Intestinal Oxidative Damage via Nrf2-Keap1 Signaling Pathway in Mice.	Polysaccharides	0-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-108
32854282-1	2020	Corn cob is an agricultural byproduct that produces an estimated waste burden in the thousands of tons annually, but it is also a good source of xylan, an important bioactive polysaccharide.	Polysaccharides	175-189	COB	Candida albicans	5-8
32983022-9	2020	On the other hand, the transparent variant was more commonly associated with penicillin-non-susceptible pneumococci and with strains presenting evidence of recombination events involving the genes coding for polysaccharide capsule and PspA, suggesting that pneumococcal transparent variants may present a higher ability to acquire exogenous DNA.	Polysaccharides	208-222	pneumococcal surface protein A	Streptococcus pneumoniae	235-239
32822483-0	2020	Predictive modeling of complex ABO glycan phenotypes by lectin microarrays.	Polysaccharides	35-41	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	31-34
32822483-2	2020	ABO blood groups or ABH antigens, in addition to other surface glycans, act as unique red blood cell (RBC) signatures and direct immune responses.	Polysaccharides	63-70	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	20-23
32788370-5	2020	The MHC-I-linked glycan steers a tapasin loop involved in peptide editing toward the binding groove.	Polysaccharides	17-23	TAP binding protein	Homo sapiens	33-40
32908623-0	2020	Polysaccharides from Hemp Seed Protect against Cyclophosphamide-Induced Intestinal Oxidative Damage via Nrf2-Keap1 Signaling Pathway in Mice.	Polysaccharides	0-15	kelch-like ECH-associated protein 1	Mus musculus	109-114
32843889-1	2020	Exostosin-like 3 (EXTL3) encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS), a sulfated polysaccharide that is ubiquitously distributed on the animal cell surface and in the extracellular matrix.	Polysaccharides	153-167	exostosin like glycosyltransferase 3	Homo sapiens	0-16
32843889-1	2020	Exostosin-like 3 (EXTL3) encodes the glycosyltransferases responsible for the biosynthesis of the backbone structure of heparan sulfate (HS), a sulfated polysaccharide that is ubiquitously distributed on the animal cell surface and in the extracellular matrix.	Polysaccharides	153-167	exostosin like glycosyltransferase 3	Homo sapiens	18-23
32289425-1	2020	A homogeneous water-soluble flaky polysaccharide named LRP-1 (18.82 kDa) was extracted and purified from the rare edible and medicinal fungi Leccinum rugosiceps.	Polysaccharides	34-48	LDL receptor related protein 1	Homo sapiens	55-60
32811831-5	2020	The synthetic glycans are accurately characterized by advanced NMR and MS approaches, the 3D structures are defined, and their potent binding activity with human DC-SIGN, a receptor associated with the gut lymphoid tissue, is disclosed.	Polysaccharides	14-21	CD209 molecule	Homo sapiens	162-169
32339582-3	2020	The Glucose Adsorption Capacity, Glucose Dialysis Retardation Index and the alpha-Amylase Activity Inhibition Ration of soybean soluble polysaccharides increased significantly, promotes intestinal flora growth in vitro after fermentation of mixed bacteria and microwave treatment.	Polysaccharides	136-151	1,4-alpha-glucan-branching enzyme 1, chloroplastic/amyloplastic	Glycine max	76-89
32289425-3	2020	The results show that LRP-1 is a new polysaccharide with a backbone which is mainly composed of  1-alpha-D-Fucp-3 ,  1-alpha-D-Rhap-3 ,  1-beta-D-Glcp-6 ,  1-beta-D-Glcp-3 ,  1-alpha-D-Glcp-4 ,  1-beta-D-Galp-6   and  1-alpha-D-Manp-6 .	Polysaccharides	37-51	LDL receptor related protein 1	Homo sapiens	22-27
32335118-3	2020	Polymeric (CTR) films were also built with both polysaccharides.	Polysaccharides	48-63	calcitonin receptor	Homo sapiens	11-14
32442537-7	2020	The extent of glycan alpha1,3-fucosylation on EGFR was positively correlated with the activation of EGFR in the presence/absence of epidermal growth factor (EGF) treatment.	Polysaccharides	14-20	epidermal growth factor receptor	Homo sapiens	46-50
32442537-7	2020	The extent of glycan alpha1,3-fucosylation on EGFR was positively correlated with the activation of EGFR in the presence/absence of epidermal growth factor (EGF) treatment.	Polysaccharides	14-20	epidermal growth factor receptor	Homo sapiens	100-104
32442537-7	2020	The extent of glycan alpha1,3-fucosylation on EGFR was positively correlated with the activation of EGFR in the presence/absence of epidermal growth factor (EGF) treatment.	Polysaccharides	14-20	epidermal growth factor	Homo sapiens	46-49
32412768-6	2020	Receiver operating characteristic (ROC) curve analysis demonstrated that the N-glycopeptides at sites N184 and N241 bearing a monofucosylated tri-antennary glycan A3G3F1S3, had the best diagnostic performance in detection of early NASH HCC, area under the curve (AUC) = 0.733 and 0.775, respectively, whereas alpha-fetoprotein (AFP) had an AUC of 0.692.	Polysaccharides	156-162	alpha fetoprotein	Homo sapiens	309-326
32532823-1	2020	Murine IgG3 glycan-targeting mAb often induces direct cell killing in the absence of immune effector cells or complement via a proinflammatory mechanism resembling oncotic necrosis.	Polysaccharides	12-18	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	7-11
32782291-5	2020	Manuka honey downregulated the genes encoding laminin- (eno), elastin- (ebps) and fibrinogen binding protein (fib), and icaA and icaD involved in biosynthesis of polysaccharide intercellular adhesin in both weakly and strongly adhering strain compared to the control (untreated biofilm).	Polysaccharides	162-176	AT695_RS11905	Staphylococcus aureus	82-108
32782291-5	2020	Manuka honey downregulated the genes encoding laminin- (eno), elastin- (ebps) and fibrinogen binding protein (fib), and icaA and icaD involved in biosynthesis of polysaccharide intercellular adhesin in both weakly and strongly adhering strain compared to the control (untreated biofilm).	Polysaccharides	162-176	AT695_RS11905	Staphylococcus aureus	82-85
32784866-5	2020	The distribution of glycans on individual chains was also affected, with the gamma chain, responsible for physiological functions of fibrinogen (such as coagulation and platelet aggregation), being most prone to these alterations.	Polysaccharides	20-27	fibrinogen beta chain	Homo sapiens	133-143
32784866-7	2020	Consequently, investigation of fibrinogen glycans can offer better insight into fibrinogen-related complications observed in ESRD-PD patients and, additionally, contribute to prognosis, choice of personalised therapy, determination of peritoneal membrane damage, and the length of utilization of peritoneum for dialysis.	Polysaccharides	42-49	fibrinogen beta chain	Homo sapiens	31-41
32412768-6	2020	Receiver operating characteristic (ROC) curve analysis demonstrated that the N-glycopeptides at sites N184 and N241 bearing a monofucosylated tri-antennary glycan A3G3F1S3, had the best diagnostic performance in detection of early NASH HCC, area under the curve (AUC) = 0.733 and 0.775, respectively, whereas alpha-fetoprotein (AFP) had an AUC of 0.692.	Polysaccharides	156-162	alpha fetoprotein	Homo sapiens	328-331
32484235-3	2020	Whole genome re-sequencing revealed a mutation in ALG12 (Asparagine-Linked Glycosylation 12) that encodes the mannosyltransferase responsible for adding the eighth mannose residue in an alpha-1,6 linkage to the dolichol-PP-oligosaccharide N-glycosylation glycan tree precursors.	Polysaccharides	255-261	homolog of asparagine-linked glycosylation 12	Arabidopsis thaliana	50-55
32315099-6	2020	We probed the two lectins concanavalin A and langerin with different glycans on multivalent scaffolds, revealing strong spacing-, density-, and ligand-dependent binding.	Polysaccharides	69-76	CD207 molecule	Homo sapiens	45-53
32756606-3	2020	We see that some ACE2 glycans interact with the S fragments, and glycans are influencing the conformation of the ACE2 receptor.	Polysaccharides	22-29	angiotensin converting enzyme 2	Homo sapiens	17-21
32756606-3	2020	We see that some ACE2 glycans interact with the S fragments, and glycans are influencing the conformation of the ACE2 receptor.	Polysaccharides	22-29	angiotensin converting enzyme 2	Homo sapiens	113-117
32188998-3	2020	Unlike VP8* from P[8]-3 and P[4] strains, the P[8]-4 VP8* protein attached to glycans from saliva samples regardless of the donors Secretor status.	Polysaccharides	78-85	S100 calcium binding protein A8	Homo sapiens	46-56
32753699-6	2020	Contrariwise, IgG subclass distribution against self glycans showed clear dominance for IgG3 presence (p = 0.0017) and more restricted IgG-subclass distributions (i.e. a single IgG subclass, p = 0.0133).	Polysaccharides	53-60	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	88-92
32675559-10	2020	Finally, in HCV high levels of the anti-inflammatory galactosylated and sialylated glycans were associated with low plasma levels of aspartate aminotransferase (AST), low CD8 T-cell activation, and high CD8 T-cell exhaustion.	Polysaccharides	83-90	solute carrier family 17 member 5	Homo sapiens	161-164
32675559-10	2020	Finally, in HCV high levels of the anti-inflammatory galactosylated and sialylated glycans were associated with low plasma levels of aspartate aminotransferase (AST), low CD8 T-cell activation, and high CD8 T-cell exhaustion.	Polysaccharides	83-90	CD8a molecule	Homo sapiens	171-174
32675559-10	2020	Finally, in HCV high levels of the anti-inflammatory galactosylated and sialylated glycans were associated with low plasma levels of aspartate aminotransferase (AST), low CD8 T-cell activation, and high CD8 T-cell exhaustion.	Polysaccharides	83-90	CD8a molecule	Homo sapiens	203-206
32681764-9	2020	These glycan changes were accompanied by upregulation of sialyltransferase, St3gal2 and St6gal1 and mannosidase Man1a genes in old epidermal stem cells.	Polysaccharides	6-12	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Homo sapiens	76-83
32681764-9	2020	These glycan changes were accompanied by upregulation of sialyltransferase, St3gal2 and St6gal1 and mannosidase Man1a genes in old epidermal stem cells.	Polysaccharides	6-12	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	88-95
32507185-7	2020	Based on the findings in this study, we concluded that the wound healing activities of the GLP-2 fraction can provide the scientific basis for the development of G. lemaneiformis polysaccharides based product for wound management.	Polysaccharides	179-194	glucagon	Homo sapiens	91-96
32567721-4	2020	Mechanistically, loss of SEZ6 in vitro and in vivo prevented modification of GluK2/3 with the human natural killer-1 (HNK-1) glycan, a modulator of GluK2/3 function.	Polysaccharides	125-131	seizure related 6 homolog	Homo sapiens	25-29
32567721-4	2020	Mechanistically, loss of SEZ6 in vitro and in vivo prevented modification of GluK2/3 with the human natural killer-1 (HNK-1) glycan, a modulator of GluK2/3 function.	Polysaccharides	125-131	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	77-84
32567721-4	2020	Mechanistically, loss of SEZ6 in vitro and in vivo prevented modification of GluK2/3 with the human natural killer-1 (HNK-1) glycan, a modulator of GluK2/3 function.	Polysaccharides	125-131	beta-1,3-glucuronyltransferase 1	Homo sapiens	118-123
32567721-4	2020	Mechanistically, loss of SEZ6 in vitro and in vivo prevented modification of GluK2/3 with the human natural killer-1 (HNK-1) glycan, a modulator of GluK2/3 function.	Polysaccharides	125-131	glutamate ionotropic receptor kainate type subunit 2	Homo sapiens	148-155
32507236-5	2020	The isomeric glycan structures of AZGP1 in these spots were systematically characterized both at composition level and at structure level.	Polysaccharides	13-19	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	34-39
32507236-6	2020	Our results revealed 10 glycan compositions for salivary AZGP1, including core fucosylated glycans on Asn128 and sialylated glycans on Asn109 and Asn112.	Polysaccharides	24-30	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	57-62
32507236-6	2020	Our results revealed 10 glycan compositions for salivary AZGP1, including core fucosylated glycans on Asn128 and sialylated glycans on Asn109 and Asn112.	Polysaccharides	91-98	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	57-62
32507236-6	2020	Our results revealed 10 glycan compositions for salivary AZGP1, including core fucosylated glycans on Asn128 and sialylated glycans on Asn109 and Asn112.	Polysaccharides	124-131	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	57-62
32507236-7	2020	We further compared the glycan structures of salivary AZGP1 from lung cancer group and control group.	Polysaccharides	24-30	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	54-59
32507236-9	2020	In total, 15 glycan compositions and 22 potential glycan structures were identified and characterized for AZGP1, including some different structures with the same compositions.	Polysaccharides	13-19	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	106-111
32507236-9	2020	In total, 15 glycan compositions and 22 potential glycan structures were identified and characterized for AZGP1, including some different structures with the same compositions.	Polysaccharides	50-56	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	106-111
32462673-4	2020	The mechanism of interaction and activation of MPL by mutant CALR is unique, not only due to the latter forming a homomultimeric complex through a novel mutant-specific sequence generated by frameshift mutation, but also for its ability to interact with immature asparagine-linked glycan for eventual engagement with immature MPL in the endoplasmic reticulum.	Polysaccharides	281-287	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	47-50
32462673-4	2020	The mechanism of interaction and activation of MPL by mutant CALR is unique, not only due to the latter forming a homomultimeric complex through a novel mutant-specific sequence generated by frameshift mutation, but also for its ability to interact with immature asparagine-linked glycan for eventual engagement with immature MPL in the endoplasmic reticulum.	Polysaccharides	281-287	calreticulin	Homo sapiens	61-65
32540477-1	2020	Previously, we obtained a purified polysaccharide (PNP40c-1) from Pinus koraiensis pine nut and reported its protective effect on carbon tetrachloride (CCl4)-induced liver injury in vitro.	Polysaccharides	35-49	NUT midline carcinoma, family member 1	Mus musculus	88-91
32540477-1	2020	Previously, we obtained a purified polysaccharide (PNP40c-1) from Pinus koraiensis pine nut and reported its protective effect on carbon tetrachloride (CCl4)-induced liver injury in vitro.	Polysaccharides	35-49	chemokine (C-C motif) ligand 4	Mus musculus	152-156
32696775-0	2020	Corn silk crude polysaccharide exerts anti-pancreatic cancer activity by blocking the EGFR/PI3K/AKT/CREB signaling pathway.	Polysaccharides	16-30	epidermal growth factor receptor	Homo sapiens	86-90
32696775-0	2020	Corn silk crude polysaccharide exerts anti-pancreatic cancer activity by blocking the EGFR/PI3K/AKT/CREB signaling pathway.	Polysaccharides	16-30	AKT serine/threonine kinase 1	Homo sapiens	96-99
32696775-0	2020	Corn silk crude polysaccharide exerts anti-pancreatic cancer activity by blocking the EGFR/PI3K/AKT/CREB signaling pathway.	Polysaccharides	16-30	cAMP responsive element binding protein 1	Homo sapiens	100-104
32484235-3	2020	Whole genome re-sequencing revealed a mutation in ALG12 (Asparagine-Linked Glycosylation 12) that encodes the mannosyltransferase responsible for adding the eighth mannose residue in an alpha-1,6 linkage to the dolichol-PP-oligosaccharide N-glycosylation glycan tree precursors.	Polysaccharides	255-261	homolog of asparagine-linked glycosylation 12	Arabidopsis thaliana	57-91
32535537-0	2020	Activation of NLRP3 inflammasome in RAW 264.7 cells by polysaccharides extracted from Grateloupia livida (Harv.)	Polysaccharides	55-70	NLR family, pyrin domain containing 3	Mus musculus	14-19
32367478-9	2020	Immobilized neo-glycoproteins of all modification densities showed binding of Gal-3 with increasing glycan density.	Polysaccharides	100-106	galectin 3	Homo sapiens	78-83
32367479-1	2020	Cephalosporium curvulum lectin (CSL), a lectin from pathogenic fungus has exquisite specificity towards alpha1-6 linkage of core fucosylated glycans, expressed in hepatocellular and pancreatic cancer.	Polysaccharides	141-148	immunoglobulin kappa variable 3-31 (pseudogene)	Homo sapiens	104-112
33397553-2	2020	In this study, the dendrimer polyamidoamine (PAMAM) and the polysaccharide hyaluronic acid (HA) were connected through the substrate polypeptide (Gly-PLGLAG-Cys) of MMP-2 to obtain the MMP-2-responsive nanocarrier HA-pep-PAMAM.	Polysaccharides	60-74	matrix metallopeptidase 2	Mus musculus	165-170
33397553-2	2020	In this study, the dendrimer polyamidoamine (PAMAM) and the polysaccharide hyaluronic acid (HA) were connected through the substrate polypeptide (Gly-PLGLAG-Cys) of MMP-2 to obtain the MMP-2-responsive nanocarrier HA-pep-PAMAM.	Polysaccharides	60-74	matrix metallopeptidase 2	Mus musculus	185-190
32454127-5	2020	Here we show that prion-infected knockin mice expressing an additional PrP glycan (tri-glycosylated PrP) develop new plaque-like deposits on neuronal cell membranes, along the subarachnoid space, and periventricularly, suggestive of high prion mobility and transit through the interstitial fluid.	Polysaccharides	75-81	prion protein	Mus musculus	71-74
32242754-3	2020	In our research, five sugar molecules (Mannose, Galactose, Glucose, Malt disaccharide, and Maltotriose) conjugated PEG600-DSPE were synthesized, of which polysaccharides were first discovered by us as sugar ligands to modify liposomes, which interacts with over expressive GLUT on cancer cells.	Polysaccharides	154-169	glutaminase	Rattus norvegicus	273-277
32454127-5	2020	Here we show that prion-infected knockin mice expressing an additional PrP glycan (tri-glycosylated PrP) develop new plaque-like deposits on neuronal cell membranes, along the subarachnoid space, and periventricularly, suggestive of high prion mobility and transit through the interstitial fluid.	Polysaccharides	75-81	prion protein	Mus musculus	100-103
32723915-5	2020	We then solved crystal structures of NJPyV and HPyV12 VP1 alone and in complex with sialylated glycans.	Polysaccharides	95-102	VP1	Human polyomavirus 12	54-57
32493777-8	2020	These results indicate that the lack of exo-beta-1,3-galactosidase activity alters cell wall extensibility in roots, a phenotype that could be explained by the involvement of galactosidases in AGP glycan biosynthesis.	Polysaccharides	197-203	Phosphate-responsive 1 family protein	Arabidopsis thaliana	40-43
32493777-8	2020	These results indicate that the lack of exo-beta-1,3-galactosidase activity alters cell wall extensibility in roots, a phenotype that could be explained by the involvement of galactosidases in AGP glycan biosynthesis.	Polysaccharides	197-203	fucosyltransferase 1	Arabidopsis thaliana	44-52
32766577-2	2020	Here we demonstrate that S is recognized in a glycan-dependent manner by multiple innate immune receptors including the mannose receptor MR/CD206, DC-SIGN/CD209, L-SIGN/CD209L, and MGL/CLEC10A/CD301.	Polysaccharides	46-52	C-type lectin domain containing 10A	Homo sapiens	193-198
32487563-3	2020	Vesicles containing matrix polysaccharides are thought to be transported by the FRA1 kinesin to facilitate their secretion along cortical microtubules.	Polysaccharides	27-42	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	80-84
32487563-9	2020	We propose that modulation of CMU protein levels and microtubule localization by FRA1 provides a mechanism to stabilize the sites of deposition of both cellulose and matrix polysaccharides.	Polysaccharides	173-188	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	81-85
32850359-11	2020	Conclusions: These glycan changes are known to be integral to cancer cell survival and metastases, suggesting a possible mechanism of action, linking GATA2 and 3, and invasiveness of both ovarian and TNBC cells in vitro.	Polysaccharides	19-25	GATA binding protein 2	Homo sapiens	150-161
32686492-1	2022	A novel water-soluble polysaccharide, named ICP-1, was isolated and purified by Sephadex G-200 after extracting the crude polysaccharide (ICP) from Imperial Chrysanthemum.	Polysaccharides	22-36	ATPase phospholipid transporting 8B1	Homo sapiens	44-49
32743578-4	2020	Our results highlight roles for glycans in sterically masking polypeptide epitopes and directly modulating Spike-ACE2 interactions.	Polysaccharides	32-39	angiotensin converting enzyme 2	Homo sapiens	113-117
32705969-0	2021	Polysaccharides like pentagalloylglucose, parishin a and stevioside inhibits the viral entry by binding the Zika virus envelope protein.	Polysaccharides	0-15	endogenous retrovirus group K member 6, envelope	Homo sapiens	119-135
32573644-0	2020	Fruiting body polysaccharides of Hericium erinaceus induce apoptosis in human colorectal cancer cells via ROS generation mediating caspase-9-dependent signaling pathways.	Polysaccharides	14-29	caspase 9	Homo sapiens	131-140
32724854-1	2020	Chondroitin sulfate E (CS-E) is a sulfated polysaccharide that contains repeating disaccharides of 4,6-disulfated N-acetylgalactosamine and glucuronic acid residues.	Polysaccharides	43-57	cystathionase (cystathionine gamma-lyase)	Mus musculus	0-21
32724854-1	2020	Chondroitin sulfate E (CS-E) is a sulfated polysaccharide that contains repeating disaccharides of 4,6-disulfated N-acetylgalactosamine and glucuronic acid residues.	Polysaccharides	43-57	cystathionase (cystathionine gamma-lyase)	Mus musculus	23-27
32544320-5	2020	The selectivity for different glycan types was studied using bovine fetuin, asialofetuin, IgG, ribonuclease B, and alpha-1 acid glycoprotein (AGP) by PGC-LC-MS. Comprehensive structural isomeric separation of glycopeptides was observed by high-resolution MS and confirmed by MS/MS.	Polysaccharides	30-36	alpha-1-acid glycoprotein	Bos taurus	115-140
32544320-5	2020	The selectivity for different glycan types was studied using bovine fetuin, asialofetuin, IgG, ribonuclease B, and alpha-1 acid glycoprotein (AGP) by PGC-LC-MS. Comprehensive structural isomeric separation of glycopeptides was observed by high-resolution MS and confirmed by MS/MS.	Polysaccharides	30-36	alpha-1-acid glycoprotein	Bos taurus	142-145
32475574-3	2020	The extracted crude polysaccharides were purified using ion-exchange and gel-filtration chromatographies and eluted a single symmetrical narrow peak, showing a homogenous fraction (MRP-P1) with a molecular weight of 4.87 x 104 Da.	Polysaccharides	20-35	tRNA methyltransferase 10C, mitochondrial RNase P subunit	Homo sapiens	181-187
32335047-1	2020	A neutral tea polysaccharide (TPSN) was isolated from green tea.	Polysaccharides	14-28	TAP binding protein	Homo sapiens	30-34
32366695-0	2020	Site-specific glycan analysis of the SARS-CoV-2 spike.	Polysaccharides	14-20	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	48-53
32366695-5	2020	This analysis enables mapping of the glycan-processing states across the trimeric viral spike.	Polysaccharides	37-43	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	88-93
32475574-4	2020	The surface morphology of polysaccharides and functional groups of MRP-P1 were determined by employing scanning electron microscopy and Fourier-transform infrared spectroscopy, respectively.	Polysaccharides	26-41	tRNA methyltransferase 10C, mitochondrial RNase P subunit	Homo sapiens	67-73
32699847-3	2020	Here we use murine leukemia viruses pseudotyped with Spike from SARS-CoV or SARS-CoV-2 to demonstrate that ACE2-mediated coronavirus entry can be mitigated by heparin, a heparan sulfate-related glycan, or by genetic ablation of biosynthetic enzymes for the cell surface heparan sulfate proteoglycans (HSPGs).	Polysaccharides	194-200	angiotensin converting enzyme 2	Homo sapiens	107-111
31712151-7	2020	Among them, polysaccharide PK3 not only has a high content of fucose and uronic acid, but also has a strong activity to stimulate murine macrophage cells and increase their phagocytosis rate up to 170%.	Polysaccharides	12-26	pyruvate kinase, muscle	Mus musculus	27-30
32217096-0	2020	Antiviral activity of a polysaccharide from Radix Isatidis (Isatis indigotica Fortune) against hepatitis B virus (HBV) in vitro via activation of JAK/STAT signal pathway.	Polysaccharides	24-38	jak	None	146-149
32217096-0	2020	Antiviral activity of a polysaccharide from Radix Isatidis (Isatis indigotica Fortune) against hepatitis B virus (HBV) in vitro via activation of JAK/STAT signal pathway.	Polysaccharides	24-38	stat	None	150-154
32501643-6	2020	APOE structures with various glycan residues were predicted.	Polysaccharides	29-35	apolipoprotein E	Homo sapiens	0-4
32525659-1	2020	Chondroitin sulfate type E (CS-E) is a sulfated polysaccharide that shows several interesting biological activities, such as the modulation of the neuronal growth factor signaling and its interaction with Langerin, a C-type lectin with a crucial role in the immunological system.	Polysaccharides	48-62	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	0-32
32525659-2	2020	However, applications of CS-E are hampered by the typical heterogeneous structure of the natural polysaccharide.	Polysaccharides	97-111	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	25-29
32409578-7	2020	The glycan-remodeled cells bound STx1 via N-glycans of glycoproteins and were sensitive to STx1 even without Gb3 expression, indicating that P1-containing glycoproteins also function as STx receptors.	Polysaccharides	4-10	syntaxin 1A	Homo sapiens	33-37
32409578-7	2020	The glycan-remodeled cells bound STx1 via N-glycans of glycoproteins and were sensitive to STx1 even without Gb3 expression, indicating that P1-containing glycoproteins also function as STx receptors.	Polysaccharides	4-10	syntaxin 1A	Homo sapiens	91-95
32409578-7	2020	The glycan-remodeled cells bound STx1 via N-glycans of glycoproteins and were sensitive to STx1 even without Gb3 expression, indicating that P1-containing glycoproteins also function as STx receptors.	Polysaccharides	4-10	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	109-112
32724797-7	2020	Further, we conducted CCK8, colony formation, Annexin V-FITC/PI, Western blot, RT-PCR, and plasmid transfection assays to analyze the mechanism by which Huaier polysaccharides play an antitumor role.	Polysaccharides	160-175	annexin A5	Homo sapiens	46-55
32724797-9	2020	Moreover, through cell proliferation assays, Western blot, RT-PCR, and detection of Livin expression at the mRNA and protein levels, we found that Huaier polysaccharides could promote gastric cancer cell apoptosis and inhibit gastric cancer cell proliferation in a time- and dose-dependent manner.	Polysaccharides	154-169	baculoviral IAP repeat containing 7	Homo sapiens	84-89
32724797-10	2020	Finally, we demonstrated that Huaier polysaccharides promote gastric cancer cell apoptosis through the regulation of Livin expression.	Polysaccharides	37-52	baculoviral IAP repeat containing 7	Homo sapiens	117-122
32620774-4	2020	The HMO pathways, which include enzymes with a previously unknown structural fold and specificity, were upregulated together with additional glycan-utilization loci during growth on selected HMOs and in co-cultures with Akkermansia muciniphila on mucin, suggesting an additional role in enabling cross-feeding and access to mucin O-glycans.	Polysaccharides	141-147	LOC100508689	Homo sapiens	232-237
32620774-4	2020	The HMO pathways, which include enzymes with a previously unknown structural fold and specificity, were upregulated together with additional glycan-utilization loci during growth on selected HMOs and in co-cultures with Akkermansia muciniphila on mucin, suggesting an additional role in enabling cross-feeding and access to mucin O-glycans.	Polysaccharides	141-147	LOC100508689	Homo sapiens	247-252
32616483-9	2020	Only few glycans were associated with ACE inhibitor/ARBs, while none associated with insulin and SU derivative use.	Polysaccharides	9-16	angiotensin I converting enzyme	Homo sapiens	38-41
32760719-9	2020	These results indicate that targeting glycan moieties on immunotherapeutic vaccines should not only be validated for target binding, but also on the continued effects on biology, such as antigen presentation to both CD8+ and CD4+ T cells.	Polysaccharides	38-44	CD8a molecule	Homo sapiens	216-219
32760719-9	2020	These results indicate that targeting glycan moieties on immunotherapeutic vaccines should not only be validated for target binding, but also on the continued effects on biology, such as antigen presentation to both CD8+ and CD4+ T cells.	Polysaccharides	38-44	CD4 molecule	Homo sapiens	225-228
32109505-10	2020	Simulation of THz spectra based on the molecular dynamics of unglycosylated and the two glycosylated TRPM8 models in lipid membrane and solvation box showed that glycan structure strongly influences the THz spectrum of the channel and of other components from the simulation system.	Polysaccharides	162-168	transient receptor potential cation channel subfamily M member 8	Homo sapiens	101-106
32749562-3	2020	Experiments on C57BL/6 mice with Lewis lung carcinoma demonstrate the possibility of reducing the expression of CD279 and CD274 on the peripheral blood and tumor tissue lymphocytes under the effects of Tussilago farfara L. polysaccharides.	Polysaccharides	223-238	CD274 antigen	Mus musculus	122-127
32556248-3	2020	The mutation likely altered human SAMPs, triggering multiple events, including emergence of human-adapted pathogens with strong preference for Neu5Ac recognition and/or presenting Neu5Ac-containing molecular mimics of human glycans, which can suppress immune responses via CD33-related-Siglec engagement.	Polysaccharides	224-231	CD33 molecule	Homo sapiens	273-277
32501643-9	2020	The glycan sequence N-acetylgalactosamine, galactose, and sialic acid was consistently expressed on serine 94, threonine 194, and threonine 289 of APOE in L5 and was predicted to contribute to L5"s negative surface charge and hydrophilicity.	Polysaccharides	4-10	apolipoprotein E	Homo sapiens	147-151
32501643-10	2020	The electrostatic force between the negatively charged sialic acid-containing glycan residue of APOE and positively charged amino acids at the receptor-binding area suggested that glycosylation interferes with APOE"s attraction to receptors, lipid-binding ability, and lipid transportation and metabolism functions.	Polysaccharides	78-84	apolipoprotein E	Homo sapiens	96-100
32501643-10	2020	The electrostatic force between the negatively charged sialic acid-containing glycan residue of APOE and positively charged amino acids at the receptor-binding area suggested that glycosylation interferes with APOE"s attraction to receptors, lipid-binding ability, and lipid transportation and metabolism functions.	Polysaccharides	78-84	apolipoprotein E	Homo sapiens	210-214
32171833-4	2020	Results showed that red kidney bean polysaccharides (RK) could alleviate the symptoms of emaciation, decreased the levels of FBG, GSP, TC, LDL-c and obviously reduced the concentration of TG and HOMA-IR (p < 0.05).	Polysaccharides	36-51	component of oligomeric golgi complex 2	Mus musculus	139-144
32747024-8	2020	By using mutant strains deficient in capsular polysaccharide (CPS) or lipoprotein maturation in combination with purified lipoteichoic acid (LTA) from the latter mutant strain, it was showed that G-CSF production is mainly mediated by S. suis lipoproteins.	Polysaccharides	46-60	colony stimulating factor 3 (granulocyte)	Mus musculus	196-201
31730990-1	2020	The polysaccharide fraction of Bletilla ochracea (BOP) was isolated from its tubers, and purified by DEAE-52 Cellulose and Sephadex G-200 column chromatography.	Polysaccharides	4-18	SET and MYND domain containing 1	Mus musculus	50-53
32171839-0	2020	Anti-angiogenic effect of a chemically sulfated polysaccharide from Phellinus ribis by inhibiting VEGF/VEGFR pathway.	Polysaccharides	48-62	vascular endothelial growth factor A	Mus musculus	98-102
32173428-5	2020	The results showed that the drug loading efficiency and the sustained release capacity of agar hydrogels could be enhanced by the addition of kappa-carrageenan, and the release profile was mainly dominated by the electrostatic interaction between the MET and the polysaccharides.	Polysaccharides	263-278	SAFB like transcription modulator	Homo sapiens	251-254
31734359-4	2020	Structural investigations including FT-IR, Raman spectra and 1D, 2D NMR analysis revealed that selenium in CSe-tps1 replaced the hydroxyl group at the C-6 position in the polysaccharide with the form of selenyl ester, while most of the selenium in ASe-tps1 replaced the hydroxyl group at the C-1 and C-6 position in the form of the SeH bond on the branch of the polysaccharide.	Polysaccharides	171-185	tryptase alpha/beta 1	Homo sapiens	111-115
32179120-0	2020	Extraction of polysaccharides from maca: Characterization and immunoregulatory effects on CD4+ T cells.	Polysaccharides	14-29	CD4 molecule	Homo sapiens	90-93
32519803-0	2020	Polysaccharides derived from Balanophora polyandra significantly suppressed the proliferation of ovarian cancer cells through P53-mediated pathway.	Polysaccharides	0-15	tumor protein p53	Homo sapiens	126-129
32311369-1	2020	This work describes the development of polysaccharide-coated liposomes to modulate the delivery of epidermal growth factor (EGF), with the aim to produce different EGF release profiles depending on the milieu of infected wounds.	Polysaccharides	39-53	epidermal growth factor	Homo sapiens	99-122
32311369-1	2020	This work describes the development of polysaccharide-coated liposomes to modulate the delivery of epidermal growth factor (EGF), with the aim to produce different EGF release profiles depending on the milieu of infected wounds.	Polysaccharides	39-53	epidermal growth factor	Homo sapiens	124-127
32311369-1	2020	This work describes the development of polysaccharide-coated liposomes to modulate the delivery of epidermal growth factor (EGF), with the aim to produce different EGF release profiles depending on the milieu of infected wounds.	Polysaccharides	39-53	epidermal growth factor	Homo sapiens	164-167
32483376-5	2020	Using a combination of the expression system of the Lec4 CHO cell line and this two-step glycan-editing approach, opioid receptor delta 1 (OPRD1) was investigated to correlate its glycostructures with the biological functions of receptor dimerization, agonist-induced signaling and internalization.	Polysaccharides	89-95	delta-type opioid receptor	Cricetulus griseus	114-137
32205858-4	2020	We carried out glycan structure analysis of glycodelin expressed in HEC-1B human endometrial carcinoma cells (HEC-1B Gd) by mass spectrometry glycomics strategies.	Polysaccharides	15-21	progestagen associated endometrial protein	Homo sapiens	44-54
32205858-6	2020	However, several differences, as compared with previously reported glycan structures of normal human decidualized endometrium-derived glycodelin isoform, glycodelin-A (GdA), were also found.	Polysaccharides	67-73	progestagen associated endometrial protein	Homo sapiens	134-144
32205858-6	2020	However, several differences, as compared with previously reported glycan structures of normal human decidualized endometrium-derived glycodelin isoform, glycodelin-A (GdA), were also found.	Polysaccharides	67-73	progestagen associated endometrial protein	Homo sapiens	154-166
32205858-6	2020	However, several differences, as compared with previously reported glycan structures of normal human decidualized endometrium-derived glycodelin isoform, glycodelin-A (GdA), were also found.	Polysaccharides	67-73	progestagen associated endometrial protein	Homo sapiens	168-171
32357974-7	2020	Chemical inhibition of Peptide:N-Glycanase (PNGase), the endoglycosidase responsible for the removal of glycans from misfolded and retrotranslocated glycoproteins, greatly reduced presentation of this subset of deamidated HLA-bound peptides.	Polysaccharides	104-111	N-glycanase 1	Homo sapiens	23-42
32357974-7	2020	Chemical inhibition of Peptide:N-Glycanase (PNGase), the endoglycosidase responsible for the removal of glycans from misfolded and retrotranslocated glycoproteins, greatly reduced presentation of this subset of deamidated HLA-bound peptides.	Polysaccharides	104-111	N-glycanase 1	Homo sapiens	44-50
32243627-1	2020	Intelectin (ITLN) is a new type of glycan-binding lectin.	Polysaccharides	35-41	intelectin 1	Homo sapiens	0-10
32243627-1	2020	Intelectin (ITLN) is a new type of glycan-binding lectin.	Polysaccharides	35-41	intelectin 1	Homo sapiens	12-16
32610625-6	2020	Estimation of the polymer conformation in solution, through evaluation of the Mark-Houwink parameter coefficient (alpha), confirmed that acid hydrolysis influenced the polysaccharides" conformation.	Polysaccharides	168-183	microtubule affinity regulating kinase 1	Homo sapiens	78-82
32573677-5	2020	Asparagine-linked glycan-dependent folding and deacylation by PGAP1 work together to ensure that correctly folded GPI-APs are transported from the ER to the Golgi.	Polysaccharides	18-24	post-GPI attachment to proteins inositol deacylase 1	Homo sapiens	62-67
32541028-5	2020	Guided by the structure of the 237 Fab:Tn-OTS8-glycopeptide complex, here we conducted a deep mutational scan showing that residues flanking the Tn-glycan contributed significant binding energy to the interaction.	Polysaccharides	148-154	podoplanin	Mus musculus	42-46
32637953-0	2020	A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies.	Polysaccharides	2-8	FA complementation group B	Homo sapiens	69-72
32637953-0	2020	A glycan cluster on the SARS-CoV-2 spike ectodomain is recognized by Fab-dimerized glycan-reactive antibodies.	Polysaccharides	83-89	FA complementation group B	Homo sapiens	69-72
32637953-4	2020	Here we demonstrate binding to the SARS-CoV-2 S protein by a category of Fab-dimerized glycan-reactive (FDG) HIV-1-induced broadly neutralizing antibodies (bnAbs).	Polysaccharides	87-93	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	35-36
32637953-4	2020	Here we demonstrate binding to the SARS-CoV-2 S protein by a category of Fab-dimerized glycan-reactive (FDG) HIV-1-induced broadly neutralizing antibodies (bnAbs).	Polysaccharides	87-93	FA complementation group B	Homo sapiens	73-76
32637953-7	2020	Highlights: Fab-dimerized, glycan-reactive (FDG) HIV-1 bnAbs cross-react with SARS-CoV-2 spike.3.1 A resolution cryo-EM structure reveals quaternary S2 epitope for HIV-1 bnAb 2G12.2G12 targets glycans, at positions 709, 717 and 801, in the SARS-CoV-2 spike.Our studies suggest a common epitope for FDG antibodies centered around glycan 709.	Polysaccharides	193-200	FA complementation group B	Homo sapiens	12-15
32637953-7	2020	Highlights: Fab-dimerized, glycan-reactive (FDG) HIV-1 bnAbs cross-react with SARS-CoV-2 spike.3.1 A resolution cryo-EM structure reveals quaternary S2 epitope for HIV-1 bnAb 2G12.2G12 targets glycans, at positions 709, 717 and 801, in the SARS-CoV-2 spike.Our studies suggest a common epitope for FDG antibodies centered around glycan 709.	Polysaccharides	193-199	FA complementation group B	Homo sapiens	12-15
32604896-0	2020	Polysaccharide Multilayer Films in Sensors for Detecting Prostate Tumor Cells Based on Hyaluronan-CD44 Interactions.	Polysaccharides	0-14	CD44 molecule (Indian blood group)	Homo sapiens	98-102
32251761-0	2020	Polysaccharide from Schisandra chinensis acts via LRP-1 to reverse microglia activation through suppression of the NF-kappaB and MAPK signaling.	Polysaccharides	0-14	low density lipoprotein receptor-related protein 1	Mus musculus	50-55
32251761-0	2020	Polysaccharide from Schisandra chinensis acts via LRP-1 to reverse microglia activation through suppression of the NF-kappaB and MAPK signaling.	Polysaccharides	0-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-124
32251761-3	2020	AIM OF THE STUDY: In this paper, we studied whether SCP2-1, a natural product of homogeneous polysaccharide from S. Chinensis, could improve M1 and M2 polarization and inhibit neuroinflammation through lipoprotein receptor-related protein-1 (LRP-1), and futher exerted anti-inflammatory and neuroprotective effects.	Polysaccharides	93-107	sterol carrier protein 2, liver	Mus musculus	52-56
32251761-4	2020	MATERIALS AND METHODS: SCP2-1 was obtained from crude polysaccharide of S. Chinensis, BV2 microglia cells and mice stimulated by LPS were served to detect the positive role of SCP2-1 in M1/M2 polarization.	Polysaccharides	54-68	sterol carrier protein 2, liver	Mus musculus	23-27
32452513-2	2020	This study was conducted in order to clarify the effect of Cosmc on the growth and metastasis of BC cell lines of different molecular types, which may be implicated in the regulation of Tn and T glycans.	Polysaccharides	195-202	C1GALT1-specific chaperone 1	Mus musculus	59-64
32607438-4	2020	The anti-inflammatory activities of both bikunin and the synthetic 24-mer were determined, and the results demonstrate that both the glycan and the core protein are important for anti-inflammatory activities of bikunin by reducing macrophage production of proinflammatory cytokines.	Polysaccharides	133-139	alpha-1-microglobulin/bikunin precursor	Homo sapiens	211-218
32605327-1	2020	The water-soluble polysaccharide EP2, from Enteromorpha prolifera, belongs to the group of polysaccharides known as glucuronoxylorhamnan, which mainly contains glucuronic acid (GlcA), xylose (Xyl), and rhamnose (Rha).	Polysaccharides	18-32	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	33-36
32605327-1	2020	The water-soluble polysaccharide EP2, from Enteromorpha prolifera, belongs to the group of polysaccharides known as glucuronoxylorhamnan, which mainly contains glucuronic acid (GlcA), xylose (Xyl), and rhamnose (Rha).	Polysaccharides	91-106	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	33-36
32629603-3	2020	However, the crystal structure of the protein has not been resolved for the time being and the atomic description of Siglec-10 interactions with complex glycans has not been previously unraveled.	Polysaccharides	153-160	sialic acid binding Ig like lectin 10	Homo sapiens	117-126
32724752-2	2020	The loss of CD55 and CD59, two GPI-anchored proteins on red blood cell surfaces, from mutations in the X-linked phosphatidylinositol glycan class A (PIGA) gene, causes unrestricted proliferation of complement activation.	Polysaccharides	133-139	CD55 molecule (Cromer blood group)	Homo sapiens	12-16
32724752-2	2020	The loss of CD55 and CD59, two GPI-anchored proteins on red blood cell surfaces, from mutations in the X-linked phosphatidylinositol glycan class A (PIGA) gene, causes unrestricted proliferation of complement activation.	Polysaccharides	133-139	CD59 molecule (CD59 blood group)	Homo sapiens	21-25
32724752-2	2020	The loss of CD55 and CD59, two GPI-anchored proteins on red blood cell surfaces, from mutations in the X-linked phosphatidylinositol glycan class A (PIGA) gene, causes unrestricted proliferation of complement activation.	Polysaccharides	133-139	phosphatidylinositol glycan anchor biosynthesis class A	Homo sapiens	149-153
32559360-3	2020	Since protein-bound polysaccharides (PBP) from the Coriolus versicolor fungus are believed to inhibit the growth of cancers, in the present study, we investigated whether these PBP influence crosstalk between triple-negative 4T1 breast cancer cells and RAW 264.7 macrophages.	Polysaccharides	20-35	dedicator of cyto-kinesis 3	Mus musculus	37-40
32243763-5	2020	The host"s conversion of MUC2 to the outer mucus layer allows bacteria to degrade the mucin glycans and recover the energy content that is then shared with the host.	Polysaccharides	92-99	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	25-29
32243763-5	2020	The host"s conversion of MUC2 to the outer mucus layer allows bacteria to degrade the mucin glycans and recover the energy content that is then shared with the host.	Polysaccharides	92-99	LOC100508689	Homo sapiens	86-91
32559193-8	2020	This dramatic difference in the number of sialylated glycans between hosts was confirmed by analysis of PNGase F-released glycans using MALDI-ToF MS.	Polysaccharides	53-60	N-glycanase 1	Homo sapiens	104-110
32559193-8	2020	This dramatic difference in the number of sialylated glycans between hosts was confirmed by analysis of PNGase F-released glycans using MALDI-ToF MS.	Polysaccharides	122-129	N-glycanase 1	Homo sapiens	104-110
32396007-4	2020	In the presence of MFGM-10 (5 g/L) and bile (0.5%), there were less complex polysaccharides in the media and less capsular polysaccharides associated with the LGG cells compared to the bile exposure alone (p < 0.05).	Polysaccharides	76-91	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	19-23
32974605-9	2020	There are 11 glycosylated asparagine sequons of the human LAMP1 but only nine were assigned a sialylated glycan cap to mediate the LASV GP-C and LAMP1 interaction having exceeded a recommended glycosylation threshold of 0.5.	Polysaccharides	105-111	glycophorin C (Gerbich blood group)	Homo sapiens	136-140
32974605-9	2020	There are 11 glycosylated asparagine sequons of the human LAMP1 but only nine were assigned a sialylated glycan cap to mediate the LASV GP-C and LAMP1 interaction having exceeded a recommended glycosylation threshold of 0.5.	Polysaccharides	105-111	lysosomal associated membrane protein 1	Homo sapiens	145-150
32974605-10	2020	Therefore, the sialylated glycans of the human LAMP1 are a total of nine and these sialylated glycans mediate the molecular recognition between LASV and LAMP1.	Polysaccharides	26-33	lysosomal associated membrane protein 1	Homo sapiens	47-52
32974605-10	2020	Therefore, the sialylated glycans of the human LAMP1 are a total of nine and these sialylated glycans mediate the molecular recognition between LASV and LAMP1.	Polysaccharides	26-33	lysosomal associated membrane protein 1	Homo sapiens	153-158
32974605-10	2020	Therefore, the sialylated glycans of the human LAMP1 are a total of nine and these sialylated glycans mediate the molecular recognition between LASV and LAMP1.	Polysaccharides	94-101	lysosomal associated membrane protein 1	Homo sapiens	47-52
32974605-10	2020	Therefore, the sialylated glycans of the human LAMP1 are a total of nine and these sialylated glycans mediate the molecular recognition between LASV and LAMP1.	Polysaccharides	94-101	lysosomal associated membrane protein 1	Homo sapiens	153-158
32974605-12	2020	Further studies and the clinical trial of this predictive model on the sialylated glycans of LAMP1 will facilitate the understanding of the LASV micropinocytosis process in host cells.	Polysaccharides	82-89	lysosomal associated membrane protein 1	Homo sapiens	93-98
32438810-2	2020	In this work, we provide in-depth structural information on the glycan structures of known whey glycoproteins, namely lactoferrin, lactoperoxidase, alpha-lactalbumin, immunoglobulin-G (IgG) and glycosylation dependent cellular adhesion molecule 1 (GlyCAM-1, PP3).	Polysaccharides	64-70	lactotransferrin	Bos taurus	118-129
32396007-4	2020	In the presence of MFGM-10 (5 g/L) and bile (0.5%), there were less complex polysaccharides in the media and less capsular polysaccharides associated with the LGG cells compared to the bile exposure alone (p < 0.05).	Polysaccharides	123-138	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	19-23
32438810-2	2020	In this work, we provide in-depth structural information on the glycan structures of known whey glycoproteins, namely lactoferrin, lactoperoxidase, alpha-lactalbumin, immunoglobulin-G (IgG) and glycosylation dependent cellular adhesion molecule 1 (GlyCAM-1, PP3).	Polysaccharides	64-70	glycosylation dependent cell adhesion molecule 1	Bos taurus	194-246
32441515-4	2020	Collision energy (CE) is a crucial instrument parameter that can be exploited to improve structural resolution because different link-ages of glycan units show different stability under CID/HCD fragmentation.	Polysaccharides	142-148	DIH1	Homo sapiens	190-193
32438810-2	2020	In this work, we provide in-depth structural information on the glycan structures of known whey glycoproteins, namely lactoferrin, lactoperoxidase, alpha-lactalbumin, immunoglobulin-G (IgG) and glycosylation dependent cellular adhesion molecule 1 (GlyCAM-1, PP3).	Polysaccharides	64-70	glycosylation dependent cell adhesion molecule 1	Bos taurus	248-256
32438810-4	2020	We identified specific signature glycans for these main proteins; Lactoferrin contributes oligomannose-type glycans, while IgG carries fucosylated di-antennary glycans with Gal-beta(1,4)GlcNAc (LacNAc) motifs.	Polysaccharides	33-40	lactotransferrin	Bos taurus	66-77
32438810-4	2020	We identified specific signature glycans for these main proteins; Lactoferrin contributes oligomannose-type glycans, while IgG carries fucosylated di-antennary glycans with Gal-beta(1,4)GlcNAc (LacNAc) motifs.	Polysaccharides	108-115	lactotransferrin	Bos taurus	66-77
32438810-4	2020	We identified specific signature glycans for these main proteins; Lactoferrin contributes oligomannose-type glycans, while IgG carries fucosylated di-antennary glycans with Gal-beta(1,4)GlcNAc (LacNAc) motifs.	Polysaccharides	108-115	lactotransferrin	Bos taurus	66-77
31756475-1	2020	A neutral polysaccharide WM-NP-60 was successfully isolated and purified from a phytopathogenic fungus Sporisorium reilianum (Fries).	Polysaccharides	10-24	glyoxylate reductase 1 homolog	Homo sapiens	28-33
31756475-3	2020	WM-NP-60 was a water-soluble polysaccharide.	Polysaccharides	29-43	glyoxylate reductase 1 homolog	Homo sapiens	3-8
32112840-0	2020	Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro.	Polysaccharides	11-25	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
32294591-6	2020	EAB-0.1 had a 50% higher electroactivity per biomass and a 20% thinner thickness than EAB-1.0, which was partly due to the 54% decrease of insulative polysaccharide in biofilm.	Polysaccharides	150-164	EYA transcriptional coactivator and phosphatase 2	Homo sapiens	86-91
32112840-0	2020	Astragalus polysaccharide exerts anti-Parkinson via activating the PI3K/AKT/mTOR pathway to increase cellular autophagy level in vitro.	Polysaccharides	11-25	mechanistic target of rapamycin kinase	Rattus norvegicus	76-80
32531147-0	2020	Protein-Bound Polysaccharides from Coriolus Versicolor Induce RIPK1/RIPK3/MLKL-Mediated Necroptosis in ER-Positive Breast Cancer and Amelanotic Melanoma Cells.	Polysaccharides	14-29	receptor interacting serine/threonine kinase 1	Homo sapiens	62-67
32378902-5	2020	In addition, overexpression of FUT8 resulted in altered glycans on select EV-derived glycoproteins.	Polysaccharides	56-63	fucosyltransferase 8	Homo sapiens	31-35
32531147-0	2020	Protein-Bound Polysaccharides from Coriolus Versicolor Induce RIPK1/RIPK3/MLKL-Mediated Necroptosis in ER-Positive Breast Cancer and Amelanotic Melanoma Cells.	Polysaccharides	14-29	receptor interacting serine/threonine kinase 3	Homo sapiens	68-73
32531147-0	2020	Protein-Bound Polysaccharides from Coriolus Versicolor Induce RIPK1/RIPK3/MLKL-Mediated Necroptosis in ER-Positive Breast Cancer and Amelanotic Melanoma Cells.	Polysaccharides	14-29	mixed lineage kinase domain like pseudokinase	Homo sapiens	74-78
32545492-0	2020	Erratum: Moreira, J., et al., Spin-Coated Polysaccharide-Based Multilayered Freestanding Films with Adhesive and Bioactive Moieties.	Polysaccharides	42-56	spindlin 1	Homo sapiens	30-34
32168410-3	2020	OBJECTIVE: To reveal the glycan structures linked to FXIII-B, to design a method for deglycosylating the native protein, to find out if deglycosylation influences the dimeric structure of FXIII-B and its clearance from the circulation.	Polysaccharides	25-31	coagulation factor XIII B chain	Homo sapiens	53-60
32241449-2	2020	Multistage mass spectrometry (MSn) has become the primary method for glycan structural analysis.	Polysaccharides	69-75	moesin	Homo sapiens	30-33
32241449-4	2020	We have previously proposed the concept and designed the approach of glycan intelligent precursor selection (GIPS) to guide MSn experiments, but its use in N-glycans is not straightforward as some N-glycans are of high similarity in branching patterns.	Polysaccharides	69-75	moesin	Homo sapiens	124-127
32626520-11	2020	There was a positive correlation between LCA-binding glycans and CD147 expression in clinical samples.	Polysaccharides	53-60	basigin (Ok blood group)	Homo sapiens	65-70
32072477-3	2020	METHODS: A panel of highly sensitive and orthogonal methods, including a novel Fc gamma receptor IIIa (FcgammaRIIIa) affinity chromatography technique that enables quantitative comparison of glycan effects on effector function, was developed for the assessment.	Polysaccharides	191-197	Fc gamma receptor IIIa	Homo sapiens	79-101
32072477-3	2020	METHODS: A panel of highly sensitive and orthogonal methods, including a novel Fc gamma receptor IIIa (FcgammaRIIIa) affinity chromatography technique that enables quantitative comparison of glycan effects on effector function, was developed for the assessment.	Polysaccharides	191-197	Fc gamma receptor IIIa	Homo sapiens	103-115
32222873-6	2020	We further discovered that H-cKO mice have a profound shift toward effector/memory T cells even among unchallenged mice, and that macrophages from both the liver and spleen expressed the inhibitory and alpha2,6-sialic acid-specific glycan binding molecule CD22.	Polysaccharides	232-238	CD22 antigen	Mus musculus	256-260
32337831-0	2020	Polysaccharides from Dicliptera chinensis ameliorate liver disturbance by regulating TLR-4/NF-kappaB and AMPK/Nrf2 signalling pathways.	Polysaccharides	0-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	110-114
32337831-1	2020	The purpose of this study was to alleviate liver disturbance by applying polysaccharides from Dicliptera chinensis (DCP) to act on the adenosine monophosphate-activated protein kinase/ nuclear factor erythroid 2-related factor 2 (AMPK/ Nrf2) oxidative stress pathway and the Toll-like receptor 4 (TLR-4)/ nuclear factor kappa-B (NF-kappaB) inflammatory pathway and to establish an in vivo liver disturbance model using male C57BL/6J and TLR-4 knockout (-/- ) mice.	Polysaccharides	73-88	nuclear factor, erythroid derived 2, like 2	Mus musculus	236-240
32168410-13	2020	CONCLUSION: Characterization of the glycan moieties attached to FXIII-B is reported for the first time.	Polysaccharides	36-42	coagulation factor XIII B chain	Homo sapiens	64-71
32168410-15	2020	The associated glycan structure is not required for FXIII-B dimer formation, but it very likely prolongs the half-life of FXIII-B in the plasma.	Polysaccharides	15-21	coagulation factor XIII B chain	Homo sapiens	122-129
32238583-6	2020	Genomic analysis of the phage resistant mutant strain E. coli K12-R and complementation tests indicated that HepI of the inner core of polysaccharide acted as the second receptor recognized by phage Bp7 and was essential for successful phage infection.	Polysaccharides	135-149	BP7	Homo sapiens	199-202
32518821-3	2020	The exceptionally long (60 residues) third complementarity-determining region of the heavy chain (CDR H3) of NC-Cow1 forms a mini domain (knob) on an extended stalk that navigates through the dense glycan shield on Env to target a small footprint on the gp120 CD4 receptor binding site with no contact of the other CDRs to the rest of the Env trimer.	Polysaccharides	198-204	endogenous retrovirus group PABLB member 1 Env polyprotein	Bos taurus	215-218
32321762-4	2020	Here, we report GPI-glycan structures of human PrPC isolated from human brain and from brains of a knock-in mouse model in which the mouse prion protein (Prnp) gene was replaced with the human PRNP gene.	Polysaccharides	20-26	prion protein	Homo sapiens	47-51
32321762-4	2020	Here, we report GPI-glycan structures of human PrPC isolated from human brain and from brains of a knock-in mouse model in which the mouse prion protein (Prnp) gene was replaced with the human PRNP gene.	Polysaccharides	20-26	prion protein	Homo sapiens	154-158
32321762-4	2020	Here, we report GPI-glycan structures of human PrPC isolated from human brain and from brains of a knock-in mouse model in which the mouse prion protein (Prnp) gene was replaced with the human PRNP gene.	Polysaccharides	20-26	prion protein	Homo sapiens	193-197
32321762-8	2020	In summary, we report the GPI-glycan structure of human PrPC, including the omega-site amino acid for GPI attachment and the sialic acid linkage type.	Polysaccharides	30-36	prion protein	Homo sapiens	56-60
32528292-0	2020	Polyporus Polysaccharide Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing Myofibroblast Differentiation via TGF-beta/Smad2/3 Pathway.	Polysaccharides	10-24	transforming growth factor alpha	Mus musculus	123-131
32518821-3	2020	The exceptionally long (60 residues) third complementarity-determining region of the heavy chain (CDR H3) of NC-Cow1 forms a mini domain (knob) on an extended stalk that navigates through the dense glycan shield on Env to target a small footprint on the gp120 CD4 receptor binding site with no contact of the other CDRs to the rest of the Env trimer.	Polysaccharides	198-204	endogenous retrovirus group PABLB member 1 Env polyprotein	Bos taurus	339-342
32528292-0	2020	Polyporus Polysaccharide Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing Myofibroblast Differentiation via TGF-beta/Smad2/3 Pathway.	Polysaccharides	10-24	SMAD family member 2	Mus musculus	132-139
32466336-5	2020	Modification of PUR, e.g., with polysaccharide of natural origin (chitosan, Chit), should have a positive effect on their functional properties and degradability in the natural environment.	Polysaccharides	32-46	chitinase 1	Homo sapiens	76-80
32134631-4	2020	Here we evaluate the capacity of norbornene polymers displaying galactose and/or fucose to block CTB binding to immobilized protein-linked glycan structures and also to primary human and murine small intestine epithelial cells (SI ECs).	Polysaccharides	139-145	phosphate cytidylyltransferase 1B, choline	Homo sapiens	97-100
32429122-1	2020	Stabilin-2/HARE is the primary clearance receptor for circulating hyaluronan (HA), a polysaccharide found in the extracellular matrix (ECM) of metazoans.	Polysaccharides	85-99	stabilin 2	Homo sapiens	0-10
32429122-1	2020	Stabilin-2/HARE is the primary clearance receptor for circulating hyaluronan (HA), a polysaccharide found in the extracellular matrix (ECM) of metazoans.	Polysaccharides	85-99	stabilin 2	Homo sapiens	11-15
32083833-0	2020	Stimuli-responsive polysaccharide enveloped liposome for targeting and penetrating delivery of survivin-shRNA into breast tumor.	Polysaccharides	19-33	baculoviral IAP repeat-containing 5	Mus musculus	95-103
32083833-3	2020	Herein we developed a novel stimuli-responsive polysaccharide enveloped liposome carrier, which was constructed by layer-by-layer depositing redox-sensitive amphiphilic chitosan (CS) and hyaluronic acid (HA) onto the liposome and then loading IAP inhibitor survivin-shRNA gene and permeation promoter hyaluronidase (HAase) sequentially.	Polysaccharides	47-61	baculoviral IAP repeat-containing 5	Mus musculus	257-265
32670555-7	2020	Meanwhile, the polysaccharides enhanced telomerase activity while reduced p16 protein expression of the brain mitochondria.	Polysaccharides	15-30	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	74-77
32477379-4	2020	Transcriptome analysis revealed that the genes regulating CW pectin, cellulose, and hemicellulose polysaccharide concentrations in Tor-1 differed significantly from those in Ph2-23.	Polysaccharides	98-112	ARM repeat superfamily protein	Arabidopsis thaliana	131-136
32437807-2	2020	In the present work, a novel acid-soluble polysaccharide (GFAP) was successfully isolated from G. frondosa under room temperature and hydrochloric acid solution treatment.	Polysaccharides	42-56	glial fibrillary acidic protein	Mus musculus	58-62
32264668-8	2020	To illustrate the glycan-dependent binding of E-selectin, a central molecule in cell migration, to its glycosylated ligands expressed on myeloid-leukemic cells in flow, the FMCR assay was used to analyze E-selectin-Ligand interactions following the addition (fucosyltransferase-treatment) or removal (deglycosylation) of key glycans on the flowing cells.	Polysaccharides	18-24	selectin E	Homo sapiens	46-56
32279507-1	2020	Non-covalent binding of proteins to glycans is amazingly selective to the isoforms of carbohydrates, including alpha/beta anomers that co-exist in solution.	Polysaccharides	36-43	amyloid beta precursor protein	Homo sapiens	111-121
32376914-1	2020	The alpha-2,8-linked form of the polysaccharide polysialic acid (PSA) has widespread implications in physiological and pathological processes, ranging from neurological development to disease progression.	Polysaccharides	33-47	glycoprotein hormone subunit alpha 2	Homo sapiens	4-11
32264668-8	2020	To illustrate the glycan-dependent binding of E-selectin, a central molecule in cell migration, to its glycosylated ligands expressed on myeloid-leukemic cells in flow, the FMCR assay was used to analyze E-selectin-Ligand interactions following the addition (fucosyltransferase-treatment) or removal (deglycosylation) of key glycans on the flowing cells.	Polysaccharides	18-24	selectin E	Homo sapiens	204-214
32264668-8	2020	To illustrate the glycan-dependent binding of E-selectin, a central molecule in cell migration, to its glycosylated ligands expressed on myeloid-leukemic cells in flow, the FMCR assay was used to analyze E-selectin-Ligand interactions following the addition (fucosyltransferase-treatment) or removal (deglycosylation) of key glycans on the flowing cells.	Polysaccharides	325-332	selectin E	Homo sapiens	46-56
32378684-0	2020	Polysaccharides from Enteromorpha prolifera protect against carbon tetrachloride-induced acute liver injury in mice via activation of Nrf2/HO-1 signaling, and suppression of oxidative stress, inflammation and apoptosis.	Polysaccharides	0-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	134-138
32387359-1	2020	Polysaccharide was derived from Pueraria lobata (PPL) which was considered as one of the traditional Chinese medicinal and edible herbs.	Polysaccharides	0-14	periplakin	Mus musculus	49-52
32371950-1	2020	Oligomannose-type glycans on HIV-1 gp120 form a patch that is targeted by several broadly neutralizing antibodies (bnAbs) and that therefore is of interest to vaccine design.	Polysaccharides	18-25	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	35-40
32044676-0	2020	Sustained release of TGF-beta3 from polysaccharide nanoparticles induces chondrogenic differentiation of human mesenchymal stromal cells.	Polysaccharides	36-50	transforming growth factor beta 3	Homo sapiens	21-30
32044676-3	2020	Here we developed three innovative delivery systems based on different polysaccharides in order to induce a sustained release of TGF-beta3 to mediate chondrogenesis of human mesenchymal stromal cells.	Polysaccharides	71-86	transforming growth factor beta 3	Homo sapiens	129-138
32431616-0	2020	Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer.	Polysaccharides	11-26	sirtuin 1	Homo sapiens	90-95
32431616-0	2020	Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer.	Polysaccharides	11-26	sterol regulatory element binding transcription factor 1	Homo sapiens	96-102
32378684-0	2020	Polysaccharides from Enteromorpha prolifera protect against carbon tetrachloride-induced acute liver injury in mice via activation of Nrf2/HO-1 signaling, and suppression of oxidative stress, inflammation and apoptosis.	Polysaccharides	0-15	heme oxygenase 1	Mus musculus	139-143
32360964-8	2020	This work shows that the ability of Fbg to self-assemble upon thermal treatment can be effectively used to stabilize Fbg nanoformulations inside complexes with polysaccharides.	Polysaccharides	160-175	fibrinogen beta chain	Homo sapiens	36-39
32360964-8	2020	This work shows that the ability of Fbg to self-assemble upon thermal treatment can be effectively used to stabilize Fbg nanoformulations inside complexes with polysaccharides.	Polysaccharides	160-175	fibrinogen beta chain	Homo sapiens	117-120
32475187-6	2020	Levels of 24-hour urinary microalbumin, creatinine, blood urea nitrogen, collagens I, III, and IV, alpha-smooth muscle actin, transforming growth factor-beta1, and Smad3 in Astragalus polysaccharide groups (all doses) were significantly lower than those in the model group.	Polysaccharides	184-198	SMAD family member 3	Rattus norvegicus	164-169
32221039-7	2020	Removal of Fab-linked glycans in RA056/11.23.2 in the N-mutant counterpart resulted in 90% reduction in immunoreactivity to cit-H2B.	Polysaccharides	22-29	FA complementation group B	Homo sapiens	11-14
32475187-0	2020	Astragalus polysaccharides protect renal function and affect the TGF-beta/Smad signaling pathway in streptozotocin-induced diabetic rats.	Polysaccharides	11-26	transforming growth factor alpha	Rattus norvegicus	65-73
32431673-5	2020	Importantly, SERINC5 co-localized with LHB proteins in the Golgi apparatus, which is important for glycan processing and transport.	Polysaccharides	99-105	serine incorporator 5	Homo sapiens	13-20
32422500-0	2020	Polysaccharides from Opuntia milpa alta alleviate alloxan-induced INS-1 cells apoptosis via reducing oxidative stress and upregulating Nrf2 expression.	Polysaccharides	0-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	135-139
32169960-3	2020	Members of the Cellulose synthases (CESA) and Cellulose Synthase-Like (CSL) families encode glycosyltransferases that synthesize the beta-1,4-linked glycan backbones of cellulose and most hemicellulosic polysaccharides that comprise plant cell walls.	Polysaccharides	203-218	chorionic somatomammotropin hormone like 1	Homo sapiens	46-69
32169960-3	2020	Members of the Cellulose synthases (CESA) and Cellulose Synthase-Like (CSL) families encode glycosyltransferases that synthesize the beta-1,4-linked glycan backbones of cellulose and most hemicellulosic polysaccharides that comprise plant cell walls.	Polysaccharides	203-218	chorionic somatomammotropin hormone like 1	Homo sapiens	71-74
32365793-10	2020	When challenged with E. coli polysaccharides, in HGF cells co-exposed to TE and LE, a reduction in the release of proinflammatory cytokines (IL-8, IL-6 and IL-1beta) was observed.	Polysaccharides	29-44	hepatocyte growth factor	Homo sapiens	49-52
32431673-5	2020	Importantly, SERINC5 co-localized with LHB proteins in the Golgi apparatus, which is important for glycan processing and transport.	Polysaccharides	99-105	luteinizing hormone subunit beta	Homo sapiens	39-42
32426269-8	2020	We found that several sialylated but not core fucosylated tri-antennary glycans were uniquely increased in low AFP level of HCC tumors, while many core fucosylated bi-antennary or hybrid glycans as well as bisecting glycans were uniquely increased in high AFP tumors.	Polysaccharides	72-79	alpha fetoprotein	Homo sapiens	111-114
32301325-11	2020	The enzymatic glyco-modulation of Muc gels appears as a useful tool to help understand the biological functions of specific glycans on mucins which can further inform on their use in various biomedical applications.	Polysaccharides	124-131	MUC	Bos taurus	34-37
31991210-8	2020	To check a potential function of the enzymes for the degradation of mucosal glycan structures, porcine stomach mucin was applied as a model substrate.	Polysaccharides	76-82	LOC100508689	Homo sapiens	111-116
32271008-3	2020	Here, we developed a method based on chemoenzymatic glycan engineering to investigate the possible involvement of alpha1-2-fucosides in IVA infections.	Polysaccharides	52-58	BCL2 related protein A1	Homo sapiens	114-122
32111587-5	2020	Dep6 exhibited strong hydrolase activity across wide pH (pH 4-8) and temperature (20-60 C) ranges, and degraded polysaccharides on the surface of STEC strain HB10.	Polysaccharides	112-127	DEP domain containing MTOR interacting protein	Homo sapiens	0-4
32132174-3	2020	However, no method is currently available for measuring beta-1,6-glucan, another primary beta-glucan structure of fungal polysaccharides.	Polysaccharides	121-136	immunoglobulin kappa variable 3-31 (pseudogene)	Homo sapiens	56-64
32351949-5	2020	C. jejuni oligosaccharyltransferase PglB was used to transfer the terminally sialylated glycan onto a glyco-recognition sequence in the tenth type III cell adhesion module of human fibronectin.	Polysaccharides	88-94	fibronectin 1	Homo sapiens	181-192
32154706-1	2020	Capillary gel electrophoresis with laser-induced fluorescence detection (CGE-LIF) has become a key method in high-throughput glycan analysis.	Polysaccharides	125-131	LIF interleukin 6 family cytokine	Homo sapiens	77-80
32295166-2	2020	Here, we propose an algorithm to reduce the intermediate zone and improve the diagnostic performance of screening for advanced liver fibrosis by incorporating Mac-2-binding protein glycan isomer (M2BPGi) into a FIB-4 based screening strategy in an average risk group.	Polysaccharides	181-187	galectin 3 binding protein	Homo sapiens	159-180
32295194-4	2020	PBP which contains the majority of sulfated polysaccharides based on fucoidan, showed outstanding extracellular ROS scavenging potential against H2O2.	Polysaccharides	44-59	phosphatidylethanolamine binding protein 1	Danio rerio	0-3
32105056-3	2020	Cetuximab harbors four glycans per molecule, two on each heavy chain, of which the Fab glycans have been reported to be complex and multiply sialylated.	Polysaccharides	23-30	FA complementation group B	Homo sapiens	83-86
32154706-11	2020	The new dyes are expected to cross-validate and increase the glycan identification precision in CGE-LIF and help to reveal "heavy" glycans, yet undetectable with the APTS label.	Polysaccharides	61-67	LIF interleukin 6 family cytokine	Homo sapiens	100-103
32162920-0	2020	Alterations in the Glycan Profile of Mouse Transferrin: New Insights in Collagen-Induced Arthritis.	Polysaccharides	19-25	transferrin	Mus musculus	43-54
32265336-11	2020	Through detailed biochemical and protein structural analysis, we observed an unexpected diversity in the substrate specificity of PUL glycosidases and glycan-binding proteins with regard to beta(1,3)-glucan linkage and branching patterns.	Polysaccharides	151-157	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	190-198
32205440-7	2020	We found massive oncogene-induced changes to the glycoproteome and differential increases in complex hybrid glycans, especially for KRAS and HER2 oncogenes.	Polysaccharides	108-115	KRAS proto-oncogene, GTPase	Homo sapiens	132-136
32205440-7	2020	We found massive oncogene-induced changes to the glycoproteome and differential increases in complex hybrid glycans, especially for KRAS and HER2 oncogenes.	Polysaccharides	108-115	erb-b2 receptor tyrosine kinase 2	Homo sapiens	141-145
32162920-1	2020	Transferrin purification from mice serum samples by immunoaffinity chromatography (IAC) was optimized in order to study the possible modifications occurring in its glycans in collagen-induced arthritis (CIA) samples.	Polysaccharides	164-171	transferrin	Mus musculus	0-11
32162920-3	2020	Afterward, a relative quantification of mouse transferrin (mTf) glycan isomers using [12C6]/[13C6]-aniline was used to unequivocally detect alterations in the glycan profile of CIA mice.	Polysaccharides	64-70	transferrin	Mus musculus	46-57
32162920-3	2020	Afterward, a relative quantification of mouse transferrin (mTf) glycan isomers using [12C6]/[13C6]-aniline was used to unequivocally detect alterations in the glycan profile of CIA mice.	Polysaccharides	159-165	transferrin	Mus musculus	46-57
32171073-6	2020	MCPPec or AGPTFA could not further intensify the adhesion reducing effect of galectin-3 knockdown, indicating that these plant derived polysaccharides are able to inhibit PDAC cell adhesion to liver endothelial cells in a galectin-3 dependent manner.	Polysaccharides	135-150	galectin 3	Homo sapiens	222-232
32085963-5	2020	Immunoassay results showed that the five polysaccharides not only promoted the growth of RAW264.7 cells but also stimulated their endocytic/pinocytosis activity and released NO, TNF, IL-6 cytokines, especially BRP.	Polysaccharides	41-56	tumor necrosis factor	Mus musculus	178-181
32085963-5	2020	Immunoassay results showed that the five polysaccharides not only promoted the growth of RAW264.7 cells but also stimulated their endocytic/pinocytosis activity and released NO, TNF, IL-6 cytokines, especially BRP.	Polysaccharides	41-56	interleukin 6	Mus musculus	183-187
32085963-5	2020	Immunoassay results showed that the five polysaccharides not only promoted the growth of RAW264.7 cells but also stimulated their endocytic/pinocytosis activity and released NO, TNF, IL-6 cytokines, especially BRP.	Polysaccharides	41-56	growth differentiation factor 5	Mus musculus	210-213
32413678-2	2020	Recent studies of measles virus haemagglutinin (MeV-H) and its receptor, including crystallographic and electron microscopic structural analyses combined with functional assays, have revealed how the MeV-H protein recognizes its cognate receptors, SLAM and Nectin-4, and how the glycan shield ensures effective vaccination.	Polysaccharides	279-285	mev-h	None	48-53
31273092-2	2020	Glycoprotein Ibalpha contains many glycans, capped by sialic acid.	Polysaccharides	35-42	glycoprotein Ib platelet subunit alpha	Homo sapiens	0-20
31900725-4	2020	The glycans mediated binding to these cells was effectively blocked by mucin and fetuin, exhibiting 97% and 94% inhibition respectively.	Polysaccharides	4-11	LOC100508689	Homo sapiens	71-76
32413678-2	2020	Recent studies of measles virus haemagglutinin (MeV-H) and its receptor, including crystallographic and electron microscopic structural analyses combined with functional assays, have revealed how the MeV-H protein recognizes its cognate receptors, SLAM and Nectin-4, and how the glycan shield ensures effective vaccination.	Polysaccharides	279-285	signaling lymphocytic activation molecule family member 1	Homo sapiens	248-252
31958555-3	2020	In the present study, three purified polysaccharides (LCP-1, LCP-2, and LCP-3) were obtained from Leccinum crocipodium (Letellier.)	Polysaccharides	37-52	lymphocyte cytosolic protein 1	Mus musculus	54-59
31958555-9	2020	For the in vitro immunomodulatory experiments demonstrated that three purified polysaccharides could enhance immunomodulatory activities on macrophage RAW 264.7 cells, moreover, LCP-2 and LCP-3 showed stronger immunomodulatory activity than LCP-1.	Polysaccharides	79-94	lymphocyte cytosolic protein 2	Mus musculus	178-183
32413678-2	2020	Recent studies of measles virus haemagglutinin (MeV-H) and its receptor, including crystallographic and electron microscopic structural analyses combined with functional assays, have revealed how the MeV-H protein recognizes its cognate receptors, SLAM and Nectin-4, and how the glycan shield ensures effective vaccination.	Polysaccharides	279-285	nectin cell adhesion molecule 4	Homo sapiens	257-265
31958555-9	2020	For the in vitro immunomodulatory experiments demonstrated that three purified polysaccharides could enhance immunomodulatory activities on macrophage RAW 264.7 cells, moreover, LCP-2 and LCP-3 showed stronger immunomodulatory activity than LCP-1.	Polysaccharides	79-94	lymphocyte cytosolic protein 1	Mus musculus	241-246
32086870-2	2020	After escape from a damaged Salmonella-containing vacuole (SCV) exposing luminal glycans that bind to Galectin-8, the host cell ubiquitination machinery deposits a dense layer of ubiquitin around the cytosolic bacteria.	Polysaccharides	81-88	galectin 8	Homo sapiens	102-112
32175536-0	2020	Longan pulp polysaccharide protects against cyclophosphamide-induced immunosuppression in mice by promoting intestinal secretory IgA synthesis.	Polysaccharides	12-26	immunoglobulin heavy constant alpha	Mus musculus	129-132
32234060-3	2020	An asparagine-linked glycan on the "glycan loop" (GL) of the ZIKV envelope protein protects the functionally important "fusion loop" on the opposite E subunit in the dimer, and EDE antibodies have been shown to bind to both of these loops.	Polysaccharides	21-27	endogenous retrovirus group K member 6, envelope	Homo sapiens	66-82
32435405-5	2020	Herein, we describe the structure-based design and synthesis of new glycan-containing PF-543 analogues and we demonstrate their efficiency in a TGFbeta1-induced pro-fibrotic assay.	Polysaccharides	68-74	latent transforming growth factor beta binding protein 1	Homo sapiens	144-152
32221390-2	2020	PGM1 catalyzes the bi-directional interconversion between alpha-D-glucose 1-phosphate (G1P) and alpha-D-glucose 6-phosphate (G6P), a reaction that is essential for normal carbohydrate metabolism and also important in the cytoplasmic biosynthesis of nucleotide sugars needed for glycan biosynthesis.	Polysaccharides	278-284	phosphoglucomutase 1	Homo sapiens	0-4
32273875-0	2020	Removal of Mannose-Ending Glycan at Asn2118 Abrogates FVIII Presentation by Human Monocyte-Derived Dendritic Cells.	Polysaccharides	26-32	coagulation factor VIII	Homo sapiens	54-59
32273875-9	2020	Further investigations in preclinical models of hemophilia A closer to humans are needed to decipher the exact role of mannose-ending glycans in factor VIII immunogenicity.	Polysaccharides	134-141	coagulation factor VIII	Mus musculus	145-156
32308723-6	2020	The results showed that 5 selected polysaccharides, except BBPS, significantly (P < 0.05) and dose-dependently increased M1 (IL-1beta + IL-6 + TNF-alpha)/M2 (IL-10) cytokine secretion ratios by macrophages in the absence of LPS, suggesting that four selected polysaccharides have M1 polarization property.	Polysaccharides	35-50	interleukin 10	Homo sapiens	158-163
32308547-1	2020	A polysaccharide isolated from the radix of Astragalus membranaceus, called PG2, used in traditional Chinese medicine, with potential hematopoiesis inducing and immunomodulation activities.	Polysaccharides	2-16	delta like non-canonical Notch ligand 1	Homo sapiens	76-79
32308723-6	2020	The results showed that 5 selected polysaccharides, except BBPS, significantly (P < 0.05) and dose-dependently increased M1 (IL-1beta + IL-6 + TNF-alpha)/M2 (IL-10) cytokine secretion ratios by macrophages in the absence of LPS, suggesting that four selected polysaccharides have M1 polarization property.	Polysaccharides	35-50	interleukin 1 alpha	Homo sapiens	125-133
32308723-6	2020	The results showed that 5 selected polysaccharides, except BBPS, significantly (P < 0.05) and dose-dependently increased M1 (IL-1beta + IL-6 + TNF-alpha)/M2 (IL-10) cytokine secretion ratios by macrophages in the absence of LPS, suggesting that four selected polysaccharides have M1 polarization property.	Polysaccharides	35-50	interleukin 6	Homo sapiens	136-140
32308723-6	2020	The results showed that 5 selected polysaccharides, except BBPS, significantly (P < 0.05) and dose-dependently increased M1 (IL-1beta + IL-6 + TNF-alpha)/M2 (IL-10) cytokine secretion ratios by macrophages in the absence of LPS, suggesting that four selected polysaccharides have M1 polarization property.	Polysaccharides	35-50	TNF receptor superfamily member 8	Homo sapiens	165-173
32308723-6	2020	The results showed that 5 selected polysaccharides, except BBPS, significantly (P < 0.05) and dose-dependently increased M1 (IL-1beta + IL-6 + TNF-alpha)/M2 (IL-10) cytokine secretion ratios by macrophages in the absence of LPS, suggesting that four selected polysaccharides have M1 polarization property.	Polysaccharides	35-50	tumor necrosis factor	Homo sapiens	143-152
32308723-7	2020	However, all of 5 selected polysaccharides significantly (P < 0.05) decreased proinflammatory (IL-1beta + IL-6 + TNF-alpha)/anti-inflammatory (IL-10) cytokine secretion ratios by LPS-stimulated macrophages, exhibiting that all of the 5 selected polysaccharides, particularly GSPS, have anti-inflammatory potential.	Polysaccharides	27-42	interleukin 1 alpha	Homo sapiens	95-103
32308723-7	2020	However, all of 5 selected polysaccharides significantly (P < 0.05) decreased proinflammatory (IL-1beta + IL-6 + TNF-alpha)/anti-inflammatory (IL-10) cytokine secretion ratios by LPS-stimulated macrophages, exhibiting that all of the 5 selected polysaccharides, particularly GSPS, have anti-inflammatory potential.	Polysaccharides	27-42	interleukin 6	Homo sapiens	106-110
32308723-7	2020	However, all of 5 selected polysaccharides significantly (P < 0.05) decreased proinflammatory (IL-1beta + IL-6 + TNF-alpha)/anti-inflammatory (IL-10) cytokine secretion ratios by LPS-stimulated macrophages, exhibiting that all of the 5 selected polysaccharides, particularly GSPS, have anti-inflammatory potential.	Polysaccharides	27-42	tumor necrosis factor	Homo sapiens	113-122
32308723-7	2020	However, all of 5 selected polysaccharides significantly (P < 0.05) decreased proinflammatory (IL-1beta + IL-6 + TNF-alpha)/anti-inflammatory (IL-10) cytokine secretion ratios by LPS-stimulated macrophages, exhibiting that all of the 5 selected polysaccharides, particularly GSPS, have anti-inflammatory potential.	Polysaccharides	27-42	interleukin 10	Homo sapiens	143-148
32308723-7	2020	However, all of 5 selected polysaccharides significantly (P < 0.05) decreased proinflammatory (IL-1beta + IL-6 + TNF-alpha)/anti-inflammatory (IL-10) cytokine secretion ratios by LPS-stimulated macrophages, exhibiting that all of the 5 selected polysaccharides, particularly GSPS, have anti-inflammatory potential.	Polysaccharides	27-42	TNF receptor superfamily member 8	Homo sapiens	150-158
32308723-7	2020	However, all of 5 selected polysaccharides significantly (P < 0.05) decreased proinflammatory (IL-1beta + IL-6 + TNF-alpha)/anti-inflammatory (IL-10) cytokine secretion ratios by LPS-stimulated macrophages, exhibiting that all of the 5 selected polysaccharides, particularly GSPS, have anti-inflammatory potential.	Polysaccharides	245-260	TNF receptor superfamily member 8	Homo sapiens	150-158
32215724-1	2020	A biocompatible natural polysaccharide (PSP001) isolated from the fruit rind of Punica granatum was conjugated with L-cysteine (Y) to be used as a skeleton for the fabrication of fluorescent gold nanoclusters (AuNCs) represented as PSP-Y-AuNCs.	Polysaccharides	24-38	persephin	Mus musculus	40-43
32215724-10	2020	Graphical abstract Fluorescent gold nanoclusters (PSP-Y-AuNCs) fabricated using a non-toxic natural polysaccharide (PSP001) demonstrated pH sensitive fluorescence emission pattern.	Polysaccharides	100-114	persephin	Mus musculus	50-53
31884067-0	2020	Region-specific upregulation of HNK-1 glycan in the PRMT1-deficient brain.	Polysaccharides	38-44	beta-1,3-glucuronyltransferase 1	Homo sapiens	32-37
32208455-8	2020	The presence of two distinct binding sites for Leb and non-Leb HBGA glycans in the P[8] and P[4] VP8* domains suggests host-pathogen co-evolution under structural and functional adaptation of RV pathogens to host glycan polymorphisms.	Polysaccharides	68-75	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	59-62
32208455-8	2020	The presence of two distinct binding sites for Leb and non-Leb HBGA glycans in the P[8] and P[4] VP8* domains suggests host-pathogen co-evolution under structural and functional adaptation of RV pathogens to host glycan polymorphisms.	Polysaccharides	68-75	hemoglobin subunit gamma 1	Homo sapiens	63-67
32208455-8	2020	The presence of two distinct binding sites for Leb and non-Leb HBGA glycans in the P[8] and P[4] VP8* domains suggests host-pathogen co-evolution under structural and functional adaptation of RV pathogens to host glycan polymorphisms.	Polysaccharides	68-74	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	59-62
32208455-8	2020	The presence of two distinct binding sites for Leb and non-Leb HBGA glycans in the P[8] and P[4] VP8* domains suggests host-pathogen co-evolution under structural and functional adaptation of RV pathogens to host glycan polymorphisms.	Polysaccharides	68-74	hemoglobin subunit gamma 1	Homo sapiens	63-67
32109354-2	2020	In our previous efforts, vaccinating rabbits with evolved HMP mimic glycopeptides containing Man9 resulted in an overall antibody response targeting the glycan core and linker rather than the full glycan or Manalpha1 2Man tips of Man9 glycans.	Polysaccharides	153-159	mannosidase alpha class 1A member 1	Homo sapiens	93-97
32109354-2	2020	In our previous efforts, vaccinating rabbits with evolved HMP mimic glycopeptides containing Man9 resulted in an overall antibody response targeting the glycan core and linker rather than the full glycan or Manalpha1 2Man tips of Man9 glycans.	Polysaccharides	197-203	mannosidase alpha class 1A member 1	Homo sapiens	93-97
32213234-4	2020	Chemical composition analysis of RAM showed that the main compositions were volatile oil, lactones, polysaccharides, amino acids, vitamins and resins.	Polysaccharides	100-115	CCDC26 long non-coding RNA	Homo sapiens	33-36
32231800-1	2020	Purpose: Galectin-3 (Gal-3) is a glycan-binding lectin with a debated role in cancer progression due to its various functions and patterns of expression.	Polysaccharides	33-39	galectin 3	Homo sapiens	9-19
32231800-1	2020	Purpose: Galectin-3 (Gal-3) is a glycan-binding lectin with a debated role in cancer progression due to its various functions and patterns of expression.	Polysaccharides	33-39	galectin 3	Homo sapiens	21-26
32232009-8	2020	The correlated alterations in glycosyltransferase expression and tissue glycomics were then evaluated by differential glycan profiling of a membrane N-glycoprotein, basigin, expressed in tumor and non-tumor pancreatic cells.	Polysaccharides	118-124	basigin (Ok blood group)	Homo sapiens	165-172
32232009-9	2020	The focused differential glycomic profiling for endogenous basigin derived from non-tumor and cancerous regions of PDAC tissue sections demonstrated that PDAC-relevant glycan alterations of basigin closely reflected the notable features in the disease-specific alterations in the tissue glycomes.	Polysaccharides	168-174	basigin (Ok blood group)	Homo sapiens	59-66
32232009-9	2020	The focused differential glycomic profiling for endogenous basigin derived from non-tumor and cancerous regions of PDAC tissue sections demonstrated that PDAC-relevant glycan alterations of basigin closely reflected the notable features in the disease-specific alterations in the tissue glycomes.	Polysaccharides	168-174	basigin (Ok blood group)	Homo sapiens	190-197
31973821-10	2020	These results demonstrated that core 1-derived O-glycan on podocytes is required for normal glomerular filtration and may contribute to the stable expression of podocalyxin and podoplanin.	Polysaccharides	47-55	podocalyxin-like	Mus musculus	161-172
32188725-6	2020	Furthermore, purified syndecan-1, but not syndecan-1 core protein, binds to HMGB1, suggesting that HMGB1 binds to HS polysaccharide side chains of syndecan-1.	Polysaccharides	117-131	syndecan 1	Homo sapiens	22-32
32188725-6	2020	Furthermore, purified syndecan-1, but not syndecan-1 core protein, binds to HMGB1, suggesting that HMGB1 binds to HS polysaccharide side chains of syndecan-1.	Polysaccharides	117-131	high mobility group box 1	Homo sapiens	99-104
31981485-0	2020	Identification of the epitope of 10-7G glycan antibody to recognize cancer-associated haptoglobin.	Polysaccharides	39-45	haptoglobin	Homo sapiens	86-97
31884067-0	2020	Region-specific upregulation of HNK-1 glycan in the PRMT1-deficient brain.	Polysaccharides	38-44	protein arginine methyltransferase 1	Homo sapiens	52-57
31884067-1	2020	BACKGROUND: Brains express structurally unique glycans, including human natural killer-1 (HNK-1), which participate in development and high-order functions.	Polysaccharides	47-54	beta-1,3-glucuronyltransferase 1	Homo sapiens	90-95
31884067-6	2020	RESULTS: Among several glycans, expression of HNK-1 glycan was strikingly upregulated in the PRMT1-deficient cerebellum.	Polysaccharides	23-30	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	46-51
31884067-6	2020	RESULTS: Among several glycans, expression of HNK-1 glycan was strikingly upregulated in the PRMT1-deficient cerebellum.	Polysaccharides	23-30	protein arginine N-methyltransferase 1	Mus musculus	93-98
31884067-6	2020	RESULTS: Among several glycans, expression of HNK-1 glycan was strikingly upregulated in the PRMT1-deficient cerebellum.	Polysaccharides	23-29	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	46-51
31884067-6	2020	RESULTS: Among several glycans, expression of HNK-1 glycan was strikingly upregulated in the PRMT1-deficient cerebellum.	Polysaccharides	23-29	protein arginine N-methyltransferase 1	Mus musculus	93-98
31884067-10	2020	CONCLUSIONS: Loss of arginine methylation leads to an increase in HNK-1 glycan in the developing cerebellum but not in the cerebral cortex via upregulation of the biosynthetic enzyme and carrier glycoproteins.	Polysaccharides	72-78	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	66-71
31884067-11	2020	GENERAL SIGNIFICANCE: PRMT1 is a novel regulator of HNK-1 glycan production in the cerebellum.	Polysaccharides	58-64	protein arginine N-methyltransferase 1	Mus musculus	22-27
31884067-11	2020	GENERAL SIGNIFICANCE: PRMT1 is a novel regulator of HNK-1 glycan production in the cerebellum.	Polysaccharides	58-64	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	52-57
32005975-7	2020	O-glycans on EPHA2 were modified by C1GALT1 and both S277A and T429A mutants, which are O-glycosites on EPHA2, dramatically enhanced phosphorylation of Y588, suggesting that not only overall O-glycan structures but also site-specific O-glycosylation can regulate EPHA2 activity.	Polysaccharides	0-9	EPH receptor A2	Homo sapiens	13-18
31888819-0	2020	Two novel polysaccharides from rhizomes of Cibotium barometz promote bone formation via activating the BMP2/SMAD1 signaling pathway in MC3T3-E1 cells.	Polysaccharides	10-25	bone morphogenetic protein 2	Mus musculus	103-107
31888819-0	2020	Two novel polysaccharides from rhizomes of Cibotium barometz promote bone formation via activating the BMP2/SMAD1 signaling pathway in MC3T3-E1 cells.	Polysaccharides	10-25	SMAD family member 1	Mus musculus	108-113
31532909-0	2020	Polysaccharide Oxidation by Lytic Polysaccharide Monooxygenase is Enhanced by Engineered Cellobiose Dehydrogenase.	Polysaccharides	0-14	choline dehydrogenase	Homo sapiens	89-113
30924376-0	2020	Recognition of alpha-mannan by dectin 2 is essential for onset of Kawasaki disease-like murine vasculitis induced by Candida albicans cell-wall polysaccharide.	Polysaccharides	144-158	C-type lectin domain family 4, member n	Mus musculus	31-39
32156170-3	2020	The GPI consists of the conserved core glycan, phosphatidylinositol and glycan side chains.	Polysaccharides	39-45	glucose-6-phosphate isomerase	Homo sapiens	4-7
32156170-3	2020	The GPI consists of the conserved core glycan, phosphatidylinositol and glycan side chains.	Polysaccharides	72-78	glucose-6-phosphate isomerase	Homo sapiens	4-7
32005975-7	2020	O-glycans on EPHA2 were modified by C1GALT1 and both S277A and T429A mutants, which are O-glycosites on EPHA2, dramatically enhanced phosphorylation of Y588, suggesting that not only overall O-glycan structures but also site-specific O-glycosylation can regulate EPHA2 activity.	Polysaccharides	0-9	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	36-43
32005975-7	2020	O-glycans on EPHA2 were modified by C1GALT1 and both S277A and T429A mutants, which are O-glycosites on EPHA2, dramatically enhanced phosphorylation of Y588, suggesting that not only overall O-glycan structures but also site-specific O-glycosylation can regulate EPHA2 activity.	Polysaccharides	0-9	EPH receptor A2	Homo sapiens	104-109
32005975-7	2020	O-glycans on EPHA2 were modified by C1GALT1 and both S277A and T429A mutants, which are O-glycosites on EPHA2, dramatically enhanced phosphorylation of Y588, suggesting that not only overall O-glycan structures but also site-specific O-glycosylation can regulate EPHA2 activity.	Polysaccharides	0-9	EPH receptor A2	Homo sapiens	104-109
32005975-7	2020	O-glycans on EPHA2 were modified by C1GALT1 and both S277A and T429A mutants, which are O-glycosites on EPHA2, dramatically enhanced phosphorylation of Y588, suggesting that not only overall O-glycan structures but also site-specific O-glycosylation can regulate EPHA2 activity.	Polysaccharides	0-8	EPH receptor A2	Homo sapiens	13-18
32005975-7	2020	O-glycans on EPHA2 were modified by C1GALT1 and both S277A and T429A mutants, which are O-glycosites on EPHA2, dramatically enhanced phosphorylation of Y588, suggesting that not only overall O-glycan structures but also site-specific O-glycosylation can regulate EPHA2 activity.	Polysaccharides	0-8	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	36-43
32005975-7	2020	O-glycans on EPHA2 were modified by C1GALT1 and both S277A and T429A mutants, which are O-glycosites on EPHA2, dramatically enhanced phosphorylation of Y588, suggesting that not only overall O-glycan structures but also site-specific O-glycosylation can regulate EPHA2 activity.	Polysaccharides	0-8	EPH receptor A2	Homo sapiens	104-109
32005975-7	2020	O-glycans on EPHA2 were modified by C1GALT1 and both S277A and T429A mutants, which are O-glycosites on EPHA2, dramatically enhanced phosphorylation of Y588, suggesting that not only overall O-glycan structures but also site-specific O-glycosylation can regulate EPHA2 activity.	Polysaccharides	0-8	EPH receptor A2	Homo sapiens	104-109
32161592-5	2020	Although these findings indicate that MGL engagement by glycan ligands can modulate immune responses, the impact of MGL ligation on dendritic cells is still not completely understood.	Polysaccharides	56-62	C-type lectin domain containing 10A	Homo sapiens	38-41
31332909-5	2020	As a result of thermal treatment, the model protein, bovine serum albumin, was harder to degrade in terms of both overall biodegradability and hydrolysis rates when their macrostructures were changed from liquid to gel and to solid structures; the opposite was true for the model polysaccharide, amylopectin.	Polysaccharides	280-294	albumin	Homo sapiens	60-73
32111064-1	2020	Polysialic acid (polySia) is an unusual glycan that posttranslational modifies neural cell adhesion molecule (NCAM) proteins in mammalian cells.	Polysaccharides	40-46	neural cell adhesion molecule 1	Homo sapiens	79-108
32111064-1	2020	Polysialic acid (polySia) is an unusual glycan that posttranslational modifies neural cell adhesion molecule (NCAM) proteins in mammalian cells.	Polysaccharides	40-46	neural cell adhesion molecule 1	Homo sapiens	110-114
32184780-3	2020	Polymeric IgA1 with galactose-deficient hinge-region glycans is recognized as auto-antigen by glycan-specific antibodies, leading to formation of circulating immune complexes with nephritogenic consequences.	Polysaccharides	53-60	immunoglobulin heavy constant alpha 1	Homo sapiens	10-14
32175296-1	2020	UDP-glucose dehydrogenase (UGDH) encodes an oxidoreductase that converts two successive oxidations of UDP-glucose to produce UDP-glucuronic acid, a key component in the synthesis of several polysaccharides such as glycosaminoglycan and the disaccharide hyaluronic acid.	Polysaccharides	190-205	UDP-glucose 6-dehydrogenase	Homo sapiens	0-25
32175296-1	2020	UDP-glucose dehydrogenase (UGDH) encodes an oxidoreductase that converts two successive oxidations of UDP-glucose to produce UDP-glucuronic acid, a key component in the synthesis of several polysaccharides such as glycosaminoglycan and the disaccharide hyaluronic acid.	Polysaccharides	190-205	UDP-glucose 6-dehydrogenase	Homo sapiens	27-31
32175296-1	2020	UDP-glucose dehydrogenase (UGDH) encodes an oxidoreductase that converts two successive oxidations of UDP-glucose to produce UDP-glucuronic acid, a key component in the synthesis of several polysaccharides such as glycosaminoglycan and the disaccharide hyaluronic acid.	Polysaccharides	190-205	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	44-58
32161592-6	2020	Therefore, we employed RNA sequencing, GO term enrichment and pathway analysis on human monocyte-derived dendritic cells stimulated with two different MGL glycan ligands.	Polysaccharides	155-161	C-type lectin domain containing 10A	Homo sapiens	151-154
32128391-4	2020	We confirmed in vitro that knockdown of IKZF1 decreases the expression of fucosyltransferase FUT8, resulting in increased levels of fucosylated glycans, and suggest that RUNX1 and RUNX3, together with SMARCB1, regulate expression of glycosyltransferase MGAT3.	Polysaccharides	144-151	IKAROS family zinc finger 1	Homo sapiens	40-45
32296760-7	2020	These findings open new perspectives in GPCR biology and pharmacology since most GPCRs express N-glycan chains in their N-terminus, which might similarly be involved in the interaction with cell-surface glycan-specific lectins in the context of cell-to-cell mechanical signaling.	Polysaccharides	97-103	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	40-44
32084237-2	2020	To deliver the enzymatic "A" subunits of the toxin to the site of action in host cells, the receptor-binding "B" subunit PltB binds to the trisaccharide glycan receptor moieties terminated in N-acetylneuraminic acid (Neu5Ac) that is alpha2-3 or alpha2-6 linked to the underlying disaccharide, galactose (Gal) and N-acetylglucosamine (GlcNAc).	Polysaccharides	153-159	immunoglobulin kappa variable 2-24	Homo sapiens	233-241
32084237-2	2020	To deliver the enzymatic "A" subunits of the toxin to the site of action in host cells, the receptor-binding "B" subunit PltB binds to the trisaccharide glycan receptor moieties terminated in N-acetylneuraminic acid (Neu5Ac) that is alpha2-3 or alpha2-6 linked to the underlying disaccharide, galactose (Gal) and N-acetylglucosamine (GlcNAc).	Polysaccharides	153-159	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	245-253
32050432-0	2020	Clinically Relevant Insulin Degludec and its Interaction with Polysaccharides: A Biophysical Examination.	Polysaccharides	62-77	insulin	Homo sapiens	20-27
32075064-0	2020	Spin-Coated Polysaccharide-Based Multilayered Freestanding Films with Adhesive and Bioactive Moieties.	Polysaccharides	12-26	spindlin 1	Homo sapiens	0-4
32133009-5	2020	For example, variable domain glycans are abundantly found by anti-citrullinated protein antibodies (ACPA) in rheumatoid arthritis (RA) as well as by the B-cell receptors of follicular lymphoma (FL).	Polysaccharides	29-36	proteinase 3	Homo sapiens	100-104
31887381-4	2020	However, few researches have focused on the polysaccharide in RaF.	Polysaccharides	44-58	zinc fingers and homeoboxes 2	Homo sapiens	62-65
31887381-5	2020	In this study, a purified polysaccharide (Rap-1) was isolated with an average molecular weight of 1029.7 kDa.	Polysaccharides	26-40	RAP1A, member of RAS oncogene family	Homo sapiens	42-47
31589958-2	2020	Absence of Lon in E. coli results in sensitivity to DNA damaging agents and over-production of capsular polysaccharide due to accumulation of Lon substrates, SulA (cell division inhibitor induced upon DNA damage) and RcsA (activator of cps genes), respectively.	Polysaccharides	104-118	putative ATP-dependent Lon protease	Escherichia coli	11-14
31589958-2	2020	Absence of Lon in E. coli results in sensitivity to DNA damaging agents and over-production of capsular polysaccharide due to accumulation of Lon substrates, SulA (cell division inhibitor induced upon DNA damage) and RcsA (activator of cps genes), respectively.	Polysaccharides	104-118	putative ATP-dependent Lon protease	Escherichia coli	142-145
32082178-7	2019	TGF-beta also upregulated several genes related to glycan metabolism and ion transport.	Polysaccharides	51-57	transforming growth factor alpha	Mus musculus	0-8
31930911-13	2020	Finally, our finding that hItln-1 avoids binding prevalent glycans with a terminal 1,2-diol (e.g., N-acetyl-neuraminic acid and l-glycero-alpha-d-manno-heptose) suggests the lectin has evolved to recognize distinct bacterial species.	Polysaccharides	59-66	intelectin 1	Homo sapiens	26-33
31907993-6	2020	Unusual glycan epitopes identified on CD11b/CD18 included high Mannose oligosaccharides recognized by the Galanthus Nivalis lectin and biantennary galactosylated N-glycans recognized by the Phaseolus Vulgaris erythroagglutinin lectin.	Polysaccharides	8-14	integrin subunit alpha M	Homo sapiens	38-43
31907993-7	2020	Importantly, we show that selective targeting of glycans on CD11b with such lectins results in altered intracellular signaling events that inhibit TEpM and differentially affect key PMN inflammatory functions including phagocytosis, superoxide release and apoptosis.	Polysaccharides	49-56	integrin subunit alpha M	Homo sapiens	60-65
31907993-8	2020	Taken together, these data demonstrate that discrete glycan motifs expressed on CD11b/CD18 such as biantennary galactose could represent novel targets for selective manipulation of CD11b function and reduction of PMN-associated tissue damage in chronic inflammatory diseases.	Polysaccharides	53-59	integrin subunit alpha M	Homo sapiens	80-85
31907993-8	2020	Taken together, these data demonstrate that discrete glycan motifs expressed on CD11b/CD18 such as biantennary galactose could represent novel targets for selective manipulation of CD11b function and reduction of PMN-associated tissue damage in chronic inflammatory diseases.	Polysaccharides	53-59	integrin subunit alpha M	Homo sapiens	181-186
31894851-0	2020	Astragalus polysaccharide attenuates metabolic memory-triggered ER stress and apoptosis via regulation of miR-204/SIRT1 axis in retinal pigment epithelial cells.	Polysaccharides	11-25	microRNA 204	Homo sapiens	106-113
31894851-0	2020	Astragalus polysaccharide attenuates metabolic memory-triggered ER stress and apoptosis via regulation of miR-204/SIRT1 axis in retinal pigment epithelial cells.	Polysaccharides	11-25	sirtuin 1	Homo sapiens	114-119
31882545-9	2020	Given that mucins and their O-glycans are known to interact with various microbes, our results suggest that loss of Galnt3 decreases glycosylation of Muc10, which alters the composition and stability of the oral microbiome.	Polysaccharides	28-37	polypeptide N-acetylgalactosaminyltransferase 3	Homo sapiens	116-122
32149536-5	2020	In this report, various assay platforms such as glycan profiling, site-specific glycopeptide profiling, and intact protein profiling are introduced for the detection of abnormal glycosylation of serum haptoglobin.Expert opinion: Although aberrant glycosylation of serum haptoglobin is associated with gastric cancer patients and might be a promising marker of GC screening, the development of a diagnosis platform to increase specificity and sensitivity for clinical use is still an analytical challenge.	Polysaccharides	48-54	haptoglobin	Homo sapiens	201-212
31672634-1	2020	This work was conducted to evaluate the compatibility between physicochemical, antioxidant and morphological properties of polysaccharide (FRP) extracted from red marine alga Falkenbergia rufolanosa reinforced by poly (vinyl alcohol) (PVA) composed films at different ratios of FRP/PVA: F1 (70:30), F2 (50:50), F3 (30:70) and PVA (100% PVA) and the potential wound healing effects.	Polysaccharides	123-137	secreted frizzled-related protein 4	Rattus norvegicus	139-142
31672634-1	2020	This work was conducted to evaluate the compatibility between physicochemical, antioxidant and morphological properties of polysaccharide (FRP) extracted from red marine alga Falkenbergia rufolanosa reinforced by poly (vinyl alcohol) (PVA) composed films at different ratios of FRP/PVA: F1 (70:30), F2 (50:50), F3 (30:70) and PVA (100% PVA) and the potential wound healing effects.	Polysaccharides	123-137	secreted frizzled-related protein 4	Rattus norvegicus	278-281
31945398-8	2020	RESULTS: Compared to the parent S. mutans, the rnc-deletion technique yielded significantly less biofilm biomass, polysaccharides, metabolic activity, CFU, and lactic acid for biofilms grown on control composite (p <  0.05).	Polysaccharides	114-129	ribonuclease III	Streptococcus mutans UA159	47-50
31888963-8	2020	The CD16a N45-glycans contain markedly less processing than other sites with >75% hybrid and oligomannose forms.	Polysaccharides	14-21	Fc gamma receptor IIIa	Homo sapiens	4-9
31819007-5	2020	Using immunoblotting, flow cytometry, and LC-MS-based glycolipid and glycan profiling, we found that CRISPR/Cas9-mediated GALE deletion in human cells triggers major imbalances in NSs and dramatic changes in glycolipids and glycoproteins, including a subset of integrins and the cell-surface death receptor FS-7-associated surface antigen.	Polysaccharides	69-75	UDP-galactose-4-epimerase	Homo sapiens	122-126
31095840-1	2020	CD22 (Siglec-2) is a B-cell surface inhibitory protein capable of selectively recognising sialylated glycans, thus dampening autoimmune responses against self-antigens.	Polysaccharides	101-108	CD22 molecule	Homo sapiens	0-4
31776523-4	2020	Specifically, LAPONITE  (LAP) nanoplatelets are able to accelerate the gelation process through hydrogen bonds with polysaccharide matrices, endowing hydrogels with superior mechanical and rheological behaviors, along with better injectability and self-healing ability.	Polysaccharides	116-130	LAP	Homo sapiens	14-17
31949166-4	2020	Fukutin and fukutin-related protein (FKRP), whose mutated genes underlie dystroglycanopathy, sequentially transfer RboP from cytidine diphosphate-ribitol (CDP-Rbo) to form a tandem RboP unit in the core M3 glycan.	Polysaccharides	79-85	fukutin	Homo sapiens	0-7
31949166-4	2020	Fukutin and fukutin-related protein (FKRP), whose mutated genes underlie dystroglycanopathy, sequentially transfer RboP from cytidine diphosphate-ribitol (CDP-Rbo) to form a tandem RboP unit in the core M3 glycan.	Polysaccharides	79-85	fukutin related protein	Homo sapiens	12-35
31949166-4	2020	Fukutin and fukutin-related protein (FKRP), whose mutated genes underlie dystroglycanopathy, sequentially transfer RboP from cytidine diphosphate-ribitol (CDP-Rbo) to form a tandem RboP unit in the core M3 glycan.	Polysaccharides	79-85	fukutin related protein	Homo sapiens	37-41
31868189-1	2020	A novel enzyme-responsive supramolecular polysaccharide assembly composed of disulfide linked adamantane-naphthalimide fluorescent camptothecin prodrug (AdaCPT) and beta-CD modified hyaluronic acid (HACD) was constructed, possessing low cellular cytotoxicity and exhibiting targeted cellular imaging and controlled drug release at specific sites while providing a concurrent means for the real-time tracking of drug delivery.	Polysaccharides	41-55	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	165-172
31859482-7	2020	Furthermore, our approach enabled the analysis of deglycosylated peptides and glycans from enriched IGPs following PNGase F digest.	Polysaccharides	78-85	N-glycanase 1	Homo sapiens	115-121
31095840-1	2020	CD22 (Siglec-2) is a B-cell surface inhibitory protein capable of selectively recognising sialylated glycans, thus dampening autoimmune responses against self-antigens.	Polysaccharides	101-108	CD22 molecule	Homo sapiens	6-14
31998300-1	2019	Because of a loss-of-function mutation in the GGTA1 gene, humans are unable to synthetize alpha1,3-Galactose (Gal) decorated glycans and develop high levels of circulating anti-alpha1,3-Galactose antibodies (anti-Gal Abs).	Polysaccharides	125-132	glycoprotein alpha-galactosyltransferase 1 (inactive)	Homo sapiens	46-51
31952203-0	2020	Complex Polysaccharide-Based Nanocomposites for Oral Insulin Delivery.	Polysaccharides	8-22	insulin	Homo sapiens	53-60
32568201-7	2020	For all individuals, a single O-linked glycan was observed in plasma, while two glycans (of the same type) per apoE were observed in CSF.	Polysaccharides	80-87	apolipoprotein E	Homo sapiens	111-115
32152943-1	2020	CLEC5A is a spleen tyrosine kinase (Syk)-coupled C-type lectin that is highly expressed by monocytes, macrophages, neutrophils, and dendritic cells and interacts with virions directly, via terminal fucose and mannose moieties of viral glycans.	Polysaccharides	235-242	C-type lectin domain containing 5A	Homo sapiens	0-6
32152943-1	2020	CLEC5A is a spleen tyrosine kinase (Syk)-coupled C-type lectin that is highly expressed by monocytes, macrophages, neutrophils, and dendritic cells and interacts with virions directly, via terminal fucose and mannose moieties of viral glycans.	Polysaccharides	235-242	spleen associated tyrosine kinase	Homo sapiens	36-39
31369681-3	2020	The orientation between the carbohydrate-recognition domain of Clec4f and its neck region differs from other C-type lectins, resulting in an observed distance of 45 A between the glycan-binding sites within the Clec4f trimer.	Polysaccharides	179-185	C-type lectin domain family 4, member f	Mus musculus	63-69
31369681-3	2020	The orientation between the carbohydrate-recognition domain of Clec4f and its neck region differs from other C-type lectins, resulting in an observed distance of 45 A between the glycan-binding sites within the Clec4f trimer.	Polysaccharides	179-185	C-type lectin domain family 4, member f	Mus musculus	211-217
31699441-2	2020	However, Rev.1 may cause abortions in small ruminants that have been vaccinated during the last trimester of gestation, it is pathogenic to humans, and it induces antibodies directed at the O-polysaccharide (O-PS) of the smooth lipopolysaccharide, thus making it difficult to distinguish between vaccinated and infected animals.	Polysaccharides	190-206	REV1 DNA directed polymerase	Homo sapiens	9-14
31699441-2	2020	However, Rev.1 may cause abortions in small ruminants that have been vaccinated during the last trimester of gestation, it is pathogenic to humans, and it induces antibodies directed at the O-polysaccharide (O-PS) of the smooth lipopolysaccharide, thus making it difficult to distinguish between vaccinated and infected animals.	Polysaccharides	208-212	REV1 DNA directed polymerase	Homo sapiens	9-14
32089236-4	2020	Most of the antitumor polysaccharides belong to conserved beta-glucans, with a linear beta-(1 3)-glucan backbone and attached beta-(1 6) branch.	Polysaccharides	22-37	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	86-95
32089236-4	2020	Most of the antitumor polysaccharides belong to conserved beta-glucans, with a linear beta-(1 3)-glucan backbone and attached beta-(1 6) branch.	Polysaccharides	22-37	immunoglobulin kappa variable 3-31 (pseudogene)	Homo sapiens	126-135
31604106-10	2019	Ugp2 is the major limiting enzyme of the O-glycan precursor synthesis in recombinant hCG protein production.	Polysaccharides	41-49	glycoprotein hormones, alpha polypeptide	Homo sapiens	85-88
33079615-8	2020	PK analyses in humanized FcRn transgenic mouse (homozygous Tg32 and Tg276) and non-human primate (NHP) models showed that FcRn-binding mutations improved the plasma half-lives of the engineered mAbs and multispecific antibodies, while glycan engineering to eliminate effector function did not affect the PK compared with wild-type controls.	Polysaccharides	235-241	Fc gamma receptor and transporter	Homo sapiens	122-126
33218286-5	2020	As expected for monotherapy, viral loads rebounded after about a week and different viral escape pathways were observed, involving the deletion of glycans in the envelope glycoprotein at positions 130 or 160.	Polysaccharides	147-154	melanoma antigen	Mus musculus	162-183
32306330-3	2020	Although Fbs proteins recognize innermost Man3GlcNAc2 structure that is commonly found in most N-glycan structures, they preferentially bind high-mannose-type glycans.	Polysaccharides	159-166	F-box protein 8	Homo sapiens	9-12
32306336-3	2020	In this chapter, we will describe the preparation of recombinant soluble malectin and its tetramer, which might be developed as useful tools for detection of Glcalpha1-3Glc containing glycans on the cell surface.	Polysaccharides	184-191	malectin S homeolog	Xenopus laevis	73-81
32725167-3	2019	Purified MHC-I/TAPBPR complexes can be prepared for multiple human allotypes, and exhibit complex glycan modifications at the conserved Asn 86 residue.	Polysaccharides	98-104	TAP binding protein like	Homo sapiens	15-21
31776528-1	2019	Gum polysaccharides are derived from renewable sources.	Polysaccharides	4-19	OTU deubiquitinase with linear linkage specificity	Homo sapiens	0-3
31604106-4	2019	The effects of O-glycosylation on recombinant hCG protein expression were assessed by adding O-glycan precursors and overexpressing and knocking down key regulatory genes of O-glycan precursor synthesis and O-glycan sugar chain synthesis or hydrolases.	Polysaccharides	93-101	glycoprotein hormones, alpha polypeptide	Homo sapiens	46-49
31604106-4	2019	The effects of O-glycosylation on recombinant hCG protein expression were assessed by adding O-glycan precursors and overexpressing and knocking down key regulatory genes of O-glycan precursor synthesis and O-glycan sugar chain synthesis or hydrolases.	Polysaccharides	174-182	glycoprotein hormones, alpha polypeptide	Homo sapiens	46-49
31604106-4	2019	The effects of O-glycosylation on recombinant hCG protein expression were assessed by adding O-glycan precursors and overexpressing and knocking down key regulatory genes of O-glycan precursor synthesis and O-glycan sugar chain synthesis or hydrolases.	Polysaccharides	174-182	glycoprotein hormones, alpha polypeptide	Homo sapiens	46-49
31461539-1	2020	L-Ara is a major monosaccharide in plant polysaccharides and glycoproteins, and functions in plant growth and development.	Polysaccharides	41-56	Rab GTPase-like A5A protein	Arabidopsis thaliana	2-5
31378960-0	2020	Impaired polysaccharide responsiveness without agammaglobulinaemia in three patients with hypomorphic mutations in Bruton Tyrosine Kinase-No detection by newborn screening for primary immunodeficiencies.	Polysaccharides	9-23	Bruton tyrosine kinase	Homo sapiens	115-137
31378960-3	2020	We aimed to evaluate clinical findings, BTK function and KREC copy numbers in three patients with BTK mutations presenting with impaired polysaccharide responsiveness without agammaglobulinaemia.	Polysaccharides	137-151	Bruton tyrosine kinase	Homo sapiens	98-101
31604106-11	2019	Furthermore, the effects and mechanisms of the key genes of O-glycan sugar chain synthesis and hydrolases such as polypeptide N-acetylgalactosaminyltransferase1 (Galnt1), Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (C1galt1), O-linked N-acetylglucosamine transferase (Ogt) and Hexosaminidase (Hex), were evaluated.	Polysaccharides	60-68	polypeptide N-acetylgalactosaminyltransferase 1	Cricetulus griseus	162-168
31604106-6	2019	Glutamine-fructose-6-phosphate transaminase 2 (Gfat2) and Uridine diphosphate-glucose pyrophosphorylase 2 (Ugp2), key regulatory genes of O-glycan precursor synthesis, were overexpressed.	Polysaccharides	138-146	LOW QUALITY PROTEIN: glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	Cricetulus griseus	0-45
31604106-6	2019	Glutamine-fructose-6-phosphate transaminase 2 (Gfat2) and Uridine diphosphate-glucose pyrophosphorylase 2 (Ugp2), key regulatory genes of O-glycan precursor synthesis, were overexpressed.	Polysaccharides	138-146	LOW QUALITY PROTEIN: glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2	Cricetulus griseus	47-52
31604106-11	2019	Furthermore, the effects and mechanisms of the key genes of O-glycan sugar chain synthesis and hydrolases such as polypeptide N-acetylgalactosaminyltransferase1 (Galnt1), Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (C1galt1), O-linked N-acetylglucosamine transferase (Ogt) and Hexosaminidase (Hex), were evaluated.	Polysaccharides	60-68	LOW QUALITY PROTEIN: glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Cricetulus griseus	253-260
31604106-6	2019	Glutamine-fructose-6-phosphate transaminase 2 (Gfat2) and Uridine diphosphate-glucose pyrophosphorylase 2 (Ugp2), key regulatory genes of O-glycan precursor synthesis, were overexpressed.	Polysaccharides	138-146	UTP--glucose-1-phosphate uridylyltransferase	Cricetulus griseus	58-105
31604106-6	2019	Glutamine-fructose-6-phosphate transaminase 2 (Gfat2) and Uridine diphosphate-glucose pyrophosphorylase 2 (Ugp2), key regulatory genes of O-glycan precursor synthesis, were overexpressed.	Polysaccharides	138-146	UTP--glucose-1-phosphate uridylyltransferase	Cricetulus griseus	107-111
31604106-11	2019	Furthermore, the effects and mechanisms of the key genes of O-glycan sugar chain synthesis and hydrolases such as polypeptide N-acetylgalactosaminyltransferase1 (Galnt1), Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (C1galt1), O-linked N-acetylglucosamine transferase (Ogt) and Hexosaminidase (Hex), were evaluated.	Polysaccharides	60-68	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	Cricetulus griseus	263-303
31604106-10	2019	Ugp2 is the major limiting enzyme of the O-glycan precursor synthesis in recombinant hCG protein production.	Polysaccharides	41-49	UTP--glucose-1-phosphate uridylyltransferase	Cricetulus griseus	0-4
31604106-11	2019	Furthermore, the effects and mechanisms of the key genes of O-glycan sugar chain synthesis and hydrolases such as polypeptide N-acetylgalactosaminyltransferase1 (Galnt1), Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (C1galt1), O-linked N-acetylglucosamine transferase (Ogt) and Hexosaminidase (Hex), were evaluated.	Polysaccharides	60-68	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	Cricetulus griseus	305-308
31604106-13	2019	Galnt1 is the major limiting enzyme of O-glycan sugar chain synthesis.	Polysaccharides	39-47	polypeptide N-acetylgalactosaminyltransferase 1	Cricetulus griseus	0-6
31529034-5	2019	While it is known that covalent labeling of a GBP may influence its binding properties, these effects have not been well studied and are usually overlooked when analyzing glycan array data.	Polysaccharides	171-177	galectin 1	Homo sapiens	46-49
31841553-3	2019	During natural HIV-1 infection, neutralizing antibodies are made against glycans on HIV-1 envelope glycoprotein (Env).	Polysaccharides	73-80	endogenous retrovirus group K member 20	Homo sapiens	90-111
31841553-3	2019	During natural HIV-1 infection, neutralizing antibodies are made against glycans on HIV-1 envelope glycoprotein (Env).	Polysaccharides	73-80	endogenous retrovirus group K member 20	Homo sapiens	113-116
31841553-7	2019	Here, we show that DH501 Env glycan reactivity is mediated by both germline-encoded residues that contact glycans, and somatic mutations that increase antibody paratope flexibility.	Polysaccharides	29-35	endogenous retrovirus group K member 20	Homo sapiens	25-28
31841553-7	2019	Here, we show that DH501 Env glycan reactivity is mediated by both germline-encoded residues that contact glycans, and somatic mutations that increase antibody paratope flexibility.	Polysaccharides	106-113	endogenous retrovirus group K member 20	Homo sapiens	25-28
31841553-11	2019	The requirement for the presence of most somatic mutations across the heavy chain variable region provides one explanation for the difficulty in inducing anti-Env glycan antibodies with HIV-1 Env vaccination.	Polysaccharides	163-169	endogenous retrovirus group K member 20	Homo sapiens	159-162
31529034-3	2019	Currently, the glycan specificities of GBPs are most often inferred from binding data generated using glycan arrays, wherein the GBP is incubated with oligosaccharides immobilized on a glass surface.	Polysaccharides	15-21	galectin 1	Homo sapiens	39-42
31529034-3	2019	Currently, the glycan specificities of GBPs are most often inferred from binding data generated using glycan arrays, wherein the GBP is incubated with oligosaccharides immobilized on a glass surface.	Polysaccharides	102-108	galectin 1	Homo sapiens	39-42
30842360-6	2019	In addition to Mnn4, Mnn6 is known to be also required for the transfer of mannosyl phosphate to the glycans.	Polysaccharides	101-108	putative mannosyltransferase	Saccharomyces cerevisiae S288C	21-25
31529034-9	2019	These findings demonstrate that GBP labeling may affect both the absolute and relative affinities and, thereby, obscure the true glycan binding properties.	Polysaccharides	129-135	galectin 1	Homo sapiens	32-35
31564450-5	2019	Antibody binding assay showed that removal of N276/N463 glycans together with the deletion of V1/V2 region enhanced the binding of gp140s to CD4-binding site-targeting bNAbs VRC01 and 3BNC117, and CD4-induced epitopes-targeting non-NAbs A32, 17b and F425 A1g8, whereas further deletion of V3 crown in the gp140 mutants demonstrated slightly compromised binding capability to these Abs.	Polysaccharides	56-63	CD4 molecule	Homo sapiens	141-144
31817246-5	2019	We demonstrated that mannose-containing glycans increased on glycoproteins in aged mouse brains and identified synapsin-1 as one major carrier of paucimannose in aged brains.	Polysaccharides	40-47	synapsin I	Mus musculus	111-121
31564450-5	2019	Antibody binding assay showed that removal of N276/N463 glycans together with the deletion of V1/V2 region enhanced the binding of gp140s to CD4-binding site-targeting bNAbs VRC01 and 3BNC117, and CD4-induced epitopes-targeting non-NAbs A32, 17b and F425 A1g8, whereas further deletion of V3 crown in the gp140 mutants demonstrated slightly compromised binding capability to these Abs.	Polysaccharides	56-63	CD4 molecule	Homo sapiens	197-200
31564450-7	2019	Taken together, our results indicate that removal of glycans at N276/N463 and deletion of the V1/V2 region can expose the CD4-binding site and CD4-induced epitopes, but such exposure alone appears incapable of enhancing the induction of bNAbs in mice, informing that additional modification or/and immunization strategies are needed.	Polysaccharides	53-60	CD4 antigen	Mus musculus	122-125
31564450-7	2019	Taken together, our results indicate that removal of glycans at N276/N463 and deletion of the V1/V2 region can expose the CD4-binding site and CD4-induced epitopes, but such exposure alone appears incapable of enhancing the induction of bNAbs in mice, informing that additional modification or/and immunization strategies are needed.	Polysaccharides	53-60	CD4 antigen	Mus musculus	143-146
31521276-0	2019	Polysaccharide enhanced NK cell cytotoxicity against pancreatic cancer via TLR4/MAPKs/NF-kappaB pathway in vitro/vivo.	Polysaccharides	0-14	toll-like receptor 4	Mus musculus	75-79
31471298-5	2019	Here, we determined the presence of ACPA-IgG V-domain glycans in paired samples of pre-symptomatic individuals and RA patients.	Polysaccharides	54-61	proteinase 3	Homo sapiens	36-40
31471298-7	2019	RESULTS: V-domain glycans on ACPA-IgG were already present up to 15 years before disease in pre-symptomatic individuals and their abundance increased closer to symptom onset.	Polysaccharides	18-25	proteinase 3	Homo sapiens	29-33
31471298-8	2019	Noteworthy, human leucocyte antigen class II shared epitope (HLA-SE) alleles associated with the presence of V-domain glycans on ACPA-IgG.	Polysaccharides	118-125	proteinase 3	Homo sapiens	129-133
31471298-9	2019	CONCLUSION: Our observations indicate that somatic hypermutation of ACPA, which results in the incorporation of N-linked glycosylation sites and consequently V-domain glycans, occurs already years before symptom onset in individuals that will develop RA later in life.	Polysaccharides	167-174	proteinase 3	Homo sapiens	68-72
31159593-0	2019	Astragalus polysaccharide alleviates H2O2-triggered oxidative injury in human umbilical vein endothelial cells via promoting KLF2.	Polysaccharides	11-25	Kruppel like factor 2	Homo sapiens	125-129
31870255-6	2019	GPI-modified proteins non-covalently attached to the high-molecular-weight polysaccharides were found in the cell walls of both the parent strain and yeast devoid of glucanosyltransglycosylase Bgl2, which indicates that the pathway of their incorporation into the cell wall is independent on this enzyme.	Polysaccharides	75-90	glucan 1,3-beta-glucosidase	Saccharomyces cerevisiae S288C	193-197
30765116-1	2019	Levan is a polysaccharide composed of fructose units with beta-2,6-glycoside bonds.	Polysaccharides	11-25	ATPase H+ transporting V0 subunit a2	Homo sapiens	58-64
31521276-0	2019	Polysaccharide enhanced NK cell cytotoxicity against pancreatic cancer via TLR4/MAPKs/NF-kappaB pathway in vitro/vivo.	Polysaccharides	0-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-95
31595388-10	2019	Given that the integrin beta1 subunit is the main carrier of the STn epitope, it is likely that changes in glycan structure impaired the adhesive capacity of beta1 integrin in the bone environment, leading to attenuation of tumor cell engraftment.	Polysaccharides	107-113	integrin subunit beta 1	Homo sapiens	158-172
31476363-2	2019	Sialic acid (Sia), and in particular, 5-N-acetylneuraminic acid (Neu5Ac), is chemically bound to galactose and the underlying glycan via alpha2-3 or alpha2-6 glycosidic linkage (i.e., Siaalpha2-3Galactose or Siaalpha2-6Galactose), conferring two different cell surface structures that affects cell to cell communication and interactions with foreign agents including microparasites and toxins.	Polysaccharides	126-132	immunoglobulin binding protein 1	Homo sapiens	149-157
31411777-5	2019	A suppressor screen of mutagenized pmr5 seed selecting for increased powdery mildew susceptibility identified two previously characterized genes affecting acetylation of plant cell wall polysaccharides, RWA2 and TBR.	Polysaccharides	186-201	Pmr5/Cas1p GDSL/SGNH-like acyl-esterase family protein (DUF828)	Arabidopsis thaliana	35-39
31678713-2	2019	Glycan-engineered vaccines facilitate both DC targeting and increased uptake by DCs for processing and presentation to CD4+ and CD8+ T cells to induce tumor-specific T-cell responses.	Polysaccharides	0-6	CD4 molecule	Homo sapiens	119-122
31678713-2	2019	Glycan-engineered vaccines facilitate both DC targeting and increased uptake by DCs for processing and presentation to CD4+ and CD8+ T cells to induce tumor-specific T-cell responses.	Polysaccharides	0-6	CD8a molecule	Homo sapiens	128-131
31773366-0	2019	Glycan structures and their recognition roles in the human blood group ABH/Ii, Lea, b, x, y and Sialyl Lea,x active cyst glycoproteins.	Polysaccharides	0-6	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	71-74
31491513-0	2019	MDG-1, an Ophiopogon polysaccharide, restrains process of non-alcoholic fatty liver disease via modulating the gut-liver axis.	Polysaccharides	21-35	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	0-5
31382820-3	2019	The soluble non-starch polysaccharide fraction (QPS1) was subsequently purified by DEAE-52 cellulose and Sephadex G-50 gel chromatography, using QPS as raw materials.	Polysaccharides	23-37	succinate dehydrogenase complex, subunit C, integral membrane protein	Mus musculus	48-52
31732167-3	2019	The exceptions to the contiguous glycan shield include the conserved receptor CD4 binding site (CD4bs) and glycoprotein (gp)41 elements proximal to the furin cleavage site.	Polysaccharides	33-39	T-cell surface glycoprotein CD4	Oryctolagus cuniculus	78-81
31504498-0	2019	Bioinformatics analysis of diversity in bacterial glycan chain-termination chemistry and organization of carbohydrate binding modules linked to ABC transporters.	Polysaccharides	50-56	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	144-147
31504498-3	2019	In one of the major processes, found in both Gram-positive and Gram-negative bacteria, the glycan is polymerized in the cytoplasm on a polyprenol lipid carrier and exported from the cytoplasm by an ATP-binding cassette (ABC) transporter.	Polysaccharides	91-97	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	220-223
31504498-4	2019	The ABC transporter actively participates in determining the chain length of the glycan substrate, which impacts functional properties of the glycoconjugate products.	Polysaccharides	81-87	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	4-7
31504498-6	2019	The hallmarks of prototypical capped-glycan systems are a chain terminating enzyme possessing a coiled-coil molecular ruler and an ABC transporter possessing a carbohydrate-binding module (CBM) which recognizes the glycan cap.	Polysaccharides	37-43	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	131-134
31504498-6	2019	The hallmarks of prototypical capped-glycan systems are a chain terminating enzyme possessing a coiled-coil molecular ruler and an ABC transporter possessing a carbohydrate-binding module (CBM) which recognizes the glycan cap.	Polysaccharides	215-221	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	131-134
31732167-3	2019	The exceptions to the contiguous glycan shield include the conserved receptor CD4 binding site (CD4bs) and glycoprotein (gp)41 elements proximal to the furin cleavage site.	Polysaccharides	33-39	furin	Oryctolagus cuniculus	152-157
31732167-3	2019	The exceptions to the contiguous glycan shield include the conserved receptor CD4 binding site (CD4bs) and glycoprotein (gp)41 elements proximal to the furin cleavage site.	Polysaccharides	33-39	T-cell surface glycoprotein CD4	Oryctolagus cuniculus	96-99
31743334-1	2019	BACKGROUND: Antibodies targeting O-specific polysaccharide (OSP) of Vibrio cholerae may protect against cholera; however, little is known about this immune response in infected immunologically naive humans.	Polysaccharides	44-58	claudin 11	Homo sapiens	60-63
31558605-7	2019	Pretreatment with a beta-d-1,4-xylanase did enable CE1 domain-mediated FA release from arabinoxylan in the absence of CBM48, indicating that CBM48 is essential for the CE1 activity on the polysaccharide.	Polysaccharides	188-202	carboxylesterase 1	Homo sapiens	51-54
31558605-7	2019	Pretreatment with a beta-d-1,4-xylanase did enable CE1 domain-mediated FA release from arabinoxylan in the absence of CBM48, indicating that CBM48 is essential for the CE1 activity on the polysaccharide.	Polysaccharides	188-202	carboxylesterase 1	Homo sapiens	168-171
31727010-1	2019	BACKGROUND: PMM2-CDG, is the most common N-linked glycosylation disorder and subtype among all CDG syndromes, which are a series of genetic disorders involving the synthesis and attachment of glycoproteins and glycolipid glycans.	Polysaccharides	221-228	phosphomannomutase 2	Homo sapiens	12-16
31698460-0	2019	Increased Mac-2 binding protein glycan isomer in patients at risk for late nonrelapse mortality after HSCT.	Polysaccharides	32-38	galectin 3 binding protein	Homo sapiens	10-31
31244409-0	2019	Inhibitory effects of a sulfated polysaccharide isolated from edible red alga Bangia fusco-purpurea on alpha-amylase and alpha-glucosidase.	Polysaccharides	33-47	sucrase-isomaltase	Homo sapiens	121-138
31577134-1	2019	Sialic acids form the terminal sugars in glycan chains on glycoproteins via alpha2,3, alpha2,6, or alpha2,8 linkages, and structural isomers of sialyl linkages play various functional roles in cell recognition and other physiological processes.	Polysaccharides	41-47	immunoglobulin kappa variable 2-24	Homo sapiens	76-84
31577134-1	2019	Sialic acids form the terminal sugars in glycan chains on glycoproteins via alpha2,3, alpha2,6, or alpha2,8 linkages, and structural isomers of sialyl linkages play various functional roles in cell recognition and other physiological processes.	Polysaccharides	41-47	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	86-94
31577134-1	2019	Sialic acids form the terminal sugars in glycan chains on glycoproteins via alpha2,3, alpha2,6, or alpha2,8 linkages, and structural isomers of sialyl linkages play various functional roles in cell recognition and other physiological processes.	Polysaccharides	41-47	immunoglobulin kappa variable 2-19 (pseudogene)	Homo sapiens	99-107
31494294-0	2019	A pH-sensitive nanotherapeutic system based on a marine sulfated polysaccharide for the treatment of metastatic breast cancer through combining chemotherapy and COX-2 inhibition.	Polysaccharides	65-79	prostaglandin-endoperoxide synthase 2	Mus musculus	161-166
31244409-1	2019	In this study, a sulfated polysaccharide (BFP) was isolated from the edible red alga Bangia fusco-purpurea.	Polysaccharides	26-40	ring finger protein 112	Homo sapiens	42-45
31244409-2	2019	Gel-filtration and thin layer chromatographically analyses suggested that BFP was a homogenous polysaccharide.	Polysaccharides	95-109	ring finger protein 112	Homo sapiens	74-77
31499012-9	2019	Finally, coimmunoprecipitation experiments showed a glycan-dependent interaction between Syn-2-bearing virions and Gal-1.	Polysaccharides	52-58	synapsin II	Homo sapiens	89-94
31426957-2	2019	A homogeneous polysaccharide, LRP3-S1 with a relative molecular weight of 114.8 kDa was purified by anion-exchange chromatography on DEAE Sepharose Fast Flow and Sephacryl S-300 HR column.	Polysaccharides	14-28	LDL receptor related protein 3	Homo sapiens	30-34
31426994-1	2019	A novel polysaccharide designated SLP-4 with the Mw of 19681 Da was purified from the petal of Saussurea laniceps.	Polysaccharides	8-22	sphingosine-1-phosphate receptor 4	Homo sapiens	34-39
31427001-3	2019	Cell counting kit- 8 (CCK-8), colony formation, scratch, and Transwell assays showed that Huaier polysaccharide (HP-1) reduced tumor progression.	Polysaccharides	97-111	haptoglobin	Mus musculus	113-117
31499012-9	2019	Finally, coimmunoprecipitation experiments showed a glycan-dependent interaction between Syn-2-bearing virions and Gal-1.	Polysaccharides	52-58	galectin 1	Homo sapiens	115-120
31400419-1	2019	In this study, three sulfated polysaccharides (S-RSP1-2, S-RSP1-4 and S-RSP1-8) from Rhodiola sachalinensis were produced by chlorosulfonic acid-pyridine method.	Polysaccharides	30-45	spermatogenesis associated, serine-rich 1	Mus musculus	57-65
31442508-0	2019	A polysaccharide isolated from the fruits of Physalis alkekengi L. induces RAW264.7 macrophages activation via TLR2 and TLR4-mediated MAPK and NF-kappaB signaling pathways.	Polysaccharides	2-16	toll-like receptor 2	Mus musculus	111-115
31442508-0	2019	A polysaccharide isolated from the fruits of Physalis alkekengi L. induces RAW264.7 macrophages activation via TLR2 and TLR4-mediated MAPK and NF-kappaB signaling pathways.	Polysaccharides	2-16	toll-like receptor 4	Mus musculus	120-124
31442509-0	2019	The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1alpha signaling axis mediated anti-oxidative in type 2 diabetes model mice.	Polysaccharides	33-47	sirtuin 1	Mus musculus	118-123
31450350-6	2019	The investigation on the sample structures and active oxygen species demonstrated that the highly active O2- species generated from HCO4- of NaHCO3-H2O2 acted preferentially on the GalA backbone in the HG region, while the RG-I region was maintained; and ultrasound enhanced the degradation efficiency via both chemical effects (increasing the transformation of free radicals) and mechanical effects (disaggregating polysaccharide clusters).	Polysaccharides	416-430	galactosidase alpha	Homo sapiens	181-185
31442509-0	2019	The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1alpha signaling axis mediated anti-oxidative in type 2 diabetes model mice.	Polysaccharides	33-47	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	124-134
31364656-5	2019	The association between these immobilized glycans and FITC-labeled concanavalin A (ConA) - a tetrameric GBP that binds to mannosides multivalently - was measured by fluorescence microscopy.	Polysaccharides	42-49	transmembrane protein 132A	Homo sapiens	104-107
31640540-4	2019	There are a number of popular web-based tools that are available for modeling glycans (e.g., GLYCAM-WEB (http:// https://dev.glycam.org/gp/ ) or Glycosciences.db ( http://www.glycosciences.de/ )).	Polysaccharides	78-85	ring finger protein 130	Homo sapiens	136-139
31655930-0	2019	Fluorometric visualization of mucin 1 glycans on cell surfaces based on rolling-mediated cascade amplification and CdTe quantum dots.	Polysaccharides	38-45	mucin 1, cell surface associated	Homo sapiens	30-37
31655930-1	2019	A rolling-mediated cascade (RMC) amplification strategy is described for improved visualization of profiling glycans of mucin 1 (MUC 1) on cell surfaces.	Polysaccharides	109-116	mucin 1, cell surface associated	Homo sapiens	120-127
31655930-1	2019	A rolling-mediated cascade (RMC) amplification strategy is described for improved visualization of profiling glycans of mucin 1 (MUC 1) on cell surfaces.	Polysaccharides	109-116	mucin 1, cell surface associated	Homo sapiens	129-134
31655930-8	2019	Graphical abstract Schematic for the DNA rolling-mediated cascade (RMC)-assisted metabolic labeling of cell surface glycans by using CdTe quantum dots as labels and an intramolecular amplified FRET strategy for imaging glycans on a specific glycosylated protein, MUC1.	Polysaccharides	116-123	mucin 1, cell surface associated	Rattus norvegicus	263-267
31313786-3	2019	Here, we report the synthesis of PEG-based glycopolymers with tunable glycan composition, which approximate the extended architecture of mucin glycoproteins, and tether them to the plasma membranes of red blood cells (RBC) to construct an artificial mucin brush-like glycocalyx.	Polysaccharides	70-76	LOC100508689	Homo sapiens	137-142
31313786-4	2019	We evaluated the association of two lectins, ConA and SNA, with their endogenous glycan ligands on the surface of the remodelled cells.	Polysaccharides	81-87	snail family transcriptional repressor 1	Homo sapiens	54-57
31628314-3	2019	We report that beta2AR activation requires two asparagine-branched glycan chains with terminally exposed N-acetyl-neuraminic acid (sialic acid, Neu5Ac) residues located at a specific distance in its N-terminus, while being independent of surrounding amino-acid residues.	Polysaccharides	67-73	adenosine A2a receptor	Homo sapiens	15-22
31498587-6	2019	The IgG antibodies recognized a wide range of MUC1 glycopeptides bearing diverse glycans.	Polysaccharides	81-88	mucin 1, transmembrane	Mus musculus	46-50
31628314-4	2019	Meningococcus triggers receptor signaling by exerting direct and hemodynamic-promoted traction forces on beta2AR glycans.	Polysaccharides	113-120	adenosine A2a receptor	Homo sapiens	105-112
31628314-6	2019	This previously unknown glycan-dependent mode of allosteric mechanical activation of a G protein-coupled receptor contributes to meningococcal species selectivity, since Neu5Ac is only abundant in humans due to the loss of CMAH, the enzyme converting Neu5Ac into N-glycolyl-neuraminic acid in other mammals.	Polysaccharides	24-30	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	223-227
31391273-7	2019	Particularly, for AAV serotype 9 and a rationally engineered AAV variant, we demonstrate that increased availability of galactosylated glycans on the surface of Crb3 KO cells, but not the universal AAV receptor (AAVR) leads to increased capsid attachment and enhanced transduction.	Polysaccharides	135-142	crumbs cell polarity complex component 3	Homo sapiens	161-165
31400416-3	2019	The results indicated that mannoproteins (MPs) and rhamnogalacturonans II (RG II) were the major polysaccharides to significantly alter the interaction of flavan-3-ols with bovine serum albumin (BSA).	Polysaccharides	97-112	albumin	Homo sapiens	180-193
31306703-1	2019	The purpose of this work is to stabilize zein nanoparticles with anionic polysaccharides-chondroitin sulfate (CS) to overcome the poor colloidal stability of zein nanoparticles.	Polysaccharides	73-88	citrate synthase	Homo sapiens	110-112
31391273-8	2019	We postulate that Crb3 could serve as a key molecular determinant that restricts the availability of AAV glycan attachment factors on the cell surface by maintaining apical-basal polarity and tight junction integrity.ImportanceAdeno-associated viruses (AAVs) have recently emerged at the forefront as gene therapy vectors; however, our understanding of host factors that influence AAV transduction in different cell types is still evolving.	Polysaccharides	105-111	crumbs cell polarity complex component 3	Homo sapiens	18-22
31488546-3	2019	Solid-phase binding competition assays, glycoprotein blotting experiments and glycan array analysis employing the lectin-like domains of cow and mouse CD23 demonstrate that they bind to mannose, N-acetylglucosamine, glucose, and fucose and to glycoproteins that bear these sugars in nonreducing terminal positions.	Polysaccharides	78-84	Fc receptor, IgE, low affinity II, alpha polypeptide	Mus musculus	151-155
31325506-0	2019	N-glycans of bovine submaxillary mucin contain core-fucosylated and sulfated glycans but not sialylated glycans.	Polysaccharides	2-9	mucin 1, cell surface associated	Bos taurus	33-38
31658587-6	2019	We hypothesize that salivary TFF3-FCGBP might play a role in the innate immune defense of the oral cavity and that TFF3 might also bind to microbial glycans.	Polysaccharides	149-156	trefoil factor 3	Homo sapiens	115-119
31511465-3	2019	The formation of protein-polysaccharide conjugates between SPI/SPH and dextran molecules was confirmed by SDS-PAGE; this finding was consistent with the degree of glycation and the browning index.	Polysaccharides	25-39	chromogranin A	Homo sapiens	59-62
31067000-4	2019	As ample evidence indicates that T cells drive the maturation of the ACPA response prior to arthritis onset, we undertook this study to investigate whether the presence of glycans in IgG ACPA V domains predicts the transition from predisease autoimmunity to overt RA.	Polysaccharides	172-179	proteinase 3	Homo sapiens	187-191
31067000-8	2019	RESULTS: In both data sets, FDR-derived IgG ACPA displayed markedly lower levels of V domain glycans (&lt;50%) compared to IgG ACPA from RA patients.	Polysaccharides	93-100	proteinase 3	Homo sapiens	44-48
31326513-1	2019	Chitosan (CS) and hyaluronic acid (HA) are two oppositely charged natural polysaccharides used widely for preparation of nanofibrous scaffolds for tissue engineering applications.	Polysaccharides	74-89	citrate synthase	Homo sapiens	10-12
31410472-6	2019	Dual epigenetic manipulation of the HNF1A and MGAT3 genes, involved in protein N-glycosylation, resulted in change of the glycan phenotype in BG1 cells.	Polysaccharides	122-128	HNF1 homeobox A	Homo sapiens	36-41
31410472-6	2019	Dual epigenetic manipulation of the HNF1A and MGAT3 genes, involved in protein N-glycosylation, resulted in change of the glycan phenotype in BG1 cells.	Polysaccharides	122-128	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	46-51
31121216-5	2019	Sialylation of cell surface glycans was reduced by KO of GNE (UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase), NANS (sialic acid synthase) and CMAS (N-acylneuraminate cytidylyltransferase) genes, but was largely unaffected in NANP (N-acylneuraminate-9-phosphatase) KO, as studied by MAA and PNA lectin binding.	Polysaccharides	28-35	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	57-60
31121216-5	2019	Sialylation of cell surface glycans was reduced by KO of GNE (UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase), NANS (sialic acid synthase) and CMAS (N-acylneuraminate cytidylyltransferase) genes, but was largely unaffected in NANP (N-acylneuraminate-9-phosphatase) KO, as studied by MAA and PNA lectin binding.	Polysaccharides	28-35	N-acetylneuraminate synthase	Homo sapiens	127-131
31121216-5	2019	Sialylation of cell surface glycans was reduced by KO of GNE (UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase), NANS (sialic acid synthase) and CMAS (N-acylneuraminate cytidylyltransferase) genes, but was largely unaffected in NANP (N-acylneuraminate-9-phosphatase) KO, as studied by MAA and PNA lectin binding.	Polysaccharides	28-35	N-acetylneuraminate synthase	Homo sapiens	133-153
31121216-5	2019	Sialylation of cell surface glycans was reduced by KO of GNE (UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase), NANS (sialic acid synthase) and CMAS (N-acylneuraminate cytidylyltransferase) genes, but was largely unaffected in NANP (N-acylneuraminate-9-phosphatase) KO, as studied by MAA and PNA lectin binding.	Polysaccharides	28-35	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	159-163
31121216-5	2019	Sialylation of cell surface glycans was reduced by KO of GNE (UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase), NANS (sialic acid synthase) and CMAS (N-acylneuraminate cytidylyltransferase) genes, but was largely unaffected in NANP (N-acylneuraminate-9-phosphatase) KO, as studied by MAA and PNA lectin binding.	Polysaccharides	28-35	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	165-203
31121216-5	2019	Sialylation of cell surface glycans was reduced by KO of GNE (UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase), NANS (sialic acid synthase) and CMAS (N-acylneuraminate cytidylyltransferase) genes, but was largely unaffected in NANP (N-acylneuraminate-9-phosphatase) KO, as studied by MAA and PNA lectin binding.	Polysaccharides	28-35	N-acetylneuraminic acid phosphatase	Homo sapiens	242-246
31121216-5	2019	Sialylation of cell surface glycans was reduced by KO of GNE (UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase), NANS (sialic acid synthase) and CMAS (N-acylneuraminate cytidylyltransferase) genes, but was largely unaffected in NANP (N-acylneuraminate-9-phosphatase) KO, as studied by MAA and PNA lectin binding.	Polysaccharides	28-35	N-acetylneuraminic acid phosphatase	Homo sapiens	248-279
31302422-0	2019	Astragalus polysaccharide ameliorates lipopolysaccharide-induced cell injury in ATDC5 cells via miR-92a/KLF4 mediation.	Polysaccharides	11-25	Kruppel-like factor 4 (gut)	Mus musculus	104-108
31429425-1	2019	Sulfated polysaccharides have received much attention in recent years due to their special biological activities, especially the regulation of the biological activity of growth factors such as the representative inductive growth factor recombinant human bone morphogenetic protein-2 (rhBMP-2).	Polysaccharides	9-24	bone morphogenetic protein 2	Homo sapiens	254-282
31126456-2	2019	The objective of this study was to evaluate how selected techno-functional properties (gelation, emulsification) of SPH were affected by the presence of a non-gelling polysaccharide.	Polysaccharides	167-181	surfactant associated 3	Homo sapiens	116-119
31325506-0	2019	N-glycans of bovine submaxillary mucin contain core-fucosylated and sulfated glycans but not sialylated glycans.	Polysaccharides	77-84	mucin 1, cell surface associated	Bos taurus	33-38
31578522-9	2019	We also discovered that ligation of mannose-binding lectin (MBL), which binds to glycans of the fungal wall to activate the complement cascade, was required for oncogenic progression, whereas deletion of MBL or C3 in the extratumoral compartment-or knockdown of C3aR in tumour cells-were both protective against tumour growth.	Polysaccharides	81-88	mannose-binding lectin (protein C) 2	Mus musculus	36-58
31148596-7	2019	We also found that the scaffold protein mucosal addressin cell adhesion molecule 1 (MAdCAM-1), which is expressed on HEVs in PPs and MLNs but not PLNs, was modified by 297-11A-positive sulfated glycans less efficiently than was CD34.	Polysaccharides	194-201	mucosal vascular addressin cell adhesion molecule 1	Homo sapiens	84-92
31148596-7	2019	We also found that the scaffold protein mucosal addressin cell adhesion molecule 1 (MAdCAM-1), which is expressed on HEVs in PPs and MLNs but not PLNs, was modified by 297-11A-positive sulfated glycans less efficiently than was CD34.	Polysaccharides	194-201	CD34 molecule	Homo sapiens	228-232
31578522-9	2019	We also discovered that ligation of mannose-binding lectin (MBL), which binds to glycans of the fungal wall to activate the complement cascade, was required for oncogenic progression, whereas deletion of MBL or C3 in the extratumoral compartment-or knockdown of C3aR in tumour cells-were both protective against tumour growth.	Polysaccharides	81-88	mannose-binding lectin (protein C) 2	Mus musculus	60-63
31569686-9	2019	In particular, highly sialylated multi-branched glycans of serotransferrin serum were significantly correlated with poor prognosis and tumor stage in CCA patients.	Polysaccharides	48-55	transferrin	Homo sapiens	59-74
31180129-12	2019	Finally, anaerobic incubation of chicken mucin O-glycans with C. perfringens and subsequent analysis of the glycans revealed that there was preferential removal of Neu5Ac.	Polysaccharides	49-56	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	41-46
31341044-7	2019	Sialylated glycans and heparan sulfate chains covalently attached to the SPOCK2 core protein were critical for its antiviral activity.	Polysaccharides	11-18	sparc/osteonectin, cwcv and kazal-like domains proteoglycan 2	Mus musculus	73-79
33499919-13	2019	Microbial metabolic functions related to energy harvest, including glycan degradation, phosphotransferase systems and ABC transporters, were enriched in the ob/ob mice.	Polysaccharides	67-73	leptin	Mus musculus	4-6
31362986-4	2019	By coinfiltrating IgA with the respective glycan-modifying enzymes, we generated IgA carrying distinct homogenous N-glycans.	Polysaccharides	42-48	CD79a molecule	Homo sapiens	18-21
31362986-4	2019	By coinfiltrating IgA with the respective glycan-modifying enzymes, we generated IgA carrying distinct homogenous N-glycans.	Polysaccharides	42-48	CD79a molecule	Homo sapiens	81-84
31295484-0	2019	The ameliorations of Ganoderma applanatum residue polysaccharides against CCl4 induced liver injury.	Polysaccharides	50-65	chemokine (C-C motif) ligand 4	Mus musculus	74-78
31317190-2	2019	The structure Siaalpha2,6Galbeta1,4GlcNAc (Sia6LacNAc), synthesized by sialyltransferase ST6GAL1, is a cancer-associated glycan.	Polysaccharides	121-127	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	89-96
31265949-3	2019	Because the endogenous miR-155-5p has been ascribed to vasculoprotection, loading it onto positively charged, core-shell poly(isobutylcyanoacrylate) (PIBCA)-polysaccharide nanoparticles (NPs) was attempted.	Polysaccharides	157-171	microRNA 155	Homo sapiens	23-30
33499919-13	2019	Microbial metabolic functions related to energy harvest, including glycan degradation, phosphotransferase systems and ABC transporters, were enriched in the ob/ob mice.	Polysaccharides	67-73	leptin	Mus musculus	157-159
31151536-5	2019	TSF2 polysaccharide effectively induced RAW264.7 murine macrophages to release nitric oxide, TNF-alpha, IL-1beta and IL-6, and activated NK cells to produce TNF-alpha, INF-gamma, granzyme-B, perforin, NKG2D and FasL through NF-kappaB and MAPKs signaling pathways.	Polysaccharides	5-19	tumor necrosis factor	Mus musculus	93-102
30689704-2	2019	Multistage mass spectrometry (MSn) is a promising glycan identification technique as it generates multiple-level fragments of a glycan, which can be explored to deduce branching pattern of the glycan and further distinguish it from other candidates with identical mass.	Polysaccharides	50-56	moesin	Homo sapiens	30-33
30689704-2	2019	Multistage mass spectrometry (MSn) is a promising glycan identification technique as it generates multiple-level fragments of a glycan, which can be explored to deduce branching pattern of the glycan and further distinguish it from other candidates with identical mass.	Polysaccharides	128-134	moesin	Homo sapiens	30-33
30689704-2	2019	Multistage mass spectrometry (MSn) is a promising glycan identification technique as it generates multiple-level fragments of a glycan, which can be explored to deduce branching pattern of the glycan and further distinguish it from other candidates with identical mass.	Polysaccharides	128-134	moesin	Homo sapiens	30-33
30689704-3	2019	However, the automatic glycan identification still remains a challenge since it mainly relies on expertise to guide a MSn instrument to generate spectra.	Polysaccharides	23-29	moesin	Homo sapiens	118-121
30689704-4	2019	RESULTS: Here, we proposed a novel method, named bestFSA, based on a best-first search algorithm to guide the process of spectrum producing in glycan identification using MSn.	Polysaccharides	143-149	moesin	Homo sapiens	171-174
30689704-7	2019	The combination of the MSn technology coupled with bestFSA should greatly facilitate the automatic identification of glycan branching patterns, with significantly improved identification sensitivity, and reduce time and cost of MSn experiments.	Polysaccharides	117-123	moesin	Homo sapiens	23-26
31062865-5	2019	Using intact glycopeptide characterization, the EPO-Fc was observed to maintain their individual EPO and Fc N-glycan characteristics in which the EPO region presented bi-, tri-, and tetra-branched N-glycan structures, while the Fc N-glycan displayed mostly biantennary glycans.	Polysaccharides	269-276	erythropoietin	Cricetulus griseus	48-51
31180595-1	2019	beta-1,3-d-glucan with different degrees of branching were obtained by selectively and gradually removing side chains from schizophyllan, a water-soluble triple helical polysaccharide, using the Smith degradation.	Polysaccharides	169-183	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	0-8
31151509-8	2019	Our study suggests a novel approach for the development of polysaccharide-based agents that target Gal-3 function.	Polysaccharides	59-73	lectin, galactose binding, soluble 3	Mus musculus	99-104
31151536-5	2019	TSF2 polysaccharide effectively induced RAW264.7 murine macrophages to release nitric oxide, TNF-alpha, IL-1beta and IL-6, and activated NK cells to produce TNF-alpha, INF-gamma, granzyme-B, perforin, NKG2D and FasL through NF-kappaB and MAPKs signaling pathways.	Polysaccharides	5-19	interleukin 1 beta	Mus musculus	104-112
31151536-5	2019	TSF2 polysaccharide effectively induced RAW264.7 murine macrophages to release nitric oxide, TNF-alpha, IL-1beta and IL-6, and activated NK cells to produce TNF-alpha, INF-gamma, granzyme-B, perforin, NKG2D and FasL through NF-kappaB and MAPKs signaling pathways.	Polysaccharides	5-19	interleukin 6	Mus musculus	117-121
31151536-5	2019	TSF2 polysaccharide effectively induced RAW264.7 murine macrophages to release nitric oxide, TNF-alpha, IL-1beta and IL-6, and activated NK cells to produce TNF-alpha, INF-gamma, granzyme-B, perforin, NKG2D and FasL through NF-kappaB and MAPKs signaling pathways.	Polysaccharides	5-19	tumor necrosis factor	Mus musculus	157-166
31151536-5	2019	TSF2 polysaccharide effectively induced RAW264.7 murine macrophages to release nitric oxide, TNF-alpha, IL-1beta and IL-6, and activated NK cells to produce TNF-alpha, INF-gamma, granzyme-B, perforin, NKG2D and FasL through NF-kappaB and MAPKs signaling pathways.	Polysaccharides	5-19	granzyme B	Mus musculus	179-189
31151536-5	2019	TSF2 polysaccharide effectively induced RAW264.7 murine macrophages to release nitric oxide, TNF-alpha, IL-1beta and IL-6, and activated NK cells to produce TNF-alpha, INF-gamma, granzyme-B, perforin, NKG2D and FasL through NF-kappaB and MAPKs signaling pathways.	Polysaccharides	5-19	killer cell lectin-like receptor subfamily K, member 1	Mus musculus	201-206
31151536-5	2019	TSF2 polysaccharide effectively induced RAW264.7 murine macrophages to release nitric oxide, TNF-alpha, IL-1beta and IL-6, and activated NK cells to produce TNF-alpha, INF-gamma, granzyme-B, perforin, NKG2D and FasL through NF-kappaB and MAPKs signaling pathways.	Polysaccharides	5-19	Fas ligand (TNF superfamily, member 6)	Mus musculus	211-215
31158404-4	2019	The polysaccharide exhibited significant scavenging activities of ABTS and FRAP, as well as non-toxicity against human gastric epithelial GES-1 cells.	Polysaccharides	4-18	mechanistic target of rapamycin kinase	Homo sapiens	75-79
31844808-8	2019	IgA1-producing cells from patients with IgAV-N had altered expression of genes involved in O-glycan biosynthesis: decreased for core 1 synthase (glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; C1GALT1) and C1GALT1 Specific Chaperone 1 (C1GALTC1; COSMC) and elevated for N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2).	Polysaccharides	91-99	immunoglobulin heavy constant alpha 1	Homo sapiens	0-4
31158404-1	2019	The chemical characterization and protective role against ethanol-induced gastric ulcerated rats of a polysaccharide fraction from Bletilla striata (BSP) collected by ultrafiltration membrane approach were evaluated.	Polysaccharides	102-116	integrin binding sialoprotein	Homo sapiens	149-152
31102532-8	2019	Overexpression of the oncogenes MYC and MYCN recovered the slow growth in QD-KO and QT-KO without changing the glycan structures.	Polysaccharides	111-117	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	32-35
31102532-8	2019	Overexpression of the oncogenes MYC and MYCN recovered the slow growth in QD-KO and QT-KO without changing the glycan structures.	Polysaccharides	111-117	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	40-44
31390269-6	2019	After 4 weeks of feeding intervention with the polysaccharide, the immune and intestinal digestive ability of the ICR mice were significant as shown by the organ index, digestive enzymes, and reduction of serum tumor necrosis factor-alpha and diamine oxidase levels.	Polysaccharides	47-61	tumor necrosis factor	Mus musculus	211-238
31448992-0	2019	Polysaccharide of Atractylodes macrocephala Koidz Enhances Cytokine Secretion by Stimulating the TLR4-MyD88-NF-kappaB Signaling Pathway in the Mouse Spleen.	Polysaccharides	0-14	toll-like receptor 4	Mus musculus	97-101
31448992-0	2019	Polysaccharide of Atractylodes macrocephala Koidz Enhances Cytokine Secretion by Stimulating the TLR4-MyD88-NF-kappaB Signaling Pathway in the Mouse Spleen.	Polysaccharides	0-14	myeloid differentiation primary response gene 88	Mus musculus	102-107
31448992-0	2019	Polysaccharide of Atractylodes macrocephala Koidz Enhances Cytokine Secretion by Stimulating the TLR4-MyD88-NF-kappaB Signaling Pathway in the Mouse Spleen.	Polysaccharides	0-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	108-117
31448992-3	2019	The Toll-like receptor 4 (TLR4) signaling cascade has been proved as a classic polysaccharide-regulated pathway.	Polysaccharides	79-93	toll-like receptor 4	Mus musculus	4-24
31448992-3	2019	The Toll-like receptor 4 (TLR4) signaling cascade has been proved as a classic polysaccharide-regulated pathway.	Polysaccharides	79-93	toll-like receptor 4	Mus musculus	26-30
30077416-6	2019	The distinction in glycan specificity between the two peptide editors suggests that TAPBPR may bind to MHC class I molecules that are associated with a broader diversity of oligosaccharides attached compared with tapasin.	Polysaccharides	19-25	TAP binding protein like	Homo sapiens	84-90
31844808-8	2019	IgA1-producing cells from patients with IgAV-N had altered expression of genes involved in O-glycan biosynthesis: decreased for core 1 synthase (glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; C1GALT1) and C1GALT1 Specific Chaperone 1 (C1GALTC1; COSMC) and elevated for N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2).	Polysaccharides	91-99	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	128-210
31844808-8	2019	IgA1-producing cells from patients with IgAV-N had altered expression of genes involved in O-glycan biosynthesis: decreased for core 1 synthase (glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; C1GALT1) and C1GALT1 Specific Chaperone 1 (C1GALTC1; COSMC) and elevated for N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2).	Polysaccharides	91-99	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	212-219
31844808-8	2019	IgA1-producing cells from patients with IgAV-N had altered expression of genes involved in O-glycan biosynthesis: decreased for core 1 synthase (glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; C1GALT1) and C1GALT1 Specific Chaperone 1 (C1GALTC1; COSMC) and elevated for N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2).	Polysaccharides	91-99	C1GALT1 specific chaperone 1	Homo sapiens	225-253
31844808-8	2019	IgA1-producing cells from patients with IgAV-N had altered expression of genes involved in O-glycan biosynthesis: decreased for core 1 synthase (glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; C1GALT1) and C1GALT1 Specific Chaperone 1 (C1GALTC1; COSMC) and elevated for N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2).	Polysaccharides	91-99	C1GALT1 specific chaperone 1	Homo sapiens	255-263
31844808-8	2019	IgA1-producing cells from patients with IgAV-N had altered expression of genes involved in O-glycan biosynthesis: decreased for core 1 synthase (glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; C1GALT1) and C1GALT1 Specific Chaperone 1 (C1GALTC1; COSMC) and elevated for N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2).	Polysaccharides	91-99	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	Homo sapiens	344-354
31455323-3	2019	METHODS: CLEC10A ligands were detected in various tissues and cells using the recombinant glycan-binding domain of CLEC10A.	Polysaccharides	90-96	C-type lectin domain containing 10A	Homo sapiens	9-16
31466401-5	2019	High-mannose glycans are the natural ligands of dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), a dendritic cell associated C-type lectin receptor (CLR), which has the ability to efficiently internalize its cargo and direct it to both major histocompatibility complex (MHC)-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell responses, respectively.	Polysaccharides	13-20	CD209 molecule	Homo sapiens	48-127
31466401-5	2019	High-mannose glycans are the natural ligands of dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), a dendritic cell associated C-type lectin receptor (CLR), which has the ability to efficiently internalize its cargo and direct it to both major histocompatibility complex (MHC)-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell responses, respectively.	Polysaccharides	13-20	CD209 molecule	Homo sapiens	129-136
31466401-5	2019	High-mannose glycans are the natural ligands of dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), a dendritic cell associated C-type lectin receptor (CLR), which has the ability to efficiently internalize its cargo and direct it to both major histocompatibility complex (MHC)-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell responses, respectively.	Polysaccharides	13-20	C-type lectin domain family 4 member D	Homo sapiens	167-189
31466401-5	2019	High-mannose glycans are the natural ligands of dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), a dendritic cell associated C-type lectin receptor (CLR), which has the ability to efficiently internalize its cargo and direct it to both major histocompatibility complex (MHC)-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell responses, respectively.	Polysaccharides	13-20	C-type lectin domain family 4 member D	Homo sapiens	191-194
31466401-5	2019	High-mannose glycans are the natural ligands of dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), a dendritic cell associated C-type lectin receptor (CLR), which has the ability to efficiently internalize its cargo and direct it to both major histocompatibility complex (MHC)-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell responses, respectively.	Polysaccharides	13-20	CD8a molecule	Homo sapiens	360-363
31466401-5	2019	High-mannose glycans are the natural ligands of dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), a dendritic cell associated C-type lectin receptor (CLR), which has the ability to efficiently internalize its cargo and direct it to both major histocompatibility complex (MHC)-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell responses, respectively.	Polysaccharides	13-20	CD4 molecule	Homo sapiens	369-372
31455323-3	2019	METHODS: CLEC10A ligands were detected in various tissues and cells using the recombinant glycan-binding domain of CLEC10A.	Polysaccharides	90-96	C-type lectin domain containing 10A	Homo sapiens	115-122
31507595-2	2019	Soluble CD52 is released from the surface of activated T cells and mediates immune suppression via its glycan moiety.	Polysaccharides	103-109	CD52 molecule	Homo sapiens	8-12
31507595-4	2019	We aimed to identify the features of CD52 glycan that underlie its bioactivity.	Polysaccharides	42-48	CD52 molecule	Homo sapiens	37-41
31507595-10	2019	Understanding the structural features of CD52 glycan required for its bioactivity will aid its development as an immunotherapeutic agent.	Polysaccharides	46-52	CD52 molecule	Homo sapiens	41-45
31221341-6	2019	In addition, RAW264.7 cells produced large amounts of nitric oxide and various cytokines by up-regulating mRNA expression levels and the activation of nuclear factor-kappa (NF-kappaB) and mitogen-activated protein kinase (MAPK) after treatment with these polysaccharides.	Polysaccharides	255-270	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	173-182
31443712-3	2019	This study aimed to assess the glucose-lowering and hypolipidemic effects of polysaccharides from C. taii (CTP) in streptozotocin (STZ)-induced diabetic mice.	Polysaccharides	77-92	solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1	Mus musculus	107-110
31420549-6	2019	This retention is a means to spatially separate MNS3 from ER-localized mannose trimming steps that generate the glycan signal required for flagging terminally misfolded glycoproteins for ERAD.	Polysaccharides	112-118	alpha-mannosidase 3	Arabidopsis thaliana	48-52
31129217-1	2019	In this study, the purified water-soluble polysaccharide (ALP-1) from Arctium lappa was used to intervene lipopolysaccharide-induced RAW264.7 macrophage and systemic inflammatory mice.	Polysaccharides	42-56	apolipoprotein A-I	Mus musculus	58-63
31451706-4	2019	Here, we successfully established a novel glycan antibody for fucosylated AFP and demonstrated its potential clinical application.	Polysaccharides	42-48	alpha fetoprotein	Homo sapiens	74-77
31443488-1	2019	As a functional polysaccharide, inulin was carboxymethylated and it formed nanocomplexes with bovine serum albumin (BSA).	Polysaccharides	16-30	albumin	Homo sapiens	101-114
31353882-3	2019	To address this challenge, we developed a novel strategy for analysis of GSL-glycans from cultured cells based on a lectin microarray that can directly detect and reveal glycopatterns of GSL extracts without the need for glycan release.	Polysaccharides	77-83	cathepsin A	Homo sapiens	73-76
31176856-0	2019	Full-factorial central composite rotational design for the immobilization of lactase in natural polysaccharide-based hydrogels and hydrolysis of lactose.	Polysaccharides	96-110	lactase	Homo sapiens	77-84
31140679-2	2019	Siglec-7 shows preference for disialylated glycans, including alpha(2,8)-alpha(2,3)-disialic acids or internally branched alpha(2,6)-NeuAc, such as disialosylglobopentaose (DSGb5).	Polysaccharides	43-50	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
31327656-3	2019	Because PD-L1 is heavily glycosylated, we developed a method to resolve this by removing the glycan moieties from cell surface antigens via enzymatic digestion, a process termed sample deglycosylation.	Polysaccharides	93-99	CD274 molecule	Homo sapiens	8-13
31408003-4	2019	Human B cells secrete active ST6GAL1 sialyltransferase that remodels progenitor cell surface glycans to suppress granulopoiesis.	Polysaccharides	93-100	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	29-36
31140679-7	2019	Surprisingly, DSGb5 shows a low affinity for Siglec-7 in a glycan microarray binding affinity assay.	Polysaccharides	59-65	sialic acid binding Ig like lectin 7	Homo sapiens	45-53
31140679-8	2019	Among the synthesized globo-series glycans, alpha6alpha3DSGb4 shows the highest binding affinity for Siglec-7.	Polysaccharides	35-42	sialic acid binding Ig like lectin 7	Homo sapiens	101-109
31339142-3	2019	Glycan microarray binding studies indicate that Siglec-7 does not recognize DSGb5, and preferentially binds Neu5Acalpha(2,8)Neu5Ac containing glycans.	Polysaccharides	0-6	sialic acid binding Ig like lectin 7	Homo sapiens	48-56
31412567-4	2019	The four purified polysaccharides (Pe1, Pe2, Pe3, Pe4) from TCBL are mainly composed of arabinose, galactose, glucose, a small amount of xylose, and mannose.	Polysaccharides	18-33	ETS variant transcription factor 3	Homo sapiens	35-38
31412567-4	2019	The four purified polysaccharides (Pe1, Pe2, Pe3, Pe4) from TCBL are mainly composed of arabinose, galactose, glucose, a small amount of xylose, and mannose.	Polysaccharides	18-33	ETS2 repressor factor	Homo sapiens	40-43
31489145-8	2019	Surprisingly, however, glioblastoma EVs lack glycans that could bind Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN, CD209), a receptor that mediates uptake and induction of CD4+ and CD8+ T cell activation.	Polysaccharides	45-52	CD209 molecule	Homo sapiens	69-148
31489145-8	2019	Surprisingly, however, glioblastoma EVs lack glycans that could bind Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN, CD209), a receptor that mediates uptake and induction of CD4+ and CD8+ T cell activation.	Polysaccharides	45-52	CD209 molecule	Homo sapiens	150-157
31246420-4	2019	Here we take a multiple reaction monitoring (MRM) approach to differentiate and relatively quantify all detectable glycans, including isomers, on the heavily O-glycosylated protein lubricin.	Polysaccharides	115-122	proteoglycan 4	Homo sapiens	181-189
31339142-3	2019	Glycan microarray binding studies indicate that Siglec-7 does not recognize DSGb5, and preferentially binds Neu5Acalpha(2,8)Neu5Ac containing glycans.	Polysaccharides	142-149	sialic acid binding Ig like lectin 7	Homo sapiens	48-56
31296534-6	2019	Remarkably, the lumenal ER chaperone GRP94 was hyperglycosylated in STT3A-deficient cells, bearing glycans on five silent sites in addition to the normal glycosylation site.	Polysaccharides	99-106	heat shock protein 90 beta family member 1	Homo sapiens	37-42
31296534-6	2019	Remarkably, the lumenal ER chaperone GRP94 was hyperglycosylated in STT3A-deficient cells, bearing glycans on five silent sites in addition to the normal glycosylation site.	Polysaccharides	99-106	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	68-73
30905597-5	2019	We found that silencing of ALCAM in MDA-MB-231 triple negative breast cancer cells decreases cell adhesion and migration onto Gal-8-coated surfaces in a glycan-dependent fashion.	Polysaccharides	153-159	activated leukocyte cell adhesion molecule	Homo sapiens	27-32
31266306-4	2019	Among them, trisialylated monofucosylated triantennary glycan (A3F) of alpha-1 antitrypsin showed the most dynamic change.	Polysaccharides	55-61	serpin family A member 1	Homo sapiens	71-90
31190240-1	2019	AmyC, a glycoside hydrolase family 57 (GH57) enzyme of Thermotoga maritima MSB8, has previously been identified as an intracellular alpha-amylase playing a role in either maltodextrin utilization or storage polysaccharide metabolism.	Polysaccharides	207-221	alpha-amylase	Thermotoga maritima MSB8	132-145
30905597-5	2019	We found that silencing of ALCAM in MDA-MB-231 triple negative breast cancer cells decreases cell adhesion and migration onto Gal-8-coated surfaces in a glycan-dependent fashion.	Polysaccharides	153-159	galectin 8	Homo sapiens	126-131
31128937-8	2019	The sealer with 5% DMAHDM and 0.15% NAg greatly reduced polysaccharide production by the biofilms, and decreased the biofilm CFU by nearly 6 orders of magnitude, compared to AH Plus and experimental controls (p &lt; 0.05).	Polysaccharides	56-70	NBAS subunit of NRZ tethering complex	Homo sapiens	36-39
31154271-0	2019	White mulberry fruit polysaccharides enhance endothelial nitric oxide production to relax arteries in vitro and reduce blood pressure in vivo.	Polysaccharides	21-36	relaxin 1	Rattus norvegicus	84-89
31155547-2	2019	The aim of this study was to evaluate the anti-diabetic effect of acidic polysaccharide from Schisandra chinensis (SCAP).	Polysaccharides	73-87	SREBF chaperone	Rattus norvegicus	115-119
31314026-0	2019	A novel polysaccharide obtained from Craterellus cornucopioides enhances immunomodulatory activity in immunosuppressive mice models via regulation of the TLR4-NF-kappaB pathway.	Polysaccharides	8-22	toll-like receptor 4	Mus musculus	154-158
31123037-8	2019	Gene-metabolite networks revealed a positive association between the hepatic glycan synthesis gene alpha-1,6-mannosyltransferase (Alg12) mRNA and mannose, which are important for protein glycosylation.	Polysaccharides	77-83	asparagine-linked glycosylation 12 (alpha-1,6-mannosyltransferase)	Mus musculus	130-135
31271519-5	2019	Therefore, we analyzed the interactions of FGF1 and FGF2 with four sulfated polysaccharides: heparin, dextran sulfate (DXS), lambda-carrageenan, and chondroitin sulfate.	Polysaccharides	76-91	fibroblast growth factor 1	Homo sapiens	43-47
31271519-5	2019	Therefore, we analyzed the interactions of FGF1 and FGF2 with four sulfated polysaccharides: heparin, dextran sulfate (DXS), lambda-carrageenan, and chondroitin sulfate.	Polysaccharides	76-91	fibroblast growth factor 2	Homo sapiens	52-56
30733320-5	2019	Methods: Since the heavy chain glycans influence the affinity of FcgammaR for the Fc domain, we set out to investigate whether radioimmunoconjugates with truncated glycans would exhibit altered binding to FcgammaRI and, in turn, improved in vivo performance.	Polysaccharides	164-171	Fc gamma receptor Ia	Homo sapiens	205-214
31355400-0	2019	Water-soluble polysaccharides from Grifola Frondosa fruiting bodies protect against immunosuppression in cyclophosphamide-induced mice via JAK2/STAT3/SOCS signal transduction pathways.	Polysaccharides	14-29	Janus kinase 2	Mus musculus	139-143
31355400-0	2019	Water-soluble polysaccharides from Grifola Frondosa fruiting bodies protect against immunosuppression in cyclophosphamide-induced mice via JAK2/STAT3/SOCS signal transduction pathways.	Polysaccharides	14-29	signal transducer and activator of transcription 3	Mus musculus	144-149
31355400-0	2019	Water-soluble polysaccharides from Grifola Frondosa fruiting bodies protect against immunosuppression in cyclophosphamide-induced mice via JAK2/STAT3/SOCS signal transduction pathways.	Polysaccharides	14-29	cytokine inducible SH2-containing protein	Mus musculus	150-154
31298688-7	2019	In addition, in these regions, we also found several genes involved in the protein catabolic process (UBE4A and LONP1), lipid metabolism (ACOT1), glycan biosynthesis and metabolism (HYAL1 and HYAL4), and the immune system (JAM2) that are likely to promote the normal development of embryos and nestlings.	Polysaccharides	146-152	junctional adhesion molecule B	Nipponia nippon	223-227
31071400-0	2019	Inhibiting c-Jun N-terminal kinase (JNK)-mediated apoptotic signaling pathway in PC12 cells by a polysaccharide (CCP) from Coptis chinensis against Amyloid-beta (Abeta)-induced neurotoxicity.	Polysaccharides	97-111	mitogen-activated protein kinase 8	Rattus norvegicus	11-34
31071400-0	2019	Inhibiting c-Jun N-terminal kinase (JNK)-mediated apoptotic signaling pathway in PC12 cells by a polysaccharide (CCP) from Coptis chinensis against Amyloid-beta (Abeta)-induced neurotoxicity.	Polysaccharides	97-111	mitogen-activated protein kinase 8	Rattus norvegicus	36-39
31075333-0	2019	The protective effects of a novel polysaccharide from Lentinus edodes mycelia on islet beta (INS-1) cells damaged by glucose and its transportation mechanism with human serum albumin.	Polysaccharides	34-48	albumin	Rattus norvegicus	169-182
31074668-0	2019	Pretreatment with Salvia miltiorrhiza Polysaccharides Protects from Lipopolysaccharides/d-Galactosamine-Induced Liver Injury in Mice Through Inhibiting TLR4/MyD88 Signaling Pathway.	Polysaccharides	38-53	toll-like receptor 4	Mus musculus	152-156
31074668-0	2019	Pretreatment with Salvia miltiorrhiza Polysaccharides Protects from Lipopolysaccharides/d-Galactosamine-Induced Liver Injury in Mice Through Inhibiting TLR4/MyD88 Signaling Pathway.	Polysaccharides	38-53	myeloid differentiation primary response gene 88	Mus musculus	157-162
30729651-4	2019	Here, we describe the production in plants and anti-HIV activity of a novel bispecific fusion protein consisting of the antigen-binding fragment (Fab) of the CD4 binding site-specific bNAb VRC01 and the antiviral lectin Avaren, which targets the glycan shield of the HIV-1 envelope (VRC01Fab -Avaren).	Polysaccharides	246-252	FA complementation group B	Homo sapiens	146-149
31194867-9	2019	Purified galectin-3 is capable of binding to ZP, indicating that galectin-3 may serve as a cross-linking bridge between ZP glycans and sperm surface glycoproteins.	Polysaccharides	123-130	galectin 3	Homo sapiens	9-19
31194867-9	2019	Purified galectin-3 is capable of binding to ZP, indicating that galectin-3 may serve as a cross-linking bridge between ZP glycans and sperm surface glycoproteins.	Polysaccharides	123-130	galectin 3	Homo sapiens	65-75
30729651-4	2019	Here, we describe the production in plants and anti-HIV activity of a novel bispecific fusion protein consisting of the antigen-binding fragment (Fab) of the CD4 binding site-specific bNAb VRC01 and the antiviral lectin Avaren, which targets the glycan shield of the HIV-1 envelope (VRC01Fab -Avaren).	Polysaccharides	246-252	CD4 molecule	Homo sapiens	158-161
30973212-0	2019	Yupingfeng polysaccharides enhances growth performance in Qingyuan partridge chicken by up-regulating the mRNA expression of SGLT1, GLUT2 and GLUT5.	Polysaccharides	11-26	solute carrier family 5 member 1	Gallus gallus	125-130
31371767-2	2019	Recent studies have shown that cell wall polysaccharides of Malassezia are detected by the immune system via the C-type lectin receptors Dectin-1 and Dectin-2, which are expressed on myeloid cells.	Polysaccharides	41-56	C-type lectin domain containing 7A	Homo sapiens	137-145
31371767-2	2019	Recent studies have shown that cell wall polysaccharides of Malassezia are detected by the immune system via the C-type lectin receptors Dectin-1 and Dectin-2, which are expressed on myeloid cells.	Polysaccharides	41-56	C-type lectin domain containing 6A	Homo sapiens	150-158
30973212-0	2019	Yupingfeng polysaccharides enhances growth performance in Qingyuan partridge chicken by up-regulating the mRNA expression of SGLT1, GLUT2 and GLUT5.	Polysaccharides	11-26	solute carrier family 2 member 2	Gallus gallus	132-137
30973212-2	2019	This study was conducted to evaluate the effects of Yupingfeng polysaccharides (YP) supplementation on growth performance and expression of SGLT1, GLUT2 and GLUT5 in Qingyuan partridge chicken.	Polysaccharides	63-78	solute carrier family 5 member 1	Gallus gallus	140-145
30973212-2	2019	This study was conducted to evaluate the effects of Yupingfeng polysaccharides (YP) supplementation on growth performance and expression of SGLT1, GLUT2 and GLUT5 in Qingyuan partridge chicken.	Polysaccharides	63-78	solute carrier family 2 member 2	Gallus gallus	147-152
31349728-5	2019	Methods: Sequel to our team"s previous publication, the present study explores probable effects of Astragalus polysaccharides (PG2) on cancer-related inflammatory landscape and known determinants of QoL, as well as the probable link between the two to provide mechanistic insight.	Polysaccharides	110-125	delta like non-canonical Notch ligand 1	Homo sapiens	127-130
31257333-0	2019	Polysaccharides from Enteromorpha Prolifera Ameliorate Acute Myocardial Infarction in Vitro and in Vivo via Up-Regulating HIF-1alpha.	Polysaccharides	0-15	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	122-132
30943746-0	2019	Acanthopanax senticosus polysaccharide suppressing proliferation and metastasis of the human non-small cell lung cancer NCI-H520 cells is associated with Wnt/beta-catenin signaling.	Polysaccharides	24-38	catenin beta 1	Homo sapiens	158-170
31357461-2	2019	Cereal beta-glucans have a specific combination of beta-(1 4) and beta-(1 3) linkages into linear long-chain polysaccharides of high molecular weight.	Polysaccharides	109-124	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	51-60
31357461-2	2019	Cereal beta-glucans have a specific combination of beta-(1 4) and beta-(1 3) linkages into linear long-chain polysaccharides of high molecular weight.	Polysaccharides	109-124	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	66-75
31372513-0	2019	Ability of prebiotic polysaccharides to activate a HIF1alpha-antimicrobial peptide axis determines liver injury risk in zebrafish.	Polysaccharides	21-36	hypoxia inducible factor 1 subunit alpha a	Danio rerio	51-60
31372513-6	2019	Finally, we find that liver injury risk is not confined to Lactobacillus-derived EPS but extends to other types of commonly used natural polysaccharides, depending on their HIF1alpha activation efficiency.	Polysaccharides	137-152	hypoxia inducible factor 1 subunit alpha a	Danio rerio	173-182
31329635-4	2019	In order to determine the role of Fut2-dependent glycans in Salmonella-triggered intestinal inflammation, Fut2+/+ and Fut2-/- mice were orally infected with S. Typhimurium and bacterial colonization and intestinal inflammation were analyzed.	Polysaccharides	49-56	fucosyltransferase 2	Mus musculus	34-38
31091305-4	2019	With adhesion/growth-regulatory human galectin-1 as example, the strategy of evaluating how changes of its design (here, from the homodimer of non-covalently associated domains to (i) linker-connected di- and tetramers and (ii) a galectin-3-like protein) affect activity is illustrated by using three assay systems of increasing degree of glycan complexity.	Polysaccharides	339-345	galectin 1	Homo sapiens	38-48
31336597-5	2019	In this study, the structure and influence of the neutral polysaccharide from Pseuderanthemum carruthersii (PCA1) on lipopolysaccharide (LPS)-stimulated RAW264.7 cells were investigated.	Polysaccharides	58-72	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mus musculus	108-112
31118252-5	2019	First, we found that P domain proteins of GII.13/21 huNoVs circulating at different times bound three glycans sharing a common terminal beta-Gal, including Lec, lactose, and mucin core 2.	Polysaccharides	102-109	C-C motif chemokine ligand 16	Homo sapiens	156-159
31179689-5	2019	Here, we present a workflow for the analysis of procainamide-labeled GSL glycans using HILIC-IM-MS and a new, automated glycan identification strategy whereby multiple glycan attributes are combined to increase accuracy in automated structural assignments.	Polysaccharides	73-79	cathepsin A	Homo sapiens	69-72
31179689-6	2019	For glycan matching and identification, an experimental reference database of GSL glycans containing GU, mass, and CCS values for each glycan was created.	Polysaccharides	82-88	cathepsin A	Homo sapiens	78-81
31187982-9	2019	We demonstrate that NGGM generates glycan-GBP binding data that are consistent with that generated in a slide-based glycan microarray.	Polysaccharides	35-41	transmembrane protein 132A	Homo sapiens	42-45
30919527-5	2019	These results assess the ability of MGL to recognise glycan moieties exposed on Gram-negative bacterial surfaces.	Polysaccharides	53-59	C-type lectin domain containing 10A	Homo sapiens	36-39
30998950-5	2019	In mice serum, the levels of cytokines including TNF-alpha, IFN-gamma and IL-10 restored and the contents of hemolysin were also found elevated after treatment with polysaccharide and its iron complex.	Polysaccharides	165-179	tumor necrosis factor	Mus musculus	49-58
30998950-5	2019	In mice serum, the levels of cytokines including TNF-alpha, IFN-gamma and IL-10 restored and the contents of hemolysin were also found elevated after treatment with polysaccharide and its iron complex.	Polysaccharides	165-179	interferon gamma	Mus musculus	60-69
30998950-5	2019	In mice serum, the levels of cytokines including TNF-alpha, IFN-gamma and IL-10 restored and the contents of hemolysin were also found elevated after treatment with polysaccharide and its iron complex.	Polysaccharides	165-179	interleukin 10	Mus musculus	74-79
31126942-7	2019	Two genes (bglA and bglB; Atu2295 and Atu4561) encode proteins with beta-glycosidase activity and could digest a variety of plant cell wall oligosaccharides and polysaccharides.	Polysaccharides	161-176	glycoside hydrolase family 105 protein	Agrobacterium fabrum str. C58	38-45
30981770-1	2019	The effects of a polysaccharide (DAP) from the roots of Dipsacus asper on renal complication in streptozotocin (STZ)-induced diabetic rats were investigated in the present study.	Polysaccharides	17-31	death-associated protein	Rattus norvegicus	33-36
30986453-3	2019	CAP-3, an acidic polysaccharide with a molecular weight of 121.34 kDa, was separated and purified from CAPs, which was only composed of glucose and mannose.	Polysaccharides	17-31	serine (or cysteine) peptidase inhibitor, clade B, member 9	Mus musculus	0-5
31118252-10	2019	Unlike the previous findings that GII.13/21 genotypes recognize only Lea antigen, we found in this study that they can interact with a group of glycans with a common terminal beta-Gal, including Lec, lactose, and mucin core 2.	Polysaccharides	144-151	C-C motif chemokine ligand 16	Homo sapiens	195-198
31079966-1	2019	Structural and functional effects of core M1 type glycan modification catalyzed by protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) were investigated using a core M1 glycoform focused library of an alpha-dystroglycan fragment, 372TRGAIIQTPTLGPIQPTRV390.	Polysaccharides	50-56	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	Homo sapiens	83-149
31291272-0	2019	A preliminary study on the application of PspA as a carrier for group A meningococcal polysaccharide.	Polysaccharides	86-100	surfactant associated protein A1	Mus musculus	42-46
31288400-4	2019	It was found that the polysaccharides possess anti-proliferative activity on LNCaP and PC3 cells, with a 50% growth inhibition (IC50) value as low as 0.61 mg/mL in LNCaP.	Polysaccharides	22-37	chromobox 8	Homo sapiens	87-90
31428354-1	2019	This study aimed to investigate structural features and antihyperlipidemic effects of the stigma maydis polysaccharide, termed SMP-1.	Polysaccharides	104-118	sperm associated antigen 8	Mus musculus	127-132
31379992-10	2019	Also, the analysis correlated with induced cell death elucidated that concurrent treatment of polysaccharide plus paclitaxel had a further anti-cancer effect against A2780cp cells mainly through restoration of p53 and mitochondrial apoptosis cell death induction.	Polysaccharides	94-108	tumor protein p53	Homo sapiens	210-213
31079966-1	2019	Structural and functional effects of core M1 type glycan modification catalyzed by protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase 1 (POMGnT1) were investigated using a core M1 glycoform focused library of an alpha-dystroglycan fragment, 372TRGAIIQTPTLGPIQPTRV390.	Polysaccharides	50-56	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	Homo sapiens	151-158
30759204-0	2019	IgA1 hinge-region clustered glycan fidelity is established early during semi-ordered glycosylation by GalNAc-T2.	Polysaccharides	28-34	immunoglobulin heavy constant alpha 1	Homo sapiens	0-4
30981354-0	2019	Polysaccharide-based adsorbents prepared in ionic liquid with high performance for removing Pb(II) from aqueous systems.	Polysaccharides	0-14	submaxillary gland androgen regulated protein 3B	Homo sapiens	92-98
30981359-0	2019	Preliminary characterization, antioxidant and alpha-glucosidase inhibitory activities of polysaccharides from Mallotus furetianus.	Polysaccharides	89-104	sucrase-isomaltase	Homo sapiens	46-63
30759204-0	2019	IgA1 hinge-region clustered glycan fidelity is established early during semi-ordered glycosylation by GalNAc-T2.	Polysaccharides	28-34	polypeptide N-acetylgalactosaminyltransferase 2	Homo sapiens	102-111
30759204-2	2019	Observed IgA1 glycosylation patterns show that glycans occur at similar sites with similar structures.	Polysaccharides	47-54	immunoglobulin heavy constant alpha 1	Homo sapiens	9-13
30759204-5	2019	In IgA nephropathy, an autoimmune disease, the sites and O-glycan structures of IgA1 hinge-region are altered, giving rise to a glycan autoantigen.	Polysaccharides	59-65	immunoglobulin heavy constant alpha 1	Homo sapiens	80-84
30759204-11	2019	The lectin domain predominately enhanced IgA1 HR glycan density by increasing synthesis pathway exploration by GalNAc-T2.	Polysaccharides	49-55	immunoglobulin heavy constant alpha 1	Homo sapiens	41-45
30759204-11	2019	The lectin domain predominately enhanced IgA1 HR glycan density by increasing synthesis pathway exploration by GalNAc-T2.	Polysaccharides	49-55	polypeptide N-acetylgalactosaminyltransferase 2	Homo sapiens	111-120
30759204-12	2019	Our data indicated a link between site-specific glycan addition and clustered glycan density that defines a mechanism of how conserved clustered O-glycosylation patterns and glycoform populations of IgA1 can be controlled by GalNAc-T2.	Polysaccharides	48-54	immunoglobulin heavy constant alpha 1	Homo sapiens	199-203
30759204-12	2019	Our data indicated a link between site-specific glycan addition and clustered glycan density that defines a mechanism of how conserved clustered O-glycosylation patterns and glycoform populations of IgA1 can be controlled by GalNAc-T2.	Polysaccharides	48-54	polypeptide N-acetylgalactosaminyltransferase 2	Homo sapiens	225-234
30759204-12	2019	Our data indicated a link between site-specific glycan addition and clustered glycan density that defines a mechanism of how conserved clustered O-glycosylation patterns and glycoform populations of IgA1 can be controlled by GalNAc-T2.	Polysaccharides	78-84	immunoglobulin heavy constant alpha 1	Homo sapiens	199-203
30759204-12	2019	Our data indicated a link between site-specific glycan addition and clustered glycan density that defines a mechanism of how conserved clustered O-glycosylation patterns and glycoform populations of IgA1 can be controlled by GalNAc-T2.	Polysaccharides	78-84	polypeptide N-acetylgalactosaminyltransferase 2	Homo sapiens	225-234
30954593-0	2019	Hepatoprotective effect of a polysaccharide from Radix Cyathulae officinalis Kuan against CCl4-induced acute liver injury in rat.	Polysaccharides	29-43	C-C motif chemokine ligand 4	Rattus norvegicus	90-94
30936012-6	2019	FI-TR indicated SP1-1 had the characteristic absorption of polysaccharides with a pyranoid ring.	Polysaccharides	59-74	trans-acting transcription factor 1	Mus musculus	16-21
30936009-0	2019	Characterization of Moringa oleifera roots polysaccharide MRP-1 with anti-inflammatory effect.	Polysaccharides	43-57	prolactin family 2, subfamily c, member 2	Mus musculus	58-63
30936009-2	2019	This work aimed to get a novel polysaccharide, termed MRP-1, which was isolated from Moringa oleifera roots with hot water extraction method followed by ethanol precipitation and purified with DEAE-Sepharose Fast Flow column.	Polysaccharides	31-45	prolactin family 2, subfamily c, member 2	Mus musculus	54-59
30954593-2	2019	The aim of this study is to investigate the hepatoprotective effects of polysaccharide from Radix Cyathulae officinalis Kuan (RCPS) against CCl4-induced liver damage in rat.	Polysaccharides	72-86	C-C motif chemokine ligand 4	Rattus norvegicus	140-144
30999209-4	2019	To our surprise, the single most important factor determining binding strength was a close vicinity of several TF glycans at distances of <=1 nm.	Polysaccharides	114-121	coagulation factor III, tissue factor	Homo sapiens	111-113
31353707-2	2019	A neutral polysaccharide (DIP-1) from Duchesnea indica (Andr.)	Polysaccharides	10-24	cyclin D1 binding protein 1	Homo sapiens	26-31
32641963-4	2019	polysaccharide (LBP) is the main active fraction purified from Lycium barbarum.	Polysaccharides	0-14	lipopolysaccharide binding protein	Mus musculus	16-19
31359698-2	2019	In this study,homogeneous polysaccharides were isolated from Poria cocos and their sulfated derivatives were prepared to screen out the polysaccharide compositions with inhibitory effects on SATB1 expression.	Polysaccharides	26-41	SATB homeobox 1	Homo sapiens	191-196
30990348-1	2019	Typical crystallizable fragment (Fc) glycans attached to the CH2 domain in therapeutic monoclonal antibodies (mAbs) are core-fucosylated and asialo-biantennary complex-type glycans, e.g., G2F (full galactosylation), G1aF (terminal galactosylation on the Man alpha1-6 arm), G1bF (terminal galactosylation on the Man alpha1-3 arm), and G0F (non-galactosylation).	Polysaccharides	37-44	adrenoceptor alpha 1D	Homo sapiens	258-266
30990348-1	2019	Typical crystallizable fragment (Fc) glycans attached to the CH2 domain in therapeutic monoclonal antibodies (mAbs) are core-fucosylated and asialo-biantennary complex-type glycans, e.g., G2F (full galactosylation), G1aF (terminal galactosylation on the Man alpha1-6 arm), G1bF (terminal galactosylation on the Man alpha1-3 arm), and G0F (non-galactosylation).	Polysaccharides	37-44	adrenoceptor alpha 1D	Homo sapiens	315-323
30990348-1	2019	Typical crystallizable fragment (Fc) glycans attached to the CH2 domain in therapeutic monoclonal antibodies (mAbs) are core-fucosylated and asialo-biantennary complex-type glycans, e.g., G2F (full galactosylation), G1aF (terminal galactosylation on the Man alpha1-6 arm), G1bF (terminal galactosylation on the Man alpha1-3 arm), and G0F (non-galactosylation).	Polysaccharides	173-180	adrenoceptor alpha 1D	Homo sapiens	258-266
30990348-1	2019	Typical crystallizable fragment (Fc) glycans attached to the CH2 domain in therapeutic monoclonal antibodies (mAbs) are core-fucosylated and asialo-biantennary complex-type glycans, e.g., G2F (full galactosylation), G1aF (terminal galactosylation on the Man alpha1-6 arm), G1bF (terminal galactosylation on the Man alpha1-3 arm), and G0F (non-galactosylation).	Polysaccharides	173-180	adrenoceptor alpha 1D	Homo sapiens	315-323
30976088-4	2019	We observed that TNC binding and neutralization of HIV-1 is dependent on the TNC fibrinogen-like globe (fbg) and fibronectin-type III (fn) domains, oligomerization, and its newly-mapped glycan structure.	Polysaccharides	186-192	tenascin C	Homo sapiens	17-20
30976088-5	2019	Moreover, we observed that TNC-mediated neutralization is also dependent on Env V3 residues 321/322 and 326/327, which surround the IGDIR motif of the V3 loop, as well the N332 glycan, which is critical to the broadly neutralizing activity of glycan-dependent V3-specific antibodies such as PGT128.	Polysaccharides	177-183	tenascin C	Homo sapiens	27-30
30976088-5	2019	Moreover, we observed that TNC-mediated neutralization is also dependent on Env V3 residues 321/322 and 326/327, which surround the IGDIR motif of the V3 loop, as well the N332 glycan, which is critical to the broadly neutralizing activity of glycan-dependent V3-specific antibodies such as PGT128.	Polysaccharides	243-249	tenascin C	Homo sapiens	27-30
31061498-0	2019	Glycan sulfation patterns define autophagy flux at axon tip via PTPRsigma-cortactin axis.	Polysaccharides	0-6	cortactin	Homo sapiens	74-83
31359698-2	2019	In this study,homogeneous polysaccharides were isolated from Poria cocos and their sulfated derivatives were prepared to screen out the polysaccharide compositions with inhibitory effects on SATB1 expression.	Polysaccharides	26-40	SATB homeobox 1	Homo sapiens	191-196
31359698-10	2019	In addition,it was found that polysaccharide of P. cocos and its sulfated derivative can inhibit expression of SATB1.	Polysaccharides	30-44	SATB homeobox 1	Homo sapiens	111-116
31168531-5	2019	Moreover, all the polysaccharides showed good alpha-glucosidase inhibitory activities except for MFPu with the lowest molecular weight.	Polysaccharides	18-33	sucrase-isomaltase	Homo sapiens	46-63
31089602-1	2019	This study aimed to evaluate the regulation of lipid metabolism and mechanism of a sulfated polysaccharide from Gracilaria Lemaneiformis (GLP).	Polysaccharides	92-106	euchromatic histone methyltransferase 1	Mus musculus	138-141
31089650-0	2019	Protective effects of polysaccharides from Cordyceps gunnii mycelia against cyclophosphamide-induced immunosuppression to TLR4/TRAF6/NF-kappaB signalling in BALB/c mice.	Polysaccharides	22-37	toll-like receptor 4	Mus musculus	122-126
31297112-0	2019	S-Layer Glycoprotein From Lactobacillus kefiri Exerts Its Immunostimulatory Activity Through Glycan Recognition by Mincle.	Polysaccharides	93-99	C-type lectin domain family 4, member e	Mus musculus	115-121
31297112-6	2019	Here, using a mild periodate oxidation protocol, we showed that loss of SLP-8348 glycan integrity impairs the cell-mediated immune response against the protein.	Polysaccharides	81-87	superkiller viralicidic activity 2-like (S. cerevisiae), pseudogene 1	Mus musculus	72-75
31297112-7	2019	Moreover, our data indicate that the adjuvant capacity of SLP-8348 is also dependent of the biological activity of the SLP-8348 glycans.	Polysaccharides	128-135	superkiller viralicidic activity 2-like (S. cerevisiae), pseudogene 1	Mus musculus	58-61
31297112-7	2019	Moreover, our data indicate that the adjuvant capacity of SLP-8348 is also dependent of the biological activity of the SLP-8348 glycans.	Polysaccharides	128-135	superkiller viralicidic activity 2-like (S. cerevisiae), pseudogene 1	Mus musculus	119-122
31242623-1	2019	A fluorine nuclear magnetic resonance (19F-NMR)-based method is employed to assess the binding preferences and interaction details of a library of synthetic fluorinated monosaccharides towards dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN), a lectin of biomedical interest, which is involved in different viral infections, including HIV and Ebola, and is able to recognize a variety of self- and non-self-glycans.	Polysaccharides	448-455	CD209 molecule	Homo sapiens	193-272
31428526-4	2019	Here we show that human luminal breast cancer (LBC) clusterin also bears terminal fucosylated glycans, conferring clusterin the ability to interact with DC-SIGN, a C-type lectin receptor expressed by myeloid cells.	Polysaccharides	94-101	clusterin	Homo sapiens	52-61
31428526-4	2019	Here we show that human luminal breast cancer (LBC) clusterin also bears terminal fucosylated glycans, conferring clusterin the ability to interact with DC-SIGN, a C-type lectin receptor expressed by myeloid cells.	Polysaccharides	94-101	clusterin	Homo sapiens	114-123
31428526-4	2019	Here we show that human luminal breast cancer (LBC) clusterin also bears terminal fucosylated glycans, conferring clusterin the ability to interact with DC-SIGN, a C-type lectin receptor expressed by myeloid cells.	Polysaccharides	94-101	CD209 molecule	Homo sapiens	153-160
31428526-4	2019	Here we show that human luminal breast cancer (LBC) clusterin also bears terminal fucosylated glycans, conferring clusterin the ability to interact with DC-SIGN, a C-type lectin receptor expressed by myeloid cells.	Polysaccharides	94-101	C-type lectin domain family 4 member D	Homo sapiens	164-186
31089650-0	2019	Protective effects of polysaccharides from Cordyceps gunnii mycelia against cyclophosphamide-induced immunosuppression to TLR4/TRAF6/NF-kappaB signalling in BALB/c mice.	Polysaccharides	22-37	TNF receptor-associated factor 6	Mus musculus	127-132
31089650-0	2019	Protective effects of polysaccharides from Cordyceps gunnii mycelia against cyclophosphamide-induced immunosuppression to TLR4/TRAF6/NF-kappaB signalling in BALB/c mice.	Polysaccharides	22-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	133-142
31089650-2	2019	In this study, the aim was to investigate the effect of polysaccharides from Cordyceps gunnii mycelia (PPS) in cyclophosphamide (CTX)-induced immunodeficient mice.	Polysaccharides	56-71	V-set and immunoglobulin domain containing 2	Mus musculus	129-132
31126879-3	2019	SF12 recognized a glycan-dominated epitope on Env"s silent face and was potent against clade AE viruses, which are poorly covered by V3-glycan bNAbs.	Polysaccharides	18-24	endogenous retrovirus group K member 20	Homo sapiens	46-49
31216697-3	2019	A major constituent of bacterial septa and of the whole cell wall is peptidoglycan (PGN), an essential cell wall polymer, formed by glycan chains of beta-(1-4)-linked-N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc), cross-linked by short peptide stems.	Polysaccharides	76-82	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	149-158
31244828-11	2019	We determined the glycan structure of MOG produced in HEK cells by mass spectrometry.	Polysaccharides	18-24	myelin oligodendrocyte glycoprotein	Homo sapiens	38-41
30857966-0	2019	Characterization of polysaccharide from Scutellaria barbata and its antagonistic effect on the migration and invasion of HT-29 colorectal cancer cells induced by TGF-beta1.	Polysaccharides	20-34	transforming growth factor beta 1	Homo sapiens	162-171
30996092-5	2019	Glycan binding preference analyses suggested that, similar to other avian-origin H10 IAVs, these gull-origin H10N7 IAVs bound to both avian-like alpha 2,3-linked sialic acids and human-like alpha 2,6-linked sialic acids.	Polysaccharides	0-6	H1.0 linker histone	Homo sapiens	81-84
30878614-0	2019	Inonotus obliquus polysaccharides protect against Alzheimer"s disease by regulating Nrf2 signaling and exerting antioxidative and antiapoptotic effects.	Polysaccharides	18-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	84-88
31196042-0	2019	The protective effects of polysaccharide extract from Xin-Ji-Er-Kang formula on Ang II-induced HUVECs injury, L-NAME-induced hypertension and cardiovascular remodeling in mice.	Polysaccharides	26-40	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	80-86
31196042-9	2019	CONCLUSION: Polysaccharide from XJEK exerts protective effects against Ang II-induced injury in HUVECs and L-NAME-induced hypertension in mice and the underlying mechanism may be attributed to improving endothelial dysfunction, OS and the inflammation status in mice.	Polysaccharides	12-26	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	71-77
31275257-4	2019	In this study, we used functional metagenomics to identify new metabolic pathways in uncultured bacteria involved in harvesting mucin glycans.	Polysaccharides	134-141	LOC100508689	Homo sapiens	128-133
31070896-2	2019	In this study, we report a series of cationic peptidopolysaccharides synthesized by thiol-ene click chemistry of grafting antimicrobial polypeptides, methacrylate-ended poly(lysine- random-phenylalanine) (Me-K nF m), onto a thiolated polysaccharide (dextran, Dex) backbone.	Polysaccharides	53-67	neurofilament, medium polypeptide	Mus musculus	210-214
30879681-3	2019	Three polysaccharides were shown to have the same chemical structure of beta-(1,3)-glucan with beta-(1,6) branches, and exhibited S-180 tumor-suppressing ability with good safety.	Polysaccharides	6-21	hemoglobin, beta adult major chain	Mus musculus	95-104
31079452-4	2019	Using the AXL receptor tyrosine kinase (AXL) as a model glycoprotein with multiple N-glycosylation sites, we show that those LCMS features that could be grouped into graph networks on the basis of glycan mass and retention time differences were actually N-glycopeptides with the same peptide backbone but different N-glycan compositions.	Polysaccharides	197-203	AXL receptor tyrosine kinase	Homo sapiens	10-13
31079452-4	2019	Using the AXL receptor tyrosine kinase (AXL) as a model glycoprotein with multiple N-glycosylation sites, we show that those LCMS features that could be grouped into graph networks on the basis of glycan mass and retention time differences were actually N-glycopeptides with the same peptide backbone but different N-glycan compositions.	Polysaccharides	197-203	AXL receptor tyrosine kinase	Homo sapiens	40-43
31258789-9	2019	Based on the significant glycomics profile, a glyco-model composed of five glycan peaks (GP6, GP9, GP11, GP21 and GP23) was established with area under the receiver operating characteristic curve (AUC) value of 0.80 (training cohort) and 0.77 (validation cohort), which showed good potential in discriminating peritoneal metastasis from advanced gastric cancer.	Polysaccharides	75-81	glycoprotein VI platelet	Homo sapiens	89-92
31258789-9	2019	Based on the significant glycomics profile, a glyco-model composed of five glycan peaks (GP6, GP9, GP11, GP21 and GP23) was established with area under the receiver operating characteristic curve (AUC) value of 0.80 (training cohort) and 0.77 (validation cohort), which showed good potential in discriminating peritoneal metastasis from advanced gastric cancer.	Polysaccharides	75-81	glycoprotein IX platelet	Homo sapiens	94-97
31258789-9	2019	Based on the significant glycomics profile, a glyco-model composed of five glycan peaks (GP6, GP9, GP11, GP21 and GP23) was established with area under the receiver operating characteristic curve (AUC) value of 0.80 (training cohort) and 0.77 (validation cohort), which showed good potential in discriminating peritoneal metastasis from advanced gastric cancer.	Polysaccharides	75-81	S100 calcium binding protein A10	Homo sapiens	99-103
30879666-1	2019	An active polysaccharide (LPD2) was isolated from longan pulp by comparing the effects of polysaccharides on the phagocytosis of macrophages.	Polysaccharides	10-24	neuroguidin	Homo sapiens	26-30
30879666-1	2019	An active polysaccharide (LPD2) was isolated from longan pulp by comparing the effects of polysaccharides on the phagocytosis of macrophages.	Polysaccharides	90-105	neuroguidin	Homo sapiens	26-30
31217790-0	2019	A novel polysaccharide from Lentinus edodes mycelia protects MIN6 cells against high glucose-induced damage via the MAPKs and Nrf2 pathways.	Polysaccharides	8-22	nuclear factor, erythroid derived 2, like 2	Mus musculus	126-130
31113887-0	2019	A glycan shield on chimpanzee CD4 protects against infection by primate lentiviruses (HIV/SIV).	Polysaccharides	2-8	CD4 molecule	Pan troglodytes	30-33
31113887-8	2019	Full restoration of virus infection in cells bearing chimpanzee CD4 requires reversion of both threonines at sites 34 and 68, destroying both of the glycosylation sites, suggesting that the effects of the glycans are additive.	Polysaccharides	205-212	CD4 molecule	Pan troglodytes	64-67
31113887-9	2019	Differentially glycosylated CD4 receptors were biochemically purified and used in neutralization assays and microscale thermophoresis to show that the glycans on chimpanzee CD4 reduce binding affinity with the lentiviral surface glycoprotein, Env.	Polysaccharides	151-158	CD4 molecule	Pan troglodytes	28-31
31113887-9	2019	Differentially glycosylated CD4 receptors were biochemically purified and used in neutralization assays and microscale thermophoresis to show that the glycans on chimpanzee CD4 reduce binding affinity with the lentiviral surface glycoprotein, Env.	Polysaccharides	151-158	CD4 molecule	Pan troglodytes	173-176
31113887-9	2019	Differentially glycosylated CD4 receptors were biochemically purified and used in neutralization assays and microscale thermophoresis to show that the glycans on chimpanzee CD4 reduce binding affinity with the lentiviral surface glycoprotein, Env.	Polysaccharides	151-158	syncytin-1	Pan troglodytes	243-246
31113887-10	2019	These glycans create a shield that protects CD4 from being engaged by viruses, demonstrating a powerful form of host resistance against deadly primate lentiviruses.	Polysaccharides	6-13	CD4 molecule	Pan troglodytes	44-47
31168439-8	2019	The secretory expression of the AST IV variant L89M/E90Q with higher catalytic efficiency should facilitate the studies on biosynthesis of sulfated polysaccharides.	Polysaccharides	148-163	sulfotransferase family 1A member 1	Rattus norvegicus	32-38
30904681-9	2019	Our method allows a fast determination of genetic variants and glycan compositions of human B2GP1 to be potentially used as diagnostic marker.	Polysaccharides	63-69	apolipoprotein H	Homo sapiens	92-97
30879680-1	2019	One water-soluble polysaccharide (AAP), with a molecular weight of 6.3 x 104 Da, was isolated from Artemisia annua L. Structrual analysis indicated that AAP was found to be a 1, 3-alpha-linked and 1, 3, 6-alpha-linked Glcp backbone, with a branch of 1, 6-alpha-linked Glcp and terminal 1-linked-L-Rhap along the main chain in a ratio of 1: 1: 1: 1.	Polysaccharides	18-32	serpin family F member 2	Homo sapiens	34-37
30879680-1	2019	One water-soluble polysaccharide (AAP), with a molecular weight of 6.3 x 104 Da, was isolated from Artemisia annua L. Structrual analysis indicated that AAP was found to be a 1, 3-alpha-linked and 1, 3, 6-alpha-linked Glcp backbone, with a branch of 1, 6-alpha-linked Glcp and terminal 1-linked-L-Rhap along the main chain in a ratio of 1: 1: 1: 1.	Polysaccharides	18-32	serpin family F member 2	Homo sapiens	153-156
30879693-1	2019	In this study, water-soluble polysaccharide from Arctium lappa was extracted, isolated and purified to be a fraction (ALP-1).	Polysaccharides	29-43	apolipoprotein A-I	Mus musculus	118-123
30903104-3	2019	Glycans attached to the death receptors such as CD95 and TRAIL-Rs, either alone or in a complex with galectins, might promote or inhibit apoptotic signals.	Polysaccharides	0-7	TNF superfamily member 10	Homo sapiens	57-62
31059977-0	2019	A unique polysaccharide from Hericium erinaceus mycelium ameliorates acetic acid-induced ulcerative colitis rats by modulating the composition of the gut microbiota, short chain fatty acids levels and GPR41/43 respectors.	Polysaccharides	9-23	free fatty acid receptor 3	Rattus norvegicus	201-206
31100702-10	2019	Recovery of the glycans from lactoferrin was, however, much lower when utilizing acetone precipitation versus the polystyrene resin; 52% versus 85% respectively.	Polysaccharides	16-23	lactotransferrin	Bos taurus	29-40
31100702-12	2019	A loss of glycans of lesser complexity (oligomannose and biantennary structures) was also observed for other glycoproteins (RNase B, porcine thyroglobulin, human lactoferrin).	Polysaccharides	10-17	lactotransferrin	Bos taurus	162-173
30794901-2	2019	In this study, two kinds of homogeneous polysaccharides namely ASe-TPS2 and NSe-TPS2 were obtained from artificial and natural Se-enriched teas with the molecular weights of 6.73 x 103 Da and 2.44 x 105 Da.	Polysaccharides	40-55	arylsulfatase L	Homo sapiens	63-66
30794901-2	2019	In this study, two kinds of homogeneous polysaccharides namely ASe-TPS2 and NSe-TPS2 were obtained from artificial and natural Se-enriched teas with the molecular weights of 6.73 x 103 Da and 2.44 x 105 Da.	Polysaccharides	40-55	tryptase beta 2	Homo sapiens	67-71
30794901-4	2019	It showed that ASe-TPS2 and NSe-TPS2 were acidic polysaccharides containing high amount of uronic acid.	Polysaccharides	49-64	arylsulfatase L	Homo sapiens	15-18
30794901-4	2019	It showed that ASe-TPS2 and NSe-TPS2 were acidic polysaccharides containing high amount of uronic acid.	Polysaccharides	49-64	tryptase beta 2	Homo sapiens	19-23
30794901-4	2019	It showed that ASe-TPS2 and NSe-TPS2 were acidic polysaccharides containing high amount of uronic acid.	Polysaccharides	49-64	enolase 2	Homo sapiens	28-31
30794901-4	2019	It showed that ASe-TPS2 and NSe-TPS2 were acidic polysaccharides containing high amount of uronic acid.	Polysaccharides	49-64	tryptase beta 2	Homo sapiens	32-36
30926436-1	2019	An immunologically active polysaccharide named as UPP-2 (1035.52 kDa) was isolated from Undaria pinnatifida using traditional water extraction followed by DEAE Sepharose fast flow chromatography.	Polysaccharides	26-40	uridine phosphorylase 2	Mus musculus	50-55
30926436-2	2019	UPP-2 was proven to be a low sulfated polysaccharide with relatively abundant uronic acid (13.08 +- 0.67%).	Polysaccharides	38-52	uridine phosphorylase 2	Mus musculus	0-5
30802520-0	2019	Structure of the capsular polysaccharide of the KPC-2-producing Klebsiella pneumoniae strain KK207-2 and assignment of the glycosyltransferases functions.	Polysaccharides	26-40	carbapenem-hydrolyzing beta-lactamase KPC-2	Klebsiella pneumoniae	48-53
31059977-4	2019	EP-1, a purified unique polysaccharide isolated from HE mycelium, has recently been identified as the active component responsible for anti- ulcerative colitis activity by using a cell model for identification.	Polysaccharides	24-38	prostaglandin E receptor 1	Rattus norvegicus	0-4
31142836-4	2019	RC1 conceals non-conserved immunodominant regions by the addition of glycans and/or multimerization on virus-like particles.	Polysaccharides	69-76	chromobox 8	Homo sapiens	0-3
31160781-6	2019	We also show that two anti-CD98 antibodies recognize distinct, multiple epitopes on CD98hc but not its glycans, explaining their robust reactivities.	Polysaccharides	103-110	solute carrier family 3 member 2	Homo sapiens	27-31
31142836-5	2019	Immunization of mice, rabbits and rhesus macaques with RC1 elicited serological responses that targeted the V3-glycan patch.	Polysaccharides	111-117	chromobox 8	Homo sapiens	55-58
31142836-6	2019	Antibody cloning and cryo-electron microscopy structures of antibody-envelope complexes confirmed that immunization with RC1 expands clones of B cells that carry the anti-V3-glycan patch antibodies, which resemble precursors of human broadly neutralizing antibodies.	Polysaccharides	174-180	chromobox 8	Homo sapiens	121-124
30901666-0	2019	Astragalus polysaccharides alleviate tilmicosin-induced toxicity in rats by inhibiting oxidative damage and modulating the expressions of HSP70, NF-kB and Nrf2/HO-1 pathway.	Polysaccharides	11-26	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	138-143
30901666-0	2019	Astragalus polysaccharides alleviate tilmicosin-induced toxicity in rats by inhibiting oxidative damage and modulating the expressions of HSP70, NF-kB and Nrf2/HO-1 pathway.	Polysaccharides	11-26	nuclear factor kappa B subunit 1	Rattus norvegicus	145-150
30901666-0	2019	Astragalus polysaccharides alleviate tilmicosin-induced toxicity in rats by inhibiting oxidative damage and modulating the expressions of HSP70, NF-kB and Nrf2/HO-1 pathway.	Polysaccharides	11-26	NFE2 like bZIP transcription factor 2	Rattus norvegicus	155-159
30901666-0	2019	Astragalus polysaccharides alleviate tilmicosin-induced toxicity in rats by inhibiting oxidative damage and modulating the expressions of HSP70, NF-kB and Nrf2/HO-1 pathway.	Polysaccharides	11-26	heme oxygenase 1	Rattus norvegicus	160-164
31214595-3	2019	This review details the general outlines for the production of FOS and GOS, both by enzymatic synthesis using disaccharides or other substrates, and by hydrolysis of polysaccharides.	Polysaccharides	166-181	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-66
31214162-11	2019	We confirmed a glycan-dependent binding of hemocyanins to chimeric TLR4 in vitro.	Polysaccharides	15-21	toll-like receptor 4	Mus musculus	67-71
31028779-6	2019	Effective HIV-1 immunogens are therefore likely to involve some degree of mimicry of both the protein and glycan components of Env.	Polysaccharides	106-112	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	127-130
31028779-7	2019	As such, considerable efforts have been made to characterize the structure of the envelope spike and its glycan shield.	Polysaccharides	105-111	endogenous retrovirus group K member 20	Homo sapiens	82-96
31028779-8	2019	This review summarizes the recent progress made in this field, with an emphasis on our growing understanding of the factors shaping the glycan shield of Env derived from both virus and soluble immunogens.	Polysaccharides	136-142	endogenous retrovirus group K member 20	Homo sapiens	153-156
31028779-9	2019	We argue that recombinant mimics of the envelope spike are currently capable of capturing many features of the native viral glycan shield.	Polysaccharides	124-130	endogenous retrovirus group K member 20	Homo sapiens	40-54
31133022-2	2019	METHODS: Superresolution microscopy, crystallographic structural analysis, glycan chip assay, SPR experiments, FACS assays, computational studies and mass spectrometric analysis firmly establish the mode of action of LIP, which involves dual selective recognition and efficient binding.	Polysaccharides	75-81	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	217-220
31050437-5	2019	The effect of CPA conjugation on an anticoagulant polysaccharide coating is also investigated.	Polysaccharides	50-64	carboxypeptidase A1	Homo sapiens	14-17
31050437-6	2019	The use of CPA instead of DA to make polysaccharide coating materials improves the coating rate, while maintaining excellent antiplatelet performance on the coated surface.	Polysaccharides	37-51	carboxypeptidase A1	Homo sapiens	11-14
31147550-2	2019	Using biochemical fractionation and two-dimensional HPLC, we identify an abundant and bioactive free glycan, the Manbeta1-4GlcNAc disaccharide in TREX1-associated autoimmune diseases.	Polysaccharides	101-107	three prime repair exonuclease 1	Homo sapiens	146-151
31137782-0	2019	Astragalus Polysaccharide RAP Induces Macrophage Phenotype Polarization to M1 via the Notch Signaling Pathway.	Polysaccharides	11-25	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	26-29
31117955-8	2019	The most significant SNPs were associated with B3GNT5, a gene encoding a glycosyltransferase involved in glycan synthesis.	Polysaccharides	105-111	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	Bos taurus	47-53
31137782-3	2019	Our previous study showed that a polysaccharide isolated from Radix Astragali, named RAP, was itself non-cytotoxic but induced RAW264.7 cells" cytotoxicity against cancer cells.	Polysaccharides	33-47	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	85-88
31137782-9	2019	These results suggested that Astragalus polysaccharide RAP induces macrophage"s polarization to M1 phenotype via the Notch signaling pathway.	Polysaccharides	40-54	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	55-58
31049543-1	2019	This study aimed at investigating the structure, hypoglycemic activity and the underlying mechanism of a homogeneous polysaccharide (PSP-2) purified from Sargassum pallidum.	Polysaccharides	117-131	regenerating family member 1 beta	Homo sapiens	133-138
31070650-0	2019	Total polysaccharides of adlay bran (Coix lachryma-jobi L.) improve TNF-alpha induced epithelial barrier dysfunction in Caco-2 cells via inhibition of the inflammatory response.	Polysaccharides	6-21	tumor necrosis factor	Homo sapiens	68-77
31049523-4	2019	Natural polysaccharides reduce triglyceride levels through ATGL-(PPAR-alpha)/(PGC-1alpha), (SREBP-1c)-ACC/FAS and ACC-CPT1 signal pathways, and exert cholesterol lowering effects via (SREBP-2)-HMGCR and bile acid biosynthesis pathways.	Polysaccharides	8-23	patatin like phospholipase domain containing 2	Homo sapiens	59-63
31058489-3	2019	Here, we describe the development of a novel and high-throughput-compatible workflow for the analysis of GSL-derived glycans based on ceramide glycanase digestion, 8-aminopyrene-1,3,6-trisulfonic acid (APTS) labeling, and multiplexed capillary gel electrophoresis coupled to laser-induced fluorescence detection (xCGE-LIF).	Polysaccharides	117-124	cathepsin A	Homo sapiens	105-108
31049523-4	2019	Natural polysaccharides reduce triglyceride levels through ATGL-(PPAR-alpha)/(PGC-1alpha), (SREBP-1c)-ACC/FAS and ACC-CPT1 signal pathways, and exert cholesterol lowering effects via (SREBP-2)-HMGCR and bile acid biosynthesis pathways.	Polysaccharides	8-23	peroxisome proliferator activated receptor alpha	Homo sapiens	65-75
31049523-4	2019	Natural polysaccharides reduce triglyceride levels through ATGL-(PPAR-alpha)/(PGC-1alpha), (SREBP-1c)-ACC/FAS and ACC-CPT1 signal pathways, and exert cholesterol lowering effects via (SREBP-2)-HMGCR and bile acid biosynthesis pathways.	Polysaccharides	8-23	PPARG coactivator 1 alpha	Homo sapiens	78-88
31049523-4	2019	Natural polysaccharides reduce triglyceride levels through ATGL-(PPAR-alpha)/(PGC-1alpha), (SREBP-1c)-ACC/FAS and ACC-CPT1 signal pathways, and exert cholesterol lowering effects via (SREBP-2)-HMGCR and bile acid biosynthesis pathways.	Polysaccharides	8-23	sterol regulatory element binding transcription factor 1	Homo sapiens	92-100
31049523-4	2019	Natural polysaccharides reduce triglyceride levels through ATGL-(PPAR-alpha)/(PGC-1alpha), (SREBP-1c)-ACC/FAS and ACC-CPT1 signal pathways, and exert cholesterol lowering effects via (SREBP-2)-HMGCR and bile acid biosynthesis pathways.	Polysaccharides	8-23	carnitine palmitoyltransferase 1A	Homo sapiens	118-122
31049523-4	2019	Natural polysaccharides reduce triglyceride levels through ATGL-(PPAR-alpha)/(PGC-1alpha), (SREBP-1c)-ACC/FAS and ACC-CPT1 signal pathways, and exert cholesterol lowering effects via (SREBP-2)-HMGCR and bile acid biosynthesis pathways.	Polysaccharides	8-23	sterol regulatory element binding transcription factor 2	Homo sapiens	184-191
31049523-4	2019	Natural polysaccharides reduce triglyceride levels through ATGL-(PPAR-alpha)/(PGC-1alpha), (SREBP-1c)-ACC/FAS and ACC-CPT1 signal pathways, and exert cholesterol lowering effects via (SREBP-2)-HMGCR and bile acid biosynthesis pathways.	Polysaccharides	8-23	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	193-198
31070650-2	2019	The present research was carried out to investigate the protective effect of total polysaccharides of adlay bran (TPA) on TNF-alpha-evoked epithelial barrier dysfunction in Caco-2 cells.	Polysaccharides	83-98	tumor necrosis factor	Homo sapiens	122-131
31058489-3	2019	Here, we describe the development of a novel and high-throughput-compatible workflow for the analysis of GSL-derived glycans based on ceramide glycanase digestion, 8-aminopyrene-1,3,6-trisulfonic acid (APTS) labeling, and multiplexed capillary gel electrophoresis coupled to laser-induced fluorescence detection (xCGE-LIF).	Polysaccharides	117-124	LIF interleukin 6 family cytokine	Homo sapiens	318-321
30776439-3	2019	By flow cytometry and ELISA analysis, sulfated polysaccharide SFMP-1 showed the best protective effect in reducing PM2.5-induced cell death, cell apoptosis and production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), which was accompanied by a diminished level in reactive oxygen species (ROS) formation caused by PM2.5 in rat alveolar macrophage NR8383 cells.	Polysaccharides	47-61	tumor necrosis factor	Rattus norvegicus	174-201
30938513-2	2019	Although various endo-beta- N-acetylglucosaminidase mutants have been developed for glycan remodeling, a side reaction has been reported between glycan oxazoline and amino groups.	Polysaccharides	84-90	O-GlcNAcase	Homo sapiens	22-51
30742920-8	2019	The sulfated polysaccharide (5 mug/mL) significantly suppressed the mRNA and protein expression of toll-like receptor-4 (TLR-4), myeloid differentiation factor (MyD88) and tumor necrosis factor receptor-associated factor-6 (TRAF-6) in LPS-stimulated THP-1 cells.	Polysaccharides	13-27	toll like receptor 4	Homo sapiens	99-119
30742920-8	2019	The sulfated polysaccharide (5 mug/mL) significantly suppressed the mRNA and protein expression of toll-like receptor-4 (TLR-4), myeloid differentiation factor (MyD88) and tumor necrosis factor receptor-associated factor-6 (TRAF-6) in LPS-stimulated THP-1 cells.	Polysaccharides	13-27	toll like receptor 4	Homo sapiens	121-126
31108940-0	2019	Polysaccharide from Okra (Abelmoschus esculentus (L.) Moench) Improves Antioxidant Capacity via PI3K/AKT Pathways and Nrf2 Translocation in a Type 2 Diabetes Model.	Polysaccharides	0-14	thymoma viral proto-oncogene 1	Mus musculus	101-104
31108940-0	2019	Polysaccharide from Okra (Abelmoschus esculentus (L.) Moench) Improves Antioxidant Capacity via PI3K/AKT Pathways and Nrf2 Translocation in a Type 2 Diabetes Model.	Polysaccharides	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	118-122
31108940-10	2019	Taken together, these findings suggest that a polysaccharide isolated from okra exerts anti-T2DM effects partly by modulating oxidative stress through PI3K/AKT/GSK3beta pathway-medicated Nrf2 transport.	Polysaccharides	46-60	thymoma viral proto-oncogene 1	Mus musculus	156-159
31108940-10	2019	Taken together, these findings suggest that a polysaccharide isolated from okra exerts anti-T2DM effects partly by modulating oxidative stress through PI3K/AKT/GSK3beta pathway-medicated Nrf2 transport.	Polysaccharides	46-60	glycogen synthase kinase 3 alpha	Mus musculus	160-168
31108940-10	2019	Taken together, these findings suggest that a polysaccharide isolated from okra exerts anti-T2DM effects partly by modulating oxidative stress through PI3K/AKT/GSK3beta pathway-medicated Nrf2 transport.	Polysaccharides	46-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	187-191
30742920-8	2019	The sulfated polysaccharide (5 mug/mL) significantly suppressed the mRNA and protein expression of toll-like receptor-4 (TLR-4), myeloid differentiation factor (MyD88) and tumor necrosis factor receptor-associated factor-6 (TRAF-6) in LPS-stimulated THP-1 cells.	Polysaccharides	13-27	MYD88 innate immune signal transduction adaptor	Homo sapiens	161-166
30742920-8	2019	The sulfated polysaccharide (5 mug/mL) significantly suppressed the mRNA and protein expression of toll-like receptor-4 (TLR-4), myeloid differentiation factor (MyD88) and tumor necrosis factor receptor-associated factor-6 (TRAF-6) in LPS-stimulated THP-1 cells.	Polysaccharides	13-27	TNF receptor associated factor 6	Homo sapiens	172-222
30742920-8	2019	The sulfated polysaccharide (5 mug/mL) significantly suppressed the mRNA and protein expression of toll-like receptor-4 (TLR-4), myeloid differentiation factor (MyD88) and tumor necrosis factor receptor-associated factor-6 (TRAF-6) in LPS-stimulated THP-1 cells.	Polysaccharides	13-27	TNF receptor associated factor 6	Homo sapiens	224-230
30742920-9	2019	These results showed the sulfated polysaccharide not only provided a good protection against LPS-induced cell toxicity, but also exerted an anti-inflammatory effect via the TLR4 signaling pathway.	Polysaccharides	34-48	toll like receptor 4	Homo sapiens	173-177
30776439-3	2019	By flow cytometry and ELISA analysis, sulfated polysaccharide SFMP-1 showed the best protective effect in reducing PM2.5-induced cell death, cell apoptosis and production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), which was accompanied by a diminished level in reactive oxygen species (ROS) formation caused by PM2.5 in rat alveolar macrophage NR8383 cells.	Polysaccharides	47-61	tumor necrosis factor	Rattus norvegicus	203-212
30776439-3	2019	By flow cytometry and ELISA analysis, sulfated polysaccharide SFMP-1 showed the best protective effect in reducing PM2.5-induced cell death, cell apoptosis and production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), which was accompanied by a diminished level in reactive oxygen species (ROS) formation caused by PM2.5 in rat alveolar macrophage NR8383 cells.	Polysaccharides	47-61	interleukin 1 beta	Rattus norvegicus	218-236
30776439-3	2019	By flow cytometry and ELISA analysis, sulfated polysaccharide SFMP-1 showed the best protective effect in reducing PM2.5-induced cell death, cell apoptosis and production of tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), which was accompanied by a diminished level in reactive oxygen species (ROS) formation caused by PM2.5 in rat alveolar macrophage NR8383 cells.	Polysaccharides	47-61	interleukin 1 beta	Rattus norvegicus	238-246
30735778-1	2019	A homogenous polysaccharide (DAP), with a molecular weight of 2.61 x 104 Da, was isolated from the roots of Dipsacus asper Wall.	Polysaccharides	13-27	death-associated protein	Rattus norvegicus	29-32
30472270-2	2019	We examined the structure and bioactivity of a new polysaccharide fraction purified from S. gracilis named SGP-1.	Polysaccharides	51-65	prosaposin	Rattus norvegicus	107-112
30832884-1	2019	Two polysaccharide fractions (TSP-1 and TSP-2) with molecular weights of 833.6 kDa and 81.6 kDa were isolated from Toona sinensis leaves (Meliaceae) by hot water extraction, DEAE Cellulose-52 chromatography and Sephacryl S-400 gel permeation chromatography.	Polysaccharides	4-18	tumor suppressor region 1	Mus musculus	30-35
30832884-1	2019	Two polysaccharide fractions (TSP-1 and TSP-2) with molecular weights of 833.6 kDa and 81.6 kDa were isolated from Toona sinensis leaves (Meliaceae) by hot water extraction, DEAE Cellulose-52 chromatography and Sephacryl S-400 gel permeation chromatography.	Polysaccharides	4-18	tumor suppressor region 2	Mus musculus	40-45
30852321-7	2019	Enzymatic removal of sialic acids results in the removal of galactose residues from the EPS upon subsequent treatment with beta-galactosidase, indicating a linkage between galactose and sialic acid at the terminus of glycan chains.	Polysaccharides	217-223	galactosidase beta 1	Homo sapiens	123-141
30712258-2	2019	Oral administration of this non-digestible complex polysaccharide caused a dectin-1-dependent immune response involving increased expression of interleukin-10 (IL-10), retinaldehyde dehydrogenase (Raldh) and pro-inflammatory cytokines in the gut mucosa.	Polysaccharides	51-65	C-type lectin domain family 7, member a	Mus musculus	75-83
31139190-4	2019	The N-terminal calcium-dependent (C-type) lectin domain of L-selectin interacts with numerous glycans, including sialyl Lewis X (sLex) for tethering/rolling and proteoglycans for TEM.	Polysaccharides	94-101	selectin L	Homo sapiens	59-69
31139190-7	2019	We will list some of the diverse glycans known to support L-selectin-dependent adhesion, within luminal and abluminal regions of the vessel wall.	Polysaccharides	33-40	selectin L	Homo sapiens	58-68
31073332-7	2019	Moreover, extracts from the double mutants had dramatically improved enzymatic polysaccharide hydrolysis efficiencies than the single mutants: 15.1% and 20.7% higher than ccoaomt1 and fpgs1, respectively.	Polysaccharides	79-93	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	171-179
31073332-7	2019	Moreover, extracts from the double mutants had dramatically improved enzymatic polysaccharide hydrolysis efficiencies than the single mutants: 15.1% and 20.7% higher than ccoaomt1 and fpgs1, respectively.	Polysaccharides	79-93	DHFS-FPGS homolog B	Arabidopsis thaliana	184-189
30844485-10	2019	Moreover, associations of monoclonal immunoglobulin (M-protein) and albumin levels with glycan traits were discovered in multiple myeloma patients.	Polysaccharides	88-94	myomesin 2	Homo sapiens	53-62
30824084-0	2019	Structural characterization, physicochemical properties and alpha-glucosidase inhibitory activity of polysaccharide from the fruits of wax apple.	Polysaccharides	101-115	alpha-glucosidase	Malus domestica	60-77
30776362-1	2019	BACKGROUND: Type II Congenital Disorders of Glycosylation (CDG-II) are a group of diseases with challenging diagnostics characterized by defects in the processing of glycans in the Golgi apparatus.	Polysaccharides	166-173	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	59-65
30776362-6	2019	CONCLUSIONS: Our methodology offers a feasible alternative to the current methods for CDG-II diagnosis by MS, which quantify glycan structures as fractions of the total summed signal across a mass spectrum, a strategy that lowers the variability of minor components.	Polysaccharides	125-131	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	86-92
30776362-7	2019	Moreover, given its sensitivity for less concentrated yet biologically relevant structures, it might assist the uncovering of novel diagnostic glycans in other CDG-II subtypes.	Polysaccharides	143-150	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	160-166
30712258-2	2019	Oral administration of this non-digestible complex polysaccharide caused a dectin-1-dependent immune response involving increased expression of interleukin-10 (IL-10), retinaldehyde dehydrogenase (Raldh) and pro-inflammatory cytokines in the gut mucosa.	Polysaccharides	51-65	interleukin 10	Mus musculus	144-158
30712258-2	2019	Oral administration of this non-digestible complex polysaccharide caused a dectin-1-dependent immune response involving increased expression of interleukin-10 (IL-10), retinaldehyde dehydrogenase (Raldh) and pro-inflammatory cytokines in the gut mucosa.	Polysaccharides	51-65	interleukin 10	Mus musculus	160-165
31048748-9	2019	This result is consistent with previous experimental studies regarding the glycan recognition of Abeta peptide.	Polysaccharides	75-81	amyloid beta precursor protein	Homo sapiens	97-102
30417320-9	2019	Accordingly, C. sorokiniana crude polysaccharides had a significant stimulatory effect on PAL activity with a percentage increase of 188.73% compared to the control.	Polysaccharides	34-49	phenylalanine ammonia-lyase	Solanum lycopersicum	90-93
30417320-12	2019	C. vulgaris and C. reinhardtii crude polysaccharides also exhibited higher APX and POD activity respectively.	Polysaccharides	37-52	cytosolic ascorbate peroxidase 2	Solanum lycopersicum	75-78
30748127-3	2019	Using a P factor of 235, 84.34% of the polysaccharides in 14.05 g L-1 of dissolved sugars could be obtained.	Polysaccharides	39-54	immunoglobulin kappa variable 1-16	Homo sapiens	66-69
30748127-5	2019	However, a maximum of 22.14 g L-1 of dissolved sugars was obtained with approximately 72.53% polysaccharides and Mw of 2,198 g mol-1 for a P factor of 601.	Polysaccharides	93-108	immunoglobulin kappa variable 1-16	Homo sapiens	30-33
30897013-1	2019	To examine the anti-metastatic activities of polysaccharides in broccoli, purified polysaccharides (BCE-I, -II, and -III) were isolated by fractionation of broccoli enzyme extracts and subsequent ethanol precipitation.	Polysaccharides	83-98	trefoil factor 1	Mus musculus	100-120
30892132-5	2019	The glycan modifications of PD-1 could be observed in three potential N-linked glycosylation sites, while no substantial influences were detected to the binding of toripalimab.	Polysaccharides	4-10	programmed cell death 1	Homo sapiens	28-32
31293748-4	2019	Here, we illustrate how automated glycan assembly (AGA) using a set of six monosaccharide building blocks provides quick access to a series of more than ten defined Lewis type-I and type-II antigens, including Lex, Ley, Lea, Leb and KH-1.	Polysaccharides	34-40	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	225-228
29362135-3	2019	The diversity of its functions are dependent on the binding of TSG-6 to numerous ligands, including matrix molecules such as glycosaminoglycans, as well as immune regulators and growth factors that themselves interact with these linear polysaccharides.	Polysaccharides	236-251	TNF alpha induced protein 6	Homo sapiens	63-68
31293748-4	2019	Here, we illustrate how automated glycan assembly (AGA) using a set of six monosaccharide building blocks provides quick access to a series of more than ten defined Lewis type-I and type-II antigens, including Lex, Ley, Lea, Leb and KH-1.	Polysaccharides	34-40	potassium voltage-gated channel modifier subfamily F member 1	Homo sapiens	233-237
31027312-2	2019	In this study, a homogeneous sulfated polysaccharide from the marine green alga Monostroma nitidum, designated MS-1, was isolated using water extraction and anion-exchange and size-exclusion chromatography.	Polysaccharides	38-52	actin-binding Rho activating protein	Rattus norvegicus	111-115
31025190-7	2019	We show that the glycans restrict the C-termini wagging motion into the solvent, limit their flexibility and keep them closer to the alpha-helical globule of hIFNgamma, thus possibly protecting them from proteolytic processing.	Polysaccharides	17-24	interferon gamma	Homo sapiens	158-167
30895774-0	2019	Colorimetric Detection of Salivary alpha-Amylase Using Maltose as a Noncompetitive Inhibitor for Polysaccharide Cleavage.	Polysaccharides	97-111	amylase alpha 1A	Homo sapiens	26-48
31068934-0	2019	Production of IgG2 Antibodies to Pneumococcal Polysaccharides After Vaccination of Treated HIV Patients May Be Augmented by IL-7Ralpha Signaling in ICOS+ Circulating T Follicular-Helper Cells.	Polysaccharides	46-61	interleukin 7 receptor	Homo sapiens	124-134
31068934-0	2019	Production of IgG2 Antibodies to Pneumococcal Polysaccharides After Vaccination of Treated HIV Patients May Be Augmented by IL-7Ralpha Signaling in ICOS+ Circulating T Follicular-Helper Cells.	Polysaccharides	46-61	inducible T cell costimulator	Homo sapiens	148-152
30835424-7	2019	We show that STALs that codisplay a high affinity CD22 glycan ligand and synthetic citrullinated antigen (CCP STALs) can prevent ACPA production from RA patients" memory B-cells in vitro.	Polysaccharides	55-61	CD22 molecule	Homo sapiens	50-54
31018591-6	2019	Consistent with the established binding of soluble heparin or HS to the Shh CW target motif, both polysaccharides impaired proteolytic Shh processing and release from source cells.	Polysaccharides	98-113	sonic hedgehog signaling molecule	Homo sapiens	72-75
31018591-6	2019	Consistent with the established binding of soluble heparin or HS to the Shh CW target motif, both polysaccharides impaired proteolytic Shh processing and release from source cells.	Polysaccharides	98-113	sonic hedgehog signaling molecule	Homo sapiens	135-138
30835424-7	2019	We show that STALs that codisplay a high affinity CD22 glycan ligand and synthetic citrullinated antigen (CCP STALs) can prevent ACPA production from RA patients" memory B-cells in vitro.	Polysaccharides	55-61	proteinase 3	Homo sapiens	129-133
30835424-9	2019	The results demonstrate that tolerization of the B-cells responsible for ACPA can be achieved by exploiting the inhibitory receptor CD22 with high-affinity glycan ligands.	Polysaccharides	156-162	proteinase 3	Homo sapiens	73-77
30835424-9	2019	The results demonstrate that tolerization of the B-cells responsible for ACPA can be achieved by exploiting the inhibitory receptor CD22 with high-affinity glycan ligands.	Polysaccharides	156-162	CD22 molecule	Homo sapiens	132-136
30882809-0	2019	Role of polysaccharide conjugation in physicochemical and emulsifying properties of egg phosvitin and the calcium binding capacity of its phosphopeptides.	Polysaccharides	8-22	casein kinase 2 beta	Homo sapiens	88-97
30732761-7	2019	Complementarily, the polysaccharides decreased AST, ALT, bilirubin, urea and creatinine serum levels, with consequent protection against tissue damage.	Polysaccharides	21-36	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	47-50
30732761-7	2019	Complementarily, the polysaccharides decreased AST, ALT, bilirubin, urea and creatinine serum levels, with consequent protection against tissue damage.	Polysaccharides	21-36	glutamic pyruvic transaminase, soluble	Mus musculus	52-55
30850477-9	2019	Interestingly, both IgE and IgG4 subsets have a 2-fold higher propensity to acquire Fab glycans compared with IgG1 or IgA.	Polysaccharides	88-95	immunoglobulin heavy constant epsilon	Homo sapiens	20-23
30658148-0	2019	Polysaccharides from chayote enhance lipid efflux and regulate NLRP3 inflammasome priming in macrophage-like THP-1 cells exposed to cholesterol crystals.	Polysaccharides	0-15	NLR family pyrin domain containing 3	Homo sapiens	63-68
30850477-9	2019	Interestingly, both IgE and IgG4 subsets have a 2-fold higher propensity to acquire Fab glycans compared with IgG1 or IgA.	Polysaccharides	88-95	FA complementation group B	Homo sapiens	84-87
30991766-4	2019	A water-soluble polysaccharide, PD1-1, was successfully obtained from dandelion through ultrasonic-assisted extraction and purification using diethylaminoethyl (DEAE)-Sepharose fast flow and Sephadex G-75 columns.	Polysaccharides	16-30	programmed cell death 1	Homo sapiens	32-37
30910957-4	2019	Here, we demonstrate that secreted protease of C1 esterase inhibitor (StcE), a bacterial protease from Escherichia coli, cleaves mucin domains by recognizing a discrete peptide- and glycan-based motif.	Polysaccharides	182-188	LOC100508689	Homo sapiens	129-134
30991766-5	2019	The results showed that PD1-1 is an inulin-type polysaccharide with a molecular weight of 2.6 kDa and is composed of glucose (52.39%), and mannose (45.41%).	Polysaccharides	48-62	programmed cell death 1	Homo sapiens	24-29
30816699-0	2019	Primary, Secondary, Tertiary and Quaternary Structure Levels in Linear Polysaccharides: From Random Coil, to Single Helix to Supramolecular Assembly.	Polysaccharides	71-86	coilin	Homo sapiens	100-104
30936310-0	2019	Correction for Bandala-Sanchez et al., CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function.	Polysaccharides	44-50	CD52 molecule	Homo sapiens	39-43
30959857-7	2019	Different polysaccharide-rich extracts showed the ability to inhibit pro-inflammatory enzymes (COX-1, COX-2, hyaluronidase), a radical scavenging effect (against DPPH  and ABTS +), and antiproliferative activity (in the A549 lung and SW480 colon cancer cell lines) in in vitro assays.	Polysaccharides	10-24	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	95-100
30936310-0	2019	Correction for Bandala-Sanchez et al., CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function.	Polysaccharides	44-50	high mobility group box 1	Homo sapiens	86-91
30959857-7	2019	Different polysaccharide-rich extracts showed the ability to inhibit pro-inflammatory enzymes (COX-1, COX-2, hyaluronidase), a radical scavenging effect (against DPPH  and ABTS +), and antiproliferative activity (in the A549 lung and SW480 colon cancer cell lines) in in vitro assays.	Polysaccharides	10-24	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-107
30221828-0	2019	Combining Butyrated ManNAc with Glycoengineered CHO Cells Improves EPO Glycan Quality and Production.	Polysaccharides	71-77	erythropoietin	Cricetulus griseus	67-70
30737276-3	2019	The structures of the four N-linked glycans from the PBCV-1 MCP consist of nonasaccharides, and similar glycans are not found elsewhere in the three domains of life.	Polysaccharides	36-43	Major capsid protein	Paramecium bursaria Chlorella virus 1	60-63
30770394-1	2019	Glycan determinants on von Willebrand factor (VWF) play critical roles in regulating its susceptibility to proteolysis and clearance.	Polysaccharides	0-6	von Willebrand factor	Homo sapiens	23-44
30770394-1	2019	Glycan determinants on von Willebrand factor (VWF) play critical roles in regulating its susceptibility to proteolysis and clearance.	Polysaccharides	0-6	von Willebrand factor	Homo sapiens	46-49
30770394-4	2019	To address this, we developed a novel lectin-binding panel to enable human VWF glycan characterization.	Polysaccharides	79-85	von Willebrand factor	Homo sapiens	75-78
30770394-5	2019	This methodology was then used to study glycan expression in a cohort of 110 patients with low VWF compared with O blood group-matched healthy controls.	Polysaccharides	40-46	von Willebrand factor	Homo sapiens	95-98
30770394-6	2019	Interestingly, significant interindividual heterogeneity in VWF glycan expression was seen in the healthy control population.	Polysaccharides	64-70	von Willebrand factor	Homo sapiens	60-63
30970514-0	2019	Immunomodulatory effects exerted by Poria Cocos polysaccharides via TLR4/TRAF6/NF-kappaB signaling in vitro and in vivo.	Polysaccharides	48-63	toll-like receptor 4	Mus musculus	68-72
30970514-0	2019	Immunomodulatory effects exerted by Poria Cocos polysaccharides via TLR4/TRAF6/NF-kappaB signaling in vitro and in vivo.	Polysaccharides	48-63	TNF receptor-associated factor 6	Mus musculus	73-78
30970514-0	2019	Immunomodulatory effects exerted by Poria Cocos polysaccharides via TLR4/TRAF6/NF-kappaB signaling in vitro and in vivo.	Polysaccharides	48-63	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	79-88
30952968-4	2019	Glycan microarray analysis showed an intriguing binding pattern where the antiserum showed near complete specificity for MUC4 TR glycopeptides and peptides, relative to all components on the array.	Polysaccharides	0-6	mucin-4	Oryctolagus cuniculus	121-125
30962950-0	2019	Core fucosylated glycan-dependent inhibitory effect of QSOX1-S on invasion and metastasis of hepatocellular carcinoma.	Polysaccharides	17-23	quiescin sulfhydryl oxidase 1	Homo sapiens	55-60
30962950-9	2019	Furthermore, overexpression of a mutant version of QSOX1-S, which had eliminated the core-fucosylated glycan at Asn-130, showed no demonstrable effect on invasion or metastasis of HCC cells.	Polysaccharides	102-108	quiescin sulfhydryl oxidase 1	Homo sapiens	51-56
30791981-7	2019	Interestingly, despite the critical role of the glycan-binding function of LMAN1 in its other known cargo clients, LMAN1 interacts with GABAARs in a glycan-independent manner.	Polysaccharides	48-54	lectin, mannose-binding, 1	Mus musculus	75-80
30791981-7	2019	Interestingly, despite the critical role of the glycan-binding function of LMAN1 in its other known cargo clients, LMAN1 interacts with GABAARs in a glycan-independent manner.	Polysaccharides	149-155	lectin, mannose-binding, 1	Mus musculus	115-120
30221828-8	2019	In summary, these results demonstrate 1,3,4-O-Bu3 ManNAc can compensate for the negative effect of NaBu on EPO glycan quality while simultaneously enhancing recombinant protein yields.	Polysaccharides	111-117	erythropoietin	Cricetulus griseus	107-110
30221828-2	2019	In this study, butyrate supplied by the precursor molecule 1,3,4-O-Bu3 ManNAc is applied to overcome the negative effects of NaBu on glycan quality while simultaneously increasing the productivity of the model recombinant erythropoietin (EPO).	Polysaccharides	133-139	erythropoietin	Cricetulus griseus	222-236
30221828-3	2019	The beneficial impact of 1,3,4-O-Bu3 ManNAc on EPO glycan quality, while evident in wild-type CHO cells, is particularly pronounced in glycoengineered CHO cells with stable overexpression of beta-1,4- and beta-1,6-N-acetylglucosaminyltransferases (GnTIV and GnTV) and alpha-2,6-sialyltransferase (ST6) enzymes responsible for N-glycan antennarity and sialylation.	Polysaccharides	51-57	erythropoietin	Cricetulus griseus	47-50
30221828-7	2019	Moreover, a detailed mass spectrometric ESI-LC-MS/MS characterization of glycans at each of the three N-glycosylation sites of EPO showed that the 1st N-site is highly sialylated and either the negative impact of NaBu or the beneficial effect 1,3,4-O-Bu3 ManNAc treatments mainly affects the 2nd and 3rd N-glycan sites of EPO protein.	Polysaccharides	73-80	erythropoietin	Cricetulus griseus	127-130
30586589-0	2019	Astragalus polysaccharide from Astragalus Melittin ameliorates inflammation via suppressing the activation of TLR-4/NF-kappaB p65 signal pathway and protects mice from CVB3-induced virus myocarditis.	Polysaccharides	11-25	toll-like receptor 4	Mus musculus	110-115
30552791-1	2019	beta-Mannosidase is a lysosomal enzyme from the glycosyl hydrolase family 2 that cleaves the single beta(1-4)-linked mannose at the nonreducing end of N-glycosylated proteins, and plays an important role in the polysaccharide degradation pathway.	Polysaccharides	211-225	mannosidase beta	Homo sapiens	0-16
30552791-1	2019	beta-Mannosidase is a lysosomal enzyme from the glycosyl hydrolase family 2 that cleaves the single beta(1-4)-linked mannose at the nonreducing end of N-glycosylated proteins, and plays an important role in the polysaccharide degradation pathway.	Polysaccharides	211-225	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	100-108
30597092-2	2019	SUMMARY ANSWER: GdA binds to blood CD16-CD56bright NK cells via its sialylated glycans and converts them to a dNK-like cells, which in turn regulate endothelial cell angiogenesis and trophoblast invasion via vascular endothelial growth factor (VEGF) and insulin-like growth factor-binding protein 1 (IGFBP-1) secretion, respectively.	Polysaccharides	79-86	progestagen associated endometrial protein	Homo sapiens	16-19
30597092-2	2019	SUMMARY ANSWER: GdA binds to blood CD16-CD56bright NK cells via its sialylated glycans and converts them to a dNK-like cells, which in turn regulate endothelial cell angiogenesis and trophoblast invasion via vascular endothelial growth factor (VEGF) and insulin-like growth factor-binding protein 1 (IGFBP-1) secretion, respectively.	Polysaccharides	79-86	Fc gamma receptor IIIa	Homo sapiens	35-39
30597240-2	2019	It was modified with chlorosulfonic acid-pyridine to obtain sulfated pumpkin polysaccharides (SP1, SP2) with different degrees of substitution, which was 0.35 and 0.65, respectively.	Polysaccharides	77-92	Sp2 transcription factor	Homo sapiens	99-102
30586589-0	2019	Astragalus polysaccharide from Astragalus Melittin ameliorates inflammation via suppressing the activation of TLR-4/NF-kappaB p65 signal pathway and protects mice from CVB3-induced virus myocarditis.	Polysaccharides	11-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	116-125
30586589-0	2019	Astragalus polysaccharide from Astragalus Melittin ameliorates inflammation via suppressing the activation of TLR-4/NF-kappaB p65 signal pathway and protects mice from CVB3-induced virus myocarditis.	Polysaccharides	11-25	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	126-129
30594614-5	2019	The results showed that the administration of yellow pear residue polysaccharides could markedly improve the immune organ index, carbon clearance ability and earlap swelling rate in immunosuppressed mice, significantly increased the secretion of TNF-alpha, INF-gamma, IL-4 and the activities of CAT, SOD, GSH-Px, and decreased MDA levels in liver, kidney and heart.	Polysaccharides	66-81	tumor necrosis factor	Mus musculus	246-255
30594614-5	2019	The results showed that the administration of yellow pear residue polysaccharides could markedly improve the immune organ index, carbon clearance ability and earlap swelling rate in immunosuppressed mice, significantly increased the secretion of TNF-alpha, INF-gamma, IL-4 and the activities of CAT, SOD, GSH-Px, and decreased MDA levels in liver, kidney and heart.	Polysaccharides	66-81	interleukin 4	Mus musculus	268-272
30742813-1	2019	About 15% of immunoglobulin G (IgG) molecules contain glycans linked to the antigen-binding fragments (Fab arms) in addition to the glycans linked to the crystallizable fragment (Fc tail) of all IgGs.	Polysaccharides	54-61	FA complementation group B	Homo sapiens	103-106
30742813-3	2019	The reliable generation of antibodies that either have or lack Fab glycans would be very helpful to study the role of Fab glycans in more detail.	Polysaccharides	67-74	FA complementation group B	Homo sapiens	63-66
30742813-3	2019	The reliable generation of antibodies that either have or lack Fab glycans would be very helpful to study the role of Fab glycans in more detail.	Polysaccharides	122-129	FA complementation group B	Homo sapiens	118-121
30742813-4	2019	In this study, we set out to remove Fab glycans by treating polyclonal and monoclonal human IgG antibodies with two commonly used glycosidases and an improved version of one of the two (Endo F3, PNGase F, and Rapid  PNGase F).	Polysaccharides	40-47	FA complementation group B	Homo sapiens	36-39
30742813-5	2019	Fc glycans can be removed using PNGase F and Rapid  PNGase F, but not with Endo F3.	Polysaccharides	3-10	N-glycanase 1	Homo sapiens	32-38
30742813-5	2019	Fc glycans can be removed using PNGase F and Rapid  PNGase F, but not with Endo F3.	Polysaccharides	3-10	N-glycanase 1	Homo sapiens	52-58
30742813-6	2019	For most antibody clones, Endo F3 partially cleaved off the Fab glycans.	Polysaccharides	64-71	FA complementation group B	Homo sapiens	60-63
30740857-3	2019	CLEC4M binds to mannose-containing glycans on FVIII.	Polysaccharides	35-42	C-type lectin domain family 4 member M	Homo sapiens	0-6
30740857-3	2019	CLEC4M binds to mannose-containing glycans on FVIII.	Polysaccharides	35-42	coagulation factor VIII	Homo sapiens	46-51
30740857-16	2019	Conclusions These findings suggest that CLEC4M is a novel clearance receptor that interacts with mannose-exposed glycans on FVIII in the presence or absence of VWF.	Polysaccharides	113-120	C-type lectin domain family 4 member M	Homo sapiens	40-46
30740857-16	2019	Conclusions These findings suggest that CLEC4M is a novel clearance receptor that interacts with mannose-exposed glycans on FVIII in the presence or absence of VWF.	Polysaccharides	113-120	coagulation factor VIII	Homo sapiens	124-129
30742813-7	2019	In contrast, PNGase F left the Fab glycans of most clones unaffected, but could remove glycans of some clones.	Polysaccharides	35-42	N-glycanase 1	Homo sapiens	13-19
30742813-7	2019	In contrast, PNGase F left the Fab glycans of most clones unaffected, but could remove glycans of some clones.	Polysaccharides	87-94	N-glycanase 1	Homo sapiens	13-19
30742813-9	2019	In summary, not all Fab glycans can be cleaved off by the tested glycosidases (under non-denaturing conditions), suggesting that Fab glycans are exposed to different degrees.	Polysaccharides	133-140	FA complementation group B	Homo sapiens	129-132
30839009-3	2019	A microfluidic chip featuring a HA x NA array was consequently developed herein for diagnosis and subtyping of InfA viruses via the use of glycan-coated magnetic beads followed by reverse transcription (RT) polymerase chain reaction (PCR).	Polysaccharides	139-145	neuraminidase 1	Homo sapiens	37-39
30641231-4	2019	Seven intact glycan isomers with alpha2-6 linked sialic acids, five of them also fucosylated, were the most meaningful to distinguish between PDAC and ChrP patients.	Polysaccharides	13-19	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	33-41
30471378-1	2019	ETHNOPHARMACOLOGICAL REVELVANCE: CGA consisting of Cordyceps sinensis mycelia polysaccharide, gypenosides and amygdalin, was demonstrated to be the effective components formula in Fuzheng Huayu (FZHY) capsule, a traditional Chinese medicine approved by China food and drug administration for treatment of liver fibrosis and to inhibit transforming growth factor-beta1 (TGF-beta1) signaling, previously.	Polysaccharides	78-92	chromogranin A	Rattus norvegicus	33-36
30537502-1	2019	A sulfated polysaccharide ascophyllan inhibited alpha-glucosidase in a concentration dependent manner, and &gt;90% activity was inhibited at 1.0 mg/mL.	Polysaccharides	11-25	sucrase-isomaltase	Homo sapiens	48-65
30553856-4	2019	The molecular weight of the polysaccharide fraction of ARP was calculated to be 1.23 x 104 Da from a calibration curve obtained with dextran standards.	Polysaccharides	28-42	arginine-glutamic acid dipeptide repeats	Homo sapiens	55-58
30553856-11	2019	The experiments of the effect of ARP on the activation of macrophage in vitro indicated that ARP significantly enhanced the production of TNF-alpha, IL-6 and IL-1beta which suggested the polysaccharide induced the functional activation of macrophage.	Polysaccharides	187-201	arginine-glutamic acid dipeptide repeats	Homo sapiens	33-36
30553856-11	2019	The experiments of the effect of ARP on the activation of macrophage in vitro indicated that ARP significantly enhanced the production of TNF-alpha, IL-6 and IL-1beta which suggested the polysaccharide induced the functional activation of macrophage.	Polysaccharides	187-201	arginine-glutamic acid dipeptide repeats	Homo sapiens	93-96
30529353-1	2019	Two homogeneous polysaccharide fractions named SCP-1 (7.16 x 106 Da) and SCP-2 (2.00 x 104 Da) were purified by DEAE-52 cellulose and Sephadex G-200 column chromatography successively from Camellia oleifera Abel seed cake.	Polysaccharides	16-30	stem cell proliferation 1	Mus musculus	47-52
30891034-0	2019	The Formation of Glycan-Specific Natural Antibodies Repertoire in GalT-KO Mice Is Determined by Gut Microbiota.	Polysaccharides	17-23	galactose-1-phosphate uridyl transferase	Mus musculus	66-70
30551085-3	2019	Results indicated that lysozyme boosted the ES hydrolysis significantly with approximately 236.5 mg/L soluble chemical oxygen demand (SCOD), 58.6 mg/L polysaccharide and 662.7 mg/L protein release within 240 min at the lysozyme dosage of 150 mg/gSS.	Polysaccharides	151-165	lysozyme	Homo sapiens	23-31
30551085-4	2019	Arising lysozyme dosages (from 0 to 150 mg/gSS step by step) could dramatically enhance the efficiency of the enzyme on ES with the concentration of polysaccharide increased from 84.6 mg/L to 143.2 mg/L and protein increased from 325.0 mg/L to 987.7 mg/L in total EPS.	Polysaccharides	149-163	lysozyme	Homo sapiens	8-16
30551085-4	2019	Arising lysozyme dosages (from 0 to 150 mg/gSS step by step) could dramatically enhance the efficiency of the enzyme on ES with the concentration of polysaccharide increased from 84.6 mg/L to 143.2 mg/L and protein increased from 325.0 mg/L to 987.7 mg/L in total EPS.	Polysaccharides	149-163	glutathione synthetase	Homo sapiens	43-46
30854233-1	2019	FUT1 and FUT2 encode alpha 1, 2-fucosyltransferases which catalyze the addition of alpha 1, 2-linked fucose to glycans.	Polysaccharides	111-118	fucosyltransferase 1	Mus musculus	0-4
30854233-1	2019	FUT1 and FUT2 encode alpha 1, 2-fucosyltransferases which catalyze the addition of alpha 1, 2-linked fucose to glycans.	Polysaccharides	111-118	fucosyltransferase 2	Mus musculus	9-13
30854233-2	2019	Glycan products of FUT1 and FUT2, such as Globo H and Lewis Y, are highly expressed on malignant tissues, including breast cancer.	Polysaccharides	0-6	fucosyltransferase 1	Mus musculus	19-23
30854233-2	2019	Glycan products of FUT1 and FUT2, such as Globo H and Lewis Y, are highly expressed on malignant tissues, including breast cancer.	Polysaccharides	0-6	fucosyltransferase 2	Mus musculus	28-32
30801078-2	2019	Herein, we reported a new type of targeted supramolecular nanoparticles for photodynamic therapy of tumor cells constructed using adamantane-functionalized transferrin protein (Ad-TRF) and a beta-cyclodextrin-functionalized ruthenium complex (Ru-HOP-CD), wherein Ad-TRFs acted as the targeted sites for tumor cells, the coordinated Ru(ii) centers acted as the PDT active sites, and the biocompatible polysaccharide beta-cyclodextrins acted as the non-covalent linkers.	Polysaccharides	400-414	transferrin	Homo sapiens	156-167
30891034-6	2019	Our data show that the orders clostridiales (most abundant), bacteriodales, lactobacillales, and deferribacterales may be associated with the development of the final repertoire of natural anti-glycan antibodies in GalT-KO mice.	Polysaccharides	194-200	galactose-1-phosphate uridyl transferase	Mus musculus	215-219
30600033-0	2019	Sulfated polysaccharide JCS1S2 inhibits angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling.	Polysaccharides	9-23	kinase insert domain receptor	Homo sapiens	67-73
30640124-0	2019	Focusing aptamer selection on the glycan structure of prostate-specific antigen: Toward more specific detection of prostate cancer.	Polysaccharides	34-40	kallikrein related peptidase 3	Homo sapiens	54-79
30640124-3	2019	In this work, we describe a simple method for directing the selection of aptamers toward the glycan structure of the glycoproteins, with prostate-specific antigen (PSA) as a model target.	Polysaccharides	93-99	kallikrein related peptidase 3	Homo sapiens	137-168
30640124-4	2019	Using this strategy, we identified one aptamer (PSA-1) that binds the glycan moiety of PSA with reasonable affinity (a dissociation constant of 177 +- 65 nM).	Polysaccharides	70-76	kallikrein related peptidase 3	Homo sapiens	48-51
30640124-4	2019	Using this strategy, we identified one aptamer (PSA-1) that binds the glycan moiety of PSA with reasonable affinity (a dissociation constant of 177 +- 65 nM).	Polysaccharides	70-76	kallikrein related peptidase 3	Homo sapiens	87-90
30640124-7	2019	Although validation on a larger cohort is needed, this is the first demonstration of an aptamer-based sensor to detect PSA by focusing in its glycan moiety.	Polysaccharides	142-148	kallikrein related peptidase 3	Homo sapiens	119-122
30714345-0	2019	Orally Delivered Antisense Oligodeoxyribonucleotides of TNF-alpha via Polysaccharide-Based Nanocomposites Targeting Intestinal Inflammation.	Polysaccharides	70-84	tumor necrosis factor	Homo sapiens	56-65
30600033-0	2019	Sulfated polysaccharide JCS1S2 inhibits angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling.	Polysaccharides	9-23	vascular endothelial growth factor A	Homo sapiens	67-71
30659446-4	2019	Heparin, a polysaccharide closely related to HS, also reduced the Hsp90-stimulated migration and invasion of cells.	Polysaccharides	11-25	heat shock protein 90 alpha family class A member 1	Homo sapiens	66-71
30600033-0	2019	Sulfated polysaccharide JCS1S2 inhibits angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling.	Polysaccharides	9-23	kinase insert domain receptor	Homo sapiens	92-98
30600033-0	2019	Sulfated polysaccharide JCS1S2 inhibits angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling.	Polysaccharides	9-23	mitogen-activated protein kinase 1	Homo sapiens	99-102
30600033-0	2019	Sulfated polysaccharide JCS1S2 inhibits angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling.	Polysaccharides	9-23	vascular endothelial growth factor A	Homo sapiens	74-78
31342012-4	2019	It was observed that alpha-GC-driven IgG1 class switch against a polysaccharide Ag was dependent on the NKTfh subset.	Polysaccharides	65-79	LOC105243590	Mus musculus	37-41
30422384-9	2019	Finally, we demonstrated that glycan-galectin-3 interactions reduced proMMP-9 activation.	Polysaccharides	30-36	galectin 3	Homo sapiens	37-47
30556937-8	2019	In general, the treatment of cariogenic biofilms with Rh2 significantly decreased biomass accumulation by inhibiting bacterial growth and extracellular polysaccharide synthesis without any cytotoxic effects.	Polysaccharides	152-166	Rh associated glycoprotein	Homo sapiens	54-57
30465847-6	2019	Structure analyses showed that LMP1 were homogalacturonans-enriched non-esterified polysaccharides.	Polysaccharides	83-98	PDZ and LIM domain 7	Homo sapiens	31-35
30520953-3	2019	Objective: To assess whether polysaccharide-based scaffold (PS) constructs that are cross-linked with smoothened agonist (SAG), vascular endothelial growth factor (VEGF), and bone morphogenetic protein 6 (BMP-6) would substantially increase bone regeneration.	Polysaccharides	29-43	vascular endothelial growth factor A	Rattus norvegicus	128-162
30393083-1	2019	Dendritic cell-associated C-type lectin-2 (i.e., dectin-2) recognizes fungal polysaccharides, including alpha-mannan.	Polysaccharides	77-92	C-type lectin domain family 4, member n	Mus musculus	0-41
30393083-1	2019	Dendritic cell-associated C-type lectin-2 (i.e., dectin-2) recognizes fungal polysaccharides, including alpha-mannan.	Polysaccharides	77-92	C-type lectin domain family 4, member n	Mus musculus	49-57
30582698-5	2019	Even though this glycan specificity of MGL is well described, there is a lack of understanding of the actual glycoproteins that bind MGL.	Polysaccharides	17-23	C-type lectin domain containing 10A	Homo sapiens	39-42
30649336-6	2019	J Biochem 2017;161:99-111) showed a specific glycosylation at a site proximal to the beta-secretase cleavage site and decreased productions of Abeta1-40 and Abeta1-42 in HEK293T cells transfected with a particular mucin-type glycan initiation enzyme, GalNAc-T6, indicating a novel pharmaceutical strategy to inhibit the production of Abeta through the upregulation of mucin-type O-glycosylation.	Polysaccharides	225-231	polypeptide N-acetylgalactosaminyltransferase 6	Homo sapiens	251-260
30989864-10	2019	01),and the model was relatively stable within 36 h. Mori Folium polysaccharides and flavonoids all alleviated insulin resistance,among which Mori Folium flavonoids had better effect in alleviating Hep G2 insulin resistance(P&lt;0.	Polysaccharides	65-80	insulin	Homo sapiens	111-118
30867744-4	2019	The glycans Lewis X (LeX), Sialyl lewis X (SLeX) and Sialyl Tn (STn) have previously been associated with aggressiveness, dissemination and poor prognosis in human bladder cancer, additionally N-glycolyl GM3 (NGcGM3) is a neo-antigen expressed in many types of tumors; however, to the best of our knowledge, its expression has not previously been assessed in this type of cancer.	Polysaccharides	4-11	fucosyltransferase 4	Homo sapiens	12-19
30867744-4	2019	The glycans Lewis X (LeX), Sialyl lewis X (SLeX) and Sialyl Tn (STn) have previously been associated with aggressiveness, dissemination and poor prognosis in human bladder cancer, additionally N-glycolyl GM3 (NGcGM3) is a neo-antigen expressed in many types of tumors; however, to the best of our knowledge, its expression has not previously been assessed in this type of cancer.	Polysaccharides	4-11	fucosyltransferase 4	Homo sapiens	21-24
30380399-5	2019	Mass spectrometry analysis focussed on the identification of proteins carrying glycans with immunomodulatory epitopes, including fibronectin, lactoferrin, clusterin, zinc-alpha2-glycoprotein, prostate acid phosphatase and prostate-specific antigen; these should be submitted to further detailed analysis.	Polysaccharides	79-86	fibronectin 1	Homo sapiens	129-140
30380399-5	2019	Mass spectrometry analysis focussed on the identification of proteins carrying glycans with immunomodulatory epitopes, including fibronectin, lactoferrin, clusterin, zinc-alpha2-glycoprotein, prostate acid phosphatase and prostate-specific antigen; these should be submitted to further detailed analysis.	Polysaccharides	79-86	kallikrein related peptidase 3	Homo sapiens	222-247
30989864-14	2019	Mori Folium polysaccharides and flavonoids can alleviate insulin resistance in Hep G2 cells,and its mechanism may be the alleviation of insulin resistance by inhibiting JNK signaling pathway.	Polysaccharides	12-27	insulin	Homo sapiens	57-64
30989864-14	2019	Mori Folium polysaccharides and flavonoids can alleviate insulin resistance in Hep G2 cells,and its mechanism may be the alleviation of insulin resistance by inhibiting JNK signaling pathway.	Polysaccharides	12-27	insulin	Homo sapiens	136-143
30989864-14	2019	Mori Folium polysaccharides and flavonoids can alleviate insulin resistance in Hep G2 cells,and its mechanism may be the alleviation of insulin resistance by inhibiting JNK signaling pathway.	Polysaccharides	12-27	mitogen-activated protein kinase 8	Homo sapiens	169-172
30818380-8	2019	Clinical remission was associated with complete glycan normalization for PR3-ANCA patients but not for MPO-ANCA patients.	Polysaccharides	48-54	proteinase 3	Homo sapiens	73-76
30818380-11	2019	CONCLUSIONS/SIGNIFICANCE: Significant differences exist between MPO and PR3-ANCA regarding the changes in amounts and types of glycans on Fc fragment and the association with disease activity.	Polysaccharides	127-134	myeloperoxidase	Homo sapiens	64-67
30818380-11	2019	CONCLUSIONS/SIGNIFICANCE: Significant differences exist between MPO and PR3-ANCA regarding the changes in amounts and types of glycans on Fc fragment and the association with disease activity.	Polysaccharides	127-134	proteinase 3	Homo sapiens	72-75
30989864-10	2019	01),and the model was relatively stable within 36 h. Mori Folium polysaccharides and flavonoids all alleviated insulin resistance,among which Mori Folium flavonoids had better effect in alleviating Hep G2 insulin resistance(P&lt;0.	Polysaccharides	65-80	insulin	Homo sapiens	205-212
30714735-1	2019	A polysaccharide, Ali-1, was isolated from the roots of Eurycoma longifolia, a popular traditional medicinal herb in Malaysia.	Polysaccharides	2-16	adhesion molecule with Ig like domain 2	Homo sapiens	18-23
30468716-1	2019	Sialic acids (Sia) are involved in various biological and pathological processes, and are often found attached to non-reducing ends of glycans through either alpha2,3- or alpha2,6-linkages.	Polysaccharides	135-142	immunoglobulin kappa variable 2-24	Homo sapiens	158-167
30718403-6	2019	In silico modeling and site-directed mutagenesis identified charged residues at the CD4-Env interface and clashes between CD4- and Env-encoded glycans as mechanisms of inhibition.	Polysaccharides	143-150	CD4 molecule	Pan troglodytes	84-87
30718403-6	2019	In silico modeling and site-directed mutagenesis identified charged residues at the CD4-Env interface and clashes between CD4- and Env-encoded glycans as mechanisms of inhibition.	Polysaccharides	143-150	syncytin-1	Pan troglodytes	88-91
30718403-6	2019	In silico modeling and site-directed mutagenesis identified charged residues at the CD4-Env interface and clashes between CD4- and Env-encoded glycans as mechanisms of inhibition.	Polysaccharides	143-150	CD4 molecule	Pan troglodytes	122-125
30718403-6	2019	In silico modeling and site-directed mutagenesis identified charged residues at the CD4-Env interface and clashes between CD4- and Env-encoded glycans as mechanisms of inhibition.	Polysaccharides	143-150	syncytin-1	Pan troglodytes	131-134
30718403-7	2019	CD4 polymorphisms also reduced Env-mediated cell entry of monkey SIVs, which was dependent on at least one D1 domain glycan.	Polysaccharides	117-123	CD4 molecule	Pan troglodytes	0-3
30718403-7	2019	CD4 polymorphisms also reduced Env-mediated cell entry of monkey SIVs, which was dependent on at least one D1 domain glycan.	Polysaccharides	117-123	syncytin-1	Pan troglodytes	31-34
30553376-7	2019	Our results also indicate that this polysaccharide activates RAW264.7 cells via MAPK and NF-kappaB signaling pathways and the Toll-like receptor 2(TLR2).	Polysaccharides	36-50	toll-like receptor 2	Mus musculus	126-146
30553376-7	2019	Our results also indicate that this polysaccharide activates RAW264.7 cells via MAPK and NF-kappaB signaling pathways and the Toll-like receptor 2(TLR2).	Polysaccharides	36-50	toll-like receptor 2	Mus musculus	147-151
30439422-0	2019	Polysaccharide from Phellinus Igniarius activates TLR4-mediated signaling pathways in macrophages and shows immune adjuvant activity in mice.	Polysaccharides	0-14	toll-like receptor 4	Mus musculus	50-54
30465838-1	2019	In this study, novel polysaccharides extracted from cuttlefish skin (CSP) and muscle (CMP), by precipitation with cetylpyridinium, were characterized and their antioxidant and antibacterial activities were investigated.	Polysaccharides	21-36	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	69-72
30781796-4	2019	Here, our results indicate the glycan moiety of Env as the responsible immune modulating activity.	Polysaccharides	31-37	melanoma antigen	Mus musculus	48-51
30465838-7	2019	Fractionation of cuttlefish polysaccharides, by DEAE-cellulose column showed one peak during the buffer elution phase and three major fractions for CMP and two peaks for CSP during the linear gradient of NaCl.	Polysaccharides	28-43	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	170-173
30563843-7	2019	Mutagenesis and kinetic analyses confirmed that renin-mediated production of angiotensin I is controlled by interactions of amino acid residues and glycan components outside renin"s active-site cleft.	Polysaccharides	148-154	renin	Homo sapiens	48-53
30563843-7	2019	Mutagenesis and kinetic analyses confirmed that renin-mediated production of angiotensin I is controlled by interactions of amino acid residues and glycan components outside renin"s active-site cleft.	Polysaccharides	148-154	angiotensinogen	Homo sapiens	77-90
30837888-5	2019	Two cytosolic F-box proteins, Fbs1 and Fbs2, recognize high-mannose glycans synthesized in the ER, and SCFFbs1 and SCFFbs2 ubiquitinate excess unassembled or misfolded glycoproteins in the ERAD pathway by recognizing the innermost glycans, which serve as signals for aberrant proteins.	Polysaccharides	68-75	F-box protein 2	Homo sapiens	30-34
30837888-5	2019	Two cytosolic F-box proteins, Fbs1 and Fbs2, recognize high-mannose glycans synthesized in the ER, and SCFFbs1 and SCFFbs2 ubiquitinate excess unassembled or misfolded glycoproteins in the ERAD pathway by recognizing the innermost glycans, which serve as signals for aberrant proteins.	Polysaccharides	68-75	F-box protein 6	Homo sapiens	39-43
30775162-11	2019	The stable cell lines expressing ST6Gal1 modify the glycans on the surface of the CHO cells as detected by fluorescently labelled lectin microscopy.	Polysaccharides	52-59	beta-galactoside alpha-2,6-sialyltransferase 1	Cricetulus griseus	33-40
30804792-0	2018	Astragalus Polysaccharide RAP Selectively Attenuates Paclitaxel-Induced Cytotoxicity Toward RAW 264.7 Cells by Reversing Cell Cycle Arrest and Apoptosis.	Polysaccharides	11-25	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	26-29
30737411-0	2019	Alkali treated antioxidative crude polysaccharide from Russula alatoreticula potentiates murine macrophages by tunning TLR/NF-kappaB pathway.	Polysaccharides	35-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	123-132
30804792-1	2018	Purpose: The purpose of this study was to determine if an Astragalus polysaccharide (RAP) can protect immune cells from the toxic side effects of paclitaxel (Taxol), a powerful anti-tumor drug whose equally powerful side effects limit its clinical use.	Polysaccharides	69-83	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	85-88
30737411-6	2019	Alongside, the polysaccharides effectively triggered transcriptional activation of Toll like receptor (TLR)-2, TLR-4, nuclear factor kappa B (NF-kappaB), cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-alpha, Ikappa-Balpha, interferon (IFN)-gamma and interleukin (IL)-10 genes explaining mode of action.	Polysaccharides	15-30	toll-like receptor 2	Mus musculus	83-109
30655174-4	2019	Here in this study, full-length hepatitis B core antigen virus-like particles (HBc VLPs) was used as a novel potential carrier protein for conjugation of meningococcal group C polysaccharides (CPS) with heterobifunctional polyethylene glycol (PEG) of different length (2, 5 and 10 kDa) as linkers.	Polysaccharides	176-191	keratin 88, pseudogene	Homo sapiens	79-82
30737411-6	2019	Alongside, the polysaccharides effectively triggered transcriptional activation of Toll like receptor (TLR)-2, TLR-4, nuclear factor kappa B (NF-kappaB), cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-alpha, Ikappa-Balpha, interferon (IFN)-gamma and interleukin (IL)-10 genes explaining mode of action.	Polysaccharides	15-30	toll-like receptor 4	Mus musculus	111-116
30655174-11	2019	All these results demonstrated that HBc VLPs can be used as potential carrier protein to develop polysaccharide conjugate vaccines effective in eliciting long-lasting and strong cellular immune response.	Polysaccharides	97-111	keratin 88, pseudogene	Homo sapiens	36-39
30737411-6	2019	Alongside, the polysaccharides effectively triggered transcriptional activation of Toll like receptor (TLR)-2, TLR-4, nuclear factor kappa B (NF-kappaB), cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-alpha, Ikappa-Balpha, interferon (IFN)-gamma and interleukin (IL)-10 genes explaining mode of action.	Polysaccharides	15-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	118-140
30737411-6	2019	Alongside, the polysaccharides effectively triggered transcriptional activation of Toll like receptor (TLR)-2, TLR-4, nuclear factor kappa B (NF-kappaB), cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-alpha, Ikappa-Balpha, interferon (IFN)-gamma and interleukin (IL)-10 genes explaining mode of action.	Polysaccharides	15-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
30737411-6	2019	Alongside, the polysaccharides effectively triggered transcriptional activation of Toll like receptor (TLR)-2, TLR-4, nuclear factor kappa B (NF-kappaB), cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-alpha, Ikappa-Balpha, interferon (IFN)-gamma and interleukin (IL)-10 genes explaining mode of action.	Polysaccharides	15-30	cytochrome c oxidase II, mitochondrial	Mus musculus	154-176
30737411-6	2019	Alongside, the polysaccharides effectively triggered transcriptional activation of Toll like receptor (TLR)-2, TLR-4, nuclear factor kappa B (NF-kappaB), cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-alpha, Ikappa-Balpha, interferon (IFN)-gamma and interleukin (IL)-10 genes explaining mode of action.	Polysaccharides	15-30	nitric oxide synthase 2, inducible	Mus musculus	178-209
30737411-6	2019	Alongside, the polysaccharides effectively triggered transcriptional activation of Toll like receptor (TLR)-2, TLR-4, nuclear factor kappa B (NF-kappaB), cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-alpha, Ikappa-Balpha, interferon (IFN)-gamma and interleukin (IL)-10 genes explaining mode of action.	Polysaccharides	15-30	nitric oxide synthase 2, inducible	Mus musculus	211-215
30737411-6	2019	Alongside, the polysaccharides effectively triggered transcriptional activation of Toll like receptor (TLR)-2, TLR-4, nuclear factor kappa B (NF-kappaB), cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-alpha, Ikappa-Balpha, interferon (IFN)-gamma and interleukin (IL)-10 genes explaining mode of action.	Polysaccharides	15-30	tumor necrosis factor	Mus musculus	218-251
30737411-6	2019	Alongside, the polysaccharides effectively triggered transcriptional activation of Toll like receptor (TLR)-2, TLR-4, nuclear factor kappa B (NF-kappaB), cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-alpha, Ikappa-Balpha, interferon (IFN)-gamma and interleukin (IL)-10 genes explaining mode of action.	Polysaccharides	15-30	interleukin 10	Mus musculus	295-314
30727738-0	2019	Direct immobilization of sugar probes on bovine serum albumin-coated gold substrate for the development of glycan biosensors.	Polysaccharides	107-113	albumin	Homo sapiens	48-61
30743988-0	2019	The beta-N-Acetylhexosaminidase in the Synthesis of Bioactive Glycans: Protein and Reaction Engineering.	Polysaccharides	62-69	O-GlcNAcase	Homo sapiens	4-31
30778346-3	2019	We have previously shown cell surface glycan modification by the circulating sialyltransferase ST6Gal-1 regulates de novo inflammatory cell production via a novel extrinsic glycosylation pathway.	Polysaccharides	38-44	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	95-103
30624066-4	2019	Finally, N-glycans, enzymatically released as free oligosaccharides from the GP, are screened against the GBP using ESI-MS to identify the glycans that are recognized by the GBP.	Polysaccharides	11-18	galectin 1	Homo sapiens	174-177
30328700-7	2019	We found that many of the sequences had conserved glycans at positions N160 (10/11) and N332 (9/11), which are known to be critical for the binding of PG9/PG16-like and PGT128-like bNAbs, respectively.	Polysaccharides	50-57	n332 (9/11	None	88-98
30328700-8	2019	We also observed conservation of critical glycans at positions N234 and N276 critical for the interaction with CD4 binding site bNAbs in 8/11 and 11/11 sequences, respectively.	Polysaccharides	42-49	CD4 molecule	Homo sapiens	111-114
30716533-0	2019	Epigenetic silencing of the synthesis of immunosuppressive Siglec ligand glycans by NF-kappaB/EZH2/YY1 axis in early-stage colon cancers.	Polysaccharides	73-80	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	94-98
30716533-0	2019	Epigenetic silencing of the synthesis of immunosuppressive Siglec ligand glycans by NF-kappaB/EZH2/YY1 axis in early-stage colon cancers.	Polysaccharides	73-80	YY1 transcription factor	Homo sapiens	99-102
30716533-2	2019	Expression of these normal glycans is frequently lost upon malignant transformation by silencing DTDST and ST6GalNAc6 at the early stage of colorectal carcinogenesis, and leads to production of inflammatory mediators that facilitate carcinogenesis.	Polysaccharides	27-34	solute carrier family 26 member 2	Homo sapiens	97-102
30716533-2	2019	Expression of these normal glycans is frequently lost upon malignant transformation by silencing DTDST and ST6GalNAc6 at the early stage of colorectal carcinogenesis, and leads to production of inflammatory mediators that facilitate carcinogenesis.	Polysaccharides	27-34	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	Homo sapiens	107-117
30716533-6	2019	Suppression of EZH2 substantially downregulated H3K27me3 mark and upregulated DTDST and ST6GalNAc6 as well as expression of normal glycans and Siglec-binding activities.	Polysaccharides	131-138	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	15-19
30446103-5	2019	The CIF2 polysaccharide, as the most immunostimulating polysaccharide, remarkably induced the release of nitric oxide and inflammatory cytokines including TNF-alpha, IL-1beta, IL-6 and IL-10 from RAW264.7 murine macrophage cells through NF-kappaB and PAMKs transduction signaling pathways via cell surface TLR4.	Polysaccharides	9-23	tumor necrosis factor	Mus musculus	155-164
30788740-2	2019	Natural IgM antibodies to the tetrasaccharide containing epitopes similar to surface carbohydrate structures of mammalian and human cells in low titers were determined in native mouse serum by ELISA using biotinylated tetrasaccharide and synthetic capsular polysaccharide as the solid-phase antigens.	Polysaccharides	257-271	immunoglobulin heavy constant mu	Mus musculus	8-11
30446103-5	2019	The CIF2 polysaccharide, as the most immunostimulating polysaccharide, remarkably induced the release of nitric oxide and inflammatory cytokines including TNF-alpha, IL-1beta, IL-6 and IL-10 from RAW264.7 murine macrophage cells through NF-kappaB and PAMKs transduction signaling pathways via cell surface TLR4.	Polysaccharides	9-23	interleukin 1 beta	Mus musculus	166-174
30446103-5	2019	The CIF2 polysaccharide, as the most immunostimulating polysaccharide, remarkably induced the release of nitric oxide and inflammatory cytokines including TNF-alpha, IL-1beta, IL-6 and IL-10 from RAW264.7 murine macrophage cells through NF-kappaB and PAMKs transduction signaling pathways via cell surface TLR4.	Polysaccharides	9-23	interleukin 6	Mus musculus	176-180
30446103-5	2019	The CIF2 polysaccharide, as the most immunostimulating polysaccharide, remarkably induced the release of nitric oxide and inflammatory cytokines including TNF-alpha, IL-1beta, IL-6 and IL-10 from RAW264.7 murine macrophage cells through NF-kappaB and PAMKs transduction signaling pathways via cell surface TLR4.	Polysaccharides	9-23	interleukin 10	Mus musculus	185-190
30446103-5	2019	The CIF2 polysaccharide, as the most immunostimulating polysaccharide, remarkably induced the release of nitric oxide and inflammatory cytokines including TNF-alpha, IL-1beta, IL-6 and IL-10 from RAW264.7 murine macrophage cells through NF-kappaB and PAMKs transduction signaling pathways via cell surface TLR4.	Polysaccharides	9-23	toll-like receptor 4	Mus musculus	306-310
30610060-4	2019	We show that dectin-1 and MR are critical for the recognition of tumor cells through sialic acid-specific glycan structure on their surface and for the subsequent activation of macrophage tumoricidal response.	Polysaccharides	106-112	C-type lectin domain containing 7A	Homo sapiens	13-21
30336239-0	2019	A polysaccharide from Enterobacter cloacae induces apoptosis of human osteosarcoma cells through the activation of p53 and mitochondrial intrinsic pathway.	Polysaccharides	2-16	tumor protein p53	Homo sapiens	115-118
30792861-7	2019	In return, the glycan repertoire of mucins can select for distinct mucosa-associated bacteria that are able to bind or degrade specific mucin glycans as a nutrient source.	Polysaccharides	15-21	LOC100508689	Homo sapiens	36-41
30792861-7	2019	In return, the glycan repertoire of mucins can select for distinct mucosa-associated bacteria that are able to bind or degrade specific mucin glycans as a nutrient source.	Polysaccharides	142-149	LOC100508689	Homo sapiens	36-41
30729007-2	2019	Polygalacturonase (SlPG) and expansin (SlEXP1) proteins cooperatively disassemble the polysaccharide network of tomato fruit cell walls during ripening and thereby, enable softening.	Polysaccharides	86-100	expansin	Solanum lycopersicum	29-37
30729007-2	2019	Polygalacturonase (SlPG) and expansin (SlEXP1) proteins cooperatively disassemble the polysaccharide network of tomato fruit cell walls during ripening and thereby, enable softening.	Polysaccharides	86-100	expansin	Solanum lycopersicum	39-45
30565818-4	2019	This included various Na+ -dependent transporters, osmolyte transporters and glycoside hydrolases (GH) for sulfated polysaccharide utilization in marine descendants, and in non-marine descendants genes for utilizing the land plant material pectin and genes facilitating terrestrial host interactions.	Polysaccharides	116-130	gamma-glutamyl hydrolase	Homo sapiens	77-97
30565818-4	2019	This included various Na+ -dependent transporters, osmolyte transporters and glycoside hydrolases (GH) for sulfated polysaccharide utilization in marine descendants, and in non-marine descendants genes for utilizing the land plant material pectin and genes facilitating terrestrial host interactions.	Polysaccharides	116-130	gamma-glutamyl hydrolase	Homo sapiens	99-101
30612270-0	2019	Quantitation of Glycopeptides by ESI/MS - size of the peptide part strongly affects the relative proportions and allows discovery of new glycan compositions of Ceruloplasmin.	Polysaccharides	137-143	peptidase inhibitor 3	Homo sapiens	33-36
30612270-0	2019	Quantitation of Glycopeptides by ESI/MS - size of the peptide part strongly affects the relative proportions and allows discovery of new glycan compositions of Ceruloplasmin.	Polysaccharides	137-143	ceruloplasmin	Homo sapiens	160-173
30391591-1	2019	Two water-soluble polysaccharides, BSP-1 and BSP-2, were extracted and purified from the tuber of Bletilla striata.	Polysaccharides	18-33	kallikrein related-peptidase 8	Mus musculus	35-40
30336239-1	2019	In the present study, a polysaccharide (ECP) from Enterobacter cloacae dose and time-dependently inhibited cell growth of human osteosarcoma U-2 OS cells via induction of apoptosis.	Polysaccharides	24-38	ribonuclease A family member 3	Homo sapiens	40-43
30733680-4	2018	Our results have provided evidence that the additional glycan of R27T, located at the binding interface of IFNAR2, destabilizes the interaction with IFNAR2 via steric hindrance, and simultaneously enhances the interaction with IFNAR1 by restricting the conformational freedom of R27T.	Polysaccharides	55-61	interferon alpha and beta receptor subunit 2	Homo sapiens	107-113
30413874-0	2019	Response to the letter by Dr. Naoya Yamada, and Dr. Koichi Mizuta regarding our manuscript: "Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis: more than a biomarker of liver fibrosis".	Polysaccharides	115-121	galectin 3 binding protein	Homo sapiens	93-114
30700826-3	2019	Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans.	Polysaccharides	151-158	tumor protein p73	Homo sapiens	19-22
30700826-3	2019	Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans.	Polysaccharides	151-158	transcription factor AP-2 alpha	Homo sapiens	27-30
30700826-3	2019	Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans.	Polysaccharides	151-158	neuraminidase 4	Homo sapiens	52-56
30700826-3	2019	Here we found that p73 and AP2 are able to activate NEU4, a neuraminidase gene, which removes the terminal sialic acid residues from cancer-associated glycans.	Polysaccharides	151-158	neuraminidase 1	Homo sapiens	60-73
30700826-4	2019	Under serum starvation, NEU4 was up-regulated and one of the NEU4 target glycans, sialyl Lewis X, was decreased, whereas p73 and AP2 were up-regulated.	Polysaccharides	73-80	neuraminidase 4	Homo sapiens	61-65
30564965-0	2019	Changes Due to Ageing in the Glycan Structure of Alpha-2-Macroglobulin and Its Reactivity with Ligands.	Polysaccharides	29-35	alpha-2-macroglobulin	Homo sapiens	49-70
30564965-3	2019	In this study, glycans attached to alpha2M were analysed in a human population of different ages by lectin-based protein microarray.	Polysaccharides	15-22	alpha-2-macroglobulin	Homo sapiens	35-42
30564965-7	2019	Thus, the binding of IGFBP-2 to alpha2M seems to be related to structural changes in the glycan moieties of alpha2M, whereas binding of Zn ions, most likely, is not.	Polysaccharides	89-95	insulin like growth factor binding protein 2	Homo sapiens	21-28
30564965-7	2019	Thus, the binding of IGFBP-2 to alpha2M seems to be related to structural changes in the glycan moieties of alpha2M, whereas binding of Zn ions, most likely, is not.	Polysaccharides	89-95	alpha-2-macroglobulin	Homo sapiens	32-39
30564965-7	2019	Thus, the binding of IGFBP-2 to alpha2M seems to be related to structural changes in the glycan moieties of alpha2M, whereas binding of Zn ions, most likely, is not.	Polysaccharides	89-95	alpha-2-macroglobulin	Homo sapiens	108-115
30578591-0	2019	Intact Glycopeptide Analysis of Influenza A/H1N1/09 Neuraminidase Revealing the Effects of Host and Glycosite Location on Site-Specific Glycan Structures.	Polysaccharides	136-142	neuraminidase 1	Homo sapiens	52-65
30761125-7	2019	Dendritic cells (DCs) from CBA mice differ sharply with those from BL/6 mice in that they vastly over-express the C-type lectin receptor (CLR) CD209a (SIGNR5), a homolog of human DC-SIGN, which senses glycans such as those produced by schistosome eggs.	Polysaccharides	201-208	calcitonin receptor	Mus musculus	114-136
30761125-7	2019	Dendritic cells (DCs) from CBA mice differ sharply with those from BL/6 mice in that they vastly over-express the C-type lectin receptor (CLR) CD209a (SIGNR5), a homolog of human DC-SIGN, which senses glycans such as those produced by schistosome eggs.	Polysaccharides	201-208	calcitonin receptor	Mus musculus	138-141
30761125-7	2019	Dendritic cells (DCs) from CBA mice differ sharply with those from BL/6 mice in that they vastly over-express the C-type lectin receptor (CLR) CD209a (SIGNR5), a homolog of human DC-SIGN, which senses glycans such as those produced by schistosome eggs.	Polysaccharides	201-208	CD209a antigen	Mus musculus	143-149
30761125-7	2019	Dendritic cells (DCs) from CBA mice differ sharply with those from BL/6 mice in that they vastly over-express the C-type lectin receptor (CLR) CD209a (SIGNR5), a homolog of human DC-SIGN, which senses glycans such as those produced by schistosome eggs.	Polysaccharides	201-208	CD209a antigen	Mus musculus	151-157
30733680-4	2018	Our results have provided evidence that the additional glycan of R27T, located at the binding interface of IFNAR2, destabilizes the interaction with IFNAR2 via steric hindrance, and simultaneously enhances the interaction with IFNAR1 by restricting the conformational freedom of R27T.	Polysaccharides	55-61	interferon alpha and beta receptor subunit 2	Homo sapiens	149-155
30733680-4	2018	Our results have provided evidence that the additional glycan of R27T, located at the binding interface of IFNAR2, destabilizes the interaction with IFNAR2 via steric hindrance, and simultaneously enhances the interaction with IFNAR1 by restricting the conformational freedom of R27T.	Polysaccharides	55-61	interferon alpha and beta receptor subunit 1	Homo sapiens	227-233
30366522-4	2019	From safflower, we isolated and purified a homogeneous polysaccharide, HH1-1, which could bind to and inhibit Galectin-3.	Polysaccharides	55-69	tachykinin receptor 3	Homo sapiens	71-76
30997002-6	2019	HDX-MS and activated IM-MS map the influence of glycans on the mAb and reveal allosteric effects which extend far beyond the Fc domains into the Fab region.	Polysaccharides	48-55	FA complementation group B	Homo sapiens	145-148
30543411-0	2019	Binding of the Bacterial Adhesin FimH to Its Natural, Multivalent High-Mannose Type Glycan Targets.	Polysaccharides	84-90	adhesin	Escherichia coli	25-32
30678249-0	2019	Karnofsky Performance Status as A Predictive Factor for Cancer-Related Fatigue Treatment with Astragalus Polysaccharides (PG2) Injection-A Double Blind, Multi-Center, Randomized Phase IV Study.	Polysaccharides	105-120	delta like non-canonical Notch ligand 1	Homo sapiens	122-125
30487283-5	2019	Gal-9-mediated inhibition of HCMV was dependent upon its carbohydrate recognition domains and thus dependent on glycan interactions.	Polysaccharides	112-118	galectin 9	Homo sapiens	0-5
30570258-2	2019	Because of its versatility in adopting a variety of secondary (helix or coil) and quaternary (monomer or tetramer) structures in various environments, melittin has been the focus of numerous investigations as a model peptide in protein folding studies as well as in studies involving binding to proteins, lipids, and polysaccharides.	Polysaccharides	317-332	melittin	Apis mellifera	151-159
30366522-4	2019	From safflower, we isolated and purified a homogeneous polysaccharide, HH1-1, which could bind to and inhibit Galectin-3.	Polysaccharides	55-69	galectin 3	Homo sapiens	110-120
30572707-4	2019	We have developed a simple microplate permethylation method that relies upon solid phase extraction using C18 tips to purify the permethylated glycans.	Polysaccharides	143-150	Bardet-Biedl syndrome 9	Homo sapiens	106-109
30622255-5	2019	Glycan array data show that the neutral glycans are preferentially recognised by IgM in dog sera or by mannose binding lectin when antennal fucose and phosphorylcholine residues are removed; this pattern of reactivity is reversed for mammalian C-reactive protein, which can in turn be bound by the complement component C1q.	Polysaccharides	0-6	C-reactive protein	Homo sapiens	244-262
30538100-6	2019	Evidence suggests that NTT and STK control enzyme and transporter-encoding genes involved in cell wall polysaccharide and lipid distribution in gynoecial medial domain cells.	Polysaccharides	103-117	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	31-34
30538100-7	2019	The results indicate that the simultaneous loss of NTT and STK activity affects polysaccharide and lipid deposition and septum fusion, and delays entry of septum cells to their normal degradation program.	Polysaccharides	80-94	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	59-62
30482728-3	2019	Nuclear magnetic resonance (NMR) spectra of the GluN1 LBD showed clear signals corresponding to each of the three N-glycans and indicated the reducing end of glycans at N440 and N771 potentially contacted nearby amino acids.	Polysaccharides	116-123	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	48-53
31607367-3	2019	HIV-1 Env glycans are derived from the host and present a formidable challenge for host anti-glycan antibody induction.	Polysaccharides	10-17	endogenous retrovirus group K member 20	Homo sapiens	6-9
31607367-3	2019	HIV-1 Env glycans are derived from the host and present a formidable challenge for host anti-glycan antibody induction.	Polysaccharides	10-16	endogenous retrovirus group K member 20	Homo sapiens	6-9
31607367-4	2019	Anti-glycan antibody induction is challenging because anti-HIV-1 glycan antibodies should recognize Env antigen while not acquiring autoreactivity.	Polysaccharides	5-11	endogenous retrovirus group K member 20	Homo sapiens	100-103
31607367-4	2019	Anti-glycan antibody induction is challenging because anti-HIV-1 glycan antibodies should recognize Env antigen while not acquiring autoreactivity.	Polysaccharides	65-71	endogenous retrovirus group K member 20	Homo sapiens	100-103
31607367-5	2019	Thus, the glycan network on HIV-1 Env is referred to as the glycan shield.	Polysaccharides	10-16	endogenous retrovirus group K member 20	Homo sapiens	34-37
31607367-5	2019	Thus, the glycan network on HIV-1 Env is referred to as the glycan shield.	Polysaccharides	60-66	endogenous retrovirus group K member 20	Homo sapiens	34-37
31607367-6	2019	Despite the challenges presented by immune recognition of host-derived glycans, neutralizing antibodies capable of binding the glycans on HIV-1 Env can be generated by the host immune system in the setting of HIV-1 infection.	Polysaccharides	71-78	endogenous retrovirus group K member 20	Homo sapiens	144-147
31607367-6	2019	Despite the challenges presented by immune recognition of host-derived glycans, neutralizing antibodies capable of binding the glycans on HIV-1 Env can be generated by the host immune system in the setting of HIV-1 infection.	Polysaccharides	127-134	endogenous retrovirus group K member 20	Homo sapiens	144-147
30286260-5	2019	RESULTS: The MAM assay is shown to be suitable for use as a combined method for identity testing, glycan profiling, and protein ratio determination for co-formulated monoclonal antibody (mAb) drugs.	Polysaccharides	98-104	sarcoglycan gamma	Homo sapiens	13-16
30286260-11	2019	CONCLUSIONS: The suitability of this MAM for use in a quality control setting is demonstrated through assessment specificity for mAb identity, and accuracy, precision, linearity and robustness for glycan profiling and ratio determination.	Polysaccharides	197-203	sarcoglycan gamma	Homo sapiens	37-40
30382946-2	2019	Lack of sialylated glycans due to genetic ablation of the Sia-activating enzyme CMP-sialic acid synthase (CMAS) resulted in embryonic lethality around day 9.5 post coitum (E9.5) in mice.	Polysaccharides	19-26	cytidine monophospho-N-acetylneuraminic acid synthetase	Mus musculus	80-104
30382946-2	2019	Lack of sialylated glycans due to genetic ablation of the Sia-activating enzyme CMP-sialic acid synthase (CMAS) resulted in embryonic lethality around day 9.5 post coitum (E9.5) in mice.	Polysaccharides	19-26	cytidine monophospho-N-acetylneuraminic acid synthetase	Mus musculus	106-110
30603813-0	2019	Correction to: Creation of Straight-Chain Cationic Polysaccharide-Based Bile Salt Sequestrants Made from Euglenoid beta-1,3-Glucan as Potential Antidiabetic Agents.	Polysaccharides	51-65	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	115-123
30609723-2	2019	Hepatoprotective effects of a purified T. orientalis polysaccharide (TOP-2) were evaluated by alcohol-induced liver injury model mice.	Polysaccharides	53-67	topoisomerase (DNA) II alpha	Mus musculus	69-74
30729434-3	2019	Extracellular glycans can affect EGFR expression, dimerization, phosphorylation, and EGF binding.	Polysaccharides	14-21	epidermal growth factor receptor	Homo sapiens	33-37
31122040-0	2019	Astragalus Polysaccharide Eases G1 Phase-Correlative Bystander Effects through Mediation of TGF- beta R/MAPK/ROS Signal Pathway After Carbon Ion Irradiation in BMSCs.	Polysaccharides	11-25	mitogen-activated protein kinase 1	Homo sapiens	104-108
30622255-5	2019	Glycan array data show that the neutral glycans are preferentially recognised by IgM in dog sera or by mannose binding lectin when antennal fucose and phosphorylcholine residues are removed; this pattern of reactivity is reversed for mammalian C-reactive protein, which can in turn be bound by the complement component C1q.	Polysaccharides	0-6	complement C1q A chain	Homo sapiens	319-322
30622255-5	2019	Glycan array data show that the neutral glycans are preferentially recognised by IgM in dog sera or by mannose binding lectin when antennal fucose and phosphorylcholine residues are removed; this pattern of reactivity is reversed for mammalian C-reactive protein, which can in turn be bound by the complement component C1q.	Polysaccharides	40-47	C-reactive protein	Homo sapiens	244-262
30622255-5	2019	Glycan array data show that the neutral glycans are preferentially recognised by IgM in dog sera or by mannose binding lectin when antennal fucose and phosphorylcholine residues are removed; this pattern of reactivity is reversed for mammalian C-reactive protein, which can in turn be bound by the complement component C1q.	Polysaccharides	40-47	complement C1q A chain	Homo sapiens	319-322
30455330-0	2019	Plasma Fucosylated Glycans and C-Reactive Protein as Biomarkers of HNF1A-MODY in Young Adult-Onset Nonautoimmune Diabetes.	Polysaccharides	19-26	HNF1 homeobox A	Homo sapiens	67-72
30788353-0	2019	Behavioral defects induced by chronic social defeat stress are protected by Momordica charantia polysaccharides via attenuation of JNK3/PI3K/AKT neuroinflammatory pathway.	Polysaccharides	96-111	mitogen-activated protein kinase 10	Mus musculus	131-135
30788353-0	2019	Behavioral defects induced by chronic social defeat stress are protected by Momordica charantia polysaccharides via attenuation of JNK3/PI3K/AKT neuroinflammatory pathway.	Polysaccharides	96-111	thymoma viral proto-oncogene 1	Mus musculus	141-144
29998822-2	2019	The anti-glycan antibodies: anti-laminaribioside, anti-chitobioside, and anti-mannobioside carbohydrate antibodies (ALCA, ACCA, and AMCA) are serological markers previously associated with IBD.	Polysaccharides	9-15	G protein-coupled receptor 3	Homo sapiens	122-126
30342127-1	2019	In the present study, the physicochemical properties of polysaccharides from corn silk (CSP) with different molecular weights were characterized and their inhibitory actions against alpha-glucosidase and alpha-amylase were evaluated.	Polysaccharides	56-71	DnaJ heat shock protein family (Hsp40) member C5	Rattus norvegicus	88-91
30843179-9	2019	The increased sialylation of TSHR glycans correlates positively with the receptor binding ability and prolongs the time of receptor incorporation into the cell membrane.	Polysaccharides	34-41	thyroid stimulating hormone receptor	Homo sapiens	29-33
30732524-0	2019	Promoter orientation of the immunomodulatory Bacteroides fragilis capsular polysaccharide A (PSA) is off in individuals with inflammatory bowel disease (IBD).	Polysaccharides	75-89	aminopeptidase puromycin sensitive	Homo sapiens	93-96
30732524-2	2019	In addition, B. fragilis can produce multiple capsular polysaccharides that comprise a microcapsule layer, including an immunomodulatory, zwitterionic, polysaccharide A (PSA) capable of stimulating anti-inflammatory interleukin-10 (IL-10) production.	Polysaccharides	55-70	aminopeptidase puromycin sensitive	Homo sapiens	170-173
31762322-4	2019	Semi-synthetic glycosaminoglycan ethers (SAGEs) are sulfated polysaccharides derived from hyaluronic acid that inhibit RAGE signaling.	Polysaccharides	61-76	advanced glycosylation end product-specific receptor	Mus musculus	119-123
30204870-7	2019	Overall, our findings increase understanding as to how galactans interact with Gal-3 at the non-reducing, terminal end of galactose-containing polysaccharides as found on the cell surface.	Polysaccharides	143-158	galectin 3	Homo sapiens	79-84
30342127-1	2019	In the present study, the physicochemical properties of polysaccharides from corn silk (CSP) with different molecular weights were characterized and their inhibitory actions against alpha-glucosidase and alpha-amylase were evaluated.	Polysaccharides	56-71	alpha-amylase	Zea mays	204-217
30806252-4	2019	However, the methylation results indicated that FPS, IPS, and EPS possessed different polysaccharide structures.	Polysaccharides	86-100	farnesyl diphosphate synthetase	Mus musculus	48-51
30838615-6	2019	Finally, the NPs are functionalized with hyaluronic acid, a polysaccharide which targets the CD44 receptor.	Polysaccharides	60-74	CD44 molecule (Indian blood group)	Homo sapiens	93-97
30557873-3	2019	We showed that the low- molecular-weight fucoidan (LMW-Fuc), a polysaccharide extracted from brown algae, attenuated the exacerbated activation induced by fMLP on LPS-primed PMNs, in vitro, impairing chemotaxis, NET formation, and the pro-survival and pro-oxidative effects.	Polysaccharides	63-77	formyl peptide receptor 1	Homo sapiens	155-159
30471282-2	2019	Siglec-9, expressed on human neutrophils and macrophages, engages specific glycan ligands on tissues to diminish ongoing inflammation.	Polysaccharides	75-81	sialic acid binding Ig like lectin 9	Homo sapiens	0-8
31030762-6	2019	PSS is produced by modifying partially hydrolyzed alginate, one of the most abundant marine polysaccharides isolated from brown algae, by epoxypropane esterification and by chemical sulfation.	Polysaccharides	92-107	PSS	Homo sapiens	0-3
30257876-3	2019	On-chip glycan modification and probing (on-chip gmap) uses sequential and parallel rounds of exoglycosidase cleavage and lectin profiling of microspots of proteins, together with algorithms that incorporate glycan-array analyses and information from mass spectrometry, when available, to computationally interpret the data.	Polysaccharides	8-14	galanin and GMAP prepropeptide	Homo sapiens	49-53
30257876-3	2019	On-chip glycan modification and probing (on-chip gmap) uses sequential and parallel rounds of exoglycosidase cleavage and lectin profiling of microspots of proteins, together with algorithms that incorporate glycan-array analyses and information from mass spectrometry, when available, to computationally interpret the data.	Polysaccharides	208-214	galanin and GMAP prepropeptide	Homo sapiens	49-53
30257876-4	2019	In tests on control proteins with simple or complex glycosylation, on-chip gmap accurately characterized the relative proportions of core types and terminal features of glycans.	Polysaccharides	169-176	galanin and GMAP prepropeptide	Homo sapiens	75-79
30257876-7	2019	An alternative use of on-chip gmap was to complement the mass spectrometry analysis of detached glycans by specifying the isomers that comprise the glycans identified by mass spectrometry.	Polysaccharides	96-103	galanin and GMAP prepropeptide	Homo sapiens	30-34
30257876-7	2019	An alternative use of on-chip gmap was to complement the mass spectrometry analysis of detached glycans by specifying the isomers that comprise the glycans identified by mass spectrometry.	Polysaccharides	148-155	galanin and GMAP prepropeptide	Homo sapiens	30-34
30905461-2	2019	Sialic acid (SA) generally occurs as the terminal monosaccharide on the glycans.	Polysaccharides	72-79	acyl-CoA synthetase medium chain family member 3	Homo sapiens	13-15
30905445-5	2019	Later on, the glycan-related biomarkers were detected in the sera of cancer patients and then developed into serum biomarkers, such as CA125, CA153, CA195, CA199, CA242, CA27.29, CA50, and CA724, which are still in clinical use as of today.	Polysaccharides	14-20	mucin 16, cell surface associated	Homo sapiens	135-140
30905445-5	2019	Later on, the glycan-related biomarkers were detected in the sera of cancer patients and then developed into serum biomarkers, such as CA125, CA153, CA195, CA199, CA242, CA27.29, CA50, and CA724, which are still in clinical use as of today.	Polysaccharides	14-20	mucin 1, cell surface associated	Homo sapiens	142-147
31080188-3	2019	The CSF contains two Tf isoforms, brain-type Tf and serum-type Tf, which differ in their glycan structures.	Polysaccharides	89-95	transferrin	Homo sapiens	21-23
31080188-5	2019	The glycans of serum-type Tf in the CSF are similar to those of Tf in serum.	Polysaccharides	4-11	transferrin	Homo sapiens	26-28
30619375-4	2018	Underscoring the importance of IL-6 in TFH generation, we found improved antibody responses accompanied by increased TFH cells and decreased follicular regulatory helper T (TFR) cells, a Foxp3 expressing inhibitory CD4+ T cell occupying the germinal center (GC), when a tetanus toxoid conjugated pneumococcal polysaccharide type 14 vaccine was injected in adult mice together with IL-6.	Polysaccharides	309-323	interleukin 6	Mus musculus	31-35
30566283-3	2019	Three kinds of bicycle [6.1.0] nonyne (BCN)-modified sugars are designed and synthesized, in which Ac4 ManN-BCN shows efficient incorporation into wide tumor cells with a BCN motif on surface glycans.	Polysaccharides	192-199	adenylate cyclase 4	Homo sapiens	99-102
30583568-4	2018	The alkali extraction (AAMP) was identified as a polysaccharide-enriched fraction.	Polysaccharides	49-63	angio-associated, migratory cell protein	Rattus norvegicus	23-27
30457869-1	2018	Inhibitors of human neuraminidase enzymes (NEU) are recognized as important tools for the study of the biological functions of NEU and will be potent tools for elucidating the role of these enzymes in regulating the repertoire of cellular glycans.	Polysaccharides	239-246	neuraminidase 1	Homo sapiens	20-33
30457869-1	2018	Inhibitors of human neuraminidase enzymes (NEU) are recognized as important tools for the study of the biological functions of NEU and will be potent tools for elucidating the role of these enzymes in regulating the repertoire of cellular glycans.	Polysaccharides	239-246	neuraminidase 1	Homo sapiens	43-46
30623115-1	2019	During inflammation, the covalent linking of the ubiquitous extracellular polysaccharide hyaluronan (HA) with the heavy chains (HC) of the serum protein inter alpha inhibitor (IalphaI) is exclusively mediated by the enzyme tumor necrosis factor alpha (TNFalpha)-stimulated-gene-6 (TSG-6).	Polysaccharides	74-88	tumor necrosis factor	Homo sapiens	252-260
30623115-1	2019	During inflammation, the covalent linking of the ubiquitous extracellular polysaccharide hyaluronan (HA) with the heavy chains (HC) of the serum protein inter alpha inhibitor (IalphaI) is exclusively mediated by the enzyme tumor necrosis factor alpha (TNFalpha)-stimulated-gene-6 (TSG-6).	Polysaccharides	74-88	tumor necrosis factor alpha induced protein 6	Mus musculus	281-286
30348809-10	2018	This study expands the repertoire of oncogenic mutations in CSF3R that are therapeutically targetable and provides insight into the function of glycans in receptor regulation.	Polysaccharides	144-151	colony stimulating factor 3 receptor	Homo sapiens	60-65
30560888-5	2018	Using intra-individual normalization of the main agalactosylated glycan (FA2) of IgG1 vs FA2-IgG2, ASS/IIM and controls were distinguished with an area under the curve (AUC) of 79 +- 6%.	Polysaccharides	65-71	FA complementation group B	Homo sapiens	73-76
30287023-1	2018	This proposed work aimed to investigate the chemical characteristic, antioxidant capacities and hepatoprotection effect of pomegranate peel polysaccharides (PPP) on CCl4-induced oxidative damage in mice.	Polysaccharides	140-155	chemokine (C-C motif) ligand 4	Mus musculus	165-169
30427356-3	2018	HDBPs (crude Huidouba polysaccharide (CHDBP), HDBP-1 and HDBP-2) exhibited significant antioxidant and alpha-glucosidase inhibitory activities in vitro.	Polysaccharides	22-36	sucrase isomaltase (alpha-glucosidase)	Mus musculus	103-120
30305355-1	2019	The HIV-1 envelope (Env) glycans shield the surface of Env from the immune system and form integral interactions important for a functional Env.	Polysaccharides	25-32	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	20-23
30305355-1	2019	The HIV-1 envelope (Env) glycans shield the surface of Env from the immune system and form integral interactions important for a functional Env.	Polysaccharides	25-32	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	55-58
30305355-1	2019	The HIV-1 envelope (Env) glycans shield the surface of Env from the immune system and form integral interactions important for a functional Env.	Polysaccharides	25-32	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	55-58
30333166-6	2019	Our study elucidates the structural adaptations of the GII.17/13/21 lineage through distinct evolutionary paths, which may allow a theory explaining huNoV adaptations and evolutions to be put forward.IMPORTANCE Our understanding of the molecular bases behind the interplays between human noroviruses and their host glycan ligands, as well as their evolutionary changes over time with alterations in their host ligand binding capability and host susceptibility, remains limited.	Polysaccharides	315-321	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	16-17
30333166-8	2019	We present solid evidence on how noroviruses of this genetic lineage evolved via different evolutionary paths to (i) optimize their glycan binding site for higher glycan binding function and (ii) acquire a completely new glycan binding site for new ligands.	Polysaccharides	132-138	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	65-66
30333166-8	2019	We present solid evidence on how noroviruses of this genetic lineage evolved via different evolutionary paths to (i) optimize their glycan binding site for higher glycan binding function and (ii) acquire a completely new glycan binding site for new ligands.	Polysaccharides	163-169	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	65-66
30333166-8	2019	We present solid evidence on how noroviruses of this genetic lineage evolved via different evolutionary paths to (i) optimize their glycan binding site for higher glycan binding function and (ii) acquire a completely new glycan binding site for new ligands.	Polysaccharides	163-169	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	65-66
30523487-0	2018	Creation of Straight-Chain Cationic Polysaccharide-Based Bile Salt Sequestrants Made from Euglenoid beta-1,3-Glucan as Potential Antidiabetic Agents.	Polysaccharides	36-50	hemoglobin, beta adult major chain	Mus musculus	100-108
30327429-5	2018	Although GAUT1:GAUT7 synthesized high-molecular-weight polymeric HG (&gt;100 kDa) in a substrate concentration-dependent manner typical of distributive (nonprocessive) glycosyltransferases with DP11 acceptors, reactions primed with short-chain acceptors resulted in a bimodal product distribution of glycan products that has previously been reported as evidence for a processive model of GT elongation.	Polysaccharides	300-306	galacturonosyltransferase 1	Arabidopsis thaliana	9-14
30327429-5	2018	Although GAUT1:GAUT7 synthesized high-molecular-weight polymeric HG (&gt;100 kDa) in a substrate concentration-dependent manner typical of distributive (nonprocessive) glycosyltransferases with DP11 acceptors, reactions primed with short-chain acceptors resulted in a bimodal product distribution of glycan products that has previously been reported as evidence for a processive model of GT elongation.	Polysaccharides	300-306	galacturonosyltransferase 7	Arabidopsis thaliana	15-20
30523487-2	2018	The feasibility of using cationic polysaccharides made from euglenoid beta-1,3-glucan (referred to as paramylon) as potential antidiabetic agents was examined by using in vitro and animal experiments.	Polysaccharides	34-49	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	70-78
29924384-1	2018	Cell surface glycans, which are tissue-specific and developmentally regulated, work as essential modulators in ligand-receptor interactions, binding to various signal ligands including Wnt, Hedgehog, fibroblast growth factors, epidermal growth factors, and bone morphogenetic proteins, as well as in cell-cell interactions and cell-extracellular matrix interactions.	Polysaccharides	13-20	hedgehog	Drosophila melanogaster	190-198
29087497-0	2018	Polysaccharide-experienced effector T cells induce IL-10 in FoxP3+ regulatory T cells to prevent pulmonary inflammation.	Polysaccharides	0-14	interleukin 10	Mus musculus	51-56
29087497-0	2018	Polysaccharide-experienced effector T cells induce IL-10 in FoxP3+ regulatory T cells to prevent pulmonary inflammation.	Polysaccharides	0-14	forkhead box P3	Mus musculus	60-65
30170057-4	2018	The polysaccharide-based nanoparticles as delivery vehicles for insulin oral administration have recently attracted substantial interests.	Polysaccharides	4-18	insulin	Homo sapiens	64-71
30170057-5	2018	The present review highlights the recent advances on the development of nanoparticles prepared from polysaccharides, including chitosan, alginate, dextran and glucan, for oral delivery of insulin, overcoming multiple barriers in gastrointestinal tract.	Polysaccharides	100-115	insulin	Homo sapiens	188-195
30170057-6	2018	The aims of this review are first to summarize the strategies that have been applied in the past 5 years to fabricate polysaccharide-based nanoparticles for insulin oral delivery, and then to provide in-depth understanding on the mechanisms by which such nanoparticles protect insulin against degradation in the digestive tract and provide sustained release to enhance mucus permeation and transepithelial transport of insulin administered via oral route.	Polysaccharides	118-132	insulin	Homo sapiens	157-164
30170057-6	2018	The aims of this review are first to summarize the strategies that have been applied in the past 5 years to fabricate polysaccharide-based nanoparticles for insulin oral delivery, and then to provide in-depth understanding on the mechanisms by which such nanoparticles protect insulin against degradation in the digestive tract and provide sustained release to enhance mucus permeation and transepithelial transport of insulin administered via oral route.	Polysaccharides	118-132	insulin	Homo sapiens	277-284
30171943-2	2018	Three water-soluble polysaccharides, designated as CYZ, CYS-1, CYS-2, were purified and the molecular weight were found to be 22 KDa, 41 KDa and 23 KDa, respectively.	Polysaccharides	20-35	cystin 1	Mus musculus	56-61
30171943-6	2018	The antioxidant activities increased in the order of CYS-1 &lt; CYZ &lt; CYS-2 &lt; crude polysaccharide.	Polysaccharides	90-104	cystin 1	Mus musculus	53-58
30171943-7	2018	Further, crude polysaccharide CYS-1 (&gt;=80 mug/mL) had a good ability of inhibiting alpha-glucosidase and significant inhibition on the relative proliferation rate of B16 murine melanoma cells middle dose (&gt;=200 mug/mL).	Polysaccharides	15-29	cystin 1	Mus musculus	30-35
30171943-7	2018	Further, crude polysaccharide CYS-1 (&gt;=80 mug/mL) had a good ability of inhibiting alpha-glucosidase and significant inhibition on the relative proliferation rate of B16 murine melanoma cells middle dose (&gt;=200 mug/mL).	Polysaccharides	15-29	sucrase isomaltase (alpha-glucosidase)	Mus musculus	86-103
30171947-0	2018	Sarcodon imbricatus polysaccharides protect against cyclophosphamide-induced immunosuppression via regulating Nrf2-mediated oxidative stress.	Polysaccharides	20-35	nuclear factor, erythroid derived 2, like 2	Mus musculus	110-114
30509199-12	2018	In addition, we found that VH3/JH4 was the predominant germline sequence used in these polysaccharide-specific B cells.	Polysaccharides	87-101	immunoglobulin heavy variable 3-75 (pseudogene)	Homo sapiens	27-30
30064769-3	2018	The obtained results indicate that the polysaccharide fraction from C. cibarius inhibits the activity of both COX-1 and COX-2.	Polysaccharides	39-53	cox1	Cantharellus cibarius	110-115
30064769-3	2018	The obtained results indicate that the polysaccharide fraction from C. cibarius inhibits the activity of both COX-1 and COX-2.	Polysaccharides	39-53	cox2	Cantharellus cibarius	120-125
30171950-0	2018	Polysaccharide isolated from Sarcodon aspratus induces RAW264.7 activity via TLR4-mediated NF-kappaB and MAPK signaling pathways.	Polysaccharides	0-14	toll-like receptor 4	Mus musculus	77-81
30171950-1	2018	Our previous report showed that the novel polysaccharide SAP isolated from the fruiting bodies of Sarcodon aspratus induced Hela cells apoptosis via mitochondrial dysfunction.	Polysaccharides	42-56	SH2 domain containing 1A	Mus musculus	57-60
30171960-0	2018	Polysaccharide FMP-1 from Morchella esculenta attenuates cellular oxidative damage in human alveolar epithelial A549 cells through PI3K/AKT/Nrf2/HO-1 pathway.	Polysaccharides	0-14	AKT serine/threonine kinase 1	Homo sapiens	136-139
30171960-0	2018	Polysaccharide FMP-1 from Morchella esculenta attenuates cellular oxidative damage in human alveolar epithelial A549 cells through PI3K/AKT/Nrf2/HO-1 pathway.	Polysaccharides	0-14	NFE2 like bZIP transcription factor 2	Homo sapiens	140-144
30287368-2	2018	In the present study, a polysaccharide named PIP-1 was obtained from Phellinus igniarius mycelia, its physicochemical properties were determined, its detailed structures were elucidated by analysis of its depolymerized product, and its antioxidant and antitumor activities were evaluated.	Polysaccharides	24-38	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	45-50
30498196-4	2018	Sialylated complex glycans on FcgammaRIIA interact with the alphaI-domain via divalent cations, and this interaction is required for FcgammaRIIA inhibition by Mac-1.	Polysaccharides	19-26	integrin subunit alpha M	Homo sapiens	159-164
30274067-4	2018	Zein and GA polymers were used as a protein and polysaccharide component of the scaffold and PCL polymer for elasticity, strength and time setting of scaffold degradability.	Polysaccharides	48-62	zein	Zea mays	0-4
30453343-10	2018	CONCLUSION:  The "novel" anti-inflammatory effects of C1-inh are unlikely due to SLeX on C1-inh and can in fact be due to SLeX-like glycans on ACT, present in C1-inh products.	Polysaccharides	132-139	serpin family G member 1	Homo sapiens	54-60
30397344-4	2018	We use germ-free apolipoprotein E-deficient mice colonized with synthetic microbial communities that differ in their capacity to generate butyrate to demonstrate that Roseburia intestinalis interacts with dietary plant polysaccharides to: impact gene expression in the intestine, directing metabolism away from glycolysis and toward fatty acid utilization; lower systemic inflammation; and ameliorate atherosclerosis.	Polysaccharides	219-234	apolipoprotein E	Mus musculus	17-33
30230652-6	2018	Finally, we find that P. merdae GUS is able to bind to homo and heteropolymers of the polysaccharide alginic acid.	Polysaccharides	86-100	glucuronidase beta	Homo sapiens	32-35
30301767-6	2018	Together, these data highlight the diversity of GUS enzymes within a single Bacteroides gut commensal and advance our understanding of how structural details impact the specific roles microbial enzymes play in processing drug-glucuronide and glycan substrates.	Polysaccharides	242-248	glucuronidase beta	Homo sapiens	48-51
30420978-1	2018	We present the preparation, morphological analysis, and rheological characterization of ultra-low solid content gels prepared by physically cross-linking TEMPO-oxidized cellulose nanofibrils (TEMPO-CNF) with the soluble plant-cell-wall polysaccharide, mixed-linkage beta-glucan (MLG).	Polysaccharides	236-250	NPHS1 adhesion molecule, nephrin	Homo sapiens	198-201
29939289-5	2018	Discussion: Removal of the mucin-like domain and glycan cap from the GP of members of the Ebolavirus genus presumably exposes conserved epitopes in or in the vicinity of the receptor binding site and internal fusion loop that are readily amenable to neutralization.	Polysaccharides	49-55	ring finger protein 130	Homo sapiens	69-71
30282635-0	2018	Mini-GAGR, an intranasally applied polysaccharide, activates the neuronal Nrf2-mediated antioxidant defense system.	Polysaccharides	35-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	74-78
30282635-6	2018	Here, we discovered a BBB-bypassing Nrf2-activating polysaccharide that may attenuate AD pathogenesis.	Polysaccharides	52-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	36-40
30282635-11	2018	The BBB-bypassing Nrf2-activating polysaccharide reported here may be effective in reducing oxidative stress and neurodegeneration in AD.	Polysaccharides	34-48	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
30481169-3	2018	Here, we carried out Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9-mediated genome-wide loss-of-function screens using two related bacterial toxins, Shiga-like toxins (Stxs) 1 and 2, which use a specific glycolipid, globotriaosylceramide (Gb3), as receptors, and the plant toxin ricin, which recognizes a broad range of glycans.	Polysaccharides	346-353	syntaxin 1A	Homo sapiens	175-207
30336974-10	2018	Particularly, MTOG on CD43 was differentially inhibited in K562 and U937 as revealed by glycan-dependent and glycan-independent antibodies.	Polysaccharides	88-94	sialophorin	Homo sapiens	22-26
30380836-7	2018	This new approach enables quick preparation of glycan microarrays and neoglycoproteins from glycan-AA conjugates, which can be separated by weak anion exchange (WAX) and C18 reversed-phase HPLC.	Polysaccharides	47-53	Bardet-Biedl syndrome 9	Homo sapiens	170-173
30336974-10	2018	Particularly, MTOG on CD43 was differentially inhibited in K562 and U937 as revealed by glycan-dependent and glycan-independent antibodies.	Polysaccharides	109-115	sialophorin	Homo sapiens	22-26
30424528-2	2018	In the study, Monostroma sulfated polysaccharide (MSP) was obtained from Monostroma angicava, and the low-molecular-weight fragments of MSP (MSP-Fs: MSP-F1-MSP-F6) were prepared by controlled acid degradation.	Polysaccharides	34-48	leishmanolysin like peptidase	Homo sapiens	50-53
30252451-4	2018	A cellulose sulfate with irregular sulfation pattern along the polysaccharide backbone (13-TACS-01) led to an additional increase in vascular endothelial growth factor (VEGF)-induced tubule formation, as observed in an in vitro angiogenesis assays.	Polysaccharides	63-77	vascular endothelial growth factor A	Homo sapiens	133-167
30252451-4	2018	A cellulose sulfate with irregular sulfation pattern along the polysaccharide backbone (13-TACS-01) led to an additional increase in vascular endothelial growth factor (VEGF)-induced tubule formation, as observed in an in vitro angiogenesis assays.	Polysaccharides	63-77	vascular endothelial growth factor A	Homo sapiens	169-173
30177190-0	2018	Polysaccharide isolated from Phellinus linteus mycelia exerts anti-inflammatory effects via MAPK and PPAR signaling pathways.	Polysaccharides	0-14	peroxisome proliferator activated receptor alpha	Mus musculus	101-105
30295034-7	2018	From pooled human plasma, we find 90, 101, and 64 different glycan compositions for genetic variants ORM1*F1, ORM1*S, and ORM2, respectively.	Polysaccharides	60-66	orosomucoid 1	Homo sapiens	101-105
30217822-2	2018	FH comprises 20 short complement regulator (SCR) domains, including eight glycans, and its Y402H polymorphism predisposes those who carry it to age-related macular degeneration.	Polysaccharides	74-81	complement factor H	Homo sapiens	0-2
30395637-3	2018	Glycans bordering the CD4bs impede the binding of germline-reverted forms of VRC01-class bnAbs and therefore constitute a barrier to early events in initiating the correct antibody lineages.	Polysaccharides	0-7	CD4 molecule	Homo sapiens	22-25
30395637-4	2018	Deleting a subset of these glycans permits Env antigen binding but not virus neutralization, suggesting that additional barriers impede germline-reverted VRC01-class antibody binding to functional Env trimers.	Polysaccharides	27-34	endogenous retrovirus group K member 20	Homo sapiens	43-46
30395637-4	2018	Deleting a subset of these glycans permits Env antigen binding but not virus neutralization, suggesting that additional barriers impede germline-reverted VRC01-class antibody binding to functional Env trimers.	Polysaccharides	27-34	endogenous retrovirus group K member 20	Homo sapiens	197-200
30295034-7	2018	From pooled human plasma, we find 90, 101, and 64 different glycan compositions for genetic variants ORM1*F1, ORM1*S, and ORM2, respectively.	Polysaccharides	60-66	orosomucoid 1	Homo sapiens	110-114
30295034-7	2018	From pooled human plasma, we find 90, 101, and 64 different glycan compositions for genetic variants ORM1*F1, ORM1*S, and ORM2, respectively.	Polysaccharides	60-66	orosomucoid 2	Homo sapiens	122-126
29685495-1	2018	ST6Gal1 is a critical sialyltransferase enzyme that controls the addition of alpha2,6-linked sialic acids to the termini of glycans.	Polysaccharides	124-131	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	0-7
29934665-5	2018	Glycan-inhibitable surface binding of galectin-8 to these cells increased gene transcription and the secretion of functional disease markers.	Polysaccharides	0-6	galectin 8	Homo sapiens	38-48
30195140-6	2018	The polysaccharide has been shown to have the capacity to induce Th1 cell responses following vaccination by injection or mucosal routes, supporting its application as an alternative to alum for vaccines that promote cell-mediated immunity.	Polysaccharides	4-18	negative elongation factor complex member C/D	Homo sapiens	65-68
29909237-8	2018	The addition of glycans to N-linked proteins is catalyzed by the enzymatic activity of N-acetylglucosaminyltransferases (GnTs), which regulates the glycosylation status of key angiogenic factors such as VEGF receptor 2 (VEGFR2) and Notch.	Polysaccharides	16-23	kinase insert domain receptor	Homo sapiens	203-218
30481821-2	2018	Recent reports indicate that transmembrane mucins and galectin-3, a chimera type of galectin that binds beta-galactoside in the glycan, play a crucial role in maintaining the epithelial glycocalyx barrier.	Polysaccharides	128-134	galectin 3	Homo sapiens	54-64
30783327-0	2018	Sulfated polysaccharides of seagrass Halophila ovalis suppresses tumor necrosis factor-alpha-induced chemokine interleukin-8 secretion in HT-29 cell line.	Polysaccharides	9-24	tumor necrosis factor	Homo sapiens	65-92
30783327-0	2018	Sulfated polysaccharides of seagrass Halophila ovalis suppresses tumor necrosis factor-alpha-induced chemokine interleukin-8 secretion in HT-29 cell line.	Polysaccharides	9-24	C-X-C motif chemokine ligand 8	Homo sapiens	111-124
30333662-2	2018	High extraction yields were obtained for CP1 (17.6%) and CP2 (5.2%) polysaccharides.	Polysaccharides	68-83	cleft palate 2	Mus musculus	57-60
29909237-8	2018	The addition of glycans to N-linked proteins is catalyzed by the enzymatic activity of N-acetylglucosaminyltransferases (GnTs), which regulates the glycosylation status of key angiogenic factors such as VEGF receptor 2 (VEGFR2) and Notch.	Polysaccharides	16-23	kinase insert domain receptor	Homo sapiens	220-226
30377844-3	2018	Two kinds of polysaccharides in the leaves, DLP-1 and DLP-2, were obtained by hot water extraction, alcohol sedimentation and chromatographic separation (DEAE-52 cellulose column and Sephadex G-100 column).	Polysaccharides	13-28	dynamin 1 like	Homo sapiens	44-49
30593334-9	2018	RESULTS: Compared with the model group, the infarct size of the rats pretreated with polysaccharides decreased significantly, The levels of MDA, CK, CK-MB in serum and TNF-alpha, IL-1, IL-6 in myocardium were significantly decreased.	Polysaccharides	85-100	tumor necrosis factor	Rattus norvegicus	168-177
30593334-9	2018	RESULTS: Compared with the model group, the infarct size of the rats pretreated with polysaccharides decreased significantly, The levels of MDA, CK, CK-MB in serum and TNF-alpha, IL-1, IL-6 in myocardium were significantly decreased.	Polysaccharides	85-100	interleukin 6	Rattus norvegicus	185-189
30296068-0	2018	Comparative Site-Specific N-Glycosylation Analysis of Lactoperoxidase from Buffalo and Goat Milk Using RP-UHPLC-MS/MS Reveals a Distinct Glycan Pattern.	Polysaccharides	137-143	lactoperoxidase	Capra hircus	54-69
30296068-7	2018	The presence of glycan isomers in buffalo and goat LPO was also observed.	Polysaccharides	16-22	lactoperoxidase	Capra hircus	51-54
30425545-0	2018	Astragalus polysaccharides inhibit oxidation in high glucose-challenged or SOD2-silenced H9C2 cells.	Polysaccharides	11-26	superoxide dismutase 2	Rattus norvegicus	75-79
30411039-5	2018	In this study, bovine serum albumin (BSA)-phenylboronic acid (PBA) conjugates were synthesized in a density-controlled manner by targeting both aspartic and glutamic acids to afford lectin mimetics with multivalent PBA, as multivalency is a key factor for glycan recognition in both specificity and affinity.	Polysaccharides	256-262	albumin	Homo sapiens	22-35
30158294-5	2018	We used various glycosidases to establish that virion-associated SERINC5 is modified by N-linked, complex glycans, whereas the majority of SERINC5 in cells is of relatively low molecular weight and is modified by high-mannose glycans.	Polysaccharides	106-113	serine incorporator 5	Homo sapiens	65-72
29958959-3	2018	AIMS OF THE STUDY: The purpose of the present study is to characterize the polysaccharide from L. europaeum L. leaves (LEP) and to explore its antioxidant, anti-inflammatory and hepato-nephroprotective properties.	Polysaccharides	75-89	leptin	Mus musculus	119-122
30367085-4	2018	Here, we employed an inverse method to measure the loss of specific wood polysaccharides in the oak cask during aging for up to ten years.	Polysaccharides	73-88	calcium/calmodulin dependent serine protein kinase	Homo sapiens	100-104
30093037-6	2018	This type of interactions could improve the biological activities of polysaccharides such as alpha-amylase and alpha-glucosidase inhibition.	Polysaccharides	69-84	alpha-amylase	Zea mays	93-106
30355496-0	2018	Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth.	Polysaccharides	31-37	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	22-30
30355496-3	2018	To understand the interplay between glycan holes and neutralization breadth in HIV-1 infection, we developed a sequence- and structure-based approach to identify glycan holes for individual Env sequences that are shielded in most M-group viruses.	Polysaccharides	36-42	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	190-193
30355496-3	2018	To understand the interplay between glycan holes and neutralization breadth in HIV-1 infection, we developed a sequence- and structure-based approach to identify glycan holes for individual Env sequences that are shielded in most M-group viruses.	Polysaccharides	162-168	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	190-193
30355496-7	2018	Thus, completely glycan-shielded viruses were associated with accelerated neutralization breadth development, suggesting that Env immunogens with intact glycan shields may be preferred components of AIDS vaccines.	Polysaccharides	17-23	endogenous retrovirus group K member 20	Homo sapiens	126-129
30332789-9	2018	Investigation of the K66 protein binding to cells and different polysaccharides implies the beta-1,6 glucans to be the primary receptors of S. paradoxus K66 toxin.	Polysaccharides	64-79	hemoglobin, beta adult major chain	Mus musculus	92-100
30961093-4	2018	The swelling ratio of the CNC-g-AA aerogels was as high as 495:1, which is considerably greater than that of other polysaccharide-g-AA aerogels systems.	Polysaccharides	115-129	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	26-31
30332800-1	2018	2,3-O-acetylated-1,4-beta-d-glucomannan (DOP-1-1) is a polysaccharide isolated from the stem of Dendrobium officinale.	Polysaccharides	55-69	DOP1 leucine zipper like protein A	Homo sapiens	41-48
30009896-1	2018	In this work, a green strategy is performed to fabricate Pd3Ag nanoparticles (NPs) using plant-extracted polysaccharide (Lilium brownie polysaccharide, LBP).	Polysaccharides	105-119	lipopolysaccharide binding protein	Homo sapiens	152-155
29920367-2	2018	In this work, a polysaccharide fraction (GLP) was purified from G. lucidum by water extraction and alcohol precipitation.	Polysaccharides	16-30	euchromatic histone lysine methyltransferase 1	Homo sapiens	41-44
30302011-8	2018	These results present key, previously overlooked, considerations for HIV-1 Env glycan research and related vaccine studies.	Polysaccharides	79-85	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	75-78
30170361-4	2018	In this study, Se-enriched Astragalus polysaccharide nanoparticles (Se-APS) were prepared by the previous optimization experimental conditions, as follows: reaction temperature 80.5  C, pH 7.8, ratio of catalyst to APS 0.57:1.0 g g-1, and reaction time 62 min.	Polysaccharides	38-52	SH2B adaptor protein 2	Homo sapiens	71-74
30170361-4	2018	In this study, Se-enriched Astragalus polysaccharide nanoparticles (Se-APS) were prepared by the previous optimization experimental conditions, as follows: reaction temperature 80.5  C, pH 7.8, ratio of catalyst to APS 0.57:1.0 g g-1, and reaction time 62 min.	Polysaccharides	38-52	SH2B adaptor protein 2	Homo sapiens	215-218
30030077-0	2018	Polysaccharides from Dendrobium officinale inhibit bleomycin-induced pulmonary fibrosis via the TGFbeta1-Smad2/3 axis.	Polysaccharides	0-15	transforming growth factor, beta 1	Rattus norvegicus	96-104
30030077-0	2018	Polysaccharides from Dendrobium officinale inhibit bleomycin-induced pulmonary fibrosis via the TGFbeta1-Smad2/3 axis.	Polysaccharides	0-15	SMAD family member 2	Rattus norvegicus	105-110
30007625-4	2018	Significant DNA damage and caspase-3 activation could be detected in lens epithelial cell cultures exposed to CN made from highly deacetylated polysaccharides, indicating apoptosis-related cytotoxicity due to relatively high positive charge density of the graft copolymers.	Polysaccharides	143-158	caspase-3	Oryctolagus cuniculus	27-36
30296390-4	2018	Finally, mucin glycans are critical for regulating microbial interactions, serving as receptor binding sites for adhesion, as nutrient sources, and as environmental signals.	Polysaccharides	15-22	LOC100508689	Homo sapiens	9-14
29981898-5	2018	Using an off-line HPLC-MALDI-TOF-MS approach combined with exoglycosidase digestions and MS/MS, we reveal that the multiple hexose residues of the N-glycans of the gly-12;gly-13;gly-14 triple mutant are not just mannose, but include galactoses in three different positions (beta-intersecting, beta-bisecting and alpha-terminal) on isomeric forms of Hex4-8HexNAc2 structures; some of these structures are fucosylated and/or methylated.	Polysaccharides	149-156	GLYcosylation related	Caenorhabditis elegans	164-170
29981898-5	2018	Using an off-line HPLC-MALDI-TOF-MS approach combined with exoglycosidase digestions and MS/MS, we reveal that the multiple hexose residues of the N-glycans of the gly-12;gly-13;gly-14 triple mutant are not just mannose, but include galactoses in three different positions (beta-intersecting, beta-bisecting and alpha-terminal) on isomeric forms of Hex4-8HexNAc2 structures; some of these structures are fucosylated and/or methylated.	Polysaccharides	149-156	Putative alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Caenorhabditis elegans	171-177
29981898-5	2018	Using an off-line HPLC-MALDI-TOF-MS approach combined with exoglycosidase digestions and MS/MS, we reveal that the multiple hexose residues of the N-glycans of the gly-12;gly-13;gly-14 triple mutant are not just mannose, but include galactoses in three different positions (beta-intersecting, beta-bisecting and alpha-terminal) on isomeric forms of Hex4-8HexNAc2 structures; some of these structures are fucosylated and/or methylated.	Polysaccharides	149-156	GLYcosylation related	Caenorhabditis elegans	178-184
30249497-1	2018	The receptor for hyaluronan mediated motility (RHAMM, gene name HMMR) belongs to a group of proteins that bind to hyaluronan (HA), a high-molecular weight anionic polysaccharide that has pro-angiogenic and inflammatory properties when fragmented.	Polysaccharides	163-177	hyaluronan mediated motility receptor	Homo sapiens	4-45
30249497-1	2018	The receptor for hyaluronan mediated motility (RHAMM, gene name HMMR) belongs to a group of proteins that bind to hyaluronan (HA), a high-molecular weight anionic polysaccharide that has pro-angiogenic and inflammatory properties when fragmented.	Polysaccharides	163-177	hyaluronan mediated motility receptor	Homo sapiens	47-52
30249497-1	2018	The receptor for hyaluronan mediated motility (RHAMM, gene name HMMR) belongs to a group of proteins that bind to hyaluronan (HA), a high-molecular weight anionic polysaccharide that has pro-angiogenic and inflammatory properties when fragmented.	Polysaccharides	163-177	hyaluronan mediated motility receptor	Homo sapiens	64-68
30007645-0	2018	Discovery of a polysaccharide from the fruiting bodies of Lepista sordida as potent inhibitors of indoleamine 2, 3-dioxygenase (IDO) in HepG2 cells via blocking of STAT1-mediated JAK-PKC-delta signaling pathways.	Polysaccharides	15-29	indoleamine 2,3-dioxygenase 1	Homo sapiens	128-131
30007645-0	2018	Discovery of a polysaccharide from the fruiting bodies of Lepista sordida as potent inhibitors of indoleamine 2, 3-dioxygenase (IDO) in HepG2 cells via blocking of STAT1-mediated JAK-PKC-delta signaling pathways.	Polysaccharides	15-29	signal transducer and activator of transcription 1	Homo sapiens	164-169
30007645-0	2018	Discovery of a polysaccharide from the fruiting bodies of Lepista sordida as potent inhibitors of indoleamine 2, 3-dioxygenase (IDO) in HepG2 cells via blocking of STAT1-mediated JAK-PKC-delta signaling pathways.	Polysaccharides	15-29	protein kinase C delta	Homo sapiens	183-192
30007645-1	2018	The present study examined the role of a polysaccharide (LSP, 25 and 100 mug/ml) from the fruiting bodies of Lepista sordid on the immunosuppressive enzyme indoleamine 2, 3-dioxygenase (IDO) in HepG2 cells, and the possible mechanism of action.	Polysaccharides	41-55	indoleamine 2,3-dioxygenase 1	Homo sapiens	186-189
30176279-1	2018	Human hyaluronidase-1 (Hyal-1) is one of the main enzymes in the homeostasis of hyaluronic acid (HA), the main polysaccharide of extracellular matrix.	Polysaccharides	111-125	hyaluronidase 1	Homo sapiens	6-21
29753267-8	2018	Thus overall the binding of IL-12 via its p40 subunit to heparin-related polysaccharides of the extracellular matrix appears to be functionally important since it has been conserved across mammalian species despite this structural divergence.	Polysaccharides	73-88	interleukin 9	Homo sapiens	42-45
28790160-13	2018	A polysaccharide-enriched diet counteracted the ecological advantage of C. rodentium and the defective pathogen-specific antibody response in Card9-/- mice.	Polysaccharides	2-16	caspase recruitment domain family, member 9	Mus musculus	142-147
30133879-6	2018	We also found that CWH43 is genetically related to TED1, which encodes a protein involved in the removal of the ethanolamine phosphate from the second mannose residue in GPI glycan moieties.	Polysaccharides	174-180	Cwh43p	Saccharomyces cerevisiae S288C	19-24
30133879-6	2018	We also found that CWH43 is genetically related to TED1, which encodes a protein involved in the removal of the ethanolamine phosphate from the second mannose residue in GPI glycan moieties.	Polysaccharides	174-180	Ted1p	Saccharomyces cerevisiae S288C	51-55
29924315-7	2018	Glycan array studies demonstrated Siglec-8 binding to synthetic glycans with a terminal Neu5Acalpha2-3(6-sulfo)-Gal determinant, a quantitatively minor terminus on keratan sulfate (KS) chains of aggrecan.	Polysaccharides	0-6	sialic acid binding Ig like lectin 8	Homo sapiens	34-42
29924315-7	2018	Glycan array studies demonstrated Siglec-8 binding to synthetic glycans with a terminal Neu5Acalpha2-3(6-sulfo)-Gal determinant, a quantitatively minor terminus on keratan sulfate (KS) chains of aggrecan.	Polysaccharides	64-71	sialic acid binding Ig like lectin 8	Homo sapiens	34-42
30194503-6	2018	We found that the levels of trisialylated triantennary glycans of haptoglobin and vitamin D-binding protein increased significantly as the disease progressed, while the alteration in these protein levels were modest.	Polysaccharides	55-62	haptoglobin	Mus musculus	66-77
29982679-2	2018	It contains several glycan binding sites which mediate recognition of alpha2-3-linked sialic acid (FH domain 20) and glycosaminoglycans (domains 6-8 and 19-20).	Polysaccharides	20-26	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	70-78
29792965-2	2018	In this study, a novel polysaccharide (MDP1) with a molecular weight of 139.54 kDa was isolated from Millettia dielsiana by DEAE-52 cellulose chromatography.	Polysaccharides	23-37	magnesium-dependent phosphatase 1	Mus musculus	39-43
29802924-8	2018	These data demonstrated that the polysaccharide RRP1 could be developed as a promising candidate for preventing and treating liver damage induced by toxic chemicals.	Polysaccharides	33-47	ribosomal RNA processing 1	Mus musculus	48-52
29842952-0	2018	Structural characterization and alpha-glucosidase inhibitory activity of polysaccharides extracted from Chinese traditional medicine Huidouba.	Polysaccharides	73-88	sucrase-isomaltase	Homo sapiens	32-49
29792965-4	2018	Structural analysis indicated that MDP1 was a pectic polysaccharide and did not exhibit a triple helical conformation.	Polysaccharides	53-67	magnesium-dependent phosphatase 1	Mus musculus	35-39
29802924-1	2018	In this study, two polysaccharide fractions (RRP1: Mw = 5.5 kDa, and RRP2: Mw = 425.7 kDa) were isolated from Rhodiola rosea to investigate their antioxidation and hepatoprotective effects.	Polysaccharides	19-33	ribosomal RNA processing 1	Mus musculus	45-49
29509998-3	2018	Mannose-binding lectins surfactant protein D (SP-D), cyanovirin-N (CV-N) and human mannose-binding lectin (hMBL) also induce salicylic acid (SA)-dependent HR-like cell death in N. benthamiana, and this effect is mediated by the lectin"s glycan binding activity.	Polysaccharides	237-243	surfactant protein D	Homo sapiens	46-50
29509998-3	2018	Mannose-binding lectins surfactant protein D (SP-D), cyanovirin-N (CV-N) and human mannose-binding lectin (hMBL) also induce salicylic acid (SA)-dependent HR-like cell death in N. benthamiana, and this effect is mediated by the lectin"s glycan binding activity.	Polysaccharides	237-243	mannose binding lectin 2	Homo sapiens	83-105
30093410-2	2018	Our mRNA transcript analyses on the genes involved in synthesizing GlcNAc-6-O-sulfated glycans in human colon cancer tissues indicated that GlcNAc6ST-2 (CHST4) is preferentially expressed in cancer cells compared with nonmalignant epithelial cells among the three known major GlcNAc-6-O-sulfotransferases.	Polysaccharides	87-94	carbohydrate sulfotransferase 4	Homo sapiens	140-151
30093410-2	2018	Our mRNA transcript analyses on the genes involved in synthesizing GlcNAc-6-O-sulfated glycans in human colon cancer tissues indicated that GlcNAc6ST-2 (CHST4) is preferentially expressed in cancer cells compared with nonmalignant epithelial cells among the three known major GlcNAc-6-O-sulfotransferases.	Polysaccharides	87-94	carbohydrate sulfotransferase 4	Homo sapiens	153-158
30115684-1	2018	The glycan shield on the envelope glycoprotein gp120 of HIV-1 has drawn immense attention as a vulnerable site for broadly neutralizing antibodies and for its significant impact on host adaptive immune response to HIV-1.	Polysaccharides	4-10	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	47-52
30115684-2	2018	Glycosylation sites and glycan composition/structure at each site on gp120 along with the interactions of gp120 glycan shield with broadly neutralizing antibodies have been extensively studied.	Polysaccharides	24-30	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	69-74
30093410-7	2018	In contrast, GlcNAc6ST-2 could efficiently add sulfate onto both extended core 1- and core 2-based O-glycans, leading to the production of unique sulfated extended core 1 structures such as R-GlcNAc(6-SO3 -)beta1-3Galbeta1-4GlcNAc(6-SO3 -)beta1-3Galbeta1-3GalNAcalpha, which are good candidates to be targeted as cancer-specific glycans.	Polysaccharides	101-108	carbohydrate sulfotransferase 4	Homo sapiens	13-24
30115684-2	2018	Glycosylation sites and glycan composition/structure at each site on gp120 along with the interactions of gp120 glycan shield with broadly neutralizing antibodies have been extensively studied.	Polysaccharides	112-118	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	106-111
30115684-3	2018	However, a method for directly and selectively tracking gp120 glycans has been lacking.	Polysaccharides	62-69	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	56-61
30344930-7	2018	Treatment of MYCN-non-amplified cells with Trichostatin A (TSA), an histone deacetylase inhibitor, increased the expression of Lewis glycans and the enzymes involved in their biosynthesis.	Polysaccharides	133-140	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	13-17
30115684-4	2018	Here, we integrate metabolic labeling and click chemistry technology with recombinant gp120 expression to demonstrate that gp120 glycans could be specifically labeled and directly detected.	Polysaccharides	129-136	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	86-91
30115684-4	2018	Here, we integrate metabolic labeling and click chemistry technology with recombinant gp120 expression to demonstrate that gp120 glycans could be specifically labeled and directly detected.	Polysaccharides	129-136	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	123-128
30115684-5	2018	Selective labeling of gp120 by N-azidoacetylmannosamine (ManNAz) and N-azidoacetylgalactosamine (GalNAz) incorporation into the gp120 glycan shield was characterized by MS of tryptic glycopeptides.	Polysaccharides	134-140	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	22-27
30115684-5	2018	Selective labeling of gp120 by N-azidoacetylmannosamine (ManNAz) and N-azidoacetylgalactosamine (GalNAz) incorporation into the gp120 glycan shield was characterized by MS of tryptic glycopeptides.	Polysaccharides	134-140	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	128-133
30115684-7	2018	Collectively, our data reveal an effective labeling and detection method for gp120, serving as a tool for functional characterization of the gp120 glycans and potentially other glycosylated proteins.	Polysaccharides	147-154	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	77-82
30115684-7	2018	Collectively, our data reveal an effective labeling and detection method for gp120, serving as a tool for functional characterization of the gp120 glycans and potentially other glycosylated proteins.	Polysaccharides	147-154	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	141-146
30156827-4	2018	As hyaluronan (HA) is an anionic polysaccharide that is widely used for specific binding to CD44 to improve the cellular uptake efficiency in tumor-targeting therapy, in this study, we modified cationic liposomes (LP) with the negatively charged HA at a mass ratio of 10% to prepare targeted HA-modified cationic liposomes (HALP).	Polysaccharides	33-47	CD44 antigen	Mus musculus	92-96
30250045-10	2018	The specific detection of mesothelioma with SKM9-2 can thus be performed by the recognition of sialylated glycan modification in the specific region of HEG1.	Polysaccharides	106-112	heart development protein with EGF like domains 1	Homo sapiens	152-156
30344930-3	2018	In this work we characterized the glycophenotype and the enzyme expression involved in glycans biosynthesis in five established human NB cell lines and in patient-derived primary tumors with different MYCN status.	Polysaccharides	87-94	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	201-205
30344930-6	2018	Silencing of C2GNT1 expression in NB cells diminished expression of Lewis glycans, decreased the E- and P-selectin binding, and reduced cell adhesion, migration and proliferation in vitro.	Polysaccharides	74-81	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	13-19
30344930-8	2018	Our results demonstrate that MYCN-amplified NB cells overexpress Lewis family glycans, which belong to the Core 2 O-glycans group.	Polysaccharides	78-85	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	29-33
30144161-4	2018	O-linked glycans and phosphate variants of the tau protein-derived VQIVYK hexapeptide motif were generated as a simplified amyloid scaffold model and demonstrate that, while self-aggregation can be attenuated by either a single glycan or a phosphate unit, only co-incubation with the O-GlcNAc variant inhibits aggregation of the native peptide.	Polysaccharides	9-15	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	284-292
30279687-8	2018	Collectively, our findings support FIBCD1 as a human lung epithelial pattern recognition receptor that recognizes the complex A. fumigatus cell wall polysaccharides and modulates the lung epithelial inflammatory response by suppressing inflammatory mediators and mucins.	Polysaccharides	149-164	fibrinogen C domain containing 1	Homo sapiens	35-41
30294329-5	2018	ST6Gal-1 is a sialyltransferase that constructs the alpha2,6-sialyl linkage on cell surface and extracellular glycans.	Polysaccharides	110-117	beta galactoside alpha 2,6 sialyltransferase 1	Mus musculus	0-8
30231941-9	2018	In CG patients (males and females analysed as one group), the key glycan synthesis modifier genes MGAT3 and FUT8, which influence glycan chain bisecting and fucosylation and subsequent cell signalling and adhesion, were found to be significantly upregulated (p &lt; 0.01 and p &lt; 0.05) and also the glycan synthesis gene ALG9 (p &lt; 0.01).	Polysaccharides	66-72	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	98-103
30231941-9	2018	In CG patients (males and females analysed as one group), the key glycan synthesis modifier genes MGAT3 and FUT8, which influence glycan chain bisecting and fucosylation and subsequent cell signalling and adhesion, were found to be significantly upregulated (p &lt; 0.01 and p &lt; 0.05) and also the glycan synthesis gene ALG9 (p &lt; 0.01).	Polysaccharides	66-72	fucosyltransferase 8	Homo sapiens	108-112
30231941-9	2018	In CG patients (males and females analysed as one group), the key glycan synthesis modifier genes MGAT3 and FUT8, which influence glycan chain bisecting and fucosylation and subsequent cell signalling and adhesion, were found to be significantly upregulated (p &lt; 0.01 and p &lt; 0.05) and also the glycan synthesis gene ALG9 (p &lt; 0.01).	Polysaccharides	66-72	ALG9 alpha-1,2-mannosyltransferase	Homo sapiens	323-327
30231941-9	2018	In CG patients (males and females analysed as one group), the key glycan synthesis modifier genes MGAT3 and FUT8, which influence glycan chain bisecting and fucosylation and subsequent cell signalling and adhesion, were found to be significantly upregulated (p &lt; 0.01 and p &lt; 0.05) and also the glycan synthesis gene ALG9 (p &lt; 0.01).	Polysaccharides	130-136	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	98-103
30231941-9	2018	In CG patients (males and females analysed as one group), the key glycan synthesis modifier genes MGAT3 and FUT8, which influence glycan chain bisecting and fucosylation and subsequent cell signalling and adhesion, were found to be significantly upregulated (p &lt; 0.01 and p &lt; 0.05) and also the glycan synthesis gene ALG9 (p &lt; 0.01).	Polysaccharides	130-136	fucosyltransferase 8	Homo sapiens	108-112
30231941-9	2018	In CG patients (males and females analysed as one group), the key glycan synthesis modifier genes MGAT3 and FUT8, which influence glycan chain bisecting and fucosylation and subsequent cell signalling and adhesion, were found to be significantly upregulated (p &lt; 0.01 and p &lt; 0.05) and also the glycan synthesis gene ALG9 (p &lt; 0.01).	Polysaccharides	130-136	ALG9 alpha-1,2-mannosyltransferase	Homo sapiens	323-327
30231941-9	2018	In CG patients (males and females analysed as one group), the key glycan synthesis modifier genes MGAT3 and FUT8, which influence glycan chain bisecting and fucosylation and subsequent cell signalling and adhesion, were found to be significantly upregulated (p &lt; 0.01 and p &lt; 0.05) and also the glycan synthesis gene ALG9 (p &lt; 0.01).	Polysaccharides	130-136	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	98-103
30231941-9	2018	In CG patients (males and females analysed as one group), the key glycan synthesis modifier genes MGAT3 and FUT8, which influence glycan chain bisecting and fucosylation and subsequent cell signalling and adhesion, were found to be significantly upregulated (p &lt; 0.01 and p &lt; 0.05) and also the glycan synthesis gene ALG9 (p &lt; 0.01).	Polysaccharides	130-136	fucosyltransferase 8	Homo sapiens	108-112
30231941-9	2018	In CG patients (males and females analysed as one group), the key glycan synthesis modifier genes MGAT3 and FUT8, which influence glycan chain bisecting and fucosylation and subsequent cell signalling and adhesion, were found to be significantly upregulated (p &lt; 0.01 and p &lt; 0.05) and also the glycan synthesis gene ALG9 (p &lt; 0.01).	Polysaccharides	130-136	ALG9 alpha-1,2-mannosyltransferase	Homo sapiens	323-327
30236114-11	2018	CONCLUSIONS: The results of this study reveal the relation between the linker structure, glycan distribution and the affinity of the glycopolymer nanomaterial to Gal-3.	Polysaccharides	89-95	galectin 3	Homo sapiens	162-167
30148596-3	2018	Herein, we report that Shiitake-derived polysaccharide lentinan manipulates in vitro hIAPP fibrillation and modulates IAPP-induced cytotoxicity in a conformation-dependent manner.	Polysaccharides	40-54	islet amyloid polypeptide	Homo sapiens	86-90
30148596-7	2018	To the best of our knowledge, this is the first time to report a conformation-dependent inhibition of hIAPP aggregation, which will provide new insights for our understanding of the manipulation mechanisms on hIAPP by natural polysaccharides and open a new avenue for designing and screening potential amyloid inhibitors against type 2 diabetes.	Polysaccharides	226-241	islet amyloid polypeptide	Homo sapiens	102-107
30148596-7	2018	To the best of our knowledge, this is the first time to report a conformation-dependent inhibition of hIAPP aggregation, which will provide new insights for our understanding of the manipulation mechanisms on hIAPP by natural polysaccharides and open a new avenue for designing and screening potential amyloid inhibitors against type 2 diabetes.	Polysaccharides	226-241	islet amyloid polypeptide	Homo sapiens	209-214
30122633-0	2018	Glycan-Independent Gamete Recognition Triggers Egg Zinc Sparks and ZP2 Cleavage to Prevent Polyspermy.	Polysaccharides	0-6	zona pellucida glycoprotein 2	Mus musculus	67-70
30181292-11	2018	Receptor-induced long-distance conformational transitions have important implications for the interaction of aberrantly glycosylated IgA1 with anti-glycan autoantibodies in IgA nephropathy.	Polysaccharides	148-154	immunoglobulin heavy constant alpha 1	Homo sapiens	133-137
29891277-2	2018	In our previous study, we isolated a water-soluble polysaccharide (BCPS) from Bupleurum chinense and showed that it exhibits anti-inflammatory effect by antagonizing P-selectin-mediated adhesion of HL-60 cells to CHO-P cells.	Polysaccharides	51-65	selectin P	Homo sapiens	166-176
29891307-1	2018	A novel water-soluble polysaccharide (named ALP-1) was successfully isolated from the stem barks of Acanthopanax leucorrhizus by hot-water extraction, and further purified by Cellulose DEAE-52 and Sephadex G-100 chromatography.	Polysaccharides	22-36	asparaginase and isoaspartyl peptidase 1	Homo sapiens	44-49
30021899-8	2018	In fact, gp120/gp140-specific antibody functional correlates between antibody-dependent cellular cytotoxicity, antibody-dependent phagocytosis, and ADCML as well as the gp120-specific IgG glycan profiles and the corresponding ADCML correlations varied depending on the sex of the vaccinees.	Polysaccharides	188-194	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	169-174
30338216-7	2018	Previously performed untargeted nano-high-performance liquid chromatography-chip/time-of-flight mass spectrometry was used to detect and quantify glycans originating from colonic mucin.	Polysaccharides	146-153	LOC100508689	Homo sapiens	179-184
30338216-8	2018	Colonic mucin-derived O-glycans from control infants composed 37.68% (+- 3.14% SD) of the total glycan structure pool, whereas colonic mucin-derived O-glycans made up of only 1.78% (+- 0.038% SD) of the total in B. infantis EVC001 samples.	Polysaccharides	24-30	LOC100508689	Homo sapiens	8-13
30338216-9	2018	The relative abundance of these colonic mucin-derived O-glycans in the total glycan pool was higher among control, 26.98% (+- 8.48% SD), relative to B. infantis-colonized infants, 1.68% (+- 1.12% SD).	Polysaccharides	56-62	LOC100508689	Homo sapiens	40-45
29844132-7	2018	GALNT6 silencing in SW480 cells promoted invasion, migration, chemoresistance, and increased cell surface expression of a cancer-associated truncated O-glycan, Tn-antigen.Conclusions: The 15-glycogene signature and the expression levels of GALNT6 mRNA and protein each serve as a novel prognostic biomarker, highlighting the role of dysregulated glycogenes in cancer-associated glycan synthesis and poor prognosis.	Polysaccharides	152-158	polypeptide N-acetylgalactosaminyltransferase 6	Homo sapiens	0-6
29885470-8	2018	The 1-amino-alditols were also permethylated to form quaternary ammonium cations at the reducing end, which enhance the MS sensitivity and are compatible with sequential multi-stage mass spectrometry (MSn) fragmentation for glycan sequencing.	Polysaccharides	224-230	moesin	Homo sapiens	201-204
30174180-4	2018	Whereas HA is normally synthesized bilaterally as a simple polysaccharide, we show that covalent modification of HA by the enzyme Tsg6 on the right triggers distinct cell behavior necessary to drive the conserved midgut rotation and to pattern gut vasculature.	Polysaccharides	59-73	tumor necrosis factor alpha induced protein 6	Mus musculus	130-134
30177768-4	2018	To this end, we developed synthetic gene circuits to control E. coli MG1655 biofilm formation by using CRISPRi/dCas9 to regulate a gene (wcaF) involved in the synthesis of colanic acid (CA), a key polysaccharide in E. coli biofilm extracellular polymeric substance (EPS).	Polysaccharides	197-211	colanic acid biosynthesis acetyltransferase WcaF	Escherichia coli str. K-12 substr. MG1655	137-141
30021839-2	2018	However, recent studies have demonstrated that EDEM1 binds to some misfolded proteins in a glycan-independent manner, suggesting a more complex binding landscape for EDEM1.	Polysaccharides	91-97	ER degradation enhancing alpha-mannosidase like protein 1	Homo sapiens	47-52
30021839-6	2018	Moreover, a protein construct comprising the EDEM1 MLD had thiol-dependent binding properties along with its active glycan-trimming activities.	Polysaccharides	116-122	ER degradation enhancing alpha-mannosidase like protein 1	Homo sapiens	45-50
29370379-0	2018	Glycan-directed CAR-T cells.	Polysaccharides	0-6	nuclear receptor subfamily 1, group I, member 3	Mus musculus	16-19
30269844-10	2018	Kv1.1 mRNA and protein expressions were increased (P &lt; 0.05) after polysaccharide extract treatment in polyamine-deficient IEC-6 cells and RhoA protein expression was increased.	Polysaccharides	70-84	potassium voltage-gated channel subfamily A member 1	Rattus norvegicus	0-5
29777742-1	2018	BACKGROUND: The glycan moieties sialyl-Lewis-X and/or -A (sLeX/A) are the primary ligands for E-selectin, regulating subsequent tumor cell extravasation into distant organs.	Polysaccharides	16-22	selectin E	Homo sapiens	94-104
29753871-1	2018	This study investigated the possible protective effect of combined fungal polysaccharides (CFP), consisting of Cordyceps sinensis polysaccharides (CSP) and Ganoderma atrum polysaccharides (PSG) with well-defined structural characteristics, against cyclophosphamide (CTX)-induced hepatotoxicity in mice.	Polysaccharides	74-89	pregnancy specific glycoprotein 16	Mus musculus	189-192
29370379-7	2018	Here, we discuss the field of glycan-directed CAR-T cells and review the different classes of antibodies specific for glycan-targeting, including the generation of high affinity O-glycopeptide antibodies.	Polysaccharides	30-36	nuclear receptor subfamily 1, group I, member 3	Mus musculus	46-49
29370379-8	2018	Finally, we discuss historic and recently investigated glycan targets for CAR-T cells and provide our perspective on how targeting the tumor glycoproteome and/or glycome will improve CAR-T immunotherapy.	Polysaccharides	55-61	nuclear receptor subfamily 1, group I, member 3	Mus musculus	74-77
30101537-3	2018	In the present study, we aimed to reconstitute the ischemic induction of AAV9 in vivo, using local injection of histamine (to increase vascular permeability) and neuraminidase (to desialylate cell surface glycans).	Polysaccharides	205-212	neuraminidase 1	Homo sapiens	123-175
29777809-2	2018	Monosaccharide composition analysis revealed that all the polysaccharides primarily contained Man, GlcA, GalA, Glc, Gal, Xyl, Ara and Fuc.	Polysaccharides	58-73	galactosidase alpha	Homo sapiens	105-109
29633346-7	2018	Finally, levels of certain circulating anti-inflammatory glycans are associated with higher levels of CD4 T cells and lower levels of T-cell activation.	Polysaccharides	57-64	CD4 molecule	Homo sapiens	102-105
29775715-5	2018	Polysaccharide molecules obtained using Cellic CTec2 enzyme induced RAW264.7 murine macrophage cells to release considerable amount of inflammatory mediators including nitric oxide, IL-1beta, TNF-alpha, IL-6 and IL-10.	Polysaccharides	0-14	interleukin 1 beta	Mus musculus	182-190
29775715-5	2018	Polysaccharide molecules obtained using Cellic CTec2 enzyme induced RAW264.7 murine macrophage cells to release considerable amount of inflammatory mediators including nitric oxide, IL-1beta, TNF-alpha, IL-6 and IL-10.	Polysaccharides	0-14	tumor necrosis factor	Mus musculus	192-201
29775715-5	2018	Polysaccharide molecules obtained using Cellic CTec2 enzyme induced RAW264.7 murine macrophage cells to release considerable amount of inflammatory mediators including nitric oxide, IL-1beta, TNF-alpha, IL-6 and IL-10.	Polysaccharides	0-14	interleukin 6	Mus musculus	203-207
29775715-5	2018	Polysaccharide molecules obtained using Cellic CTec2 enzyme induced RAW264.7 murine macrophage cells to release considerable amount of inflammatory mediators including nitric oxide, IL-1beta, TNF-alpha, IL-6 and IL-10.	Polysaccharides	0-14	interleukin 10	Mus musculus	212-217
29701803-6	2018	CSF proteins of 34 iNPH and 15 non-iNPH patients were analysed by Western blotting, revealing two glycan isoforms of transferrin (Tf); "brain-type" Tf with N-acetylglucosaminylated glycans and "serum-type" Tf with alpha2, 6-sialylated glycans.	Polysaccharides	98-104	transferrin	Homo sapiens	117-128
29678737-3	2018	However, rHSA often entraps endogenous or exogenous impurities, including color pigments and polysaccharides.	Polysaccharides	93-108	CD24 molecule	Rattus norvegicus	9-13
30051805-9	2018	The mean protein concentration was 0.585+-0.29 mg ml-1 and the mean polysaccharide concentration was 0.054+-0.03 mg ml-1.	Polysaccharides	68-82	interleukin 17F	Homo sapiens	116-120
29678737-8	2018	Through this procedure, the pigment content (A350/A280) and polysaccharides content of rHSA were reduced to 0.0141 and 0.253 mug/mg, respectively, which were comparable to pHSA.	Polysaccharides	60-75	CD24 molecule	Rattus norvegicus	87-91
29655744-3	2018	This study aimed to examine the in vivo immunomodulatory activity of two acidic polysaccharides, HP1 and HP2, extracted and purified from Zizyphus jujuba cv.	Polysaccharides	80-95	chromobox 5	Mus musculus	97-100
30066937-0	2018	Effects of aloe polysaccharide, a polysaccharide extracted from Aloe vera, on TNF-alpha-induced HaCaT cell proliferation and the underlying mechanism in psoriasis.	Polysaccharides	16-30	tumor necrosis factor	Homo sapiens	78-87
30157178-8	2018	Monomeric gp120s produced in the MGAT1- CHO cell line exhibit improved binding to prototypic glycan-dependent bN-mAbs directed to the V1/V2 domain (e.g., PG9) and the V3 stem (e.g., PGT128 and 10-1074) while preserving the structure of the important glycan-independent epitopes (e.g., VRC01).	Polysaccharides	93-99	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Cricetulus griseus	33-38
30157178-8	2018	Monomeric gp120s produced in the MGAT1- CHO cell line exhibit improved binding to prototypic glycan-dependent bN-mAbs directed to the V1/V2 domain (e.g., PG9) and the V3 stem (e.g., PGT128 and 10-1074) while preserving the structure of the important glycan-independent epitopes (e.g., VRC01).	Polysaccharides	250-256	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Cricetulus griseus	33-38
30134158-1	2018	Many broadly neutralizing antibodies (bnAbs) against HIV-1 recognize and/or penetrate the glycan shield on native, virion-associated envelope glycoprotein (Env) spikes.	Polysaccharides	90-96	endogenous retrovirus group K member 20	Homo sapiens	133-154
30033944-11	2018	Synthesized branched sialylated glycan clusters interacted with sialic acid-binding immunoglobulin-like lectin H (Siglec-H), which is known to be a microglia-specific molecule.	Polysaccharides	32-38	sialic acid binding Ig-like lectin H	Mus musculus	64-112
30033944-11	2018	Synthesized branched sialylated glycan clusters interacted with sialic acid-binding immunoglobulin-like lectin H (Siglec-H), which is known to be a microglia-specific molecule.	Polysaccharides	32-38	sialic acid binding Ig-like lectin H	Mus musculus	114-122
30140003-7	2018	In addition, interaction of the substrate N-glycoprotein with GnT-V likely contributes to protein-selective and site-specific glycan modification.	Polysaccharides	126-132	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	62-67
30091436-4	2018	Herein, this study aims to investigate the immunoregulatory role of 2-N,6-O-sulfated chitosan (26SCS), a sulfated polysaccharide, in the osteogenetic capacity of BMP-2 and the subsequent effects on bone regeneration.	Polysaccharides	114-128	bone morphogenetic protein 2	Homo sapiens	162-167
29604134-1	2018	Analysis of non-Gal antibody induced after pig-to-baboon cardiac xenotransplantation identified the glycan produced by porcine beta-1,4-N-acetyl-galactosaminyltransferase 2 (B4GALNT2) as an immunogenic xenotransplantation antigen.	Polysaccharides	100-106	beta-1,4 N-acetylgalactosaminyltransferase 2	Papio anubis	127-172
29604134-1	2018	Analysis of non-Gal antibody induced after pig-to-baboon cardiac xenotransplantation identified the glycan produced by porcine beta-1,4-N-acetyl-galactosaminyltransferase 2 (B4GALNT2) as an immunogenic xenotransplantation antigen.	Polysaccharides	100-106	beta-1,4 N-acetylgalactosaminyltransferase 2	Papio anubis	174-182
30134158-1	2018	Many broadly neutralizing antibodies (bnAbs) against HIV-1 recognize and/or penetrate the glycan shield on native, virion-associated envelope glycoprotein (Env) spikes.	Polysaccharides	90-96	endogenous retrovirus group K member 20	Homo sapiens	156-159
30134158-6	2018	Glycans relevant to key bnAb epitopes are generally similar on the recombinant SOSIP and virion-derived Env proteins, although the latter do contain hotspots of elevated glycan processing.	Polysaccharides	0-7	endogenous retrovirus group K member 20	Homo sapiens	104-107
30131559-6	2018	The classification distinguishes EPO variants with varying levels of glycan branchingand sialylation, which are crucial parameters in biotherapeutic efficacy.	Polysaccharides	69-75	erythropoietin	Homo sapiens	33-36
30076101-0	2018	Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies.	Polysaccharides	0-6	CD4 molecule	Homo sapiens	53-56
30076101-5	2018	Compared to the parental eOD-GT8, a mutant with five added glycans stimulated significantly higher proportions of CD4bs-specific serum responses and CD4bs-specific immunoglobulin G+ B cells including VRC01-class precursors.	Polysaccharides	59-66	CD4 molecule	Homo sapiens	114-117
29967067-1	2018	N-acetylphosphoglucosamine mutase (AGM1) is a key component of the hexosamine biosynthetic pathway that produces UDP-GlcNAc, an essential precursor for a wide range of glycans in eukaryotes.	Polysaccharides	168-175	phosphoglucomutase 3	Homo sapiens	35-39
29903935-1	2018	Changes in mucin-type O-linked glycosylation are seen in over 90% of breast cancers where increased sialylation is often observed and a change from branched glycans to linear glycans is often seen.	Polysaccharides	157-164	LOC100508689	Homo sapiens	11-16
29903935-1	2018	Changes in mucin-type O-linked glycosylation are seen in over 90% of breast cancers where increased sialylation is often observed and a change from branched glycans to linear glycans is often seen.	Polysaccharides	175-182	LOC100508689	Homo sapiens	11-16
30138408-7	2018	The two groups of mAbs (glycan cap versus stem) demonstrated very different profiles of activities suggesting usage of mAbs with different epitope specificity could coordinate inhibition of multiple steps of filovirus infection through Fab- and Fc-mediated mechanisms, and provide a reliable therapeutic approach.	Polysaccharides	24-30	FA complementation group B	Homo sapiens	236-239
30049713-5	2018	Targeting surface-expressed PHBs on Th17 cells with ligands such as Vi polysaccharide (Typhim vaccine) inhibited CRAF-MAPK pathway, reduced interleukin (IL)-17 expression and ameliorated disease pathology with an increase in FOXP3+-expressing Tregs in an animal model for multiple sclerosis (MS).	Polysaccharides	71-85	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	113-117
29801851-0	2018	The mechanisms of sulfated polysaccharide drug of propylene glycol alginate sodium sulfate (PSS) on bleeding side effect.	Polysaccharides	27-41	PSS	Homo sapiens	92-95
29801851-1	2018	Propylene glycol alginate sodium sulfate (PSS), a sulfated polysaccharide derivative, has been used as a heparinoid drug to prevent and treat hyperlipidemia and ischemic cardio-cerebrovascular diseases in China for 30 years.	Polysaccharides	59-73	PSS	Homo sapiens	42-45
30049713-5	2018	Targeting surface-expressed PHBs on Th17 cells with ligands such as Vi polysaccharide (Typhim vaccine) inhibited CRAF-MAPK pathway, reduced interleukin (IL)-17 expression and ameliorated disease pathology with an increase in FOXP3+-expressing Tregs in an animal model for multiple sclerosis (MS).	Polysaccharides	71-85	interleukin 17A	Homo sapiens	140-159
29969553-4	2018	In murine models of immunization, however, such conjugates traffic to lymph nodes, where they are "unmasked", releasing the small molecule TLR7/8 agonist from the carrier polysaccharide.	Polysaccharides	171-185	toll-like receptor 7	Mus musculus	139-143
30049713-5	2018	Targeting surface-expressed PHBs on Th17 cells with ligands such as Vi polysaccharide (Typhim vaccine) inhibited CRAF-MAPK pathway, reduced interleukin (IL)-17 expression and ameliorated disease pathology with an increase in FOXP3+-expressing Tregs in an animal model for multiple sclerosis (MS).	Polysaccharides	71-85	forkhead box P3	Homo sapiens	225-230
30006375-0	2018	IL-7 Enables Antibody Responses to Bacterial Polysaccharides by Promoting B Cell Receptor Diversity.	Polysaccharides	45-60	interleukin 7	Mus musculus	0-4
30210688-0	2018	Polysaccharide extracted from Portulacae Oleracea L. exerts protective effects against dextran sulfate sodium-induced colitis through inhibition of NF-kappaB.	Polysaccharides	0-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	148-157
30006375-8	2018	Transgenic expression of either IL-7 or a BCR encoded by a distal VH gene segment permitted young mice to respond efficiently to bacterial polysaccharides.	Polysaccharides	139-154	interleukin 7	Mus musculus	32-36
30042191-3	2018	In vivo, IgA alters the expression of polysaccharide utilization loci (PUL), including a functionally uncharacterized molecular family provisionally named Mucus-Associated Functional Factor (MAFF).	Polysaccharides	38-52	MAF bZIP transcription factor F	Homo sapiens	191-195
29932649-9	2018	Moreover, we showed that pLys-4RepCT silk coatings bind mucins through electrostatic interactions, while hGal3-4RepCT silk coatings bind mucins through specific glycan-protein interactions.	Polysaccharides	161-167	galanin and GMAP prepropeptide	Homo sapiens	105-109
29863884-14	2018	These studies not only identify the polysaccharide nanovesicle to be an improved way to efficiently deliver low concentrations of MLN8237 to inhibit AURKA but, in doing so, also help reveal a role for AURKA and its crosstalk with RalA in anchorage-independent growth of MCF-7 cells.	Polysaccharides	36-50	aurora kinase A	Homo sapiens	149-154
29884773-8	2018	We also show that the GroP-substituted glycoform synthesized by FKTN does not serve as an acceptor substrate for FKRP and that therefore further elongation of the outer glycan chain cannot occur with this glycoform.	Polysaccharides	169-175	fukutin	Homo sapiens	64-68
29863884-14	2018	These studies not only identify the polysaccharide nanovesicle to be an improved way to efficiently deliver low concentrations of MLN8237 to inhibit AURKA but, in doing so, also help reveal a role for AURKA and its crosstalk with RalA in anchorage-independent growth of MCF-7 cells.	Polysaccharides	36-50	aurora kinase A	Homo sapiens	201-206
29863884-14	2018	These studies not only identify the polysaccharide nanovesicle to be an improved way to efficiently deliver low concentrations of MLN8237 to inhibit AURKA but, in doing so, also help reveal a role for AURKA and its crosstalk with RalA in anchorage-independent growth of MCF-7 cells.	Polysaccharides	36-50	RAS like proto-oncogene A	Homo sapiens	230-234
29884773-10	2018	These results suggest that CDP-Gro inhibits the synthesis of the functional O-mannosyl glycan of alpha-DG by preventing further elongation of the glycan chain.	Polysaccharides	87-93	cut like homeobox 1	Homo sapiens	27-30
30072783-5	2018	The antigen target of A19 was identified as Erbb-2 and glycan analysis showed that A19 binds to a N-glycan epitope on the antigen.	Polysaccharides	55-61	immunoglobulin kappa variable 2-28	Homo sapiens	22-25
30072783-5	2018	The antigen target of A19 was identified as Erbb-2 and glycan analysis showed that A19 binds to a N-glycan epitope on the antigen.	Polysaccharides	55-61	immunoglobulin kappa variable 2-28	Homo sapiens	83-86
30073131-10	2018	The extracted polysaccharides composed of mannose, galactose, glucose, arabinose, xylose and rhamanose, with highest percentage of mannose (62.49%) and galactose (25.42%) in SPCA.	Polysaccharides	14-29	coagulation factor VII	Homo sapiens	174-178
29787815-8	2018	SiaBb1 may assist in the degradation of mucin glycan.	Polysaccharides	46-52	LOC100508689	Homo sapiens	40-45
30084394-0	2018	Spin ballet for sweet encounters: saturation-transfer difference NMR and X-ray crystallography complement each other in the elucidation of protein-glycan interactions.	Polysaccharides	147-153	spindlin 1	Homo sapiens	0-4
29806965-3	2018	In our present study, a water-soluble polysaccharide, named THP with molecular weight of 93 307 Da, was isolated from T. hemsleyanum by DEAE-52 ion-exchange and Sephadex G-100 chromatography.	Polysaccharides	38-52	uromodulin	Mus musculus	60-63
30058042-0	2018	Mental disorders and an acidic glycan-from the perspective of polysialic acid (PSA/polySia) and the synthesizing enzyme, ST8SIA2.	Polysaccharides	31-37	aminopeptidase puromycin sensitive	Homo sapiens	79-82
30058042-0	2018	Mental disorders and an acidic glycan-from the perspective of polysialic acid (PSA/polySia) and the synthesizing enzyme, ST8SIA2.	Polysaccharides	31-37	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	121-128
30058042-6	2018	One of the candidates of this important family of glycan epitopes in the brain is polysialic acid (PSA/polySia).	Polysaccharides	50-56	aminopeptidase puromycin sensitive	Homo sapiens	99-102
29763643-0	2018	Polysaccharide PRM3 from Rhynchosia minima root enhances immune function through TLR4-NF-kappaB pathway.	Polysaccharides	0-14	protamine 3	Mus musculus	15-19
29763643-13	2018	GENERAL SIGNIFICANCE: This study reported a polysaccharide PRM3 from R. minima root exhibited potent immunoenhancing activity and significantly alleviated cyclophosphamide-induced immunosuppression through TLR4-NF-kappaB pathway.	Polysaccharides	44-58	protamine 3	Mus musculus	59-63
29773398-0	2018	Sulfated polysaccharide mediated TGF-beta1 presentation in pre-formed injectable scaffolds for cartilage tissue engineering.	Polysaccharides	9-23	transforming growth factor beta 1	Homo sapiens	33-42
29757379-7	2018	Notably, QSOX1 lacking a glycan at this site arrives at the Golgi, suggesting that it passes endoplasmic reticulum quality control but is not further transported to the cell surface for secretion.	Polysaccharides	25-31	quiescin sulfhydryl oxidase 1	Homo sapiens	9-14
29796630-3	2018	The carbohydrate recognition domain in BDCA-2 binds selectively to galactose-terminated bi-antennary glycans.	Polysaccharides	101-108	C-type lectin domain family 4 member C	Homo sapiens	39-45
30071655-0	2018	Sargassum Fusiforme Polysaccharide SFP-F2 Activates the NF-kappaB Signaling Pathway via CD14/IKK and P38 Axes in RAW264.7 Cells.	Polysaccharides	20-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	56-65
29653172-9	2018	Our results suggested polysaccharides from purple sweetpotato possessed potential antioxidant activity and protective effect against CCl4-induced acute liver damage.	Polysaccharides	22-37	chemokine (C-C motif) ligand 4	Mus musculus	133-137
29655889-3	2018	Pat polysaccharides (TLP).	Polysaccharides	4-19	cysteine rich protein 3	Homo sapiens	21-24
30065415-0	2018	Effect of physical interactions on structure of lysozyme in presence of three kinds of polysaccharides.	Polysaccharides	87-102	lysozyme	Homo sapiens	48-56
29650365-1	2018	We reported previously that tobacco plants transformed with the human UDP-galactose transporter 1 gene (hUGT1) had enhanced growth, displayed characteristic traits, and had an increased proportion of galactose (hyper-galactosylation) in the cell wall matrix polysaccharides.	Polysaccharides	258-273	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	104-109
29650365-8	2018	The enhanced accumulation of cell wall materials might be related to the hyper-galactosylation of cell wall matrix polysaccharides, most notably arabinogalactan, because of the enhanced UDP-galactose transport from the cytosol to the Golgi apparatus by hUGT1, as suggested in our previous report.	Polysaccharides	115-130	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	253-258
30071655-0	2018	Sargassum Fusiforme Polysaccharide SFP-F2 Activates the NF-kappaB Signaling Pathway via CD14/IKK and P38 Axes in RAW264.7 Cells.	Polysaccharides	20-34	CD14 antigen	Mus musculus	88-92
30071655-0	2018	Sargassum Fusiforme Polysaccharide SFP-F2 Activates the NF-kappaB Signaling Pathway via CD14/IKK and P38 Axes in RAW264.7 Cells.	Polysaccharides	20-34	mitogen-activated protein kinase 14	Mus musculus	101-104
30071655-3	2018	However, the precise mechanisms by which these polysaccharides modulate the immune response through the NF-kappaB signaling pathway have not been elucidated.	Polysaccharides	47-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	104-113
30065303-4	2018	Likewise, Gal-1-KO-VSMC migration was inhibited by a redox-insensitive but activity-preserved Gal-1 (CSGal-1) in a glycan-dependent manner.	Polysaccharides	115-121	lectin, galactose binding, soluble 1	Mus musculus	10-15
29726048-0	2018	Role of glycans in cholesteryl ester transfer protein revealed by molecular dynamics simulation.	Polysaccharides	8-15	cholesteryl ester transfer protein	Homo sapiens	19-53
29726048-8	2018	Overall, these glycans affect the dynamics and structure of CETP through forming H-bonds with surrounding residues, and the sampled conformations of glycan is also affected by its surrounding residues.	Polysaccharides	15-22	cholesteryl ester transfer protein	Homo sapiens	60-64
29726048-8	2018	Overall, these glycans affect the dynamics and structure of CETP through forming H-bonds with surrounding residues, and the sampled conformations of glycan is also affected by its surrounding residues.	Polysaccharides	15-21	cholesteryl ester transfer protein	Homo sapiens	60-64
29726048-9	2018	Thus, glycans are an integral part of CETP, further studies on the CETP inhibition and treatment of CVD should fully consider the effect of glycans.	Polysaccharides	6-13	cholesteryl ester transfer protein	Homo sapiens	38-42
29417655-7	2018	Glycan density was calculated to be ~1200 molecules/mum2 in lower layers of SC compared to an important decrease, (~106 molecules/mum2 ) closer to the surface due probably to corneodesmosome degradation.	Polysaccharides	0-6	trafficking protein particle complex subunit 1	Homo sapiens	52-56
29417655-7	2018	Glycan density was calculated to be ~1200 molecules/mum2 in lower layers of SC compared to an important decrease, (~106 molecules/mum2 ) closer to the surface due probably to corneodesmosome degradation.	Polysaccharides	0-6	trafficking protein particle complex subunit 1	Homo sapiens	130-134
30065303-4	2018	Likewise, Gal-1-KO-VSMC migration was inhibited by a redox-insensitive but activity-preserved Gal-1 (CSGal-1) in a glycan-dependent manner.	Polysaccharides	115-121	lectin, galactose binding, soluble 1	Mus musculus	94-99
30065303-9	2018	Surface plasmon resonance assay demonstrated that CSGal-1 interacted with alpha5beta1integrin and fibronectin in a glycan-dependent manner.	Polysaccharides	115-121	fibronectin 1	Mus musculus	98-109
30018219-0	2018	Structural Divergence in O-GlcNAc Glycans Displayed on Epidermal Growth Factor-like Repeats of Mammalian Notch1.	Polysaccharides	34-41	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	25-33
30061484-12	2018	Conclusions: Our results show that K5 polysaccharides and glycyrrhizin are promising candidates for RAGE targeting drug development.	Polysaccharides	38-53	advanced glycosylation end-product specific receptor	Homo sapiens	100-104
30040854-10	2018	The levels of these two glycan features were correlated to C-reactive protein concentration, an inflammation marker and known prognostic indicator for bladder cancer, further strengthening the link between inflammation and abnormal plasma protein glycosylation.	Polysaccharides	24-30	C-reactive protein	Homo sapiens	59-77
30026537-4	2018	The binding of viral envelope glycans to L-selectin facilitates HIV entry and infection, and L-selectin expression on central memory CD4+ T cells supports their preferential infection by HIV.	Polysaccharides	30-37	selectin L	Homo sapiens	41-51
30116489-0	2018	Hepatoprotective Effect of Polysaccharides Isolated from Dendrobium officinale against Acetaminophen-Induced Liver Injury in Mice via Regulation of the Nrf2-Keap1 Signaling Pathway.	Polysaccharides	27-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	152-156
30116489-0	2018	Hepatoprotective Effect of Polysaccharides Isolated from Dendrobium officinale against Acetaminophen-Induced Liver Injury in Mice via Regulation of the Nrf2-Keap1 Signaling Pathway.	Polysaccharides	27-42	kelch-like ECH-associated protein 1	Mus musculus	157-162
30018219-5	2018	The analysis of Drosophila EGF20 expressed in HEK293T cells revealed that the majority of the proteins are modified with an elongated form of O-GlcNAc glycan comprising terminal galactose or sialic acid residues.	Polysaccharides	151-157	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	142-150
30018219-6	2018	In contrast, recombinant Notch1 EGF repeats isolated from HEK293T cells revealed structural divergence of O-GlcNAc glycans among the different EGF domains.	Polysaccharides	115-122	notch receptor 1	Homo sapiens	25-31
30018219-6	2018	In contrast, recombinant Notch1 EGF repeats isolated from HEK293T cells revealed structural divergence of O-GlcNAc glycans among the different EGF domains.	Polysaccharides	115-122	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	106-114
30018219-7	2018	Although the majority of Notch1 EGF2 and EGF20 domains contained the extended forms of the glycan, the O-GlcNAc in many other domains mostly existed as a monosaccharide irrespective of the exogenous EOGT expression.	Polysaccharides	91-97	notch receptor 1	Homo sapiens	25-31
30018230-4	2018	We have developed monovalent SE and STm glycoconjugate vaccines based on coupling lipopolysaccharide-derived core-O polysaccharide (COPS) to phase 1 flagellin protein (FliC) from the homologous serovar.	Polysaccharides	86-100	stumpy	Mus musculus	36-39
30018254-0	2018	Protective Effect of Sulfated Polysaccharides from Celluclast-Assisted Extract of Hizikia fusiforme Against Ultraviolet B-Induced Skin Damage by Regulating NF-kappaB, AP-1, and MAPKs Signaling Pathways In Vitro in Human Dermal Fibroblasts.	Polysaccharides	30-45	nuclear factor kappa B subunit 1	Homo sapiens	156-165
30038321-7	2018	Microbial functions prediction indicated a greater metabolic potential for degradation of aminoacids, lipids and ketone bodies in a-CD microbiome than in control and GFD microbiomes, in which polysaccharide metabolism predominated.	Polysaccharides	192-206	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	130-134
30018219-0	2018	Structural Divergence in O-GlcNAc Glycans Displayed on Epidermal Growth Factor-like Repeats of Mammalian Notch1.	Polysaccharides	34-41	notch receptor 1	Homo sapiens	105-111
30018219-4	2018	This study aimed to analyze the O-GlcNAc glycans of Drosophila EGF20 as model substrates and mouse Notch1 EGF repeats by mass-spectrometry.	Polysaccharides	41-48	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	32-40
29973708-6	2018	Consequently, polysaccharide formula treatment helped to recover the expression of immune-related genes, including CADM1, CCR2, IGLL1, LIGP1, and FCGR3, FCGR2 in B cells, as well as S100A8, S100A9, ChIL3, MMP8 and IFITM3 in T cells.	Polysaccharides	14-28	cell adhesion molecule 1	Mus musculus	115-120
29627471-6	2018	In vivo and in vitro experiments have demonstrated the ability of polysaccharide rich extracts to provide colon-protective effects by inducing the PI3K/AKT, NF-kappaB, and MAPK signaling pathways, the apoptosis of tumor cells, and the regulation of gut microflora.	Polysaccharides	66-80	AKT serine/threonine kinase 1	Homo sapiens	152-155
29627471-6	2018	In vivo and in vitro experiments have demonstrated the ability of polysaccharide rich extracts to provide colon-protective effects by inducing the PI3K/AKT, NF-kappaB, and MAPK signaling pathways, the apoptosis of tumor cells, and the regulation of gut microflora.	Polysaccharides	66-80	nuclear factor kappa B subunit 1	Homo sapiens	157-166
30018481-0	2018	Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-alpha-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-kappaB-myosin light chain kinase-myosin light chain pathway.	Polysaccharides	6-21	tumor necrosis factor	Homo sapiens	57-84
30018481-0	2018	Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-alpha-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-kappaB-myosin light chain kinase-myosin light chain pathway.	Polysaccharides	6-21	modulator of VRAC current 1	Homo sapiens	181-199
30018481-0	2018	Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-alpha-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-kappaB-myosin light chain kinase-myosin light chain pathway.	Polysaccharides	6-21	modulator of VRAC current 1	Homo sapiens	207-225
30042683-0	2018	Polysaccharides From Chrysanthemum morifolium Ramat Ameliorate Colitis Rats via Regulation of the Metabolic Profiling and NF-kappa B/TLR4 and IL-6/JAK2/STAT3 Signaling Pathways.	Polysaccharides	0-15	toll-like receptor 4	Rattus norvegicus	133-137
30042683-0	2018	Polysaccharides From Chrysanthemum morifolium Ramat Ameliorate Colitis Rats via Regulation of the Metabolic Profiling and NF-kappa B/TLR4 and IL-6/JAK2/STAT3 Signaling Pathways.	Polysaccharides	0-15	interleukin 6	Rattus norvegicus	142-146
30042683-0	2018	Polysaccharides From Chrysanthemum morifolium Ramat Ameliorate Colitis Rats via Regulation of the Metabolic Profiling and NF-kappa B/TLR4 and IL-6/JAK2/STAT3 Signaling Pathways.	Polysaccharides	0-15	Janus kinase 2	Rattus norvegicus	147-151
30042683-0	2018	Polysaccharides From Chrysanthemum morifolium Ramat Ameliorate Colitis Rats via Regulation of the Metabolic Profiling and NF-kappa B/TLR4 and IL-6/JAK2/STAT3 Signaling Pathways.	Polysaccharides	0-15	signal transducer and activator of transcription 3	Rattus norvegicus	152-157
29859376-1	2018	Glycan-binding protein (GBP) interaction experiments, such as glycan microarrays, are often used to understand glycan recognition patterns.	Polysaccharides	62-68	transmembrane protein 132A	Homo sapiens	0-22
29859376-1	2018	Glycan-binding protein (GBP) interaction experiments, such as glycan microarrays, are often used to understand glycan recognition patterns.	Polysaccharides	62-68	transmembrane protein 132A	Homo sapiens	24-27
29859376-1	2018	Glycan-binding protein (GBP) interaction experiments, such as glycan microarrays, are often used to understand glycan recognition patterns.	Polysaccharides	111-117	transmembrane protein 132A	Homo sapiens	0-22
29859376-1	2018	Glycan-binding protein (GBP) interaction experiments, such as glycan microarrays, are often used to understand glycan recognition patterns.	Polysaccharides	111-117	transmembrane protein 132A	Homo sapiens	24-27
29859376-2	2018	However, oftentimes the interpretation of glycan array experimental data makes it difficult to identify discrete GBP binding patterns due to their ambiguity.	Polysaccharides	42-48	transmembrane protein 132A	Homo sapiens	113-116
29859376-6	2018	In our previous work, as opposed to using predefined motifs, we developed the Multiple Carbohydrate Alignment with Weights (MCAW) tool to visualize the state of the glycans being recognized by the GBP under analysis.	Polysaccharides	165-172	transmembrane protein 132A	Homo sapiens	197-200
29859376-12	2018	Using MCAW-DB, the patterns of glycans found to bind to various GBP-glycan binding proteins are visualized, indicating the binding "environment" of the glycans.	Polysaccharides	31-38	transmembrane protein 132A	Homo sapiens	64-67
29859376-12	2018	Using MCAW-DB, the patterns of glycans found to bind to various GBP-glycan binding proteins are visualized, indicating the binding "environment" of the glycans.	Polysaccharides	31-37	transmembrane protein 132A	Homo sapiens	64-67
29859376-12	2018	Using MCAW-DB, the patterns of glycans found to bind to various GBP-glycan binding proteins are visualized, indicating the binding "environment" of the glycans.	Polysaccharides	152-159	transmembrane protein 132A	Homo sapiens	64-67
30116757-2	2018	Coriolus versicolor"s polysaccharide peptide (PSP) has been demonstrated to possess immunomodulatory properties with the ability to activate an innate immune response through Toll-like receptor 4 (TLR4) showing insignificant toxicity.	Polysaccharides	22-36	toll like receptor 4	Homo sapiens	175-195
30116757-2	2018	Coriolus versicolor"s polysaccharide peptide (PSP) has been demonstrated to possess immunomodulatory properties with the ability to activate an innate immune response through Toll-like receptor 4 (TLR4) showing insignificant toxicity.	Polysaccharides	22-36	toll like receptor 4	Homo sapiens	197-201
30022822-0	2018	Polysaccharide-modified nanoparticles with intelligent CD44 receptor targeting ability for gene delivery.	Polysaccharides	0-14	CD44 antigen	Mus musculus	55-59
29973708-6	2018	Consequently, polysaccharide formula treatment helped to recover the expression of immune-related genes, including CADM1, CCR2, IGLL1, LIGP1, and FCGR3, FCGR2 in B cells, as well as S100A8, S100A9, ChIL3, MMP8 and IFITM3 in T cells.	Polysaccharides	14-28	chemokine (C-C motif) receptor 2	Mus musculus	122-126
29973708-6	2018	Consequently, polysaccharide formula treatment helped to recover the expression of immune-related genes, including CADM1, CCR2, IGLL1, LIGP1, and FCGR3, FCGR2 in B cells, as well as S100A8, S100A9, ChIL3, MMP8 and IFITM3 in T cells.	Polysaccharides	14-28	immunoglobulin lambda-like polypeptide 1	Mus musculus	128-133
29973708-6	2018	Consequently, polysaccharide formula treatment helped to recover the expression of immune-related genes, including CADM1, CCR2, IGLL1, LIGP1, and FCGR3, FCGR2 in B cells, as well as S100A8, S100A9, ChIL3, MMP8 and IFITM3 in T cells.	Polysaccharides	14-28	Fc receptor, IgG, low affinity III	Mus musculus	146-151
29973708-6	2018	Consequently, polysaccharide formula treatment helped to recover the expression of immune-related genes, including CADM1, CCR2, IGLL1, LIGP1, and FCGR3, FCGR2 in B cells, as well as S100A8, S100A9, ChIL3, MMP8 and IFITM3 in T cells.	Polysaccharides	14-28	Fc receptor, IgG, low affinity IIb	Mus musculus	153-158
29973708-6	2018	Consequently, polysaccharide formula treatment helped to recover the expression of immune-related genes, including CADM1, CCR2, IGLL1, LIGP1, and FCGR3, FCGR2 in B cells, as well as S100A8, S100A9, ChIL3, MMP8 and IFITM3 in T cells.	Polysaccharides	14-28	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	182-188
29973708-6	2018	Consequently, polysaccharide formula treatment helped to recover the expression of immune-related genes, including CADM1, CCR2, IGLL1, LIGP1, and FCGR3, FCGR2 in B cells, as well as S100A8, S100A9, ChIL3, MMP8 and IFITM3 in T cells.	Polysaccharides	14-28	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	190-196
29973708-6	2018	Consequently, polysaccharide formula treatment helped to recover the expression of immune-related genes, including CADM1, CCR2, IGLL1, LIGP1, and FCGR3, FCGR2 in B cells, as well as S100A8, S100A9, ChIL3, MMP8 and IFITM3 in T cells.	Polysaccharides	14-28	chitinase-like 3	Mus musculus	198-203
29973708-6	2018	Consequently, polysaccharide formula treatment helped to recover the expression of immune-related genes, including CADM1, CCR2, IGLL1, LIGP1, and FCGR3, FCGR2 in B cells, as well as S100A8, S100A9, ChIL3, MMP8 and IFITM3 in T cells.	Polysaccharides	14-28	matrix metallopeptidase 8	Mus musculus	205-209
29973708-6	2018	Consequently, polysaccharide formula treatment helped to recover the expression of immune-related genes, including CADM1, CCR2, IGLL1, LIGP1, and FCGR3, FCGR2 in B cells, as well as S100A8, S100A9, ChIL3, MMP8 and IFITM3 in T cells.	Polysaccharides	14-28	interferon induced transmembrane protein 3	Mus musculus	214-220
29631057-1	2018	BACKGROUND: Langerin, a C-type lectin receptor (CLR) expressed in a subset of dendritic cells (DCs), binds to glycan ligands for pathogen capture and clearance.	Polysaccharides	110-116	CD207 antigen	Mus musculus	12-20
29631057-1	2018	BACKGROUND: Langerin, a C-type lectin receptor (CLR) expressed in a subset of dendritic cells (DCs), binds to glycan ligands for pathogen capture and clearance.	Polysaccharides	110-116	calcitonin receptor	Mus musculus	24-46
29631057-1	2018	BACKGROUND: Langerin, a C-type lectin receptor (CLR) expressed in a subset of dendritic cells (DCs), binds to glycan ligands for pathogen capture and clearance.	Polysaccharides	110-116	calcitonin receptor	Mus musculus	48-51
29631057-12	2018	GENERAL SIGNIFICANCE: These results suggest that oligomeric L4 derivatives will be useful for clarifying the langerin functions and for the development of new glycan-based anti-inflammatory drugs.	Polysaccharides	159-165	CD207 antigen	Mus musculus	109-117
29524488-3	2018	Our study shows the feasibility of using a photo-crosslinkable shell layer to regulate basal and bolus insulin release from glucose-responsive Con A-polysaccharides network.	Polysaccharides	149-164	insulin	Homo sapiens	103-110
29409697-6	2018	Although insects typically produce pauci-mannosidic-type glycans, the structure of N-glycans in the recombinant hGnTII was suggested to be of the complex type, and the removal of the glycans did not affect the enzymatic activity.	Polysaccharides	85-92	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	112-118
29329813-2	2018	Some physicochemical properties, including structure, monosaccharide composition, and molecular weight distribution, as well as the 4 in vitro antioxidant activities and inhibitory effects on alpha-glucosidase of above polysaccharides before and after removing metal ions were investigated.	Polysaccharides	219-234	sucrase-isomaltase	Homo sapiens	192-209
29763881-1	2018	beta-Glucan refers to a heterogeneous group of chemically defined storage polysaccharides containing beta-(1,3)-d-linked glucose polymers with branches connected by either beta-(1,4) or beta-(1,6) glycosidic linkage.	Polysaccharides	74-89	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9	Mus musculus	172-181
29763881-1	2018	beta-Glucan refers to a heterogeneous group of chemically defined storage polysaccharides containing beta-(1,3)-d-linked glucose polymers with branches connected by either beta-(1,4) or beta-(1,6) glycosidic linkage.	Polysaccharides	74-89	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9	Mus musculus	186-195
29720519-2	2018	In this study, we characterized the glycan binding specificities of human and porcine P[6]/P[19] RV VP8*s and found that the P[II] genogroup RV VP8*s could commonly interact with mucin core 2, which may play an important role in RV evolution and cross-species transmission.	Polysaccharides	36-42	LOC100508689	Homo sapiens	179-184
29663501-3	2018	Our study showed that the cell surface glycan chains of anaplastic 8305C, follicular FTC-133, and papillary K1 thyroid carcinoma cells were rich in alpha-2,6, alpha-2,3, sialic acid, and alpha-1,6 fucose residues.	Polysaccharides	39-45	adrenoceptor alpha 1D	Homo sapiens	187-194
30045788-9	2018	The levels of syndecan-1 (polysaccharide envelope marker) in plasma were determined by enzyme linked immunosorbent assay (ELISA).	Polysaccharides	26-40	syndecan-1	Oryctolagus cuniculus	14-24
29802217-8	2018	Glycosylation is a defining process for mucins that is specific with respect to additions of glycans to mucin apoprotein backbones, and glycan additions influence the physical properties of the mucins via structural modifications as well as charge interactions.	Polysaccharides	93-100	LOC100508689	Homo sapiens	40-45
29958399-7	2018	This study demonstrates that quercetin-containing foods may interfere with the immune-enhancing effects of Astragalus polysaccharide RAP to a certain extent.	Polysaccharides	118-132	regulatory associated protein of MTOR, complex 1	Mus musculus	133-136
29802217-8	2018	Glycosylation is a defining process for mucins that is specific with respect to additions of glycans to mucin apoprotein backbones, and glycan additions influence the physical properties of the mucins via structural modifications as well as charge interactions.	Polysaccharides	93-99	LOC100508689	Homo sapiens	40-45
29742893-5	2018	Further evaluation of the immune response revealed that the size of the liposomes influenced the glycan antibody responses toward either a cellular (Th1) or a humoral (Th2) immune phenotype.	Polysaccharides	97-103	negative elongation factor complex member C/D, Th1l	Mus musculus	149-152
29792670-5	2018	As such, Ac3ManNAz is converted to cell surface glycan bearing an azido group, which serves as an anchor to introduce l-rhamnose (Rha), a hapten, via a click reaction with aza-dibenzocyclooctyne (DBCO)-Rha.	Polysaccharides	48-54	adenylate cyclase 3	Homo sapiens	9-12
29742893-5	2018	Further evaluation of the immune response revealed that the size of the liposomes influenced the glycan antibody responses toward either a cellular (Th1) or a humoral (Th2) immune phenotype.	Polysaccharides	97-103	heart and neural crest derivatives expressed 2	Mus musculus	168-171
29951070-14	2018	Wild-type SP-D causes little inhibition of pandemic IAV, but mutated versions of SP-D were able to inhibit pandemic IAV through enhanced binding to the reduced number of mannosylated glycans present on the HA of these strains.	Polysaccharides	183-190	surfactant protein D	Homo sapiens	81-85
29951070-8	2018	Surfactant protein D (SP-D) and mannose-binding lectin (MBL) attach to mannosylated glycans on the HA in a calcium dependent manner.	Polysaccharides	84-91	surfactant protein D	Homo sapiens	0-20
29963041-1	2018	DC-SIGN is an antigen uptake receptor expressed on dendritic cells (DCs) with specificity for glycans present on a broad variety of pathogens and is capable of directing its cargo to MHC-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell responses, respectively.	Polysaccharides	94-101	CD209 molecule	Homo sapiens	0-7
29963041-1	2018	DC-SIGN is an antigen uptake receptor expressed on dendritic cells (DCs) with specificity for glycans present on a broad variety of pathogens and is capable of directing its cargo to MHC-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell responses, respectively.	Polysaccharides	94-101	CD8a molecule	Homo sapiens	230-233
29963041-1	2018	DC-SIGN is an antigen uptake receptor expressed on dendritic cells (DCs) with specificity for glycans present on a broad variety of pathogens and is capable of directing its cargo to MHC-I and MHC-II pathways for the induction of CD8+ and CD4+ T cell responses, respectively.	Polysaccharides	94-101	CD4 molecule	Homo sapiens	239-242
29951070-8	2018	Surfactant protein D (SP-D) and mannose-binding lectin (MBL) attach to mannosylated glycans on the HA in a calcium dependent manner.	Polysaccharides	84-91	surfactant protein D	Homo sapiens	22-26
29880804-9	2018	The M6PgP-conjugated rGAA had a 16-fold higher content of M6P glycan than rGAA, which resulted in greatly increased cellular uptake and efficient digestion of glycogen accumulated in Pompe disease patient fibroblasts.	Polysaccharides	62-68	alpha glucosidase	Rattus norvegicus	21-25
29951070-8	2018	Surfactant protein D (SP-D) and mannose-binding lectin (MBL) attach to mannosylated glycans on the HA in a calcium dependent manner.	Polysaccharides	84-91	mannose binding lectin 2	Homo sapiens	32-54
29951070-8	2018	Surfactant protein D (SP-D) and mannose-binding lectin (MBL) attach to mannosylated glycans on the HA in a calcium dependent manner.	Polysaccharides	84-91	mannose binding lectin 2	Homo sapiens	56-59
29705698-4	2018	However, the anti-inflammatory effect of these polysaccharides on inflammation processes occurring under Angiotensin II stimulation is yet unknown.	Polysaccharides	47-62	angiotensinogen	Homo sapiens	105-119
29705698-5	2018	Herein, we studied the polysaccharide"s anti-inflammatory effect by quantification of inflammatory markers in Angiotensin II- stimulated Human Coronary Artery Endothelial Cells following pre-treatment with polysaccharides.	Polysaccharides	23-37	angiotensinogen	Homo sapiens	110-124
29705698-6	2018	Inflammatory atherosclerotic pathways up-regulated by Angiotensin II, including adhesion molecule expression and nuclear factor kappa-light-chain-enhancer of activated B cells translocation, were significantly attenuated or diminished in cells pre-treated with the polysaccharides.	Polysaccharides	265-280	angiotensinogen	Homo sapiens	54-68
29580922-9	2018	Sialylated glycans of haptoglobin are a potential biomarker of several diseases, such as hepatocellular carcinoma, liver cirrhosis, and IgA-nephritis.	Polysaccharides	11-18	haptoglobin	Homo sapiens	22-33
29991969-6	2018	A correlation analysis was performed between the MGAT3 and BACH2 promoter methylation and individual IgG glycans, measured in the same individuals of the two large cohorts.	Polysaccharides	105-112	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	49-54
29991969-8	2018	The correlations between the BACH2 promoter methylation and IgG glycans were less obvious, since BACH2 is not a glycosyltransferase and therefore may affect IgG glycosylation only indirectly.	Polysaccharides	64-71	BTB domain and CNC homolog 2	Homo sapiens	29-34
29761603-0	2018	A "Sticky" Mucin-Inspired DNA-Polysaccharide Binder for Silicon and Silicon-Graphite Blended Anodes in Lithium-Ion Batteries.	Polysaccharides	30-44	LOC100508689	Homo sapiens	11-16
29516297-7	2018	Ca(II) is also sequestered by the carboxylate groups of sialic acid present on glycan chains of cbLf thus provoking the release of LPS, contributing to bactericidal activity.	Polysaccharides	79-85	carbonic anhydrase 2	Bos taurus	0-6
29408556-3	2018	Our objective was to identify cancer-related glycan epitopes on MUC1 and MUC5AC mucins in PDAC as potential biomarkers.	Polysaccharides	45-51	mucin 1, cell surface associated	Homo sapiens	64-68
29401627-2	2018	We used a combination of structural, biochemical, biophysical, and cell-based approaches to decipher the specificity of the interaction between mucin glycans and mammalian lectins expressed in the gut, including galectin (Gal)-3 and C-type lectin receptors.	Polysaccharides	150-157	LOC100508689	Homo sapiens	144-149
29401627-4	2018	Modification of mucin glycosylation, via chemical treatment leading to a loss of terminal glycans, promoted the interaction of Gal-3 to poly- N-acetyllactosamine.	Polysaccharides	90-97	LOC100508689	Homo sapiens	16-21
29401627-4	2018	Modification of mucin glycosylation, via chemical treatment leading to a loss of terminal glycans, promoted the interaction of Gal-3 to poly- N-acetyllactosamine.	Polysaccharides	90-97	galectin 3	Homo sapiens	127-132
29659839-1	2018	Siglec-F is a pro-apoptotic receptor on mouse eosinophils that recognizes 6"-sulfated sialyl Lewis X and 6"-sulfated sialyl N-acetyl-lactosamine as well as multivalent sialyl N-acetyl-lactosamine structures on glycan arrays.	Polysaccharides	210-216	sialic acid binding Ig-like lectin F	Mus musculus	0-8
29858715-0	2018	Unusual N-type glycosylation of salivary prolactin-inducible protein (PIP): multiple LewisY epitopes generate highly-fucosylated glycan structures.	Polysaccharides	129-135	prolactin induced protein	Homo sapiens	41-68
29858715-0	2018	Unusual N-type glycosylation of salivary prolactin-inducible protein (PIP): multiple LewisY epitopes generate highly-fucosylated glycan structures.	Polysaccharides	129-135	prolactin induced protein	Homo sapiens	70-73
29858715-6	2018	PIP carries unusual highly fucosylated N-linked glycans with multiple Lewisy (Ley) epitopes on bi-, tri- and tetraantennary structures resulting in up to nine fucosyl residues on a tetraantennary glycan.	Polysaccharides	48-54	prolactin induced protein	Homo sapiens	0-3
29408556-3	2018	Our objective was to identify cancer-related glycan epitopes on MUC1 and MUC5AC mucins in PDAC as potential biomarkers.	Polysaccharides	45-51	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	73-79
29233911-11	2018	The comprehensive characterization of C1-Inh glycosylation described in this study will form the basis for further functional studies on the role of these glycan modifications.	Polysaccharides	155-161	serpin family G member 1	Homo sapiens	38-44
29581231-0	2018	Intestinal mucin activates human dendritic cells and IL-8 production in a glycan-specific manner.	Polysaccharides	74-80	LOC100508689	Homo sapiens	11-16
29581231-0	2018	Intestinal mucin activates human dendritic cells and IL-8 production in a glycan-specific manner.	Polysaccharides	74-80	C-X-C motif chemokine ligand 8	Homo sapiens	53-57
29581231-8	2018	Instead, mucin glycans are important for the pro-inflammatory effects on DCs.	Polysaccharides	15-22	LOC100508689	Homo sapiens	9-14
29345352-0	2018	Achyranthes bidentata polysaccharide suppresses osteoclastogenesis and bone resorption via inhibiting RANKL signaling.	Polysaccharides	22-36	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	102-107
29762369-1	2018	OBJECTIVES: Maltase-glucoamylase and sucrase-isomaltase are enzymes in the brush-border membrane of the small intestinal lumen responsible for the breakdown of postamylase starch polysaccharides to release monomeric glucose.	Polysaccharides	179-194	sucrase-isomaltase	Homo sapiens	37-55
29945377-6	2018	In the antioxidant system, the concentration of polysaccharide was within the range of 1-7 g L-1; the antioxidant activity of HPS-MC was higher than that of HPS-R, and HPS-MC (80%) with the lowest molecular weight showed a significant dose effect relationship with the increase of the experimental concentration.	Polysaccharides	48-62	immunoglobulin kappa variable 1-16	Homo sapiens	93-96
29569779-12	2018	Biochemical and imaging data demonstrate that cinv1 cinv2 seedlings are deficient in UDP-glucose production, exhibit abnormal cellulose biosynthesis and microtubule properties, and have altered cellulose organization without substantial changes to matrix polysaccharide composition, suggesting that the CINV/UGP pathway is a key metabolic route to UDP-glucose synthesis in Arabidopsis.	Polysaccharides	255-269	cytosolic invertase 1	Arabidopsis thaliana	46-57
29687791-6	2018	We further applied this approach to study the glycosylation alterations in PKM2 knockout cells vs. parental breast cancer cells and revealed altered N-glycoprotein/N-glycopeptide patterns and very different glycosylation microheterogeneity for different types of glycans.	Polysaccharides	263-270	pyruvate kinase M1/2	Homo sapiens	75-79
29587225-2	2018	EPO glycans carry extensive sialylation and the level of the modification is known to affect receptor binding, protein stability and pharmacokinetics.	Polysaccharides	4-11	erythropoietin	Homo sapiens	0-3
29784961-0	2018	Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway.	Polysaccharides	20-35	colony stimulating factor 3 (granulocyte)	Mus musculus	115-120
29795267-10	2018	Together, biochemical and bioinformatics analyses suggest that acquisition of this system appears ancient and, because only traces of two successful transfers were detected upon inspection of PL6 and PL17 families, the pace of acquisition of marine polysaccharide degradation system is probably very slow.	Polysaccharides	249-263	transmembrane protein 115	Homo sapiens	192-195
29784961-0	2018	Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway.	Polysaccharides	20-35	Janus kinase 2	Mus musculus	130-134
29784961-0	2018	Sarcodon imbricatus polysaccharides improve mouse hematopoietic function after cyclophosphamide-induced damage via G-CSF mediated JAK2/STAT3 pathway.	Polysaccharides	20-35	signal transducer and activator of transcription 3	Mus musculus	135-140
30271580-2	2018	One approach is administration of antimicrobial proteins and peptides (APPs) such as LL-37, a membrane-active cathelicidin antimicrobial peptide, and mannose-binding lectin (MBL), a pattern-recognition protein that binds to microbial surface polysaccharides resulting in opsonization and complement activation.	Polysaccharides	242-257	mannose binding lectin 2	Homo sapiens	150-172
29977381-2	2018	The bacteria protect themselves against non-specific host defence by an external polysaccharide (PS) capsule which bears a repeating unit, alpha-D-Galp(1-&gt;3)-alpha-D-Glcp(1-&gt;3)-alpha-L-Rhap(1-&gt;3)-D-Rib (SPn 6A).	Polysaccharides	81-95	galanin like peptide	Homo sapiens	147-151
30271580-2	2018	One approach is administration of antimicrobial proteins and peptides (APPs) such as LL-37, a membrane-active cathelicidin antimicrobial peptide, and mannose-binding lectin (MBL), a pattern-recognition protein that binds to microbial surface polysaccharides resulting in opsonization and complement activation.	Polysaccharides	242-257	mannose binding lectin 2	Homo sapiens	174-177
29977381-2	2018	The bacteria protect themselves against non-specific host defence by an external polysaccharide (PS) capsule which bears a repeating unit, alpha-D-Galp(1-&gt;3)-alpha-D-Glcp(1-&gt;3)-alpha-L-Rhap(1-&gt;3)-D-Rib (SPn 6A).	Polysaccharides	97-99	galanin like peptide	Homo sapiens	147-151
29769533-4	2018	Quantitative site-specific analysis of the glycan shield reveals that native-like glycan processing is maintained despite furin-independent maturation in the secretory pathway.	Polysaccharides	43-49	furin, paired basic amino acid cleaving enzyme	Homo sapiens	122-127
29581232-6	2018	The effects of knocking down the expression of galectin 3, a carbohydrate-binding protein and an important player in galectin-glycan interactions, were also cargo-specific and stimulated CD59 uptake.	Polysaccharides	126-132	galectin 3	Homo sapiens	47-57
29892355-1	2018	The endo-beta-N-acetylglucosaminidase mutant endo-CC N180H transfers glycan from sialylglycopeptide (SGP) to various acceptors.	Polysaccharides	69-75	O-GlcNAcase	Homo sapiens	9-37
29892355-5	2018	Glycan remodelling of antibodies was explored using core-fucose-deficient anti-CCR4 antibody with SGP and endo-CC N180H.	Polysaccharides	0-6	C-C motif chemokine receptor 4	Homo sapiens	79-83
29593094-1	2018	In humans, six alpha(1,3)-fucosyltransferases (alpha(1,3)-FTs: FT3/FT4/FT5/FT6/FT7/FT9) reportedly fucosylate terminal lactosaminyl glycans yielding Lewis-X (LeX; CD15) and/or sialyl Lewis-X (sLeX; CD15s), structures that play key functions in cell migration, development, and immunity.	Polysaccharides	132-139	fucosyltransferase 4	Homo sapiens	163-167
29581232-6	2018	The effects of knocking down the expression of galectin 3, a carbohydrate-binding protein and an important player in galectin-glycan interactions, were also cargo-specific and stimulated CD59 uptake.	Polysaccharides	126-132	CD59 molecule (CD59 blood group)	Homo sapiens	187-191
29593094-1	2018	In humans, six alpha(1,3)-fucosyltransferases (alpha(1,3)-FTs: FT3/FT4/FT5/FT6/FT7/FT9) reportedly fucosylate terminal lactosaminyl glycans yielding Lewis-X (LeX; CD15) and/or sialyl Lewis-X (sLeX; CD15s), structures that play key functions in cell migration, development, and immunity.	Polysaccharides	132-139	fucosyltransferase 4	Homo sapiens	183-190
29581232-7	2018	By contrast, inhibition of all galectin-glycan interactions by lactose inhibited CIE of both MHCI and CD59.	Polysaccharides	40-46	CD59 molecule (CD59 blood group)	Homo sapiens	102-106
29593094-1	2018	In humans, six alpha(1,3)-fucosyltransferases (alpha(1,3)-FTs: FT3/FT4/FT5/FT6/FT7/FT9) reportedly fucosylate terminal lactosaminyl glycans yielding Lewis-X (LeX; CD15) and/or sialyl Lewis-X (sLeX; CD15s), structures that play key functions in cell migration, development, and immunity.	Polysaccharides	132-139	fucosyltransferase 4	Homo sapiens	149-156
29593094-1	2018	In humans, six alpha(1,3)-fucosyltransferases (alpha(1,3)-FTs: FT3/FT4/FT5/FT6/FT7/FT9) reportedly fucosylate terminal lactosaminyl glycans yielding Lewis-X (LeX; CD15) and/or sialyl Lewis-X (sLeX; CD15s), structures that play key functions in cell migration, development, and immunity.	Polysaccharides	132-139	fucosyltransferase 4	Homo sapiens	158-161
29746590-6	2018	Cross-links were also observed within gp120 at sites associated with the N241/N289 glycan hole that locally modified trimer antigenicity.	Polysaccharides	83-89	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	38-43
29861828-5	2018	The results from the cell model showed that pretreatment of HUVEC with the water or alkaline extracts of the polysaccharides from the huskless barley cultivars QHH and NLGL decreased the levels of reactive oxygen species (ROS), monocyte chemotactic protein 1 (MCP-1), and vascular cell adhesion molecule 1 (VCAM-1) but increased the level of superoxide dismutase (SOD) and maintained cell viability.	Polysaccharides	109-124	chemokine (C-C motif) ligand 2	Mus musculus	260-265
29502007-0	2018	Comprehensive glycan analysis of twelve recombinant human erythropoietin preparations from manufacturers in China and Japan.	Polysaccharides	14-20	erythropoietin	Homo sapiens	58-72
29565587-1	2018	We first observed that protein/polysaccharide interaction exhibited noninteracting behavior which makes Bowman-Birk chymotrypsin inhibitor (BBI) always free of complexation, being separated from another protein with similar isoelectric points, Kunitz trypsin inhibitor (KTI).	Polysaccharides	31-45	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	121-138
29867757-2	2018	Macroheterogeneity results in three physiologically relevant FSHbeta subunit variants, two that possess a single N-linked glycan at either one of the two betaL1 loop glycosylation sites or one with both glycans.	Polysaccharides	203-210	follicle stimulating hormone subunit beta	Homo sapiens	61-68
29638128-4	2018	Herein, we report the total synthesis of threonine bearing sialyl LewisX (sLeX) linked to a Core-1- O-hexasaccharide 1, as a key glycan of the N-terminal domain of PSGL-1.	Polysaccharides	129-135	selectin P ligand	Homo sapiens	164-170
29706535-0	2018	Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation.	Polysaccharides	62-68	endoplasmic reticulum lectin 1	Homo sapiens	36-41
29706535-0	2018	Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation.	Polysaccharides	62-68	OS9 endoplasmic reticulum lectin	Homo sapiens	46-49
29706535-0	2018	Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation.	Polysaccharides	77-83	endoplasmic reticulum lectin 1	Homo sapiens	36-41
29706535-0	2018	Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation.	Polysaccharides	77-83	OS9 endoplasmic reticulum lectin	Homo sapiens	46-49
29861828-5	2018	The results from the cell model showed that pretreatment of HUVEC with the water or alkaline extracts of the polysaccharides from the huskless barley cultivars QHH and NLGL decreased the levels of reactive oxygen species (ROS), monocyte chemotactic protein 1 (MCP-1), and vascular cell adhesion molecule 1 (VCAM-1) but increased the level of superoxide dismutase (SOD) and maintained cell viability.	Polysaccharides	109-124	vascular cell adhesion molecule 1	Mus musculus	272-305
29861828-5	2018	The results from the cell model showed that pretreatment of HUVEC with the water or alkaline extracts of the polysaccharides from the huskless barley cultivars QHH and NLGL decreased the levels of reactive oxygen species (ROS), monocyte chemotactic protein 1 (MCP-1), and vascular cell adhesion molecule 1 (VCAM-1) but increased the level of superoxide dismutase (SOD) and maintained cell viability.	Polysaccharides	109-124	vascular cell adhesion molecule 1	Mus musculus	307-313
29619832-0	2018	Recombinant Human Lysyl Oxidase-like 2 Secreted from Human Embryonic Kidney Cells Displays Complex and Acidic Glycans at All Three N-Linked Glycosylation Sites.	Polysaccharides	110-117	lysyl oxidase like 2	Homo sapiens	18-38
29265394-5	2018	A1958 (C4BP peptide with two fully sialylated biantennary glycans) was selected as a marker of FS-C4BP because its level in serum was highest among FS-C4BP family members.	Polysaccharides	58-65	complement component 4 binding protein alpha	Homo sapiens	7-11
29631050-13	2018	Three major xenoantigens present on commercial BHVs, Galactosea alpha1,3 galactose (alphaGal), N-glycolylneuraminic acid (Neu5Gc) and glycan products of beta-1,4-N-acetyl-galactosaminyl transferase 2 (beta4GalNT2) are eliminated through CRISPR/Cas9 mediated gene targeting in the present study.	Polysaccharides	134-140	beta-1,4 N-acetylgalactosaminyltransferase 2	Sus scrofa	153-199
29718999-0	2018	Glycoengineering HIV-1 Env creates "supercharged" and "hybrid" glycans to increase neutralizing antibody potency, breadth and saturation.	Polysaccharides	63-70	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	23-26
29718999-3	2018	To investigate how Env glycan maturation regulates HIV sensitivity to bnAbs, we modified HIV-1 pseudovirus (PV) using various glycoengineering (GE) tools.	Polysaccharides	23-29	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	19-22
29733234-8	2018	CE-LIF analysis revealed statistically significant increases in bisecting glycans FA2BG2 (p = .006) and FABG2S1 (p = .005) seropositive RA, accompanied by decrease of bisecting monogalactosylated glycan FA2(6)G1 (p = .074) and non-bisecting monosialylated glycan FA2(3)G1S1 (p = .055).	Polysaccharides	74-81	LIF interleukin 6 family cytokine	Homo sapiens	3-6
29733234-8	2018	CE-LIF analysis revealed statistically significant increases in bisecting glycans FA2BG2 (p = .006) and FABG2S1 (p = .005) seropositive RA, accompanied by decrease of bisecting monogalactosylated glycan FA2(6)G1 (p = .074) and non-bisecting monosialylated glycan FA2(3)G1S1 (p = .055).	Polysaccharides	74-80	LIF interleukin 6 family cytokine	Homo sapiens	3-6
29265394-7	2018	An area under the curve analysis of the FS-C4BP index receiver operating characteristic curve revealed that the ratio between A1958 and A1813 (C4BP peptide with two partially sialylated biantennary glycans) reached 85%.	Polysaccharides	198-205	complement component 4 binding protein alpha	Homo sapiens	43-47
29265394-7	2018	An area under the curve analysis of the FS-C4BP index receiver operating characteristic curve revealed that the ratio between A1958 and A1813 (C4BP peptide with two partially sialylated biantennary glycans) reached 85%.	Polysaccharides	198-205	complement component 4 binding protein alpha	Homo sapiens	143-147
29465753-0	2018	Size and molecular weight determination of polysaccharides by means of nano electrospray gas-phase electrophoretic mobility molecular analysis (nES GEMMA).	Polysaccharides	43-58	nestin	Homo sapiens	144-147
29494957-0	2018	Polysaccharide isolated from Aloe vera gel suppresses ovalbumin-induced food allergy through inhibition of Th2 immunity in mice.	Polysaccharides	0-14	heart and neural crest derivatives expressed 2	Mus musculus	107-110
29465753-7	2018	In the present study, we focused on nES GEMMA of linear and branched, water-soluble polysaccharides forming nanoparticles and were able to obtain spectra for both analyte classes regarding single-charged species.	Polysaccharides	84-99	nestin	Homo sapiens	36-39
29390163-3	2018	Internally sialylated glycans were enriched by digestion of pyridylaminated glycans prepared from sera with alpha-neuraminidase from Salmonella typhimurium, which did not cleave sialic acids linked to internal residues, followed by anion-exchange chromatography.	Polysaccharides	22-29	neuraminidase 1	Homo sapiens	114-127
29390163-3	2018	Internally sialylated glycans were enriched by digestion of pyridylaminated glycans prepared from sera with alpha-neuraminidase from Salmonella typhimurium, which did not cleave sialic acids linked to internal residues, followed by anion-exchange chromatography.	Polysaccharides	76-83	neuraminidase 1	Homo sapiens	114-127
29317237-0	2018	Antitumor immunostimulatory activity of polysaccharides from Panax japonicus C. A. Mey: Roles of their effects on CD4+ T cells and tumor associated macrophages.	Polysaccharides	40-55	CD4 antigen	Mus musculus	114-117
29512724-0	2018	A novel polysaccharide derived from algae extract inhibits cancer progression via JNK, not via the p38 MAPK signaling pathway.	Polysaccharides	8-22	mitogen-activated protein kinase 8	Homo sapiens	82-85
29512724-9	2018	Results of western blot analysis demonstrated that phosphorylation of JNK and expression of p53, caspase-9 and caspase-3 were upregulated in the polysaccharide-treated MCF-7 cells.	Polysaccharides	145-159	caspase 3	Homo sapiens	111-120
29512724-9	2018	Results of western blot analysis demonstrated that phosphorylation of JNK and expression of p53, caspase-9 and caspase-3 were upregulated in the polysaccharide-treated MCF-7 cells.	Polysaccharides	145-159	mitogen-activated protein kinase 8	Homo sapiens	70-73
29512724-10	2018	SP600125, an inhibitor of JNK, maintained MCF-7 cell viability, prevented cell apoptosis and cycle arrest, and downregulated the polysaccharide-induced protein phosphorylation/expression.	Polysaccharides	129-143	mitogen-activated protein kinase 8	Homo sapiens	26-29
29512724-12	2018	Taken together, the current study demonstrated that the novel polysaccharide suppressed cancer cell growth, induced cancer cell apoptosis and cell cycle arrest via JNK signaling, but had no effect on cancer cell migration and p38 MAPK signaling.	Polysaccharides	62-76	mitogen-activated protein kinase 8	Homo sapiens	164-167
29512724-9	2018	Results of western blot analysis demonstrated that phosphorylation of JNK and expression of p53, caspase-9 and caspase-3 were upregulated in the polysaccharide-treated MCF-7 cells.	Polysaccharides	145-159	tumor protein p53	Homo sapiens	92-95
29512724-9	2018	Results of western blot analysis demonstrated that phosphorylation of JNK and expression of p53, caspase-9 and caspase-3 were upregulated in the polysaccharide-treated MCF-7 cells.	Polysaccharides	145-159	caspase 9	Homo sapiens	97-106
29567576-0	2018	The human natural killer-1 (HNK-1) glycan mimetic ursolic acid promotes functional recovery after spinal cord injury in mouse.	Polysaccharides	35-41	beta-1,3-glucuronyltransferase 1	Homo sapiens	28-33
29205553-8	2018	Based on a panel of 40 lectins, the lectin array revealed discriminant patterns of lectin binding to Vn glycans.	Polysaccharides	104-111	vitronectin	Homo sapiens	101-103
29205553-11	2018	The model of ConA binding during thermal unfolding of Vn confirmed the higher accessibility of mannosylated glycans in Vn from ascites as monitored by turbidimetry.	Polysaccharides	108-115	vitronectin	Homo sapiens	54-56
29205553-11	2018	The model of ConA binding during thermal unfolding of Vn confirmed the higher accessibility of mannosylated glycans in Vn from ascites as monitored by turbidimetry.	Polysaccharides	108-115	vitronectin	Homo sapiens	119-121
29517941-0	2018	Polysaccharide from Angelica sinensis protects H9c2 cells against oxidative injury and endoplasmic reticulum stress by activating the ATF6 pathway.	Polysaccharides	0-14	activating transcription factor 6	Rattus norvegicus	134-138
29567576-1	2018	Human natural killer-1 (HNK-1) cell antigen is a glycan epitope involved in several neural events, such as neuritogenesis, myelination, synaptic plasticity and regeneration of the nervous system after injury.	Polysaccharides	49-55	beta-1,3-glucuronyltransferase 1	Homo sapiens	24-29
29215790-2	2018	These glycans in tumor circulating cells mediate binding to vascular E-selectin, initiating tumor extravasation.	Polysaccharides	6-13	selectin E	Homo sapiens	69-79
29431199-3	2018	Interruption of beta1,6-GlcNAc glycan modification of CD147/basigin decreased matrix metalloproteinase (MMP) expression in HCC cell lines and affected the interaction of CD147/basigin with integrin beta1.	Polysaccharides	31-37	basigin (Ok blood group)	Homo sapiens	176-183
29431199-3	2018	Interruption of beta1,6-GlcNAc glycan modification of CD147/basigin decreased matrix metalloproteinase (MMP) expression in HCC cell lines and affected the interaction of CD147/basigin with integrin beta1.	Polysaccharides	31-37	integrin subunit beta 1	Homo sapiens	189-203
29431199-2	2018	In the current study, we report that GnT-V-mediated N-glycosylation of CD147/basigin, a tumor-associated glycoprotein that carries beta1,6-N-acetylglucosamine (beta1,6-GlcNAc) glycans, is upregulated during TGF-beta1-induced epithelial-to-mesenchymal transition (EMT), which correlates with tumor metastasis in patients with hepatocellular carcinoma (HCC).	Polysaccharides	176-183	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	37-42
29431199-2	2018	In the current study, we report that GnT-V-mediated N-glycosylation of CD147/basigin, a tumor-associated glycoprotein that carries beta1,6-N-acetylglucosamine (beta1,6-GlcNAc) glycans, is upregulated during TGF-beta1-induced epithelial-to-mesenchymal transition (EMT), which correlates with tumor metastasis in patients with hepatocellular carcinoma (HCC).	Polysaccharides	176-183	basigin (Ok blood group)	Homo sapiens	71-76
29431199-2	2018	In the current study, we report that GnT-V-mediated N-glycosylation of CD147/basigin, a tumor-associated glycoprotein that carries beta1,6-N-acetylglucosamine (beta1,6-GlcNAc) glycans, is upregulated during TGF-beta1-induced epithelial-to-mesenchymal transition (EMT), which correlates with tumor metastasis in patients with hepatocellular carcinoma (HCC).	Polysaccharides	176-183	basigin (Ok blood group)	Homo sapiens	77-84
29431199-3	2018	Interruption of beta1,6-GlcNAc glycan modification of CD147/basigin decreased matrix metalloproteinase (MMP) expression in HCC cell lines and affected the interaction of CD147/basigin with integrin beta1.	Polysaccharides	31-37	basigin (Ok blood group)	Homo sapiens	54-59
29431199-3	2018	Interruption of beta1,6-GlcNAc glycan modification of CD147/basigin decreased matrix metalloproteinase (MMP) expression in HCC cell lines and affected the interaction of CD147/basigin with integrin beta1.	Polysaccharides	31-37	basigin (Ok blood group)	Homo sapiens	60-67
29431199-3	2018	Interruption of beta1,6-GlcNAc glycan modification of CD147/basigin decreased matrix metalloproteinase (MMP) expression in HCC cell lines and affected the interaction of CD147/basigin with integrin beta1.	Polysaccharides	31-37	basigin (Ok blood group)	Homo sapiens	170-175
29446495-0	2018	The role of COBRA-LIKE 2 function, as part of the complex network of interacting pathways regulating Arabidopsis seed mucilage polysaccharide matrix organization.	Polysaccharides	127-141	COBRA-like protein 2 precursor	Arabidopsis thaliana	12-24
29568947-1	2018	Low molecular weight fucoidan (LMWF) is a sulfated polysaccharide extracted from Saccharina Japonica that presents high affinity for P-selectin and abolish selectin-dependent recruitment of leukocytes.	Polysaccharides	51-65	selectin, platelet	Mus musculus	133-143
29568914-0	2018	Tumor necrosis factor-alpha-induced protein 8-like-2 is involved in the activation of macrophages by Astragalus polysaccharides in vitro.	Polysaccharides	112-127	tumor necrosis factor, alpha-induced protein 8-like 2	Mus musculus	0-52
29624058-4	2018	As the ratio of zein to pectin in the particles was 1:1, their wetting properties in the two polysaccharides were similar, which made them accumulate at the interface and cover the WCS-rich droplets.	Polysaccharides	93-108	zein	Zea mays	16-20
29666272-3	2018	A key committed step in the synthesis of complex-type glycans is catalyzed by N-acetylglucosaminyltransferase II (MGAT2), an enzyme that generates the second GlcNAcbeta1,2- branch from the trimannosyl glycan core using UDP-GlcNAc as the sugar donor.	Polysaccharides	54-61	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	114-119
29666272-3	2018	A key committed step in the synthesis of complex-type glycans is catalyzed by N-acetylglucosaminyltransferase II (MGAT2), an enzyme that generates the second GlcNAcbeta1,2- branch from the trimannosyl glycan core using UDP-GlcNAc as the sugar donor.	Polysaccharides	54-60	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	114-119
29666272-6	2018	MGAT2 interactions with the extended glycan acceptor are distinct from other related glycosyltransferases.	Polysaccharides	37-43	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	0-5
29666272-10	2018	More broadly, the MGAT2 active-site architecture demonstrates how glycosyltransferases create complementary modular templates for regiospecific extension of glycan structures in mammalian cells.	Polysaccharides	157-163	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	18-23
29505161-8	2018	Instead, blocking flavonol synthesis or rhamnosylation can suppress rhm1 defects by diverting UDP-l-rhamnose to the synthesis of cell wall polysaccharides.	Polysaccharides	139-154	rhamnose biosynthesis 1	Arabidopsis thaliana	68-72
29499182-1	2018	T antigen (Galbeta1-3GalNAcalpha1-Ser/Thr) is an evolutionary-conserved mucin-type core 1 glycan structure in animals synthesized by core 1 beta1,3-galactosyltransferase 1 (C1GalT1).	Polysaccharides	90-96	Core 1 Galactosyltransferase A	Drosophila melanogaster	133-171
29689099-0	2018	Glycan modifications to the gp120 immunogens used in the RV144 vaccine trial improve binding to broadly neutralizing antibodies.	Polysaccharides	0-6	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	28-33
29689099-5	2018	Both of the monomeric gp120 immunogens (MN- and A244-rgp120) in the AIDSVAX B/E vaccine used in the RV144 trial were enriched for glycans containing high levels of sialic acid, and lacked critical N-linked glycosylation sites required for binding by several families of bN-mAbs.	Polysaccharides	130-137	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	22-27
29677181-0	2018	Exploiting glycan topography for computational design of Env glycoprotein antigenicity.	Polysaccharides	11-17	endogenous retrovirus group K member 20	Homo sapiens	57-60
29677181-1	2018	Mounting evidence suggests that glycans, rather than merely serving as a "shield", contribute critically to antigenicity of the HIV envelope (Env) glycoprotein, representing critical antigenic determinants for many broadly neutralizing antibodies (bNAbs).	Polysaccharides	32-39	endogenous retrovirus group K member 20	Homo sapiens	142-145
29569918-2	2018	Here, we report on the development of chemoenzymatic histology of membrane polysaccharide (CHoMP)-based methods for the detection of O- and N-linked glycans on tissue sections via the use of sialyltransferases ST3Gal1 and ST6Gal1, respectively.	Polysaccharides	75-89	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Homo sapiens	210-217
29569918-2	2018	Here, we report on the development of chemoenzymatic histology of membrane polysaccharide (CHoMP)-based methods for the detection of O- and N-linked glycans on tissue sections via the use of sialyltransferases ST3Gal1 and ST6Gal1, respectively.	Polysaccharides	75-89	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	222-229
29455993-0	2018	Polysaccharide from Ostrea rivularis attenuates reproductive oxidative stress damage via activating Keap1-Nrf2/ARE pathway.	Polysaccharides	0-14	kelch-like ECH-associated protein 1	Mus musculus	100-105
29455993-0	2018	Polysaccharide from Ostrea rivularis attenuates reproductive oxidative stress damage via activating Keap1-Nrf2/ARE pathway.	Polysaccharides	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	106-110
29500265-10	2018	Finally, this work shows the importance of taking microbial strain-level differences into account in gut microbiota research.IMPORTANCE It is well known that bifidobacteria degrade undigestible complex polysaccharides, such as ITF and AXOS, in the human colon.	Polysaccharides	202-217	trefoil factor 3	Homo sapiens	227-230
29455993-1	2018	The purpose of this study was to investigate the effects of Ostrea rivularis polysaccharide (ORP) against testicular oxidative stress injury via kelch-like ECH-associated protein 1-nuclear erythroid 2-related factor 2/antioxidant response element (Keap1-Nrf2/ARE) pathway.	Polysaccharides	77-91	nuclear factor, erythroid derived 2, like 2	Mus musculus	254-258
29456014-4	2018	The polysaccharide mixture and isolated fractions inhibited the production of inflammatory cytokines (TNF-alpha and IL-1beta) and mediator (NO) in RAW 264.7 cells stimulated with LPS.	Polysaccharides	4-18	tumor necrosis factor	Mus musculus	102-111
29456014-4	2018	The polysaccharide mixture and isolated fractions inhibited the production of inflammatory cytokines (TNF-alpha and IL-1beta) and mediator (NO) in RAW 264.7 cells stimulated with LPS.	Polysaccharides	4-18	interleukin 1 beta	Mus musculus	116-124
29455993-1	2018	The purpose of this study was to investigate the effects of Ostrea rivularis polysaccharide (ORP) against testicular oxidative stress injury via kelch-like ECH-associated protein 1-nuclear erythroid 2-related factor 2/antioxidant response element (Keap1-Nrf2/ARE) pathway.	Polysaccharides	77-91	kelch-like ECH-associated protein 1	Mus musculus	248-253
29499182-13	2018	Therefore, these results demonstrate that glucuronylated core 1 glycans synthesized by dGlcAT-P are key modulators of NMJ bouton localization, basement membrane formation, and NMJ arborization on larval muscles.	Polysaccharides	64-71	Glucuronyltransferase P	Drosophila melanogaster	87-95
29652849-1	2018	After generating much interest in the past as an aid in solving structural problems for complex molecules such as polysaccharides, carbohydrate-hydrolyzing enzymes of marine origin still appear as interesting biocatalysts for a range of useful applications in strong interdisciplinary fields such as green chemistry and similar domains.	Polysaccharides	114-129	activation induced cytidine deaminase	Homo sapiens	49-52
29475941-7	2018	In our effort to eliminate the remaining complex-type glycans, we found that knocking out a gene encoding the endoplasmic reticulum mannosidase I (MAN1B1) in the double KO cells reduced most of the complex-type glycans.	Polysaccharides	54-61	mannosidase alpha class 1B member 1	Homo sapiens	147-153
29518324-8	2018	Moreover, when grown under Mg2+ limitation, both the wild type and the arnB mutant exhibited a reduction in the level of membrane-bound polysaccharides.	Polysaccharides	136-151	UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase	Pseudomonas aeruginosa PAO1	71-75
29475941-7	2018	In our effort to eliminate the remaining complex-type glycans, we found that knocking out a gene encoding the endoplasmic reticulum mannosidase I (MAN1B1) in the double KO cells reduced most of the complex-type glycans.	Polysaccharides	211-218	mannosidase alpha class 1B member 1	Homo sapiens	147-153
29475941-9	2018	Therefore, we expressed two lysosomal enzymes, alpha-galactosidase-A and lysosomal acid lipase, in the triple KO cells and found that the glycans on these enzymes were sensitive to endoglycosidase H treatment.	Polysaccharides	138-145	galactosidase alpha	Homo sapiens	47-68
29706962-1	2018	Immunoglobulin G (IgG) can contain N-linked glycans in the variable domains, the so-called Fab glycans, in addition to the Fc glycans in the CH2 domains.	Polysaccharides	44-51	FA complementation group B	Homo sapiens	91-94
29706962-3	2018	We investigated whether Fab glycans may-in addition to affecting antigen binding-contribute to antibody stability.	Polysaccharides	28-35	FA complementation group B	Homo sapiens	24-27
29706962-4	2018	By analyzing thermal unfolding profiles of antibodies with or without Fab glycans, we demonstrate that introduction of Fab glycans can improve antibody stability.	Polysaccharides	74-81	FA complementation group B	Homo sapiens	119-122
29706962-4	2018	By analyzing thermal unfolding profiles of antibodies with or without Fab glycans, we demonstrate that introduction of Fab glycans can improve antibody stability.	Polysaccharides	123-130	FA complementation group B	Homo sapiens	70-73
29706962-4	2018	By analyzing thermal unfolding profiles of antibodies with or without Fab glycans, we demonstrate that introduction of Fab glycans can improve antibody stability.	Polysaccharides	123-130	FA complementation group B	Homo sapiens	119-122
29706962-7	2018	These findings indicate that introducing Fab glycans may represent a mechanism to improve therapeutic/diagnostic antibody stability.	Polysaccharides	45-52	FA complementation group B	Homo sapiens	41-44
29630683-5	2018	These HA1 mutations also increased binding affinity for 3"SLN glycan compared to the wild-type virus as measured by Biacore surface plasmon resonance method.	Polysaccharides	62-68	Rho GTPase activating protein 45	Homo sapiens	6-9
29630683-5	2018	These HA1 mutations also increased binding affinity for 3"SLN glycan compared to the wild-type virus as measured by Biacore surface plasmon resonance method.	Polysaccharides	62-68	sarcolipin	Homo sapiens	58-61
29528123-5	2018	This zwitterionic polysaccharide has a critical impact on the development of the mammalian immune system and also on the stimulation of interleukin 10-producing CD4+ T cells; consequently, PSA confers benefits to the host with regard to experimental autoimmune, inflammatory, and infectious diseases.	Polysaccharides	18-32	interleukin 10	Homo sapiens	136-150
29428665-0	2018	Astragalus polysaccharide enhanced antitumor effects of Apatinib in gastric cancer AGS cells by inhibiting AKT signalling pathway.	Polysaccharides	11-25	AKT serine/threonine kinase 1	Homo sapiens	107-110
29133093-5	2018	Polysaccharides induced RAW264.7 macrophage cells to release noticeable amounts of nitric oxide and cytokines including IL-1beta, TNF-alpha, IL-6, IL-10 and IL-12 through NF-kappaB and MAPKs signaling pathways.	Polysaccharides	0-15	tumor necrosis factor	Mus musculus	130-139
29502191-9	2018	The presence of these unusual complex N-glycans resulted in stronger interactions of cellular glycoproteins with the PHA-L. Based on the data presented here we conclude that elevated activity of GnT-III in cancer cells does not necessarily lead to a total abrogation of the formation of highly branched glycans.	Polysaccharides	40-47	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	195-202
29133093-5	2018	Polysaccharides induced RAW264.7 macrophage cells to release noticeable amounts of nitric oxide and cytokines including IL-1beta, TNF-alpha, IL-6, IL-10 and IL-12 through NF-kappaB and MAPKs signaling pathways.	Polysaccharides	0-15	interleukin 1 beta	Mus musculus	120-128
29388006-3	2018	For selection of the glycan "vector", a library of 229 fluorescent glycoprobes was employed to assess interaction with the CD14low/-CD16+CD83+ blood mononuclear cell population containing the DCs known for their importance in antigen presentation to T-lymphocytes.	Polysaccharides	21-27	CD14 molecule	Homo sapiens	123-127
29388006-3	2018	For selection of the glycan "vector", a library of 229 fluorescent glycoprobes was employed to assess interaction with the CD14low/-CD16+CD83+ blood mononuclear cell population containing the DCs known for their importance in antigen presentation to T-lymphocytes.	Polysaccharides	21-27	Fc gamma receptor IIIa	Homo sapiens	132-136
29388006-3	2018	For selection of the glycan "vector", a library of 229 fluorescent glycoprobes was employed to assess interaction with the CD14low/-CD16+CD83+ blood mononuclear cell population containing the DCs known for their importance in antigen presentation to T-lymphocytes.	Polysaccharides	21-27	CD83 molecule	Homo sapiens	137-141
29388006-5	2018	Considering the published data on specificity of DCs binding, the glycans showing particular selectivity for the CD14 low/-CD16+CD83+ cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2.	Polysaccharides	66-73	CD14 molecule	Homo sapiens	113-117
29388006-5	2018	Considering the published data on specificity of DCs binding, the glycans showing particular selectivity for the CD14 low/-CD16+CD83+ cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2.	Polysaccharides	66-73	Fc gamma receptor IIIa	Homo sapiens	123-127
29388006-5	2018	Considering the published data on specificity of DCs binding, the glycans showing particular selectivity for the CD14 low/-CD16+CD83+ cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2.	Polysaccharides	66-73	CD83 molecule	Homo sapiens	128-132
29388006-5	2018	Considering the published data on specificity of DCs binding, the glycans showing particular selectivity for the CD14 low/-CD16+CD83+ cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2.	Polysaccharides	66-73	C-type lectin domain containing 10A	Homo sapiens	168-203
29388006-5	2018	Considering the published data on specificity of DCs binding, the glycans showing particular selectivity for the CD14 low/-CD16+CD83+ cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2.	Polysaccharides	66-73	C-type lectin domain containing 10A	Homo sapiens	205-208
29388006-5	2018	Considering the published data on specificity of DCs binding, the glycans showing particular selectivity for the CD14 low/-CD16+CD83+ cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2.	Polysaccharides	66-73	sialic acid binding Ig like lectin 7	Homo sapiens	211-219
29388006-5	2018	Considering the published data on specificity of DCs binding, the glycans showing particular selectivity for the CD14 low/-CD16+CD83+ cells are likely interacting with macrophage galactose binding lectin (MGL), siglec-7 and dectin-2.	Polysaccharides	66-73	C-type lectin domain containing 6A	Homo sapiens	224-232
29567238-7	2018	Regarding bioactivity, removal of the terminal l-fucosyl residues reduced the TNF-alpha cytokine stimulating activity of the polysaccharides in a RAW 264.7 macrophage cell-line test, whereas NF-kappaB and TLR4 affected the polysaccharide-induced TNF-alpha production.	Polysaccharides	125-140	tumor necrosis factor	Mus musculus	78-87
29567238-7	2018	Regarding bioactivity, removal of the terminal l-fucosyl residues reduced the TNF-alpha cytokine stimulating activity of the polysaccharides in a RAW 264.7 macrophage cell-line test, whereas NF-kappaB and TLR4 affected the polysaccharide-induced TNF-alpha production.	Polysaccharides	125-140	toll-like receptor 4	Mus musculus	205-209
29567238-7	2018	Regarding bioactivity, removal of the terminal l-fucosyl residues reduced the TNF-alpha cytokine stimulating activity of the polysaccharides in a RAW 264.7 macrophage cell-line test, whereas NF-kappaB and TLR4 affected the polysaccharide-induced TNF-alpha production.	Polysaccharides	125-140	tumor necrosis factor	Mus musculus	246-255
29567238-7	2018	Regarding bioactivity, removal of the terminal l-fucosyl residues reduced the TNF-alpha cytokine stimulating activity of the polysaccharides in a RAW 264.7 macrophage cell-line test, whereas NF-kappaB and TLR4 affected the polysaccharide-induced TNF-alpha production.	Polysaccharides	125-139	tumor necrosis factor	Mus musculus	78-87
29567238-7	2018	Regarding bioactivity, removal of the terminal l-fucosyl residues reduced the TNF-alpha cytokine stimulating activity of the polysaccharides in a RAW 264.7 macrophage cell-line test, whereas NF-kappaB and TLR4 affected the polysaccharide-induced TNF-alpha production.	Polysaccharides	125-139	toll-like receptor 4	Mus musculus	205-209
29567238-7	2018	Regarding bioactivity, removal of the terminal l-fucosyl residues reduced the TNF-alpha cytokine stimulating activity of the polysaccharides in a RAW 264.7 macrophage cell-line test, whereas NF-kappaB and TLR4 affected the polysaccharide-induced TNF-alpha production.	Polysaccharides	125-139	tumor necrosis factor	Mus musculus	246-255
29133093-5	2018	Polysaccharides induced RAW264.7 macrophage cells to release noticeable amounts of nitric oxide and cytokines including IL-1beta, TNF-alpha, IL-6, IL-10 and IL-12 through NF-kappaB and MAPKs signaling pathways.	Polysaccharides	0-15	interleukin 6	Mus musculus	141-145
29133093-5	2018	Polysaccharides induced RAW264.7 macrophage cells to release noticeable amounts of nitric oxide and cytokines including IL-1beta, TNF-alpha, IL-6, IL-10 and IL-12 through NF-kappaB and MAPKs signaling pathways.	Polysaccharides	0-15	interleukin 10	Mus musculus	147-152
29155159-1	2018	The anti-tumor activity of a novel polysaccharide, PRG1-1, obtained from Russula griseocarnosa sporocarp was investigated in this paper.	Polysaccharides	35-49	PRG1	Homo sapiens	51-55
29155159-2	2018	PRG1-1 has a molecular weight of 630kDa and was extracted and purified using DEAE-cellulose and gel filtration chromatography from crude polysaccharide extract of R. griseocarnosa sporocarp.	Polysaccharides	137-151	PRG1	Homo sapiens	0-4
29222846-0	2018	Influence of the three-dimensional culture of human bone marrow mesenchymal stromal cells within a macroporous polysaccharides scaffold on Pannexin 1 and Pannexin 3.	Polysaccharides	111-126	pannexin 1	Homo sapiens	139-149
29351928-2	2018	Mounting evidence indicates that the modification of proteins by O-linked N-acetylglucosamine (O-GlcNAc), the only mammalian glycan found on nuclear and cytoplasmic proteins, helps regulate T cell activation.	Polysaccharides	125-131	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	95-103
29418030-10	2018	The herein described bifunctionality of AtGALS1 may suggest that plants can produce the incredible structural diversity of polysaccharides without a dedicated glycosyltransferase for each glycosidic linkage.	Polysaccharides	123-138	glycosyltransferase family protein (DUF23)	Arabidopsis thaliana	40-47
29579062-2	2018	Although progress has been made in deciphering the molecular details of lectin and Env glycan interaction, further studies are needed to better understand Env glycan heterogeneity among HIV-1 isolates and its influence on virus-neutralization sensitivity to lectins.	Polysaccharides	87-93	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	83-86
29414772-4	2018	SP-D also exhibited an affinity to two cell-wall polysaccharides of A. fumigatus, galactomannan (GM) and galactosaminogalactan (GAG).	Polysaccharides	49-64	surfactant associated protein D	Mus musculus	0-4
29593217-6	2018	The BG18-natively-glycosylated Env structures facilitate understanding of bNAb-glycan interactions critical for using V3/N332gp120 bNAbs therapeutically and targeting their epitope for immunogen design.	Polysaccharides	79-85	endogenous retrovirus group W member 1, envelope	Homo sapiens	31-34
29593217-3	2018	Here we present crystal structures, including a 3.8-A X-ray free electron laser dataset, of natively glycosylated Env trimers complexed with BG18, the most potent V3/N332gp120 glycan-targeting bNAb reported to date.	Polysaccharides	176-182	endogenous retrovirus group W member 1, envelope	Homo sapiens	114-117
29593217-4	2018	Our structures show conserved contacts mediated by common D gene-encoded residues with the N332gp120 glycan and the gp120 GDIR peptide motif, but a distinct Env-binding orientation relative to PGT121/10-1074 bNAbs.	Polysaccharides	101-107	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	95-100
29579062-10	2018	In addition, while Env of viruses enriched with mannose-type glycans were sensitive to Endo-H deglycosylation, Env of untreated viruses were partially resistant, indicating that HIV-1 Env glycans are heterogeneously comprised of complex, hybrid, and mannose types.	Polysaccharides	188-195	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	19-22
29579062-2	2018	Although progress has been made in deciphering the molecular details of lectin and Env glycan interaction, further studies are needed to better understand Env glycan heterogeneity among HIV-1 isolates and its influence on virus-neutralization sensitivity to lectins.	Polysaccharides	159-165	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	155-158
29579062-10	2018	In addition, while Env of viruses enriched with mannose-type glycans were sensitive to Endo-H deglycosylation, Env of untreated viruses were partially resistant, indicating that HIV-1 Env glycans are heterogeneously comprised of complex, hybrid, and mannose types.	Polysaccharides	188-195	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	111-114
29579062-10	2018	In addition, while Env of viruses enriched with mannose-type glycans were sensitive to Endo-H deglycosylation, Env of untreated viruses were partially resistant, indicating that HIV-1 Env glycans are heterogeneously comprised of complex, hybrid, and mannose types.	Polysaccharides	188-195	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	111-114
29579062-5	2018	Considering that lectins exclusively recognize the oligosaccharide components of virus Env, these data suggest that glycan heterogeneity among HIV-1 isolates may explain this differential sensitivity.	Polysaccharides	116-122	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	87-90
29579062-7	2018	Viruses enriched for alpha1-2Man terminating Man5-9GlcNAc2 glycans became similarly sensitive to alpha1-2Man-binding lectins.	Polysaccharides	59-66	adrenoceptor alpha 1D	Homo sapiens	21-29
29579062-10	2018	In addition, while Env of viruses enriched with mannose-type glycans were sensitive to Endo-H deglycosylation, Env of untreated viruses were partially resistant, indicating that HIV-1 Env glycans are heterogeneously comprised of complex, hybrid, and mannose types.	Polysaccharides	61-68	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	19-22
29137479-3	2018	The study of the E-cadherin and the potassium channel to demonstrate how glycans affect the spatial arrangement, the stability and activity of the glycoproteins on the membranes.	Polysaccharides	73-80	cadherin 1	Homo sapiens	17-27
29443510-6	2018	The ability to obtain glycan structural details at the MS2 level, without permethylation, via a combination of fixed charge derivatization, EED, and de novo spectral interpretation, makes the present approach a promising tool for comprehensive and rapid characterization of glycan mixtures.	Polysaccharides	22-28	MS2	Homo sapiens	55-58
29477842-6	2018	Our data showed for the first time that endogenous fukutin and FKRP enzyme activities coexist with TMEM5 enzyme activity, and suggest the possibility that formation of this enzyme complex may contribute to specific and prompt biosynthesis of glycans that are required for dystroglycan function.	Polysaccharides	242-249	fukutin	Homo sapiens	51-58
29477842-6	2018	Our data showed for the first time that endogenous fukutin and FKRP enzyme activities coexist with TMEM5 enzyme activity, and suggest the possibility that formation of this enzyme complex may contribute to specific and prompt biosynthesis of glycans that are required for dystroglycan function.	Polysaccharides	242-249	fukutin related protein	Homo sapiens	63-67
29477842-6	2018	Our data showed for the first time that endogenous fukutin and FKRP enzyme activities coexist with TMEM5 enzyme activity, and suggest the possibility that formation of this enzyme complex may contribute to specific and prompt biosynthesis of glycans that are required for dystroglycan function.	Polysaccharides	242-249	ribitol xylosyltransferase 1	Homo sapiens	99-104
29477842-6	2018	Our data showed for the first time that endogenous fukutin and FKRP enzyme activities coexist with TMEM5 enzyme activity, and suggest the possibility that formation of this enzyme complex may contribute to specific and prompt biosynthesis of glycans that are required for dystroglycan function.	Polysaccharides	242-249	dystroglycan 1	Homo sapiens	272-284
29324282-4	2018	In this work, we explored the ability of the glycan chains to affect IgG1 interaction with two key receptor families, FcRn and gamma-type Fc receptors, as well as the influence of glycan composition on the conformation and stability of the antibody molecule.	Polysaccharides	45-51	Fc gamma receptor and transporter	Homo sapiens	118-122
29616041-1	2018	The composition of the conserved N297 glycan in immunoglobulin G (IgG) has been shown to affect antibody effector functions via C1q of the complement system and Fc gamma receptors (FcgammaR) on immune cells.	Polysaccharides	38-44	complement C1q A chain	Homo sapiens	128-131
29780528-0	2018	Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics.	Polysaccharides	10-16	toll like receptor 4	Homo sapiens	23-27
29780528-0	2018	Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics.	Polysaccharides	10-16	caspase 4	Homo sapiens	47-56
29780528-5	2018	We report the discovery of highly potent glycan-based immunostimulants with picomolar affinity for TLR4 which interact with caspase-4/11 and promote caspase-4/11 oligomerization while abolishing caspase-11 protease activity.	Polysaccharides	41-47	toll like receptor 4	Homo sapiens	99-103
29780528-5	2018	We report the discovery of highly potent glycan-based immunostimulants with picomolar affinity for TLR4 which interact with caspase-4/11 and promote caspase-4/11 oligomerization while abolishing caspase-11 protease activity.	Polysaccharides	41-47	caspase 4	Homo sapiens	124-133
29780528-5	2018	We report the discovery of highly potent glycan-based immunostimulants with picomolar affinity for TLR4 which interact with caspase-4/11 and promote caspase-4/11 oligomerization while abolishing caspase-11 protease activity.	Polysaccharides	41-47	caspase 4	Homo sapiens	149-158
29696074-3	2018	Through RNAi screening, we identified a novel EV uptake mechanism involving a triple interaction between the chemokine receptor CCR8 on the cells, glycans exposed on EVs and the soluble ligand CCL18.	Polysaccharides	147-154	C-C motif chemokine receptor 8	Homo sapiens	128-132
29370452-1	2018	The C-type lectins dectin-1 and dectin-2 contribute to innate immunity against microbial pathogens by recognizing their foreign glycan structures.	Polysaccharides	128-134	C-type lectin domain containing 7A	Homo sapiens	19-27
29370452-1	2018	The C-type lectins dectin-1 and dectin-2 contribute to innate immunity against microbial pathogens by recognizing their foreign glycan structures.	Polysaccharides	128-134	C-type lectin domain containing 6A	Homo sapiens	32-40
29530027-9	2018	METHODS: Firstly, the composition of polysaccharide fractions isolated from K. grandifoliola stem bark (KGF), C. sanguinolenta (CSF) and C. citratus (CCF) leaves was assessed.	Polysaccharides	37-51	fibroblast growth factor 7	Homo sapiens	104-107
29696074-3	2018	Through RNAi screening, we identified a novel EV uptake mechanism involving a triple interaction between the chemokine receptor CCR8 on the cells, glycans exposed on EVs and the soluble ligand CCL18.	Polysaccharides	147-154	C-C motif chemokine ligand 18	Homo sapiens	193-198
29530027-9	2018	METHODS: Firstly, the composition of polysaccharide fractions isolated from K. grandifoliola stem bark (KGF), C. sanguinolenta (CSF) and C. citratus (CCF) leaves was assessed.	Polysaccharides	37-51	colony stimulating factor 2	Homo sapiens	128-131
29420040-3	2018	The design of germline-targeting Env immunogens therefore includes the targeted deletion of specific glycan sites.	Polysaccharides	101-107	endogenous retrovirus group K member 20	Homo sapiens	33-36
29523693-2	2018	IgG glycosylation is known to impact antibody function, but the role of FcgammaRIIIA glycans, if any, is unclear.	Polysaccharides	85-92	Fc gamma receptor IIIa	Homo sapiens	72-84
29330305-7	2018	The changes in binding activity mirrored changes in NMR spectra of the two CD16a glycoforms, indicating that CD16a glycan composition also affects the glycoprotein"s structure.	Polysaccharides	115-121	Fc gamma receptor IIIa	Homo sapiens	75-80
29330305-7	2018	The changes in binding activity mirrored changes in NMR spectra of the two CD16a glycoforms, indicating that CD16a glycan composition also affects the glycoprotein"s structure.	Polysaccharides	115-121	Fc gamma receptor IIIa	Homo sapiens	109-114
29343613-0	2018	Restricted HIV-1 Env glycan engagement by lectin-reengineered DAVEI protein chimera is sufficient for lytic inactivation of the virus.	Polysaccharides	21-27	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	17-20
29343613-5	2018	MVN is a monovalent lectin with a single glycan-binding site in gp120, is structurally similar to CVN and exhibits no toxicity or mitogenicity, both of which are liabilities with CVN.	Polysaccharides	41-47	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	64-69
29343613-9	2018	That the lectin domain in DAVEIs can utilize MVN without loss of virolytic function argues that restricted HIV-1 Env (envelope glycoprotein) glycan engagement is sufficient for virolysis.	Polysaccharides	141-147	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	113-116
29343613-9	2018	That the lectin domain in DAVEIs can utilize MVN without loss of virolytic function argues that restricted HIV-1 Env (envelope glycoprotein) glycan engagement is sufficient for virolysis.	Polysaccharides	141-147	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	118-139
29513734-6	2018	The biochemical properties of TPO expressed in mammary cell lines and normal thyrocytes are similar regarding glycan content, molecular weight and isoelectric point.	Polysaccharides	110-116	thyroid peroxidase	Homo sapiens	30-33
29456142-5	2018	The presence of malectin-like domains in FER and related receptor kinases has led to widespread speculation that they interact with cell-wall polysaccharides and can potentially serve a wall-sensing function.	Polysaccharides	142-157	Malectin/receptor-like protein kinase family protein	Arabidopsis thaliana	41-44
29420040-4	2018	However, the processing of glycans on Env trimers can be influenced by the density with which they are packed together, a highly relevant point given the essential contributions under-processed glycans make to multiple bNAb epitopes.	Polysaccharides	27-34	endogenous retrovirus group K member 20	Homo sapiens	38-41
29420040-4	2018	However, the processing of glycans on Env trimers can be influenced by the density with which they are packed together, a highly relevant point given the essential contributions under-processed glycans make to multiple bNAb epitopes.	Polysaccharides	194-201	endogenous retrovirus group K member 20	Homo sapiens	38-41
29902864-0	2018	Protective effect of acidic polysaccharide from Schisandra chinensis on acute ethanol-induced liver injury through reducing CYP2E1-dependent oxidative stress.	Polysaccharides	28-42	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	124-130
29507546-0	2018	Glycan analysis of colorectal cancer samples reveals stage-dependent changes in CEA glycosylation patterns.	Polysaccharides	0-6	CEA cell adhesion molecule 3	Homo sapiens	80-83
29507546-7	2018	Conclusions: Our insights into the changing CEA glycosylation patterns and their role in the development of CRC highlight the importance of glycan variants on CEA for early clinical detection and staging of CRC.	Polysaccharides	140-146	CEA cell adhesion molecule 3	Homo sapiens	44-47
29507546-7	2018	Conclusions: Our insights into the changing CEA glycosylation patterns and their role in the development of CRC highlight the importance of glycan variants on CEA for early clinical detection and staging of CRC.	Polysaccharides	140-146	CEA cell adhesion molecule 3	Homo sapiens	159-162
29113893-2	2018	Human Intelectin-1 was previously reported to bind to microbial glycans via ribofuranoside or galactofuranoside residues, whereas subsequently, a crystal structure of ligand bound hITLN1 indicated that hITLN1 does not bind to ribofuranoside but distinguishes between microbial and human glycans through a glycan motif - a terminal, acyclic 1,2-diol, which is present on galactofuranose and other microbial saccharides.	Polysaccharides	64-71	intelectin 1	Homo sapiens	6-18
29306566-0	2018	Bispecific chimeric antigen receptors targeting the CD4 binding site and high-mannose Glycans of gp120 optimized for anti-human immunodeficiency virus potency and breadth with minimal immunogenicity.	Polysaccharides	86-93	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	97-102
29513319-5	2018	Two selenium (Se)-containing polysaccharides, Se-RLFP-1 and Se-RLFP-2, were isolated from R. laevigata fruit.	Polysaccharides	29-44	RLF pseudogene 1	Homo sapiens	49-55
29174358-3	2018	Here, an acidic polysaccharide designated LBP1B-S-2 with an average molecular weight of 80.00kDa, was extracted and purified from dried mature fruits of Lycium barbarum L. by DEAE Sepharose  Fast Flow and Sephacryl S-300 HR columns.	Polysaccharides	16-30	upstream binding protein 1	Homo sapiens	42-47
29280518-7	2018	At these concentrations of LA, 0.1% of polysaccharide showed a significant decrease in SP release from the two cellular types and in co-cultures without modifying the pH of the medium.	Polysaccharides	39-53	tachykinin precursor 1	Homo sapiens	87-89
29217185-0	2018	Selenizing astragalus polysaccharide attenuates PCV2 replication promotion caused by oxidative stress through autophagy inhibition via PI3K/AKT activation.	Polysaccharides	22-36	AKT serine/threonine kinase 1	Homo sapiens	140-143
29113893-2	2018	Human Intelectin-1 was previously reported to bind to microbial glycans via ribofuranoside or galactofuranoside residues, whereas subsequently, a crystal structure of ligand bound hITLN1 indicated that hITLN1 does not bind to ribofuranoside but distinguishes between microbial and human glycans through a glycan motif - a terminal, acyclic 1,2-diol, which is present on galactofuranose and other microbial saccharides.	Polysaccharides	287-294	intelectin 1	Homo sapiens	6-18
29113893-2	2018	Human Intelectin-1 was previously reported to bind to microbial glycans via ribofuranoside or galactofuranoside residues, whereas subsequently, a crystal structure of ligand bound hITLN1 indicated that hITLN1 does not bind to ribofuranoside but distinguishes between microbial and human glycans through a glycan motif - a terminal, acyclic 1,2-diol, which is present on galactofuranose and other microbial saccharides.	Polysaccharides	287-294	intelectin 1	Homo sapiens	202-208
29113893-2	2018	Human Intelectin-1 was previously reported to bind to microbial glycans via ribofuranoside or galactofuranoside residues, whereas subsequently, a crystal structure of ligand bound hITLN1 indicated that hITLN1 does not bind to ribofuranoside but distinguishes between microbial and human glycans through a glycan motif - a terminal, acyclic 1,2-diol, which is present on galactofuranose and other microbial saccharides.	Polysaccharides	64-70	intelectin 1	Homo sapiens	6-18
29113893-2	2018	Human Intelectin-1 was previously reported to bind to microbial glycans via ribofuranoside or galactofuranoside residues, whereas subsequently, a crystal structure of ligand bound hITLN1 indicated that hITLN1 does not bind to ribofuranoside but distinguishes between microbial and human glycans through a glycan motif - a terminal, acyclic 1,2-diol, which is present on galactofuranose and other microbial saccharides.	Polysaccharides	64-70	intelectin 1	Homo sapiens	202-208
29319921-3	2018	In the second dimension, a polysaccharide-coated enantioselective column, Chiralpak AD-H (2.0 x 250 mm, 5 mum), was used.	Polysaccharides	27-41	latexin	Homo sapiens	106-109
29138805-1	2018	The present study assessed the beneficial skeletal muscle-preserving effects of extracellular polysaccharides from Aureobasidium pullulans SM-2001 (Polycan) (EAP) on dexamethasone (DEXA)-induced catabolic muscle atrophy in mice.	Polysaccharides	94-109	glutamyl aminopeptidase	Mus musculus	158-161
29128671-0	2018	Identification of dominant anti-glycan IgE responses in school children by glycan microarray.	Polysaccharides	32-38	immunoglobulin heavy constant epsilon	Homo sapiens	39-42
29128671-0	2018	Identification of dominant anti-glycan IgE responses in school children by glycan microarray.	Polysaccharides	75-81	immunoglobulin heavy constant epsilon	Homo sapiens	39-42
29182943-5	2018	Additionally, sperm were analyzed for motility characteristics, acrosome status, and binding to the two oviduct glycan motifs that bind porcine sperm, biantennary 6-sialylated N-acetyllactosamine on a mannose core (bi-SiaLN) and sulfated LeX trisaccharide (suLeX).	Polysaccharides	112-118	fucosyltransferase 4	Homo sapiens	238-241
29374074-2	2018	CD22-/- mice generate significantly impaired Ab responses to T cell-independent type 2 (TI-2) Ags, including haptenated Ficoll and pneumococcal polysaccharides, Ags that elicit poor T cell help and activate BCR signaling via multivalent epitope crosslinking.	Polysaccharides	144-159	CD22 antigen	Mus musculus	0-4
29416134-4	2018	The acquisition of variable domain glycans, in fact, could enable ACPA-expressing B cells to breach tolerance.	Polysaccharides	35-42	proteinase 3	Homo sapiens	66-70
29328525-0	2018	Role of sialic acid-containing glycans of matrix metalloproteinase-9 (MMP-9) in the interaction between MMP-9 and staphylococcal superantigen-like protein 5.	Polysaccharides	31-38	matrix metallopeptidase 9	Homo sapiens	42-68
29328525-0	2018	Role of sialic acid-containing glycans of matrix metalloproteinase-9 (MMP-9) in the interaction between MMP-9 and staphylococcal superantigen-like protein 5.	Polysaccharides	31-38	matrix metallopeptidase 9	Homo sapiens	70-75
29328525-0	2018	Role of sialic acid-containing glycans of matrix metalloproteinase-9 (MMP-9) in the interaction between MMP-9 and staphylococcal superantigen-like protein 5.	Polysaccharides	31-38	matrix metallopeptidase 9	Homo sapiens	104-109
29328525-3	2018	These interactions were suggested to depend on sialic acid-containing glycans of MMP-9, but the roles of sialic acids in the interaction between SSL5 and MMP-9 are still controversial.	Polysaccharides	70-77	matrix metallopeptidase 9	Homo sapiens	81-86
29286151-0	2018	Polysaccharide sulphated derivative from Aconitum coreanum induces cell apoptosis in the human brain glioblastoma U87MG cell line via the NF-kappaB/Bcl-2 cell apoptotic signaling pathway.	Polysaccharides	0-14	nuclear factor kappa B subunit 1	Homo sapiens	138-147
29286151-0	2018	Polysaccharide sulphated derivative from Aconitum coreanum induces cell apoptosis in the human brain glioblastoma U87MG cell line via the NF-kappaB/Bcl-2 cell apoptotic signaling pathway.	Polysaccharides	0-14	BCL2 apoptosis regulator	Homo sapiens	148-153
29286151-1	2018	In a previous study, our team preliminarily investigated the bioefficacy of an extracted polysaccharide from the medicinal plant Aconitum coreanum (ACP1).	Polysaccharides	89-103	acid phosphatase 1	Homo sapiens	148-152
29467867-0	2018	Low-molecular-weight polysaccharides from Agaricus blazei Murrill modulate the Th1 response in cancer immunity.	Polysaccharides	21-36	negative elongation factor complex member C/D, Th1l	Mus musculus	79-82
29467867-1	2018	To assess the effect of low-molecular-weight polysaccharides from Agaricus blazei Murrill (ABP-AW1) as an immunoadjuvant therapy for type 1 T-helper (Th1) responses in tumorigenesis, C57BL/6 mice were inoculated subcutaneously with ovalbumin (E.G7-OVA).	Polysaccharides	45-60	negative elongation factor complex member C/D, Th1l	Mus musculus	150-153
29491407-6	2018	Using this platform, high-affinity glycan ligands are discovered for Siglec-15-a sialic acid-binding lectin involved in osteoclast differentiation.	Polysaccharides	35-41	sialic acid binding Ig like lectin 15	Homo sapiens	69-78
29595154-4	2018	The FO membrane fouling layer mainly consisted of organic substances like polysaccharides and proteins, and was very loose and could be effectively removed by rinsing the membrane surface with tap water.	Polysaccharides	74-89	nuclear RNA export factor 1	Homo sapiens	193-196
29474444-4	2018	One autologous NAb epitope on the BG505 Env trimer is known to involve residues lining a hole in the glycan shield that is blocked by adding a glycan at either residue 241 or 289.	Polysaccharides	101-107	endogenous retrovirus group K member 20	Homo sapiens	40-43
29474444-4	2018	One autologous NAb epitope on the BG505 Env trimer is known to involve residues lining a hole in the glycan shield that is blocked by adding a glycan at either residue 241 or 289.	Polysaccharides	143-149	endogenous retrovirus group K member 20	Homo sapiens	40-43
29474444-7	2018	A frequently immunogenic epitope in rabbits is blocked by adding a glycan at residue 465 near the junction of the gp120 V5 loop and beta24 strand and is influenced by amino-acid changes in the structurally nearby C3 region.	Polysaccharides	67-73	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	114-119
29237123-12	2018	We demonstrate that the glycan epitopes of heterofunctional conjugates engage and cluster target B-cell receptors and CD22 receptors on B cells, supporting the application of these reagents for investigating cellular response to carbohydrate antigens of the ABO blood group system.	Polysaccharides	24-30	CD22 molecule	Homo sapiens	118-122
29237123-12	2018	We demonstrate that the glycan epitopes of heterofunctional conjugates engage and cluster target B-cell receptors and CD22 receptors on B cells, supporting the application of these reagents for investigating cellular response to carbohydrate antigens of the ABO blood group system.	Polysaccharides	24-30	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	258-261
29487346-6	2018	Analyses of lectin binding and expression of glucosaminyl- and sialyltransferases indicated that the glycan composition on the cell surface of Sertoli and peritubular cells becomes less favourable for Gal-1 binding under inflammatory conditions.	Polysaccharides	101-107	galectin 1	Rattus norvegicus	201-206
29527188-0	2018	Polysaccharide IV from Lycium barbarum L. Improves Lipid Profiles of Gestational Diabetes Mellitus of Pregnancy by Upregulating ABCA1 and Downregulating Sterol Regulatory Element-Binding Transcription 1 via miR-33.	Polysaccharides	0-14	microRNA 33a	Homo sapiens	207-213
29384548-6	2018	Thus, SHIP-1 and 2 significantly improved the immune response through the intragastric administration of the tested high dosages by increasing the production of cytokines in the healthy mice, and these polysaccharides could possibly be used as an immunopotentiator in health foods or dietary supplements.	Polysaccharides	202-217	inositol polyphosphate-5-phosphatase D	Mus musculus	6-18
29491407-7	2018	Incubating human osteoprogenitor cells with cells displaying a high-affinity Siglec-15 ligand impairs osteoclast differentiation, demonstrating the utility of this cell-based glycan array technology.	Polysaccharides	175-181	sialic acid binding Ig like lectin 15	Homo sapiens	77-86
29545735-2	2018	Objective: The objective of the present study was to investigate the tumor-suppressive activity and mechanism of a novel polysaccharide (SAP) extracted from Sarcodon aspratus.	Polysaccharides	121-135	SH2 domain containing 1A	Homo sapiens	137-140
29491415-4	2018	Here, we report the use of tandem single-chain variable fragment (ScFv) domains of two bNAbs, specific for the CD4-binding site and V3 glycan patch, to form anti-HIV-1 bispecific ScFvs (Bi-ScFvs).	Polysaccharides	135-141	immunglobulin heavy chain variable region	Homo sapiens	66-70
29419740-2	2018	Tea polysaccharide (TPS) is the major bioactive component in green tea, it has showed antioxidant, antitumor and anti-inflammatory bioactivities.	Polysaccharides	4-18	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	0-3
29432456-3	2018	Using flow cytometric analysis of primary human jejunal epithelial cells and granulocytes, we now show that CTB binding correlates with expression of the fucosylated Lewis X (LeX) glycan.	Polysaccharides	180-186	phosphate cytidylyltransferase 1B, choline	Homo sapiens	108-111
29432456-3	2018	Using flow cytometric analysis of primary human jejunal epithelial cells and granulocytes, we now show that CTB binding correlates with expression of the fucosylated Lewis X (LeX) glycan.	Polysaccharides	180-186	fucosyltransferase 4	Homo sapiens	175-178
29432456-5	2018	CTB binds the LeX glycan in vitro when this moiety is linked to proteins but not to ceramides, and this binding can be blocked by mAb to LeX.	Polysaccharides	18-24	phosphate cytidylyltransferase 1B, choline	Homo sapiens	0-3
29432456-5	2018	CTB binds the LeX glycan in vitro when this moiety is linked to proteins but not to ceramides, and this binding can be blocked by mAb to LeX.	Polysaccharides	18-24	fucosyltransferase 4	Homo sapiens	14-17
29432456-5	2018	CTB binds the LeX glycan in vitro when this moiety is linked to proteins but not to ceramides, and this binding can be blocked by mAb to LeX.	Polysaccharides	18-24	fucosyltransferase 4	Homo sapiens	137-140
29419740-2	2018	Tea polysaccharide (TPS) is the major bioactive component in green tea, it has showed antioxidant, antitumor and anti-inflammatory bioactivities.	Polysaccharides	4-18	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	67-70
29467575-0	2018	Nanoscale polysaccharide derivative as an AEG-1 siRNA carrier for effective osteosarcoma therapy.	Polysaccharides	10-24	metadherin	Mus musculus	42-47
29254034-3	2018	Based on FT-IR, NMR, and methylation analysis, REPS2-A was identified to be a highly branched polysaccharide with a backbone of (1 3)-linkedGal with Man, Gal, and Ara terminals.	Polysaccharides	94-108	RALBP1 associated Eps domain containing 2	Homo sapiens	47-52
29103194-12	2018	CONCLUSIONS: Astragalus polysaccharides increased the sensitivity of SKOV3 cells to cisplatin potentially by activating the JNK pathway.	Polysaccharides	24-39	mitogen-activated protein kinase 8	Homo sapiens	124-127
29288201-3	2018	Because all cells display sialic acids, and CD22 and Siglec-G have distinct, yet overlapping, specificities for sialic acid-containing glycan ligands, any cell could, in principle, invoke this tolerogenic mechanism for cell surface Ags.	Polysaccharides	135-141	CD22 antigen	Mus musculus	44-48
29149729-4	2018	Nevertheless, naturally available glycoproteins, such as ovalbumin in chicken egg whites, are good sources for fabricating glycan-immobilized nanoprobes.	Polysaccharides	123-129	ovalbumin (SERPINB14)	Gallus gallus	57-66
29149729-6	2018	The generated Au@cew NPs are mainly encapsulated by ovalbumin, in which the surface is decorated by abundant hybrid mannose and Galbeta(1 4)GlcNAc-terminated glycan ligands.	Polysaccharides	158-164	ovalbumin (SERPINB14)	Gallus gallus	52-61
28870748-0	2018	Sulfated polysaccharide of Sepiella Maindroni ink inhibits the migration, invasion and matrix metalloproteinase-2 expression through suppressing EGFR-mediated p38/MAPK and PI3K/Akt/mTOR signaling pathways in SKOV-3 cells.	Polysaccharides	9-23	epidermal growth factor receptor	Homo sapiens	145-149
28870748-0	2018	Sulfated polysaccharide of Sepiella Maindroni ink inhibits the migration, invasion and matrix metalloproteinase-2 expression through suppressing EGFR-mediated p38/MAPK and PI3K/Akt/mTOR signaling pathways in SKOV-3 cells.	Polysaccharides	9-23	mitogen-activated protein kinase 14	Homo sapiens	159-162
28870748-0	2018	Sulfated polysaccharide of Sepiella Maindroni ink inhibits the migration, invasion and matrix metalloproteinase-2 expression through suppressing EGFR-mediated p38/MAPK and PI3K/Akt/mTOR signaling pathways in SKOV-3 cells.	Polysaccharides	9-23	AKT serine/threonine kinase 1	Homo sapiens	177-180
28870748-0	2018	Sulfated polysaccharide of Sepiella Maindroni ink inhibits the migration, invasion and matrix metalloproteinase-2 expression through suppressing EGFR-mediated p38/MAPK and PI3K/Akt/mTOR signaling pathways in SKOV-3 cells.	Polysaccharides	9-23	mechanistic target of rapamycin kinase	Homo sapiens	181-185
28923567-1	2018	PTP, one polysaccharide extracted from the roots of Polygala tenuifolia, has displayed anti-cancer activity in several types of ovarian cancer cells.	Polysaccharides	9-23	protein tyrosine phosphatase receptor type U	Homo sapiens	0-3
29214724-0	2018	CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation.	Polysaccharides	15-29	nitric oxide synthase 2, inducible	Mus musculus	42-46
29434755-2	2018	However, the association between the antitumour and immunostimulatory activities of polysaccharide extracted from A. senticosus (ASPS) remains to be elucidated.	Polysaccharides	84-98	alveolar soft part sarcoma chromosome region, candidate 1 (human)	Mus musculus	129-133
29434755-3	2018	The aim of the present study was to investigate the anti-tumour and immunomodulatory effects of polysaccharide extracted from ASPS on Crocker sarcoma S180, hepatic carcinoma H22 and uterine cervical carcinoma U14 tumour cell lines implanted in mice.	Polysaccharides	96-110	alveolar soft part sarcoma chromosome region, candidate 1 (human)	Mus musculus	126-130
29337342-4	2018	These 3 polysaccharides also reduced pharmacokinetic parameters, that is, Cmax , AUC0-t , and AUC0-  , after Trp-P-1 was given to rats intragastrically.	Polysaccharides	8-23	polycystin 1, transient receptor potential channel interacting	Homo sapiens	109-116
29337342-6	2018	The Ames test showed that these 3 polysaccharides reduced Trp-P-1 mutagenicity to Salmonella typhimurium TA98, but gum arabic did not.	Polysaccharides	34-49	polycystin 1, transient receptor potential channel interacting	Homo sapiens	58-65
29337342-7	2018	Isothermal titration calorimetry assay indicated that Trp-P-1 interacted with these 3 polysaccharides.	Polysaccharides	86-101	polycystin 1, transient receptor potential channel interacting	Homo sapiens	54-61
29337342-8	2018	Thermodynamic study showed that the actual value of  H &lt;0, but its absolute value greater than the corresponding value of T S, suggest a specific interaction between Trp-P-1 and these 3 polysaccharides, probably through the hydrogen bond and/or ion interaction.	Polysaccharides	189-204	polycystin 1, transient receptor potential channel interacting	Homo sapiens	169-176
29288201-3	2018	Because all cells display sialic acids, and CD22 and Siglec-G have distinct, yet overlapping, specificities for sialic acid-containing glycan ligands, any cell could, in principle, invoke this tolerogenic mechanism for cell surface Ags.	Polysaccharides	135-141	sialic acid binding Ig-like lectin G	Mus musculus	53-61
29079498-2	2018	The diversity and importance of these surface glycans can be seen in individuals who lack a functional copy of the fucosyltransferase gene, FUT2.	Polysaccharides	46-53	fucosyltransferase 2	Homo sapiens	140-144
29268168-3	2018	The increase in affinity for afucosylated IgG has previously been shown to depend on direct carbohydrate-carbohydrate interactions between the IgG-Fc glycan with an N-linked glycan at position 162 unique to hFcgammaRIIIa and hFcgammaRIIIb.	Polysaccharides	150-156	Fc gamma receptor IIIa	Homo sapiens	207-238
29230084-3	2018	Ionizing radiation causes significant break down of the polysaccharide and leads to the production of potentially useful gaseous products such as H2 and CO.	Polysaccharides	56-70	relaxin 2	Homo sapiens	146-155
29079498-4	2018	The mediation of host-pathogen interactions by mucosal glycans, such as those added by FUT2, is poorly understood.	Polysaccharides	55-62	fucosyltransferase 2	Homo sapiens	87-91
29600645-2	2018	To clarify and complete the biosynthetic pathway of polysaccharide, the GAPDH gene in Codonopsis pilosula, named CpGAPDH, was cloned according to the transcriptome of pilosula, using the GAPDH gene in potato as query.	Polysaccharides	52-66	glyceraldehyde-3-phosphate dehydrogenase	Solanum tuberosum	72-77
29324290-3	2018	Using a panel of RRV mutants lacking the envelope N-linked glycans, we found that MBL deposition onto infected cells was dependent on the E2 glycans.	Polysaccharides	59-66	mannose binding lectin 2	Homo sapiens	82-85
29600645-2	2018	To clarify and complete the biosynthetic pathway of polysaccharide, the GAPDH gene in Codonopsis pilosula, named CpGAPDH, was cloned according to the transcriptome of pilosula, using the GAPDH gene in potato as query.	Polysaccharides	52-66	glyceraldehyde-3-phosphate dehydrogenase	Solanum tuberosum	115-120
29385708-6	2018	While localization and trafficking of the camel and human HSPs revealed similar cytosolic localization, we could demonstrate altered glycan structure between camel and human HSPA6.	Polysaccharides	133-139	heat shock protein family A (Hsp70) member 6	Homo sapiens	174-179
28965048-3	2018	This strategy was characterized by the design of C21 steroidal skeleton, substituent group and glycan chain in an orderly way, which could quickly and efficiently screen the interested precursor ions.	Polysaccharides	95-101	TBL1X/Y related 1	Homo sapiens	49-52
29721409-3	2018	Here, glutathione (GSH)-activated light-up peptide-polysaccharide-inter-polyelectrolyte nanocomplexes are established through self-assembly of carboxymethyl dextran with disulfide-bridged ("S-S") oligoarginine peptide (S-Arg4), in which microRNA-34a (miR-34a) and indocyanine green (ICG) are simultaneously embedded and the nanocomplexes are subsequently stabilized by intermolecular cross-linking.	Polysaccharides	51-65	microRNA 34a	Homo sapiens	251-258
29403469-4	2017	E-selectin is inducibly expressed by cytokines (tumor necrosis factor-alpha and IL-1beta) on inflamed endothelium, and binds to sialofucosylated glycan determinants displayed on protein and lipid scaffolds of blood cells.	Polysaccharides	145-151	selectin E	Homo sapiens	0-10
29187599-4	2018	Here, we show that Asn-110 in native hDAO from amniotic fluid and Caco-2 cells, DAO from porcine kidneys, and rhDAO produced in two different HEK293 cell lines is also consistently occupied by oligomannosidic glycans.	Polysaccharides	209-216	D-amino acid oxidase	Homo sapiens	38-41
29721409-3	2018	Here, glutathione (GSH)-activated light-up peptide-polysaccharide-inter-polyelectrolyte nanocomplexes are established through self-assembly of carboxymethyl dextran with disulfide-bridged ("S-S") oligoarginine peptide (S-Arg4), in which microRNA-34a (miR-34a) and indocyanine green (ICG) are simultaneously embedded and the nanocomplexes are subsequently stabilized by intermolecular cross-linking.	Polysaccharides	51-65	microRNA 34a	Homo sapiens	237-249
29342882-9	2018	Siglec-9 is one of Siglecs and capsular polysaccharide (CPS) of group B Streptococcus (GBS) binds to Siglec-9 on neutrophils, leading to suppress host immune response and provide a survival advantage to the pathogen.	Polysaccharides	40-54	sialic acid binding Ig-like lectin E	Mus musculus	0-8
29342882-9	2018	Siglec-9 is one of Siglecs and capsular polysaccharide (CPS) of group B Streptococcus (GBS) binds to Siglec-9 on neutrophils, leading to suppress host immune response and provide a survival advantage to the pathogen.	Polysaccharides	40-54	sialic acid binding Ig-like lectin E	Mus musculus	101-109
29249538-10	2018	In this work, we utilize AF4-MALS-dRI to separate and analyze binary mixtures of the well-known polysaccharides pullulan and glycogen, or pullulan and poly(ethylene oxide), respectively, in solution.	Polysaccharides	96-111	AF4/FMR2 family member 1	Homo sapiens	25-28
29146181-6	2018	Molecules including CD22, CD45 and IgM were labeled in wild-type but not ST6GalI-/- B cells that lack alpha2,6 sialic acids, indicating that these molecules associate with CD22 by lectin-glycan interaction, and are therefore cis-ligands.	Polysaccharides	187-193	CD22 antigen	Mus musculus	172-176
29249538-10	2018	In this work, we utilize AF4-MALS-dRI to separate and analyze binary mixtures of the well-known polysaccharides pullulan and glycogen, or pullulan and poly(ethylene oxide), respectively, in solution.	Polysaccharides	96-111	natural cytotoxicity triggering receptor 3	Homo sapiens	29-33
29129073-2	2018	We previously reported the development of a molecularly bottom-up approach to plasma and serum (P/S) glycomics based on glycan linkage analysis that captures features such as alpha2-6 sialylation, beta1-6 branching, and core fucosylation as single analytical signals.	Polysaccharides	120-126	immunoglobulin binding protein 1	Homo sapiens	175-183
29129073-2	2018	We previously reported the development of a molecularly bottom-up approach to plasma and serum (P/S) glycomics based on glycan linkage analysis that captures features such as alpha2-6 sialylation, beta1-6 branching, and core fucosylation as single analytical signals.	Polysaccharides	120-126	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	197-204
29164281-8	2018	Released native glycans were purified and enriched by PGC-SPE.	Polysaccharides	16-23	progastricsin	Rattus norvegicus	54-57
29146181-8	2018	Thus, the lectin-glycan interaction recruits cis-ligands already located in the relative proximity of CD22 through non-lectin-glycan interaction to the close proximity.	Polysaccharides	17-23	CD22 antigen	Mus musculus	102-106
29146181-8	2018	Thus, the lectin-glycan interaction recruits cis-ligands already located in the relative proximity of CD22 through non-lectin-glycan interaction to the close proximity.	Polysaccharides	126-132	CD22 antigen	Mus musculus	102-106
30504678-8	2018	These results indicate that asiatic acid, corosolic acid, and maslinic acid interfere with the intracellular transport of ICAM-1 to the cell surface and cause the accumulation of ICAM-1 linked to endoglycosidase H-sensitive glycans.	Polysaccharides	224-231	intercellular adhesion molecule 1	Homo sapiens	122-128
30504678-8	2018	These results indicate that asiatic acid, corosolic acid, and maslinic acid interfere with the intracellular transport of ICAM-1 to the cell surface and cause the accumulation of ICAM-1 linked to endoglycosidase H-sensitive glycans.	Polysaccharides	224-231	intercellular adhesion molecule 1	Homo sapiens	179-185
30504678-4	2018	Endoglycosidase H-sensitive glycans were linked to ICAM-1 in asiatic acid-, corosolic acid-, and maslinic acid-treated cells.	Polysaccharides	28-35	intercellular adhesion molecule 1	Homo sapiens	51-57
28797815-0	2018	Structure of a pectic polysaccharide from Pseudostellaria heterophylla and stimulating insulin secretion of INS-1 cell and distributing in rats by oral.	Polysaccharides	22-36	insulin 1	Rattus norvegicus	108-113
30196291-0	2018	Novel Polysaccharide H-1-2 from Pseudostellaria Heterophylla Alleviates Type 2 Diabetes Mellitus.	Polysaccharides	6-20	H1.5 linker histone, cluster member	Homo sapiens	21-26
30196291-1	2018	BACKGROUND/AIMS: To investigate the potential therapeutic effect of novel polysaccharide H-1-2 from pseudostellaria heterophylla against type 2 Diabetes Mellitus (T2DM) and elucidate the underling molecular mechanisms.	Polysaccharides	74-88	H1.5 linker histone, cluster member	Homo sapiens	89-94
28432527-0	2018	Effects of Agaricus blazei Murill Polysaccharide on Cadmium Poisoning on the MDA5 Signaling Pathway and Antioxidant Function of Chicken Peripheral Blood Lymphocytes.	Polysaccharides	34-48	interferon induced with helicase C domain 1	Gallus gallus	77-81
30562752-7	2018	RESULTS: CGD polysaccharide significantly inhibited LPS-induced NO production and PGE2 expression by reducing the expression of iNOS and COX-2.	Polysaccharides	13-27	nitric oxide synthase 2, inducible	Mus musculus	128-132
30562752-7	2018	RESULTS: CGD polysaccharide significantly inhibited LPS-induced NO production and PGE2 expression by reducing the expression of iNOS and COX-2.	Polysaccharides	13-27	cytochrome c oxidase II, mitochondrial	Mus musculus	137-142
30562752-9	2018	Further experiments demonstrated that CGD polysaccharide could inhibit inflammatory signaling pathways (the MAPK/NF-kappaB, PI3K/AKT/JNK and JAK/STAT pathways).	Polysaccharides	42-56	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-122
30562752-9	2018	Further experiments demonstrated that CGD polysaccharide could inhibit inflammatory signaling pathways (the MAPK/NF-kappaB, PI3K/AKT/JNK and JAK/STAT pathways).	Polysaccharides	42-56	thymoma viral proto-oncogene 1	Mus musculus	129-132
30562752-9	2018	Further experiments demonstrated that CGD polysaccharide could inhibit inflammatory signaling pathways (the MAPK/NF-kappaB, PI3K/AKT/JNK and JAK/STAT pathways).	Polysaccharides	42-56	mitogen-activated protein kinase 8	Mus musculus	133-136
30562752-13	2018	This effect lies in its regulatory effects on the signaling pathways MAPK/ NF-kappaB, PI3K/AKT/JNK, JAK/STAT and Nrf2/HO-1.Our findings reveal that CGD polysaccharide has the potential to be used as a relatively safe and effective drug as part of the treatment of NCDs.	Polysaccharides	152-166	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-84
30562752-13	2018	This effect lies in its regulatory effects on the signaling pathways MAPK/ NF-kappaB, PI3K/AKT/JNK, JAK/STAT and Nrf2/HO-1.Our findings reveal that CGD polysaccharide has the potential to be used as a relatively safe and effective drug as part of the treatment of NCDs.	Polysaccharides	152-166	thymoma viral proto-oncogene 1	Mus musculus	91-94
30562752-13	2018	This effect lies in its regulatory effects on the signaling pathways MAPK/ NF-kappaB, PI3K/AKT/JNK, JAK/STAT and Nrf2/HO-1.Our findings reveal that CGD polysaccharide has the potential to be used as a relatively safe and effective drug as part of the treatment of NCDs.	Polysaccharides	152-166	mitogen-activated protein kinase 8	Mus musculus	95-98
30562752-13	2018	This effect lies in its regulatory effects on the signaling pathways MAPK/ NF-kappaB, PI3K/AKT/JNK, JAK/STAT and Nrf2/HO-1.Our findings reveal that CGD polysaccharide has the potential to be used as a relatively safe and effective drug as part of the treatment of NCDs.	Polysaccharides	152-166	nuclear factor, erythroid derived 2, like 2	Mus musculus	113-117
30562752-13	2018	This effect lies in its regulatory effects on the signaling pathways MAPK/ NF-kappaB, PI3K/AKT/JNK, JAK/STAT and Nrf2/HO-1.Our findings reveal that CGD polysaccharide has the potential to be used as a relatively safe and effective drug as part of the treatment of NCDs.	Polysaccharides	152-166	heme oxygenase 1	Mus musculus	118-122
28882619-8	2018	More than 90% of ACPA-IgG molecules carry Fab glycans that are highly sialylated.	Polysaccharides	46-53	proteinase 3	Homo sapiens	17-21
28882619-8	2018	More than 90% of ACPA-IgG molecules carry Fab glycans that are highly sialylated.	Polysaccharides	46-53	FA complementation group B	Homo sapiens	42-45
28818727-8	2018	In vivo and in vitro experiments have demonstrated the ability of polysaccharide-rich extracts to provide neuroprotective effects through promotion of neurite outgrowth, and NF-kappaB, PI3K/Akt, MAPK, Nrf2/HO-1 signaling pathways.	Polysaccharides	66-80	AKT serine/threonine kinase 1	Homo sapiens	190-193
28818727-8	2018	In vivo and in vitro experiments have demonstrated the ability of polysaccharide-rich extracts to provide neuroprotective effects through promotion of neurite outgrowth, and NF-kappaB, PI3K/Akt, MAPK, Nrf2/HO-1 signaling pathways.	Polysaccharides	66-80	NFE2 like bZIP transcription factor 2	Homo sapiens	201-205
28818727-8	2018	In vivo and in vitro experiments have demonstrated the ability of polysaccharide-rich extracts to provide neuroprotective effects through promotion of neurite outgrowth, and NF-kappaB, PI3K/Akt, MAPK, Nrf2/HO-1 signaling pathways.	Polysaccharides	66-80	heme oxygenase 1	Homo sapiens	206-210
29451405-0	2018	Astragalus polysaccharide alleviates LPS-induced inflammation injury by regulating miR-127 in H9c2 cardiomyoblasts.	Polysaccharides	11-25	microRNA 127	Rattus norvegicus	83-90
29926407-1	2018	Tumor-associated gangliosides play important roles in regulation of signal transduction induced by growth-factor receptors including EGFR, FGFR, HGF and PDGFR in a specific microdomain called glycosynapse in the cancer cell membranes, and in interaction with glycan recognition molecules involved in cell adhesion and immune regulation including selectins and siglecs.	Polysaccharides	259-265	epidermal growth factor receptor	Homo sapiens	133-137
29926407-1	2018	Tumor-associated gangliosides play important roles in regulation of signal transduction induced by growth-factor receptors including EGFR, FGFR, HGF and PDGFR in a specific microdomain called glycosynapse in the cancer cell membranes, and in interaction with glycan recognition molecules involved in cell adhesion and immune regulation including selectins and siglecs.	Polysaccharides	259-265	platelet derived growth factor receptor beta	Homo sapiens	153-158
27643667-14	2018	Deglycosylated MPO presented less antigenicity to MPO-ANCA, which indicated the contribution of glycans to MPO epitopes.	Polysaccharides	96-103	myeloperoxidase	Homo sapiens	15-18
28971586-9	2018	The isolated glycans from bLF inhibit TLR-8.	Polysaccharides	13-20	toll-like receptor 8	Bos taurus	38-43
28721502-1	2018	Mucus production is initiated before birth and provides mucin glycans to the infant gut microbiota.	Polysaccharides	62-69	LOC100508689	Homo sapiens	56-61
27643667-5	2018	METHODS: We used eight glycosidases to remove different glycans on MPO separately.	Polysaccharides	56-63	myeloperoxidase	Homo sapiens	67-70
27643667-14	2018	Deglycosylated MPO presented less antigenicity to MPO-ANCA, which indicated the contribution of glycans to MPO epitopes.	Polysaccharides	96-103	myeloperoxidase	Homo sapiens	50-53
27643667-14	2018	Deglycosylated MPO presented less antigenicity to MPO-ANCA, which indicated the contribution of glycans to MPO epitopes.	Polysaccharides	96-103	myeloperoxidase	Homo sapiens	50-53
30996485-6	2018	Results: The most effective polysaccharides identified from this survey included chitosan, beta-1,3-glucan, gum tragacanth, xanthan and xyloglucan.	Polysaccharides	28-43	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	91-99
28855426-0	2017	Neural differentiation of fibroblasts induced by intracellular co-delivery of Ascl1, Brn2 and FoxA1 via a non-viral vector of cationic polysaccharide.	Polysaccharides	135-149	forkhead box A1	Mus musculus	94-99
30504657-2	2018	It belongs to the rhamnose-binding lectin family that binds to Gb3 glycan (Galalpha1-4Galbeta1-4Glc).	Polysaccharides	67-73	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	63-66
29892558-0	2018	Glycan binding profile of a fucolectin-related protein (FRP) encoded by the SP2159 gene of Streptococcus pneumoniae.	Polysaccharides	0-6	secreted frizzled related protein 1	Homo sapiens	56-59
29281818-4	2017	Env immunization of CD4bs bnAb heavy chain rearrangement (VHDJH) knockin mice similarly induced V1V2-glycan neutralizing antibodies (nAbs), wherein the human CD4bs VH chains were replaced with mouse rearrangements bearing diversity region (D)-D fusions, creating antibodies with long, tyrosine-rich HCDR3s.	Polysaccharides	101-107	melanoma antigen	Mus musculus	0-3
29281818-4	2017	Env immunization of CD4bs bnAb heavy chain rearrangement (VHDJH) knockin mice similarly induced V1V2-glycan neutralizing antibodies (nAbs), wherein the human CD4bs VH chains were replaced with mouse rearrangements bearing diversity region (D)-D fusions, creating antibodies with long, tyrosine-rich HCDR3s.	Polysaccharides	101-107	CD4 antigen	Mus musculus	20-23
29033318-3	2017	Here, we focus on a fucose analog with an alkyne group, 6-alkynyl-fucose (6-Alk-Fuc), which is used widely as a detection probe for fucosylated glycans, but is also suggested for use as a fucosylation inhibitor.	Polysaccharides	144-151	ALK receptor tyrosine kinase	Homo sapiens	76-79
29107699-6	2017	Rabbit immunization revealed that the synthetic self-adjuvant glycopeptide could elicit substantial glycan-dependent antibodies that exhibited broader recognition of HIV-1 gp120s than the non-glycosylated V3 peptide.	Polysaccharides	100-106	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	172-177
29033318-4	2017	Our glycan analysis using lectin and mass spectrometry demonstrated that 6-Alk-Fuc is a potent and general inhibitor of cellular fucosylation, with much higher potency than the existing inhibitor, 2-fluoro-fucose (2-F-Fuc).	Polysaccharides	4-10	ALK receptor tyrosine kinase	Homo sapiens	75-78
29210428-0	2017	Lectin-gated and glycan functionalized mesoporous silica nanocontainers for targeting cancer cells overexpressing Lewis X antigen.	Polysaccharides	17-23	fucosyltransferase 4	Homo sapiens	114-121
29348821-1	2017	Humans have circulating antibodies against diverse glycans containing N-glycolylneuraminic acid (Neu5Gc) due to function-loss mutation of the CMAH gene.	Polysaccharides	51-58	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	142-146
29246138-13	2017	The polysaccharides also affected the production of various cytokines, by increasing IL 2, IL 6, IL 7 levels and a decreasing TNFalpha levels.	Polysaccharides	4-19	interleukin 2	Mus musculus	85-89
29246138-13	2017	The polysaccharides also affected the production of various cytokines, by increasing IL 2, IL 6, IL 7 levels and a decreasing TNFalpha levels.	Polysaccharides	4-19	interleukin 6	Mus musculus	91-95
29246138-13	2017	The polysaccharides also affected the production of various cytokines, by increasing IL 2, IL 6, IL 7 levels and a decreasing TNFalpha levels.	Polysaccharides	4-19	interleukin 7	Mus musculus	97-101
29246138-13	2017	The polysaccharides also affected the production of various cytokines, by increasing IL 2, IL 6, IL 7 levels and a decreasing TNFalpha levels.	Polysaccharides	4-19	tumor necrosis factor	Mus musculus	126-134
29246138-16	2017	Furthermore, the polysaccharides enhance the levels of serum antitumor cytokines, IL 2, IL 6 and IL 7 while decreasing pro-tumor cytokine TNFalpha.	Polysaccharides	17-32	interleukin 2	Mus musculus	82-86
29246138-16	2017	Furthermore, the polysaccharides enhance the levels of serum antitumor cytokines, IL 2, IL 6 and IL 7 while decreasing pro-tumor cytokine TNFalpha.	Polysaccharides	17-32	interleukin 6	Mus musculus	88-92
29246138-16	2017	Furthermore, the polysaccharides enhance the levels of serum antitumor cytokines, IL 2, IL 6 and IL 7 while decreasing pro-tumor cytokine TNFalpha.	Polysaccharides	17-32	interleukin 7	Mus musculus	97-101
29246138-16	2017	Furthermore, the polysaccharides enhance the levels of serum antitumor cytokines, IL 2, IL 6 and IL 7 while decreasing pro-tumor cytokine TNFalpha.	Polysaccharides	17-32	tumor necrosis factor	Mus musculus	138-146
29210428-7	2017	This is one of the few examples of MSNs using biologically relevant glycans for both capping (via interaction with AAL) and targeting (via interaction with overexpressed Lex at the cell membrane).	Polysaccharides	68-75	fucosyltransferase 4	Homo sapiens	170-173
29048873-7	2017	Receptors with signaling capability interact with two distinct sets of mycobacterial glycans: targets for dectin-2 overlap with ligands for the mannose-binding endocytic receptors, while mincle binds exclusively to trehalose-containing structures such as trehalose dimycolate.	Polysaccharides	85-92	C-type lectin domain containing 6A	Homo sapiens	106-114
29423071-0	2018	A spliced form of CD44 expresses the unique glycan that is recognized by the prostate cancer specific antibody F77.	Polysaccharides	44-50	CD44 molecule (Indian blood group)	Homo sapiens	18-22
29143522-2	2017	Herein, we propose a size-shrinkable drug delivery system based on a polysaccharide-modified dendrimer with tumor microenvironment responsiveness for the first time to our knowledge, which was formed by conjugating the terminal glucose of hyaluronic acid (HA) to the superficial amidogen of poly(amidoamine) (PAMAM), using a matrix metalloproteinase-2 (MMP-2)-cleavable peptide (PLGLAG) via click reaction.	Polysaccharides	69-83	matrix metallopeptidase 2	Homo sapiens	325-351
29143522-2	2017	Herein, we propose a size-shrinkable drug delivery system based on a polysaccharide-modified dendrimer with tumor microenvironment responsiveness for the first time to our knowledge, which was formed by conjugating the terminal glucose of hyaluronic acid (HA) to the superficial amidogen of poly(amidoamine) (PAMAM), using a matrix metalloproteinase-2 (MMP-2)-cleavable peptide (PLGLAG) via click reaction.	Polysaccharides	69-83	matrix metallopeptidase 2	Homo sapiens	353-358
29236069-6	2017	The available glycan binding data on the influenza H10 hemagglutinin are discussed in a structure-recognition perspective.	Polysaccharides	14-20	H1.0 linker histone	Homo sapiens	51-54
29039925-2	2017	The plasma membrane-associated sialidase NEU3 is involved in the fine-tuning of sialic acid-containing glycans directly on the cell surface and plays relevant roles in important biological phenomena such as cell differentiation, molecular recognition, and cancer transformation.	Polysaccharides	103-110	neuraminidase 3	Homo sapiens	41-45
29042445-2	2017	The transfer of a glycan from a lipid-linked oligosaccharide (LLO) donor to the asparagine residue of a nascent polypeptide chain is catalyzed by an oligosaccharyltransferase (OST) in the lumen of the endoplasmic reticulum (ER).	Polysaccharides	18-24	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	149-174
29042445-2	2017	The transfer of a glycan from a lipid-linked oligosaccharide (LLO) donor to the asparagine residue of a nascent polypeptide chain is catalyzed by an oligosaccharyltransferase (OST) in the lumen of the endoplasmic reticulum (ER).	Polysaccharides	18-24	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	176-179
29215019-8	2017	We conclude that by promoting the expression of arginine biosynthetic genes, especially argB gene, the ciaR mutation reduced polysaccharide production, resulting in the formation of a fragile biofilm in Streptococcus sanguinis.	Polysaccharides	125-139	acetylglutamate kinase	Streptococcus sanguinis SK36	88-92
29215019-8	2017	We conclude that by promoting the expression of arginine biosynthetic genes, especially argB gene, the ciaR mutation reduced polysaccharide production, resulting in the formation of a fragile biofilm in Streptococcus sanguinis.	Polysaccharides	125-139	response regulator transcription factor	Streptococcus sanguinis SK36	103-107
29039925-7	2017	On the basis of these results, it is plausible that NEU3 activity on exosome glycans enhances the dynamic biological behavior of these small extracellular vesicles by modifying the negative charge and steric hindrance of their glycocalyx.	Polysaccharides	77-84	neuraminidase 3	Homo sapiens	52-56
29225515-1	2017	Background: We have reported that Chinese herbs Astragalus polysaccharide (APS) can inhibit nuclear factor kappaB (NF-kappaB) activity during the development of diabetic nephropathy in mice.	Polysaccharides	59-73	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-124
29333477-6	2017	Glycosylation of Notch receptor extracellular domain by O-fucose and O-GlcNAc glycans is well established as critical regulators for Notch signaling strength (Stanley and Okajima, 2010; Haltom and Jafar-Nejad, 2015; Sawaguchi et al., 2017).	Polysaccharides	78-85	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	69-77
29333477-6	2017	Glycosylation of Notch receptor extracellular domain by O-fucose and O-GlcNAc glycans is well established as critical regulators for Notch signaling strength (Stanley and Okajima, 2010; Haltom and Jafar-Nejad, 2015; Sawaguchi et al., 2017).	Polysaccharides	78-85	notch receptor 1	Homo sapiens	17-22
29177276-4	2017	We also demonstrated that the printed glycans can be further enzymatically modified while appended to the microarray surface by Arabidopsis thaliana xyloglucan xylosyltransferase 2 (AtXXT2).	Polysaccharides	38-45	UDP-xylosyltransferase 2	Arabidopsis thaliana	182-188
29090617-0	2017	Preparation and biological activities of anti-HER2 monoclonal antibodies with fully core-fucosylated homogeneous bi-antennary complex-type glycans.	Polysaccharides	139-146	erb-b2 receptor tyrosine kinase 2	Homo sapiens	46-50
29198923-4	2017	The aim of this study is to investigate the effects of EP and Polysaccharides from Enteromorpha (PEP) on loperamide induced constipated mice model and illustrating mechanism of action.	Polysaccharides	62-77	prolyl endopeptidase	Mus musculus	97-100
28162032-3	2017	Meanwhile, the contents of polysaccharides and proteins (PN) of SMP increased from 31.0 +- 0.32 and 0.8 +- 0.12 mg L-1 to 39.0 +- 0.56 and 61.70 +- 0.78 mg L-1, respectively.	Polysaccharides	27-42	immunoglobulin kappa variable 1-16	Homo sapiens	115-118
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	180-186	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	34-40	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	28-33
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	34-40	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	34-40	CD4 molecule	Homo sapiens	59-62
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	34-40	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	34-40	CD4 molecule	Homo sapiens	154-157
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	34-40	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	34-40	CD4 molecule	Homo sapiens	154-157
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	34-40	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	34-40	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	34-40	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	34-40	CD4 molecule	Homo sapiens	154-157
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	34-40	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	28-33
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	CD4 molecule	Homo sapiens	59-62
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	CD4 molecule	Homo sapiens	154-157
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	CD4 molecule	Homo sapiens	154-157
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	CD4 molecule	Homo sapiens	154-157
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	28-33
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	CD4 molecule	Homo sapiens	59-62
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	CD4 molecule	Homo sapiens	154-157
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	CD4 molecule	Homo sapiens	154-157
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	CD4 molecule	Homo sapiens	154-157
28632942-4	2017	Our results reveal that 276 gp120 glycan can enhance gp120-CD4 and gp120-antibody interactions through the formation of hydrogen bonds of the glycan with CD4 and antibody and make the binding interface of gp120, CD4 and antibody stable; 234 gp120 glycan primarily reinforces gp120-antibody interactions and weakly affects gp120-CD4 interactions as it mainly lies between gp120 and antibody.	Polysaccharides	142-148	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-5	2017	The co-operating of two glycans can enhance gp120-CD4 and gp120-antibody associations.	Polysaccharides	24-31	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	44-49
28632942-5	2017	The co-operating of two glycans can enhance gp120-CD4 and gp120-antibody associations.	Polysaccharides	24-31	CD4 molecule	Homo sapiens	50-53
28632942-5	2017	The co-operating of two glycans can enhance gp120-CD4 and gp120-antibody associations.	Polysaccharides	24-31	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	58-63
28632942-6	2017	Through the structural analysis, it can be seen that 234 gp120 glycan leads to moving upward of two glycans and the variable region of heavy chain, which is favorable for the interactions of gp120 with CD4 and antibody.	Polysaccharides	63-69	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	57-62
28632942-6	2017	Through the structural analysis, it can be seen that 234 gp120 glycan leads to moving upward of two glycans and the variable region of heavy chain, which is favorable for the interactions of gp120 with CD4 and antibody.	Polysaccharides	63-69	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	191-196
28632942-6	2017	Through the structural analysis, it can be seen that 234 gp120 glycan leads to moving upward of two glycans and the variable region of heavy chain, which is favorable for the interactions of gp120 with CD4 and antibody.	Polysaccharides	63-69	CD4 molecule	Homo sapiens	202-205
28632942-6	2017	Through the structural analysis, it can be seen that 234 gp120 glycan leads to moving upward of two glycans and the variable region of heavy chain, which is favorable for the interactions of gp120 with CD4 and antibody.	Polysaccharides	100-107	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	57-62
28632942-6	2017	Through the structural analysis, it can be seen that 234 gp120 glycan leads to moving upward of two glycans and the variable region of heavy chain, which is favorable for the interactions of gp120 with CD4 and antibody.	Polysaccharides	100-107	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	191-196
28632942-6	2017	Through the structural analysis, it can be seen that 234 gp120 glycan leads to moving upward of two glycans and the variable region of heavy chain, which is favorable for the interactions of gp120 with CD4 and antibody.	Polysaccharides	100-107	CD4 molecule	Homo sapiens	202-205
28632942-0	2017	The glycan-mediated mechanism on the interactions of gp120 with CD4 and antibody: Insights from molecular dynamics simulation.	Polysaccharides	4-10	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
28632942-0	2017	The glycan-mediated mechanism on the interactions of gp120 with CD4 and antibody: Insights from molecular dynamics simulation.	Polysaccharides	4-10	CD4 molecule	Homo sapiens	64-67
28632942-1	2017	N-linked glycans such as 234 and 276 gp120 glycans are vital components of HIV evasion from humoral immunity and important for HIV-1 neutralization of many broadly neutralizing antibodies (bNAbs).	Polysaccharides	9-16	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	37-42
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	32-39	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	63-68
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	32-39	CD4 molecule	Homo sapiens	74-77
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	32-39	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	32-39	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	32-39	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	32-39	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	180-187	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	180-187	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	180-187	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	180-187	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	32-38	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	63-68
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	32-38	CD4 molecule	Homo sapiens	74-77
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	180-186	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	180-186	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	180-186	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	180-186	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	180-186	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	180-186	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
28632942-3	2017	To investigate the roles of the glycans on the interactions of gp120 with CD4 and antibody, molecular dynamic simulations based on gp120-CD4-8ANC195 complex with 234 and 276 gp120 glycans, 234 gp120 glycan, 276 gp120 glycan, and without glycan were performed.	Polysaccharides	180-186	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
29195935-3	2017	After digestion, contents of polyphenol, polysaccharide and their antioxidant activity, the inhibitory activity of alpha-amylase and alpha-glucosidase significantly increased.	Polysaccharides	41-55	sucrase-isomaltase	Homo sapiens	133-150
29195935-6	2017	Lycopersicon esculentum Mill and Pyrus bretschneideri Rehd exhibited maximum increase in the inhibitory activity of alpha-glucosidase with lowest contents of polyphenols and polysaccharides.	Polysaccharides	174-189	alpha-glucosidase	Pyrus x bretschneideri	116-133
27314244-4	2017	Previously, we performed a comprehensive glycan profiling of adipose-derived hMSCs using high-density lectin microarray and demonstrated that alpha2-6-sialylation is a marker of the differentiation potential of these cells.	Polysaccharides	41-47	immunoglobulin binding protein 1	Homo sapiens	142-150
27314244-5	2017	Nevertheless, no information was available about the structural details of these of alpha2-6-sialylated glycans.	Polysaccharides	104-111	immunoglobulin binding protein 1	Homo sapiens	84-92
29029079-4	2017	Here we analyzed glycan structures on native EC-SOD purified from human sera, and identified sialylated biantennary structures.	Polysaccharides	17-23	superoxide dismutase 3	Homo sapiens	45-51
29029079-5	2017	Using glycan maturation-defective CHO mutant cells, we further revealed that the presence of terminal sialic acids in the N-glycans of EC-SOD enhanced both the secretion and furin-mediated C-terminal cleavage of EC-SOD.	Polysaccharides	6-12	superoxide dismutase 3	Homo sapiens	135-141
29066631-0	2017	Advancing a High Throughput Glycotope-centric Glycomics Workflow Based on nanoLC-MS2-product Dependent-MS3 Analysis of Permethylated Glycans.	Polysaccharides	133-140	minisatellites detected by probe MMS2	Mus musculus	81-84
29029079-5	2017	Using glycan maturation-defective CHO mutant cells, we further revealed that the presence of terminal sialic acids in the N-glycans of EC-SOD enhanced both the secretion and furin-mediated C-terminal cleavage of EC-SOD.	Polysaccharides	6-12	furin	Cricetulus griseus	174-179
29158348-2	2017	Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolving activities by targeting multiple immune cell types.	Polysaccharides	69-75	galectin 1	Homo sapiens	0-10
29158348-2	2017	Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, displays broad anti-inflammatory and proresolving activities by targeting multiple immune cell types.	Polysaccharides	69-75	galectin 1	Homo sapiens	12-17
29031045-9	2017	Additionally, protein-glycan contacts observed in the crystal structure appear to correlate with IgG3 affinity for Fcgamma receptors as shown by binding studies with IgG3 Fc glycoforms.	Polysaccharides	22-28	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	97-101
29031045-9	2017	Additionally, protein-glycan contacts observed in the crystal structure appear to correlate with IgG3 affinity for Fcgamma receptors as shown by binding studies with IgG3 Fc glycoforms.	Polysaccharides	22-28	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	166-170
27549315-12	2017	Finally, unique GSL signatures in ES and cancer cells are exploited in glycan-targeted anti-cancer immunotherapy and their mechanistic investigations were discussed using anti-GD2 mAb and Globo H as examples.	Polysaccharides	71-77	cathepsin A	Homo sapiens	16-19
28729219-4	2017	Results showed that the hHEP were significantly stronger than that of the corresponding unmodified polysaccharide, HEP.	Polysaccharides	99-113	EPH receptor B6	Homo sapiens	24-28
28729219-4	2017	Results showed that the hHEP were significantly stronger than that of the corresponding unmodified polysaccharide, HEP.	Polysaccharides	99-113	EPH receptor B6	Homo sapiens	25-28
29066631-0	2017	Advancing a High Throughput Glycotope-centric Glycomics Workflow Based on nanoLC-MS2-product Dependent-MS3 Analysis of Permethylated Glycans.	Polysaccharides	133-140	minisatellites detected by probe MMS3	Mus musculus	103-106
29066631-4	2017	We have been pursuing this line of analytical strategy that homes in on identifying the terminal sulfo-, sialyl, and/or fucosylated glycotopes by comprehensive nanoLC-MS2-product dependent MS3 analysis of permethylated glycans, in conjunction with development of a data mining computational tool, GlyPick, to enable an automated, high throughput, semi-quantitative glycotope-centric glycomic mapping amenable to even nonexperts.	Polysaccharides	219-226	minisatellites detected by probe MMS2	Mus musculus	167-170
29066631-4	2017	We have been pursuing this line of analytical strategy that homes in on identifying the terminal sulfo-, sialyl, and/or fucosylated glycotopes by comprehensive nanoLC-MS2-product dependent MS3 analysis of permethylated glycans, in conjunction with development of a data mining computational tool, GlyPick, to enable an automated, high throughput, semi-quantitative glycotope-centric glycomic mapping amenable to even nonexperts.	Polysaccharides	219-226	minisatellites detected by probe MMS3	Mus musculus	189-192
29169316-8	2017	Functional assays showed that glycan binding preference is similar between Siglec-11 and Siglec-16 in all analyzed hominid species.	Polysaccharides	30-36	sialic acid binding Ig like lectin 11	Homo sapiens	75-84
28941182-1	2017	Alginate is a natural rich anionic polysaccharide (APS), commonly available as calcium alginate (CAPS).	Polysaccharides	35-49	calcium dependent secretion activator	Rattus norvegicus	97-101
28956227-5	2017	To understand the mechanism of the ecto-NTPDase activity and substrate specificity, potentially impacted by N-glycans, we have generated soluble enzymatic domains of NTPDase3/CD39L3 in human embryotic kidney cells with four different glycan modifications.	Polysaccharides	110-116	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	166-174
28956227-5	2017	To understand the mechanism of the ecto-NTPDase activity and substrate specificity, potentially impacted by N-glycans, we have generated soluble enzymatic domains of NTPDase3/CD39L3 in human embryotic kidney cells with four different glycan modifications.	Polysaccharides	110-116	ectonucleoside triphosphate diphosphohydrolase 3	Homo sapiens	175-181
29190644-4	2017	From our investigation, we found that the glycan attached to ASN241 is both structurally and functionally important due to its close proximity to the BChE tetramerization domain and the active site gorge.	Polysaccharides	42-48	butyrylcholinesterase	Homo sapiens	150-154
29190644-6	2017	Our simulations indicate that the structure and function of human BChE are significantly affected by the absence of glycan 241.	Polysaccharides	116-122	butyrylcholinesterase	Homo sapiens	66-70
29169316-8	2017	Functional assays showed that glycan binding preference is similar between Siglec-11 and Siglec-16 in all analyzed hominid species.	Polysaccharides	30-36	sialic acid binding Ig like lectin 16	Homo sapiens	89-98
28928219-4	2017	Previous studies have shown that the glycan promotes organization of the F-box-binding region in Skp1 and aids in Skp1"s association with F-box proteins.	Polysaccharides	37-43	S-phase kinase associated protein 1	Homo sapiens	97-101
29107940-9	2017	The lectin-like domain of calreticulin senses the MHC-I glycan, whereas the P domain reaches over the MHC-I peptide-binding pocket towards ERp57.	Polysaccharides	56-62	calreticulin	Homo sapiens	26-38
29068676-0	2017	Cell-Surface Receptor-Ligand Interaction Analysis with Homogeneous Time-Resolved FRET and Metabolic Glycan Engineering: Application to Transmembrane and GPI-Anchored Receptors.	Polysaccharides	100-106	CD177 molecule	Homo sapiens	0-21
28928219-6	2017	Molecular dynamics trajectories of glycosylated Skp1 whose calculated monosaccharide relaxation kinetics and rotational correlation times agreed with the NMR data indicated that the glycan interacts with the loop connecting two alpha-helices of the F-box-combining site.	Polysaccharides	182-188	S-phase kinase associated protein 1	Homo sapiens	48-52
30023556-9	2017	These anti-MUC1 antibodies should thus become powerful tools for biological studies on MUC1 O-glycan structures.	Polysaccharides	94-100	mucin 1, cell surface associated	Homo sapiens	11-15
30023556-9	2017	These anti-MUC1 antibodies should thus become powerful tools for biological studies on MUC1 O-glycan structures.	Polysaccharides	94-100	mucin 1, cell surface associated	Homo sapiens	87-91
28928219-5	2017	Here, NMR and MS approaches were used to determine the glycan structure, and then a combination of NMR and molecular dynamics simulations were employed to characterize the impact of the glycan on the conformation and motions of the intrinsically flexible F-box-binding domain of Skp1.	Polysaccharides	186-192	S-phase kinase associated protein 1	Homo sapiens	279-283
28928219-4	2017	Previous studies have shown that the glycan promotes organization of the F-box-binding region in Skp1 and aids in Skp1"s association with F-box proteins.	Polysaccharides	37-43	S-phase kinase associated protein 1	Homo sapiens	114-118
29296883-9	2017	Last, Env-specific Fc-domain glycan structures and a series of antibody effector functions were assessed by systems serology.	Polysaccharides	29-35	endogenous retrovirus group K member 6, envelope	Homo sapiens	6-9
29150603-1	2017	Oligomannose-type glycans are among the major targets on the gp120 component of the HIV envelope protein (Env) for broadly neutralizing antibodies (bnAbs).	Polysaccharides	18-25	endogenous retrovirus group K member 6, envelope	Homo sapiens	88-104
29150603-1	2017	Oligomannose-type glycans are among the major targets on the gp120 component of the HIV envelope protein (Env) for broadly neutralizing antibodies (bnAbs).	Polysaccharides	18-25	endogenous retrovirus group K member 6, envelope	Homo sapiens	106-109
28927592-0	2017	Preliminary structural characterization and hypoglycemic effects of an acidic polysaccharide SERP1 from the residue of Sarcandra glabra.	Polysaccharides	78-92	stress-associated endoplasmic reticulum protein 1	Mus musculus	93-98
28927622-4	2017	The walls of induced VND7-VP16-GR BY-2 cells consisted of cellulose, pectic polysaccharides, hemicelluloses, and lignin, and contained more xylan and cellulose compared with non-transformed BY-2 and uninduced VND7-VP16-GR BY-2 cells.	Polysaccharides	76-91	NAC domain-containing protein 30-like	Nicotiana tabacum	21-25
28927592-1	2017	An acidic polysaccharide (SERP1) was isolated from the residue of Sarcandra glabra (Thunb.)	Polysaccharides	10-24	stress-associated endoplasmic reticulum protein 1	Mus musculus	26-31
28976746-0	2017	Tailored Multivalent Neo-Glycoproteins: Synthesis, Evaluation, and Application of a Library of Galectin-3-Binding Glycan Ligands.	Polysaccharides	114-120	galectin 3	Homo sapiens	95-105
29019687-4	2017	In this work, we use molecular dynamics trajectories, in aggregate 86.5 mus long, of the glycosylated LBD of the GluN1 subunit of the NMDAR to investigate the behavior of glycans on NMDARs.	Polysaccharides	171-178	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	113-118
28976746-6	2017	Solid-phase binding assays with immobilized neo-glycoproteins revealed distinct affinity and specificity of the multivalent glycan epitopes for Gal-3 binding.	Polysaccharides	124-130	galectin 3	Homo sapiens	144-149
28976746-8	2017	Furthermore, neo-glycoproteins with terminal biotinylated LacNAc glycan motif could be utilized as Gal-3 detection agents in a sandwich enzyme-linked immunosorbent assay format.	Polysaccharides	65-71	galectin 3	Homo sapiens	99-104
29019687-7	2017	We predict that time scales of conformational changes in glycans on the GluN1 LBD of NMDARs range from nanoseconds to at least hundreds of microseconds.	Polysaccharides	57-64	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	72-77
29019687-8	2017	Some of the conformational changes in the glycans correlate with the physiologically important clamshell-like opening and closing of the GluN1 LBD domain.	Polysaccharides	42-49	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	137-142
28986508-0	2017	Macromolecular assemblies of complex polysaccharides with galectin-3 and their synergistic effects on function.	Polysaccharides	37-52	galectin 3	Homo sapiens	58-68
28647147-0	2017	Capillary electrophoresis with stationary nanogel zones of galactosidase and Erythrina cristagalli lectin for the determination of beta(1-3)-linked galactose in glycans.	Polysaccharides	161-168	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	131-139
28986508-4	2017	BioLayer Interferometry and fluorescence-linked immunosorbent assays indicate that these polysaccharides bind Gal-3 with macroscopic or apparent KD values of 49 nM, 46 microM, and 138 microM, respectively.	Polysaccharides	89-104	galectin 3	Homo sapiens	110-115
28986508-5	2017	15N-1H heteronuclear single quantum coherence (HSQC) NMR studies reveal that these polysaccharides interact primarily with the F-face of the Gal-3 carbohydrate recognition domain.	Polysaccharides	83-98	galectin 3	Homo sapiens	141-146
28986508-9	2017	Overall, the present study contributes to our understanding of how complex HG and RG polysaccharides interact with Gal-3.	Polysaccharides	85-100	galectin 3	Homo sapiens	115-120
29416702-6	2018	Thus, some of these glycan changes like carbohydrate antigen CA 19-9 (sialyl Lewis a, sLea) or those found on carcinoembryonic antigen (CEA) are already used as clinical biomarkers to detect and monitor CRC.	Polysaccharides	20-26	CEA cell adhesion molecule 3	Homo sapiens	136-139
29045792-1	2017	The macrophage galactose-type lectin (MGL) recognizes glycan moieties exposed by pathogens and malignant cells.	Polysaccharides	54-60	C-type lectin domain family 10, member A	Mus musculus	4-36
29045792-1	2017	The macrophage galactose-type lectin (MGL) recognizes glycan moieties exposed by pathogens and malignant cells.	Polysaccharides	54-60	C-type lectin domain family 10, member A	Mus musculus	38-41
29045792-3	2017	To estimate the ability of distinct MGL orthologs to recognize aberrant glycan cores in mucins, we applied evanescent-field detection to a versatile MUC1-like glycopeptide microarray platform.	Polysaccharides	72-78	C-type lectin domain family 10, member A	Mus musculus	36-39
29045792-5	2017	In addition, we observed for all three MGL orthologs that divalent glycan presentation increased the binding.	Polysaccharides	67-73	C-type lectin domain family 10, member A	Mus musculus	39-42
29416702-6	2018	Thus, some of these glycan changes like carbohydrate antigen CA 19-9 (sialyl Lewis a, sLea) or those found on carcinoembryonic antigen (CEA) are already used as clinical biomarkers to detect and monitor CRC.	Polysaccharides	20-26	CEA cell adhesion molecule 3	Homo sapiens	110-134
28988747-4	2017	Among these antibodies, O13 exhibits superior specificity for H-trisaccharide, the basis for which is revealed by comparative analysis of high-resolution VLR:glycan crystal structures.	Polysaccharides	158-164	immunoglobulin kappa variable 2-38 (pseudogene)	Homo sapiens	24-27
29100095-4	2017	GPAA1 (glycosylphosphatidylinositol anchor attachment 1) is an essential component of the transamidase complex along with PIGK, PIGS, PIGT, and PIGU (phosphatidylinositol-glycan biosynthesis classes K, S, T, and U, respectively).	Polysaccharides	171-177	glycosylphosphatidylinositol anchor attachment 1	Sus scrofa	0-5
29100095-4	2017	GPAA1 (glycosylphosphatidylinositol anchor attachment 1) is an essential component of the transamidase complex along with PIGK, PIGS, PIGT, and PIGU (phosphatidylinositol-glycan biosynthesis classes K, S, T, and U, respectively).	Polysaccharides	171-177	glycosylphosphatidylinositol anchor attachment 1	Sus scrofa	7-55
28906131-13	2017	An important new group of promising sole Th2 adjuvants are the fucosylated glycans, which by binding to DC-SIGN bias dendritic cells to Th2 immunity while inhibiting Th1/Th7 immunities.	Polysaccharides	75-82	negative elongation factor complex member C/D	Homo sapiens	166-169
29096607-2	2017	Biallelic variants in PIGN, encoding phosphatidylinositol-glycan biosynthesis class N have been recently associated with multiple congenital anomalies hypotonia seizure syndrome.	Polysaccharides	58-64	phosphatidylinositol glycan anchor biosynthesis class N	Homo sapiens	22-26
29040651-2	2017	Mutation of MEX1 causes a slow-down in the mobilization of storage polysaccharide.	Polysaccharides	67-81	uncharacterized protein	Chlamydomonas reinhardtii	12-16
28973299-0	2017	Novel polysaccharide binding to the N-terminal tail of galectin-3 is likely modulated by proline isomerization.	Polysaccharides	6-20	galectin 3	Homo sapiens	55-65
28958189-6	2017	The results indicate that Gal-9 and possibly other galectins recognize glycans attached to small leucine-rich repeat proteoglycans associated with insoluble elastin and also indicate the possibility that mature insoluble elastin serves as an extracellular reservoir for galectins.	Polysaccharides	71-78	galectin 9	Homo sapiens	26-31
28776443-0	2017	Exploring the immunopotentiation of Chinese yam polysaccharide poly(lactic-co-glycolic acid) nanoparticles in an ovalbumin vaccine formulation in vivo.	Polysaccharides	48-62	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	113-122
28747404-3	2017	Gal-8 interacts with newly synthesized Gp135 in a glycan-dependent manner.	Polysaccharides	50-56	podocalyxin like	Canis lupus familiaris	39-44
28973299-2	2017	The present study is focused on human galectin-3 (Gal-3) interactions with a 60 kDa rhamnogalacturonan RG-I-4 that we use as a model to garner information as to how galectins interact with large polysaccharides, as well as to develop this agent as a therapeutic against human disease.	Polysaccharides	195-210	galectin 3	Homo sapiens	38-48
28973299-2	2017	The present study is focused on human galectin-3 (Gal-3) interactions with a 60 kDa rhamnogalacturonan RG-I-4 that we use as a model to garner information as to how galectins interact with large polysaccharides, as well as to develop this agent as a therapeutic against human disease.	Polysaccharides	195-210	galectin 3	Homo sapiens	50-55
28830011-0	2017	Inhibition of EGF-induced migration and invasion by sulfated polysaccharide of Sepiella maindroni ink via the suppression of EGFR/Akt/p38 MAPK/MMP-2 signaling pathway in KB cells.	Polysaccharides	61-75	epidermal growth factor	Homo sapiens	14-17
28617415-9	2017	Antithrombin-III levels and transferrin-glycosylation showed significant improvement, and increase in galactosylation and whole glycan content.	Polysaccharides	128-134	serpin family C member 1	Homo sapiens	0-16
28634059-0	2017	A pumpkin polysaccharide induces apoptosis by inhibiting the JAK2/STAT3 pathway in human hepatoma HepG2 cells.	Polysaccharides	10-24	Janus kinase 2	Homo sapiens	61-65
28666830-4	2017	The production of TNF-alpha, IL-1beta and IL-6 and their mRNA expression levels markedly decreased while the level and mRNA expression of IL-10 were elevated when the cells were treated with Sophora subprosrate polysaccharide.	Polysaccharides	211-225	tumor necrosis factor	Homo sapiens	18-27
28666830-4	2017	The production of TNF-alpha, IL-1beta and IL-6 and their mRNA expression levels markedly decreased while the level and mRNA expression of IL-10 were elevated when the cells were treated with Sophora subprosrate polysaccharide.	Polysaccharides	211-225	interleukin 1 beta	Homo sapiens	29-37
28666830-4	2017	The production of TNF-alpha, IL-1beta and IL-6 and their mRNA expression levels markedly decreased while the level and mRNA expression of IL-10 were elevated when the cells were treated with Sophora subprosrate polysaccharide.	Polysaccharides	211-225	interleukin 6	Homo sapiens	42-46
28636877-5	2017	Analysis of most common glycan motifs for CGL showed high affinity to Galalpha1-4Galbeta1-4GlcNAc motif similar to globotriose structure (Gb3: Galalpha1-4Galbeta1-4Glc), the epitope of globotriaosylceramide.	Polysaccharides	24-30	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	138-141
28634059-0	2017	A pumpkin polysaccharide induces apoptosis by inhibiting the JAK2/STAT3 pathway in human hepatoma HepG2 cells.	Polysaccharides	10-24	signal transducer and activator of transcription 3	Homo sapiens	66-71
28666830-4	2017	The production of TNF-alpha, IL-1beta and IL-6 and their mRNA expression levels markedly decreased while the level and mRNA expression of IL-10 were elevated when the cells were treated with Sophora subprosrate polysaccharide.	Polysaccharides	211-225	interleukin 10	Homo sapiens	138-143
28887379-13	2017	The results show that the simultaneous consideration of peptide and glycan fragmentation is necessary for high quality MSn spectrum annotation in CID and HCD fragmentation modes.	Polysaccharides	68-74	moesin	Homo sapiens	119-122
28992081-4	2017	Wnt1 was modified with a complex- or hybrid-type glycan at Asn29 and Asn359 and the high-mannose- or hybrid-type glycan at Asn316.	Polysaccharides	49-55	Wnt family member 1	Canis lupus familiaris	0-4
28992081-4	2017	Wnt1 was modified with a complex- or hybrid-type glycan at Asn29 and Asn359 and the high-mannose- or hybrid-type glycan at Asn316.	Polysaccharides	113-119	Wnt family member 1	Canis lupus familiaris	0-4
28853212-5	2017	The MS profiling by PGC-LC also revealed several glycan structural isomers that corresponded to LacdiNAc-type (GalNAcbeta1-4GlcNAc) motifs that were unique to the serous ovarian cancers and that correlated with elevated gene expression of B4GALNT3 and B4GALNT4 in patients with serous cancer.	Polysaccharides	49-55	beta-1,4-N-acetyl-galactosaminyltransferase 3	Homo sapiens	239-247
28853212-5	2017	The MS profiling by PGC-LC also revealed several glycan structural isomers that corresponded to LacdiNAc-type (GalNAcbeta1-4GlcNAc) motifs that were unique to the serous ovarian cancers and that correlated with elevated gene expression of B4GALNT3 and B4GALNT4 in patients with serous cancer.	Polysaccharides	49-55	beta-1,4-N-acetyl-galactosaminyltransferase 4	Homo sapiens	252-260
29104211-2	2017	The chemical structure and anti-tumor activities of purified oyster polysaccharides (OP-1) were also investigated.	Polysaccharides	68-83	bone morphogenetic protein 7	Homo sapiens	85-89
28878084-8	2017	This report identifies interactions of vIL-6 and VKORC1v2 with calnexin cycle enzymes GlucII and UGGT1, which are involved in glycan processing and nascent protein folding.	Polysaccharides	126-132	K2	Human gammaherpesvirus 8	39-44
29143776-3	2017	We aimed at disclosing relevant ErbB2 glycan signatures and their functional impact on receptor"s biology in GC cells.	Polysaccharides	38-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	32-37
29143776-5	2017	Cellular- and receptor-specific glycan profiling of ErbB2-overexpressing NCI-N87 cells unveiled a heterogeneous glycosylation pattern harboring the tumor-associated sialyl Lewis a (SLea) antigen.	Polysaccharides	32-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	52-57
29143776-9	2017	Altogether, NCI-N87 cell line constitutes an appealing in vitro model to address glycan-mediated regulation of ErbB2 in GC.	Polysaccharides	81-87	erb-b2 receptor tyrosine kinase 2	Homo sapiens	111-116
28878084-8	2017	This report identifies interactions of vIL-6 and VKORC1v2 with calnexin cycle enzymes GlucII and UGGT1, which are involved in glycan processing and nascent protein folding.	Polysaccharides	126-132	calnexin	Homo sapiens	63-71
28878084-8	2017	This report identifies interactions of vIL-6 and VKORC1v2 with calnexin cycle enzymes GlucII and UGGT1, which are involved in glycan processing and nascent protein folding.	Polysaccharides	126-132	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	97-102
29155734-0	2017	Structural Characterization of Mannan Cell Wall Polysaccharides in Plants Using PACE.	Polysaccharides	48-63	furin, paired basic amino acid cleaving enzyme	Homo sapiens	80-84
29187897-0	2017	Glycan and Peptide IgE Epitopes of the TNF-alpha Blockers Infliximab and Adalimumab - Precision Diagnostics by Cross-Reactivity Immune Profiling of Patient Sera.	Polysaccharides	0-6	tumor necrosis factor	Homo sapiens	39-48
29155734-3	2017	For polysaccharide analysis by gel electrophoresis (PACE), plant cell wall material is hydrolyzed with glycosyl hydrolases specific to the polysaccharide of interest (e.g., mannanases for mannan).	Polysaccharides	4-18	furin, paired basic amino acid cleaving enzyme	Homo sapiens	52-56
29155734-3	2017	For polysaccharide analysis by gel electrophoresis (PACE), plant cell wall material is hydrolyzed with glycosyl hydrolases specific to the polysaccharide of interest (e.g., mannanases for mannan).	Polysaccharides	139-153	furin, paired basic amino acid cleaving enzyme	Homo sapiens	52-56
29038476-0	2017	Pro-angiogenic effect of RANTES-loaded polysaccharide-based microparticles for a mouse ischemia therapy.	Polysaccharides	39-53	chemokine (C-C motif) ligand 5	Mus musculus	25-31
28947103-3	2017	Here, we report our investigation on glycan-mAb interactions by using the unique architectural scaffold of 2G12, an antibody that targets oligomannoses on the HIV-1 glycoprotein gp120, as the template for engineering highly specific mAbs to target glycans.	Polysaccharides	37-43	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	178-183
28821118-1	2017	In this study, a sulfated polysaccharide (S-CP1-8) was obtained from Cyclocarya paliurus by chlorosulfonic acid-pyridine method.	Polysaccharides	26-40	stem cell proliferation 1	Mus musculus	42-49
28947103-7	2017	We analyzed the sequences of 39 variants from Lib1 and 14 variants from Lib2 following selection against gp120, the results showed that there is a high degree of malleability within the 2G12 for glycan recognitions.	Polysaccharides	195-201	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	105-110
29016670-10	2017	Thus, two glycoproteins, AHSG and HPX, represent a pivotal glycoprotein of the cytoprotective activity for WN1316, showing a concrete evidence for the novel glycan-independent function of serum glycoproteins in neuroprotective drug efficacy.	Polysaccharides	157-163	alpha 2-HS glycoprotein	Homo sapiens	25-29
29016670-10	2017	Thus, two glycoproteins, AHSG and HPX, represent a pivotal glycoprotein of the cytoprotective activity for WN1316, showing a concrete evidence for the novel glycan-independent function of serum glycoproteins in neuroprotective drug efficacy.	Polysaccharides	157-163	hemopexin	Homo sapiens	34-37
28711405-0	2017	A unique glycan-isoform of transferrin in cerebrospinal fluid: A potential diagnostic marker for neurological diseases.	Polysaccharides	9-15	transferrin	Homo sapiens	27-38
28986561-7	2017	We demonstrate that galectin-3 binds the glycans of the extracellular matrix and those decorating IFNgamma.	Polysaccharides	41-48	galectin 3	Homo sapiens	20-30
28890362-2	2017	Here we use molecular dynamics to provide insight into its structural dynamics and into how both protomer and glycan movements coordinate to shield the Env protein surface.	Polysaccharides	110-116	endogenous retrovirus group W member 1, envelope	Homo sapiens	152-155
28890362-4	2017	Network analysis showed that highly conserved glycans combined with protomer scissoring to restrict access to the binding site of the CD4 receptor.	Polysaccharides	46-53	CD4 molecule	Homo sapiens	134-146
28890362-7	2017	Overall, our results provide a microsecond-based understanding of the Env glycan shield.	Polysaccharides	74-80	endogenous retrovirus group W member 1, envelope	Homo sapiens	70-73
28988659-6	2017	The histochemical analysis demonstrated an intense reaction for proteins and polysaccharides in peripheral cytoplasm of Oc3 comparing to others cell types.	Polysaccharides	77-92	one cut homeobox 3	Homo sapiens	120-123
28844534-9	2017	This is the first report demonstrating the presence in SSTs of the OC-116, OC-17 and OCX36 eggshell matrix proteins, and their concomitant presence with Gal/GalNAc and Glc/GlcNAc glycans, as well as with calcium.	Polysaccharides	179-186	matrix extracellular phosphoglycoprotein	Gallus gallus	67-80
28899088-7	2017	The specificity of labeling was confirmed by sialidase treatment of target cells and using glycan recognition-deficient mutant CD22 probes.	Polysaccharides	91-97	CD22 molecule	Homo sapiens	127-131
28711405-2	2017	SCOPE OF REVIEW: CSF contains glycan isoforms of transferrin (Tf): one appears to be derived from the brain and the other from blood.	Polysaccharides	30-36	transferrin	Homo sapiens	49-60
28814130-0	2017	Identification and characterization of a sulfoglycosidase from Bifidobacterium bifidum implicated in mucin glycan utilization.	Polysaccharides	107-113	LOC100508689	Homo sapiens	101-106
28243851-0	2017	Inactivation of Kupffer Cells by Selenizing Astragalus Polysaccharides Prevents CCl4-Induced Hepatocellular Necrosis in the Male Wistar Rat.	Polysaccharides	55-70	C-C motif chemokine ligand 4	Rattus norvegicus	80-84
28814130-2	2017	However, our knowledge about mucin type O-glycan degradation by bifidobacteria remains fragmentary, especially regarding how they decompose sulfated glycans, which are abundantly found in mucin sugar-chains.	Polysaccharides	149-156	LOC100508689	Homo sapiens	29-34
28814130-2	2017	However, our knowledge about mucin type O-glycan degradation by bifidobacteria remains fragmentary, especially regarding how they decompose sulfated glycans, which are abundantly found in mucin sugar-chains.	Polysaccharides	149-156	LOC100508689	Homo sapiens	188-193
28814130-6	2017	This de-capping activity may promote utilization of sulfated glycans of mucin by other bacteria including bifidobacteria, thereby establishing the symbiotic relationship between human and gut microbes.	Polysaccharides	61-68	LOC100508689	Homo sapiens	72-77
28743090-1	2017	Hyaluronic acid (HA) is an endogenous polysaccharide that shows intrinsic targetability to CD44+ cancer cells.	Polysaccharides	38-52	CD44 molecule (Indian blood group)	Homo sapiens	91-95
28732858-3	2017	The optimal extraction conditions with a yield of 2.84+-0.09% for extraction of polysaccharides (STP-1) were extraction time 23min, microwave power 547W, extraction temperature 80 C, and the ratio of raw material to water 1:27g/mL.	Polysaccharides	80-95	transition protein 1	Homo sapiens	97-102
28732877-1	2017	The polysaccharide SEP has been reported to activate NK and T cells via TLR2/4.	Polysaccharides	4-18	toll like receptor 2	Homo sapiens	72-78
28994411-2	2017	While these studies have revealed critical mechanisms by which bNAbs recognize and/or accommodate N-glycans on the trimeric envelope glycoprotein (Env), they have been limited to the visualization of high-mannose glycan forms only, since heterogeneity introduced from the presence of complex glycans makes it difficult to obtain high-resolution structures.	Polysaccharides	100-106	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	124-145
28994411-2	2017	While these studies have revealed critical mechanisms by which bNAbs recognize and/or accommodate N-glycans on the trimeric envelope glycoprotein (Env), they have been limited to the visualization of high-mannose glycan forms only, since heterogeneity introduced from the presence of complex glycans makes it difficult to obtain high-resolution structures.	Polysaccharides	100-106	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	147-150
28994411-2	2017	While these studies have revealed critical mechanisms by which bNAbs recognize and/or accommodate N-glycans on the trimeric envelope glycoprotein (Env), they have been limited to the visualization of high-mannose glycan forms only, since heterogeneity introduced from the presence of complex glycans makes it difficult to obtain high-resolution structures.	Polysaccharides	100-107	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	124-145
28994411-2	2017	While these studies have revealed critical mechanisms by which bNAbs recognize and/or accommodate N-glycans on the trimeric envelope glycoprotein (Env), they have been limited to the visualization of high-mannose glycan forms only, since heterogeneity introduced from the presence of complex glycans makes it difficult to obtain high-resolution structures.	Polysaccharides	100-107	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	147-150
28994411-3	2017	3.5 and 3.9 A resolution crystal structures of the HIV-1 Env trimer with fully processed and native glycosylation were solved, revealing a glycan shield of high-mannose and complex-type N-glycans that were used to define the complete epitopes of two bNAbs.	Polysaccharides	139-145	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	57-60
28942945-0	2017	Polysaccharides derived from Ganoderma lucidum fungus mycelia ameliorate indomethacin-induced small intestinal injury via induction of GM-CSF from macrophages.	Polysaccharides	0-15	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	135-141
28816630-3	2017	All protein and polysaccharide samples of the plants led to greater lymphocyte proliferation and TNF-alpha and IL-6 production in cultured splenocytes than did the crude water extracts at the same concentrations tested.	Polysaccharides	16-30	tumor necrosis factor	Mus musculus	97-106
28679530-4	2017	By altering the primary sequence of PDI, we changed the glycan/protein interaction and thus the site-specific glycoprofile because of the improved enzymatic fluxes at enzymatic bottlenecks.	Polysaccharides	56-62	protein disulfide-isomerase	Cricetulus griseus	36-39
28527988-0	2017	Codonopsis lanceolata polysaccharide CLPS inhibits melanoma metastasis via regulating integrin signaling.	Polysaccharides	22-36	colipase, pancreatic	Mus musculus	37-41
28527988-2	2017	Here, we evaluated the molecular mechanisms underlying the anti-metastatic capacity of a polysaccharide fraction (CLPS) from Codonopsis lanceolata.	Polysaccharides	89-103	colipase, pancreatic	Mus musculus	114-118
28527995-3	2017	In the present study, we investigated the inhibitory activity of Aconitum coreanum polysaccharide (ACP1) and its sulphated derivative ACP1-s on migratory behaviour of human breast cancer cells MDA-MB-435s and evaluated the underlying molecular mechanism.	Polysaccharides	83-97	acid phosphatase 1	Homo sapiens	99-103
28528001-1	2017	In this study, a homogeneous polysaccharide (LEP1) with an average molecular weight of 53kDa was successfully purified from the fruiting bodies of Lentinus edodes and its anticancer efficacy on human cervical carcinoma HeLa cells in vitro and associated possible molecular mechanism were also evaluated.	Polysaccharides	29-43	late cornified envelope 1A	Homo sapiens	45-49
28956354-3	2017	Our previous studies confirmed that mucosal immunization with live attenuated strain SPY1 can protect mice against nasopharyngeal colonization of S. pneumoniae and lethal pneumococcal infection, and the protective effects are comparable with those induced by commercially available 23-valent polysaccharide vaccine.	Polysaccharides	292-306	speedy/RINGO cell cycle regulator family, member A	Mus musculus	85-89
28816630-3	2017	All protein and polysaccharide samples of the plants led to greater lymphocyte proliferation and TNF-alpha and IL-6 production in cultured splenocytes than did the crude water extracts at the same concentrations tested.	Polysaccharides	16-30	interleukin 6	Mus musculus	111-115
28546465-9	2017	Extent of PD-L1 glycan modification varied by ~10-fold and the melanoma with the highest PD-L1 protein abundance and most abundant glycan modification yielded a very low PD-L1 IHC estimate, thus suggesting that N-glycosylation may affect IHC measurement and PD-L1 function.	Polysaccharides	16-22	CD274 molecule	Homo sapiens	10-15
28576848-6	2017	The glycan profiles of CHO expressed FcgammaRI and FcgammaRIIIaPhe158/Val158 were compared with the glycan profiles of the receptors expressed in NS0 and HEK293 cells and we show that the glycan type and abundance differs significantly between the receptors and that these glycan differences lead to the observed differences in the respective FcgammaR binding patterns with rituximab.	Polysaccharides	4-10	Fc receptor, IgG, high affinity I	Mus musculus	37-46
28796447-5	2017	PFAA-derivatized mannosamine and galactosamine were successfully transformed into cell-surface glycans and efficiently labeled with phosphine-derivatized fluorophore-conjugated bovine serum albumin.	Polysaccharides	95-102	albumin	Homo sapiens	184-197
28576848-8	2017	On FcgammaRI and FcgammaRIIIa large and sialylated glycans have a negative impact on rituximab binding, likely through destabilization of the interaction.	Polysaccharides	51-58	Fc gamma receptor IIIa	Homo sapiens	17-29
28346799-3	2017	Lipopolysaccharides (LPS), a polysaccharide in the outer membrane of Gram-negative bacteria, elicit strong immune responses, which was often applied to activate macrophages, resulting in a proinflammatory M1 phenotype, and the release of proinflammatory cytokines, including tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1, and IL-6.	Polysaccharides	4-18	tumor necrosis factor	Homo sapiens	275-302
28346799-3	2017	Lipopolysaccharides (LPS), a polysaccharide in the outer membrane of Gram-negative bacteria, elicit strong immune responses, which was often applied to activate macrophages, resulting in a proinflammatory M1 phenotype, and the release of proinflammatory cytokines, including tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1, and IL-6.	Polysaccharides	4-18	tumor necrosis factor	Homo sapiens	304-312
28346799-3	2017	Lipopolysaccharides (LPS), a polysaccharide in the outer membrane of Gram-negative bacteria, elicit strong immune responses, which was often applied to activate macrophages, resulting in a proinflammatory M1 phenotype, and the release of proinflammatory cytokines, including tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1, and IL-6.	Polysaccharides	4-18	interleukin 1 alpha	Homo sapiens	315-333
28346799-3	2017	Lipopolysaccharides (LPS), a polysaccharide in the outer membrane of Gram-negative bacteria, elicit strong immune responses, which was often applied to activate macrophages, resulting in a proinflammatory M1 phenotype, and the release of proinflammatory cytokines, including tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1, and IL-6.	Polysaccharides	4-18	interleukin 6	Homo sapiens	339-343
29845067-0	2017	Anti-Vasculogenic Activity of a Polysaccharide Derived from Brittle Star via Inhibition of VEGF, Paxillin and MMP-9.	Polysaccharides	32-46	vascular endothelial growth factor A	Homo sapiens	91-95
29845067-0	2017	Anti-Vasculogenic Activity of a Polysaccharide Derived from Brittle Star via Inhibition of VEGF, Paxillin and MMP-9.	Polysaccharides	32-46	paxillin	Homo sapiens	97-105
29845067-0	2017	Anti-Vasculogenic Activity of a Polysaccharide Derived from Brittle Star via Inhibition of VEGF, Paxillin and MMP-9.	Polysaccharides	32-46	matrix metallopeptidase 9	Homo sapiens	110-115
29845067-13	2017	The RT-PCR analysis showed that the extracted polysaccharide (40, 60 microg.mL-1) down-regulated the VEGF expression.	Polysaccharides	46-60	vascular endothelial growth factor A	Homo sapiens	101-105
29845067-14	2017	Further, the diminished attachment of endothelial cells demonstrated that the anti-invasiveness of the derived polysaccharide (25, 50 microg.mL-1) was administrated via down-regulation of paxillin and MMP-9 mRNA expression.	Polysaccharides	111-125	paxillin	Homo sapiens	188-196
29845067-14	2017	Further, the diminished attachment of endothelial cells demonstrated that the anti-invasiveness of the derived polysaccharide (25, 50 microg.mL-1) was administrated via down-regulation of paxillin and MMP-9 mRNA expression.	Polysaccharides	111-125	matrix metallopeptidase 9	Homo sapiens	201-206
28422294-5	2017	The antiviral activity of polysaccharides of A. platensis against KHV was confirmed in vitro using qualitative assessment of KHV life cycle genes, and it was found by RT-PCR that EPS, applied at a concentration of &gt;18 mug mL-1 and a multiplicity of infection (MOI) of 0.45 of KHV, suppressed the viral replication in common carp brain (CCB) cells even after 22 days post-infection, entirely.	Polysaccharides	26-41	L1 cell adhesion molecule	Mus musculus	225-229
28969604-4	2017	However, we still lack direct evidences to clarify the biological effect of glycan-specific IgG antibody in IgAN.	Polysaccharides	76-82	IGAN1	Homo sapiens	108-112
28969604-10	2017	CONCLUSIONS: We found that glycan-specific IgG antibodies derived from patients with IgAN had the biological effect to induce mesangial cells proliferation.	Polysaccharides	27-33	IGAN1	Homo sapiens	85-89
28973980-4	2017	Both tested polysaccharides PS-Fuc and PS-FCS have a similar activity to r G-CSF, causing pronounced neutropoiesis stimulation in animals with myelosuppression induced by cyclophosphamide (CPh).	Polysaccharides	12-27	colony stimulating factor 3 (granulocyte)	Mus musculus	75-80
30263731-4	2018	was isolated from cattle feces that produced a mannanase, a polysaccharide-degrading enzyme active against the green seaweed Codium fragile.	Polysaccharides	60-74	mannosidase beta	Bos taurus	47-56
27224877-3	2017	However, in this review we focus on the prebiotics properties in humans of the non-bioaccessible material of nuts (polymerized polyphenols and polysaccharides), which provides substrates for the human gut microbiota and on the formation of new bioactive metabolites and the absorption of that may partly explain the health benefits of nut consumption.	Polysaccharides	143-158	NUT midline carcinoma family member 1	Homo sapiens	109-112
28701401-4	2017	In glycan-binding assays, the H10 viruses preferentially bound "avian-like" alpha2,3-linked sialic acids.	Polysaccharides	3-9	H1.0 linker histone	Homo sapiens	30-33
28829594-3	2017	We describe here a chemically defined natural N-linked glycan scaffold that displays high affinity CD22 glycan ligands and outcompetes the natural ligand for the receptor, resulting in single molecule binding to CD22 and endocytosis into cells.	Polysaccharides	55-61	CD22 molecule	Homo sapiens	99-103
28829594-3	2017	We describe here a chemically defined natural N-linked glycan scaffold that displays high affinity CD22 glycan ligands and outcompetes the natural ligand for the receptor, resulting in single molecule binding to CD22 and endocytosis into cells.	Polysaccharides	55-61	CD22 molecule	Homo sapiens	212-216
28784322-0	2017	Enantioseparation of angiotensin II receptor type 1 blockers: evaluation of 6-substituted carbamoyl benzimidazoles on immobilized polysaccharide-based chiral stationary phases.	Polysaccharides	130-144	angiotensin II receptor type 1	Homo sapiens	21-51
28684300-7	2017	RESULTS: The liquid oral formulation of Poriacocos polysaccharides reduced Bcl-2 protein levels and increased caspase-3 and -9 protein levels in sarcoma 180 cells.	Polysaccharides	51-66	B cell leukemia/lymphoma 2	Mus musculus	75-80
28684300-7	2017	RESULTS: The liquid oral formulation of Poriacocos polysaccharides reduced Bcl-2 protein levels and increased caspase-3 and -9 protein levels in sarcoma 180 cells.	Polysaccharides	51-66	caspase 3	Mus musculus	110-119
28684300-8	2017	CONCLUSION: The mechanism underlying the antitumor effects of the oral liquid formulation of Poriacocos polysaccharides involved inhibition of Bcl-2 expression and activation of caspase-9 expression in sarcoma 180 cells.	Polysaccharides	104-119	B cell leukemia/lymphoma 2	Mus musculus	143-148
28684300-8	2017	CONCLUSION: The mechanism underlying the antitumor effects of the oral liquid formulation of Poriacocos polysaccharides involved inhibition of Bcl-2 expression and activation of caspase-9 expression in sarcoma 180 cells.	Polysaccharides	104-119	caspase 9	Mus musculus	178-187
28880250-0	2017	Glycans as Regulatory Elements of the Insulin/IGF System: Impact in Cancer Progression.	Polysaccharides	0-7	insulin	Homo sapiens	38-45
28887481-4	2017	Herein, we report that Gal-1 and its bound glycans were highly expressed in fibrotic livers and activated HSCs.	Polysaccharides	43-50	lectin, galactose binding, soluble 1	Mus musculus	23-28
28729420-6	2017	However, Man5GlcNAc2 glycan could be efficiently core-fucosylated by FUT8 in an appropriate protein/peptide context, such as with the erythropoietin protein, a V3 polypeptide derived from HIV-1 gp120, or a simple 9-fluorenylmethyl chloroformate-protected Asn moiety.	Polysaccharides	21-27	fucosyltransferase 8	Homo sapiens	69-73
28729420-6	2017	However, Man5GlcNAc2 glycan could be efficiently core-fucosylated by FUT8 in an appropriate protein/peptide context, such as with the erythropoietin protein, a V3 polypeptide derived from HIV-1 gp120, or a simple 9-fluorenylmethyl chloroformate-protected Asn moiety.	Polysaccharides	21-27	erythropoietin	Homo sapiens	134-148
28729420-6	2017	However, Man5GlcNAc2 glycan could be efficiently core-fucosylated by FUT8 in an appropriate protein/peptide context, such as with the erythropoietin protein, a V3 polypeptide derived from HIV-1 gp120, or a simple 9-fluorenylmethyl chloroformate-protected Asn moiety.	Polysaccharides	21-27	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	194-199
28774562-6	2017	Taken together, these findings show that IgA deficiency impairs IgG class switching following vaccination with polysaccharide antigens and that live bacterial immunization can overcome this defect.	Polysaccharides	111-125	immunoglobulin heavy constant alpha	Mus musculus	41-44
28878367-1	2017	Polymorphisms of the FUT2 gene alters glycan ABO(H) blood group and Lewis antigen expression (commonly known as non-secretor status) in the small intestinal mucosa.	Polysaccharides	38-44	fucosyltransferase 2	Homo sapiens	21-25
28878367-1	2017	Polymorphisms of the FUT2 gene alters glycan ABO(H) blood group and Lewis antigen expression (commonly known as non-secretor status) in the small intestinal mucosa.	Polysaccharides	38-44	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	45-48
28932688-13	2017	This was confirmed by glycan profiling, which identified ahomozygous mutation in ALG9, c.860A &gt; G (p.Tyr287Cys) (NM_1234567890).	Polysaccharides	22-28	ALG9 alpha-1,2-mannosyltransferase	Homo sapiens	81-85
28622163-2	2017	RECENT FINDINGS: Mucin 1 is a transmembrane mucin with a robust glycan-dependent apical targeting signal and efficient recycling from endosomes.	Polysaccharides	64-70	mucin 1, transmembrane	Mus musculus	17-24
28140757-1	2017	In this study, a Ganoderma lucidum polysaccharide GLP-1-1 was isolated from a culture broth with Mw of 22014 Da.	Polysaccharides	35-49	glucagon like peptide 1 receptor	Homo sapiens	50-57
28738269-3	2017	The primary goal of the present research was to assess whether PSs attenuate inflammatory processes by interfering with tumour necrosis factor-alpha (TNF-alpha)-induced inflammation, in human coronary artery endothelial cells (HCAECs).	Polysaccharides	63-66	tumor necrosis factor	Homo sapiens	150-159
28738269-7	2017	RESULTS: The TNF-alpha-induced up-regulation of inter-cellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) translocation, as well as IkappaB degradation were significantly attenuated in cells pre-treated with PSs.	Polysaccharides	317-320	tumor necrosis factor	Homo sapiens	13-22
28738269-7	2017	RESULTS: The TNF-alpha-induced up-regulation of inter-cellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) translocation, as well as IkappaB degradation were significantly attenuated in cells pre-treated with PSs.	Polysaccharides	317-320	vascular cell adhesion molecule 1	Homo sapiens	131-137
28738269-8	2017	In addition, PSs were able to inhibit NF-kappaB activation as well as TNF-alpha-induced oxidative stress in HCAECs.	Polysaccharides	13-16	tumor necrosis factor	Homo sapiens	70-79
28738269-10	2017	CONCLUSIONS: This is the first report that demonstrates the anti-inflammatory effect and vaso-relaxing property of red microalgae PSs in a HCAEC-TNF-alpha induced system.	Polysaccharides	130-133	tumor necrosis factor	Homo sapiens	145-154
28774562-1	2017	We report that IgA-/- mice exhibit specific defects in IgG antibody responses to various polysaccharide vaccines (Francisella tularensis LPS and Pneumovax), but not protein vaccines such as Fluzone.	Polysaccharides	89-103	immunoglobulin heavy constant alpha	Mus musculus	15-18
28774562-4	2017	Interestingly, after immunization with live bacteria, IgA+/+ and IgA-/- mice were both resistant to lethal challenge and their IgG anti-polysaccharide antibody responses were comparable.	Polysaccharides	136-150	immunoglobulin heavy constant alpha	Mus musculus	54-57
28871157-1	2017	Plant GDP-D-mannose epimerase (GME) converts GDP-D-mannose to GDP-L-galactose, a precursor of both L-ascorbate (vitamin C) and cell wall polysaccharides.	Polysaccharides	137-152	GDP-D-mannose 3',5'-epimerase	Arabidopsis thaliana	6-29
28322582-1	2017	This study aimed to explore the contribution of high-mannose glycans in the masking of conserved V3 crown (GPG) and V2i epitopes on the hypervariable loops of most exposed distal surface of HIV-1 Env.	Polysaccharides	61-68	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	196-199
28660311-0	2017	Astragalus polysaccharides inhibits cell growth and pro-inflammatory response in IL-1beta-stimulated fibroblast-like synoviocytes by enhancement of autophagy via PI3K/AKT/mTOR inhibition.	Polysaccharides	11-26	interleukin 1 beta	Homo sapiens	81-89
28660311-0	2017	Astragalus polysaccharides inhibits cell growth and pro-inflammatory response in IL-1beta-stimulated fibroblast-like synoviocytes by enhancement of autophagy via PI3K/AKT/mTOR inhibition.	Polysaccharides	11-26	AKT serine/threonine kinase 1	Homo sapiens	167-170
28660311-0	2017	Astragalus polysaccharides inhibits cell growth and pro-inflammatory response in IL-1beta-stimulated fibroblast-like synoviocytes by enhancement of autophagy via PI3K/AKT/mTOR inhibition.	Polysaccharides	11-26	mechanistic target of rapamycin kinase	Homo sapiens	171-175
28578966-2	2017	Starch was precipitated by freeze-thaw treatment, while pectic polysaccharides (8% yield) remained soluble and consisted of GalA (67.0%), Rha (1.6%), Ara (6.4%), Xyl (0.3%), Gal (6.7%) and Glc (4.4%).	Polysaccharides	63-78	galactosidase alpha	Homo sapiens	124-128
28412343-3	2017	The predicted structure of PAP1-A was established to be a complex polysaccharide with a main chain consisted of alpha-(1 4)-linked galactose partially substituted at O-6 position, with the (1 2)-linked xylose, (1 3)-linked arabinose, (1 3)-linked rhamnose, (1 3,6)-linked mannose, and (1 6)-linked mannose, as branches.	Polysaccharides	66-80	PDGFA associated protein 1	Mus musculus	27-31
28867068-0	2017	Retraction notice to "Polysaccharide from Angelica sinensis ameliorates high-fat diet and STZ-induced hepatic oxidative stress and inflammation in diabetic mice by activating Sirt1-AMPK pathway" [JNB 43 (2017) 88-97].	Polysaccharides	22-36	sirtuin 1	Mus musculus	175-180
28667885-0	2017	Activation of murine macrophages by G1-4A, a polysaccharide from Tinospora cordifolia, in TLR4/MyD88 dependent manner.	Polysaccharides	45-59	toll-like receptor 4	Mus musculus	90-94
28667885-0	2017	Activation of murine macrophages by G1-4A, a polysaccharide from Tinospora cordifolia, in TLR4/MyD88 dependent manner.	Polysaccharides	45-59	myeloid differentiation primary response gene 88	Mus musculus	95-100
28472687-5	2017	Glycan array analysis of DBL revealed its affinity toward high mannose N-linked glycans with enhanced affinity for terminal mannose including N-linked glycans of HIV envelope glycoprotein gp120 and has strong anti-reverse transcriptase activity.	Polysaccharides	0-6	MCF.2 cell line derived transforming sequence	Homo sapiens	25-28
28472687-8	2017	Inhibitory effect of DBL was effectively blocked in presence of competing glycans like mucin.	Polysaccharides	74-81	MCF.2 cell line derived transforming sequence	Homo sapiens	21-24
28600306-1	2017	PMN-expressed fucosylated glycans from the Lewis glycan family, including Lewis-x (Lex) and sialyl Lewis-x (sLex), have previously been implicated in the regulation of important PMN functions, including selectin-mediated trafficking across vascular endothelium.	Polysaccharides	26-33	fucosyltransferase 4	Homo sapiens	74-81
28600306-1	2017	PMN-expressed fucosylated glycans from the Lewis glycan family, including Lewis-x (Lex) and sialyl Lewis-x (sLex), have previously been implicated in the regulation of important PMN functions, including selectin-mediated trafficking across vascular endothelium.	Polysaccharides	26-33	fucosyltransferase 4	Homo sapiens	83-86
28600306-1	2017	PMN-expressed fucosylated glycans from the Lewis glycan family, including Lewis-x (Lex) and sialyl Lewis-x (sLex), have previously been implicated in the regulation of important PMN functions, including selectin-mediated trafficking across vascular endothelium.	Polysaccharides	26-33	fucosyltransferase 4	Homo sapiens	99-106
28600306-1	2017	PMN-expressed fucosylated glycans from the Lewis glycan family, including Lewis-x (Lex) and sialyl Lewis-x (sLex), have previously been implicated in the regulation of important PMN functions, including selectin-mediated trafficking across vascular endothelium.	Polysaccharides	26-32	fucosyltransferase 4	Homo sapiens	74-81
28600306-1	2017	PMN-expressed fucosylated glycans from the Lewis glycan family, including Lewis-x (Lex) and sialyl Lewis-x (sLex), have previously been implicated in the regulation of important PMN functions, including selectin-mediated trafficking across vascular endothelium.	Polysaccharides	26-32	fucosyltransferase 4	Homo sapiens	83-86
28600306-1	2017	PMN-expressed fucosylated glycans from the Lewis glycan family, including Lewis-x (Lex) and sialyl Lewis-x (sLex), have previously been implicated in the regulation of important PMN functions, including selectin-mediated trafficking across vascular endothelium.	Polysaccharides	26-32	fucosyltransferase 4	Homo sapiens	99-106
28600306-2	2017	Although glycans, such as Lex and sLex, which are based on the type 2 sequence (Galbeta1-4GlcNAc-R), are abundant on PMNs, the presence of type 1 Galbeta1-3GlcNAc-R glycans required for PMN expression of the closely related stereoisomer of Lex, termed Lewis-A (Lea), has not, to our knowledge, been reported.	Polysaccharides	9-16	fucosyltransferase 4	Homo sapiens	26-29
28600306-2	2017	Although glycans, such as Lex and sLex, which are based on the type 2 sequence (Galbeta1-4GlcNAc-R), are abundant on PMNs, the presence of type 1 Galbeta1-3GlcNAc-R glycans required for PMN expression of the closely related stereoisomer of Lex, termed Lewis-A (Lea), has not, to our knowledge, been reported.	Polysaccharides	9-16	fucosyltransferase 4	Homo sapiens	35-38
28714086-13	2017	Glycosylation patterns probably differ between cell types, across development or with pathologies, and thus our findings reveal a potential mechanism for context-specific fine-tuning of KAR function through diversity in glycan structure.	Polysaccharides	220-226	KAR	Homo sapiens	186-189
28581490-12	2017	These glycan changes on MUC1 were detected with high sensitivity owing to the cluster effect of immobilized lectins on a tandem repeat peptide antigen covered with highly dense glycosylation such as mucin.	Polysaccharides	6-12	mucin 1, cell surface associated	Homo sapiens	24-28
28860481-2	2017	Sialic acid-binding immunoglobulin-type lectins 9 (Siglec-9) is predominantly expressed on innate immune cells and has been shown to exert regulatory effect on immune cells through glycan recognition.	Polysaccharides	181-187	sialic acid binding Ig like lectin 9	Homo sapiens	0-49
28915952-5	2017	The Authors suggest that anti-drug antibodies against glycan structures of TNF-alpha inhibitors may cross react against serum aberrant IgA1 leading to large antigen-antibody complexes.	Polysaccharides	54-60	tumor necrosis factor	Homo sapiens	75-84
28915952-5	2017	The Authors suggest that anti-drug antibodies against glycan structures of TNF-alpha inhibitors may cross react against serum aberrant IgA1 leading to large antigen-antibody complexes.	Polysaccharides	54-60	immunoglobulin heavy constant alpha 1	Homo sapiens	135-139
28160363-6	2017	Glycan analysis of the endogenous proteins of these lines exhibited N-linked glycans lacking beta(1,2)-xylose and/or alpha(1,3)-fucose.	Polysaccharides	0-6	adrenoceptor alpha 1D	Homo sapiens	117-126
28182326-8	2017	Analysis of genes co-expressed with GhMYB1 showed that it potentially regulates a number of other 19-25 DPA-specific genes in networks including those functioning in the cell wall and precursor synthesis, but not the major polysaccharide and protein components of the fibre SCW.	Polysaccharides	223-237	transcription repressor MYB6-like	Gossypium hirsutum	36-42
29192453-2	2017	The contents of LPS in the polysaccharides were determined by chromogenic tachypleus amebocyte lysate(TAL)method during the procedure of purifying.	Polysaccharides	27-42	transaldolase 1	Homo sapiens	102-105
28713956-1	2017	MDG-1, a water-soluble polysaccharide extracted from Ophiopogon japonicus, has been reported to serve a role in antimyocardial ischemia by protecting cardiomyocytes from hypoxia/reoxygenation-induced damage.	Polysaccharides	23-37	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	0-5
28927138-1	2017	beta-1,3-N-Acetylglucosaminyltransferase 8 (beta3GnT8) is a key enzyme that catalyzes the formation of polylactosamine glycan structures by transferring GlcNAc to tetra-antennary beta1-6-branched N-glycans, and it has been reported to participate in tumor invasion and metastasis by regulating the expression of matrix metalloproteinases (MMPs), cluster of differentiation 147 (CD147) and polylactosamine.	Polysaccharides	119-125	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	Homo sapiens	44-53
28670741-1	2017	The mechanistic underpinnings of the complex process of plant polysaccharide biosynthesis are poorly understood, largely because of the resistance of glycosyltransferase (GT) enzymes to structural characterization.	Polysaccharides	62-76	glycosyltransferase	Arabidopsis thaliana	150-169
28670741-1	2017	The mechanistic underpinnings of the complex process of plant polysaccharide biosynthesis are poorly understood, largely because of the resistance of glycosyltransferase (GT) enzymes to structural characterization.	Polysaccharides	62-76	glycosyltransferase	Arabidopsis thaliana	171-173
29043215-10	2017	Collectively, the n-Hex fraction from brown algae H. fusiformis could be a potential inhibitor of MMPs, suggesting the presence of various derivatives of polysaccharides in high amounts.	Polysaccharides	154-169	hematopoietically expressed homeobox	Homo sapiens	20-23
29043215-10	2017	Collectively, the n-Hex fraction from brown algae H. fusiformis could be a potential inhibitor of MMPs, suggesting the presence of various derivatives of polysaccharides in high amounts.	Polysaccharides	154-169	matrix metallopeptidase 2	Homo sapiens	98-102
29043221-2	2017	Two polysaccharides were extracted from red pepper stems using an autoclave and alkali treatments, and the extracts were named PAU and PAL, respectively.	Polysaccharides	4-19	leucine rich repeat, Ig-like and transmembrane domains 1	Homo sapiens	135-138
28860481-2	2017	Sialic acid-binding immunoglobulin-type lectins 9 (Siglec-9) is predominantly expressed on innate immune cells and has been shown to exert regulatory effect on immune cells through glycan recognition.	Polysaccharides	181-187	sialic acid binding Ig like lectin 9	Homo sapiens	51-59
28841174-2	2017	Two polysaccharides, DRP1 and DRP2, were isolated from DRP.	Polysaccharides	4-19	collapsin response mediator protein 1	Mus musculus	21-25
28841174-2	2017	Two polysaccharides, DRP1 and DRP2, were isolated from DRP.	Polysaccharides	4-19	dystrophin related protein 2	Mus musculus	30-34
28861345-6	2017	RESULTS: Comparison of the progressive relative changes in the sialylated glycans of retinal proteins from wt and rd1 mice showed that Siaalpha2-3Galbeta1-4GlcNAc-glycans (but not Siaalpha2-6-glycans) were detectable and quantifiable from the retinal-proteins of PN7 and PN14 wt and rd1 mice.	Polysaccharides	74-81	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	114-117
28760868-1	2017	Polysialic acid is a glycan modification of the neural cell adhesion molecule (NCAM) produced by the polysialyltransferases ST8SIA2 and ST8SIA4.	Polysaccharides	21-27	neural cell adhesion molecule 1	Mus musculus	48-77
28760868-1	2017	Polysialic acid is a glycan modification of the neural cell adhesion molecule (NCAM) produced by the polysialyltransferases ST8SIA2 and ST8SIA4.	Polysaccharides	21-27	neural cell adhesion molecule 1	Mus musculus	79-83
28607101-2	2017	This bacterium can degrade glycans into monosaccharides using two glycosidases, multisubstrate glycosidase A (MsgA) and neuraminidase (NanA).	Polysaccharides	27-34	neuraminidase 1	Homo sapiens	120-133
28607101-2	2017	This bacterium can degrade glycans into monosaccharides using two glycosidases, multisubstrate glycosidase A (MsgA) and neuraminidase (NanA).	Polysaccharides	27-34	neuraminidase 1	Homo sapiens	135-139
29104305-1	2017	The main aim of the research was to design a functional impedimetric biosensor able to glycoprofile prostate specific antigen (PSA), a biomarker for prostate cancer (PCa), with high specificity using lectins as glycan recognising proteins.	Polysaccharides	211-217	kallikrein related peptidase 3	Homo sapiens	100-125
29104305-1	2017	The main aim of the research was to design a functional impedimetric biosensor able to glycoprofile prostate specific antigen (PSA), a biomarker for prostate cancer (PCa), with high specificity using lectins as glycan recognising proteins.	Polysaccharides	211-217	kallikrein related peptidase 3	Homo sapiens	127-130
28861345-6	2017	RESULTS: Comparison of the progressive relative changes in the sialylated glycans of retinal proteins from wt and rd1 mice showed that Siaalpha2-3Galbeta1-4GlcNAc-glycans (but not Siaalpha2-6-glycans) were detectable and quantifiable from the retinal-proteins of PN7 and PN14 wt and rd1 mice.	Polysaccharides	163-170	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	114-117
28787048-1	2017	beta-1,3-Glucan is one of the most abundant polysaccharides in fungi.	Polysaccharides	44-59	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	0-8
28861345-6	2017	RESULTS: Comparison of the progressive relative changes in the sialylated glycans of retinal proteins from wt and rd1 mice showed that Siaalpha2-3Galbeta1-4GlcNAc-glycans (but not Siaalpha2-6-glycans) were detectable and quantifiable from the retinal-proteins of PN7 and PN14 wt and rd1 mice.	Polysaccharides	163-170	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	283-286
28652405-7	2017	Comparison of the binding sites in DC-SIGN and langerin, two other pathogen-binding receptors of the innate immune system, revealed why these two binding sites accommodate only terminal Manalpha1-2Man structures, whereas dectin-2 can bind Manalpha1-2Man in internal positions in mannans and other polysaccharides.	Polysaccharides	297-312	C-type lectin domain containing 6A	Homo sapiens	221-229
29100363-5	2017	In this study, we purified PSA from expressed prostate secretions (EPS)-urine samples from 32 BPH and 30 PCa patients and provided detailed PSA glycan profiles in Chinese population.	Polysaccharides	144-150	kallikrein related peptidase 3	Homo sapiens	27-30
29100363-6	2017	We found that most of the PSA glycans from EPS-urine were complex type biantennary glycans.	Polysaccharides	30-37	kallikrein related peptidase 3	Homo sapiens	26-29
29100363-6	2017	We found that most of the PSA glycans from EPS-urine were complex type biantennary glycans.	Polysaccharides	83-90	kallikrein related peptidase 3	Homo sapiens	26-29
29100363-7	2017	We observed two major patterns in PSA glycan profiles.	Polysaccharides	38-44	kallikrein related peptidase 3	Homo sapiens	34-37
28652405-7	2017	Comparison of the binding sites in DC-SIGN and langerin, two other pathogen-binding receptors of the innate immune system, revealed why these two binding sites accommodate only terminal Manalpha1-2Man structures, whereas dectin-2 can bind Manalpha1-2Man in internal positions in mannans and other polysaccharides.	Polysaccharides	297-312	CD207 molecule	Homo sapiens	47-55
28652405-8	2017	The specificity and geometry of the dectin-2-binding site provide the molecular mechanism for binding of dectin-2 to fungal mannans and also to bacterial lipopolysaccharides, capsular polysaccharides, and lipoarabinomannans that contain the Manalpha1-2Man disaccharide unit.	Polysaccharides	158-173	C-type lectin domain containing 6A	Homo sapiens	36-44
28652405-8	2017	The specificity and geometry of the dectin-2-binding site provide the molecular mechanism for binding of dectin-2 to fungal mannans and also to bacterial lipopolysaccharides, capsular polysaccharides, and lipoarabinomannans that contain the Manalpha1-2Man disaccharide unit.	Polysaccharides	158-173	C-type lectin domain containing 6A	Homo sapiens	105-113
28796164-7	2017	This is the first evidence for differences in glycan selectivity of Gal-3  and Gal-3 and may be further utilized for tracing Gal-3  during tumor progression and therapy.	Polysaccharides	46-52	galectin 3	Homo sapiens	68-73
28796164-7	2017	This is the first evidence for differences in glycan selectivity of Gal-3  and Gal-3 and may be further utilized for tracing Gal-3  during tumor progression and therapy.	Polysaccharides	46-52	galectin 3	Homo sapiens	79-84
28796164-7	2017	This is the first evidence for differences in glycan selectivity of Gal-3  and Gal-3 and may be further utilized for tracing Gal-3  during tumor progression and therapy.	Polysaccharides	46-52	galectin 3	Homo sapiens	79-84
28793911-11	2017	We found that the ratio between the main agalactosylated (FA2) and main mono- and di-galactosylated Fc glycans (FA2G1 and FA2G2) of IgG1 ranked as the most prominent factor distinguishing responders from nonresponders.	Polysaccharides	103-110	FA complementation group B	Homo sapiens	58-61
28314374-7	2017	Antibody 18F11 bound at the gp120 C-terminus (aa 445-459) and reactivity was glycan dependent.	Polysaccharides	77-83	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	28-33
28535451-1	2017	One of the most frequently used high-resolution glycan analysis methods in the biopharmaceutical and biomedical fields is capillary electrophoresis with laser-induced fluorescence (CE-LIF) detection.	Polysaccharides	48-54	LIF interleukin 6 family cytokine	Homo sapiens	184-187
28736166-5	2017	RHM1 encodes a UDP-L-rhamnose synthase, and rhm1 mutations affect synthesis of the pectic polysaccharide rhamnogalacturonan-I.	Polysaccharides	90-104	rhamnose biosynthesis 1	Arabidopsis thaliana	44-48
28824637-4	2017	These glycans interact with mannose-specific lectins, especially with dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN).	Polysaccharides	6-13	CD209 molecule	Homo sapiens	70-149
28824637-4	2017	These glycans interact with mannose-specific lectins, especially with dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN).	Polysaccharides	6-13	CD209 molecule	Homo sapiens	151-158
28824909-5	2017	Recent advances in the synthesis of polymeric ligands, the identification of physiological ligands for Siglec-8 and Siglec-F in the airway, and the determination of the basis of glycan ligand discrimination of Siglec-8 are discussed.	Polysaccharides	178-184	sialic acid binding Ig like lectin 8	Homo sapiens	210-218
28554385-2	2017	N-acetylglucosaminyltransferases I, II, IV, and V (i.e. Mgat1, Mgat2, Mgat4, and Mgat5) catalyze the formation of a glycan antennary structure.	Polysaccharides	116-122	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Cricetulus griseus	56-61
28399471-9	2017	A family of anionic, partially lipophilic sulfated polysaccharide derivatives known as semi-synthetic glycosaminoglycan ethers (SAGEs) were used in an effort to block RAGE signaling.	Polysaccharides	51-65	advanced glycosylation end-product specific receptor	Homo sapiens	167-171
28554385-2	2017	N-acetylglucosaminyltransferases I, II, IV, and V (i.e. Mgat1, Mgat2, Mgat4, and Mgat5) catalyze the formation of a glycan antennary structure.	Polysaccharides	116-122	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Cricetulus griseus	63-68
28554385-2	2017	N-acetylglucosaminyltransferases I, II, IV, and V (i.e. Mgat1, Mgat2, Mgat4, and Mgat5) catalyze the formation of a glycan antennary structure.	Polysaccharides	116-122	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A	Cricetulus griseus	81-86
28630087-10	2017	The three glycosylation sites of HNE were located distal to the active site indicating glycan functions other than interference with HNE enzyme activity.	Polysaccharides	87-93	elastase, neutrophil expressed	Homo sapiens	33-36
28442549-3	2017	We demonstrate that 2 mammalian enzymes, neuraminidases 3 and 4, play important roles in catabolic processing of brain gangliosides by cleaving terminal sialic acid residues in their glycan chains.	Polysaccharides	183-189	neuraminidase 3	Homo sapiens	41-63
28640663-12	2017	Combined percentages of afucosylated and high mannosylated glycans were positively correlated with FcgammaRIIIa binding and ADCC in NK92-CD16 cells, while no correlation was observed in PBMC.	Polysaccharides	59-66	Fc receptor, IgG, low affinity III	Mus musculus	137-141
28576849-6	2017	Yet knowledge about glycan-dependent interactors of Gal-1 and Gal-3 on RPE cells is very limited, although this is a prerequisite for unraveling the influence of galectins on distinct cellular processes in RPE cells.	Polysaccharides	20-26	galectin 1	Homo sapiens	52-57
28576849-6	2017	Yet knowledge about glycan-dependent interactors of Gal-1 and Gal-3 on RPE cells is very limited, although this is a prerequisite for unraveling the influence of galectins on distinct cellular processes in RPE cells.	Polysaccharides	20-26	galectin 3	Homo sapiens	62-67
28482115-0	2017	Arabidopsis thaliana FLA4 functions as a glycan-stabilized soluble factor via its carboxy-proximal Fasciclin 1 domain.	Polysaccharides	41-47	Fasciclin-like arabinogalactan family protein	Arabidopsis thaliana	21-25
28486782-9	2017	N-glycosylation results in the formation of several noncovalent interactions between the glycans and EGFR extracellular domain near the EGF binding site.	Polysaccharides	89-96	epidermal growth factor receptor	Homo sapiens	101-105
28486782-9	2017	N-glycosylation results in the formation of several noncovalent interactions between the glycans and EGFR extracellular domain near the EGF binding site.	Polysaccharides	89-96	epidermal growth factor	Homo sapiens	101-104
28757018-0	2017	Glycan-specificity of four neuraminidase-sensitive animal rotavirus strains.	Polysaccharides	0-6	neuraminidase 1	Bos taurus	27-40
28824326-3	2017	The fucosyltransferase-2 gene (FUT2) encodes alpha (1,2) fucosyltransferase, which is responsible for the addition of the alpha (1,2)-linkage of fucose to glycans.	Polysaccharides	155-162	fucosyltransferase 2	Homo sapiens	4-24
28751750-5	2017	The use of DC-SIGN mutants lacking the N-glycans as well as blocking glycan-mediated lateral interactions strongly impaired cell stiffening during pathogen binding.	Polysaccharides	41-47	CD209 molecule	Homo sapiens	11-18
28724349-8	2017	Most of the IMF-associated OTUs belong to the bacteria related to polysaccharide degradation and amino acid metabolism (such as Prevotella, Treponema, Bacteroides and Clostridium).	Polysaccharides	66-80	IMF	Sus scrofa	12-15
28742114-2	2017	EP-1, a purified polysaccharide isolated from HE mycelium, has recently been identified as the active component responsible for HE anti-gastritis activity.	Polysaccharides	17-31	prostaglandin E receptor 1	Homo sapiens	0-4
28742114-5	2017	A crude mycelial polysaccharide (CMPS) extract of HE, from which EP-1 was purified, showed slightly stronger radical scavenging activity and ORAC than EP-1, with the exception of DPPH-scavenging activity.	Polysaccharides	17-31	prostaglandin E receptor 1	Homo sapiens	65-69
28727758-8	2017	Chemical analysis of this extract revealed a low molecular weight polysaccharide of 1000 Da, predominantly comprising Glu1 6Glu linkage.	Polysaccharides	66-80	aconitate hydratase ACO1	Saccharomyces cerevisiae S288C	118-122
28678517-2	2017	The substrate specificity of FUT8 toward bi-antennary N-glycans has been reported, but it is unclear with regard to tri-antennary and tetra-antennary glycans.	Polysaccharides	56-63	fucosyltransferase 8	Homo sapiens	29-33
28678517-4	2017	We found that the tri-antennary glycan [A3(2,4,2) type] terminated with N-acetylglucosamine (GlcNAc), which is generated by N-acetylglucosaminyltransferase (GnT)-IV, is a good substrate for FUT8, but the A3(2,2,6) type of tri-antennary glycan, generated by GnT-V, is not a substrate for FUT8.	Polysaccharides	32-38	fucosyltransferase 8	Homo sapiens	190-194
28678517-4	2017	We found that the tri-antennary glycan [A3(2,4,2) type] terminated with N-acetylglucosamine (GlcNAc), which is generated by N-acetylglucosaminyltransferase (GnT)-IV, is a good substrate for FUT8, but the A3(2,2,6) type of tri-antennary glycan, generated by GnT-V, is not a substrate for FUT8.	Polysaccharides	32-38	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	257-262
28678517-4	2017	We found that the tri-antennary glycan [A3(2,4,2) type] terminated with N-acetylglucosamine (GlcNAc), which is generated by N-acetylglucosaminyltransferase (GnT)-IV, is a good substrate for FUT8, but the A3(2,2,6) type of tri-antennary glycan, generated by GnT-V, is not a substrate for FUT8.	Polysaccharides	32-38	fucosyltransferase 8	Homo sapiens	287-291
28678517-4	2017	We found that the tri-antennary glycan [A3(2,4,2) type] terminated with N-acetylglucosamine (GlcNAc), which is generated by N-acetylglucosaminyltransferase (GnT)-IV, is a good substrate for FUT8, but the A3(2,2,6) type of tri-antennary glycan, generated by GnT-V, is not a substrate for FUT8.	Polysaccharides	236-242	fucosyltransferase 8	Homo sapiens	190-194
28678517-4	2017	We found that the tri-antennary glycan [A3(2,4,2) type] terminated with N-acetylglucosamine (GlcNAc), which is generated by N-acetylglucosaminyltransferase (GnT)-IV, is a good substrate for FUT8, but the A3(2,2,6) type of tri-antennary glycan, generated by GnT-V, is not a substrate for FUT8.	Polysaccharides	236-242	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	257-262
28678517-4	2017	We found that the tri-antennary glycan [A3(2,4,2) type] terminated with N-acetylglucosamine (GlcNAc), which is generated by N-acetylglucosaminyltransferase (GnT)-IV, is a good substrate for FUT8, but the A3(2,2,6) type of tri-antennary glycan, generated by GnT-V, is not a substrate for FUT8.	Polysaccharides	236-242	fucosyltransferase 8	Homo sapiens	287-291
28678517-5	2017	We also observed that core fucosylation reduced the activity of GnT-IV toward the bi-antennary glycan.	Polysaccharides	95-101	alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B	Homo sapiens	64-70
28824326-3	2017	The fucosyltransferase-2 gene (FUT2) encodes alpha (1,2) fucosyltransferase, which is responsible for the addition of the alpha (1,2)-linkage of fucose to glycans.	Polysaccharides	155-162	fucosyltransferase 2	Homo sapiens	31-35
28824326-3	2017	The fucosyltransferase-2 gene (FUT2) encodes alpha (1,2) fucosyltransferase, which is responsible for the addition of the alpha (1,2)-linkage of fucose to glycans.	Polysaccharides	155-162	fucosyltransferase 2	Homo sapiens	45-75
28700033-0	2017	Astragalus polysaccharides improve cardiomyopathy in STZ-induced diabetic mice and heterozygous (SOD2+/-) knockout mice.	Polysaccharides	11-26	superoxide dismutase 2, mitochondrial	Mus musculus	97-101
28692034-2	2017	Fucosyltransferase IV (FUT4) is the key enzyme catalyzing the biosynthesis of alpha1,3-linkage fucosylated glycans carried by glycoproteins on the cell surface, such as the tumor-associated sugar antigen Lewis Y (LeY).	Polysaccharides	107-114	fucosyltransferase 4	Homo sapiens	0-21
28692034-2	2017	Fucosyltransferase IV (FUT4) is the key enzyme catalyzing the biosynthesis of alpha1,3-linkage fucosylated glycans carried by glycoproteins on the cell surface, such as the tumor-associated sugar antigen Lewis Y (LeY).	Polysaccharides	107-114	fucosyltransferase 4	Homo sapiens	23-27
28512129-2	2017	We recently discovered that the cadherin superfamily carries O-linked mannose (O-Man) glycans at highly conserved residues in specific extracellular cadherin domains, and it was suggested that the function of E-cadherin was dependent on the O-Man glycans.	Polysaccharides	86-93	cadherin 1	Homo sapiens	32-40
28512129-2	2017	We recently discovered that the cadherin superfamily carries O-linked mannose (O-Man) glycans at highly conserved residues in specific extracellular cadherin domains, and it was suggested that the function of E-cadherin was dependent on the O-Man glycans.	Polysaccharides	86-93	cadherin 1	Homo sapiens	209-219
28614667-8	2017	Characterization of peptide-binding affinities of purified N   Q CTR ECD glycan site mutants combined with PNGase F and Endo H treatment strategies and mass spectrometry to define the glycan species indicated that a single GlcNAc residue at CTR N130 was responsible for the peptide affinity enhancement.	Polysaccharides	73-79	calcitonin receptor	Homo sapiens	65-68
29109592-6	2017	It also covers electrochemical methods based on the enzyme-like activity of PSA, on DNA-, aptamer- and biofuel cell-based methods, and on the detection of PSA via its glycan part.	Polysaccharides	167-173	kallikrein related peptidase 3	Homo sapiens	155-158
28978092-9	2017	Native glycan fragments were significantly linked to the expression of EGFR, HER2/neu and MIB1.	Polysaccharides	7-13	epidermal growth factor receptor	Homo sapiens	71-75
28978092-9	2017	Native glycan fragments were significantly linked to the expression of EGFR, HER2/neu and MIB1.	Polysaccharides	7-13	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-81
28978092-9	2017	Native glycan fragments were significantly linked to the expression of EGFR, HER2/neu and MIB1.	Polysaccharides	7-13	erb-b2 receptor tyrosine kinase 2	Homo sapiens	82-85
28978092-9	2017	Native glycan fragments were significantly linked to the expression of EGFR, HER2/neu and MIB1.	Polysaccharides	7-13	MIB E3 ubiquitin protein ligase 1	Homo sapiens	90-94
28747866-0	2017	Polysaccharide from wheat bran induces cytokine expression via the toll-like receptor 4-mediated p38 MAPK signaling pathway and prevents cyclophosphamide-induced immunosuppression in mice.	Polysaccharides	0-14	mitogen-activated protein kinase 14	Mus musculus	97-100
28433181-1	2017	A water-soluble polysaccharide SPS2p was isolated from the whole grass of Scutellaria barbata and SPS2p contained 53.6% carbohydrates, 38.5% uronic acid and 8.2% proteins.	Polysaccharides	16-30	selenophosphate synthetase 2	Homo sapiens	31-36
28218815-6	2017	Azide-modified ManNAc analogues widely used in MGE also enhanced esterase activity and provided a way to enrich targeted glycoengineered proteins (such as CES2), thereby providing unambiguous evidence that the compounds were converted to sialosides and installed into the glycan structures of esterases as intended.	Polysaccharides	272-278	carboxylesterase 2	Homo sapiens	155-159
27565716-0	2017	Effect in virulence of switching conserved homologous capsular polysaccharide genes from Klebsiella pneumoniae serotype K1 into K20.	Polysaccharides	63-77	keratin 20	Mus musculus	128-131
28683291-1	2017	Glycogenin is considered essential for glycogen synthesis, as it acts as a primer for the initiation of the polysaccharide chain.	Polysaccharides	108-122	glycogenin	Mus musculus	0-10
28186328-5	2017	Furthermore, 54-60% of the intracellular protein was characterized by Man8 and Man9 glycans on day 10, when the cell density peaks, indicative of a significant bottleneck between the endoplasmic reticulum (ER) and the cis-Golgi.	Polysaccharides	84-91	mannosidase alpha class 1A member 1	Homo sapiens	79-83
28186328-7	2017	Glucose deprivation caused a reduction in the Man8 and Man9 glycans in favor of Man5 glycans and bi-antennary-fucosylated GlcNAc-terminated residues in the organellar pool of the Fc-fusion protein.	Polysaccharides	60-67	mannosidase alpha class 1A member 1	Homo sapiens	55-59
28495148-5	2017	Although urine is a simpler matrix for analyzing PSA glycosylation compared to serum, an immunopurification step was necessary to specifically detect the glycans on the PSA molecule.	Polysaccharides	154-161	kallikrein related peptidase 3	Homo sapiens	169-172
28433181-1	2017	A water-soluble polysaccharide SPS2p was isolated from the whole grass of Scutellaria barbata and SPS2p contained 53.6% carbohydrates, 38.5% uronic acid and 8.2% proteins.	Polysaccharides	16-30	selenophosphate synthetase 2	Homo sapiens	98-103
28553948-5	2017	We demonstrate the utility of this strategy by isolating Staphylococcus aureus Lipid II and reconstituting the synthesis of crosslinked peptidoglycan by the essential penicillin-binding protein 2 (PBP2), which catalyzes both glycan polymerization and transpeptidation.	Polysaccharides	143-149	AT695_RS10295	Staphylococcus aureus	167-195
28369504-4	2017	Glycan array analyses demonstrated that Siglec-8, Siglec-9 and their mouse counterparts Siglec-F and Siglec-E (respectively) have distinct glycan binding specificities, with Siglec-8 more structurally restricted.	Polysaccharides	139-145	sialic acid binding Ig-like lectin F	Mus musculus	88-96
28369504-4	2017	Glycan array analyses demonstrated that Siglec-8, Siglec-9 and their mouse counterparts Siglec-F and Siglec-E (respectively) have distinct glycan binding specificities, with Siglec-8 more structurally restricted.	Polysaccharides	139-145	sialic acid binding Ig-like lectin E	Mus musculus	101-109
28369504-10	2017	These data reveal differential glycan specificities of Siglec-8, Siglec-9 and their mouse counterparts Siglec-F and Siglec-E, and the tissue distributions and molecular characteristics of Siglec-8 and Siglec-9 sialoglycan ligands on human airways and lungs.	Polysaccharides	31-37	sialic acid binding Ig like lectin 8	Homo sapiens	55-63
28566370-2	2017	Removal of the core fucose of this glycan greatly increases the affinity for FcgammaRIII, resulting in enhanced FcgammaRIII-mediated effector functions.	Polysaccharides	35-41	Fc gamma receptor IIIa	Homo sapiens	77-88
28566370-2	2017	Removal of the core fucose of this glycan greatly increases the affinity for FcgammaRIII, resulting in enhanced FcgammaRIII-mediated effector functions.	Polysaccharides	35-41	Fc gamma receptor IIIa	Homo sapiens	112-123
28369504-4	2017	Glycan array analyses demonstrated that Siglec-8, Siglec-9 and their mouse counterparts Siglec-F and Siglec-E (respectively) have distinct glycan binding specificities, with Siglec-8 more structurally restricted.	Polysaccharides	0-6	sialic acid binding Ig like lectin 8	Homo sapiens	40-48
28369504-4	2017	Glycan array analyses demonstrated that Siglec-8, Siglec-9 and their mouse counterparts Siglec-F and Siglec-E (respectively) have distinct glycan binding specificities, with Siglec-8 more structurally restricted.	Polysaccharides	0-6	sialic acid binding Ig-like lectin E	Mus musculus	50-58
28369504-4	2017	Glycan array analyses demonstrated that Siglec-8, Siglec-9 and their mouse counterparts Siglec-F and Siglec-E (respectively) have distinct glycan binding specificities, with Siglec-8 more structurally restricted.	Polysaccharides	0-6	sialic acid binding Ig-like lectin F	Mus musculus	88-96
28369504-4	2017	Glycan array analyses demonstrated that Siglec-8, Siglec-9 and their mouse counterparts Siglec-F and Siglec-E (respectively) have distinct glycan binding specificities, with Siglec-8 more structurally restricted.	Polysaccharides	0-6	sialic acid binding Ig-like lectin E	Mus musculus	101-109
28369504-4	2017	Glycan array analyses demonstrated that Siglec-8, Siglec-9 and their mouse counterparts Siglec-F and Siglec-E (respectively) have distinct glycan binding specificities, with Siglec-8 more structurally restricted.	Polysaccharides	139-145	sialic acid binding Ig like lectin 8	Homo sapiens	40-48
28369504-4	2017	Glycan array analyses demonstrated that Siglec-8, Siglec-9 and their mouse counterparts Siglec-F and Siglec-E (respectively) have distinct glycan binding specificities, with Siglec-8 more structurally restricted.	Polysaccharides	139-145	sialic acid binding Ig-like lectin E	Mus musculus	50-58
28553948-5	2017	We demonstrate the utility of this strategy by isolating Staphylococcus aureus Lipid II and reconstituting the synthesis of crosslinked peptidoglycan by the essential penicillin-binding protein 2 (PBP2), which catalyzes both glycan polymerization and transpeptidation.	Polysaccharides	143-149	AT695_RS10295	Staphylococcus aureus	197-201
28271508-2	2017	In this study, we investigated the age-related molecular changes of PNNs using monoclonal antibody Cat-315, which recognizes human natural killer-1 (HNK-1) glycan on aggrecan-based PNNs.	Polysaccharides	156-162	beta-1,3-glucuronyltransferase 1	Homo sapiens	149-154
27942976-2	2017	In this work, the activity of beta-galactosidase (EC 3.2.1.23), a cell-wall-bound enzyme known to degrade the wall polysaccharides, has been demonstrated to remarkably enhance during senescence-induced loss in photosynthesis in Arabidopsis thaliana.	Polysaccharides	115-130	galactosidase beta 1	Homo sapiens	30-48
27987037-10	2017	These results provide genetic evidence for the involvement of PMM genes in the biosynthesis of AsA and polysaccharides and the mediation of PMM genes in abiotic stress tolerance during seed germination in A. thaliana.	Polysaccharides	103-118	phosphomannomutase	Arabidopsis thaliana	62-65
28665310-6	2017	The CD4+ T cells exhibited increased T-bet expression in response to ArtinM, and IL-2 production by CD4+ and CD8+ T cells depended on the recognition of CD3epsilongamma-chain glycans by ArtinM.	Polysaccharides	175-182	interleukin 2	Homo sapiens	81-85
28667249-1	2017	To better understand the conformational properties of the glycan shield covering the surface of the HIV gp120/gp41 envelope (Env) trimer, and how the glycan shield impacts the accessibility of the underlying protein surface, we performed enhanced sampling molecular dynamics (MD) simulations of a model glycosylated HIV Env protein and related systems.	Polysaccharides	58-64	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	104-109
28667249-1	2017	To better understand the conformational properties of the glycan shield covering the surface of the HIV gp120/gp41 envelope (Env) trimer, and how the glycan shield impacts the accessibility of the underlying protein surface, we performed enhanced sampling molecular dynamics (MD) simulations of a model glycosylated HIV Env protein and related systems.	Polysaccharides	58-64	endogenous retrovirus group K member 20	Homo sapiens	125-128
28895363-3	2017	The detailed structures of individual glycans between anti-EGFR monoclonal antibodies produced by different expression systems were successfully characterized at the level of free oligosaccharides using liquid chromatography electrospray ionization quadrupole time-of-fight mass spectrometry (LC-ESI-QTof MS).	Polysaccharides	38-45	epidermal growth factor receptor	Cricetulus griseus	59-63
28895363-6	2017	We confirmed that anti-EGFR antibody produced by SP2/0 cell expression system had a much more diverse mixture of glycans with alpha-Gal and an undesired, aberrant form of sialylation N-glycolylneuraminic acid (NGNA).	Polysaccharides	113-120	epidermal growth factor receptor	Mus musculus	23-27
28452462-0	2017	Glycan Remodeling of Human Erythropoietin (EPO) Through Combined Mammalian Cell Engineering and Chemoenzymatic Transglycosylation.	Polysaccharides	0-6	erythropoietin	Homo sapiens	27-41
28452462-0	2017	Glycan Remodeling of Human Erythropoietin (EPO) Through Combined Mammalian Cell Engineering and Chemoenzymatic Transglycosylation.	Polysaccharides	0-6	erythropoietin	Homo sapiens	43-46
28541706-2	2017	The strategy was first studied and optimized with simple peptides and GPI glycans, which offered excellent yields of the desired conjugates in both organic and aqueous solvents.	Polysaccharides	74-81	glucose-6-phosphate isomerase	Homo sapiens	70-73
28543910-0	2017	Wheatgrass-Derived Polysaccharide Has Antiinflammatory, Anti-Oxidative and Anti-Apoptotic Effects on LPS-Induced Hepatic Injury in Mice.	Polysaccharides	19-33	toll-like receptor 4	Mus musculus	101-104
28543910-4	2017	Mice were pre-treated with WGP (100 or 200 mg/kg daily for 2 days) and then challenged with LPS (1 mg/kg, intraperitoneal), and sacrificed after 12 h. Wheatgrass-derived polysaccharide decreased serum aminotransferase levels and histological changes as compared with LPS-challenged mice.	Polysaccharides	170-184	toll-like receptor 4	Mus musculus	267-270
28495858-5	2017	We discover that the human homolog of RNase 1 has a pH optimum for catalysis, ability to degrade double-stranded RNA, and affinity for cell-surface glycans that are distinctly higher than those of its homologs.	Polysaccharides	148-155	ribonuclease A family member 1, pancreatic	Homo sapiens	38-45
28446609-2	2017	Glycans partially shield Env from recognition by the host immune system and also are believed to be indispensable for proper folding of gp120 and for viral infectivity.	Polysaccharides	0-7	endogenous retrovirus group W member 1, envelope	Homo sapiens	25-28
28446609-2	2017	Glycans partially shield Env from recognition by the host immune system and also are believed to be indispensable for proper folding of gp120 and for viral infectivity.	Polysaccharides	0-7	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	136-141
28446609-5	2017	Therefore, using an alternative approach, we combined evolutionary information with structure-guided design and yeast surface display to produce properly cleaved HIV-1 Env variants that lack all 15 core gp120 glycans, yet retain conformational integrity and multiple-cycle viral infectivity and bind to several broadly neutralizing antibodies (bNAbs), including trimer-specific antibodies and a germline-reverted version of the bNAb VRC01.	Polysaccharides	209-216	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	168-171
28446609-8	2017	Glycan-deficient Env derivatives can be used as priming immunogens because they should engage and activate a more divergent set of germlines than fully glycosylated Env.	Polysaccharides	0-6	endogenous retrovirus group W member 1, envelope	Homo sapiens	17-20
28446609-8	2017	Glycan-deficient Env derivatives can be used as priming immunogens because they should engage and activate a more divergent set of germlines than fully glycosylated Env.	Polysaccharides	0-6	endogenous retrovirus group W member 1, envelope	Homo sapiens	165-168
28537279-0	2017	Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins.	Polysaccharides	34-41	glucose-6-phosphate isomerase	Homo sapiens	45-48
28537279-0	2017	Synthesis of biotin-labelled core glycans of GPI anchors and their application in the study of GPI interaction with pore-forming bacterial toxins.	Polysaccharides	34-41	glucose-6-phosphate isomerase	Homo sapiens	95-98
28537279-1	2017	A convergent strategy was developed for the first-time synthesis of biotin-labeled GPI core glycans.	Polysaccharides	92-99	glucose-6-phosphate isomerase	Homo sapiens	83-86
28363124-2	2017	Dense glycosylation at the outer domain of Env constrains normal enzymatic processing, stalling the glycans at immature oligomannose-type structures.	Polysaccharides	100-107	endogenous retrovirus group K member 20	Homo sapiens	43-46
28638886-11	2017	mRNA microarray had significant effect on the protein group and the polysaccharide group in regulating the water transport, among which the most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and AQP3 respectively.	Polysaccharides	68-82	fatty acid binding protein 6	Rattus norvegicus	166-171
28638886-11	2017	mRNA microarray had significant effect on the protein group and the polysaccharide group in regulating the water transport, among which the most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and AQP3 respectively.	Polysaccharides	68-82	solute carrier family 51 subunit alpha	Rattus norvegicus	173-179
28638886-11	2017	mRNA microarray had significant effect on the protein group and the polysaccharide group in regulating the water transport, among which the most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and AQP3 respectively.	Polysaccharides	68-82	solute carrier family 51 subunit beta	Rattus norvegicus	181-187
28638886-11	2017	mRNA microarray had significant effect on the protein group and the polysaccharide group in regulating the water transport, among which the most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and AQP3 respectively.	Polysaccharides	68-82	solute carrier family 11 member 2	Rattus norvegicus	189-196
28638886-11	2017	mRNA microarray had significant effect on the protein group and the polysaccharide group in regulating the water transport, among which the most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and AQP3 respectively.	Polysaccharides	68-82	solute carrier family 4 member 10	Rattus norvegicus	198-205
28638886-11	2017	mRNA microarray had significant effect on the protein group and the polysaccharide group in regulating the water transport, among which the most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and AQP3 respectively.	Polysaccharides	68-82	aquaporin 3 (Gill blood group)	Rattus norvegicus	210-214
28336547-0	2017	Glycans in the intestinal peptide transporter PEPT1 contribute to function and protect from proteolysis.	Polysaccharides	0-7	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	46-51
28355590-1	2017	This study was to investigate the synergistic effects of polysaccharides with the molecular weight more than 80kDa (OTPS1) and polyphenols (OTP) isolated from oolong tea on hepatocellular carcinoma (HCC) in vitro and in vivo.	Polysaccharides	57-72	orthopedia homeobox	Homo sapiens	116-119
28482337-4	2017	These analyses reveal how some lectins (e.g., human intelectin-1) can recognize glycan epitopes that are remarkably diverse, yet still differentiate between mammalian and microbial glycans.	Polysaccharides	80-86	intelectin 1	Homo sapiens	52-64
28482337-4	2017	These analyses reveal how some lectins (e.g., human intelectin-1) can recognize glycan epitopes that are remarkably diverse, yet still differentiate between mammalian and microbial glycans.	Polysaccharides	181-188	intelectin 1	Homo sapiens	52-64
28188799-8	2017	The backbone of the polysaccharide moiety of MTW was the same as MT2-A (Li et al.	Polysaccharides	20-34	metallothionein 2A	Homo sapiens	65-70
28427937-3	2017	A branching enzyme for O-mannosyl glycans (GnT-IX, Core M2 synthase) exhibits brain-specific expression, and the product core M2 glycans are also limited to the brain.	Polysaccharides	34-41	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B	Homo sapiens	43-49
28370891-0	2017	ADAMTS-13 glycans and conformation-dependent activity.	Polysaccharides	10-17	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	0-9
28370891-2	2017	The activity of glycan modified ADAMTS-13 was investigated under static and shear stress conditions.	Polysaccharides	16-22	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	32-41
28370891-3	2017	Terminal sialic acid on the metalloprotease domain glycans are important for ADAMTS-13 activity.	Polysaccharides	51-58	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	77-86
28370891-4	2017	The CUB domain glycans modulate ADAMTS-13 activity.	Polysaccharides	15-22	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	32-41
28370891-8	2017	The proteolytic activity of glycan-modified ADAMTS-13 was assessed under static and shear stress conditions.	Polysaccharides	28-34	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	44-53
28370891-10	2017	Using truncated ADAMTS-13, we demonstrated that this was attributable to loss of sialic acid from the glycans in the metalloprotease domain and an effect of N-linked glycosylation in the TSP2 through to CUB domains.	Polysaccharides	102-109	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	16-25
28174084-0	2017	Protective effect of polysaccharide from maca (Lepidium meyenii) on Hep-G2 cells and alcoholic liver oxidative injury in mice.	Polysaccharides	21-35	DNL-type zinc finger	Homo sapiens	68-71
28174084-1	2017	To study the characterization and hepatoprotective activity of polysaccharide from maca (Lepidium meyenii), the main polysaccharide from maca (MP-1) was obtained by DEAE-52 cellulose column.	Polysaccharides	63-77	pitrilysin metallopeptidase 1	Homo sapiens	143-147
28174084-1	2017	To study the characterization and hepatoprotective activity of polysaccharide from maca (Lepidium meyenii), the main polysaccharide from maca (MP-1) was obtained by DEAE-52 cellulose column.	Polysaccharides	117-131	pitrilysin metallopeptidase 1	Homo sapiens	143-147
28174084-2	2017	The average molecular weight of MP-1 was 1067.3kDa and the polysaccharide purity was 91.63%.	Polysaccharides	59-73	pitrilysin metallopeptidase 1	Homo sapiens	32-36
28457719-6	2017	Also recent studies suggest that GA is capable of processing substrates that lack a chitobiose (Glycan, N-acetylchiobios, NAcGlc) moiety, by its exo-hydrolase activity.	Polysaccharides	96-102	aspartylglucosaminidase	Homo sapiens	33-35
28427937-4	2017	In a previous study, we showed that cuprizone-induced demyelination increased HNK-1-capped core M2 glycan expression, while GnT-IX deficiency ameliorated demyelination, suggesting that these glycans could be useful diagnostic markers for demyelination status and act as therapeutic targets.	Polysaccharides	99-105	beta-1,3-glucuronyltransferase 1	Homo sapiens	78-83
28427937-4	2017	In a previous study, we showed that cuprizone-induced demyelination increased HNK-1-capped core M2 glycan expression, while GnT-IX deficiency ameliorated demyelination, suggesting that these glycans could be useful diagnostic markers for demyelination status and act as therapeutic targets.	Polysaccharides	191-198	beta-1,3-glucuronyltransferase 1	Homo sapiens	78-83
28427937-6	2017	In the present study, we chemoenzymatically synthesized HNK-1-capped core M2 glycans for antibody production, and confirmed that the resulting immune sera reacted with HNK-1-capped core M2 glycans.	Polysaccharides	77-84	beta-1,3-glucuronyltransferase 1	Homo sapiens	56-61
28427937-6	2017	In the present study, we chemoenzymatically synthesized HNK-1-capped core M2 glycans for antibody production, and confirmed that the resulting immune sera reacted with HNK-1-capped core M2 glycans.	Polysaccharides	189-196	beta-1,3-glucuronyltransferase 1	Homo sapiens	56-61
28427937-6	2017	In the present study, we chemoenzymatically synthesized HNK-1-capped core M2 glycans for antibody production, and confirmed that the resulting immune sera reacted with HNK-1-capped core M2 glycans.	Polysaccharides	189-196	beta-1,3-glucuronyltransferase 1	Homo sapiens	168-173
28427937-7	2017	We then examined several HNK-1-related antibodies, including the Cat-315 antibody, for reactions with HNK-1-capped core M2 glycans.	Polysaccharides	123-130	beta-1,3-glucuronyltransferase 1	Homo sapiens	25-30
28427937-7	2017	We then examined several HNK-1-related antibodies, including the Cat-315 antibody, for reactions with HNK-1-capped core M2 glycans.	Polysaccharides	123-130	beta-1,3-glucuronyltransferase 1	Homo sapiens	102-107
28548638-3	2017	Broadly neutralizing antibodies (bNAbs) against V1V2 loops, exemplified by PG9, bind asymmetrically as a single Fab to the apex of the symmetric Env trimer using a protruding CDRH3 to penetrate the Env glycan shield.	Polysaccharides	202-208	FA complementation group B	Homo sapiens	112-115
28548638-3	2017	Broadly neutralizing antibodies (bNAbs) against V1V2 loops, exemplified by PG9, bind asymmetrically as a single Fab to the apex of the symmetric Env trimer using a protruding CDRH3 to penetrate the Env glycan shield.	Polysaccharides	202-208	endogenous retrovirus group K member 20	Homo sapiens	145-148
28548638-3	2017	Broadly neutralizing antibodies (bNAbs) against V1V2 loops, exemplified by PG9, bind asymmetrically as a single Fab to the apex of the symmetric Env trimer using a protruding CDRH3 to penetrate the Env glycan shield.	Polysaccharides	202-208	endogenous retrovirus group K member 20	Homo sapiens	198-201
28548638-6	2017	Analyses of the EM structures provided information relevant to vaccine design including molecular details for different modes of asymmetric recognition of Env trimer and a binding model for BG1 recognition of V1V2 involving glycan flexibility.	Polysaccharides	224-230	acyl-CoA synthetase bubblegum family member 1	Homo sapiens	190-193
28455954-6	2017	In addition, OIR induced remodelling of cell surface glycophenotype leading to exposure of galectin-1-specific glycan epitopes.	Polysaccharides	111-117	galectin 1	Homo sapiens	91-101
28534482-3	2017	We show that Fbs1 is able to bind diverse types of N-linked glycomolecules; however, wild-type Fbs1 preferentially binds high-mannose-containing glycans.	Polysaccharides	145-152	fibrosin	Homo sapiens	13-17
28534482-3	2017	We show that Fbs1 is able to bind diverse types of N-linked glycomolecules; however, wild-type Fbs1 preferentially binds high-mannose-containing glycans.	Polysaccharides	145-152	fibrosin	Homo sapiens	95-99
28559971-0	2017	Astragalus polysaccharides attenuates TNF-alpha-induced insulin resistance via suppression of miR-721 and activation of PPAR-gamma and PI3K/AKT in 3T3-L1 adipocytes.	Polysaccharides	11-26	tumor necrosis factor	Mus musculus	38-47
28514685-2	2017	Neutralizing antibodies that target the V1V2 apex of the HIV-1 envelope (Env) trimer feature unusually long protruding loops, which enable them to penetrate the HIV-1 glycan shield.	Polysaccharides	167-173	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	73-76
28559971-0	2017	Astragalus polysaccharides attenuates TNF-alpha-induced insulin resistance via suppression of miR-721 and activation of PPAR-gamma and PI3K/AKT in 3T3-L1 adipocytes.	Polysaccharides	11-26	microRNA 721	Mus musculus	94-101
28559971-0	2017	Astragalus polysaccharides attenuates TNF-alpha-induced insulin resistance via suppression of miR-721 and activation of PPAR-gamma and PI3K/AKT in 3T3-L1 adipocytes.	Polysaccharides	11-26	peroxisome proliferator activated receptor gamma	Mus musculus	120-130
28559971-0	2017	Astragalus polysaccharides attenuates TNF-alpha-induced insulin resistance via suppression of miR-721 and activation of PPAR-gamma and PI3K/AKT in 3T3-L1 adipocytes.	Polysaccharides	11-26	thymoma viral proto-oncogene 1	Mus musculus	140-143
28363873-0	2017	Production of recombinant human acid alpha-glucosidase with high-mannose glycans in gnt1 rice for the treatment of Pompe disease.	Polysaccharides	73-80	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	84-88
28325338-1	2017	This study aimed to investigate the physicochemical properties and antidiabetic effects of a polysaccharide obtained from corn silk (PCS2).	Polysaccharides	93-107	dominant cataract 4	Mus musculus	133-137
28279966-0	2017	Plasmin Cleaves Von Willebrand Factor at K1491-R1492 in the A1-A2 Linker Region in a Shear- and Glycan-Dependent Manner In Vitro.	Polysaccharides	96-102	plasminogen	Homo sapiens	0-7
28471403-5	2017	Flavivirus envelope proteins are N-glycosylated surface proteins, which interact with C-type lectins, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) through their glycans.	Polysaccharides	206-213	CD209 molecule	Homo sapiens	102-181
28471403-5	2017	Flavivirus envelope proteins are N-glycosylated surface proteins, which interact with C-type lectins, dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) through their glycans.	Polysaccharides	206-213	CD209 molecule	Homo sapiens	183-190
28473713-9	2017	Surface plasmon resonance and glycan array analysis showed that the SubBDeltaS106/DeltaT107 mutant displayed improved specificity towards Neu5Gc and bound to alpha2-6-linked Neu5Gc.	Polysaccharides	30-36	immunoglobulin binding protein 1	Homo sapiens	158-166
28280844-8	2017	Combining the isomer resolution of HPAE with MS2 permitted thorough N-glycan annotation and led to characterization of 17 new structures from glycoproteins with challenging glycan profiles.	Polysaccharides	70-76	MS2	Homo sapiens	45-48
29926586-8	2017	Compared with the model group, the serum levels of IL-6 in the dandelion polysaccharide group and the methacetin group were significantly decreased (P&lt;0.01).	Polysaccharides	73-87	interleukin 6	Rattus norvegicus	51-55
29926586-9	2017	Compared with the model group, the MPO positive density of the rats in the dandelion polysaccharide group and the methacetin group was significantly lower than that in the normal group (P&lt;0.01).	Polysaccharides	85-99	myeloperoxidase	Rattus norvegicus	35-38
29926586-11	2017	Compared with the model group, the expressions of STAT3 and IL-6 mRNA in the intestinal tissue of the rats in the dandelion polysaccharide group and the methacetin group were decreased significantly.	Polysaccharides	124-138	signal transducer and activator of transcription 3	Rattus norvegicus	50-55
29926586-11	2017	Compared with the model group, the expressions of STAT3 and IL-6 mRNA in the intestinal tissue of the rats in the dandelion polysaccharide group and the methacetin group were decreased significantly.	Polysaccharides	124-138	interleukin 6	Rattus norvegicus	60-64
28296340-12	2017	Further, in addition to binding to the zona pellucida, lactadherin is now implicated in binding to oviduct glycans to promote formation of the sperm reservoir.	Polysaccharides	107-114	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	55-66
28279966-0	2017	Plasmin Cleaves Von Willebrand Factor at K1491-R1492 in the A1-A2 Linker Region in a Shear- and Glycan-Dependent Manner In Vitro.	Polysaccharides	96-102	von Willebrand factor	Homo sapiens	16-37
28189790-1	2017	New derivatives of gellan gum (GG) were prepared by covalent attachment of octadecylamine (C18-NH2) to polysaccharide backbone via amide linkage by using bis(4-nitrophenyl) carbonate (4-NPBC) as a coupling agent.	Polysaccharides	103-117	Bardet-Biedl syndrome 9	Homo sapiens	91-94
28108410-1	2017	Ganoderma atrum polysaccharide (PSG-1), a main polysaccharide from Ganoderma atrum, possesses potent antioxidant capacity and cardiovascular benefits.	Polysaccharides	16-30	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	32-37
27942748-4	2017	Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces.	Polysaccharides	107-113	complement factor H	Homo sapiens	0-8
28279889-0	2017	RETRACTED: Polysaccharide from Angelica sinensis ameliorates high-fat diet and STZ-induced hepatic oxidative stress and inflammation in diabetic mice by activating the Sirt1-AMPK pathway.	Polysaccharides	11-25	sirtuin 1	Mus musculus	168-173
28115227-6	2017	Histology and immunohistochemistry results further confirmed that the application of PGPSD polysaccharide partially restored the pancreatic islets in diabetic mice, and enhanced the expression of pancreatic duodenal homeobox-1, insulin and hexokinase1.	Polysaccharides	91-105	hexokinase 1	Mus musculus	240-251
28165193-0	2017	Polysaccharides L900/2 and L900/3 isolated from Lactobacillus rhamnosus LOCK 0900 modulate allergic sensitization to ovalbumin in a mouse model.	Polysaccharides	0-15	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	117-126
28281872-3	2017	We have identified novel antibodies that specifically target with high affinity the STn glycan independent of its carrier protein, affording the potential to recognize a wider array of cancer-specific sialylated proteins.	Polysaccharides	88-94	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	84-87
28165193-1	2017	Here, we compared the abilities of polysaccharides L900/2 and L900/3, which were previously isolated from Lactobacillus rhamnosus LOCK 0900, to modulate the immune response to bystander antigens in a mouse model of ovalbumin (OVA) sensitization.	Polysaccharides	35-50	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	215-224
28165193-2	2017	In vivo, both polysaccharides reduced the levels of OVA-specific IgE, IgE-dependent basophil degranulation and IgG2a antibodies, but had no effect on the levels of OVA-specific IgA or IgG1.	Polysaccharides	14-29	immunoglobulin heavy variable V1-9	Mus musculus	111-116
28323063-4	2017	We find that ER lipid saturation sensors induce expression of FLO1 - encoding a cell wall polysaccharide binding protein - independently of its canonical regulator.	Polysaccharides	90-104	flocculin FLO1	Saccharomyces cerevisiae S288C	62-66
28445724-1	2017	While the HIV-1-glycan shield is known to shelter Env from the humoral immune response, its quantitative impact on antibody elicitation has been unclear.	Polysaccharides	16-22	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	50-53
27324471-6	2017	Glycan-targeted drugs that may act to neutralize Gd-IgA1 inhibit abnormal enzymatic glycosylation of IgA1 or deplete cells producing Gd-IgA1.	Polysaccharides	0-6	immunoglobulin heavy constant alpha 1	Homo sapiens	52-56
27324471-6	2017	Glycan-targeted drugs that may act to neutralize Gd-IgA1 inhibit abnormal enzymatic glycosylation of IgA1 or deplete cells producing Gd-IgA1.	Polysaccharides	0-6	immunoglobulin heavy constant alpha 1	Homo sapiens	101-105
27324471-6	2017	Glycan-targeted drugs that may act to neutralize Gd-IgA1 inhibit abnormal enzymatic glycosylation of IgA1 or deplete cells producing Gd-IgA1.	Polysaccharides	0-6	immunoglobulin heavy constant alpha 1	Homo sapiens	101-105
28279830-0	2017	Effects of partially dismantling the CD4 binding site glycan fence of HIV-1 Envelope glycoprotein trimers on neutralizing antibody induction.	Polysaccharides	54-60	CD4 molecule	Homo sapiens	37-40
28279830-5	2017	Two sera depended on the N463 glycan, again suggesting CD4bs overlap.	Polysaccharides	30-36	CD4 molecule	Homo sapiens	55-58
28452943-8	2017	These findings demonstrated that bee pollen polysaccharide alleviated liver steatosis and insulin resistance by promoting autophagy via an AMPK/mTOR-mediated signaling pathway, suggesting that RBPP-P could be a novel therapeutic agent used for the treatment of obesity and diabetes.	Polysaccharides	44-58	mechanistic target of rapamycin kinase	Mus musculus	144-148
28461410-0	2017	Structural Diversity of Human Gastric Mucin Glycans.	Polysaccharides	44-51	LOC100508689	Homo sapiens	38-43
28445724-2	2017	Here, we use targeted deglycosylation to measure the impact of the glycan shield on elicitation of antibodies against the CD4 supersite.	Polysaccharides	67-73	CD4 molecule	Homo sapiens	122-125
28445724-4	2017	Immunizations yielded little neutralization against wild-type viruses but potent CD4-supersite neutralization (titers 1: &gt;1,000,000 against four-glycan-deleted autologous viruses with over 90% breadth against four-glycan-deleted heterologous strains exhibiting tier 2 neutralization character).	Polysaccharides	148-154	CD4 molecule	Homo sapiens	81-84
28445724-4	2017	Immunizations yielded little neutralization against wild-type viruses but potent CD4-supersite neutralization (titers 1: &gt;1,000,000 against four-glycan-deleted autologous viruses with over 90% breadth against four-glycan-deleted heterologous strains exhibiting tier 2 neutralization character).	Polysaccharides	217-223	CD4 molecule	Homo sapiens	81-84
28425917-5	2017	We reveal that the interaction between TAPBPR and UGT1 facilities the reglucosylation of the glycan on MHC class I molecules, promoting their recognition by calreticulin.	Polysaccharides	93-99	TAP binding protein like	Homo sapiens	39-45
28425917-5	2017	We reveal that the interaction between TAPBPR and UGT1 facilities the reglucosylation of the glycan on MHC class I molecules, promoting their recognition by calreticulin.	Polysaccharides	93-99	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	50-54
28418378-0	2017	Polysaccharide structure: A hint from gut bacteria.	Polysaccharides	0-14	histidine triad nucleotide binding protein 1	Homo sapiens	28-32
28322382-0	2017	Regulation of RAW 264.7 cell-mediated immunity by polysaccharides from Agaricus blazei Murill via the MAPK signal transduction pathway.	Polysaccharides	50-65	mitogen-activated protein kinase 1	Mus musculus	102-106
28422167-5	2017	Incubation of the labelled ligand with oxidized live cells leads to the formation of crosslinks with aldehyde-containing glycans on the cell surface receptor.	Polysaccharides	121-128	CD177 molecule	Homo sapiens	136-157
28404918-3	2017	The lysosomal exoenzyme, alpha-L-fucosidase-1 (FUCA-1) removes fucose residues from glycans.	Polysaccharides	84-91	alpha-L-fucosidase 1	Homo sapiens	25-45
28404918-3	2017	The lysosomal exoenzyme, alpha-L-fucosidase-1 (FUCA-1) removes fucose residues from glycans.	Polysaccharides	84-91	alpha-L-fucosidase 1	Homo sapiens	47-53
28166380-3	2017	To facilitate the implementation of 3D 13 C-edited spectra to deconvolute spectral overlap and to determine the solution structure of Man-9, we developed a robust expression system for the production of 13 C,15 N-labeled glycans in mammalian cells.	Polysaccharides	221-228	mannosidase alpha class 1A member 1	Homo sapiens	134-139
28373556-2	2017	Whereas the majority of Ara found in plant glycans occurs as a furanose ring (Araf), the activated precursor has a pyranose ring configuration (UDP-Arap).	Polysaccharides	43-50	alpha-L-arabinofuranosidase 1	Arabidopsis thaliana	78-82
28161574-4	2017	An engineered interferon-gamma (IFN-gamma) fusion protein was tagged with an N-terminal azide group, and immobilized to two different dibenzocyclooctyne-functionalized biomimetic polysaccharides (chitosan and hyaluronan).	Polysaccharides	179-194	interferon gamma	Rattus norvegicus	14-30
28423342-4	2017	We showed that the long anionic HCDR3 of PGT145 penetrated between glycans at the trimer 3-fold axis, to contact peptide residues from all three Env protomers, and thus explains its highly trimer-specific nature.	Polysaccharides	67-74	endogenous retrovirus group K member 20	Homo sapiens	145-148
28161574-4	2017	An engineered interferon-gamma (IFN-gamma) fusion protein was tagged with an N-terminal azide group, and immobilized to two different dibenzocyclooctyne-functionalized biomimetic polysaccharides (chitosan and hyaluronan).	Polysaccharides	179-194	interferon gamma	Rattus norvegicus	32-41
28414807-8	2017	Since the STn glycan decoration is more frequently found on the surface of carcinomas than the Tn glycan, the binding of MUC1 carrying STn to MGL may be more physiologically relevant and may be in part responsible for some of the characteristics of STn expressing tumours.	Polysaccharides	14-20	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	10-13
28286305-10	2017	Knockdown of YIPF1 and YIPF2, but not that of YIPF6, also reduced intracellular glycans in HT-29 cells.	Polysaccharides	80-87	Yip1 domain family member 2	Homo sapiens	23-28
28414807-8	2017	Since the STn glycan decoration is more frequently found on the surface of carcinomas than the Tn glycan, the binding of MUC1 carrying STn to MGL may be more physiologically relevant and may be in part responsible for some of the characteristics of STn expressing tumours.	Polysaccharides	14-20	mucin 1, cell surface associated	Homo sapiens	121-125
28414807-8	2017	Since the STn glycan decoration is more frequently found on the surface of carcinomas than the Tn glycan, the binding of MUC1 carrying STn to MGL may be more physiologically relevant and may be in part responsible for some of the characteristics of STn expressing tumours.	Polysaccharides	14-20	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	135-138
28414807-8	2017	Since the STn glycan decoration is more frequently found on the surface of carcinomas than the Tn glycan, the binding of MUC1 carrying STn to MGL may be more physiologically relevant and may be in part responsible for some of the characteristics of STn expressing tumours.	Polysaccharides	14-20	C-type lectin domain containing 10A	Homo sapiens	142-145
28414807-8	2017	Since the STn glycan decoration is more frequently found on the surface of carcinomas than the Tn glycan, the binding of MUC1 carrying STn to MGL may be more physiologically relevant and may be in part responsible for some of the characteristics of STn expressing tumours.	Polysaccharides	14-20	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	135-138
28286305-0	2017	YIPF1, YIPF2, and YIPF6 are medial-/trans-Golgi and trans-Golgi network-localized Yip domain family proteins, which play a role in the Golgi reassembly and glycan synthesis.	Polysaccharides	156-162	Yip1 domain family member 1	Homo sapiens	0-5
28286305-0	2017	YIPF1, YIPF2, and YIPF6 are medial-/trans-Golgi and trans-Golgi network-localized Yip domain family proteins, which play a role in the Golgi reassembly and glycan synthesis.	Polysaccharides	156-162	Yip1 domain family member 2	Homo sapiens	7-12
28416578-3	2017	Specifically, we learned that the structures of glycans presented for the PD-L1 peptide were drawn and labeled incorrectly.	Polysaccharides	48-55	CD274 molecule	Homo sapiens	74-79
28286305-11	2017	Thus, we confirmed that YIPF1, YIPF2, and YIPF6 play a significant role in supporting normal glycan synthesis.	Polysaccharides	93-99	Yip1 domain family member 1	Homo sapiens	24-29
28286305-0	2017	YIPF1, YIPF2, and YIPF6 are medial-/trans-Golgi and trans-Golgi network-localized Yip domain family proteins, which play a role in the Golgi reassembly and glycan synthesis.	Polysaccharides	156-162	Yip1 domain family member 6	Homo sapiens	18-23
28286305-11	2017	Thus, we confirmed that YIPF1, YIPF2, and YIPF6 play a significant role in supporting normal glycan synthesis.	Polysaccharides	93-99	Yip1 domain family member 2	Homo sapiens	31-36
28286305-10	2017	Knockdown of YIPF1 and YIPF2, but not that of YIPF6, also reduced intracellular glycans in HT-29 cells.	Polysaccharides	80-87	Yip1 domain family member 1	Homo sapiens	13-18
28286305-11	2017	Thus, we confirmed that YIPF1, YIPF2, and YIPF6 play a significant role in supporting normal glycan synthesis.	Polysaccharides	93-99	Yip1 domain family member 6	Homo sapiens	42-47
28244758-8	2017	Here, we report four proteins (LIFR, CE350, VP13A, HPT) found in sera from pancreatic cancer patients carrying aberrant glycan structures as compared to those of controls.	Polysaccharides	120-126	LIF receptor subunit alpha	Homo sapiens	31-35
27908641-5	2017	Specifically, we built homology models of the three antibody-gp120 complexes, extended the sampling times for large bulky residues, incorporated the modeling of glycans on the surface of gp120, and utilized continuum solvent-based loop prediction protocols to improve sampling.	Polysaccharides	161-168	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	187-192
28202756-1	2017	HIV-1 envelope glycoprotein (Env) glycosylation is important because individual glycans are components of multiple broadly neutralizing antibody epitopes, while shielding other sites that might otherwise be immunogenic.	Polysaccharides	80-87	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	6-27
28202756-1	2017	HIV-1 envelope glycoprotein (Env) glycosylation is important because individual glycans are components of multiple broadly neutralizing antibody epitopes, while shielding other sites that might otherwise be immunogenic.	Polysaccharides	80-87	endogenous retrovirus group K member 20	Homo sapiens	29-32
28202756-6	2017	Over half of the gp120 glycosylation sites on 11 different trimeric Envs have a conserved glycan profile, indicating that a native consensus glycosylation profile does indeed exist among trimers.	Polysaccharides	90-96	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	17-22
28168995-0	2017	Starch-derived absorbable polysaccharide hemostat enhances bone healing via BMP-2 protein.	Polysaccharides	26-40	bone morphogenetic protein 2	Mus musculus	76-81
28952509-11	2017	Multivalent ligand presentation of neo-glycoproteins significantly increased the inhibitory potency towards galectin-3 binding to asialofetuin when compared to free monovalent glycans.	Polysaccharides	176-183	galectin 3	Homo sapiens	108-118
28378791-4	2017	Our simulations predict that intra-domain interactions involving the glycan attached to residue GluN1-N440 stabilize closed-clamshell conformations of the GluN1 LBD.	Polysaccharides	69-75	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	96-101
28378791-4	2017	Our simulations predict that intra-domain interactions involving the glycan attached to residue GluN1-N440 stabilize closed-clamshell conformations of the GluN1 LBD.	Polysaccharides	69-75	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	155-160
28378791-5	2017	The glycan on GluN2B-N688 shows a similar, though weaker, effect.	Polysaccharides	4-10	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	14-20
28378791-6	2017	Based on these results, and assuming the transferability of the results of LBD simulations to the full receptor, we predict that glycans at GluN1-N440 might play a potentiator role in NMDARs.	Polysaccharides	129-136	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	140-145
28287405-2	2017	Carbohydrate conjugate vaccines achieve this by coupling bacterial polysaccharides to a carrier protein that recruits heterologous CD4 T cells to help B cell maturation.	Polysaccharides	67-82	CD4 molecule	Homo sapiens	131-134
27928899-0	2017	Alleviating VLDL overproduction is an important mechanism for Laminaria japonica polysaccharide to inhibit atherosclerosis in LDLr-/- mice with diet-induced insulin resistance.	Polysaccharides	81-95	insulin	Homo sapiens	157-164
27565798-0	2017	A Selenium-Enriched Ziyang Green Tea Polysaccharide Induces Bax-Dependent Mitochondrial Apoptosis and Inhibits TGF-beta1-Stimulated Collagen Expression in Human Keloid Fibroblasts via NG2 Inactivation.	Polysaccharides	37-51	BCL2 associated X, apoptosis regulator	Homo sapiens	60-63
27565798-0	2017	A Selenium-Enriched Ziyang Green Tea Polysaccharide Induces Bax-Dependent Mitochondrial Apoptosis and Inhibits TGF-beta1-Stimulated Collagen Expression in Human Keloid Fibroblasts via NG2 Inactivation.	Polysaccharides	37-51	transforming growth factor beta 1	Homo sapiens	111-120
27975160-6	2017	Increased glycosylation accompanied by alterations in glycosyltranferases, glycosidases, glycans and mucins (MUC)s are also involved in loss of E-cadherin, a key molecule implicated in metastatic dissemination of cells.	Polysaccharides	89-96	cadherin 1	Homo sapiens	144-154
28103508-11	2017	Compared with Model group, The IL-6 concentration and apoptosis rate of aloe polysaccharide group and positive drug group were significantly down-regulation (P&lt;0.05, respectively).	Polysaccharides	77-91	interleukin 6	Rattus norvegicus	31-35
28103508-12	2017	In the gene expression, JAK2 and STAT-3 expression of aloe polysaccharide group and positive drug group were higher than model group (P&lt;0.05, respectively).	Polysaccharides	59-73	signal transducer and activator of transcription 3	Rattus norvegicus	33-39
28103508-13	2017	JAK2, p-JAK2, STAT-3 and p-STAT3 protein expression of Aloe polysaccharide group and positive drug group were lower than model group.	Polysaccharides	60-74	Janus kinase 2	Rattus norvegicus	0-4
28103508-13	2017	JAK2, p-JAK2, STAT-3 and p-STAT3 protein expression of Aloe polysaccharide group and positive drug group were lower than model group.	Polysaccharides	60-74	signal transducer and activator of transcription 3	Rattus norvegicus	27-32
28103508-15	2017	In immuno histochemistry, The JAK2, p-JAK2, STAT-3 and p-STAT3 protein expression of aloe polysaccharide and positive drug group was significantly improved, The JAK2 and STAT-3 gene expression of aloe polysaccharide group and positive drug group were signivicantly lower than those of model group (P&lt;0.05, respectively).	Polysaccharides	90-104	Janus kinase 2	Rattus norvegicus	30-34
28103508-15	2017	In immuno histochemistry, The JAK2, p-JAK2, STAT-3 and p-STAT3 protein expression of aloe polysaccharide and positive drug group was significantly improved, The JAK2 and STAT-3 gene expression of aloe polysaccharide group and positive drug group were signivicantly lower than those of model group (P&lt;0.05, respectively).	Polysaccharides	90-104	Janus kinase 2	Rattus norvegicus	38-42
28103508-15	2017	In immuno histochemistry, The JAK2, p-JAK2, STAT-3 and p-STAT3 protein expression of aloe polysaccharide and positive drug group was significantly improved, The JAK2 and STAT-3 gene expression of aloe polysaccharide group and positive drug group were signivicantly lower than those of model group (P&lt;0.05, respectively).	Polysaccharides	90-104	signal transducer and activator of transcription 3	Rattus norvegicus	44-50
28103508-15	2017	In immuno histochemistry, The JAK2, p-JAK2, STAT-3 and p-STAT3 protein expression of aloe polysaccharide and positive drug group was significantly improved, The JAK2 and STAT-3 gene expression of aloe polysaccharide group and positive drug group were signivicantly lower than those of model group (P&lt;0.05, respectively).	Polysaccharides	90-104	signal transducer and activator of transcription 3	Rattus norvegicus	57-62
28103508-15	2017	In immuno histochemistry, The JAK2, p-JAK2, STAT-3 and p-STAT3 protein expression of aloe polysaccharide and positive drug group was significantly improved, The JAK2 and STAT-3 gene expression of aloe polysaccharide group and positive drug group were signivicantly lower than those of model group (P&lt;0.05, respectively).	Polysaccharides	90-104	Janus kinase 2	Rattus norvegicus	38-42
28103508-15	2017	In immuno histochemistry, The JAK2, p-JAK2, STAT-3 and p-STAT3 protein expression of aloe polysaccharide and positive drug group was significantly improved, The JAK2 and STAT-3 gene expression of aloe polysaccharide group and positive drug group were signivicantly lower than those of model group (P&lt;0.05, respectively).	Polysaccharides	90-104	signal transducer and activator of transcription 3	Rattus norvegicus	170-176
28348411-3	2017	bNAbs to HIV develop during infection, with many showing dependence on glycans for binding to Env.	Polysaccharides	71-78	endogenous retrovirus group K member 20	Homo sapiens	94-97
28362263-6	2017	In cells and mice, it blocked ppGalNAc-T3-mediated glycan-masking of FGF23 thereby increasing its cleavage, a possible treatment of chronic kidney disease.	Polysaccharides	51-57	fibroblast growth factor 23	Mus musculus	69-74
28361971-1	2017	PG2 is an infusible polysaccharide extracted from Astragalus membranaceus, which is a Chinese herb traditionally used for stroke treatment.	Polysaccharides	20-34	delta like non-canonical Notch ligand 1	Homo sapiens	0-3
28348411-7	2017	We find that most glycosites in recombinant Env trimers are fully occupied by glycans, varying in the proportion of high-mannose/hybrid and complex-type glycans.	Polysaccharides	78-85	endogenous retrovirus group K member 20	Homo sapiens	44-47
28405145-0	2017	Acanthopanax senticosus polysaccharides-induced intestinal tight junction injury alleviation via inhibition of NF-kappaB/MLCK pathway in a mouse endotoxemia model.	Polysaccharides	24-39	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	111-120
28348411-7	2017	We find that most glycosites in recombinant Env trimers are fully occupied by glycans, varying in the proportion of high-mannose/hybrid and complex-type glycans.	Polysaccharides	153-160	endogenous retrovirus group K member 20	Homo sapiens	44-47
28199092-7	2017	Our results demonstrate that MAM quantification of individual glycan species from both the Fab and Fc N-Linked glycosylation sites is consistent with quantification using the traditional hydrophilic interaction liquid chromatography (HILIC) analysis of enzymatically released and fluorescently labeled glycans.	Polysaccharides	62-68	FA complementation group B	Homo sapiens	91-94
28405145-0	2017	Acanthopanax senticosus polysaccharides-induced intestinal tight junction injury alleviation via inhibition of NF-kappaB/MLCK pathway in a mouse endotoxemia model.	Polysaccharides	24-39	myosin light chain kinase 3	Mus musculus	121-125
28396675-0	2017	Inactivation of the beta(1,2)-xylosyltransferase and the alpha(1,3)-fucosyltransferase genes in Nicotiana tabacum BY-2 Cells by a Multiplex CRISPR/Cas9 Strategy Results in Glycoproteins without Plant-Specific Glycans.	Polysaccharides	209-216	beta-(1,2)-xylosyltransferase-like	Nicotiana tabacum	20-48
28396675-0	2017	Inactivation of the beta(1,2)-xylosyltransferase and the alpha(1,3)-fucosyltransferase genes in Nicotiana tabacum BY-2 Cells by a Multiplex CRISPR/Cas9 Strategy Results in Glycoproteins without Plant-Specific Glycans.	Polysaccharides	209-216	glycoprotein 3-alpha-L-fucosyltransferase A-like	Nicotiana tabacum	57-86
28396675-3	2017	Two enzymes are responsible for the addition of plant-specific glycans: beta(1,2)-xylosyltransferase (XylT) and alpha(1,3)-fucosyltransferase (FucT).	Polysaccharides	63-70	beta-(1,2)-xylosyltransferase-like	Nicotiana tabacum	72-100
28396675-3	2017	Two enzymes are responsible for the addition of plant-specific glycans: beta(1,2)-xylosyltransferase (XylT) and alpha(1,3)-fucosyltransferase (FucT).	Polysaccharides	63-70	beta-(1,2)-xylosyltransferase-like	Nicotiana tabacum	102-106
28396675-3	2017	Two enzymes are responsible for the addition of plant-specific glycans: beta(1,2)-xylosyltransferase (XylT) and alpha(1,3)-fucosyltransferase (FucT).	Polysaccharides	63-70	glycoprotein 3-alpha-L-fucosyltransferase A-like	Nicotiana tabacum	112-141
28396675-3	2017	Two enzymes are responsible for the addition of plant-specific glycans: beta(1,2)-xylosyltransferase (XylT) and alpha(1,3)-fucosyltransferase (FucT).	Polysaccharides	63-70	glycoprotein 3-alpha-L-fucosyltransferase A-like	Nicotiana tabacum	143-147
28327518-5	2017	To block CLR interactions with viral glycoproteins, antiviral strategies may involve the use of multivalent glycan carrier systems.	Polysaccharides	108-114	doublecortin like kinase 3	Homo sapiens	9-12
28287093-6	2017	HDL that increased IL-6 secretion were enriched in ApoC-III, di-sialylated glycans at multiple A1AT glycosylation sites and desialylated A2HSG, and depleted in mono-sialylated ApoC-III (ApoC-III1).	Polysaccharides	75-82	interleukin 6	Homo sapiens	19-23
28303957-0	2017	Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo.	Polysaccharides	11-26	toll-like receptor 4	Mus musculus	63-67
28303957-0	2017	Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo.	Polysaccharides	11-26	myeloid differentiation primary response gene 88	Mus musculus	77-82
28303970-9	2017	The decrease in the strong electronegative charge of terminal glycans may modulate hemostatic protein-protein interactions, which in combination with a strong prothrombotic situation, such as antithrombin deficiency, could increase the risk of thrombosis.	Polysaccharides	62-69	serpin family C member 1	Homo sapiens	192-204
28177462-2	2017	BC2LCN is specific for glycans with a terminal Fucalpha1,2Galbeta1,3-motif and it is a useful marker for discriminating the undifferentiated status of human induced/embryonic stem cells.	Polysaccharides	23-30	charged multivesicular body protein 2A	Homo sapiens	0-3
28289177-0	2017	Structural diversity of human gastric mucin glycans.	Polysaccharides	44-51	LOC100508689	Homo sapiens	38-43
28297651-4	2017	Here, we used surface plasmon resonance (SPR) and NMR spectroscopy to characterize the interaction between two tau fragments, K18 and K19, and several polysaccharides, including heparin, heparin oligosaccharides, chemically modified heparin, and related glycans.	Polysaccharides	151-166	keratin 18	Homo sapiens	126-129
28297651-4	2017	Here, we used surface plasmon resonance (SPR) and NMR spectroscopy to characterize the interaction between two tau fragments, K18 and K19, and several polysaccharides, including heparin, heparin oligosaccharides, chemically modified heparin, and related glycans.	Polysaccharides	151-166	keratin 19	Homo sapiens	134-137
28287093-6	2017	HDL that increased IL-6 secretion were enriched in ApoC-III, di-sialylated glycans at multiple A1AT glycosylation sites and desialylated A2HSG, and depleted in mono-sialylated ApoC-III (ApoC-III1).	Polysaccharides	75-82	serpin family A member 1	Homo sapiens	95-99
28282887-2	2017	While inhibition of the factor Xa is well described, little is known about the polysaccharide structure inhibiting thrombin.	Polysaccharides	79-93	coagulation factor II, thrombin	Homo sapiens	115-123
28278283-4	2017	Here, we developed capsular polysaccharide conjugates by linking mycobacterial capsular arabinomannan (AM) to either Mtb Ag85b or B. anthracis protective antigen (PA).	Polysaccharides	28-42	non-SMC condensin II complex, subunit G2	Mus musculus	117-120
28316571-0	2017	Anti-Cancerous Potential of Polysaccharide Fractions Extracted from Peony Seed Dreg on Various Human Cancer Cell Lines Via Cell Cycle Arrest and Apoptosis.	Polysaccharides	28-42	adhesion G protein-coupled receptor G6	Homo sapiens	79-83
29108390-4	2017	Truncated-O-glycan score was built by integrating the expression level of Tn-, sTn- and sT-antigen.	Polysaccharides	12-18	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	79-82
28316571-1	2017	In this study, four homo/heterogenous polysaccharides (HBSS, CHSS, DASS, and CASS) extracted from peony seed dreg with respective molecular weights of 3467, 4677, 229, and 56 kDa were evaluated for anti-cancerous attributes in prostate cancer cells (Pc-3), colon cancer cells (HCT-116), human breast cancer cells (MCF-7), cervical cancer (Hela cells) and human embryonic kidney 293 (HEK 293) cells as control.	Polysaccharides	38-53	adhesion G protein-coupled receptor G6	Homo sapiens	109-113
28027502-5	2017	Curdlan and mannan were used as bioactive polysaccharides because they are known to activate DCs via their respective interactions with Dectin-1 and Dectin-2.	Polysaccharides	42-57	C-type lectin domain containing 6A	Homo sapiens	149-157
27617577-3	2017	In the present study, we demonstrate that a polysaccharide, RN1, purified from the flower of Panax notoginseng binds to Gal-3 and suppresses its expression.	Polysaccharides	44-58	galectin 3	Homo sapiens	120-125
27965112-2	2017	It was shown that a part of Scw4, previously identified among the non-covalently bound cell wall proteins, was covalently attached to wall polysaccharides by a so far unknown alkali sensitive linkage.	Polysaccharides	139-154	putative family 17 glucosidase	Saccharomyces cerevisiae S288C	28-32
28027502-5	2017	Curdlan and mannan were used as bioactive polysaccharides because they are known to activate DCs via their respective interactions with Dectin-1 and Dectin-2.	Polysaccharides	42-57	C-type lectin domain containing 7A	Homo sapiens	136-144
28027502-6	2017	Carboxylated curdlan and mannan promoted Th1 cytokine production from DCs, indicating the activation of DCs by these polysaccharide derivatives.	Polysaccharides	117-131	negative elongation factor complex member C/D	Homo sapiens	41-44
28031420-0	2017	Novel Protein Glycan-Derived Markers of Systemic Inflammation and C-Reactive Protein in Relation to Glycemia, Insulin Resistance, and Insulin Secretion.	Polysaccharides	14-20	C-reactive protein	Homo sapiens	66-84
27666939-4	2017	A commonly used and efficient approach has been knocking out the FUT8 gene of the Chinese hamster ovary (CHO) host cells, which results in expression of antibody molecules with fully afucosylated glycans.	Polysaccharides	196-203	alpha-(1,6)-fucosyltransferase	Cricetulus griseus	65-69
27984825-0	2017	Colloid, adhesive and release properties of nanoparticular ternary complexes between cationic and anionic polysaccharides and basic proteins like bone morphogenetic protein BMP-2.	Polysaccharides	106-121	bone morphogenetic protein 2	Homo sapiens	173-178
28031420-0	2017	Novel Protein Glycan-Derived Markers of Systemic Inflammation and C-Reactive Protein in Relation to Glycemia, Insulin Resistance, and Insulin Secretion.	Polysaccharides	14-20	insulin	Homo sapiens	110-117
28031420-0	2017	Novel Protein Glycan-Derived Markers of Systemic Inflammation and C-Reactive Protein in Relation to Glycemia, Insulin Resistance, and Insulin Secretion.	Polysaccharides	14-20	insulin	Homo sapiens	134-141
28758107-5	2017	Among the approximately 400 compounds produced by Ganoderma spp., triterpenes, peptidoglycans and polysaccharides are the major physiologically-active constituents.	Polysaccharides	98-113	histocompatibility minor 13	Homo sapiens	60-63
28159857-3	2017	These 8 enzymes are under direct control of the androgen receptor (AR) and are linked to the synthesis of important cancer-associated glycans such as sialyl-Tn (sTn), sialyl LewisX (SLeX), O-GlcNAc and chondroitin sulfate.	Polysaccharides	134-141	androgen receptor	Homo sapiens	48-65
28159857-3	2017	These 8 enzymes are under direct control of the androgen receptor (AR) and are linked to the synthesis of important cancer-associated glycans such as sialyl-Tn (sTn), sialyl LewisX (SLeX), O-GlcNAc and chondroitin sulfate.	Polysaccharides	134-141	androgen receptor	Homo sapiens	67-69
28159857-3	2017	These 8 enzymes are under direct control of the androgen receptor (AR) and are linked to the synthesis of important cancer-associated glycans such as sialyl-Tn (sTn), sialyl LewisX (SLeX), O-GlcNAc and chondroitin sulfate.	Polysaccharides	134-141	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	189-197
28145111-1	2017	The health-promoting effects of milk fat globule membrane (MFGM) glycoconjugates has attracted curiosity especially with regard to the challenges encountered to unravel the glycan complexities of MFGM glycoproteins and glycosphingolipids.	Polysaccharides	173-179	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	59-63
28145111-1	2017	The health-promoting effects of milk fat globule membrane (MFGM) glycoconjugates has attracted curiosity especially with regard to the challenges encountered to unravel the glycan complexities of MFGM glycoproteins and glycosphingolipids.	Polysaccharides	173-179	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	196-200
27874253-4	2017	This article reports a polysaccharide-based tissue engineered periosteum that delivers basic fibroblast growth factor (FGF-2), transforming growth factor-beta1 (TGF-beta1), and adipose-derived mesenchymal stem cells (ASCs) to a critical-sized mouse femur defect.	Polysaccharides	23-37	fibroblast growth factor 2	Mus musculus	87-117
27874253-4	2017	This article reports a polysaccharide-based tissue engineered periosteum that delivers basic fibroblast growth factor (FGF-2), transforming growth factor-beta1 (TGF-beta1), and adipose-derived mesenchymal stem cells (ASCs) to a critical-sized mouse femur defect.	Polysaccharides	23-37	fibroblast growth factor 2	Mus musculus	119-124
27874253-4	2017	This article reports a polysaccharide-based tissue engineered periosteum that delivers basic fibroblast growth factor (FGF-2), transforming growth factor-beta1 (TGF-beta1), and adipose-derived mesenchymal stem cells (ASCs) to a critical-sized mouse femur defect.	Polysaccharides	23-37	transforming growth factor, beta 1	Mus musculus	127-159
27874253-4	2017	This article reports a polysaccharide-based tissue engineered periosteum that delivers basic fibroblast growth factor (FGF-2), transforming growth factor-beta1 (TGF-beta1), and adipose-derived mesenchymal stem cells (ASCs) to a critical-sized mouse femur defect.	Polysaccharides	23-37	transforming growth factor, beta 1	Mus musculus	161-170
27888523-7	2017	The galactose: arabinose ratio of AG glycans was higher in GhGalT1 overexpression fibers, but was lower in GhGalT1-silenced lines, compared with that in the wild type.	Polysaccharides	37-44	probable beta-1,3-galactosyltransferase 14	Gossypium hirsutum	59-66
27888523-9	2017	An enzyme activity assay demonstrated that GhGalT1 is a beta-1,3-galactosyltransferase (beta-1,3-GalT) involved in biosynthesis of the beta-1,3-galactan backbone of the type-II AG glycans of AGPs.	Polysaccharides	180-187	probable beta-1,3-galactosyltransferase 14	Gossypium hirsutum	43-50
27888523-10	2017	We also show that GhGalT1 can form homo- and heterodimers with other cotton GT31 family members to facilitate AG glycan assembly of AGPs.	Polysaccharides	113-119	probable beta-1,3-galactosyltransferase 14	Gossypium hirsutum	18-25
28249163-2	2017	A bnAb target is the Env third variable loop (V3)-glycan site.	Polysaccharides	50-56	endogenous retrovirus group K member 20	Homo sapiens	21-24
28280387-7	2017	The immunohistochemical sections depicted that the treatment of DMBA-administered rats with ulvan polysaccharides markedly increased the lowered pro-apoptotic protein, p53, and decreased the elevated anti-apoptotic marker, bcl2, expression in the breast tissue.	Polysaccharides	98-113	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	168-171
28280387-7	2017	The immunohistochemical sections depicted that the treatment of DMBA-administered rats with ulvan polysaccharides markedly increased the lowered pro-apoptotic protein, p53, and decreased the elevated anti-apoptotic marker, bcl2, expression in the breast tissue.	Polysaccharides	98-113	BCL2, apoptosis regulator	Rattus norvegicus	223-227
28280387-9	2017	The elevated levels of inflammatory cytokines tumor necrosis factor-alpha and nitric oxide were significantly ameliorated in DMBA-administered rats treated with ulvan polysaccharides as compared to DMBA-administered control.	Polysaccharides	167-182	tumor necrosis factor	Rattus norvegicus	46-73
28230186-0	2017	Glycan-independent binding and internalization of human IgM to FCMR, its cognate cellular receptor.	Polysaccharides	0-6	Fc mu receptor	Homo sapiens	63-67
28230186-5	2017	In this study, we identify the Cmu4 domain of IgM as the target of hFCMR, and show that binding and internalization of IgM by hFCMR is glycan-independent.	Polysaccharides	135-141	Fc mu receptor	Homo sapiens	126-131
28053085-5	2017	It is likely that YKL-40 is interacting with these alternative polysaccharides or proteins within the body, extending its function to cell biological roles such as mediating cellular receptors and cell adhesion and migration.	Polysaccharides	63-78	chitinase 3 like 1	Homo sapiens	18-24
28345463-6	2017	The use of bioinformatics tool revealed better binding affinity for the drug-polysaccharide complex than the drug alone with three proteins: 3QX3 (Topoisomerase), 1M17 (EGFR tyrosine kinase domain), and 3QRJ (ABL1 kinase domain).	Polysaccharides	77-91	epidermal growth factor receptor	Homo sapiens	169-173
27984693-1	2017	A vital step in HIV vaccine development strategies has been the observation that some infected individuals generate broadly neutralizing antibodies that target the glycans on the surface of HIV-1 gp120.	Polysaccharides	164-171	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	196-201
27984693-5	2017	Here, we trap the glycan processing of recombinant gp120 to generate homogeneous glycoforms, facilitating occupancy assessment by intact mass spectrometry.	Polysaccharides	18-24	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	51-56
27984693-6	2017	We show that gp120 monomers of the BG505 strain contain either fully occupied sequons or missing the equivalent of one and sometimes two glycans across the molecule.	Polysaccharides	137-144	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	13-18
30108811-1	2017	Carboxymethylated and sulfated polysaccharides (CLEP and SLEP) were prepared from an exopolysaccharide previously obtained from Lachnum YM240 (LEP) by chemical modifications.	Polysaccharides	31-46	leptin	Mus musculus	49-52
27987946-0	2017	Lactoferrin-coated polysaccharide nanoparticles based on chitosan hydrochloride/hyaluronic acid/PEG for treating brain glioma.	Polysaccharides	19-33	lactotransferrin	Mus musculus	0-11
28117590-1	2017	In our previous study, three novel polysaccharides, named MC-1, MC-2, and MC-3, were separated from the roots of maca (Lepidium meyenii), which is a food source from the Andes region.	Polysaccharides	35-50	melanocortin 5 receptor	Homo sapiens	64-68
28207759-4	2017	Two recombinant GBA preparations with distinct N-linked glycans are registered in Europe for treatment of type I GD: imiglucerase (Genzyme), contains predominantly Man(3) glycans, and velaglucerase (Shire PLC) Man(9) glycans.	Polysaccharides	56-63	glucosylceramidase beta	Homo sapiens	16-19
28207759-4	2017	Two recombinant GBA preparations with distinct N-linked glycans are registered in Europe for treatment of type I GD: imiglucerase (Genzyme), contains predominantly Man(3) glycans, and velaglucerase (Shire PLC) Man(9) glycans.	Polysaccharides	171-178	glucosylceramidase beta	Homo sapiens	16-19
30108800-8	2017	Non-nucleotide-derived NPP1 inhibitors comprise polysulfonates, polysaccharides, polyoxometalates and small heterocyclic compounds.	Polysaccharides	64-79	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	23-27
28031460-10	2017	Our findings suggest that ST6GAL1 has an inhibitory role in adipogenesis through integrin-beta1 activation, providing new insights into the roles and regulation mechanisms of glycans in adipocytes during obesity.	Polysaccharides	175-182	beta galactoside alpha 2,6 sialyltransferase 1	Mus musculus	26-33
28031460-10	2017	Our findings suggest that ST6GAL1 has an inhibitory role in adipogenesis through integrin-beta1 activation, providing new insights into the roles and regulation mechanisms of glycans in adipocytes during obesity.	Polysaccharides	175-182	integrin beta 1 (fibronectin receptor beta)	Mus musculus	81-95
28170415-2	2017	Glycans attached through N-glycosidic bonds may contribute to Lactoferrin functional activities.	Polysaccharides	0-7	lactotransferrin	Bos taurus	62-73
27966990-5	2017	The objectives of the present study were to characterize N-glycosylation sites in VEGFR-2 via enzymatic release of the glycans and concomitant incorporation of 18O into formerly N-glycosylated sites followed by tandem mass spectrometry (MS/MS) analysis to determine N-glycosylation site occupancy and the site-specific N-glycan heterogeneity of VEGFR-2 glycopeptides.	Polysaccharides	119-126	kinase insert domain receptor	Homo sapiens	82-89
28150729-0	2017	Short stop mediates axonal compartmentalization of mucin-type core 1 glycans.	Polysaccharides	69-76	short stop	Drosophila melanogaster	0-10
28157181-6	2017	Our data reveal that mu  lacking 563 glycans (mu 5) form larger intracellular aggregates than mu  and are not secreted.	Polysaccharides	37-44	adaptor related protein complex 5 subunit mu 1	Homo sapiens	46-50
28157181-8	2017	In contrast, mu  lacking 402 glycans (mu 4) remain detergent soluble and accumulate in the ER, as does a double mutant devoid of both (mu 4-5).	Polysaccharides	29-36	adaptor related protein complex 4 subunit mu 1	Homo sapiens	38-42
27476720-1	2017	The aim of this study was to determine the allele frequency of the glycogen synthase 1 (GYS1) mutation associated with polysaccharide storage myopathy type 1 in the Austrian Noriker horse.	Polysaccharides	119-133	glycogen synthase 1	Equus caballus	67-86
27476720-1	2017	The aim of this study was to determine the allele frequency of the glycogen synthase 1 (GYS1) mutation associated with polysaccharide storage myopathy type 1 in the Austrian Noriker horse.	Polysaccharides	119-133	glycogen synthase 1	Equus caballus	88-92
27943633-7	2017	Finally, glycoprofiling of IgG with four amino acid substitutions expressed from an alpha-2,3 sialyltransferase knockout-alpha-2,6 sialyltransferase stable clone resulted in more than 77% sialylated glycans and more than 62% biantennary disialylated glycans as indicated by both MALDI-TOF and LC-ESI-MS.	Polysaccharides	199-206	beta-galactoside alpha-2,6-sialyltransferase 1	Cricetulus griseus	121-148
28198663-1	2017	Shortly after a surface is submerged in the sea, a conditioning film is generally formed by adsorption of organic molecules, such as polysaccharides.	Polysaccharides	133-148	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	44-47
27943633-7	2017	Finally, glycoprofiling of IgG with four amino acid substitutions expressed from an alpha-2,3 sialyltransferase knockout-alpha-2,6 sialyltransferase stable clone resulted in more than 77% sialylated glycans and more than 62% biantennary disialylated glycans as indicated by both MALDI-TOF and LC-ESI-MS.	Polysaccharides	250-257	beta-galactoside alpha-2,6-sialyltransferase 1	Cricetulus griseus	121-148
27999993-3	2017	Among others, glycan-related proteins as sialidase Neu3 or galectins-1, -3, and -4 play central roles in the determination of axonal fate, axon growth, guidance and regeneration, as well as in polarized axonal glycoprotein transport.	Polysaccharides	14-20	galectin 1	Homo sapiens	41-82
27999995-9	2017	With respect to infections, various GSL-presented glycans are attachment sites for bacteria and viruses as well as primary targets for bacterial toxins.	Polysaccharides	50-57	cathepsin A	Homo sapiens	36-39
27979781-2	2017	It also functions as an activating ligand of the vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2), and binds strongly to the sulfated polysaccharide, heparin.	Polysaccharides	147-161	kinase insert domain protein receptor	Mus musculus	103-109
27807897-5	2017	In cultured macrophages (RAW 264.7 cells), the application of polysaccharide-enriched extract of DBT significantly increased the expressions of mRNA and protein levels of interleukin-1beta, interleukin-6 and tumor necrosis factor.	Polysaccharides	62-76	interleukin 1 beta	Mus musculus	171-188
27634372-1	2017	A DOX-loaded polysaccharide-lecithin reverse micelles triglyceride-based oral delivery nanocarrier (D-PL/TG NPs) conjugated with (i) RGD peptide for targeting to beta1 integrin of M cells and (ii) Lyp-1 peptide for targeting to the p32 receptor of MDA-MB-231 cells is used to investigate the multistage continuous targeting capabilities of these peptide-conjugated nanocarriers (GLD-PL/TG NPs) for tumor therapy.	Polysaccharides	13-27	integrin subunit beta 1	Homo sapiens	162-176
27634372-1	2017	A DOX-loaded polysaccharide-lecithin reverse micelles triglyceride-based oral delivery nanocarrier (D-PL/TG NPs) conjugated with (i) RGD peptide for targeting to beta1 integrin of M cells and (ii) Lyp-1 peptide for targeting to the p32 receptor of MDA-MB-231 cells is used to investigate the multistage continuous targeting capabilities of these peptide-conjugated nanocarriers (GLD-PL/TG NPs) for tumor therapy.	Polysaccharides	13-27	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	197-202
27634372-1	2017	A DOX-loaded polysaccharide-lecithin reverse micelles triglyceride-based oral delivery nanocarrier (D-PL/TG NPs) conjugated with (i) RGD peptide for targeting to beta1 integrin of M cells and (ii) Lyp-1 peptide for targeting to the p32 receptor of MDA-MB-231 cells is used to investigate the multistage continuous targeting capabilities of these peptide-conjugated nanocarriers (GLD-PL/TG NPs) for tumor therapy.	Polysaccharides	13-27	inhibitor of growth family member 2	Homo sapiens	232-235
27956708-0	2017	Structural Analysis of Variable Domain Glycosylation of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Reveals the Presence of Highly Sialylated Glycans.	Polysaccharides	160-167	proteinase 3	Homo sapiens	56-93
27956708-6	2017	The structural analyses revealed that ACPA-IgG molecules contain highly sialylated glycans in their Fab-domain.	Polysaccharides	83-90	proteinase 3	Homo sapiens	38-42
27956708-6	2017	The structural analyses revealed that ACPA-IgG molecules contain highly sialylated glycans in their Fab-domain.	Polysaccharides	83-90	FA complementation group B	Homo sapiens	100-103
27807897-5	2017	In cultured macrophages (RAW 264.7 cells), the application of polysaccharide-enriched extract of DBT significantly increased the expressions of mRNA and protein levels of interleukin-1beta, interleukin-6 and tumor necrosis factor.	Polysaccharides	62-76	interleukin 6	Mus musculus	190-203
30650272-20	2017	01) , expressions levels of Bax, Caspase-3, and pAPP were down-regulated, Bcl-2/Bax ratio was obviously elevated in the saponin group, the volatile oil group, the polysaccharide group (P <0.	Polysaccharides	163-177	BCL2, apoptosis regulator	Rattus norvegicus	74-79
27869543-5	2017	These results suggest that mTG preparations may be broadly employed to bond various types of organic materials, including polysaccharides, proteins, and functionalized inorganic polymers to living tissues, which may open new avenues for biomedical engineering, medical device integration, and tissue repair.	Polysaccharides	122-137	protease, serine 3	Mus musculus	27-30
30650272-20	2017	01) , expressions levels of Bax, Caspase-3, and pAPP were down-regulated, Bcl-2/Bax ratio was obviously elevated in the saponin group, the volatile oil group, the polysaccharide group (P <0.	Polysaccharides	163-177	BCL2 associated X, apoptosis regulator	Rattus norvegicus	80-83
30650272-23	2017	Conclusion Three active ingredients (spaonins, benzene, and polysaccharides) of QKR could improve spatial memory and learning capacities to different degrees, which might be possibly achieved by decreasing expressions of Bax, Caspase-3, PAPP in hippocampal CA1 region, elevating Bcl-2 expression, and inhibiting apoptosis in hippocampus.	Polysaccharides	60-75	BCL2 associated X, apoptosis regulator	Rattus norvegicus	221-224
30650272-23	2017	Conclusion Three active ingredients (spaonins, benzene, and polysaccharides) of QKR could improve spatial memory and learning capacities to different degrees, which might be possibly achieved by decreasing expressions of Bax, Caspase-3, PAPP in hippocampal CA1 region, elevating Bcl-2 expression, and inhibiting apoptosis in hippocampus.	Polysaccharides	60-75	BCL2, apoptosis regulator	Rattus norvegicus	279-284
28124680-0	2017	Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax/Bcl-2 Ratio and Caspases.	Polysaccharides	38-53	BCL2 associated X, apoptosis regulator	Homo sapiens	139-142
28722428-0	2017	BSA-Sugar Conjugates as Ideal Building Blocks for SPR-Based Glycan Biosensors.	Polysaccharides	60-66	sepiapterin reductase	Homo sapiens	50-53
28722428-3	2017	The conjugates can absorb directly on gold substrate without any derivation reactions, thus providing a simple and effective method for the construction of SPR-based glycan biosensors.	Polysaccharides	166-172	sepiapterin reductase	Homo sapiens	156-159
28124680-0	2017	Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax/Bcl-2 Ratio and Caspases.	Polysaccharides	38-53	BCL2 apoptosis regulator	Homo sapiens	143-148
28134773-0	2017	Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer.	Polysaccharides	48-54	kallikrein related peptidase 3	Homo sapiens	64-89
28124680-0	2017	Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax/Bcl-2 Ratio and Caspases.	Polysaccharides	38-53	caspase 9	Homo sapiens	159-167
28125599-4	2017	HepG2 cells expressing NTCP with a single glycan supported HBV infection at a comparable level to NTCP-WT.	Polysaccharides	42-48	solute carrier family 10 member 1	Homo sapiens	23-27
28125599-3	2017	NTCP contains two N-linked glycosylation sites and asparagine amino acid residues N5 and N11 were mutated to a glutamine to generate NTCP with a single glycan (NTCP-N5Q or NTCP- N11Q) or no glycans (NTCP- N5,11Q).	Polysaccharides	152-158	solute carrier family 10 member 1	Homo sapiens	0-4
27902927-8	2017	The structure of polysaccharide F31 was obtained from GPC, FTIR NMR and GC-MS spectroscopy, RESULTS: F31 significantly decreased FSG (P&lt;0.05), FSI and epididymal fat/BW ratio (P&lt;0.01).	Polysaccharides	17-31	mitogen-activated protein kinase kinase 3, opposite strand	Mus musculus	32-35
28125599-3	2017	NTCP contains two N-linked glycosylation sites and asparagine amino acid residues N5 and N11 were mutated to a glutamine to generate NTCP with a single glycan (NTCP-N5Q or NTCP- N11Q) or no glycans (NTCP- N5,11Q).	Polysaccharides	190-197	solute carrier family 10 member 1	Homo sapiens	0-4
27842819-2	2017	In the current study, we evaluated the anti-adhesive mechanisms of a water-soluble polysaccharide (BCP) extracted from Bupleurum chinense.	Polysaccharides	83-97	opsin 1, short wave sensitive	Homo sapiens	99-102
28052202-5	2017	In vivo antitumor evaluation showed selenylation polysaccharide could effectively inhibit tumor growth (&gt;50%) and adjust immune factor levels in the mice (IL-2, TNF-alpha, and VEGF).	Polysaccharides	49-63	interleukin 2	Mus musculus	158-162
28052202-5	2017	In vivo antitumor evaluation showed selenylation polysaccharide could effectively inhibit tumor growth (&gt;50%) and adjust immune factor levels in the mice (IL-2, TNF-alpha, and VEGF).	Polysaccharides	49-63	tumor necrosis factor	Mus musculus	164-173
28052202-5	2017	In vivo antitumor evaluation showed selenylation polysaccharide could effectively inhibit tumor growth (&gt;50%) and adjust immune factor levels in the mice (IL-2, TNF-alpha, and VEGF).	Polysaccharides	49-63	vascular endothelial growth factor A	Mus musculus	179-183
28069944-5	2017	We identify alpha2-3-sialyllactose present in the glycan of monosialogangliosides as targets of soluble klotho.	Polysaccharides	50-56	klotho	Mus musculus	104-110
27902927-8	2017	The structure of polysaccharide F31 was obtained from GPC, FTIR NMR and GC-MS spectroscopy, RESULTS: F31 significantly decreased FSG (P&lt;0.05), FSI and epididymal fat/BW ratio (P&lt;0.01).	Polysaccharides	17-31	mitogen-activated protein kinase kinase 3, opposite strand	Mus musculus	101-104
27903635-0	2017	Bacterial Polysaccharide Specificity of the Pattern Recognition Receptor Langerin Is Highly Species-dependent.	Polysaccharides	10-24	CD207 antigen	Mus musculus	73-81
28044410-1	2017	Salecan is a water-soluble bacterial polysaccharide consisting of glucopyranosyl units linked by alpha-1,3 and beta-1,3 glycosidic bonds.	Polysaccharides	37-51	adrenoceptor alpha 1D	Homo sapiens	97-106
28044410-1	2017	Salecan is a water-soluble bacterial polysaccharide consisting of glucopyranosyl units linked by alpha-1,3 and beta-1,3 glycosidic bonds.	Polysaccharides	37-51	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	111-119
28091546-5	2017	We show that several pathways for targeting O-mucin glycans are activated in B. thetaiotaomicron by GOS, as well as the galactan utilization sytem.	Polysaccharides	52-59	LOC100508689	Homo sapiens	46-51
28091546-6	2017	Characterization of the endo-galactanase from this system identified activity on various longer GOS substrates while a subset of GOS compounds were identified as potential activators of mucin glycan metabolism in B. thetaiotaomicron.	Polysaccharides	192-198	LOC100508689	Homo sapiens	186-191
28091546-7	2017	Our results show that GOS functions as an inducer of mucin-glycan pathways while providing a nutrient source in the form of beta-(1   4)-galactan.	Polysaccharides	59-65	LOC100508689	Homo sapiens	53-58
28060820-5	2017	Proteolysis of an IL-6R completely devoid of glycans is significantly impaired.	Polysaccharides	45-52	interleukin 6 receptor	Homo sapiens	18-23
28076349-7	2017	We present results indicating that Obst-E regulates the arrangement of chitin, a long-chain polysaccharide and a central component of the insect cuticle, and directs the formation of supracellular ridges on the larval cuticle.	Polysaccharides	92-106	obstructor-E	Drosophila melanogaster	35-41
27351377-6	2017	Furthermore, using flow cytometry and antibodies directed against glycan structures, we confirmed that the alteration of glycosylation occurs at the cell surface of THP-1 macrophage-like cells.	Polysaccharides	66-72	GLI family zinc finger 2	Homo sapiens	165-170
27873468-0	2017	Synthetic Mucin-Like Glycopeptides as Versatile Tools to Measure Effects of Glycan Structure/Density/Position on the Interaction with Adhesion/Growth-Regulatory Galectins in Arrays.	Polysaccharides	76-82	LOC100508689	Homo sapiens	10-15
27846415-4	2017	Changes in sensitivity to broadly neutralizing monoclonal antibodies suggest that the interaction between glycan 301 and the CD4 binding site differ substantially between these 2 viruses.	Polysaccharides	106-112	CD4 molecule	Homo sapiens	125-128
27999837-2	2017	After crosslinking the natural polysaccharide hyaluronan, a ligand for CD44, cisplatin could be removed by simple dialysis in a salt solution while the withheld drug remains entrapped.	Polysaccharides	31-45	CD44 molecule (Indian blood group)	Homo sapiens	71-75
27941542-3	2017	In patients with this disease, altered glycan structures in the unique hinge region of the heavy chains of IgA1 molecules lead to the exposure of antigenic determinants, which are recognized by naturally occurring antiglycan antibodies of the IgG and/or IgA1 isotype.	Polysaccharides	39-45	immunoglobulin heavy constant alpha 1	Homo sapiens	107-111
27918140-3	2017	Binding to the polysaccharide heparin was found to induce the unfolding of preformed structural elements in OPN.	Polysaccharides	15-29	secreted phosphoprotein 1	Homo sapiens	108-111
27941542-3	2017	In patients with this disease, altered glycan structures in the unique hinge region of the heavy chains of IgA1 molecules lead to the exposure of antigenic determinants, which are recognized by naturally occurring antiglycan antibodies of the IgG and/or IgA1 isotype.	Polysaccharides	39-45	immunoglobulin heavy constant alpha 1	Homo sapiens	254-258
27717713-7	2017	Advanced mass spectrometry led to detailed identification of the glycan structures carried by VWF.	Polysaccharides	65-71	von Willebrand factor	Homo sapiens	94-97
27796453-8	2017	Separation by porous graphitic carbon liquid chromatography at high temperatures in conjunction with tandem mass spectrometry (PGC-LC-MS/MS) was utilized for unequivocal characterization of glycan isomers.	Polysaccharides	190-196	progastricsin	Homo sapiens	127-130
27796453-9	2017	Glycan fucosylation sites were confidently determined by eliminating fucose rearrangement and assignment of diagnostic ions, achieved by permethylation and PGC-LC at high temperatures, respectively.	Polysaccharides	0-6	progastricsin	Homo sapiens	156-159
29130039-4	2017	We found that essential parameters of cospecies biofilm maintenance and maturation, such as metabolic activity, biofilm thickness, roughness, extracellular polysaccharides production, and morphology of both pathogens, were altered by SRM-S-8 in the flow system.	Polysaccharides	156-171	ribosomal protein S8	Homo sapiens	238-241
27592162-1	2017	BACKGROUND: Equine type 1 polysaccharide storage myopathy (PSSM1) is associated with a missense mutation (R309H) in the glycogen synthase (GYS1) gene, enhanced glycogen synthase (GS) activity and excessive glycogen and amylopectate inclusions in muscle.	Polysaccharides	26-40	glycogen synthase 1	Equus caballus	139-143
28685146-8	2017	We hypothesize that in the case of glycosylated proteins the tag/C-terminal interaction positions the FLAG peptide in close proximity to the glycans thus sterically impeding the enterokinase access to its recognition site.	Polysaccharides	141-148	long intergenic non-protein coding RNA 1194	Homo sapiens	61-64
29147656-1	2017	An efficient procedure for ultrasound-assisted enzymatic extraction of crude polysaccharides from Trichosanthes Fructus (crude TFP) using response surface methodology (RSM) was developed.	Polysaccharides	77-92	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	127-130
28552066-2	2017	Hyaluronic acid is a type of polysaccharide that has been extensively studied as a selective targeting ligand to cancerous cells that overexpress its specific receptor CD44.	Polysaccharides	29-43	CD44 molecule (Indian blood group)	Homo sapiens	168-172
28093996-7	2017	Also, alpha-glucosidase inhibitors decrease the polysaccharides" digestion in small intestine and are less effective in comparison to metformin and sulfonylureas in lowering hemoglobin A1c (HbA1c).	Polysaccharides	48-63	sucrase-isomaltase	Homo sapiens	6-23
27720964-3	2017	Recently, we revealed that a novel megamolecular polysaccharide, sacran, has potential properties as a biomaterial in a physically cross-linked hydrogel film (HGF) for wound dressing application.	Polysaccharides	49-63	hepatocyte growth factor	Mus musculus	159-162
27871849-10	2017	In conclusion, engineering the glycan of CD44 on MSCs through FTVI transfection might enhance renotropism and the regenerating ability of MSCs in ischemic kidney injury.	Polysaccharides	31-37	CD44 antigen	Mus musculus	41-45
27769927-3	2017	The LRP-1 and LRP-2 were polysaccharide-protein complexes (46-68% beta-d-glucan and 27-48% protein), while LRP-3 and LRP-4 were absolutely composed of beta-d-glucose.	Polysaccharides	25-39	low density lipoprotein receptor-related protein 1	Mus musculus	4-7
29358974-5	2017	The level of the cytokine IL-10 in sera of cyclophosphamide-induced mice was decreased after pretreatments of polysaccharides.	Polysaccharides	110-125	interleukin 10	Mus musculus	26-31
28133813-4	2017	A more comprehensive and higher resolution understanding of the glycan shield has also emerged, enabling a more complete representation of the Env glycoprotein structure.	Polysaccharides	64-70	endogenous retrovirus group K member 20	Homo sapiens	143-146
28133813-5	2017	Complexes of Env trimers with broadly neutralizing antibodies have surprisingly illustrated that most of the Env surface can be targeted in natural infection and that the neutralizing epitopes are almost all composed of both peptide and glycan components.	Polysaccharides	237-243	endogenous retrovirus group K member 20	Homo sapiens	13-16
27769927-3	2017	The LRP-1 and LRP-2 were polysaccharide-protein complexes (46-68% beta-d-glucan and 27-48% protein), while LRP-3 and LRP-4 were absolutely composed of beta-d-glucose.	Polysaccharides	25-39	low density lipoprotein receptor-related protein 1	Mus musculus	14-17
29431066-3	2017	We examined the differential effects of this purified polysaccharide, named EP-1, on the human gastric (GES-1) cell line and a precancerous cell line (MC) that was transformed from GES-1 using N-methyl-N"-nitro-N-nitrosoguanidine.	Polysaccharides	54-68	prostaglandin E receptor 1	Homo sapiens	76-80
27769927-3	2017	The LRP-1 and LRP-2 were polysaccharide-protein complexes (46-68% beta-d-glucan and 27-48% protein), while LRP-3 and LRP-4 were absolutely composed of beta-d-glucose.	Polysaccharides	25-39	low density lipoprotein receptor-related protein 1	Mus musculus	14-17
27769927-3	2017	The LRP-1 and LRP-2 were polysaccharide-protein complexes (46-68% beta-d-glucan and 27-48% protein), while LRP-3 and LRP-4 were absolutely composed of beta-d-glucose.	Polysaccharides	25-39	low density lipoprotein receptor-related protein 1	Mus musculus	14-17
28605336-0	2017	Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) and IL-23 Induced by Polysaccharide of the Black Hoof Medicinal Mushroom, Phellinus linteus (Agaricomycetes).	Polysaccharides	70-84	tissue inhibitor of metalloproteinase 1	Mus musculus	0-39
28605336-0	2017	Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) and IL-23 Induced by Polysaccharide of the Black Hoof Medicinal Mushroom, Phellinus linteus (Agaricomycetes).	Polysaccharides	70-84	tissue inhibitor of metalloproteinase 1	Mus musculus	41-47
28605336-0	2017	Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) and IL-23 Induced by Polysaccharide of the Black Hoof Medicinal Mushroom, Phellinus linteus (Agaricomycetes).	Polysaccharides	70-84	interleukin 23, alpha subunit p19	Mus musculus	53-58
28605336-4	2017	We found that TIMP-1 and interleukin (IL)-23 are induced in RAW264.7 macrophage cells, a cell line established by Abelson leukemia virus transformation from the BALB/c mouse strain, in a dose-dependent pattern, at the transcriptional level by treatment with a crude polysaccharide fraction of Phellinus linteus (CPP) at a range of 10 to 1000 mug/mL.	Polysaccharides	266-280	tissue inhibitor of metalloproteinase 1	Mus musculus	14-20
27693834-3	2017	It was found that the polysaccharide administration could significantly up-regulate the expression of occludin, nuclear factor-kappaB p65 (NF-kappaB p65) and secretory immunoglobulin A (SIgA) in ileum, markedly improve the levels of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4, and decrease the level of diamine oxidase (DAO) in serum.	Polysaccharides	22-36	occludin	Rattus norvegicus	102-110
27693834-3	2017	It was found that the polysaccharide administration could significantly up-regulate the expression of occludin, nuclear factor-kappaB p65 (NF-kappaB p65) and secretory immunoglobulin A (SIgA) in ileum, markedly improve the levels of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4, and decrease the level of diamine oxidase (DAO) in serum.	Polysaccharides	22-36	interferon gamma	Rattus norvegicus	233-249
27693834-3	2017	It was found that the polysaccharide administration could significantly up-regulate the expression of occludin, nuclear factor-kappaB p65 (NF-kappaB p65) and secretory immunoglobulin A (SIgA) in ileum, markedly improve the levels of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4, and decrease the level of diamine oxidase (DAO) in serum.	Polysaccharides	22-36	interferon gamma	Rattus norvegicus	251-260
27693834-3	2017	It was found that the polysaccharide administration could significantly up-regulate the expression of occludin, nuclear factor-kappaB p65 (NF-kappaB p65) and secretory immunoglobulin A (SIgA) in ileum, markedly improve the levels of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4, and decrease the level of diamine oxidase (DAO) in serum.	Polysaccharides	22-36	interleukin 2	Rattus norvegicus	263-276
27693834-3	2017	It was found that the polysaccharide administration could significantly up-regulate the expression of occludin, nuclear factor-kappaB p65 (NF-kappaB p65) and secretory immunoglobulin A (SIgA) in ileum, markedly improve the levels of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4, and decrease the level of diamine oxidase (DAO) in serum.	Polysaccharides	22-36	interleukin 2	Rattus norvegicus	278-282
27693834-3	2017	It was found that the polysaccharide administration could significantly up-regulate the expression of occludin, nuclear factor-kappaB p65 (NF-kappaB p65) and secretory immunoglobulin A (SIgA) in ileum, markedly improve the levels of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4, and decrease the level of diamine oxidase (DAO) in serum.	Polysaccharides	22-36	interleukin 4	Rattus norvegicus	289-293
27693834-3	2017	It was found that the polysaccharide administration could significantly up-regulate the expression of occludin, nuclear factor-kappaB p65 (NF-kappaB p65) and secretory immunoglobulin A (SIgA) in ileum, markedly improve the levels of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4, and decrease the level of diamine oxidase (DAO) in serum.	Polysaccharides	22-36	amine oxidase, copper containing 1	Rattus norvegicus	321-336
27693834-3	2017	It was found that the polysaccharide administration could significantly up-regulate the expression of occludin, nuclear factor-kappaB p65 (NF-kappaB p65) and secretory immunoglobulin A (SIgA) in ileum, markedly improve the levels of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), and IL-4, and decrease the level of diamine oxidase (DAO) in serum.	Polysaccharides	22-36	amine oxidase, copper containing 1	Rattus norvegicus	338-341
27871117-1	2017	A water-soluble polysaccharide (SCP-80-I) was isolated from sweet corncob using microwave-assisted compound-enzyme extraction and column chromatography.	Polysaccharides	16-30	cysteine-rich secretory protein 3	Rattus norvegicus	32-35
27834568-5	2017	We show that an N-linked complex-type Fab glycan in H-CDR2 of 37E1B5 is directly involved in the inhibition of latent TGF-beta activation.	Polysaccharides	42-48	FA complementation group B	Homo sapiens	38-41
28164139-0	2017	Dietary Supplementation of Astragalus Polysaccharides Enhanced Immune Components and Growth Factors EGF and IGF-1 in Sow Colostrum.	Polysaccharides	38-53	epidermal growth factor	Homo sapiens	100-103
28164139-0	2017	Dietary Supplementation of Astragalus Polysaccharides Enhanced Immune Components and Growth Factors EGF and IGF-1 in Sow Colostrum.	Polysaccharides	38-53	insulin like growth factor 1	Homo sapiens	108-113
27625157-6	2017	The body of Lactobacillus spp., though red, turned yellow when interacting with the green extracellular polysaccharides.	Polysaccharides	104-119	histocompatibility minor 13	Homo sapiens	26-29
27834568-8	2017	This unique, H-CDR2 glycan-mediated mechanism may account for the potent but tolerable TGF-b activation inhibition and lack of an effect on cellular adhesion by the antibody.	Polysaccharides	20-26	cerebellar degeneration related protein 2	Homo sapiens	15-19
28204541-5	2017	Glycome profiling analysis showed that both overall cell wall polysaccharide extractability and relative extractability of specific pectin and xylan epitopes were affected in pgm, suggesting extensive structural changes in pgm cell walls.	Polysaccharides	62-76	phosphoglucomutase	Arabidopsis thaliana	175-178
27660893-1	2017	Ricin is an A-B ribosome inactivating protein (RIP) toxin composed of an A-chain subunit (RTA) that contains a catalytic N-glycosidase and a B-chain (RTB) lectin domain that binds cell surface glycans.	Polysaccharides	193-200	MAS related GPR family member F	Homo sapiens	90-93
27834568-8	2017	This unique, H-CDR2 glycan-mediated mechanism may account for the potent but tolerable TGF-b activation inhibition and lack of an effect on cellular adhesion by the antibody.	Polysaccharides	20-26	transforming growth factor beta 1	Homo sapiens	87-92
27834568-5	2017	We show that an N-linked complex-type Fab glycan in H-CDR2 of 37E1B5 is directly involved in the inhibition of latent TGF-beta activation.	Polysaccharides	42-48	cerebellar degeneration related protein 2	Homo sapiens	54-58
27834568-5	2017	We show that an N-linked complex-type Fab glycan in H-CDR2 of 37E1B5 is directly involved in the inhibition of latent TGF-beta activation.	Polysaccharides	42-48	transforming growth factor beta 1	Homo sapiens	118-126
28935106-8	2017	EPO was engineered to carry azide-tagged Man3GlcNAc2 glycans that could be further modified via click chemistry to introduce other functional groups.	Polysaccharides	53-60	erythropoietin	Homo sapiens	0-3
28566667-1	2017	The dermatophyte antigen kit uses monoclonal antibodies that react with polysaccharides present in the dermatophyte cell wall to detect dermatophyte antigens in specimens based on the principle of immunochromatography.	Polysaccharides	72-87	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	25-28
28935112-2	2017	The central enzyme in N-linked glycosylation is the oligosaccharyltransferase (OST), which catalyzes the covalent attachment of preassembled glycans to specific asparagine residues in target proteins.	Polysaccharides	141-148	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	52-77
28935112-2	2017	The central enzyme in N-linked glycosylation is the oligosaccharyltransferase (OST), which catalyzes the covalent attachment of preassembled glycans to specific asparagine residues in target proteins.	Polysaccharides	141-148	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	79-82
27922683-6	2017	In silico docking analysis demonstrated that polysaccharides may not interfere with dimerization, whereas, the affinity of polysaccharides for an S100A4-NMIIA pocket was margnially greater than at the dimerization sites.	Polysaccharides	123-138	S100 calcium binding protein A4	Bos taurus	146-152
27873210-4	2017	Glycan immobilization on microarrays allows rapid, multiplexed glycan-GBP interaction studies to reveal biological functions.	Polysaccharides	0-6	transmembrane protein 132A	Homo sapiens	70-73
27873210-4	2017	Glycan immobilization on microarrays allows rapid, multiplexed glycan-GBP interaction studies to reveal biological functions.	Polysaccharides	63-69	transmembrane protein 132A	Homo sapiens	70-73
27873210-6	2017	Here, we describe the methods to fabricate custom glycan microarrays that are used to examine glycan-GBP binding specificities.	Polysaccharides	50-56	transmembrane protein 132A	Homo sapiens	101-104
27743372-10	2017	Rapid separation of APTS labeled IgG glycans is also shown utilizing an optimized CE-LIF protocol.	Polysaccharides	37-44	LIF interleukin 6 family cytokine	Homo sapiens	85-88
28215308-5	2017	In the present review, the mechanisms by which BDNF is released from secretory vesicles are reviewed, with a particular focus on the recently described glycan-mediated release.	Polysaccharides	152-158	brain derived neurotrophic factor	Homo sapiens	47-51
26738850-2	2017	Very little is known about the regulation of the HNK-1 glycan in neurodegenerative disease, particularly in Alzheimer"s disease (AD).	Polysaccharides	55-61	beta-1,3-glucuronyltransferase 1	Homo sapiens	49-54
29147463-0	2017	Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-kappaB Activation.	Polysaccharides	7-21	hepcidin antimicrobial peptide	Homo sapiens	122-130
29147463-0	2017	Acidic Polysaccharide from Angelica sinensis Reverses Anemia of Chronic Disease Involving the Suppression of Inflammatory Hepcidin and NF-kappaB Activation.	Polysaccharides	7-21	nuclear factor kappa B subunit 1	Homo sapiens	135-144
27643972-8	2017	The assignment of a direct role for GIPC glycan head groups in the impaired processes in iput1 mutants is complicated by the vast compensatory changes in the sphingolipidome; however, our results reveal that the glycosylation steps of GIPC biosynthesis are important regulated components of sphingolipid metabolism.	Polysaccharides	41-47	plant glycogenin-like starch initiation protein 6	Arabidopsis thaliana	89-94
29225398-4	2017	Ionizing radiation causes significant break down of the polysaccharides and leads to the production of potentially useful gaseous products such as H2 and CO.	Polysaccharides	56-71	relaxin 2	Homo sapiens	147-156
29456783-2	2017	Unlike other glycans, O-GlcNAc is a highly dynamic and reversible process that involves the addition and removal of a single N-acetylglucosamine molecule to Ser/Thr residues of proteins.	Polysaccharides	13-20	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	22-30
28215308-6	2017	In addition, the impact of glycan-mediated BDNF release on psychiatric disorders is also discussed.	Polysaccharides	27-33	brain derived neurotrophic factor	Homo sapiens	43-47
27938679-11	2016	The latter inhibition was higher than Env, suggesting that the oligosaccharides could be also involved in the glycan shield for viral escape.	Polysaccharides	110-116	endogenous retrovirus group W member 1, envelope	Homo sapiens	38-41
27793989-0	2016	The Role of Sialylated Glycans in Human Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)-mediated Trans Homophilic Interactions and Endothelial Cell Barrier Function.	Polysaccharides	23-30	platelet and endothelial cell adhesion molecule 1	Homo sapiens	40-85
27992432-7	2016	Glycan analysis showed that MUC5AC produced by a subset of mucinous cysts displays terminal alpha-GlcNAc, a motif expressed in stomach glands.	Polysaccharides	0-6	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	28-34
27997616-2	2016	In this study, a water soluble polysaccharide, which we designated as UP2, with an average molecular weight of 3.33 x 105 Da, was isolated from U. esculenta cultivated in the Huangshan Mountain, by consecutive hot water extraction and anion-exchange chromatography.	Polysaccharides	31-45	uroplakin 2	Mus musculus	70-73
27793989-0	2016	The Role of Sialylated Glycans in Human Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)-mediated Trans Homophilic Interactions and Endothelial Cell Barrier Function.	Polysaccharides	23-30	platelet and endothelial cell adhesion molecule 1	Homo sapiens	87-94
27793989-3	2016	PECAM-1 glycans account for ~30% of its molecular mass, and the newly solved crystal structure of human PECAM-1 immunoglobulin homology domain 1 reveals that a glycan emanating from the asparagine residue at position 25 (Asn-25) is located within the trans homophilic-binding interface, suggesting a role for an Asn-25-associated glycan in PECAM-1 homophilic interactions.	Polysaccharides	8-15	platelet and endothelial cell adhesion molecule 1	Homo sapiens	0-7
27793989-3	2016	PECAM-1 glycans account for ~30% of its molecular mass, and the newly solved crystal structure of human PECAM-1 immunoglobulin homology domain 1 reveals that a glycan emanating from the asparagine residue at position 25 (Asn-25) is located within the trans homophilic-binding interface, suggesting a role for an Asn-25-associated glycan in PECAM-1 homophilic interactions.	Polysaccharides	8-14	platelet and endothelial cell adhesion molecule 1	Homo sapiens	0-7
27793989-3	2016	PECAM-1 glycans account for ~30% of its molecular mass, and the newly solved crystal structure of human PECAM-1 immunoglobulin homology domain 1 reveals that a glycan emanating from the asparagine residue at position 25 (Asn-25) is located within the trans homophilic-binding interface, suggesting a role for an Asn-25-associated glycan in PECAM-1 homophilic interactions.	Polysaccharides	160-166	platelet and endothelial cell adhesion molecule 1	Homo sapiens	104-111
27793989-3	2016	PECAM-1 glycans account for ~30% of its molecular mass, and the newly solved crystal structure of human PECAM-1 immunoglobulin homology domain 1 reveals that a glycan emanating from the asparagine residue at position 25 (Asn-25) is located within the trans homophilic-binding interface, suggesting a role for an Asn-25-associated glycan in PECAM-1 homophilic interactions.	Polysaccharides	160-166	platelet and endothelial cell adhesion molecule 1	Homo sapiens	104-111
27793989-7	2016	Taken together, these data suggest that a sialic acid-containing glycan emanating from Asn-25 reinforces dynamic endothelial cell-cell interactions by stabilizing the PECAM-1 homophilic binding interface.	Polysaccharides	65-71	platelet and endothelial cell adhesion molecule 1	Homo sapiens	167-174
27791356-5	2016	ROA indicated that the protein backbone of MUC5B is dominated by unordered conformation, which was found to originate from the heavily glycosylated central mucin domain by isolation of MUC5B O-glycan-rich regions.	Polysaccharides	193-199	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	43-48
27917827-2	2016	As a rare occurrence, the N14 Fab is N-glycosylated at Asn26L at the onset of the VL1 antigen-binding loop, with the alpha-1-6 core fucosylated complex glycan facing out of the L1 complementarity-determining region.	Polysaccharides	152-158	FA complementation group B	Homo sapiens	30-33
27809484-9	2016	A glycan on MUC5AC that is associated with cancer had mostly 2,3-linked sialic acid, whereas other glycans on MUC5AC had a 2,6 linkage of sialic acid.	Polysaccharides	2-8	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	12-18
27809484-9	2016	A glycan on MUC5AC that is associated with cancer had mostly 2,3-linked sialic acid, whereas other glycans on MUC5AC had a 2,6 linkage of sialic acid.	Polysaccharides	99-106	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	110-116
27809484-10	2016	The on-chip glycan modification and probing (on-chip GMAP) method provides a platform for analyzing protein glycosylation in clinical specimens and could complement the existing toolkit for studying glycosylation in disease.	Polysaccharides	12-18	galanin and GMAP prepropeptide	Homo sapiens	53-57
27917827-2	2016	As a rare occurrence, the N14 Fab is N-glycosylated at Asn26L at the onset of the VL1 antigen-binding loop, with the alpha-1-6 core fucosylated complex glycan facing out of the L1 complementarity-determining region.	Polysaccharides	152-158	adrenoceptor alpha 1D	Homo sapiens	117-126
27847204-4	2016	By using ELISA and western blot assay, the expression level of IFN-alpha and IRF3 and their functional roles in polysaccharide-mediated antiviral activity against RSV were investigated.	Polysaccharides	112-126	interferon alpha 1	Homo sapiens	63-72
27753515-3	2016	Substantial redundancy exists in the precise recruitment mechanism for TBK1 because engagement with any of several Salmonella-associated "eat-me" signals, including host-derived glycans, and K48- and K63-linked ubiquitin chains, suffices to recruit TBK1 functionality.	Polysaccharides	178-185	TANK binding kinase 1	Homo sapiens	71-75
27955748-6	2016	These polysaccharide extracts of JCEM, PCEM and EHEM produced significant decrease in serum AFP, CEA, GPC-3, HGF and VEGF compared with untreated HCC group.	Polysaccharides	6-20	alpha-fetoprotein	Rattus norvegicus	92-95
27955748-6	2016	These polysaccharide extracts of JCEM, PCEM and EHEM produced significant decrease in serum AFP, CEA, GPC-3, HGF and VEGF compared with untreated HCC group.	Polysaccharides	6-20	CEA cell adhesion molecule 20	Rattus norvegicus	97-100
27955748-6	2016	These polysaccharide extracts of JCEM, PCEM and EHEM produced significant decrease in serum AFP, CEA, GPC-3, HGF and VEGF compared with untreated HCC group.	Polysaccharides	6-20	glypican 3	Rattus norvegicus	102-107
27955748-6	2016	These polysaccharide extracts of JCEM, PCEM and EHEM produced significant decrease in serum AFP, CEA, GPC-3, HGF and VEGF compared with untreated HCC group.	Polysaccharides	6-20	hepatocyte growth factor	Rattus norvegicus	109-112
27955748-6	2016	These polysaccharide extracts of JCEM, PCEM and EHEM produced significant decrease in serum AFP, CEA, GPC-3, HGF and VEGF compared with untreated HCC group.	Polysaccharides	6-20	vascular endothelial growth factor A	Rattus norvegicus	117-121
27847204-4	2016	By using ELISA and western blot assay, the expression level of IFN-alpha and IRF3 and their functional roles in polysaccharide-mediated antiviral activity against RSV were investigated.	Polysaccharides	112-126	interferon regulatory factor 3	Homo sapiens	77-81
27847204-8	2016	The polysaccharide extract improved IRF-3 expression which promoted the level of IFN-alpha.	Polysaccharides	4-18	interferon regulatory factor 3	Homo sapiens	36-41
27847204-8	2016	The polysaccharide extract improved IRF-3 expression which promoted the level of IFN-alpha.	Polysaccharides	4-18	interferon alpha 1	Homo sapiens	81-90
27847204-9	2016	IN CONCLUSION: Polysaccharide extract from Laminaria japonica elicits antiviral activity against RSV by up-regulation of IRF3 signaling-mediated IFN-alpha production.	Polysaccharides	15-29	interferon regulatory factor 3	Homo sapiens	121-125
27847204-9	2016	IN CONCLUSION: Polysaccharide extract from Laminaria japonica elicits antiviral activity against RSV by up-regulation of IRF3 signaling-mediated IFN-alpha production.	Polysaccharides	15-29	interferon alpha 1	Homo sapiens	145-154
26306417-0	2016	Therapeutic and immunoregulatory effect of GATA-binding protein-3/T-box expressed in T-cells ratio of astragalus polysaccharides on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats.	Polysaccharides	113-128	GATA binding protein 3	Rattus norvegicus	43-65
27732771-6	2016	In addition, previous studies have demonstrated that VWF glycans play a key role in regulating in vivo clearance.	Polysaccharides	57-64	Von Willebrand factor	Mus musculus	53-56
27545408-2	2016	This study aimed to investigate the therapeutic effect and metabolic mechanism of a polysaccharide (SCP) from Schisandra chinensis fruits on chronic fatigue syndrome (CFS).	Polysaccharides	84-98	cysteine-rich secretory protein 3	Rattus norvegicus	100-103
27545408-5	2016	The results showed that SCP is a protein-bound polysaccharide.	Polysaccharides	47-61	cysteine-rich secretory protein 3	Rattus norvegicus	24-27
27576948-0	2016	A polysaccharide from Pinellia ternata inhibits cell proliferation and metastasis in human cholangiocarcinoma cells by targeting of Cdc42 and 67kDa Laminin Receptor (LR).	Polysaccharides	2-16	cell division cycle 42	Homo sapiens	132-137
27576948-0	2016	A polysaccharide from Pinellia ternata inhibits cell proliferation and metastasis in human cholangiocarcinoma cells by targeting of Cdc42 and 67kDa Laminin Receptor (LR).	Polysaccharides	2-16	ribosomal protein SA	Homo sapiens	142-164
27576948-1	2016	In this study, we isolated and purified a polysaccharide (PTPA) from the tubers of Pinellia ternate.	Polysaccharides	42-56	protein phosphatase 2 phosphatase activator	Homo sapiens	58-62
27496765-7	2016	Furthermore, we showed that LARGE2 could modify several additional PGs with the laminin-binding glycan, most likely within the glycosaminoglycan (GAG)-protein linkage region.	Polysaccharides	96-102	LARGE xylosyl- and glucuronyltransferase 2	Homo sapiens	28-34
27591923-1	2016	In the present study, we isolated and characterized one purified polysaccharide (AEP-1) from the leaves of Aralia elata, and investigated its effect on human osteosarcoma (OS) U-2 OS cell line and analyzed its mechanism.	Polysaccharides	65-79	SPATA31 subfamily A member 7	Homo sapiens	81-86
27637449-1	2016	To research the preliminary characterizations, antioxidant and hepatoprotective activity of polysaccharides from Cistanche deserticola (CDPs), three polysaccharide fractions, CDP-A, CDP-B and CDP-C, were obtained by successively membrane filtration (microfiltration, ultrafiltration and nanofiltration).	Polysaccharides	92-107	cut like homeobox 1	Homo sapiens	136-139
27637449-1	2016	To research the preliminary characterizations, antioxidant and hepatoprotective activity of polysaccharides from Cistanche deserticola (CDPs), three polysaccharide fractions, CDP-A, CDP-B and CDP-C, were obtained by successively membrane filtration (microfiltration, ultrafiltration and nanofiltration).	Polysaccharides	92-106	cut like homeobox 1	Homo sapiens	136-139
27825050-1	2016	The aim of the study was to explore whether fever-range hyperthermia (FRH) might enhance the anticancer and immunoregulatory activities of protein-bound polysaccharides (PBP), a class of fungus derived immunomodifiers used in the cancer adjuvant therapy.	Polysaccharides	153-168	phosphatidylethanolamine binding protein 1	Rattus norvegicus	170-173
27748735-6	2016	We also report that apical membrane MECA-79 sulfated glycan expression colocalizes with that of mucin 1 (MUC1) core proteins.	Polysaccharides	53-59	mucin 1, cell surface associated	Homo sapiens	96-103
27748735-6	2016	We also report that apical membrane MECA-79 sulfated glycan expression colocalizes with that of mucin 1 (MUC1) core proteins.	Polysaccharides	53-59	mucin 1, cell surface associated	Homo sapiens	105-109
27748735-8	2016	Furthermore, we report that SSP-25 human ICC cells overexpressing N-acetylglucosamine-6-O-sulfotransferase 2 (GlcNAc6ST-2), but not GlcNAc6ST-1, exhibit membrane expression of MECA-79 sulfated glycans, suggesting that GlcNAc6ST-2 catalyzes MECA-79 epitope biosynthesis in cholangiocytes.	Polysaccharides	193-200	carbohydrate sulfotransferase 4	Homo sapiens	66-108
27748735-8	2016	Furthermore, we report that SSP-25 human ICC cells overexpressing N-acetylglucosamine-6-O-sulfotransferase 2 (GlcNAc6ST-2), but not GlcNAc6ST-1, exhibit membrane expression of MECA-79 sulfated glycans, suggesting that GlcNAc6ST-2 catalyzes MECA-79 epitope biosynthesis in cholangiocytes.	Polysaccharides	193-200	carbohydrate sulfotransferase 4	Homo sapiens	110-121
27748735-10	2016	These data collectively indicate that apical membrane localization of MUC1 proteins decorated with GlcNAc6ST-2-dependent MECA-79 sulfated glycans may mark cholangiocytes with cholangiolar/ductular differentiation and could serve as a useful CoCC marker.	Polysaccharides	138-145	mucin 1, cell surface associated	Homo sapiens	70-74
27748735-10	2016	These data collectively indicate that apical membrane localization of MUC1 proteins decorated with GlcNAc6ST-2-dependent MECA-79 sulfated glycans may mark cholangiocytes with cholangiolar/ductular differentiation and could serve as a useful CoCC marker.	Polysaccharides	138-145	carbohydrate sulfotransferase 4	Homo sapiens	99-110
27825050-12	2016	Combined treatment of rats (FRH+PBP) results in decrease of IL-1beta, IL-6 and TNF-alpha mRNA expression in peripheral blood mononuclear cells compared to cells derived from rats treated with protein-bound polysaccharides extract alone.	Polysaccharides	206-221	phosphatidylethanolamine binding protein 1	Rattus norvegicus	32-35
27729469-3	2016	We characterized EXPB1 binding to sequentially extracted maize CWs, finding that the protein primarily binds glucuronoarabinoxylan (GAX), the major matrix polysaccharide in grass CWs.	Polysaccharides	155-169	expansin-B1	Zea mays	17-22
27956273-6	2016	sLeX-type glycans were also expressed on DSPTC carcinoma cells, which in binding assays were decorated with E-selectin IgM chimaeras calcium-dependently.	Polysaccharides	10-17	selectin E	Homo sapiens	108-118
27956273-8	2016	Additionally, sLeX-type glycans on carcinoma cells might partly contribute to highly metastatic properties of DSPTC through interaction with E-selectin expressed on endothelial cells.	Polysaccharides	24-31	selectin E	Homo sapiens	141-151
27756823-6	2016	Lines with altered DEK1 activity have epidermis-specific changes in the thickness and polysaccharide composition of cell walls that likely underlie the loss of adhesion between epidermal cells in plants with reduced levels of DEK1 and changes in leaf shape and size in plants constitutively overexpressing the active CALPAIN domain of DEK1.	Polysaccharides	86-100	calpain-type cysteine protease family	Arabidopsis thaliana	19-23
26920336-3	2016	The biosensor showed presence of alpha-L-fucose and alpha-(2,6)-linked terminal sialic acid within PSA s glycan with high abundance, while only traces of alpha-(2,3)-linked terminal sialic acid were found.	Polysaccharides	105-111	kallikrein related peptidase 3	Homo sapiens	99-102
27744264-10	2016	Additionally, the mutant"s mycelium was more affected by treatments with chitinase and beta-1,3-glucanase, thus indicating that FgCPPs could protect fungal cell wall polysaccharides from enzymatic degradation.	Polysaccharides	166-181	glucan endo-1,3-beta-glucosidase 14	Triticum aestivum	87-105
27091793-6	2016	Fungal (Coprinopsis cinerea) galectin 2, CGL2, binds the Galbeta1-4Fuc on C. elegans glycans to exert its nematotoxicity.	Polysaccharides	85-92	granzyme H	Homo sapiens	41-45
27721143-0	2016	Function-spacer-lipid constructs of Lewis and chimeric Lewis/ABH glycans.	Polysaccharides	65-72	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	61-64
27582340-4	2016	As these glycans often represent highly regulatable post-translational modifications, alterations in glycosylation can fundamentally impact GBP recognition.	Polysaccharides	9-16	galectin 1	Homo sapiens	140-143
27707925-5	2016	Here, using longitudinal Env sequences from a clade C-infected individual (CAP256), we measured the impact of the shifting glycan shield during HIV infection on the abundance of oligomannose-type glycans.	Polysaccharides	196-203	endogenous retrovirus group K member 20	Homo sapiens	25-28
27893774-6	2016	By characterizing the Siglec-9-EC mutants, we could conclude that R120 in the V domain likely interacts with the terminal sialic acids of hAOC3 attached glycans whereas residues R284 and R290 in C22 are involved in the interactions with the active site channel of hAOC3.	Polysaccharides	153-160	amine oxidase copper containing 3	Homo sapiens	138-143
27893774-8	2016	To conclude, our results prove that the V and C22 domains of Siglec-9-EC interact with hAOC3 in a multifaceted and unique way, forming both glycan-mediated and direct protein-protein interactions, respectively.	Polysaccharides	140-146	sialic acid binding Ig like lectin 9	Homo sapiens	61-72
27893774-8	2016	To conclude, our results prove that the V and C22 domains of Siglec-9-EC interact with hAOC3 in a multifaceted and unique way, forming both glycan-mediated and direct protein-protein interactions, respectively.	Polysaccharides	140-146	amine oxidase copper containing 3	Homo sapiens	87-92
27884834-0	2016	Glycans of plasma ADAMTS13.	Polysaccharides	0-7	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	18-26
27561486-1	2016	Two polysaccharides CPA-1 and CPB-2 were isolated purified from Cordyceps cicadae by hot water extraction, ethanol precipitation and purification using anion exchange and gel filtration chromatography.	Polysaccharides	4-19	carboxypeptidase A1	Rattus norvegicus	20-25
27810711-4	2016	For assembly of glycans, a convergent 3+2+3 approach was developed producing two different octasaccharide amino acid cassettes, which were utilized towards syndecan-3 glycopeptides.	Polysaccharides	16-23	syndecan 3	Homo sapiens	156-166
27574189-0	2016	Identification of glycans on plasma-derived ADAMTS13.	Polysaccharides	18-25	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	44-52
27574189-2	2016	Here, we studied the glycan composition of plasma-derived ADAMTS13.	Polysaccharides	21-27	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	58-66
27574189-16	2016	Overall, our findings highlight the complexity of glycan modifications on ADAMTS13, which may have implications for its interaction with immune- or clearance receptors containing carbohydrate recognition domains.	Polysaccharides	50-56	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	74-82
27707925-7	2016	This effect of the glycan density on the processing state was also supported by the analysis of a cross-clade panel of recombinant gp120 glycoproteins.	Polysaccharides	19-25	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
27707925-11	2016	The HIV envelope glycoprotein (Env) is covered in an array of host-derived N-linked glycans often referred to as the glycan shield.	Polysaccharides	84-90	endogenous retrovirus group K member 20	Homo sapiens	8-29
27653286-8	2016	Postprocessing energetic analysis of this model provides a rationale for the role each glycan residue plays in the binding event, and examination of the binding site in the context of a previous Robo-Slit structure provides a rationale for modulation of Robo-Slit interactions by HS.	Polysaccharides	87-93	roundabout guidance receptor 1	Homo sapiens	195-199
27707925-11	2016	The HIV envelope glycoprotein (Env) is covered in an array of host-derived N-linked glycans often referred to as the glycan shield.	Polysaccharides	84-90	endogenous retrovirus group K member 20	Homo sapiens	31-34
27653286-8	2016	Postprocessing energetic analysis of this model provides a rationale for the role each glycan residue plays in the binding event, and examination of the binding site in the context of a previous Robo-Slit structure provides a rationale for modulation of Robo-Slit interactions by HS.	Polysaccharides	87-93	roundabout guidance receptor 1	Homo sapiens	254-258
27707925-13	2016	This study aimed to determine whether these genetic changes impacted the eventual processing of glycans on the HIV Env and the susceptibility of the virus to neutralization.	Polysaccharides	96-103	endogenous retrovirus group K member 20	Homo sapiens	115-118
27851917-3	2016	This CAR selectively binds MUC1 that carries the Tn or sialyl (S)Tn glycan.	Polysaccharides	68-74	nuclear receptor subfamily 1 group I member 3	Homo sapiens	5-8
27851829-5	2016	Further analysis comparing amino acid sequence changes, insertions/deletions, and glycan motif alterations between the T/F Env and autologous early Env variants revealed that extensive diversification focused in the V2, V4, and V5 regions of gp120, accompanied by contemporaneous viral escape, significantly favored the development of breadth.	Polysaccharides	82-88	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	242-247
27851829-6	2016	These results suggest that more efficient glycosylation of subtype A and C T/F Envs through fewer NXS-encoded glycan sites is more likely to elicit antibodies that can transition from autologous to heterologous neutralizing activity following exposure to gp120 diversification.	Polysaccharides	110-116	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	255-260
27851917-3	2016	This CAR selectively binds MUC1 that carries the Tn or sialyl (S)Tn glycan.	Polysaccharides	68-74	mucin 1, cell surface associated	Homo sapiens	27-31
27851917-4	2016	Both of these truncated glycans are aberrantly expressed on the MUC1 glycoprotein in a spectrum of malignancies and consequently represent attractive targets for immunotherapeutic exploitation.	Polysaccharides	24-31	mucin 1, cell surface associated	Homo sapiens	64-68
27495851-0	2016	Mapping insulin non-covalent interactions with natural polysaccharides by hydrogen/deuterium exchange mass spectrometry.	Polysaccharides	55-70	insulin	Homo sapiens	8-15
27495851-3	2016	Here amide hydrogen/deuterium exchange (HDX) mass spectrometry was employed to localize insulin dynamics induced by interactions with three natural polysaccharides, i.e. chitosan (CH), sodium alginate (ALG) and chondroitin sulfate (CS).	Polysaccharides	148-163	insulin	Homo sapiens	88-95
27495851-6	2016	RESULTS: Differences in the insulin backbone dynamics in the presence of the three polysaccharides were highlighted by monitoring peptic peptides at different time points.	Polysaccharides	83-98	insulin	Homo sapiens	28-35
27495851-10	2016	CONCLUSIONS: The studies reported here demonstrated the capabilities of mass spectrometry techniques and HDX methods to obtain useful information toward the flexibility and the behavior of native insulin in the presence of natural polysaccharides, and could provide insights to study the behavior of pharmaceutical formulations.	Polysaccharides	231-246	insulin	Homo sapiens	196-203
27762044-3	2016	A cathepsin B-specific cleavable substrate (KGRR) conjugated with triacetylated N-azidoacetyl-d-mannosamine (RR-S-Ac3 ManNAz) was developed to enable tumor cells to generate unnatural glycans that contain azide groups.	Polysaccharides	184-191	cathepsin B	Mus musculus	2-13
27639309-2	2016	Gaining insight into the native presentation and distribution of glycans across hSP could help establish molecular environments supporting specific biological activities based on unique ligand capacities.	Polysaccharides	65-72	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	80-83
27669574-2	2016	Each binds to high-mannose glycans on the surface envelope glycoprotein gp120, yet the mechanisms by which they engage viral spikes and exhibit inhibition constants ranging from nanomolar to picomolar are not understood.	Polysaccharides	27-34	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	72-77
27722689-0	2016	Sargassum fusiforme polysaccharides activate antioxidant defense by promoting Nrf2-dependent cytoprotection and ameliorate stress insult during aging.	Polysaccharides	20-35	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
27538373-3	2016	With a highly polymorphic structure, both in the polypeptide and glycan counterparts, MUC1 variability has been associated with susceptibility to several diseases, including cancer.	Polysaccharides	65-71	mucin 1, cell surface associated	Homo sapiens	86-90
27516321-0	2016	Structural characterization and antiviral effect of a novel polysaccharide PSP-2B from Prunellae Spica.	Polysaccharides	60-74	regenerating family member 1 beta	Homo sapiens	75-80
27647012-8	2016	In addition, nuclear translocation assays demonstrate that the stress response transcription factor DAF-16/FOXO was involved in the antioxidant activity of the polysaccharide.	Polysaccharides	160-174	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	100-106
27639309-7	2016	Insight into the complexity of hSP glycans as recognition signals under normal physiological conditions could be of interest for regulation and possible modulation of its biological activity, as well as for biomarker potential related to male health.	Polysaccharides	35-42	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	31-34
27333379-7	2016	Here, we expand our engineering repertoire by in planta generation of galactose-deficient and alpha2,6-sialylated O-glycans which are the prevailing glycans detected on IgA1 from patients with IgAN.	Polysaccharides	116-123	immunoglobulin heavy constant alpha 1	Homo sapiens	169-173
27592080-6	2016	Structural analysis of PCPS suggests that this polysaccharide is a beta-1,3-branched beta-1,6-glucan, which is in line with its capacity to activate Dectin-1.	Polysaccharides	47-61	C-type lectin domain containing 7A	Homo sapiens	149-157
27696685-6	2016	We also characterized ECP neutralizing activity using progressively truncated LPS mutants, and conclude that the polysaccharide moiety and lipid A portions are required for LPS-mediated neutralization.	Polysaccharides	113-127	ribonuclease A family member 3	Homo sapiens	22-25
27510804-1	2016	Mucopolysaccharidosis type II (MPS II) is a rare X-linked genetic disorder caused by deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS), leading to impaired catabolism of ubiquitous polysaccharides and abnormal accumulation of these undegraded substrates in the lysosome.	Polysaccharides	194-209	iduronate 2-sulfatase	Mus musculus	120-141
27510804-1	2016	Mucopolysaccharidosis type II (MPS II) is a rare X-linked genetic disorder caused by deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS), leading to impaired catabolism of ubiquitous polysaccharides and abnormal accumulation of these undegraded substrates in the lysosome.	Polysaccharides	194-209	iduronate 2-sulfatase	Mus musculus	143-146
26381157-1	2016	Glycan conversion of glycoprotein via the transglycosylation activity of endo-beta-N-acetylglucosaminidase is a promising chemoenzymatic technology for the production of glycoproteins including bio-medicines with a homogeneous glycoform.	Polysaccharides	0-6	O-GlcNAcase	Homo sapiens	78-106
27037304-2	2016	A subset of these adhesins, expressed by oral streptococci, binds sialylated glycans decorating human salivary mucin MG2/MUC7, and platelet glycoprotein GPIb.	Polysaccharides	77-84	mucin 7, secreted	Homo sapiens	117-120
27037304-2	2016	A subset of these adhesins, expressed by oral streptococci, binds sialylated glycans decorating human salivary mucin MG2/MUC7, and platelet glycoprotein GPIb.	Polysaccharides	77-84	mucin 7, secreted	Homo sapiens	121-125
27343171-12	2016	In conclusion, the Der p 7 is a glycoprotein and its function was partially through glycan binding.	Polysaccharides	84-90	exosome component 2	Homo sapiens	23-26
27431791-5	2016	The results indicate that herbal polysaccharides provide a good prospect in prevention and treatment of IR injury, and these kinds of polysaccharides have various mechanisms of action, including (i) modifying the function of neurosystem, (ii) reducing the infarct volume, malondiadehyde (MDA) content, and levels of pro-inflammatory cytokines, (iii) elevating the activities of superoxide dismutase (SOD) and myeloperoxidase (MPO) and increasing the levels of anti-inflammatory cytokine.	Polysaccharides	33-48	myeloperoxidase	Homo sapiens	409-424
27431791-5	2016	The results indicate that herbal polysaccharides provide a good prospect in prevention and treatment of IR injury, and these kinds of polysaccharides have various mechanisms of action, including (i) modifying the function of neurosystem, (ii) reducing the infarct volume, malondiadehyde (MDA) content, and levels of pro-inflammatory cytokines, (iii) elevating the activities of superoxide dismutase (SOD) and myeloperoxidase (MPO) and increasing the levels of anti-inflammatory cytokine.	Polysaccharides	33-48	myeloperoxidase	Homo sapiens	426-429
27377460-1	2016	A water-soluble polysaccharide (BP-1) was obtained from highland barley (Hordeum vulgare L.) by hot water extraction and purification of sepharose column chromatography.	Polysaccharides	16-30	BP1	Homo sapiens	32-36
27431791-5	2016	The results indicate that herbal polysaccharides provide a good prospect in prevention and treatment of IR injury, and these kinds of polysaccharides have various mechanisms of action, including (i) modifying the function of neurosystem, (ii) reducing the infarct volume, malondiadehyde (MDA) content, and levels of pro-inflammatory cytokines, (iii) elevating the activities of superoxide dismutase (SOD) and myeloperoxidase (MPO) and increasing the levels of anti-inflammatory cytokine.	Polysaccharides	134-149	myeloperoxidase	Homo sapiens	409-424
27431791-5	2016	The results indicate that herbal polysaccharides provide a good prospect in prevention and treatment of IR injury, and these kinds of polysaccharides have various mechanisms of action, including (i) modifying the function of neurosystem, (ii) reducing the infarct volume, malondiadehyde (MDA) content, and levels of pro-inflammatory cytokines, (iii) elevating the activities of superoxide dismutase (SOD) and myeloperoxidase (MPO) and increasing the levels of anti-inflammatory cytokine.	Polysaccharides	134-149	myeloperoxidase	Homo sapiens	426-429
27601598-3	2016	However, the in vivo functional roles remain equivocal for enzymes such as ISPD, FKTN, FKRP, and TMEM5 that are supposed to be involved in post-phosphoryl modifications linking the GalNAc-beta3-GlcNAc-beta4-Man-6-phosphate core and the outer laminin-binding glycans.	Polysaccharides	258-265	fukutin	Homo sapiens	81-85
27554335-3	2016	The aim of this study is to explore the role of DC-SIGN in capturing and processing glycan-containing allergens and in the subsequent DC activation and T helper cell polarization in AD patients.	Polysaccharides	84-90	CD209 molecule	Homo sapiens	48-55
27622344-5	2016	The hydrophobicity index and EPS (extracellular polysaccharide) production of both Gram positive and Gram negative bacteria was decreased after treatment with 30 mug mL-1 of CS/Ag/ZnO nanocomposite.	Polysaccharides	48-62	L1 cell adhesion molecule	Mus musculus	166-170
27492264-7	2016	Adding galactose to the non-reducing termini of the complex-type, biantennary glycan increased affinity for all CD16s and 32s tested by 1.7-fold.	Polysaccharides	78-84	Fc gamma receptor IIIa	Homo sapiens	112-116
27601598-3	2016	However, the in vivo functional roles remain equivocal for enzymes such as ISPD, FKTN, FKRP, and TMEM5 that are supposed to be involved in post-phosphoryl modifications linking the GalNAc-beta3-GlcNAc-beta4-Man-6-phosphate core and the outer laminin-binding glycans.	Polysaccharides	258-265	fukutin related protein	Homo sapiens	87-91
27601598-3	2016	However, the in vivo functional roles remain equivocal for enzymes such as ISPD, FKTN, FKRP, and TMEM5 that are supposed to be involved in post-phosphoryl modifications linking the GalNAc-beta3-GlcNAc-beta4-Man-6-phosphate core and the outer laminin-binding glycans.	Polysaccharides	258-265	ribitol xylosyltransferase 1	Homo sapiens	97-102
27529448-6	2016	However, RSL and GL-supplementation increased abundance of several taxa involved in plant polysaccharide degradation/fermentation.	Polysaccharides	90-104	regulator of sex limited protein-Slp	Mus musculus	9-12
26960182-5	2016	Binding to MUC16 was independent of IgG subclass, but strongly associated with shorter Ab glycan profiles, with agalactosylated (G0) Abs demonstrating the highest binding to MUC16.	Polysaccharides	90-96	mucin 16, cell surface associated	Homo sapiens	11-16
27783665-12	2016	Among the tested SG, beta-1,3-glucan sulfates with a Mr &lt;= 10 000 were identified as most promising lead candidates for the development of a glycan-based C1-INH amplifier.	Polysaccharides	144-150	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	21-29
27601404-7	2016	Furthermore, total serum glycomics of STAM mouse were unveiled as an initial step to identify novel biomarkers of liver diseases, with which we could identify several glycans with expression significantly increased or decreased expression.	Polysaccharides	167-174	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	Mus musculus	38-42
27554431-4	2016	Lefty proteins (human Lefty A and B) are secreted glycoproteins, but their mode of secretion and the significance of their "glycan" moiety remain mostly unexplored.	Polysaccharides	124-130	left-right determination factor 2	Homo sapiens	22-35
27581986-0	2016	Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site.	Polysaccharides	79-85	CD4 molecule	Homo sapiens	107-110
27581986-10	2016	These glycan-free V5 loops are unusual holes in the glycan shield that may have been necessary for initiating this N276 glycan-dependent CD4 binding site B-cell lineage.	Polysaccharides	6-12	CD4 molecule	Homo sapiens	137-140
27581986-10	2016	These glycan-free V5 loops are unusual holes in the glycan shield that may have been necessary for initiating this N276 glycan-dependent CD4 binding site B-cell lineage.	Polysaccharides	52-58	CD4 molecule	Homo sapiens	137-140
27581986-10	2016	These glycan-free V5 loops are unusual holes in the glycan shield that may have been necessary for initiating this N276 glycan-dependent CD4 binding site B-cell lineage.	Polysaccharides	52-58	CD4 molecule	Homo sapiens	137-140
27581986-14	2016	In this study, we isolate a narrowly neutralizing N276 glycan-dependent antibody and use X-ray crystallography and viral deep sequencing to describe how gp120 lacking glycans in V5 might have elicited these early glycan-dependent CD4 binding site antibodies.	Polysaccharides	167-174	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	153-158
27581986-14	2016	In this study, we isolate a narrowly neutralizing N276 glycan-dependent antibody and use X-ray crystallography and viral deep sequencing to describe how gp120 lacking glycans in V5 might have elicited these early glycan-dependent CD4 binding site antibodies.	Polysaccharides	55-61	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	153-158
27581986-14	2016	In this study, we isolate a narrowly neutralizing N276 glycan-dependent antibody and use X-ray crystallography and viral deep sequencing to describe how gp120 lacking glycans in V5 might have elicited these early glycan-dependent CD4 binding site antibodies.	Polysaccharides	55-61	CD4 molecule	Homo sapiens	230-233
27581986-15	2016	These data highlight how glycan holes can play a role in the elicitation of B-cell lineages targeting the CD4 binding site.	Polysaccharides	25-31	CD4 molecule	Homo sapiens	106-109
27666322-0	2016	Polysaccharide isolated from the liquid culture broth of Inonotus obliquus suppresses invasion of B16-F10 melanoma cells via AKT/NF-kappaB signaling pathway.	Polysaccharides	0-14	thymoma viral proto-oncogene 1	Mus musculus	125-128
27783665-12	2016	Among the tested SG, beta-1,3-glucan sulfates with a Mr &lt;= 10 000 were identified as most promising lead candidates for the development of a glycan-based C1-INH amplifier.	Polysaccharides	144-150	serpin family G member 1	Homo sapiens	157-163
27783694-2	2016	Sialidase (EC 3.2.1.18), which has 4 isozymes including Neu1, Neu2, Neu3 and Neu4, regulates the sialylation level of glycans by removing sialic acid from sialylglycoconjugate.	Polysaccharides	118-125	neuraminidase 1	Rattus norvegicus	56-60
27783694-2	2016	Sialidase (EC 3.2.1.18), which has 4 isozymes including Neu1, Neu2, Neu3 and Neu4, regulates the sialylation level of glycans by removing sialic acid from sialylglycoconjugate.	Polysaccharides	118-125	neuraminidase 2	Rattus norvegicus	62-66
27783694-2	2016	Sialidase (EC 3.2.1.18), which has 4 isozymes including Neu1, Neu2, Neu3 and Neu4, regulates the sialylation level of glycans by removing sialic acid from sialylglycoconjugate.	Polysaccharides	118-125	neuraminidase 3	Rattus norvegicus	68-72
27783694-2	2016	Sialidase (EC 3.2.1.18), which has 4 isozymes including Neu1, Neu2, Neu3 and Neu4, regulates the sialylation level of glycans by removing sialic acid from sialylglycoconjugate.	Polysaccharides	118-125	neuraminidase 4	Rattus norvegicus	77-81
27474578-3	2016	Four water-soluble polysaccharides named as BP1-1, BP1-2, BP1-3 and BP1-4, with molecular weight of 35.8, 32.4, 30.1 and 27.7kDa, were purified by DEAE Sepharose and Superdex 200 chromatography.	Polysaccharides	19-34	BP11	Homo sapiens	44-49
27474578-3	2016	Four water-soluble polysaccharides named as BP1-1, BP1-2, BP1-3 and BP1-4, with molecular weight of 35.8, 32.4, 30.1 and 27.7kDa, were purified by DEAE Sepharose and Superdex 200 chromatography.	Polysaccharides	19-34	BP12	Homo sapiens	51-56
27474576-4	2016	Two homogeneous polysaccharides, EAP-1a and EAP-1b with molecular weights of 8.70kDa and 4.39kDa respectively, were prepared by DEAE-52 cellulose and Sephadex G-100 columns and characterized by HPLC, HPGPC, and FT-IR.	Polysaccharides	16-31	glutamyl aminopeptidase	Mus musculus	33-36
27474578-3	2016	Four water-soluble polysaccharides named as BP1-1, BP1-2, BP1-3 and BP1-4, with molecular weight of 35.8, 32.4, 30.1 and 27.7kDa, were purified by DEAE Sepharose and Superdex 200 chromatography.	Polysaccharides	19-34	BP13	Homo sapiens	58-63
27474576-4	2016	Two homogeneous polysaccharides, EAP-1a and EAP-1b with molecular weights of 8.70kDa and 4.39kDa respectively, were prepared by DEAE-52 cellulose and Sephadex G-100 columns and characterized by HPLC, HPGPC, and FT-IR.	Polysaccharides	16-31	glutamyl aminopeptidase	Mus musculus	44-47
27474576-5	2016	Three polysaccharides (EAP, EAP-1a and EAP-1b) could stimulate macrophages to release NO and enhance phagocytic activities of RAW 264.7 cells in dose-dependent manner.	Polysaccharides	6-21	glutamyl aminopeptidase	Mus musculus	23-26
27474651-0	2016	A polysaccharide from Huaier induced apoptosis in MCF-7 breast cancer cells via down-regulation of MTDH protein.	Polysaccharides	2-16	metadherin	Homo sapiens	99-103
27474578-3	2016	Four water-soluble polysaccharides named as BP1-1, BP1-2, BP1-3 and BP1-4, with molecular weight of 35.8, 32.4, 30.1 and 27.7kDa, were purified by DEAE Sepharose and Superdex 200 chromatography.	Polysaccharides	19-34	BP14	Homo sapiens	68-73
27474679-9	2016	The present findings suggest ATO to be a potent inhibitor of both proliferative and exudative phases of inflammation possibly mediated by the sulphated polysaccharides which might inhibit the action of COX-2 enzyme analogous to dexamethasone.	Polysaccharides	152-167	cox2	Turbinaria ornata	202-207
27474576-5	2016	Three polysaccharides (EAP, EAP-1a and EAP-1b) could stimulate macrophages to release NO and enhance phagocytic activities of RAW 264.7 cells in dose-dependent manner.	Polysaccharides	6-21	glutamyl aminopeptidase	Mus musculus	28-31
27474576-5	2016	Three polysaccharides (EAP, EAP-1a and EAP-1b) could stimulate macrophages to release NO and enhance phagocytic activities of RAW 264.7 cells in dose-dependent manner.	Polysaccharides	6-21	glutamyl aminopeptidase	Mus musculus	28-31
27762591-7	2016	We believe that this FGF-2-presenting polysaccharide film may serve as a biofunctional surface coating for biologically-related applications.	Polysaccharides	38-52	fibroblast growth factor 2	Homo sapiens	21-26
27764122-5	2016	AGA to seven glycans that significantly (P&lt;0.05) differentiated between HGSOC and control were identified: AGA to top candidates SiaTn and 6-OSulfo-TF (both IgM) differentiated comparably to CA125.	Polysaccharides	13-20	mucin 16, cell surface associated	Homo sapiens	194-199
27716795-7	2016	Simulations performed in the context of the Env trimer also indicated that glycosylation reduces flexibility of the V1V2 region, and provided insight into glycan-glycan interactions in this region.	Polysaccharides	162-168	endogenous retrovirus group W member 1, envelope	Homo sapiens	44-47
27653471-11	2016	In addition, certain unique glycan determinants such as bisecting beta1,4-GlcNAcylation and alpha2,3-sialylation, identified in the metastatic (LIM1215) and aggressive (LIM2405) CRC cell lines, respectively, were shown to be associated with epidermal growth factor receptor (EGFR) expression status.	Polysaccharides	28-34	epidermal growth factor receptor	Homo sapiens	241-273
27653471-11	2016	In addition, certain unique glycan determinants such as bisecting beta1,4-GlcNAcylation and alpha2,3-sialylation, identified in the metastatic (LIM1215) and aggressive (LIM2405) CRC cell lines, respectively, were shown to be associated with epidermal growth factor receptor (EGFR) expression status.	Polysaccharides	28-34	epidermal growth factor receptor	Homo sapiens	275-279
27554083-7	2016	We further demonstrate that these glycans presented at N1515 and N1574 also play a critical role in protecting VWF against macrophage binding and clearance.	Polysaccharides	34-41	von Willebrand factor	Homo sapiens	111-114
27662763-1	2016	In this study, a ZIC-HILIC-MS methodology for the analysis of N-glycan isomers was optimized to obtain greater detection sensitivity and thus identify more glycan structures in hAGP.	Polysaccharides	64-70	Zic family member 1	Homo sapiens	17-20
27662763-5	2016	Bi-, tri- and tetraantennary glycan isomers with different terminal sialic acid linkages to galactose (alpha2-3 or alpha2-6) were assigned, and the potential of this technique for the structural characterization of isobaric isomers was therefore demonstrated.	Polysaccharides	29-35	immunoglobulin binding protein 1	Homo sapiens	115-123
27662763-6	2016	Furthermore, fucose linkage isomers of hAGP glycans were also characterized using this isotope-labelling approach in combination with alpha1-3,4 fucosidase and beta1-4 galactosidase digestion.	Polysaccharides	44-51	adrenoceptor alpha 1D	Homo sapiens	134-142
27662763-7	2016	alpha1-3 antennary fucoses and alpha1-6 core fucosylation were detected in hAGP fucosylated glycans.	Polysaccharides	92-99	adrenoceptor alpha 1D	Homo sapiens	0-8
27662763-7	2016	alpha1-3 antennary fucoses and alpha1-6 core fucosylation were detected in hAGP fucosylated glycans.	Polysaccharides	92-99	adrenoceptor alpha 1D	Homo sapiens	31-39
27716795-7	2016	Simulations performed in the context of the Env trimer also indicated that glycosylation reduces flexibility of the V1V2 region, and provided insight into glycan-glycan interactions in this region.	Polysaccharides	155-161	endogenous retrovirus group W member 1, envelope	Homo sapiens	44-47
27550933-0	2016	Polysaccharide Capsule Composition of Pneumococcal Serotype 19A Subtypes Is Unaltered among Subtypes and Independent of the Nutritional Environment.	Polysaccharides	0-14	SLAM family member 7	Homo sapiens	60-63
27754373-4	2016	We review here what is known about the role of specific cancer-associated glycans on MUC1 in protein-protein interactions and intracellular signaling in cancer cells and in their adhesion to each other and the tumor stroma.	Polysaccharides	74-81	mucin 1, cell surface associated	Homo sapiens	85-89
27754373-6	2016	Through multiple types of short glycans simultaneously present in tumors, MUC1 acquires multiple oncogenic properties that control tumor development, progression, and metastasis at different steps of the process of carcinogenesis.	Polysaccharides	32-39	mucin 1, cell surface associated	Homo sapiens	74-78
27102284-4	2016	The features of these extracellular FNGs are quite distinct from the cytosolic FNGs, as they are Gn2-type glycans, bearing an N,N"-diacetylchitobiose unit at their reducing termini, while the cytosolic FNGs are predominantly Gn1-type, with a single GlcNAc at their reducing termini.	Polysaccharides	106-113	glycogenin 2	Homo sapiens	97-100
27582506-5	2016	Here, we show that both of these sites can be modified with an N-glycan and that the glycan at position N747 modulates agonist-sensitivity of TRPA1 in vitro Additionally, we found that N-glycosylation also modulates cooperative effects of temperature and the agonist cinnamaldehyde on TRPA1 channel activation.	Polysaccharides	65-71	transient receptor potential cation channel subfamily A member 1	Homo sapiens	142-147
27792989-3	2016	The advances in tools and technologies to chemically synthesize and structurally characterize glycans and glycan-GBP interactions have offered several insights into the role of glycan-GBP interactions in viral pathogenesis and have presented opportunities to target these interactions for novel antiviral therapeutic or vaccine strategies.	Polysaccharides	94-101	transmembrane protein 132A	Homo sapiens	184-187
27792989-4	2016	This review covers aspects of role of host cell surface glycan receptors and viral surface glycans in viral pathogenesis and offers perspectives on how to employ various analytical tools to target glycan-GBP interactions.	Polysaccharides	91-98	transmembrane protein 132A	Homo sapiens	204-207
27563008-6	2016	In addition, galectin-mediated erythrocyte agglutination assays using lactose and larger complex polysaccharides as inhibitors showed the structural differences between Gal-1 and Gal-2.	Polysaccharides	97-112	galectin 1	Homo sapiens	169-174
27563008-6	2016	In addition, galectin-mediated erythrocyte agglutination assays using lactose and larger complex polysaccharides as inhibitors showed the structural differences between Gal-1 and Gal-2.	Polysaccharides	97-112	galectin 2	Homo sapiens	179-184
27567024-6	2016	Our findings reveal that the glycan modification is a key regulator of EC-SOD secretion and contributes to the understanding of the roles of glycans in EC-SOD-related diseases.	Polysaccharides	29-35	superoxide dismutase 3	Homo sapiens	71-77
27567024-6	2016	Our findings reveal that the glycan modification is a key regulator of EC-SOD secretion and contributes to the understanding of the roles of glycans in EC-SOD-related diseases.	Polysaccharides	141-148	superoxide dismutase 3	Homo sapiens	71-77
27287437-4	2016	Both Gal-8 isoforms bind to cells of the myeloma lines Gal-8+ MOLP-8 and Gal-8- LP-1 in a glycan-inhibitable manner.	Polysaccharides	90-96	galectin 8	Homo sapiens	5-10
27129881-1	2016	Four Astragalus polysaccharides (APS1-APS4) were isolated from the water extract of Radix Astragali and purified through ethanol precipitation with 20 %, 40 %, 60 % and 80 % ethanol, respectively.	Polysaccharides	16-31	nudix hydrolase 11	Homo sapiens	33-37
27287437-4	2016	Both Gal-8 isoforms bind to cells of the myeloma lines Gal-8+ MOLP-8 and Gal-8- LP-1 in a glycan-inhibitable manner.	Polysaccharides	90-96	galectin 8	Homo sapiens	55-60
27287437-4	2016	Both Gal-8 isoforms bind to cells of the myeloma lines Gal-8+ MOLP-8 and Gal-8- LP-1 in a glycan-inhibitable manner.	Polysaccharides	90-96	galectin 8	Homo sapiens	55-60
27351940-5	2016	Altered glycan structures in the hinge region of the heavy chains of IgA1 molecules act as auto-antigens, potentially triggering the production of glycan-specific autoantibodies.	Polysaccharides	8-14	immunoglobulin heavy constant alpha 1	Homo sapiens	69-73
27594322-1	2016	Protein-bound polysaccharides (PBP) isolated from Coriolus versicolor (CV) are classified as biological response modifiers capable of exhibiting various biological activities, such as anti-tumour and immunopotentiating activity.	Polysaccharides	14-29	phosphatidylethanolamine binding protein 1	Rattus norvegicus	31-34
27351940-5	2016	Altered glycan structures in the hinge region of the heavy chains of IgA1 molecules act as auto-antigens, potentially triggering the production of glycan-specific autoantibodies.	Polysaccharides	147-153	immunoglobulin heavy constant alpha 1	Homo sapiens	69-73
27475664-5	2016	AOPPs stimulation induced ROS generation and NF-kappa B p65 phosphorylation, which could be inhibited by soluble receptor for advanced glycan end products (sRAGE), NADPH oxidase inhibitor (apocynin), ROS scavenger (N-acetyl-cysteine, NAC).	Polysaccharides	135-141	nuclear factor kappa B subunit 1	Homo sapiens	45-55
27328612-2	2016	Here, we quantitatively assessed and compared binding of pectin-derived polysaccharides to galectin-3 (Gal-3) using five methods: surface plasmon resonance (SPR), bio-layer interferometry (BLI), fluorescence polarization (FP), competitive fluorescence-linked immunosorbance (cFLISA), and the well-known cell-based hemagglutination assay (G3H).	Polysaccharides	72-87	galectin 3	Homo sapiens	91-101
27328612-2	2016	Here, we quantitatively assessed and compared binding of pectin-derived polysaccharides to galectin-3 (Gal-3) using five methods: surface plasmon resonance (SPR), bio-layer interferometry (BLI), fluorescence polarization (FP), competitive fluorescence-linked immunosorbance (cFLISA), and the well-known cell-based hemagglutination assay (G3H).	Polysaccharides	72-87	galectin 3	Homo sapiens	103-108
27370747-1	2016	A homogeneous polysaccharide (PPB) was purified from fruiting bodies of Phellinus baumii.	Polysaccharides	14-28	histatin 1	Homo sapiens	30-33
27475664-5	2016	AOPPs stimulation induced ROS generation and NF-kappa B p65 phosphorylation, which could be inhibited by soluble receptor for advanced glycan end products (sRAGE), NADPH oxidase inhibitor (apocynin), ROS scavenger (N-acetyl-cysteine, NAC).	Polysaccharides	135-141	RELA proto-oncogene, NF-kB subunit	Homo sapiens	56-59
27924120-8	2016	GO analysis showed involvement of GH 38 and ATXR 6 in glycan and lysine degradation pathways.	Polysaccharides	54-60	TRITHORAX-RELATED PROTEIN 6	Arabidopsis thaliana	44-50
27633119-0	2016	A novel polysaccharide derived from algae extract induces apoptosis and cell cycle arrest in human gastric carcinoma MKN45 cells via ROS/JNK signaling pathway.	Polysaccharides	8-22	mitogen-activated protein kinase 8	Homo sapiens	137-140
27148766-8	2016	LpMab-13 recognized glycan-deficient hPDPN in flow cytometry, indicating that the interaction between LpMab-13 and hPDPN is independent of its glycosylation.	Polysaccharides	20-26	podoplanin	Homo sapiens	37-42
27526028-0	2016	Structural basis of laminin binding to the LARGE glycans on dystroglycan.	Polysaccharides	49-56	dystroglycan 1	Homo sapiens	60-72
27526028-3	2016	Like-acetylglucosaminyltransferase (LARGE) synthesizes the matrix-binding heteropolysaccharide [-glucuronic acid-beta1,3-xylose-alpha1,3-]n. Using a dual exoglycosidase digestion, we confirm that this polysaccharide is present on native alpha-DG from skeletal muscle.	Polysaccharides	80-94	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	113-120
27526028-3	2016	Like-acetylglucosaminyltransferase (LARGE) synthesizes the matrix-binding heteropolysaccharide [-glucuronic acid-beta1,3-xylose-alpha1,3-]n. Using a dual exoglycosidase digestion, we confirm that this polysaccharide is present on native alpha-DG from skeletal muscle.	Polysaccharides	80-94	adrenoceptor alpha 1D	Homo sapiens	128-136
27633119-5	2016	Furthermore, we observed that the generation of reactive oxygen species (ROS) and the phosphorylation of Jun N-terminal kinase (JNK), p53, caspase-9 and -3 were induced in the polysaccharide-treated MKN45 cells.	Polysaccharides	176-190	mitogen-activated protein kinase 8	Homo sapiens	105-126
27633119-5	2016	Furthermore, we observed that the generation of reactive oxygen species (ROS) and the phosphorylation of Jun N-terminal kinase (JNK), p53, caspase-9 and -3 were induced in the polysaccharide-treated MKN45 cells.	Polysaccharides	176-190	mitogen-activated protein kinase 8	Homo sapiens	128-131
27633119-5	2016	Furthermore, we observed that the generation of reactive oxygen species (ROS) and the phosphorylation of Jun N-terminal kinase (JNK), p53, caspase-9 and -3 were induced in the polysaccharide-treated MKN45 cells.	Polysaccharides	176-190	tumor protein p53	Homo sapiens	134-137
27633119-5	2016	Furthermore, we observed that the generation of reactive oxygen species (ROS) and the phosphorylation of Jun N-terminal kinase (JNK), p53, caspase-9 and -3 were induced in the polysaccharide-treated MKN45 cells.	Polysaccharides	176-190	caspase 9	Homo sapiens	139-155
27633119-7	2016	Finally, we found that pretreatment with NAC prevented the JNK, p53, caspase-9 and -3 protein phosphorylation induced by the polysaccharide, however, pretreatment with SP600125 did not affect the generation of ROS, suggesting that ROS is upstream of JNK.	Polysaccharides	125-139	mitogen-activated protein kinase 8	Homo sapiens	59-62
27633119-7	2016	Finally, we found that pretreatment with NAC prevented the JNK, p53, caspase-9 and -3 protein phosphorylation induced by the polysaccharide, however, pretreatment with SP600125 did not affect the generation of ROS, suggesting that ROS is upstream of JNK.	Polysaccharides	125-139	tumor protein p53	Homo sapiens	64-67
27633119-7	2016	Finally, we found that pretreatment with NAC prevented the JNK, p53, caspase-9 and -3 protein phosphorylation induced by the polysaccharide, however, pretreatment with SP600125 did not affect the generation of ROS, suggesting that ROS is upstream of JNK.	Polysaccharides	125-139	caspase 9	Homo sapiens	69-85
27633119-7	2016	Finally, we found that pretreatment with NAC prevented the JNK, p53, caspase-9 and -3 protein phosphorylation induced by the polysaccharide, however, pretreatment with SP600125 did not affect the generation of ROS, suggesting that ROS is upstream of JNK.	Polysaccharides	125-139	mitogen-activated protein kinase 8	Homo sapiens	250-253
27633119-8	2016	Taken together, the novel polysaccharide induced cancer cell apoptosis and arrested cell cycle via ROS/JNK signaling pathway.	Polysaccharides	26-40	mitogen-activated protein kinase 8	Homo sapiens	103-106
27617431-2	2016	Variability in high-mannose and complex-type Env glycoforms leads to heterogeneity that usually precludes visualization of the native glycan shield.	Polysaccharides	134-140	endogenous retrovirus group K member 20	Homo sapiens	45-48
27617431-3	2016	We present 3.5-A- and 3.9-A-resolution crystal structures of the HIV-1 Env trimer with fully processed and native glycosylation, revealing a glycan shield of high-mannose and complex-type N-glycans, which we used to define complete epitopes of two bNAbs.	Polysaccharides	141-147	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	71-74
27489265-0	2016	Changes in Structure and Antigenicity of HIV-1 Env Trimers Resulting from Removal of a Conserved CD4 Binding Site-Proximal Glycan.	Polysaccharides	123-129	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	47-50
27686492-4	2016	The functional role of tumor-associated glycans (Tn, sTn, T, and sLea/x) is dependent on the interaction with lectins.	Polysaccharides	40-47	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	53-56
27489265-0	2016	Changes in Structure and Antigenicity of HIV-1 Env Trimers Resulting from Removal of a Conserved CD4 Binding Site-Proximal Glycan.	Polysaccharides	123-129	CD4 molecule	Homo sapiens	97-100
27489265-3	2016	Previous studies have shown that the removal of a particular conserved glycan at N197 increases the neutralization sensitivity of the virus to antibodies targeting the CD4 binding site (CD4bs), making it a site of significant interest from the perspective of vaccine design.	Polysaccharides	71-77	CD4 molecule	Homo sapiens	168-171
27489265-8	2016	Structural modeling of the glycan chains suggests that the spatial occupancy of the N197 glycan leads to steric clashes with CD4bs antibodies in the Env trimer but not monomeric gp120.	Polysaccharides	27-33	CD4 molecule	Homo sapiens	125-128
27489265-8	2016	Structural modeling of the glycan chains suggests that the spatial occupancy of the N197 glycan leads to steric clashes with CD4bs antibodies in the Env trimer but not monomeric gp120.	Polysaccharides	27-33	endogenous retrovirus group K member 20	Homo sapiens	149-152
27489265-8	2016	Structural modeling of the glycan chains suggests that the spatial occupancy of the N197 glycan leads to steric clashes with CD4bs antibodies in the Env trimer but not monomeric gp120.	Polysaccharides	89-95	CD4 molecule	Homo sapiens	125-128
27489265-8	2016	Structural modeling of the glycan chains suggests that the spatial occupancy of the N197 glycan leads to steric clashes with CD4bs antibodies in the Env trimer but not monomeric gp120.	Polysaccharides	89-95	endogenous retrovirus group K member 20	Homo sapiens	149-152
27489265-9	2016	Our results indicate that the removal of the N197 glycan enhances the exposure of relevant bNAb epitopes on Env with a minimal impact on the overall trimeric structure.	Polysaccharides	50-56	endogenous retrovirus group K member 20	Homo sapiens	108-111
27608266-1	2016	Aiming to achieve the modification to soy protein isolate (SPI) by soy soluble polysaccharides (SSPS), electrically driven complex systems were first established in the environment of pH 3.0, and then reconstituted SPI particles with different SPI-SSPS ratios were obtained under freeze-drying process.	Polysaccharides	79-94	chromogranin A	Homo sapiens	59-62
27261754-0	2016	The physico-chemical properties of chia seed polysaccharide and its microgel dispersion rheology.	Polysaccharides	45-59	chitinase acidic	Homo sapiens	35-39
27261754-1	2016	The polysaccharide gel layer surrounding hydrated chia seeds was extracted using water and isolated by ethanol precipitation.	Polysaccharides	4-18	chitinase acidic	Homo sapiens	50-54
27356186-0	2016	Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition.	Polysaccharides	113-119	lectin, galactose binding, soluble 3	Mus musculus	0-10
27882199-3	2016	Through strategic selection of the mammalian expression host, we were able to introduce azide-functionalized glycans onto a homogeneously glycosylated anti-EphA2 monoclonal antibody in one step.	Polysaccharides	109-116	EPH receptor A2	Homo sapiens	156-161
27621420-4	2016	Binding of PTX3 promoted homeostatic production of IgM and class-switched IgG antibodies to microbial capsular polysaccharides, which decreased in PTX3-deficient mice and humans.	Polysaccharides	111-126	pentraxin related gene	Mus musculus	11-15
27356186-1	2016	Discovery of glycan-competitive galectin-3-binding compounds that attenuate lung fibrosis in a murine model and that block intracellular galectin-3 accumulation at damaged vesicles, hence revealing galectin-3-glycan interactions involved in fibrosis progression and in intracellular galectin-3 activities, is reported.	Polysaccharides	13-19	lectin, galactose binding, soluble 3	Mus musculus	32-42
27356186-1	2016	Discovery of glycan-competitive galectin-3-binding compounds that attenuate lung fibrosis in a murine model and that block intracellular galectin-3 accumulation at damaged vesicles, hence revealing galectin-3-glycan interactions involved in fibrosis progression and in intracellular galectin-3 activities, is reported.	Polysaccharides	13-19	lectin, galactose binding, soluble 3	Mus musculus	137-147
27356186-1	2016	Discovery of glycan-competitive galectin-3-binding compounds that attenuate lung fibrosis in a murine model and that block intracellular galectin-3 accumulation at damaged vesicles, hence revealing galectin-3-glycan interactions involved in fibrosis progression and in intracellular galectin-3 activities, is reported.	Polysaccharides	13-19	lectin, galactose binding, soluble 3	Mus musculus	137-147
27356186-1	2016	Discovery of glycan-competitive galectin-3-binding compounds that attenuate lung fibrosis in a murine model and that block intracellular galectin-3 accumulation at damaged vesicles, hence revealing galectin-3-glycan interactions involved in fibrosis progression and in intracellular galectin-3 activities, is reported.	Polysaccharides	13-19	lectin, galactose binding, soluble 3	Mus musculus	137-147
27649122-2	2016	A novel homogeneous polysaccharide, named as H-1-2, was isolated from the semi-refined polysaccharide.	Polysaccharides	20-34	histocompatibility 1	Mus musculus	45-50
27444351-3	2016	PURPOSE: To investigate the effect of MHP-1, a newly isolated polysaccharide from Mortierella hepialid (the asexual structure of C. sinensis), on breast cancer metastasis.	Polysaccharides	62-76	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	38-43
27711440-3	2016	The bioactivity of the two different outer surface sugar units was evaluated by defining glycan relative binding affinities to human galectins 1 and 3.	Polysaccharides	89-95	galectin 1	Homo sapiens	133-150
27604319-2	2016	Gp120 has remarkably high levels of N-linked glycosylation and there is considerable evidence that this "glycan shield" can help protect the virus from antibody-mediated neutralization.	Polysaccharides	105-111	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	0-5
27258397-0	2016	Probability of N332 glycan occupancy on HIV-1 gp120 modulates sensitivity to broadly neutralizing antibodies.	Polysaccharides	20-26	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	46-51
27258397-1	2016	OBJECTIVE(S): The glycan shield of the HIV-1 envelope glycoprotein complex (Env), in particular the glycan at position 332 in gp120, is frequently targeted by broadly neutralizing antibodies (bNAbs) isolated from HIV-1-infected individuals.	Polysaccharides	18-24	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	76-79
27258397-1	2016	OBJECTIVE(S): The glycan shield of the HIV-1 envelope glycoprotein complex (Env), in particular the glycan at position 332 in gp120, is frequently targeted by broadly neutralizing antibodies (bNAbs) isolated from HIV-1-infected individuals.	Polysaccharides	18-24	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	126-131
27258397-1	2016	OBJECTIVE(S): The glycan shield of the HIV-1 envelope glycoprotein complex (Env), in particular the glycan at position 332 in gp120, is frequently targeted by broadly neutralizing antibodies (bNAbs) isolated from HIV-1-infected individuals.	Polysaccharides	100-106	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	76-79
27258397-1	2016	OBJECTIVE(S): The glycan shield of the HIV-1 envelope glycoprotein complex (Env), in particular the glycan at position 332 in gp120, is frequently targeted by broadly neutralizing antibodies (bNAbs) isolated from HIV-1-infected individuals.	Polysaccharides	100-106	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	126-131
27500311-3	2016	One inhibitor displayed efficacy in a murine model of bleomycin-induced lung fibrosis similar to that of a known nonselective galectin-1/galectin-3 inhibitor, which strongly suggests that blocking galectin-3 glycan recognition is an important antifibrotic drug target.	Polysaccharides	208-214	lectin, galactose binding, soluble 3	Mus musculus	197-207
27649122-2	2016	A novel homogeneous polysaccharide, named as H-1-2, was isolated from the semi-refined polysaccharide.	Polysaccharides	87-101	histocompatibility 1	Mus musculus	45-50
27367911-7	2016	UT-A1 is glycosylated with various glycan moieties in animal models of diabetes mellitus.	Polysaccharides	35-41	solute carrier family 14 (urea transporter), member 2	Mus musculus	0-5
27427418-1	2016	Polysaccharides from Saccharomyces cerevisiae can induce arthritis, ileitis, and interstitial pneumonitis in BALB/c ZAP70 (W163C)-mutant (SKG) mice via T helper 17-cell-dependent pathways.	Polysaccharides	0-15	zeta-chain (TCR) associated protein kinase	Mus musculus	116-121
27193255-2	2016	Mannanase is an important enzyme that hydrolyses mannose-containing polysaccharides which are abundant in plants.	Polysaccharides	68-83	mannosidase beta	Homo sapiens	0-9
26874335-0	2016	High-performance liquid chromatographic enantioseparation of fluorinated cyclic beta(3) -amino acid derivatives on polysaccharide-based chiral stationary phases.	Polysaccharides	115-129	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	80-87
27160519-6	2016	Additionally, the DOE data were used to develop models to predict ADCC, CDC, and FcgammaRIIIa binding of a given configuration of the three glycan species for this IgG1 molecule.	Polysaccharides	140-146	Fc gamma receptor IIIa	Homo sapiens	81-93
27262461-1	2016	The protective effects of extracellular and intracellular polysaccharides from Hericium erinaceus SG-02 on the CCl4-induced hepatic injury of mice were investigated in this work.	Polysaccharides	58-73	chemokine (C-C motif) ligand 4	Mus musculus	111-115
27146521-3	2016	By truncating these glycans in a myeloid-specific knockout of Mgat2, created using the LyzM-CRE mouse (M-cKO), we previously reported defects in PSA responses in vivo.	Polysaccharides	20-27	mannoside acetylglucosaminyltransferase 2	Mus musculus	62-67
27449907-1	2016	The V1/V2 domain of the HIV-1 envelope protein gp120 possesses two important epitopes: a glycan-dependent epitope recognized by the prototypic broadly neutralizing monoclonal antibody (bN-mAb), PG9, as well as an epitope recognized by non-neutralizing antibodies that has been associated with protection from HIV infection in the RV144 HIV vaccine trial.	Polysaccharides	89-95	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	47-52
27582638-8	2016	The separations of glycans in HILIC are sufficient to permit resolution of isomeric N-glycan structures, such as sialylated N-glycan isomers differing in alpha2-3 and alpha2-6 linkages, while these glycans remain attached to peptides.	Polysaccharides	19-26	immunoglobulin binding protein 1	Homo sapiens	167-175
27466186-9	2016	In combination with dGALT loss, both dGALE and dUGP mutants compromise the synaptomatrix glycan environment that regulates Wnt trans-synaptic signalling that drives 1) presynaptic Futsch/MAP1b microtubule dynamics and 2) postsynaptic Frizzled nuclear import (FNI).	Polysaccharides	89-95	Galactose-1-phosphate uridylyltransferase	Drosophila melanogaster	20-25
27466186-9	2016	In combination with dGALT loss, both dGALE and dUGP mutants compromise the synaptomatrix glycan environment that regulates Wnt trans-synaptic signalling that drives 1) presynaptic Futsch/MAP1b microtubule dynamics and 2) postsynaptic Frizzled nuclear import (FNI).	Polysaccharides	89-95	UDP-galactose 4'-epimerase	Drosophila melanogaster	37-42
27466186-9	2016	In combination with dGALT loss, both dGALE and dUGP mutants compromise the synaptomatrix glycan environment that regulates Wnt trans-synaptic signalling that drives 1) presynaptic Futsch/MAP1b microtubule dynamics and 2) postsynaptic Frizzled nuclear import (FNI).	Polysaccharides	89-95	UDP-glucose pyrophosphorylase	Drosophila melanogaster	47-51
27466186-9	2016	In combination with dGALT loss, both dGALE and dUGP mutants compromise the synaptomatrix glycan environment that regulates Wnt trans-synaptic signalling that drives 1) presynaptic Futsch/MAP1b microtubule dynamics and 2) postsynaptic Frizzled nuclear import (FNI).	Polysaccharides	89-95	Wnt oncogene analog 5	Drosophila melanogaster	123-126
27466186-9	2016	In combination with dGALT loss, both dGALE and dUGP mutants compromise the synaptomatrix glycan environment that regulates Wnt trans-synaptic signalling that drives 1) presynaptic Futsch/MAP1b microtubule dynamics and 2) postsynaptic Frizzled nuclear import (FNI).	Polysaccharides	89-95	futsch	Drosophila melanogaster	180-186
27466186-9	2016	In combination with dGALT loss, both dGALE and dUGP mutants compromise the synaptomatrix glycan environment that regulates Wnt trans-synaptic signalling that drives 1) presynaptic Futsch/MAP1b microtubule dynamics and 2) postsynaptic Frizzled nuclear import (FNI).	Polysaccharides	89-95	futsch	Drosophila melanogaster	187-192
26944415-0	2016	Dietary Non-digestible Polysaccharides Ameliorate Intestinal Epithelial Barrier Dysfunction in IL-10 Knockout Mice.	Polysaccharides	23-38	interleukin 10	Mus musculus	95-100
27350640-3	2016	Binding and affinity of trimeric human SP-D to Hep in distinct LPS inner core glycans differing in linkages and adjacent residues was elucidated using glycan array and surface plasmon resonance measurements that were compared to in silico interaction studies.	Polysaccharides	78-85	surfactant protein D	Homo sapiens	39-43
27350640-3	2016	Binding and affinity of trimeric human SP-D to Hep in distinct LPS inner core glycans differing in linkages and adjacent residues was elucidated using glycan array and surface plasmon resonance measurements that were compared to in silico interaction studies.	Polysaccharides	78-85	DNL-type zinc finger	Homo sapiens	47-50
27350640-3	2016	Binding and affinity of trimeric human SP-D to Hep in distinct LPS inner core glycans differing in linkages and adjacent residues was elucidated using glycan array and surface plasmon resonance measurements that were compared to in silico interaction studies.	Polysaccharides	78-84	surfactant protein D	Homo sapiens	39-43
27350640-3	2016	Binding and affinity of trimeric human SP-D to Hep in distinct LPS inner core glycans differing in linkages and adjacent residues was elucidated using glycan array and surface plasmon resonance measurements that were compared to in silico interaction studies.	Polysaccharides	78-84	DNL-type zinc finger	Homo sapiens	47-50
27350640-4	2016	The combination of in vitro assays using defined glycans and molecular docking and dynamic simulation approaches provides insights into the interaction of trimeric SP-D with those glycan ligands.	Polysaccharides	49-56	surfactant protein D	Homo sapiens	164-168
27350640-4	2016	The combination of in vitro assays using defined glycans and molecular docking and dynamic simulation approaches provides insights into the interaction of trimeric SP-D with those glycan ligands.	Polysaccharides	49-55	surfactant protein D	Homo sapiens	164-168
27493216-8	2016	On the basis of our findings, we propose a mechanism for the deficiency in postphosphoryl modification of the glycan observed in POMGnT1-KO mice and MEB patients.	Polysaccharides	110-116	protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase	Mus musculus	129-136
29513410-4	2016	With peroral introduction, the initial polysaccharide (50 mg/kg) and its derivative inhibited the development of chemically induced inflammation of experimental animals" large intestines, which was manifested as a decrease in the affected area and the degree of damage to the large intestine wall, as well as a two-fold reduction of myeloperoxidase activity.	Polysaccharides	39-53	myeloperoxidase	Mus musculus	333-348
29513471-1	2016	The study demonstrated that chitooligosaccharides with a molecular weight of 5-10 kDa and a degree of acetylation of 65% exhibited an auxin-like effect in wheat plants and also played an important role in regulating the activity of polysaccharide (chitin)-specific anion isoenzymes of peroxidase oxidizing indole acetic acid.	Polysaccharides	232-246	peroxidase-like	Triticum aestivum	285-295
27555309-2	2016	We identified the target molecules of BSAP-sensitive cells and showed that each BSAP targets a different class of surface molecule: BSAP-1 targets an outer membrane protein of sensitive B. fragilis strains, and BSAP-2 targets the O-antigen glycan of lipopolysaccharide (LPS) of sensitive B. uniformis strains.	Polysaccharides	240-246	paired box 5	Homo sapiens	38-42
27555309-2	2016	We identified the target molecules of BSAP-sensitive cells and showed that each BSAP targets a different class of surface molecule: BSAP-1 targets an outer membrane protein of sensitive B. fragilis strains, and BSAP-2 targets the O-antigen glycan of lipopolysaccharide (LPS) of sensitive B. uniformis strains.	Polysaccharides	240-246	paired box 5	Homo sapiens	80-84
27555309-2	2016	We identified the target molecules of BSAP-sensitive cells and showed that each BSAP targets a different class of surface molecule: BSAP-1 targets an outer membrane protein of sensitive B. fragilis strains, and BSAP-2 targets the O-antigen glycan of lipopolysaccharide (LPS) of sensitive B. uniformis strains.	Polysaccharides	240-246	paired box 5	Homo sapiens	80-84
27555309-2	2016	We identified the target molecules of BSAP-sensitive cells and showed that each BSAP targets a different class of surface molecule: BSAP-1 targets an outer membrane protein of sensitive B. fragilis strains, and BSAP-2 targets the O-antigen glycan of lipopolysaccharide (LPS) of sensitive B. uniformis strains.	Polysaccharides	240-246	paired box 5	Homo sapiens	80-84
27358401-6	2016	This binding was inhibited by mannosidase treatment of H. alvei LPS and by mutations in the carbohydrate-binding domain of Dectin-2, demonstrating that H. alvei LPS is a novel glycan ligand of Dectin-2.	Polysaccharides	176-182	C-type lectin domain containing 6A	Homo sapiens	123-131
27358401-6	2016	This binding was inhibited by mannosidase treatment of H. alvei LPS and by mutations in the carbohydrate-binding domain of Dectin-2, demonstrating that H. alvei LPS is a novel glycan ligand of Dectin-2.	Polysaccharides	176-182	C-type lectin domain containing 6A	Homo sapiens	193-201
27096636-1	2016	Immunoglobulin G3 (IgG3) is the predominant IgG subclass elicited in response to polysaccharide antigens in mice.	Polysaccharides	81-95	Immunoglobulin heavy constant gamma 3	Mus musculus	0-17
27096636-1	2016	Immunoglobulin G3 (IgG3) is the predominant IgG subclass elicited in response to polysaccharide antigens in mice.	Polysaccharides	81-95	Immunoglobulin heavy constant gamma 3	Mus musculus	19-23
27224549-0	2016	Isotype switching: Mouse IgG3 constant region drives increased affinity for polysaccharide antigens.	Polysaccharides	76-90	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	25-29
27316967-10	2016	Streptococcus gordonii DL1 has three cell wall-anchored glycoside hydrolases that are predicted to act on host glycans.	Polysaccharides	111-118	Galactose-specific C-type lectin	Drosophila melanogaster	23-26
27316967-12	2016	The results indicate that the growth of S. gordonii DL1 depends to a significant extent on sequential action of these cell surface GHs on N-linked glycans of basic proline-rich salivary glycoproteins, which appears to be an essential first step in salivary glycan foraging.	Polysaccharides	147-153	Galactose-specific C-type lectin	Drosophila melanogaster	52-55
27584569-1	2016	VWF is extensively glycosylated with biantennary core fucosylated glycans.	Polysaccharides	66-73	von Willebrand factor	Homo sapiens	0-3
27584569-3	2016	FVIII is also glycosylated, with a glycan structure similar to that of VWF.	Polysaccharides	35-41	coagulation factor VIII	Homo sapiens	0-5
27576440-1	2016	The glycan supersite centered on N332 in the V3 base of the HIV-1 envelope (Env) is a target for broadly neutralizing antibodies (bnAbs) such as PGT121 and PGT128.	Polysaccharides	4-10	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	76-79
27554324-3	2016	Our previous studies showed the plant-derived natural polysaccharide (Polygonatum sibiricum polysaccharide or PSP) had significant anti-ovariectomy (OVX)-induced osteoporosis effects in vivo, but the mechanisms of PSP"s anti-osteoporosis effect remains unclear.	Polysaccharides	54-68	persephin	Mus musculus	110-113
27554324-3	2016	Our previous studies showed the plant-derived natural polysaccharide (Polygonatum sibiricum polysaccharide or PSP) had significant anti-ovariectomy (OVX)-induced osteoporosis effects in vivo, but the mechanisms of PSP"s anti-osteoporosis effect remains unclear.	Polysaccharides	54-68	persephin	Mus musculus	214-217
27496330-4	2016	Nuclear translocation of Gal-1, in turn, was regulated by discrete cell-surface glycans restricted to the front of the mammary end buds.	Polysaccharides	80-87	galectin 1	Homo sapiens	25-30
27496330-0	2016	Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis.	Polysaccharides	57-63	galectin 1	Homo sapiens	26-36
27496330-2	2016	Here we show that galectin-1 (Gal-1), an endogenous lectin that recognizes glycans bearing N-acetyllactosamine (LacNAc) epitopes, induces branching migration of mammary epithelia in vivo, ex vivo, and in 3D organotypic cultures.	Polysaccharides	75-82	galectin 1	Homo sapiens	18-28
27496330-2	2016	Here we show that galectin-1 (Gal-1), an endogenous lectin that recognizes glycans bearing N-acetyllactosamine (LacNAc) epitopes, induces branching migration of mammary epithelia in vivo, ex vivo, and in 3D organotypic cultures.	Polysaccharides	75-82	galectin 1	Homo sapiens	30-35
27496330-3	2016	Surprisingly, Gal-1"s effects on mammary patterning were independent of its glycan-binding ability and instead required localization within the nuclei of mammary epithelia.	Polysaccharides	76-82	galectin 1	Homo sapiens	14-19
27325697-3	2016	The targeting of PrP(C) to synapses was dependent upon both neuronal cholesterol concentrations and the lipid and glycan composition of its glycosylphosphatidylinositol (GPI) anchor.	Polysaccharides	114-120	prion protein	Mus musculus	17-23
27345664-5	2016	Glycan signaling from the extracellular matrix converges on "master" regulators of autophagy including AMPK and mTORC1, thus impacting their localization, activity, and/or expression.	Polysaccharides	0-6	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	103-107
27345664-5	2016	Glycan signaling from the extracellular matrix converges on "master" regulators of autophagy including AMPK and mTORC1, thus impacting their localization, activity, and/or expression.	Polysaccharides	0-6	CREB regulated transcription coactivator 1	Mus musculus	112-118
26880333-3	2016	The MUC2 glycans are important for selection of the commensal bacteria and act as a nutritional source for the bacteria; this also helps the host to recover some of the energy spent on constantly renewing the protective mucus layer.	Polysaccharides	9-16	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	4-8
27105834-1	2016	Polysialic acid (polySia, PSA) is a unique and functionally important glycan, particularly in vertebrate brains.	Polysaccharides	70-76	aminopeptidase puromycin sensitive	Homo sapiens	26-29
27385218-3	2016	SEP, a polysaccharide isolated from Strongylocentrotus nudus egg, has been reported to display antitumor activity by stimulating immune cells, including NK and T cells, via TLR2 and TLR4.	Polysaccharides	7-21	membrane metalloendopeptidase like 1	Homo sapiens	0-3
26435041-0	2016	Polysaccharides from Acanthopanax senticosus enhances intestinal integrity through inhibiting TLR4/NF-kappaB signaling pathways in lipopolysaccharide-challenged mice.	Polysaccharides	0-15	toll-like receptor 4	Mus musculus	94-98
26435041-0	2016	Polysaccharides from Acanthopanax senticosus enhances intestinal integrity through inhibiting TLR4/NF-kappaB signaling pathways in lipopolysaccharide-challenged mice.	Polysaccharides	0-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
26435041-1	2016	To investigate the role of polysaccharide from Acanthopanax senticosus (ASPS) on lipopolysaccharide (LPS)-induced intestinal injury, mice in three treatments were administrated orally with or without ASPS (300 mg/kg body weight) for 14 days, followed by challenge with LPS or saline.	Polysaccharides	27-41	alveolar soft part sarcoma chromosome region, candidate 1 (human)	Mus musculus	72-76
26721331-0	2016	Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer.	Polysaccharides	55-62	macrophage stimulating 1 receptor	Homo sapiens	80-83
26721331-1	2016	BACKGROUND: Terminal alpha2-3 and alpha2-6 sialylation of glycans precludes further chain elongation, leading to the biosynthesis of cancer relevant epitopes such as sialyl-Lewis X (SLe(X)).	Polysaccharides	58-65	immunoglobulin binding protein 1	Homo sapiens	34-42
26721331-3	2016	METHODS: MKN45 gastric carcinoma cells transfected with the sialyltransferase ST3GAL4 were established as a model overexpressing sialylated terminal glycans.	Polysaccharides	149-156	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	78-85
27459991-13	2016	Co-incubation of Gal-8 with lactose, which blocks galectin-glycan interactions, abrogated both effects.	Polysaccharides	59-65	galectin 8	Homo sapiens	17-22
26804479-2	2016	alpha1,3-FucT from Helicobacter pylori 26695 (FutA) accepts lactose and LacNAc as glycan acceptors and has a very low level of expression in Escherichia coli, and it shows a low catalytic activity for lactose in the large-scale synthesis of 3-FL.	Polysaccharides	82-88	fucosyltransferase 11	Homo sapiens	0-13
27304194-3	2016	As proof of concept, we have analyzed the binding of Gal1, Gal3, and influenza hemagglutinins (HAs) to various glycans and demonstrated that binding partners can be identified with high confidence.	Polysaccharides	111-118	galectin 1	Homo sapiens	53-57
27304194-3	2016	As proof of concept, we have analyzed the binding of Gal1, Gal3, and influenza hemagglutinins (HAs) to various glycans and demonstrated that binding partners can be identified with high confidence.	Polysaccharides	111-118	galectin 3	Homo sapiens	59-63
27345527-1	2016	A polysaccharide fraction, here called POP1, was purified from the leaves of Platycladus orientalis (L.) Franco by water extraction and alcohol precipitation.	Polysaccharides	2-16	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	39-43
27281538-0	2016	Efficient Targeting of Adipose Tissue Macrophages in Obesity with Polysaccharide Nanocarriers.	Polysaccharides	66-80	WD and tetratricopeptide repeats 1	Mus musculus	23-30
27281538-4	2016	Here we report that nanoscale polysaccharides based on biocompatible glucose polymers can efficiently target adipose macrophages in obese mice.	Polysaccharides	30-45	WD and tetratricopeptide repeats 1	Mus musculus	109-116
27142572-8	2016	Purified cell wall polysaccharides of A. nidulans induced a much higher level of IL-1beta secretion by CGD PBMCs than did cell wall polysaccharides isolated from A. fumigatus.	Polysaccharides	19-34	interleukin 1 beta	Homo sapiens	81-89
27460640-6	2016	Docking predictions of FIP-Lrh on 14 glycans commonly found on cellular surfaces showed the best binding energy of -3.98 kcal/mol to N-acetylgalactosamine and N-acetylglucosamine.	Polysaccharides	37-44	upstream transcription factor 2, c-fos interacting	Homo sapiens	23-26
27459991-18	2016	CONCLUSIONS: Gal-8, either secreted or exogenously enriched in the media, and acting through extracellular glycan interactions, constitutes a strong stimulus of directional migration in glioblastoma U87 cells and for the first time emerges as a factor that promotes proliferation and prevents apoptosis in cancerous cells.	Polysaccharides	107-113	galectin 8	Homo sapiens	13-18
27458028-6	2016	All three glycan families contributed to E-selectin dependent cell adhesion with N-glycans contributing to all aspects of the leukocyte adhesion cascade, O-glycans only being important during initial recruitment, and GSLs stabilizing slow cell rolling and the transition to firm arrest.	Polysaccharides	10-16	selectin E	Homo sapiens	41-51
27439378-7	2016	Furthermore, we found that Alum-TLR7 increases anti-polysaccharide immune response even in the presence of a prior immune response against the carrier protein.	Polysaccharides	52-66	toll like receptor 7	Homo sapiens	32-36
27357658-0	2016	Structural basis for sulfation-dependent self-glycan recognition by the human immune-inhibitory receptor Siglec-8.	Polysaccharides	46-52	sialic acid binding Ig like lectin 8	Homo sapiens	105-113
27357658-1	2016	Siglec-8 is a human immune-inhibitory receptor that, when engaged by specific self-glycans, triggers eosinophil apoptosis and inhibits mast cell degranulation, providing an endogenous mechanism to down-regulate immune responses of these central inflammatory effector cells.	Polysaccharides	83-90	sialic acid binding Ig like lectin 8	Homo sapiens	0-8
27357658-4	2016	Our work provides critical structural and mechanistic insights into how Siglec-8 selectively recognizes its glycan target, rationalizes the functional impact of site-specific glycan sulfation in modulating this lectin-glycan interaction, and will enable the rational design of Siglec-8-targeted agonists to treat eosinophil- and mast cell-related allergic and inflammatory diseases, such as asthma.	Polysaccharides	108-114	sialic acid binding Ig like lectin 8	Homo sapiens	72-80
27357658-4	2016	Our work provides critical structural and mechanistic insights into how Siglec-8 selectively recognizes its glycan target, rationalizes the functional impact of site-specific glycan sulfation in modulating this lectin-glycan interaction, and will enable the rational design of Siglec-8-targeted agonists to treat eosinophil- and mast cell-related allergic and inflammatory diseases, such as asthma.	Polysaccharides	175-181	sialic acid binding Ig like lectin 8	Homo sapiens	72-80
27357658-4	2016	Our work provides critical structural and mechanistic insights into how Siglec-8 selectively recognizes its glycan target, rationalizes the functional impact of site-specific glycan sulfation in modulating this lectin-glycan interaction, and will enable the rational design of Siglec-8-targeted agonists to treat eosinophil- and mast cell-related allergic and inflammatory diseases, such as asthma.	Polysaccharides	175-181	sialic acid binding Ig like lectin 8	Homo sapiens	72-80
27438765-1	2016	The dense patch of high-mannose-type glycans surrounding the N332 glycan on the HIV envelope glycoprotein (Env) is targeted by multiple broadly neutralizing antibodies (bnAbs).	Polysaccharides	37-43	endogenous retrovirus group K member 20	Homo sapiens	107-110
27438765-0	2016	A Prominent Site of Antibody Vulnerability on HIV Envelope Incorporates a Motif Associated with CCR5 Binding and Its Camouflaging Glycans.	Polysaccharides	130-137	C-C motif chemokine receptor 5	Homo sapiens	96-100
27225479-10	2016	On the lymphatic cell surface, VEGF-C induced robust association between syndecan-4 and VEGF receptor-3, which was sensitive to glycan disruption.	Polysaccharides	128-134	vascular endothelial growth factor C	Mus musculus	31-37
27438765-1	2016	The dense patch of high-mannose-type glycans surrounding the N332 glycan on the HIV envelope glycoprotein (Env) is targeted by multiple broadly neutralizing antibodies (bnAbs).	Polysaccharides	37-44	endogenous retrovirus group K member 20	Homo sapiens	84-105
27438765-1	2016	The dense patch of high-mannose-type glycans surrounding the N332 glycan on the HIV envelope glycoprotein (Env) is targeted by multiple broadly neutralizing antibodies (bnAbs).	Polysaccharides	37-44	endogenous retrovirus group K member 20	Homo sapiens	107-110
27438765-1	2016	The dense patch of high-mannose-type glycans surrounding the N332 glycan on the HIV envelope glycoprotein (Env) is targeted by multiple broadly neutralizing antibodies (bnAbs).	Polysaccharides	37-43	endogenous retrovirus group K member 20	Homo sapiens	84-105
27401917-12	2016	Within 72 h of treatment with the polysaccharides, expression of IL-7 gene was up-regulated over 2 times.	Polysaccharides	34-49	interleukin 7	Rattus norvegicus	65-69
27401917-14	2016	The secreted IL-7 stimulated proliferation of freshly isolated T lymphocytes within 6 h. The effect of the polysaccharides were found to be molecular weight depended, with low molecular weight having a profound effect compared to high molecular weight and total crude extract.	Polysaccharides	107-122	interleukin 7	Rattus norvegicus	13-17
27401917-16	2016	Of great importance, is the ability of the polysaccharides to up-regulate anticancer cytokine IL-7, which is important in proliferation and maturation of immune cells and it is associated with better prognosis in cancer.	Polysaccharides	43-58	interleukin 7	Rattus norvegicus	94-98
27337058-6	2016	SEP was a novel polysaccharide from Sepia esculenta ink with a unique primary structure mainly composed of GalN and Ara that accounted for almost half of all monosaccharides: their ratio was nearly one-to-one.	Polysaccharides	16-30	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
27337058-7	2016	Besides, the polysaccharide contained a small number of Fuc and tiny amounts of Man, GlcN, GlcA, and GalA.	Polysaccharides	13-27	galactosidase alpha	Homo sapiens	101-105
27225479-10	2016	On the lymphatic cell surface, VEGF-C induced robust association between syndecan-4 and VEGF receptor-3, which was sensitive to glycan disruption.	Polysaccharides	128-134	syndecan 4	Mus musculus	73-83
27345319-6	2016	Gene expression profiling of equine preimplantation conceptuses revealed expression of neuraminidase 2 (NEU2), an enzyme that cleaves sialic acid from polysaccharide chains.	Polysaccharides	151-165	neuraminidase 2	Equus caballus	87-102
27389966-7	2016	During infection, Salmonella used its two GHs sialidase nanH and amylase malS for internalization by targeting different glycan structures.	Polysaccharides	121-127	neuraminidase 1	Homo sapiens	56-60
26881299-2	2016	To this end, we hypothesized that polysaccharides substituted with sulfate groups would amplify growth factor receptor activation and stimulate phenotypic activities of endothelial cells involved in neovascularization.	Polysaccharides	34-49	receptor-like tyrosine kinase	Mus musculus	96-118
27114558-2	2016	CSAS produces the activated sugar donor, CMP-sialic acid, which serves as a substrate for sialyltransferases to modify glycan termini with sialic acid.	Polysaccharides	119-125	CMP-sialic acid synthase	Drosophila melanogaster	0-4
27345319-6	2016	Gene expression profiling of equine preimplantation conceptuses revealed expression of neuraminidase 2 (NEU2), an enzyme that cleaves sialic acid from polysaccharide chains.	Polysaccharides	151-165	neuraminidase 2	Equus caballus	104-108
27044345-0	2016	Molecular structure, chemical properties and biological activities of Pinto bean pod polysaccharide.	Polysaccharides	85-99	forkhead box L2	Homo sapiens	70-75
26911287-1	2016	Defining how a glycan-binding protein (GBP) specifically selects its cognate glycan from among the ensemble of glycans within the cellular glycome is an area of intense study.	Polysaccharides	15-21	transmembrane protein 132A	Homo sapiens	39-42
26911287-1	2016	Defining how a glycan-binding protein (GBP) specifically selects its cognate glycan from among the ensemble of glycans within the cellular glycome is an area of intense study.	Polysaccharides	111-118	transmembrane protein 132A	Homo sapiens	15-37
26911287-1	2016	Defining how a glycan-binding protein (GBP) specifically selects its cognate glycan from among the ensemble of glycans within the cellular glycome is an area of intense study.	Polysaccharides	111-118	transmembrane protein 132A	Homo sapiens	39-42
26911287-7	2016	When applied to a collection of 10 GBP-glycan complexes, for which crystallographic and array data have been reported, grafting provided a structural rationalization for the binding specificity of &gt;90% of 1223 arrayed glycans.	Polysaccharides	39-45	transmembrane protein 132A	Homo sapiens	35-38
26911287-7	2016	When applied to a collection of 10 GBP-glycan complexes, for which crystallographic and array data have been reported, grafting provided a structural rationalization for the binding specificity of &gt;90% of 1223 arrayed glycans.	Polysaccharides	221-228	transmembrane protein 132A	Homo sapiens	35-38
27044345-1	2016	Pinto bean pod polysaccharide (PBPP) was successfully extracted with yield of 38.5g/100g and the PBPP gave total carbohydrate and uronic acid contents of 286.2mg maltose equivalent/g and 374.3mgGal/g, respectively.	Polysaccharides	15-29	forkhead box L2	Homo sapiens	0-5
29071911-0	2016	[Effect of Electroacupuncture plus Polysaccharide of Gastrodia elata Blume on Expression of Nestin and Brain Derived Neurotrophic Factor in the Basolateral Amygdala of Focal Cerebral Ischemia Rats].	Polysaccharides	35-49	nestin	Rattus norvegicus	92-98
27125588-8	2016	CONCLUSION: The polysaccharide-rich extract of C. ferra stem barks accelerates wound healing by the control of the inflammatory phase and attenuates hypernociception via modulation of inflammatory mediators (TNF-alpha, IL-1beta, NO, TGF-beta).	Polysaccharides	16-30	tumor necrosis factor	Rattus norvegicus	208-217
27125588-8	2016	CONCLUSION: The polysaccharide-rich extract of C. ferra stem barks accelerates wound healing by the control of the inflammatory phase and attenuates hypernociception via modulation of inflammatory mediators (TNF-alpha, IL-1beta, NO, TGF-beta).	Polysaccharides	16-30	interleukin 1 beta	Rattus norvegicus	219-227
27125588-8	2016	CONCLUSION: The polysaccharide-rich extract of C. ferra stem barks accelerates wound healing by the control of the inflammatory phase and attenuates hypernociception via modulation of inflammatory mediators (TNF-alpha, IL-1beta, NO, TGF-beta).	Polysaccharides	16-30	transforming growth factor, beta 1	Rattus norvegicus	233-241
27294781-4	2016	The glycan-binding interface on SV2 is targeted by a human BoNT/A1-neutralizing antibody currently licensed as an antibotulism drug.	Polysaccharides	4-10	synaptic vesicle glycoprotein 2A	Homo sapiens	32-35
26855319-5	2016	This review focuses on the biological relevance of lectin-glycan interactions in the tumor microenvironment (mainly illustrated by the immunosuppressive and pro-angiogenic activities of galectin-1) and the design of functionalized nanoparticles for pharmacological delivery of multimeric glycans, lectins or selective inhibitors of lectin-glycan interactions with antitumor activity.	Polysaccharides	58-64	galectin 1	Homo sapiens	186-196
26855319-5	2016	This review focuses on the biological relevance of lectin-glycan interactions in the tumor microenvironment (mainly illustrated by the immunosuppressive and pro-angiogenic activities of galectin-1) and the design of functionalized nanoparticles for pharmacological delivery of multimeric glycans, lectins or selective inhibitors of lectin-glycan interactions with antitumor activity.	Polysaccharides	288-295	galectin 1	Homo sapiens	186-196
26855319-5	2016	This review focuses on the biological relevance of lectin-glycan interactions in the tumor microenvironment (mainly illustrated by the immunosuppressive and pro-angiogenic activities of galectin-1) and the design of functionalized nanoparticles for pharmacological delivery of multimeric glycans, lectins or selective inhibitors of lectin-glycan interactions with antitumor activity.	Polysaccharides	288-294	galectin 1	Homo sapiens	186-196
27358497-4	2016	To develop a targeted drug delivery platform, we used a fucosylated polysaccharide with nanomolar affinity to P-selectin.	Polysaccharides	68-82	selectin P	Homo sapiens	110-120
27129198-4	2016	The function of these individual glycans in Notch signaling has been investigated, primarily by disrupting their individual glycosyltransferases.	Polysaccharides	33-40	Notch	Drosophila melanogaster	44-49
26551914-8	2016	Moreover, by fluorescence microscopy we demonstrated that Gal1 promoted glycan-dependent heterotypic adhesion of HepG2 cells to SK-HEP-1 SECs.	Polysaccharides	72-78	galectin 1	Homo sapiens	58-62
27208279-4	2016	Analyses of these genes suggest that ANT and AIL6 regulate floral organ initiation and growth through modifications to the cell wall polysaccharide pectin.	Polysaccharides	133-147	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	37-40
27208279-4	2016	Analyses of these genes suggest that ANT and AIL6 regulate floral organ initiation and growth through modifications to the cell wall polysaccharide pectin.	Polysaccharides	133-147	AINTEGUMENTA-like 6	Arabidopsis thaliana	45-49
27524986-11	2016	Given that FEI2 is required for SOS5 function, we propose that FEI2 serves to localize SOS5 at the plasma membrane where it establishes interactions with mucilage polysaccharides, notably pectins, required for mucilage adherence prior to SOS5 being released into the apoplast.	Polysaccharides	163-178	Leucine-rich repeat protein kinase family protein	Arabidopsis thaliana	11-15
27524986-11	2016	Given that FEI2 is required for SOS5 function, we propose that FEI2 serves to localize SOS5 at the plasma membrane where it establishes interactions with mucilage polysaccharides, notably pectins, required for mucilage adherence prior to SOS5 being released into the apoplast.	Polysaccharides	163-178	Leucine-rich repeat protein kinase family protein	Arabidopsis thaliana	63-67
27524986-11	2016	Given that FEI2 is required for SOS5 function, we propose that FEI2 serves to localize SOS5 at the plasma membrane where it establishes interactions with mucilage polysaccharides, notably pectins, required for mucilage adherence prior to SOS5 being released into the apoplast.	Polysaccharides	163-178	Fasciclin-like arabinogalactan family protein	Arabidopsis thaliana	87-91
27524986-11	2016	Given that FEI2 is required for SOS5 function, we propose that FEI2 serves to localize SOS5 at the plasma membrane where it establishes interactions with mucilage polysaccharides, notably pectins, required for mucilage adherence prior to SOS5 being released into the apoplast.	Polysaccharides	163-178	Fasciclin-like arabinogalactan family protein	Arabidopsis thaliana	87-91
27083824-0	2016	Study on quality control of sulfated polysaccharide drug, propylene glycol alginate sodium sulfate (PSS).	Polysaccharides	37-51	PSS	Homo sapiens	100-103
27083824-1	2016	The combination of biological and chemical analysis methods was developed to improve quality control of propylene glycol alginate sodium sulfate (PSS), a sulfated polysaccharide drug.	Polysaccharides	163-177	PSS	Homo sapiens	146-149
27083836-4	2016	The crude polysaccharides (BSSP) from the bamboo shoots shell showed hypoglycemic activity on the high fat diet and streptozotocin induced diabetic mice in a dose-dependent manner.	Polysaccharides	10-25	kallikrein related-peptidase 6	Mus musculus	27-31
29071911-0	2016	[Effect of Electroacupuncture plus Polysaccharide of Gastrodia elata Blume on Expression of Nestin and Brain Derived Neurotrophic Factor in the Basolateral Amygdala of Focal Cerebral Ischemia Rats].	Polysaccharides	35-49	brain-derived neurotrophic factor	Rattus norvegicus	103-136
27083352-0	2016	A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-kappaB in THP-1 monocytes.	Polysaccharides	2-16	GLI family zinc finger 2	Homo sapiens	133-138
27324620-1	2016	Polysialic acid (PSA) is a large negatively charged glycan mainly attached to the neural cell adhesion molecule (NCAM).	Polysaccharides	52-58	neural cell adhesion molecule 1	Homo sapiens	82-111
27324620-1	2016	Polysialic acid (PSA) is a large negatively charged glycan mainly attached to the neural cell adhesion molecule (NCAM).	Polysaccharides	52-58	neural cell adhesion molecule 1	Homo sapiens	113-117
27354815-2	2016	The aim of this study was to investigate the impact of polysaccharide isolated from Panax notoginseng (PPN) on the proliferation of H22 liver cancer cells and the survival of the tumor-bearing mice transplanted with H22 cells.	Polysaccharides	55-69	porcupine O-acyltransferase	Mus musculus	103-106
27354815-3	2016	MATERIALS AND METHODS: Polysaccharide from PPN was added to the culture medium of mouse hepatoma H22 cells at different doses.	Polysaccharides	23-37	porcupine O-acyltransferase	Mus musculus	43-46
27354815-8	2016	RESULTS: Polysaccharide from PPN inhibited the growth of H22 cells and significantly prolonged the survival of tumor-bearing mice.	Polysaccharides	9-23	porcupine O-acyltransferase	Mus musculus	29-32
27129262-11	2016	The cell surface glycans display an increase of sialylation alpha2-6, poly-LacNAc, and fucosylation, all known epitopes found in different tumor models.	Polysaccharides	17-24	immunoglobulin binding protein 1	Homo sapiens	60-68
27131125-4	2016	Here we use two glycan labeling reactions to monitor neuraminidase activity toward glycan substrates.	Polysaccharides	16-22	neuraminidase 1	Homo sapiens	53-66
27131125-4	2016	Here we use two glycan labeling reactions to monitor neuraminidase activity toward glycan substrates.	Polysaccharides	83-89	neuraminidase 1	Homo sapiens	53-66
27131125-5	2016	While both periodate oxidation and aniline-catalyzed oxime ligation (PAL) and galactose oxidase and aniline-catalyzed oxime ligation (GAL) can be used to monitor neuraminidase activity toward glycans in microtiter plates, only GAL accurately measured neuraminidase activity toward glycans displayed on a commercial glass slide microarray.	Polysaccharides	192-199	neuraminidase 1	Homo sapiens	162-175
27131125-5	2016	While both periodate oxidation and aniline-catalyzed oxime ligation (PAL) and galactose oxidase and aniline-catalyzed oxime ligation (GAL) can be used to monitor neuraminidase activity toward glycans in microtiter plates, only GAL accurately measured neuraminidase activity toward glycans displayed on a commercial glass slide microarray.	Polysaccharides	281-288	neuraminidase 1	Homo sapiens	162-175
27053108-6	2016	In vivo, elevated expression of HTM1 causes glycan trimming on misfolded and folded proteins, but only degradation of the non-native species is accelerated.	Polysaccharides	44-50	alpha-1,2-mannosidase MNL1	Saccharomyces cerevisiae S288C	32-36
27275831-3	2016	In the case of HIV, antiviral activity of CV-N is postulated to require multivalent interactions with envelope protein gp120, achieved through a pseudo-repeat of sequence that adopts two near-identical glycan-binding sites, and possibly involves a 3D-domain-swapped dimeric form of CV-N.	Polysaccharides	202-208	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	119-124
27177499-16	2016	In conclusion, hCG is the major pregnancy glycoprotein hormone, whose maternal concentration and glycan structure change all along pregnancy.	Polysaccharides	97-103	hypertrichosis 2 (generalised, congenital)	Homo sapiens	15-18
27133300-1	2016	AIM: Chinese medicine CGA formula consists of polysaccharide from Cordyceps sinensis mycelia (CS-PS), gypenosides and amygdalin, which is derived from Fuzheng Huayu (FZHY) capsule for treating liver fibrosis.	Polysaccharides	46-60	chromogranin A	Rattus norvegicus	22-25
26747425-4	2016	Recombinant human galectins (hGal)-1, -3, -4, -7, -8 and -9 bound selectively to glycans, with each galectin recognizing a relatively unique binding motif; by contrast hGal-2 did not recognize HMGs, but did bind to the human blood group A Type 2 determinants on other microarrays.	Polysaccharides	81-88	galanin and GMAP prepropeptide	Homo sapiens	29-33
26776149-2	2016	Despite similar operating conditions and identical DOM properties in the feed waters, NMBR exhibited a lower propensity to release polysaccharide-like compounds with low molecular weight by bacterial activities compared to CMBR.	Polysaccharides	131-145	neuromedin B receptor	Homo sapiens	86-90
27428423-6	2016	Androgen exposure stimulated synthesis of glycan structures downstream of this core set of regulated enzymes including sialyl-Tn (sTn), sialyl Lewis(X) (SLe(X)), O-GlcNAc and chondroitin sulphate, suggesting androgen regulation of the core set of enzymes controls key steps in glycan synthesis.	Polysaccharides	42-48	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	162-170
26873821-3	2016	MS of native transferrin detects a lack of glycans characteristic to the classical CDG-I type of molecular abnormality.	Polysaccharides	43-50	transferrin	Homo sapiens	13-24
27006333-0	2016	Glycan-deficient PrP stimulates VEGFR2 signaling via glycosaminoglycan.	Polysaccharides	0-6	major prion protein	Cricetulus griseus	17-20
27006333-0	2016	Glycan-deficient PrP stimulates VEGFR2 signaling via glycosaminoglycan.	Polysaccharides	0-6	vascular endothelial growth factor receptor 2	Cricetulus griseus	32-38
27006333-3	2016	Compared to fully-glycosylated PrP, glycan-deficient PrP preferentially partitions to lipid raft.	Polysaccharides	36-42	major prion protein	Cricetulus griseus	53-56
27006333-4	2016	In CHO cells glycan-deficient PrP also interacts with glycosaminoglycan (GAG) and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in VEGFR2 activation and enhanced Akt phosphorylation.	Polysaccharides	13-19	major prion protein	Cricetulus griseus	30-33
27006333-4	2016	In CHO cells glycan-deficient PrP also interacts with glycosaminoglycan (GAG) and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in VEGFR2 activation and enhanced Akt phosphorylation.	Polysaccharides	13-19	vascular endothelial growth factor receptor 2	Cricetulus griseus	82-127
27006333-4	2016	In CHO cells glycan-deficient PrP also interacts with glycosaminoglycan (GAG) and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in VEGFR2 activation and enhanced Akt phosphorylation.	Polysaccharides	13-19	vascular endothelial growth factor receptor 2	Cricetulus griseus	129-135
27006333-4	2016	In CHO cells glycan-deficient PrP also interacts with glycosaminoglycan (GAG) and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in VEGFR2 activation and enhanced Akt phosphorylation.	Polysaccharides	13-19	vascular endothelial growth factor receptor 2	Cricetulus griseus	151-157
27006333-5	2016	Accordingly, CHO cells expressing glycan-deficient PrP lacking the GAG binding motif or cells treated with heparinase to remove GAG show diminished Akt signaling.	Polysaccharides	34-40	major prion protein	Cricetulus griseus	51-54
27006333-6	2016	Being in lipid raft is critical, chimeric glycan-deficient PrP with CD4 transmembrane and cytoplasmic domains is absent in lipid raft and does not activate Akt signaling.	Polysaccharides	42-48	major prion protein	Cricetulus griseus	59-62
27006333-7	2016	CHO cells bearing glycan-deficient PrP also exhibit enhanced cellular adhesion and migration.	Polysaccharides	18-24	major prion protein	Cricetulus griseus	35-38
27006333-8	2016	Based on these findings, we propose a model in which glycan-deficient PrP, GAG, and VEGFR2 interact, activating VEGFR2 and resulting in changes in cellular behavior.	Polysaccharides	53-59	major prion protein	Cricetulus griseus	70-73
27006333-8	2016	Based on these findings, we propose a model in which glycan-deficient PrP, GAG, and VEGFR2 interact, activating VEGFR2 and resulting in changes in cellular behavior.	Polysaccharides	53-59	vascular endothelial growth factor receptor 2	Cricetulus griseus	84-90
27006333-8	2016	Based on these findings, we propose a model in which glycan-deficient PrP, GAG, and VEGFR2 interact, activating VEGFR2 and resulting in changes in cellular behavior.	Polysaccharides	53-59	vascular endothelial growth factor receptor 2	Cricetulus griseus	112-118
27028511-6	2016	As shown for several other AMPs, ApoE (133-150) is structured in the presence of TFE and of membrane-mimicking agents, like SDS, or bacterial surface lipopolysaccharide (LPS), and an anionic polysaccharide, alginate, which mimics anionic capsular exo-polysaccharides of several pathogenic microorganisms.	Polysaccharides	154-168	apolipoprotein E	Homo sapiens	33-37
26858341-4	2016	In this study, a G &gt; A (nucleotide 307) missense mutation in the porcine alpha1,2fucosyltransferase 1 gene (FUT1), which has been reported to prevent infections by the common porcine enteric pathogen F18 fimbriated Escherichia coli, provided a unique opportunity to study glycan structures potentially involved in intestinal infections.	Polysaccharides	275-281	galactoside alpha-(1,2)-fucosyltransferase 1	Sus scrofa	111-115
26933169-4	2016	To assess the role of HCELL in directing HSC migration to marrow, a method called "glycosyltransferase-programmed stereosubstitution" (GPS) was developed to custom-modify CD44 glycans to enforce HCELL expression on viable cell surfaces.	Polysaccharides	176-183	CD44 molecule (Indian blood group)	Homo sapiens	171-175
26747425-5	2016	Unlike other galectins, hGal-7 preferentially bound to glycans expressing a terminal Type 1 (Galbeta1-3GlcNAc) sequence, a motif that had eluded detection on non-HMG glycan microarrays.	Polysaccharides	55-62	galanin and GMAP prepropeptide	Homo sapiens	24-28
26747425-5	2016	Unlike other galectins, hGal-7 preferentially bound to glycans expressing a terminal Type 1 (Galbeta1-3GlcNAc) sequence, a motif that had eluded detection on non-HMG glycan microarrays.	Polysaccharides	55-61	galanin and GMAP prepropeptide	Homo sapiens	24-28
27183571-3	2016	Structural analyses of Fab fragments of mAbs 023.102 and pn132p2C05 in complex with portions of the 23F polysaccharide revealed five germline-encoded residues in contact with the key component, l-rhamnose.	Polysaccharides	104-118	FA complementation group B	Homo sapiens	23-26
27035516-0	2016	Optimal sequence of antisense DNA to silence YB-1 in lung cancer by use of a novel polysaccharide drug delivery system.	Polysaccharides	83-97	Y-box binding protein 1	Homo sapiens	45-49
26858137-5	2016	The rapid clearance correlates with lower capsular polysaccharide production by the DeltaptsH mutant, which is probably also responsible for its increased adhesion to Hec-1-B epithelial cells.	Polysaccharides	51-65	NDC80 kinetochore complex component	Homo sapiens	167-172
27064211-2	2016	In mice, we have already demonstrated that the OS chain in the epitope for Ts4 is a fucosylated agalacto-complex-type biantennary glycan carrying bisecting N-acetylglucosamine.	Polysaccharides	130-136	Trichinella spiralis resistance 4	Mus musculus	75-78
27064211-10	2016	The Ts4-recognized fucosylated agalactobiantennary complex-type glycan with bisecting N-acetylglucosamine and Naglu on cauda epididymal spermatozoa may play a role in the process of fertilization.	Polysaccharides	64-70	Trichinella spiralis resistance 4	Mus musculus	4-7
27064211-10	2016	The Ts4-recognized fucosylated agalactobiantennary complex-type glycan with bisecting N-acetylglucosamine and Naglu on cauda epididymal spermatozoa may play a role in the process of fertilization.	Polysaccharides	64-70	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	110-115
26993530-0	2016	Effects of the ultra-high pressure on structure and alpha-glucosidase inhibition of polysaccharide from Astragalus.	Polysaccharides	84-98	sucrase-isomaltase	Homo sapiens	52-69
27040214-6	2016	Fibronectin adsorption, keratocyte adhesion, and cell spreading exhibited a positive correlation with DD due to the chemical functionality of polysaccharides (bearing acetyl and amino groups) and increase of substrate stiffness and crystallinity.	Polysaccharides	142-157	fibronectin 1	Homo sapiens	0-11
27240337-3	2016	Locust bean gum (LBG) is a polysaccharide composed of galactose and mannose residues, which may favour specific recognition by macrophages and potentiate phagocytosis.	Polysaccharides	27-41	brain expressed associated with NEDD4 1	Homo sapiens	7-11
27328060-8	2016	LpMab-13 recognized glycan-deficient hPDPN in flow cytometry, indicating that the interaction between LpMab-13 and hPDPN is independent of its glycosylation.	Polysaccharides	20-26	podoplanin	Homo sapiens	37-42
27310476-7	2016	Among the total 24 glycan peaks (GP1-GP24), ROC analysis showed only GP1 prediction to be highly sensitive with an area under the curve (AUC) = 0.881.	Polysaccharides	19-25	GTP binding protein 1	Homo sapiens	33-36
27105909-4	2016	We report herein that the polysaccharide heparin interacts with both apoA1 and SAA in HDL isolated from plasma of inflamed mice.	Polysaccharides	26-40	apolipoprotein A-I	Mus musculus	69-74
27105909-4	2016	We report herein that the polysaccharide heparin interacts with both apoA1 and SAA in HDL isolated from plasma of inflamed mice.	Polysaccharides	26-40	serum amyloid A cluster	Mus musculus	79-82
27216943-2	2016	The aim of this study is to investigate the antitumor activity of the novel polysaccharide named SPS from Sargassum integerrimum, elucidate the underlying anticancer mechanism in a human lung cancer cell line A549, and evaluate its anti-angiogenic activity both in vitro and in vivo.	Polysaccharides	76-90	selenophosphate synthetase 1	Homo sapiens	97-100
26974373-1	2016	Propylene glycol alginate sodium sulfate (PSS), a sulfated polysaccharide derivative, has been used as a heparinoid drug to prevent and treat hyperlipidemia and ischemic cardio-cerebrovascular diseases in China for nearly 30 years.	Polysaccharides	59-73	PSS	Homo sapiens	42-45
27031581-7	2016	Glycan-bound virus is detected by quantifying the viral neuraminidase activity via a fluorogenic reporter, 2"-(4-methylumbelliferyl)-alpha-d-N-acetylneuraminic acid.	Polysaccharides	0-6	neuraminidase 1	Homo sapiens	56-69
27161092-6	2016	Our results demonstrated that the FUT2 determines the O-glycosylation pattern of Muc5ac, with Fut2 knock-out leading to a marked decrease in alpha1,2-fucosylated structures and increased expression of the terminal type 1 glycan structure Lewis-a.	Polysaccharides	221-227	fucosyltransferase 2	Mus musculus	34-38
27350914-0	2016	Oyster crude polysaccharides attenuates lipopolysaccharide-induced cytokines production and PPARgamma expression in weanling piglets.	Polysaccharides	13-28	peroxisome proliferator activated receptor gamma	Homo sapiens	92-101
27313494-6	2016	Lectin microarray analysis revealed significant differences among the four fractions in terms of glycan binding to the lectins LCA, AAL, MPL, WGA and PWM in YTS1 cell, STL, Jacalin, VVA, LCA and WGA in KK47, and ConA, GNA, VVA and ACA in HCV29 cell.	Polysaccharides	97-103	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	137-140
27209430-0	2016	Alteration of matrix metalloproteinase-3 O-glycan structure as a biomarker for disease activity of rheumatoid arthritis.	Polysaccharides	43-49	matrix metallopeptidase 3	Homo sapiens	14-40
26976925-0	2016	Human DC-SIGN binds specific human milk glycans.	Polysaccharides	40-47	CD209 molecule	Homo sapiens	6-13
26976925-4	2016	Unexpectedly, DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) showed robust binding to many HMGs, whereas other C-type lectins failed to bind, and Siglec-5 and Siglec-9 showed weak binding to a few glycans.	Polysaccharides	228-235	CD209 molecule	Homo sapiens	14-81
26976925-4	2016	Unexpectedly, DC-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) showed robust binding to many HMGs, whereas other C-type lectins failed to bind, and Siglec-5 and Siglec-9 showed weak binding to a few glycans.	Polysaccharides	228-235	CD209 molecule	Homo sapiens	83-90
26976925-5	2016	By contrast, most hGBP bound to multiple glycans on other microarrays lacking HMGs.	Polysaccharides	41-48	transmembrane protein 132A	Homo sapiens	18-22
26976925-7	2016	Binding of DC-SIGN to the simple HMGs 2"-fucosyl-lactose (2"-FL) and 3-fucosyl-lactose (3-FL) was confirmed by flow cytometry to beads conjugated with 2"-FL or 3-FL, as well as the ability of the free glycans to inhibit DC-SIGN binding.	Polysaccharides	201-208	CD209 molecule	Homo sapiens	11-18
27009211-2	2016	The V. cholerae O1-specific polysaccharide (OSP) component of lipopolysaccharide (LPS) is responsible for serogroup specificity, and it is unclear if young children are capable of developing memory B cell responses against OSP, a T cell-independent antigen, following cholera.	Polysaccharides	28-42	claudin 11	Homo sapiens	44-47
27161092-6	2016	Our results demonstrated that the FUT2 determines the O-glycosylation pattern of Muc5ac, with Fut2 knock-out leading to a marked decrease in alpha1,2-fucosylated structures and increased expression of the terminal type 1 glycan structure Lewis-a.	Polysaccharides	221-227	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	81-87
27136597-4	2016	As the HNK-1 glycan also enhances neuronal functions, we tested whether similar sulfated oligo- and polysaccharides from seaweed could be suitable, in addition to polySia, for finding potential new routes into patient care focusing on an improved cure for various neuronal diseases.	Polysaccharides	13-19	beta-1,3-glucuronyltransferase 1	Homo sapiens	7-12
27161092-6	2016	Our results demonstrated that the FUT2 determines the O-glycosylation pattern of Muc5ac, with Fut2 knock-out leading to a marked decrease in alpha1,2-fucosylated structures and increased expression of the terminal type 1 glycan structure Lewis-a.	Polysaccharides	221-227	fucosyltransferase 2	Mus musculus	94-98
27033327-5	2016	The workflow features enzymatic release of GSL glycans with a novel broad-specificity endoglycoceramidase I (EGCase I) from Rhodococcus triatomea, selective glycan capture on hydrazide beads on a robotics platform, 2AB-fluorescent glycan labeling, and analysis by UPLC-HILIC-FLD.	Polysaccharides	47-53	cathepsin A	Homo sapiens	43-46
27114034-0	2016	Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G. The HIV-1-envelope (Env) trimer is covered by a glycan shield of ~90 N-linked oligosaccharides, which comprises roughly half its mass and is a key component of HIV evasion from humoral immunity.	Polysaccharides	37-43	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	15-18
27114034-0	2016	Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G. The HIV-1-envelope (Env) trimer is covered by a glycan shield of ~90 N-linked oligosaccharides, which comprises roughly half its mass and is a key component of HIV evasion from humoral immunity.	Polysaccharides	37-43	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	81-95
27114034-0	2016	Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G. The HIV-1-envelope (Env) trimer is covered by a glycan shield of ~90 N-linked oligosaccharides, which comprises roughly half its mass and is a key component of HIV evasion from humoral immunity.	Polysaccharides	37-43	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	97-100
27114034-0	2016	Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G. The HIV-1-envelope (Env) trimer is covered by a glycan shield of ~90 N-linked oligosaccharides, which comprises roughly half its mass and is a key component of HIV evasion from humoral immunity.	Polysaccharides	125-131	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	15-18
27114034-0	2016	Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G. The HIV-1-envelope (Env) trimer is covered by a glycan shield of ~90 N-linked oligosaccharides, which comprises roughly half its mass and is a key component of HIV evasion from humoral immunity.	Polysaccharides	125-131	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	81-95
27114034-0	2016	Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G. The HIV-1-envelope (Env) trimer is covered by a glycan shield of ~90 N-linked oligosaccharides, which comprises roughly half its mass and is a key component of HIV evasion from humoral immunity.	Polysaccharides	125-131	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	97-100
27114034-2	2016	These structures reveal the HIV-1-glycan shield to comprise a network of interlocking oligosaccharides, substantially ordered by glycan crowding, that encase the protein component of Env and enable HIV-1 to avoid most antibody-mediated neutralization.	Polysaccharides	34-40	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	183-186
27033327-5	2016	The workflow features enzymatic release of GSL glycans with a novel broad-specificity endoglycoceramidase I (EGCase I) from Rhodococcus triatomea, selective glycan capture on hydrazide beads on a robotics platform, 2AB-fluorescent glycan labeling, and analysis by UPLC-HILIC-FLD.	Polysaccharides	157-163	cathepsin A	Homo sapiens	43-46
26602221-0	2016	ABH-Glycan Microarray Characterizes ABO Subtype Antibodies: Fine Specificity of Immune Tolerance After ABO-Incompatible Transplantation.	Polysaccharides	4-10	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	0-3
26602221-0	2016	ABH-Glycan Microarray Characterizes ABO Subtype Antibodies: Fine Specificity of Immune Tolerance After ABO-Incompatible Transplantation.	Polysaccharides	4-10	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	36-39
26602221-0	2016	ABH-Glycan Microarray Characterizes ABO Subtype Antibodies: Fine Specificity of Immune Tolerance After ABO-Incompatible Transplantation.	Polysaccharides	4-10	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	103-106
26840176-0	2016	Development of glycan specific lectin based immunoassay for detection of prostate specific antigen.	Polysaccharides	15-21	kallikrein related peptidase 3	Homo sapiens	73-98
26991001-7	2016	Zn(2+) binding to neuropilin-2 destabilizes the protein structure but this effect was counteracted by heparin, suggesting that modifications by glycans and zinc in the extracellular matrix may affect functional neuropilin-2 ligand binding and signalling activity.	Polysaccharides	144-151	neuropilin 2	Homo sapiens	18-30
26991001-7	2016	Zn(2+) binding to neuropilin-2 destabilizes the protein structure but this effect was counteracted by heparin, suggesting that modifications by glycans and zinc in the extracellular matrix may affect functional neuropilin-2 ligand binding and signalling activity.	Polysaccharides	144-151	neuropilin 2	Homo sapiens	211-223
26742622-9	2016	In addition, scanning and transmission electron microscopy and specific staining of polysaccharide SDS-PAGE gels confirmed that Komagataeibacter spp.	Polysaccharides	84-98	histocompatibility minor 13	Homo sapiens	145-148
26945068-5	2016	OS-9, an ER-resident lectin, acts downstream of Grp94 to further recognize misfolded alpha1 subunits in a glycan-dependent manner.	Polysaccharides	106-112	heat shock protein 90 beta family member 1	Homo sapiens	48-53
26507776-2	2016	In the present study, we demonstrated that hUGT1 expression altered the monosaccharide composition of cell wall matrix polysaccharides, such as pectic and hemicellulosic polysaccharides, which are biosynthesized in the Golgi lumen.	Polysaccharides	119-134	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	43-48
26507776-2	2016	In the present study, we demonstrated that hUGT1 expression altered the monosaccharide composition of cell wall matrix polysaccharides, such as pectic and hemicellulosic polysaccharides, which are biosynthesized in the Golgi lumen.	Polysaccharides	170-185	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	43-48
26507776-3	2016	An analysis of the monosaccharide composition of the cell wall matrix polysaccharides revealed that the ratio of galactose to total monosaccharides was significantly elevated in the hemicellulose II and pectin fractions of hUGT1-transgenic plants compared with that of control plants.	Polysaccharides	70-85	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	223-228
26507776-5	2016	These results indicated that, because of the enhanced UDP-galactose transport from the cytosol to the Golgi apparatus by hUGT1, galactose incorporation in the cell wall matrix polysaccharides increased.	Polysaccharides	176-191	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	121-126
26471808-5	2016	A direct method for hyaluronan histochemistry using a hyaluronan-binding protein probe (HABP) was used to visualize the polysaccharide.	Polysaccharides	120-134	hyaluronan binding protein 2	Homo sapiens	88-92
26724540-0	2016	Targeting CD44 receptor-positive lung tumors using polysaccharide-based nanocarriers: Influence of nanoparticle size and administration route.	Polysaccharides	51-65	CD44 molecule (Indian blood group)	Homo sapiens	10-14
27237321-4	2016	Herein, we show that targeting of DC glycan sulfation through mutation in the heparan sulfate biosynthetic enzyme N-deacetylase/N-sulfotransferase-1 (Ndst1) in mice increased DC maturation and inhibited trafficking of DCs to draining lymph nodes.	Polysaccharides	37-43	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	114-148
27237321-4	2016	Herein, we show that targeting of DC glycan sulfation through mutation in the heparan sulfate biosynthetic enzyme N-deacetylase/N-sulfotransferase-1 (Ndst1) in mice increased DC maturation and inhibited trafficking of DCs to draining lymph nodes.	Polysaccharides	37-43	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	Mus musculus	150-155
27040514-4	2016	Immobilised A21C11I8 displayed affinity for the glycosylated protein, glucose oxidase (GOx), which bound primarily through its glycan moiety.	Polysaccharides	127-133	hydroxyacid oxidase 1	Homo sapiens	70-85
27040514-4	2016	Immobilised A21C11I8 displayed affinity for the glycosylated protein, glucose oxidase (GOx), which bound primarily through its glycan moiety.	Polysaccharides	127-133	hydroxyacid oxidase 1	Homo sapiens	87-90
26945068-5	2016	OS-9, an ER-resident lectin, acts downstream of Grp94 to further recognize misfolded alpha1 subunits in a glycan-dependent manner.	Polysaccharides	106-112	adrenoceptor alpha 1D	Homo sapiens	85-91
26671885-9	2016	CONCLUSIONS: MprA regulates UPEC polysaccharide encapsulation, is essential for UPEC virulence, and can be targeted without inducing antibiotic resistance.	Polysaccharides	33-47	progestin and adipoQ receptor family member VII	Mus musculus	13-17
27121121-0	2016	Self-assembled Biodegradable Nanoparticles and Polysaccharides as Biomimetic ECM Nanostructures for the Synergistic effect of RGD and BMP-2 on Bone Formation.	Polysaccharides	47-62	bone morphogenetic protein 2	Homo sapiens	134-139
27067056-0	2016	Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.	Polysaccharides	10-17	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	4-9
27067056-5	2016	X-ray and EM structures revealed a VRC01-like angle of approach, but less favorable interactions between the DRVIA7 light-chain CDR1 and the N terminus with N276 and V5 glycans of gp120.	Polysaccharides	169-176	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	180-185
26993603-1	2016	Golgi Protein 73 (GP73) is a potential liver disease glycobiomarker warranting comprehensive analyses of its glycan structure and glycosylation function.	Polysaccharides	109-115	golgi membrane protein 1	Homo sapiens	0-16
26993603-1	2016	Golgi Protein 73 (GP73) is a potential liver disease glycobiomarker warranting comprehensive analyses of its glycan structure and glycosylation function.	Polysaccharides	109-115	golgi membrane protein 1	Homo sapiens	18-22
27148485-4	2016	Differentially, humans express twenty different STs in a tissue-specific manner, each of which catalyzes the attachment of sialic acids via different glycosidic linkages (alpha2-3, alpha2-6, or alpha2-8) to the underlying glycan chain.	Polysaccharides	222-228	immunoglobulin binding protein 1	Homo sapiens	194-202
27077376-0	2016	The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells.	Polysaccharides	66-72	integrin subunit beta 4	Homo sapiens	36-41
27548972-4	2016	When the nZVI dosage reached 100 mg   L-1, both extracellular protein and polysaccharides concentrations decreased obviously.	Polysaccharides	74-89	immunoglobulin kappa variable 1-16	Homo sapiens	38-41
26795039-8	2016	Regarding biological activity, Gal-8mut was unable to induce T-cell proliferation, but efficiently co-stimulated antigen-specific responses, bothin vitroandin vivo.Therefore Gal-8mut represents a useful tool to dissect the specificities of lectin-glycan interactions underlying distinctive Gal-8 activities on T-cell biology.	Polysaccharides	247-253	galectin 8	Homo sapiens	31-36
27144125-3	2016	The widespread use of pneumococcal-conjugate vaccines which target the capsular polysaccharide has led to decreased nasopharyngeal carriage of vaccine serotypes, but a concomitant increase in carriage of non-vaccine serotypes and nonencapsulated S. pneumoniae (NESp).	Polysaccharides	80-94	nestin	Homo sapiens	261-265
27073020-6	2016	A correlation study between the changes in glyco-gene expression and the HepG2 glycosylation profile suggests that the MGAT3 gene might be responsible for the glycan changes consistently induced by both doses of 5-aza-2dC.	Polysaccharides	159-165	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	119-124
26971709-5	2016	The powerful synergy of chemical synthesis and ENGase-mediated biocatalysis enabled the first synthesis of a glycoprotein bearing M6P-terminated N-glycans in which the glycans are attached to the peptide backbone by entirely natural linkages.	Polysaccharides	147-154	endo-beta-N-acetylglucosaminidase	Homo sapiens	47-53
26858256-3	2016	Our findings indicate that POSs are catabolized via a non-lysosomal glycan degradation pathway that involves a cytosolic endo-beta-N-acetylglucosaminidase (ENGase).	Polysaccharides	68-74	endo-beta-N-acetylglucosaminidase	Homo sapiens	111-154
26858256-3	2016	Our findings indicate that POSs are catabolized via a non-lysosomal glycan degradation pathway that involves a cytosolic endo-beta-N-acetylglucosaminidase (ENGase).	Polysaccharides	68-74	endo-beta-N-acetylglucosaminidase	Homo sapiens	156-162
26035113-8	2016	CONCLUSIONS: The results indicated that the serum fuc-fetuin A might serve as a potential glycan biomarker for distinguishing LC and HCC from LF, HBV-carriers and healthy controls.	Polysaccharides	90-96	alpha 2-HS glycoprotein	Homo sapiens	54-62
26813970-10	2016	Four glycan variables exhibited significant incremental value when combined with pro-SFTPB compared with pro-SFTPB alone with AUCs of 0.73, 0.72, 0.72, and 0.72 in the test set, indicating that serum glycan signatures have relevance to risk assessment for NSCLC.	Polysaccharides	200-206	surfactant protein B	Homo sapiens	85-90
25840959-9	2016	CONCLUSIONS: Lectin microarrays can be used to very accurately quantify the reaction of glycans with tumor tissues, and such profiles may represent the specific phenotypes, including N+ status, histological type, or p53 mutation of AGC.	Polysaccharides	88-95	tumor protein p53	Homo sapiens	216-219
26804001-0	2016	Anti-glycan antibodies halt axon regeneration in a model of Guillain Barre Syndrome axonal neuropathy by inducing microtubule disorganization via RhoA-ROCK-dependent inactivation of CRMP-2.	Polysaccharides	5-11	ras homolog family member A	Homo sapiens	146-150
26804001-0	2016	Anti-glycan antibodies halt axon regeneration in a model of Guillain Barre Syndrome axonal neuropathy by inducing microtubule disorganization via RhoA-ROCK-dependent inactivation of CRMP-2.	Polysaccharides	5-11	dihydropyrimidinase like 2	Homo sapiens	182-188
26589574-7	2016	The presence of sialyl core-1 glycan was repeatedly confirmed by probing with alpha-2,3-sialyltransferases, N-acetylgalactosaminide alpha-2,6-sialyltransferases and a beta-1,6-N-acetylglucosaminyltransferase that is specific for core-1 glycan.	Polysaccharides	30-36	glucosaminyl (N-acetyl) transferase 1	Bos taurus	167-207
26997434-1	2016	The glycosyltransferases chondroitin sulfate synthase 1 (CHSY1) and exostoses-like 3 (EXTL3) specifically function in biosynthesis of the glycans chondroitin sulfate and heparan sulfate, respectively.	Polysaccharides	138-145	chondroitin sulfate synthase 1	Homo sapiens	25-55
26979432-11	2016	These results demonstrate that sialylation of VN glycans regulates stress fiber formation and cell spreading of dermal fibroblast cells via a heparin binding site.	Polysaccharides	49-56	vitronectin	Mus musculus	46-48
26983412-8	2016	By a combination of the MNN1 deletion and the expression of a UDP-N-acetylglucosamine transporter, a strain forming complex-type glycans with a significantly improved homogeneity was obtained.	Polysaccharides	129-136	alpha-1,3-mannosyltransferase MNN1	Saccharomyces cerevisiae S288C	24-28
26997434-1	2016	The glycosyltransferases chondroitin sulfate synthase 1 (CHSY1) and exostoses-like 3 (EXTL3) specifically function in biosynthesis of the glycans chondroitin sulfate and heparan sulfate, respectively.	Polysaccharides	138-145	chondroitin sulfate synthase 1	Homo sapiens	57-62
26997434-1	2016	The glycosyltransferases chondroitin sulfate synthase 1 (CHSY1) and exostoses-like 3 (EXTL3) specifically function in biosynthesis of the glycans chondroitin sulfate and heparan sulfate, respectively.	Polysaccharides	138-145	exostosin like glycosyltransferase 3	Homo sapiens	68-84
26997434-1	2016	The glycosyltransferases chondroitin sulfate synthase 1 (CHSY1) and exostoses-like 3 (EXTL3) specifically function in biosynthesis of the glycans chondroitin sulfate and heparan sulfate, respectively.	Polysaccharides	138-145	exostosin like glycosyltransferase 3	Homo sapiens	86-91
26937552-7	2016	LpMab-17 recognized glycan-deficient PDPN in flow cytometry, indicating that the interaction between LpMab-17 and PDPN is independent of its glycosylation.	Polysaccharides	20-26	podoplanin	Homo sapiens	37-41
26850169-5	2016	For example, Fc regions with afucosylated glycans bind more tightly to FcgammaRIIIa than fucosylated Fc, and afucosylated Fcs exhibit enhanced ADCC activity in vivo and in vitro.	Polysaccharides	42-49	Fc gamma receptor IIIa	Homo sapiens	71-83
26566715-10	2016	The fluorescence and confocal microscopy study indicated that the densest and most uniformly coated surface with scFv was obtained at 37  C after oxidation of glycan chain.	Polysaccharides	159-165	immunglobulin heavy chain variable region	Homo sapiens	113-117
27001729-1	2016	A new class of broadly neutralizing antibodies (bNAbs) from HIV donors has been reported to target the glycans on gp120--a glycoprotein found on the surface of the virus envelope--thus renewing hope of developing carbohydrate-based HIV vaccines.	Polysaccharides	103-110	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	114-119
27209700-1	2016	One water-soluble polysaccharide (ASPS), with four molecular weight distributions of 74, 3.8, 4.5, 2.3 x 10(4) Da, was isolated from the root of Acanthopanax senticosus and the yield was 4.8% (w/w).	Polysaccharides	18-32	casein kinase 1 delta	Homo sapiens	34-38
26915800-0	2016	Astragalus polysaccharide upregulates hepcidin and reduces iron overload in mice via activation of p38 mitogen-activated protein kinase.	Polysaccharides	11-25	hepcidin antimicrobial peptide	Mus musculus	38-46
26794947-6	2016	In vitro study showed that both polysaccharides samples were able to stimulate the production of secretory molecules (NO, TNF-alpha and IL-6) of RAW264.7 murine macrophages in a dosage dependent manner.	Polysaccharides	32-47	tumor necrosis factor	Mus musculus	122-131
26794947-6	2016	In vitro study showed that both polysaccharides samples were able to stimulate the production of secretory molecules (NO, TNF-alpha and IL-6) of RAW264.7 murine macrophages in a dosage dependent manner.	Polysaccharides	32-47	interleukin 6	Mus musculus	136-140
30132596-5	2016	Results: LVMI,HMI were improved by total composition components and small polar iridoid glycosides components,and the content of ANP,ET-1 and AngIIwas decreased remarkably; The polysaccharide components could only decline the content of Ang II and ET-1.	Polysaccharides	177-191	natriuretic peptide A	Rattus norvegicus	129-132
30132596-5	2016	Results: LVMI,HMI were improved by total composition components and small polar iridoid glycosides components,and the content of ANP,ET-1 and AngIIwas decreased remarkably; The polysaccharide components could only decline the content of Ang II and ET-1.	Polysaccharides	177-191	angiotensinogen	Rattus norvegicus	237-243
26773038-9	2016	Glycan stabilization of the VWF A2 domain acts together with the Ca(2+)binding site and vicinal cysteine disulfide bond to control unfolding and ADAMTS13 proteolysis.	Polysaccharides	0-6	von Willebrand factor	Homo sapiens	28-31
26773038-9	2016	Glycan stabilization of the VWF A2 domain acts together with the Ca(2+)binding site and vicinal cysteine disulfide bond to control unfolding and ADAMTS13 proteolysis.	Polysaccharides	0-6	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	145-153
26915800-0	2016	Astragalus polysaccharide upregulates hepcidin and reduces iron overload in mice via activation of p38 mitogen-activated protein kinase.	Polysaccharides	11-25	mitogen-activated protein kinase 14	Mus musculus	99-102
26972002-0	2016	Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein.	Polysaccharides	48-54	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	81-102
27023496-7	2016	Infrared spectroscopy was used to characterize the major functional groups of GMP-1 and the results indicated that it was an acidic polysaccharide.	Polysaccharides	132-146	small ubiquitin like modifier 1	Homo sapiens	78-83
26985831-8	2016	These glycans on the pili are recognized by human dendritic cells via the C-type lectin receptor DC-SIGN, a key carbohydrate-dependent immune tailoring pattern recognition receptor.	Polysaccharides	6-13	CD209 molecule	Homo sapiens	97-104
27006456-4	2016	Genes for pneumococcal surface proteins replace the capsular polysaccharide (cps) locus in some NESp isolates, and these proteins aid in pneumococcal colonization and otitis media (OM).	Polysaccharides	61-75	nestin	Homo sapiens	96-100
26999763-2	2016	We show that the modification of Ovalbumin (OVA) with the glycan-structure Lewis(X) (Le(X)) re-directs OVA to the C-type lectin receptor MGL1.	Polysaccharides	58-64	fucosyltransferase 4	Mus musculus	85-90
26999763-2	2016	We show that the modification of Ovalbumin (OVA) with the glycan-structure Lewis(X) (Le(X)) re-directs OVA to the C-type lectin receptor MGL1.	Polysaccharides	58-64	C-type lectin domain family 10, member A	Mus musculus	137-141
27077082-4	2016	Data on glycan structure identification and relative abundance in ST3GAL4 overexpressing cells and respective mock control are presented.	Polysaccharides	8-14	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	66-73
26875935-3	2016	However, beta-glycosidases are not known to play a role in N- and O-glycan processing, although both glycans provide partial structures as substrates for beta-galactosidase and beta-N-acetylglucosaminidase in the Golgi apparatus of human cells.	Polysaccharides	101-108	galactosidase beta 1	Homo sapiens	154-172
26875935-3	2016	However, beta-glycosidases are not known to play a role in N- and O-glycan processing, although both glycans provide partial structures as substrates for beta-galactosidase and beta-N-acetylglucosaminidase in the Golgi apparatus of human cells.	Polysaccharides	101-108	O-GlcNAcase	Homo sapiens	177-205
26875935-6	2016	It is possible to predict a novel and important function in glycan processing of this beta-galactosidase, because various beta-galactosyl linkages in N- and O-glycans exist in Golgi apparatus.	Polysaccharides	60-66	galactosidase beta 1	Homo sapiens	86-104
27077082-7	2016	The data in this article is associated with the research article published in Biochim Biophys Acta "Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer" [1].	Polysaccharides	155-162	macrophage stimulating 1 receptor	Homo sapiens	180-183
26956484-7	2016	Knockdown of the sialyltransferase ST6GAL1 reduced alpha-2,6-linked sialic acids in the glycan structure of Orai1 and was associated with increased Ca(2+) entry in Jurkat T cells.	Polysaccharides	88-94	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	35-42
26668133-8	2016	The glycan binding site and the novel C-terminal tail of the mutant CALR proteins were required for TpoR activation.	Polysaccharides	4-10	calreticulin	Homo sapiens	68-72
26668133-8	2016	The glycan binding site and the novel C-terminal tail of the mutant CALR proteins were required for TpoR activation.	Polysaccharides	4-10	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	100-104
26755729-0	2016	Structures of Xenopus Embryonic Epidermal Lectin Reveal a Conserved Mechanism of Microbial Glycan Recognition.	Polysaccharides	91-97	intelectin 1 L homeolog	Xenopus laevis	22-48
26956484-7	2016	Knockdown of the sialyltransferase ST6GAL1 reduced alpha-2,6-linked sialic acids in the glycan structure of Orai1 and was associated with increased Ca(2+) entry in Jurkat T cells.	Polysaccharides	88-94	ORAI calcium release-activated calcium modulator 1	Homo sapiens	108-113
26855252-0	2016	Nonenzymatic Transglycosylation Reactions Induced by Roasting: New Insights from Models Mimicking Coffee Bean Regions with Distinct Polysaccharide Composition.	Polysaccharides	132-146	brain expressed associated with NEDD4 1	Homo sapiens	105-109
26948978-0	2016	Simultaneous expression and transportation of insulin by supramolecular polysaccharide nanocluster.	Polysaccharides	72-86	insulin	Homo sapiens	46-53
26418280-1	2016	Galectin-1 (gal-1), a member of the mammalian beta-galactoside-binding proteins, exerts biological effects by recognition of glycan ligands, including those involved in cell adhesion and growth regulation.	Polysaccharides	125-131	galectin 1	Homo sapiens	0-10
26418280-1	2016	Galectin-1 (gal-1), a member of the mammalian beta-galactoside-binding proteins, exerts biological effects by recognition of glycan ligands, including those involved in cell adhesion and growth regulation.	Polysaccharides	125-131	galectin 1	Homo sapiens	12-17
26855252-5	2016	These results have led to the conclusion that, depending on the distribution of the polysaccharides in the bean cell walls and the roasting conditions, different nonhybrid and hybrid structures can be formed during coffee roasting.	Polysaccharides	84-99	brain expressed associated with NEDD4 1	Homo sapiens	107-111
26678556-2	2016	Accordingly, the I-branching N-acetylglucosaminyltransferase (GCNT2) converts linear i-antigen to I-branching glycan, and its expression is associated with breast cancer progression.	Polysaccharides	110-116	glucosaminyl (N-acetyl) transferase 2 (I blood group)	Homo sapiens	62-67
26918909-0	2016	Pleurotus nebrodensis polysaccharide(PN50G) evokes A549 cell apoptosis by the ROS/AMPK/PI3K/AKT/mTOR pathway to suppress tumor growth.	Polysaccharides	22-36	AKT serine/threonine kinase 1	Homo sapiens	92-95
26918909-0	2016	Pleurotus nebrodensis polysaccharide(PN50G) evokes A549 cell apoptosis by the ROS/AMPK/PI3K/AKT/mTOR pathway to suppress tumor growth.	Polysaccharides	22-36	mechanistic target of rapamycin kinase	Homo sapiens	96-100
26897339-0	2016	C1 Inhibitor as a glycoprotein: The influence of polysaccharides on its function and autoantibody target.	Polysaccharides	49-64	serpin family G member 1	Homo sapiens	0-12
26537503-0	2016	Roles of glycans in interactions between gp120 and HIV broadly neutralizing antibodies.	Polysaccharides	9-16	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	41-46
26537503-3	2016	In this study, we have investigated the critical roles of glycans in interactions between HIV-1 gp120 and two broadly neutralizing antibodies PG9 (targeting V1/V2) and PGT128 (targeting V3) that are able to neutralize more than 70% of HIV-1 isolates.	Polysaccharides	58-65	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	96-101
26834178-3	2016	Expression of IRX14 was detected specifically in the seed coat epidermal cells, reaching peak expression at 13 days post-anthesis (DPA) when the accumulation of mucilage polysaccharides has ceased.	Polysaccharides	170-185	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	14-19
26631508-8	2016	LC-MS/MS analysis of O-glycans released from MUC7 by beta-elimination revealed that although patients had an increase in core 1 sulfation, the even larger reduction in sialylation resulted in a global decline of charged glycans.	Polysaccharides	23-30	mucin 7, secreted	Homo sapiens	45-49
26537503-5	2016	The simulation results show that the complex structures are stabilized by the glycans, and the multivalent interactions between the antibody and gp120 promote cooperativities to further enhance the binding.	Polysaccharides	78-85	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	145-150
26537503-6	2016	In the free gp120, the glycans increase the flexibility of the V1/V2 and V3 loops, which likely increases the entropy cost of the antibody recognition.	Polysaccharides	23-30	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	12-17
26743224-0	2016	TLR-4 may mediate signaling pathways of Astragalus polysaccharide RAP induced cytokine expression of RAW264.7 cells.	Polysaccharides	51-65	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	66-69
26893823-5	2016	RESULTS: We found that alpha2-6sialylated glycans in particular differed between elderly- and fetus-derived cells at early passage.	Polysaccharides	42-49	immunoglobulin binding protein 1	Homo sapiens	23-31
26892079-2	2016	Our previous studies have indentified scavenger receptor A (SR-A), especially SR-A type I (SR-AI), as prominent scavenger receptors on mediating oAbeta clearance by microglia while glycan moiety and scavenger receptor cysteine-rich (SRCR) domain may play the critical role.	Polysaccharides	181-187	macrophage scavenger receptor 1	Homo sapiens	60-64
26762799-2	2016	Some potent broadly neutralizing antibodies (bnAbs) such as 2G12, PG9, PG16, and PGTs can recognize the conserved glycan residues on Env.	Polysaccharides	114-120	endogenous retrovirus group K member 20	Homo sapiens	133-136
26851295-3	2016	These so-called "Fab glycans" are primarily highly processed complex-type biantennary N-glycans linked to N-glycosylation sites that emerge during somatic hypermutation.	Polysaccharides	21-28	FA complementation group B	Homo sapiens	17-20
27189177-4	2016	However, aberrant glycosylation alone is insufficient to induce renal injury: the participation of glycan-specific IgA and IgG autoantibodies that recognize the undergalactosylated IgA1 molecule is required.	Polysaccharides	99-105	immunoglobulin heavy constant alpha 1	Homo sapiens	181-185
26838726-4	2016	Studies with monoclonal antibodies (MAbs) to the pneumococcal capsular polysaccharide (PPS) of ST3 (PPS3) have shown that nonopsonic, as well as opsonic, antibodies can each protect mice against pneumonia and sepsis, but the effect of these types of MAbs on NP colonization is unknown.	Polysaccharides	71-85	matrix metallopeptidase 11	Mus musculus	95-98
26647853-2	2016	The biosensor exhibits three unique characteristics: (1) analysis of PSA with limit of detection (LOD) down to 4 aM; (2) analysis of the glycan part of PSA with LOD down to 4 aM level and; (3) both assays (i.e., PSA quantification and PSA glycoprofiling) can be performed on the same interface due to label-free analysis.	Polysaccharides	137-143	kallikrein related peptidase 3	Homo sapiens	152-155
26647853-2	2016	The biosensor exhibits three unique characteristics: (1) analysis of PSA with limit of detection (LOD) down to 4 aM; (2) analysis of the glycan part of PSA with LOD down to 4 aM level and; (3) both assays (i.e., PSA quantification and PSA glycoprofiling) can be performed on the same interface due to label-free analysis.	Polysaccharides	137-143	kallikrein related peptidase 3	Homo sapiens	152-155
26647853-2	2016	The biosensor exhibits three unique characteristics: (1) analysis of PSA with limit of detection (LOD) down to 4 aM; (2) analysis of the glycan part of PSA with LOD down to 4 aM level and; (3) both assays (i.e., PSA quantification and PSA glycoprofiling) can be performed on the same interface due to label-free analysis.	Polysaccharides	137-143	kallikrein related peptidase 3	Homo sapiens	152-155
26839969-3	2016	A polysaccharides depleted-water extract of P. lactiflora (PL-PP) increased LIF expression in human endometrial Ishikawa cells at non-cytotoxic doses.	Polysaccharides	2-17	pyridoxal (pyridoxine, vitamin B6) phosphatase	Mus musculus	59-64
26839969-3	2016	A polysaccharides depleted-water extract of P. lactiflora (PL-PP) increased LIF expression in human endometrial Ishikawa cells at non-cytotoxic doses.	Polysaccharides	2-17	LIF interleukin 6 family cytokine	Homo sapiens	76-79
26765751-4	2016	The versatility of this strategy was demonstrated by the rapid and highly efficient synthesis of NOTCH1 EGF12 concurrently having a beta-D-glucopyranose-initiated glycan (Xylalpha1   3Xylalpha1   3Glcbeta1  ) at Ser458 and alpha-L-fucopyranose-initiated glycan (Neu5Acalpha2   3Galbeta1   4GlcNAcbeta1   3Fucalpha1  ) at Thr466.	Polysaccharides	163-169	notch receptor 1	Homo sapiens	97-103
26765751-4	2016	The versatility of this strategy was demonstrated by the rapid and highly efficient synthesis of NOTCH1 EGF12 concurrently having a beta-D-glucopyranose-initiated glycan (Xylalpha1   3Xylalpha1   3Glcbeta1  ) at Ser458 and alpha-L-fucopyranose-initiated glycan (Neu5Acalpha2   3Galbeta1   4GlcNAcbeta1   3Fucalpha1  ) at Thr466.	Polysaccharides	254-260	notch receptor 1	Homo sapiens	97-103
26578817-5	2016	We herein report a thorough biophysical characterization of laforin-carbohydrate interaction using soluble glycans.	Polysaccharides	107-114	EPM2A glucan phosphatase, laforin	Homo sapiens	60-67
26687991-5	2016	Herein, we show that antibody blockade of Lewis X (Le(x)) displayed as terminal glycan residues on the PMN surface blocks chemotaxis and TEM while enhancing PMN-adhesive interactions with intestinal epithelia.	Polysaccharides	80-86	fucosyltransferase 4	Homo sapiens	51-56
26687991-6	2016	Unexpectedly, targeting of subterminal Le(x) residues within glycan chains had no effect on PMN migration or adhesive interactions.	Polysaccharides	61-67	fucosyltransferase 4	Homo sapiens	39-44
26578817-6	2016	We demonstrated an increased preference of laforin for the interaction with glycans with higher order of polymerization and confirmed the importance of tryptophan residues for glycan interaction.	Polysaccharides	76-83	EPM2A glucan phosphatase, laforin	Homo sapiens	43-50
26578817-6	2016	We demonstrated an increased preference of laforin for the interaction with glycans with higher order of polymerization and confirmed the importance of tryptophan residues for glycan interaction.	Polysaccharides	76-82	EPM2A glucan phosphatase, laforin	Homo sapiens	43-50
26578817-8	2016	The analysis of laforin-glycan interaction through the glycan side by saturation transfer difference (STD)-NMR has shown that the CBM-binding site can accommodate between 5 and 6 sugar units, which is in line with the recently obtained crystal structure of laforin.	Polysaccharides	24-30	EPM2A glucan phosphatase, laforin	Homo sapiens	16-23
26578817-8	2016	The analysis of laforin-glycan interaction through the glycan side by saturation transfer difference (STD)-NMR has shown that the CBM-binding site can accommodate between 5 and 6 sugar units, which is in line with the recently obtained crystal structure of laforin.	Polysaccharides	24-30	EPM2A glucan phosphatase, laforin	Homo sapiens	257-264
26429411-5	2016	Our results suggest that the extracellular Drgal1-L2 and Drgal3-L1 interact directly and in a carbohydrate-dependent manner with the IHNV glycosylated envelope and glycans on the epithelial cell surface, significantly reducing viral adhesion.	Polysaccharides	164-171	lectin, galactoside-binding, soluble, 2a	Danio rerio	43-52
26900446-0	2016	Deciphering the Mode of Action of the Processive Polysaccharide Modifying Enzyme Dermatan Sulfate Epimerase 1 by Hydrogen-Deuterium Exchange Mass Spectrometry.	Polysaccharides	49-63	dermatan sulfate epimerase	Homo sapiens	81-109
26900446-4	2016	Using recombinant DS-epi1 as a model enzyme, we describe a tandem mass spectrometry-based method to study the mode of action of polysaccharide processing enzymes.	Polysaccharides	128-142	dermatan sulfate epimerase	Homo sapiens	18-25
26514868-12	2016	The high affinity and exclusive specificity of CSL towards alpha1-6 linkage of core fucosylated glycans compared to other fucose specific lectins, makes it a promising molecule that needs to be further explored for its application in the diagnosis of gastrointestinal cancer.	Polysaccharides	96-103	adrenoceptor alpha 1D	Homo sapiens	59-67
26787547-3	2016	Moreover, the reduced catalytic activity of the Asn177 mutant that is modified by glycan moieties in the wild-type enzyme indicates a functional relevance of CYP2W1 glycosylation.	Polysaccharides	82-88	cytochrome P450 family 2 subfamily W member 1	Homo sapiens	158-164
26411873-3	2016	We unexpectedly discovered that hSiglec-9 also specifically binds high molecular weight hyaluronan (HMW-HA), another ubiquitous host glycan, through a region of its terminal Ig-like V-set domain distinct from the Sia-binding site.	Polysaccharides	133-139	sialic acid binding Ig like lectin 9	Homo sapiens	32-41
26411873-7	2016	KEY MESSAGE: HMW-HA is the first example of a non-sialic acid containing glycan to be recognized by CD33-related Siglecs.	Polysaccharides	73-79	CD33 molecule	Homo sapiens	100-104
26411873-1	2016	UNLABELLED: Inhibitory CD33-related Siglec receptors regulate immune cell activation upon engaging ubiquitous sialic acids (Sias) on host cell surface glycans.	Polysaccharides	151-158	CD33 molecule	Homo sapiens	23-27
26411873-9	2016	Group A Streptococcus exploits hSiglec-9 recognition via its polysaccharide HMW-HA capsule to subvert neutrophil killing.	Polysaccharides	61-75	sialic acid binding Ig like lectin 9	Homo sapiens	31-40
26051019-4	2016	Here we developed a novel quantitative method for measurement of disease-specific GAGs based on the analysis of 2-sulfoiduronic acid levels derived from the non-reducing terminal end of the polysaccharides by using recombinant human IDS (rhIDS) and recombinant human iduronidase (rhIDUA).	Polysaccharides	190-205	iduronate 2-sulfatase	Homo sapiens	233-236
26720211-6	2016	Levels of cell wall polysaccharides per hypocotyl, particularly cellulose, increased in anl2.	Polysaccharides	20-35	Homeobox-leucine zipper family protein / lipid-binding START domain-containing protein	Arabidopsis thaliana	88-92
26383868-3	2016	Glycosylation is one of the most abundant posttranslational modifications of animal proteins and through recent advances in our understanding of protein-glycan interactions, the functional roles of SLC glycosylation are slowly emerging.	Polysaccharides	153-159	C-C motif chemokine ligand 21	Homo sapiens	198-201
26823113-1	2016	Two non-human glycan epitopes, galactose-alpha-1,3-galactose (alpha-gal) and Neu5Gc-alpha-2-6-galactose (Neu5Gc) have been shown to be antigenic when attached to Fab oligosaccharides of monoclonal antibodies (mAbs) , while alpha-gal attached to Fc glycans was not.	Polysaccharides	14-20	FA complementation group B	Homo sapiens	162-165
26828567-2	2016	Galectin-4 is expressed mainly in the alimentary tract and is proposed to function as a lipid raft and adherens junction stabilizer by its glycan cross-linking capacity.	Polysaccharides	139-145	galectin 4	Homo sapiens	0-10
26432949-3	2016	The functional data available for this class of proteins suggest that the wide spectrum of cellular activities reported for Gal4 relies on distinct glycan specificity and structural characteristics of its two carbohydrate recognition domains.	Polysaccharides	148-154	galectin 4	Homo sapiens	124-128
26822404-9	2016	Complementation assays and glycan analysis in yeast alg3 mutant confirmed the reduced enzymatic function of the proteins encoded by the cce2/cce3 alleles - leading to accumulation of M5(ER), the immature five mannose-containing oligosaccharide structure found in the ER.	Polysaccharides	27-33	dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	52-56
26572439-7	2016	Furthermore, this polysaccharide promoted the activation of nuclear factor kappa B in RAW264 cells, indicating that it stimulates the induction of various cytokines in macrophages through the TLR4 signaling pathway.	Polysaccharides	18-32	toll-like receptor 4	Mus musculus	192-196
26683093-5	2016	The conjugation approach allowed the controlled attachment of doxorubicin through an acid-labile hydrazone linkage, an Alexa Fluor dye through an amide bond, and a glycan-based ligand for the cell surface receptor CD22 of B-cells using strain promoted azide-alkyne cycloaddition.	Polysaccharides	164-170	CD22 molecule	Homo sapiens	214-218
26795117-7	2016	Therefore, we report for the first time two chito-specific lectins specifically binding to tumor glycans; they can be considered to be a class of molecules with antitumor activity against pancreatic cancer cells mediated through caspase dependent mitochondrial apoptotic pathway.	Polysaccharides	97-104	caspase 9	Homo sapiens	229-236
27109156-9	2016	ROS-centered pathways (e.g. mitochondrial autophagy, MAPK and JNK) and transcription factor-related pathways (e.g. NF-[Formula: see text]B and HIF) are frequently utilized by these polysaccharides with or without the further involvement of inflammatory and death receptor pathways.	Polysaccharides	181-196	mitogen-activated protein kinase 8	Homo sapiens	62-65
26766578-12	2016	Together the findings suggest that both viral and host factors are critical for the development of bnAbs and that the HIV Env N332-glycan supersite may be a favorable target for vaccine design.	Polysaccharides	131-137	endogenous retrovirus group K member 20	Homo sapiens	122-125
26582203-0	2016	A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity.	Polysaccharides	9-15	kallikrein related peptidase 2	Homo sapiens	40-70
26582203-7	2016	Although glyco-KLK2 has a considerably lower catalytic efficiency than glycan-free KLK2 toward peptidic substrates with P2-Phe, the situation was reverted toward protein substrates, such as glyco-pro-KLK2 itself.	Polysaccharides	71-77	kallikrein related peptidase 2	Homo sapiens	15-19
26582203-7	2016	Although glyco-KLK2 has a considerably lower catalytic efficiency than glycan-free KLK2 toward peptidic substrates with P2-Phe, the situation was reverted toward protein substrates, such as glyco-pro-KLK2 itself.	Polysaccharides	71-77	kallikrein related peptidase 2	Homo sapiens	83-87
26582203-7	2016	Although glyco-KLK2 has a considerably lower catalytic efficiency than glycan-free KLK2 toward peptidic substrates with P2-Phe, the situation was reverted toward protein substrates, such as glyco-pro-KLK2 itself.	Polysaccharides	71-77	kallikrein related peptidase 2	Homo sapiens	83-87
26582203-10	2016	Also, the cleavage pattern and kinetics in autolytic inactivation of both KLK2 variants can be explained by a shift of the target sites due to the presence of the glycan.	Polysaccharides	163-169	kallikrein related peptidase 2	Homo sapiens	74-78
26582205-1	2016	We previously showed that galectin-9 suppresses degranulation of mast cells through protein-glycan interaction with IgE.	Polysaccharides	92-98	galectin 9	Homo sapiens	26-36
26582205-2	2016	To elucidate the mechanism of the interaction in detail, we focused on identification and structural analysis of IgE glycans responsible for the galectin-9-induced suppression using mouse monoclonal IgE (TIB-141).	Polysaccharides	117-124	galectin 9	Homo sapiens	145-155
26727976-12	2016	Dectin-2-dependent IL-12 production may contribute to IFN-gamma synthesis and subsequent production of serotype-specific anti-capsular polysaccharide IgG after S. pneumoniae infection, which may promote S. pneumoniae bacterial opsonization for engulfment.	Polysaccharides	135-149	C-type lectin domain family 4, member n	Mus musculus	0-8
30979105-1	2016	The aim of the study was to produce 3D sponges based on enzymatically modified lysozyme selected polysaccharides and assess their physicochemical properties.	Polysaccharides	97-112	lysozyme	Homo sapiens	79-87
26286194-5	2016	The combined CSDB includes information on bacterial and archaeal glycans and derivatives (the coverage is close to complete), as well as on plant and fungal glycans and glycoconjugates (almost all structures published up to 1998).	Polysaccharides	65-72	Y-box binding protein 1	Homo sapiens	13-17
26286194-9	2016	CSDB provides additional services for simulation of (1)H, (13)C and 2D NMR spectra of saccharides, NMR-based structure prediction, glycan-based taxon clustering and other.	Polysaccharides	131-137	Y-box binding protein 1	Homo sapiens	0-4
26760037-4	2016	Using inhibitors of glycosylation we found that both, binding of Gal-3 to the RPE cell surface and Gal-3-mediated inhibition of RPE attachment and spreading, strongly depend on the interaction of Gal-3 with tri- or tetra-antennary complex type N-glycans and sialylation of glycans but not on complex-type O-glycans.	Polysaccharides	246-253	galectin 3	Homo sapiens	65-70
26760037-4	2016	Using inhibitors of glycosylation we found that both, binding of Gal-3 to the RPE cell surface and Gal-3-mediated inhibition of RPE attachment and spreading, strongly depend on the interaction of Gal-3 with tri- or tetra-antennary complex type N-glycans and sialylation of glycans but not on complex-type O-glycans.	Polysaccharides	246-253	galectin 3	Homo sapiens	99-104
26760037-4	2016	Using inhibitors of glycosylation we found that both, binding of Gal-3 to the RPE cell surface and Gal-3-mediated inhibition of RPE attachment and spreading, strongly depend on the interaction of Gal-3 with tri- or tetra-antennary complex type N-glycans and sialylation of glycans but not on complex-type O-glycans.	Polysaccharides	246-253	galectin 3	Homo sapiens	99-104
27109156-10	2016	Some of the polysaccharides may also influence tumorigenic pathways, such as Wnt and p53 to play their anti-tumor roles.	Polysaccharides	12-27	tumor protein p53	Homo sapiens	85-88
29533555-2	2016	The in vitro NF contact with PS resulted in significant changes in the functional activity of NF, evident from higher density of molecules CD69, CD14, CD11b on the cell membranes with simultaneous lowering of that of CD62L and increased phagocytic and bactericidal activity of NF.	Polysaccharides	29-31	CD69 molecule	Homo sapiens	139-143
26098591-8	2016	Genes up-regulated by TGF-beta1 and reversed by PGE2 were enriched in annotations for Cell Adhesion, Contractile Fiber, and Actin Binding, whereas genes down-regulated by TGF-beta1 but subsequently reversed by PGE2 were enriched in annotations for Glycoprotein, Polysaccharide Binding, and Regulation of Cell Migration.	Polysaccharides	262-276	transforming growth factor beta 1	Homo sapiens	22-31
26098591-8	2016	Genes up-regulated by TGF-beta1 and reversed by PGE2 were enriched in annotations for Cell Adhesion, Contractile Fiber, and Actin Binding, whereas genes down-regulated by TGF-beta1 but subsequently reversed by PGE2 were enriched in annotations for Glycoprotein, Polysaccharide Binding, and Regulation of Cell Migration.	Polysaccharides	262-276	transforming growth factor beta 1	Homo sapiens	171-180
29533555-2	2016	The in vitro NF contact with PS resulted in significant changes in the functional activity of NF, evident from higher density of molecules CD69, CD14, CD11b on the cell membranes with simultaneous lowering of that of CD62L and increased phagocytic and bactericidal activity of NF.	Polysaccharides	29-31	CD14 molecule	Homo sapiens	145-149
29533555-2	2016	The in vitro NF contact with PS resulted in significant changes in the functional activity of NF, evident from higher density of molecules CD69, CD14, CD11b on the cell membranes with simultaneous lowering of that of CD62L and increased phagocytic and bactericidal activity of NF.	Polysaccharides	29-31	integrin subunit alpha M	Homo sapiens	151-156
29533555-2	2016	The in vitro NF contact with PS resulted in significant changes in the functional activity of NF, evident from higher density of molecules CD69, CD14, CD11b on the cell membranes with simultaneous lowering of that of CD62L and increased phagocytic and bactericidal activity of NF.	Polysaccharides	29-31	selectin L	Homo sapiens	217-222
26243235-10	2016	IgM antibodies to the polysaccharide capsule and total IgE were more abundant in the sera from C57BL/6J, confirming that these animals present a Th2-type response.	Polysaccharides	22-36	heart and neural crest derivatives expressed 2	Mus musculus	145-148
27644624-2	2016	Polysaccharide extracted from polygonatum can selectively inhibit the growth of prostate-CAFs (&lt;.001) without inhibiting the growth of normal broblasts (NAFs).	Polysaccharides	0-14	T-box transcription factor 1	Homo sapiens	89-93
27644624-3	2016	Polysaccharides from polygonatum stimulate autophagy of prostate-CAFs.	Polysaccharides	0-15	T-box transcription factor 1	Homo sapiens	65-69
27644624-6	2016	Finally, polysaccharide from polygonatum treatment significantly increased the activation of Beclin-1 and LC3, key autophagy proteins.	Polysaccharides	9-23	beclin 1	Homo sapiens	93-101
27644624-6	2016	Finally, polysaccharide from polygonatum treatment significantly increased the activation of Beclin-1 and LC3, key autophagy proteins.	Polysaccharides	9-23	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	106-109
27644624-7	2016	Polysaccharides from polygonatum stimulate autophagy of prostate-CAFs and inhibits prostate-CAF growth, indicating that a novel anti-cancer strategy involves inhibiting the growth of prostate- CAFs.	Polysaccharides	0-15	T-box transcription factor 1	Homo sapiens	65-69
27644624-7	2016	Polysaccharides from polygonatum stimulate autophagy of prostate-CAFs and inhibits prostate-CAF growth, indicating that a novel anti-cancer strategy involves inhibiting the growth of prostate- CAFs.	Polysaccharides	0-15	T-box transcription factor 1	Homo sapiens	193-197
26467158-11	2016	These results highlight the role of bisecting GlcNAc in oxidative stress-induced BACE1 expression and offer a novel glycan-targeted strategy for suppressing Abeta generation.	Polysaccharides	116-122	beta-site APP cleaving enzyme 1	Mus musculus	81-86
26427558-6	2016	Biosynthesis of PLM beta-Mans involves two beta-1,2 mannosyltransferases (Bmts) that initiate (Bmt5) and elongate (Bmt6) the glycan chains.	Polysaccharides	125-131	25S rRNA (uracil2634-N3)-methyltransferase	Saccharomyces cerevisiae S288C	95-99
28791106-4	2016	By controlling the size of the substrate probe to match the expression zone of the protein-specific glycan, an efficient SERS signal can be generated.	Polysaccharides	100-106	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	121-125
27373624-1	2016	In the endoplasmic reticulum (ER), uridine 5"-diphosphate-glucose: glycoprotein glucosyltransferase 1 (UGGT1) recognizes misfolded glycoproteins and transfers a glucose residue to the specific non-reducing end of high-mannose-type glycans.	Polysaccharides	231-238	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	35-101
27373624-1	2016	In the endoplasmic reticulum (ER), uridine 5"-diphosphate-glucose: glycoprotein glucosyltransferase 1 (UGGT1) recognizes misfolded glycoproteins and transfers a glucose residue to the specific non-reducing end of high-mannose-type glycans.	Polysaccharides	231-238	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	103-108
27348128-4	2016	The various Epos, e.g. recombinant human (rh)Epo and (epoetin), and their long-acting analogues can be misused by cheating athletes, but the drugs are detectable by chemical tests, because their glycan isoform structures differ from those of endogenous Epo.	Polysaccharides	195-201	erythropoietin	Homo sapiens	12-15
27065039-1	2016	Glycans of prostate-specific antigen (PSA) in prostate cancer were found to be different from that in benign disease.	Polysaccharides	0-7	kallikrein related peptidase 3	Homo sapiens	11-42
27348128-4	2016	The various Epos, e.g. recombinant human (rh)Epo and (epoetin), and their long-acting analogues can be misused by cheating athletes, but the drugs are detectable by chemical tests, because their glycan isoform structures differ from those of endogenous Epo.	Polysaccharides	195-201	erythropoietin	Homo sapiens	54-61
26522247-1	2016	A polysaccharide termed Se-GP11 was extracted and purified from Se-enriched Grifola frondosa in our previous study.	Polysaccharides	2-16	S100 calcium binding protein A10	Homo sapiens	27-31
26646771-0	2016	Binding of polysaccharides to human galectin-3 at a noncanonical site in its carbohydrate recognition domain.	Polysaccharides	11-26	galectin 3	Homo sapiens	36-46
26646771-4	2016	Overall, we found that these polysaccharides with a larger carbohydrate footprint interact primarily with a noncanonical carbohydrate-binding site on the F-face of the Gal-3 CRD beta-sandwich, and to a less extent, if at all, with the canonical carbohydrate-binding site on the S-face.	Polysaccharides	29-44	galectin 3	Homo sapiens	168-173
26646771-6	2016	Significant Gal-3 resonance broadening observed during polysaccharide titrations indicates that interactions occur in the intermediate exchange regime, and analysis of these data allows estimation of affinities and stoichiometries that range from 4 x 10(4) to 12 x 10(4) M(-1) per site and multiple sites per polysaccharide, respectively.	Polysaccharides	55-69	galectin 3	Homo sapiens	12-17
26646771-6	2016	Significant Gal-3 resonance broadening observed during polysaccharide titrations indicates that interactions occur in the intermediate exchange regime, and analysis of these data allows estimation of affinities and stoichiometries that range from 4 x 10(4) to 12 x 10(4) M(-1) per site and multiple sites per polysaccharide, respectively.	Polysaccharides	309-323	galectin 3	Homo sapiens	12-17
26347576-5	2016	First, C1INH bound to glycan moieties within P. falciparum glycosylphosphatidylinositol (PfGPI) molecules on the parasite surface, inhibiting parasite RBC invasion and proinflammatory cytokine production by parasite-stimulated monocytes in vitro and reducing parasitemia in a rodent model of experimental cerebral malaria (ECM) in vivo.	Polysaccharides	22-28	serpin family G member 1	Homo sapiens	7-12
26454111-0	2016	Hepatoprotective effects of polysaccharide isolated from Agaricus bisporus industrial wastewater against CCl4-induced hepatic injury in mice.	Polysaccharides	28-42	chemokine (C-C motif) ligand 4	Mus musculus	105-109
28094746-3	2016	This study was undertaken to investigate the effect of polysaccharide from C. militaris (PCM) on physical fatigue induced in animals through a forced swimming test.	Polysaccharides	55-69	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	89-92
26454111-7	2016	Additionally, the potential hepatoprotective activities of these polysaccharides against CCl4-induced hepatic injury in mice were studied.	Polysaccharides	65-80	chemokine (C-C motif) ligand 4	Mus musculus	89-93
26454111-9	2016	These results indicate that these two polysaccharides had protective effects on acute hepatic injury induced by CCl4 in mice and suggest that the polysaccharides extracted from A. bisporus industrial wastewater might have potential in therapeutics of acute hepatic injury.	Polysaccharides	38-53	chemokine (C-C motif) ligand 4	Mus musculus	112-116
26454111-9	2016	These results indicate that these two polysaccharides had protective effects on acute hepatic injury induced by CCl4 in mice and suggest that the polysaccharides extracted from A. bisporus industrial wastewater might have potential in therapeutics of acute hepatic injury.	Polysaccharides	146-161	chemokine (C-C motif) ligand 4	Mus musculus	112-116
26478094-3	2016	The polysaccharide, AMPS-a, was obtained from the ethanol-extracted debris of Flos A. manihot by successive purification through DEAE-cellulose-52 and Sephadex G-100 column.	Polysaccharides	4-18	adenylosuccinate lyase	Homo sapiens	20-24
28008810-0	2016	A Polysaccharide from the Culinary-Medicinal Mushroom Pholiota nameko (Agaricomycetes) Inhibits the NF-kappaB Pathway in Dendritic Cells Through the TLR2 Receptor.	Polysaccharides	2-16	toll-like receptor 2	Mus musculus	149-153
26627984-6	2016	Interestingly, an increased addition of bisecting GlcNAc and alpha(1-3)-galactose residues to the Fc glycan was observed for HEK293-derived and J558L-derived IgG1 F243A, respectively.	Polysaccharides	101-107	LOC105243590	Mus musculus	158-162
27082983-8	2016	Furthermore, SAG binding to DC-SIGN or Langerin prevented binding to the micro-organisms Candida albicans and Escherichia coli which express mannose and fucose-containing glycan structures.	Polysaccharides	171-177	deleted in malignant brain tumors 1	Homo sapiens	13-16
27082983-8	2016	Furthermore, SAG binding to DC-SIGN or Langerin prevented binding to the micro-organisms Candida albicans and Escherichia coli which express mannose and fucose-containing glycan structures.	Polysaccharides	171-177	CD207 molecule	Homo sapiens	39-47
26566837-6	2016	Analysis of cell wall polysaccharide composition of Slexp1-7_Q213Stop mutant pointed out significant differences for uronic acid, neutral sugar and total sugar contents.	Polysaccharides	22-36	expansin	Solanum lycopersicum	52-58
26537799-10	2016	Finally, correlation of CRC cell line glycosylation features with cancer cell markers and phenotypes revealed an association between highly fucosylated glycans and CDX1 and/or villin mRNA expression that both correlate with cell differentiation.	Polysaccharides	152-159	caudal type homeobox 1	Homo sapiens	164-168
25963228-0	2016	Cryptoporus volvatus polysaccharides attenuate LPS-induced expression of pro-inflammatory factors via the TLR2 signaling pathway in human alveolar epithelial cells.	Polysaccharides	21-36	toll like receptor 2	Homo sapiens	106-110
26566837-9	2016	These SlExp1 mutants represent good tools for breeding long shelf life tomato lines with contrasted fruit texture as well as for the understanding of the cell wall polysaccharide assembly dynamics in fleshy fruits.	Polysaccharides	164-178	expansin	Solanum lycopersicum	6-12
26494508-0	2015	Protective effects of sea buckthorn polysaccharide extracts against LPS/d-GalN-induced acute liver failure in mice via suppressing TLR4-NF-kappaB signaling.	Polysaccharides	36-50	toll-like receptor 4	Mus musculus	131-135
26494508-0	2015	Protective effects of sea buckthorn polysaccharide extracts against LPS/d-GalN-induced acute liver failure in mice via suppressing TLR4-NF-kappaB signaling.	Polysaccharides	36-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	136-145
26432866-3	2015	beta-Glucans are a diverse group of polysaccharides previously suggested to serve as fungal ligands for SP-D.	Polysaccharides	36-51	surfactant associated protein D	Mus musculus	104-108
26507663-1	2015	CD22 is an inhibitory B-cell co-receptor whose function is modulated by sialic acid (Sia)-bearing glycan ligands.	Polysaccharides	98-104	CD22 molecule	Homo sapiens	0-4
26507663-2	2015	Glycan remodeling in the germinal center (GC) alters CD22 ligands, with as yet no ascribed biological consequence.	Polysaccharides	0-6	CD22 molecule	Homo sapiens	53-57
26507663-4	2015	The conserved modulation of CD22 ligands on GC B-cells is striking because high affinity glycan ligands of CD22 are species-specific.	Polysaccharides	89-95	CD22 molecule	Homo sapiens	28-32
26507663-4	2015	The conserved modulation of CD22 ligands on GC B-cells is striking because high affinity glycan ligands of CD22 are species-specific.	Polysaccharides	89-95	natriuretic peptide receptor 2	Homo sapiens	44-48
26507663-4	2015	The conserved modulation of CD22 ligands on GC B-cells is striking because high affinity glycan ligands of CD22 are species-specific.	Polysaccharides	89-95	CD22 molecule	Homo sapiens	107-111
26507663-10	2015	Human naive and memory B-cells express sulfated glycans as high affinity CD22 ligands, which are lost on GC B-cells.	Polysaccharides	48-55	CD22 molecule	Homo sapiens	73-77
26507663-11	2015	In mice, Neu5Gc-containing glycans serve as high affinity CD22 ligands that are replaced by Neu5Ac-containing glycans on GC B-cells.	Polysaccharides	27-34	CD22 antigen	Mus musculus	58-62
26507663-11	2015	In mice, Neu5Gc-containing glycans serve as high affinity CD22 ligands that are replaced by Neu5Ac-containing glycans on GC B-cells.	Polysaccharides	27-34	natriuretic peptide receptor 2	Mus musculus	121-125
26507663-11	2015	In mice, Neu5Gc-containing glycans serve as high affinity CD22 ligands that are replaced by Neu5Ac-containing glycans on GC B-cells.	Polysaccharides	110-117	natriuretic peptide receptor 2	Mus musculus	121-125
26257188-5	2015	Under optimal experimental conditions, amperometric response changes were used to detect alpha2,6-sialylated glycans with a broad linear range of 10 fg mL(-1) -1 mug mL(-1) and a low detection limit of 3 fg mL(-1) (S/N=3).	Polysaccharides	109-116	skull morphology 1	Mus musculus	152-161
26142157-8	2015	These results suggest that ADC-dependent Put accumulation plays important roles in providing protection against Al toxicity in wheat plants through decreasing cell wall polysaccharides and increasing the degree of pectin methylation, thus decreasing Al retention in the cell walls.	Polysaccharides	169-184	arginine decarboxylase 1	Triticum aestivum	27-30
26318196-0	2015	Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets.	Polysaccharides	38-45	LOC100508689	Homo sapiens	32-37
26459889-3	2015	Increased biofilm formation by hVISA may be mediated by FnbA- and polysaccharide intercellular adhesin-dependent pathways, and upregulation of atlA and sarA may also contribute to enhanced biofilm formation by hVISA upon prolonged exposure to vancomycin.	Polysaccharides	66-80	mitochondrial antiviral signaling protein	Homo sapiens	31-36
26378150-9	2015	In addition NanS can act upon complex N-glycans released from a glycoprotein [erythropoietin (EPO)], bovine submaxillary mucin and oral epithelial cell-bound glycans.	Polysaccharides	40-47	N-acetylneuraminate synthase	Bos taurus	12-16
26378150-9	2015	In addition NanS can act upon complex N-glycans released from a glycoprotein [erythropoietin (EPO)], bovine submaxillary mucin and oral epithelial cell-bound glycans.	Polysaccharides	40-47	erythropoietin	Bos taurus	78-92
26378150-9	2015	In addition NanS can act upon complex N-glycans released from a glycoprotein [erythropoietin (EPO)], bovine submaxillary mucin and oral epithelial cell-bound glycans.	Polysaccharides	40-47	erythropoietin	Bos taurus	94-97
26378150-9	2015	In addition NanS can act upon complex N-glycans released from a glycoprotein [erythropoietin (EPO)], bovine submaxillary mucin and oral epithelial cell-bound glycans.	Polysaccharides	40-47	mucin 1, cell surface associated	Bos taurus	121-126
26318196-7	2015	Finally, this review discusses the scope of mucin glycan epitopes as potential diagnostic and therapeutic targets.	Polysaccharides	50-56	LOC100508689	Homo sapiens	44-49
26540494-2	2015	Compounds that interact with these high-mannose type glycans may disturb the interaction between gp120 and its (co)receptors and are considered potential anti-HIV agents.	Polysaccharides	53-60	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	97-102
26636129-6	2015	Adapted regions containing bony fingers exhibited woven bone-like architecture and these regions rich in biglycan (BGN) and bone sialoprotein (BSP) also contained high-molecular weight polysaccharides predominantly at the site of polarized bone growth.	Polysaccharides	185-200	integrin-binding sialoprotein	Rattus norvegicus	143-146
26321244-1	2015	Fucosylated glycans synthesized by alpha1,3/4-fucosyltransferase (FUT3) enzyme play an important role in breast cancer prognosis and metastasis, being involved in the binding of circulating tumor cells to the endothelium and being related to tumor stage, metastatic potential and chemoresistance.	Polysaccharides	12-19	fucosyltransferase 3 (Lewis blood group)	Homo sapiens	66-70
26318439-2	2015	Through computerized structural analysis, we found a marine-derived polysaccharide, holothurian glycosaminoglycan (hGAG), behaved as a ligand-competitive inhibitor of P-selectin, indicating its potential to disrupt the binding of P-selectin to cell surface receptor and activation of downstream regulators of tumor cell migration.	Polysaccharides	68-82	selectin, platelet	Mus musculus	167-177
26306634-7	2015	The results provide the structural basis for a model of heparin/heparan sulfate binding to TGF-beta1 and demonstrate that the features in the polysaccharide required for binding are not identical to those required for sustaining the signaling by TGF-beta1 in hMSCs.	Polysaccharides	142-156	transforming growth factor beta 1	Homo sapiens	91-100
26231935-0	2015	Three N-Glycosylation Sites of Human Acetylcholinesterase Shares Similar Glycan Composition.	Polysaccharides	73-79	acetylcholinesterase (Cartwright blood group)	Homo sapiens	37-57
26278982-7	2015	There is also a common equine polysaccharide storage myopathy belonging to this group of diseases involving the GYS1 gene.	Polysaccharides	30-44	glycogen synthase 1	Equus caballus	112-116
26342810-2	2015	In this study, we used multiple lectin assays to analyze glycan patterns of serum GP73 and evaluated its diagnostic value for distinguishing hepatocellular carcinoma (HCC) from liver cirrhosis (LC).	Polysaccharides	57-63	golgi membrane protein 1	Homo sapiens	82-86
26342810-3	2015	Firstly, Antibody overlay lectin microarray and lectin blot were performed to observe altered glycans of GP73.	Polysaccharides	94-101	golgi membrane protein 1	Homo sapiens	105-109
26497328-11	2015	Therefore, interactions between integrins and galectin-3 may be mediated through beta-galactose that is linked to glycans of integrins.	Polysaccharides	114-121	galectin 3	Homo sapiens	46-56
26407826-4	2015	Mutation of all the three glcyans rendered a CBA-sensitive T/F Env largely resistant to GRFT, indicating that the sensitivity of T/F Env to GRFT is mainly determined by glycans at 295, 339 and 448.	Polysaccharides	169-176	endogenous retrovirus group K member 20	Homo sapiens	133-136
26231935-8	2015	Although the three glycosylation sites within AChE sequence have different extent in affecting the enzymatic activity, their glycan compositions are very similar.	Polysaccharides	125-131	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-50
25358602-0	2015	Low fucose containing bacterial polysaccharide facilitate mitochondria-dependent ROS-induced apoptosis of human lung epithelial carcinoma via controlled regulation of MAPKs-mediated Nrf2/Keap1 homeostasis signaling.	Polysaccharides	32-46	NFE2 like bZIP transcription factor 2	Homo sapiens	182-186
25358602-0	2015	Low fucose containing bacterial polysaccharide facilitate mitochondria-dependent ROS-induced apoptosis of human lung epithelial carcinoma via controlled regulation of MAPKs-mediated Nrf2/Keap1 homeostasis signaling.	Polysaccharides	32-46	kelch like ECH associated protein 1	Homo sapiens	187-192
25358602-9	2015	Simultaneously, during apoptosis, the ROS-mediated stress as well as activated MAPKs triggered nuclear translocation of transcription factors like nuclear factor (erythroid-derived)-like 2 (Nrf2) and promoted further transcription of downstream cytoprotective genes, which somehow perturbed the chemotherapeutic efficacy of the polysaccharide, although using CuPP, a chemical inhibitor of HO-1, apoptosis increased significantly (P &lt; 0.05).	Polysaccharides	328-342	NFE2 like bZIP transcription factor 2	Homo sapiens	190-194
26318439-2	2015	Through computerized structural analysis, we found a marine-derived polysaccharide, holothurian glycosaminoglycan (hGAG), behaved as a ligand-competitive inhibitor of P-selectin, indicating its potential to disrupt the binding of P-selectin to cell surface receptor and activation of downstream regulators of tumor cell migration.	Polysaccharides	68-82	selectin, platelet	Mus musculus	230-240
26627256-8	2015	General inhibitors of sialyltranserases (STs), the enzymes that transfer sialic acid residues onto terminal positions of glycans, suppressed extrasialylation of PrP(Sc).	Polysaccharides	121-128	prion protein	Mus musculus	161-164
26421933-4	2015	Tg contains covalently linked complex-type glycans that can serve as binding epitopes of Gal-3.	Polysaccharides	43-50	galectin 3	Homo sapiens	89-94
26344289-1	2015	A polysaccharide CP1-1 was isolated and purified from Celosia cristata.	Polysaccharides	2-16	cleft palate 2	Mus musculus	17-22
28955811-3	2016	The present work evaluated the involvement of glycans in hCES2 activity and thermo stability in an attempt to find alternative active forms of the enzyme that might be adequate for structure elucidation.	Polysaccharides	46-53	carboxylesterase 2	Homo sapiens	57-62
25771993-3	2015	Elastin and elastin-like peptides can also be modified or blended with other natural or synthetic moieties, including peptides, proteins, polysaccharides, and polymers, to augment existing capabilities or confer additional architectural and biofunctional features to compositionally pure materials.	Polysaccharides	138-153	elastin	Homo sapiens	0-7
25771993-3	2015	Elastin and elastin-like peptides can also be modified or blended with other natural or synthetic moieties, including peptides, proteins, polysaccharides, and polymers, to augment existing capabilities or confer additional architectural and biofunctional features to compositionally pure materials.	Polysaccharides	138-153	elastin	Homo sapiens	12-19
26420485-11	2015	These data suggest that glycosylation of RDS is required for RDS function or stability in cones, a difference that may be due to extracellular versus intradiscal localization of the RDS glycan in cones versus rods.	Polysaccharides	186-192	peripherin 2	Mus musculus	41-44
26612738-0	2015	Polysaccharide-induced apoptosis in H22 cells through G2/M arrest and BCL2/BAX caspase-activated Fas pathway.	Polysaccharides	0-14	B cell leukemia/lymphoma 2	Mus musculus	70-74
26885153-0	2015	Astragalus polysaccharide improves cardiac function in doxorubicin-induced cardiomyopathy through ROS-p38 signaling.	Polysaccharides	11-25	mitogen activated protein kinase 14	Rattus norvegicus	102-105
26420485-11	2015	These data suggest that glycosylation of RDS is required for RDS function or stability in cones, a difference that may be due to extracellular versus intradiscal localization of the RDS glycan in cones versus rods.	Polysaccharides	186-192	peripherin 2	Mus musculus	61-64
26420485-11	2015	These data suggest that glycosylation of RDS is required for RDS function or stability in cones, a difference that may be due to extracellular versus intradiscal localization of the RDS glycan in cones versus rods.	Polysaccharides	186-192	peripherin 2	Mus musculus	61-64
26556271-4	2015	Experiments in which mucin glycans were presented simultaneously with other carbohydrates show that degradation of these host carbohydrates is consistently repressed in the presence of alternative substrates, even by B. thetaiotaomicron previously acclimated to growth in pure mucin glycans.	Polysaccharides	27-34	LOC100508689	Homo sapiens	21-26
26556271-4	2015	Experiments in which mucin glycans were presented simultaneously with other carbohydrates show that degradation of these host carbohydrates is consistently repressed in the presence of alternative substrates, even by B. thetaiotaomicron previously acclimated to growth in pure mucin glycans.	Polysaccharides	283-290	LOC100508689	Homo sapiens	21-26
26556271-5	2015	Experiments with media containing systematically varied carbohydrate cues and genetic mutants reveal that transcriptional repression of genes involved in mucin glycan metabolism is imposed by simple sugars and, in one example that was tested, is mediated through a small intergenic region in a transcript-autonomous fashion.	Polysaccharides	160-166	LOC100508689	Homo sapiens	154-159
26556271-6	2015	Repression of mucin glycan-responsive gene clusters in two other human gut bacteria, Bacteroides massiliensis and Bacteroides fragilis, exhibited variable and sometimes reciprocal responses compared to those of B. thetaiotaomicron, revealing that these symbionts vary in their preference for mucin glycans and that these differences occur at the level of controlling individual gene clusters.	Polysaccharides	20-26	LOC100508689	Homo sapiens	14-19
26556271-6	2015	Repression of mucin glycan-responsive gene clusters in two other human gut bacteria, Bacteroides massiliensis and Bacteroides fragilis, exhibited variable and sometimes reciprocal responses compared to those of B. thetaiotaomicron, revealing that these symbionts vary in their preference for mucin glycans and that these differences occur at the level of controlling individual gene clusters.	Polysaccharides	20-26	LOC100508689	Homo sapiens	292-297
26556271-6	2015	Repression of mucin glycan-responsive gene clusters in two other human gut bacteria, Bacteroides massiliensis and Bacteroides fragilis, exhibited variable and sometimes reciprocal responses compared to those of B. thetaiotaomicron, revealing that these symbionts vary in their preference for mucin glycans and that these differences occur at the level of controlling individual gene clusters.	Polysaccharides	298-305	LOC100508689	Homo sapiens	14-19
26342043-11	2015	CONCLUSIONS: Blood type A is independently associated with AKI risk in critically ill patients with trauma or severe sepsis of European descent, suggesting a role for ABO glycans in AKI susceptibility.	Polysaccharides	171-178	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	167-170
26542212-9	2015	The neuritogenic activity in PC-12 cells stimulated by hot aqueous and ethanolic extracts, and crude polysaccharides of L. rhinocerotis sclerotium mimicking NGF activity via the MEK/ERK1/2 signaling pathway is reported for the first time.	Polysaccharides	101-116	mitogen activated protein kinase 3	Rattus norvegicus	182-188
26256325-1	2015	Three novel acidic polysaccharides termed PRM1, PRM3 and PRM5 were purified from Rhynchosia minima root using DEAE-52 cellulose and sephadex G-150 column chromatography.	Polysaccharides	19-34	protamine 1	Homo sapiens	42-46
26256355-1	2015	In this study, a water-soluble polysaccharide (CSP) was successfully purified from Chaenomeles speciosa by DEAE-Sepharose and Sephadex G-100 column chromatography.	Polysaccharides	31-45	DnaJ heat shock protein family (Hsp40) member C5	Mus musculus	47-50
26527274-2	2015	Previous recombinant protein production of uPARAP in Pichia pastoris generated protein with highly heterogeneous glycans that was prone to proteolytic degradation, resulting in highly twinned crystals.	Polysaccharides	113-120	mannose receptor C type 2	Homo sapiens	43-49
27551476-4	2015	Modified citrus pectin (MCP) is a water-soluble citrus-fruit-derived polysaccharide fiber that specifically inhibits Gal-3.	Polysaccharides	69-83	lectin, galactose binding, soluble 3	Mus musculus	117-122
26154505-3	2015	Sialylation increased on both EPO and CHO cellular proteins as observed by SNA lectin analysis, and HPLC profiling revealed that the sialic acid content of total glycans on EPO increased by 26%.	Polysaccharides	162-169	erythropoietin	Cricetulus griseus	173-176
26086186-3	2015	Neutralizing antibodies directed to a V3-base- and glycan-dependent epitope on gp120 and to the apex of the Env trimer, as well as nonneutralizing antibodies to the epitope cluster I on the gp41-ectodomain, aggregated virions, but in markedly narrow concentration ranges.	Polysaccharides	51-57	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	79-84
26086186-4	2015	In contrast, the neutralizing antibody 2G12, which is specific for a composite glycan-dependent epitope on gp120 and functionally monovalent because of its unusual domain-swap structure, was nonaggregating.	Polysaccharides	79-85	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	107-112
26448449-8	2015	This study provides a parallel method for processing glycan content for haptoglobin and evaluating detailed changes in glycan structures for a potentially large cohort of clinical serum samples.	Polysaccharides	53-59	haptoglobin	Homo sapiens	72-83
26234580-4	2015	Further study demonstrated that the heat stress resistance effect of polysaccharides on C. elegans might be attributed to the elevation of antioxidant enzyme activities (both superoxide dismutase (SOD) and catalase (CAT)) and the reduction lipid peroxidation of malondialdehyde (MDA) level.	Polysaccharides	69-84	Catalase	Caenorhabditis elegans	206-221
26512079-4	2016	However, it is not clear if the role of the N7 glycan is conserved among diverse HIV-1 isolates and if other glycans in the conserved regions of HIV-1 Env display similar functions.	Polysaccharides	109-116	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	151-154
26318666-1	2015	A water-soluble polysaccharide (MCP) was isolated from the fruits of Momordica charantia L., and the hypoglycemic effects of MCP were investigated in both normal healthy and alloxan-induced diabetic mice.	Polysaccharides	16-30	CD46 antigen, complement regulatory protein	Mus musculus	32-35
26321425-0	2015	MDG-1, an Ophiopogon polysaccharide, regulate gut microbiota in high-fat diet-induced obese C57BL/6 mice.	Polysaccharides	21-35	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	0-5
26323321-0	2015	Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1alpha/PPARalpha-FGF21 signaling pathway in male Sprague Dawley rats undergoing catch-up growth.	Polysaccharides	11-26	sirtuin 1	Rattus norvegicus	79-84
26323321-0	2015	Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1alpha/PPARalpha-FGF21 signaling pathway in male Sprague Dawley rats undergoing catch-up growth.	Polysaccharides	11-26	PPARG coactivator 1 alpha	Rattus norvegicus	85-95
26323321-0	2015	Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1alpha/PPARalpha-FGF21 signaling pathway in male Sprague Dawley rats undergoing catch-up growth.	Polysaccharides	11-26	peroxisome proliferator activated receptor alpha	Rattus norvegicus	96-105
26323321-0	2015	Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1alpha/PPARalpha-FGF21 signaling pathway in male Sprague Dawley rats undergoing catch-up growth.	Polysaccharides	11-26	fibroblast growth factor 21	Rattus norvegicus	106-111
26137907-1	2015	OBJECTIVES: It is widely accepted that sialyl Lewis X (sLeX) and sialyl Lewis A (sLeA, also known as CA 19-9) glycans expressed on cancer cells function in E-selectin-mediated metastasis.	Polysaccharides	110-117	selectin E	Homo sapiens	156-166
26137907-12	2015	CONCLUSIONS: Our findings indicate that 6-sulfo sLeX glycans likely play 2 roles in bladder urothelial carcinoma progression: one in lymphocyte recruitment to enhance antitumor immune responses, and the other in E-selectin-mediated tumor cell adhesion to vascular endothelial cells, which is potentially associated with metastasis.	Polysaccharides	53-60	selectin E	Homo sapiens	212-222
26424181-0	2015	Extracellular polysaccharide from Bordetella species reduces high glucose-induced macrophage apoptosis via regulating interaction between caveolin-1 and TLR4.	Polysaccharides	14-28	caveolin 1	Homo sapiens	138-148
26424181-0	2015	Extracellular polysaccharide from Bordetella species reduces high glucose-induced macrophage apoptosis via regulating interaction between caveolin-1 and TLR4.	Polysaccharides	14-28	toll like receptor 4	Homo sapiens	153-157
26512888-5	2015	Using a metabolically incorporated photocrosslinking sugar, we identified one CTB-binding glycoprotein and demonstrated that the glycan portion of the molecule, not the protein, provides the CTB interaction motif.	Polysaccharides	129-135	phosphate cytidylyltransferase 1B, choline	Homo sapiens	191-194
26306769-6	2015	Antibody induced after xenotransplantation in non-human primates is directed to an array of pig endothelial cells proteins and to a glycan produced by the pig B4GALNT2 gene.	Polysaccharides	132-138	beta-1,4 N-acetylgalactosaminyltransferase 2	Sus scrofa	159-167
26543535-10	2015	CONCLUSIONS: Although natural substrates of glycosidase are polysaccharides, in the present study we successfully isolated novel peptide modulators of alpha-glucosidase.	Polysaccharides	60-75	sucrase-isomaltase	Homo sapiens	151-168
26516768-0	2015	A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.	Polysaccharides	6-12	CD4 molecule	Homo sapiens	23-26
26516768-7	2015	Although this group of CD4bs glycan-dependent antibodies can be broadly and potently neutralizing in vitro, their in vivo activity has not been tested to date.	Polysaccharides	29-35	CD4 molecule	Homo sapiens	23-26
26512079-10	2016	However, the role of specific glycans in the conserved regions of HIV-1 Env in modulating epitope recognition by broadly neutralizing antibodies has not been well defined.	Polysaccharides	30-37	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	72-75
26512079-11	2016	We show here that a single N-linked glycan plays a unique and conserved role among conserved glycans on HIV-1 gp120 in modulating the exposure or the stability of the receptor and coreceptor binding site without affecting the integrity of the Env in mediating viral infection or the ability of the mutant gp120 to bind to CD4.	Polysaccharides	93-100	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	110-115
26512079-11	2016	We show here that a single N-linked glycan plays a unique and conserved role among conserved glycans on HIV-1 gp120 in modulating the exposure or the stability of the receptor and coreceptor binding site without affecting the integrity of the Env in mediating viral infection or the ability of the mutant gp120 to bind to CD4.	Polysaccharides	93-100	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	305-310
26512709-6	2015	Despite the presence of the sfGFP, the Env protein largely retained its morphology, antigenicity, glycan composition, and thermostability.	Polysaccharides	98-104	endogenous retrovirus group K member 20	Homo sapiens	39-42
26355155-4	2015	In addition, eight glycan-dependent bNAbs targeting the V1V2 apex (PG9, PG16, and PGT145), the V3 loop (2G12, PGT121, and PGT128), and the gp120-gp41 interface of Env (PGT151 and 35O22) were tested.	Polysaccharides	19-25	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	139-144
26492255-0	2015	Salt Effect on the Antioxidant Activity of Red Microalgal Sulfated Polysaccharides in Soy-Bean Formula.	Polysaccharides	67-82	brain expressed associated with NEDD4 1	Homo sapiens	90-94
26338967-6	2015	To test the hypothesis, therefore, we developed a new glycan microarray-based method for determining ABO blood type.	Polysaccharides	54-60	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	101-104
26448160-12	2015	In the in vitro antimicrobial assay, the lethal dose (LD) 50 of CCL20 for B. abortus (&gt;50 mug/ml) was markedly higher than that against E. coli (1.5 mug/ml) or a B. abortus mutant lacking the O polysaccharide in its LPS (8.7 ug/ml).	Polysaccharides	197-211	C-C motif chemokine ligand 20	Homo sapiens	64-69
26401918-4	2015	In light of this, we have developed a synthetic platform to prepare G-CSF aglycone with the goal of enabling access to native and designed glycoforms with site-selectivity and glycan homogeneity.	Polysaccharides	176-182	colony stimulating factor 3	Homo sapiens	68-73
26355155-4	2015	In addition, eight glycan-dependent bNAbs targeting the V1V2 apex (PG9, PG16, and PGT145), the V3 loop (2G12, PGT121, and PGT128), and the gp120-gp41 interface of Env (PGT151 and 35O22) were tested.	Polysaccharides	19-25	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	163-166
26076605-2	2015	The aim of this study was to examine the effect of extracellular polysaccharide (PEP) from Antarctic bacterium Pseudoaltermonas sp.	Polysaccharides	65-79	prolyl endopeptidase	Mus musculus	81-84
26457433-7	2015	Comparisons with other Env trimer and gp120 structures support an induced conformation for glycan N262, suggesting that the glycan shield is allosterically modified upon PGT128 binding.	Polysaccharides	91-97	endogenous retrovirus group K member 20	Homo sapiens	23-26
26401844-3	2015	We have identified and quantified novel hybrid high-mannosylated MAN1B1-CDG-specific IgG glycans and found an increase of sialyl Lewis x (sLex) glycans on serum proteins of all patients.	Polysaccharides	89-96	mannosidase alpha class 1B member 1	Homo sapiens	65-71
26457433-7	2015	Comparisons with other Env trimer and gp120 structures support an induced conformation for glycan N262, suggesting that the glycan shield is allosterically modified upon PGT128 binding.	Polysaccharides	91-97	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	38-43
26798488-6	2015	These antibodies have unique characteristics which include high levels of somatic mutations and unusually long variable loops that penetrate through the glycan shield of HIV-1 Env to contact the protein surface.	Polysaccharides	153-159	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	176-179
26457433-7	2015	Comparisons with other Env trimer and gp120 structures support an induced conformation for glycan N262, suggesting that the glycan shield is allosterically modified upon PGT128 binding.	Polysaccharides	124-130	endogenous retrovirus group K member 20	Homo sapiens	23-26
26457433-7	2015	Comparisons with other Env trimer and gp120 structures support an induced conformation for glycan N262, suggesting that the glycan shield is allosterically modified upon PGT128 binding.	Polysaccharides	124-130	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	38-43
26197448-9	2015	CONCLUSIONS: The prevalence of the CD-associated anti-glycan antibodies ACCA and AMCA is significantly increased in UC-pouch patients, suggesting that pouch surgery may trigger differential immune responses to glycans.	Polysaccharides	54-60	G protein-coupled receptor 3	Homo sapiens	72-76
26483702-9	2015	These genes include the glycosyltransferase genes Mgat4a, the sialylation enzymes St3gal1 and St3gal4 and glycan binding protein galectin-3, -5, -8, and -9.	Polysaccharides	106-112	galectin 3	Rattus norvegicus	129-155
26026694-2	2015	The underlying pathogenesis of this autoimmune disease comprises the formation of immune complexes, including glycan-specific IgA1 or IgG antibodies and an aberrant glycosylation of IgA1.	Polysaccharides	110-116	immunoglobulin heavy constant alpha 1	Homo sapiens	126-130
26605009-11	2015	Additionally, polysaccharide extracted induced intrinsic apoptosis via up-regulation of caspase-3, caspase-9 and Bax along with down-regulation of Bcl-2 in HeLa cells.	Polysaccharides	14-28	caspase 3	Homo sapiens	88-97
26605009-11	2015	Additionally, polysaccharide extracted induced intrinsic apoptosis via up-regulation of caspase-3, caspase-9 and Bax along with down-regulation of Bcl-2 in HeLa cells.	Polysaccharides	14-28	caspase 9	Homo sapiens	99-108
26605009-11	2015	Additionally, polysaccharide extracted induced intrinsic apoptosis via up-regulation of caspase-3, caspase-9 and Bax along with down-regulation of Bcl-2 in HeLa cells.	Polysaccharides	14-28	BCL2 associated X, apoptosis regulator	Homo sapiens	113-116
26605009-11	2015	Additionally, polysaccharide extracted induced intrinsic apoptosis via up-regulation of caspase-3, caspase-9 and Bax along with down-regulation of Bcl-2 in HeLa cells.	Polysaccharides	14-28	BCL2 apoptosis regulator	Homo sapiens	147-152
26418728-3	2015	Simultaneous recognition of both glycan and the aglycon moieties enhances the affinity and specificity of lectins such as CLEC-2 and PILRalpha.	Polysaccharides	33-39	C-type lectin domain family 1 member B	Homo sapiens	122-128
26418728-3	2015	Simultaneous recognition of both glycan and the aglycon moieties enhances the affinity and specificity of lectins such as CLEC-2 and PILRalpha.	Polysaccharides	33-39	paired immunoglobin like type 2 receptor alpha	Homo sapiens	133-142
26136479-4	2015	Exposure of sperm to Gal-1 resulted in glycan-dependent modulation of the acrosome reaction (AR), a key event in the fertilization process.	Polysaccharides	39-45	galectin 1	Homo sapiens	21-26
26085184-3	2015	In this study, we found that a protein disulfide isomerase homolog TigA can bind with A. oryzae CNX (AoCNX), which was revealed to specifically recognize monoglucosylated glycans, similarly to CNX derived from other species, and accelerate the folding of G1M9GN2-ribonuclease (RNase) in vitro.	Polysaccharides	171-178	calnexin	Homo sapiens	96-99
26085184-3	2015	In this study, we found that a protein disulfide isomerase homolog TigA can bind with A. oryzae CNX (AoCNX), which was revealed to specifically recognize monoglucosylated glycans, similarly to CNX derived from other species, and accelerate the folding of G1M9GN2-ribonuclease (RNase) in vitro.	Polysaccharides	171-178	calnexin	Homo sapiens	103-106
26303218-0	2015	MyD88-dependent pro-inflammatory activity in Vi polysaccharide vaccine against typhoid promotes Ab switching to IgG.	Polysaccharides	48-62	myeloid differentiation primary response gene 88	Mus musculus	0-5
26197448-9	2015	CONCLUSIONS: The prevalence of the CD-associated anti-glycan antibodies ACCA and AMCA is significantly increased in UC-pouch patients, suggesting that pouch surgery may trigger differential immune responses to glycans.	Polysaccharides	210-217	G protein-coupled receptor 3	Homo sapiens	72-76
26246566-9	2015	These data inform immunogen design and suggest that it is useful to obscure nonneutralizing epitopes presented on the base of soluble Env trimers and that the glycan shield of well-formed HIV Env trimers is virtually impenetrable for murine B cell receptors (BCRs).	Polysaccharides	159-165	melanoma antigen	Mus musculus	192-195
26402790-5	2015	These simulations suggest that deviations in FSH/FSHR binding profile as a function of glycosylation state are modest when FSH is adorned with only small glycans, such as single N-acetylglucosamine residues.	Polysaccharides	154-161	follicle stimulating hormone receptor	Homo sapiens	49-53
27182458-5	2015	To accomplish both, stabilization and targeting simultaneously, the apoptosis-inducing protein cytochrome c (Cyt c) was modified with the polysaccharide hyaluronic acid (HA) because its corresponding receptor CD44 is overexpressed in many cancers.	Polysaccharides	138-152	cytochrome c, somatic	Homo sapiens	95-107
27182458-5	2015	To accomplish both, stabilization and targeting simultaneously, the apoptosis-inducing protein cytochrome c (Cyt c) was modified with the polysaccharide hyaluronic acid (HA) because its corresponding receptor CD44 is overexpressed in many cancers.	Polysaccharides	138-152	cytochrome c, somatic	Homo sapiens	109-114
27182458-5	2015	To accomplish both, stabilization and targeting simultaneously, the apoptosis-inducing protein cytochrome c (Cyt c) was modified with the polysaccharide hyaluronic acid (HA) because its corresponding receptor CD44 is overexpressed in many cancers.	Polysaccharides	138-152	CD44 molecule (Indian blood group)	Homo sapiens	209-213
26403574-2	2015	Lon protease of Escherichia coli is implicated in the turnover of RcsA (positive regulator of genes involved in capsular polysaccharide synthesis) and SulA (cell division inhibitor induced upon DNA damage).	Polysaccharides	121-135	putative ATP-dependent Lon protease	Escherichia coli	0-3
26403574-3	2015	Failure to degrade RcsA and SulA makes lon mutant cells to overproduce capsular polysaccharides and to become sensitive to DNA damaging agents.	Polysaccharides	80-95	putative ATP-dependent Lon protease	Escherichia coli	39-42
26177744-6	2015	The new method is exemplified by the analysis of the impact of inactivating mutations of the TGF-ss-receptor type II (TGFBR2) on sialic acid incorporation into protein-linked glycans of the colon cancer cell line HCT116.	Polysaccharides	175-182	transforming growth factor beta receptor 2	Homo sapiens	118-124
26323486-1	2015	The aim of the present study was to examine the role of Ganoderma atrum polysaccharide (PSG-1) in reactive oxygen species (ROS) generation and mitochondrial function in hyperglycemia-induced angiopathy.	Polysaccharides	72-86	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	88-93
26172302-8	2015	Administration of specific BRAF(V600E) inhibitors resulted in decreased expression of MGL-binding glycans.	Polysaccharides	98-105	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	27-31
26277072-1	2015	The glycan shield on the human immunodeficiency virus 1 (HIV-1) envelope (Env) glycoprotein has drawn attention as a target for HIV-1 vaccine design given that an increasing number of potent and broadly neutralizing antibodies (bNAbs) recognize epitopes entirely or partially comprised of high mannose type N-linked glycans.	Polysaccharides	4-10	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	74-77
26172302-8	2015	Administration of specific BRAF(V600E) inhibitors resulted in decreased expression of MGL-binding glycans.	Polysaccharides	98-105	C-type lectin domain containing 10A	Homo sapiens	86-89
26172302-10	2015	We conclude that the BRAF(V600E) mutation induces MGL ligand expression, thereby providing a direct link between oncogenic transformation and aberrant expression of immunosuppressive glycans.	Polysaccharides	183-190	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	21-26
26172302-10	2015	We conclude that the BRAF(V600E) mutation induces MGL ligand expression, thereby providing a direct link between oncogenic transformation and aberrant expression of immunosuppressive glycans.	Polysaccharides	183-190	C-type lectin domain containing 10A	Homo sapiens	50-53
26393572-0	2015	Protective Effects of MDG-1, a Polysaccharide from Ophiopogon japonicus on Diabetic Nephropathy in Diabetic KKAy Mice.	Polysaccharides	31-45	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	22-27
26270612-3	2015	Cell binding by using glycosylation mutants reveals binding of the N-terminal domain of chicken galectin-8 (CG-8N) to alpha-2,3-sialylated and galactose-terminated glycan chains.	Polysaccharides	164-170	galectin 8	Gallus gallus	96-106
26317410-2	2015	In the present study, a water-soluble polysaccharide fraction (SCP-1) was prepared from S. constricta by enzyme-assisted extraction and purification of chromatography with DEAE-52 cellulose anion-exchange column and Sephadex G-100 size exclusion column.	Polysaccharides	38-52	stem cell proliferation 1	Mus musculus	63-68
26393572-2	2015	Recent research confirmed that MDG-1, a polysaccharide from O. japonicas, activates the PI3K/Akt signaling pathway and improves insulin sensitivity in a diabetic KKAy mouse model, but little is known about its effects on diabetic nephropathy.	Polysaccharides	40-54	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	31-36
26768625-13	2015	BGF and other related glycan analogues should further be explored for their ability to down modulate endothelial activation in TNF-alpha driven pathophysiologic conditions in autoimmune disease and cancer indications.	Polysaccharides	22-28	tumor necrosis factor	Homo sapiens	127-136
26190353-3	2015	This study aimed to determine the role and mechanism of action of polysaccharides isolated from HC (HCP) in lipopolysaccharide (LPS)-induced ALI in the mice.	Polysaccharides	66-81	hypochondrodysplasia	Mus musculus	100-103
26299951-0	2015	WSS25, a sulfated polysaccharide, inhibits RANKL-induced mouse osteoclast formation by blocking SMAD/ID1 signaling.	Polysaccharides	18-32	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	43-48
26231686-10	2015	Unique glycan data was also provided for each Fc subclass, which is particularly important for IgG3; glycans from this subclass have only previously been reported together with IgG2 or IgG4.	Polysaccharides	7-13	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	95-99
26299951-1	2015	AIM: WSS25 is a sulfated polysaccharide extracted from the rhizome of Gastrodia elata BI, which has been found to bind to bone morphogenetic protein 2 (BMP-2) in hepatocellular cancer cells.	Polysaccharides	25-39	bone morphogenetic protein 2	Mus musculus	152-157
26187193-1	2015	Polysaccharides differing in structure and chemical nature were screened for their ability to bind non-covalently with polyphenol oxidase (PPO) from potato (as a model) and their effect on enzyme activity.	Polysaccharides	0-15	catechol oxidase B, chloroplastic	Solanum tuberosum	119-137
26058806-3	2015	In this study MAGEA10 was scarcely expressed in cancer patients, but enhanced by viili polysaccharides, which indicates a possibility of increasing epitopes presentation.	Polysaccharides	87-102	MAGE family member A10	Homo sapiens	14-21
26187193-1	2015	Polysaccharides differing in structure and chemical nature were screened for their ability to bind non-covalently with polyphenol oxidase (PPO) from potato (as a model) and their effect on enzyme activity.	Polysaccharides	0-15	catechol oxidase B, chloroplastic	Solanum tuberosum	139-142
26187193-2	2015	All the polysaccharides selected inhibited the PPO but beta-cyclodextrin showed maximum inhibition under optimum conditions.	Polysaccharides	8-23	catechol oxidase B, chloroplastic	Solanum tuberosum	47-50
26930984-6	2015	RESULT: AA decoction, timosaponin and polysaccharides significantly reduced the immune organ index and ear edema degree (P &lt; 0.05), protein expression of IFN-gamma was inhibited by AA timosaponin fraction and polysaccharides fraction.	Polysaccharides	38-53	interferon gamma	Mus musculus	157-166
26085151-3	2015	Characterizing the glycan structures present on native HIV-1 Env is thus a critical goal for the design of Env immunogens.	Polysaccharides	19-25	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	61-64
26085151-3	2015	Characterizing the glycan structures present on native HIV-1 Env is thus a critical goal for the design of Env immunogens.	Polysaccharides	19-25	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	107-110
26085151-4	2015	In this study, we used a complementary, multistep approach involving ion mobility mass spectrometry and high-performance liquid chromatography to comprehensively characterize the glycan structures present on HIV-1 gp120 produced in peripheral blood mononuclear cells (PBMCs).	Polysaccharides	179-185	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	214-219
26085151-12	2015	It is therefore important to characterize the glycan structures present on native, virion-associated gp120 and gp41 for development of vaccines that accurately mimic native-Env glycosylation.	Polysaccharides	46-52	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	101-106
26085151-12	2015	It is therefore important to characterize the glycan structures present on native, virion-associated gp120 and gp41 for development of vaccines that accurately mimic native-Env glycosylation.	Polysaccharides	46-52	endogenous retrovirus group K member 20	Homo sapiens	173-176
26085151-13	2015	In this study, we used a number of analytical techniques to precisely study the structures of both the oligomannose and complex-type glycans present on native Env to provide a reference for determining the ability of potential HIV immunogens to accurately replicate the glycosylation pattern on these native structures.	Polysaccharides	133-140	endogenous retrovirus group K member 20	Homo sapiens	159-162
25874498-0	2015	A Aconitum coreanum polysaccharide fraction induces apoptosis of hepatocellular carcinoma (HCC) cells via pituitary tumor transforming gene 1 (PTTG1)-mediated suppression of the P13K/Akt and activation of p38 MAPK signaling pathway and displays antitumor activity in vivo.	Polysaccharides	20-34	pituitary tumor-transforming gene 1	Mus musculus	106-141
25874498-0	2015	A Aconitum coreanum polysaccharide fraction induces apoptosis of hepatocellular carcinoma (HCC) cells via pituitary tumor transforming gene 1 (PTTG1)-mediated suppression of the P13K/Akt and activation of p38 MAPK signaling pathway and displays antitumor activity in vivo.	Polysaccharides	20-34	pituitary tumor-transforming gene 1	Mus musculus	143-148
25874498-0	2015	A Aconitum coreanum polysaccharide fraction induces apoptosis of hepatocellular carcinoma (HCC) cells via pituitary tumor transforming gene 1 (PTTG1)-mediated suppression of the P13K/Akt and activation of p38 MAPK signaling pathway and displays antitumor activity in vivo.	Polysaccharides	20-34	thymoma viral proto-oncogene 1	Mus musculus	183-186
25874498-0	2015	A Aconitum coreanum polysaccharide fraction induces apoptosis of hepatocellular carcinoma (HCC) cells via pituitary tumor transforming gene 1 (PTTG1)-mediated suppression of the P13K/Akt and activation of p38 MAPK signaling pathway and displays antitumor activity in vivo.	Polysaccharides	20-34	mitogen-activated protein kinase 14	Mus musculus	205-208
25885805-3	2015	Here we show using a human skin explant model that the in situ targeting of antigens to DC-SIGN using glycan-modified liposomes enhances the antigen-presenting capacity of CD14(+) dDCs.	Polysaccharides	102-108	CD209 molecule	Homo sapiens	88-95
25885805-3	2015	Here we show using a human skin explant model that the in situ targeting of antigens to DC-SIGN using glycan-modified liposomes enhances the antigen-presenting capacity of CD14(+) dDCs.	Polysaccharides	102-108	CD14 molecule	Homo sapiens	172-176
25885805-4	2015	Intradermal vaccination of liposomes modified with the DC-SIGN-targeting glycan Lewis(X), containing melanoma antigens (MART-1 or Gp100), accumulated in CD14(+) dDCs and resulted in enhanced Gp100- or MART-1-specific CD8(+) T-cell responses.	Polysaccharides	73-79	CD209 molecule	Homo sapiens	55-62
25885805-4	2015	Intradermal vaccination of liposomes modified with the DC-SIGN-targeting glycan Lewis(X), containing melanoma antigens (MART-1 or Gp100), accumulated in CD14(+) dDCs and resulted in enhanced Gp100- or MART-1-specific CD8(+) T-cell responses.	Polysaccharides	73-79	melan-A	Homo sapiens	120-126
25885805-4	2015	Intradermal vaccination of liposomes modified with the DC-SIGN-targeting glycan Lewis(X), containing melanoma antigens (MART-1 or Gp100), accumulated in CD14(+) dDCs and resulted in enhanced Gp100- or MART-1-specific CD8(+) T-cell responses.	Polysaccharides	73-79	premelanosome protein	Homo sapiens	130-135
25885805-4	2015	Intradermal vaccination of liposomes modified with the DC-SIGN-targeting glycan Lewis(X), containing melanoma antigens (MART-1 or Gp100), accumulated in CD14(+) dDCs and resulted in enhanced Gp100- or MART-1-specific CD8(+) T-cell responses.	Polysaccharides	73-79	CD14 molecule	Homo sapiens	153-157
25885805-4	2015	Intradermal vaccination of liposomes modified with the DC-SIGN-targeting glycan Lewis(X), containing melanoma antigens (MART-1 or Gp100), accumulated in CD14(+) dDCs and resulted in enhanced Gp100- or MART-1-specific CD8(+) T-cell responses.	Polysaccharides	73-79	premelanosome protein	Homo sapiens	191-196
25885805-4	2015	Intradermal vaccination of liposomes modified with the DC-SIGN-targeting glycan Lewis(X), containing melanoma antigens (MART-1 or Gp100), accumulated in CD14(+) dDCs and resulted in enhanced Gp100- or MART-1-specific CD8(+) T-cell responses.	Polysaccharides	73-79	melan-A	Homo sapiens	201-207
25885805-4	2015	Intradermal vaccination of liposomes modified with the DC-SIGN-targeting glycan Lewis(X), containing melanoma antigens (MART-1 or Gp100), accumulated in CD14(+) dDCs and resulted in enhanced Gp100- or MART-1-specific CD8(+) T-cell responses.	Polysaccharides	73-79	CD8a molecule	Homo sapiens	217-220
26013532-3	2015	The mutant was identified as an allele of UDP-glucose epimerase 4 (UGE4)/root hair defective 1/root epidermal bulgar 1, which was previously described as a mutant with swollen root epidermal cells and has an altered sugar composition in cell wall polysaccharides.	Polysaccharides	247-262	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	42-65
26013532-3	2015	The mutant was identified as an allele of UDP-glucose epimerase 4 (UGE4)/root hair defective 1/root epidermal bulgar 1, which was previously described as a mutant with swollen root epidermal cells and has an altered sugar composition in cell wall polysaccharides.	Polysaccharides	247-262	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	67-71
25307474-8	2015	In addition, pectinase-driven hydrolysis in polysaccharides significantly increased TPS-induced Interleukin 6 (IL-6) production in macrophages.	Polysaccharides	44-59	interleukin 6	Homo sapiens	96-109
25307474-8	2015	In addition, pectinase-driven hydrolysis in polysaccharides significantly increased TPS-induced Interleukin 6 (IL-6) production in macrophages.	Polysaccharides	44-59	interleukin 6	Homo sapiens	111-115
26930984-6	2015	RESULT: AA decoction, timosaponin and polysaccharides significantly reduced the immune organ index and ear edema degree (P &lt; 0.05), protein expression of IFN-gamma was inhibited by AA timosaponin fraction and polysaccharides fraction.	Polysaccharides	212-227	interferon gamma	Mus musculus	157-166
26170455-0	2015	Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.	Polysaccharides	68-74	C-type lectin domain family 18 member A	Homo sapiens	6-12
26152729-4	2015	We found that the vitamin fully prevented increased permeability to the polysaccharide inulin by thrombin in a dose-dependent manner, and it took effect both before and after subjection to thrombin.	Polysaccharides	72-86	coagulation factor II, thrombin	Homo sapiens	97-105
26170455-8	2015	Moreover, CLEC18 bind polysaccharide in Ca(2+)-independent manner, and amino acid residues Ser/Arg(339) and Asp/Asn(421) in CTLD domain contribute to their differential binding abilities to polysaccharides isolated from Ganoderma lucidum (GLPS-F3).	Polysaccharides	22-36	C-type lectin domain family 18 member A	Homo sapiens	10-16
26170455-8	2015	Moreover, CLEC18 bind polysaccharide in Ca(2+)-independent manner, and amino acid residues Ser/Arg(339) and Asp/Asn(421) in CTLD domain contribute to their differential binding abilities to polysaccharides isolated from Ganoderma lucidum (GLPS-F3).	Polysaccharides	190-205	C-type lectin domain family 18 member A	Homo sapiens	10-16
26232512-0	2015	Hypoxia inducible factor 1alpha down regulates cell surface expression of alpha1,2-fucosylated glycans in human pancreatic adenocarcinoma cells.	Polysaccharides	95-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-31
26302170-5	2015	Subsequently, we solved high-resolution X-ray structures of the major capsid protein VP1 of TSPyV in complex with three different glycans, the branched GM1 glycan, and the linear trisaccharides alpha2,3- and alpha2,6-sialyllactose.	Polysaccharides	130-137	structural protein VP1	Trichodysplasia spinulosa-associated polyomavirus	85-88
26302170-6	2015	The terminal sialic acid of all three glycans is engaged in a unique binding site on TSPyV VP1, which is positioned about 18 A from established sialic acid binding sites of other polyomaviruses.	Polysaccharides	38-45	structural protein VP1	Trichodysplasia spinulosa-associated polyomavirus	91-94
26302170-7	2015	Structure-based mutagenesis of sialic acid-binding residues leads to reduction in cell attachment and pseudovirus infection, demonstrating the physiological relevance of the TSPyV VP1-glycan interaction.	Polysaccharides	184-190	structural protein VP1	Trichodysplasia spinulosa-associated polyomavirus	180-183
26232512-3	2015	Down regulation of HIF-1alpha expression resulted in elevated FUT1 and FUT2 transcript levels and an increased expression of alpha1,2-fucosylated glycan structures on the surface of these cells.	Polysaccharides	146-152	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-29
26193334-0	2015	Enhancement of the Immunostimulatory Activity of a TLR7 Ligand by Conjugation to Polysaccharides.	Polysaccharides	81-96	toll-like receptor 7	Mus musculus	51-55
26193334-4	2015	Here, we conjugated a versatile low molecular weight TLR7 ligand to various polysaccharides in order to improve its water solubility, enhance its potency, and maintain low toxicity.	Polysaccharides	76-91	toll-like receptor 7	Mus musculus	53-57
26232512-4	2015	In conclusion, our data are the first to identify HIF-1alpha as a suppressor of FUT1/2 expression, thereby regulating alpha1,2-fucosylation of cell-surface glycans.	Polysaccharides	156-163	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-60
26193334-7	2015	The zeta potential value of the polysaccharides was decreased in inverse proportion to the ratio of conjugated TLR7 ligand.	Polysaccharides	32-47	toll-like receptor 7	Mus musculus	111-115
26193334-9	2015	In vitro studies with murine mononuclear leukocytes showed that the TLR7 agonist conjugated to polysaccharides had 10- to 1000-fold higher potencies than the unconjugated TLR7 ligand.	Polysaccharides	95-110	toll-like receptor 7	Mus musculus	68-72
26232512-4	2015	In conclusion, our data are the first to identify HIF-1alpha as a suppressor of FUT1/2 expression, thereby regulating alpha1,2-fucosylation of cell-surface glycans.	Polysaccharides	156-163	protein O-fucosyltransferase 1	Homo sapiens	80-86
26193334-9	2015	In vitro studies with murine mononuclear leukocytes showed that the TLR7 agonist conjugated to polysaccharides had 10- to 1000-fold higher potencies than the unconjugated TLR7 ligand.	Polysaccharides	95-110	toll-like receptor 7	Mus musculus	171-175
26193334-12	2015	These results indicated that small molecule TLR7 ligands conjugated to polysaccharides have improved immunostimulatory potency and pharmacodynamics.	Polysaccharides	71-86	toll-like receptor 7	Mus musculus	44-48
26291458-9	2015	Of the seven predicted glycan acceptor sites in Drosophila Smo, one is essential.	Polysaccharides	23-29	smoothened	Drosophila melanogaster	59-62
25857669-7	2015	Benchmark tests against the Protein Data Bank (PDB) N-linked glycan library and PDB homologous/non-homologous N-glycoprotein sets indicate that GS-align is a robust computational tool to align glycan structures and quantify their structural similarity.	Polysaccharides	61-67	dehydrogenase/reductase 2	Homo sapiens	28-45
26168351-1	2015	Galectin-3 binding protein (Gal-3BP) is a large hyperglycosylated protein that acts as a ligand for several galectins through glycan-dependent interactions.	Polysaccharides	126-132	galectin 3 binding protein	Homo sapiens	0-26
26168351-1	2015	Galectin-3 binding protein (Gal-3BP) is a large hyperglycosylated protein that acts as a ligand for several galectins through glycan-dependent interactions.	Polysaccharides	126-132	galectin 3 binding protein	Homo sapiens	28-35
26168351-3	2015	However, the galectin interacting with Gal-3BP and its binding specificity has not been identified and structurally elucidated, mainly due to the limitation of mass spectrometry in glycan sequencing.	Polysaccharides	181-187	galectin 3 binding protein	Homo sapiens	39-46
25713410-3	2015	B2R desensitization induced by BK or B2R internalization-inducing glycans cross-desensitized the P2Y2R response to ATP/UTP.	Polysaccharides	66-73	bradykinin receptor B2	Homo sapiens	0-3
25878069-1	2015	The present study demonstrates that fucose-containing sulfated polysaccharides (FCSP) from brown algae interfere with the CXCL12/CXCR4 axis in human Burkitt"s lymphoma cells by binding CXCL12 and thereby blocking both CXCL12-induced CXCR4 receptor activation and downstream effects like migration and secretion of matrix metalloproteinase-9.	Polysaccharides	63-78	C-X-C motif chemokine ligand 12	Homo sapiens	122-128
25878069-1	2015	The present study demonstrates that fucose-containing sulfated polysaccharides (FCSP) from brown algae interfere with the CXCL12/CXCR4 axis in human Burkitt"s lymphoma cells by binding CXCL12 and thereby blocking both CXCL12-induced CXCR4 receptor activation and downstream effects like migration and secretion of matrix metalloproteinase-9.	Polysaccharides	63-78	C-X-C motif chemokine receptor 4	Homo sapiens	129-134
25878069-1	2015	The present study demonstrates that fucose-containing sulfated polysaccharides (FCSP) from brown algae interfere with the CXCL12/CXCR4 axis in human Burkitt"s lymphoma cells by binding CXCL12 and thereby blocking both CXCL12-induced CXCR4 receptor activation and downstream effects like migration and secretion of matrix metalloproteinase-9.	Polysaccharides	63-78	C-X-C motif chemokine ligand 12	Homo sapiens	185-191
25878069-1	2015	The present study demonstrates that fucose-containing sulfated polysaccharides (FCSP) from brown algae interfere with the CXCL12/CXCR4 axis in human Burkitt"s lymphoma cells by binding CXCL12 and thereby blocking both CXCL12-induced CXCR4 receptor activation and downstream effects like migration and secretion of matrix metalloproteinase-9.	Polysaccharides	63-78	C-X-C motif chemokine ligand 12	Homo sapiens	185-191
25878069-1	2015	The present study demonstrates that fucose-containing sulfated polysaccharides (FCSP) from brown algae interfere with the CXCL12/CXCR4 axis in human Burkitt"s lymphoma cells by binding CXCL12 and thereby blocking both CXCL12-induced CXCR4 receptor activation and downstream effects like migration and secretion of matrix metalloproteinase-9.	Polysaccharides	63-78	C-X-C motif chemokine receptor 4	Homo sapiens	233-238
25878069-1	2015	The present study demonstrates that fucose-containing sulfated polysaccharides (FCSP) from brown algae interfere with the CXCL12/CXCR4 axis in human Burkitt"s lymphoma cells by binding CXCL12 and thereby blocking both CXCL12-induced CXCR4 receptor activation and downstream effects like migration and secretion of matrix metalloproteinase-9.	Polysaccharides	63-78	matrix metallopeptidase 9	Homo sapiens	314-340
26114192-0	2015	The hypoglycemic effect of a polysaccharide (GLP) from Gracilaria lemaneiformis and its degradation products in diabetic mice.	Polysaccharides	29-43	euchromatic histone methyltransferase 1	Mus musculus	45-48
26114192-2	2015	In the present study, the hypoglycemic and antioxidant effects of a polysaccharide extracted from Gracilaria lemaneiformis (GLP; Mw, 121.89 kDa) and its chemically degraded products (GLP1 and GLP2: Mw, 57.02 and 14.29 kDa, respectively) were investigated in alloxan-induced diabetic mice.	Polysaccharides	68-82	euchromatic histone methyltransferase 1	Mus musculus	124-127
26114192-2	2015	In the present study, the hypoglycemic and antioxidant effects of a polysaccharide extracted from Gracilaria lemaneiformis (GLP; Mw, 121.89 kDa) and its chemically degraded products (GLP1 and GLP2: Mw, 57.02 and 14.29 kDa, respectively) were investigated in alloxan-induced diabetic mice.	Polysaccharides	68-82	euchromatic histone methyltransferase 1	Mus musculus	183-187
26114192-2	2015	In the present study, the hypoglycemic and antioxidant effects of a polysaccharide extracted from Gracilaria lemaneiformis (GLP; Mw, 121.89 kDa) and its chemically degraded products (GLP1 and GLP2: Mw, 57.02 and 14.29 kDa, respectively) were investigated in alloxan-induced diabetic mice.	Polysaccharides	68-82	glucagon-like peptide 2 receptor	Mus musculus	192-196
25713410-3	2015	B2R desensitization induced by BK or B2R internalization-inducing glycans cross-desensitized the P2Y2R response to ATP/UTP.	Polysaccharides	66-73	bradykinin receptor B2	Homo sapiens	37-40
25713410-3	2015	B2R desensitization induced by BK or B2R internalization-inducing glycans cross-desensitized the P2Y2R response to ATP/UTP.	Polysaccharides	66-73	purinergic receptor P2Y2	Homo sapiens	97-102
26148048-0	2015	Recognition of microbial glycans by human intelectin-1.	Polysaccharides	25-32	intelectin 1	Homo sapiens	42-54
26018173-8	2015	These site-level studies are important for understanding antibody-glycan interactions on native Env trimers.	Polysaccharides	66-72	endogenous retrovirus group K member 20	Homo sapiens	96-99
26192331-3	2015	The ternary complex of ST8SiaIII with a donor sugar analog and a sulfated glycan acceptor identified with a sialyltransferase glycan array provides insight into the residues involved in substrate binding, specificity and sialyl transfer.	Polysaccharides	74-80	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	Homo sapiens	23-32
26192331-3	2015	The ternary complex of ST8SiaIII with a donor sugar analog and a sulfated glycan acceptor identified with a sialyltransferase glycan array provides insight into the residues involved in substrate binding, specificity and sialyl transfer.	Polysaccharides	126-132	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	Homo sapiens	23-32
26129647-8	2015	(1)H-(15)N heteronuclear single-quantum coherence spectroscopy nuclear magnetic resonance data reveal contact at the canonical site mainly by the glycan moiety of the MUC1 glycopeptide.	Polysaccharides	146-152	mucin 1, cell surface associated	Homo sapiens	167-171
26271980-1	2015	OBJECTIVE: To investigate the effects of Astragalus polysaccharide (APS) on the expressions of apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) and thioredoxin (TRX) in MRC-5 human embryo lung fibroblasts induced by hydrogen peroxide (H2O2) and explore the mechanism of APS protecting MRC-5 cells from oxidative damage.	Polysaccharides	52-66	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	146-149
26271980-1	2015	OBJECTIVE: To investigate the effects of Astragalus polysaccharide (APS) on the expressions of apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) and thioredoxin (TRX) in MRC-5 human embryo lung fibroblasts induced by hydrogen peroxide (H2O2) and explore the mechanism of APS protecting MRC-5 cells from oxidative damage.	Polysaccharides	52-66	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	150-155
26271980-1	2015	OBJECTIVE: To investigate the effects of Astragalus polysaccharide (APS) on the expressions of apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) and thioredoxin (TRX) in MRC-5 human embryo lung fibroblasts induced by hydrogen peroxide (H2O2) and explore the mechanism of APS protecting MRC-5 cells from oxidative damage.	Polysaccharides	52-66	thioredoxin	Homo sapiens	161-172
26271980-1	2015	OBJECTIVE: To investigate the effects of Astragalus polysaccharide (APS) on the expressions of apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) and thioredoxin (TRX) in MRC-5 human embryo lung fibroblasts induced by hydrogen peroxide (H2O2) and explore the mechanism of APS protecting MRC-5 cells from oxidative damage.	Polysaccharides	52-66	thioredoxin	Homo sapiens	174-177
25787750-0	2015	A Huaier polysaccharide reduced metastasis of human hepatocellular carcinoma SMMC-7721 cells via modulating AUF-1 signaling pathway.	Polysaccharides	9-23	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	108-113
25787750-1	2015	TP-1 is a polysaccharide from one famous fungus Huaier.	Polysaccharides	10-24	transition protein 1	Homo sapiens	0-4
26405690-4	2015	A screen for RNase A ligands in an array of mammalian cell-surface glycans revealed strong affinity for a hexasaccharide, Globo H, that is a tumor-associated antigen and the basis for a vaccine in clinical trials.	Polysaccharides	67-74	ribonuclease A family member 1, pancreatic	Homo sapiens	13-20
26091901-2	2015	We here isolated the polysaccharides (PAP) from the fruiting bodies of P. abalonus, and evaluated the antiproliferative activity of the polysaccharides in human colorectal carcinoma LoVo cells.	Polysaccharides	21-36	regenerating family member 3 alpha	Homo sapiens	38-41
26091901-2	2015	We here isolated the polysaccharides (PAP) from the fruiting bodies of P. abalonus, and evaluated the antiproliferative activity of the polysaccharides in human colorectal carcinoma LoVo cells.	Polysaccharides	136-151	regenerating family member 3 alpha	Homo sapiens	38-41
26284045-1	2015	Colonization of the squid Euprymna scolopes by Vibrio fischeri requires biofilm formation dependent on the 18-gene symbiosis polysaccharide locus, syp.	Polysaccharides	125-139	synaptophysin	Homo sapiens	147-150
26091356-3	2015	The focused glycan analysis using 43-lectin-immobilized microarray could obtain the glycan profiles of sialylated MUC1 in 5 muL of sera.	Polysaccharides	12-18	mucin 1, cell surface associated	Homo sapiens	114-118
26193330-5	2015	The findings show that the amount of glycans is dramatically reduced upon the co-expression of cytosolic sialidase NEU2 with cytosolic beta-glycosidase GBA3 in human stomach cancer-derived MKN45 cells.	Polysaccharides	37-44	neuraminidase 2	Homo sapiens	115-119
26091356-3	2015	The focused glycan analysis using 43-lectin-immobilized microarray could obtain the glycan profiles of sialylated MUC1 in 5 muL of sera.	Polysaccharides	84-90	mucin 1, cell surface associated	Homo sapiens	114-118
26200113-0	2015	Glycoengineered Monoclonal Antibodies with Homogeneous Glycan (M3, G0, G2, and A2) Using a Chemoenzymatic Approach Have Different Affinities for FcgammaRIIIa and Variable Antibody-Dependent Cellular Cytotoxicity Activities.	Polysaccharides	55-61	Fc gamma receptor IIIa	Homo sapiens	145-157
26193330-5	2015	The findings show that the amount of glycans is dramatically reduced upon the co-expression of cytosolic sialidase NEU2 with cytosolic beta-glycosidase GBA3 in human stomach cancer-derived MKN45 cells.	Polysaccharides	37-44	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	152-156
26055498-2	2015	Glycogen synthase (GS) and glycogen phosphorylase (GP) are the two enzymes that control, respectively, the synthesis and degradation of this polysaccharide and constitute adequate pharmacological targets to modulate cellular glycogen levels, by means of inhibition of their catalytic activity.	Polysaccharides	141-155	glycogen phosphorylase L	Rattus norvegicus	27-49
25857979-6	2015	The results showed that RP1 and RP2 were homogeneously protein-bound polysaccharides with molecular weights of 28.51 and 6.55 kDa, respectively.	Polysaccharides	69-84	RP1 axonemal microtubule associated	Homo sapiens	24-27
25857979-2	2015	After preliminary treatments, two fractions of polysaccharides (RP1 and RP2) were obtained after purification by DEAE-cellulose and Sephadex G-100.	Polysaccharides	47-62	RP1 axonemal microtubule associated	Homo sapiens	64-67
25857979-2	2015	After preliminary treatments, two fractions of polysaccharides (RP1 and RP2) were obtained after purification by DEAE-cellulose and Sephadex G-100.	Polysaccharides	47-62	RP2 activator of ARL3 GTPase	Homo sapiens	72-75
25857979-6	2015	The results showed that RP1 and RP2 were homogeneously protein-bound polysaccharides with molecular weights of 28.51 and 6.55 kDa, respectively.	Polysaccharides	69-84	RP2 activator of ARL3 GTPase	Homo sapiens	32-35
26161135-0	2015	Astragalus polysaccharide promotes the release of mature granulocytes through the L-selectin signaling pathway.	Polysaccharides	11-25	selectin L	Rattus norvegicus	82-92
25995448-0	2015	A Novel Mechanism for Binding of Galactose-terminated Glycans by the C-type Carbohydrate Recognition Domain in Blood Dendritic Cell Antigen 2.	Polysaccharides	54-61	C-type lectin domain family 4 member C	Homo sapiens	111-141
25995448-4	2015	A combination of glycan array analysis and binding competition studies with monosaccharides and natural and synthetic oligosaccharides have been used to define the binding epitope for BDCA-2 as the trisaccharide Galbeta1-3/4GlcNAcbeta1-2Man.	Polysaccharides	17-23	C-type lectin domain family 4 member C	Homo sapiens	184-190
25995448-6	2015	As predicted from these studies, BDCA-2 binds to IgG, which bears galactose-terminated glycans that are not commonly found attached to other serum glycoproteins.	Polysaccharides	87-94	C-type lectin domain family 4 member C	Homo sapiens	33-39
26062005-2	2015	Glucosidase II (GII) plays a critical role by generating monoglucosylated glycans that are recognized by lectin chaperones, calnexin and calreticulin.	Polysaccharides	74-81	calnexin	Homo sapiens	124-132
26062005-2	2015	Glucosidase II (GII) plays a critical role by generating monoglucosylated glycans that are recognized by lectin chaperones, calnexin and calreticulin.	Polysaccharides	74-81	calreticulin	Homo sapiens	137-149
25919894-2	2015	Here we describe detailed analysis of the interaction of human ZG16p with mycobacterial phosphatidylinositol mannosides (PIMs) by glycan microarray and NMR.	Polysaccharides	130-136	zymogen granule protein 16	Homo sapiens	63-68
25919894-3	2015	Pathogen-related glycan microarray analysis identified phosphatidylinositol mono- and di-mannosides (PIM1 and PIM2) as novel ligand candidates of ZG16p.	Polysaccharides	17-23	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	101-105
25919894-3	2015	Pathogen-related glycan microarray analysis identified phosphatidylinositol mono- and di-mannosides (PIM1 and PIM2) as novel ligand candidates of ZG16p.	Polysaccharides	17-23	Pim-2 proto-oncogene, serine/threonine kinase	Homo sapiens	110-114
25919894-3	2015	Pathogen-related glycan microarray analysis identified phosphatidylinositol mono- and di-mannosides (PIM1 and PIM2) as novel ligand candidates of ZG16p.	Polysaccharides	17-23	zymogen granule protein 16	Homo sapiens	146-151
25919894-4	2015	Saturation transfer difference (STD) NMR and transferred NOE experiments with chemically synthesized PIM glycans indicate that PIMs preferentially interact with ZG16p by using the mannose residues.	Polysaccharides	105-112	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	101-104
25919894-4	2015	Saturation transfer difference (STD) NMR and transferred NOE experiments with chemically synthesized PIM glycans indicate that PIMs preferentially interact with ZG16p by using the mannose residues.	Polysaccharides	105-112	zymogen granule protein 16	Homo sapiens	161-166
25919894-6	2015	NMR results with docking simulations suggest a binding mode of ZG16p and PIM glycan; this will help to elucidate the physiological role of ZG16p.	Polysaccharides	77-83	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	73-76
25919894-6	2015	NMR results with docking simulations suggest a binding mode of ZG16p and PIM glycan; this will help to elucidate the physiological role of ZG16p.	Polysaccharides	77-83	zymogen granule protein 16	Homo sapiens	139-144
26233842-0	2015	Preventive effects of the polysaccharide of Larimichthys crocea swim bladder on carbon tetrachloride (CCl4)-induced hepatic damage.	Polysaccharides	26-40	C-C motif chemokine ligand 4	Rattus norvegicus	102-106
26044584-0	2015	ABO Blood Group as a Model for Platelet Glycan Modification in Arterial Thrombosis.	Polysaccharides	40-46	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	0-15
26173257-7	2015	Although galectins are key contributors to the formation of these extended glycan complexes leading to promotion of receptor segregation/clustering, and inhibition of receptor internalization by surface retention, when these complexes are disrupted, some galectins, particularly galectin-3 and -4, showed the ability to drive clathrin-independent mechanisms of endocytosis.	Polysaccharides	75-81	galectin 3	Homo sapiens	279-296
26233842-1	2015	The aim of the present study was to determine the preventive effects of the polysaccharide of Larimichthys crocea swim bladder (PLCSB) on CCl4-induced hepatic damage in ICR mice.	Polysaccharides	76-90	C-C motif chemokine ligand 4	Rattus norvegicus	138-142
25695948-0	2015	Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy.	Polysaccharides	77-91	keratin 5	Homo sapiens	74-76
25752299-2	2015	Previously, we described that a subfraction of the synaptic cell adhesion molecule SynCAM 1 is modified with the glycan polysialic acid (polySia) in NG2 cells.	Polysaccharides	113-119	cell adhesion molecule 1	Homo sapiens	83-91
25666751-0	2015	A polysaccharide from Trametes robiniophila Murrill induces apoptosis through intrinsic mitochondrial pathway in human osteosarcoma (U-2 OS) cells.	Polysaccharides	2-16	RNA, U2 small nuclear 4, pseudogene	Homo sapiens	133-136
25882296-7	2015	In light of the fact that dystroglycan functions as a matrix receptor and the polysaccharide synthesized by LARGE is the binding motif for matrix proteins, we propose to name this novel polysaccharide structure matriglycan.	Polysaccharides	186-200	dystroglycan 1	Homo sapiens	26-38
26019301-3	2015	It is shown here that silencing of the TAGL1 gene (RNA interference lines) promotes significant changes affecting cuticle development, mainly a reduction of thickness and stiffness, as well as a significant decrease in the content of cuticle components (cutin, waxes, polysaccharides, and phenolic compounds).	Polysaccharides	268-283	TAGL1 transcription factor	Solanum lycopersicum	39-44
25858314-2	2015	Since galectin-glycan interactions occur extracellularly, recombinant galectins are often used for the functional analysis of these interactions.	Polysaccharides	15-21	Galectin	Caenorhabditis elegans	6-14
25863146-5	2015	Here we report expression of CI-MPR"s CRD located in domain 5 that preferentially binds phosphodiester-containing glycans.	Polysaccharides	114-121	insulin like growth factor 2 receptor	Homo sapiens	29-35
25882296-0	2015	Matriglycan: a novel polysaccharide that links dystroglycan to the basement membrane.	Polysaccharides	21-35	dystroglycan 1	Homo sapiens	47-59
25882296-6	2015	In addition, we discuss the structure of the glycan that directly binds the ECM ligands and the mechanisms by which this functional motif is linked to dystroglycan.	Polysaccharides	45-51	dystroglycan 1	Homo sapiens	151-163
26003430-7	2015	We have previously shown that seminal plasma clusterin, but not serum clusterin, expresses an extreme abundance of fucosylated glycans.	Polysaccharides	127-134	clusterin	Homo sapiens	45-54
25878100-0	2015	Glycan Microheterogeneity at the PGT135 Antibody Recognition Site on HIV-1 gp120 Reveals a Molecular Mechanism for Neutralization Resistance.	Polysaccharides	0-6	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	75-80
25878100-3	2015	Here, site-specific glycosylation analysis of recombinant gp120 revealed glycan microheterogeneity sufficient to explain the existence of a minor population of virions resistant to PGT135 neutralization.	Polysaccharides	73-79	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	58-63
25737227-7	2015	Transcriptional profiling identified several glycosyl transferase genes, including CELLULOSE SYNTHASE-LIKE F10 (HvCslF10), which may contribute to differences in polysaccharide abundance between resistant and susceptible cultivars.	Polysaccharides	162-176	CslF10	Hordeum vulgare	112-120
26146060-0	2015	[Astragalus polysaccharides combined with cisplatin decreases the serum levels of CD44 and collagen type IV and hyaluronic acid in mice bearing Lewis lung cancer].	Polysaccharides	12-27	CD44 antigen	Mus musculus	82-86
25768892-2	2015	Since MVMp is an oncotropic virus, and galectin-3 is a multifunctional protein implicated in cancer metastasis, we hypothesized that galectin-3 and Mgat5, the Golgi enzyme that synthesizes high-affinity glycan ligands of galectin-3, might play a role in MVMp infection.	Polysaccharides	203-209	galectin 3	Homo sapiens	39-49
25970848-1	2015	Monoglucosylated high-mannose-type glycan (Glc1Man9GlcNAc2: G1M9) is well-known as a key glycoform in the glycoprotein folding process, which is specifically recognized by lectin chaperones calnexin (CNX) and calreticulin (CRT) in the endoplasmic reticulum (ER).	Polysaccharides	35-41	calnexin	Homo sapiens	190-198
25768892-2	2015	Since MVMp is an oncotropic virus, and galectin-3 is a multifunctional protein implicated in cancer metastasis, we hypothesized that galectin-3 and Mgat5, the Golgi enzyme that synthesizes high-affinity glycan ligands of galectin-3, might play a role in MVMp infection.	Polysaccharides	203-209	galectin 3	Homo sapiens	133-143
25768892-2	2015	Since MVMp is an oncotropic virus, and galectin-3 is a multifunctional protein implicated in cancer metastasis, we hypothesized that galectin-3 and Mgat5, the Golgi enzyme that synthesizes high-affinity glycan ligands of galectin-3, might play a role in MVMp infection.	Polysaccharides	203-209	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	148-153
25768892-2	2015	Since MVMp is an oncotropic virus, and galectin-3 is a multifunctional protein implicated in cancer metastasis, we hypothesized that galectin-3 and Mgat5, the Golgi enzyme that synthesizes high-affinity glycan ligands of galectin-3, might play a role in MVMp infection.	Polysaccharides	203-209	galectin 3	Homo sapiens	133-143
26157355-5	2015	However, little is known about the detailed glycan patterns of CEA.	Polysaccharides	44-50	CEA cell adhesion molecule 3	Homo sapiens	63-66
26157355-7	2015	The glycan patterns of CEA were then analyzed using a Matrix-Assisted Laser Desorption/Ionization-Time of Flight-Mass Spectrometry(3) (MALDI-TOF-MS(3)) approach.	Polysaccharides	4-10	CEA cell adhesion molecule 3	Homo sapiens	23-26
25970848-1	2015	Monoglucosylated high-mannose-type glycan (Glc1Man9GlcNAc2: G1M9) is well-known as a key glycoform in the glycoprotein folding process, which is specifically recognized by lectin chaperones calnexin (CNX) and calreticulin (CRT) in the endoplasmic reticulum (ER).	Polysaccharides	35-41	calnexin	Homo sapiens	200-203
25970848-1	2015	Monoglucosylated high-mannose-type glycan (Glc1Man9GlcNAc2: G1M9) is well-known as a key glycoform in the glycoprotein folding process, which is specifically recognized by lectin chaperones calnexin (CNX) and calreticulin (CRT) in the endoplasmic reticulum (ER).	Polysaccharides	35-41	calreticulin	Homo sapiens	209-221
25866187-6	2015	Furthermore, the EMT polysaccharides support the loading and release of the chondroinduction factor transforming growth factor beta3 (TGF-beta3).	Polysaccharides	21-36	IL2 inducible T cell kinase	Homo sapiens	17-20
25866187-6	2015	Furthermore, the EMT polysaccharides support the loading and release of the chondroinduction factor transforming growth factor beta3 (TGF-beta3).	Polysaccharides	21-36	transforming growth factor beta 3	Homo sapiens	100-132
26105115-3	2015	The unusually high glycan density on the gp120 subunit limits processing during biosynthesis, leaving a region of under-processed oligomannose-type structures, which is a primary target of these bnAbs.	Polysaccharides	19-25	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	41-46
25866187-6	2015	Furthermore, the EMT polysaccharides support the loading and release of the chondroinduction factor transforming growth factor beta3 (TGF-beta3).	Polysaccharides	21-36	transforming growth factor beta 3	Homo sapiens	134-143
25627693-5	2015	However, the protein moiety itself could not activate RAW264.7 cells, thus the complex formation of the polysaccharide and protein moieties in NF2 was pivotal to stimulate macrophage cells.	Polysaccharides	104-118	neurofibromin 2	Mus musculus	143-146
25855079-12	2015	These results unravel novel roles for N-glycosylation of ASBT and suggest that high levels of glucose alter the composition of the glycan and may contribute to the increase in ASBT function in diabetes mellitus.	Polysaccharides	131-137	solute carrier family 10 member 2	Homo sapiens	176-180
26601199-1	2015	The cereal cell wall polysaccharide (1-3,1-4)-beta-glucan is a linear polymer of glucose containing both beta1-3 and beta1-4 bonds.	Polysaccharides	21-35	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	105-112
26601199-1	2015	The cereal cell wall polysaccharide (1-3,1-4)-beta-glucan is a linear polymer of glucose containing both beta1-3 and beta1-4 bonds.	Polysaccharides	21-35	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	117-124
26601199-5	2015	A new mechanism for the control of the polysaccharide structure is proposed where membrane pore architecture and the translocation of the growing polysaccharide across the membrane control how the acceptor glucan is coordinated at the active site and thus the proportion of beta1-3 and beta1-4 bonds within the polysaccharide.	Polysaccharides	39-53	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	274-281
26601199-5	2015	A new mechanism for the control of the polysaccharide structure is proposed where membrane pore architecture and the translocation of the growing polysaccharide across the membrane control how the acceptor glucan is coordinated at the active site and thus the proportion of beta1-3 and beta1-4 bonds within the polysaccharide.	Polysaccharides	39-53	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	286-293
26601199-5	2015	A new mechanism for the control of the polysaccharide structure is proposed where membrane pore architecture and the translocation of the growing polysaccharide across the membrane control how the acceptor glucan is coordinated at the active site and thus the proportion of beta1-3 and beta1-4 bonds within the polysaccharide.	Polysaccharides	146-160	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	274-281
26601199-5	2015	A new mechanism for the control of the polysaccharide structure is proposed where membrane pore architecture and the translocation of the growing polysaccharide across the membrane control how the acceptor glucan is coordinated at the active site and thus the proportion of beta1-3 and beta1-4 bonds within the polysaccharide.	Polysaccharides	146-160	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	286-293
26601199-5	2015	A new mechanism for the control of the polysaccharide structure is proposed where membrane pore architecture and the translocation of the growing polysaccharide across the membrane control how the acceptor glucan is coordinated at the active site and thus the proportion of beta1-3 and beta1-4 bonds within the polysaccharide.	Polysaccharides	146-160	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	274-281
26601199-5	2015	A new mechanism for the control of the polysaccharide structure is proposed where membrane pore architecture and the translocation of the growing polysaccharide across the membrane control how the acceptor glucan is coordinated at the active site and thus the proportion of beta1-3 and beta1-4 bonds within the polysaccharide.	Polysaccharides	146-160	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	286-293
25855029-0	2015	Clusterin glycopeptide variant characterization reveals significant site-specific glycan changes in the plasma of clear cell renal cell carcinoma.	Polysaccharides	82-88	clusterin	Homo sapiens	0-9
25855029-8	2015	Removal of ccRCC led to a significant increase in the levels of both FA2G2S2 and A2G2S2 glycans in plasma clusterin.	Polysaccharides	88-95	clusterin	Homo sapiens	106-115
26019370-0	2015	Synthesis of a polymerizable, bivalent glycan mimetic of the HIV envelope spike gp120.	Polysaccharides	39-45	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	80-85
26019370-1	2015	A synthetic study on the creation of a bivalent, ROMP capable monomer has the ability to be polymerized into the corresponding neo-glycopolymer mimetic of the surface glycans on gp120 envelope spike of the HIV virus.	Polysaccharides	167-174	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	178-183
25450502-3	2015	In this work, we profiled the overall glycan pattern of human recombinant OPN using a lectin array and completed detailed structural analysis of O-glycopeptides by mass spectrometry (MS).	Polysaccharides	38-44	secreted phosphoprotein 1	Homo sapiens	74-77
25985274-2	2015	Of these, the PG9 antibody has a long heavy chain complementarity determining region 3 (HCDR3) and possesses unique structural elements that interact with protein and glycan features of the HIV Env glycoprotein.	Polysaccharides	167-173	endogenous retrovirus group K member 20	Homo sapiens	194-197
25985274-4	2015	One variant, designated PG9_N100(F)Y, possessed increased potency and was able to neutralize a diverse set of PG9-resistant HIV strains, including those lacking the Env N160 glycan, which is critical for PG9 binding.	Polysaccharides	174-180	endogenous retrovirus group K member 20	Homo sapiens	165-168
25769706-7	2015	By preventing the binding of HA to elastic fibers in COPD, lysozyme may interfere with the protective effect of this polysaccharide against enzymes and oxidants that degrade these fibers.	Polysaccharides	117-131	lysozyme	Homo sapiens	59-67
25935482-0	2015	The relationship between glycan structures and expression levels of an endoplasmic reticulum-resident glycoprotein, UDP-glucose: Glycoprotein glucosyltransferase 1.	Polysaccharides	25-31	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	116-163
25935482-1	2015	In this article, we report a relationship between glycan structures and expression levels of a recombinant ER-resident glycoprotein, uridine 5"-diphosphate-glucose: glycoprotein glucosyltransferase (UGGT1).	Polysaccharides	50-56	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	199-204
26051934-2	2015	The high density and heterogeneity of the glycans shield Env from recognition by the immune system, but paradoxically, many potent broadly neutralizing antibodies (bNAbs) recognize epitopes involving this glycan shield.	Polysaccharides	42-49	endogenous retrovirus group K member 20	Homo sapiens	57-60
26051934-2	2015	The high density and heterogeneity of the glycans shield Env from recognition by the immune system, but paradoxically, many potent broadly neutralizing antibodies (bNAbs) recognize epitopes involving this glycan shield.	Polysaccharides	42-48	endogenous retrovirus group K member 20	Homo sapiens	57-60
26051934-7	2015	A homogeneous, oligomannose-dominated glycan profile is therefore a hallmark of a native Env conformation and a potential Achilles" heel that can be exploited for bNAb recognition and vaccine design.	Polysaccharides	38-44	endogenous retrovirus group K member 20	Homo sapiens	89-92
25938165-3	2015	We used a database of glycan array data to identify the lectins CCL2 to detect glycan motifs with fucose in a 3" linkage; CGL2 for motifs with fucose in a 2" linkage; and RSL for fucose in all linkages.	Polysaccharides	22-28	C-C motif chemokine ligand 2	Homo sapiens	64-68
25938165-3	2015	We used a database of glycan array data to identify the lectins CCL2 to detect glycan motifs with fucose in a 3" linkage; CGL2 for motifs with fucose in a 2" linkage; and RSL for fucose in all linkages.	Polysaccharides	79-85	C-C motif chemokine ligand 2	Homo sapiens	64-68
25872915-12	2015	mAbs produced in murine myeloma cells such as NS0 and SP2/0 contain glycans such as Galalpha1-3Galbeta1-4N-acetylglucosamine-R and N-glycolylneuraminic acid (NGNA) that are not naturally present in humans and can be immunogenic when used as therapeutics.	Polysaccharides	68-75	Sp2 transcription factor	Mus musculus	54-59
26069953-17	2015	Treatment with R. tanguticum polysaccharide 1 plus 5-amino salicylic acid markedly decreased nuclear factor-kappa Bp65 and tumor necrosis factor-alpha protein expressions.	Polysaccharides	29-43	Blood pressure QTL 65	Rattus norvegicus	114-118
26137135-0	2015	Scutellaria barbata D. Don polysaccharides inhibit the growth of Calu-3 xenograft tumors via suppression of the HER2 pathway and angiogenesis.	Polysaccharides	27-42	erb-b2 receptor tyrosine kinase 2	Homo sapiens	112-116
26069953-20	2015	These results demonstrate that combined therapy with R. tanguticum polysaccharide 1 and low-dose 5-amino salicylic acid had more favorable effects on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats, and its effects may be associated with inhibiting nuclear factor-kappa Bp65 protein expression and tumor necrosis factor-alpha production, resulting in a decrease of cyclooxygenase 2 and inducible nitric oxide synthase protein expressions.	Polysaccharides	67-81	Blood pressure QTL 65	Rattus norvegicus	282-286
26069953-17	2015	Treatment with R. tanguticum polysaccharide 1 plus 5-amino salicylic acid markedly decreased nuclear factor-kappa Bp65 and tumor necrosis factor-alpha protein expressions.	Polysaccharides	29-43	tumor necrosis factor	Rattus norvegicus	123-150
26069953-20	2015	These results demonstrate that combined therapy with R. tanguticum polysaccharide 1 and low-dose 5-amino salicylic acid had more favorable effects on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats, and its effects may be associated with inhibiting nuclear factor-kappa Bp65 protein expression and tumor necrosis factor-alpha production, resulting in a decrease of cyclooxygenase 2 and inducible nitric oxide synthase protein expressions.	Polysaccharides	67-81	tumor necrosis factor	Rattus norvegicus	310-337
26069953-20	2015	These results demonstrate that combined therapy with R. tanguticum polysaccharide 1 and low-dose 5-amino salicylic acid had more favorable effects on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats, and its effects may be associated with inhibiting nuclear factor-kappa Bp65 protein expression and tumor necrosis factor-alpha production, resulting in a decrease of cyclooxygenase 2 and inducible nitric oxide synthase protein expressions.	Polysaccharides	67-81	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	377-393
26069953-18	2015	R. tanguticum polysaccharide 1 and 5-amino salicylic acid had no effect on cyclooxygenase 1 protein expression, but inhibited the overexpression of the cyclooxygenase 2 protein.	Polysaccharides	14-28	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	152-168
25907408-3	2015	As a step towards developing a cost effective and more immunogenic Hib conjugate vaccine, we present a method for the preparation of Hib capsular polysaccharide (PRP)-tetanus toxoid (TT) conjugates using optimized PRP chain length and conjugation conditions.	Polysaccharides	146-160	proline rich protein 2-like 1	Rattus norvegicus	162-165
26023780-0	2015	Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site.	Polysaccharides	92-98	T-cell surface glycoprotein CD4	Oryctolagus cuniculus	133-136
26023780-7	2015	Neutralizing sera targeted epitopes that overlap with the CD4 binding site, consistent with the role of the N197 glycan in a putative "glycan fence" that limits access to this region.	Polysaccharides	135-141	T-cell surface glycoprotein CD4	Oryctolagus cuniculus	58-61
25817657-1	2015	Alginate is a linear and acidic polysaccharide, composed of (1   4) linked beta-D-mannuronic acid (ManA) and alpha-L-guluronic acid (GulA).	Polysaccharides	32-46	mannosidase alpha class 2C member 1	Homo sapiens	75-97
25894217-1	2015	Heparin is a highly sulfated, long, and linear polysaccharide, which can inhibit tumor growth by interacting with growth factors such as bFGF and VEGF.	Polysaccharides	47-61	fibroblast growth factor 2	Homo sapiens	137-141
25894217-1	2015	Heparin is a highly sulfated, long, and linear polysaccharide, which can inhibit tumor growth by interacting with growth factors such as bFGF and VEGF.	Polysaccharides	47-61	vascular endothelial growth factor A	Homo sapiens	146-150
25951175-4	2015	These glycans can be carried on many mucin-type glycoproteins including MUC1.	Polysaccharides	6-13	LOC100508689	Homo sapiens	37-42
25870292-1	2015	The antiinflammatory activity of intravenous immunoglobulin (IVIG) is dependent on the presence of sialic acid in the core IgG fragment crystallizable domain (Fc) glycan, resulting in increased conformational flexibility of the CH2 domain with corresponding modulation of Fc receptor (FcR) binding specificity from type I to type II receptors.	Polysaccharides	163-169	Fc receptor	Mus musculus	272-283
25870292-1	2015	The antiinflammatory activity of intravenous immunoglobulin (IVIG) is dependent on the presence of sialic acid in the core IgG fragment crystallizable domain (Fc) glycan, resulting in increased conformational flexibility of the CH2 domain with corresponding modulation of Fc receptor (FcR) binding specificity from type I to type II receptors.	Polysaccharides	163-169	Fc receptor	Mus musculus	285-288
25901321-6	2015	To illustrate this, we show how the superselective targeting of the extracellular matrix polysaccharide hyaluronan to its main cell surface receptor CD44 is controlled by the affinity of individual CD44-hyaluronan interactions.	Polysaccharides	89-103	CD44 molecule (Indian blood group)	Homo sapiens	149-153
25901321-6	2015	To illustrate this, we show how the superselective targeting of the extracellular matrix polysaccharide hyaluronan to its main cell surface receptor CD44 is controlled by the affinity of individual CD44-hyaluronan interactions.	Polysaccharides	89-103	CD44 molecule (Indian blood group)	Homo sapiens	198-202
25901322-6	2015	In senju mutants, reduced expression of galactose-containing glycans resulted in hyperactivation of the Toll signaling pathway in the absence of immune challenges.	Polysaccharides	61-68	Toll	Drosophila melanogaster	104-108
25901322-8	2015	Interestingly, Toll activation in immune-challenged wild type (WT) flies reduced the expression of galactose-containing glycans.	Polysaccharides	120-127	Toll	Drosophila melanogaster	15-19
25735801-7	2015	Dose-dependent therapeutic effects further demonstrated that the CDDP-loaded LHRH-decorated polysaccharide nanoparticles significantly enhanced the antitumor and antimetastasis efficacy, as compared to the non-targeted nanoparticles.	Polysaccharides	92-106	gonadotropin releasing hormone 1	Homo sapiens	77-81
25817687-3	2015	In the present study, two polysaccharide fractions, SGP-1 and SGP-2, were isolated from the rhizomes of S. glabra with the number average molecular weights of 1.72 x 10(2)kDa and 1.31 x 10(2)kDa, and the weight average molecular weights of 1.31 x 10(5)kDa and 1.18 x 10(5)kDa, respectively, and their mainly monosaccharide compositions were both galactose and rhamnose (2.5:1).	Polysaccharides	26-40	serum gp70 production 1	Mus musculus	52-57
25817687-3	2015	In the present study, two polysaccharide fractions, SGP-1 and SGP-2, were isolated from the rhizomes of S. glabra with the number average molecular weights of 1.72 x 10(2)kDa and 1.31 x 10(2)kDa, and the weight average molecular weights of 1.31 x 10(5)kDa and 1.18 x 10(5)kDa, respectively, and their mainly monosaccharide compositions were both galactose and rhamnose (2.5:1).	Polysaccharides	26-40	serum gp70 production 2	Mus musculus	62-67
25695518-2	2015	DBPA facilitates the bacteria"s colonization of human tissue by adhering to glycosaminoglycan (GAG), a sulfated polysaccharide.	Polysaccharides	112-126	Y-box binding protein 3	Homo sapiens	0-4
25951175-4	2015	These glycans can be carried on many mucin-type glycoproteins including MUC1.	Polysaccharides	6-13	mucin 1, cell surface associated	Homo sapiens	72-76
25689620-10	2015	These findings corroborate the potential role of glycan inhibitors of galectin-3 as a therapeutic approach for the treatment of inflammatory arthritis.	Polysaccharides	49-55	galectin 3	Homo sapiens	70-80
25880160-0	2015	Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-alpha/PGC-1alpha signaling mediated energy biosynthesis.	Polysaccharides	11-25	tumor necrosis factor	Rattus norvegicus	93-102
25880160-0	2015	Astragalus polysaccharide attenuates isoproterenol-induced cardiac hypertrophy by regulating TNF-alpha/PGC-1alpha signaling mediated energy biosynthesis.	Polysaccharides	11-25	PPARG coactivator 1 alpha	Rattus norvegicus	103-113
25087735-0	2015	Immunomodulation of cystic fibrosis epithelial cells via NF-kappaB decoy oligonucleotide-coated polysaccharide nanoparticles.	Polysaccharides	96-110	nuclear factor kappa B subunit 1	Homo sapiens	57-66
25702281-9	2015	Thus, Fuc-PON1 may serve as a glycan biomarker for distinguishing early HCC from LC patients even with low AFP levels.	Polysaccharides	30-36	paraoxonase 1	Homo sapiens	6-14
25497369-0	2015	Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.	Polysaccharides	31-38	sialic acid binding Ig-like lectin F	Mus musculus	49-57
25497369-3	2015	Siglec-F recognizes sialylated sulfated glycans in glycan-binding assays, but the identities of endogenous sialoside ligands and their glycoprotein carriers in vivo are unknown.	Polysaccharides	40-47	sialic acid binding Ig-like lectin F	Mus musculus	0-8
25497369-3	2015	Siglec-F recognizes sialylated sulfated glycans in glycan-binding assays, but the identities of endogenous sialoside ligands and their glycoprotein carriers in vivo are unknown.	Polysaccharides	40-46	sialic acid binding Ig-like lectin F	Mus musculus	0-8
25497369-4	2015	OBJECTIVES: To use mouse lung-derived materials to isolate, biochemically identify, and biologically characterize naturally occurring endogenous glycan ligands for Siglec-F.	Polysaccharides	145-151	sialic acid binding Ig-like lectin F	Mus musculus	164-172
25730103-8	2015	Closer examination revealed the preference for larger (in terms of total monosaccharide count) and more sialylated glycan structures in the MYCN-amplified samples in comparison to smaller, nonsialylated glycans that are more dominant in the MYCN-nonamplified samples.	Polysaccharides	115-121	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	140-144
25497369-13	2015	CONCLUSIONS: These data identify a previously unrecognized endogenous anti-inflammatory property of airway mucins by which their glycans can control lung eosinophilia through engagement of Siglec-F.	Polysaccharides	129-136	sialic acid binding Ig-like lectin F	Mus musculus	189-197
25795779-1	2015	In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space.	Polysaccharides	256-270	hyaluronan synthase 1	Homo sapiens	101-124
25795779-1	2015	In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar substrates by hyaluronan synthase 1-3 (HAS1-3) isoenzymes that transfer N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcUA) in alternative positions in the growing polysaccharide chain during its simultaneous extrusion into the extracellular space.	Polysaccharides	256-270	hyaluronan synthase 1	Homo sapiens	126-132
26159026-17	2015	Compared with the model group, the expression of cortical Syt-1 increased in the saponin group and the benzene group; the expression of cortical IL-1beta increased in the benzene group and the polysaccharide group; the expression of hippocampal GFAP increased in the three kinds extracts of QKR groups; expression levels of Syt-1, IL-1beta, GFAP, and beta-APP in the cortex and hippocampus decreased in the rest treatment groups (all P < 0.05, P < 0.01).	Polysaccharides	193-207	interleukin 1 alpha	Rattus norvegicus	145-153
25673720-5	2015	PrP(C) is posttranslationally modified by the addition of glycan moieties which have an important role in the infectious process.	Polysaccharides	58-64	prion protein	Mus musculus	0-6
25875794-5	2015	Multivariate analysis revealed that a high glycan 9200 concentration was an independent risk factor for shorter TTP (hazard ratio, 2.11; 95% confidence interval, 1.07-4.17) and poor overall survival (hazard ratio, 2.56; 95% confidence interval, 1.08-6.19).	Polysaccharides	43-49	ZFP36 ring finger protein	Homo sapiens	112-115
25481681-1	2015	UGGT1 is called as a folding sensor protein that recognizes misfolded glycoproteins and selectively glucosylates high-mannose-type glycans on the proteins.	Polysaccharides	131-138	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	0-5
25481681-3	2015	We have demonstrated that high-mannose-type glycans, in which various hydrophobic aglycons were introduced, act as good substrates for UGGT1 and are useful analytical tools for its characterization.	Polysaccharides	44-51	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	135-140
26255523-0	2015	[Effects of electroacupuncture combined with polysaccharide of gastrodia elate blume on expression of nestin and stem cell factor in thalamic ventroposterolateral nucleus in rats with focal cerebral ischemia].	Polysaccharides	45-59	nestin	Rattus norvegicus	102-108
26255523-0	2015	[Effects of electroacupuncture combined with polysaccharide of gastrodia elate blume on expression of nestin and stem cell factor in thalamic ventroposterolateral nucleus in rats with focal cerebral ischemia].	Polysaccharides	45-59	KIT ligand	Rattus norvegicus	113-129
25389233-14	2015	Two putative mechanisms may contribute to the increased exposure of these glycans: (1) the canonical N-glycosylation site of the IgG-CH2 domain; (2) an IgG binding non-IgG molecule, like complement or C-reactive protein.	Polysaccharides	74-81	C-reactive protein	Homo sapiens	201-219
25633186-10	2015	Results suggest a possible route of Lp(a) attachment to vascular cells that offer terminal galactose on surface glycans following desialylation.	Polysaccharides	112-119	lipoprotein(a)	Homo sapiens	36-41
25919275-8	2015	In this review, we describe the findings on the role of ST6Gal I in cancer progression, and highlight in particular the knowledge of how ST6Gal I-mediated alpha2,6 sialylated glycans or sialylated carrier proteins regulate cell signaling to promote the malignant phenotype of human carcinoma.	Polysaccharides	175-182	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	137-145
25752613-2	2015	Heparan sulfate, a sulfated linear polysaccharide modified in a complex variety of ways, serves as an essential co-receptor in Slit-Robo signaling.	Polysaccharides	35-49	roundabout 1	Drosophila melanogaster	132-136
26212272-5	2015	RESULTS: Glycans were released from GSL standards comprising of ganglio-, asialo-ganglio- and the relatively resistant globo-series glycans, using as little as 1 mU of enzyme and 2 microg of GSL.	Polysaccharides	9-16	cathepsin A	Homo sapiens	36-39
25895751-0	2015	Genome-wide next-generation DNA and RNA sequencing reveals a mutation that perturbs splicing of the phosphatidylinositol glycan anchor biosynthesis class H gene (PIGH) and causes arthrogryposis in Belgian Blue cattle.	Polysaccharides	121-127	phosphatidylinositol glycan anchor biosynthesis class H	Bos taurus	162-166
25875017-0	2015	Neofunctionalization of the Sec1 alpha1,2fucosyltransferase paralogue in leporids contributes to glycan polymorphism and resistance to rabbit hemorrhagic disease virus.	Polysaccharides	97-103	secretory blood group 1	Rattus norvegicus	28-32
25875017-0	2015	Neofunctionalization of the Sec1 alpha1,2fucosyltransferase paralogue in leporids contributes to glycan polymorphism and resistance to rabbit hemorrhagic disease virus.	Polysaccharides	97-103	fucosyltransferase 2	Homo sapiens	33-59
25875017-3	2015	Synthesis of these glycans requires an alpha1,2fucosyltransferase.	Polysaccharides	19-26	fucosyltransferase 2	Homo sapiens	39-65
25875017-15	2015	Thus, in leporids, unlike in most other mammals where it became extinct, Sec1 evolved a new function with a dominant-negative effect on rFut1, contributing to fucosylated glycan diversity, and allowing herd protection from pathogens such as RHDV.	Polysaccharides	171-177	secretory blood group 1	Rattus norvegicus	73-77
25897665-5	2015	Remarkably, interaction of SEA glycans with DCs results in a strongly increased expression of Suppressor Of Cytokine Signalling1 (SOCS1) and SH2-containing protein tyrosine Phosphatase-1 (SHP1), important negative regulators of TLR4 signalling.	Polysaccharides	31-38	suppressor of cytokine signaling 1	Homo sapiens	94-128
25897665-5	2015	Remarkably, interaction of SEA glycans with DCs results in a strongly increased expression of Suppressor Of Cytokine Signalling1 (SOCS1) and SH2-containing protein tyrosine Phosphatase-1 (SHP1), important negative regulators of TLR4 signalling.	Polysaccharides	31-38	suppressor of cytokine signaling 1	Homo sapiens	130-135
25897665-5	2015	Remarkably, interaction of SEA glycans with DCs results in a strongly increased expression of Suppressor Of Cytokine Signalling1 (SOCS1) and SH2-containing protein tyrosine Phosphatase-1 (SHP1), important negative regulators of TLR4 signalling.	Polysaccharides	31-38	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	188-192
25897665-5	2015	Remarkably, interaction of SEA glycans with DCs results in a strongly increased expression of Suppressor Of Cytokine Signalling1 (SOCS1) and SH2-containing protein tyrosine Phosphatase-1 (SHP1), important negative regulators of TLR4 signalling.	Polysaccharides	31-38	toll like receptor 4	Homo sapiens	228-232
25897665-8	2015	In conclusion, we demonstrate that SEA glycans are essential for induction of enhanced SOCS1 and SHP1 levels in DCs via the MR. Our data provide novel mechanistic evidence for the potential of S. mansoni SEA glycans to modulate human DCs, which may contribute to the capacity of SEA to down-regulate inflammatory responses.	Polysaccharides	39-46	suppressor of cytokine signaling 1	Homo sapiens	87-92
25897665-8	2015	In conclusion, we demonstrate that SEA glycans are essential for induction of enhanced SOCS1 and SHP1 levels in DCs via the MR. Our data provide novel mechanistic evidence for the potential of S. mansoni SEA glycans to modulate human DCs, which may contribute to the capacity of SEA to down-regulate inflammatory responses.	Polysaccharides	39-46	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	97-101
25897665-8	2015	In conclusion, we demonstrate that SEA glycans are essential for induction of enhanced SOCS1 and SHP1 levels in DCs via the MR. Our data provide novel mechanistic evidence for the potential of S. mansoni SEA glycans to modulate human DCs, which may contribute to the capacity of SEA to down-regulate inflammatory responses.	Polysaccharides	208-215	suppressor of cytokine signaling 1	Homo sapiens	87-92
25897665-8	2015	In conclusion, we demonstrate that SEA glycans are essential for induction of enhanced SOCS1 and SHP1 levels in DCs via the MR. Our data provide novel mechanistic evidence for the potential of S. mansoni SEA glycans to modulate human DCs, which may contribute to the capacity of SEA to down-regulate inflammatory responses.	Polysaccharides	208-215	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	97-101
25884549-6	2015	Sequence alignment reveals that these residues are conserved in a wide range of mammalian species, suggesting that mincle has a conserved function in binding ligands that may include endogenous mammalian glycans or pathogen glycans in addition to trehalose dimycolate.	Polysaccharides	204-211	C-type lectin domain family 4 member E	Homo sapiens	115-121
25884549-6	2015	Sequence alignment reveals that these residues are conserved in a wide range of mammalian species, suggesting that mincle has a conserved function in binding ligands that may include endogenous mammalian glycans or pathogen glycans in addition to trehalose dimycolate.	Polysaccharides	224-231	C-type lectin domain family 4 member E	Homo sapiens	115-121
25873380-3	2015	We characterized the glycans of Flo1p and their role in this binding process and demonstrate that glycan-glycan interactions significantly contribute to the cell-cell adhesion mechanism.	Polysaccharides	21-28	flocculin FLO1	Saccharomyces cerevisiae S288C	32-37
26212272-5	2015	RESULTS: Glycans were released from GSL standards comprising of ganglio-, asialo-ganglio- and the relatively resistant globo-series glycans, using as little as 1 mU of enzyme and 2 microg of GSL.	Polysaccharides	9-16	cathepsin A	Homo sapiens	191-194
26212272-5	2015	RESULTS: Glycans were released from GSL standards comprising of ganglio-, asialo-ganglio- and the relatively resistant globo-series glycans, using as little as 1 mU of enzyme and 2 microg of GSL.	Polysaccharides	132-139	cathepsin A	Homo sapiens	36-39
26212272-8	2015	CONCLUSION: We describe a relatively simple, detergent-free, enzymatic release of glycans from PVDF-immobilized GSLs, followed by the detailed structural analysis afforded by PGC-LC-ESI-MS/MS, to offer a versatile method for the analysis of tumour and cell-derived GSL-glycans.	Polysaccharides	82-89	cathepsin A	Homo sapiens	112-115
24882581-1	2015	The previous studies in this lab discovered that microRNA-885-3p (miR-885-3p) was regulated by a sulfated polysaccharide that bound to bone morphogenetic protein receptor, type IA (BMPR1A) to inhibit angiogenesis.	Polysaccharides	106-120	bone morphogenetic protein receptor type 1A	Homo sapiens	135-179
25656175-0	2015	Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens.	Polysaccharides	93-99	CD207 molecule	Homo sapiens	27-35
25656175-0	2015	Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens.	Polysaccharides	93-99	CD209 molecule	Homo sapiens	40-47
25658063-0	2015	Capsular polysaccharide conformations in pneumococcal serotypes 19F and 19A.	Polysaccharides	9-23	SLAM family member 7	Homo sapiens	72-75
25658063-4	2015	In the solution simulations of 19F and 19A oligosaccharide chains reported here, both polysaccharides form unstructured random coils, with inflexible repeat units linked by mobile phosphodiester linkages.	Polysaccharides	86-101	SLAM family member 7	Homo sapiens	39-42
24882581-1	2015	The previous studies in this lab discovered that microRNA-885-3p (miR-885-3p) was regulated by a sulfated polysaccharide that bound to bone morphogenetic protein receptor, type IA (BMPR1A) to inhibit angiogenesis.	Polysaccharides	106-120	bone morphogenetic protein receptor type 1A	Homo sapiens	181-187
25824821-0	2015	A single glycan on IgE is indispensable for initiation of anaphylaxis.	Polysaccharides	9-15	immunoglobulin heavy constant epsilon	Homo sapiens	19-22
25735895-8	2015	Therefore, Ac4ManNCp is a powerful probe for efficient and rapid MOE and it may find wide applications in the labelling of glycans.	Polysaccharides	123-130	immunoglobulin kappa variable 4-63	Mus musculus	11-14
25824821-7	2015	The obligatory glycan was mapped to a single N-linked oligomannose structure in the constant domain 3 (Cepsilon3) of IgE, at asparagine-394 (N394) in human IgE and N384 in mouse.	Polysaccharides	15-21	immunoglobulin heavy constant epsilon	Homo sapiens	117-120
25824821-7	2015	The obligatory glycan was mapped to a single N-linked oligomannose structure in the constant domain 3 (Cepsilon3) of IgE, at asparagine-394 (N394) in human IgE and N384 in mouse.	Polysaccharides	15-21	immunoglobulin heavy constant epsilon	Homo sapiens	156-159
25604055-0	2015	Paradigm shift in activity assessment of IgA nephropathy - optimizing the next generation of diagnostic and therapeutic maneuvers via glycan targeting.	Polysaccharides	134-140	IGAN1	Homo sapiens	41-56
25701032-9	2015	Both nature of the polysaccharide and SD were important properties that influenced the adsorption of PL, vascular endothelial growth factor (VEGF), fibroblast growth factor b (FGFb) and platelet derived growth factor (PDGF).	Polysaccharides	19-33	vascular endothelial growth factor A	Homo sapiens	105-139
25701032-9	2015	Both nature of the polysaccharide and SD were important properties that influenced the adsorption of PL, vascular endothelial growth factor (VEGF), fibroblast growth factor b (FGFb) and platelet derived growth factor (PDGF).	Polysaccharides	19-33	vascular endothelial growth factor A	Homo sapiens	141-145
25701032-9	2015	Both nature of the polysaccharide and SD were important properties that influenced the adsorption of PL, vascular endothelial growth factor (VEGF), fibroblast growth factor b (FGFb) and platelet derived growth factor (PDGF).	Polysaccharides	19-33	fibroblast growth factor 2	Homo sapiens	148-174
25701032-9	2015	Both nature of the polysaccharide and SD were important properties that influenced the adsorption of PL, vascular endothelial growth factor (VEGF), fibroblast growth factor b (FGFb) and platelet derived growth factor (PDGF).	Polysaccharides	19-33	fibroblast growth factor 2	Homo sapiens	176-180
25604055-3	2015	However, recent evidence revealed that aberrantly glycosylated serum IgA1, mostly galactose-deficient IgA1 (Gd-IgA1) and immune complexes (ICs) with autoantibodies against glycan-containing epitopes on Gd-IgA1 are essential effector molecules.	Polysaccharides	172-178	immunoglobulin heavy constant alpha 1	Homo sapiens	69-73
25604055-5	2015	We summarize the characteristics and molecular basis of Gd-IgA1 and related ICs, their clinical application for activity assessment and early diagnosis, and discuss glycan as a potent target of therapeutic agents based on glycan engineering in IgAN.	Polysaccharides	165-171	IGAN1	Homo sapiens	244-248
25604055-5	2015	We summarize the characteristics and molecular basis of Gd-IgA1 and related ICs, their clinical application for activity assessment and early diagnosis, and discuss glycan as a potent target of therapeutic agents based on glycan engineering in IgAN.	Polysaccharides	222-228	IGAN1	Homo sapiens	244-248
25604055-8	2015	Early screening and diagnosis may increase therapeutic options, including quantitative regulation of nephritogenic Gd-IgA1 using therapeutic antibodies and selective depletion of Gd-IgA1-producing cells via glycan engineering.	Polysaccharides	207-213	immunoglobulin heavy constant alpha 1	Homo sapiens	182-186
25300290-3	2015	We previously reported that diabetes not only causes an increase of UT-A1 protein abundance but also, results in UT-A1 glycan changes, including an increase of sialic acid content.	Polysaccharides	119-125	solute carrier family 14 (urea transporter), member 2	Mus musculus	113-118
25347992-6	2015	These findings reveal that bacterial polysaccharides link the microbiota with the peripheral immune system by activating CD4(+)Foxp3(-) T cells upon exposure in the gut, and they facilitate resistance to unnecessary inflammatory responses via the production of IL-10.	Polysaccharides	37-52	CD4 antigen	Mus musculus	121-124
25347992-6	2015	These findings reveal that bacterial polysaccharides link the microbiota with the peripheral immune system by activating CD4(+)Foxp3(-) T cells upon exposure in the gut, and they facilitate resistance to unnecessary inflammatory responses via the production of IL-10.	Polysaccharides	37-52	forkhead box P3	Mus musculus	127-132
25347992-6	2015	These findings reveal that bacterial polysaccharides link the microbiota with the peripheral immune system by activating CD4(+)Foxp3(-) T cells upon exposure in the gut, and they facilitate resistance to unnecessary inflammatory responses via the production of IL-10.	Polysaccharides	37-52	interleukin 10	Mus musculus	261-266
25361541-0	2015	Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTPbeta.	Polysaccharides	6-12	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	123-133
25361541-0	2015	Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTPbeta.	Polysaccharides	6-12	protein tyrosine phosphatase, receptor type, B	Mus musculus	134-142
25361541-8	2015	We also showed that the Lewis X epitope almost disappeared due to the knockout of protein O-mannose beta1,2-N-acetylglucosaminyltransferase 1, an N-acetylglucosaminyltransferase essential for the synthesis of O-mannosylated glycans, which indicated that the O-mannosylated glycan is responsible for presenting the Lewis X epitope.	Polysaccharides	224-231	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	Mus musculus	108-139
25361541-8	2015	We also showed that the Lewis X epitope almost disappeared due to the knockout of protein O-mannose beta1,2-N-acetylglucosaminyltransferase 1, an N-acetylglucosaminyltransferase essential for the synthesis of O-mannosylated glycans, which indicated that the O-mannosylated glycan is responsible for presenting the Lewis X epitope.	Polysaccharides	224-231	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	Mus musculus	146-177
25361541-9	2015	Since O-mannosylated glycans on phosphacan/RPTPbeta could also present human natural killer-1, another glycan epitope specifically expressed in the nervous system, our results revealed the importance of O-mannosylated glycan chains in the presentation of functional glycan epitopes in the brain.	Polysaccharides	21-28	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	32-42
25361541-9	2015	Since O-mannosylated glycans on phosphacan/RPTPbeta could also present human natural killer-1, another glycan epitope specifically expressed in the nervous system, our results revealed the importance of O-mannosylated glycan chains in the presentation of functional glycan epitopes in the brain.	Polysaccharides	21-28	protein tyrosine phosphatase receptor type Z1	Homo sapiens	43-51
25361541-9	2015	Since O-mannosylated glycans on phosphacan/RPTPbeta could also present human natural killer-1, another glycan epitope specifically expressed in the nervous system, our results revealed the importance of O-mannosylated glycan chains in the presentation of functional glycan epitopes in the brain.	Polysaccharides	21-27	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	32-42
25361541-9	2015	Since O-mannosylated glycans on phosphacan/RPTPbeta could also present human natural killer-1, another glycan epitope specifically expressed in the nervous system, our results revealed the importance of O-mannosylated glycan chains in the presentation of functional glycan epitopes in the brain.	Polysaccharides	21-27	protein tyrosine phosphatase receptor type Z1	Homo sapiens	43-51
25361541-9	2015	Since O-mannosylated glycans on phosphacan/RPTPbeta could also present human natural killer-1, another glycan epitope specifically expressed in the nervous system, our results revealed the importance of O-mannosylated glycan chains in the presentation of functional glycan epitopes in the brain.	Polysaccharides	103-109	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	32-42
25361541-9	2015	Since O-mannosylated glycans on phosphacan/RPTPbeta could also present human natural killer-1, another glycan epitope specifically expressed in the nervous system, our results revealed the importance of O-mannosylated glycan chains in the presentation of functional glycan epitopes in the brain.	Polysaccharides	103-109	protein tyrosine phosphatase receptor type Z1	Homo sapiens	43-51
25361541-9	2015	Since O-mannosylated glycans on phosphacan/RPTPbeta could also present human natural killer-1, another glycan epitope specifically expressed in the nervous system, our results revealed the importance of O-mannosylated glycan chains in the presentation of functional glycan epitopes in the brain.	Polysaccharides	103-109	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	32-42
25361541-9	2015	Since O-mannosylated glycans on phosphacan/RPTPbeta could also present human natural killer-1, another glycan epitope specifically expressed in the nervous system, our results revealed the importance of O-mannosylated glycan chains in the presentation of functional glycan epitopes in the brain.	Polysaccharides	103-109	protein tyrosine phosphatase receptor type Z1	Homo sapiens	43-51
25300290-10	2015	Thus, our results reveal a novel mechanism by which PKC regulates UT-A1 function by increasing glycan sialylation through Src kinase pathways, which may have an important role in preventing the osmotic diuresis caused by glucosuria under diabetic conditions.	Polysaccharides	95-101	solute carrier family 14 (urea transporter), member 2	Mus musculus	66-71
25100662-0	2015	BMP-2 encapsulated polysaccharide nanoparticle modified biphasic calcium phosphate scaffolds for bone tissue regeneration.	Polysaccharides	19-33	bone morphogenetic protein 2	Oryctolagus cuniculus	0-5
25100662-9	2015	Both the in vitro and in vivo results demonstrate that BMP-2 encapsulated polysaccharide NPs are effective to improve the osteoinductivity of the scaffolds.	Polysaccharides	74-88	bone morphogenetic protein 2	Oryctolagus cuniculus	55-60
25300290-5	2015	We found that activation of PKC specifically promotes UT-A1 glycan sialylation in both UT-A1-MDCK cells and rat kidney inner medullary collecting duct suspensions, and inhibition of PKC activity blocks high glucose-induced UT-A1 sialylation.	Polysaccharides	60-66	protein kinase C, gamma	Rattus norvegicus	28-31
25300290-5	2015	We found that activation of PKC specifically promotes UT-A1 glycan sialylation in both UT-A1-MDCK cells and rat kidney inner medullary collecting duct suspensions, and inhibition of PKC activity blocks high glucose-induced UT-A1 sialylation.	Polysaccharides	60-66	solute carrier family 14 (urea transporter), member 2	Mus musculus	54-59
25300290-5	2015	We found that activation of PKC specifically promotes UT-A1 glycan sialylation in both UT-A1-MDCK cells and rat kidney inner medullary collecting duct suspensions, and inhibition of PKC activity blocks high glucose-induced UT-A1 sialylation.	Polysaccharides	60-66	solute carrier family 14 (urea transporter), member 2	Mus musculus	87-92
25300290-5	2015	We found that activation of PKC specifically promotes UT-A1 glycan sialylation in both UT-A1-MDCK cells and rat kidney inner medullary collecting duct suspensions, and inhibition of PKC activity blocks high glucose-induced UT-A1 sialylation.	Polysaccharides	60-66	solute carrier family 14 (urea transporter), member 2	Mus musculus	87-92
25449758-9	2015	This work showed that PglB protein might be able to accommodate the transfer of the further engineered glycan with greater complexity.	Polysaccharides	103-109	epiphycan	Homo sapiens	22-26
25300290-10	2015	Thus, our results reveal a novel mechanism by which PKC regulates UT-A1 function by increasing glycan sialylation through Src kinase pathways, which may have an important role in preventing the osmotic diuresis caused by glucosuria under diabetic conditions.	Polysaccharides	95-101	protein kinase C, gamma	Rattus norvegicus	52-55
25108744-14	2015	It is proposed that H2O2 and apoplastic peroxidase cross-link secreted glycoproteins and polysaccharides to agglutinate the hrp mutant.	Polysaccharides	89-104	peroxidase	Arabidopsis thaliana	40-50
25686975-3	2015	Such a modified polysaccharide exhibited excellent ability to condense plasmid pMSCV-GFP-PARK2 into compact and spherical nanoparticles.	Polysaccharides	16-30	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	89-94
25698222-8	2015	Reliable detection and quantitation of these glycans was achieved when the equivalence of 0.005 muL of blood serum was analyzed.	Polysaccharides	45-52	tripartite motif containing 37	Homo sapiens	96-99
26054194-0	2015	[Effect of electroacupuncture intervention combined with polysaccharide of Gastrodia elata Blume on expression of nestin and stem cell factor around the ischemic locus of frontal lobe cortex in local cerebral ischemia rats].	Polysaccharides	57-71	nestin	Rattus norvegicus	114-120
25707740-17	2015	In conclusion, hCG is the major pregnancy glycoprotein hormone, whose maternal concentration and glycan structure change all along pregnancy.	Polysaccharides	97-103	hypertrichosis 2 (generalised, congenital)	Homo sapiens	15-18
25726973-2	2015	Glycans of major envelope glycoprotein 5 (GP5) are proposed as important for virus assembly and entry into permissive cells.	Polysaccharides	0-7	glycoprotein V platelet	Homo sapiens	42-45
25726973-3	2015	Structural characterization of GP5 glycans would facilitate the mechanistic understanding of these processes.	Polysaccharides	35-42	glycoprotein V platelet	Homo sapiens	31-34
25659296-14	2015	Notably, we found that B4GALT3 modified glycans on beta1-integrin, suppressed focal adhesion kinase (FAK) signaling, and enhanced beta1-integrin degradation.	Polysaccharides	40-47	beta-1,4-galactosyltransferase 3	Homo sapiens	23-30
25659296-14	2015	Notably, we found that B4GALT3 modified glycans on beta1-integrin, suppressed focal adhesion kinase (FAK) signaling, and enhanced beta1-integrin degradation.	Polysaccharides	40-47	integrin subunit beta 1	Homo sapiens	51-65
26054194-1	2015	OBJECTIVE: To observe the effect of electroacupuncture (EA), Polysaccharide of Gastrodia elata Blume (PGB), and EA + PGB on the expression of Nestin and stem cell factor (SCF) in the frontal lobe cortex around the ischemic loci of cerebral ischemia (CI) rats, so as to explore its mechanisms underlying improvement of CI.	Polysaccharides	61-75	nestin	Rattus norvegicus	142-148
26281585-4	2015	1--&gt;, 1--&gt;6 and non-reducing terminal linkages existed in polysaccharide P1A, but there are doubling amount of 1--&gt;2 and 1--&gt;4 linkages.	Polysaccharides	64-78	zinc finger protein 185 with LIM domain	Homo sapiens	79-82
26054194-1	2015	OBJECTIVE: To observe the effect of electroacupuncture (EA), Polysaccharide of Gastrodia elata Blume (PGB), and EA + PGB on the expression of Nestin and stem cell factor (SCF) in the frontal lobe cortex around the ischemic loci of cerebral ischemia (CI) rats, so as to explore its mechanisms underlying improvement of CI.	Polysaccharides	61-75	KIT ligand	Rattus norvegicus	171-174
25563949-1	2015	Rhizoma alismatis (the rhizome of Alisma orientalis) polysaccharides (RAP) have been reported to have a variety of important biological activities.	Polysaccharides	53-68	LDL receptor related protein associated protein 1	Homo sapiens	70-73
25563949-7	2015	The results indicated that ultrasound extraction was a very effective method for the extraction of RAP and the polysaccharides could be explored as a potential antioxidant agent for use in medicine or functional food.	Polysaccharides	111-126	LDL receptor related protein associated protein 1	Homo sapiens	99-102
25852737-8	2015	This is largely due to the limited number of functionally characterized enzymes and the lack of studies correlating the specificity of these enzymes with the ability of the strain to degrade and utilize mucin and mucin glycans.	Polysaccharides	219-226	LOC100508689	Homo sapiens	213-218
25564400-3	2015	We carried out a comprehensive functional analysis of the ADAMTS13 cysteine-rich (Cys-rich) domain using engineered glycans, sequence swaps, and single point mutations in this domain.	Polysaccharides	116-123	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	58-66
25564400-5	2015	However, a glycan attached at position 476 appreciably reduced both VWF binding and proteolysis.	Polysaccharides	11-17	von Willebrand factor	Homo sapiens	68-71
25825515-1	2015	Unlike the complex glycans decorating the cell surface, the O-linked beta-N-acetyl glucosamine (O-GlcNAc) modification is a simple intracellular Ser/Thr-linked monosaccharide that is important for disease-relevant signaling and enzyme regulation.	Polysaccharides	19-26	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	96-104
25813863-3	2015	Its counterpart MUC1 is a large polymer rich in glycans containing multiple exchangeable OH protons, which is readily detectable by chemical exchange saturation transfer (CEST) MRI.	Polysaccharides	48-55	mucin 1, cell surface associated	Homo sapiens	16-20
25852737-0	2015	Mucin glycan foraging in the human gut microbiome.	Polysaccharides	6-12	LOC100508689	Homo sapiens	0-5
25852737-9	2015	This review focuses on recent findings unraveling the molecular strategies used by mucin-degrading bacteria to utilize host glycans, adapt to the mucosal environment, and influence human health.	Polysaccharides	124-131	LOC100508689	Homo sapiens	83-88
25780874-1	2015	Chitin (beta-(1-4)-poly-N-acetyl-D-glucosamine) is widely distributed in nature and is the second most abundant polysaccharide after cellulose.	Polysaccharides	112-126	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	8-17
25789487-8	2015	Polysaccharide and MSCs acted additively to increase the expression of anti-inflammatory cytokine (TGF-beta), antiangiogenic cytokine (TSP-1) and decrease those promoting inflammation (TNF-alpha), chemotaxis (MIP-1alpha and MCP-1) and angiogenesis (VEGF and MMP-2).	Polysaccharides	0-14	transforming growth factor, beta 1	Rattus norvegicus	99-107
25789487-8	2015	Polysaccharide and MSCs acted additively to increase the expression of anti-inflammatory cytokine (TGF-beta), antiangiogenic cytokine (TSP-1) and decrease those promoting inflammation (TNF-alpha), chemotaxis (MIP-1alpha and MCP-1) and angiogenesis (VEGF and MMP-2).	Polysaccharides	0-14	thrombospondin 1	Rattus norvegicus	135-140
25789487-8	2015	Polysaccharide and MSCs acted additively to increase the expression of anti-inflammatory cytokine (TGF-beta), antiangiogenic cytokine (TSP-1) and decrease those promoting inflammation (TNF-alpha), chemotaxis (MIP-1alpha and MCP-1) and angiogenesis (VEGF and MMP-2).	Polysaccharides	0-14	tumor necrosis factor	Rattus norvegicus	185-194
25789487-8	2015	Polysaccharide and MSCs acted additively to increase the expression of anti-inflammatory cytokine (TGF-beta), antiangiogenic cytokine (TSP-1) and decrease those promoting inflammation (TNF-alpha), chemotaxis (MIP-1alpha and MCP-1) and angiogenesis (VEGF and MMP-2).	Polysaccharides	0-14	C-C motif chemokine ligand 3	Rattus norvegicus	209-219
25789487-8	2015	Polysaccharide and MSCs acted additively to increase the expression of anti-inflammatory cytokine (TGF-beta), antiangiogenic cytokine (TSP-1) and decrease those promoting inflammation (TNF-alpha), chemotaxis (MIP-1alpha and MCP-1) and angiogenesis (VEGF and MMP-2).	Polysaccharides	0-14	mast cell protease 1-like 1	Rattus norvegicus	224-229
25789487-8	2015	Polysaccharide and MSCs acted additively to increase the expression of anti-inflammatory cytokine (TGF-beta), antiangiogenic cytokine (TSP-1) and decrease those promoting inflammation (TNF-alpha), chemotaxis (MIP-1alpha and MCP-1) and angiogenesis (VEGF and MMP-2).	Polysaccharides	0-14	vascular endothelial growth factor A	Rattus norvegicus	249-253
25789487-8	2015	Polysaccharide and MSCs acted additively to increase the expression of anti-inflammatory cytokine (TGF-beta), antiangiogenic cytokine (TSP-1) and decrease those promoting inflammation (TNF-alpha), chemotaxis (MIP-1alpha and MCP-1) and angiogenesis (VEGF and MMP-2).	Polysaccharides	0-14	matrix metallopeptidase 2	Rattus norvegicus	258-263
25567536-0	2015	Permanent acceptance of mouse cardiac allografts with CD40 siRNA to induce regulatory myeloid cells by use of a novel polysaccharide siRNA delivery system.	Polysaccharides	118-132	CD40 antigen	Mus musculus	54-58
25498624-1	2015	Extraction was optimized of polysaccharides from Gleoestereum incarnatum (GIP).	Polysaccharides	28-43	gastric inhibitory polypeptide	Homo sapiens	74-77
24579562-6	2015	Hair samples were analysed by PCR for the R309H mutation in the glycogen synthase gene (GYS1) responsible for type 1 polysaccharide storage myopathy (PSSM) and the C7360G mutation in the ryanodine receptor 1 (RYR1) gene causing malignant hyperthermia (MH).	Polysaccharides	117-131	glycogen synthase 1	Equus caballus	88-92
25498658-4	2015	The polysaccharides were precipitated with 50% ethanol (EPS-1, IPS-1), 65% ethanol (EPS-2, IPS-2) and 80% ethanol (EPS-3, IPS-3).	Polysaccharides	4-19	inositol-3-phosphate synthase 1	Homo sapiens	63-68
25498712-2	2015	In this study, we investigated the protective effects of a polysaccharide (PS-WNP) from Polygonatum sibiricum against the Abeta(25-35)-induced neurotoxicity in PC12 cells and explored the underlying mechanism.	Polysaccharides	59-73	amyloid beta precursor protein	Rattus norvegicus	122-127
25499591-0	2015	Astragalus polysaccharides repress myocardial lipotoxicity in a PPARalpha-dependent manner in vitro and in vivo in mice.	Polysaccharides	11-26	peroxisome proliferator activated receptor alpha	Mus musculus	64-73
25499591-3	2015	METHODOLOGY/PRINCIPAL FINDINGS: The effects of Astragalus polysaccharides (APS) on PPARalpha target gene expression and protein levels were tested in vitro and in vivo, including in mice with PPARalpha cardiac-restricted overexpression [myosin heavy chain (MHC)-PPARalpha] and in H9c2 embryonic rat cardiomyocytes with or without PPARalpha agonist.	Polysaccharides	58-73	peroxisome proliferator activated receptor alpha	Mus musculus	83-92
25384757-7	2015	Characterization of polysaccharide-treated MDA-MB-231 cell death revealed that induction of apoptosis occurred via the activation of the extrinsic apoptotic caspase-8 gene.	Polysaccharides	20-34	caspase 8	Homo sapiens	157-166
25624454-2	2015	We found that PD-1(-/-) mice, as well as wild-type mice treated with a PD-1 blocking Ab, exhibited significantly increased survival against lethal Streptococcus pneumoniae infection following either priming with low-dose pneumococcal respiratory infection or S. pneumoniae-capsular polysaccharide immunization.	Polysaccharides	282-296	programmed cell death 1	Mus musculus	14-18
25624454-2	2015	We found that PD-1(-/-) mice, as well as wild-type mice treated with a PD-1 blocking Ab, exhibited significantly increased survival against lethal Streptococcus pneumoniae infection following either priming with low-dose pneumococcal respiratory infection or S. pneumoniae-capsular polysaccharide immunization.	Polysaccharides	282-296	programmed cell death 1	Mus musculus	71-75
25505064-4	2015	Galectin-1 is an endogenous carbohydrate-binding protein that binds to specific glycans on NiV-F to reduce endothelial cell fusion, an effect that may reduce pathophysiologic sequelae of NiV infection.	Polysaccharides	80-87	galectin 1	Homo sapiens	0-10
25505064-6	2015	Using live Nipah virus, in the present study, we demonstrate that galectin-1 can enhance NiV attachment to and infection of primary human endothelial cells by bridging glycans on the viral envelope to host cell glycoproteins.	Polysaccharides	168-175	galectin 1	Homo sapiens	66-76
25546301-0	2015	Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262.	Polysaccharides	94-100	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	48-53
25480394-0	2015	Coriolus versicolor mushroom polysaccharides exert immunoregulatory effects on mouse B cells via membrane Ig and TLR-4 to activate the MAPK and NF-kappaB signaling pathways.	Polysaccharides	29-44	toll-like receptor 4	Mus musculus	113-118
25331826-0	2015	Inhibitory function of P-selectin-mediated leukocyte adhesion by the polysaccharides from Sanguisorba officinalis.	Polysaccharides	69-84	selectin P	Homo sapiens	23-33
25331826-3	2015	OBJECTIVE: This study evaluates the effects of polysaccharides (SOPs) from Sanguisorba officinalis on their antagonistic function against P-selectin-mediated leukocyte adhesion.	Polysaccharides	47-62	selectin P	Homo sapiens	138-148
25546301-3	2015	The GlcNAc stem of this glycan is largely buried in a cleft in gp120, suggesting a role in gp120 folding and stability.	Polysaccharides	24-30	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	63-68
25546301-3	2015	The GlcNAc stem of this glycan is largely buried in a cleft in gp120, suggesting a role in gp120 folding and stability.	Polysaccharides	24-30	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	91-96
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Polysaccharides	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
25404118-3	2015	Best studied is beta-1,3-glucan, a glycan that activates complement and is recognized by dectin-1.	Polysaccharides	35-41	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	16-24
25404118-3	2015	Best studied is beta-1,3-glucan, a glycan that activates complement and is recognized by dectin-1.	Polysaccharides	35-41	C-type lectin domain containing 7A	Homo sapiens	89-97
25561735-8	2015	Three of the chitinases also hydrolyzed the beta1-6 bond in LacNAcbeta1-6LacNAcbeta-TMR, an activity that is of potential importance in relation to mammalian glycans.	Polysaccharides	158-165	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	44-51
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Polysaccharides	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25548276-10	2015	We conclude that N-glycosylation of Asn-594 of COX-2 occurs in the ER, leading to anterograde movement of COX-2 to the Golgi where the Asn-594-linked glycan is trimmed prior to retrograde COX-2 transport to the ER for ERAD.	Polysaccharides	150-156	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	106-111
25422905-0	2015	The dimeric crystal structure of the human fertility lipocalin glycodelin reveals a protein scaffold for the presentation of complex glycans.	Polysaccharides	133-140	progestagen associated endometrial protein	Homo sapiens	63-73
25540199-7	2015	These data support a model in which PSA, and possibly other T cell-dependent polysaccharide antigens, elicits a clonal and therefore specific CD4(+) T cell response often characterized by pairing dual-charged CDR3 loop sequences with dual-charged PSA.	Polysaccharides	77-91	aminopeptidase puromycin sensitive	Mus musculus	36-39
25540199-7	2015	These data support a model in which PSA, and possibly other T cell-dependent polysaccharide antigens, elicits a clonal and therefore specific CD4(+) T cell response often characterized by pairing dual-charged CDR3 loop sequences with dual-charged PSA.	Polysaccharides	77-91	CD4 antigen	Mus musculus	142-145
25700108-0	2015	The polysaccharide capsule of Streptococcus pneumonia partially impedes MyD88-mediated immunity during pneumonia in mice.	Polysaccharides	4-18	myeloid differentiation primary response gene 88	Mus musculus	72-77
25586968-1	2015	A comprehensive method for the construction of a high-mannose-type glycan library by systematic chemo-enzymatic trimming of a single Man9-based precursor was developed.	Polysaccharides	67-73	mannosidase alpha class 1A member 1	Homo sapiens	133-137
25708191-0	2015	Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions.	Polysaccharides	116-122	galectin 1	Homo sapiens	31-41
25708191-0	2015	Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions.	Polysaccharides	116-122	galectin 1	Homo sapiens	51-61
25708191-0	2015	Pre-B cell receptor binding to galectin-1 modifies galectin-1/carbohydrate affinity to modulate specific galectin-1/glycan lattice interactions.	Polysaccharides	116-122	galectin 1	Homo sapiens	51-61
25708191-3	2015	Besides binding glycans, GAL1 is also a pre-B cell receptor (pre-BCR) ligand that induces receptor clustering, the first checkpoint of B-cell differentiation.	Polysaccharides	16-23	galectin 1	Homo sapiens	25-29
25708191-5	2015	Here we show that GAL1/pre-BCR interaction modifies GAL1/glycan affinity and particularly inhibits binding to LacNAc containing epitopes.	Polysaccharides	57-63	galectin 1	Homo sapiens	18-22
25708191-5	2015	Here we show that GAL1/pre-BCR interaction modifies GAL1/glycan affinity and particularly inhibits binding to LacNAc containing epitopes.	Polysaccharides	57-63	galectin 1	Homo sapiens	52-56
25708191-6	2015	GAL1/pre-BCR interaction induces local conformational changes in the GAL1 carbohydrate-binding site generating a reduction in GAL1/glycan affinity.	Polysaccharides	131-137	galectin 1	Homo sapiens	0-4
25708191-6	2015	GAL1/pre-BCR interaction induces local conformational changes in the GAL1 carbohydrate-binding site generating a reduction in GAL1/glycan affinity.	Polysaccharides	131-137	galectin 1	Homo sapiens	69-73
25708191-6	2015	GAL1/pre-BCR interaction induces local conformational changes in the GAL1 carbohydrate-binding site generating a reduction in GAL1/glycan affinity.	Polysaccharides	131-137	galectin 1	Homo sapiens	69-73
25708191-7	2015	This fine tuning of GAL1/glycan interactions may be a strategic mechanism for allowing pre-BCR clustering and pre-BII cells departure from their niche.	Polysaccharides	25-31	galectin 1	Homo sapiens	20-24
25708191-8	2015	Altogether, our data suggest a novel mechanism for a cell to modify the equilibrium of the GAL1/glycan lattice involving GAL1/unglycosylated protein interactions.	Polysaccharides	96-102	galectin 1	Homo sapiens	91-95
25708191-8	2015	Altogether, our data suggest a novel mechanism for a cell to modify the equilibrium of the GAL1/glycan lattice involving GAL1/unglycosylated protein interactions.	Polysaccharides	96-102	galectin 1	Homo sapiens	121-125
25575808-2	2015	Experimental evidence showed that human endocan, through its glycan chain, is implicated in various processes of tumor growth.	Polysaccharides	61-67	endothelial cell specific molecule 1	Homo sapiens	40-47
25646460-3	2015	Site-specific glycan analysis provided a detailed view of the glycan microheterogeneity present on the IL9 portion of the recombinant protein.	Polysaccharides	14-20	interleukin 9	Homo sapiens	103-106
25646460-3	2015	Site-specific glycan analysis provided a detailed view of the glycan microheterogeneity present on the IL9 portion of the recombinant protein.	Polysaccharides	62-68	interleukin 9	Homo sapiens	103-106
25499728-0	2015	Suppression of Th2 immune responses by the sulfated polysaccharide from Porphyra haitanensis in tropomyosin-sensitized mice.	Polysaccharides	52-66	heart and neural crest derivatives expressed 2	Mus musculus	15-18
25458285-5	2015	Both polysaccharides were found to stimulate NO production and induce the expression of cytokine mRNAs including IL-1beta, IL-6, IL-10 and TNF-alpha on RAW264.7 cells.	Polysaccharides	5-20	interleukin 1 beta	Mus musculus	113-121
25458285-5	2015	Both polysaccharides were found to stimulate NO production and induce the expression of cytokine mRNAs including IL-1beta, IL-6, IL-10 and TNF-alpha on RAW264.7 cells.	Polysaccharides	5-20	interleukin 6	Mus musculus	123-127
25458285-5	2015	Both polysaccharides were found to stimulate NO production and induce the expression of cytokine mRNAs including IL-1beta, IL-6, IL-10 and TNF-alpha on RAW264.7 cells.	Polysaccharides	5-20	interleukin 10	Mus musculus	129-134
25458285-5	2015	Both polysaccharides were found to stimulate NO production and induce the expression of cytokine mRNAs including IL-1beta, IL-6, IL-10 and TNF-alpha on RAW264.7 cells.	Polysaccharides	5-20	tumor necrosis factor	Mus musculus	139-148
25658763-6	2015	2) Glycosylation of EMMPRIN in monocytes/macrophages led to N-linked-glycans being added to the protein, with the HG form containing complex-type glycans and the less-glycosylated form (LG) the simple type.	Polysaccharides	69-76	basigin (Ok blood group)	Homo sapiens	20-27
25650933-1	2015	Langerin, a trimeric C-type lectin specifically expressed in Langerhans cells, has been reported to be a pathogen receptor through the recognition of glycan motifs by its three carbohydrate recognition domains (CRD).	Polysaccharides	150-156	CD207 molecule	Homo sapiens	0-8
25902030-9	2015	RESULTS: Administration of pectic polysaccharides significantly reduced the severity of DSS-induced colitis as assessed by DAI and histological score, and resulted in down regulation of MPO activity and NF- kappa B p65 expression and subsequent degradation of I kappa B protein, strikingly reduced the production of TNF- a and IL-17.	Polysaccharides	34-49	myeloperoxidase	Mus musculus	186-189
25902030-9	2015	RESULTS: Administration of pectic polysaccharides significantly reduced the severity of DSS-induced colitis as assessed by DAI and histological score, and resulted in down regulation of MPO activity and NF- kappa B p65 expression and subsequent degradation of I kappa B protein, strikingly reduced the production of TNF- a and IL-17.	Polysaccharides	34-49	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	203-214
25902030-9	2015	RESULTS: Administration of pectic polysaccharides significantly reduced the severity of DSS-induced colitis as assessed by DAI and histological score, and resulted in down regulation of MPO activity and NF- kappa B p65 expression and subsequent degradation of I kappa B protein, strikingly reduced the production of TNF- a and IL-17.	Polysaccharides	34-49	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	215-218
25902030-9	2015	RESULTS: Administration of pectic polysaccharides significantly reduced the severity of DSS-induced colitis as assessed by DAI and histological score, and resulted in down regulation of MPO activity and NF- kappa B p65 expression and subsequent degradation of I kappa B protein, strikingly reduced the production of TNF- a and IL-17.	Polysaccharides	34-49	tumor necrosis factor	Mus musculus	316-322
25902030-9	2015	RESULTS: Administration of pectic polysaccharides significantly reduced the severity of DSS-induced colitis as assessed by DAI and histological score, and resulted in down regulation of MPO activity and NF- kappa B p65 expression and subsequent degradation of I kappa B protein, strikingly reduced the production of TNF- a and IL-17.	Polysaccharides	34-49	interleukin 17A	Mus musculus	327-332
25479809-7	2015	An improved polysaccharide/protein (PS/PN) ratio was observed with the increasing Cr(VI) concentration, implying excessive polysaccharide was secreted by microorganisms to support its resistance to the toxicity of Cr(VI).	Polysaccharides	12-26	persephin	Homo sapiens	36-41
25541375-7	2015	TaqMan low density array analysis of A549 cells also confirmed that the induction of apoptosis by the polysaccharide occurred through the TRAIL-DR4/DR5 pathways.	Polysaccharides	102-116	TNF superfamily member 10	Homo sapiens	138-143
25541375-7	2015	TaqMan low density array analysis of A549 cells also confirmed that the induction of apoptosis by the polysaccharide occurred through the TRAIL-DR4/DR5 pathways.	Polysaccharides	102-116	TNF receptor superfamily member 10a	Homo sapiens	144-147
25541375-7	2015	TaqMan low density array analysis of A549 cells also confirmed that the induction of apoptosis by the polysaccharide occurred through the TRAIL-DR4/DR5 pathways.	Polysaccharides	102-116	TNF receptor superfamily member 10b	Homo sapiens	148-151
25545593-1	2015	Previously we showed that conjugation of pneumococcal surface protein A (PspA) to Vi capsular polysaccharide from Salmonella Typhi enhanced the anti-PspA response without the need to add adjuvant.	Polysaccharides	94-108	surfactant associated protein A1	Mus musculus	73-77
25545593-1	2015	Previously we showed that conjugation of pneumococcal surface protein A (PspA) to Vi capsular polysaccharide from Salmonella Typhi enhanced the anti-PspA response without the need to add adjuvant.	Polysaccharides	94-108	surfactant associated protein A1	Mus musculus	149-153
25545593-7	2015	IgG subclass analysis of the anti-Vi response showed a shift from predominantly IgG2a/3 to IgG1 after conjugation to PspA was consistent with other polysaccharide conjugate vaccines.	Polysaccharides	148-162	surfactant associated protein A1	Mus musculus	117-121
25479809-7	2015	An improved polysaccharide/protein (PS/PN) ratio was observed with the increasing Cr(VI) concentration, implying excessive polysaccharide was secreted by microorganisms to support its resistance to the toxicity of Cr(VI).	Polysaccharides	123-137	persephin	Homo sapiens	36-41
25186652-0	2015	miR-124/ATF-6, a novel lifespan extension pathway of Astragalus polysaccharide in Caenorhabditis elegans.	Polysaccharides	64-78	mir-124	Caenorhabditis elegans	0-13
25497797-12	2015	All the identified glycosylated CMP isoforms had lower reaction rates of release compared with that of nonglycosylated CMP, thus glycan modifications seemed to negatively influence the reaction rate of chymosin-induced hydrolysis of kappa-CN.	Polysaccharides	129-135	chymosin	Bos taurus	202-210
25497797-12	2015	All the identified glycosylated CMP isoforms had lower reaction rates of release compared with that of nonglycosylated CMP, thus glycan modifications seemed to negatively influence the reaction rate of chymosin-induced hydrolysis of kappa-CN.	Polysaccharides	129-135	casein kappa	Bos taurus	233-241
25453468-3	2015	CXCL8 is maintained in an active state by this glycan interaction thus increasing infiltration of immune cells such as neutrophils into the lungs.	Polysaccharides	47-53	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
25155442-12	2015	PRX-102 has a relatively simple glycosylation pattern, characteristic to plants, having mainly tri-mannose structures with the addition of either alpha(1-3)-linked fucose or beta(1-2)-linked xylose, or both, in addition to various high mannose structures, while agalsidase beta has a mixture of sialylated glycans in addition to high mannose structures.	Polysaccharides	306-313	periaxin	Homo sapiens	0-3
26137696-0	2015	[Effect of MDG-1, a polysaccharide from Ophiopogon japonicas, on diversity of lactobacillus in diet-induced obese mice].	Polysaccharides	20-34	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	11-16
25617778-7	2015	Conversely, when Kkv and Exp/Reb are co-expressed in the ectoderm, they promote chitin deposition, even in tissues normally devoid of this polysaccharide.	Polysaccharides	139-153	krotzkopf verkehrt	Drosophila melanogaster	17-20
25617778-7	2015	Conversely, when Kkv and Exp/Reb are co-expressed in the ectoderm, they promote chitin deposition, even in tissues normally devoid of this polysaccharide.	Polysaccharides	139-153	expansion	Drosophila melanogaster	25-28
25617778-7	2015	Conversely, when Kkv and Exp/Reb are co-expressed in the ectoderm, they promote chitin deposition, even in tissues normally devoid of this polysaccharide.	Polysaccharides	139-153	rebuf	Drosophila melanogaster	29-32
25498912-3	2015	We evaluated the role of 3 alpha(2,3)sialyltransferases, ST3Gal-3, -4, and -6, which act on the type II N-Acetyllactosamine structure (Galbeta1,4GlcNAc) to create sialyl Lewis-X (sLe(X)) and related sialofucosylated glycans on human leukocytes of myeloid lineage.	Polysaccharides	216-223	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	57-77
25525995-1	2015	A novel polysaccharide, here named DP1, was isolated from the fruiting body of Dictyophora indusiata using a water extraction method.	Polysaccharides	8-22	transcription factor Dp 1	Mus musculus	35-38
25601073-7	2015	Our results identified key antigenic determinants of LPS core glycan and, hence, may aid the design of a broadly protective immunization against N. meningitidis.	Polysaccharides	62-68	toll-like receptor 4	Mus musculus	53-56
25536026-1	2015	A new acidic polysaccharide (PLP) was isolated and characterized from Plantago asiatic L. seeds by hot alkali extraction and chromatographic purification using DEAE cellulose and Sephacryl S-400 columns.	Polysaccharides	13-27	proteolipid protein 1	Homo sapiens	29-32
25561553-0	2015	Structure of FcgammaRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding.	Polysaccharides	68-74	Fc gamma receptor Ia	Homo sapiens	13-22
25561553-8	2015	Ala and Glu mutations of the FG loop KHR residues showed significant contributions of His-174 and Arg-175 to antibody binding, and the loss of the FG loop-glycan interaction resulted in an ~ 20- to 30-fold decrease in FcgammaRI affinity to all three subclasses of IgGs.	Polysaccharides	155-161	Fc gamma receptor Ia	Homo sapiens	218-227
25561553-9	2015	Furthermore, deglycosylation of IgG1 resulted in a 40-fold loss in FcgammaRI binding, demonstrating involvement of the receptor FG loop in glycan recognition.	Polysaccharides	139-145	Fc gamma receptor Ia	Homo sapiens	67-76
25561553-10	2015	These results highlight a unique glycan recognition in FcgammaRI function and open potential therapeutic avenues based on antibody glycan engineering or small molecular glycan mimics to target FcgammaRI for certain autoimmune diseases.	Polysaccharides	33-39	Fc gamma receptor Ia	Homo sapiens	55-64
25561553-10	2015	These results highlight a unique glycan recognition in FcgammaRI function and open potential therapeutic avenues based on antibody glycan engineering or small molecular glycan mimics to target FcgammaRI for certain autoimmune diseases.	Polysaccharides	33-39	Fc gamma receptor Ia	Homo sapiens	193-202
25561553-10	2015	These results highlight a unique glycan recognition in FcgammaRI function and open potential therapeutic avenues based on antibody glycan engineering or small molecular glycan mimics to target FcgammaRI for certain autoimmune diseases.	Polysaccharides	131-137	Fc gamma receptor Ia	Homo sapiens	55-64
25561553-10	2015	These results highlight a unique glycan recognition in FcgammaRI function and open potential therapeutic avenues based on antibody glycan engineering or small molecular glycan mimics to target FcgammaRI for certain autoimmune diseases.	Polysaccharides	131-137	Fc gamma receptor Ia	Homo sapiens	55-64
25591783-6	2015	Moreover, alkaline phosphatase activity, calcium deposition and acidic polysaccharide staining were reduced after BMP2-induced differentiation.	Polysaccharides	71-85	bone morphogenetic protein 2	Homo sapiens	114-118
25078944-0	2015	Submerged cultivation of Ganoderma lucidum and the effects of its polysaccharides on the production of human cytokines TNF-alpha, IL-12, IFN-gamma, IL-2, IL-4, IL-10 and IL-17.	Polysaccharides	66-81	tumor necrosis factor	Homo sapiens	119-128
25078944-5	2015	Human peripheral blood mononuclear cells (PBMC) were activated in vitro with polysaccharide fractions, in order to induce innate inflammatory cytokines: tumor necrosis factor alpha (TNF-alpha), interleukin (IL) 12 and interferon gamma (IFN-gamma).	Polysaccharides	77-91	tumor necrosis factor	Homo sapiens	153-180
25078944-8	2015	Fungal cell-wall polysaccharides were stronger innate inflammatory cytokines inducers, while extracellular polysaccharides demonstrated a higher capacity to modulate cytokine responses of IONO+PMA induced production of IL-17.	Polysaccharides	107-122	interleukin 17A	Homo sapiens	219-224
25078944-11	2015	All of the polysaccharide fractions tested induced IL-17 production at different concentration levels.	Polysaccharides	11-25	interleukin 17A	Homo sapiens	51-56
25445294-8	2015	The model of Fis was then docked onto the corresponding promoter regions of the gene encoding the capsular polysaccharide.	Polysaccharides	107-121	DNA-binding transcriptional regulator Fis	Pasteurella multocida	13-16
25212389-1	2015	The mucin MUC1 is a glycoprotein involved in fundamental biological processes, which can be found over-expressed and with a distinctly altered glycan pattern on epithelial tumor cells; thus it is a promising target structure in the quest for effective carbohydrate-based cancer vaccines and immunotherapeutics.	Polysaccharides	143-149	mucin 1, cell surface associated	Homo sapiens	10-14
25437919-6	2015	We use a lectin capture strategy coupled to nano-ESI-RPLC-MS/MS to isolate and identify the membrane glycoproteins and unique glycan structures associated with GnT-III amplification in human ovarian cancer tissues.	Polysaccharides	126-132	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	160-167
25305479-0	2015	Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARgamma factor and the NADPH oxidase/ROS-NF-kappaB signal pathway.	Polysaccharides	30-45	peroxisome proliferator activated receptor gamma	Homo sapiens	100-109
25305479-0	2015	Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARgamma factor and the NADPH oxidase/ROS-NF-kappaB signal pathway.	Polysaccharides	30-45	nuclear factor kappa B subunit 1	Homo sapiens	143-152
25305479-1	2015	AIM: Polysaccharides were extracted from Rhizoma Dioscoreae Nipponicae to investigate whether Rhizoma Dioscoreae Nipponicae polysaccharides (RDNP) can act as an antioxidant and PPARgamma agonist to protect HUVECs from H2O2-induced injury.	Polysaccharides	124-139	peroxisome proliferator activated receptor gamma	Homo sapiens	177-186
26098720-3	2015	These changes occur principally in beta1,4-N-acetylglucosaminyltransferase III (GnT-III) that catalyzes the synthesis of glycans with bisected N-acetylglucosamine (GlcNAc) and beta1,6-N-acetylglucosaminyltransferase V (GnT-V) that is involved in forming beta1,6-branched antenna in complex-type glycans.	Polysaccharides	121-128	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	80-87
26098720-3	2015	These changes occur principally in beta1,4-N-acetylglucosaminyltransferase III (GnT-III) that catalyzes the synthesis of glycans with bisected N-acetylglucosamine (GlcNAc) and beta1,6-N-acetylglucosaminyltransferase V (GnT-V) that is involved in forming beta1,6-branched antenna in complex-type glycans.	Polysaccharides	121-128	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B	Homo sapiens	176-217
26098720-3	2015	These changes occur principally in beta1,4-N-acetylglucosaminyltransferase III (GnT-III) that catalyzes the synthesis of glycans with bisected N-acetylglucosamine (GlcNAc) and beta1,6-N-acetylglucosaminyltransferase V (GnT-V) that is involved in forming beta1,6-branched antenna in complex-type glycans.	Polysaccharides	121-128	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	219-224
26098720-3	2015	These changes occur principally in beta1,4-N-acetylglucosaminyltransferase III (GnT-III) that catalyzes the synthesis of glycans with bisected N-acetylglucosamine (GlcNAc) and beta1,6-N-acetylglucosaminyltransferase V (GnT-V) that is involved in forming beta1,6-branched antenna in complex-type glycans.	Polysaccharides	295-302	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	80-87
26098720-3	2015	These changes occur principally in beta1,4-N-acetylglucosaminyltransferase III (GnT-III) that catalyzes the synthesis of glycans with bisected N-acetylglucosamine (GlcNAc) and beta1,6-N-acetylglucosaminyltransferase V (GnT-V) that is involved in forming beta1,6-branched antenna in complex-type glycans.	Polysaccharides	295-302	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B	Homo sapiens	176-217
26098720-3	2015	These changes occur principally in beta1,4-N-acetylglucosaminyltransferase III (GnT-III) that catalyzes the synthesis of glycans with bisected N-acetylglucosamine (GlcNAc) and beta1,6-N-acetylglucosaminyltransferase V (GnT-V) that is involved in forming beta1,6-branched antenna in complex-type glycans.	Polysaccharides	295-302	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	219-224
26098720-6	2015	The higher beta1,6-branching of glycans in UM may contribute to their higher potential to migrate on fibronectin and weaker binding to main extracellular matrix proteins, observed in our previous studies.	Polysaccharides	32-39	fibronectin 1	Homo sapiens	101-112
25965496-3	2015	Structural analyses has revealed that this polysaccharide with a molecular mass of 8430,000g/mol was mainly composed of a galactan backbone of a (1   4) linked beta-d-Galp residues probably substituted at position 3 by L-arabinofuranosyl residues.	Polysaccharides	43-57	galanin like peptide	Homo sapiens	167-171
25727146-1	2015	Mucin-type O-glycans are a class of glycans initiated with N-acetylgalactosamine (GalNAc) alpha-linked primarily to Ser/Thr residues within glycoproteins and often extended or branched by sugars or saccharides.	Polysaccharides	13-20	LOC100508689	Homo sapiens	0-5
25727153-4	2015	The single site of N-glycosylation on PSA has been the target of multiple glycan characterization studies.	Polysaccharides	74-80	kallikrein related peptidase 3	Homo sapiens	38-41
25315246-0	2015	Functional improvements in beta-lactoglobulin by conjugating with soybean soluble polysaccharide.	Polysaccharides	82-96	beta-lactoglobulin	Bos taurus	27-45
25415237-1	2015	This study aimed to investigate the effects of polysaccharide from Angelica and Astragalus (AAP) on carbon tetrachloride (CCl4) induced liver damage in mice.	Polysaccharides	47-61	chemokine (C-C motif) ligand 4	Mus musculus	122-126
26599414-1	2015	This study aims to evaluate for the first time the effects of Cymodocea nodosa sulphated polysaccharide (CNSP) on lipase activity in vitro and in vivo to high fat diet (HFD)-rats on body weight, lipid profile and liver-kidney functions.	Polysaccharides	89-103	lipase G, endothelial type	Rattus norvegicus	114-120
26730147-2	2015	Pancreatic alpha-amylase and alpha-glucosidases are responsible for the conversion of polysaccharides into glucose that enters in the blood stream.	Polysaccharides	86-101	amylase alpha 2A	Homo sapiens	0-24
25868343-2	2015	The effect of different concentrations of the polysaccharide on production of TNF-alpha, IL-1beta and IL-6 was studied.	Polysaccharides	46-60	tumor necrosis factor	Homo sapiens	78-87
25868343-2	2015	The effect of different concentrations of the polysaccharide on production of TNF-alpha, IL-1beta and IL-6 was studied.	Polysaccharides	46-60	interleukin 1 beta	Homo sapiens	89-97
25868343-2	2015	The effect of different concentrations of the polysaccharide on production of TNF-alpha, IL-1beta and IL-6 was studied.	Polysaccharides	46-60	interleukin 6	Homo sapiens	102-106
25759815-1	2015	Chitosan is a polysaccharide composed of randomly distributed chains of beta-(1-4) D-glucosamine and N-acetyl-D-glucosamine.	Polysaccharides	14-28	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	72-81
25494612-2	2015	Recent findings from our studies indicate that basal autophagy is required for the efficient lysosomal catabolism of sialyloligosaccharides, and that the downregulation of sialin, a lysosomal transporter of sialic acids can cause a significant delay in the cytosolic accumulation of such glycans.	Polysaccharides	288-295	solute carrier family 17 member 5	Homo sapiens	172-178
26357858-13	2015	New findings concerning the molecular/cellular mechanism involved in the pathogenesis of IgA nephropathy suggest the possible therapeutical interference with the generation of nephritogenic immune complexes by a selective blocking of the IgA1 molecules with altered glycan structures using monovalent reagents.	Polysaccharides	266-272	immunoglobulin heavy constant alpha 1	Homo sapiens	238-242
25750456-3	2015	Mass Spectrometry (MS) has evolved as one of the most powerful tools in glycomics and glycoproteomics and in combination with porous graphitized carbon-liquid chromatography (PGC-LC) it is a versatile and sensitive technique for the analysis of glycans and to some extent also glycopeptides.	Polysaccharides	245-252	progastricsin	Homo sapiens	175-178
25750456-4	2015	PGC-LC-ESI-MS analysis is characterized by a high isomer separation power enabling a specific glycan compound analysis on the level of individual structures.	Polysaccharides	94-100	progastricsin	Homo sapiens	0-3
25174881-6	2015	This test assessed the binding affinity of HGF to sulfated glycans in fecal samples and determined fecal pH as an indicator of illness severity.	Polysaccharides	59-66	hepatocyte growth factor	Homo sapiens	43-46
25174881-15	2015	Test-strip determination of the binding affinity of fecal HGF to sulfated glycan was a rapid, equipment-free way to assess patients with diarrhea and to guide the diagnostic and therapeutic approaches on admission.	Polysaccharides	74-80	hepatocyte growth factor	Homo sapiens	58-61
26328315-0	2015	Delivery of Transferrin-Conjugated Polysaccharide Nanoparticles in 9L Gliosacoma Cells.	Polysaccharides	35-49	transferrin	Homo sapiens	12-23
25431018-4	2015	Moreover, polyphenols, polysaccharides, or caffeine can improve blood lipid and antioxidant levels, and effectively reduce rat serum leptin levels, inhibit the absorption of fatty acids, and markedly reduce the expression levels of the IL-6 and TNF-alpha gene.	Polysaccharides	23-38	leptin	Rattus norvegicus	133-139
25431018-4	2015	Moreover, polyphenols, polysaccharides, or caffeine can improve blood lipid and antioxidant levels, and effectively reduce rat serum leptin levels, inhibit the absorption of fatty acids, and markedly reduce the expression levels of the IL-6 and TNF-alpha gene.	Polysaccharides	23-38	interleukin 6	Rattus norvegicus	236-240
25431018-4	2015	Moreover, polyphenols, polysaccharides, or caffeine can improve blood lipid and antioxidant levels, and effectively reduce rat serum leptin levels, inhibit the absorption of fatty acids, and markedly reduce the expression levels of the IL-6 and TNF-alpha gene.	Polysaccharides	23-38	tumor necrosis factor	Rattus norvegicus	245-254
25431018-5	2015	Furthermore, it was shown that polysaccharides and polyphenols were synergistic in reduction of serum leptin levels and in anti-inflammatory activity.	Polysaccharides	31-46	leptin	Rattus norvegicus	102-108
24603981-1	2015	BACKGROUND: Recently, a novel marker, hyperglycosylated Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA(+)-M2BP), was developed for liver fibrosis using the glycan "sugar chain"-based immunoassay; however, the feasibility of WFA(+)-M2BP for assessing liver fibrosis has not been proven with clinical samples of hepatitis.	Polysaccharides	176-182	galectin 3 binding protein	Homo sapiens	126-130
24603981-6	2015	CONCLUSIONS: Serum WFA(+)-M2BP values based on a glycan-based immunoassay is an accurate, reliable, and reproducible method for the assessment of liver fibrosis.	Polysaccharides	49-55	galectin 3 binding protein	Homo sapiens	26-30
25213400-6	2015	Here we review and analyze all published data on the physicochemical structure of the glycans linked to P0, PMP22, MOG, and MAG.	Polysaccharides	86-93	peripheral myelin protein 22	Homo sapiens	108-113
25213400-6	2015	Here we review and analyze all published data on the physicochemical structure of the glycans linked to P0, PMP22, MOG, and MAG.	Polysaccharides	86-93	myelin oligodendrocyte glycoprotein	Homo sapiens	115-118
25213400-7	2015	Most data concern bovine P0, whose glycan moieties have an MW ranging from 1,294.56 Da (GP3) to 2,279.94 Da (GP5).	Polysaccharides	35-41	glycoprotein V platelet	Bos taurus	109-112
25348600-6	2015	Since DYT1 positively regulates 33 genes involved in cell-wall modification (such as, TDF1, AMS, MYB103, MS1, MS2) that can catalyze the breakdown of polysaccharides to facilitate anther dehiscence, the consistent decrease in the transcription of these genes after IM exposure should hamper anther opening as observed under scanning electron microscopy.	Polysaccharides	150-165	basic helix-loop-helix (bHLH) DNA-binding superfamily protein	Arabidopsis thaliana	6-10
25348600-6	2015	Since DYT1 positively regulates 33 genes involved in cell-wall modification (such as, TDF1, AMS, MYB103, MS1, MS2) that can catalyze the breakdown of polysaccharides to facilitate anther dehiscence, the consistent decrease in the transcription of these genes after IM exposure should hamper anther opening as observed under scanning electron microscopy.	Polysaccharides	150-165	Duplicated homeodomain-like superfamily protein	Arabidopsis thaliana	86-90
25348600-6	2015	Since DYT1 positively regulates 33 genes involved in cell-wall modification (such as, TDF1, AMS, MYB103, MS1, MS2) that can catalyze the breakdown of polysaccharides to facilitate anther dehiscence, the consistent decrease in the transcription of these genes after IM exposure should hamper anther opening as observed under scanning electron microscopy.	Polysaccharides	150-165	myb domain protein 103	Arabidopsis thaliana	97-103
25348600-6	2015	Since DYT1 positively regulates 33 genes involved in cell-wall modification (such as, TDF1, AMS, MYB103, MS1, MS2) that can catalyze the breakdown of polysaccharides to facilitate anther dehiscence, the consistent decrease in the transcription of these genes after IM exposure should hamper anther opening as observed under scanning electron microscopy.	Polysaccharides	150-165	RING/FYVE/PHD zinc finger superfamily protein	Arabidopsis thaliana	105-108
25348600-6	2015	Since DYT1 positively regulates 33 genes involved in cell-wall modification (such as, TDF1, AMS, MYB103, MS1, MS2) that can catalyze the breakdown of polysaccharides to facilitate anther dehiscence, the consistent decrease in the transcription of these genes after IM exposure should hamper anther opening as observed under scanning electron microscopy.	Polysaccharides	150-165	methionine synthase 2	Arabidopsis thaliana	110-113
25187161-6	2015	The glycan antennae in TCRdelta(-/-) colon and small intestine showed altered structural diversity compared with WT mice.	Polysaccharides	4-10	T cell receptor delta chain	Mus musculus	23-31
25450832-7	2015	Furthermore, molecular signaling studies showed a high upregulation in p-p38 and p-MEK molecules in particulate polysaccharide treated RAW264.7 cells suggesting a cellular downstream mechanistic regulation behind the immunostimulative response.	Polysaccharides	112-126	mitogen-activated protein kinase 14	Mus musculus	73-76
25213400-9	2015	The most charged glycan is MS2 containing three sulfate groups and one glucuronic acid; whereas the least charged one is the BA2 residue.	Polysaccharides	17-23	MS2	Homo sapiens	27-30
26155753-0	2015	The luteotrophic function of galectin-1 by binding to the glycans on vascular endothelial growth factor receptor-2 in bovine luteal cells.	Polysaccharides	58-65	galectin 1	Bos taurus	29-39
26155753-0	2015	The luteotrophic function of galectin-1 by binding to the glycans on vascular endothelial growth factor receptor-2 in bovine luteal cells.	Polysaccharides	58-65	kinase insert domain receptor	Bos taurus	69-114
26155753-8	2015	VEGFR-2 protein, like galectin-1, is also highly expressed in the mid CL, and it was modified by multi-antennary glycans, which can be recognized by galectin-1.	Polysaccharides	113-120	kinase insert domain receptor	Bos taurus	0-7
26155753-8	2015	VEGFR-2 protein, like galectin-1, is also highly expressed in the mid CL, and it was modified by multi-antennary glycans, which can be recognized by galectin-1.	Polysaccharides	113-120	galectin 1	Bos taurus	22-32
26155753-8	2015	VEGFR-2 protein, like galectin-1, is also highly expressed in the mid CL, and it was modified by multi-antennary glycans, which can be recognized by galectin-1.	Polysaccharides	113-120	galectin 1	Bos taurus	149-159
25953541-2	2015	In this work, we attempted to develop a facile "enzyme-free" fluoroimmunoassay based on the novel nanoconjugates composed of CdS quantum dots (QDs) as the fluorescent inorganic core and an antibody-modified polysaccharide as the organic shell, modeling their possible application for the in vitro diagnosis of non-Hodgkin lymphoma (NHL) cancer.	Polysaccharides	207-221	CDP-diacylglycerol synthase 1	Homo sapiens	125-128
25524207-6	2015	Moreover, proline mutations in the upper hinge region and removal of the Fc glycan enhanced the FVIII-mimetic activity, suggesting that flexibility of the upper hinge region and the Fc portion structure are important for the FVIII-mimetic activity.	Polysaccharides	76-82	coagulation factor VIII	Homo sapiens	96-101
25524207-6	2015	Moreover, proline mutations in the upper hinge region and removal of the Fc glycan enhanced the FVIII-mimetic activity, suggesting that flexibility of the upper hinge region and the Fc portion structure are important for the FVIII-mimetic activity.	Polysaccharides	76-82	coagulation factor VIII	Homo sapiens	225-230
25250523-3	2015	It has been recently shown that mechanically well-defined injectable polysaccharide hydrogels can be engineered by switching their secondary structure from an alpha-helix to a beta-sheet.	Polysaccharides	69-83	amyloid beta precursor protein	Homo sapiens	174-180
26082223-3	2015	Here, we describe GlcNAcase suppression strategy using RNA interference (RNAi) to avoid the formation of paucimannosidic glycans in insect S2 cells.	Polysaccharides	121-128	O-GlcNAcase	Drosophila melanogaster	18-27
26067753-4	2015	Mass spectrometry-based glycan analyses revealed efficient processing of Fab glycans toward envisaged structures.	Polysaccharides	24-30	FA complementation group B	Homo sapiens	73-76
26067753-4	2015	Mass spectrometry-based glycan analyses revealed efficient processing of Fab glycans toward envisaged structures.	Polysaccharides	77-84	FA complementation group B	Homo sapiens	73-76
25753701-0	2015	NMR chemical shift prediction of glycans: application of the computer program CASPER in structural analysis.	Polysaccharides	33-40	CASP8 and FADD like apoptosis regulator	Homo sapiens	78-84
25378534-8	2015	Removal of antibody glycans increased the flexibility of the FcRn binding site in the Fc region.	Polysaccharides	20-27	Fc gamma receptor and transporter	Homo sapiens	61-65
25753701-3	2015	The computerized approach based on the CASPER program can facilitate rapid structural determination of glycans with little user intervention, which results in the most probable primary structure of the investigated carbohydrate material.	Polysaccharides	103-110	CASP8 and FADD like apoptosis regulator	Homo sapiens	39-45
25253131-7	2015	We provide one example where a pull-down assay with all the GST-tagged canine galectins reveals that the C-terminal carbohydrate recognition domain of galectin-9 (Gal-9C) specifically recognizes the glycan-dependent apical targeting signal from the glycoprotein MUC1.	Polysaccharides	199-205	galectin-9	Canis lupus familiaris	151-161
25253131-7	2015	We provide one example where a pull-down assay with all the GST-tagged canine galectins reveals that the C-terminal carbohydrate recognition domain of galectin-9 (Gal-9C) specifically recognizes the glycan-dependent apical targeting signal from the glycoprotein MUC1.	Polysaccharides	199-205	mucin 1, cell surface associated	Canis lupus familiaris	262-266
25253137-3	2015	To overcome limitations in the analysis of GBP-glycan interactions, recent studies utilized glycan microarray platforms containing hundreds of structurally defined glycans.	Polysaccharides	47-53	galectin 1	Homo sapiens	43-46
25253137-3	2015	To overcome limitations in the analysis of GBP-glycan interactions, recent studies utilized glycan microarray platforms containing hundreds of structurally defined glycans.	Polysaccharides	92-98	galectin 1	Homo sapiens	43-46
25253137-4	2015	These studies not only provided important information regarding GBP-glycan interactions, but have also resulted in significant insight into the binding specificity and biological activity of the galectin family.	Polysaccharides	68-74	galectin 1	Homo sapiens	64-67
26156539-5	2015	Sulfated polysaccharides/glycopeptides and flavonoids may have synergistic effects with targeted anti-angiogenic drugs mainly targeting VEGF pathway by inhibiting bFGF and HIF-1alpha pathway, respectively.	Polysaccharides	9-24	vascular endothelial growth factor A	Homo sapiens	136-140
26156539-5	2015	Sulfated polysaccharides/glycopeptides and flavonoids may have synergistic effects with targeted anti-angiogenic drugs mainly targeting VEGF pathway by inhibiting bFGF and HIF-1alpha pathway, respectively.	Polysaccharides	9-24	fibroblast growth factor 2	Homo sapiens	163-167
26156539-5	2015	Sulfated polysaccharides/glycopeptides and flavonoids may have synergistic effects with targeted anti-angiogenic drugs mainly targeting VEGF pathway by inhibiting bFGF and HIF-1alpha pathway, respectively.	Polysaccharides	9-24	hypoxia inducible factor 1 subunit alpha	Homo sapiens	172-182
25379652-3	2015	Recently, several marine polysaccharides such alginate, porphyran, fucoidan, and chitin and its derivatives have been evidenced as downregulators of allergic responses due to enhancement of innate immune system, alteration of Th1/Th2 balance forward to Th1 cells, inhibition of IgE production, and suppression of mast cell degranulation.	Polysaccharides	25-40	negative elongation factor complex member C/D	Homo sapiens	226-229
25379652-3	2015	Recently, several marine polysaccharides such alginate, porphyran, fucoidan, and chitin and its derivatives have been evidenced as downregulators of allergic responses due to enhancement of innate immune system, alteration of Th1/Th2 balance forward to Th1 cells, inhibition of IgE production, and suppression of mast cell degranulation.	Polysaccharides	25-40	negative elongation factor complex member C/D	Homo sapiens	253-256
25412264-2	2015	The aim of this study was to evaluate the chemopreventive efficacy of apple polysaccharide extract (AP) in inhibiting NF-kappaB-mediated inflammation pathways in CRC.	Polysaccharides	76-90	nuclear factor kappa B subunit 1	Homo sapiens	118-127
25402769-1	2015	The serum protein complement factor H (FH) ensures downregulation of the complement alternative pathway, a branch of innate immunity, upon interaction with specific glycans on host cell surfaces.	Polysaccharides	165-172	complement factor H	Homo sapiens	29-37
25402769-1	2015	The serum protein complement factor H (FH) ensures downregulation of the complement alternative pathway, a branch of innate immunity, upon interaction with specific glycans on host cell surfaces.	Polysaccharides	165-172	complement factor H	Homo sapiens	39-41
25402769-2	2015	Using ligand-based NMR, we screened a comprehensive set of sialylated glycans for binding to FH and solved the crystal structure of a ternary complex formed by the two C-terminal domains of FH, a sialylated trisaccharide and the complement C3b thioester-containing domain.	Polysaccharides	70-77	complement factor H	Homo sapiens	93-95
25402769-2	2015	Using ligand-based NMR, we screened a comprehensive set of sialylated glycans for binding to FH and solved the crystal structure of a ternary complex formed by the two C-terminal domains of FH, a sialylated trisaccharide and the complement C3b thioester-containing domain.	Polysaccharides	70-77	complement factor H	Homo sapiens	190-192
26080540-3	2015	In recent year, a number of investigators reported medicinal fungal polysaccharides showed good anti-diabetes and hypoglycemic activity, and their acting mechanisms involved in glycometabolism and beta cell function, e. g. promoting glycogen synthesis, promoting glycolysis, inhibiting the activity of alpha-glucosidase, promoting insulin secretion, increasing insulin sensitivity, enhancing antioxidation.	Polysaccharides	68-83	sucrase-isomaltase	Homo sapiens	302-319
26080540-3	2015	In recent year, a number of investigators reported medicinal fungal polysaccharides showed good anti-diabetes and hypoglycemic activity, and their acting mechanisms involved in glycometabolism and beta cell function, e. g. promoting glycogen synthesis, promoting glycolysis, inhibiting the activity of alpha-glucosidase, promoting insulin secretion, increasing insulin sensitivity, enhancing antioxidation.	Polysaccharides	68-83	insulin	Homo sapiens	331-338
27110600-0	2014	Tools to MSn Sequence and Document the Structures of Glycan Epitopes.	Polysaccharides	53-59	moesin	Homo sapiens	9-12
25535040-6	2014	Furthermore, we identified that polysaccharides modulated inflammation and apoptosis partly through inhibition of NF-kappaB and HIF-1alpha expressions, respectively.	Polysaccharides	32-47	hypoxia inducible factor 1, alpha subunit	Mus musculus	128-138
27110600-1	2014	Sequential disassembly (MSn) has been applied to fully characterise and document native samples containing glycan epitopes with their synthetic analogues.	Polysaccharides	107-113	moesin	Homo sapiens	24-27
25403811-1	2014	The anti-HIV lectin actinohivin (AH) specifically interacts with HMTG (high-mannose-type glycan), which is attached to the glycoprotein gp120 of HIV-1 in a process in which the three branched mannotriose chains (D1, D2, and D3) of HMTG exhibit different binding affinities, it being estimated that that of D1 is the strongest, that of D3 is weaker, and that of D2 is undetectable.	Polysaccharides	89-95	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	136-141
25038691-1	2014	The bovine milk glycoprotein bovine lactoferrin (bLF) has a variety of biological activities related to its constituent glycans.	Polysaccharides	120-127	lactotransferrin	Bos taurus	36-47
25263880-0	2014	MDG-1, a polysaccharide from Ophiopogon japonicus, prevents high fat diet-induced obesity and increases energy expenditure in mice.	Polysaccharides	9-23	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	0-5
25263880-1	2014	MDG-1, a water-soluble polysaccharide extracted from Ophiopogon japonicus, has potent hypoglycemic and weight control effects.	Polysaccharides	23-37	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	0-5
25263908-2	2014	HA, a naturally occurring polysaccharide, which specifically binds to the CD44 receptor, was coated on a cationic lipid core through electrostatic interaction.	Polysaccharides	26-40	CD44 antigen	Mus musculus	74-78
25354954-0	2014	Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.	Polysaccharides	12-18	signal peptide peptidase like 3	Homo sapiens	40-71
25354954-0	2014	Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation.	Polysaccharides	12-18	signal peptide peptidase like 3	Homo sapiens	73-78
25265424-5	2014	MSn analysis of permethylated detached glycans confirms the presence of LeY glycoforms on haptoglobin, which cannot be detected in hemopexin or complement factor H; all three proteins carry Lewis and H epitopes.	Polysaccharides	39-46	moesin	Homo sapiens	0-3
25331944-7	2014	We interpret the available evidence as suggesting that COBRA facilitates cellulose crystallization from the emerging beta1-4-glucan chains by acting as a "polysaccharide chaperone."	Polysaccharides	155-169	COBRA-like extracellular glycosyl-phosphatidyl inositol-anchored protein family	Arabidopsis thaliana	55-60
25331944-7	2014	We interpret the available evidence as suggesting that COBRA facilitates cellulose crystallization from the emerging beta1-4-glucan chains by acting as a "polysaccharide chaperone."	Polysaccharides	155-169	beta-1,2-xylosyltransferase	Arabidopsis thaliana	117-124
25479762-4	2014	Tumor-specific changes in the glycans have also been observed, suggesting that the N-glycans on hGGT1 would be an important biomarker for detecting tumors and monitoring their progression during treatment.	Polysaccharides	30-37	gamma-glutamyltransferase 1	Homo sapiens	96-101
25265424-5	2014	MSn analysis of permethylated detached glycans confirms the presence of LeY glycoforms on haptoglobin, which cannot be detected in hemopexin or complement factor H; all three proteins carry Lewis and H epitopes.	Polysaccharides	39-46	haptoglobin	Homo sapiens	90-101
25265424-6	2014	Core fucosylation is detectable in only trace amounts in haptoglobin but with confidence on hemopexin and complement factor H, where core fucosylation of the bi-antennary glycans on select glycopeptides reaches 15-20% intensity.	Polysaccharides	171-178	complement factor H	Homo sapiens	106-125
25327667-5	2014	PSA has a single glycosylation site at Asn69, with glycans constituting approximately 8% of the protein by weight.	Polysaccharides	51-58	kallikrein related peptidase 3	Homo sapiens	0-3
25049238-3	2014	Based on the crystallographic structure of the N-Epa1p domain and the role of the variable loop CBL2 in glycan binding, saturation mutagenesis on some residues of the CBL2 loop was used to increase the binding affinity of N-Epa1p for fibronectin, which was selected as a model of a human glycoprotein.	Polysaccharides	104-110	Cbl proto-oncogene	Homo sapiens	167-171
25458834-4	2014	To elucidate the structural basis of the glycan-dependent and independent interactions, we performed comparative crystallographic studies of podoplanin and rhodocytin in complex with CLEC-2.	Polysaccharides	41-47	C-type lectin domain family 1 member B	Homo sapiens	183-189
25308407-2	2014	As chemotherapy seriously damages the mucosal immune system, we herein demonstrated that polysaccharide from the squid ink of Ommastrephes bartrami (OBP) activated intestinal SIgA secretion to prevent chemotherapeutic injury.	Polysaccharides	89-103	odorant binding protein 2A	Homo sapiens	149-152
25480294-4	2014	Human glycans are unusual because of the lack of CMAH, which in other mammals converts N-acetylneuraminic acid (Neu5Ac) to N-glycolylneuraminic acid (Neu5Gc).	Polysaccharides	6-13	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	49-53
25470427-1	2014	C-type lectin-like receptor 2 (CLEC-2) is a member of the C-type lectin (like) receptor (CLR) family that uses a Ca(2+) binding domain to bind specific glycans.	Polysaccharides	152-159	C-type lectin domain family 1 member B	Homo sapiens	0-29
25470427-1	2014	C-type lectin-like receptor 2 (CLEC-2) is a member of the C-type lectin (like) receptor (CLR) family that uses a Ca(2+) binding domain to bind specific glycans.	Polysaccharides	152-159	C-type lectin domain family 1 member B	Homo sapiens	31-37
25251945-6	2014	The beta-glucan-consisting glycans curdlan and zymosan stimulated IL-8 and CCL2 secretion by IEC lines.	Polysaccharides	27-34	C-X-C motif chemokine ligand 8	Homo sapiens	66-70
25251945-6	2014	The beta-glucan-consisting glycans curdlan and zymosan stimulated IL-8 and CCL2 secretion by IEC lines.	Polysaccharides	27-34	C-C motif chemokine ligand 2	Homo sapiens	75-79
25312704-6	2014	The free fatty acids released after 120 min of lipase digestion were 46, 63, and 81% (w/w) for methyl cellulose, pectin, and chitosan, respectively (3.6% (w/w) initial polysaccharide), indicating that methyl cellulose had the highest capacity to inhibit lipid digestion, followed by pectin, and then chitosan.	Polysaccharides	168-182	lipase	Zea mays	47-53
25049238-5	2014	More importantly, a glycan array screening revealed that single-point mutations in the CBL2 could produce significant changes in the carbohydrate specificity of the protein.	Polysaccharides	20-26	Cbl proto-oncogene	Homo sapiens	87-91
25369125-0	2014	Glycan dependence of Galectin-3 self-association properties.	Polysaccharides	0-6	galectin 3	Homo sapiens	21-31
25263953-5	2014	RESULTS: CD4 T-cell proliferation, upon stimulation with PPD and pneumococcal polysaccharide antigen, was lower among O-IR relative to HIV-negative controls; p=0.016 and p=0.016 respectively.	Polysaccharides	78-92	CD4 molecule	Homo sapiens	9-12
25245803-1	2014	Most Staphylococcus aureus isolates produce either a serotype 5 (CP5) or 8 (CP8) capsular polysaccharide, and the CP antigens are targets for vaccine development.	Polysaccharides	90-104	CP8	Pseudomonas aeruginosa	76-79
25270395-0	2014	Astragalus polysaccharides exert protective effects in newborn rats with bronchopulmonary dysplasia by upregulating the expression of EGFL7 in lung tissue.	Polysaccharides	11-26	EGF-like-domain, multiple 7	Rattus norvegicus	134-139
25275130-6	2014	Compared to viruses with less oligomannose and more complex Env glycans, viruses with more oligomannose and less complex glycans more efficiently (i) transcytosed across an epithelial cell monolayer, (ii) attached to monocyte-derived macrophages (MDMs), (iii) bound monocyte-derived dendritic cells (MoDCs), and (iv) trans-infected primary lymphocytes via MoDCs.	Polysaccharides	64-71	endogenous retrovirus group W member 1, envelope	Homo sapiens	60-63
25275130-8	2014	Thus, N-linked Env glycans display discordant effects on the major events of HIV-1 transmission, with mature oligosaccharide structures on Env playing a crucial role in HIV-1 infection.	Polysaccharides	19-26	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	15-18
25275130-13	2014	We show that N-linked Env glycans display discordant effects on the major events of HIV-1 transmission.	Polysaccharides	26-33	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	22-25
25275130-14	2014	These data indicate that Env glycan moieties impact HIV-1 transmission and that modulation of Env glycan moieties offers a potential strategy for the development of therapeutic or prophylactic vaccines against HIV-1.	Polysaccharides	29-35	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	25-28
25275130-14	2014	These data indicate that Env glycan moieties impact HIV-1 transmission and that modulation of Env glycan moieties offers a potential strategy for the development of therapeutic or prophylactic vaccines against HIV-1.	Polysaccharides	98-104	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	94-97
25412177-0	2014	Bacterial fucose-rich polysaccharide stabilizes MAPK-mediated Nrf2/Keap1 signaling by directly scavenging reactive oxygen species during hydrogen peroxide-induced apoptosis of human lung fibroblast cells.	Polysaccharides	22-36	NFE2 like bZIP transcription factor 2	Homo sapiens	62-66
25412177-0	2014	Bacterial fucose-rich polysaccharide stabilizes MAPK-mediated Nrf2/Keap1 signaling by directly scavenging reactive oxygen species during hydrogen peroxide-induced apoptosis of human lung fibroblast cells.	Polysaccharides	22-36	kelch like ECH associated protein 1	Homo sapiens	67-72
25300029-3	2014	Higher molecular weight glycan structures with a different monosaccharide composition were observed at two sites, namely, Asn-925 and Asn-928 sites in alpha3 integrin isolated from Pkd1(+/+) cells compared with Pkd1(-/-) cells.	Polysaccharides	24-30	polycystin 1, transient receptor potential channel interacting	Mus musculus	181-185
25300029-3	2014	Higher molecular weight glycan structures with a different monosaccharide composition were observed at two sites, namely, Asn-925 and Asn-928 sites in alpha3 integrin isolated from Pkd1(+/+) cells compared with Pkd1(-/-) cells.	Polysaccharides	24-30	polycystin 1, transient receptor potential channel interacting	Mus musculus	211-215
25209833-0	2014	Total polysaccharide of Yupingfeng protects against bleomycin-induced pulmonary fibrosis via inhibiting transforming growth factor-beta1-mediated type I collagen abnormal deposition in rats.	Polysaccharides	6-20	transforming growth factor, beta 1	Rattus norvegicus	104-136
25253346-17	2014	In this study, we targeted the CD4bs by conformational stabilization and additional glycan masking.	Polysaccharides	84-90	CD4 molecule	Homo sapiens	31-34
25253346-18	2014	We used the atomic-level structure to reengineer gp120 cores to preferentially present the cysteine-stabilized CD4bs and to mask (by glycan) nonneutralizing determinants.	Polysaccharides	133-139	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	49-54
25253346-19	2014	Importantly, glycan masking did successfully focus antibody responses to the CD4bs; however, the elicited CD4bs-directed antibodies did not neutralize HIV or bind to unmodified gp120, presumably due to the structure-guided modifications of the modified gp120 core.	Polysaccharides	13-19	CD4 molecule	Homo sapiens	77-80
25253346-19	2014	Importantly, glycan masking did successfully focus antibody responses to the CD4bs; however, the elicited CD4bs-directed antibodies did not neutralize HIV or bind to unmodified gp120, presumably due to the structure-guided modifications of the modified gp120 core.	Polysaccharides	13-19	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	253-258
25455227-1	2014	In the present study, a high-purity polysaccharide from mulberry leaf (MLP) was purified and characterized, and its anti-diabetic effects were investigated in streptozotocin (STZ)-induced diabetic rats.	Polysaccharides	36-50	cysteine and glycine rich protein 3	Rattus norvegicus	71-74
25160934-7	2014	Additionally, the bi-antenary glycan arm onto which galactose was added predicted enhanced binding to FcgammaRIIIa and ADCC activity, independent of the specificity of the mAb.	Polysaccharides	30-36	Fc gamma receptor IIIa	Homo sapiens	102-114
25129769-1	2014	A protein-containing polysaccharide, EPS2BW, was fractionated from the exopolysaccharide (EPS) produced by a medicinal fungus Cordyceps sinensis (Cs-HK1).	Polysaccharides	21-35	hexokinase 1	Rattus norvegicus	149-152
25369125-9	2014	We propose that LNnT induces a release of the N-terminal domain resulting in the glycan-dependent self-association of Galectin-3 through N-terminal domain interactions.	Polysaccharides	81-87	galectin 3	Homo sapiens	118-128
25176445-2	2014	We recently found that PS-F2, a polysaccharide fraction purified from the submerged culture broth of Ganoderma formosanum, stimulates the maturation of dendritic cells and primes a T helper 1 (Th1)-polarized adaptive immune response in vivo.	Polysaccharides	32-46	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	23-28
25234305-3	2014	To date, only a maximum of 12 glycan structures, the most abundant ones, have been identified by CE-LIF to characterize glycome modulations of total serum in the course of the diseases.	Polysaccharides	30-36	LIF interleukin 6 family cytokine	Homo sapiens	100-103
24925318-2	2014	Specific glycans bound to the extracellular portion of dystroglycan, alpha-dystroglycan, mediate ECM interactions and most known dystroglycanopathy genes encode glycosyltransferases involved in glycan synthesis.	Polysaccharides	9-16	dystroglycan 1	Homo sapiens	55-67
24925318-2	2014	Specific glycans bound to the extracellular portion of dystroglycan, alpha-dystroglycan, mediate ECM interactions and most known dystroglycanopathy genes encode glycosyltransferases involved in glycan synthesis.	Polysaccharides	9-16	dystroglycan 1	Homo sapiens	75-87
24925318-2	2014	Specific glycans bound to the extracellular portion of dystroglycan, alpha-dystroglycan, mediate ECM interactions and most known dystroglycanopathy genes encode glycosyltransferases involved in glycan synthesis.	Polysaccharides	9-15	dystroglycan 1	Homo sapiens	55-67
24925318-2	2014	Specific glycans bound to the extracellular portion of dystroglycan, alpha-dystroglycan, mediate ECM interactions and most known dystroglycanopathy genes encode glycosyltransferases involved in glycan synthesis.	Polysaccharides	9-15	dystroglycan 1	Homo sapiens	75-87
24925318-3	2014	POMK, which was found mutated in two dystroglycanopathy cases, is instead involved in a glycan phosphorylation reaction critical for ECM binding, but little is known about the clinical presentation of POMK mutations or of the function of this protein in the muscle.	Polysaccharides	43-49	protein O-mannose kinase	Homo sapiens	0-4
24954883-11	2014	CONCLUSIONS: In children, including HTx patients, CD21-expressing B-cells show a trend to increase with age, corresponding with improved responsiveness to polysaccharide antigens.	Polysaccharides	155-169	complement C3d receptor 2	Homo sapiens	50-54
25004930-10	2014	We expect that the parallel analysis of IgG Fab and Fc, as set up in this paper, will be important for unraveling roles of these glycans in (auto)immunity, which may be mediated via recognition by human lectins or modulation of antigen binding.	Polysaccharides	129-136	FA complementation group B	Homo sapiens	44-47
25142936-4	2014	In brain s-eNPP6 the N-glycans are mainly hybrid and high mannose type structures, reminiscent of processed mannose-6-phosphorylated glycans.	Polysaccharides	23-30	ectonucleotide pyrophosphatase/phosphodiesterase 6	Bos taurus	11-16
25048706-0	2014	Structural characterization by multistage mass spectrometry (MSn) of human milk glycans recognized by human rotaviruses.	Polysaccharides	80-87	moesin	Homo sapiens	61-64
25016576-1	2014	Recent studies have described several broadly neutralizing monoclonal antibodies (bN-mAbs) that recognize glycan-dependent epitopes (GDEs) in the HIV-1 envelope protein, gp120.	Polysaccharides	106-112	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	170-175
25016576-2	2014	These were recovered from HIV-1 infected subjects, and several (e.g., PG9, PG16, CH01, CH03) target glycans in the first and second variable (V1/V2) domain of gp120.	Polysaccharides	100-107	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	159-164
25142936-5	2014	Here we completed characterization of the site-specific glycan structures of bovine brain s-eNPP6, and determined the endo H-sensitivity glycan profiles of s-eNPP6 from bovine liver and kidney.	Polysaccharides	56-62	ectonucleotide pyrophosphatase/phosphodiesterase 6	Bos taurus	92-97
25142936-7	2014	Thus, the non-classical glycan processing pathway of brain eNPP 6 is not due to mannose-6-phosphorylation, suggesting that there is an alternative Golgi glycan-processing pathway of eNPP6 in brain.	Polysaccharides	24-30	ectonucleotide pyrophosphatase/phosphodiesterase 6	Bos taurus	59-65
25152487-4	2014	In an effort to identify the molecular basis of this allelic form of SCA13, we first determined that human KCNC3(WT) and KCNC3(R420H) display disparate post-translational modifications, and the mutant protein has reduced complex glycan adducts.	Polysaccharides	229-235	potassium voltage-gated channel subfamily C member 3	Homo sapiens	121-126
25262930-4	2014	Here, we present methodology that permits identification of GPI-APs liberated directly from the surface of intact mammalian cells through exploitation of their appended glycans to enrich for these proteins ahead of LC-MS/MS analyses.	Polysaccharides	169-176	glucose-6-phosphate isomerase	Homo sapiens	60-63
25092234-7	2014	Analysis of hFXI glycopeptides by LC-MS/MS enabled site-specific glycan profiling and occupancy.	Polysaccharides	65-71	coagulation factor XI	Homo sapiens	12-16
25179861-1	2014	Lysozyme, one of the major albumen antimicrobials, can break down the polysaccharide walls of a broad spectrum of bacteria.	Polysaccharides	70-84	lysozyme C	Anas platyrhynchos	0-8
25176027-10	2014	Antibody binding to HEK and HEK-B4T cells was used to detect an induced antibody response to the B4GALNT2 produced glycan and the results were compared to GTKO PAEC specific non-Gal antibody induction.	Polysaccharides	115-121	beta-1,4 N-acetylgalactosaminyltransferase 2	Sus scrofa	97-105
25176027-17	2014	CONCLUSION: The functional isolation of the porcine B4GALNT2 gene from a PAEC expression library, the pattern of B4GALNT2 gene expression and its sensitization of HEK-B4T cells to antibody binding and complement mediated lysis indicates that the enzymatic activity of porcine B4GALNT2 produces a new immunogenic non-Gal glycan which contributes in part to the non-Gal immune response detected after pig-to-baboon cardiac xenotransplantation.	Polysaccharides	320-326	beta-1,4 N-acetylgalactosaminyltransferase 2	Sus scrofa	52-60
25378944-5	2014	On the other hand, it is now widely accepted that multi-hit steps, including production of aberrantly glycosylated serum IgA1 (first hit), and IgG or IgA autoantibodies that recognize glycan containing epitopes on glycosylated serum IgA1 (second hit) and their subsequent immune complex formation (third hit) and glomerular deposition (fourth hit), are required for continued progression of IgAN.	Polysaccharides	184-190	immunoglobulin heavy constant alpha 1	Homo sapiens	233-237
25378944-5	2014	On the other hand, it is now widely accepted that multi-hit steps, including production of aberrantly glycosylated serum IgA1 (first hit), and IgG or IgA autoantibodies that recognize glycan containing epitopes on glycosylated serum IgA1 (second hit) and their subsequent immune complex formation (third hit) and glomerular deposition (fourth hit), are required for continued progression of IgAN.	Polysaccharides	184-190	IGAN1	Homo sapiens	391-395
25176127-6	2014	Therefore, sulfation of ECM glycans regulates the levels and inhibitory activity of TIMP-3 and modulates ECM turnover, and small mimicries of sulfated glycans may protect the tissue from the excess destruction seen in diseases such as osteoarthritis, cancer, and atherosclerosis.	Polysaccharides	28-35	TIMP metallopeptidase inhibitor 3	Homo sapiens	84-90
25105231-8	2014	TBG1 might act on a small but specific set of polysaccharide containing galactose.	Polysaccharides	46-60	beta-galactosidase	Solanum lycopersicum	0-4
25037330-1	2014	Various amounts of carboxyl groups were introduced at C-6 of the non-ionic, water soluble polysaccharide, i.e. pullulan, by applying the well-established TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl), sodium hypochlorite/sodium bromide oxidation protocol, varying the reaction time.	Polysaccharides	90-104	complement C6	Homo sapiens	54-57
25037389-1	2014	A new water-soluble polysaccharide (SEP-2), with a molecular weight of 6.78 x 10(5)Da, was isolated from Strongylocentrotus nudus eggs under the extraction conditions optimized by response surface methodology (RSM).	Polysaccharides	20-34	apolipoprotein A-I	Mus musculus	36-41
25037415-6	2014	Pharmacological verification tests showed that F. mori crude polysaccharides had good antioxidant and activate alcohol dehydrogenase activities in vitro.	Polysaccharides	61-76	aldo-keto reductase family 1 member A1	Homo sapiens	111-132
25123148-0	2014	Ultrasensitive detection of cancer cells and glycan expression profiling based on a multivalent recognition and alkaline phosphatase-responsive electrogenerated chemiluminescence biosensor.	Polysaccharides	45-51	alkaline phosphatase, placental	Homo sapiens	112-132
25123148-1	2014	A multivalent recognition and alkaline phosphatase (ALP)-responsive electrogenerated chemiluminescence (ECL) biosensor for cancer cell detection and in situ evaluation of cell surface glycan expression was developed on a poly(amidoamine) (PAMAM) dendrimer-conjugated, chemically reduced graphene oxide (rGO) electrode interface.	Polysaccharides	184-190	alkaline phosphatase, placental	Homo sapiens	30-50
25123148-1	2014	A multivalent recognition and alkaline phosphatase (ALP)-responsive electrogenerated chemiluminescence (ECL) biosensor for cancer cell detection and in situ evaluation of cell surface glycan expression was developed on a poly(amidoamine) (PAMAM) dendrimer-conjugated, chemically reduced graphene oxide (rGO) electrode interface.	Polysaccharides	184-190	alkaline phosphatase, placental	Homo sapiens	52-55
25123148-3	2014	The ALP and concanavalin A (Con A) coated gold nanoparticles (Au NPs) nanoprobes allowed the ALP enzyme-catalyzed production of phenols that inhibited the ECL reaction of Ru(bpy)3(2+) on the rGO electrode interface, affording fast and highly sensitive ECL cytosensing and cell surface glycan evaluation.	Polysaccharides	285-291	alkaline phosphatase, placental	Homo sapiens	4-7
25123148-3	2014	The ALP and concanavalin A (Con A) coated gold nanoparticles (Au NPs) nanoprobes allowed the ALP enzyme-catalyzed production of phenols that inhibited the ECL reaction of Ru(bpy)3(2+) on the rGO electrode interface, affording fast and highly sensitive ECL cytosensing and cell surface glycan evaluation.	Polysaccharides	285-291	alkaline phosphatase, placental	Homo sapiens	93-96
25199692-6	2014	The affinity of the Fc mutants for FcgammaRIIIa was directly proportional to the degree of glycan restriction (R(2) = 0.82).	Polysaccharides	91-97	Fc gamma receptor IIIa	Homo sapiens	35-47
25157101-6	2014	Identification of an unusual cysteine bridge pattern and complex type glycans in Nxph1 ensure binding to the second laminin/neurexin/sex hormone binding (LNS2) domain of Nrxn1alpha, but this association does not interfere with Nlgn binding at LNS6.	Polysaccharides	70-77	neurexophilin 1	Homo sapiens	81-86
25124036-9	2014	Supposedly, lectin TFF2 is involved in protection of gastric epithelia via a functional relationship to defense against H. pylori launched by antibiotic alpha1,4-GlcNAc-capped mucin glycans.	Polysaccharides	182-189	trefoil factor 2	Homo sapiens	19-23
25124036-9	2014	Supposedly, lectin TFF2 is involved in protection of gastric epithelia via a functional relationship to defense against H. pylori launched by antibiotic alpha1,4-GlcNAc-capped mucin glycans.	Polysaccharides	182-189	LOC100508689	Homo sapiens	176-181
25124036-0	2014	Human trefoil factor 2 is a lectin that binds alpha-GlcNAc-capped mucin glycans with antibiotic activity against Helicobacter pylori.	Polysaccharides	72-79	LOC100508689	Homo sapiens	66-71
30011685-4	2014	They showed a clear IFN-gamma inducing activity in human PBMCs, which suggests these polysaccharides to have proinflammatory effects.	Polysaccharides	85-100	interferon gamma	Homo sapiens	20-29
25279697-5	2014	Our results further define the functional O-mannosylated glycan structure and indicate that B4GAT1 is involved in the initiation of the LARGE-dependent repeating disaccharide that is necessary for extracellular matrix protein binding to O-mannosylated alpha-dystroglycan that is lacking in secondary dystroglycanopathies.	Polysaccharides	57-63	beta-1,4-glucuronyltransferase 1	Homo sapiens	92-98
25112602-0	2014	Cartilage polysaccharide induces apoptosis in K562 cells through a reactive oxygen species-mediated caspase pathway.	Polysaccharides	10-24	caspase 8	Homo sapiens	100-107
25112602-6	2014	As caspase-3/7, 8 and 9 were expressed, it was speculated that both intrinsic and extrinsic pathways were involved in the PS-induced apoptosis.	Polysaccharides	122-124	caspase 3	Homo sapiens	3-23
25106027-3	2014	Mucin glycans act as binding sites or carbon sources for the intestinal microbes, thereby functioning as a host-specific determinant affecting the microbiota composition and human health.	Polysaccharides	6-13	LOC100508689	Homo sapiens	0-5
25106027-4	2014	Reflecting the structural diversity of mucin glycans and their prime location, commensal and pathogenic microbes have evolved a range of adhesins allowing their interaction with the host.	Polysaccharides	45-52	LOC100508689	Homo sapiens	39-44
30011685-5	2014	Treatment by beta-glucosidase caused the polysaccharides to be degraded into smaller fragments and at the same time increased their IFN-gamma inducing activity in PBMCs fourfold.	Polysaccharides	41-56	interferon gamma	Homo sapiens	132-141
24795221-8	2014	These findings show that OS-9 delivers mutant neuroserpin to ERAD by recognition of glycan side chains and provide the first in vivo proof of involvement of ERAD in degradation of mutant neuroserpin.	Polysaccharides	84-90	amplified in osteosarcoma	Mus musculus	25-29
25587330-1	2014	A water soluble polysaccharide, HB-1, with a molecular weight of 23,930, was isolated from radix Ranunculi ternati.	Polysaccharides	16-30	histocompatibility minor HB-1	Homo sapiens	32-36
24683196-5	2014	RESULTS: Ficolin-2 bound ST11A capsule polysaccharide and other wcjE-containing pneumococcal serotypes, except ST9V and ST20B.	Polysaccharides	39-53	ficolin 2	Homo sapiens	9-18
24683196-10	2014	CONCLUSIONS: Ficolin-2 mediates serum protection by recognizing specific O-acetylated epitopes of pneumococcal capsule polysaccharides, exemplifying a novel host-microbe interaction that innately offers serotype-specific immunity to IPD.	Polysaccharides	119-134	ficolin 2	Homo sapiens	13-22
24795221-8	2014	These findings show that OS-9 delivers mutant neuroserpin to ERAD by recognition of glycan side chains and provide the first in vivo proof of involvement of ERAD in degradation of mutant neuroserpin.	Polysaccharides	84-90	serine (or cysteine) peptidase inhibitor, clade I, member 1	Mus musculus	46-57
25132301-6	2014	METHODS: N-Glycans were released from ribonuclease B, ovalbumin and gp120 with endoH to give high-mannose and hybrid glycans, and from IgG with endoS to produce biantennary complex glycans, all missing the reducing-terminal GlcNAc residue.	Polysaccharides	117-124	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	68-73
25895394-1	2014	OBJECTIVE: To study the protective effect of polysaccharides from corn silk (PCS) against cyclophosphamide (CTX) induced host damages in mice bearing H22 tumors.	Polysaccharides	45-60	V-set and immunoglobulin domain containing 2	Mus musculus	108-111
25132301-6	2014	METHODS: N-Glycans were released from ribonuclease B, ovalbumin and gp120 with endoH to give high-mannose and hybrid glycans, and from IgG with endoS to produce biantennary complex glycans, all missing the reducing-terminal GlcNAc residue.	Polysaccharides	181-188	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	68-73
25259921-2	2014	Here, we examine how a particularly potent family of broadly neutralizing antibodies (Abs) has evolved common and distinct structural features to counter the glycan shield and interact with both glycan and protein components of HIV Env.	Polysaccharides	195-201	endogenous retrovirus group K member 20	Homo sapiens	232-235
24906778-3	2014	The surface plasmon response (SPR) technology indicated that CS3 could bind with recombinant HBsAg and the binding ability depended on the content of sulfate groups on the polysaccharide chains.	Polysaccharides	172-186	myozenin 3	Homo sapiens	61-64
25246061-9	2014	These findings concluded that stable fatty acid components and activated PPAR-alpha by polysaccharides may contribute to its hypoglycemic and hypolipidemic properties.	Polysaccharides	87-102	peroxisome proliferator activated receptor alpha	Rattus norvegicus	73-83
25078100-7	2014	Both human RNase 1 and bovine brain RNase are readily endocytosed by mammalian cells, aided by tight interactions with cell surface glycans.	Polysaccharides	132-139	ribonuclease A family member 1, pancreatic	Homo sapiens	11-18
25207644-13	2014	gambiae was also found to promote agglutination of HL-60 cells which are rich in sialyl Lewis X, a glycan that decorates PSGL-1, the neutrophils receptor that interacts with endothelial cell P-selectin.	Polysaccharides	99-105	selectin P ligand	Homo sapiens	121-127
24933018-2	2014	In this study, we investigated the preventive effects of daily supplementation with an homogeneous polysaccharide (DHP) purified from D. huoshanense on ethanol-induced subacute liver injury in mice and its potential mechanisms in liver protection by a proteomic approach.	Polysaccharides	99-113	dihydropyrimidinase	Mus musculus	115-118
24965454-2	2014	2G12 is a unique, domain-exchanged antibody that binds exclusively to conserved N-linked glycans that form the high-mannose patch on the gp120 outer domain centered on a glycan at position N332.	Polysaccharides	89-95	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	137-142
24965454-3	2014	Several glycans in and around the 2G12 epitope have been shown to interact with other potent, broadly neutralizing antibodies; therefore, this region constitutes a supersite of vulnerability on gp120.	Polysaccharides	8-15	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	194-199
24981893-0	2014	Induction of death receptor CD95 and co-stimulatory molecules CD80 and CD86 by meningococcal capsular polysaccharide-loaded vaccine nanoparticles.	Polysaccharides	102-116	Fas cell surface death receptor	Homo sapiens	28-32
24981893-0	2014	Induction of death receptor CD95 and co-stimulatory molecules CD80 and CD86 by meningococcal capsular polysaccharide-loaded vaccine nanoparticles.	Polysaccharides	102-116	CD80 molecule	Homo sapiens	62-66
24981893-0	2014	Induction of death receptor CD95 and co-stimulatory molecules CD80 and CD86 by meningococcal capsular polysaccharide-loaded vaccine nanoparticles.	Polysaccharides	102-116	CD86 molecule	Homo sapiens	71-75
24769397-0	2014	Glycan specificity of a testis-specific lectin chaperone calmegin and effects of hydrophobic interactions.	Polysaccharides	0-6	calmegin	Homo sapiens	57-65
24769397-3	2014	Although functional similarity between calnexin and calmegin has been predicted, detailed information concerned with substrate recognition by calmegin, such as glycan specificity, chaperone function and binding affinity, are obscure.	Polysaccharides	160-166	calmegin	Homo sapiens	142-150
24769397-4	2014	METHODS: In this study, biochemical properties of calmegin and calnexin were compared using synthetic glycans and glycosylated or non-glycosylated proteins as substrates.	Polysaccharides	102-109	calmegin	Homo sapiens	50-58
24769397-4	2014	METHODS: In this study, biochemical properties of calmegin and calnexin were compared using synthetic glycans and glycosylated or non-glycosylated proteins as substrates.	Polysaccharides	102-109	calnexin	Homo sapiens	63-71
24769397-7	2014	Similarly to calnexin, calmegin preferentially recognizes monoglucosylated glycans such as Glc1Man9GlcNAc2 (G1M9).	Polysaccharides	75-82	calmegin	Homo sapiens	23-31
25036608-0	2014	A polysaccharide from Sanguisorbae radix induces caspase-dependent apoptosis in human leukemia HL-60 cells.	Polysaccharides	2-16	caspase 8	Homo sapiens	49-56
24496316-8	2014	These observations suggest that IgG-Fc has a glycan-dependent "muco-trapping" effector function that may provide exceptionally potent protection at mucosal surfaces.	Polysaccharides	45-51	immunoglobulin heavy variable V1-62	Mus musculus	32-35
25369249-4	2014	These findings implied that the glycan containing terminal fructose, GalNacalpha, terminal beta1-4 galactose,and bisecting GlcNAc glycan structures dropped to near control levels, while the terminal beta-D-galactose residues and core fructose structure increased significantly.	Polysaccharides	32-38	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	91-98
25157844-3	2014	In addition, AtBFN2"s enzymatic activity is strongly glycan dependent.	Polysaccharides	53-59	endonuclease 2	Arabidopsis thaliana	13-19
25094044-1	2014	Here we report glycan structures and their position of attachment to a carrier protein, uridine 5"-diphosphate-glucose: glycoprotein glucosyltransferase (UGGT1), as detected using tandem mass spectrometry.	Polysaccharides	15-21	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	154-159
25094044-3	2014	The structure of glycan attached to UGGT1, however, has not been investigated.	Polysaccharides	17-23	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	36-41
25094044-4	2014	In this study, we reveal the site of glycosylation (N269) and the glycan structures (Hex5-8HexNAc2) in UGGT1 obtained from rat (Rattus norvegicus), pig (Sus scrofa), cow (Bos taurus), and human (Homo sapiens).	Polysaccharides	66-72	UDP-glucose glycoprotein glucosyltransferase 1	Rattus norvegicus	103-108
25178064-4	2014	In this work, a crude polysaccharide of M. charantia (MCP) fruit was isolated by hot water extraction and then purified using DEAE-52 cellulose anion-exchange chromatography to produce two main fractions MCP1 and MCP2.	Polysaccharides	22-36	complement component (3b/4b) receptor 1-like	Mus musculus	54-57
25037226-6	2014	In addition, we determined that glycosphingolipids (GSLs), a group of membrane glycolipids, are highly abundant in the exosomes, and the enriched glycans of the GSLs are essential for Abeta binding and assembly on the exosomes both in vitro and in vivo.	Polysaccharides	146-153	amyloid beta (A4) precursor protein	Mus musculus	184-189
25095792-4	2014	RESULTS: Three different molecular weight glycans (lactose and two dextrans with 1 kD and 10 kD) were chemically coupled to surface exposed Cyt c lysine (Lys) residues using succinimidyl chemistry via amide bonds.	Polysaccharides	42-49	cytochrome c, somatic	Homo sapiens	140-145
25395712-7	2014	The data also revealed that cactus polysaccharides cause apoptosis in SK-MES-1 cells determined by Annexin-V assay.	Polysaccharides	35-50	annexin A5	Homo sapiens	99-108
25395712-8	2014	Furthermore, cactus polysaccharides induced growth arrest and apoptosis may be due to the increase of P53 and phosphatase and tension homolog deleted on chromosome ten (PTEN) protein.	Polysaccharides	20-35	tumor protein p53	Homo sapiens	102-105
25395712-8	2014	Furthermore, cactus polysaccharides induced growth arrest and apoptosis may be due to the increase of P53 and phosphatase and tension homolog deleted on chromosome ten (PTEN) protein.	Polysaccharides	20-35	phosphatase and tensin homolog	Homo sapiens	169-173
24993945-1	2014	Polysialic acid (polySia) is a unique glycan modification of the neural cell adhesion molecule NCAM and a major determinant of brain development.	Polysaccharides	38-44	neural cell adhesion molecule 1	Mus musculus	95-99
24719303-2	2014	Spectral data of the intact glycan moiety of RNase B is obtained by subtracting high-quality spectral data of RNase A, the non-glycosylated form of the RNase, from the spectra of the glycoprotein.	Polysaccharides	28-34	ribonuclease A family member 1, pancreatic	Homo sapiens	110-117
25022802-2	2014	In this work, a new strategy was developed for isomer-specific glycan profiling using nanoLC-MS with PGC as the stationary phase.	Polysaccharides	63-69	progastricsin	Homo sapiens	101-104
25120578-9	2014	RESULTS: We demonstrated, using ELISA, that gp120 glycans sterically adjacent to the V3 loop only moderately contribute to differential recognition of a short apex motif GPGRA and GPGR by monoclonal antibodies F425 B4e8 and 447-52D, respectively.	Polysaccharides	50-57	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	44-49
25010042-4	2014	The mechanism of glycan recognition on the gp120 envelope protein by these antiviral lectins may therefore be exploited for developing agents and alternative strategies to prevent HIV transmission.	Polysaccharides	17-23	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	43-48
24752529-0	2014	The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by polysaccharides from Angelica sinensis in rats with iron deficiency anemia.	Polysaccharides	75-90	Eph receptor B1	Rattus norvegicus	28-31
24976257-8	2014	Our results lead us to propose that the DC-SIGNR CRD rapidly and reversibly releases glycan ligands and Ca(2+) at reduced pH (behaviour that would be expected for an endocytic receptor), and that the binding of mannose-containing oligosaccharides is more strongly affected by pH than the binding of GlcNAc-containing oligosaccharides.	Polysaccharides	85-91	C-type lectin domain family 4 member M	Homo sapiens	40-48
24963069-4	2014	APTG1 encodes a putative mannosyltransferase homolog to human PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS B and yeast (Saccharomyces cerevisiae) GLYCOSYLPHOSPHATIDYLINOSITOL10 (GPI10), both of which are involved in the biosynthesis of GPI anchors.	Polysaccharides	83-89	Alg9-like mannosyltransferase family	Arabidopsis thaliana	0-5
24963069-4	2014	APTG1 encodes a putative mannosyltransferase homolog to human PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS B and yeast (Saccharomyces cerevisiae) GLYCOSYLPHOSPHATIDYLINOSITOL10 (GPI10), both of which are involved in the biosynthesis of GPI anchors.	Polysaccharides	83-89	putative glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase	Saccharomyces cerevisiae S288C	149-179
24963069-4	2014	APTG1 encodes a putative mannosyltransferase homolog to human PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS B and yeast (Saccharomyces cerevisiae) GLYCOSYLPHOSPHATIDYLINOSITOL10 (GPI10), both of which are involved in the biosynthesis of GPI anchors.	Polysaccharides	83-89	putative glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase	Saccharomyces cerevisiae S288C	181-186
25030450-4	2014	Here we applied single-molecule-based approaches to directly visualize the impact of glycan-based interactions on the spatiotemporal organization and interaction with clathrin of the glycosylated pathogen recognition receptor dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN).	Polysaccharides	85-91	CD209 molecule	Homo sapiens	226-304
25030450-4	2014	Here we applied single-molecule-based approaches to directly visualize the impact of glycan-based interactions on the spatiotemporal organization and interaction with clathrin of the glycosylated pathogen recognition receptor dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN).	Polysaccharides	85-91	CD209 molecule	Homo sapiens	306-313
24872420-6	2014	Because the gp120 vaccine immunogens used in previous HIV-1 vaccine trials were enriched for complex sialic acid-containing glycans, and lacked the high mannose structures required for the binding of PG9-like mAbs, we wondered if these immunogens could be improved by limiting glycosylation to mannose-5 glycans.	Polysaccharides	124-131	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	12-17
25120548-0	2014	Loss of Arabidopsis GAUT12/IRX8 causes anther indehiscence and leads to reduced G lignin associated with altered matrix polysaccharide deposition.	Polysaccharides	120-134	galacturonosyltransferase 12	Arabidopsis thaliana	20-26
25120548-0	2014	Loss of Arabidopsis GAUT12/IRX8 causes anther indehiscence and leads to reduced G lignin associated with altered matrix polysaccharide deposition.	Polysaccharides	120-134	galacturonosyltransferase 12	Arabidopsis thaliana	27-31
24752529-0	2014	The action of JAK, SMAD and ERK signal pathways on hepcidin suppression by polysaccharides from Angelica sinensis in rats with iron deficiency anemia.	Polysaccharides	75-90	hepcidin antimicrobial peptide	Rattus norvegicus	51-59
24752529-1	2014	A crude polysaccharide was obtained by water extraction and ethanol precipitation from the root of Angelica sinensis (AS) to investigate its suppressive effect on hepcidin expression in rats with iron deficiency anemia (IDA).	Polysaccharides	8-22	hepcidin antimicrobial peptide	Rattus norvegicus	163-171
25012725-0	2014	Khz-cp (crude polysaccharide extract obtained from the fusion of Ganoderma lucidum and Polyporus umbellatus mycelia) induces apoptosis by increasing intracellular calcium levels and activating P38 and NADPH oxidase-dependent generation of reactive oxygen species in SNU-1 cells.	Polysaccharides	14-28	mitogen-activated protein kinase 14	Homo sapiens	193-196
24861606-7	2014	RESULTS: The DESI-MS results revealed statistically different ATN desorption trends as a function of the polysaccharide investigated and the pH of the desorbing solution.	Polysaccharides	105-119	desumoylating isopeptidase 2	Homo sapiens	13-17
24908430-0	2014	A polysaccharide from Grifola frondosa relieves insulin resistance of HepG2 cell by Akt-GSK-3 pathway.	Polysaccharides	2-16	AKT serine/threonine kinase 1	Homo sapiens	84-87
24879441-6	2014	In addition, a C. elegans gene, termed samt-1, coding for a candidate membrane transport protein for the presumptive donor substrate of glycan methylation, S-adenosyl-methionine, from the cytoplasm to the Golgi was identified.	Polysaccharides	136-142	Major facilitator superfamily domain-containing protein 5	Caenorhabditis elegans	39-45
24884609-0	2014	Site-specific glycan microheterogeneity of inter-alpha-trypsin inhibitor heavy chain H4.	Polysaccharides	14-20	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	43-87
24746228-5	2014	Thiol modified glycans were covalently bound to a model protein carrier, maleimide functionalized bovine serum albumin (BSA), and the number of glycans per BSA modulated.	Polysaccharides	15-22	albumin	Homo sapiens	105-118
24992528-9	2014	Essential elements of the glycan V3 supersite, embodied by as few as 3 N-linked glycans and ~ 25 Env residues, can be segregated into acceptor scaffolds away from the immune-evading capabilities of the rest of HIV-1 Env, thereby providing a means to focus the immune response on the scaffolded supersite.	Polysaccharides	26-32	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	97-100
24992528-9	2014	Essential elements of the glycan V3 supersite, embodied by as few as 3 N-linked glycans and ~ 25 Env residues, can be segregated into acceptor scaffolds away from the immune-evading capabilities of the rest of HIV-1 Env, thereby providing a means to focus the immune response on the scaffolded supersite.	Polysaccharides	26-32	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	216-219
24855102-9	2014	Beta 1 integrin, a target protein of galectin-3, was expressed in bovine CL and possessed glycans, which galectin-3 binds.	Polysaccharides	90-97	galectin 3	Bos taurus	37-47
24855102-9	2014	Beta 1 integrin, a target protein of galectin-3, was expressed in bovine CL and possessed glycans, which galectin-3 binds.	Polysaccharides	90-97	galectin 3	Bos taurus	105-115
24855102-10	2014	Furthermore, galectin-3 bound to glycans of luteal beta 1 integrin.	Polysaccharides	33-40	galectin 3	Bos taurus	13-23
24547957-11	2014	In conclusion, our study suggests that MBL-deficient adults with RRTI have a response to a pneumococcal capsular polysaccharide vaccine comparable with MBL-sufficient patients.	Polysaccharides	113-127	mannose binding lectin 2	Homo sapiens	39-42
24751973-2	2014	This study was aimed to clarify the role of CS-P, a polysaccharide fraction isolated from Cordyceps sobolifera, in modulating nephrofunctional damage in a rat model of endotoxemia.	Polysaccharides	52-66	DnaJ heat shock protein family (Hsp40) member C5	Rattus norvegicus	44-48
24718258-1	2014	As a member of beta-galactoside-binding proteins family, Galectin-1 (Gal-1) contains a single carbohydrate recognition domain, by means of which it can bind glycans both as a monomer and as a homodimer.	Polysaccharides	157-164	galectin 1	Homo sapiens	69-74
24808176-11	2014	Overall, our results demonstrate that even minor changes in active site architecture have a significant effect on the substrate specificity of Smlt1473, whose structural plasticity could be applied to the design of highly active and specific polysaccharide lyases.	Polysaccharides	242-256	polysaccharide lyase	Stenotrophomonas maltophilia K279a	143-151
24854630-8	2014	ELISA using PSA, PAP, and MUC1 capture antibodies and a specific core 2 O-linked sLe(x) detection antibody demonstrated elevation of this glycan structure in cancer compared to normal tissues for MUC1 (P = 0.01), PSA (P = 0.03) and near significant differences in PAP sLe(x) levels (P = 0.06).	Polysaccharides	138-144	kallikrein related peptidase 3	Homo sapiens	12-15
24854630-8	2014	ELISA using PSA, PAP, and MUC1 capture antibodies and a specific core 2 O-linked sLe(x) detection antibody demonstrated elevation of this glycan structure in cancer compared to normal tissues for MUC1 (P = 0.01), PSA (P = 0.03) and near significant differences in PAP sLe(x) levels (P = 0.06).	Polysaccharides	138-144	mucin 1, cell surface associated	Homo sapiens	196-200
24854630-8	2014	ELISA using PSA, PAP, and MUC1 capture antibodies and a specific core 2 O-linked sLe(x) detection antibody demonstrated elevation of this glycan structure in cancer compared to normal tissues for MUC1 (P = 0.01), PSA (P = 0.03) and near significant differences in PAP sLe(x) levels (P = 0.06).	Polysaccharides	138-144	kallikrein related peptidase 3	Homo sapiens	213-216
24983858-5	2014	The method was applied to the separation of neo-glycoproteins prepared starting from the model protein RNase A by chemical conjugation of different glycans.	Polysaccharides	148-155	ribonuclease A family member 1, pancreatic	Homo sapiens	103-110
24967714-7	2014	Finally, we show that mutant N260Q gp160 was cleaved to gp120 and gp41 to a much lower extent than wild-type gp160, and that it was subject of lysosomal degradation to a higher extent than wild-type gp160 showing a prominent role of this process in the breakdown of N260-glycan-deleted gp160, which could not be counteracted by the S128N mutation.	Polysaccharides	271-277	glutamyl aminopeptidase	Homo sapiens	35-40
25114834-0	2014	Linking tumor hypoxia with VEGFR2 signaling and compensatory angiogenesis: Glycans make the difference.	Polysaccharides	75-82	kinase insert domain receptor	Homo sapiens	27-33
24797875-1	2014	We report on the fabrication and characterization of a freestanding ultrathin, mucoadhesive gold nanoshell/polysaccharide multilayer nanocomposite (thermonanofilm, TNF), that can be used for controlled photothermal ablation of tissues through irradiation with near-infrared radiation (NIR) laser.	Polysaccharides	107-121	tumor necrosis factor	Homo sapiens	164-167
24967714-2	2014	Of the, on average, 24 N-linked glycans present on gp120, the glycan at Asn260 was reported to be essential for the correct expression of gp120 and gp41 in the virus particle and deletion of the N260 glycan in gp120 heavily compromised virus infectivity.	Polysaccharides	32-38	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	51-56
24967714-2	2014	Of the, on average, 24 N-linked glycans present on gp120, the glycan at Asn260 was reported to be essential for the correct expression of gp120 and gp41 in the virus particle and deletion of the N260 glycan in gp120 heavily compromised virus infectivity.	Polysaccharides	62-68	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	51-56
24967714-2	2014	Of the, on average, 24 N-linked glycans present on gp120, the glycan at Asn260 was reported to be essential for the correct expression of gp120 and gp41 in the virus particle and deletion of the N260 glycan in gp120 heavily compromised virus infectivity.	Polysaccharides	62-68	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	138-143
24967714-2	2014	Of the, on average, 24 N-linked glycans present on gp120, the glycan at Asn260 was reported to be essential for the correct expression of gp120 and gp41 in the virus particle and deletion of the N260 glycan in gp120 heavily compromised virus infectivity.	Polysaccharides	62-68	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	138-143
24721094-5	2014	After precipitation with ethanol at final concentration of 40%, 60% and 80% in turn, three polysaccharide fractions of JSP1, JSP2 and JSP3 were obtained from JSP, respectively.	Polysaccharides	91-105	dual specificity phosphatase 22	Homo sapiens	119-123
24945257-10	2014	Taken together, our results suggest that the conjugated glycans of acutobin are involved in its interaction with fibrinogen, and that the selection of cells optimally expressing efficient glycoforms and further glycosylation engineering are desirable before a recombinant product can replace the native enzyme for clinical use.	Polysaccharides	56-63	fibrinogen beta chain	Homo sapiens	113-123
24681004-5	2014	We identified a mutation in the Drosophila gene, xiantuan (xit, CG4542), which encodes one of the conserved enzymes involved in addition of the terminal glucose residues to the glycan precursor.	Polysaccharides	177-183	xiantuan	Drosophila melanogaster	49-57
24790092-4	2014	We observed that ZG16p preferentially binds to alpha-mannose-terminating short glycans such as Ser/Thr-linked O-mannose, but not to high mannose-type N-glycans.	Polysaccharides	79-86	zymogen granule protein 16	Homo sapiens	17-22
24681004-5	2014	We identified a mutation in the Drosophila gene, xiantuan (xit, CG4542), which encodes one of the conserved enzymes involved in addition of the terminal glucose residues to the glycan precursor.	Polysaccharides	177-183	xiantuan	Drosophila melanogaster	64-70
24795453-5	2014	Mice carrying a myeloid-specific knockout of the Mgat2 gene encoding UDP-GlcNAc:alpha-6-d-mannoside beta-1,2-N-acetylglucosaminyltransferase II enzyme exhibit deficiencies in IgG responses to both protein and polysaccharide conjugate vaccines.	Polysaccharides	209-223	mannoside acetylglucosaminyltransferase 2	Mus musculus	49-54
32481817-0	2014	Polysaccharide electrospun fibers with sulfated poly(fucose) promote endothelial cell migration and VEGF-mediated angiogenesis.	Polysaccharides	0-14	vascular endothelial growth factor A	Mus musculus	100-104
24927126-0	2014	Development of a highly sensitive glycan microarray for quantifying AFP-L3 for early prediction of hepatitis B virus-related hepatocellular carcinoma.	Polysaccharides	34-40	alpha fetoprotein	Homo sapiens	68-71
32261469-8	2014	Collectively, the LHRH-mediated polysaccharide nanoparticles appeared to be a promising nanomedicine drug delivery system for tumor-targeted delivery of cisplatin.	Polysaccharides	32-46	gonadotropin releasing hormone 1	Mus musculus	18-22
24927126-6	2014	Glycan microarrays showed that the AFP-L3 ratio of HBV-related HCC patients was significantly higher than that measured for chronic hepatitis B patients.	Polysaccharides	0-6	alpha fetoprotein	Homo sapiens	35-38
24927126-13	2014	Our results describe a new glycan microarray for the sensitive and rapid quantification of fucosylated AFP; this method is potentially applicable to screening changes in AFP-L3 level for assessment of HCC progression.	Polysaccharides	27-33	alpha fetoprotein	Homo sapiens	103-106
24927126-13	2014	Our results describe a new glycan microarray for the sensitive and rapid quantification of fucosylated AFP; this method is potentially applicable to screening changes in AFP-L3 level for assessment of HCC progression.	Polysaccharides	27-33	alpha fetoprotein	Homo sapiens	170-173
25019045-3	2014	We recently found that PS-F2, a polysaccharide fraction purified from the submerged culture broth of Ganoderma formosanum, stimulates the activation of dendritic cells and primes a T helper 1 (Th1)-polarized adaptive immune response.	Polysaccharides	32-46	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	23-28
32481817-3	2014	In this study, we demonstrate a simple approach to incorporate VEGF into polysaccharide electrospun fibers by taking advantage of the interactions between VEGF and sulfated polysaccharide, fucoidan.	Polysaccharides	73-87	vascular endothelial growth factor A	Mus musculus	63-67
32481817-3	2014	In this study, we demonstrate a simple approach to incorporate VEGF into polysaccharide electrospun fibers by taking advantage of the interactions between VEGF and sulfated polysaccharide, fucoidan.	Polysaccharides	73-87	vascular endothelial growth factor A	Mus musculus	155-159
32481817-3	2014	In this study, we demonstrate a simple approach to incorporate VEGF into polysaccharide electrospun fibers by taking advantage of the interactions between VEGF and sulfated polysaccharide, fucoidan.	Polysaccharides	173-187	vascular endothelial growth factor A	Mus musculus	63-67
24901527-3	2014	The crude tea polysaccharides (TPS1 and TPS2) were obtained from green tea leaves by hot water extraction and followed by 40% and 70% ethanol precipitation, respectively.	Polysaccharides	14-29	tryptase beta 2	Homo sapiens	40-44
24901527-4	2014	Two homogenous water soluble polysaccharides (TPS1-2a and TPS1-2b) were obtained from TPS1 after purification with gel permeation, which gave a higher phagocytic effect than TPS2.	Polysaccharides	29-44	tryptase alpha/beta 1	Homo sapiens	46-50
24901527-3	2014	The crude tea polysaccharides (TPS1 and TPS2) were obtained from green tea leaves by hot water extraction and followed by 40% and 70% ethanol precipitation, respectively.	Polysaccharides	14-29	tryptase alpha/beta 1	Homo sapiens	31-35
24901527-4	2014	Two homogenous water soluble polysaccharides (TPS1-2a and TPS1-2b) were obtained from TPS1 after purification with gel permeation, which gave a higher phagocytic effect than TPS2.	Polysaccharides	29-44	tryptase alpha/beta 1	Homo sapiens	58-62
24901527-4	2014	Two homogenous water soluble polysaccharides (TPS1-2a and TPS1-2b) were obtained from TPS1 after purification with gel permeation, which gave a higher phagocytic effect than TPS2.	Polysaccharides	29-44	tryptase alpha/beta 1	Homo sapiens	58-62
24901527-4	2014	Two homogenous water soluble polysaccharides (TPS1-2a and TPS1-2b) were obtained from TPS1 after purification with gel permeation, which gave a higher phagocytic effect than TPS2.	Polysaccharides	29-44	tryptase beta 2	Homo sapiens	174-178
24892697-9	2014	The biological relevance of the direct interaction of ArtinM with TLR2 glycans was assessed using macrophages from TLR2-KOmice, which produced significantly lower levels of IL-12 and IL-10 in response to ArtinM than macrophages from wild-type mice.	Polysaccharides	71-78	toll-like receptor 2	Mus musculus	66-70
24835176-4	2014	Our glycan microarray showed a unique affinity profile of chemokine CCL20 to substructures of heparin and heparin-like oligo/di/monosaccharides.	Polysaccharides	4-10	chemokine (C-C motif) ligand 20	Mus musculus	68-73
24892697-9	2014	The biological relevance of the direct interaction of ArtinM with TLR2 glycans was assessed using macrophages from TLR2-KOmice, which produced significantly lower levels of IL-12 and IL-10 in response to ArtinM than macrophages from wild-type mice.	Polysaccharides	71-78	toll-like receptor 2	Mus musculus	115-119
24769153-2	2014	Modifications to the glycan backbone of peptidoglycan are generally restricted to the C-6 hydroxyl and C-3 amino moieties, with the most common being acetylation and deacetylation.	Polysaccharides	21-27	complement C6	Homo sapiens	86-89
24769153-2	2014	Modifications to the glycan backbone of peptidoglycan are generally restricted to the C-6 hydroxyl and C-3 amino moieties, with the most common being acetylation and deacetylation.	Polysaccharides	21-27	complement C3	Homo sapiens	103-106
24680813-2	2014	The polysaccharide moiety of MT2-A was mainly composed of mannose and trace amount of glucose.	Polysaccharides	4-18	metallothionein 2A	Homo sapiens	29-34
24561343-0	2014	Glycan-dependent binding of galectin-1 to neuropilin-1 promotes axonal regeneration after spinal cord injury.	Polysaccharides	0-6	galectin 1	Homo sapiens	28-38
24561343-0	2014	Glycan-dependent binding of galectin-1 to neuropilin-1 promotes axonal regeneration after spinal cord injury.	Polysaccharides	0-6	neuropilin 1	Homo sapiens	42-54
24561343-2	2014	Here, we show that galectin-1 (Gal-1), an endogenous glycan-binding protein, selectively bound to the NRP-1/PlexinA4 receptor complex in injured neurons through a glycan-dependent mechanism, interrupts the Sema3A pathway and contributes to axonal regeneration and locomotor recovery after SCI.	Polysaccharides	53-59	galectin 1	Homo sapiens	19-29
24561343-2	2014	Here, we show that galectin-1 (Gal-1), an endogenous glycan-binding protein, selectively bound to the NRP-1/PlexinA4 receptor complex in injured neurons through a glycan-dependent mechanism, interrupts the Sema3A pathway and contributes to axonal regeneration and locomotor recovery after SCI.	Polysaccharides	53-59	galectin 1	Homo sapiens	31-36
24561343-2	2014	Here, we show that galectin-1 (Gal-1), an endogenous glycan-binding protein, selectively bound to the NRP-1/PlexinA4 receptor complex in injured neurons through a glycan-dependent mechanism, interrupts the Sema3A pathway and contributes to axonal regeneration and locomotor recovery after SCI.	Polysaccharides	53-59	neuropilin 1	Homo sapiens	102-107
24561343-2	2014	Here, we show that galectin-1 (Gal-1), an endogenous glycan-binding protein, selectively bound to the NRP-1/PlexinA4 receptor complex in injured neurons through a glycan-dependent mechanism, interrupts the Sema3A pathway and contributes to axonal regeneration and locomotor recovery after SCI.	Polysaccharides	53-59	plexin A4	Homo sapiens	108-116
24608027-3	2014	In vitro antioxidant assays showed that the polysaccharides HLP possessed significant inhibitory effects on superoxide radical.	Polysaccharides	44-59	HLP	Homo sapiens	60-63
24631548-2	2014	The r-EPS1 and r-EPS2 were homogenous polysaccharides with average molecular weights of, respectively, 204.6 and 202.8kDa, and composed of glucose, mannose and galactose with molar ratios of 18.21:78.76:3.03 and 12.92:30.89:56.19, respectively.	Polysaccharides	38-53	RALBP1 associated Eps domain containing 1	Homo sapiens	4-21
24820230-6	2014	MLR was inhibited by bovine lactoferrin (bLF), a glycoform that has a more complex glycan structure.	Polysaccharides	83-89	lactotransferrin	Bos taurus	28-39
24519758-2	2014	A growing body of evidence suggests that glycans could mediate lactoferrin"s bioactivity.	Polysaccharides	41-48	lactotransferrin	Capra hircus	63-74
24680813-5	2014	Based on the experimental results, it was concluded that the polysaccharide moiety of MT2-A had a backbone of (1 6)-alpha-D-mannopyranose residues, which highly branched at O-2 position of (1 2,6)-alpha-D-mannopyranose residues.	Polysaccharides	61-75	metallothionein 2A	Homo sapiens	86-91
24638056-0	2014	Inhibition of HepG2 cell proliferation by ursolic acid and polysaccharides via the downregulation of cyclooxygenase-2.	Polysaccharides	59-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	101-117
24678780-5	2014	RESULTS: Synthetic glycans inhibited the growth of glioblastoma cells, induced the apoptosis of the cells with cleaved poly (adenosine diphosphate-ribose) polymerase (PARP) expression and DNA fragmentation, and also caused autophagy, as shown by the detection of autophagosome proteins and monodansylcadaverine staining.	Polysaccharides	19-26	poly (ADP-ribose) polymerase family, member 1	Mus musculus	167-171
24648448-0	2014	Crystallographic and glycan microarray analysis of human polyomavirus 9 VP1 identifies N-glycolyl neuraminic acid as a receptor candidate.	Polysaccharides	21-27	VP1	Human polyomavirus 9	72-75
24681647-3	2014	Here, we describe the synthesis of a polysaccharide-based hydrogel that can be locally injected into tissues and releases a recombinant tissue inhibitor of MMPs (rTIMP-3) in response to MMP activity.	Polysaccharides	37-51	TIMP metallopeptidase inhibitor 3	Rattus norvegicus	162-169
24638056-2	2014	In order to understand cell proliferation and its association with COX-2 in HepG2 cells in the presence of ursolic acid (UA), viili exopolysaccharides (VEPS) and Astragalus polysaccharides (APS), the cell proliferation, superoxide dismutase (SOD) and metabolic malondialdehyde (MDA) of fatty acids, COX-2, prostaglandin E2 (PGE2), as well as apoptotic morphology and rate were investigated.	Polysaccharides	135-150	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72
24878505-4	2014	ST3Gal III transfected Capan-1 cells exhibited higher SLe(x) and lower alpha2,6-sialic acid content on the glycans of their alpha2beta1 integrin molecules.	Polysaccharides	107-114	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	0-10
24878505-8	2014	In conclusion, changes in the sialylation pattern of alpha2beta1 integrin and E-cadherin appear to influence the functional role of these two glycoproteins supporting the role of these glycans as an underlying mechanism regulating pancreatic cancer cell adhesion and invasion.	Polysaccharides	185-192	cadherin 1	Homo sapiens	78-88
24681444-5	2014	We explored the conformations and dynamics of the polysaccharide repeating units from serotypes 19F and 19A, comparing free energy surfaces for glycosidic linkages with 100ns aqueous molecular dynamics simulations of the di- and trisaccharide components.	Polysaccharides	50-64	SLAM family member 7	Homo sapiens	104-107
24681444-8	2014	This suggests a probable conformational difference between the 19F and 19A polysaccharides, which may explain the low cross-protection of 19F vaccines against 19A disease.	Polysaccharides	75-90	SLAM family member 7	Homo sapiens	71-74
24681444-8	2014	This suggests a probable conformational difference between the 19F and 19A polysaccharides, which may explain the low cross-protection of 19F vaccines against 19A disease.	Polysaccharides	75-90	SLAM family member 7	Homo sapiens	159-162
24423494-2	2014	The WVP of SPI/La/polysaccharide films decreased when polysaccharides were added using the co-drying process, regardless of the type of polysaccharide.	Polysaccharides	54-69	chromogranin A	Homo sapiens	11-14
24719335-7	2014	In addition, using pharmacological and genetic approaches, we demonstrate that glucosidase II (GII) mediates glycan trimming of TRPP2.	Polysaccharides	109-115	polycystin 2, transient receptor potential cation channel	Mus musculus	128-133
24719335-10	2014	These results highlight the biological importance of N-linked glycosylation and GII-mediated glycan trimming in the control of biogenesis and stability of TRPP2.	Polysaccharides	93-99	polycystin 2, transient receptor potential cation channel	Mus musculus	155-160
24803430-3	2014	We have modified the ligand-binding region (EGF domains 11-13) of human Notch1 (hN1) with O-fucose and O-glucose glycans and shown by flow cytometry and surface plasmon resonance that the Fringe-catalyzed addition of GlcNAc to the O-fucose at T466 in EGF12 substantially increases binding to Jagged1 and Delta-like 1 (DLL1) ligands.	Polysaccharides	113-120	notch receptor 1	Homo sapiens	72-78
24803430-3	2014	We have modified the ligand-binding region (EGF domains 11-13) of human Notch1 (hN1) with O-fucose and O-glucose glycans and shown by flow cytometry and surface plasmon resonance that the Fringe-catalyzed addition of GlcNAc to the O-fucose at T466 in EGF12 substantially increases binding to Jagged1 and Delta-like 1 (DLL1) ligands.	Polysaccharides	113-120	Jupiter microtubule associated homolog 1	Homo sapiens	80-83
24183980-0	2014	Comment on "pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19(+)CD20(+)CD3(-)CD70(-)CD27(+)IgM(+)CD43(+)CD5(+/-)".	Polysaccharides	25-39	CD19 molecule	Homo sapiens	129-133
24183980-0	2014	Comment on "pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19(+)CD20(+)CD3(-)CD70(-)CD27(+)IgM(+)CD43(+)CD5(+/-)".	Polysaccharides	25-39	keratin 20	Homo sapiens	136-140
24183980-0	2014	Comment on "pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19(+)CD20(+)CD3(-)CD70(-)CD27(+)IgM(+)CD43(+)CD5(+/-)".	Polysaccharides	25-39	CD70 molecule	Homo sapiens	149-153
24183980-0	2014	Comment on "pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19(+)CD20(+)CD3(-)CD70(-)CD27(+)IgM(+)CD43(+)CD5(+/-)".	Polysaccharides	25-39	CD27 molecule	Homo sapiens	156-160
24183980-0	2014	Comment on "pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19(+)CD20(+)CD3(-)CD70(-)CD27(+)IgM(+)CD43(+)CD5(+/-)".	Polysaccharides	25-39	sialophorin	Homo sapiens	169-173
24423494-2	2014	The WVP of SPI/La/polysaccharide films decreased when polysaccharides were added using the co-drying process, regardless of the type of polysaccharide.	Polysaccharides	54-68	chromogranin A	Homo sapiens	11-14
24423494-3	2014	The tensile strength of SPI/La film was increased by the addition of polysaccharides, and the percentage elongation at break was increased by incorporating PGA using the co-drying process.	Polysaccharides	69-84	chromogranin A	Homo sapiens	24-27
24670657-5	2014	Cell walls of rescued med5a/5b ref8 plants instead contain a novel lignin consisting almost exclusively of p-hydroxyphenyl lignin subunits, and moreover exhibit substantially facilitated polysaccharide saccharification.	Polysaccharides	187-201	cytochrome P450, family 98, subfamily A, polypeptide 3	Arabidopsis thaliana	31-35
24831810-4	2014	Accordingly, a series of in vitro assays conducted with purified Agl11-Agl14 showed these proteins to catalyze the stepwise conversion of glucose-1-phosphate to dTDP-rhamnose, the final sugar of the tetrasaccharide glycan.	Polysaccharides	215-221	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	161-165
24746277-3	2014	Neurons engineered to display CS-E-enriched polysaccharides exhibited increased activation of neurotrophin-mediated signaling pathways and enhanced axonal growth.	Polysaccharides	44-59	brain derived neurotrophic factor	Homo sapiens	94-106
24828077-0	2014	Promiscuous glycan site recognition by antibodies to the high-mannose patch of gp120 broadens neutralization of HIV.	Polysaccharides	12-18	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	79-84
24886259-0	2014	Polysaccharides from Liriopes Radix ameliorate streptozotocin-induced type I diabetic nephropathy via regulating NF-kappaB and p38 MAPK signaling pathways.	Polysaccharides	0-15	mitogen activated protein kinase 14	Rattus norvegicus	127-130
24692304-3	2014	We used glycosylated Ser-CCL1 that had been prepared by total chemical synthesis as a homogeneous compound containing an N-linked asialo biantennary nonasaccharide glycan moiety of defined covalent structure.	Polysaccharides	164-170	C-C motif chemokine ligand 1	Homo sapiens	25-29
24767986-5	2014	Rather than penetrating the glycan shield by using a single variable-region CDR loop, 8ANC195 inserted its entire heavy-chain variable domain into a gap to form a large interface with gp120 glycans and regions of the gp120 inner domain not contacted by other bNAbs.	Polysaccharides	190-197	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	184-189
24589677-0	2014	Galectin-1-mediated cell adhesion, invasion and cell death in human anaplastic large cell lymphoma: regulatory roles of cell surface glycans.	Polysaccharides	133-140	galectin 1	Homo sapiens	0-10
24561026-3	2014	Activated AT also inhibits thrombin by forming a stable ternary complex of AT, thrombin, and a polysaccharide (requires at least an 18-mer/octadeca-mer polysaccharide).	Polysaccharides	152-166	serpin family C member 1	Homo sapiens	10-12
24561026-3	2014	Activated AT also inhibits thrombin by forming a stable ternary complex of AT, thrombin, and a polysaccharide (requires at least an 18-mer/octadeca-mer polysaccharide).	Polysaccharides	152-166	coagulation factor II, thrombin	Homo sapiens	27-35
24561026-3	2014	Activated AT also inhibits thrombin by forming a stable ternary complex of AT, thrombin, and a polysaccharide (requires at least an 18-mer/octadeca-mer polysaccharide).	Polysaccharides	152-166	serpin family C member 1	Homo sapiens	75-77
24561026-3	2014	Activated AT also inhibits thrombin by forming a stable ternary complex of AT, thrombin, and a polysaccharide (requires at least an 18-mer/octadeca-mer polysaccharide).	Polysaccharides	95-109	serpin family C member 1	Homo sapiens	10-12
24561026-3	2014	Activated AT also inhibits thrombin by forming a stable ternary complex of AT, thrombin, and a polysaccharide (requires at least an 18-mer/octadeca-mer polysaccharide).	Polysaccharides	95-109	coagulation factor II, thrombin	Homo sapiens	27-35
24628331-8	2014	Furthermore, we demonstrate that our approach employing tandem mass tag (TMT) and target N-linked glycopeptides of VTN is a useful tool for quantifying specific glycans in HCC plasma relative to normal plasma.	Polysaccharides	161-168	vitronectin	Homo sapiens	115-118
24589677-5	2014	alpha2,6-linked sialic acid may be involved in masking the effect of the interaction between galectin-1 and cell surface glycans.	Polysaccharides	121-128	galectin 1	Homo sapiens	93-103
24941846-0	2014	[Astragalus polysaccharides improved the cardiac function in Sjogren"s syndrome model rats based on keap 1-Nrf2/ARE signaling pathway: a mechanism exploration].	Polysaccharides	12-27	Kelch-like ECH-associated protein 1	Rattus norvegicus	100-106
24687996-4	2014	The glycan effect on the protein fragmentation pattern was also investigated by comparing the fragmentation patterns of RNase B and its nonglycosylated analog RNase A.	Polysaccharides	4-10	ribonuclease A family member 1, pancreatic	Homo sapiens	159-166
24375254-0	2014	Astrocyte elevated gene-1 (AEG-1) shRNA sensitizes Huaier polysaccharide (HP)-induced anti-metastatic potency via inactivating downstream P13K/Akt pathway as well as augmenting cell-mediated immune response.	Polysaccharides	58-72	metadherin	Homo sapiens	0-25
24375254-0	2014	Astrocyte elevated gene-1 (AEG-1) shRNA sensitizes Huaier polysaccharide (HP)-induced anti-metastatic potency via inactivating downstream P13K/Akt pathway as well as augmenting cell-mediated immune response.	Polysaccharides	58-72	metadherin	Homo sapiens	27-32
24375254-0	2014	Astrocyte elevated gene-1 (AEG-1) shRNA sensitizes Huaier polysaccharide (HP)-induced anti-metastatic potency via inactivating downstream P13K/Akt pathway as well as augmenting cell-mediated immune response.	Polysaccharides	58-72	AKT serine/threonine kinase 1	Homo sapiens	143-146
24895481-0	2014	BRP, a polysaccharide fraction isolated from Boschniakia rossica, protects against galactosamine and lipopolysaccharide induced hepatic failure in mice.	Polysaccharides	7-21	growth differentiation factor 5	Mus musculus	0-3
24895481-1	2014	The aim of this study was to investigate the hepatoprotective effect of BRP, a polysaccharide fraction isolated from Boschniakia rossica, against galactosamine and lipopolysaccharide induced fulminant hepatic failure.	Polysaccharides	79-93	growth differentiation factor 5	Mus musculus	72-75
24677090-0	2014	Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP-2 and MMP-9 via downregulation of NF-kappaB signaling pathway.	Polysaccharides	0-14	matrix metallopeptidase 2	Mus musculus	102-107
24677090-0	2014	Polysaccharide from Inonotus obliquus inhibits migration and invasion in B16-F10 cells by suppressing MMP-2 and MMP-9 via downregulation of NF-kappaB signaling pathway.	Polysaccharides	0-14	matrix metallopeptidase 9	Mus musculus	112-117
25180871-7	2014	These data implied that changes in specific glycan structures, such as aFuc, GlcNAc, GalNAc, mannose, bisecting GlcNAc and terminal beta1-4 Gal, may be involved in PLC carcinogenesis .	Polysaccharides	44-50	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	132-139
24941846-0	2014	[Astragalus polysaccharides improved the cardiac function in Sjogren"s syndrome model rats based on keap 1-Nrf2/ARE signaling pathway: a mechanism exploration].	Polysaccharides	12-27	NFE2 like bZIP transcription factor 2	Rattus norvegicus	107-111
24623697-1	2014	RATIONALE: Glycan heterogeneity on recombinant human erythropoietin (rEPO) product is considered to be one of the critical quality attributes, and similarity tests of glycan heterogeneities are required in the manufacturing process changes and developments of biosimilars.	Polysaccharides	11-17	erythropoietin	Homo sapiens	53-67
24623697-1	2014	RATIONALE: Glycan heterogeneity on recombinant human erythropoietin (rEPO) product is considered to be one of the critical quality attributes, and similarity tests of glycan heterogeneities are required in the manufacturing process changes and developments of biosimilars.	Polysaccharides	11-17	erythropoietin	Rattus norvegicus	69-73
24623697-3	2014	METHODS: The glycan heterogeneities of nine rEPO products (four innovator products and five biosimilar products) were distinguished by multivariate analysis (MVA) using the peak area ratios of each glycan to the total peak area of glycans in mass spectra obtained by liquid chromatography/mass spectrometry (LC/MS) of N-glycans from rEPOs.	Polysaccharides	13-19	erythropoietin	Rattus norvegicus	44-48
24623697-5	2014	Using PC values as indices, we were able to visualize and digitalize the glycan heterogeneities of each rEPO.	Polysaccharides	73-79	erythropoietin	Rattus norvegicus	104-108
24623697-6	2014	The characteristic glycans of each rEPO were also successfully identified by orthogonal partial least-squares discrimination analysis (OPLS-DA), an MVA method, using the glycan profile data.	Polysaccharides	19-26	erythropoietin	Rattus norvegicus	35-39
24623697-6	2014	The characteristic glycans of each rEPO were also successfully identified by orthogonal partial least-squares discrimination analysis (OPLS-DA), an MVA method, using the glycan profile data.	Polysaccharides	19-25	erythropoietin	Rattus norvegicus	35-39
24752234-1	2014	The food-borne pathogen Listeria monocytogenes encodes two chitinases, ChiA and ChiB, which allow the bacterium to hydrolyze chitin, the second most abundant polysaccharide in nature.	Polysaccharides	158-172	chitinase acidic	Homo sapiens	71-75
24619407-8	2014	We show that levels of ManR and ASGR expression control the clearance rate for glycoproteins bearing recognized glycans.	Polysaccharides	112-119	asialoglycoprotein receptor 1	Mus musculus	32-36
24619415-0	2014	The absence of core fucose up-regulates GnT-III and Wnt target genes: a possible mechanism for an adaptive response in terms of glycan function.	Polysaccharides	128-134	mannoside acetylglucosaminyltransferase 3	Mus musculus	40-47
24627495-3	2014	The suspected role for the MAN1B1 gene product MAN1B1, also known as ER mannosidase I, is to function within the ER similar to the yeast ortholog Mns1p, which removes a terminal mannose unit to initiate a glycan-based ER-associated degradation (ERAD) signal.	Polysaccharides	205-211	mannosidase alpha class 1B member 1	Homo sapiens	27-33
24627495-3	2014	The suspected role for the MAN1B1 gene product MAN1B1, also known as ER mannosidase I, is to function within the ER similar to the yeast ortholog Mns1p, which removes a terminal mannose unit to initiate a glycan-based ER-associated degradation (ERAD) signal.	Polysaccharides	205-211	mannosidase alpha class 1B member 1	Homo sapiens	47-53
24627495-3	2014	The suspected role for the MAN1B1 gene product MAN1B1, also known as ER mannosidase I, is to function within the ER similar to the yeast ortholog Mns1p, which removes a terminal mannose unit to initiate a glycan-based ER-associated degradation (ERAD) signal.	Polysaccharides	205-211	mannosyl-oligosaccharide 1,2-alpha-mannosidase	Saccharomyces cerevisiae S288C	146-151
24619419-5	2014	Unexpectedly, these vesicles were also positive for galectin 3, suggesting that they were damaged and the membrane glycans became accessible to galectins to bind.	Polysaccharides	115-122	galectin 3	Homo sapiens	52-62
24645849-4	2014	This is comparable to the strength of the natural 2G12-gp120 interaction, and is the strongest affinity achieved to date with constructs containing 3-5 glycans.	Polysaccharides	152-159	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	55-60
24326249-4	2014	Key structural features revealed include galectin-3"s demonstration of a binding mode towards gangliosides distinct from that to the lacto/neolacto-glycosphingolipids, with its capacity for recognising the core beta-galactoside region being challenged when the core oligosaccharide epitope of ganglio-series glycosphingolipids (GM3) is embedded within particular higher-molecular-weight glycans.	Polysaccharides	387-394	galectin 3	Homo sapiens	41-51
24705413-0	2014	The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes.	Polysaccharides	28-43	interleukin 1 receptor antagonist	Mus musculus	158-164
25371572-4	2014	Polysaccharides from Gynostemma pentaphyllum (PGP), has been identified as one of the active ingredients responsible for its biological activities.	Polysaccharides	0-15	phosphoglycolate phosphatase	Rattus norvegicus	46-49
25371572-6	2014	The purpose of this study was to investigate the effects of polysaccharides from PGP on physical fatigue.	Polysaccharides	60-75	phosphoglycolate phosphatase	Rattus norvegicus	81-84
24616167-6	2014	Glycan arrays, including N-glycan structures with terminal Le(X) , were prepared by enzymatic extension of immobilized synthetic core structures with two recombinant glycosyltransferases.	Polysaccharides	0-6	fucosyltransferase 4	Mus musculus	59-64
24415556-3	2014	UGGT1 is a well-documented enzyme which functions as a folding sensor in the endoplasmic reticulum, by the virtue of its ability to transfer a glucose residue to non-glucosylated high-mannose-type glycans of immature glycoproteins exhibiting non-native conformation.	Polysaccharides	197-204	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	0-5
24447978-0	2014	TOP 1 and 2, polysaccharides from Taraxacum officinale, inhibit NFkappaB-mediated inflammation and accelerate Nrf2-induced antioxidative potential through the modulation of PI3K-Akt signaling pathway in RAW 264.7 cells.	Polysaccharides	13-28	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	64-72
24447978-0	2014	TOP 1 and 2, polysaccharides from Taraxacum officinale, inhibit NFkappaB-mediated inflammation and accelerate Nrf2-induced antioxidative potential through the modulation of PI3K-Akt signaling pathway in RAW 264.7 cells.	Polysaccharides	13-28	nuclear factor, erythroid derived 2, like 2	Mus musculus	110-114
24447978-0	2014	TOP 1 and 2, polysaccharides from Taraxacum officinale, inhibit NFkappaB-mediated inflammation and accelerate Nrf2-induced antioxidative potential through the modulation of PI3K-Akt signaling pathway in RAW 264.7 cells.	Polysaccharides	13-28	thymoma viral proto-oncogene 1	Mus musculus	178-181
24658681-4	2014	One approach to broaden the conjugate vaccine coverage could be the conjugation of the polysaccharide to a pneumococcal protein such as PspA.	Polysaccharides	87-101	surfactant protein A1	Rattus norvegicus	136-140
24385226-13	2014	These results suggest a role for ABO glycans and glycosyltransferases in ARDS susceptibility.	Polysaccharides	37-44	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	33-36
24415556-5	2014	This study aimed to reveal the property of human UGGT2 by using synthetic substrates such as fluorescently labeled glycans and N-glycosylated proteins.	Polysaccharides	115-122	UDP-glucose glycoprotein glucosyltransferase 2	Homo sapiens	49-54
24415556-6	2014	The analysis, for the first time, revealed the glucosyltransferase activity of UGGT2, whose specificity was shown to be quite similar to UGGT1, in terms of both glycan specificity and preferential recognition of proteins having non-native conformations.	Polysaccharides	161-167	UDP-glucose glycoprotein glucosyltransferase 2	Homo sapiens	79-84
24415556-6	2014	The analysis, for the first time, revealed the glucosyltransferase activity of UGGT2, whose specificity was shown to be quite similar to UGGT1, in terms of both glycan specificity and preferential recognition of proteins having non-native conformations.	Polysaccharides	161-167	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	137-142
24508920-0	2014	In vitro and in vivo antioxidant activity of a fructan from the roots of Arctium lappa L. To explore new antioxidant resource from food, a water-soluble polysaccharide (ALP1) was extracted and purified from the roots of Arctium lappa L. (A. lappa L.) through hot water extraction followed by ethanol precipitation, ion-exchange chromatography and gel filtration.	Polysaccharides	153-167	asparaginase like 1	Mus musculus	169-173
24418339-0	2014	Novel polysaccharide from Radix Cyathulae officinalis Kuan can improve immune response to ovalbumin in mice.	Polysaccharides	6-20	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	90-99
24737672-3	2014	Here, we investigated the role of Arabidopsis thaliana class I alpha-mannosidases (MNS1 to MNS5) in glycan-dependent ERAD.	Polysaccharides	100-106	alpha-mannosidase 1	Arabidopsis thaliana	83-87
23581857-3	2014	In this work, we have investigated ARSA dynamics employing molecular dynamics simulations in response to (1) different pH"s, as, beyond its natural lysossomal environment, it has been recently identified in cytoplasmatic medium and (2) glycan occupancies, including its normal glycosylation state, presenting three high mannose-type oligosaccharides.	Polysaccharides	236-242	arylsulfatase A	Homo sapiens	35-39
24105809-9	2014	In support of this, beta3GnT2 and GCNT2 co-transfection in HEK293T cells results in high levels of PLN expression on the cell surface and on adenylyl cyclase 3, a major carrier of PLN glycans in the OE.	Polysaccharides	184-191	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	20-29
24105809-9	2014	In support of this, beta3GnT2 and GCNT2 co-transfection in HEK293T cells results in high levels of PLN expression on the cell surface and on adenylyl cyclase 3, a major carrier of PLN glycans in the OE.	Polysaccharides	184-191	glucosaminyl (N-acetyl) transferase 2 (I blood group)	Homo sapiens	34-39
24343997-9	2014	Overall, our results suggest that UGE4 activity in d-galactose synthesis is required for the structure of cell wall polysaccharides and endomembrane organization.	Polysaccharides	116-131	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	34-38
24737672-3	2014	Here, we investigated the role of Arabidopsis thaliana class I alpha-mannosidases (MNS1 to MNS5) in glycan-dependent ERAD.	Polysaccharides	100-106	Glycosyl hydrolase family 47 protein	Arabidopsis thaliana	91-95
24651839-6	2014	Glycan profiling of IgA1 by the lectin microarray revealed an intense signal for Wisteria floribunda agglutinin (WFA).	Polysaccharides	0-6	immunoglobulin heavy constant alpha 1	Homo sapiens	20-24
24635768-3	2014	The results revealed that KCG and LBG at 0.5-1.0% could respectively cause significant increases of both WHC and hardness of corresponding heat-induced myosin-polysaccharide gels (P &lt; 0.05).	Polysaccharides	159-173	myosin, heavy chain 15	Gallus gallus	152-158
24664110-0	2014	The pneumococcal polysaccharide capsule and pneumolysin differentially affect CXCL8 and IL-6 release from cells of the upper and lower respiratory tract.	Polysaccharides	17-31	C-X-C motif chemokine ligand 8	Homo sapiens	78-83
24664110-0	2014	The pneumococcal polysaccharide capsule and pneumolysin differentially affect CXCL8 and IL-6 release from cells of the upper and lower respiratory tract.	Polysaccharides	17-31	interleukin 6	Homo sapiens	88-92
24125569-4	2014	Polysaccharides capable of reducing cellular senescence and modulating life span via telomere and insulin pathways have also been found to have the potential to inhibit protein aggregation and aggregation-associated neurodegeneration.	Polysaccharides	0-15	insulin	Homo sapiens	98-105
24691064-3	2014	Polysaccharides from fresh and dried litchi pulp (denoted as LPF and LPD, respectively) were isolated, investigated by GC-MS, GPC and UV/IR spectrum analysis and their antitumor and immunomodulatory activities were evaluated in vitro.	Polysaccharides	0-15	acyl-CoA synthetase bubblegum family member 1	Homo sapiens	69-72
24667709-1	2014	Many pathogens produce the beta-(1-6)-linked poly-N-acetylglucosamine (PNAG) surface polysaccharide that is being developed as a broadly protective antimicrobial vaccine.	Polysaccharides	85-99	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	27-36
24651839-10	2014	Our results of analysis in the rare case of a patient with monoclonal immunoglobulin deposition disease suggest that the formation of unusually polymerized IgA1 is caused by divergent mechanisms including multiple structural alterations of glycans, which contributes to IgA1 deposition and mesangium proliferation.	Polysaccharides	240-247	immunoglobulin heavy constant alpha 1	Homo sapiens	156-160
24651839-10	2014	Our results of analysis in the rare case of a patient with monoclonal immunoglobulin deposition disease suggest that the formation of unusually polymerized IgA1 is caused by divergent mechanisms including multiple structural alterations of glycans, which contributes to IgA1 deposition and mesangium proliferation.	Polysaccharides	240-247	immunoglobulin heavy constant alpha 1	Homo sapiens	270-274
24651839-7	2014	This signal was reduced by disrupting the native conformation of IgA1, suggesting that the distinct glycan profile was reflecting the conformational alteration of IgA1, including the glycan conformation detected as additional N-glycans on both the heavy and light chains.	Polysaccharides	100-106	immunoglobulin heavy constant alpha 1	Homo sapiens	65-69
24593132-0	2014	A Polysaccharide isolated from the liquid culture of Lentinus edodes (Shiitake) mushroom mycelia containing black rice bran protects mice against salmonellosis through upregulation of the Th1 immune reaction.	Polysaccharides	2-16	negative elongation factor complex member C/D, Th1l	Mus musculus	188-191
24651839-7	2014	This signal was reduced by disrupting the native conformation of IgA1, suggesting that the distinct glycan profile was reflecting the conformational alteration of IgA1, including the glycan conformation detected as additional N-glycans on both the heavy and light chains.	Polysaccharides	100-106	immunoglobulin heavy constant alpha 1	Homo sapiens	163-167
24651839-7	2014	This signal was reduced by disrupting the native conformation of IgA1, suggesting that the distinct glycan profile was reflecting the conformational alteration of IgA1, including the glycan conformation detected as additional N-glycans on both the heavy and light chains.	Polysaccharides	183-189	immunoglobulin heavy constant alpha 1	Homo sapiens	65-69
24651839-7	2014	This signal was reduced by disrupting the native conformation of IgA1, suggesting that the distinct glycan profile was reflecting the conformational alteration of IgA1, including the glycan conformation detected as additional N-glycans on both the heavy and light chains.	Polysaccharides	183-189	immunoglobulin heavy constant alpha 1	Homo sapiens	163-167
24630721-1	2014	The hexosamine biosynthetic pathway (HBP) generates uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) protein modifications.	Polysaccharides	109-115	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	97-103
24459148-1	2014	Fut7 encodes an alpha1,3-fucosyltransferase critical for biosynthesis of glycan ligands for all three selectins.	Polysaccharides	73-79	fucosyltransferase 7	Mus musculus	0-4
24723981-3	2014	In the present study, we present an innovative SPECT diagnostic tool for abdominal aortic aneurysm (AAA) produced from injectable polysaccharide microparticles radiolabeled with technetium 99m ((99m)Tc) and functionalized with fucoidan, a sulfated polysaccharide with the ability to target P-Selectin.	Polysaccharides	130-144	selectin P	Rattus norvegicus	290-300
24723981-11	2014	Histological studies revealed that functionalized radiolabeled polysaccharide microparticles were localized in the AAA wall, in the same location where P-Selectin was expressed.	Polysaccharides	63-77	selectin P	Rattus norvegicus	152-162
24459148-1	2014	Fut7 encodes an alpha1,3-fucosyltransferase critical for biosynthesis of glycan ligands for all three selectins.	Polysaccharides	73-79	fucosyltransferase 4	Mus musculus	16-43
24527664-8	2014	Similarly altered glycosylation profiles were observed for the individual proteins IgG, with a decrease of digalactosylated biantennary glycans after delivery, and alpha1-antitrypsin, on which increased levels of triantennary glycans were observed during pregnancy.	Polysaccharides	226-233	serpin family A member 1	Homo sapiens	164-182
24422531-0	2014	Application of a glycoproteomics-based biomarker development method: alteration in glycan structure on colony stimulating factor 1 receptor as a possible glycobiomarker candidate for evaluation of liver cirrhosis.	Polysaccharides	83-89	colony stimulating factor 1 receptor	Homo sapiens	103-139
24373178-6	2014	The binding of full-length MUB was confined to mucus via multiple interactions involving terminal sialylated mucin glycans.	Polysaccharides	115-122	ubiquitin like 3	Homo sapiens	27-30
24608122-7	2014	Glycans of hLF influence the binding to E. faecalis, and EndoE-hydrolyzed hLF inhibits biofilm formation to lesser extent than intact hLF indicating that EndoE prevents the inhibition of biofilm.	Polysaccharides	0-7	HLF transcription factor, PAR bZIP family member	Homo sapiens	11-14
24131788-3	2014	A molecular switch, MBP317-347, originally designed to be a high-affinity switch for maltose and maltose-like polysaccharides, was demonstrated to be a low-affinity switch for glucose, that is, able to be activated by high concentrations (tens of millimolar) of glucose.	Polysaccharides	110-125	myelin basic protein	Homo sapiens	20-23
24528726-2	2014	In order to explore the immunomodulatory effect of Houttuynia cordata Thunb., the water extract was studied and a polysaccharide HCP-2 with molecular weight of 60,000 Da was isolated by chromatography using DEAE Sepharose CL-6B and Sephacryl S-500 [corrected] HR columns.	Polysaccharides	114-128	CYCS pseudogene 52	Homo sapiens	129-134
24528726-4	2014	HCP-2 was elucidated as a pectic polysaccharide with a linear chain of 1,4-linked alpha-D-galacturonic acid residues in which part of the 6-carboxyl groups were methyl esterified and part of 2-hydroxyl groups were acetylated.	Polysaccharides	33-47	CYCS pseudogene 52	Homo sapiens	0-5
24239607-5	2014	Our results clearly demonstrate that DC-SIGN has a broader glycan specificity compared to DCIR, which interacts only with mannotriose, sulfo-Lewis(a), Lewis(b) and Lewis(a).	Polysaccharides	59-65	CD209 molecule	Homo sapiens	37-44
24310166-3	2014	Our previous findings suggest that complex-type N-glycans on the class II major histocompatibility complex play an important role in antigen selection within antigen presenting cells (APCs) such that highly branched N-glycans promote polysaccharide (glycoantigen, GlyAg) presentation following Toll-like receptor 2 (TLR2)-dependent antigen processing.	Polysaccharides	234-248	toll-like receptor 2	Mus musculus	294-314
24310166-3	2014	Our previous findings suggest that complex-type N-glycans on the class II major histocompatibility complex play an important role in antigen selection within antigen presenting cells (APCs) such that highly branched N-glycans promote polysaccharide (glycoantigen, GlyAg) presentation following Toll-like receptor 2 (TLR2)-dependent antigen processing.	Polysaccharides	234-248	toll-like receptor 2	Mus musculus	316-320
24239607-2	2014	Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is one of the best-studied C-type lectin receptors expressed on DCs and its glycan specificity and functional requirements for ligand binding have been intensively investigated.	Polysaccharides	166-172	CD209 molecule	Homo sapiens	0-79
24239607-2	2014	Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is one of the best-studied C-type lectin receptors expressed on DCs and its glycan specificity and functional requirements for ligand binding have been intensively investigated.	Polysaccharides	166-172	CD209 molecule	Homo sapiens	81-88
24336949-4	2014	Blocking the addition of NLGs or inhibiting initial glycan processing prevented the secretion of BMP-2.	Polysaccharides	52-58	bone morphogenetic protein 2	Homo sapiens	97-102
24352591-2	2014	Although whole/core glycan structures and carrier glycoproteins for the N-linked HNK-1 epitope have been studied, carrier glycoproteins and the biosynthetic pathway of the O-mannose-linked HNK-1 epitope have not been fully characterized.	Polysaccharides	20-26	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	81-86
24352591-4	2014	The O-linked HNK-1 epitope on phosphacan almost disappeared due to the knockout of protein O-mannose beta1,2-N-acetylglucosaminyltransferase 1, an N-acetylglucosaminyltransferase essential for O-mannose-linked glycan synthesis, indicating that the reducing terminal of the O-linked HNK-1 is mannose.	Polysaccharides	210-216	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	13-18
24262656-0	2014	Gene cloning and characterization of an alpha-amylase from Alteromonas macleodii B7 for Enteromorpha polysaccharide degradation.	Polysaccharides	101-115	alpha-amylase	Alteromonas macleodii ATCC 27126	40-53
24462389-3	2014	In this study, we reported that the activity of the polysaccharide LBPF4-OL, which was purified from LBP, is closely associated with the TLR4-MAPK signaling pathway.	Polysaccharides	52-66	toll-like receptor 4	Mus musculus	137-141
24366413-1	2014	BACKGROUND: O-linked beta-N-acetylglucosamine (O-GlcNAc) is a glycan essential for fundamental cellular processes such as transcription/translation, nuclear transport, protein stability and protein-protein interactions.	Polysaccharides	62-68	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	47-55
24558470-1	2014	Blood group-related glycans determining ABO and Lewis blood groups are known to function as attachment factors for most of the norovirus (NoV) strains.	Polysaccharides	20-27	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	40-43
24471993-3	2014	For this purpose, the polysaccharide was dissolved in an ionic liquid, 1-buthyl-3-methylimidazolium chloride (BMImCl), and dropped on the top of the hybrid cellulase-ADH-DPPC LB film.	Polysaccharides	22-36	aldo-keto reductase family 1 member A1	Homo sapiens	166-169
24398680-2	2014	These immunodeposits originate from circulating immune complexes consisting of anti-glycan antibodies bound to Gd-IgA1.	Polysaccharides	84-90	immunoglobulin heavy constant alpha 1	Homo sapiens	114-118
24649404-0	2014	Ursolic acid, a natural pentacyclic triterpenoid, inhibits intracellular trafficking of proteins and induces accumulation of intercellular adhesion molecule-1 linked to high-mannose-type glycans in the endoplasmic reticulum.	Polysaccharides	187-194	intercellular adhesion molecule 1	Homo sapiens	125-158
24649404-7	2014	Ursolic acid induced the accumulation of ICAM-1 in the endoplasmic reticulum, which was linked mainly to high-mannose-type glycans.	Polysaccharides	123-130	intercellular adhesion molecule 1	Homo sapiens	41-47
24649404-9	2014	Thus, our results reveal that ursolic acid inhibits intracellular trafficking of proteins and induces the accumulation of ICAM-1 linked to high-mannose-type glycans in the endoplasmic reticulum.	Polysaccharides	157-164	intercellular adhesion molecule 1	Homo sapiens	122-128
24389593-1	2014	Our primary objective was to determine whether administering the viscous and fermentable polysaccharide PolyGlycopleX (PGX) with metformin (MET) or sitagliptin/metformin (S/MET) reduces hyperglycemia in Zucker diabetic fatty (ZDF) rats more so than monotherapy of each.	Polysaccharides	89-103	MET proto-oncogene, receptor tyrosine kinase	Rattus norvegicus	140-143
24507317-3	2014	One major fraction (LBP-1) was obtained by purifying the crude polysaccharides extracted from Lilii Bulbus.	Polysaccharides	63-78	transcription factor CP2	Mus musculus	20-25
24328305-10	2014	However, a significant increase in both outer arm (alpha1-3) (p = 0.04) and core (alpha1-6) fucosylated glycans (p &lt; 0.0001) was found on Z-AAT compared to M-AAT.	Polysaccharides	104-111	adrenoceptor alpha 1D	Homo sapiens	82-90
24328305-10	2014	However, a significant increase in both outer arm (alpha1-3) (p = 0.04) and core (alpha1-6) fucosylated glycans (p &lt; 0.0001) was found on Z-AAT compared to M-AAT.	Polysaccharides	104-111	serpin family A member 1	Homo sapiens	143-146
24393138-0	2014	Glycan analysis of Prostate Specific Antigen (PSA) directly from the intact glycoprotein by HR-ESI/TOF-MS. Glycans are important modulators of the biological function of proteins and are normally characterized from proteolytic glycopeptides or from (N-)glycans released enzymatically by glycosidase treatment or chemically by hydrazinolysis.	Polysaccharides	0-6	kallikrein related peptidase 3	Homo sapiens	19-44
24308486-9	2014	In contrast, myeloma IgE showed a higher abundance of triantennary and tetraantennary glycan structures and a low abundance of species with a bisecting N-acetylglucosamine.	Polysaccharides	86-92	immunoglobulin heavy constant epsilon	Homo sapiens	21-24
24393138-0	2014	Glycan analysis of Prostate Specific Antigen (PSA) directly from the intact glycoprotein by HR-ESI/TOF-MS. Glycans are important modulators of the biological function of proteins and are normally characterized from proteolytic glycopeptides or from (N-)glycans released enzymatically by glycosidase treatment or chemically by hydrazinolysis.	Polysaccharides	0-6	kallikrein related peptidase 3	Homo sapiens	46-49
24499211-9	2014	Mass spectrometry of transferrin showed a loss of complete N-glycans and the presence of truncated glycans lacking galactose.	Polysaccharides	61-68	transferrin	Homo sapiens	21-32
24393138-0	2014	Glycan analysis of Prostate Specific Antigen (PSA) directly from the intact glycoprotein by HR-ESI/TOF-MS. Glycans are important modulators of the biological function of proteins and are normally characterized from proteolytic glycopeptides or from (N-)glycans released enzymatically by glycosidase treatment or chemically by hydrazinolysis.	Polysaccharides	107-114	kallikrein related peptidase 3	Homo sapiens	19-44
24393138-0	2014	Glycan analysis of Prostate Specific Antigen (PSA) directly from the intact glycoprotein by HR-ESI/TOF-MS. Glycans are important modulators of the biological function of proteins and are normally characterized from proteolytic glycopeptides or from (N-)glycans released enzymatically by glycosidase treatment or chemically by hydrazinolysis.	Polysaccharides	107-114	kallikrein related peptidase 3	Homo sapiens	46-49
24393138-2	2014	Interpretation of isotopically resolved mass spectra of prostate specific antigen (PSA) using bioinformatics tools gives within a few hours the glycan compositions of 38 glycoforms.	Polysaccharides	144-150	kallikrein related peptidase 3	Homo sapiens	56-81
24393138-2	2014	Interpretation of isotopically resolved mass spectra of prostate specific antigen (PSA) using bioinformatics tools gives within a few hours the glycan compositions of 38 glycoforms.	Polysaccharides	144-150	kallikrein related peptidase 3	Homo sapiens	83-86
24328305-6	2014	In this study, we investigate whether the glycans present on Z-AAT differ to those found on M-AAT from healthy controls.	Polysaccharides	42-49	serpin family A member 1	Homo sapiens	63-66
24327294-5	2014	In this study, we built a three-dimensional (3D) model of glycosylated human BChE to investigate the influence of glycans on the PEGylation modification.	Polysaccharides	114-121	butyrylcholinesterase	Homo sapiens	77-81
24486647-5	2014	Recent developments in glycan microarray technology revolutionized analysis of GBP glycan interactions with significant implications in understanding the role of GBPs in host immunity.	Polysaccharides	23-29	transmembrane protein 132A	Homo sapiens	79-82
24486647-5	2014	Recent developments in glycan microarray technology revolutionized analysis of GBP glycan interactions with significant implications in understanding the role of GBPs in host immunity.	Polysaccharides	83-89	transmembrane protein 132A	Homo sapiens	79-82
24424878-6	2014	Enzymes able to generate intra- and intermolecular crosslinks between proteins and/or polysaccharides will be reviewed and specific reactions catalyzed by, e.g., transglutaminase, laccase, tyrosinase, sulfhydryl oxidase, glucose oxidase, lipoxygenase, polyphenol oxidase, peroxidase, and lysyl oxidase will be highlighted.	Polysaccharides	86-101	tyrosinase	Homo sapiens	189-199
24316254-1	2014	In this study, we investigated the effect of a polysaccharide purified from the seeds of Plantago asiatica L. (PLP-2) on the phenotypic and functional maturation of murine bone marrow-derived dendritic cells (DCs) and relevant mechanisms.	Polysaccharides	47-61	proteolipid protein 2	Mus musculus	111-116
24516685-4	2014	METHODOLOGY: Here we report the evaluation in mice of a conjugate vaccine for cholera (OSP:TThc) made from V. cholerae O1 Ogawa O-Specific Polysaccharide-core (OSP) and recombinant tetanus toxoid heavy chain fragment (TThc).	Polysaccharides	139-153	claudin 11	Mus musculus	87-90
24516685-4	2014	METHODOLOGY: Here we report the evaluation in mice of a conjugate vaccine for cholera (OSP:TThc) made from V. cholerae O1 Ogawa O-Specific Polysaccharide-core (OSP) and recombinant tetanus toxoid heavy chain fragment (TThc).	Polysaccharides	139-153	claudin 11	Mus musculus	160-163
24498414-4	2014	In this study, we determined the crystal structure of ERGIC-53-CRD in complex with their binding partner, MCFD2 and the alpha1,2 mannotriose which corresponds to the trisaccharide of the D1 arm of high-mannose-type glycans.	Polysaccharides	215-222	lectin, mannose binding 1	Homo sapiens	54-62
24498414-4	2014	In this study, we determined the crystal structure of ERGIC-53-CRD in complex with their binding partner, MCFD2 and the alpha1,2 mannotriose which corresponds to the trisaccharide of the D1 arm of high-mannose-type glycans.	Polysaccharides	215-222	multiple coagulation factor deficiency 2, ER cargo receptor complex subunit	Homo sapiens	106-111
24498414-4	2014	In this study, we determined the crystal structure of ERGIC-53-CRD in complex with their binding partner, MCFD2 and the alpha1,2 mannotriose which corresponds to the trisaccharide of the D1 arm of high-mannose-type glycans.	Polysaccharides	215-222	adrenoceptor alpha 1D	Homo sapiens	120-128
24090571-4	2014	Our observation that the LCCL-domains of CRISPLD2 are specific for the toxic lipid A moiety of the endotoxin suggests that it may block the interaction between endotoxins and the host endotoxin receptors without interfering with the development of antibacterial immunity against the polysaccharide moiety of LPS.	Polysaccharides	283-297	cysteine rich secretory protein LCCL domain containing 2	Homo sapiens	41-49
24778281-4	2014	Changes in glycan moieties contribute to MUC1 immunogenicity and can modify the interactions of tumor cells with antigen-presenting cells such as dendritic cells that would affect the overall antitumor immune response.	Polysaccharides	11-17	mucin 1, cell surface associated	Homo sapiens	41-45
24778281-6	2014	In fact, MUC1 carried by microvesicles translocates from the endolysosomal/HLA-II to the HLA-I compartment and is presented by dendritic cells to MUC1-specific CD8(+) T cells stimulating IFN-gamma responses, whereas the soluble MUC1 is retained in the endolysosomal/HLA-II compartment independently by the glycan moieties and by the modality of internalization (receptor-mediated or non-receptor mediated).	Polysaccharides	306-312	mucin 1, cell surface associated	Homo sapiens	9-13
24778281-6	2014	In fact, MUC1 carried by microvesicles translocates from the endolysosomal/HLA-II to the HLA-I compartment and is presented by dendritic cells to MUC1-specific CD8(+) T cells stimulating IFN-gamma responses, whereas the soluble MUC1 is retained in the endolysosomal/HLA-II compartment independently by the glycan moieties and by the modality of internalization (receptor-mediated or non-receptor mediated).	Polysaccharides	306-312	mucin 1, cell surface associated	Homo sapiens	146-150
24778281-6	2014	In fact, MUC1 carried by microvesicles translocates from the endolysosomal/HLA-II to the HLA-I compartment and is presented by dendritic cells to MUC1-specific CD8(+) T cells stimulating IFN-gamma responses, whereas the soluble MUC1 is retained in the endolysosomal/HLA-II compartment independently by the glycan moieties and by the modality of internalization (receptor-mediated or non-receptor mediated).	Polysaccharides	306-312	mucin 1, cell surface associated	Homo sapiens	146-150
24242364-6	2014	However, other studies demonstrated that the position of sulfate groups is also critical for high-affinity binding of the polysaccharides to fibronectin.	Polysaccharides	122-137	fibronectin 1	Homo sapiens	141-152
24299844-3	2014	Our results demonstrated that polysaccharides markedly promoted the cytotoxicity of NK cells by enhancing IFN-gamma and perforin secretion and increasing the expression of the activating receptor NKp30 under normal conditions.	Polysaccharides	30-45	interferon gamma	Homo sapiens	106-115
24684110-0	2014	[Effects of electroacupuncture intervention combined with polysaccharide of Gastrodia elata Blume on expression of nestin and cytokines of neural stem cells in the dentate gyrus of cerebral ischemia rats].	Polysaccharides	58-72	nestin	Rattus norvegicus	115-121
24731418-1	2014	OBJECTIVE: To compare the ability of the polysaccharide from various Porphyromonas gingivalis (Pg) type and clinical strains in inducing THP-1 cells to produce cytokines interleukin(IL)-1beta, IL-8, and tumor necrosis factor(TNF)-alpha, in order to analyze the immunogenicity of Pg polysaccharide components and the virulence-associated factors of this periodontal pathogen.	Polysaccharides	41-55	interleukin 1 beta	Homo sapiens	170-191
24731418-1	2014	OBJECTIVE: To compare the ability of the polysaccharide from various Porphyromonas gingivalis (Pg) type and clinical strains in inducing THP-1 cells to produce cytokines interleukin(IL)-1beta, IL-8, and tumor necrosis factor(TNF)-alpha, in order to analyze the immunogenicity of Pg polysaccharide components and the virulence-associated factors of this periodontal pathogen.	Polysaccharides	41-55	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
24731418-1	2014	OBJECTIVE: To compare the ability of the polysaccharide from various Porphyromonas gingivalis (Pg) type and clinical strains in inducing THP-1 cells to produce cytokines interleukin(IL)-1beta, IL-8, and tumor necrosis factor(TNF)-alpha, in order to analyze the immunogenicity of Pg polysaccharide components and the virulence-associated factors of this periodontal pathogen.	Polysaccharides	41-55	tumor necrosis factor	Homo sapiens	203-235
24731418-8	2014	CONCLUSIONS: Polysaccharide extracted from Pg could induced the THP-1 cells to secrete the cytokines of IL-1beta, IL-8 and TNF-alpha.	Polysaccharides	13-27	interleukin 1 beta	Homo sapiens	104-112
24731418-8	2014	CONCLUSIONS: Polysaccharide extracted from Pg could induced the THP-1 cells to secrete the cytokines of IL-1beta, IL-8 and TNF-alpha.	Polysaccharides	13-27	C-X-C motif chemokine ligand 8	Homo sapiens	114-118
24731418-8	2014	CONCLUSIONS: Polysaccharide extracted from Pg could induced the THP-1 cells to secrete the cytokines of IL-1beta, IL-8 and TNF-alpha.	Polysaccharides	13-27	tumor necrosis factor	Homo sapiens	123-132
24374641-3	2014	Overall, a simple route to achieve the biological relevant NAG-NAM is presented, which may serve as a conceptual framework in the designing of synthetic strategies of different natural and non-natural polysaccharides.	Polysaccharides	201-216	SH3 and cysteine rich domain 3	Homo sapiens	63-66
23917429-5	2014	This was confirmed with lectin affinity assays that revealed glycan attachment on the alpha1, alpha4, and beta1-3 GABAAR subunits.	Polysaccharides	61-67	adrenoceptor alpha 1D	Homo sapiens	86-100
23917429-5	2014	This was confirmed with lectin affinity assays that revealed glycan attachment on the alpha1, alpha4, and beta1-3 GABAAR subunits.	Polysaccharides	61-67	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	106-113
24047103-4	2014	Polysaccharides from Cordyceps sinensis (CSP) have been identified as active ingredients responsible for its biological activities.	Polysaccharides	0-15	DnaJ heat shock protein family (Hsp40) member C5	Mus musculus	41-44
24299844-3	2014	Our results demonstrated that polysaccharides markedly promoted the cytotoxicity of NK cells by enhancing IFN-gamma and perforin secretion and increasing the expression of the activating receptor NKp30 under normal conditions.	Polysaccharides	30-45	natural cytotoxicity triggering receptor 3	Homo sapiens	196-201
24299844-4	2014	Meanwhile polysaccharides can enhance NK cell function under SMG conditions by restoring the expression of the activating receptor NKG2D and reducing the early apoptosis and late apoptosis/necrosis.	Polysaccharides	10-25	killer cell lectin like receptor K1	Homo sapiens	131-136
24299844-5	2014	Moreover, the antibody neutralization test showed that CR3 may be the critical receptor involved in polysaccharides induced NK cells activation.	Polysaccharides	100-115	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	55-58
24473128-2	2014	The GP1 subunit contains two heavily glycosylated domains, the glycan cap and the mucin-like domain (MLD).	Polysaccharides	63-69	GTP binding protein 1	Mus musculus	4-7
24473128-11	2014	In total, our results provide evidence that the conserved N-linked glycans on the EBOV GP1 core protect GP from antibody neutralization despite the negative impact the glycans have on viral entry efficiency.	Polysaccharides	67-74	GTP binding protein 1	Mus musculus	87-90
24365146-7	2014	Thus p22(phox) directly contributes to Nox1 activation in a glycosylation-independent manner, besides its significant role in Nox1 glycan maturation.	Polysaccharides	131-137	calcineurin like EF-hand protein 1	Homo sapiens	5-8
24475039-2	2014	A novel polysaccharide (called SC-2) was isolated from SC of MW 841 kDa, which exhibited a protein-to-polysaccharide ratio of 0.4089, and showed a characteristic FTIR spectrum of a peptidoglycan.	Polysaccharides	8-22	trans-2,3-enoyl-CoA reductase	Homo sapiens	31-35
24475039-2	2014	A novel polysaccharide (called SC-2) was isolated from SC of MW 841 kDa, which exhibited a protein-to-polysaccharide ratio of 0.4089, and showed a characteristic FTIR spectrum of a peptidoglycan.	Polysaccharides	102-116	trans-2,3-enoyl-CoA reductase	Homo sapiens	31-35
24465697-2	2014	We report here the effects of the prebiotic polysaccharide inulin and its hydrolysed form FOS on this bacterium.	Polysaccharides	44-58	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	90-93
24054254-0	2014	Protective effects of Ziyang tea polysaccharides on CCl4-induced oxidative liver damage in mice.	Polysaccharides	33-48	chemokine (C-C motif) ligand 4	Mus musculus	52-56
24445261-0	2014	Re-evaluation of binding properties of recombinant lymphocyte receptors NKR-P1A and CD69 to chemically synthesized glycans and peptides.	Polysaccharides	115-122	killer cell lectin like receptor B1	Homo sapiens	72-79
24445261-0	2014	Re-evaluation of binding properties of recombinant lymphocyte receptors NKR-P1A and CD69 to chemically synthesized glycans and peptides.	Polysaccharides	115-122	CD69 molecule	Homo sapiens	84-88
24184502-12	2014	The data demonstrated that remodeling of glycans by GnT-III mediated bisect glycosylation, contributes to the membranous retention of E-cadherin by 5-ASA; facilitating intercellular adhesion.	Polysaccharides	41-48	mannoside acetylglucosaminyltransferase 3	Mus musculus	52-59
24184502-12	2014	The data demonstrated that remodeling of glycans by GnT-III mediated bisect glycosylation, contributes to the membranous retention of E-cadherin by 5-ASA; facilitating intercellular adhesion.	Polysaccharides	41-48	cadherin 1	Mus musculus	134-144
24054266-2	2014	To improve the stability of anthocyanins in neutral to weakly acidic pH region, effects of metal cations and polysaccharides on the colour stability of cyanidin-3-glucoside (C3G) were examined by ultraviolet-visible and resonance Raman spectroscopies.	Polysaccharides	109-124	Rap guanine nucleotide exchange factor 1	Homo sapiens	152-177
25151377-2	2014	Among brain-specific glycans in mammals, we focus on human natural killer-1 (HNK-1) and related Cat-315 epitopes, which can be detected using specific antibodies.	Polysaccharides	21-28	beta-1,3-glucuronyltransferase 1	Homo sapiens	77-82
25300539-5	2014	Recently, several marine polysaccharides such alginate, porphyran, fucoidan, and chitin and its derivatives have been found as modulators of allergic responses due to enhancing innate immune system, altering Th1/Th2 balance, inhibiting IgE production, and suppressing mast cell degranulation.	Polysaccharides	25-40	negative elongation factor complex member C/D	Homo sapiens	208-211
24558328-1	2014	Cellulose synthase-like (Csl) genes are believed to encode enzymes for the synthesis of cell wall matrix polysaccharides.	Polysaccharides	105-120	cellulose synthase like	Arabidopsis thaliana	0-23
24558328-1	2014	Cellulose synthase-like (Csl) genes are believed to encode enzymes for the synthesis of cell wall matrix polysaccharides.	Polysaccharides	105-120	cellulose synthase like	Arabidopsis thaliana	25-28
24252697-2	2014	Ganoderma formosanum is a native Ganoderma species isolated in Taiwan, and we have previously demonstrated that PS-F2, a polysaccharide fraction purified from the submerged culture broth of G. formosanum, exhibits immunostimulatory properties in macrophages.	Polysaccharides	121-135	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	112-117
24314667-2	2014	This is generally attributed to masking of sensitive epitopes by the V1/V2 domain and/or glycans situated at various positions in Env.	Polysaccharides	89-96	endogenous retrovirus group W member 1, envelope	Homo sapiens	130-133
24332541-7	2014	Cross-species gene addition experiments demonstrate that recipients can grow on a polysaccharide if the producer-derived glycoside hydrolase, responsible for PBP generation, is provided.	Polysaccharides	82-96	dedicator of cytokinesis 3	Homo sapiens	158-161
25151377-3	2014	It is known that the HNK-1 epitope is expressed on N- and O-mannosylated glycans and that Cat-315 mAb preferentially recognizes the HNK-1 epitope on brain-specific "branched O-mannose glycan."	Polysaccharides	73-80	beta-1,3-glucuronyltransferase 1	Homo sapiens	21-26
24377566-3	2014	We show here that Angelica sinensis polysaccharide (ASP), a major active component in Dong quai (Chinese Angelica sinensis), effectively inhibited human AML CD34+CD38?	Polysaccharides	36-50	CD34 molecule	Homo sapiens	157-161
24377566-3	2014	We show here that Angelica sinensis polysaccharide (ASP), a major active component in Dong quai (Chinese Angelica sinensis), effectively inhibited human AML CD34+CD38?	Polysaccharides	36-50	CD38 molecule	Homo sapiens	162-166
24274474-2	2014	The intended grafting of the PAM chains on polysaccharide backbone was confirmed through standard physicochemical characterization techniques, namely intrinsic viscosity measurement, Fourier transform infrared (FTIR) spectroscopy, elemental analysis (C, H, N and O), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM) studies.	Polysaccharides	43-57	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	29-32
25300119-3	2014	The recent data on the effect of the extracts and sulfated polysaccharides of seaweed on the functional activity of the liver with injuries induced by CCl4, some drugs (paracetamol, diclofenac), N-nitrosocompounds, aflatoxin are presented in the review.	Polysaccharides	59-74	C-C motif chemokine ligand 4	Homo sapiens	151-155
24274552-2	2014	Sulfated polysaccharides protected RAW264.7 cells from oxidative damage and apoptosis induced by H2O2 by protecting the cellular structure; improving the activity of antioxidant enzymes, such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px); and inhibiting caspase-3 activation and DNA fragmentation.	Polysaccharides	9-24	caspase 3	Mus musculus	274-283
24274507-0	2014	Purification of a fucoidan from kelp polysaccharide and its inhibitory kinetics for tyrosinase.	Polysaccharides	37-51	tyrosinase	Homo sapiens	84-94
24274568-2	2014	Two polysaccharides (PMP-1 and PMP-2) were identified as homogeneous in molecular weight with HPLC.	Polysaccharides	4-19	peripheral myelin protein 2	Rattus norvegicus	31-36
24274513-1	2014	In the present study, the extraction, purification and characterization of polysaccharides from Hawk mature leaf tea (HMP) were investigated.	Polysaccharides	75-90	inner membrane mitochondrial protein	Homo sapiens	118-121
24336744-0	2014	SGP-2, an acidic polysaccharide from Sarcandra glabra, inhibits proliferation and migration of human osteosarcoma cells.	Polysaccharides	17-31	clusterin	Homo sapiens	0-5
23723009-6	2014	Multiple molecular sites of ASICs are distinctly affected in T1D, probably due to particular steric constraints for glycans accessibility to the active site: (i) ASIC1 current inactivates faster, while ASIC2 is slower; (ii) PcTx1 partly reverts diabetes effects against ASIC1- and ASIC2-inactivations; (iii) APETx2 maintains unaltered potency against ASIC3 current amplitude, but slows ASIC3 inactivation.	Polysaccharides	116-123	acid-sensing (proton-gated) ion channel 1	Mus musculus	162-167
23723009-6	2014	Multiple molecular sites of ASICs are distinctly affected in T1D, probably due to particular steric constraints for glycans accessibility to the active site: (i) ASIC1 current inactivates faster, while ASIC2 is slower; (ii) PcTx1 partly reverts diabetes effects against ASIC1- and ASIC2-inactivations; (iii) APETx2 maintains unaltered potency against ASIC3 current amplitude, but slows ASIC3 inactivation.	Polysaccharides	116-123	acid-sensing (proton-gated) ion channel 2	Mus musculus	202-207
23723009-6	2014	Multiple molecular sites of ASICs are distinctly affected in T1D, probably due to particular steric constraints for glycans accessibility to the active site: (i) ASIC1 current inactivates faster, while ASIC2 is slower; (ii) PcTx1 partly reverts diabetes effects against ASIC1- and ASIC2-inactivations; (iii) APETx2 maintains unaltered potency against ASIC3 current amplitude, but slows ASIC3 inactivation.	Polysaccharides	116-123	acid-sensing (proton-gated) ion channel 1	Mus musculus	270-275
23723009-6	2014	Multiple molecular sites of ASICs are distinctly affected in T1D, probably due to particular steric constraints for glycans accessibility to the active site: (i) ASIC1 current inactivates faster, while ASIC2 is slower; (ii) PcTx1 partly reverts diabetes effects against ASIC1- and ASIC2-inactivations; (iii) APETx2 maintains unaltered potency against ASIC3 current amplitude, but slows ASIC3 inactivation.	Polysaccharides	116-123	acid-sensing (proton-gated) ion channel 3	Mus musculus	351-356
23723009-6	2014	Multiple molecular sites of ASICs are distinctly affected in T1D, probably due to particular steric constraints for glycans accessibility to the active site: (i) ASIC1 current inactivates faster, while ASIC2 is slower; (ii) PcTx1 partly reverts diabetes effects against ASIC1- and ASIC2-inactivations; (iii) APETx2 maintains unaltered potency against ASIC3 current amplitude, but slows ASIC3 inactivation.	Polysaccharides	116-123	acid-sensing (proton-gated) ion channel 3	Mus musculus	386-391
24014058-5	2014	Seventeen N-glycans, including 11 glycans (1 core structure and 10 complex-type oligosaccharides), that commonly exist in ovotransferrin and ovomucoid were identified.	Polysaccharides	12-19	transferrin (ovotransferrin)	Gallus gallus	122-136
24014058-5	2014	Seventeen N-glycans, including 11 glycans (1 core structure and 10 complex-type oligosaccharides), that commonly exist in ovotransferrin and ovomucoid were identified.	Polysaccharides	12-19	serine peptidase inhibitor, Kazal type 7 (putative)	Gallus gallus	141-150
24056723-4	2014	The preeminent technique for defining specificity is glycan array screening, in which a glycan-binding protein (GBP) can be simultaneously screened against multiple glycans.	Polysaccharides	53-59	transmembrane protein 132A	Homo sapiens	88-110
24056723-4	2014	The preeminent technique for defining specificity is glycan array screening, in which a glycan-binding protein (GBP) can be simultaneously screened against multiple glycans.	Polysaccharides	53-59	transmembrane protein 132A	Homo sapiens	112-115
24056723-4	2014	The preeminent technique for defining specificity is glycan array screening, in which a glycan-binding protein (GBP) can be simultaneously screened against multiple glycans.	Polysaccharides	165-172	transmembrane protein 132A	Homo sapiens	112-115
24056723-5	2014	Glycan array screening has provided unparalleled insight into GBP specificity, but data interpretation suffers from difficulties in identifying false-negative binding arising from altered glycan presentation, associated with the linker used to conjugate the glycan to the surface.	Polysaccharides	0-6	transmembrane protein 132A	Homo sapiens	62-65
24654772-2	2014	The purified polysaccharide AP1-1 was obtained from PE by macroporous adsorption resin chromatography, DEAE cellulose chromatography, and Sephadex gel chromatography; the homogeneity and the molecular weight of AP1-1 were determined by gel filtration; and the acid hydrolysis, periodate oxidation, Smith degradation, and NMR analysis were used to analyze the chemical structure of AP1-1.	Polysaccharides	13-27	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-33
24654772-2	2014	The purified polysaccharide AP1-1 was obtained from PE by macroporous adsorption resin chromatography, DEAE cellulose chromatography, and Sephadex gel chromatography; the homogeneity and the molecular weight of AP1-1 were determined by gel filtration; and the acid hydrolysis, periodate oxidation, Smith degradation, and NMR analysis were used to analyze the chemical structure of AP1-1.	Polysaccharides	13-27	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	211-216
24654772-2	2014	The purified polysaccharide AP1-1 was obtained from PE by macroporous adsorption resin chromatography, DEAE cellulose chromatography, and Sephadex gel chromatography; the homogeneity and the molecular weight of AP1-1 were determined by gel filtration; and the acid hydrolysis, periodate oxidation, Smith degradation, and NMR analysis were used to analyze the chemical structure of AP1-1.	Polysaccharides	13-27	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	211-216
24654772-3	2014	The result showed that AP1-1 was a homogeneous polysaccharide, whose relative molecular weight was 9.97 x 10(4).	Polysaccharides	47-61	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	23-28
24286246-3	2014	Heparanase is the sole mammalian enzyme (endo-beta-d-glucuronidase) degrading heparan sulphate glycosaminoglycan, key polysaccharide of the extracellular matrix.	Polysaccharides	118-132	glucuronidase beta	Homo sapiens	46-66
25152896-4	2014	Gd-IgA1 is recognized as an autoantigen in susceptible individuals by anti-glycan autoantibodies, resulting in immune complexes that may ultimately deposit in the kidney and induce glomerular injury.	Polysaccharides	75-81	immunoglobulin heavy constant alpha 1	Homo sapiens	3-7
24723960-1	2014	Recently studies performed on mushroom isolated polysaccharides demonstrated that beta -(1,3)-glucan may affect the balance of Th1/Th2 cell response.	Polysaccharides	48-63	negative elongation factor complex member C/D, Th1l	Mus musculus	127-130
24642659-1	2014	BACKGROUND: Fever, leukocytosis, and large local reactions following the pneumococcal polysaccharide vaccine (PS23) have been described only in isolated case reports in the adult literature.	Polysaccharides	86-100	protein S	Homo sapiens	110-114
24218480-3	2014	Using a synthetic polysaccharide antigen, it has previously been shown that TACI is critical for T cell-independent antibody responses.	Polysaccharides	18-32	tumor necrosis factor receptor superfamily, member 13b	Mus musculus	76-80
24218480-8	2014	In contrast, TACI-deficient mice immunized with heat-killed type 3 serotype pneumococcus cells are impaired in generating pneumococcal polysaccharide-specific responses and succumb to challenge with live type 3 serotype pneumococcus, indicating that TACI is required for T cell-independent antibody responses to bacterial-associated polysaccharides.	Polysaccharides	135-149	tumor necrosis factor receptor superfamily, member 13b	Mus musculus	13-17
24218480-8	2014	In contrast, TACI-deficient mice immunized with heat-killed type 3 serotype pneumococcus cells are impaired in generating pneumococcal polysaccharide-specific responses and succumb to challenge with live type 3 serotype pneumococcus, indicating that TACI is required for T cell-independent antibody responses to bacterial-associated polysaccharides.	Polysaccharides	333-348	tumor necrosis factor receptor superfamily, member 13b	Mus musculus	13-17
24335201-3	2014	CFH, in conjunction with other factors, regulates complement activation in host tissues, and the Y402H polymorphism has been found to alter the protein"s specificity for heparan sulphate (HS) - a complex polysaccharide found ubiquitously in mammals.	Polysaccharides	204-218	complement factor H	Homo sapiens	0-3
24336744-1	2014	An acidic polysaccharide (SGP-2), with a molecular weight of 1880 kDa, was purified from the defatted whole-plant of Sarcandra glabra (Thunb.)	Polysaccharides	10-24	clusterin	Homo sapiens	26-31
25188662-5	2014	Notably, Gal1 adheres selectively to the NRP-1/PlexinA4 receptor complex in injured neurons through glycan-dependent mechanisms, interrupts the Sema3A pathway and contributes to axonal regeneration and locomotor recovery after SCI.	Polysaccharides	100-106	galectin 1	Homo sapiens	9-13
25048016-0	2014	Anti-tumor effect of polysaccharides from Scutellaria barbata D. Don on the 95-D xenograft model via inhibition of the C-met pathway.	Polysaccharides	21-36	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	119-124
24173215-2	2014	Glycan microarray analysis reveals that both viruses exhibit a strong shift toward binding to "human-type" alpha2-6 sialosides but with notable differences in fine specificity.	Polysaccharides	0-6	immunoglobulin binding protein 1	Homo sapiens	107-115
25188662-5	2014	Notably, Gal1 adheres selectively to the NRP-1/PlexinA4 receptor complex in injured neurons through glycan-dependent mechanisms, interrupts the Sema3A pathway and contributes to axonal regeneration and locomotor recovery after SCI.	Polysaccharides	100-106	neuropilin 1	Homo sapiens	41-46
25188662-5	2014	Notably, Gal1 adheres selectively to the NRP-1/PlexinA4 receptor complex in injured neurons through glycan-dependent mechanisms, interrupts the Sema3A pathway and contributes to axonal regeneration and locomotor recovery after SCI.	Polysaccharides	100-106	plexin A4	Homo sapiens	47-55
25117229-2	2014	Here, we describe the use of the virus itself as a specific antibody coupled to enzymes (virus with neuraminidase spikes) for determining its binding specificity to glycans, a strategy that reduces not only the cost but also the tedious steps of adding primary and secondary antibodies and washing between each step.	Polysaccharides	165-172	neuraminidase 1	Homo sapiens	100-113
24085812-12	2014	The glycan structural analysis of PON1 by MS/MS identified a biantennary fucosylated glycan modification consisting of a core + 2HexNAc + 1Fuc at increased levels in the sera of patients with SCLC.	Polysaccharides	4-10	paraoxonase 1	Homo sapiens	34-38
24947385-3	2014	Using a fluorescence resonance energy transfer technique, we investigated the role of glycan structure on the internalization of insulin-responsive glucose transporter GLUT4.	Polysaccharides	86-92	solute carrier family 2 member 4	Homo sapiens	168-173
24085812-12	2014	The glycan structural analysis of PON1 by MS/MS identified a biantennary fucosylated glycan modification consisting of a core + 2HexNAc + 1Fuc at increased levels in the sera of patients with SCLC.	Polysaccharides	85-91	paraoxonase 1	Homo sapiens	34-38
24292068-3	2014	Here, we show that increasing sialylated glycans on cancer cells inhibits human natural killer (NK) cell activation through the recruitment of sialic acid-binding immunoglobulin-like lectin 7 (Siglec-7).	Polysaccharides	41-48	sialic acid binding Ig like lectin 7	Homo sapiens	143-191
24292068-3	2014	Here, we show that increasing sialylated glycans on cancer cells inhibits human natural killer (NK) cell activation through the recruitment of sialic acid-binding immunoglobulin-like lectin 7 (Siglec-7).	Polysaccharides	41-48	sialic acid binding Ig like lectin 7	Homo sapiens	193-201
24217250-0	2013	Common polymorphisms in human langerin change specificity for glycan ligands.	Polysaccharides	62-68	CD207 molecule	Homo sapiens	30-38
23922174-0	2014	Antitumor activity of a polysaccharide fraction from Laminaria japonica on U14 cervical carcinoma-bearing mice.	Polysaccharides	24-38	small nucleolar RNA, C/D box 14C	Mus musculus	75-78
24076340-0	2013	Co-delivery of viral proteins and a TLR7 agonist from polysaccharide nanocapsules: a needle-free vaccination strategy.	Polysaccharides	54-68	toll-like receptor 7	Mus musculus	36-40
24717697-8	2014	Whole and whole lactose-free milk produced lower biomass and less insoluble polysaccharides than the other treatments in enamel and dentin (P&lt;.05).	Polysaccharides	76-91	Weaning weight-maternal milk	Bos taurus	29-33
24217250-2	2013	Langerin binds a diverse range of carbohydrates including high mannose structures, fucosylated blood group antigens, and glycans with terminal 6-sulfated galactose.	Polysaccharides	121-128	CD207 molecule	Homo sapiens	0-8
24217250-8	2013	Langerin with Asp-288 and Ile-313 shows no binding to 6SO4-Gal-terminated glycans and increased binding to GlcNAc-terminated structures, but overall decreased binding to glycans.	Polysaccharides	170-177	CD207 molecule	Homo sapiens	0-8
24367694-4	2013	We found that PLMs activate caspase-1 in murine macrophage cell line J774 independent of the glycan chain length although IL-1beta secretion is more intense with long glycan chain.	Polysaccharides	167-173	interleukin 1 beta	Mus musculus	122-130
24379273-10	2013	The receptor site for the EBA-140 ligand was suggested to be a cluster of N-and O-linked sialylated glycans on the GPC molecule, whose conformation is dependent on the polypeptide chain region composed of amino acid residues 36-63.	Polysaccharides	100-107	glycophorin C (Gerbich blood group)	Homo sapiens	115-118
24161263-0	2013	Glycan structure determinants for cation-independent mannose 6-phosphate receptor binding and cellular uptake of a recombinant protein.	Polysaccharides	0-6	insulin like growth factor 2 receptor	Homo sapiens	34-81
24161263-7	2013	These results demonstrate that the phosphorylated dimannose moiety appears to be the minimal structure determinant for enhanced CI-MPR binding and that the orientation of the glycan is critical for maximum receptor interaction.	Polysaccharides	175-181	insulin like growth factor 2 receptor	Homo sapiens	128-134
24344650-1	2013	BACKGROUND: The differentiation resp. death of human monocytic THP-1 cells induced by polysaccharide extracts of the medicinal mushrooms Phellinus linteus, Agaricus bisporus and Agaricus brasiliensis have been studied.	Polysaccharides	86-100	GLI family zinc finger 2	Homo sapiens	63-68
24344650-3	2013	METHODS: THP-1 cells were treated with different polysaccharide extracts of mushrooms and controls.	Polysaccharides	49-63	GLI family zinc finger 2	Homo sapiens	9-14
24344650-7	2013	RESULTS: P. linteus polysaccharide extracts induced dose-dependent apoptosis of THP-1 cells within 24 h, while A. bisporus and A. brasiliensis polysaccharide extracts caused differentiation into macrophages.	Polysaccharides	20-34	GLI family zinc finger 2	Homo sapiens	80-85
24344650-13	2013	CONCLUSIONS: P. linteus polysaccharide extracts caused apoptosis of THP-1 monocytes while A. bisporus and A. brasiliensis polysaccharide extracts caused these cells to differentiate into macrophages.	Polysaccharides	24-38	GLI family zinc finger 2	Homo sapiens	68-73
24329421-7	2013	Biochemical (LPO, SOD and CAT) and histological evaluation (p &lt; 0.01) confirmed the anti-hepatotoxic and antioxidant property of crude polysaccharide against d-Gal-induced elevation of LPO and infiltration of inflammatory cells into liver tissue.	Polysaccharides	138-152	catalase	Rattus norvegicus	26-29
23993501-1	2013	This study was to examine the hepatoprotective effects of polysaccharides from green tea of Huangshan Maofeng (HMTP) against CCl4-induced oxidative damage in mice.	Polysaccharides	58-73	chemokine (C-C motif) ligand 4	Mus musculus	125-129
24227777-0	2013	Polysaccharide-specific memory B cells generated by conjugate vaccines in humans conform to the CD27+IgG+ isotype-switched memory B Cell phenotype and require contact-dependent signals from bystander T cells activated by bacterial proteins to differentiate into plasma cells.	Polysaccharides	0-14	CD27 molecule	Homo sapiens	96-100
24307362-3	2013	To enable future binding studies of mucin glycan and glycopeptide probes, a method that gives flexible and efficient access to all common mucin core-glycosylated amino acids was developed.	Polysaccharides	42-48	LOC100508689	Homo sapiens	36-41
24106205-4	2013	We have characterized terminal glycan expression on platelet-VWF.	Polysaccharides	31-37	von Willebrand factor	Homo sapiens	61-64
24335029-1	2013	In this issue of Blood, McGrath et al show that the terminal glycan structures of platelet von Willebrand factor (VWF) are markedly different compared with such structures present on plasma VWF.1 Unexpectedly, these differences endow platelet VWF with a specific resistance against proteolysis by the VWF-cleaving protease ADAMTS13, thereby potentially increasing the hemostatic potential of platelet VWF during the formation of platelet-rich thrombi.	Polysaccharides	61-67	von Willebrand factor	Homo sapiens	91-112
24335029-1	2013	In this issue of Blood, McGrath et al show that the terminal glycan structures of platelet von Willebrand factor (VWF) are markedly different compared with such structures present on plasma VWF.1 Unexpectedly, these differences endow platelet VWF with a specific resistance against proteolysis by the VWF-cleaving protease ADAMTS13, thereby potentially increasing the hemostatic potential of platelet VWF during the formation of platelet-rich thrombi.	Polysaccharides	61-67	von Willebrand factor	Homo sapiens	114-117
24340011-12	2013	Finally, we demonstrated that endocan could stimulate the migration and invasion ability of endothelial cells and this activity of endocan was dependent on the glycan moiety and the phenylalanine-rich region of endocan.	Polysaccharides	160-166	endothelial cell specific molecule 1	Homo sapiens	30-37
24100026-0	2013	Glycan-dependent and -independent interactions contribute to cellular substrate recruitment by calreticulin.	Polysaccharides	0-6	calreticulin	Homo sapiens	95-107
24100026-4	2013	Although both interactions involve the glycan-binding site or its vicinity, the arm-like proline-rich (P-) domain of calreticulin contributes to binding non/deglycosylated proteins.	Polysaccharides	39-45	calreticulin	Homo sapiens	117-129
24100026-8	2013	Substrate sequestration in the cleft between the glycan-binding site and P-domain is a likely mechanism for calreticulin-assisted protein folding.	Polysaccharides	49-55	calreticulin	Homo sapiens	108-120
24324808-8	2013	Among glycan traits with low heritability probe cg08392591 maps to a CpG island 5" from the ANKRD11 gene, a p53 activator on chromosome 16.	Polysaccharides	6-12	ankyrin repeat domain containing 11	Homo sapiens	92-99
24324808-8	2013	Among glycan traits with low heritability probe cg08392591 maps to a CpG island 5" from the ANKRD11 gene, a p53 activator on chromosome 16.	Polysaccharides	6-12	tumor protein p53	Homo sapiens	108-111
24340011-12	2013	Finally, we demonstrated that endocan could stimulate the migration and invasion ability of endothelial cells and this activity of endocan was dependent on the glycan moiety and the phenylalanine-rich region of endocan.	Polysaccharides	160-166	endothelial cell specific molecule 1	Homo sapiens	131-138
24340011-12	2013	Finally, we demonstrated that endocan could stimulate the migration and invasion ability of endothelial cells and this activity of endocan was dependent on the glycan moiety and the phenylalanine-rich region of endocan.	Polysaccharides	160-166	endothelial cell specific molecule 1	Homo sapiens	131-138
23708323-1	2013	INTRODUCTION: Endothelial-cell-specific molecule-1 or endocan is a proteoglycan with tumorigenic activity through both its glycan and protein cores.	Polysaccharides	73-79	endothelial cell specific molecule 1	Homo sapiens	14-50
24142515-9	2013	Diminished steady-state levels of glycan-deficient ABCA3 isoforms were rescued by treatment with the proteasome inhibitor MG132.	Polysaccharides	34-40	ATP binding cassette subfamily A member 3	Homo sapiens	51-56
23708323-1	2013	INTRODUCTION: Endothelial-cell-specific molecule-1 or endocan is a proteoglycan with tumorigenic activity through both its glycan and protein cores.	Polysaccharides	73-79	endothelial cell specific molecule 1	Homo sapiens	54-61
23979800-4	2013	Some of the recombinant mannosidases were demonstrably active towards oligomannosidic glycans, specifically, the Co(II)-requiring ManIIb, two "acidic" mannosidases and the class I mas-1 mannosidase.	Polysaccharides	86-93	alpha-Mannosidase class II b	Drosophila melanogaster	130-136
23850176-7	2013	Their Vmax values were markedly higher in the river water than in the seawater and their ratio suggested that most of the DOM used by microbes in the Arno River was polysaccharide-like, while in the seawater it was mainly protein-like.	Polysaccharides	165-179	cytohesin 2	Homo sapiens	150-154
24290991-0	2013	Expression of integrins alpha3beta1 and alpha5beta1 and GlcNAc beta1,6 glycan branching influences metastatic melanoma cell migration on fibronectin.	Polysaccharides	71-77	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	63-70
24290991-0	2013	Expression of integrins alpha3beta1 and alpha5beta1 and GlcNAc beta1,6 glycan branching influences metastatic melanoma cell migration on fibronectin.	Polysaccharides	71-77	fibronectin 1	Homo sapiens	137-148
24129747-2	2013	polysaccharides upregulate Wnt/beta-catenin signaling in chondrocytes.	Polysaccharides	0-15	Wnt family member 2	Rattus norvegicus	27-30
24126111-8	2013	In conclusion, we have established a useful model for the study of intestinal damage and recovery using human colon epithelial cells and our data suggest that damage to human colon epithelial cells can, at least in part, be recovered by the autonomous production of IL-22 in response to Spirulina complex polysaccharides.	Polysaccharides	305-320	interleukin 22	Homo sapiens	266-271
24129747-2	2013	polysaccharides upregulate Wnt/beta-catenin signaling in chondrocytes.	Polysaccharides	0-15	catenin beta 1	Rattus norvegicus	31-43
23639628-11	2013	High levels of anti-GP2 correlated with more frequent bowel movements per day and with the presence of at least one anti-glycan antibody (p&lt;=0.05).	Polysaccharides	121-127	glycoprotein 2	Homo sapiens	20-23
23898885-0	2013	Characterization and downstream mannose phosphorylation of human recombinant alpha-L-iduronidase produced in Arabidopsis complex glycan-deficient (cgl) seeds.	Polysaccharides	129-135	alpha-L-iduronidase	Homo sapiens	77-96
23911414-1	2013	Among the non-carbohydrate components of glycans, the addition of phosphocholine (ChoP) to the glycans of pathogens occurs more rarely than acetylation or methylation, but it has far more potent biological consequences.	Polysaccharides	41-48	DNA damage inducible transcript 3	Homo sapiens	82-86
23911414-1	2013	Among the non-carbohydrate components of glycans, the addition of phosphocholine (ChoP) to the glycans of pathogens occurs more rarely than acetylation or methylation, but it has far more potent biological consequences.	Polysaccharides	95-102	DNA damage inducible transcript 3	Homo sapiens	82-86
23911414-6	2013	We describe the biosynthesis of the ChoP modification, the structures of the pathogen glycans known to carry ChoP groups and the host proteins that recognize ChoP.	Polysaccharides	86-93	DNA damage inducible transcript 3	Homo sapiens	36-40
23911414-6	2013	We describe the biosynthesis of the ChoP modification, the structures of the pathogen glycans known to carry ChoP groups and the host proteins that recognize ChoP.	Polysaccharides	86-93	DNA damage inducible transcript 3	Homo sapiens	109-113
23911414-6	2013	We describe the biosynthesis of the ChoP modification, the structures of the pathogen glycans known to carry ChoP groups and the host proteins that recognize ChoP.	Polysaccharides	86-93	DNA damage inducible transcript 3	Homo sapiens	109-113
24115046-5	2013	The predominant LCAT N-linked glycoforms are biantennary glycans, followed by triantennary sugars, whereas the level of tetraantennary glycans is much lower.	Polysaccharides	57-64	lecithin-cholesterol acyltransferase	Homo sapiens	16-20
24115046-5	2013	The predominant LCAT N-linked glycoforms are biantennary glycans, followed by triantennary sugars, whereas the level of tetraantennary glycans is much lower.	Polysaccharides	135-142	lecithin-cholesterol acyltransferase	Homo sapiens	16-20
24155237-0	2013	Enzymatic basis for N-glycan sialylation: structure of rat alpha2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation.	Polysaccharides	22-28	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Rattus norvegicus	87-94
24102742-5	2013	Rny1p transport to the Golgi results in the further attachment of high-glycans.	Polysaccharides	71-78	ribonuclease T2	Saccharomyces cerevisiae S288C	0-5
24155237-4	2013	We examined the enzymatic basis for glycan sialylation in animal systems by determining the crystal structures of rat ST6GAL1, an enzyme that creates terminal alpha2,6-sialic acid linkages on complex-type N-glycans, at 2.4 A resolution.	Polysaccharides	36-42	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Rattus norvegicus	118-125
24229406-0	2013	Inducement of cytokine release by GFPBW2, a novel polysaccharide from fruit bodies of Grifola frondosa , through dectin-1 in macrophages.	Polysaccharides	50-64	C-type lectin domain family 7, member a	Mus musculus	113-121
24060681-0	2013	Activation of P27kip1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells.	Polysaccharides	50-64	cyclin dependent kinase inhibitor 1B	Homo sapiens	14-21
24060681-0	2013	Activation of P27kip1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells.	Polysaccharides	50-64	cyclin D1	Homo sapiens	22-31
24060681-0	2013	Activation of P27kip1-cyclin D1/E-CDK2 pathway by polysaccharide from Phellinus linteus leads to S-phase arrest in HT-29 cells.	Polysaccharides	50-64	cyclin dependent kinase 2	Homo sapiens	34-38
24200110-2	2013	The present study investigates the inhibitory effect of a bioprocessed polysaccharide (BPP) isolated from the edible Lentinus edodes liquid mycelial mushroom culture supplemented with black rice bran against murine endotoxemia induced by the Salmonella lipopolysaccharide and d-galactosamine (LPS/GalN).	Polysaccharides	71-85	galanin and GMAP prepropeptide	Mus musculus	297-301
23994444-11	2013	As an example, the identified membrane protein SKU5 (AT4G12420) showed differential glycopeptide intensity ratios between WT and cgl indicating heterogeneous glycan modification on single protein.	Polysaccharides	158-164	Cupredoxin superfamily protein	Arabidopsis thaliana	47-51
24108122-2	2013	We recently identified the unique ligand specificity of mouse DCIR2 (mDCIR2) toward biantennary complex-type glycans containing bisecting N-acetylglucosamine (GlcNAc).	Polysaccharides	109-116	C-type lectin domain family 4, member a4	Mus musculus	62-67
24108122-2	2013	We recently identified the unique ligand specificity of mouse DCIR2 (mDCIR2) toward biantennary complex-type glycans containing bisecting N-acetylglucosamine (GlcNAc).	Polysaccharides	109-116	C-type lectin domain family 4, member a4	Mus musculus	69-75
24108122-6	2013	Our structural and biochemical data elucidate for the first time the unique binding mode of mDCIR2 for bisecting GlcNAc-containing glycans, a mode that contrasts sharply with that of other immune C-type lectin receptors such as DC-SIGN.	Polysaccharides	131-138	C-type lectin domain family 4, member a4	Mus musculus	92-98
24261589-1	2013	BACKGROUND: Influenza A virus (IAV) neuraminidase (NA) cleaves sialic acids (Sias) from glycans.	Polysaccharides	88-95	neuraminidase 1	Homo sapiens	36-49
24256719-0	2013	AGO61-dependent GlcNAc modification primes the formation of functional glycans on alpha-dystroglycan.	Polysaccharides	71-78	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	0-5
24051158-10	2013	These results demonstrate that the gp120/654 complex is a potent immunogen for eliciting cross-reactive functional NAbs against V3 epitopes, of which exposure is determined by the specific compositions of glycans shrouding the HIV-1 envelope glycoproteins.	Polysaccharides	205-212	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	35-44
24256719-3	2013	Here we show the phenotypes of AGO61-knockout mice and demonstrate that AGO61 is indispensable for the formation of laminin-binding glycans of alpha-DG.	Polysaccharides	132-139	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	72-77
24256719-4	2013	AGO61-knockout mouse brain exhibited abnormal basal lamina formation and a neuronal migration defect due to a lack of laminin-binding glycans.	Polysaccharides	134-141	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	0-5
24000773-2	2013	The development and manufacture of a liquid glycoconjugate vaccine against MenA are hampered by the poor hydrolytic stability of its capsular polysaccharide (CPS), consisting of (1 6)-linked 2-acetamido-2-deoxy-alpha-d-mannopyranosyl phosphate repeating units.	Polysaccharides	142-156	ENAH actin regulator	Mus musculus	75-79
24000773-5	2013	After immunization in mice, only the conjugated trimer was able to induce specific anti-MenA polysaccharide IgG antibodies with in vitro bactericidal activity, although to a lesser extent than pentadecamer and hexamer oligomers obtained from mild acid hydrolysis of the native polysaccharide conjugated to the same protein carrier.	Polysaccharides	93-107	ENAH actin regulator	Mus musculus	88-92
24062310-7	2013	Furthermore, we present evidence that the purified OST complex can generate fOSs by hydrolyzing dolichol-linked oligosaccharide, the glycan donor substrate for N-glycosylation.	Polysaccharides	133-139	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	51-54
24079703-7	2013	Six polysaccharides isolated from S. horneri were found to efficiently interfere with the HVEM-gD interaction.	Polysaccharides	4-19	TNF receptor superfamily member 14	Homo sapiens	90-94
23986319-17	2013	vaccination aided by a TLR4 agonist results in robust immune responses to both the carrier protein and bacterial polysaccharide components of the Hibv.	Polysaccharides	113-127	toll-like receptor 4	Mus musculus	23-27
23767872-2	2013	One of these potential vulnerabilities includes the dense cluster of carbohydrates surrounding HIV-1"s envelope glycoproteins gp120 and gp41, typically referred to as the "glycan shield."	Polysaccharides	172-178	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	126-131
24222121-1	2013	BACKGROUND/AIM: A protein-bound polysaccharide, polysaccharide K (PSK), is a non-specific immunological agent used in the treatment of colon cancer, however few studies have investigated the genetic changes in cancer cells treated with PSK.	Polysaccharides	32-46	TAO kinase 2	Homo sapiens	66-69
24222121-1	2013	BACKGROUND/AIM: A protein-bound polysaccharide, polysaccharide K (PSK), is a non-specific immunological agent used in the treatment of colon cancer, however few studies have investigated the genetic changes in cancer cells treated with PSK.	Polysaccharides	32-46	TAO kinase 2	Homo sapiens	236-239
23380706-2	2013	These events include structural remodeling of both the lipid and glycan moieties of GPI, recruitment of GPI-APs into ER exit sites, association with the cargo receptor, p24 protein complex, and packaging into COPII coated transport vesicles.	Polysaccharides	65-71	glucose-6-phosphate isomerase	Homo sapiens	84-87
24036269-2	2013	However, factor IX (FIX) variants with additional N-linked glycans ("HG" variants) that were expressed in HKB11 cells showed increased clearance in rat in vivo pharmacokinetic studies relative to FIX variants with no additional glycans.	Polysaccharides	59-66	coagulation factor IX	Homo sapiens	9-18
24051301-11	2013	The observed alterations in GP2, GP4 and GP6 may be related to altered glycosylation and remodelling of the glycan branches of the IgG molecule.	Polysaccharides	108-114	glycoprotein 2	Homo sapiens	28-31
24051301-11	2013	The observed alterations in GP2, GP4 and GP6 may be related to altered glycosylation and remodelling of the glycan branches of the IgG molecule.	Polysaccharides	108-114	CD36 molecule	Homo sapiens	33-36
24051301-11	2013	The observed alterations in GP2, GP4 and GP6 may be related to altered glycosylation and remodelling of the glycan branches of the IgG molecule.	Polysaccharides	108-114	glycoprotein VI platelet	Homo sapiens	41-44
24956826-1	2013	OBJECTIVE: To study the effects of polysaccharides from Bletillae Rhizoma (RBP) on the protection in rats during deep second-degree burn wound healing.	Polysaccharides	35-50	retinol binding protein 4	Rattus norvegicus	75-78
24361107-7	2013	Out of several synthetic glycans representing Echinococcus LL structures, the KCR bound strongly in particular to those ending in Galalpha1-4Galbeta1-3 or Galalpha1-4Galbeta1-4GlcNAc, both characteristic LL carbohydrate motifs.	Polysaccharides	25-32	C-type lectin domain family 4, member f	Mus musculus	78-81
24097413-3	2013	Previous structural analysis suggests that this glycan fills a void between the gp120 V5 loop and the ibalizumab light chain, perhaps causing steric hindrance that disrupts viral entry.	Polysaccharides	48-54	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	80-85
23879746-1	2013	A protein-bound polysaccharide fraction (JBP-1) was obtained from the fruiting bodies of Cantharellus cibarius.	Polysaccharides	16-30	protein arginine N-methyltransferase 5	Mus musculus	41-46
23959967-4	2013	Indeed, NoVs use glycans of the ABH and Lewis histo-blood group antigen family (HBGAs) as attachment factors.	Polysaccharides	17-24	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	32-35
24074568-3	2013	Sequence analysis of gp120 showed that most had deletions of 1 to 5 mannose-rich glycans.	Polysaccharides	81-88	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	21-26
24074599-1	2013	Human influenza viruses predominantly bind alpha2,6 linked sialic acid (SA) while avian viruses bind alpha2,3 SA-containing complex glycans.	Polysaccharides	132-139	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	101-109
24072822-4	2013	Glycans associated with MUC2 imprinted DCs with anti-inflammatory properties by assembling a galectin-3-Dectin-1-FcgammaRIIB receptor complex that activated beta-catenin.	Polysaccharides	0-7	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	24-28
24001891-0	2013	Polysaccharide from Phellinus linteus induces S-phase arrest in HepG2 cells by decreasing calreticulin expression and activating the P27kip1-cyclin A/D1/E-CDK2 pathway.	Polysaccharides	0-14	calreticulin	Homo sapiens	90-102
24001891-0	2013	Polysaccharide from Phellinus linteus induces S-phase arrest in HepG2 cells by decreasing calreticulin expression and activating the P27kip1-cyclin A/D1/E-CDK2 pathway.	Polysaccharides	0-14	cyclin dependent kinase inhibitor 1B	Homo sapiens	133-140
24001891-0	2013	Polysaccharide from Phellinus linteus induces S-phase arrest in HepG2 cells by decreasing calreticulin expression and activating the P27kip1-cyclin A/D1/E-CDK2 pathway.	Polysaccharides	0-14	cyclin A2	Homo sapiens	141-149
24001891-0	2013	Polysaccharide from Phellinus linteus induces S-phase arrest in HepG2 cells by decreasing calreticulin expression and activating the P27kip1-cyclin A/D1/E-CDK2 pathway.	Polysaccharides	0-14	cyclin dependent kinase 2	Homo sapiens	155-159
24072822-4	2013	Glycans associated with MUC2 imprinted DCs with anti-inflammatory properties by assembling a galectin-3-Dectin-1-FcgammaRIIB receptor complex that activated beta-catenin.	Polysaccharides	0-7	catenin beta 1	Homo sapiens	157-169
24205278-0	2013	Dectin-2-dependent NKT cell activation and serotype-specific antibody production in mice immunized with pneumococcal polysaccharide vaccine.	Polysaccharides	117-131	C-type lectin domain family 4, member n	Mus musculus	0-8
24204617-0	2013	Utilisation of mucin glycans by the human gut symbiont Ruminococcus gnavus is strain-dependent.	Polysaccharides	21-28	LOC100508689	Homo sapiens	15-20
24204617-5	2013	Comparative genomic analysis of the two R. gnavus strains highlighted potential clusters and glycoside hydrolases (GHs) responsible for the breakdown and utilization of mucin-derived glycans.	Polysaccharides	183-190	LOC100508689	Homo sapiens	169-174
24062455-3	2013	The fecal microbiota of Fut2(-) mice that lack fucosylated host glycans show decreased alpha diversity relative to Fut2(+) mice and exhibit significant differences in community composition.	Polysaccharides	64-71	fucosyltransferase 2	Mus musculus	24-28
23987429-1	2013	The extracellular polysaccharide (LEP) produced by Lachnum YM281 was obtained from the fermentation broth, and LEP-1b with molecular weight of 4.02x10(4) Da was separated and sequentially purified through DEAE-cellulose 52 column chromatography and Sepharose CL-6B column chromatography.	Polysaccharides	18-32	leptin	Mus musculus	34-37
23987429-1	2013	The extracellular polysaccharide (LEP) produced by Lachnum YM281 was obtained from the fermentation broth, and LEP-1b with molecular weight of 4.02x10(4) Da was separated and sequentially purified through DEAE-cellulose 52 column chromatography and Sepharose CL-6B column chromatography.	Polysaccharides	18-32	leptin	Mus musculus	111-114
23987469-1	2013	A water-soluble polysaccharide (FAAP-02), composed of N-acetyl-D-glucosamine, glucose, mannose, galactose, rhamnose, arabinose, xylose and ribose, with an average molecular weight of 5169 Da, was isolated from Artemisia argyi.	Polysaccharides	16-30	RNA 2',3'-cyclic phosphate and 5'-OH ligase	Mus musculus	32-36
24176078-5	2013	We found that a proportion of Rev 1 R mutants result from genome rearrangements affecting the wbo O-polysaccharide loci of genomic island GI-2 and the wbkA O-polysaccharide glycosyltransferase gene of the wbk region.	Polysaccharides	100-114	REV1, DNA directed polymerase	Mus musculus	30-35
23987321-0	2013	Preparation of carboxylic acid-bearing polysaccharide nanofiber made from euglenoid beta-1,3-glucans.	Polysaccharides	39-53	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	84-92
23987364-0	2013	Chemical modification, antioxidant and alpha-amylase inhibitory activities of corn silk polysaccharides.	Polysaccharides	88-103	alpha-amylase	Zea mays	39-52
23987364-3	2013	Among the three derivatives, carboxylmethylated polysaccharide (C-CSPS) demonstrated higher solubility, narrower molecular weight distribution, lower intrinsic viscosity, a hyperbranched conformation, significantly higher antioxidant and alpha-amylase inhibitory abilities compared with the native polysaccharide and other derivatives.	Polysaccharides	48-62	alpha-amylase	Zea mays	238-251
24062455-4	2013	A glucose-rich plant polysaccharide-deficient (PD) diet exerted a strong effect on the microbiota membership but eliminated the effect of Fut2 genotype.	Polysaccharides	21-35	fucosyltransferase 2	Mus musculus	138-142
24311874-1	2013	The objective of this paper was to extract and purify lily polysaccharide and to study its anti-H22 hepatoma effect in mice.	Polysaccharides	59-73	histocompatibility 22	Mus musculus	96-99
24035193-5	2013	GMPPB catalyzes the formation of GDP-mannose, which is an essential precursor of glycan moieties of glycoproteins and glycolipids and is associated with congenital and limb-girdle muscular dystrophies with hypoglycosylation of alpha-dystroglycan.	Polysaccharides	81-87	GDP-mannose pyrophosphorylase B	Homo sapiens	0-5
24107297-4	2013	Two Tfp subunits, PilE and PilQ, are identified as the ligands for TNF-alpha and IL-8 in a glycan-dependent manner, and their deletion results in decreased virulence and increased survival in a mouse model.	Polysaccharides	91-97	tripartite motif-containing 39	Mus musculus	4-7
24107297-4	2013	Two Tfp subunits, PilE and PilQ, are identified as the ligands for TNF-alpha and IL-8 in a glycan-dependent manner, and their deletion results in decreased virulence and increased survival in a mouse model.	Polysaccharides	91-97	tumor necrosis factor	Mus musculus	67-76
24107297-4	2013	Two Tfp subunits, PilE and PilQ, are identified as the ligands for TNF-alpha and IL-8 in a glycan-dependent manner, and their deletion results in decreased virulence and increased survival in a mouse model.	Polysaccharides	91-97	chemokine (C-X-C motif) ligand 15	Mus musculus	81-85
24311874-2	2013	Orthogonal experimental method was used to analyze the factors influencing the extraction and purification of lily polysaccharide, and the anti-tumor effect of lily polysaccharide was studied by acting it on H22-bearing mice.	Polysaccharides	165-179	histocompatibility 22	Mus musculus	208-211
24311874-4	2013	Lily polysaccharide can enhance the immune function of H22 tumor-bearing mice, and inhibit the growth of H22 tumor.	Polysaccharides	5-19	histocompatibility 22	Mus musculus	55-58
23920220-10	2013	Oat3 also plays a role in bioenergetic pathways (e.g., the tricarboxylic acid cycle), as well as those involving vitamins (e.g., folate), steroids, prostaglandins, gut microbiome products, uremic toxins, cyclic nucleotides, amino acids, glycans, and possibly hyaluronic acid.	Polysaccharides	237-244	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	0-4
23836288-6	2013	Analyses of N-glycosylation in agl-1(RNAi) animals by western blotting and mass spectrometry showed reduction of paucimannose and complex-type glycans and dramatic increase of glucosylated oligomannose glycans.	Polysaccharides	143-150	4-alpha-glucanotransferase	Caenorhabditis elegans	31-36
23968720-2	2013	While analyzing human sperm motility, we found that sperm treated with endo-beta-galactosidase (EBG), which specifically hydrolyzes poly-N-acetyllactosamine type glycans (polyLacs), enhanced motility.	Polysaccharides	162-169	galactosidase beta 1	Homo sapiens	76-94
23973497-2	2013	After denaturation in dilute NaOH solution (0.3 M) and renaturation by sequential dialysis, regenerated polysaccharide (RPD3) was obtained.	Polysaccharides	104-118	histone deacetylase 1, pseudogene	Mus musculus	120-124
23876803-5	2013	Mice lacking these glycans still produce Muc2 but display a thinner intestinal mucus barrier.	Polysaccharides	19-26	mucin 2	Mus musculus	41-45
23973497-7	2013	Meanwhile, RPD3 in high-dose group showed much higher anti-tumor activity than that of PD3, suggesting that the denaturation-renaturation treatment improved the bioactivity of the polysaccharide from D. indusiata.	Polysaccharides	180-194	histone deacetylase 1, pseudogene	Mus musculus	11-15
24273483-1	2013	Human erythropoietin (Epo) is a 30.4 kDa glycoprotein hormone composed of a single 165 amino acid residues chain to which four glycans are attached.	Polysaccharides	127-134	erythropoietin	Homo sapiens	6-20
23808939-9	2013	One broadly neutralizing serum (Serum 45) was identified to contain antibodies with unknown epitope specificities that were sensitive to terminal glycan modifications on virus Env and insensitive to N160K mutagenesis, and correlated with the cross-clade neutralization activity of Serum 45.	Polysaccharides	146-152	endogenous retrovirus group K member 20	Homo sapiens	176-179
23764502-8	2013	The glycans on PSA are believed to be biantennary N-linked, and it has been observed that prostate cancer tissues and cell lines contain more antennae than their benign counterparts.	Polysaccharides	4-11	kallikrein related peptidase 3	Homo sapiens	15-18
24065532-6	2013	In contrast, mRNA expression of tissue inhibitor of matrix metalloproteinase (TIMP)-1, a MMP inhibitor, was increased by 10-120 mug/ml of PS but not that of TIMP-2.	Polysaccharides	138-140	TIMP metallopeptidase inhibitor 1	Homo sapiens	32-85
24065532-6	2013	In contrast, mRNA expression of tissue inhibitor of matrix metalloproteinase (TIMP)-1, a MMP inhibitor, was increased by 10-120 mug/ml of PS but not that of TIMP-2.	Polysaccharides	138-140	matrix metallopeptidase 9	Homo sapiens	89-92
24065532-7	2013	We also found that PS reversed the phosphorylations of p38, ERK and JNK but not IkappaBalpha and NF-kappaB.	Polysaccharides	19-21	mitogen-activated protein kinase 14	Homo sapiens	55-58
24065532-7	2013	We also found that PS reversed the phosphorylations of p38, ERK and JNK but not IkappaBalpha and NF-kappaB.	Polysaccharides	19-21	mitogen-activated protein kinase 1	Homo sapiens	60-63
24065532-7	2013	We also found that PS reversed the phosphorylations of p38, ERK and JNK but not IkappaBalpha and NF-kappaB.	Polysaccharides	19-21	mitogen-activated protein kinase 8	Homo sapiens	68-71
24065532-8	2013	These results demonstrate that PS successfully inhibits PKC-mediated cell migration and metastatic activities in MCF-7 ER-positive human breast cancer cells via downregulation of MMP-9 activity mediated by TIMP-1 upregulation and inhibition of aromatase and COX-2 expression.	Polysaccharides	31-33	matrix metallopeptidase 9	Homo sapiens	179-184
24065532-8	2013	These results demonstrate that PS successfully inhibits PKC-mediated cell migration and metastatic activities in MCF-7 ER-positive human breast cancer cells via downregulation of MMP-9 activity mediated by TIMP-1 upregulation and inhibition of aromatase and COX-2 expression.	Polysaccharides	31-33	TIMP metallopeptidase inhibitor 1	Homo sapiens	206-212
24065532-8	2013	These results demonstrate that PS successfully inhibits PKC-mediated cell migration and metastatic activities in MCF-7 ER-positive human breast cancer cells via downregulation of MMP-9 activity mediated by TIMP-1 upregulation and inhibition of aromatase and COX-2 expression.	Polysaccharides	31-33	prostaglandin-endoperoxide synthase 2	Homo sapiens	258-263
24065532-10	2013	In conclusion, the present investigation shows that PS may prevent COX-2- and MMP-9-mediated metastatic activities in MCF-7 ER-positive breast cancer cells through the downregulation of MAPK signaling pathways.	Polysaccharides	52-54	prostaglandin-endoperoxide synthase 2	Homo sapiens	67-72
24065532-10	2013	In conclusion, the present investigation shows that PS may prevent COX-2- and MMP-9-mediated metastatic activities in MCF-7 ER-positive breast cancer cells through the downregulation of MAPK signaling pathways.	Polysaccharides	52-54	matrix metallopeptidase 9	Homo sapiens	78-83
24065532-10	2013	In conclusion, the present investigation shows that PS may prevent COX-2- and MMP-9-mediated metastatic activities in MCF-7 ER-positive breast cancer cells through the downregulation of MAPK signaling pathways.	Polysaccharides	52-54	mitogen-activated protein kinase 1	Homo sapiens	186-190
24204277-7	2013	Neutralization by these CD4 binding site antibodies was almost entirely dependent on the glycan at position N276.	Polysaccharides	89-95	CD4 molecule	Homo sapiens	24-27
23956151-0	2013	Prediction of glycan motifs using quantitative analysis of multi-lectin binding: Motifs on MUC1 produced by cultured pancreatic cancer cells.	Polysaccharides	14-20	mucin 1, cell surface associated	Homo sapiens	91-95
24273483-1	2013	Human erythropoietin (Epo) is a 30.4 kDa glycoprotein hormone composed of a single 165 amino acid residues chain to which four glycans are attached.	Polysaccharides	127-134	erythropoietin	Homo sapiens	22-25
23926108-4	2013	In all, this study provides the first evidence of a functional role for transferrin glycans, in intracellular trafficking after uptake.	Polysaccharides	84-91	transferrin	Homo sapiens	72-83
23980712-5	2013	Moreover, our data indicate that the cell-repellent effect is dependent on mucin-associated glycans because their removal results in a loss of effective cell-repulsion.	Polysaccharides	92-99	LOC100508689	Homo sapiens	75-80
23911852-0	2013	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19+CD20+CD3-CD70-CD27+IgM+CD43+CD5+/-.	Polysaccharides	13-27	CD19 molecule	Homo sapiens	117-121
23911852-0	2013	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19+CD20+CD3-CD70-CD27+IgM+CD43+CD5+/-.	Polysaccharides	13-27	keratin 20	Homo sapiens	122-126
23911852-0	2013	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19+CD20+CD3-CD70-CD27+IgM+CD43+CD5+/-.	Polysaccharides	13-27	CD70 molecule	Homo sapiens	131-135
23911852-0	2013	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19+CD20+CD3-CD70-CD27+IgM+CD43+CD5+/-.	Polysaccharides	13-27	CD27 molecule	Homo sapiens	136-140
23911852-0	2013	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19+CD20+CD3-CD70-CD27+IgM+CD43+CD5+/-.	Polysaccharides	13-27	sialophorin	Homo sapiens	145-149
23911852-0	2013	Pneumococcal polysaccharide vaccination induces polysaccharide-specific B cells in adult peripheral blood expressing CD19+CD20+CD3-CD70-CD27+IgM+CD43+CD5+/-.	Polysaccharides	13-27	CD5 molecule	Homo sapiens	150-153
23911852-6	2013	We show that 7 days post-immunization the majority of pneumococcal polysaccharide-selected IgM(+) memory cells (PPS14(+) 56.5%, PPS23F(+) 63.8%) were CD19(+)CD20(+)CD27(+)IgM(+)CD43(+)CD5(+/-)CD70(-), which was significantly increased compared to pre-immunization levels.	Polysaccharides	67-81	CD19 molecule	Homo sapiens	150-154
23911852-6	2013	We show that 7 days post-immunization the majority of pneumococcal polysaccharide-selected IgM(+) memory cells (PPS14(+) 56.5%, PPS23F(+) 63.8%) were CD19(+)CD20(+)CD27(+)IgM(+)CD43(+)CD5(+/-)CD70(-), which was significantly increased compared to pre-immunization levels.	Polysaccharides	67-81	keratin 20	Homo sapiens	157-161
23911852-6	2013	We show that 7 days post-immunization the majority of pneumococcal polysaccharide-selected IgM(+) memory cells (PPS14(+) 56.5%, PPS23F(+) 63.8%) were CD19(+)CD20(+)CD27(+)IgM(+)CD43(+)CD5(+/-)CD70(-), which was significantly increased compared to pre-immunization levels.	Polysaccharides	67-81	CD27 molecule	Homo sapiens	164-168
23911852-6	2013	We show that 7 days post-immunization the majority of pneumococcal polysaccharide-selected IgM(+) memory cells (PPS14(+) 56.5%, PPS23F(+) 63.8%) were CD19(+)CD20(+)CD27(+)IgM(+)CD43(+)CD5(+/-)CD70(-), which was significantly increased compared to pre-immunization levels.	Polysaccharides	67-81	sialophorin	Homo sapiens	177-181
23911852-6	2013	We show that 7 days post-immunization the majority of pneumococcal polysaccharide-selected IgM(+) memory cells (PPS14(+) 56.5%, PPS23F(+) 63.8%) were CD19(+)CD20(+)CD27(+)IgM(+)CD43(+)CD5(+/-)CD70(-), which was significantly increased compared to pre-immunization levels.	Polysaccharides	67-81	CD5 molecule	Homo sapiens	184-187
23911852-6	2013	We show that 7 days post-immunization the majority of pneumococcal polysaccharide-selected IgM(+) memory cells (PPS14(+) 56.5%, PPS23F(+) 63.8%) were CD19(+)CD20(+)CD27(+)IgM(+)CD43(+)CD5(+/-)CD70(-), which was significantly increased compared to pre-immunization levels.	Polysaccharides	67-81	CD70 molecule	Homo sapiens	192-196
23911502-1	2013	Phosphorylated polysaccharide PLEP-1a, with the PO43- content of 6.39%, was prepared from LEP-1a by phosphorylation.	Polysaccharides	15-29	plasma lepin levels	Mus musculus	30-34
23911502-2	2013	IR, (13)C NMR and (31)P NMR results of PLEP-1a showed that the original basic structure of the polysaccharide was not changed, and the -H2PO3 group was linked at C6 of LEP-1a.	Polysaccharides	95-109	plasma lepin levels	Mus musculus	39-43
23867465-6	2013	Here, we identify HSPGs containing a glypican 5 core protein and 2-O-sulfo-iduronic acid residues at the nonreducing ends of the glycans as co-receptors for Shh.	Polysaccharides	129-136	sonic hedgehog signaling molecule	Homo sapiens	157-160
24039863-7	2013	Moreover, several glycans in the AAT enriched fraction were associated with physiological parameters marking cardiovascular and metabolic diseases.	Polysaccharides	18-25	serpin family A member 1	Homo sapiens	33-36
24039759-6	2013	Glyco-engineering was performed by zinc finger nuclease (ZFN) knockout (KO) of the Core 1 enzyme chaperone COSMC, thereby preventing glycan elongation beyond the initial GalNAc residue in O-linked glycans.	Polysaccharides	133-139	C1GALT1 specific chaperone 1	Homo sapiens	107-112
23866010-5	2013	However, DBP yields of polysaccharide monomers were lower than those of tested amino acids groups and the DBP yields of polysaccharide monomers were not significantly influenced by their structures.	Polysaccharides	23-37	D-box binding PAR bZIP transcription factor	Homo sapiens	9-12
23866010-5	2013	However, DBP yields of polysaccharide monomers were lower than those of tested amino acids groups and the DBP yields of polysaccharide monomers were not significantly influenced by their structures.	Polysaccharides	120-134	D-box binding PAR bZIP transcription factor	Homo sapiens	106-109
23999306-7	2013	A large glycan from a symmetry mate localizes to the active site of ST6Gal-I in an orientation compatible with catalysis.	Polysaccharides	8-14	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	68-76
23999306-8	2013	The glycan binding mode can be generalized to any glycoprotein that is a substrate of ST6Gal-I.	Polysaccharides	4-10	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	86-94
23773658-4	2013	For wild-type CFTR that exits the ER, trafficking through the Golgi is the major site for glycan processing, although nonconventional trafficking pathways have also been described for CFTR.	Polysaccharides	90-96	CF transmembrane conductance regulator	Homo sapiens	14-18
23640941-2	2013	Recent studies indicate that polysaccharide-induced autoactivation of factor XII has a role in allergy-related vascular leakage, and angioedema.	Polysaccharides	29-43	coagulation factor XII (Hageman factor)	Mus musculus	70-80
23643911-0	2013	Soft-binding ligand-capped fluorescent CdSe/ZnS quantum dots for the facile labeling of polysaccharide-based self-assemblies.	Polysaccharides	88-102	POC1 centriolar protein A	Homo sapiens	0-4
23643911-4	2013	Taking advantage of the excellent solubility of the APP-capped QDs and the soft-binding characteristics of APP, a novel reaction-free method was investigated for the fluorescent labeling of polysaccharide-based micelles via encapsulation of the intermediate QDs.	Polysaccharides	190-204	POC1 centriolar protein A	Homo sapiens	75-79
23685046-3	2013	Elemental analysis indicated that HPS4-2A was a sulfated polysaccharide containing small amount of sulfate groups (1.87%).	Polysaccharides	57-71	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2	Homo sapiens	34-38
23748008-0	2013	Liposome can improve the adjuvanticity of astragalus polysaccharide on the immune response against ovalbumin.	Polysaccharides	53-67	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	99-108
23723439-0	2013	HNK-1 sulfotransferase-dependent sulfation regulating laminin-binding glycans occurs in the post-phosphoryl moiety on alpha-dystroglycan.	Polysaccharides	70-77	carbohydrate sulfotransferase 10	Homo sapiens	0-22
23708432-7	2013	Each EPO product showed a characteristic glycoform profile with respect to sialylation, glycan size, O-acetylation of sialic acids and O-glycosylation.	Polysaccharides	88-94	erythropoietin	Homo sapiens	5-8
23811078-1	2013	The intracellular polysaccharides (CLSP) were extracted from Lepista sordida mycelium in submerged culture followed by concentration and ethanol precipitation.	Polysaccharides	18-33	calmodulin like 5	Homo sapiens	35-39
23929775-3	2013	Here, we investigate the requirements for MHC I ubiquitination and degradation and show that endogenous misfolded MHC I HCs are recognized in the ER lumen by EDEM1 in a glycan-dependent manner and targeted to the core SEL1L/HRD1/UBE2J1 complex.	Polysaccharides	169-175	ER degradation enhancing alpha-mannosidase like protein 1	Homo sapiens	158-163
23158834-13	2013	Here, we discuss the capacity of glycan-based vaccines to enhance antigen-specific CD4(+) and CD8(+) T cell responses in human skin and mouse model systems.	Polysaccharides	33-39	CD4 molecule	Homo sapiens	83-86
23158834-13	2013	Here, we discuss the capacity of glycan-based vaccines to enhance antigen-specific CD4(+) and CD8(+) T cell responses in human skin and mouse model systems.	Polysaccharides	33-39	CD8a molecule	Homo sapiens	94-97
23656330-2	2013	The beta-glucanase enzyme encoded by exoK has previously been demonstrated to cleave succinoglycan and participate in producing the low molecular weight form of this polysaccharide.	Polysaccharides	166-180	endo-1,3-1,4-beta-glycanase ExoK	Sinorhizobium meliloti 1021	37-41
23929775-3	2013	Here, we investigate the requirements for MHC I ubiquitination and degradation and show that endogenous misfolded MHC I HCs are recognized in the ER lumen by EDEM1 in a glycan-dependent manner and targeted to the core SEL1L/HRD1/UBE2J1 complex.	Polysaccharides	169-175	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase	Homo sapiens	218-223
23929775-3	2013	Here, we investigate the requirements for MHC I ubiquitination and degradation and show that endogenous misfolded MHC I HCs are recognized in the ER lumen by EDEM1 in a glycan-dependent manner and targeted to the core SEL1L/HRD1/UBE2J1 complex.	Polysaccharides	169-175	synoviolin 1	Homo sapiens	224-228
24404057-3	2013	However, the fact that 20% of VWF molecular weight originates from glycan moieties has so far been neglected in these calculations.	Polysaccharides	67-73	von Willebrand factor	Homo sapiens	30-33
23929775-3	2013	Here, we investigate the requirements for MHC I ubiquitination and degradation and show that endogenous misfolded MHC I HCs are recognized in the ER lumen by EDEM1 in a glycan-dependent manner and targeted to the core SEL1L/HRD1/UBE2J1 complex.	Polysaccharides	169-175	ubiquitin conjugating enzyme E2 J1	Homo sapiens	229-235
23824188-9	2013	The recombinant protein expressed in Escherichia coli showed epimerization activity toward substrates generated from heparin and the E. coli K5 capsular polysaccharide, thereby providing the first evidence for bacterial D-glucuronyl C5-epimerase activity.	Polysaccharides	153-167	glucuronic acid epimerase	Homo sapiens	220-245
23702291-8	2013	X-ray crystal structure analysis of glycosylated fish PAI-1 confirmed the presence of an N-linked glycan in the gate region and a lack of glycan-induced structural changes.	Polysaccharides	98-104	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	Danio rerio	54-59
23702291-9	2013	Thus, latency transition of zfPAI-1 is delayed by steric hindrance from the glycan in the gate region.	Polysaccharides	76-82	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	Danio rerio	28-35
23991039-10	2013	High-resolution analyses of trimeric Env that show the orientation of glycans and polymorphic elements of the CD4bs that affect binding to antibodies like 1F7 are desirable to understand how to promote immunogenicity of more conserved elements of the CD4bs.	Polysaccharides	70-77	endogenous retrovirus group K member 20	Homo sapiens	37-40
23940657-4	2013	For the N-sulfotransferase domain of NDST1, Lys833 has been implicated to play a role in holding the substrate glycan moiety close to the PAPS cofactor.	Polysaccharides	111-117	N-deacetylase and N-sulfotransferase 1	Homo sapiens	37-42
23937094-7	2013	In this work, in order to make full use of the high transfectivity of adenovirus, we managed to conjugate the polysaccharide mannan (polymannose) to the surface of the adenovirus chemically under appropriate oxidizing conditions to prepare the mannan-modified adenovirus (Man-Ad5-PTEN).	Polysaccharides	110-124	phosphatase and tensin homolog	Homo sapiens	280-284
23966080-7	2013	The five graded polysaccharide fractions exhibited good inhibitory power, and MTT tests in vitro showed the IC50 of PKP-A and PKP-E were 1,072.5 and 2,070.0 mug   mL-1, respectively.	Polysaccharides	16-30	L1 cell adhesion molecule	Mus musculus	163-167
23977005-3	2013	The goal of this study was to identify HCC metastasis related differential glycan pattern and their enzymatic basis using a HGF induced EMT model.	Polysaccharides	75-81	hepatocyte growth factor	Homo sapiens	124-127
23977005-9	2013	Lectin microarray analysis identified a decreased affinity in seven lectins ACL, BPL, JAC, MPL, PHA-E, SNA, and SBA to the glycan of cell surface glycoproteins.	Polysaccharides	123-129	MPL proto-oncogene, thrombopoietin receptor	Homo sapiens	91-94
23977005-11	2013	The binding ability of thirteen lectins, AAL, LCA, LTL, ConA, NML, NPL, DBA, HAL, PTL II, WFL, ECL, GSL II and PHA-L to glycan were elevated, and a definite indication that glycan containing terminal alphaFuc and +- Sia-Le, core fucose, alpha-man, gal-beta(alpha) GalNAc, beta1,6 GlcNAc branching and tetraantennary complex oligosaccharides structures were increased.	Polysaccharides	120-126	ribosomal RNA processing 8	Homo sapiens	62-65
23977005-11	2013	The binding ability of thirteen lectins, AAL, LCA, LTL, ConA, NML, NPL, DBA, HAL, PTL II, WFL, ECL, GSL II and PHA-L to glycan were elevated, and a definite indication that glycan containing terminal alphaFuc and +- Sia-Le, core fucose, alpha-man, gal-beta(alpha) GalNAc, beta1,6 GlcNAc branching and tetraantennary complex oligosaccharides structures were increased.	Polysaccharides	120-126	N-acetylneuraminate pyruvate lyase	Homo sapiens	67-70
23977005-11	2013	The binding ability of thirteen lectins, AAL, LCA, LTL, ConA, NML, NPL, DBA, HAL, PTL II, WFL, ECL, GSL II and PHA-L to glycan were elevated, and a definite indication that glycan containing terminal alphaFuc and +- Sia-Le, core fucose, alpha-man, gal-beta(alpha) GalNAc, beta1,6 GlcNAc branching and tetraantennary complex oligosaccharides structures were increased.	Polysaccharides	120-126	loss of heterozygosity, 19, chromosomal region 1	Homo sapiens	72-75
23977005-11	2013	The binding ability of thirteen lectins, AAL, LCA, LTL, ConA, NML, NPL, DBA, HAL, PTL II, WFL, ECL, GSL II and PHA-L to glycan were elevated, and a definite indication that glycan containing terminal alphaFuc and +- Sia-Le, core fucose, alpha-man, gal-beta(alpha) GalNAc, beta1,6 GlcNAc branching and tetraantennary complex oligosaccharides structures were increased.	Polysaccharides	120-126	histidine ammonia-lyase	Homo sapiens	77-80
23685052-7	2013	In addition, the assay format for the galectin-3/ASF pair could be easily applied in screening for glycan- and/or small molecule-based inhibitors of other members of the galectin family.	Polysaccharides	99-105	galectin 3	Homo sapiens	38-48
23685052-7	2013	In addition, the assay format for the galectin-3/ASF pair could be easily applied in screening for glycan- and/or small molecule-based inhibitors of other members of the galectin family.	Polysaccharides	99-105	arylsulfatase F	Homo sapiens	49-52
23940657-10	2013	In addition, the binding location of the glycan moiety, PAPS and PAP within the active site of NDST1 throughout the sulfate transfer were determined by intermediate state analysis.	Polysaccharides	41-47	N-deacetylase and N-sulfotransferase 1	Homo sapiens	95-100
23940657-11	2013	Furthermore, NDST1 mutants unveiled Lys833 as vital for both the glycan binding and subsequent N-sulfotransferase activity of NDST1.	Polysaccharides	65-71	N-deacetylase and N-sulfotransferase 1	Homo sapiens	13-18
23940657-11	2013	Furthermore, NDST1 mutants unveiled Lys833 as vital for both the glycan binding and subsequent N-sulfotransferase activity of NDST1.	Polysaccharides	65-71	N-deacetylase and N-sulfotransferase 1	Homo sapiens	126-131
23636107-5	2013	PIGT encodes phosphatidylinositol-glycan biosynthesis class T (PIG-T) protein, which is a subunit of the transamidase complex that catalyses the attachment of proteins to GPI.	Polysaccharides	34-40	phosphatidylinositol glycan anchor biosynthesis class T	Sus scrofa	0-4
23788638-0	2013	Solution NMR analyses of the C-type carbohydrate recognition domain of DC-SIGNR protein reveal different binding modes for HIV-derived oligosaccharides and smaller glycan fragments.	Polysaccharides	164-170	C-type lectin domain family 4 member M	Homo sapiens	71-79
23788638-1	2013	The C-type lectin DC-SIGNR (dendritic cell-specific ICAM-3-grabbing non-integrin-related; also known as L-SIGN or CD299) is a promising drug target due to its ability to promote infection and/or within-host survival of several dangerous pathogens (e.g. HIV and severe acute respiratory syndrome coronavirus (SARS)) via interactions with their surface glycans.	Polysaccharides	351-358	C-type lectin domain family 4 member M	Homo sapiens	18-26
23788638-1	2013	The C-type lectin DC-SIGNR (dendritic cell-specific ICAM-3-grabbing non-integrin-related; also known as L-SIGN or CD299) is a promising drug target due to its ability to promote infection and/or within-host survival of several dangerous pathogens (e.g. HIV and severe acute respiratory syndrome coronavirus (SARS)) via interactions with their surface glycans.	Polysaccharides	351-358	C-type lectin domain family 4 member M	Homo sapiens	28-88
23788638-1	2013	The C-type lectin DC-SIGNR (dendritic cell-specific ICAM-3-grabbing non-integrin-related; also known as L-SIGN or CD299) is a promising drug target due to its ability to promote infection and/or within-host survival of several dangerous pathogens (e.g. HIV and severe acute respiratory syndrome coronavirus (SARS)) via interactions with their surface glycans.	Polysaccharides	351-358	C-type lectin domain family 4 member M	Homo sapiens	104-110
23788638-1	2013	The C-type lectin DC-SIGNR (dendritic cell-specific ICAM-3-grabbing non-integrin-related; also known as L-SIGN or CD299) is a promising drug target due to its ability to promote infection and/or within-host survival of several dangerous pathogens (e.g. HIV and severe acute respiratory syndrome coronavirus (SARS)) via interactions with their surface glycans.	Polysaccharides	351-358	C-type lectin domain family 4 member M	Homo sapiens	114-119
23788638-2	2013	Crystallography has provided excellent insight into the mechanism by which DC-SIGNR interacts with small glycans, such as (GlcNAc)2Man3; however, direct observation of complexes with larger, physiological oligosaccharides, such as Man9GlcNAc2, remains elusive.	Polysaccharides	105-112	C-type lectin domain family 4 member M	Homo sapiens	75-83
23728723-0	2013	Astragalus polysaccharides suppress ICAM-1 and VCAM-1 expression in TNF-alpha-treated human vascular endothelial cells by blocking NF-kappaB activation.	Polysaccharides	11-26	intercellular adhesion molecule 1	Homo sapiens	36-42
23728723-0	2013	Astragalus polysaccharides suppress ICAM-1 and VCAM-1 expression in TNF-alpha-treated human vascular endothelial cells by blocking NF-kappaB activation.	Polysaccharides	11-26	vascular cell adhesion molecule 1	Homo sapiens	47-53
23728723-0	2013	Astragalus polysaccharides suppress ICAM-1 and VCAM-1 expression in TNF-alpha-treated human vascular endothelial cells by blocking NF-kappaB activation.	Polysaccharides	11-26	tumor necrosis factor	Homo sapiens	68-77
23580236-6	2013	Increased level of alpha1-6 fucosylated tri-antennary glycans was found in all disease groups compared to the control.	Polysaccharides	54-61	adrenoceptor alpha 1D	Homo sapiens	19-27
23637070-4	2013	Here, we present glyXalign, a freely available and easy-to-use software package to automatically correct for distortions in xCGE-LIF based glycan data.	Polysaccharides	139-145	LIF interleukin 6 family cytokine	Homo sapiens	129-132
23623843-1	2013	This study was designed to investigate chemical characterization of the water-soluble polysaccharides extracted from Keemun black tea (KBTP), and their antioxidant and hepatoprotective effects against CCl4-induced oxidative damage in mice.	Polysaccharides	86-101	chemokine (C-C motif) ligand 4	Mus musculus	201-205
23640779-8	2013	Intriguingly, the O-glycosylation of the shed MUC1 ectodomain subunit changes from preponderant sialylated core 1 (MUC1-M) to core 2 glycans on the non-recycling CQC/AQA mutant.	Polysaccharides	133-140	mucin 1, cell surface associated	Homo sapiens	46-50
23640779-11	2013	Differential radiolabeling of protein with [(35)S]Met/Cys or glycans with [(3)H]GlcNH2 in pulse-chase experiments of surface biotinylated MUC1 revealed a significantly shorter half-life of [(3)H]MUC1 when compared with [(35)S]MUC1, whereas the same ratio for the CQC/AQA mutant was close to one.	Polysaccharides	61-68	mucin 1, cell surface associated	Homo sapiens	138-142
23788638-5	2013	In particular, our data show that DC-SIGNR has a different binding mode for glycans on the HIV viral envelope compared with the smaller glycans previously observed in the crystalline state.	Polysaccharides	76-83	C-type lectin domain family 4 member M	Homo sapiens	34-42
23788638-5	2013	In particular, our data show that DC-SIGNR has a different binding mode for glycans on the HIV viral envelope compared with the smaller glycans previously observed in the crystalline state.	Polysaccharides	136-143	C-type lectin domain family 4 member M	Homo sapiens	34-42
23788638-6	2013	This suggests that using the binding mode of Man9GlcNAc, instead of those of small glycans, may provide a platform for the design of DC-SIGNR inhibitors selective for high mannose glycans (like those on HIV).	Polysaccharides	83-90	C-type lectin domain family 4 member M	Homo sapiens	133-141
23788638-7	2013	(15)N relaxation measurements provided the first information on the dynamics of the carbohydrate recognition domain, demonstrating that it is a highly flexible domain that undergoes ligand-induced conformational and dynamic changes that may explain the ability of DC-SIGNR to accommodate a range of glycans on viral surfaces.	Polysaccharides	299-306	C-type lectin domain family 4 member M	Homo sapiens	264-272
23829323-0	2013	Exploring site-specific N-glycosylation microheterogeneity of haptoglobin using glycopeptide CID tandem mass spectra and glycan database search.	Polysaccharides	121-127	haptoglobin	Homo sapiens	62-73
23188459-8	2013	With this study, we demonstrate that the glycan structures of AtDIR6 are essential for structure, solubility, and function of the protein as deglycosylation induced conformational changes leading to the complete loss in dirigent activity and subsequent protein aggregation.	Polysaccharides	41-47	Disease resistance-responsive (dirigent-like protein) family protein	Arabidopsis thaliana	62-68
23895096-1	2013	Pradimicins (PRM) are a unique class of nonpeptidic carbohydrate-binding agents that inhibit HIV infection by efficiently binding to the HIV-1 envelope gp120 glycans in the obligatory presence of Ca(2+).	Polysaccharides	158-165	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	152-157
23895096-6	2013	However, Zn(2+), Mg(2+) and Mn(2+) added to a Ca(2+)- pradimicin mixture, prevented pradimicin from efficient binding to gp120 glycans.	Polysaccharides	127-134	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	121-126
23895096-8	2013	Thus, in order to afford antiviral activity, only a few cations can (i) bind to pradimicin to form a dimeric complex and (ii) subsequently coordinate the pradimicin/cation interaction with gp120 glycans.	Polysaccharides	195-202	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	189-194
24818172-4	2013	Bovine milk is a source of a wide array of known bioactive compounds from a variety of molecular classes, including free glycans, lipids, glycolipids, peptides, proteins, glycoproteins, stem cells and microRNA.	Polysaccharides	121-128	Weaning weight-maternal milk	Bos taurus	7-11
23728389-9	2013	Our findings demonstrate that AtAPY6 and AtAPY7 are enzymes that play an important role in exine development of pollen grains, possibly through regulating the production of key polysaccharides needed for proper assembly of the exine layer.	Polysaccharides	177-192	GDA1/CD39 nucleoside phosphatase family protein	Arabidopsis thaliana	30-36
23728389-9	2013	Our findings demonstrate that AtAPY6 and AtAPY7 are enzymes that play an important role in exine development of pollen grains, possibly through regulating the production of key polysaccharides needed for proper assembly of the exine layer.	Polysaccharides	177-192	GDA1/CD39 nucleoside phosphatase family protein	Arabidopsis thaliana	41-47
23485726-0	2013	Protein-bound polysaccharide decreases invasiveness and proliferation in pancreatic cancer by inhibition of hedgehog signaling and HIF-1alpha pathways under hypoxia.	Polysaccharides	14-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-141
23831758-1	2013	A new class of glycan-reactive HIV-neutralizing antibodies, including PG9 and PG16, has been recently discovered that seem to recognize previously uncharacterized glycopeptide epitopes on HIV-1 gp120.	Polysaccharides	15-21	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	194-199
23874792-8	2013	These data indicate that binding of the CD4bs specific HJ16 mAb critically depends on the interaction with the N276-glycan, thus indicating that HJ16 is the first glycan dependent CD4bs-specific mAb.	Polysaccharides	116-122	CD4 molecule	Homo sapiens	40-43
23754284-6	2013	By use of a glycan library in both array and solution formats, we were able to reveal that FUT-6, another C. elegans alpha1,3-fucosyltransferase, modifies nematode glycan cores, specifically the distal N-acetylglucosamine residue; this result is in accordance with glycomic analysis of fut-6 mutant worms.	Polysaccharides	12-18	Alpha-(1,3)-fucosyltransferase fut-6	Caenorhabditis elegans	91-96
23754284-6	2013	By use of a glycan library in both array and solution formats, we were able to reveal that FUT-6, another C. elegans alpha1,3-fucosyltransferase, modifies nematode glycan cores, specifically the distal N-acetylglucosamine residue; this result is in accordance with glycomic analysis of fut-6 mutant worms.	Polysaccharides	12-18	Alpha-(1,3)-fucosyltransferase fut-6	Caenorhabditis elegans	286-291
23754284-6	2013	By use of a glycan library in both array and solution formats, we were able to reveal that FUT-6, another C. elegans alpha1,3-fucosyltransferase, modifies nematode glycan cores, specifically the distal N-acetylglucosamine residue; this result is in accordance with glycomic analysis of fut-6 mutant worms.	Polysaccharides	164-170	Alpha-(1,3)-fucosyltransferase fut-6	Caenorhabditis elegans	91-96
23754284-9	2013	FUT-6 is probably the first eukaryotic glycosyltransferase whose specificity has been redefined with the aid of glycan microarrays and so is a paradigm for the study of other unusual glycosidic linkages in model and parasitic organisms.	Polysaccharides	112-118	Alpha-(1,3)-fucosyltransferase fut-6	Caenorhabditis elegans	0-5
23894366-1	2013	Our group has shown that the polysaccharides extracted from Lycium barbarum (LBP) are neuroprotective for retinal ganglion cells (RGCs) in different animal models.	Polysaccharides	29-44	lipopolysaccharide binding protein	Rattus norvegicus	77-80
23632321-0	2013	Anti-tumor effects in mice induced by survivin-targeted siRNA delivered through polysaccharide nanoparticles.	Polysaccharides	80-94	baculoviral IAP repeat-containing 5	Mus musculus	38-46
23740650-1	2013	From the stacks: A novel method for construction of a high-mannose-type glycan library by systematic enzymatic trimming of a single synthetic Man9-based precursor was developed.	Polysaccharides	72-78	mannosidase alpha class 1A member 1	Homo sapiens	142-146
23775885-1	2013	The total synthesis of a homogeneous erythropoietin (EPO), possessing the native amino acid sequence and chitobiose glycans at each of the three wild-type sites of N glycosylation, has been accomplished in our laboratory.	Polysaccharides	116-123	erythropoietin	Homo sapiens	37-51
23775885-1	2013	The total synthesis of a homogeneous erythropoietin (EPO), possessing the native amino acid sequence and chitobiose glycans at each of the three wild-type sites of N glycosylation, has been accomplished in our laboratory.	Polysaccharides	116-123	erythropoietin	Homo sapiens	53-56
23709226-5	2013	To understand the biochemical basis and regulation of LMAN1 binding to glycoprotein cargo, we solved crystal structures of the LMAN1-CRD bound to Man-alpha-1,2-Man, the terminal carbohydrate moiety of high mannose glycans.	Polysaccharides	214-221	lectin, mannose binding 1	Homo sapiens	54-59
23703791-0	2013	A bioorthogonal Raman reporter strategy for SERS detection of glycans on live cells.	Polysaccharides	62-69	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	44-48
23751344-6	2013	Further, we assessed the inhibitory effect of Galbeta1-4Fuc, Galbeta1-4Glc, and Gal on the interaction between hGal-1 and its model ligand glycan, and found that Galbeta1-4Fuc is the most effective.	Polysaccharides	139-145	galectin 1	Homo sapiens	111-117
23745692-2	2013	The Fc glycan modulates biological effector functions, including antibody-dependent cellular cytotoxicity (ADCC) which is mediated in part through the activatory Fc receptor, FcgammaRIIIA.	Polysaccharides	7-13	Fc gamma receptor IIIa	Homo sapiens	175-187
23745692-5	2013	Given that sialylation of Fc glycans decreases ADCC, one explanation for the effect of these mutants on FcgammaRIIIA binding is their increased sialylation.	Polysaccharides	29-36	Fc gamma receptor IIIa	Homo sapiens	104-116
23745692-6	2013	However, a glycan-engineered IgG1 with hypergalactosylated and hypersialylated glycans exhibited unchanged binding affinity to FcgammaRIIIA.	Polysaccharides	11-17	Fc gamma receptor IIIa	Homo sapiens	127-139
23520133-3	2013	Insulin binding to its receptor rapidly induces interaction of the receptor with Neu1, which hydrolyzes sialic acid residues in the glycan chains of the receptor and, consequently, induces its activation.	Polysaccharides	132-138	insulin	Homo sapiens	0-7
23520133-3	2013	Insulin binding to its receptor rapidly induces interaction of the receptor with Neu1, which hydrolyzes sialic acid residues in the glycan chains of the receptor and, consequently, induces its activation.	Polysaccharides	132-138	neuraminidase 1	Homo sapiens	81-85
23463814-3	2013	Liquid chromatography mass spectrometry (LC-MS) of O-glycans released from PSGL-1/mIgG2b revealed a large repertoire of structurally diverse glycans, which is in contrast to previous reports of only simple glycans.	Polysaccharides	53-60	immunoglobulin heavy constant gamma 2B	Mus musculus	82-88
23542315-6	2013	The results demonstrated that F8A1.1 recognized glycans expressing Le(x) epitopes in a terminal nonreducing position, whereas anti-CD15 bound to glycans with multiple repeats of Le(x) epitopes, but not to glycans with a single, terminal Le(x) epitope.	Polysaccharides	145-152	fucosyltransferase 4	Homo sapiens	131-135
23542315-6	2013	The results demonstrated that F8A1.1 recognized glycans expressing Le(x) epitopes in a terminal nonreducing position, whereas anti-CD15 bound to glycans with multiple repeats of Le(x) epitopes, but not to glycans with a single, terminal Le(x) epitope.	Polysaccharides	145-152	fucosyltransferase 4	Homo sapiens	131-135
23463814-3	2013	Liquid chromatography mass spectrometry (LC-MS) of O-glycans released from PSGL-1/mIgG2b revealed a large repertoire of structurally diverse glycans, which is in contrast to previous reports of only simple glycans.	Polysaccharides	141-148	immunoglobulin heavy constant gamma 2B	Mus musculus	82-88
23507963-2	2013	In the present study, we have analyzed the carbohydrate specificity of the C-type lectin CLEC10A using glycan profiling by enzyme-linked immunosorbent assay (ELISA).	Polysaccharides	103-109	C-type lectin domain containing 10A	Homo sapiens	89-96
23633012-7	2013	The glycans were enzymatically released, purified, and finally analyzed by MALDI-TOF-MS. To simulate changes to glycan profiles after administration in vivo, a therapeutic antibody was incubated in serum with the enzyme alpha1-2,3 mannosidase to artificially reduce the amount of the high mannose glycoforms.	Polysaccharides	4-11	adrenoceptor alpha 1D	Homo sapiens	220-228
23782552-7	2013	Moreover, antibiotics altered the active fraction of enzymes controlling the thickness, composition and consistency of the mucin glycans.	Polysaccharides	129-136	LOC100508689	Homo sapiens	123-128
23722906-3	2013	Here we show that liposomal nanoparticles, displaying both antigen and glycan ligands of the inhibitory coreceptor CD22, induce a tolerogenic program that selectively causes apoptosis in mouse and human B cells.	Polysaccharides	71-77	CD22 antigen	Mus musculus	115-119
23613470-7	2013	Mass-spectrometric analyses revealed that Wnt11 is modified with complex/hybrid(Asn40)-, high-mannose(Asn90)- and high-mannose/hybrid(Asn300)-type glycans and that Wnt3a is modified with two high-mannose-type glycans (Asn87 and Asn298).	Polysaccharides	147-154	Wnt family member 11	Homo sapiens	42-47
23613470-7	2013	Mass-spectrometric analyses revealed that Wnt11 is modified with complex/hybrid(Asn40)-, high-mannose(Asn90)- and high-mannose/hybrid(Asn300)-type glycans and that Wnt3a is modified with two high-mannose-type glycans (Asn87 and Asn298).	Polysaccharides	209-216	Wnt family member 11	Homo sapiens	42-47
23613470-7	2013	Mass-spectrometric analyses revealed that Wnt11 is modified with complex/hybrid(Asn40)-, high-mannose(Asn90)- and high-mannose/hybrid(Asn300)-type glycans and that Wnt3a is modified with two high-mannose-type glycans (Asn87 and Asn298).	Polysaccharides	209-216	Wnt family member 3A	Homo sapiens	164-169
23567825-8	2013	Moreover, specific changes of GlcNAc abundances in Annexin A1 and HSP90beta suggested that tumor-specific glycan patterns could serve as candidate biomarkers of colon cancer for distinguishing cancer patients from healthy individuals.	Polysaccharides	106-112	annexin A1	Homo sapiens	51-61
23065139-5	2013	N-glycan profiles revealed that rAT contained 10 glycan structures ranging from bi-antennary to tetra-antennary complex-type glycans while nAT displayed six peaks comprising majorly bi-antennary glycans and a small portion of tri-antennary glycans.	Polysaccharides	195-202	N-acetyltransferase 1	Rattus norvegicus	139-142
23065139-5	2013	N-glycan profiles revealed that rAT contained 10 glycan structures ranging from bi-antennary to tetra-antennary complex-type glycans while nAT displayed six peaks comprising majorly bi-antennary glycans and a small portion of tri-antennary glycans.	Polysaccharides	195-202	N-acetyltransferase 1	Rattus norvegicus	139-142
23065139-6	2013	In addition, most of the rAT glycans were shown to have only core alpha(1 - 6)-fucose without terminal fucosylation, whereas only minor portions of the nAT glycans contained core or Lewis X-type fucose.	Polysaccharides	156-163	N-acetyltransferase 1	Rattus norvegicus	152-155
23203627-7	2013	Analysis of active ingredients indicates that polysaccharide-containing macromolecules in TJ-41 contribute to the enhancement of CCL20 mRNA expression through an intracellular signal cascade via nuclear factor kappa B (NF-kappaB) activation.	Polysaccharides	46-60	chemokine (C-C motif) ligand 20	Mus musculus	129-134
23203627-7	2013	Analysis of active ingredients indicates that polysaccharide-containing macromolecules in TJ-41 contribute to the enhancement of CCL20 mRNA expression through an intracellular signal cascade via nuclear factor kappa B (NF-kappaB) activation.	Polysaccharides	46-60	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	195-217
23203627-7	2013	Analysis of active ingredients indicates that polysaccharide-containing macromolecules in TJ-41 contribute to the enhancement of CCL20 mRNA expression through an intracellular signal cascade via nuclear factor kappa B (NF-kappaB) activation.	Polysaccharides	46-60	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	219-228
23567825-8	2013	Moreover, specific changes of GlcNAc abundances in Annexin A1 and HSP90beta suggested that tumor-specific glycan patterns could serve as candidate biomarkers of colon cancer for distinguishing cancer patients from healthy individuals.	Polysaccharides	106-112	heat shock protein 90 alpha family class B member 1	Homo sapiens	66-75
24417139-0	2013	[Influence of different preparation on the content of carbohydrate and physicochemical properties of polysaccharides from raw paeoniae radix alba and stir-baked paeoniae radix alba].	Polysaccharides	101-116	afamin	Homo sapiens	141-145
24417139-7	2013	Different preparation has significant impact on the yield and the content of carbohydrate in Paeoniae Radix Alba by stir-baked method, and it can decrease the dissolution of polysaccharide.	Polysaccharides	174-188	afamin	Homo sapiens	108-112
23708606-1	2013	A substantial proportion of the broadly neutralizing antibodies (bnAbs) identified in certain HIV-infected donors recognize glycan-dependent epitopes on HIV-1 gp120.	Polysaccharides	124-130	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	159-164
23708606-3	2013	PGT 135 interacts with glycans at Asn332, Asn392 and Asn386, using long CDR loops H1 and H3 to penetrate the glycan shield and access the gp120 protein surface.	Polysaccharides	23-30	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	138-143
23708606-4	2013	EM reveals that PGT 135 can accommodate the conformational and chemical diversity of gp120 glycans by altering its angle of engagement.	Polysaccharides	91-98	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	85-90
23930009-3	2013	OBJECTIVE: To investigate the anti-microorganism, anti-tumor, and immune activities of a novel polysaccharide (TMP-A) isolated from Tricholoma matsutake.	Polysaccharides	95-109	tropomyosin 1, alpha	Mus musculus	111-116
23930009-4	2013	MATERIALS AND METHODS: The anti-microorganism activity of purified polysaccharides (TMP-A) was evaluated by the inhibition zone diameter, the anti-tumor activity was evaluated by the S180 tumor cells that were implanted subcutaneously into the Kunming strain male mice in vivo, and the immune activity was evaluated by lymphocyte proliferation and macrophage stimulation, respectively.	Polysaccharides	67-82	tropomyosin 1, alpha	Mus musculus	84-89
24417139-0	2013	[Influence of different preparation on the content of carbohydrate and physicochemical properties of polysaccharides from raw paeoniae radix alba and stir-baked paeoniae radix alba].	Polysaccharides	101-116	afamin	Homo sapiens	176-180
23701871-7	2013	Finally, several mutants of endo-alpha-mannosidase were produced and their affinities to monoglucosylated glycans were evaluated.	Polysaccharides	106-113	mannosidase endo-alpha	Homo sapiens	28-50
24417139-1	2013	OBJECTIVE: To observe the difference of two preparation methods on the content of carbohydrate and physicochemical properties of polysaccharides from raw Paeoniae Radix Alba and stir-baked Paeoniae Radix Alba.	Polysaccharides	129-144	afamin	Homo sapiens	169-173
24417139-1	2013	OBJECTIVE: To observe the difference of two preparation methods on the content of carbohydrate and physicochemical properties of polysaccharides from raw Paeoniae Radix Alba and stir-baked Paeoniae Radix Alba.	Polysaccharides	129-144	afamin	Homo sapiens	204-208
24417139-2	2013	METHODS: Polysaccharides extracted from raw Paeoniae Radix Alba and stir-baked Paeoniae Radix Alba with water were precipitated by ethanol and named as BSEP-S and BSEP-C, respectively.	Polysaccharides	9-24	afamin	Homo sapiens	59-63
24417139-2	2013	METHODS: Polysaccharides extracted from raw Paeoniae Radix Alba and stir-baked Paeoniae Radix Alba with water were precipitated by ethanol and named as BSEP-S and BSEP-C, respectively.	Polysaccharides	9-24	ATP binding cassette subfamily B member 11	Homo sapiens	152-156
24417139-2	2013	METHODS: Polysaccharides extracted from raw Paeoniae Radix Alba and stir-baked Paeoniae Radix Alba with water were precipitated by ethanol and named as BSEP-S and BSEP-C, respectively.	Polysaccharides	9-24	ATP binding cassette subfamily B member 11	Homo sapiens	163-167
23763610-2	2013	Here, we describe the design and construction of peptide-free multivalent glycosylated nanoscale constructs as potential synthetic cancer vaccines that generate significant titers of antibodies selective for aberrant mucin glycans.	Polysaccharides	223-230	LOC100508689	Homo sapiens	217-222
23805230-1	2013	BACKGROUND: The meningococcal serogroup A (MenA) polysaccharide conjugate vaccine used in Sub-Saharan Africa does not prevent disease caused by MenW or MenX strains, which also cause epidemics in the region.	Polysaccharides	49-63	ENAH actin regulator	Homo sapiens	43-47
23805213-1	2013	It is generally accepted that human influenza viruses bind glycans containing sialic acid linked alpha2-6 to the next sugar, that avian influenza viruses bind glycans containing the alpha2-3 linkage, and that mutations that change the binding specificity might change the host tropism.	Polysaccharides	59-66	immunoglobulin binding protein 1	Homo sapiens	97-105
23675869-0	2013	Attomolar detection of influenza A virus hemagglutinin human H1 and avian H5 using glycan-blotted field effect transistor biosensor.	Polysaccharides	83-89	H1.5 linker histone, cluster member	Homo sapiens	61-76
23824659-1	2013	Galectin-4 (Gal-4) is a member of the galectin family of glycan binding proteins that shows a significantly higher expression in cystic tumors of the human pancreas and in pancreatic adenocarcinomas compared to normal pancreas.	Polysaccharides	57-63	galectin 4	Homo sapiens	0-10
23671108-2	2013	IgG with modification of the heavy-chain glycan on asparagine 297 by the streptococcal enzyme endo-beta-N-acetylglucosaminidase (EndoS) induced a dominant suppression of immune complex (IC)-mediated inflammation, such as arthritis, through destabilization of local ICs by fragment crystallizable-fragment crystallizable (Fc-Fc) interactions.	Polysaccharides	41-47	endo-beta-N-acetylglucosaminidase	Mus musculus	94-127
23824659-1	2013	Galectin-4 (Gal-4) is a member of the galectin family of glycan binding proteins that shows a significantly higher expression in cystic tumors of the human pancreas and in pancreatic adenocarcinomas compared to normal pancreas.	Polysaccharides	57-63	galectin 4	Homo sapiens	12-17
23618233-5	2013	SF-2 displayed the highest antioxidant activity among the polysaccharides.	Polysaccharides	58-73	serine and arginine rich splicing factor 1	Homo sapiens	0-4
23776650-3	2013	Little is known on the glycan specificity and ligands of the Dendritic Cell Immunoreceptor (DCIR), the only classical C-type lectin that contains an intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM).	Polysaccharides	23-29	C-type lectin domain family 4 member A	Homo sapiens	61-90
23776650-3	2013	Little is known on the glycan specificity and ligands of the Dendritic Cell Immunoreceptor (DCIR), the only classical C-type lectin that contains an intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM).	Polysaccharides	23-29	C-type lectin domain family 4 member A	Homo sapiens	92-96
23776650-4	2013	Here we show that purified DCIR binds the glycan structures Lewis(b) and Man3.	Polysaccharides	42-48	C-type lectin domain family 4 member A	Homo sapiens	27-31
23776650-6	2013	Since DCIR has an N-glycosylation site inside its carbohydrate recognition domain (CRD), we investigated the effect of this glycan in ligand recognition.	Polysaccharides	124-130	C-type lectin domain family 4 member A	Homo sapiens	6-10
23776650-7	2013	Removing or truncating the glycans present on purified DCIR increased the affinity for DCIR-binding glycans.	Polysaccharides	27-34	C-type lectin domain family 4 member A	Homo sapiens	55-59
23776650-7	2013	Removing or truncating the glycans present on purified DCIR increased the affinity for DCIR-binding glycans.	Polysaccharides	27-34	C-type lectin domain family 4 member A	Homo sapiens	87-91
23776650-7	2013	Removing or truncating the glycans present on purified DCIR increased the affinity for DCIR-binding glycans.	Polysaccharides	100-107	C-type lectin domain family 4 member A	Homo sapiens	55-59
23776650-7	2013	Removing or truncating the glycans present on purified DCIR increased the affinity for DCIR-binding glycans.	Polysaccharides	100-107	C-type lectin domain family 4 member A	Homo sapiens	87-91
23776650-9	2013	In contrast, cis and trans interactions with glycans induced DCIR mediated signaling, resulting in a decreased phosphorylation of the ITIM sequence.	Polysaccharides	45-52	C-type lectin domain family 4 member A	Homo sapiens	61-65
23776650-10	2013	These results show that glycan binding to DCIR is influenced by the glycosylation of the CRD region in DCIR and that interaction with its ligands result in signaling via its ITIM motif.	Polysaccharides	24-30	C-type lectin domain family 4 member A	Homo sapiens	42-46
23776650-10	2013	These results show that glycan binding to DCIR is influenced by the glycosylation of the CRD region in DCIR and that interaction with its ligands result in signaling via its ITIM motif.	Polysaccharides	24-30	C-type lectin domain family 4 member A	Homo sapiens	103-107
23762286-7	2013	While CLEC4F has strong binding to Gal and GalNAc, terminal fucosylation inhibits CLEC4F recognition to several glycans such as Fucosyl GM1, Globo H, Bb3~4 and other fucosyl-glycans.	Polysaccharides	112-119	C-type lectin domain family 4, member f	Mus musculus	82-88
23497867-0	2013	AKT signalling and mitochondrial pathways are involved in mushroom polysaccharide-induced apoptosis and G1 or S phase arrest in human hepatoma cells.	Polysaccharides	67-81	AKT serine/threonine kinase 1	Homo sapiens	0-3
23497867-2	2013	The results show that regarding cell cycle-related proteins, three types of polysaccharides significantly enhance the expression of p27(Kip) in HepG2 and Bel-7404 cells, while suppressing the activity of cyclin D1/CDK4 and/or cyclin E/CDK2.	Polysaccharides	76-91	interferon alpha inducible protein 27	Homo sapiens	132-135
23497867-2	2013	The results show that regarding cell cycle-related proteins, three types of polysaccharides significantly enhance the expression of p27(Kip) in HepG2 and Bel-7404 cells, while suppressing the activity of cyclin D1/CDK4 and/or cyclin E/CDK2.	Polysaccharides	76-91	cyclin D1	Homo sapiens	204-213
23497867-2	2013	The results show that regarding cell cycle-related proteins, three types of polysaccharides significantly enhance the expression of p27(Kip) in HepG2 and Bel-7404 cells, while suppressing the activity of cyclin D1/CDK4 and/or cyclin E/CDK2.	Polysaccharides	76-91	cyclin dependent kinase 4	Homo sapiens	214-218
23497867-2	2013	The results show that regarding cell cycle-related proteins, three types of polysaccharides significantly enhance the expression of p27(Kip) in HepG2 and Bel-7404 cells, while suppressing the activity of cyclin D1/CDK4 and/or cyclin E/CDK2.	Polysaccharides	76-91	cyclin dependent kinase 2	Homo sapiens	235-239
23497867-3	2013	Considering apoptosis-related factors, the polysaccharides suppressed AKT activity through the inhibition of AKT phosphorylation at Thr(308) and/or Ser(473).	Polysaccharides	43-58	AKT serine/threonine kinase 1	Homo sapiens	70-73
23497867-3	2013	Considering apoptosis-related factors, the polysaccharides suppressed AKT activity through the inhibition of AKT phosphorylation at Thr(308) and/or Ser(473).	Polysaccharides	43-58	AKT serine/threonine kinase 1	Homo sapiens	109-112
23497867-5	2013	The polysaccharides also activated the mitochondria-mediated apoptosis pathway by stimulating the activation of Bcl-2 family proteins to release cytochrome c and Smac and cleave caspase-9 and caspase-3 in HepG2 and Bel-7404 cells.	Polysaccharides	4-19	cytochrome c, somatic	Homo sapiens	145-157
23497867-5	2013	The polysaccharides also activated the mitochondria-mediated apoptosis pathway by stimulating the activation of Bcl-2 family proteins to release cytochrome c and Smac and cleave caspase-9 and caspase-3 in HepG2 and Bel-7404 cells.	Polysaccharides	4-19	diablo IAP-binding mitochondrial protein	Homo sapiens	162-166
23497867-5	2013	The polysaccharides also activated the mitochondria-mediated apoptosis pathway by stimulating the activation of Bcl-2 family proteins to release cytochrome c and Smac and cleave caspase-9 and caspase-3 in HepG2 and Bel-7404 cells.	Polysaccharides	4-19	caspase 9	Homo sapiens	178-187
23497867-5	2013	The polysaccharides also activated the mitochondria-mediated apoptosis pathway by stimulating the activation of Bcl-2 family proteins to release cytochrome c and Smac and cleave caspase-9 and caspase-3 in HepG2 and Bel-7404 cells.	Polysaccharides	4-19	caspase 3	Homo sapiens	192-201
23611437-0	2013	Crystal structure of the capsular polysaccharide synthesizing protein CapE of Staphylococcus aureus.	Polysaccharides	34-48	structural maintenance of chromosomes 2	Homo sapiens	70-74
23611437-8	2013	Structural and primary sequence alignment identifies a group of SDR proteins involved in polysaccharide synthesis that share the two salient features of CapE: the mobile loop (latch) and a distinctive catalytic site (MxxxK).	Polysaccharides	89-103	structural maintenance of chromosomes 2	Homo sapiens	153-157
23586857-5	2013	Detailed analysis of SSO1273, one of the most abundant ABC transporters present in the cell surface fraction of S. solfataricus, revealed a novel glycan structure composed of a branched sulfated heptasaccharide, Hex4(GlcNAc)2 plus sulfoquinovose where Hex is d-mannose and d-glucose.	Polysaccharides	146-152	ABC transporter substrate-binding protein	Saccharolobus solfataricus P2	21-28
23618270-0	2013	A chemically sulfated polysaccharide from Grifola frondos induces HepG2 cell apoptosis by notch1-NF-kappaB pathway.	Polysaccharides	22-36	notch receptor 1	Homo sapiens	90-96
23618270-0	2013	A chemically sulfated polysaccharide from Grifola frondos induces HepG2 cell apoptosis by notch1-NF-kappaB pathway.	Polysaccharides	22-36	nuclear factor kappa B subunit 1	Homo sapiens	97-106
23616304-2	2013	P30-conjugated glycopeptide vaccines containing three glycans in the immunodominant motifs PDTRP and GSTAP induced much stronger immune responses and complement dependent cytotoxicity mediated killing of tumor cells when applied in plain PBS solution without complete Freund"s adjuvant.	Polysaccharides	54-61	centromere protein V	Homo sapiens	0-3
23583650-3	2013	We previously demonstrated that fibroblasts stimulated with IL-1beta increased their generation of the polysaccharide hyaluronan (HA) and increased their expression of the HA synthase enzyme (HAS-2).	Polysaccharides	103-117	interleukin 1 beta	Homo sapiens	60-68
23552399-0	2013	Heterozygous mis-sense mutations in Prkcb as a critical determinant of anti-polysaccharide antibody formation.	Polysaccharides	76-90	protein kinase C beta	Homo sapiens	36-41
23554468-7	2013	According to our results, both conjugation processes reduced the alpha-helical content of rPspA; reduction was more pronounced when the reaction between the polysaccharide capsule and rPspA1 was promoted between the carboxyl groups than the amine groups (46% and 13%, respectively).	Polysaccharides	157-171	surfactant protein A1	Rattus norvegicus	90-95
23552399-6	2013	These results, coupled with evidence of numerous mis-sense PRKCB mutations in the human genome, identify Prkcb as a genetically sensitive step likely to contribute substantially to population variability in anti-polysaccharide antibody levels.	Polysaccharides	212-226	protein kinase C beta	Homo sapiens	59-64
23552399-6	2013	These results, coupled with evidence of numerous mis-sense PRKCB mutations in the human genome, identify Prkcb as a genetically sensitive step likely to contribute substantially to population variability in anti-polysaccharide antibody levels.	Polysaccharides	212-226	protein kinase C beta	Homo sapiens	105-110
23858973-2	2013	In the present work, we report on the development of rifampicin (RIF)-loaded nanoparticles and flower-like polymeric micelles surface-modified with hydrolyzed galatomannan (GalM-h), a polysaccharide of mannose and galactose, two sugars that are recognized by lectin-like receptors.	Polysaccharides	184-198	galactose mutarotase	Mus musculus	173-177
23760703-5	2013	Recently, genomewide association studies have resulted in the identification of C-reactive protein and glycan profile as specific biomarkers for the most common MODY subtype due to HNF1A mutations, and the potential translation of these findings are discussed.	Polysaccharides	103-109	HNF1 homeobox A	Homo sapiens	181-186
23548905-6	2013	Overexpression of glycoprotein-specific ST6GalNAc-transferases (ST6GalNAc1, -2, or -4) in human promyelocytic HL-60 cells altered glycan structures and cell adhesion properties.	Polysaccharides	130-136	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1	Homo sapiens	64-85
23716574-10	2013	Spatiotemporal data of the phylotype"s distribution within the Baltic Sea indicate a connection to Cyanobacteria that may be the main source of the polysaccharide substrates.	Polysaccharides	148-162	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	70-73
23589287-3	2013	Our previous studies show that fibroblast differentiation in response to TGF-beta1 is dependent on and mediated by the linear polysaccharide hyaluronan (HA).	Polysaccharides	126-140	transforming growth factor beta 1	Homo sapiens	73-82
23584042-2	2013	The most abundant free glycan was disialo-biantennary glycan typically observed in transferrin which is one of the abundant glycoproteins found in sera.	Polysaccharides	23-29	transferrin	Homo sapiens	83-94
23584042-2	2013	The most abundant free glycan was disialo-biantennary glycan typically observed in transferrin which is one of the abundant glycoproteins found in sera.	Polysaccharides	54-60	transferrin	Homo sapiens	83-94
23584042-3	2013	Minor glycans were also considered to be mainly due to transferrin, but some glycans were derived from mucin-type O-glycans, although the amount was quite minute.	Polysaccharides	6-13	transferrin	Homo sapiens	55-66
23354723-1	2013	The glycan polysialic acid is well-known as a unique posttranslational modification of the neural cell adhesion molecule NCAM.	Polysaccharides	4-10	neural cell adhesion molecule 1	Homo sapiens	121-125
23171684-1	2013	Sialic acid immunoglobulin-like lectin (Siglec)-6 is a transmembrane receptor that binds sialyl-TN glycans and leptin.	Polysaccharides	99-106	sialic acid binding Ig like lectin 6	Homo sapiens	0-49
24006666-14	2013	can suppress NAFLD induced upregulation of blood sugar, serum insulin, insulin resistance in- dex and serum and hepatic IL-18 levels in fatty liver rats, which may contribute to its effect in relieving polysaccharide attack induced liver damage.	Polysaccharides	202-216	interleukin 18	Rattus norvegicus	120-125
23717436-4	2013	A dual stimulation of protein-bound polysaccharides isolated from Coriolus versicolor (TLR2 agonist) and penicillin-inactivated Streptococcus pyogenes (TLR4 agonist) led human monocyte-derived DCs to produce HSP90alpha and multiple cytokines such as IL-12p70 and IL-10.	Polysaccharides	36-51	heat shock protein 90 alpha family class A member 1	Homo sapiens	208-218
23717436-4	2013	A dual stimulation of protein-bound polysaccharides isolated from Coriolus versicolor (TLR2 agonist) and penicillin-inactivated Streptococcus pyogenes (TLR4 agonist) led human monocyte-derived DCs to produce HSP90alpha and multiple cytokines such as IL-12p70 and IL-10.	Polysaccharides	36-51	interleukin 10	Homo sapiens	263-268
23705025-5	2013	This validation study suggested LARGE, a gene encoding a protein with xylosyltransferase and glucuronyltransferase activities that forms heparin-like linear polysaccharides, as a potential modulator of antithrombin based on the significant association of one SNPs, rs762057, with anti-FXa activity, particularly after adjustment for age, sex and SERPINC1 rs2227589 genotype, all factors influencing antithrombin levels (p = 0.02).	Polysaccharides	157-172	serpin family C member 1	Homo sapiens	202-214
23705025-5	2013	This validation study suggested LARGE, a gene encoding a protein with xylosyltransferase and glucuronyltransferase activities that forms heparin-like linear polysaccharides, as a potential modulator of antithrombin based on the significant association of one SNPs, rs762057, with anti-FXa activity, particularly after adjustment for age, sex and SERPINC1 rs2227589 genotype, all factors influencing antithrombin levels (p = 0.02).	Polysaccharides	157-172	coagulation factor X	Homo sapiens	285-288
23705025-5	2013	This validation study suggested LARGE, a gene encoding a protein with xylosyltransferase and glucuronyltransferase activities that forms heparin-like linear polysaccharides, as a potential modulator of antithrombin based on the significant association of one SNPs, rs762057, with anti-FXa activity, particularly after adjustment for age, sex and SERPINC1 rs2227589 genotype, all factors influencing antithrombin levels (p = 0.02).	Polysaccharides	157-172	serpin family C member 1	Homo sapiens	346-354
23705025-5	2013	This validation study suggested LARGE, a gene encoding a protein with xylosyltransferase and glucuronyltransferase activities that forms heparin-like linear polysaccharides, as a potential modulator of antithrombin based on the significant association of one SNPs, rs762057, with anti-FXa activity, particularly after adjustment for age, sex and SERPINC1 rs2227589 genotype, all factors influencing antithrombin levels (p = 0.02).	Polysaccharides	157-172	serpin family C member 1	Homo sapiens	399-411
23548905-11	2013	They suggest that a competition between ST6GalNAc2 and C2GnT-1 for the core-1/Galbeta1,3GalNAc glycan may regulate leukocyte adhesion under fluid shear.	Polysaccharides	95-101	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	Homo sapiens	40-50
23548905-11	2013	They suggest that a competition between ST6GalNAc2 and C2GnT-1 for the core-1/Galbeta1,3GalNAc glycan may regulate leukocyte adhesion under fluid shear.	Polysaccharides	95-101	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	55-62
23548905-10	2013	Overall, the data describe the glycan microheterogeneity at the PSGL-1 N-terminus.	Polysaccharides	31-37	selectin P ligand	Homo sapiens	64-70
23557737-1	2013	PURPOSE: Progressive dynamic, relative quantitative changes were compared in glycans associated with retinal proteins of wild type (wt) and retinal degeneration 1 (rd1) mice during neonatal development and degeneration of retinae.	Polysaccharides	77-84	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	164-167
24146499-4	2013	Different doses of polysaccharides from Solanum nigrum Linne significantly inhibited the growth of mouse H22 solid tumours, improved the survival time of tumour-bearing mice, increased the proliferation of lymphocytes, elevated the levels of IL-2, and increased the concentration of calcium ions in the lymphocytes.	Polysaccharides	19-34	interleukin 2	Mus musculus	242-246
23610394-4	2013	CD169 is known as sialoadhesin (Sn), a macrophage-specific adhesion and endocytic receptor of the siglec family that recognizes sialic acid containing glycans as ligands.	Polysaccharides	151-158	sialic acid binding Ig like lectin 1	Homo sapiens	0-5
23610394-4	2013	CD169 is known as sialoadhesin (Sn), a macrophage-specific adhesion and endocytic receptor of the siglec family that recognizes sialic acid containing glycans as ligands.	Polysaccharides	151-158	sialic acid binding Ig like lectin 1	Homo sapiens	18-30
23610394-4	2013	CD169 is known as sialoadhesin (Sn), a macrophage-specific adhesion and endocytic receptor of the siglec family that recognizes sialic acid containing glycans as ligands.	Polysaccharides	151-158	sialic acid binding Ig like lectin 1	Homo sapiens	32-34
23610394-5	2013	We have recently developed liposomes decorated with glycan ligands for CD169/Sn suitable for targeted delivery to macrophages via CD169/Sn-mediated endocytosis.	Polysaccharides	52-58	sialic acid binding Ig like lectin 1	Homo sapiens	71-76
23610394-5	2013	We have recently developed liposomes decorated with glycan ligands for CD169/Sn suitable for targeted delivery to macrophages via CD169/Sn-mediated endocytosis.	Polysaccharides	52-58	sialic acid binding Ig like lectin 1	Homo sapiens	77-79
23610394-5	2013	We have recently developed liposomes decorated with glycan ligands for CD169/Sn suitable for targeted delivery to macrophages via CD169/Sn-mediated endocytosis.	Polysaccharides	52-58	sialic acid binding Ig like lectin 1	Homo sapiens	130-135
23610394-5	2013	We have recently developed liposomes decorated with glycan ligands for CD169/Sn suitable for targeted delivery to macrophages via CD169/Sn-mediated endocytosis.	Polysaccharides	52-58	sialic acid binding Ig like lectin 1	Homo sapiens	136-138
23548572-3	2013	In the present study, we demonstrated that disruption of the GLUT2 N-glycan-galectin lattice by the genetic inactivation of GnT-IVa, or by treatment of pancreatic beta cells with competitive glycan mimetics, induced the re-distribution of GLUT2 into the lipid-raft microdomain.	Polysaccharides	69-75	solute carrier family 2 member 2	Homo sapiens	61-66
23548572-3	2013	In the present study, we demonstrated that disruption of the GLUT2 N-glycan-galectin lattice by the genetic inactivation of GnT-IVa, or by treatment of pancreatic beta cells with competitive glycan mimetics, induced the re-distribution of GLUT2 into the lipid-raft microdomain.	Polysaccharides	69-75	alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A	Homo sapiens	124-131
23548572-3	2013	In the present study, we demonstrated that disruption of the GLUT2 N-glycan-galectin lattice by the genetic inactivation of GnT-IVa, or by treatment of pancreatic beta cells with competitive glycan mimetics, induced the re-distribution of GLUT2 into the lipid-raft microdomain.	Polysaccharides	69-75	solute carrier family 2 member 2	Homo sapiens	239-244
23517777-3	2013	In the present study, we aimed to evaluate the topical effects of the polysaccharide-rich extract of P. rhizoma (PEP) on atopic dermatitis.	Polysaccharides	70-84	prolyl endopeptidase	Mus musculus	113-116
23676805-5	2013	METHODS: The human commensal gut bacterium, Bacteroides ovatus, was genetically engineered to produce human KGF-2 or TGF-beta1 (BO-KGF or BO-TGF) in a regulated manner in response to the dietary polysaccharide, xylan.	Polysaccharides	195-209	fibroblast growth factor 10	Homo sapiens	108-113
23676805-5	2013	METHODS: The human commensal gut bacterium, Bacteroides ovatus, was genetically engineered to produce human KGF-2 or TGF-beta1 (BO-KGF or BO-TGF) in a regulated manner in response to the dietary polysaccharide, xylan.	Polysaccharides	195-209	transforming growth factor beta 1	Homo sapiens	117-126
23274802-3	2013	METHODS: We used a new anti-PS23 IgM and IgA ELISA assay, which evaluates a global response to all 23 polysaccharides contained in Pneumovax( ).	Polysaccharides	102-117	protein S	Homo sapiens	28-32
23376777-9	2013	The difference in glycan complexity may account for the differential impact of each branch on the biological effects of KCC4.	Polysaccharides	18-24	solute carrier family 12, member 7	Mus musculus	120-124
23359570-1	2013	Several known or putative glycosyltransferases are required for the synthesis of laminin-binding glycans on alpha-dystroglycan (alphaDG), including POMT1, POMT2, POMGnT1, LARGE, Fukutin, FKRP, ISPD and GTDC2.	Polysaccharides	97-104	protein O-mannosyltransferase 1	Homo sapiens	148-153
23359570-1	2013	Several known or putative glycosyltransferases are required for the synthesis of laminin-binding glycans on alpha-dystroglycan (alphaDG), including POMT1, POMT2, POMGnT1, LARGE, Fukutin, FKRP, ISPD and GTDC2.	Polysaccharides	97-104	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	Homo sapiens	162-169
23359570-1	2013	Several known or putative glycosyltransferases are required for the synthesis of laminin-binding glycans on alpha-dystroglycan (alphaDG), including POMT1, POMT2, POMGnT1, LARGE, Fukutin, FKRP, ISPD and GTDC2.	Polysaccharides	97-104	fukutin	Homo sapiens	178-185
23359570-1	2013	Several known or putative glycosyltransferases are required for the synthesis of laminin-binding glycans on alpha-dystroglycan (alphaDG), including POMT1, POMT2, POMGnT1, LARGE, Fukutin, FKRP, ISPD and GTDC2.	Polysaccharides	97-104	fukutin related protein	Homo sapiens	187-191
23359570-1	2013	Several known or putative glycosyltransferases are required for the synthesis of laminin-binding glycans on alpha-dystroglycan (alphaDG), including POMT1, POMT2, POMGnT1, LARGE, Fukutin, FKRP, ISPD and GTDC2.	Polysaccharides	97-104	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	193-197
23359570-1	2013	Several known or putative glycosyltransferases are required for the synthesis of laminin-binding glycans on alpha-dystroglycan (alphaDG), including POMT1, POMT2, POMGnT1, LARGE, Fukutin, FKRP, ISPD and GTDC2.	Polysaccharides	97-104	protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)	Homo sapiens	202-207
23359570-8	2013	These functional studies identify an important role of B3GNT1 in the synthesis of the uncharacterized laminin-binding glycan of alphaDG and implicate B3GNT1 as a novel causative gene for WWS.	Polysaccharides	118-124	beta-1,4-glucuronyltransferase 1	Homo sapiens	55-61
22976764-1	2013	Recent years have seen great advances in our knowledge of congenital disorders of glycosylation (CDG), a clinically and biochemically heterogeneous group of genetic diseases caused by defects in the synthesis (CDG-I) or processing (CDG-II) of glycans that form glycoconjugates.	Polysaccharides	243-250	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	232-238
23371026-0	2013	Identification of potential glycan cancer markers with sialic acid attached to sialic acid and up-regulated fucosylated galactose structures in epidermal growth factor receptor secreted from A431 cell line.	Polysaccharides	28-34	epidermal growth factor receptor	Homo sapiens	144-176
23335731-4	2013	Models for gamete recognition developed in mice had proposed that sperm bind to ZP3 glycans.	Polysaccharides	84-91	zona pellucida glycoprotein 3	Mus musculus	80-83
23371026-4	2013	Two unusual types of glycan structures were observed in sEGFR as compared with membrane-bound EGFR from the A431 cell line.	Polysaccharides	21-27	epidermal growth factor receptor	Homo sapiens	57-61
23371026-7	2013	The observation of these di-sialylated glycan structures was consistent with the observed expression of the corresponding alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 (ST8SiA2) and alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4 (ST8SiA4), by quantitative real time RT-PCR.	Polysaccharides	39-45	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	179-186
23704815-1	2013	The purpose of this study was to investigate the protective effect of polysaccharides from Boschniakia rossica against hepatotoxicity induced by carbon tetrachloride (CCl4).	Polysaccharides	70-85	chemokine (C-C motif) ligand 4	Mus musculus	167-171
23371026-7	2013	The observation of these di-sialylated glycan structures was consistent with the observed expression of the corresponding alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 (ST8SiA2) and alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4 (ST8SiA4), by quantitative real time RT-PCR.	Polysaccharides	39-45	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	249-256
23704815-6	2013	Pretreatment of mice with Boschniakia rossica polysaccharides reversed these altered parameters of mice with liver injury induced by CCl4.	Polysaccharides	46-61	chemokine (C-C motif) ligand 4	Mus musculus	133-137
23704815-7	2013	Furthermore, caspase-3 cleavage and activities, and DNA fragmentation of liver in mice treated with Boschniakia rossica polysaccharides were decreased than mice treated with CCl4 alone.	Polysaccharides	120-135	caspase 3	Mus musculus	13-22
23704815-7	2013	Furthermore, caspase-3 cleavage and activities, and DNA fragmentation of liver in mice treated with Boschniakia rossica polysaccharides were decreased than mice treated with CCl4 alone.	Polysaccharides	120-135	chemokine (C-C motif) ligand 4	Mus musculus	174-178
23392770-4	2013	Our previous studies revealed that the domain responsible for the immunosuppressive activity of glycodelin lies on its protein backbone and the glycans modulate the same.	Polysaccharides	144-151	progestagen associated endometrial protein	Homo sapiens	96-106
23695979-2	2013	It has been hypothesized that GONST1 provides precursors for the synthesis of cell wall polysaccharides, such as glucomannan.	Polysaccharides	88-103	golgi nucleotide sugar transporter 1	Arabidopsis thaliana	30-36
23456435-6	2013	The average molecular mass of CSQ2 in normal mongrel dogs was 46,306 +- 41 Da, corresponding to glycan trimming of 3-5 mannoses, depending upon the phosphate content.	Polysaccharides	96-102	calsequestrin 2	Canis lupus familiaris	30-34
23456435-7	2013	We tested whether CSQ2 glycan structures would be altered in heart tissue from mongrel dogs induced into heart failure (HF) by two very different experimental treatments, rapid ventricular pacing or repeated coronary microembolizations.	Polysaccharides	23-29	calsequestrin 2	Canis lupus familiaris	18-22
23456435-9	2013	Unique to all samples analyzed from HF dog hearts, 20-40 % of all CSQ2 contained glycans that had minimal mannose trimming (Man9,8).	Polysaccharides	81-88	calsequestrin 2	Canis lupus familiaris	66-70
23486476-7	2013	These results show that Man2C1 has dual functions: one in glycan catabolism and another in apoptotic signaling.	Polysaccharides	58-64	mannosidase alpha class 2C member 1	Homo sapiens	24-30
23650557-6	2013	GlyT2 binding to CNX was mediated by glycan and polypeptide-based interactions as revealed by pharmacological approaches and the behavior of GlyT2 N-glycan-deficient mutants.	Polysaccharides	37-43	solute carrier family 6 member 5	Homo sapiens	0-5
23650557-6	2013	GlyT2 binding to CNX was mediated by glycan and polypeptide-based interactions as revealed by pharmacological approaches and the behavior of GlyT2 N-glycan-deficient mutants.	Polysaccharides	37-43	calnexin	Homo sapiens	17-20
23416198-5	2013	In contrast, however, existing glycan array and X-ray crystallographic studies indicate that the CRDs of both SIGN-R1 and DC-SIGN bind to a restricted set of primarily oligomannose-type glycans that does not include the glycans found on sFc.	Polysaccharides	31-37	CD209b antigen	Mus musculus	110-117
23416198-5	2013	In contrast, however, existing glycan array and X-ray crystallographic studies indicate that the CRDs of both SIGN-R1 and DC-SIGN bind to a restricted set of primarily oligomannose-type glycans that does not include the glycans found on sFc.	Polysaccharides	31-37	CD209a antigen	Mus musculus	122-129
23416198-5	2013	In contrast, however, existing glycan array and X-ray crystallographic studies indicate that the CRDs of both SIGN-R1 and DC-SIGN bind to a restricted set of primarily oligomannose-type glycans that does not include the glycans found on sFc.	Polysaccharides	186-193	CD209b antigen	Mus musculus	110-117
23416198-5	2013	In contrast, however, existing glycan array and X-ray crystallographic studies indicate that the CRDs of both SIGN-R1 and DC-SIGN bind to a restricted set of primarily oligomannose-type glycans that does not include the glycans found on sFc.	Polysaccharides	186-193	CD209a antigen	Mus musculus	122-129
23416198-5	2013	In contrast, however, existing glycan array and X-ray crystallographic studies indicate that the CRDs of both SIGN-R1 and DC-SIGN bind to a restricted set of primarily oligomannose-type glycans that does not include the glycans found on sFc.	Polysaccharides	220-227	CD209b antigen	Mus musculus	110-117
23416198-5	2013	In contrast, however, existing glycan array and X-ray crystallographic studies indicate that the CRDs of both SIGN-R1 and DC-SIGN bind to a restricted set of primarily oligomannose-type glycans that does not include the glycans found on sFc.	Polysaccharides	220-227	CD209a antigen	Mus musculus	122-129
23574147-4	2013	By using affinity capture and glycan microarray techniques, the intracellular FK-506 binding protein 4 (FKBP4) was identified to bind directly to SSEA-4.	Polysaccharides	30-36	FKBP prolyl isomerase 4	Homo sapiens	78-102
23574147-4	2013	By using affinity capture and glycan microarray techniques, the intracellular FK-506 binding protein 4 (FKBP4) was identified to bind directly to SSEA-4.	Polysaccharides	30-36	FKBP prolyl isomerase 4	Homo sapiens	104-109
23445396-5	2013	The latter results established that metabolic flux, in a complementary manner to the more well-known impact of sialyltransferase expression, can critically modulate the sialylation of specific glycans while leaving others virtually unchanged.	Polysaccharides	193-200	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	111-128
23512824-5	2013	We established that Hp"s surface glycans are labeled by treatment with the metabolic substrate peracetylated N-azidoacetylglucosamine (Ac4 GlcNAz).	Polysaccharides	33-40	adenylate cyclase 4	Homo sapiens	135-138
23499089-1	2013	We have fabricated a polysaccharide nanofiber made from paramylon (beta-1,3-glucan), a storage polysaccharide stored as a micrometer-sized particle in the cell of euglenoid alga.	Polysaccharides	21-35	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	67-75
23616560-5	2013	Appetitive stimuli (sweet: glucose, sucralose; umami: monosodium glutamate; polysaccharide: Polycose) elicited GLP-1 and NPY secretion and inhibited basal glucagon secretion.	Polysaccharides	76-90	glucagon	Mus musculus	111-116
23616560-5	2013	Appetitive stimuli (sweet: glucose, sucralose; umami: monosodium glutamate; polysaccharide: Polycose) elicited GLP-1 and NPY secretion and inhibited basal glucagon secretion.	Polysaccharides	76-90	neuropeptide Y	Mus musculus	121-124
23499089-1	2013	We have fabricated a polysaccharide nanofiber made from paramylon (beta-1,3-glucan), a storage polysaccharide stored as a micrometer-sized particle in the cell of euglenoid alga.	Polysaccharides	95-109	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	67-75
23274891-0	2013	Mutations in HNF1A result in marked alterations of plasma glycan profile.	Polysaccharides	58-64	HNF1 homeobox A	Homo sapiens	13-18
23411399-3	2013	It was found that Cu(I)-catalyzed alkyne-azide cycloaddition reaction (click chemistry) between the alkyne-labeled glycan and the azide-tagged HSA led to an efficient formation of the glycoconjugates.	Polysaccharides	115-121	albumin	Homo sapiens	143-146
23274891-2	2013	We hypothesized that loss-of-function HNF1A mutations causal for maturity-onset diabetes of the young (MODY) would display altered fucosylation of N-linked glycans on plasma proteins and that glycan biomarkers could improve the efficiency of a diagnosis of HNF1A-MODY.	Polysaccharides	156-162	HNF1 homeobox A	Homo sapiens	38-43
23274891-3	2013	In a pilot comparison of 33 subjects with HNF1A-MODY and 41 subjects with type 2 diabetes, 15 of 29 glycan measurements differed between the two groups.	Polysaccharides	100-106	HNF1 homeobox A	Homo sapiens	42-47
23319563-5	2013	Using a mouse model of NCC by infection with the related parasite Mesocestoides corti, we have investigated the role of mannose receptor C type 1 (MRC1), a CLR which recognizes high-mannose-containing glycan antigens.	Polysaccharides	201-207	mannose receptor, C type 1	Mus musculus	147-151
23274891-6	2013	In conclusion, glycan profiles are altered substantially in HNF1A-MODY, and the DG9-glycan index has potential clinical value as a diagnostic biomarker of HNF1A dysfunction.	Polysaccharides	15-21	HNF1 homeobox A	Homo sapiens	60-70
23274891-6	2013	In conclusion, glycan profiles are altered substantially in HNF1A-MODY, and the DG9-glycan index has potential clinical value as a diagnostic biomarker of HNF1A dysfunction.	Polysaccharides	15-21	HNF1 homeobox A	Homo sapiens	60-65
23333909-1	2013	A water-soluble polysaccharide (MHP-1) isolated from cultured Mortierella hepiali was obtained by hot-water extraction, DEAE-cellulose 52 anion-exchange, and Sephadex G-25 gel permeation chromatography.	Polysaccharides	16-30	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	32-37
23526252-6	2013	Alkaline digestion greatly reduced the binding of rBC2LCN to podocalyxin, indicating that the major glycan ligands of rBC2LCN are presented on O-glycans.	Polysaccharides	100-106	podocalyxin like	Homo sapiens	61-72
23427003-0	2013	The expression of integrins is decreased in colon cancer cells treated with polysaccharide K. Polysaccharide K (PSK), a protein-bound polysaccharide used as a non-specific immunotherapeutic agent, is said to improve the prognosis of malignant tumors such as colon cancer, but there have been few in-depth investigations of its mechanism of action.	Polysaccharides	76-90	TAO kinase 2	Homo sapiens	112-115
23291968-6	2013	DC-SIGN recognizes specific glycans on HIV-1 and this interaction can be blocked by competitive inhibition through glycans.	Polysaccharides	28-35	CD209 molecule	Homo sapiens	0-7
23291968-6	2013	DC-SIGN recognizes specific glycans on HIV-1 and this interaction can be blocked by competitive inhibition through glycans.	Polysaccharides	115-122	CD209 molecule	Homo sapiens	0-7
23493554-2	2013	Using an array-based sequencing assay, we identified an autosomal-dominant deficiency in TNF-like weak inducer of apoptosis (TWEAK; TNFSF12) in a kindred with recurrent infection and impaired antibody responses to protein and polysaccharide vaccines.	Polysaccharides	226-240	tumor necrosis factor	Homo sapiens	89-92
23493554-2	2013	Using an array-based sequencing assay, we identified an autosomal-dominant deficiency in TNF-like weak inducer of apoptosis (TWEAK; TNFSF12) in a kindred with recurrent infection and impaired antibody responses to protein and polysaccharide vaccines.	Polysaccharides	226-240	TNF superfamily member 12	Homo sapiens	125-130
23493554-2	2013	Using an array-based sequencing assay, we identified an autosomal-dominant deficiency in TNF-like weak inducer of apoptosis (TWEAK; TNFSF12) in a kindred with recurrent infection and impaired antibody responses to protein and polysaccharide vaccines.	Polysaccharides	226-240	TNF superfamily member 12	Homo sapiens	132-139
23461434-3	2013	Finally, conjugation of the glycan to PSMA oligopeptide is described.	Polysaccharides	28-34	folate hydrolase 1	Homo sapiens	38-42
23506543-4	2013	METHODS: The association between p.C10X mutation (rs2043211) of the CARD8 gene and the levels of anti-glycans antibody response was examined in 39 CD families.	Polysaccharides	102-109	caspase recruitment domain family member 8	Homo sapiens	68-73
23457413-9	2013	The method was used to relatively quantitate the core 1 glycans from MUC7 to identify any systemic changes in this carbohydrate epitope.	Polysaccharides	56-63	mucin 7, secreted	Homo sapiens	69-73
23506543-5	2013	The family-based QTDT association test was used to test for the genetic association between CARD8 p.C10X mutation and anti-glycan antibodies in the pedigrees.	Polysaccharides	123-129	caspase recruitment domain family member 8	Homo sapiens	92-97
23362105-0	2013	Glycan sequence-dependent Nod2 activation investigated by using a chemically synthesized bacterial peptidoglycan fragment library.	Polysaccharides	0-6	nucleotide binding oligomerization domain containing 2	Homo sapiens	26-30
23395905-7	2013	Strain-specific characteristics of the 79A TSE strain changed when PrP(Sc) was devoid of one or both glycans.	Polysaccharides	101-108	prion protein	Mus musculus	67-70
23362105-5	2013	The results reveal that hNod2 recognitions is dependent on the glycan sequence, as demonstrated by comparing the activities of glycans with the same peptide moieties.	Polysaccharides	63-69	nucleotide binding oligomerization domain containing 2	Homo sapiens	24-29
23362105-5	2013	The results reveal that hNod2 recognitions is dependent on the glycan sequence, as demonstrated by comparing the activities of glycans with the same peptide moieties.	Polysaccharides	127-134	nucleotide binding oligomerization domain containing 2	Homo sapiens	24-29
23262141-0	2013	The JNk/NFkappaB pathway is required to activate murine lymphocytes induced by a sulfated polysaccharide from Ecklonia cava.	Polysaccharides	90-104	mitogen-activated protein kinase 8	Mus musculus	4-7
23262141-0	2013	The JNk/NFkappaB pathway is required to activate murine lymphocytes induced by a sulfated polysaccharide from Ecklonia cava.	Polysaccharides	90-104	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	8-16
23262141-2	2013	Therefore, we investigated whether the sulfated polysaccharide (SP) of E. cava specifically activates the protein kinases (MAPKs) and nuclear factor-kappaB (NFkappaB) to incite immune responses.	Polysaccharides	48-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-165
23238125-1	2013	Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is a cell surface receptor for sialylated glycan ligands.	Polysaccharides	104-110	sialic acid binding Ig-like lectin 15	Mus musculus	0-49
23023834-3	2013	Both families recognize different epitopes on high-mannose glycans, namely, Manalpha(1-2)Man units at the end of the D1 and D3 arms and alpha3,alpha6-mannopentaose at the central branch point of Man-8 or Man-9 for CVNH and OAAH lectins, respectively.	Polysaccharides	59-66	mannosidase alpha class 1A member 1	Homo sapiens	204-209
23368525-8	2013	Two glycan nodes provided novel evidence for altered ST6Gal-I and GnT-IV glycotransferase activities in lung cancer patients.	Polysaccharides	4-10	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	53-61
23238125-1	2013	Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is a cell surface receptor for sialylated glycan ligands.	Polysaccharides	104-110	sialic acid binding Ig-like lectin 15	Mus musculus	51-60
23135544-0	2013	LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE.	Polysaccharides	65-71	LARGE xylosyl- and glucuronyltransferase 2	Homo sapiens	0-6
23465926-5	2013	The results showed that PET surfaces coated with sulphated polysaccharides are more hydrophilic and more fibrinogen-repulsive than non-modified PET surfaces.	Polysaccharides	59-74	fibrinogen beta chain	Homo sapiens	105-115
23356641-7	2013	The present study analyzed the function of human XTP3-B, and found, by frontal affinity chromatography analysis, that its C-terminal MRH domain specifically recognized the Man9 GlcNAc2 (M9) glycan in vitro and M9 glycans on an ERAD substrate NHK, a terminally misfolded alpha1-antitrypsin variant, in vivo.	Polysaccharides	190-196	endoplasmic reticulum lectin 1	Homo sapiens	49-55
23356641-7	2013	The present study analyzed the function of human XTP3-B, and found, by frontal affinity chromatography analysis, that its C-terminal MRH domain specifically recognized the Man9 GlcNAc2 (M9) glycan in vitro and M9 glycans on an ERAD substrate NHK, a terminally misfolded alpha1-antitrypsin variant, in vivo.	Polysaccharides	190-196	serpin family A member 1	Homo sapiens	270-288
23356641-7	2013	The present study analyzed the function of human XTP3-B, and found, by frontal affinity chromatography analysis, that its C-terminal MRH domain specifically recognized the Man9 GlcNAc2 (M9) glycan in vitro and M9 glycans on an ERAD substrate NHK, a terminally misfolded alpha1-antitrypsin variant, in vivo.	Polysaccharides	213-220	endoplasmic reticulum lectin 1	Homo sapiens	49-55
23356641-11	2013	Therefore, we propose that XTP3-B recognizes M9 glycans on unfolded polypeptides, thereby acting as a negative regulator of ERAD, and also protects newly synthesized immature polypeptides from premature degradation.	Polysaccharides	48-55	endoplasmic reticulum lectin 1	Homo sapiens	27-33
23254996-8	2013	Furthermore, KSGal6ST, but not C6ST-1, is required for the generation of the Gal6S-containing glycan, 6,6"-disulfo-3"sLN (Siaalpha2 3[6S]Galbeta1 4[6S]GlcNAc) or a closely related structure in lymph node HEVs.	Polysaccharides	94-100	sarcolipin	Mus musculus	117-120
23339644-7	2013	For N-linked glycosylation, two sites (N386 and N392) in the V4 region were populated with high mannose glycans in the CHO cell-derived 1086.C gp120, while these sites had a mixture of high mannose and processed glycans in the 293T cell-derived 1086.C gp120.	Polysaccharides	104-111	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	143-148
23266598-0	2013	Polysaccharides of Dendrobium officinale inhibit TNF-alpha-induced apoptosis in A-253 cell line.	Polysaccharides	0-15	tumor necrosis factor	Homo sapiens	49-58
23242545-0	2013	Bacterial polysaccharide-mediated downregulation of TACI and B-cell apoptosis contribute to the hyporesponsiveness against bacterial polysaccharides vaccines.	Polysaccharides	10-24	TNF receptor superfamily member 13B	Homo sapiens	52-56
23242545-0	2013	Bacterial polysaccharide-mediated downregulation of TACI and B-cell apoptosis contribute to the hyporesponsiveness against bacterial polysaccharides vaccines.	Polysaccharides	133-148	TNF receptor superfamily member 13B	Homo sapiens	52-56
23238222-18	2013	Hypoxia and reoxygenation in HUVECs downregulated glycan-free AQP1 protein (-34+-24%, p=0.04) and upregulated miR-214 (+287+-52%, p&lt;0.05).	Polysaccharides	50-56	aquaporin 1	Mus musculus	62-66
23238222-19	2013	HUVECs transfected with anti-miR-214 had increased glycosylated (1.5 fold) and glycan-free (2 fold) AQP1.	Polysaccharides	79-85	microRNA 214	Mus musculus	29-36
23238222-19	2013	HUVECs transfected with anti-miR-214 had increased glycosylated (1.5 fold) and glycan-free (2 fold) AQP1.	Polysaccharides	79-85	aquaporin 1	Mus musculus	100-104
23246413-1	2013	Effects of a novel polysaccharide (PLP) from the seeds of Plantago asiatica L. on intestinal function were investigated in vitro.	Polysaccharides	19-33	proteolipid protein 1	Homo sapiens	35-38
23232447-9	2013	Moreover, heteronuclear single-quantum coherence NMR titrations showed that the presence of DB16 decreases gal-1 affinity for lactose, indicating that the peptidomimetic targets gal-1 as a noncompetitive, allosteric inhibitor of glycan binding.	Polysaccharides	229-235	galectin 1	Homo sapiens	178-183
23339644-7	2013	For N-linked glycosylation, two sites (N386 and N392) in the V4 region were populated with high mannose glycans in the CHO cell-derived 1086.C gp120, while these sites had a mixture of high mannose and processed glycans in the 293T cell-derived 1086.C gp120.	Polysaccharides	104-111	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	252-257
23339644-11	2013	Site-specific glycopeptide analysis of transmitted/founder 1086.C gp120 expressed in CHO cells revealed the presence of phosphorylated glycans, while 293T cell-produced 1086.C gp120 glycans were not phosphorylated.	Polysaccharides	135-142	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	66-71
23339644-11	2013	Site-specific glycopeptide analysis of transmitted/founder 1086.C gp120 expressed in CHO cells revealed the presence of phosphorylated glycans, while 293T cell-produced 1086.C gp120 glycans were not phosphorylated.	Polysaccharides	182-189	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	176-181
23196711-0	2013	Therapy with Astragalus polysaccharides rescues lipotoxic cardiomyopathy in MHC-PPARalpha mice.	Polysaccharides	24-39	peroxisome proliferator activated receptor alpha	Mus musculus	80-89
23399219-1	2013	The present study evaluated the anti-inflammatory activity of a polysaccharide from mate, using a clinically relevant model of sepsis induced by cecal ligation and puncture (CLP).	Polysaccharides	64-78	hyaluronan and proteoglycan link protein 1	Mus musculus	174-177
23516363-4	2013	Analysis showed that there was a wide spectrum of both Sia alpha2-3 and alpha2-6 glycans in the lung and bronchus.	Polysaccharides	81-88	immunoglobulin binding protein 1	Homo sapiens	72-80
23136055-6	2013	With subsequently introduction of rat beta-1,2-N-acetylglucosaminyltransferase II (rGnTII) and human beta-1,4-galactosyltransferase I (hGalTI), several glycoengineered strains can produce glycoproteins bearing glycans with terminal N-acetylglucosamine or galactose.	Polysaccharides	210-217	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Rattus norvegicus	38-81
23160308-1	2013	PURPOSE OF REVIEW: Siglec-8 and Siglec-F are single pass transmembrane inhibitory receptors found on the surface of human and mouse eosinophils, respectively, but very little is known about their physiologic glycan ligands.	Polysaccharides	208-214	sialic acid binding Ig like lectin 8	Homo sapiens	19-27
23269669-9	2013	Because glycosylation of proteins is altered in many diseases and in a tissue-dependent manner, the activity and/or glycan-mediated interactions of GC-C may have a crucial role to play in its functions in different cell types.	Polysaccharides	116-122	guanylate cyclase 2C	Homo sapiens	148-152
23384254-1	2013	BACKGROUND: Glycans on the human immunodeficiency virus (HIV) envelope glycoprotein (Env) play an important role in viral infection and evasion of neutralization by antibodies.	Polysaccharides	12-19	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	85-88
23190312-6	2013	An age-associated decline in the migratory response of OECs toward a gradient of VEGF significantly correlated with a reduction in the relative percentage of the trisulfated disaccharide, 2-O-sulfated-uronic acid, N, 6-O-sulfated-glucosamine (UA[2S]-GlcNS[6S]), within OEC cell surface HS polysaccharide chains.	Polysaccharides	289-303	vascular endothelial growth factor A	Homo sapiens	81-85
23220966-1	2013	Xylanase is a crucial hydrolytic enzyme that degrades plant polysaccharides in the rumen.	Polysaccharides	60-75	xylanase	Ovis aries	0-8
23230149-3	2013	We present GNAT, a platform-independent, user-extensible MATLAB-based toolbox that provides an integrated computational environment to construct, manipulate and simulate glycans and their networks.	Polysaccharides	170-177	glycine-N-acyltransferase like 1	Homo sapiens	11-15
23160308-1	2013	PURPOSE OF REVIEW: Siglec-8 and Siglec-F are single pass transmembrane inhibitory receptors found on the surface of human and mouse eosinophils, respectively, but very little is known about their physiologic glycan ligands.	Polysaccharides	208-214	sialic acid binding Ig-like lectin F	Mus musculus	32-40
23160308-3	2013	RECENT FINDINGS: Both Siglec-8 and Siglec-F recognize the same glycan structure, namely 6"-sulfated sialyl Lewis X, as determined using glycan array technologies.	Polysaccharides	63-69	sialic acid binding Ig like lectin 8	Homo sapiens	22-30
23160308-3	2013	RECENT FINDINGS: Both Siglec-8 and Siglec-F recognize the same glycan structure, namely 6"-sulfated sialyl Lewis X, as determined using glycan array technologies.	Polysaccharides	63-69	sialic acid binding Ig-like lectin F	Mus musculus	35-43
23160308-3	2013	RECENT FINDINGS: Both Siglec-8 and Siglec-F recognize the same glycan structure, namely 6"-sulfated sialyl Lewis X, as determined using glycan array technologies.	Polysaccharides	136-142	sialic acid binding Ig like lectin 8	Homo sapiens	22-30
23160308-3	2013	RECENT FINDINGS: Both Siglec-8 and Siglec-F recognize the same glycan structure, namely 6"-sulfated sialyl Lewis X, as determined using glycan array technologies.	Polysaccharides	136-142	sialic acid binding Ig-like lectin F	Mus musculus	35-43
23160308-9	2013	Knowledge of this biology may also result in novel opportunities for drug development involving glycans and glycomimetics that selectively bind to Siglec-8 and induce eosinophil death.	Polysaccharides	96-103	sialic acid binding Ig like lectin 8	Homo sapiens	147-155
22956273-7	2013	The crystal structure of N-terminal immunoglobulin-like domains of PTPsigma shows that the glycan binding site forms an elliptical surface patch of ~35 by 24 A, which interacts with sulfate groups of HSPG and CSPG.	Polysaccharides	91-97	protein tyrosine phosphatase receptor type S	Homo sapiens	67-75
23035012-1	2013	We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-recognition proteins, is expressed on a subset of macrophages and preferentially recognizes the sialyl-Tn (sTn) antigen, a tumor-associated glycan structure.	Polysaccharides	76-82	sialic acid binding Ig like lectin 15	Homo sapiens	32-41
23035012-1	2013	We previously demonstrated that Siglec-15, a member of the Siglec family of glycan-recognition proteins, is expressed on a subset of macrophages and preferentially recognizes the sialyl-Tn (sTn) antigen, a tumor-associated glycan structure.	Polysaccharides	223-229	sialic acid binding Ig like lectin 15	Homo sapiens	32-41
23261880-3	2013	Mature BSP shows extensive post-translational modifications, including attachment of glycans, sulfation, and phosphorylation, and is highly flexible with no specific 2D or 3D structure in solution or the solid state.	Polysaccharides	85-92	integrin binding sialoprotein	Homo sapiens	7-10
23221565-1	2013	The highly conserved cluster of high-mannose glycans on the HIV-1 envelope glycoprotein, gp120, has been highlighted as a target for neutralizing antibodies.	Polysaccharides	45-52	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	89-94
22956273-7	2013	The crystal structure of N-terminal immunoglobulin-like domains of PTPsigma shows that the glycan binding site forms an elliptical surface patch of ~35 by 24 A, which interacts with sulfate groups of HSPG and CSPG.	Polysaccharides	91-97	syndecan 2	Homo sapiens	200-204
23646466-9	2013	Genes related to carbohydrate metabolism included PPP1R3C, B3GNT1, and GCNT1, manifested as decreased glycogen and glycan syntheses.	Polysaccharides	115-121	protein phosphatase 1 regulatory subunit 3C	Homo sapiens	50-57
23646466-9	2013	Genes related to carbohydrate metabolism included PPP1R3C, B3GNT1, and GCNT1, manifested as decreased glycogen and glycan syntheses.	Polysaccharides	115-121	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	59-65
23646466-9	2013	Genes related to carbohydrate metabolism included PPP1R3C, B3GNT1, and GCNT1, manifested as decreased glycogen and glycan syntheses.	Polysaccharides	115-121	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	71-76
23218290-7	2013	NMR spectroscopy confirmed the polysaccharide structure to be of beta-1,3/1,6-glucan type, comprising a beta-1,3-glucan backbone and 21% degree of branching of beta-1,6-glucan side chains.	Polysaccharides	31-45	hemoglobin, beta adult major chain	Mus musculus	160-168
23713278-0	2013	[Protective effects of polysaccharides from Dendrobium huoshanense on CCl4-induced acute liver injury in mice].	Polysaccharides	23-38	chemokine (C-C motif) ligand 4	Mus musculus	70-74
23713278-1	2013	OBJECTIVE: To study the protective effects of polysaccharides from Dendrobium huoshanense (DHP) against CCl4-induced liver injury in mice.	Polysaccharides	46-61	dihydropyrimidinase	Mus musculus	91-94
23713278-1	2013	OBJECTIVE: To study the protective effects of polysaccharides from Dendrobium huoshanense (DHP) against CCl4-induced liver injury in mice.	Polysaccharides	46-61	chemokine (C-C motif) ligand 4	Mus musculus	104-108
23713278-10	2013	Furthermore, the expression of TNF-alpha was greatly decreased in groups treated with polysaccharides.	Polysaccharides	86-101	tumor necrosis factor	Mus musculus	31-40
23218323-4	2013	Simultaneously the polysaccharide SMP-W1 significantly inhibited tumor growth and increased serum superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities in rats, as well as the secretion of TNF-alpha.	Polysaccharides	19-33	catalase	Rattus norvegicus	126-134
23218323-4	2013	Simultaneously the polysaccharide SMP-W1 significantly inhibited tumor growth and increased serum superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities in rats, as well as the secretion of TNF-alpha.	Polysaccharides	19-33	catalase	Rattus norvegicus	136-139
23218323-4	2013	Simultaneously the polysaccharide SMP-W1 significantly inhibited tumor growth and increased serum superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities in rats, as well as the secretion of TNF-alpha.	Polysaccharides	19-33	tumor necrosis factor	Rattus norvegicus	225-234
23092188-2	2013	In patients with this disease, altered glycan structures in the unique hinge region of the heavy chains of IgA1 molecules lead to the exposure of antigenic determinants, which are recognized by naturally occurring antiglycan antibodies of the IgG and/or IgA1 isotype.	Polysaccharides	39-45	immunoglobulin heavy constant alpha 1	Homo sapiens	107-111
23386853-5	2013	Moreover, the presence of conserved glycan adducts on the outer face of the Calpha domain preclude the hypothesized TCR dimerization through the Calpha domain.	Polysaccharides	36-42	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	116-119
23525136-2	2013	Here, we discuss the usage of multivalent DC-SIGN-targeting glycan platforms that allow for the efficient routing of antigens to the endo-lysosomal pathway as well as to a yet uncharacterized cross-presentation mechanism inducing CD4+ and CD8+ T-cell responses.	Polysaccharides	60-66	CD4 molecule	Homo sapiens	230-233
23525136-2	2013	Here, we discuss the usage of multivalent DC-SIGN-targeting glycan platforms that allow for the efficient routing of antigens to the endo-lysosomal pathway as well as to a yet uncharacterized cross-presentation mechanism inducing CD4+ and CD8+ T-cell responses.	Polysaccharides	60-66	CD8a molecule	Homo sapiens	239-242
23372571-14	2013	We speculate that the polysaccharide fragments of LPS molecule may take part in LPS-induced IFN-gamma production by NK cells.	Polysaccharides	22-36	interferon gamma	Homo sapiens	92-101
23092188-2	2013	In patients with this disease, altered glycan structures in the unique hinge region of the heavy chains of IgA1 molecules lead to the exposure of antigenic determinants, which are recognized by naturally occurring antiglycan antibodies of the IgG and/or IgA1 isotype.	Polysaccharides	39-45	immunoglobulin heavy constant alpha 1	Homo sapiens	254-258
23030719-5	2013	We isolated clones that bind each of these targets in a glycan-dependent manner and with very strong binding constants, for example, 6.2 nM for Man9 and 44.7 nM for gp120, determined by surface plasmon resonance (SPR).	Polysaccharides	56-62	mannosidase alpha class 1A member 1	Homo sapiens	144-148
23180667-2	2013	These fragments were assembled by ligation chemistry in the first total synthesis of erythropoietin bearing four glycans.	Polysaccharides	113-120	erythropoietin	Homo sapiens	85-99
23166320-9	2013	Evaluation of the p17 antagonist activity of a panel of biotechnological heparins derived by chemical sulfation of the Escherichia coli K5 polysaccharide revealed that the highly N,O-sulfated derivative prevents the binding of p17 to both heparin and CXCR1, thus inhibiting p17-driven chemotactic migration of human monocytes with an efficiency that is higher than those of heparin and HS.	Polysaccharides	139-153	family with sequence similarity 72 member B	Homo sapiens	18-21
23166320-9	2013	Evaluation of the p17 antagonist activity of a panel of biotechnological heparins derived by chemical sulfation of the Escherichia coli K5 polysaccharide revealed that the highly N,O-sulfated derivative prevents the binding of p17 to both heparin and CXCR1, thus inhibiting p17-driven chemotactic migration of human monocytes with an efficiency that is higher than those of heparin and HS.	Polysaccharides	139-153	family with sequence similarity 72 member B	Homo sapiens	227-230
23166320-9	2013	Evaluation of the p17 antagonist activity of a panel of biotechnological heparins derived by chemical sulfation of the Escherichia coli K5 polysaccharide revealed that the highly N,O-sulfated derivative prevents the binding of p17 to both heparin and CXCR1, thus inhibiting p17-driven chemotactic migration of human monocytes with an efficiency that is higher than those of heparin and HS.	Polysaccharides	139-153	family with sequence similarity 72 member B	Homo sapiens	227-230
23030719-5	2013	We isolated clones that bind each of these targets in a glycan-dependent manner and with very strong binding constants, for example, 6.2 nM for Man9 and 44.7 nM for gp120, determined by surface plasmon resonance (SPR).	Polysaccharides	56-62	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	165-170
23151259-8	2013	N-Glycan profiles from serum and plasma samples differed largely in glycans identified in fibrinogen, suggesting that this glycoprotein represents a major factor distinguishing these body fluids.	Polysaccharides	68-75	fibrinogen beta chain	Homo sapiens	90-100
23316195-7	2012	The human PTX3 protein contains a single N-glycosylation site that is fully occupied by complex type oligosaccharides, mainly fucosylated and sialylated biantennary glycans.	Polysaccharides	165-172	pentraxin 3	Homo sapiens	10-14
23316195-10	2012	Here we review the studies on PTX3, with emphasis on the glycan-dependent mechanisms underlying pathogen recognition and crosstalk with other components of the innate immune system.	Polysaccharides	57-63	pentraxin 3	Homo sapiens	30-34
23548125-0	2013	Polysaccharide from Fuzi likely protects against starvation-induced cytotoxicity in H9c2 cells by increasing autophagy through activation of the AMPK/mTOR pathway.	Polysaccharides	0-14	mechanistic target of rapamycin kinase	Rattus norvegicus	150-154
24772670-0	2013	Marine sulfated glycans with serpin-unrelated anticoagulant properties.	Polysaccharides	16-23	serpin-ZX	Cucumis sativus	29-35
24772670-4	2013	Earlier, it was considered that the anticoagulant activities of these two marine glycans were driven mainly by a catalytic serpin-dependent mechanism likewise the mammalian heparins.	Polysaccharides	81-88	serpin-ZX	Cucumis sativus	123-129
24772670-6	2013	However, as opposed to heparins, these two previously mentioned marine glycans were proved still capable in promoting coagulation inhibition using serpin-free plasmas.	Polysaccharides	71-78	serpin-ZX	Cucumis sativus	147-153
24151602-0	2013	Role of Rheum Polysaccharide in the cytokines produced by peripheral blood monocytes in TLR4 mediated HLA-B27 associated AAU.	Polysaccharides	14-28	toll like receptor 4	Homo sapiens	88-92
23099062-2	2013	In the extracellular environment, sulfated polysaccharides anchored covalently to glycoproteins such as syndecan and also non-covalently to fibronectin fibers have been shown to bind BMP-2 through a heparin-binding domain and regulate its bioactivity.	Polysaccharides	43-58	syndecan 1	Rattus norvegicus	104-112
23099062-2	2013	In the extracellular environment, sulfated polysaccharides anchored covalently to glycoproteins such as syndecan and also non-covalently to fibronectin fibers have been shown to bind BMP-2 through a heparin-binding domain and regulate its bioactivity.	Polysaccharides	43-58	fibronectin 1	Rattus norvegicus	140-151
23099062-2	2013	In the extracellular environment, sulfated polysaccharides anchored covalently to glycoproteins such as syndecan and also non-covalently to fibronectin fibers have been shown to bind BMP-2 through a heparin-binding domain and regulate its bioactivity.	Polysaccharides	43-58	bone morphogenetic protein 2	Rattus norvegicus	183-188
23727921-7	2013	We also confirmed that the polysaccharide fraction was most effective in reducing the accumulation of tumor necrosis factor alpha (TNF-alpha)/inducible nitric oxide synthase (iNOS)-producing dendritic cells (tipDCs) in the mouse lungs.	Polysaccharides	27-41	tumor necrosis factor	Mus musculus	102-129
23727921-7	2013	We also confirmed that the polysaccharide fraction was most effective in reducing the accumulation of tumor necrosis factor alpha (TNF-alpha)/inducible nitric oxide synthase (iNOS)-producing dendritic cells (tipDCs) in the mouse lungs.	Polysaccharides	27-41	tumor necrosis factor	Mus musculus	131-140
23727921-7	2013	We also confirmed that the polysaccharide fraction was most effective in reducing the accumulation of tumor necrosis factor alpha (TNF-alpha)/inducible nitric oxide synthase (iNOS)-producing dendritic cells (tipDCs) in the mouse lungs.	Polysaccharides	27-41	nitric oxide synthase 2, inducible	Mus musculus	142-173
23727921-7	2013	We also confirmed that the polysaccharide fraction was most effective in reducing the accumulation of tumor necrosis factor alpha (TNF-alpha)/inducible nitric oxide synthase (iNOS)-producing dendritic cells (tipDCs) in the mouse lungs.	Polysaccharides	27-41	nitric oxide synthase 2, inducible	Mus musculus	175-179
24151602-0	2013	Role of Rheum Polysaccharide in the cytokines produced by peripheral blood monocytes in TLR4 mediated HLA-B27 associated AAU.	Polysaccharides	14-28	major histocompatibility complex, class I, B	Homo sapiens	102-109
24151602-1	2013	PURPOSE: To evaluate the effect of a traditional Chinese medicine, Rheum Polysaccharide (RP), on the in vitro production of tumor necrosis factor alpha (TNF- alpha ) and interleukin-10 (IL-10) by lipopolysaccharide- (LPS-)stimulated human monocytes from HLA-B27 associated acute anterior uveitis patients of convalescence stage.	Polysaccharides	73-87	tumor necrosis factor	Homo sapiens	124-151
24151602-1	2013	PURPOSE: To evaluate the effect of a traditional Chinese medicine, Rheum Polysaccharide (RP), on the in vitro production of tumor necrosis factor alpha (TNF- alpha ) and interleukin-10 (IL-10) by lipopolysaccharide- (LPS-)stimulated human monocytes from HLA-B27 associated acute anterior uveitis patients of convalescence stage.	Polysaccharides	73-87	tumor necrosis factor	Homo sapiens	153-163
24151602-1	2013	PURPOSE: To evaluate the effect of a traditional Chinese medicine, Rheum Polysaccharide (RP), on the in vitro production of tumor necrosis factor alpha (TNF- alpha ) and interleukin-10 (IL-10) by lipopolysaccharide- (LPS-)stimulated human monocytes from HLA-B27 associated acute anterior uveitis patients of convalescence stage.	Polysaccharides	73-87	interleukin 10	Homo sapiens	170-184
24151602-1	2013	PURPOSE: To evaluate the effect of a traditional Chinese medicine, Rheum Polysaccharide (RP), on the in vitro production of tumor necrosis factor alpha (TNF- alpha ) and interleukin-10 (IL-10) by lipopolysaccharide- (LPS-)stimulated human monocytes from HLA-B27 associated acute anterior uveitis patients of convalescence stage.	Polysaccharides	73-87	interleukin 10	Homo sapiens	186-191
24151602-1	2013	PURPOSE: To evaluate the effect of a traditional Chinese medicine, Rheum Polysaccharide (RP), on the in vitro production of tumor necrosis factor alpha (TNF- alpha ) and interleukin-10 (IL-10) by lipopolysaccharide- (LPS-)stimulated human monocytes from HLA-B27 associated acute anterior uveitis patients of convalescence stage.	Polysaccharides	73-87	major histocompatibility complex, class I, B	Homo sapiens	254-261
24151602-7	2013	CONCLUSION: As anti-TLR4 monoclonal antibodies, rheum Polysaccharide can also inhibit the secretion of cytokines produced by monocytes from HLA-B27 positive AAU patients of convalescence stage.	Polysaccharides	54-68	toll like receptor 4	Homo sapiens	20-24
24151602-7	2013	CONCLUSION: As anti-TLR4 monoclonal antibodies, rheum Polysaccharide can also inhibit the secretion of cytokines produced by monocytes from HLA-B27 positive AAU patients of convalescence stage.	Polysaccharides	54-68	major histocompatibility complex, class I, B	Homo sapiens	140-147
24174970-2	2013	Previous reports indicate that Amaranthus leucocarpus lectin (ALL), specific for glycans containing galactose-N-acetylgalactosamine and N-acetylgalactosamine, recognizes human naive CD27(+)CD25(+)CD4(+) T cells.	Polysaccharides	81-88	CD27 molecule	Homo sapiens	182-186
23458379-3	2013	The aim of this work was to evaluate the effect of coadministering PLc with the Vi polysaccharide antigen (Poli Vi) of S. Typhi by the i.n route.	Polysaccharides	83-97	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	67-70
24174970-2	2013	Previous reports indicate that Amaranthus leucocarpus lectin (ALL), specific for glycans containing galactose-N-acetylgalactosamine and N-acetylgalactosamine, recognizes human naive CD27(+)CD25(+)CD4(+) T cells.	Polysaccharides	81-88	interleukin 2 receptor subunit alpha	Homo sapiens	189-193
24174970-2	2013	Previous reports indicate that Amaranthus leucocarpus lectin (ALL), specific for glycans containing galactose-N-acetylgalactosamine and N-acetylgalactosamine, recognizes human naive CD27(+)CD25(+)CD4(+) T cells.	Polysaccharides	81-88	CD4 molecule	Homo sapiens	196-199
23765656-0	2013	Fluorescent lectin staining of Drosophila embryos and tissues to detect the spatial distribution of glycans during development.	Polysaccharides	100-107	lectin-37Db	Drosophila melanogaster	12-18
24367138-9	2013	Characteristic PCa PSA-IgM glycoforms pose the question of the possible role of glycosylation as a framework for immune surveillance and may be of interest in light of recent data indicating mannose-containing glycans as cancer biomarker.	Polysaccharides	210-217	kallikrein related peptidase 3	Homo sapiens	19-22
23012214-7	2013	These results suggest glycans on rLF impact the induction phase to selectively inhibit IgE responses and that differential glycosylation patterns may impact on antigen uptake, processing and/or presentation, and the balance between Th1 and Th2 responses.	Polysaccharides	22-29	RLF zinc finger	Rattus norvegicus	33-36
24302961-5	2013	The results indicated that astragalus polysaccharide inhibited the cohesion between HCMECs and polymorphonuclear leukocyte (PMN) during IRI through the downregulation of p38 MAPK signaling and the reduction of cohesive molecule expression in HCMECs.	Polysaccharides	38-52	mitogen-activated protein kinase 14	Homo sapiens	170-173
23000254-3	2013	Here, we report the effect of a polysaccharide (PLP) isolated from Pueraria lobata on phenotypic and functional maturation of DCs.	Polysaccharides	32-46	complement component 3	Mus musculus	48-51
23765656-3	2013	Lectin staining provides a useful tool to detect the spatial distribution of specific glycans in developing tissues in situ.	Polysaccharides	86-93	lectin-37Db	Drosophila melanogaster	0-6
23359164-3	2013	Given the complexity of mucin glycans, several sophisticated analytical tools such as HPLC, mass spectrometry, and lectin sandwich assays are employed for glyco-analysis of mucins.	Polysaccharides	30-37	LOC100508689	Homo sapiens	24-29
23134155-0	2013	Regulatory effects of Spirulina complex polysaccharides on growth of murine RSV-M glioma cells through Toll-like receptor 4.	Polysaccharides	40-55	toll-like receptor 4	Mus musculus	103-123
23359164-5	2013	We described in this chapter the utility of the simple electrophoresis/immunoblotting method to examine the mucin glycan epitopes, using specific antibodies and lectins.	Polysaccharides	114-120	LOC100508689	Homo sapiens	108-113
23475719-4	2013	These Fc glycans are heterogeneous and impact binding of rMAbs to Fc gamma receptors (FcgammaRs) and C1q protein.	Polysaccharides	9-16	Fc gamma receptor Ia	Homo sapiens	66-104
23457550-8	2013	Localization of the epitope to the dimerization and glycan binding sites of EBA-175 RII and site-directed mutagenesis within the predicted epitope are consistent with R215 and R217 blocking erythrocyte invasion by Plasmodium falciparum by preventing formation of the EBA-175- glycophorin A complex.	Polysaccharides	52-58	glycophorin A (MNS blood group)	Homo sapiens	276-289
23362209-2	2013	The impaired locus was identified as a pectin methylesterase inhibitor gene, PECTIN METHYLESTERASE INHIBITOR6 (PMEI6), specifically expressed in seed coat epidermal cells at the time when mucilage polysaccharides are accumulated.	Polysaccharides	197-212	Plant invertase/pectin methylesterase inhibitor superfamily protein	Arabidopsis thaliana	77-109
23555846-2	2013	IgM against glycan P63 was identified in clinically isolated syndromes (CIS) and included in gMS-Classifier2, an algorithm designed with the aim of identifying patients at risk of a second demyelinating attack.	Polysaccharides	12-18	tumor protein p63	Homo sapiens	19-22
23536887-0	2013	Suppression of core 1 Gal-transferase is associated with reduction of TF and reciprocal increase of Tn, sialyl-Tn and Core 3 glycans in human colon cancer cells.	Polysaccharides	125-132	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	15-37
23536887-1	2013	It has long been presumed, though with surprisingly little evidence, a competition between Core 1 Gal-transferase (C1GalT), Core 3 GlcNAc-transferase (C3GnT) and sialyl-transferase (ST6GalNAc-T) for elongation of O-linked mucin-type glycans initiated with GalNAcalpha-Ser/Thr.	Polysaccharides	233-240	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	91-113
23536887-3	2013	It was found that siRNA suppression of C1GalT markedly reduced the expression of Galbeta1,3GalNAcalpha- (Core 1) and in the meantime increased the expressions of sialyl-GalNAcalpha- (sialyl-Tn), GalNAcalpha- (Tn) and GlcNAcbeta1,3GalNAcalpha- (Core 3)-associated glycans in human colon cancer HT29 and SW620 cells.	Polysaccharides	263-270	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	39-45
23054013-3	2013	The polysaccharide obtained from these bacteria induces the expression of interleukin (IL)-1 beta, tumor necrosis factor, and IL-6.	Polysaccharides	4-18	interleukin 1 beta	Homo sapiens	74-97
23054013-3	2013	The polysaccharide obtained from these bacteria induces the expression of interleukin (IL)-1 beta, tumor necrosis factor, and IL-6.	Polysaccharides	4-18	interleukin 6	Homo sapiens	126-130
24149797-1	2013	The initial glycan transfer in asparagine-linked protein glycosylation is catalysed by the integral membrane enzyme oligosaccharyltransferase (OST).	Polysaccharides	12-18	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	143-146
23505583-5	2013	METHODOLOGY/PRINCIPAL FINDINGS: In a preliminary study of expressing original CTB in transgenic Nicotiana benthamiana, the protein was N-glycosylated with plant-specific glycans.	Polysaccharides	170-177	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	78-81
23516343-0	2013	Restricted N-glycan conformational space in the PDB and its implication in glycan structure modeling.	Polysaccharides	13-19	PDB1	Homo sapiens	48-51
23516343-3	2013	To address if glycan structures available in the PDB can be used as templates or fragments for glycan modeling, we present a survey of the N-glycan structures of 35 different sequences in the PDB.	Polysaccharides	14-20	PDB1	Homo sapiens	192-195
23573288-1	2013	Mannose-binding lectin (MBL) is a key soluble effector of the innate immune system that recognizes pathogen-specific surface glycans.	Polysaccharides	125-132	mannose binding lectin 2	Homo sapiens	24-27
23544079-4	2013	Other proteins of the innate immune system, namely human surfactant protein A and porcine surfactant protein D, have been reported to express sialylated glycans which facilitate inhibition of particular IAV strains, yet the specific viral determinants for recognition of these inhibitors have not been defined.	Polysaccharides	153-160	surfactant protein A1	Homo sapiens	57-77
23637599-4	2013	IgG3 antibodies are characteristic of the murine response to polysaccharide antigens.	Polysaccharides	61-75	Immunoglobulin heavy constant gamma 3	Mus musculus	0-4
23308194-0	2013	The microbial capsular polysaccharide galactoxylomannan inhibits IL-17A production in circulating T cells from rheumatoid arthritis patients.	Polysaccharides	23-37	interleukin 17A	Homo sapiens	65-71
23592978-1	2013	The HIV-1 gp120-gp41 complex, which mediates viral fusion and cellular entry, undergoes rapid evolution within its external glycan shield to enable escape from neutralizing antibody (NAb).	Polysaccharides	124-130	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	10-15
23468914-3	2013	If and how impaired TGFBR2 signaling in MSI CRC cells affects cell surface glycan pattern is largely unexplored.	Polysaccharides	75-81	transforming growth factor beta receptor 2	Homo sapiens	20-26
23326351-5	2013	The sera contained different neutralizing activities dependent on C3 and V5, C3 and V4, or V4 regions located on the glycan-rich outer domain of gp120.	Polysaccharides	117-123	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	145-150
23326351-8	2013	The activity of one serum requires specific glycans that are also important for 2G12 neutralization and this serum blocked the binding of 2G12 to gp120.	Polysaccharides	44-51	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	146-151
23658524-0	2013	Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.	Polysaccharides	142-149	CD4 molecule	Homo sapiens	62-65
23658524-6	2013	Negative-stain EM reconstructions of an engineered recombinant Env gp140 trimer (SOSIP.664) reveal that PGT122 interacts with the gp120 outer domain at a more vertical angle with respect to the top surface of the spike than the previously characterized antibody PGT128, which is also dependent on the N332 glycan.	Polysaccharides	306-312	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	130-135
23658524-8	2013	Together, these structural, functional and biophysical results suggest that the PGT121 antibodies may interfere with Env receptor engagement by an allosteric mechanism in which key structural elements, such as the V3 base, the N332 oligomannose glycan and surrounding glycans, including a putative V1/V2 complex biantennary glycan, are conformationally constrained.	Polysaccharides	268-275	endogenous retrovirus group W member 1, envelope	Homo sapiens	117-120
23592978-3	2013	In this study, we examined how the conserved gp120-gp41 association site, formed by the N- and C-terminal segments of gp120 and the disulfide-bonded region (DSR) of gp41, adapts to glycan changes that are linked to neutralization sensitivity.	Polysaccharides	181-187	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	45-50
23592978-3	2013	In this study, we examined how the conserved gp120-gp41 association site, formed by the N- and C-terminal segments of gp120 and the disulfide-bonded region (DSR) of gp41, adapts to glycan changes that are linked to neutralization sensitivity.	Polysaccharides	181-187	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	118-123
23592978-6	2013	In culture 1, gp120 association and viral replication was restored by loss of the conserved glycan at Asn136 in V1 (T138N mutation) in conjunction with the L494I substitution in C5 within the association site.	Polysaccharides	92-98	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	14-19
23592978-6	2013	In culture 1, gp120 association and viral replication was restored by loss of the conserved glycan at Asn136 in V1 (T138N mutation) in conjunction with the L494I substitution in C5 within the association site.	Polysaccharides	92-98	immunoglobulin kappa variable 1-5	Homo sapiens	112-114
23592978-8	2013	The 136 and 142 glycan mutations appeared to exert their suppressive effects by altering the dependence of gp120-gp41 interactions on the DSR residues, Leu593, Trp596 and Lys601.	Polysaccharides	16-22	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	107-112
23592978-10	2013	Thus adjacent V1 glycans allosterically modulate the distal gp120-gp41 association site.	Polysaccharides	17-24	immunoglobulin kappa variable 1-5	Homo sapiens	14-16
23136018-8	2012	MD simulations of monogalactosylated glycan isomers indicate that the galactosylated Man alpha1-3 branch preferentially folds back to the core chitobiose portion to form a compact structure.	Polysaccharides	37-43	adrenoceptor alpha 1D	Homo sapiens	89-97
23592978-10	2013	Thus adjacent V1 glycans allosterically modulate the distal gp120-gp41 association site.	Polysaccharides	17-24	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	60-65
23592978-11	2013	We propose that this represents a mechanism for functional adaptation of the gp120-gp41 association site to an evolving glycan shield in a setting of NAb selection.	Polysaccharides	120-126	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	77-82
23658524-8	2013	Together, these structural, functional and biophysical results suggest that the PGT121 antibodies may interfere with Env receptor engagement by an allosteric mechanism in which key structural elements, such as the V3 base, the N332 oligomannose glycan and surrounding glycans, including a putative V1/V2 complex biantennary glycan, are conformationally constrained.	Polysaccharides	245-251	endogenous retrovirus group W member 1, envelope	Homo sapiens	117-120
23696740-5	2013	We show that the surface accessibility of ChoP on pili is affected by phase variable changes to the structure of the pilin-linked glycan.	Polysaccharides	130-136	DNA damage inducible transcript 3	Homo sapiens	42-46
23166322-8	2012	Experiments with chimeric short arm fragments demonstrated that the LEa2-4 regions of the beta1 and gamma1 fragments are dispensable for ternary complex formation, and an engineered glycan in the beta1 LEa1 domain was also tolerated.	Polysaccharides	182-188	small nuclear ribonucleoprotein polypeptide A'	Homo sapiens	202-206
23323011-0	2012	Astragalus polysaccharides can regulate cytokine and P-glycoprotein expression in H22 tumor-bearing mice.	Polysaccharides	11-26	phosphoglycolate phosphatase	Mus musculus	53-67
23177153-6	2012	Through a 200 mum long heparin affinity column microfabricated inside a channel of 50 mum width and 20 mum height, the binding constant of each G-CSF-polysaccharide binding pair can be obtained within 1h, around one sixth of time needed by traditional capillary electrophoresis based method.	Polysaccharides	150-164	colony stimulating factor 3	Homo sapiens	144-149
23198686-2	2012	This characteristic makes the otherwise immunogenically "silent" glycan shield of gp120 a tempting target for drug and vaccine design.	Polysaccharides	65-71	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	82-87
23198686-6	2012	We were able to confirm crystallographic models that show both the binding of the linear Man(4) arm to 2G12 and also the multivalent gp120 glycan binding to 2G12.	Polysaccharides	139-145	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	133-138
22669261-2	2012	Recent studies have revealed sophisticated and complicated expression mechanisms for HNK-1 glycan.	Polysaccharides	91-97	beta-1,3-glucuronyltransferase 1	Homo sapiens	85-90
23376844-6	2012	OsrAAT has the same secondary structure and protease inhibitory activity as plasma-derived AAT (pAAT), but was highly heterogeneous with regard to glycan modifications.	Polysaccharides	147-153	serpin family A member 1	Homo sapiens	3-6
23231659-1	2012	BACKGROUND: Endo-(1,4)-beta-glucanase (cellulase) glycosyl hydrolase GH9 enzymes have been implicated in several aspects of cell wall metabolism in higher plants, including cellulose biosynthesis and degradation, modification of other wall polysaccharides that contain contiguous (1,4)-beta-glucosyl residues, and wall loosening during cell elongation.	Polysaccharides	240-255	endo-1,4-beta-glucanase	Zea mays	12-37
23151632-2	2012	In order to clarify the structural evidence for its specific binding to the alpha(1-2)mannobiose (MB) moiety of the D1 chains of high-mannose-type glycans (HMTGs) attached to HIV-1 gp120, the crystal structure of AH in complex with MB has been determined.	Polysaccharides	147-154	adrenoceptor alpha 1D	Homo sapiens	76-85
23151632-2	2012	In order to clarify the structural evidence for its specific binding to the alpha(1-2)mannobiose (MB) moiety of the D1 chains of high-mannose-type glycans (HMTGs) attached to HIV-1 gp120, the crystal structure of AH in complex with MB has been determined.	Polysaccharides	147-154	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	181-186
22453054-3	2012	Our previously published study reported a novel proteoglycan PTP1B inhibitor, named Fudan-Yueyang-Ganoderma lucidum (FYGL) from G. lucidum, with a half-maximal inhibitory concentration (IC50) value of 5 12 (sem 0 05) mug/ml, a protein:polyglycan ratio of 17:77 and 78 % glucose in polysaccharide, and dominant amino acid residues of aspartic acid, glycine, glutamic acid, alanine, serine and threonine in protein.	Polysaccharides	281-295	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	61-66
23169635-7	2012	Furthermore, PC1(lo) cells generated antigen-specific IgM responses to pneumococcal polysaccharide antigens, whereas PC1(hi) cells do not.	Polysaccharides	84-98	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	13-16
22935693-5	2012	Results of Raman and (13)C NMR spectroscopy indicated that C-6 substitution was predominant in selenized polysaccharide.	Polysaccharides	105-119	complement C6	Homo sapiens	59-62
22796642-2	2012	The crude and fractionated polysaccharides (F(1), F(2), and F(3)) consisted mostly of carbohydrates (28.9-67.0%), uronic acids (1.6-9.2%) and sulfates (5.2-13.4%) with various amounts of proteins (2.1-53.7%).	Polysaccharides	27-42	coagulation factor II	Mus musculus	50-54
22796642-5	2012	These polysaccharides (the crude and fraction F(2)) strongly stimulated macrophage cells, RAW264.7 cell line, producing considerable amounts of NO, PGE(2) and cytokines which suggested that they could be strong immunostimulators.	Polysaccharides	6-21	coagulation factor II	Mus musculus	46-50
22796642-6	2012	The main backbone of the most immunoenhancing polysaccharide (F(2)) was suggested by GC-MS and NMR to be the following: [formula, see text].	Polysaccharides	46-60	coagulation factor II	Mus musculus	62-66
23088960-6	2012	METHODS: The percentage of glycan-expressing cells among peripheral blood CD4(+)CD45RO(+) lymphocytes was determined by flow cytometry.	Polysaccharides	27-33	CD4 molecule	Homo sapiens	74-77
23010818-0	2012	Polysaccharide from Ganoderma atrum induces tumor necrosis factor-alpha secretion via phosphoinositide 3-kinase/Akt, mitogen-activated protein kinase and nuclear factor-kappaB signaling pathways in RAW264.7 cells.	Polysaccharides	0-14	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	86-111
23010818-0	2012	Polysaccharide from Ganoderma atrum induces tumor necrosis factor-alpha secretion via phosphoinositide 3-kinase/Akt, mitogen-activated protein kinase and nuclear factor-kappaB signaling pathways in RAW264.7 cells.	Polysaccharides	0-14	thymoma viral proto-oncogene 1	Mus musculus	112-115
23023583-3	2012	In this study, we predicted glycan epitopes expressed by a cancer-derived mucin, MUC1, by computational glycomics.	Polysaccharides	28-34	mucin 1, transmembrane	Mus musculus	81-85
23023583-11	2012	A library of monoclonal antibodies toward authentic MUC1 glycopeptide epitopes may be a valuable tool for studying glycan and peptide sequences in cancer, as well as reagents for diagnosis and therapy.	Polysaccharides	115-121	mucin 1, transmembrane	Mus musculus	52-56
23088960-9	2012	In contrast, the frequency of exacerbations was positively and negatively associated with CCR4(+)CCR7(+) memory Th cells expressing G152 and G159 glycans, respectively.	Polysaccharides	146-153	C-C motif chemokine receptor 4	Homo sapiens	90-94
23023295-5	2012	Moreover, it became evident that the type of linkage of Sia on N-linked glycans was dramatically changed from alpha-2-3 to alpha-2-6, and the expression of alpha-1-2 fucose and type 1 LacNAc structures became clearly apparent, while no such glycan epitopes were detected in fibroblasts.	Polysaccharides	72-78	immunoglobulin binding protein 1	Homo sapiens	123-132
23539835-4	2012	In an attempt to improve diagnosis rates, recent research efforts have focused on the discovery of non-genetic biomarkers for prioritising individuals for genetic testing, with some promising progress (identification of high-sensitivity CRP, plasma glycan profile as HNF1A-MODY).	Polysaccharides	249-255	HNF1 homeobox A	Homo sapiens	267-272
23196974-5	2012	Subsequently, polysaccharide-recognizing CD4(+) T cells are expanded in vitro by stimulating splenic CD4(+) T cells with GBSIII-TT.	Polysaccharides	14-28	CD4 antigen	Mus musculus	41-44
23196974-5	2012	Subsequently, polysaccharide-recognizing CD4(+) T cells are expanded in vitro by stimulating splenic CD4(+) T cells with GBSIII-TT.	Polysaccharides	14-28	CD4 antigen	Mus musculus	101-104
23122659-3	2012	GNE myopathy, associated with impaired glycan sialylation, has no approved therapy.	Polysaccharides	39-45	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	0-3
22992031-0	2012	Effects of shark cartilage polysaccharides on the secretion of IL-6 and IL-12 in rheumatoid arthritis.	Polysaccharides	27-42	interleukin 6	Rattus norvegicus	63-67
22992031-0	2012	Effects of shark cartilage polysaccharides on the secretion of IL-6 and IL-12 in rheumatoid arthritis.	Polysaccharides	27-42	interleukin 12B	Rattus norvegicus	72-77
22607556-2	2012	We wanted to evaluate whether two mannose-specific CBAs, recognizing multiple and often distinct glycan structures on the HIV envelope gp120, can interact synergistically against HIV-1, HIV-2, and HIV-1 strains that were selected for resistance against particular CBAs [i.e., 2G12 mAb and microvirin (MVN)].	Polysaccharides	97-103	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	135-140
22944432-5	2012	Moreover, treatment with two acidic polysaccharides caused an enhancement of superoxide dismutase (SOD) and catalase (CAT) activities in tumor-bearing mice and a reduction in thiobarbituric acid reactive substances (TBARS) level.	Polysaccharides	36-51	catalase	Mus musculus	118-121
23038983-2	2012	Mutations in the human ALG3 gene cause changed levels and altered glycan structures on mature glycoproteins and are the cause of a severe congenital disorder of glycosylation (CDG-Id).	Polysaccharides	66-72	ALG3 alpha-1,3- mannosyltransferase	Homo sapiens	23-27
22714097-10	2012	By the Western blot analysis after two-dimensional electrophoresis (2-DE) of isoforms of EPO, we confirmed that 30Kc19 enhanced the sialylation of EPO glycans.	Polysaccharides	151-158	erythropoietin	Cricetulus griseus	89-92
22714097-10	2012	By the Western blot analysis after two-dimensional electrophoresis (2-DE) of isoforms of EPO, we confirmed that 30Kc19 enhanced the sialylation of EPO glycans.	Polysaccharides	151-158	erythropoietin	Cricetulus griseus	147-150
22728640-1	2012	In this paper, the composition and biological activities of polysaccharides from Inula britannica flower IBP obtained by water extraction were investigated.	Polysaccharides	60-75	trafficking protein particle complex 9	Mus musculus	105-108
23046137-4	2012	Binding, kinetic, and thermodynamic studies of IL-7 and IL-7Ralpha show that glycosylation and electrostatics can be important to interactions between interleukins and their receptor, even where the glycans and charged residues are distant from the interface.	Polysaccharides	199-206	interleukin 7	Homo sapiens	47-51
23046137-4	2012	Binding, kinetic, and thermodynamic studies of IL-7 and IL-7Ralpha show that glycosylation and electrostatics can be important to interactions between interleukins and their receptor, even where the glycans and charged residues are distant from the interface.	Polysaccharides	199-206	interleukin 7 receptor	Homo sapiens	56-66
23187000-0	2012	Expression level and glycan dynamics determine the net effects of TIMP-1 on cancer progression.	Polysaccharides	21-27	TIMP metallopeptidase inhibitor 1	Homo sapiens	66-72
23187000-4	2012	The structural analysis of the catalytic domain of human stromelysin-1 (MMP-3) and human TIMP-1 suggests new possibilities of the role of TIMP-1 glycan moieties as a tuner for the proteolytic activities by MMPs.	Polysaccharides	145-151	matrix metallopeptidase 3	Homo sapiens	57-70
23187000-4	2012	The structural analysis of the catalytic domain of human stromelysin-1 (MMP-3) and human TIMP-1 suggests new possibilities of the role of TIMP-1 glycan moieties as a tuner for the proteolytic activities by MMPs.	Polysaccharides	145-151	matrix metallopeptidase 3	Homo sapiens	72-77
23187000-4	2012	The structural analysis of the catalytic domain of human stromelysin-1 (MMP-3) and human TIMP-1 suggests new possibilities of the role of TIMP-1 glycan moieties as a tuner for the proteolytic activities by MMPs.	Polysaccharides	145-151	TIMP metallopeptidase inhibitor 1	Homo sapiens	89-95
23187000-4	2012	The structural analysis of the catalytic domain of human stromelysin-1 (MMP-3) and human TIMP-1 suggests new possibilities of the role of TIMP-1 glycan moieties as a tuner for the proteolytic activities by MMPs.	Polysaccharides	145-151	TIMP metallopeptidase inhibitor 1	Homo sapiens	138-144
23187000-4	2012	The structural analysis of the catalytic domain of human stromelysin-1 (MMP-3) and human TIMP-1 suggests new possibilities of the role of TIMP-1 glycan moieties as a tuner for the proteolytic activities by MMPs.	Polysaccharides	145-151	matrix metallopeptidase 3	Homo sapiens	206-210
22878139-5	2012	These polysaccharides strongly induced the production of various cytokines from both murine splenocytes and bone marrow-derived dendritic cells in the presence of exogenous granulocyte-macrophage colony-stimulating factor.	Polysaccharides	6-21	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	173-221
22878139-6	2012	Polysaccharide-induced cytokine production was significantly reduced in bone marrow-derived dendritic cells derived from dectin-1-deficient mice.	Polysaccharides	0-14	C-type lectin domain family 7, member a	Mus musculus	121-129
22728640-3	2012	The results showed that IBP consisted of two kinds of polysaccharides with the molecular weight of 3500 Da, 700 Da.	Polysaccharides	54-69	trafficking protein particle complex 9	Mus musculus	24-27
22728640-5	2012	The IR spectrum of IBP revealed the typical characteristics of polysaccharides and protein.	Polysaccharides	63-78	trafficking protein particle complex 9	Mus musculus	19-22
22978303-1	2012	BACKGROUND: Type 1 polysaccharide storage myopathy (PSSM1), an equine glycogen storage disorder caused by a gain of function mutation (R309H) in the gene encoding glycogen synthase (GYS1), is associated with the accumulation of amylase-resistant alpha-crystalline polysaccharide inclusions within skeletal muscle.	Polysaccharides	19-33	glycogen synthase 1	Equus caballus	182-186
22795310-5	2012	But integrin-alpha5 (CD49e) and carcinoembryonic antigen-related cell adhesion molecule 5 (CD66e) having these glycans were specifically found in U937 (human T-lymphoma) and MKN45 (human gastric cancer) cells, respectively.	Polysaccharides	111-118	integrin subunit alpha 5	Homo sapiens	4-19
22795310-5	2012	But integrin-alpha5 (CD49e) and carcinoembryonic antigen-related cell adhesion molecule 5 (CD66e) having these glycans were specifically found in U937 (human T-lymphoma) and MKN45 (human gastric cancer) cells, respectively.	Polysaccharides	111-118	integrin subunit alpha 5	Homo sapiens	21-26
22795310-5	2012	But integrin-alpha5 (CD49e) and carcinoembryonic antigen-related cell adhesion molecule 5 (CD66e) having these glycans were specifically found in U937 (human T-lymphoma) and MKN45 (human gastric cancer) cells, respectively.	Polysaccharides	111-118	CEA cell adhesion molecule 5	Homo sapiens	32-89
22795310-5	2012	But integrin-alpha5 (CD49e) and carcinoembryonic antigen-related cell adhesion molecule 5 (CD66e) having these glycans were specifically found in U937 (human T-lymphoma) and MKN45 (human gastric cancer) cells, respectively.	Polysaccharides	111-118	CEA cell adhesion molecule 5	Homo sapiens	91-96
22956764-8	2012	In pmm2 morphants, the free glycan by-products of LLO cleavage increased nearly twofold.	Polysaccharides	28-34	phosphomannomutase 2	Danio rerio	3-7
23027923-6	2012	Targeted disruption of Gal-1-N-glycan interactions eliminated hypoxia-driven angiogenesis and suppressed tumorigenesis in vivo.	Polysaccharides	31-37	galectin 1	Homo sapiens	23-28
23086475-4	2012	Here we show, in two HIV-1-infected individuals who developed BCN antibodies targeting the glycan at Asn332 on the gp120 envelope, that this glycan was absent on the initial infecting virus.	Polysaccharides	91-97	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	115-120
23086475-4	2012	Here we show, in two HIV-1-infected individuals who developed BCN antibodies targeting the glycan at Asn332 on the gp120 envelope, that this glycan was absent on the initial infecting virus.	Polysaccharides	141-147	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	115-120
23001782-2	2012	Several molecular mechanisms of action of hSHBG, including the function of its attached glycans remain unknown.	Polysaccharides	88-95	sex hormone binding globulin	Homo sapiens	42-47
23001782-10	2012	Interestingly, the size and charge heterogeneity were shown to originate predominantly from differential Asn(351)  glycan occupancies and N-glycan sialylation that may modulate the hSHBG activity.	Polysaccharides	115-121	sex hormone binding globulin	Homo sapiens	181-186
23001782-11	2012	To date, this work represents the most detailed structural map of the heterogeneous hSHBG glycosylation, which is a prerequisite for investigating the functional aspects of the hSHBG glycans.	Polysaccharides	183-190	sex hormone binding globulin	Homo sapiens	84-89
23001782-11	2012	To date, this work represents the most detailed structural map of the heterogeneous hSHBG glycosylation, which is a prerequisite for investigating the functional aspects of the hSHBG glycans.	Polysaccharides	183-190	sex hormone binding globulin	Homo sapiens	177-182
22796095-5	2012	Molecular modeling studies using MODELLER show that the binding residues of CBM3a and the active site residues of the catalytic domain are more favorably oriented for binding and hydrolysis of the polysaccharide in the case of CelA-BC as compared to those in CelA-CB, which corresponds with higher activity of the former.	Polysaccharides	197-211	kil protein	Escherichia coli	227-231
22796095-5	2012	Molecular modeling studies using MODELLER show that the binding residues of CBM3a and the active site residues of the catalytic domain are more favorably oriented for binding and hydrolysis of the polysaccharide in the case of CelA-BC as compared to those in CelA-CB, which corresponds with higher activity of the former.	Polysaccharides	197-211	kil protein	Escherichia coli	259-263
22940126-4	2012	Herein polyamidoamine (PAMAM) dendrimers was functionalized by a polysaccharide hyaluronic acid (HA) to effectively deliver DOX as well as MVP targeted small-interfering RNA (MVP-siRNA) to down regulate MVP expression and improve DOX chemotherapy in MCF-7/ADR cells.	Polysaccharides	65-79	major vault protein	Homo sapiens	139-142
22998638-7	2012	TLP isoforms varied in susceptibility to haze formation and in interactions with polysaccharides and phenolics.	Polysaccharides	81-96	TATA-box binding protein like 1	Homo sapiens	0-3
22970832-4	2012	In a proof of principle and motivated by the importance of glycan-modified materials, many alkynyl-terminated mannose units were grated onto graphene/TTF-N(3).	Polysaccharides	59-65	ras homolog family member H	Homo sapiens	150-153
22692045-4	2012	Here, we characterize the substrate specificity of human Sulf-2 using site-specifically radiolabeled synthetic polysaccharides.	Polysaccharides	111-126	sulfatase 2	Homo sapiens	57-63
22849435-2	2012	There is ample evidence that vWF glycan moieties are crucial determinants of its expression and function.	Polysaccharides	33-39	von Willebrand factor	Homo sapiens	29-32
22967301-0	2012	Molecular dynamics simulation of Autotaxin: roles of the nuclease-like domain and the glycan modification.	Polysaccharides	86-92	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	33-42
22858483-6	2012	Deposited by this modified sludge, a fouling layer with smaller thickness, larger porosity and less proteins and polysaccharides accumulation was formed in the S-MBR, demonstrating that the combined system was able to alleviate membrane fouling.	Polysaccharides	113-128	translocator protein	Homo sapiens	162-165
22840049-1	2012	One polysaccharide PTP was isolated and purified from the roots of Polygala tenuifolia.	Polysaccharides	4-18	protein tyrosine phosphatase receptor type U	Homo sapiens	19-22
22641772-0	2012	Restricted processing of glycans by endomannosidase in mammalian cells.	Polysaccharides	25-32	mannosidase endo-alpha	Homo sapiens	36-51
22950532-7	2012	Furthermore, we demonstrate the compatibility of this novel staining procedure with glycan analysis using porcine gastric mucin as a model mucin.	Polysaccharides	84-90	LOC100508689	Homo sapiens	139-144
22939333-4	2012	Nevertheless, the intracellular polysaccharides inhibited other human hepatocarcinoma cells such as BEL-7402 and Huh-7 but luckily stimulated human normal liver cell L02 only in a positive dose- and time-dependent manner; so did the sulfated extracellular polysaccharides when it inhibited HepG2 and L02 cells.	Polysaccharides	32-47	MIR7-3 host gene	Homo sapiens	113-118
22921741-3	2012	Whereas polysaccharide-protein conjugate vaccines against meningococcal serogroups A, C, W and Y (MenA, MenC, MenW, MenY) are on the market, a vaccine able to protect against MenX has never been achieved.	Polysaccharides	8-22	ENAH actin regulator	Homo sapiens	98-102
22921741-8	2012	The different stereochemistry of the N-acetyl group at position C(2) of mannosamine (MenA CPS) and glucosamine (MenX CPS) respectively might play a fundamental role in this susceptibility to polysaccharide chain degradation.	Polysaccharides	191-205	ENAH actin regulator	Homo sapiens	85-89
22714643-10	2012	Moreover, the SSL3(R308A) mutant lacking glycan-binding properties shows lower TLR2 inhibition.	Polysaccharides	41-47	toll-like receptor 2 type-1	Gallus gallus	79-83
22914050-7	2012	Lastly, using an integrative bioinformatic approach, we show that p40(phox) deficiency leads to upregulation of chemokine receptor 1 and downregulation of enzymes involved in glycan modifications, including fucosyltransferases and sialyltransferases, during inflammation.	Polysaccharides	175-181	interleukin 9	Mus musculus	66-69
22714643-9	2012	The SSL3-TLR2 interaction is partially glycan dependent as binding of SSL3 to TLR2 is affected upon removal of sialic acid residues.	Polysaccharides	39-45	toll-like receptor 2 type-1	Gallus gallus	9-13
22492991-8	2012	These included the first X-linked CDG-I due to a de novo mutation in ALG13, and compound heterozygous mutations in DPAGT1, together the first two steps in dolichol-PP-glycan assembly, and mutations in PGM1 in two cases, involved in nucleotide sugar biosynthesis.	Polysaccharides	167-173	dolichyl-phosphate N-acetylglucosaminephosphotransferase 1	Homo sapiens	115-121
22985399-0	2012	Polysaccharide isolated from Angelica sinensis inhibits hepcidin expression in rats with iron deficiency anemia.	Polysaccharides	0-14	hepcidin antimicrobial peptide	Rattus norvegicus	56-64
22877213-1	2012	Assessing interactions of a glycan-binding protein (GBP) or lectin with glycans on a microarray generates large datasets, making it difficult to identify a glycan structural motif or determinant associated with the highest apparent binding strength of the GBP.	Polysaccharides	72-79	galectin 1	Homo sapiens	28-50
22714643-9	2012	The SSL3-TLR2 interaction is partially glycan dependent as binding of SSL3 to TLR2 is affected upon removal of sialic acid residues.	Polysaccharides	39-45	toll-like receptor 2 type-1	Gallus gallus	78-82
22877213-1	2012	Assessing interactions of a glycan-binding protein (GBP) or lectin with glycans on a microarray generates large datasets, making it difficult to identify a glycan structural motif or determinant associated with the highest apparent binding strength of the GBP.	Polysaccharides	72-79	galectin 1	Homo sapiens	52-55
22877213-1	2012	Assessing interactions of a glycan-binding protein (GBP) or lectin with glycans on a microarray generates large datasets, making it difficult to identify a glycan structural motif or determinant associated with the highest apparent binding strength of the GBP.	Polysaccharides	28-34	galectin 1	Homo sapiens	52-55
22877213-1	2012	Assessing interactions of a glycan-binding protein (GBP) or lectin with glycans on a microarray generates large datasets, making it difficult to identify a glycan structural motif or determinant associated with the highest apparent binding strength of the GBP.	Polysaccharides	28-34	galectin 1	Homo sapiens	256-259
22877213-2	2012	We have developed a computational method, termed GlycanMotifMiner, that uses the relative binding of a GBP with glycans within a glycan microarray to automatically reveal the glycan structural motifs recognized by a GBP.	Polysaccharides	112-119	galectin 1	Homo sapiens	103-106
22877213-2	2012	We have developed a computational method, termed GlycanMotifMiner, that uses the relative binding of a GBP with glycans within a glycan microarray to automatically reveal the glycan structural motifs recognized by a GBP.	Polysaccharides	112-119	galectin 1	Homo sapiens	216-219
22877213-2	2012	We have developed a computational method, termed GlycanMotifMiner, that uses the relative binding of a GBP with glycans within a glycan microarray to automatically reveal the glycan structural motifs recognized by a GBP.	Polysaccharides	112-118	galectin 1	Homo sapiens	103-106
22877213-2	2012	We have developed a computational method, termed GlycanMotifMiner, that uses the relative binding of a GBP with glycans within a glycan microarray to automatically reveal the glycan structural motifs recognized by a GBP.	Polysaccharides	112-118	galectin 1	Homo sapiens	216-219
22877213-2	2012	We have developed a computational method, termed GlycanMotifMiner, that uses the relative binding of a GBP with glycans within a glycan microarray to automatically reveal the glycan structural motifs recognized by a GBP.	Polysaccharides	129-135	galectin 1	Homo sapiens	103-106
22877213-2	2012	We have developed a computational method, termed GlycanMotifMiner, that uses the relative binding of a GBP with glycans within a glycan microarray to automatically reveal the glycan structural motifs recognized by a GBP.	Polysaccharides	129-135	galectin 1	Homo sapiens	216-219
22877213-9	2012	A more complex analysis was also carried out using glycan microarray data obtained for a recombinant form of human galectin-8.	Polysaccharides	51-57	galectin 8	Homo sapiens	115-125
22967315-0	2012	In silico-aided design of a glycan ligand of sialoadhesin for in vivo targeting of macrophages.	Polysaccharides	28-34	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	45-57
22921759-1	2012	These molecules, like surfactant protein D (SP-D) can recognize glycans on pathogens and neutralize these.	Polysaccharides	64-71	surfactant protein D	Homo sapiens	44-48
22909447-1	2012	Here we demonstrate a polysaccharide hydrogel reinforced with finely dispersed single-walled carbon nanotubes (SWNTs) using biocompatible dispersants O-carboxymethylchitosan (OC) and chondroitin sulfate A (CS-A) as a structural support.	Polysaccharides	22-36	chorionic somatomammotropin hormone 1	Homo sapiens	206-210
22793881-2	2012	This study investigated the in vivo and in vitro prebiotic effects of an aqueous extract of A. formosanus (SAEAF) and of an indigestible polysaccharide (AFP) isolated from SAEAF.	Polysaccharides	137-151	alpha fetoprotein	Mus musculus	153-156
22949645-7	2012	The possible assembly of the huge in vivo enzyme-substrate complex consisting of glycan-bound mannan-binding lectin, MASP-2, and C4 is discussed.	Polysaccharides	81-87	MBL associated serine protease 2	Homo sapiens	117-123
22885037-4	2012	Integrated with two dimensional gel electrophoresis, high purity clusterin in microgram quantities suitable for glycan characterization was isolated.	Polysaccharides	112-118	clusterin	Homo sapiens	65-74
22793881-7	2012	Thus, AFP, a polysaccharide from A. formosanus, was demonstrated to be a prebiotic that has a positive health effect on gut microbiota.	Polysaccharides	13-27	alpha fetoprotein	Mus musculus	6-9
22079206-1	2012	The common food additive kappa-carrageenan (kappa-CGN) is a sulfated polysaccharide that resembles chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Polysaccharides	69-83	cingulin	Homo sapiens	50-53
22751611-7	2012	The data indicated that the glycan differences of serum PON1 might serve as potential glycan biomarkers for distinguishing early HCC from LC patients.	Polysaccharides	28-34	paraoxonase 1	Homo sapiens	56-60
22751611-7	2012	The data indicated that the glycan differences of serum PON1 might serve as potential glycan biomarkers for distinguishing early HCC from LC patients.	Polysaccharides	86-92	paraoxonase 1	Homo sapiens	56-60
22817996-9	2012	It is anticipated that the knowledge gained from the present study will facilitate future studies of the role of the glycans of human OVGP1 in fertilization and early embryo development.	Polysaccharides	117-124	oviductal glycoprotein 1	Homo sapiens	134-139
22943418-2	2012	EndoS hydrolysis of the IgG glycan has profound effects on IgG effector functions, such as complement activation and Fc receptor binding, suggesting that the enzyme could be used as an immunomodulatory therapeutic agent against IgG-mediated diseases.	Polysaccharides	28-34	Fc receptor	Mus musculus	117-128
22547138-0	2012	Comparative study of the glycan specificities of cell-bound human tandem-repeat-type galectin-4, -8 and -9.	Polysaccharides	25-31	galectin 4	Homo sapiens	85-106
22837487-3	2012	We demonstrate that Abs generated against conserved bacterial polysaccharides are reactive with and dampen the immune response against chitin and Aspergillus fumigatus.	Polysaccharides	62-77	DEAD box helicase 41	Mus musculus	20-23
22837487-4	2012	A reduction in Ag uptake, cell influx, cell activation, and cytokine production occurred in the presence of anti-polysaccharide Abs, resulting in a striking decrease in the severity of allergic airway disease in mice.	Polysaccharides	113-127	DEAD box helicase 41	Mus musculus	128-131
22745059-11	2012	EndoBI-1 is constitutively expressed in B. infantis, and incubation of the bacterium with human or bovine lactoferrin led to the induction of genes associated to import and consumption of human milk oligosaccharides, suggesting linked regulatory mechanisms among these glycans.	Polysaccharides	269-276	lactotransferrin	Bos taurus	106-117
22776833-0	2012	MDG-1, a polysaccharide from Ophiopogon japonicus exerts hypoglycemic effects through the PI3K/Akt pathway in a diabetic KKAy mouse model.	Polysaccharides	9-23	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	0-5
22809717-1	2012	Phosphoglucomutase (PGM) plays an important role in polysaccharide capsule formation and virulence in a number of bacterial pathogens.	Polysaccharides	52-66	phosphoglucomutase-1	Oryctolagus cuniculus	20-23
23086645-8	2012	The characteristic ladder of apoptosis in DNA electrophoresis was detected in MCF-7 cells treated with 10.0 mumol/L polysaccharide of snakegourd root at d 2.	Polysaccharides	116-130	immunoglobulin heavy diversity 2-15	Homo sapiens	153-156
23086645-12	2012	CONCLUSION: The polysaccharide of snakegourd root can induce the apoptosis of MCF-7 cells,which is associated with the activation of intracellular Caspase-3 and Caspase-8.	Polysaccharides	16-30	caspase 3	Homo sapiens	147-156
23086645-12	2012	CONCLUSION: The polysaccharide of snakegourd root can induce the apoptosis of MCF-7 cells,which is associated with the activation of intracellular Caspase-3 and Caspase-8.	Polysaccharides	16-30	caspase 8	Homo sapiens	161-170
22683540-0	2012	Quantitative glycan profiling of normal human plasma derived immunoglobulin and its fragments Fab and Fc.	Polysaccharides	13-19	FA complementation group B	Homo sapiens	94-97
22683540-2	2012	Quantitative high-resolution glycan profiles of IgG and its Fc-Fab fragments are presented here.	Polysaccharides	29-35	FA complementation group B	Homo sapiens	63-66
22683540-6	2012	Both isolated Fab fragments and the previously deglycosylated IVIG (native conditions) yielded the same glycan profile.	Polysaccharides	104-110	FA complementation group B	Homo sapiens	14-17
22683540-13	2012	The distribution of bisecting N-acetylglucosamine and fucose was found to be very different in various glycans (N, S1 and S2) found in Fab and Fc.	Polysaccharides	103-110	FA complementation group B	Homo sapiens	135-138
22683540-14	2012	Total IgG glycan profile (Fab plus Fc) contained N, 78.5%; S1, 17% and S2, 4.5%.	Polysaccharides	10-16	FA complementation group B	Homo sapiens	26-29
22683540-17	2012	A fast HPLC profiling method was developed for the separation and quantitation of IgG glycans (neutral (G0, G1, and G2), mono- and di-sialylated) using simple procedures.	Polysaccharides	86-93	proline rich protein BstNI subfamily 3	Homo sapiens	103-118
22715095-0	2012	Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V.	Polysaccharides	129-135	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B	Homo sapiens	48-82
22801424-0	2012	Human natural killer-1 sulfotransferase (HNK-1ST)-induced sulfate transfer regulates laminin-binding glycans on alpha-dystroglycan.	Polysaccharides	101-108	carbohydrate sulfotransferase 10	Homo sapiens	41-48
22801424-5	2012	Knockdown of HNK-1ST restored the glycosylation of alpha-DG and the migration of RA-treated S91 cells, indicating that HNK-1ST functions through glycans on alpha-DG.	Polysaccharides	145-152	carbohydrate sulfotransferase 10	Mus musculus	13-20
22801424-5	2012	Knockdown of HNK-1ST restored the glycosylation of alpha-DG and the migration of RA-treated S91 cells, indicating that HNK-1ST functions through glycans on alpha-DG.	Polysaccharides	145-152	carbohydrate sulfotransferase 10	Mus musculus	119-126
22801424-9	2012	These findings suggest a novel role for HNK-1ST as a tumor suppressor controlling the functional glycans on alpha-DG and the importance of sulfate transfer in the glycosylation of alpha-DG.	Polysaccharides	97-104	carbohydrate sulfotransferase 10	Homo sapiens	40-47
22715095-0	2012	Developmental expression of the neuron-specific N-acetylglucosaminyltransferase Vb (GnT-Vb/IX) and identification of its in vivo glycan products in comparison with those of its paralog, GnT-V.	Polysaccharides	129-135	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B	Homo sapiens	84-93
22658221-7	2012	The lack of evidence for hydrolysis of these potential substrates in vivo suggests either that the enzyme and potential substrates are not accessible to each other for some reason, or that the main activity of endo-beta-mannanase is not hydrolysis but transglycosylation, a reaction in which polysaccharide substrates and end-products are indistinguishable.	Polysaccharides	292-306	LOW QUALITY PROTEIN: mannan endo-1,4-beta-mannosidase 3	Solanum lycopersicum	210-229
22883599-7	2012	CONCLUSIONS: Our results indicate that the extracellular polysaccharides produced by G. formosanum stimulate macrophages via the engagement of multiple pattern-recognition receptors including Dectin-1, CR3 and TLR4, resulting in the activation of Syk, JNK, p38, ERK, and NK-kappaB and the production of TNF-alpha.	Polysaccharides	57-72	toll-like receptor 4	Mus musculus	210-214
22944683-0	2012	Anticancer peptide NK-2 targets cell surface sulphated glycans rather than sialic acids.	Polysaccharides	55-62	NK2 homeobox 1	Homo sapiens	19-23
22685299-2	2012	The innate host defense component surfactant protein D (SP-D) interacts with glycans on the hemagglutinin of IAV and contributes to protection against IAV infection in mammals.	Polysaccharides	77-84	surfactant protein D	Sus scrofa	34-54
22685299-2	2012	The innate host defense component surfactant protein D (SP-D) interacts with glycans on the hemagglutinin of IAV and contributes to protection against IAV infection in mammals.	Polysaccharides	77-84	surfactant protein D	Homo sapiens	56-60
22722744-7	2012	Interestingly, the quantitative analysis showed that non-sialylated, fucosylated complex-type glycans dominated the N-glycans of CD44s.	Polysaccharides	94-101	CD44 molecule (Indian blood group)	Homo sapiens	129-133
22860915-5	2012	N-Glycosylation and particularly the content of nonfucosylated glycans are crucial for affinity of mAb to FcgammaRIIIA, which plays the key role in the clearance of sensitized cells.	Polysaccharides	63-70	Fc gamma receptor IIIa	Homo sapiens	106-118
22944683-4	2012	We focus on the interaction of alpha-helical peptides NK-2, cathelicidin LL32, and melittin with PC-3 prostate cancer cells, and we provide strong evidence that, amongst the anionic glycans covering the cell surface, sulphated carbohydrates rather than sialic acids are the preferred interaction sites of the peptides.	Polysaccharides	182-189	NK2 homeobox 1	Homo sapiens	54-58
22944683-6	2012	Amongst 465 mammalian glycan structures on the chip, more than 20 different sulphated glycans were detected as the preferred binding partners of the peptide NK-2.	Polysaccharides	22-28	NK2 homeobox 1	Homo sapiens	157-161
22944683-6	2012	Amongst 465 mammalian glycan structures on the chip, more than 20 different sulphated glycans were detected as the preferred binding partners of the peptide NK-2.	Polysaccharides	86-93	NK2 homeobox 1	Homo sapiens	157-161
22739242-1	2012	New fluorescent polysaccharides were synthesized by grafting the nucleobase adenine on to the backbones of agarose and kappa-carrageenan, which were characterized by FT-IR, (13)C NMR, TGA, XRD, UV, and fluorescence properties.	Polysaccharides	16-31	T-box transcription factor 1	Homo sapiens	184-187
22331282-1	2012	Heparanase is the sole mammalian endoglycosidase that cleaves heparan sulfate, the key polysaccharide of the extracellular matrix and basement membranes.	Polysaccharides	87-101	heparanase	Homo sapiens	0-10
22585296-6	2012	Sialic acid-dependent binding of siglec-7 tetramers was confirmed by glycan array analysis and loss of siglec tetramer binding after neuraminidase treatment of lymphocytes.	Polysaccharides	69-75	sialic acid binding Ig like lectin 7	Homo sapiens	33-41
22622993-2	2012	Beta1,4-galactose terminal glycans are potent inducers of IFN-gamma.	Polysaccharides	27-34	interferon gamma	Mus musculus	58-67
24750915-3	2012	The results demonstrated that C. kwangsiensis polysaccharides can significantly inhibit the proliferation of CNE-2 cells, which was possibly through the induction of apoptosis mediated by attenuating Bcl-2 expression and promoting p53 expression.	Polysaccharides	46-61	BCL2 apoptosis regulator	Homo sapiens	200-205
24750915-3	2012	The results demonstrated that C. kwangsiensis polysaccharides can significantly inhibit the proliferation of CNE-2 cells, which was possibly through the induction of apoptosis mediated by attenuating Bcl-2 expression and promoting p53 expression.	Polysaccharides	46-61	tumor protein p53	Homo sapiens	231-234
24750936-1	2012	In current study, a water-soluble polysaccharide (GP-I), with a molecular mass of 33 kDa, was purified from Gynostemma pentaphyllum.	Polysaccharides	34-48	glucose-6-phosphate isomerase	Homo sapiens	50-54
22234957-2	2012	We have previously hypothesized that MTG is secreted from the presynaptic terminal to reside in the synaptic cleft, where it binds glycans to organize the heavily glycosylated, extracellular synaptomatrix required for transsynaptic signaling between neuron and muscle.	Polysaccharides	131-138	mind the gap	Drosophila melanogaster	37-40
22234957-7	2012	In further testing CBD requirements, we show that MTG binds N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner, and thereby binds HRP-epitope glycans, but that these carbohydrate interactions do not require the CBD.	Polysaccharides	149-156	mind the gap	Drosophila melanogaster	50-53
22234957-8	2012	We conclude that the MTG lectin has both positive and negative binding interactions with glycans in the extracellular synaptic domain, which both facilitate and limit GluR localization during NMJ embryonic synaptogenesis.	Polysaccharides	89-96	mind the gap	Drosophila melanogaster	21-24
22234957-8	2012	We conclude that the MTG lectin has both positive and negative binding interactions with glycans in the extracellular synaptic domain, which both facilitate and limit GluR localization during NMJ embryonic synaptogenesis.	Polysaccharides	89-96	lectin-37Db	Drosophila melanogaster	25-31
22234957-8	2012	We conclude that the MTG lectin has both positive and negative binding interactions with glycans in the extracellular synaptic domain, which both facilitate and limit GluR localization during NMJ embryonic synaptogenesis.	Polysaccharides	89-96	Glutamate receptor IIA	Drosophila melanogaster	167-171
22632844-7	2012	Cheese stays much longer in contact with tooth surface than does" milk and bovine lactoferrin has four glycan chains that may contribute to a better adherence.	Polysaccharides	103-109	lactotransferrin	Bos taurus	82-93
22492204-2	2012	Most of the protein drugs developed so far, such as immunoglobulins and erythropoietin, are secreted glycoproteins; as a result, any non-human-type glycans, such as alphaGal and NeuGc, derived from animal cells and sera must be removed to circumvent undesirable immunogenic reactions.	Polysaccharides	148-155	erythropoietin	Homo sapiens	72-86
22581805-4	2012	Muc2 from the distal colon of WT and C3Gnt(-/-) knockout mice carried a mixture of core 1- or core 2-type glycans, whereas Muc2 from IEC C1Galt1(-/-) mice carried highly sialylated core 3- and core 4-type glycans.	Polysaccharides	106-113	mucin 2	Mus musculus	0-4
22576004-8	2012	These data reveal the interaction of C1INH with a wide range of enteric bacterial LPS and strongly suggest that the interaction between C1INH and the surface of Gram-negative microorganisms is determined by the length of the polysaccharide chain of the endotoxin molecule.	Polysaccharides	225-239	serpin family G member 1	Homo sapiens	37-42
22576004-8	2012	These data reveal the interaction of C1INH with a wide range of enteric bacterial LPS and strongly suggest that the interaction between C1INH and the surface of Gram-negative microorganisms is determined by the length of the polysaccharide chain of the endotoxin molecule.	Polysaccharides	225-239	serpin family G member 1	Homo sapiens	136-141
22742452-7	2012	Our in silico screen identified a new, non-polysaccharide scaffold able to interact with the heparin binding domain of antithrombin.	Polysaccharides	43-57	serpin family C member 1	Homo sapiens	119-131
22658659-10	2012	Residual polysaccharide was reduced to 1.61 mug/mg rHSA and the degree of coloring was lower than that of plasma-derived HSA.	Polysaccharides	9-23	CD24 molecule	Rattus norvegicus	51-55
22645128-3	2012	Moreover, by shielding the peptide backbone, glycans can block attempts to generate neutralizing antibodies against a substantial subset of potential epitopes when Env proteins are used as immunogens.	Polysaccharides	45-52	endogenous retrovirus group K member 20	Homo sapiens	164-167
22645128-9	2012	The glycan-depleted Env trimers should be useful for structural and immunogenicity studies.	Polysaccharides	4-10	endogenous retrovirus group K member 20	Homo sapiens	20-23
22594947-7	2012	In addition, glycan analysis of haptoglobin, transferrin, and alpha1 antitrypsin reported similar findings, although these changes did not reach significance.	Polysaccharides	13-19	haptoglobin	Homo sapiens	32-43
22594947-7	2012	In addition, glycan analysis of haptoglobin, transferrin, and alpha1 antitrypsin reported similar findings, although these changes did not reach significance.	Polysaccharides	13-19	serpin family A member 1	Homo sapiens	62-80
22488791-0	2012	Polymer pen lithography (PPL)-induced site-specific click chemistry for the formation of functional glycan arrays.	Polysaccharides	100-106	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	8-11
22658659-10	2012	Residual polysaccharide was reduced to 1.61 mug/mg rHSA and the degree of coloring was lower than that of plasma-derived HSA.	Polysaccharides	9-23	CD24 molecule	Rattus norvegicus	52-55
22585055-2	2012	With these commonly used polysaccharide CSPs, 17 PCBs except PCB 135 (R(S) = 0.81) were well resolved (R(S) &gt; 1.5) under appropriate mobile phases and temperatures.	Polysaccharides	25-39	pyruvate carboxylase	Homo sapiens	49-52
22783271-2	2012	In some cases the functional significance of a particular cell wall type appears to be easy to discern: secondary cells walls are often reinforced with lignin that provides durability; the thin cell walls of pollen tubes have particular compositions that enable their tip growth; lupin seed cell walls are characteristically thickened with galactan used as a storage polysaccharide.	Polysaccharides	367-381	5'-nucleotidase, cytosolic IIIA	Homo sapiens	280-285
22446378-6	2012	RNA-knockdown and forced expression experiments were performed to demonstrate the contribution of HEC-GlcNAc6ST to the 6-sulfated glycan expression.	Polysaccharides	130-136	carbohydrate sulfotransferase 4	Homo sapiens	98-111
22753720-1	2012	BACKGROUND/AIM: Protein-bound polysaccharide-K (PSK) is extracted from Coriolus versicolor (CM101) and is clinically used in combination therapy for gastrointestinal cancer and small-cell lung carcinoma.	Polysaccharides	30-44	TAO kinase 2	Homo sapiens	48-51
22465033-9	2012	These findings confirm an important role for lysosomal di-N-acetylchitobiase in glycans degradation and suggest that its deficiency could be the cause of a not yet described lysosomal storage disease.	Polysaccharides	80-87	chitobiase	Mus musculus	55-76
24750858-4	2012	Several structural fragments such as AraHex2-HexA-HexNAc, Hex4HexNAc2, AraHex4HexNAc, Hex10HexNAc and Hex4HexNAc-Asn were identified from MALDI-TOF spectrum; using 1D and 2D NMR spectra, the linkage site of amino acids and polysaccharides was determined as N-linked (Hex)n-GlcNAc-Asn.	Polysaccharides	223-238	hematopoietically expressed homeobox	Homo sapiens	40-43
22252477-2	2012	The Lec1 mutant, which is defective in Golgi N-acetylglucosaminyltransferase I (GnTI) activity, produces relatively homogeneous Man(5) GlcNAc(2) glycan modifications, and is widely used for various applications.	Polysaccharides	145-151	adhesion G protein-coupled receptor L2	Homo sapiens	4-8
22252477-2	2012	The Lec1 mutant, which is defective in Golgi N-acetylglucosaminyltransferase I (GnTI) activity, produces relatively homogeneous Man(5) GlcNAc(2) glycan modifications, and is widely used for various applications.	Polysaccharides	145-151	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	80-84
24750884-1	2012	Two acidic polysaccharides (GP-B1 and GP-C1) were obtained from Gynostemma pentaphyllum.	Polysaccharides	11-26	glypican 1	Homo sapiens	38-43
22492235-1	2012	The GDP-fucose transporter SLC35C1 critically regulates the fucosylation of glycans.	Polysaccharides	76-83	GDP-fucose transporter 1	Cricetulus griseus	27-34
22459802-14	2012	A short HPLC profiling method was developed for the separation of IgG glycans (biantennary G0, G1, G2, mono- and disialylated), which facilitated the determination of GalT-1 and ST-6 activities in a rapid manner.	Polysaccharides	70-77	CD82 molecule	Homo sapiens	178-182
22369936-0	2012	The glycan-binding properties of the cation-independent mannose 6-phosphate receptor are evolutionary conserved in vertebrates.	Polysaccharides	4-10	insulin like growth factor 2 receptor	Bos taurus	37-84
22552778-1	2012	PSK, a protein-bound polysaccharide, is widely used in Japan as an immunopotentiating             biological response modifier for cancer patients.	Polysaccharides	21-35	TAO kinase 2	Homo sapiens	0-3
22369936-5	2012	The results demonstrate that the D. rerio CI-MPR harbors three glycan-binding sites that, like the bovine CI-MPR, map to domains 3, 5 and 9 of its 15-domain-containing extracytoplasmic region.	Polysaccharides	63-69	insulin-like growth factor 2 receptor	Danio rerio	42-48
22369936-5	2012	The results demonstrate that the D. rerio CI-MPR harbors three glycan-binding sites that, like the bovine CI-MPR, map to domains 3, 5 and 9 of its 15-domain-containing extracytoplasmic region.	Polysaccharides	63-69	insulin like growth factor 2 receptor	Bos taurus	106-112
22369936-6	2012	Analyses on a phosphorylated glycan microarray further demonstrated the unique binding properties of each of the three sites and showed that, similar to the bovine CI-MPR, only domain 5 of the D. rerio CI-MPR is capable of recognizing Man-P-GlcNAc-containing glycans.	Polysaccharides	259-266	insulin-like growth factor 2 receptor	Danio rerio	202-208
22492235-6	2012	In contrast to the CST and UDP-galactose transporter, the C-terminal tail of SLC35C1 is not required for its Golgi localization but is essential for generating glycans that are recognized by a fucose-binding lectin, Aleuria aurantia lectin (AAL), suggesting an important role in the transport activity of SLC35C1.	Polysaccharides	160-167	GDP-fucose transporter 1	Cricetulus griseus	77-84
22496542-1	2012	Dermatan sulfate epimerase 2 (DS-epi2), together with its homolog DS-epi1, transform glucuronic acid into iduronic acid in DS polysaccharide chains.	Polysaccharides	126-140	dermatan sulfate epimerase-like	Mus musculus	0-28
22496542-1	2012	Dermatan sulfate epimerase 2 (DS-epi2), together with its homolog DS-epi1, transform glucuronic acid into iduronic acid in DS polysaccharide chains.	Polysaccharides	126-140	dermatan sulfate epimerase-like	Mus musculus	30-37
22496542-1	2012	Dermatan sulfate epimerase 2 (DS-epi2), together with its homolog DS-epi1, transform glucuronic acid into iduronic acid in DS polysaccharide chains.	Polysaccharides	126-140	dermatan sulfate epimerase	Mus musculus	66-73
22632037-7	2012	Insulin, calcitonin and heparin were mainly focused for the discussion as they could represent protein, polypeptide and polysaccharide drugs, respectively.	Polysaccharides	120-134	insulin	Homo sapiens	0-7
22549776-1	2012	Many functions of galectin-3 entail binding of its carbohydrate recognition site to glycans of a glycoprotein, resulting in cross-linking thought to be mediated by its N-terminal noncarbohydrate-binding domain.	Polysaccharides	84-91	galectin 3	Homo sapiens	18-28
22579869-1	2012	In this study, a water-soluble polysaccharide (PPS) from Dictyophora indusiata was purified and investigated through a combination of gel chromatography (Sephadex G-200), infrared (IR) spectroscopy, and gas chromatography-mass spectrometry (GC-MS).	Polysaccharides	31-45	inositol polyphosphate-5-phosphatase K	Homo sapiens	47-50
22278669-7	2012	also interact with B4galnt2 glycans.	Polysaccharides	28-35	beta-1,4-N-acetyl-galactosaminyl transferase 2	Mus musculus	19-27
22147756-6	2012	In contrast, cell walls of CAD-RNAi midribs present a reduction in the total lignin content and of cell wall polysaccharides.	Polysaccharides	109-124	probable cinnamyl alcohol dehydrogenase	Zea mays	27-30
22802576-4	2012	In patients with IgAN, circulating IgA1 molecules have an aberrant structure of O-glycans in the hinge region, which is characterized by abbreviated glycans composed of N-acetylgalactosamine, with or without sialic acid.	Polysaccharides	82-89	IGAN1	Homo sapiens	17-21
22802576-4	2012	In patients with IgAN, circulating IgA1 molecules have an aberrant structure of O-glycans in the hinge region, which is characterized by abbreviated glycans composed of N-acetylgalactosamine, with or without sialic acid.	Polysaccharides	82-89	immunoglobulin heavy constant alpha 1	Homo sapiens	35-39
22549776-3	2012	Surprisingly, in the presence of ASF, this remained low even at high galectin-3 concentrations, showing that many more galectin-3 molecules were engaged than expected due to the about nine known glycan-based binding sites per ASF molecule.	Polysaccharides	195-201	galectin 3	Homo sapiens	119-129
22628288-3	2012	Among these, the monoclonal antibody 2G12 binds to clusters of high-mannose-type glycans that are present on the surface of gp120.	Polysaccharides	81-88	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	124-129
22444368-1	2012	Mucin glycoproteins present a complex structural landscape arising from the multiplicity of glycosylation patterns afforded by their numerous serine and threonine glycosylation sites, often in clusters, and with variations in respective glycans.	Polysaccharides	237-244	LOC100508689	Homo sapiens	0-5
22728372-0	2012	Astragalus polysaccharide improves palmitate-induced insulin resistance by inhibiting PTP1B and NF-kappaB in C2C12 myotubes.	Polysaccharides	11-25	nuclear factor kappa B subunit 1	Homo sapiens	96-105
22540968-8	2012	We observed direct evidence for galectin-1-mediated extended cross-linking on the engineered cells, a phenomenon that was dependent on glycan structure.	Polysaccharides	135-141	galectin 1	Homo sapiens	32-42
22728372-0	2012	Astragalus polysaccharide improves palmitate-induced insulin resistance by inhibiting PTP1B and NF-kappaB in C2C12 myotubes.	Polysaccharides	11-25	insulin	Homo sapiens	53-60
22728372-6	2012	The results of the present study suggest that Astragalus polysaccharide inhibits palmitate-induced insulin resistance in C2C12 myotubes by inhibiting expression of PTP1B and regulating NF-kappaB but not AMPK pathway.	Polysaccharides	57-71	insulin	Homo sapiens	99-106
22728372-0	2012	Astragalus polysaccharide improves palmitate-induced insulin resistance by inhibiting PTP1B and NF-kappaB in C2C12 myotubes.	Polysaccharides	11-25	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	86-91
22728372-6	2012	The results of the present study suggest that Astragalus polysaccharide inhibits palmitate-induced insulin resistance in C2C12 myotubes by inhibiting expression of PTP1B and regulating NF-kappaB but not AMPK pathway.	Polysaccharides	57-71	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	164-169
22728372-6	2012	The results of the present study suggest that Astragalus polysaccharide inhibits palmitate-induced insulin resistance in C2C12 myotubes by inhibiting expression of PTP1B and regulating NF-kappaB but not AMPK pathway.	Polysaccharides	57-71	nuclear factor kappa B subunit 1	Homo sapiens	185-194
24750599-1	2012	Current study we purified a polysaccharide (BRP) from Boschniakia rossica and the antitumor effects of BRP alone or combined with 5-Fluorouracil (5-FU) was examined in S180 tumor bearing mice by intragastric administration.	Polysaccharides	28-42	growth differentiation factor 5	Mus musculus	44-47
22574931-6	2012	Surprisingly, ST6Gal1 sialylated the two termini of the complex-type binantennary glycan in a manner remarkably similar to that observed for the free N-glycan, suggesting the Fc polypeptide does not greatly influence ST6Gal1 specificity.	Polysaccharides	82-88	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	14-21
24750599-2	2012	The high performance size-exclusion chromatography (HPGEC) analysis showed that BRP was a homogeneous polysaccharide and had a molecular weight of 2.2 x 10(4) Da.	Polysaccharides	102-116	growth differentiation factor 5	Mus musculus	80-83
22690374-7	2012	Our data suggest an intriguing possibility that beta4GalNAcTA may participate in the biosynthesis of sialylated glycans.	Polysaccharides	112-119	beta1,4-N-acetylgalactosaminyltransferase A	Drosophila melanogaster	48-61
22494465-1	2012	We examined the mechanism of accumulation of charged polynuclear platinum complexes (PPCs) based on analogy of polyarginine interactions with the cell surface heparan sulfate proteoglycan (HSPG) family of protein-linked glycosoaminoglycan polysaccharides (GAGs).	Polysaccharides	239-254	syndecan 2	Homo sapiens	189-193
22665612-2	2012	Antibodies to Hib capsular polysaccharide (PRP) were measured in infants and toddlers from an area already served by the Hib immunization program (Bamako) and in unimmunized children of the same age in a district (Kangaba) where Hib immunization had not yet begun.	Polysaccharides	27-41	prion protein	Homo sapiens	43-46
22490318-5	2012	On the other hand, increased levels of a tetra-antennary glycan were observed in the HCC tissue as compared with the surrounding tissue or to the nondiseased livers.	Polysaccharides	57-63	HCC	Homo sapiens	85-88
22490318-7	2012	IMPACT: The identification of increased levels of tetra-antennary glycan on liver tumor tissue, as opposed to adjacent or nondiseased tissue may lead to improved detection of HCC.	Polysaccharides	66-72	HCC	Homo sapiens	175-178
22652666-7	2012	TLR engagement augments BAFF mediated PS antibody responses and TLR ligands serve as adjuvants for induction of anti-PS antibodies either for pure PS or for PS-protein conjugate vaccines.	Polysaccharides	38-40	TNF superfamily member 13b	Homo sapiens	24-28
22183981-2	2012	Mucin-type O-glycosylation, consisting of glycans attached via O-linked N-acetylgalactosamine (GalNAc) to serine and threonine residues, is one of the most abundant forms of protein glycosylation in animals.	Polysaccharides	42-49	LOC100508689	Homo sapiens	0-5
22709487-5	2012	In peptidoglycan/polysaccharide-induced polyarthritis, proteasome inhibitors limit the overall inflammation, reduce NF-kappaB activation, decrease cellular adhesion molecule expression, inhibit nitric oxide synthase, attenuate circulating levels of proinflammatory cytokine interleukin-6 and reduce the arthritis index and swelling in the joints of the animals.	Polysaccharides	17-31	nuclear factor kappa B subunit 1	Homo sapiens	116-125
22183981-3	2012	Although most protein glycosylation is controlled by one or two genes encoding the enzymes responsible for the initiation of glycosylation, i.e. the step where the first glycan is attached to the relevant amino acid residue in the protein, mucin-type O-glycosylation is controlled by a large family of up to 20 homologous genes encoding UDP-GalNAc:polypeptide GalNAc-transferases (GalNAc-Ts) (EC 2.4.1.41).	Polysaccharides	170-176	LOC100508689	Homo sapiens	240-245
22709487-5	2012	In peptidoglycan/polysaccharide-induced polyarthritis, proteasome inhibitors limit the overall inflammation, reduce NF-kappaB activation, decrease cellular adhesion molecule expression, inhibit nitric oxide synthase, attenuate circulating levels of proinflammatory cytokine interleukin-6 and reduce the arthritis index and swelling in the joints of the animals.	Polysaccharides	17-31	interleukin 6	Homo sapiens	274-287
23236833-2	2012	METHODS: Investigated the effects of polysaccharide extracted from root of Salvia miltiorrhiza on lymphocyte proliferation response of mouse induced by LPS (the lipopolysaccharide LPS), phagocytosis of the peritoneal macrophage of mice to chick erythrocytes and the mouse models of delayed type hypersensitivity (DTH) response induced by DNFB.	Polysaccharides	37-51	toll-like receptor 4	Mus musculus	152-155
22334022-4	2012	We have developed a delivery system for antisense ODN using schizophyllan (SPG), a polysaccharide that belongs to the beta-(1-3) glucan family.	Polysaccharides	83-97	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	118-127
22022932-9	2012	NEU2, formerly known as sialidase 2, belongs to a family of enzymes that cleave sialic acid from polysaccharide chains.	Polysaccharides	97-111	neuraminidase 2	Equus caballus	0-4
23236833-2	2012	METHODS: Investigated the effects of polysaccharide extracted from root of Salvia miltiorrhiza on lymphocyte proliferation response of mouse induced by LPS (the lipopolysaccharide LPS), phagocytosis of the peritoneal macrophage of mice to chick erythrocytes and the mouse models of delayed type hypersensitivity (DTH) response induced by DNFB.	Polysaccharides	37-51	toll-like receptor 4	Mus musculus	180-183
22366522-0	2012	Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells.	Polysaccharides	0-6	CD4 molecule	Homo sapiens	32-35
21780104-0	2012	alpha1-3/4 fucosylation at Asn 241 of beta-haptoglobin is a novel marker for colon cancer: a combinatorial approach for development of glycan biomarkers.	Polysaccharides	135-141	adrenoceptor alpha 1D	Homo sapiens	0-8
22366522-0	2012	Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells.	Polysaccharides	0-6	CD8a molecule	Homo sapiens	41-44
22551306-2	2012	Plant lectins such as phytohemagluttinin (PHA) can activate the T cell receptor (TCR) and other cell-surface receptors by binding to glycans and initiating receptor cross-linking.	Polysaccharides	133-140	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	64-79
22551306-2	2012	Plant lectins such as phytohemagluttinin (PHA) can activate the T cell receptor (TCR) and other cell-surface receptors by binding to glycans and initiating receptor cross-linking.	Polysaccharides	133-140	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	81-84
22551306-11	2012	Comparison of lectin signaling through TCR or CD8zeta allows us to better define the structural and functional properties of lectin-glycan interactions using a biologically based signaling readout.	Polysaccharides	132-138	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	39-42
22451653-5	2012	Both the recognition of sialylated glycans by the Siglec-15 V-set domain and the association with DAP12 through its Lys-272 are essential for its function.	Polysaccharides	35-42	sialic acid binding Ig-like lectin 15	Mus musculus	50-59
22451653-5	2012	Both the recognition of sialylated glycans by the Siglec-15 V-set domain and the association with DAP12 through its Lys-272 are essential for its function.	Polysaccharides	35-42	TYRO protein tyrosine kinase binding protein	Mus musculus	98-103
21780104-6	2012	Reactivity with fucosylated glycans was eliminated by treatment with alpha1-3/4 fucosidase but not alpha1-6 fucosidase, indicating that enhanced lectin reactivity with the fucose moiety of colon cancer beta-Hp is due to Fucalpha1-3/4GlcNAc.	Polysaccharides	28-35	adrenoceptor alpha 1D	Homo sapiens	69-77
22562786-0	2012	Analysis of the neutral polysaccharide fraction of MCP and its inhibitory activity on galectin-3.	Polysaccharides	24-38	galectin 3	Homo sapiens	86-96
22547820-7	2012	These results reveal a unique reversible kinetic mechanism for neutralization by an antibody that binds near a critical V3 region in the glycan shield of gp120.	Polysaccharides	137-143	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	154-159
22331432-0	2012	Difference in fine specificity to polysaccharides of Candida albicans mannoprotein between mouse SIGNR1 and human DC-SIGN.	Polysaccharides	34-49	CD209b antigen	Mus musculus	97-103
22331432-1	2012	C-type lectin SIGNR1 directly recognizes Candida albicans and zymosan and has been considered to share properties of polysaccharide recognition with human DC-SIGN (hDC-SIGN).	Polysaccharides	117-131	CD209b antigen	Mus musculus	14-20
22331432-5	2012	Inhibition analyses of sSIGNR1 binding by glycans from various yeast strains demonstrated that SIGNR1 preferentially recognizes N-glycan alpha-mannose side chains in Candida mannoproteins, as reported in hDC-SIGN.	Polysaccharides	42-49	CD209b antigen	Mus musculus	24-30
22330910-6	2012	By using a battery of LPS-truncated E. coli mutant strains, we demonstrate that the polysaccharide moiety of LPS is essential for ECP-mediated bacterial agglutination, thereby modulating its antimicrobial action.	Polysaccharides	84-98	ribonuclease A family member 3	Homo sapiens	130-133
22330910-7	2012	The mechanism of action of ECP at the bacterial surface is drastically affected by the LPS structure and in particular by its polysaccharide moiety.	Polysaccharides	126-140	ribonuclease A family member 3	Homo sapiens	27-30
22764522-9	2012	Thus these results show that the N-linked glycosylation in the prME and NS1 gene were correlated with the immunity, one glycan absent would enhance the immunity but both two loss would impair it.	Polysaccharides	120-126	influenza virus NS1A binding protein	Homo sapiens	72-75
22459924-1	2012	A water-soluble polysaccharide (FUP-1) was obtained from Fritillaria ussuriensis Maxim through warm water extraction, ethanol precipitation, anion-exchange and gel-permeation chromatography.	Polysaccharides	16-30	BTB (POZ) domain containing 7	Mus musculus	32-37
22467657-4	2012	The siglec ligand glycans in normal colonic epithelial cells included disialyl Lewis(a), which was found to have binding activity to both siglec-7 and -9, and sialyl 6-sulfo Lewis(x), which exhibited significant binding to siglec-7.	Polysaccharides	18-25	sialic acid binding Ig like lectin 7	Homo sapiens	138-153
22467657-4	2012	The siglec ligand glycans in normal colonic epithelial cells included disialyl Lewis(a), which was found to have binding activity to both siglec-7 and -9, and sialyl 6-sulfo Lewis(x), which exhibited significant binding to siglec-7.	Polysaccharides	18-25	sialic acid binding Ig like lectin 7	Homo sapiens	138-146
22467657-9	2012	These results suggest that normal glycans of epithelial cells exert a suppressive effect on cyclooxygenase-2 expression by resident macrophages, thus maintaining immunological homeostasis in colonic mucosal membranes.	Polysaccharides	34-41	prostaglandin-endoperoxide synthase 2	Homo sapiens	92-108
22562786-11	2012	The information provided in this paper is valuable for screening more active galectin-3 inhibitors from natural polysaccharides.	Polysaccharides	112-127	galectin 3	Homo sapiens	77-87
22438544-4	2012	In this study, we determined glycan-binding specificities of the MNV strains MNV-1 and CR3 in vitro, identified molecular determinants of glycan binding, and analyzed infection in vivo.	Polysaccharides	29-35	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	87-90
22144071-3	2012	The aim of this study was to investigate the immunomodulatory and antioxidant effects of polysaccharides from red mould rice (RMRP) and red mould dioscorea (RMDP) in Raw 264.7 cells.	Polysaccharides	89-104	RNA component of mitochondrial RNAase P	Mus musculus	126-130
22328055-8	2012	Co-immunoprecipitation studies demonstrated that OS9 associates with Arabidopsis SEL1L/HRD3, which is part of the plant ERAD complex and with the ERAD substrates BRI1-5 and BRI1-9, but only the binding to BRI1-5 occurs in a glycan-dependent way.	Polysaccharides	224-230	ER lectin-like protein	Arabidopsis thaliana	49-52
22522420-7	2012	Finally, we show that recessive mutations in ISPD abolish the initial step in laminin-binding glycan synthesis by disrupting dystroglycan O-mannosylation.	Polysaccharides	94-100	CDP-L-ribitol pyrophosphorylase A	Homo sapiens	45-49
22522458-5	2012	We subsequently showed how heparin and a high-molecular-weight Escherichia coli K5-derived heparin-like polysaccharide (K5-NSOS) inhibited TGF-beta-induced IL-11 production in MDA-MB-231(SA) cells.	Polysaccharides	104-118	transforming growth factor beta 1	Homo sapiens	139-147
22522458-5	2012	We subsequently showed how heparin and a high-molecular-weight Escherichia coli K5-derived heparin-like polysaccharide (K5-NSOS) inhibited TGF-beta-induced IL-11 production in MDA-MB-231(SA) cells.	Polysaccharides	104-118	interleukin 11	Homo sapiens	156-161
22328055-8	2012	Co-immunoprecipitation studies demonstrated that OS9 associates with Arabidopsis SEL1L/HRD3, which is part of the plant ERAD complex and with the ERAD substrates BRI1-5 and BRI1-9, but only the binding to BRI1-5 occurs in a glycan-dependent way.	Polysaccharides	224-230	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	162-166
22328055-8	2012	Co-immunoprecipitation studies demonstrated that OS9 associates with Arabidopsis SEL1L/HRD3, which is part of the plant ERAD complex and with the ERAD substrates BRI1-5 and BRI1-9, but only the binding to BRI1-5 occurs in a glycan-dependent way.	Polysaccharides	224-230	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	162-168
22032286-8	2012	CONCLUSIONS: These findings provide direct evidence that R154 in the context of full-length CTL2 is both necessary and sufficient to create the HNA-3a epitope but suggest that posttranslational modifications of the protein, for example, S-S bonds or addition of glycans, are necessary for recognition of HNA-3a by many antibodies.	Polysaccharides	262-269	solute carrier family 44 member 2	Homo sapiens	92-96
22329400-4	2012	Results show that (i) the radiolabeled mucin glycoproteins of each of the cancer cell lines studied (T47D, MCF7, LS180, LNCaP, SKOV3, HL60, DU4475, and HepG2) is distinct either in terms of the specific glycans presented or their relative distribution.	Polysaccharides	203-210	LOC100508689	Homo sapiens	39-44
22370430-1	2012	Human vascular endocan is a proteoglycan exhibiting tumorigenic activity through both its glycan and protein cores.	Polysaccharides	34-40	endothelial cell specific molecule 1	Homo sapiens	15-22
21984514-5	2012	Inhibition of MMP activation with sub-antimicrobial doses of doxycycline, or zinc chelators, has also inhibited WBC adhesion and shedding of glycans from the EC surface in response to the chemoattractant fMLP.	Polysaccharides	141-148	formyl peptide receptor 1	Homo sapiens	204-208
22431632-3	2012	3-OST is present in multiple isoforms, and the polysaccharides modified by these different isoforms perform distinct biological functions.	Polysaccharides	47-62	heparan sulfate-glucosamine 3-sulfotransferase 1	Homo sapiens	0-5
22288421-0	2012	T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival.	Polysaccharides	17-24	sialophorin	Homo sapiens	28-32
22288421-3	2012	Global T cell glycosylation and specific glycosylation of CD43 and CD45 are modulated during thymocyte development and T cell activation; T cells control the type and abundance of glycans decorating CD43 and CD45 by regulating expression of glycosyltransferases and glycosidases.	Polysaccharides	180-187	sialophorin	Homo sapiens	199-203
22288421-3	2012	Global T cell glycosylation and specific glycosylation of CD43 and CD45 are modulated during thymocyte development and T cell activation; T cells control the type and abundance of glycans decorating CD43 and CD45 by regulating expression of glycosyltransferases and glycosidases.	Polysaccharides	180-187	protein tyrosine phosphatase receptor type C	Homo sapiens	208-212
22288421-4	2012	Additionally, T cells regulate glycosylation of CD45 by expressing alternatively spliced isoforms of CD45 that have different glycan attachment sites.	Polysaccharides	126-132	protein tyrosine phosphatase receptor type C	Homo sapiens	48-52
22288421-4	2012	Additionally, T cells regulate glycosylation of CD45 by expressing alternatively spliced isoforms of CD45 that have different glycan attachment sites.	Polysaccharides	126-132	protein tyrosine phosphatase receptor type C	Homo sapiens	101-105
22524424-4	2012	Recent works suggest that complex glycans of gp120 are recognized by another host lectin, galectin-1.	Polysaccharides	34-41	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	45-50
22524424-4	2012	Recent works suggest that complex glycans of gp120 are recognized by another host lectin, galectin-1.	Polysaccharides	34-41	galectin 1	Homo sapiens	90-100
22068886-8	2012	We have developed a technology called "Glycosyltransferase-Programmed Stereosubstitution" (GPS) for custom-modifying CD44 glycans to create HCELL on the surface of living cells.	Polysaccharides	122-129	CD44 molecule (Indian blood group)	Homo sapiens	117-121
22288459-8	2012	In fact, the Fc glycan composition dictates IgG affinity to individual FcgammaRs, and in a broader sense, binding to different FcgammaRs classes: activating, inhibitory, and anti-inflammatory (dendritic cell-specific ICAM-3 grabbing nonintegrin, DC-SIGN).	Polysaccharides	16-22	intercellular adhesion molecule 3	Homo sapiens	217-223
22288521-4	2012	Further studies revealed that the homing of the CD4(+)CD25(+) regulatory T cells to the NALT is dependent not only on the L-selectin-sulfated glycan interaction but also on P-selectin glycoprotein ligand-1 and CD44.	Polysaccharides	142-148	CD4 antigen	Mus musculus	48-51
22288521-4	2012	Further studies revealed that the homing of the CD4(+)CD25(+) regulatory T cells to the NALT is dependent not only on the L-selectin-sulfated glycan interaction but also on P-selectin glycoprotein ligand-1 and CD44.	Polysaccharides	142-148	interleukin 2 receptor, alpha chain	Mus musculus	54-58
22288521-6	2012	Recent studies indicated that the L-selectin-sulfated glycan interaction is also important for lymphocyte homing in chronic inflammation.	Polysaccharides	54-60	selectin, lymphocyte	Mus musculus	34-44
22068886-11	2012	This review presents an historical framework of the homing receptor concept, and will describe the discovery of HCELL, its function as the bone marrow homing receptor, and how enforced expression of this molecule via chemical engineering of CD44 glycans could enable stem cell-based regenerative medicine and other adoptive cell therapeutics.	Polysaccharides	246-253	CD44 molecule (Indian blood group)	Homo sapiens	241-245
22267483-2	2012	Here, we explored its interaction with the glycan-binding proteins galectin-1 and galectin-3.	Polysaccharides	43-49	lectin, galactose binding, soluble 1	Mus musculus	67-77
22391968-4	2012	Modifications in the lignocellulose macrocomponents associated with this non-enzymatic attack are believed to aid in the selective, near-complete removal of polysaccharides by an incomplete cellulase suite and without causing substantial lignin removal.	Polysaccharides	157-172	activation induced cytidine deaminase	Homo sapiens	110-113
22524424-6	2012	The peculiar presentation of complex glycans on gp120 seems to impart specificity for galectin-1, as another member of the same family, galectin-3, is unable to bind gp120 or enhance HIV-1 infection.	Polysaccharides	37-44	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	48-53
22524424-6	2012	The peculiar presentation of complex glycans on gp120 seems to impart specificity for galectin-1, as another member of the same family, galectin-3, is unable to bind gp120 or enhance HIV-1 infection.	Polysaccharides	37-44	galectin 1	Homo sapiens	86-96
22267483-2	2012	Here, we explored its interaction with the glycan-binding proteins galectin-1 and galectin-3.	Polysaccharides	43-49	lectin, galactose binding, soluble 3	Mus musculus	82-92
22418768-3	2012	alpha-Gal is a ubiquitous glycan moiety expressed on cells and tissue of non-primate mammals.	Polysaccharides	26-32	glycoprotein galactosyltransferase alpha 1, 3	Mus musculus	0-9
22156919-7	2012	Overall, our findings contribute to better understanding interactions of gal-1 with larger, complex polysaccharides and to the development of GM-based therapeutics for clinical use.	Polysaccharides	100-115	galectin 1	Homo sapiens	73-78
22299597-1	2012	The semi-synthetic sulfated polysaccharide PPS (pentosan polysulfate) increases affinity between the aggrecan-degrading ADAMTSs (adamalysins with thrombospondin motifs) and their endogenous inhibitor, TIMP (tissue inhibitor of metalloproteinases)-3.	Polysaccharides	28-42	TIMP metallopeptidase inhibitor 1	Homo sapiens	201-205
22299597-1	2012	The semi-synthetic sulfated polysaccharide PPS (pentosan polysulfate) increases affinity between the aggrecan-degrading ADAMTSs (adamalysins with thrombospondin motifs) and their endogenous inhibitor, TIMP (tissue inhibitor of metalloproteinases)-3.	Polysaccharides	28-42	TIMP metallopeptidase inhibitor 3	Homo sapiens	207-248
22197795-0	2012	A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression.	Polysaccharides	2-17	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	18-23
22053055-8	2012	These results suggest that macrophage-derived factors including LIF might facilitate development of an implantation-receptive endometrium by regulating surface glycan structures in epithelial cells.	Polysaccharides	160-166	LIF interleukin 6 family cytokine	Homo sapiens	64-67
22197795-0	2012	A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression.	Polysaccharides	2-17	sphingosine-1-phosphate receptor 1	Homo sapiens	92-96
22391090-0	2012	Macrophage immunomodulatory activity of extracellular polysaccharide (PEP) of Antarctic bacterium Pseudoaltermonas sp.S-5.	Polysaccharides	54-68	progestagen associated endometrial protein	Homo sapiens	70-73
22391090-8	2012	At 200 mug/ml PEP caused a greatest increase (44.5%) in NO production when compared to the control group; however, this polysaccharide did not affect respiratory burst in the absence of PMA.	Polysaccharides	120-134	progestagen associated endometrial protein	Homo sapiens	14-17
22133665-0	2012	An immunostimulatory polysaccharide (SCP-IIa) from the fruit of Schisandra chinensis (Turcz.)	Polysaccharides	21-35	ATPase, class II, type 9A	Mus musculus	41-44
22133665-2	2012	A water-soluble polysaccharide named SCP-IIa was isolated from the water extract of the fruit of Schisandra chinensis (Turcz.)	Polysaccharides	16-30	ATPase, class II, type 9A	Mus musculus	41-44
22133665-5	2012	SCP-IIa was a homogeneous form of polysaccharide, with an average molecular weight of approximately 7700 Da.	Polysaccharides	34-48	ATPase, class II, type 9A	Mus musculus	4-7
22404596-3	2012	The 166 residue polypeptide chain of interferon-beta was prepared by covalent condensation of two synthetic peptide segments and a glycosylated synthetic peptide bearing a complex-type glycan of biological origin.	Polysaccharides	185-191	interferon beta 1	Homo sapiens	37-52
22304929-4	2012	SRD5A3 was recently identified encoding the polyprenol reductase, an enzyme catalyzing the final step of the biosynthesis of dolichol, which is required for the assembly of the glycans needed for N-glycosylation.	Polysaccharides	177-184	steroid 5 alpha-reductase 3	Homo sapiens	0-6
22304929-4	2012	SRD5A3 was recently identified encoding the polyprenol reductase, an enzyme catalyzing the final step of the biosynthesis of dolichol, which is required for the assembly of the glycans needed for N-glycosylation.	Polysaccharides	177-184	steroid 5 alpha-reductase 3	Homo sapiens	44-64
22446837-2	2012	The glycan biosynthesis was enabled by four eukaryotic glycosyltransferases, including the yeast uridine diphosphate-N-acetylglucosamine transferases Alg13 and Alg14 and the mannosyltransferases Alg1 and Alg2.	Polysaccharides	4-10	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13	Saccharomyces cerevisiae S288C	150-155
22325877-6	2012	Glycan analysis of endogenous proteins in the transgenic lines using CE-LIF showed that tri-antennary N-glycans could be produced in the XylT/FucT deficient line, while these structures were not found in the wild type background.	Polysaccharides	0-6	beta-1,2-xylosyltransferase	Arabidopsis thaliana	137-141
22325877-6	2012	Glycan analysis of endogenous proteins in the transgenic lines using CE-LIF showed that tri-antennary N-glycans could be produced in the XylT/FucT deficient line, while these structures were not found in the wild type background.	Polysaccharides	0-6	fucosyltransferase 11	Arabidopsis thaliana	142-146
22446837-2	2012	The glycan biosynthesis was enabled by four eukaryotic glycosyltransferases, including the yeast uridine diphosphate-N-acetylglucosamine transferases Alg13 and Alg14 and the mannosyltransferases Alg1 and Alg2.	Polysaccharides	4-10	chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase	Saccharomyces cerevisiae S288C	150-154
22446837-2	2012	The glycan biosynthesis was enabled by four eukaryotic glycosyltransferases, including the yeast uridine diphosphate-N-acetylglucosamine transferases Alg13 and Alg14 and the mannosyltransferases Alg1 and Alg2.	Polysaccharides	4-10	GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	204-208
22430056-6	2012	The next stage of disease development requires the formation of glycan-specific IgG and IgA antibodies that recognize the undergalactosylated IgA1 molecule.	Polysaccharides	64-70	immunoglobulin heavy constant alpha 1	Homo sapiens	142-146
22446837-2	2012	The glycan biosynthesis was enabled by four eukaryotic glycosyltransferases, including the yeast uridine diphosphate-N-acetylglucosamine transferases Alg13 and Alg14 and the mannosyltransferases Alg1 and Alg2.	Polysaccharides	4-10	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14	Saccharomyces cerevisiae S288C	160-165
22191536-9	2012	The FBP from bovine milk contains putative structures corresponding to high-mannose (Hex(4-9)HexNAc(2)) as well as hybrid and complex N-linked glycans (Hex(3-6)HexNAc(3-6)), but these glycans mostly do not contain fucose and sialic acid.	Polysaccharides	143-150	folate receptor alpha	Bos taurus	4-7
22262853-8	2012	Moreover, the efficient processing of glycans on latent TGF-beta1 to complex type structures was consistent with the lack of mannose phosphorylation during biosynthesis.	Polysaccharides	38-45	transforming growth factor beta 1	Homo sapiens	56-65
22150318-5	2012	A screen of polysaccharide and small organic molecules from medicinal plants and fungi reveals one candidate in each category, PS5 (polysaccharide 5) and ganoderic acid DM respectively, with activity against Abeta.	Polysaccharides	12-26	amyloid beta precursor protein	Homo sapiens	208-213
22150318-5	2012	A screen of polysaccharide and small organic molecules from medicinal plants and fungi reveals one candidate in each category, PS5 (polysaccharide 5) and ganoderic acid DM respectively, with activity against Abeta.	Polysaccharides	132-146	amyloid beta precursor protein	Homo sapiens	208-213
22257732-0	2012	Comparative evaluation of T11 target structure and its deglycosylated derivative nullifies the importance of glycan moieties in immunotherapeutic efficacy.	Polysaccharides	109-115	histocompatibility 2, T region locus 11, pseudogene	Mus musculus	26-29
21941373-9	2012	These studies identify a novel TRAIL-resistance mechanism in which galectin-3 impedes trafficking of death receptor by anchoring them in glycan nano-clusters, blocking the execution of the apoptosis signal.	Polysaccharides	137-143	TNF superfamily member 10	Homo sapiens	31-36
22349222-9	2012	This structural insight, together with fluorescence-assay data, confirms and explains the higher specificity of Epa1p adhesin for glycan molecules compared with the S. cerevisiae flocculins.	Polysaccharides	130-136	GTPase NPA3	Saccharomyces cerevisiae S288C	112-117
21941373-9	2012	These studies identify a novel TRAIL-resistance mechanism in which galectin-3 impedes trafficking of death receptor by anchoring them in glycan nano-clusters, blocking the execution of the apoptosis signal.	Polysaccharides	137-143	galectin 3	Homo sapiens	67-77
22490576-0	2012	Inhibiting effect of Astragalus polysaccharides on the functions of CD4+CD25 highTreg cells in the tumor microenvironment of human hepatocellular carcinoma.	Polysaccharides	32-47	interleukin 2 receptor subunit alpha	Homo sapiens	72-76
22238358-8	2012	Fer kinase regulated STAT3 phosphorylation and consequent activation, whereas knockdown of STAT3 increased laminin-binding glycan expression on cancer cells.	Polysaccharides	123-129	signal transducer and activator of transcription 3	Homo sapiens	91-96
21935947-10	2012	In isolated cones and matrix sheets, IRBP colocalized with the peanut agglutinin binding matrix glycans.	Polysaccharides	96-103	retinol binding protein 3	Sus scrofa	37-41
22407978-4	2012	The composition of the Fc glycan can have substantial impacts on Fc gamma receptor(FcgammaR) binding.	Polysaccharides	26-32	Fc gamma receptor Ia	Homo sapiens	65-92
22490576-0	2012	Inhibiting effect of Astragalus polysaccharides on the functions of CD4+CD25 highTreg cells in the tumor microenvironment of human hepatocellular carcinoma.	Polysaccharides	32-47	CD4 molecule	Homo sapiens	68-71
22131189-9	2012	In association with TGF-beta1, GY785 DRS was found to upregulate the phosphorylation of extracellular signal-regulated kinase 1/2, indicating that oversulfated polysaccharide affects the mitogen activated protein kinase signaling activity.	Polysaccharides	160-174	transforming growth factor beta 1	Homo sapiens	20-29
22131189-9	2012	In association with TGF-beta1, GY785 DRS was found to upregulate the phosphorylation of extracellular signal-regulated kinase 1/2, indicating that oversulfated polysaccharide affects the mitogen activated protein kinase signaling activity.	Polysaccharides	160-174	mitogen-activated protein kinase 3	Homo sapiens	88-129
22131189-10	2012	These results demonstrate the upregulation of TGF-beta1-dependent stem cell chondrogenesis by a chemically oversulfated marine polysaccharide.	Polysaccharides	127-141	transforming growth factor beta 1	Homo sapiens	46-55
22737923-5	2012	RESULTS: Due to the use of polysaccharides, the behavioral disturbance was improved, brain water content and the levels of serum CRP were significantly decreased.	Polysaccharides	27-42	C-reactive protein	Rattus norvegicus	129-132
22357377-2	2012	The polysaccharide constituents of Astragali Radix (ARP) are considered as one of the major constituents contributing to the multiple pharmacological effects of this medicinal plant.	Polysaccharides	4-18	ribosomal protein, large, P0	Danio rerio	52-55
22230586-4	2012	We demonstrate below that in immune responses to the diptheria/acellular pertussis/tetanus and pneumococcal polysaccharide conjugate vaccines, potentially antagonistic Th1-/IFN-associated and Th2-associated gene networks coexist in an apparent state of dynamic equilibrium, whereas in Th2-dominant allergen-specific responses of atopics the Th1 and IFN networks are respectively disrupted and downregulated.	Polysaccharides	108-122	negative elongation factor complex member C/D	Homo sapiens	168-171
22230586-4	2012	We demonstrate below that in immune responses to the diptheria/acellular pertussis/tetanus and pneumococcal polysaccharide conjugate vaccines, potentially antagonistic Th1-/IFN-associated and Th2-associated gene networks coexist in an apparent state of dynamic equilibrium, whereas in Th2-dominant allergen-specific responses of atopics the Th1 and IFN networks are respectively disrupted and downregulated.	Polysaccharides	108-122	interferon alpha 1	Homo sapiens	173-176
22230586-4	2012	We demonstrate below that in immune responses to the diptheria/acellular pertussis/tetanus and pneumococcal polysaccharide conjugate vaccines, potentially antagonistic Th1-/IFN-associated and Th2-associated gene networks coexist in an apparent state of dynamic equilibrium, whereas in Th2-dominant allergen-specific responses of atopics the Th1 and IFN networks are respectively disrupted and downregulated.	Polysaccharides	108-122	negative elongation factor complex member C/D	Homo sapiens	341-352
22229911-3	2012	We report a systematic investigation of the interaction between synthetic polymer nanoparticles and polysaccharides by ITC, SPR, and an anticoagulant assay to provide guidelines to engineer nanoparticles for biomedical applications.	Polysaccharides	100-115	sepiapterin reductase	Homo sapiens	124-127
22209231-2	2012	The lectins griffithsin (GRFT), cyanovirin-N (CV-N) and scytovirin (SVN) inhibit HIV-1 infection by binding to mannose-rich glycans on gp120.	Polysaccharides	124-131	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	135-140
22408387-9	2012	The multiple spots detected for cerebrospinal fluid transferrin were mainly due to heterogeneity of di-antennary and tri-antennary glycans harboring a varying number of terminal N-acetylneuraminic acids and the existence of a high mannose and high N-acetylhexosamine glycosylated species.	Polysaccharides	131-138	transferrin	Homo sapiens	52-63
22305527-4	2012	Here, we combined biochemical analysis with whole-exome sequencing (WES) to identify the genetic defect in an untyped CDG patient, and we found a 22 bp deletion and a missense mutation in DDOST, whose product is a component of the oligosaccharyltransferase complex that transfers the glycan chain from a lipid carrier to nascent proteins in the endoplasmic reticulum lumen.	Polysaccharides	284-290	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	188-193
22067045-7	2012	Here, we report the identification and elucidation of IgA1 O-glycopeptide structural isomers that occur based on amino acid position of the attached glycans (positional isomers) and the structure of the O-glycan chains at individual sites (glycan isomers).	Polysaccharides	149-156	immunoglobulin heavy constant alpha 1	Homo sapiens	54-58
22067045-7	2012	Here, we report the identification and elucidation of IgA1 O-glycopeptide structural isomers that occur based on amino acid position of the attached glycans (positional isomers) and the structure of the O-glycan chains at individual sites (glycan isomers).	Polysaccharides	149-155	immunoglobulin heavy constant alpha 1	Homo sapiens	54-58
22192629-0	2012	Highly conserved HIV-1 gp120 glycans proximal to CD4-binding region affect viral infectivity and neutralizing antibody induction.	Polysaccharides	29-36	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	23-28
22170069-10	2012	The affinity of BambL for small fucosylated glycans is very high as demonstrated by microcalorimetry (K(D) &lt; 1 muM).	Polysaccharides	44-51	latexin	Homo sapiens	114-117
22158871-1	2012	Polysialic acid (polySia) is a unique polysaccharide that modifies neural cell adhesion molecule (NCAM) spatiotemporally.	Polysaccharides	38-52	neural cell adhesion molecule 1	Mus musculus	67-96
22227190-7	2012	Using glycan arrays, immobilized glycoprotein pulldowns, and glycan competition assays we demonstrate that FBXO2 preferentially binds unfolded glycoproteins.	Polysaccharides	6-12	F-box protein 2	Homo sapiens	107-112
22158871-1	2012	Polysialic acid (polySia) is a unique polysaccharide that modifies neural cell adhesion molecule (NCAM) spatiotemporally.	Polysaccharides	38-52	neural cell adhesion molecule 1	Mus musculus	98-102
22227190-7	2012	Using glycan arrays, immobilized glycoprotein pulldowns, and glycan competition assays we demonstrate that FBXO2 preferentially binds unfolded glycoproteins.	Polysaccharides	61-67	F-box protein 2	Homo sapiens	107-112
22200052-0	2012	Use of fungal derived polysaccharide-conjugated particles to probe Dectin-1 responses in innate immunity.	Polysaccharides	22-36	C-type lectin domain containing 7A	Homo sapiens	67-75
22034928-0	2012	Direct inhibition of the transforming growth factor-beta pathway by protein-bound polysaccharide through inactivation of Smad2 signaling.	Polysaccharides	82-96	transforming growth factor beta 1	Homo sapiens	25-56
22034928-0	2012	Direct inhibition of the transforming growth factor-beta pathway by protein-bound polysaccharide through inactivation of Smad2 signaling.	Polysaccharides	82-96	SMAD family member 2	Homo sapiens	121-126
22034928-3	2012	We recently screened for novel TGF-beta inhibitors among commercially available drugs and identified protein-bound polysaccharide (PSK) as a strong inhibitor of the TGF-beta-induced reporter activity of 3TP-lux, a TGF-beta1-responsive luciferase reporter.	Polysaccharides	115-129	transforming growth factor beta 1	Homo sapiens	31-39
22034928-3	2012	We recently screened for novel TGF-beta inhibitors among commercially available drugs and identified protein-bound polysaccharide (PSK) as a strong inhibitor of the TGF-beta-induced reporter activity of 3TP-lux, a TGF-beta1-responsive luciferase reporter.	Polysaccharides	115-129	TAO kinase 2	Homo sapiens	131-134
22034928-3	2012	We recently screened for novel TGF-beta inhibitors among commercially available drugs and identified protein-bound polysaccharide (PSK) as a strong inhibitor of the TGF-beta-induced reporter activity of 3TP-lux, a TGF-beta1-responsive luciferase reporter.	Polysaccharides	115-129	transforming growth factor beta 1	Homo sapiens	165-173
22034928-3	2012	We recently screened for novel TGF-beta inhibitors among commercially available drugs and identified protein-bound polysaccharide (PSK) as a strong inhibitor of the TGF-beta-induced reporter activity of 3TP-lux, a TGF-beta1-responsive luciferase reporter.	Polysaccharides	115-129	transforming growth factor beta 1	Homo sapiens	214-223
22123080-4	2012	In the current study, a detailed characterization of the recombinant human CD82 N-linked glycosylation pattern was conducted by employing an integrative proteomic and glycomic approach, including glycosidase and protease digestions, glycan permethylation, MS analyses, site-directed mutagenesis, and lectin blots.	Polysaccharides	233-239	CD82 molecule	Homo sapiens	75-79
22395466-5	2012	Several statistically significant associations were observed between HNF1A methylation and plasma glycans, while there were no significant associations with IgG glycans.	Polysaccharides	98-105	HNF1 homeobox A	Homo sapiens	69-74
22395466-6	2012	The most consistent association with HNF1A methylation was observed with the increase in the proportion of highly branched glycans in the plasma N-glycome.	Polysaccharides	123-130	HNF1 homeobox A	Homo sapiens	37-42
22395466-7	2012	The hypothesis that inactivation of HNF1A promotes branching of glycans was supported by the analysis of plasma N-glycomes in 61 patients with inactivating mutations in HNF1A, where the increase in plasma glycan branching was also observed.	Polysaccharides	64-71	HNF1 homeobox A	Homo sapiens	36-41
22395466-7	2012	The hypothesis that inactivation of HNF1A promotes branching of glycans was supported by the analysis of plasma N-glycomes in 61 patients with inactivating mutations in HNF1A, where the increase in plasma glycan branching was also observed.	Polysaccharides	64-71	HNF1 homeobox A	Homo sapiens	169-174
22395466-7	2012	The hypothesis that inactivation of HNF1A promotes branching of glycans was supported by the analysis of plasma N-glycomes in 61 patients with inactivating mutations in HNF1A, where the increase in plasma glycan branching was also observed.	Polysaccharides	64-70	HNF1 homeobox A	Homo sapiens	36-41
22395466-7	2012	The hypothesis that inactivation of HNF1A promotes branching of glycans was supported by the analysis of plasma N-glycomes in 61 patients with inactivating mutations in HNF1A, where the increase in plasma glycan branching was also observed.	Polysaccharides	64-70	HNF1 homeobox A	Homo sapiens	169-174
21880669-5	2012	KL-6/MUC1 contained core 1 and extended core 1 glycans modified with one or two sialic acid/sulfate residues.	Polysaccharides	47-54	mucin 1, cell surface associated	Homo sapiens	0-4
21880669-5	2012	KL-6/MUC1 contained core 1 and extended core 1 glycans modified with one or two sialic acid/sulfate residues.	Polysaccharides	47-54	mucin 1, cell surface associated	Homo sapiens	5-9
21880669-6	2012	Based on these structures, several synthetic glycans binding to anti-KL-6/mAb were compared with one another by surface plasmon resonance.	Polysaccharides	45-52	mucin 1, cell surface associated	Homo sapiens	69-77
21890892-1	2012	Polysialic acid (polySia) is mainly described as a glycan modification of the neural cell adhesion molecule NCAM1.	Polysaccharides	51-57	neural cell adhesion molecule 1a	Danio rerio	108-113
21893569-1	2012	Human zymogen granule protein 16 (ZG16p) contains a Jacalin-like lectin domain, although its glycan-binding properties are not fully understood.	Polysaccharides	93-99	zymogen granule protein 16	Homo sapiens	6-32
21893569-1	2012	Human zymogen granule protein 16 (ZG16p) contains a Jacalin-like lectin domain, although its glycan-binding properties are not fully understood.	Polysaccharides	93-99	zymogen granule protein 16	Homo sapiens	34-39
21893569-2	2012	Here, we screened the glycan-binding specificity of ZG16p by recently developed glycoconjugate microarray.	Polysaccharides	22-28	zymogen granule protein 16	Homo sapiens	52-57
21756025-0	2012	Targeting B lymphoma with nanoparticles bearing glycan ligands of CD22.	Polysaccharides	48-54	CD22 molecule	Homo sapiens	66-70
21756025-4	2012	As an alternative to antibodies we have developed liposomal nanoparticles decorated with glycan ligands of CD22 that selectively target B cells.	Polysaccharides	89-95	CD22 molecule	Homo sapiens	107-111
22170046-6	2012	The major glycoform of CASQ (GlcNAc(2)Man(9)) found in the proximal endoplasmic reticulum can severely hinder formation of the back-to-back interface, potentially preventing premature Ca(2+)-dependent polymerization of CASQ and ensuring its continuous mobility to the SR. Only trimmed glycans can stabilize both front-to-front and the back-to-back interfaces of CASQ through extensive hydrogen bonding and electrostatic interactions.	Polysaccharides	285-292	calsequestrin 1	Homo sapiens	23-27
22170046-6	2012	The major glycoform of CASQ (GlcNAc(2)Man(9)) found in the proximal endoplasmic reticulum can severely hinder formation of the back-to-back interface, potentially preventing premature Ca(2+)-dependent polymerization of CASQ and ensuring its continuous mobility to the SR. Only trimmed glycans can stabilize both front-to-front and the back-to-back interfaces of CASQ through extensive hydrogen bonding and electrostatic interactions.	Polysaccharides	285-292	calsequestrin 1	Homo sapiens	219-223
22170046-6	2012	The major glycoform of CASQ (GlcNAc(2)Man(9)) found in the proximal endoplasmic reticulum can severely hinder formation of the back-to-back interface, potentially preventing premature Ca(2+)-dependent polymerization of CASQ and ensuring its continuous mobility to the SR. Only trimmed glycans can stabilize both front-to-front and the back-to-back interfaces of CASQ through extensive hydrogen bonding and electrostatic interactions.	Polysaccharides	285-292	calsequestrin 1	Homo sapiens	219-223
22101717-4	2012	Lectin-like receptors CD206 (macrophage mannose receptor) and SIGNR1 were previously shown to mediate uptake of bacterial polysaccharides.	Polysaccharides	122-137	mannose receptor C-type 1	Homo sapiens	22-27
22142583-3	2012	We are exploring a strategy whereby extra glycans are incorporated onto gp120 to occlude the epitopes of non-neutralizing mAbs while maintaining exposure of the b12 site.	Polysaccharides	42-49	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	72-77
22246324-4	2012	Galectin 8 monitors endosomal and lysosomal integrity and detects bacterial invasion by binding host glycans exposed on damaged Salmonella-containing vacuoles.	Polysaccharides	101-108	galectin 8	Homo sapiens	0-10
22973103-1	2012	The aim of this study was to develop a temperature-induced polyethylene glycol (PEG) water phase/polysaccharide water-phase emulsion approach for preparing interferon alpha-2b (IFNalpha-2b)-loaded polysaccharide nanoparticles.	Polysaccharides	97-111	interferon alpha 2	Homo sapiens	156-175
22848211-2	2012	As polysaccharides exhibit structure-dependent biological functions in the present study water-soluble polysaccharides were extracted from herb material, fractionated by anion exchange chromatography into four main polysaccharide fractions (denominated as Hp1, Hp2, Hp3 and Hp4) and characterized by HPAEC-PAD, CE, IR and GC-MS.	Polysaccharides	3-18	defensin alpha 1	Homo sapiens	256-259
22848211-2	2012	As polysaccharides exhibit structure-dependent biological functions in the present study water-soluble polysaccharides were extracted from herb material, fractionated by anion exchange chromatography into four main polysaccharide fractions (denominated as Hp1, Hp2, Hp3 and Hp4) and characterized by HPAEC-PAD, CE, IR and GC-MS.	Polysaccharides	3-18	defensin alpha 3	Homo sapiens	266-269
22848211-2	2012	As polysaccharides exhibit structure-dependent biological functions in the present study water-soluble polysaccharides were extracted from herb material, fractionated by anion exchange chromatography into four main polysaccharide fractions (denominated as Hp1, Hp2, Hp3 and Hp4) and characterized by HPAEC-PAD, CE, IR and GC-MS.	Polysaccharides	3-18	defensin alpha 4	Homo sapiens	274-277
22848211-5	2012	Polysaccharide fraction Hp1 was mainly composed of beta-D-glucose.	Polysaccharides	0-14	defensin alpha 1	Homo sapiens	24-27
22848211-7	2012	Polysaccharides of Hp1 induced the keratinocyte differentiation by inhibiting the gene expression of the epidermal growth factor and insulin receptor.	Polysaccharides	0-15	defensin alpha 1	Homo sapiens	19-22
22799339-1	2012	AIM: To investigate the protective effect of purified fraction 1 polysaccharide extracted from Rheum tanguticum RTP1 on irradiation-induced immune damage in mice.	Polysaccharides	65-79	receptor transporter protein 1	Mus musculus	112-116
22466566-2	2012	We previously reported that NCR1 (NKp46) can bind to multimeric NeuNAc-containing N-glycans and sulfated glycans.	Polysaccharides	84-91	natural cytotoxicity triggering receptor 1	Homo sapiens	28-32
22466566-2	2012	We previously reported that NCR1 (NKp46) can bind to multimeric NeuNAc-containing N-glycans and sulfated glycans.	Polysaccharides	84-91	natural cytotoxicity triggering receptor 1	Homo sapiens	34-39
22466566-3	2012	In this study, we investigated whether NKp44 and NKp30 can bind to NeuNAc-containing glycans using their common recombinant extracellular domain tagged with 6xHis (NKp44-H6 and NKp30-H6).	Polysaccharides	85-92	natural cytotoxicity triggering receptor 2	Homo sapiens	39-44
22466566-3	2012	In this study, we investigated whether NKp44 and NKp30 can bind to NeuNAc-containing glycans using their common recombinant extracellular domain tagged with 6xHis (NKp44-H6 and NKp30-H6).	Polysaccharides	85-92	natural cytotoxicity triggering receptor 3	Homo sapiens	49-54
22873100-2	2012	Since glycan modifications of MUC1 are potentially relevant for physiological as well as pathological processes, this study was aimed at establishing an expression profile of two MUC1 glycoepitopes, CA 15-3 and CA 19-9, in trophoblast throughout pregnancy.	Polysaccharides	6-12	mucin 1, cell surface associated	Homo sapiens	30-34
22873100-2	2012	Since glycan modifications of MUC1 are potentially relevant for physiological as well as pathological processes, this study was aimed at establishing an expression profile of two MUC1 glycoepitopes, CA 15-3 and CA 19-9, in trophoblast throughout pregnancy.	Polysaccharides	6-12	mucin 1, cell surface associated	Homo sapiens	179-183
22536281-5	2012	The polysaccharides also significantly enhanced the antioxidant enzyme activities (superoxide dismutase, catalase, and glutathione peroxidase) and markedly decreased the malondialdehyde production of lipid peroxidation in a D-galactose-induced aging mouse model.	Polysaccharides	4-19	catalase	Mus musculus	105-113
22187327-9	2012	Taken together, the Asn(54)-linked glycan is necessary for normal trafficking and function of ICAM-5, but is unassociated with ER-associated degradation of it.	Polysaccharides	35-41	intercellular adhesion molecule 5, telencephalin	Mus musculus	94-100
22949880-4	2012	The need for independent identification of CA125 is exemplified by several reports where mutually exclusive data concerning the existence of isoforms and the glycan moieties is presented.	Polysaccharides	158-164	mucin 16, cell surface associated	Homo sapiens	43-48
22838182-8	2012	Glycan analysis of serum transferrin (by isoelectric focusing or more sophisticated methods, such as HPLC (high-performance liquid chromatography) or MALDI (matrix-assisted laser desorption/ionization)) or serum N-glycans (by MS), enzyme activity assays and DNA sequence analysis are the most frequently used methods for CDG screening and identification, since no specific tests are available yet.	Polysaccharides	0-6	transferrin	Homo sapiens	25-36
22975511-0	2012	Hepatoprotective effects of the polysaccharide isolated from Tarphochlamys affinis (Acanthaceae) against CCl4-induced hepatic injury.	Polysaccharides	32-46	C-C motif chemokine ligand 4	Rattus norvegicus	105-109
22975511-1	2012	This study was designed to investigate the protective effects of the polysaccharide isolated from Tarphochlamys affinis (PTA) against CCl4-induced hepatotoxicity in rats.	Polysaccharides	69-83	C-C motif chemokine ligand 4	Rattus norvegicus	134-138
22264046-2	2012	Here, we discuss the combination of tenofovir with various other antiretrovirals (ARV) highlighting the large class of carbohydrate-binding agents (CBAs) targeting the glycans on the viral envelope gp120 for their anti-HIV activity and their favorable combinatory potential.	Polysaccharides	168-175	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	198-203
21956693-1	2012	CD22 (Siglec-2) is a B-cell membrane-bound lectin that recognizes glycan ligands containing alpha2,6-linked sialic acid (alpha2,6Sia) and negatively regulates signaling through the B-cell Ag receptor (BCR).	Polysaccharides	66-72	CD22 molecule	Homo sapiens	0-4
21956693-1	2012	CD22 (Siglec-2) is a B-cell membrane-bound lectin that recognizes glycan ligands containing alpha2,6-linked sialic acid (alpha2,6Sia) and negatively regulates signaling through the B-cell Ag receptor (BCR).	Polysaccharides	66-72	CD22 molecule	Homo sapiens	6-14
21956693-3	2012	Here, we demonstrate that CD22 is efficiently activated in trans by complexes of Ag and soluble IgM (sIgM) due to the presence of glycan ligands on sIgM.	Polysaccharides	130-136	CD22 molecule	Homo sapiens	26-30
22201835-1	2012	CD44 and RHAMM are two extracellar matrix receptors whose principle ligand is the polysaccharide hyaluronan (HA).	Polysaccharides	82-96	CD44 molecule (Indian blood group)	Homo sapiens	0-4
22201835-1	2012	CD44 and RHAMM are two extracellar matrix receptors whose principle ligand is the polysaccharide hyaluronan (HA).	Polysaccharides	82-96	hyaluronan mediated motility receptor	Homo sapiens	9-14
22837686-6	2012	The results showed that the rats which were fed pu-erh tea or polysaccharides had lower levels of NO which corresponded with the down-regulation of inducible nitric oxide synthase (iNOS) expression.	Polysaccharides	62-77	nitric oxide synthase 2	Rattus norvegicus	148-179
22837686-6	2012	The results showed that the rats which were fed pu-erh tea or polysaccharides had lower levels of NO which corresponded with the down-regulation of inducible nitric oxide synthase (iNOS) expression.	Polysaccharides	62-77	nitric oxide synthase 2	Rattus norvegicus	181-185
22837686-8	2012	Thus we find that the polysaccharide components in pu-erh tea reduce NO levels in an animal model by inhibiting the iNOS expression via signaling through TLR4.	Polysaccharides	22-36	nitric oxide synthase 2	Rattus norvegicus	116-120
22837686-8	2012	Thus we find that the polysaccharide components in pu-erh tea reduce NO levels in an animal model by inhibiting the iNOS expression via signaling through TLR4.	Polysaccharides	22-36	toll-like receptor 4	Rattus norvegicus	154-158
22214633-1	2012	We report a case of elderly-onset neuromyelitis optica (NMO) positive for the anti-aquaporin-4 (AQP-4) antibody; symptoms developed after the diagnosis of prostate adenocarcinoma and relapsed after a 23-valent pneumococcal polysaccharide vaccination.	Polysaccharides	223-237	aquaporin 4	Homo sapiens	83-94
22214633-1	2012	We report a case of elderly-onset neuromyelitis optica (NMO) positive for the anti-aquaporin-4 (AQP-4) antibody; symptoms developed after the diagnosis of prostate adenocarcinoma and relapsed after a 23-valent pneumococcal polysaccharide vaccination.	Polysaccharides	223-237	aquaporin 4	Homo sapiens	96-101
22973103-1	2012	The aim of this study was to develop a temperature-induced polyethylene glycol (PEG) water phase/polysaccharide water-phase emulsion approach for preparing interferon alpha-2b (IFNalpha-2b)-loaded polysaccharide nanoparticles.	Polysaccharides	197-211	interferon alpha 2	Homo sapiens	156-175
22217303-5	2012	Using size-exclusion chromatography to fractionate the crude extract of A. bisporus, two polysaccharide fractions (designated as ABP-1 and ABP-2) were obtained.	Polysaccharides	89-103	amine oxidase, copper-containing 1	Mus musculus	129-134
22259131-1	2012	The characterization of mucin-type O-glycosylation is fraught with extreme difficulty at almost every level of analysis: from difficulties in obtaining glycopeptides suitable for study, their structural heterogeneity, lack of broad acting glycosidase tools capable of simplifying the glycans, and finally the vast complexity of performing analysis on multiply glycosylated glycopeptides.	Polysaccharides	284-291	LOC100508689	Homo sapiens	24-29
22077268-1	2012	A native polysaccharide (MCP2) was extracted and isolated from Momordica charantia.	Polysaccharides	9-23	C-C motif chemokine ligand 8	Homo sapiens	25-29
23144627-0	2012	A targeted glycan-related gene screen reveals heparan sulfate proteoglycan sulfation regulates WNT and BMP trans-synaptic signaling.	Polysaccharides	11-17	Wnt oncogene analog 2	Drosophila melanogaster	95-98
23144627-0	2012	A targeted glycan-related gene screen reveals heparan sulfate proteoglycan sulfation regulates WNT and BMP trans-synaptic signaling.	Polysaccharides	11-17	glass bottom boat	Drosophila melanogaster	103-106
23272204-2	2012	Haptoglobin (Hpt), a glycoprotein secreted by hepatocytes and other types of cells including keratinocytes, was found with glycan changes in psoriasis and other diseases.	Polysaccharides	123-129	haptoglobin	Homo sapiens	0-11
23272204-2	2012	Haptoglobin (Hpt), a glycoprotein secreted by hepatocytes and other types of cells including keratinocytes, was found with glycan changes in psoriasis and other diseases.	Polysaccharides	123-129	haptoglobin	Homo sapiens	13-16
23272204-9	2012	High levels of glycans with fucosylated and tetra-antennary chains were detected on the peptide NLFLNHSENATAK from Hpt of psoriatic patients.	Polysaccharides	15-22	haptoglobin	Homo sapiens	115-118
23272204-10	2012	Our data demonstrate that specific changes in glycan structures of Hpt, such as enhanced glycan branching and fucose content, are associated with psoriasis, and that differences between circulating and skin Hpt do exist.	Polysaccharides	46-52	haptoglobin	Homo sapiens	67-70
23272204-7	2012	Hpt from skin and plasma of patients showed more fucosylated and branched glycans than Hpt from plasma of healthy subjects.	Polysaccharides	74-81	haptoglobin	Homo sapiens	0-3
23272204-10	2012	Our data demonstrate that specific changes in glycan structures of Hpt, such as enhanced glycan branching and fucose content, are associated with psoriasis, and that differences between circulating and skin Hpt do exist.	Polysaccharides	89-95	haptoglobin	Homo sapiens	67-70
23272204-11	2012	A lower extent of glycan fucosylation and branching was found in Hpt from plasma of patients in disease remission.	Polysaccharides	18-24	haptoglobin	Homo sapiens	65-68
23272204-8	2012	Tryptic glycopeptides of Hpt were also analyzed by mass spectrometry, and a decreased amount of sialylated glycan chains was found in glycopeptides of skin Hpt, as compared with Hpt from plasma.	Polysaccharides	107-113	haptoglobin	Homo sapiens	156-159
23272204-8	2012	Tryptic glycopeptides of Hpt were also analyzed by mass spectrometry, and a decreased amount of sialylated glycan chains was found in glycopeptides of skin Hpt, as compared with Hpt from plasma.	Polysaccharides	107-113	haptoglobin	Homo sapiens	156-159
22860112-1	2012	Equine type 1 polysaccharide storage myopathy (PSSM1), a common glycogenosis associated with an R309H founder mutation in the glycogen synthase 1 gene (GYS1), shares pathological features with several human myopathies.	Polysaccharides	14-28	glycogen synthase 1	Homo sapiens	126-145
23049681-0	2012	The critical role of Astragalus polysaccharides for the improvement of PPARalpha [ correction of PPRAalpha]-mediated lipotoxicity in diabetic cardiomyopathy.	Polysaccharides	32-47	peroxisome proliferator activated receptor alpha	Mus musculus	71-80
23029318-3	2012	Glycan array screening of the recombinant lectin, termed PFL, has revealed that PFL preferentially recognizes high mannose glycans with alpha1-3 Man that was highly exposed at the D2 position.	Polysaccharides	0-6	profilin 2	Homo sapiens	57-60
23029318-3	2012	Glycan array screening of the recombinant lectin, termed PFL, has revealed that PFL preferentially recognizes high mannose glycans with alpha1-3 Man that was highly exposed at the D2 position.	Polysaccharides	0-6	profilin 2	Homo sapiens	80-83
22860112-1	2012	Equine type 1 polysaccharide storage myopathy (PSSM1), a common glycogenosis associated with an R309H founder mutation in the glycogen synthase 1 gene (GYS1), shares pathological features with several human myopathies.	Polysaccharides	14-28	glycogen synthase 1	Homo sapiens	152-156
22723922-3	2012	Here we describe a novel approach for delivering antigens to macrophages using liposomal nanoparticles displaying high affinity glycan ligands of Sn.	Polysaccharides	128-134	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	146-148
23002422-1	2012	Model organisms containing deletion or mutation in a glycosyltransferase-gene exhibit various physiological abnormalities, suggesting that specific glycan motifs on certain proteins play important roles in vivo.	Polysaccharides	148-154	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	53-72
22666317-7	2012	This glycan increases the affinity of IgG to CD16 on effector cells, consequently enhancing Antibody-Dependent Cellular Cytotoxicity (ADCC).	Polysaccharides	5-11	Fc gamma receptor IIIa	Homo sapiens	45-49
22348006-4	2012	METHODOLOGY: We used isothermal titration calorimetry (ITC) and enzyme-linked immunosorbent assay (ELISA) to examine binding of Stx1 and Stx2 to various glycans, glycosphingolipids, and glycosphingolipid mixtures in the presence or absence of membrane components, phosphatidylcholine, and cholesterol.	Polysaccharides	153-160	syntaxin-2	Chlorocebus sabaeus	137-141
22253810-7	2012	Glycan analysis using several lectins revealed glomerular epithelial cell hyposialylation, particularly the hyposialylation of podocalyxin, which is one of important molecules for the glomerular filtration barrier.	Polysaccharides	0-6	podocalyxin-like	Mus musculus	127-138
22768188-8	2012	Disruption of the ALG3 gene resulted in modification of proteins mainly with Man(5)GlcNAc(2) and GlcMan(5)GlcNAc(2) glycans, and to a lesser extent with Glc(2)Man(5)GlcNAc(2) glycans.	Polysaccharides	116-123	ALG3 alpha-1,3- mannosyltransferase	Homo sapiens	18-22
22768188-8	2012	Disruption of the ALG3 gene resulted in modification of proteins mainly with Man(5)GlcNAc(2) and GlcMan(5)GlcNAc(2) glycans, and to a lesser extent with Glc(2)Man(5)GlcNAc(2) glycans.	Polysaccharides	175-182	ALG3 alpha-1,3- mannosyltransferase	Homo sapiens	18-22
22768188-11	2012	Finally, we overexpressed an alpha-1,2-mannosidase to obtain Man(3)GlcNAc(2) structures, which are substrates for the synthesis of complex-type glycans.	Polysaccharides	144-151	mannosidase alpha class 1A member 2	Homo sapiens	29-50
22496731-7	2012	We hypothesized that removal of negatively charged sialyl residues from glycans on the TLR4 complex would hasten the dimerization of TLR4 monomers required for signaling.	Polysaccharides	72-79	toll like receptor 4	Homo sapiens	87-91
22496731-7	2012	We hypothesized that removal of negatively charged sialyl residues from glycans on the TLR4 complex would hasten the dimerization of TLR4 monomers required for signaling.	Polysaccharides	72-79	toll like receptor 4	Homo sapiens	133-137
23236285-5	2012	We have identified the oligosaccharide portion of ganglioside GM2 (the GM2 glycan) as a receptor for the attachment protein sigma1 of reovirus strain type 1 Lang (T1L) using glycan array screening.	Polysaccharides	75-81	cytochrome b5 domain containing 2	Mus musculus	62-65
23236285-5	2012	We have identified the oligosaccharide portion of ganglioside GM2 (the GM2 glycan) as a receptor for the attachment protein sigma1 of reovirus strain type 1 Lang (T1L) using glycan array screening.	Polysaccharides	75-81	cytochrome b5 domain containing 2	Mus musculus	71-74
23002422-2	2012	Identification of the target proteins of glycosyltransferase isozymes is the key to understand the roles of glycans.	Polysaccharides	108-115	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	41-60
22687727-2	2012	Our recent study showed that beta-1,4-GalT V-knockout mice are embryonic lethal, suggesting the importance of the glycans synthesized by beta-1,4-GalT V for embryonic development.	Polysaccharides	114-121	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	Mus musculus	29-42
22006924-0	2011	The highly conserved glycan at asparagine 260 of HIV-1 gp120 is indispensable for viral entry.	Polysaccharides	21-27	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	55-60
22056482-9	2011	Together, these results show selectivity in lectin binding to gp91phox, and provide evidence for the biochemical structures of the gp91phox glycans.	Polysaccharides	140-147	cytochrome b-245 beta chain	Homo sapiens	131-139
22006924-8	2011	Thus, the Asn-260 glycan in the gp120 envelope of HIV-1 represents a hot spot for targeting suicidal drugs or antibodies in a therapeutic effort to efficiently neutralize a broad array of virus strains.	Polysaccharides	18-24	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	32-37
21908519-3	2011	Using a recently developed high-throughput high-performance liquid chromatography (HPLC) analysis method, we have reported, in a pilot genome-wide association study of 13 glycan features in 2705 individuals from three European populations, that polymorphisms at three loci (FUT8, FUT6/FUT3 and HNF1A) affect plasma levels of N-glycans.	Polysaccharides	171-177	fucosyltransferase 8	Homo sapiens	274-278
21908519-3	2011	Using a recently developed high-throughput high-performance liquid chromatography (HPLC) analysis method, we have reported, in a pilot genome-wide association study of 13 glycan features in 2705 individuals from three European populations, that polymorphisms at three loci (FUT8, FUT6/FUT3 and HNF1A) affect plasma levels of N-glycans.	Polysaccharides	171-177	fucosyltransferase 6	Homo sapiens	280-284
21908519-3	2011	Using a recently developed high-throughput high-performance liquid chromatography (HPLC) analysis method, we have reported, in a pilot genome-wide association study of 13 glycan features in 2705 individuals from three European populations, that polymorphisms at three loci (FUT8, FUT6/FUT3 and HNF1A) affect plasma levels of N-glycans.	Polysaccharides	171-177	fucosyltransferase 3 (Lewis blood group)	Homo sapiens	285-289
21908519-3	2011	Using a recently developed high-throughput high-performance liquid chromatography (HPLC) analysis method, we have reported, in a pilot genome-wide association study of 13 glycan features in 2705 individuals from three European populations, that polymorphisms at three loci (FUT8, FUT6/FUT3 and HNF1A) affect plasma levels of N-glycans.	Polysaccharides	171-177	HNF1 homeobox A	Homo sapiens	294-299
21908519-5	2011	MGAT5 (meta-analysis association P-value = 1.80 x 10(-10) for rs1257220) encodes a glycosyltransferase which is known to synthesize the associated glycans.	Polysaccharides	147-154	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	0-5
22687727-2	2012	Our recent study showed that beta-1,4-GalT V-knockout mice are embryonic lethal, suggesting the importance of the glycans synthesized by beta-1,4-GalT V for embryonic development.	Polysaccharides	114-121	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	Mus musculus	137-150
22687729-7	2012	We clarified that all of these rKLRs can bind to high sLeX-expressing glycoprotein and heparin, heparan sulfate and highly sulfated polysaccharides and that glycan binding sites on NKG2D are mostly overlapped with those of protein ligands.	Polysaccharides	157-163	killer cell lectin like receptor K1	Homo sapiens	181-186
22167226-1	2011	Mannose-binding lectin (MBL) is a key soluble pathogen recognition protein of the innate immune system that binds specific mannose-containing glycans on the surfaces of microbial agents and initiates complement activation via the lectin pathway.	Polysaccharides	142-149	mannose binding lectin 2	Homo sapiens	24-27
22123961-0	2011	Rapid development of glycan-specific, broad, and potent anti-HIV-1 gp120 neutralizing antibodies in an R5 SIV/HIV chimeric virus infected macaque.	Polysaccharides	21-27	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	67-72
22135470-9	2011	This study provides conclusive evidence that the GAUT1:GAUT7 complex is the catalytic core of an HG:GalAT complex and that cell wall matrix polysaccharide biosynthesis occurs via protein complexes.	Polysaccharides	140-154	galacturonosyltransferase 1	Arabidopsis thaliana	49-54
22135470-9	2011	This study provides conclusive evidence that the GAUT1:GAUT7 complex is the catalytic core of an HG:GalAT complex and that cell wall matrix polysaccharide biosynthesis occurs via protein complexes.	Polysaccharides	140-154	galacturonosyltransferase 7	Arabidopsis thaliana	55-60
21978830-3	2011	Fucosyltransferases are enzymes that add fucose to precursor glycan structures: FUT3 and FUT5 catalyze the addition of fucose to the alpha1-3,4 position and are detected in epithelial cells.	Polysaccharides	61-67	fucosyltransferase 3 (Lewis blood group)	Homo sapiens	80-84
22152306-6	2011	In addition, neuraminidase treatment of apoC-III which removes the sialic acids from its glycan chain decreases its potential to inhibit LPL.	Polysaccharides	89-95	neuraminidase 1	Homo sapiens	13-26
22152306-6	2011	In addition, neuraminidase treatment of apoC-III which removes the sialic acids from its glycan chain decreases its potential to inhibit LPL.	Polysaccharides	89-95	apolipoprotein C3	Homo sapiens	40-48
22152306-6	2011	In addition, neuraminidase treatment of apoC-III which removes the sialic acids from its glycan chain decreases its potential to inhibit LPL.	Polysaccharides	89-95	lipoprotein lipase	Homo sapiens	137-140
21978830-3	2011	Fucosyltransferases are enzymes that add fucose to precursor glycan structures: FUT3 and FUT5 catalyze the addition of fucose to the alpha1-3,4 position and are detected in epithelial cells.	Polysaccharides	61-67	fucosyltransferase 5	Homo sapiens	89-93
21651437-1	2011	With the exception of polysaccharides and triterpenes/triterpenoids compounds, fungal immunomodulatory protein (FIP), a small molecule protein, is also an important bioactive component with immune regulating activity.	Polysaccharides	22-37	upstream transcription factor 2, c-fos interacting	Homo sapiens	112-115
21934490-5	2011	Acidic polysaccharide in the pollen that adsorbed to the diethylaminoethyl (DEAE) column was the causative agent of factor XII activation.	Polysaccharides	7-21	coagulation factor XII (Hageman factor)	Mus musculus	116-126
21711243-5	2011	Here, we investigated the interaction of a protein with a polysaccharide nanogel using fluorescence correlation spectroscopy at variable temperatures, using fluorescence-labeled bovine serum albumin (BSA) as a model protein.	Polysaccharides	58-72	albumin	Homo sapiens	185-198
22102160-9	2011	Neuraminidase was used to determine total glycan content of the low-abundance glycans containing sialic acid.	Polysaccharides	42-48	neuraminidase 1	Homo sapiens	0-13
22102160-9	2011	Neuraminidase was used to determine total glycan content of the low-abundance glycans containing sialic acid.	Polysaccharides	78-85	neuraminidase 1	Homo sapiens	0-13
22180206-1	2011	Site-specific characterisation of mucin-type O-linked glycosylation is an analytical challenge due to glycan heterogeneity, lack of glycosylation site consensus sequence and high density of occupied glycosylation sites.	Polysaccharides	102-108	LOC100508689	Homo sapiens	34-39
22009724-2	2011	Heparanase, an endoglycosidase capable of degrading heparan sulfate, a major polysaccharide constituent of the ECM, is implicated in diverse processes associated with ECM remodeling, such as morphogenesis, angiogenesis, and tumor invasion.	Polysaccharides	77-91	heparanase	Rattus norvegicus	0-10
21421995-4	2011	MALDI-TOF analysis of total N-linked glycoconjugates indicated a decrease in the relative amount of sialylated glycans in both COG3 KD and COG4 KD cells.	Polysaccharides	111-118	component of oligomeric golgi complex 3	Homo sapiens	127-131
21840970-3	2011	Recent studies have confirmed that P. pastoris has four genes from the beta-mannosyl transferase (BMT) family and that Bmt2p is responsible for the majority of beta-Man linkages on glycans.	Polysaccharides	181-188	base methyltransferase of 25S rRNA 2 homolog	Homo sapiens	119-124
21840970-6	2011	Thorough analysis of the glycan profile of rhEPO demonstrated the presence of low amounts of alpha-1,2-mannosidase resistant high-Man glycoforms.	Polysaccharides	25-31	mannosidase alpha class 1A member 2	Homo sapiens	93-114
22093069-4	2011	EF2863 hydrolyzes the glycosidic bond between two N-acetylglucosamines (GlcNAc) in N-linked glycans of the high-mannose and hybrid type, releasing the glycan and leaving one GlcNAc attached to the protein.	Polysaccharides	92-98	chitinase	Enterococcus faecalis V583	0-6
21421995-4	2011	MALDI-TOF analysis of total N-linked glycoconjugates indicated a decrease in the relative amount of sialylated glycans in both COG3 KD and COG4 KD cells.	Polysaccharides	111-118	component of oligomeric golgi complex 4	Homo sapiens	139-143
21740504-7	2011	Glycan analysis revealed that LTB-MUC1 was glycosylated and a MUC1-specific monoclonal antibody detected only the glycosylated forms.	Polysaccharides	0-6	lymphotoxin beta	Homo sapiens	30-33
21948103-4	2011	The ABO blood group glycan antigens were selected as well recognized ligands for sensitivity and specificity assessments.	Polysaccharides	20-26	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	4-7
21198966-9	2011	Polysaccharide storage myopathy horses had significantly higher glycaemic and insulinaemic responses to HC vs. LC, however; the magnitude of insulin response was lower and glucose response higher in PSSM vs. control horses.	Polysaccharides	0-14	INS	Equus caballus	78-85
21720768-1	2011	The expressions of beta1,3-N-acetylglucosamonyltransferase-2 and -8 (beta3GnT-2, beta3GnT-8),-the two main glycosyltransferases responsible for the synthesis of poly-N-acetyllactosamine (polyLacNAc) in glycans, and beta3GnT-5 participating in the syntheses of sphingoglycolipids were studied in leukemia cell lines during differentiation using RT-PCR method.	Polysaccharides	202-209	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	19-26
21720768-1	2011	The expressions of beta1,3-N-acetylglucosamonyltransferase-2 and -8 (beta3GnT-2, beta3GnT-8),-the two main glycosyltransferases responsible for the synthesis of poly-N-acetyllactosamine (polyLacNAc) in glycans, and beta3GnT-5 participating in the syntheses of sphingoglycolipids were studied in leukemia cell lines during differentiation using RT-PCR method.	Polysaccharides	202-209	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	69-79
21720768-1	2011	The expressions of beta1,3-N-acetylglucosamonyltransferase-2 and -8 (beta3GnT-2, beta3GnT-8),-the two main glycosyltransferases responsible for the synthesis of poly-N-acetyllactosamine (polyLacNAc) in glycans, and beta3GnT-5 participating in the syntheses of sphingoglycolipids were studied in leukemia cell lines during differentiation using RT-PCR method.	Polysaccharides	202-209	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	Homo sapiens	81-91
21720768-1	2011	The expressions of beta1,3-N-acetylglucosamonyltransferase-2 and -8 (beta3GnT-2, beta3GnT-8),-the two main glycosyltransferases responsible for the synthesis of poly-N-acetyllactosamine (polyLacNAc) in glycans, and beta3GnT-5 participating in the syntheses of sphingoglycolipids were studied in leukemia cell lines during differentiation using RT-PCR method.	Polysaccharides	202-209	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	Homo sapiens	215-225
21801300-5	2011	The inverted-repeat chimeric RNA silencing construct of alpha-1,3-fucosyltransferase and beta-1,2-xylosyltransferase (Delta3FT/XT)-9 glyco-engineered line with significantly reduced core alpha-1,3-fucosylated and/or beta-1,2-xylosylated glycan structures was established.	Polysaccharides	237-243	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	89-97
21740504-8	2011	A thorough saccharide analysis revealed that the glycans are tri-arabinans linked to hydroxyprolines within the MUC1 tandem repeat sequence.	Polysaccharides	49-56	mucin 1, cell surface associated	Homo sapiens	112-116
21965658-1	2011	The recognition of influenza A virus (IAV) by surfactant protein D (SP-D) is mediated by interactions between the SP-D carbohydrate recognition domains (CRD) and glycans displayed on envelope glycoproteins.	Polysaccharides	162-169	surfactant protein D	Homo sapiens	68-72
21831883-2	2011	Galectin-1 (gal-1), a member of the mammalian beta-galactoside-binding proteins, exerts biological effects by recognition of glycan ligands, including those involved in cell adhesion and growth regulation.	Polysaccharides	125-131	galectin 1	Homo sapiens	0-10
21831883-2	2011	Galectin-1 (gal-1), a member of the mammalian beta-galactoside-binding proteins, exerts biological effects by recognition of glycan ligands, including those involved in cell adhesion and growth regulation.	Polysaccharides	125-131	galectin 1	Homo sapiens	12-17
22525502-10	2011	OPN from metastasis HCC tissues presented lower level of some specific glycan structures such as a2, 3- sialic acid, bisecting GlcNAc, biantennary, muti-antennary and high mannose type N-glycan structure.	Polysaccharides	71-77	secreted phosphoprotein 1	Homo sapiens	0-3
21965658-9	2011	The combined data support a model in which altered binding by a truncated mutant SP-D to IAV HA glycans facilitates viral aggregation, leading to significant viral neutralization in vitro and in vivo.	Polysaccharides	96-103	surfactant protein D	Homo sapiens	81-85
21949056-1	2011	The aim of this study was to determine the occurrence and frequency of a mutation in the gene coding for skeletal muscle glycogen synthase type 1 (GYS-1), which is the cause of equine polysaccharide storage myopathy (PSSM) type 1 in a population of 50 Haflingers.	Polysaccharides	184-198	glycogen synthase 1	Equus caballus	147-152
21998254-1	2011	The HIV envelope (Env) protein gp120 is protected from antibody recognition by a dense glycan shield.	Polysaccharides	87-93	endogenous retrovirus group K member 20	Homo sapiens	18-21
22122911-8	2011	CONCLUSION: The HBMs of DBPs that bind to DARC have similar heparin binding affinities as some V3 loop peptides and chemokines, are responsible for specific sulfated polysaccharide inhibition of parasite binding and invasion of red blood cells, and are more likely to bind to negative charges on the receptor than cell surface glycosaminoglycans.	Polysaccharides	166-180	atypical chemokine receptor 1 (Duffy blood group)	Homo sapiens	42-46
21998254-1	2011	The HIV envelope (Env) protein gp120 is protected from antibody recognition by a dense glycan shield.	Polysaccharides	87-93	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	31-36
21998254-4	2011	Fab PGT 128 complexed with a fully glycosylated gp120 outer domain at 3.25 angstroms reveals that the antibody penetrates the glycan shield and recognizes two conserved glycans as well as a short beta-strand segment of the gp120 V3 loop, accounting for its high binding affinity and broad specificity.	Polysaccharides	126-132	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	48-53
21998254-4	2011	Fab PGT 128 complexed with a fully glycosylated gp120 outer domain at 3.25 angstroms reveals that the antibody penetrates the glycan shield and recognizes two conserved glycans as well as a short beta-strand segment of the gp120 V3 loop, accounting for its high binding affinity and broad specificity.	Polysaccharides	169-176	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	48-53
21978170-1	2011	This work investigated the role of structure in the binding of polysaccharides from 10 regionally different strains of Lentinula edodes to Toll-like receptor 4 (TLR-4) on monocytes (THP-1) and the potential effect of this interaction on tumor cell viability.	Polysaccharides	63-78	toll like receptor 4	Homo sapiens	139-159
21937430-1	2011	MUC1 is efficiently delivered to the apical surface of polarized Madin-Darby canine kidney (MDCK) cells by transit through apical recycling endosomes, a route associated with delivery of apical proteins with glycan-dependent targeting signals.	Polysaccharides	208-214	mucin 1, cell surface associated	Canis lupus familiaris	0-4
21978170-1	2011	This work investigated the role of structure in the binding of polysaccharides from 10 regionally different strains of Lentinula edodes to Toll-like receptor 4 (TLR-4) on monocytes (THP-1) and the potential effect of this interaction on tumor cell viability.	Polysaccharides	63-78	toll like receptor 4	Homo sapiens	161-166
21978170-1	2011	This work investigated the role of structure in the binding of polysaccharides from 10 regionally different strains of Lentinula edodes to Toll-like receptor 4 (TLR-4) on monocytes (THP-1) and the potential effect of this interaction on tumor cell viability.	Polysaccharides	63-78	GLI family zinc finger 2	Homo sapiens	182-187
22013110-9	2011	Our results uncover an unexpected heterogeneity in the glycosylation pattern of clusterin and suggest that the expression of high concentrations of fucose-containing glycans enables semen clusterin to display a unique set of biological functions that might affect the early course of sexually transmitted infectious diseases.	Polysaccharides	166-173	clusterin	Homo sapiens	188-197
21832933-5	2011	It is also known that gp120 glycans affect the binding and function of anti-gp120 antibodies.	Polysaccharides	28-35	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	22-27
21832933-5	2011	It is also known that gp120 glycans affect the binding and function of anti-gp120 antibodies.	Polysaccharides	28-35	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	76-81
21832933-13	2011	CONCLUSION: Vaccine-induced IgG2 may adversely affect a potentially important antiviral antibody activity, and altering Env glycans might provide the means to bias the subclass response in a favorable direction.	Polysaccharides	124-131	endogenous retrovirus group W member 1, envelope	Homo sapiens	120-123
21937430-2	2011	However, a role for glycans in MUC1 sorting has not been established.	Polysaccharides	20-27	mucin 1, cell surface associated	Canis lupus familiaris	31-35
21945958-0	2011	Improving immunogenicity of HIV-1 envelope gp120 by glycan removal and immune complex formation.	Polysaccharides	52-58	endogenous retrovirus group K member 20	Homo sapiens	34-42
21945958-10	2011	Similar results were achieved with a complex made with gp120 bearing an N448E mutation, confirming the importance of the N448-linked glycan in modulating gp120 immunogenicity.	Polysaccharides	133-139	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	154-159
21983541-0	2011	Crystal structure and role of glycans and dimerization in folding of neuronal leucine-rich repeat protein AMIGO-1.	Polysaccharides	30-37	adhesion molecule with Ig like domain 1	Homo sapiens	106-113
21970594-5	2011	The dissociation constants (K(D)) for these pairs as free glycans (106 and 19 muM, respectively) and streptavidin-tethered (142 and 50 muM respectively) were found.	Polysaccharides	58-65	latexin	Homo sapiens	78-81
21970594-5	2011	The dissociation constants (K(D)) for these pairs as free glycans (106 and 19 muM, respectively) and streptavidin-tethered (142 and 50 muM respectively) were found.	Polysaccharides	58-65	latexin	Homo sapiens	135-138
21970594-7	2011	Glycan detection (GlcNAc-streptavidin at 10 muM) is demonstrated at the single nanotube level as well by monitoring the fluorescence from individual SWNT sensors tethered to GafD lectin.	Polysaccharides	0-6	latexin	Homo sapiens	44-47
21945958-0	2011	Improving immunogenicity of HIV-1 envelope gp120 by glycan removal and immune complex formation.	Polysaccharides	52-58	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	43-48
21945958-10	2011	Similar results were achieved with a complex made with gp120 bearing an N448E mutation, confirming the importance of the N448-linked glycan in modulating gp120 immunogenicity.	Polysaccharides	133-139	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	55-60
21939225-4	2011	The most prominent observation was the consistent positive correlations between different forms of triantennary glycans and negative correlations between glycans containing core-fucose with MetS components including BMI, SBP, DBP, and fasting plasma glucose (FPG) simultaneously.	Polysaccharides	154-161	selenium binding protein 1	Homo sapiens	221-224
21939225-4	2011	The most prominent observation was the consistent positive correlations between different forms of triantennary glycans and negative correlations between glycans containing core-fucose with MetS components including BMI, SBP, DBP, and fasting plasma glucose (FPG) simultaneously.	Polysaccharides	154-161	D-box binding PAR bZIP transcription factor	Homo sapiens	226-229
21939225-6	2011	In the multivariate analysis, the level of monosialylated glycans (structure loadings = -0.776) was the most correlated with the MetS related risk factors, especially with SBP (structure loadings = 0.907).	Polysaccharides	58-65	selenium binding protein 1	Homo sapiens	172-175
21918170-3	2011	We recently identified polysaccharide krestin (PSK), a natural product extracted from medicinal mushroom Trametes versicolor, as a potent toll-like receptor 2 (TLR2) agonist.	Polysaccharides	23-37	toll like receptor 2	Homo sapiens	160-164
21993307-0	2011	Glycan analysis of glycoprotein pharmaceuticals: Evaluation of analytical approaches to Z number determination in pharmaceutical erythropoietin products.	Polysaccharides	0-6	erythropoietin	Homo sapiens	129-143
22068471-8	2011	POMT1/2 and POMGnT1, protein products of causative genes of WWS and MEB, respectively, are enzymes that directly catalyze the biosynthesis of this glycan.	Polysaccharides	147-153	protein O-mannosyltransferase 1	Homo sapiens	0-7
22068471-8	2011	POMT1/2 and POMGnT1, protein products of causative genes of WWS and MEB, respectively, are enzymes that directly catalyze the biosynthesis of this glycan.	Polysaccharides	147-153	protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)	Homo sapiens	12-19
21906649-2	2011	In this study, pneumococcal surface protein A (PspA) was used as a carrier protein for pneumococcal capsular polysaccharide serotype 14 as an alternative to broaden the vaccine coverage.	Polysaccharides	109-123	surfactant associated protein A1	Mus musculus	15-45
21906649-2	2011	In this study, pneumococcal surface protein A (PspA) was used as a carrier protein for pneumococcal capsular polysaccharide serotype 14 as an alternative to broaden the vaccine coverage.	Polysaccharides	109-123	surfactant associated protein A1	Mus musculus	47-51
21906649-3	2011	PspA was modified by reductive amination with formaldehyde in order to improve the specificity of the reaction between protein and polysaccharide, inhibiting polymerization and the gel formation reaction.	Polysaccharides	131-145	surfactant associated protein A1	Mus musculus	0-4
22114560-8	2011	It therefore appeared that gp180 provides part of a glycan shield for otherwise vulnerable viral epitopes.	Polysaccharides	52-58	protein tyrosine phosphatase receptor type C	Homo sapiens	27-32
22086115-8	2011	Alterations in the expression of key glycosyltransferase enzymes such as MGAT5 reflect the changes seen in the branching and sialylation of secreted glycans.	Polysaccharides	149-156	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	73-78
21723314-5	2011	The polysaccharide also raised IL-1beta, IL-8, IL-10 and TNF-alpha levels in cells infected with IBDV.	Polysaccharides	4-18	interleukin 1, beta	Gallus gallus	31-39
21723314-5	2011	The polysaccharide also raised IL-1beta, IL-8, IL-10 and TNF-alpha levels in cells infected with IBDV.	Polysaccharides	4-18	interleukin 8-like 2	Gallus gallus	41-45
21723314-5	2011	The polysaccharide also raised IL-1beta, IL-8, IL-10 and TNF-alpha levels in cells infected with IBDV.	Polysaccharides	4-18	interleukin 10	Gallus gallus	47-52
21723314-5	2011	The polysaccharide also raised IL-1beta, IL-8, IL-10 and TNF-alpha levels in cells infected with IBDV.	Polysaccharides	4-18	lipopolysaccharide induced TNF factor	Gallus gallus	57-66
21723424-1	2011	To assess the chemoprotective properties of a polysaccharide from Strongylocentrotus nudus eggs (SEP), myelosuppressed and immunosuppressed mouse models were generated by administration of cyclophosphamide (Cy) and then treated with SEP.	Polysaccharides	46-60	epoxide hydrolase 2, cytoplasmic	Mus musculus	97-100
21756932-0	2011	Hypoglycemic effects of MDG-1, a polysaccharide derived from Ophiopogon japonicas, in the ob/ob mouse model of type 2 diabetes mellitus.	Polysaccharides	33-47	DnaJ heat shock protein family (Hsp40) member B9	Mus musculus	24-29
21880749-0	2011	Host-soluble galectin-1 promotes HIV-1 replication through a direct interaction with glycans of viral gp120 and host CD4.	Polysaccharides	85-92	galectin 1	Homo sapiens	13-23
21880749-0	2011	Host-soluble galectin-1 promotes HIV-1 replication through a direct interaction with glycans of viral gp120 and host CD4.	Polysaccharides	85-92	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	102-107
21880749-6	2011	Unexpectedly, this preferential binding of galectin-1 does not rely on the primary sequence of any particular glycans.	Polysaccharides	110-117	galectin 1	Homo sapiens	43-53
21880749-7	2011	Instead, glycan clustering arising from the tertiary structure of gp120 hinders its binding by galectin-3.	Polysaccharides	9-15	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	66-71
21880749-7	2011	Instead, glycan clustering arising from the tertiary structure of gp120 hinders its binding by galectin-3.	Polysaccharides	9-15	galectin 3	Homo sapiens	95-105
21880749-9	2011	In this peculiar occurrence, glycan clustering is instead exploited to prevent binding of gp120 by galectin-3, which would lead to a biological dead-end for the virus.	Polysaccharides	29-35	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	90-95
21880749-9	2011	In this peculiar occurrence, glycan clustering is instead exploited to prevent binding of gp120 by galectin-3, which would lead to a biological dead-end for the virus.	Polysaccharides	29-35	galectin 3	Homo sapiens	99-109
21782025-7	2011	The attached glycans were susceptible to PNGase F digestion, but mostly resistant to Endo Hf digestion under denaturing conditions.	Polysaccharides	13-20	N-glycanase 1	Homo sapiens	41-47
21290483-4	2011	The insoluble MUC2 mucin was prepared and separated by gel electrophoresis, its relative amount estimated, its O-glycans released, and glycans analyzed by novel sensitive glycomics chromatography / mass spectrometry providing information on glycan structures and relative abundances.	Polysaccharides	113-120	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	14-18
21290483-4	2011	The insoluble MUC2 mucin was prepared and separated by gel electrophoresis, its relative amount estimated, its O-glycans released, and glycans analyzed by novel sensitive glycomics chromatography / mass spectrometry providing information on glycan structures and relative abundances.	Polysaccharides	113-119	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	14-18
21290483-10	2011	CONCLUSIONS: In the majority of the active UC patients MUC2 mucin has an altered glycan profile as compared to inactive UC and control patients.	Polysaccharides	81-87	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	55-59
21752569-3	2011	The glycans attached to Human IgA1 were removed from their attachment sites by an array of enzymes.	Polysaccharides	4-11	immunoglobulin heavy constant alpha 1	Homo sapiens	30-34
21533784-1	2011	Innate immune system is crucial in the pathogenesis of neurocysticercosis (NCC) and helminth glycans can induce anti-inflammatory milieu via toll-like receptor 4 (TLR4) dependent mechanisms.	Polysaccharides	93-100	toll like receptor 4	Homo sapiens	141-161
21533784-1	2011	Innate immune system is crucial in the pathogenesis of neurocysticercosis (NCC) and helminth glycans can induce anti-inflammatory milieu via toll-like receptor 4 (TLR4) dependent mechanisms.	Polysaccharides	93-100	toll like receptor 4	Homo sapiens	163-167
21917589-7	2011	At high EDEM1 levels, glycoprotein release is prevented and glycan interactions are no longer required, canceling the otherwise mandatory ERAD timing by mannose trimming and accelerating the targeting to degradation.	Polysaccharides	60-66	ER degradation enhancing alpha-mannosidase like protein 1	Homo sapiens	8-13
22080600-0	2011	AXY8 encodes an alpha-fucosidase, underscoring the importance of apoplastic metabolism on the fine structure of Arabidopsis cell wall polysaccharides.	Polysaccharides	134-149	1,2-alpha-L-fucosidase	Arabidopsis thaliana	0-4
21973321-2	2011	It contains a polysaccharide component known to induce granulocyte macrophage colony-stimulating factor (GM-CSF) production from murine splenocytes.	Polysaccharides	14-28	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	55-103
21973321-2	2011	It contains a polysaccharide component known to induce granulocyte macrophage colony-stimulating factor (GM-CSF) production from murine splenocytes.	Polysaccharides	14-28	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	105-111
21973321-4	2011	In this study, we investigated the water-soluble, polysaccharide components of Reishi (designated as MAK) in murine colitis induced by trinitrobenzene sulphonic acid (TNBS).	Polysaccharides	50-64	male germ cell-associated kinase	Mus musculus	101-104
24710292-4	2011	In this study, we newly identified vioR and vioM in a so-called viosamine island as biosynthetic genes for glycosylation of mVio in Pta 6605 by the mass spectrometry (MS) of flagellin glycan in the respective mutants.	Polysaccharides	184-190	Psyr_3466	Pseudomonas syringae pv. syringae B728a	174-183
24710292-6	2011	syringae B728a, which does not possess a viosamine island, has a different structure of glycan in its flagellin protein.	Polysaccharides	88-94	Psyr_3466	Pseudomonas syringae pv. syringae B728a	102-111
21880719-5	2011	To identify it, here we probed a glycan array with a soluble form of the CLEC4C ectodomain.	Polysaccharides	33-39	C-type lectin domain family 4 member C	Homo sapiens	73-79
21835174-3	2011	Prosaposin is also found in the extracellular space where it is secreted as a fully glycosylated (70 kDa) protein composed of complex glycans.	Polysaccharides	134-141	prosaposin	Homo sapiens	0-10
21757329-0	2011	Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes.	Polysaccharides	0-14	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	117-123
21862582-4	2011	We prepared highly purified chitosan and chitin and examined the capacity of these glycans to stimulate murine macrophages to release the inflammasome-associated cytokine IL-1beta.	Polysaccharides	83-90	interleukin 1 beta	Mus musculus	171-179
21862582-10	2011	Thus, the deacetylated polysaccharide chitosan potently activates the NLRP3 inflammasome in a phagocytosis-dependent manner.	Polysaccharides	23-37	NLR family, pyrin domain containing 3	Mus musculus	70-75
21880719-7	2011	Importantly, soluble CLEC4C bound peripheral blood leukocytes and tumor cells that express glycans with galactose residues at the non-reducing ends.	Polysaccharides	91-98	C-type lectin domain family 4 member C	Homo sapiens	21-27
21111695-0	2011	Up regulation of annexin A2 on murine H22 hepatocarcinoma cells induced by cartilage polysaccharide.	Polysaccharides	85-99	annexin A2	Mus musculus	17-27
21689629-6	2011	The analysis of site-specific glycan microheterogeneity was illustrated for the CD44 fusion protein.	Polysaccharides	30-36	CD44 molecule (Indian blood group)	Homo sapiens	80-84
21185892-0	2011	Polysaccharide nanogel gene delivery system with endosome-escaping function: Co-delivery of plasmid DNA and phospholipase A2.	Polysaccharides	0-14	phospholipase A2 group IB	Homo sapiens	108-124
21835922-6	2011	Siglec-E bound a wide range of sialylated structures in glycan arrays, had a preference for NeuAc versus NeuGc-terminated sequences and could recognize a set of sialoglycoproteins that included CD45, in lysates from activated T-lymphocytes.	Polysaccharides	56-62	sialic acid binding Ig-like lectin E	Mus musculus	0-8
21111695-4	2011	Proteomics indicated that both quantity and conformation of annexin A2 were changed after induced by cartilage polysaccharide.	Polysaccharides	111-125	annexin A2	Mus musculus	60-70
21111695-5	2011	Lastly, we found there was a major increase of annexin A2 mRNA on H22 cells induced by cartilage polysaccharide.	Polysaccharides	97-111	annexin A2	Mus musculus	47-57
21663560-1	2011	BACKGROUND: Transferrin (Tf) glycoform lacking one or two complete or incomplete glycan chains (i.e., asialo-monosialo- and disialo-Tf) typically appear in blood after chronic alcohol consumption, though recently it was reported that monosialo-Tf is associated with trisialo-Tf but not with alcohol consumption.	Polysaccharides	81-87	transferrin	Homo sapiens	12-23
21695413-5	2011	As to the pathogenesis, several studies suggest that galactose-deficient IgA1 is recognized by anti-glycan antibodies, leading to the formation of circulating immune complexes and their mesangial deposition, thereby inducing renal injury.	Polysaccharides	100-106	immunoglobulin heavy constant alpha 1	Homo sapiens	73-77
21715597-6	2011	Our study identifies GRFT-specific gp120 glycans and may provide information for the design of novel CBA antiviral strategies.	Polysaccharides	41-48	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	35-40
21551457-6	2011	The TF-positive capsular polysaccharide structure of strain D-6 was characterized by mass spectrometry, monosaccharide composition analysis, glycosidase treatments and immunoblot staining with TFalpha- and TFbeta-specific antibodies.	Polysaccharides	25-39	coagulation factor III, tissue factor	Homo sapiens	193-200
21725030-4	2011	In contrast, in cells subjected to QUA3 RNA interference (RNAi) knock-down there is less pectin methylation as well as altered composition and assembly of cell wall polysaccharides.	Polysaccharides	165-180	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	35-39
21188648-3	2011	Increasing evidence supports the underglycosylated IgA-containing immune-complex including IgG antibodies against the glycans of the hinge region of IgA1 are key factors for mesangial deposition and then trigger inflammation and glomerular injury.	Polysaccharides	118-125	immunoglobulin heavy constant alpha 1	Homo sapiens	149-153
21920605-8	2011	Periodate treatment of SAG abolished MBL pathway activation consistent with an involvement of SAG glycans in complement activation.	Polysaccharides	98-105	deleted in malignant brain tumors 1	Homo sapiens	23-26
21371544-0	2011	DC-SIGN mediated antigen-targeting using glycan-modified liposomes: formulation considerations.	Polysaccharides	41-47	CD209 molecule	Homo sapiens	0-7
21782821-1	2011	We recently constructed the scFv-displaying phage library with extremely high repertoire and have successfully utilized for screening scFv antibodies against various proteins, polysaccharides and glyco-lipids.	Polysaccharides	176-191	immunglobulin heavy chain variable region	Homo sapiens	28-32
21782821-1	2011	We recently constructed the scFv-displaying phage library with extremely high repertoire and have successfully utilized for screening scFv antibodies against various proteins, polysaccharides and glyco-lipids.	Polysaccharides	176-191	immunglobulin heavy chain variable region	Homo sapiens	134-138
21963624-0	2011	Down-regulation of Treg cells and up-regulation of TH1/TH2 cytokine ratio were induced by polysaccharide from Radix Glycyrrhizae in H22 hepatocarcinoma bearing mice.	Polysaccharides	90-104	negative elongation factor complex member C/D, Th1l	Mus musculus	51-54
21963624-0	2011	Down-regulation of Treg cells and up-regulation of TH1/TH2 cytokine ratio were induced by polysaccharide from Radix Glycyrrhizae in H22 hepatocarcinoma bearing mice.	Polysaccharides	90-104	heart and neural crest derivatives expressed 2	Mus musculus	55-58
21700274-1	2011	A polysaccharide, PGA4-3b, with an average molecular weight of 8.9kDa estimated by high-performance gel-permeation chromatography (HPGPC), was isolated from radix of Platycodon grandiflorum (Jacq.)	Polysaccharides	2-16	pepsinogen A4	Homo sapiens	18-22
21795704-5	2011	The expression of the AChE(T) mutant, in which all N-glycosylation sites were deleted, together with PRiMA in HEK293T cells produced a glycan-depleted PRiMA-linked AChE tetramer but with a much higher K(m) value as compared with the wild type.	Polysaccharides	135-141	acetylcholinesterase (Cartwright blood group)	Homo sapiens	22-26
21795704-5	2011	The expression of the AChE(T) mutant, in which all N-glycosylation sites were deleted, together with PRiMA in HEK293T cells produced a glycan-depleted PRiMA-linked AChE tetramer but with a much higher K(m) value as compared with the wild type.	Polysaccharides	135-141	proline rich membrane anchor 1	Homo sapiens	101-106
21795704-5	2011	The expression of the AChE(T) mutant, in which all N-glycosylation sites were deleted, together with PRiMA in HEK293T cells produced a glycan-depleted PRiMA-linked AChE tetramer but with a much higher K(m) value as compared with the wild type.	Polysaccharides	135-141	proline rich membrane anchor 1	Homo sapiens	151-156
21795704-5	2011	The expression of the AChE(T) mutant, in which all N-glycosylation sites were deleted, together with PRiMA in HEK293T cells produced a glycan-depleted PRiMA-linked AChE tetramer but with a much higher K(m) value as compared with the wild type.	Polysaccharides	135-141	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-168
21785785-0	2011	Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells.	Polysaccharides	25-31	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	121-126
21784847-0	2011	HNK-1 glycan functions as a tumor suppressor for astrocytic tumor.	Polysaccharides	6-12	beta-1,3-glucuronyltransferase 1	Homo sapiens	0-5
21784847-10	2011	Similarly, alpha-dystroglycan containing HNK-1 glycan is different from those containing the laminin-binding glycans, supporting the above conclusion that C6-HNK-1 cells migrate independently from beta1-integrin-mediated signaling.	Polysaccharides	23-29	beta-1,3-glucuronyltransferase 1	Homo sapiens	41-46
21784847-12	2011	Overall, these results indicate that HNK-1 glycan functions as a tumor suppressor.	Polysaccharides	43-49	beta-1,3-glucuronyltransferase 1	Homo sapiens	37-42
21665994-8	2011	These allelic effects are postulated to be caused by variation in availability of glucose-1-phosphate as a precursor of the glycan (PGM1), and variation in transferrin (TF) structure.	Polysaccharides	124-130	phosphoglucomutase 1	Homo sapiens	132-136
21660935-6	2011	Among them, synthetic peptides HPep1 and HPep6, which are located in the A and B box domains of HMGB1, bind to the polysaccharide and lipid A moieties of LPS respectively.	Polysaccharides	115-129	high mobility group box 1	Mus musculus	96-101
21514575-1	2011	For the investigation of glycosidases, and for the construction of glycan arrays the p-nitrophenyl- and p-aminophenyl glycosides of mucin O-glycan core structures 1-7 and the 2,6-ST-antigen have been chemically synthesized using d-galactose as a precursor for GalNAc residues.	Polysaccharides	67-73	LOC100508689	Homo sapiens	132-137
21640162-1	2011	BACKGROUND: Heparin-binding EGF-like growth factor (HB-EGF) contains, in contrast to EGF, a domain that binds to negatively charged glycans on cell surfaces and in extracellular matrix.	Polysaccharides	132-139	heparin binding EGF like growth factor	Homo sapiens	12-50
21640162-1	2011	BACKGROUND: Heparin-binding EGF-like growth factor (HB-EGF) contains, in contrast to EGF, a domain that binds to negatively charged glycans on cell surfaces and in extracellular matrix.	Polysaccharides	132-139	heparin binding EGF like growth factor	Homo sapiens	52-58
21640162-1	2011	BACKGROUND: Heparin-binding EGF-like growth factor (HB-EGF) contains, in contrast to EGF, a domain that binds to negatively charged glycans on cell surfaces and in extracellular matrix.	Polysaccharides	132-139	epidermal growth factor	Homo sapiens	28-31
21767596-7	2011	When stimulated with heat-inactivated bacteria, however, the polysaccharide-boosted mice did have higher levels of IFN-gamma and lower levels of IL-17 than both the CRM-neoglycoconjugate-boosted mice and the mock-immunized mice.	Polysaccharides	61-75	interferon gamma	Mus musculus	115-124
21767596-7	2011	When stimulated with heat-inactivated bacteria, however, the polysaccharide-boosted mice did have higher levels of IFN-gamma and lower levels of IL-17 than both the CRM-neoglycoconjugate-boosted mice and the mock-immunized mice.	Polysaccharides	61-75	interleukin 17A	Mus musculus	145-150
21341337-2	2011	In this study a polysaccharide fraction termed PLG was extracted from L. japonica in the Beibu Gulf in Guangxi, China, and its antithrombotic effects explored in rat models of carotid and venous thrombosis.	Polysaccharides	16-30	plasminogen	Homo sapiens	47-50
21697467-1	2011	The glycans on HIV-1 gp120 play an important role in shielding neutralization-sensitive epitopes from antibody recognition.	Polysaccharides	4-11	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	21-26
21697467-7	2011	The glycan at position 386, which shields the CD4bs, was involved in both GRFT-mediated enhancement of binding and neutralization synergism between GRFT and b12.	Polysaccharides	4-10	CD4 molecule	Homo sapiens	46-49
21697467-9	2011	This study shows for the first time that GRFT interaction with gp120 exposes the CD4bs through binding the glycan at position 386, which may have implications for how to access this conserved site.	Polysaccharides	107-113	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	63-68
21697467-9	2011	This study shows for the first time that GRFT interaction with gp120 exposes the CD4bs through binding the glycan at position 386, which may have implications for how to access this conserved site.	Polysaccharides	107-113	CD4 molecule	Homo sapiens	81-84
21203834-0	2011	Regulation of epidermal growth factor receptor through interaction of ganglioside GM3 with GlcNAc of N-linked glycan of the receptor: demonstration in ldlD cells.	Polysaccharides	110-116	epidermal growth factor receptor	Cricetulus griseus	14-46
21159783-3	2011	Glycan array analysis with more than 500 oligosaccharide structures revealed specific binding of Tra-1-60 and Tra-1-81 to two molecules containing terminal type 1 lactosamine: Galbeta1-3GlcNAcbeta1-3Galbeta1-4GlcNAc and Galbeta1-3GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-6(Galbeta1-3GlcNAcbeta1-3)Galbeta1-4Glc.	Polysaccharides	0-6	phospholipid scramblase 4	Homo sapiens	97-102
21159783-3	2011	Glycan array analysis with more than 500 oligosaccharide structures revealed specific binding of Tra-1-60 and Tra-1-81 to two molecules containing terminal type 1 lactosamine: Galbeta1-3GlcNAcbeta1-3Galbeta1-4GlcNAc and Galbeta1-3GlcNAcbeta1-3Galbeta1-4GlcNAcbeta1-6(Galbeta1-3GlcNAcbeta1-3)Galbeta1-4Glc.	Polysaccharides	0-6	phospholipid scramblase 4	Homo sapiens	110-115
21540232-0	2011	Comparative analysis reveals selective recognition of glycans by the dendritic cell receptors DC-SIGN and Langerin.	Polysaccharides	54-61	CD209 molecule	Homo sapiens	94-101
21909262-8	2011	Thus, the lack of 2F5 and 4E10 reverted unmutated ancestor binding to gp140 Env may not always be due to lack of unmutated ancestor antibody reactivity with gp41 peptide epitopes, but rather, may be due to glycan interference of binding of unmutated ancestor antibodies of broad neutralizing mAb to Env gp41.	Polysaccharides	206-212	endogenous retrovirus group K member 20	Homo sapiens	76-79
21909262-8	2011	Thus, the lack of 2F5 and 4E10 reverted unmutated ancestor binding to gp140 Env may not always be due to lack of unmutated ancestor antibody reactivity with gp41 peptide epitopes, but rather, may be due to glycan interference of binding of unmutated ancestor antibodies of broad neutralizing mAb to Env gp41.	Polysaccharides	206-212	endogenous retrovirus group K member 20	Homo sapiens	299-302
21769943-7	2011	Additionally, Asn135-linked oligosaccharide caused a bending in AT-bounded heparin, moving such polysaccharide away from helix D, which supports its reduced affinity for alpha-AT.	Polysaccharides	96-110	serpin family C member 1	Homo sapiens	64-66
21769943-9	2011	Such intramolecular rearrangements, together with heparin dynamics over AT surface, may support an atomic-level explanation for the Asn135-linked glycan influence over heparin binding and AT activation.	Polysaccharides	146-152	serpin family C member 1	Homo sapiens	72-74
21769943-9	2011	Such intramolecular rearrangements, together with heparin dynamics over AT surface, may support an atomic-level explanation for the Asn135-linked glycan influence over heparin binding and AT activation.	Polysaccharides	146-152	serpin family C member 1	Homo sapiens	188-190
21540232-7	2011	Notably, Ca(2+)-independent glycan-binding activity of Langerin could not be detected either by probing the glycan array or by isothermal titration calorimetry of the CRD with mannose and mannobiose.	Polysaccharides	28-34	CD207 molecule	Homo sapiens	55-63
21540232-0	2011	Comparative analysis reveals selective recognition of glycans by the dendritic cell receptors DC-SIGN and Langerin.	Polysaccharides	54-61	CD207 molecule	Homo sapiens	106-114
21540232-7	2011	Notably, Ca(2+)-independent glycan-binding activity of Langerin could not be detected either by probing the glycan array or by isothermal titration calorimetry of the CRD with mannose and mannobiose.	Polysaccharides	108-114	CD207 molecule	Homo sapiens	55-63
21540232-2	2011	DC-SIGN interacts with glycan structures on HIV-1, facilitating virus survival, transmission and infection, whereas Langerin, which is characteristic of Langerhans cells (LCs), promotes HIV-1 uptake and degradation.	Polysaccharides	23-29	CD209 molecule	Homo sapiens	0-7
21715322-6	2011	Knockdown of galectin-3 and Mgat5, an enzyme that synthesizes high-affinity glycan ligands of galectin-3, reduced VEGF-A mediated angiogenesis in vitro.	Polysaccharides	76-82	galectin 3	Homo sapiens	13-23
21878570-13	2011	Properdin colocalized with bound C3, suggesting that in the presence of serum, properdin bound indirectly to glycans through C3 convertases.	Polysaccharides	109-116	complement factor properdin	Homo sapiens	0-9
21878570-13	2011	Properdin colocalized with bound C3, suggesting that in the presence of serum, properdin bound indirectly to glycans through C3 convertases.	Polysaccharides	109-116	complement factor properdin	Homo sapiens	79-88
21878570-0	2011	Linkage specificity and role of properdin in activation of the alternative complement pathway by fungal glycans.	Polysaccharides	104-111	complement factor properdin	Homo sapiens	32-41
21878570-6	2011	AP activation by glycan particles that varied in composition and linkage was measured by C3a generation in serum treated with 10 mM EGTA and 10 mM Mg(2+) (Mg-EGTA-treated serum) (AP specific; properdin functional) or Mg-EGTA-treated serum that lacked functional properdin.	Polysaccharides	17-23	complement C3	Homo sapiens	89-92
21715322-6	2011	Knockdown of galectin-3 and Mgat5, an enzyme that synthesizes high-affinity glycan ligands of galectin-3, reduced VEGF-A mediated angiogenesis in vitro.	Polysaccharides	76-82	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	28-33
21715322-6	2011	Knockdown of galectin-3 and Mgat5, an enzyme that synthesizes high-affinity glycan ligands of galectin-3, reduced VEGF-A mediated angiogenesis in vitro.	Polysaccharides	76-82	galectin 3	Homo sapiens	94-104
21715322-6	2011	Knockdown of galectin-3 and Mgat5, an enzyme that synthesizes high-affinity glycan ligands of galectin-3, reduced VEGF-A mediated angiogenesis in vitro.	Polysaccharides	76-82	vascular endothelial growth factor A	Homo sapiens	114-120
21737688-4	2011	We characterize Erg3p and demonstrate that the elimination of Erg3p requires Htm1p and Yos9p, two proteins that take part in the glycan-dependent turnover of aberrant proteins.	Polysaccharides	129-135	ETS transcription factor ERG	Homo sapiens	16-21
21737688-4	2011	We characterize Erg3p and demonstrate that the elimination of Erg3p requires Htm1p and Yos9p, two proteins that take part in the glycan-dependent turnover of aberrant proteins.	Polysaccharides	129-135	ETS transcription factor ERG	Homo sapiens	62-67
21142800-8	2011	In conclusion, the N275 and N351 glycan sites on the CRF07_BC gp120 play an important role in mediating the interaction between gp120 and DC-SIGN.	Polysaccharides	33-39	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	62-67
21696869-9	2011	These results suggest that a FlaB-PspA fusion protein alone could be used as an anti-pneumococcal mucosal vaccine or as an effective partner protein for multivalent capsular polysaccharide conjugate vaccines.	Polysaccharides	174-188	surfactant associated protein A1	Mus musculus	34-38
24212951-6	2011	Profound research has been done on targeting specific tumor antigens to CLR using either antibodies or the natural ligands such as glycan structures.	Polysaccharides	131-137	doublecortin like kinase 3	Homo sapiens	72-75
21142800-8	2011	In conclusion, the N275 and N351 glycan sites on the CRF07_BC gp120 play an important role in mediating the interaction between gp120 and DC-SIGN.	Polysaccharides	33-39	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	128-133
21558494-8	2011	As a functional assay, MCF-7 cells were challenged with native and glycan-modified CBG and the amount of cAMP, which is produced as a quantitative response upon CBG binding to its cell surface receptor, was used to evaluate the CBG:receptor interaction.	Polysaccharides	67-73	serpin family A member 6	Homo sapiens	83-86
21669976-2	2011	Here, we show the KCNE1 regulatory subunit is O-glycosylated with mucin-type glycans in vivo.	Polysaccharides	77-84	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	18-23
21669976-2	2011	Here, we show the KCNE1 regulatory subunit is O-glycosylated with mucin-type glycans in vivo.	Polysaccharides	77-84	LOC100508689	Homo sapiens	66-71
21605112-0	2011	A critical role for FcgammaRIIB in up-regulation of Fas ligand induced by a microbial polysaccharide.	Polysaccharides	86-100	Fc gamma receptor IIb	Homo sapiens	20-31
21605112-0	2011	A critical role for FcgammaRIIB in up-regulation of Fas ligand induced by a microbial polysaccharide.	Polysaccharides	86-100	Fas ligand	Homo sapiens	52-62
21694730-2	2011	The cooperative binding of three segments of AH to three high mannose-type glycans (HMTGs) of HIV-1 gp120 generates specific and strong anti-HIV activity.	Polysaccharides	75-82	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	100-105
21535396-5	2011	Site-specific mutagenesis of one or more potential N-linked glycosylation sites in TF was used to generate TF mutants lacking glycans.	Polysaccharides	126-133	coagulation factor III, tissue factor	Homo sapiens	83-85
21535396-5	2011	Site-specific mutagenesis of one or more potential N-linked glycosylation sites in TF was used to generate TF mutants lacking glycans.	Polysaccharides	126-133	coagulation factor III, tissue factor	Homo sapiens	107-109
21696190-1	2011	Hyaluronan (HA) is a biocompatible and biodegradable linear polysaccharide which is of interest for tumor targeting through cell surface CD44 receptors.	Polysaccharides	60-74	CD44 molecule (Indian blood group)	Homo sapiens	137-141
21507958-3	2011	Bacteria colonizing the mucosal layer that overlies the gut epithelium are exposed to highly sulfated glycans (i.e. mucin and glycosaminoglycans).	Polysaccharides	102-109	LOC100508689	Homo sapiens	116-121
21442474-7	2011	Desialidation of the channel exposes glycan residues that promote binding to galectin-1, resulting in stabilization of residence on the plasma membrane.	Polysaccharides	37-43	galectin 1	Homo sapiens	77-87
21705653-4	2011	Expression of CESA5 in the seed coat was specific to epidermal cells and coincided with the accumulation of mucilage polysaccharides in their apoplast.	Polysaccharides	117-132	cellulose synthase 5	Arabidopsis thaliana	14-19
21632540-3	2011	EDEM1 has five N-linked glycosylation sites with the most C-terminal site recognized poorly cotranslationally, resulting in the accumulation of EDEM1 containing four or five glycans.	Polysaccharides	174-181	ER degradation enhancing alpha-mannosidase like protein 1	Homo sapiens	0-5
21632540-3	2011	EDEM1 has five N-linked glycosylation sites with the most C-terminal site recognized poorly cotranslationally, resulting in the accumulation of EDEM1 containing four or five glycans.	Polysaccharides	174-181	ER degradation enhancing alpha-mannosidase like protein 1	Homo sapiens	144-149
21613225-7	2011	Analysis of glycan-deleted LIF mutants demonstrated that loss of glycans bearing the majority of Man-6-P residues leads to higher steady-state levels of secreted LIF.	Polysaccharides	65-72	LIF interleukin 6 family cytokine	Homo sapiens	27-30
21613225-7	2011	Analysis of glycan-deleted LIF mutants demonstrated that loss of glycans bearing the majority of Man-6-P residues leads to higher steady-state levels of secreted LIF.	Polysaccharides	12-18	LIF interleukin 6 family cytokine	Homo sapiens	27-30
21709263-5	2011	We have determined the differences in glycan sequences of EGFR in both cells and observed higher sialylation and fucosylation of EGFR in CL1-5 than in CL1-0.	Polysaccharides	38-44	epidermal growth factor receptor	Homo sapiens	58-62
21613225-7	2011	Analysis of glycan-deleted LIF mutants demonstrated that loss of glycans bearing the majority of Man-6-P residues leads to higher steady-state levels of secreted LIF.	Polysaccharides	12-18	LIF interleukin 6 family cytokine	Homo sapiens	162-165
21650186-1	2011	Force-distance measurements have been used to examine differences in the interaction of the dendritic cell glycan-binding receptor DC-SIGN and the closely related endothelial cell receptor DC-SIGNR (L-SIGN) with membranes bearing glycan ligands.	Polysaccharides	107-113	CD209 molecule	Homo sapiens	131-138
21613225-7	2011	Analysis of glycan-deleted LIF mutants demonstrated that loss of glycans bearing the majority of Man-6-P residues leads to higher steady-state levels of secreted LIF.	Polysaccharides	65-72	LIF interleukin 6 family cytokine	Homo sapiens	162-165
21546828-6	2011	Ex-vivo glycan engineering has established that HCELL serves as a "bone marrow homing receptor".	Polysaccharides	8-14	CD44 molecule (Indian blood group)	Homo sapiens	48-53
21561871-5	2011	Binding to neutrophil glycoproteins is fucose-dependent, and mass spectrometry-based glycomic analysis of neutrophil and milk lactoferrin was used to establish a correlation between high affinity binding to SRCL and the presence of multiple clustered terminal Lewis(x) groups on a heterogeneous mixture of branched glycans, some with poly N-acetyllactosamine extensions.	Polysaccharides	315-322	collectin subfamily member 12	Homo sapiens	207-211
21561871-7	2011	The common presence of Lewis(x) groups in granule protein glycans can thus target granule proteins for clearance by SRCL.	Polysaccharides	58-65	collectin subfamily member 12	Homo sapiens	116-120
21999546-8	2011	A polysaccharide obtained by gel chromatography on Bio-Gel P-4 of the high molecular mass material from Rt120 had a toxic effect on tumor HeLa cells but was inactive against the normal human skin fibroblast cell line.	Polysaccharides	2-16	solute carrier family 10 member 4	Homo sapiens	59-62
21818613-3	2011	We measured the specific activities of carboxymethyl cellulase, xylanase, inulinase, and alpha-amylase against different polysaccharides in the feces of captive chimpanzees and evaluated the participation of the entodiniomorphid ciliate, Troglodytella abrassarti, in these activities.	Polysaccharides	121-136	alpha-amylase 1C	Pan troglodytes	89-102
21710557-7	2011	Our results revealed that properties of the MUC1 molecules from the three cell lines are different in terms of migrating position in SMME and glycan profile.	Polysaccharides	142-148	mucin 1, cell surface associated	Homo sapiens	44-48
22754010-2	2011	Currently, NAG is being produced by an environment-unfriendly chemical process using chitin, a polysaccharide present in abundance in the exoskeleton of crustaceans, as a substrate.	Polysaccharides	95-109	N-acetyl-alpha-glucosaminidase	Homo sapiens	11-14
21839368-4	2011	New data suggest that poorly galactosylated IgA1 O-glycoforms might act either as autoantigens driving the formation of glycan-specific antibodies, or antigens for cross-reactive antimicrobial antibodies.	Polysaccharides	120-126	immunoglobulin heavy constant alpha 1	Homo sapiens	44-48
21424616-0	2011	Increased galectin-1 expression in muscle of Astragalus polysaccharide-treated Type 1 diabetic mice.	Polysaccharides	56-70	lectin, galactose binding, soluble 1	Mus musculus	10-20
21471211-3	2011	Effective binding of FGF2 to its receptor requires the presence of heparan sulfate (HS), a linear polysaccharide with N-sulfated domains (NS) localized at the cell surface and extracellular matrix.	Polysaccharides	98-112	fibroblast growth factor 2	Homo sapiens	21-25
21700223-5	2011	Our results show that Pdi1p is engaged in both recognition and glycan signal processing of ERAD substrates and suggest that protein folding and breakdown are not separated but interconnected processes.	Polysaccharides	63-69	peptidyl arginine deiminase 1	Homo sapiens	22-27
21526855-6	2011	Ladder sequencing of the 17-18.5 kD MUC1 hexarepeat domains revealed (1) cell-specific glycosylation site patterns on comparison of probes expressed in human HEK-293 or Drosophila S2 cells, and (2) a site-specific microheterogeneity at the Thr/Ser sites with variations of the glycan compositions from zero to four monosaccharides.	Polysaccharides	277-283	mucin 1, cell surface associated	Homo sapiens	36-40
21515679-7	2011	Furthermore, we found that the alpha1-3,4-fucose moieties of Le glycans expressed on DC-SIGN-binding Mac-2BP were important for recognition.	Polysaccharides	64-71	CD209 molecule	Homo sapiens	85-92
21515679-7	2011	Furthermore, we found that the alpha1-3,4-fucose moieties of Le glycans expressed on DC-SIGN-binding Mac-2BP were important for recognition.	Polysaccharides	64-71	galectin 3 binding protein	Homo sapiens	101-108
21515679-9	2011	Importantly, Mac-2BP was detected as a predominant DC-SIGN ligand expressed on some primary colorectal cancer tissues from certain parts of patients in comparison with CEA from other parts, suggesting that DC-SIGN-binding Mac-2BP bearing tumor-associated Le glycans may become a novel potential colorectal cancer biomarker for some patients instead of CEA.	Polysaccharides	258-265	galectin 3 binding protein	Homo sapiens	13-20
21515679-9	2011	Importantly, Mac-2BP was detected as a predominant DC-SIGN ligand expressed on some primary colorectal cancer tissues from certain parts of patients in comparison with CEA from other parts, suggesting that DC-SIGN-binding Mac-2BP bearing tumor-associated Le glycans may become a novel potential colorectal cancer biomarker for some patients instead of CEA.	Polysaccharides	258-265	CD209 molecule	Homo sapiens	206-213
21515679-9	2011	Importantly, Mac-2BP was detected as a predominant DC-SIGN ligand expressed on some primary colorectal cancer tissues from certain parts of patients in comparison with CEA from other parts, suggesting that DC-SIGN-binding Mac-2BP bearing tumor-associated Le glycans may become a novel potential colorectal cancer biomarker for some patients instead of CEA.	Polysaccharides	258-265	galectin 3 binding protein	Homo sapiens	222-229
21493714-8	2011	These data show that Gal-1 and E-selectin ligand reduction by 4-F-GlcNAc is not caused by direct 4-F-GlcNAc glycan incorporation and consequent chain termination but rather by interference with UDP-GlcNAc synthesis.	Polysaccharides	108-114	selectin E	Homo sapiens	31-41
21130616-6	2011	Compared to matrix-free capsules, the matrix capsules had a much higher loading capacity up to four times; the driving force is mostly due to electrostatic interactions between myoglobin and the polysaccharide matrix.	Polysaccharides	195-209	myoglobin	Homo sapiens	177-186
21501631-2	2011	Here, we evaluated the combination of tenofovir with various members of the class of carbohydrate-binding agents (CBAs) targeting the glycans on the viral envelope gp120 for their anti-HIV efficacy.	Polysaccharides	134-141	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	164-169
21906357-7	2011	Discovery of specific cancer-associated aberrations in glycan structures of these existing biomarkers could improve their cancer specificity, such as the discovery of AFP-L3, fucosylated glycoforms of AFP.	Polysaccharides	55-61	alpha fetoprotein	Homo sapiens	167-170
21906357-7	2011	Discovery of specific cancer-associated aberrations in glycan structures of these existing biomarkers could improve their cancer specificity, such as the discovery of AFP-L3, fucosylated glycoforms of AFP.	Polysaccharides	55-61	alpha fetoprotein	Homo sapiens	201-204
21392166-3	2011	In the present study, we examined glycan structures in CD133+ CD13+ CSC, which were recently found to have a high CSC ability, by means of a lectin microarray.	Polysaccharides	34-40	prominin 1	Homo sapiens	55-60
21411530-3	2011	One major reason for such a meager NAb response is the phenomenon of glycan shielding involving GP5, a major glycoprotein carrying one major neutralizing epitope.	Polysaccharides	69-75	glycoprotein V platelet	Homo sapiens	96-99
21356237-1	2011	HPLC analysis proved that Coptis chinensis glycan contained Ara, Man, and Gal.	Polysaccharides	43-49	galanin and GMAP prepropeptide	Homo sapiens	74-77
21356237-3	2011	HPLC analysis proved that P. amurense glycan contained Ara, Xyl, Glu, and Gal.	Polysaccharides	38-44	galanin and GMAP prepropeptide	Homo sapiens	74-77
21416197-4	2011	Enzymes developed to treat Gaucher and Niemann-Pick diseases are meant to target MMR-expressing cells, and in the case of Cerezyme [recombinant human beta-glucocerebrosidase (rhbetaGC)] for treating Gaucher disease, glycans on the enzyme are modified to increase specificity toward this receptor.	Polysaccharides	216-223	glucosylceramidase beta	Homo sapiens	150-173
21411530-8	2011	Reintroduction of the N-glycosylation site in either GP3 or GP5 allowed recovery of in vivo and in vitro glycan shielding capacity, with an additive effect when these sites were reintroduced into both glycoproteins simultaneously.	Polysaccharides	105-111	glycoprotein V platelet	Homo sapiens	60-63
21410905-5	2011	We demonstrate that MC1R is N-glycosylated at Asn15 and Asn29, with structurally and functionally different glycan chains.	Polysaccharides	108-114	melanocortin 1 receptor	Homo sapiens	20-24
20694826-0	2011	Polysaccharides from Capsosiphon fulvescens stimulate the growth of IEC-6 Cells by activating the MAPK signaling pathway.	Polysaccharides	0-15	mitogen activated protein kinase 3	Rattus norvegicus	98-102
21380457-6	2011	Thus, alterations in the glycan structure of the haptoglobin beta chain may constitute significant spectral signatures of cirrhosis and HCC disease.	Polysaccharides	25-31	haptoglobin	Homo sapiens	49-60
21172390-6	2011	We also show that calnexin forms complexes with MOG and these interactions might be glycan-independent.	Polysaccharides	84-90	calnexin	Homo sapiens	18-26
21172390-6	2011	We also show that calnexin forms complexes with MOG and these interactions might be glycan-independent.	Polysaccharides	84-90	myelin oligodendrocyte glycoprotein	Homo sapiens	48-51
21433091-0	2011	Preparative enantiomeric separation of new selective CB2 receptor agonists by liquid chromatography on polysaccharide-based chiral stationary phases: determination of enantiomeric purity and assignment of absolute stereochemistry by X-ray structure analysis.	Polysaccharides	103-117	cannabinoid receptor 2	Homo sapiens	53-56
21454596-3	2011	The size of this polysaccharide, TA-1, was deduced by size-exclusion chromatography as 500 kDa.	Polysaccharides	17-31	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	33-37
21113146-6	2011	The functional interaction between Gal-1 and alpha(5)beta(1)-integrin was glycan dependent with alpha2,6-sialylation representing a switch-off signal.	Polysaccharides	74-80	galectin 1	Homo sapiens	35-40
21113146-7	2011	Desialylation of cell surface glycans resulted in increased electrophoretic mobility of alpha(5)beta(1)-integrin and facilitated Gal-1 binding and anoikis stimulation.	Polysaccharides	30-37	galectin 1	Homo sapiens	129-134
21372249-6	2011	Moreover, the monosaccharide GalNAc-O-linked to the CD43 peptide core was identified as an essential component of the UN1 epitope by glycosidase digestion of specific glycan branches.	Polysaccharides	167-173	sialophorin	Homo sapiens	52-56
21147166-0	2011	High polymeric IgA content facilitates recognition of microbial polysaccharide-natural serum antibody immune complexes by immobilized human galectin-1.	Polysaccharides	64-78	galectin 1	Homo sapiens	140-150
21380457-2	2011	Many studies have reported glycan changes of haptoglobin in diseases such as breast cancer and pancreatic cancer.	Polysaccharides	27-33	haptoglobin	Homo sapiens	45-56
21348501-5	2011	In contrast, 8 kDa gelsolin cross-beta-sheet oligomers and amyloid fibrils bind strongly to heparin, apparently because of electrostatic interactions between the negatively charged polysaccharide and a positively charged region of the 8 kDa gelsolin assemblies.	Polysaccharides	181-195	gelsolin	Homo sapiens	19-27
21525298-11	2011	These results demonstrate that PLN glycans are essential in OSNs for proper AC3 localization and function.	Polysaccharides	35-42	adenylate cyclase 3	Mus musculus	76-79
21343305-4	2011	Heparan sulfate is a linear sulfated polysaccharide that facilitates binding and action of some vascular growth factors such as FGF-2 and VEGF-A.	Polysaccharides	37-51	fibroblast growth factor 2	Mus musculus	128-133
21343305-4	2011	Heparan sulfate is a linear sulfated polysaccharide that facilitates binding and action of some vascular growth factors such as FGF-2 and VEGF-A.	Polysaccharides	37-51	vascular endothelial growth factor A	Mus musculus	138-144
21357684-10	2011	In applications, mutations at this position may facilitate the design of OST variants adapted to particular N-glycosylation sites to reduce the heterogeneity of glycan occupancy.	Polysaccharides	161-167	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	73-76
21333724-0	2011	Inhibitory effect of polysaccharides isolated from Angelica sinensis on hepcidin expression.	Polysaccharides	21-36	hepcidin antimicrobial peptide	Rattus norvegicus	72-80
21333726-0	2011	Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice.	Polysaccharides	33-47	pancreatic and duodenal homeobox 1	Mus musculus	107-112
21333726-0	2011	Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice.	Polysaccharides	33-47	insulin I	Mus musculus	113-122
21333726-0	2011	Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice.	Polysaccharides	33-47	glucokinase	Mus musculus	174-185
21333726-0	2011	Hybrid of 1-deoxynojirimycin and polysaccharide from mulberry leaves treat diabetes mellitus by activating PDX-1/insulin-1 signaling pathway and regulating the expression of glucokinase, phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in alloxan-induced diabetic mice.	Polysaccharides	33-47	glucose-6-phosphatase, catalytic	Mus musculus	225-246
21370880-0	2011	Characterization of annexin A1 glycan binding reveals binding to highly sulfated glycans with preference for highly sulfated heparan sulfate and heparin.	Polysaccharides	31-37	annexin A1	Homo sapiens	20-30
21370880-0	2011	Characterization of annexin A1 glycan binding reveals binding to highly sulfated glycans with preference for highly sulfated heparan sulfate and heparin.	Polysaccharides	81-88	annexin A1	Homo sapiens	20-30
21370880-2	2011	Binding of annexin A1 to glycans has been implicated in cell attachment and modulation of annexin A1 function.	Polysaccharides	25-32	annexin A1	Homo sapiens	11-21
21370880-2	2011	Binding of annexin A1 to glycans has been implicated in cell attachment and modulation of annexin A1 function.	Polysaccharides	25-32	annexin A1	Homo sapiens	90-100
21370880-3	2011	A detailed characterization of the glycan binding preferences of annexin A1 using carbohydrate microarrays and surface plasmon resonance served as a starting point to understand the role of glycan binding in annexin A1 function.	Polysaccharides	35-41	annexin A1	Homo sapiens	65-75
21370880-3	2011	A detailed characterization of the glycan binding preferences of annexin A1 using carbohydrate microarrays and surface plasmon resonance served as a starting point to understand the role of glycan binding in annexin A1 function.	Polysaccharides	190-196	annexin A1	Homo sapiens	65-75
21370880-3	2011	A detailed characterization of the glycan binding preferences of annexin A1 using carbohydrate microarrays and surface plasmon resonance served as a starting point to understand the role of glycan binding in annexin A1 function.	Polysaccharides	190-196	annexin A1	Homo sapiens	208-218
21370880-4	2011	Glycan array analysis identified annexin A1 binding to a series of sulfated oligosaccharides and revealed for the first time that annexin A1 binds to sulfated non-glycosaminoglycan carbohydrates.	Polysaccharides	0-6	annexin A1	Homo sapiens	33-43
21188584-1	2011	Bacterial cell wall polysaccharides, such as PGN, bind and activate TLR-2, NOD2 and PGRP on monocytes/macrophages and activate inflammation.	Polysaccharides	20-35	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	45-48
21370880-4	2011	Glycan array analysis identified annexin A1 binding to a series of sulfated oligosaccharides and revealed for the first time that annexin A1 binds to sulfated non-glycosaminoglycan carbohydrates.	Polysaccharides	0-6	annexin A1	Homo sapiens	130-140
21520232-2	2011	METHODS: A recombinant human HexA (Om4HexA) with a high mannose 6-phosphate (M6P)-type-N-glycan content, which was produced by a methylotrophic yeast strain, Ogataea minuta, overexpressing the OmMNN4 gene, was intracerebroventricularly (ICV) administered to Sandhoff disease model mice (Hexb-/- mice) at different doses (0.5-2.5 mg/kg), and then the replacement and therapeutic effects were examined.	Polysaccharides	89-95	hexosaminidase subunit alpha	Homo sapiens	29-33
21520232-2	2011	METHODS: A recombinant human HexA (Om4HexA) with a high mannose 6-phosphate (M6P)-type-N-glycan content, which was produced by a methylotrophic yeast strain, Ogataea minuta, overexpressing the OmMNN4 gene, was intracerebroventricularly (ICV) administered to Sandhoff disease model mice (Hexb-/- mice) at different doses (0.5-2.5 mg/kg), and then the replacement and therapeutic effects were examined.	Polysaccharides	89-95	hexosaminidase subunit alpha	Homo sapiens	38-42
21411219-8	2011	Cofilin and the polysaccharide polyanion heparin disassemble lysozyme induced actin bundles more effectively than the polylysine-induced bundles.	Polysaccharides	16-30	lysozyme	Homo sapiens	61-69
21188584-1	2011	Bacterial cell wall polysaccharides, such as PGN, bind and activate TLR-2, NOD2 and PGRP on monocytes/macrophages and activate inflammation.	Polysaccharides	20-35	toll like receptor 2	Homo sapiens	68-73
21188584-1	2011	Bacterial cell wall polysaccharides, such as PGN, bind and activate TLR-2, NOD2 and PGRP on monocytes/macrophages and activate inflammation.	Polysaccharides	20-35	nucleotide binding oligomerization domain containing 2	Homo sapiens	75-79
21188584-1	2011	Bacterial cell wall polysaccharides, such as PGN, bind and activate TLR-2, NOD2 and PGRP on monocytes/macrophages and activate inflammation.	Polysaccharides	20-35	peptidoglycan recognition protein 1	Homo sapiens	84-88
21062784-11	2011	Biochemical analysis demonstrated that the glycan altered association between TbetaR-I and TbetaR-II in the absence of ligands.	Polysaccharides	43-49	transforming growth factor, beta receptor I	Mus musculus	78-86
22022660-0	2011	Derivatization of free natural glycans for incorporation onto glycan arrays: derivatizing glycans on the microscale for microarray and other applications (ms# CP-10-0194).	Polysaccharides	31-38	S100 calcium binding protein A8	Homo sapiens	159-164
22022660-0	2011	Derivatization of free natural glycans for incorporation onto glycan arrays: derivatizing glycans on the microscale for microarray and other applications (ms# CP-10-0194).	Polysaccharides	31-37	S100 calcium binding protein A8	Homo sapiens	159-164
22022660-0	2011	Derivatization of free natural glycans for incorporation onto glycan arrays: derivatizing glycans on the microscale for microarray and other applications (ms# CP-10-0194).	Polysaccharides	90-97	S100 calcium binding protein A8	Homo sapiens	159-164
21488041-2	2011	The advent of glycan microarrays has revolutionized the field of glycobiology by allowing simultaneous screening of a GBP for interactions with a large set of glycans in a single format.	Polysaccharides	14-20	transmembrane protein 132A	Homo sapiens	118-121
21488041-2	2011	The advent of glycan microarrays has revolutionized the field of glycobiology by allowing simultaneous screening of a GBP for interactions with a large set of glycans in a single format.	Polysaccharides	159-166	transmembrane protein 132A	Homo sapiens	118-121
21062784-11	2011	Biochemical analysis demonstrated that the glycan altered association between TbetaR-I and TbetaR-II in the absence of ligands.	Polysaccharides	43-49	transforming growth factor, beta receptor II	Mus musculus	91-100
21383159-2	2011	UGT1 recognizes disordered or hydrophobic patches near asparagine-linked nonglucosylated glycans in partially misfolded glycoproteins and reglucosylates them, returning folding intermediates to the cycle.	Polysaccharides	89-96	UDP-glucose glycoprotein glucosyltransferase 1	Mus musculus	0-4
21288902-0	2011	Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans.	Polysaccharides	70-77	galectin 8	Homo sapiens	0-10
21651844-0	2011	[The regulatory effect and mechanism of Astragalus polysaccharides on CD11c(high)CD45RB(low) dendritic cell].	Polysaccharides	51-66	integrin subunit alpha X	Homo sapiens	70-75
20971194-7	2011	Neogenin FN5, which does not bind hemojuvelin in isolation, exhibits a highly electropositive surface, which may be involved in interactions with negatively-charged polysaccharides or phospholipids in the membrane bilayer.	Polysaccharides	165-180	neogenin 1	Homo sapiens	0-8
21478444-9	2011	Examination of cell wall polysaccharide preparations from RGP1 and RGP2 knockout mutants showed a significant reduction in total L-Ara content (12-31%) compared with wild-type plants.	Polysaccharides	25-39	reversibly glycosylated polypeptide 1	Arabidopsis thaliana	58-62
21383180-9	2011	Collectively, the data indicate that CRT in the PLC enhances weak tapasin/class I interactions in a manner that is glycan-dependent and regulated by UDP-glucose:glycoprotein glucosyltransferase 1.	Polysaccharides	115-121	Calreticulin	Drosophila melanogaster	37-40
21329668-0	2011	Binding of natural cytotoxicity receptor NKp46 to sulfate- and alpha2,3-NeuAc-containing glycans and its mutagenesis.	Polysaccharides	89-96	natural cytotoxicity triggering receptor 1	Homo sapiens	41-46
21357742-2	2011	We previously identified Dectin-2 as a receptor for glycans in allergen extracts from the house dust mite Dermatophagoides farinae (Df) that mediates cysteinyl leukotriene (cys-LT) generation from pulmonary CD11c+ cells and from GM-CSF-cultured bone marrow cells (BMCs(GM-CSF)).	Polysaccharides	52-59	C-type lectin domain family 4, member n	Mus musculus	25-33
21329668-6	2011	Moreover, mutants R139Q, R145Q, and K149Q had significantly reduced binding to these sulfate-containing glycans, and K136Q and K149Q to HepTF, indicating that NKp46 binds to sulfate- and 2,3-NeuAc-containing glycans mainly via ionic interactions.	Polysaccharides	104-111	natural cytotoxicity triggering receptor 1	Homo sapiens	159-164
21329668-6	2011	Moreover, mutants R139Q, R145Q, and K149Q had significantly reduced binding to these sulfate-containing glycans, and K136Q and K149Q to HepTF, indicating that NKp46 binds to sulfate- and 2,3-NeuAc-containing glycans mainly via ionic interactions.	Polysaccharides	208-215	natural cytotoxicity triggering receptor 1	Homo sapiens	159-164
21329670-4	2011	Characterization of glycans expressed on breast cancer cells by a panel of antibodies revealed that BT-20 cells expressed sialyl Lewis X (sLe(x)) and sialyl Lewis A (sLe(a)) but MDA-MB-468 cells did not, suggesting that the former possess classical glycans involved in E-selectin mediated adhesion while the latter have novel binding epitopes.	Polysaccharides	20-27	selectin E	Homo sapiens	269-279
20473945-0	2011	Tumour-associated glycan modifications of antigen enhance MGL2 dependent uptake and MHC class I restricted CD8 T cell responses.	Polysaccharides	18-24	CD8a molecule	Homo sapiens	107-110
20473945-3	2011	Glycan-modification of antigen with GalNAc that mimics tumour-associated glycosylation, promoted antigen internalisation in DCs and presentation to CD4 T cells, as well as differentiation of IFN-gamma producing CD4 T cells.	Polysaccharides	0-6	CD4 molecule	Homo sapiens	148-151
20473945-3	2011	Glycan-modification of antigen with GalNAc that mimics tumour-associated glycosylation, promoted antigen internalisation in DCs and presentation to CD4 T cells, as well as differentiation of IFN-gamma producing CD4 T cells.	Polysaccharides	0-6	interferon gamma	Homo sapiens	191-200
20473945-3	2011	Glycan-modification of antigen with GalNAc that mimics tumour-associated glycosylation, promoted antigen internalisation in DCs and presentation to CD4 T cells, as well as differentiation of IFN-gamma producing CD4 T cells.	Polysaccharides	0-6	CD4 molecule	Homo sapiens	211-214
20615996-9	2011	This observation that normal human individuals carry a uniform MUC2 mucin glycan array in colon may indicate such a specific selection.	Polysaccharides	74-80	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	63-67
20615996-9	2011	This observation that normal human individuals carry a uniform MUC2 mucin glycan array in colon may indicate such a specific selection.	Polysaccharides	74-80	LOC100508689	Homo sapiens	68-73
21357742-2	2011	We previously identified Dectin-2 as a receptor for glycans in allergen extracts from the house dust mite Dermatophagoides farinae (Df) that mediates cysteinyl leukotriene (cys-LT) generation from pulmonary CD11c+ cells and from GM-CSF-cultured bone marrow cells (BMCs(GM-CSF)).	Polysaccharides	52-59	integrin subunit alpha X	Homo sapiens	207-212
21357742-2	2011	We previously identified Dectin-2 as a receptor for glycans in allergen extracts from the house dust mite Dermatophagoides farinae (Df) that mediates cysteinyl leukotriene (cys-LT) generation from pulmonary CD11c+ cells and from GM-CSF-cultured bone marrow cells (BMCs(GM-CSF)).	Polysaccharides	52-59	colony stimulating factor 2	Homo sapiens	229-235
21357742-2	2011	We previously identified Dectin-2 as a receptor for glycans in allergen extracts from the house dust mite Dermatophagoides farinae (Df) that mediates cysteinyl leukotriene (cys-LT) generation from pulmonary CD11c+ cells and from GM-CSF-cultured bone marrow cells (BMCs(GM-CSF)).	Polysaccharides	52-59	colony stimulating factor 2	Homo sapiens	269-275
21133419-6	2011	We also established the glycan profile of prostate specific membrane antigen (PSMA) using the TSA and ALM.	Polysaccharides	24-30	folate hydrolase 1	Homo sapiens	42-76
21133419-6	2011	We also established the glycan profile of prostate specific membrane antigen (PSMA) using the TSA and ALM.	Polysaccharides	24-30	folate hydrolase 1	Homo sapiens	78-82
21280662-2	2011	The computerized approach CASPER, an acronym for computer assisted spectrum evaluation of regular polysaccharides, uses liquid state NMR data to elucidate carbohydrate structure based on agreement with predicted (1)H and (13)C chemical shifts.	Polysaccharides	98-113	CASP8 and FADD like apoptosis regulator	Homo sapiens	26-32
21133419-4	2011	We demonstrate that TSA increased the sensitivity of the microarray over 100 times for glycan profiling using the model protein prostate specific antigen (PSA).	Polysaccharides	87-93	kallikrein related peptidase 3	Homo sapiens	128-153
21133419-4	2011	We demonstrate that TSA increased the sensitivity of the microarray over 100 times for glycan profiling using the model protein prostate specific antigen (PSA).	Polysaccharides	87-93	kallikrein related peptidase 3	Homo sapiens	155-158
21133419-5	2011	The glycan profile of PSA enriched from LNCAP cells, obtained at a subnanogram level with the aid of TSA, was consistent with the previous reports.	Polysaccharides	4-10	kallikrein related peptidase 3	Homo sapiens	22-25
20978011-6	2011	We demonstrated that overexpression of Man2C1 led to modifications of the cytosolic pool of free oligomannosides and resulted in accumulation of small Man(2-4)GlcNAc(1) glycans in the cytosol.	Polysaccharides	169-176	mannosidase alpha class 2C member 1	Homo sapiens	39-45
21094672-11	2011	These results emphasize the relevance of both properties, i.e., glycan-binding and cross-linking of glycan moieties, for the inhibitory activity of galectin-3.	Polysaccharides	64-70	galectin 3	Homo sapiens	148-158
21094672-11	2011	These results emphasize the relevance of both properties, i.e., glycan-binding and cross-linking of glycan moieties, for the inhibitory activity of galectin-3.	Polysaccharides	100-106	galectin 3	Homo sapiens	148-158
21301336-3	2011	Aberrant O-linked galactosylation of IgA subclass (IgA1) appears to play a central role and "auto-immunity" to a conformational epitope related to glycans at the hinge region of IgA1 is apparently required.	Polysaccharides	147-154	immunoglobulin heavy constant alpha 1	Homo sapiens	51-55
21301336-3	2011	Aberrant O-linked galactosylation of IgA subclass (IgA1) appears to play a central role and "auto-immunity" to a conformational epitope related to glycans at the hinge region of IgA1 is apparently required.	Polysaccharides	147-154	immunoglobulin heavy constant alpha 1	Homo sapiens	178-182
21145343-2	2011	The crude and fractionated polysaccharides (F(1), F(2), and F(3)) consisted mostly of carbohydrates (58.3-91.9%), uronic acids (0-21.8%) and sulfates (1.8-17.7%) as well as varying amounts of proteins (1.6-9.4%).	Polysaccharides	27-42	coagulation factor II	Mus musculus	50-54
21191086-0	2011	Neisseria meningitidis capsular polysaccharides induce inflammatory responses via TLR2 and TLR4-MD-2.	Polysaccharides	32-47	toll-like receptor 2	Mus musculus	82-86
21191086-0	2011	Neisseria meningitidis capsular polysaccharides induce inflammatory responses via TLR2 and TLR4-MD-2.	Polysaccharides	32-47	toll-like receptor 4	Mus musculus	91-95
21387013-8	2011	Furthermore, only parent sulfated polysaccharides from L. saccharina (L.s.-P) and its fraction L.s.-1.25 were powerful inhibitors of basic fibroblast growth factor (bFGF) induced pathways.	Polysaccharides	34-49	fibroblast growth factor 2	Homo sapiens	165-169
21212300-4	2011	We have analyzed four Arabidopsis (Arabidopsis thaliana) homologs of the protein Cas1p known to be involved in polysaccharide O-acetylation in Cryptococcus neoformans.	Polysaccharides	111-125	cycloartenol synthase 1	Arabidopsis thaliana	81-86
21248261-0	2011	Suppressive effect of bacterial polysaccharides on BAFF system is responsible for their poor immunogenicity.	Polysaccharides	32-47	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	51-55
21091438-1	2011	Gal (galectin)-8 is a tandem-repeat Gal containing N-CRDs (Nterminal carbohydrate-recognition domains) and C-CRDs (C-terminal carbohydrate-recognition domains) with differential glycan-binding specificity fused by a linker peptide.	Polysaccharides	178-184	galectin 8	Homo sapiens	0-16
21246150-1	2011	We have exploited novel supramolecular wrapping techniques by helix-forming polysaccharides, beta-1,3-glucans, which have strong tendency to form regular helical structures on versatile nanomaterials in an induced-fit manner.	Polysaccharides	76-91	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	93-101
21195444-2	2011	By mutation of the glycosylation sites in these proteins, the studies show that glycan addition at N184 of GP2, N42, N50 and N131 of GP3 is necessary for infectious virus production.	Polysaccharides	80-86	glycoprotein 2	Homo sapiens	107-110
21248261-3	2011	In this study, we investigated the effect of bacterial polysaccharides on B cell responses to BAFF and a proliferation-inducing ligand (APRIL).	Polysaccharides	55-70	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	94-98
21248261-3	2011	In this study, we investigated the effect of bacterial polysaccharides on B cell responses to BAFF and a proliferation-inducing ligand (APRIL).	Polysaccharides	55-70	tumor necrosis factor (ligand) superfamily, member 13	Mus musculus	103-134
21263072-0	2011	Distinct functions for the glycans of tapasin and heavy chains in the assembly of MHC class I molecules.	Polysaccharides	27-34	TAP binding protein	Homo sapiens	38-45
21263072-3	2011	We show that the recruitments of CRT and ERp57 to the PLC are codependent and also dependent upon the ERp57 binding site and the glycan of the assembly factor tapasin.	Polysaccharides	129-135	calreticulin	Homo sapiens	33-36
21263072-3	2011	We show that the recruitments of CRT and ERp57 to the PLC are codependent and also dependent upon the ERp57 binding site and the glycan of the assembly factor tapasin.	Polysaccharides	129-135	protein disulfide isomerase family A member 3	Homo sapiens	41-46
21263072-3	2011	We show that the recruitments of CRT and ERp57 to the PLC are codependent and also dependent upon the ERp57 binding site and the glycan of the assembly factor tapasin.	Polysaccharides	129-135	TAP binding protein	Homo sapiens	159-166
20943674-12	2011	These data provide an important foundation for further studies of glycan structure/function relationships for hLF and rhLF and help to better understand the glycosylation mechanism in bovine mammary epithelial cells.	Polysaccharides	66-72	HLF transcription factor, PAR bZIP family member	Homo sapiens	110-113
21219866-1	2011	Protein-bound polysaccharide K (PSK) is a clinical immunotherapeutic agent that exhibits various biological activities, including anti-tumor and anti-microbial effects.	Polysaccharides	14-28	TAO kinase 2	Mus musculus	32-35
21347371-0	2011	Novel sulfated polysaccharides disrupt cathelicidins, inhibit RAGE and reduce cutaneous inflammation in a mouse model of rosacea.	Polysaccharides	15-30	advanced glycosylation end product-specific receptor	Mus musculus	62-66
21347371-9	2011	CONCLUSIONS: Anionic polysaccharides, exemplified by SAGEs, offer potential as novel mechanism-based therapies for rosacea and by extension other LL-37-mediated and RAGE-ligand driven skin diseases.	Polysaccharides	21-36	cathelicidin antimicrobial peptide	Homo sapiens	146-151
21347371-9	2011	CONCLUSIONS: Anionic polysaccharides, exemplified by SAGEs, offer potential as novel mechanism-based therapies for rosacea and by extension other LL-37-mediated and RAGE-ligand driven skin diseases.	Polysaccharides	21-36	advanced glycosylation end product-specific receptor	Mus musculus	165-169
21347376-6	2011	Introducing the wild-type DPM2 cDNA, the deficient gene in the Lec15.2 cells, fully restored the Large-induced functional glycosylation, suggesting that Large induces the functional glycans in a DPM2/O-mannosylation dependent manner.	Polysaccharides	182-189	dolichol phosphate-mannose biosynthesis regulatory protein	Cricetulus griseus	26-30
21347376-6	2011	Introducing the wild-type DPM2 cDNA, the deficient gene in the Lec15.2 cells, fully restored the Large-induced functional glycosylation, suggesting that Large induces the functional glycans in a DPM2/O-mannosylation dependent manner.	Polysaccharides	182-189	dolichol phosphate-mannose biosynthesis regulatory protein	Cricetulus griseus	195-199
20395633-0	2011	Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs.	Polysaccharides	34-40	sialic acid binding Ig-like lectin F	Mus musculus	53-61
20395633-1	2011	Sialic acid-binding immunoglobulin-like lectin (Siglec)-F, an inhibitory receptor on mouse eosinophils, preferentially recognizes the glycan ligand 6"-sulfated sialyl Lewis X, but little is known about the requirements for its lung expression.	Polysaccharides	134-140	sialic acid binding Ig-like lectin F	Mus musculus	0-57
21070836-0	2011	Human galectin-3 (Mac-2 antigen): defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region.	Polysaccharides	134-140	galectin 3	Homo sapiens	6-16
21070836-0	2011	Human galectin-3 (Mac-2 antigen): defining molecular switches of affinity to natural glycoproteins, structural and dynamic aspects of glycan binding by flexible ligand docking and putative regulatory sequences in the proximal promoter region.	Polysaccharides	134-140	galectin 3	Homo sapiens	18-31
21112773-7	2011	GPC3 is also able to bind basic growth factors such as fibroblast growth factor 2 through its heparan sulphate glycan chains.	Polysaccharides	111-117	glypican 3	Homo sapiens	0-4
21112773-7	2011	GPC3 is also able to bind basic growth factors such as fibroblast growth factor 2 through its heparan sulphate glycan chains.	Polysaccharides	111-117	fibroblast growth factor 2	Homo sapiens	55-81
21115491-9	2011	Endogenous LEC-6 and LEC-10 are expressed in the intestinal cells, but they are localized to different subcellular compartments that do not appear to overlap with each other or with the location of their glycan targets.	Polysaccharides	204-210	Galectin	Caenorhabditis elegans	11-16
21115491-9	2011	Endogenous LEC-6 and LEC-10 are expressed in the intestinal cells, but they are localized to different subcellular compartments that do not appear to overlap with each other or with the location of their glycan targets.	Polysaccharides	204-210	Galectin	Caenorhabditis elegans	21-27
21115491-11	2011	These results suggest a model where LEC-6 and LEC-10 interact with glycoproteins through specific glycans to regulate their cellular fate.	Polysaccharides	98-105	Galectin	Caenorhabditis elegans	36-41
21115491-11	2011	These results suggest a model where LEC-6 and LEC-10 interact with glycoproteins through specific glycans to regulate their cellular fate.	Polysaccharides	98-105	Galectin	Caenorhabditis elegans	46-52
21205799-6	2011	Characterization of Golgi compartmentation markers indicates altered colocalization that is consistent with the detected shift in glycan complexity in sff mutant embryos.	Polysaccharides	130-136	sugar-free frosting	Drosophila melanogaster	151-154
21205799-8	2011	Furthermore, neuronal sff expression is dependent on transcellular signaling through a non-neural toll-like receptor, linking neural-specific glycan expression to a kinase activity that is induced in response to environmental cues.	Polysaccharides	142-148	sugar-free frosting	Drosophila melanogaster	22-25
21075835-1	2011	Glycogen storage disease type IV (GSD-IV) is an autosomal recessive disease caused by a deficiency in glycogen-branching enzyme (GBE1) activity that results in the accumulation of amylopectin-like polysaccharide, which presumably leads to osmotic swelling and cell death.	Polysaccharides	197-211	glucan (1,4-alpha-), branching enzyme 1	Mus musculus	102-127
21075835-1	2011	Glycogen storage disease type IV (GSD-IV) is an autosomal recessive disease caused by a deficiency in glycogen-branching enzyme (GBE1) activity that results in the accumulation of amylopectin-like polysaccharide, which presumably leads to osmotic swelling and cell death.	Polysaccharides	197-211	glucan (1,4-alpha-), branching enzyme 1	Mus musculus	129-133
21078848-2	2011	Previous studies in a Drosophila melanogaster model showed that binding of ACP to the sulfated polysaccharide chains (glycosaminoglycans) of HSPGs promotes host death and is associated with higher bacterial burdens.	Polysaccharides	95-109	Accessory gland protein 26Ab	Drosophila melanogaster	75-78
21098104-0	2011	The Vi capsular polysaccharide prevents complement receptor 3-mediated clearance of Salmonella enterica serotype Typhi.	Polysaccharides	16-30	integrin alpha M	Mus musculus	40-61
21167231-5	2011	Furthermore, vSAT1tc displayed a high affinity for CHO-K1 cells possibly via interaction with negatively charged sulphated polysaccharides while SAT1 impala strain relied strongly on alpha(V)beta6 integrin receptors for cell entry.	Polysaccharides	123-138	diamine acetyltransferase 1	Cricetulus griseus	14-18
21228116-4	2011	Here we present evidence that S100A8/A9 interact with RAGE and carboxylated glycans on colon tumor cells and promote activation of MAPK and NF-kappaB signaling pathways.	Polysaccharides	76-83	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	30-36
21071493-1	2011	The ferric uptake regulator Fur has been reported to repress the expression of rmpA, a regulatory gene for the mucoid phenotype, leading to decreased capsular polysaccharide (CPS) biosynthesis in Klebsiella pneumoniae CG43.	Polysaccharides	159-173	regulator of mucoid phenotype	Klebsiella pneumoniae CG43	79-83
21112338-0	2011	Structural basis for langerin recognition of diverse pathogen and mammalian glycans through a single binding site.	Polysaccharides	76-83	CD207 molecule	Homo sapiens	21-29
21075854-1	2011	We define two classes of calreticulin mutants that retain glycan binding activity; those that display enhanced or reduced polypeptide-specific chaperone activity, due to conformational effects.	Polysaccharides	58-64	calreticulin	Homo sapiens	25-37
21112338-2	2011	Langerin binds to an unusually diverse number of endogenous and pathogenic cell surface carbohydrates, including mannose-containing O-specific polysaccharides derived from bacterial lipopolysaccharides identified here by probing a microarray of bacterial polysaccharides.	Polysaccharides	143-158	CD207 molecule	Homo sapiens	0-8
21059814-7	2011	Further, exogenous galectin-3 at concentrations similar to that found in the sera of PC patients interacts with MUC4 via surface glycans such as T antigens, which results in the clustering of MUC4 on the cell surface and a stronger attachment (locking) of circulating tumor cells to the endothelium.	Polysaccharides	129-136	galectin 3	Homo sapiens	19-29
21059814-7	2011	Further, exogenous galectin-3 at concentrations similar to that found in the sera of PC patients interacts with MUC4 via surface glycans such as T antigens, which results in the clustering of MUC4 on the cell surface and a stronger attachment (locking) of circulating tumor cells to the endothelium.	Polysaccharides	129-136	mucin 4, cell surface associated	Homo sapiens	112-116
21059814-7	2011	Further, exogenous galectin-3 at concentrations similar to that found in the sera of PC patients interacts with MUC4 via surface glycans such as T antigens, which results in the clustering of MUC4 on the cell surface and a stronger attachment (locking) of circulating tumor cells to the endothelium.	Polysaccharides	129-136	mucin 4, cell surface associated	Homo sapiens	192-196
21047777-3	2011	This study describes crystal structures of calcium-dependent complexes of the C-terminal neck and carbohydrate recognition domain of SP-A with d-mannose, D-alpha-methylmannose, and glycerol, which represent subdomains of glycans on pathogen surfaces.	Polysaccharides	221-228	surfactant protein A1	Homo sapiens	133-137
21288816-1	2011	Mannose-binding lectin (MBL) targets diverse microorganisms for phagocytosis and complement-mediated lysis by binding specific surface glycans.	Polysaccharides	135-142	mannose binding lectin 2	Homo sapiens	24-27
21865691-0	2011	Aberrant glycosylation of IgA1 and anti-glycan antibodies in IgA nephropathy: role of mucosal immune system.	Polysaccharides	40-46	IGAN1	Homo sapiens	61-76
21233534-5	2011	Molecular modelling of the gp120 glycans of simian immunodeficiency virus was undertaken to ascertain a theoretical minimum length of the linker unit.	Polysaccharides	33-40	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	27-32
21720027-5	2011	Furthermore, these two domains had significantly lower affinities for the LEC-6-binding glycans.	Polysaccharides	88-95	Galectin	Caenorhabditis elegans	74-79
21265802-4	2011	FimH can recognize equally the (single) high-mannose glycan on uroplakin Ia, on the urinary defence protein uromodulin or Tamm-Horsfall glycoprotein and on the intestinal GP2 glycoprotein present in Peyer"s patches.	Polysaccharides	53-59	uroplakin 1A	Homo sapiens	63-75
21212510-5	2011	These results suggested that these glycans can interact with NKG2D and CD94 to modulate NK cell-dependent cytotoxicity.	Polysaccharides	35-42	killer cell lectin like receptor K1	Homo sapiens	61-66
21212510-5	2011	These results suggested that these glycans can interact with NKG2D and CD94 to modulate NK cell-dependent cytotoxicity.	Polysaccharides	35-42	killer cell lectin like receptor D1	Homo sapiens	71-75
21467632-0	2011	Natural killer group 2A (NKG2A) and natural killer group 2C (NKG2C) bind to sulfated glycans and alpha2,3-NeuAc-containing glycoproteins.	Polysaccharides	85-92	killer cell lectin like receptor C1	Homo sapiens	0-23
21467632-0	2011	Natural killer group 2A (NKG2A) and natural killer group 2C (NKG2C) bind to sulfated glycans and alpha2,3-NeuAc-containing glycoproteins.	Polysaccharides	85-92	killer cell lectin like receptor C1	Homo sapiens	25-30
21467632-0	2011	Natural killer group 2A (NKG2A) and natural killer group 2C (NKG2C) bind to sulfated glycans and alpha2,3-NeuAc-containing glycoproteins.	Polysaccharides	85-92	killer cell lectin like receptor C2	Homo sapiens	61-66
21068144-0	2011	Polysaccharide krestin is a novel TLR2 agonist that mediates inhibition of tumor growth via stimulation of CD8 T cells and NK cells.	Polysaccharides	0-14	toll-like receptor 2	Mus musculus	34-38
20850471-6	2011	Here, we report a new mushroom polysaccharides extraction and fractionation method, with which we produced four fractions of PG with PG-2 appearing effective anti-tumour activity.	Polysaccharides	31-46	delta like non-canonical Notch ligand 1	Homo sapiens	133-137
21897005-1	2011	Prostate specific antigen (PSA) exhibits pronounced heterogeneity in both primary structure and glycan composition, resulting in the existence of different molecular forms.	Polysaccharides	96-102	kallikrein related peptidase 3	Homo sapiens	0-31
20864568-7	2011	We found that random-coil or rigid alpha-helical linkers that permit separation of the two galectin-1 CRDs facilitated the formation of higher-order galectin multimers and that these galectins were more potent in binding to glycan ligands and cell surface glycoprotein receptors, as well as triggering T cell death, compared with native galectin-1 or a construct with a short rigid linker.	Polysaccharides	224-230	galectin 1	Homo sapiens	91-101
20864568-7	2011	We found that random-coil or rigid alpha-helical linkers that permit separation of the two galectin-1 CRDs facilitated the formation of higher-order galectin multimers and that these galectins were more potent in binding to glycan ligands and cell surface glycoprotein receptors, as well as triggering T cell death, compared with native galectin-1 or a construct with a short rigid linker.	Polysaccharides	224-230	galectin 1	Homo sapiens	337-347
20809699-0	2011	Characterized polysaccharides from black soybean induce granulocyte colony-stimulated factor gene expression in a phosphoinositide 3-kinase-dependent manner.	Polysaccharides	14-29	phosphatidylinositol 3-kinase, root isoform	Glycine max	114-139
20809699-4	2011	In the present study, effects of characterized polysaccharides from black soybean (PGM) on granulocyte colony-stimulated factor (G-CSF) production in human peripheral blood mononuclear cells (PBMC) were determined and their action mechanisms were examined.	Polysaccharides	47-62	phosphoglycerate mutase-like protein	Glycine max	83-86
21496386-0	2011	Toll-like receptor 4-dependent adjuvant activity of Kakkon-to extract exists in the high molecular weight polysaccharide fraction.	Polysaccharides	106-120	toll-like receptor 4	Mus musculus	0-20
21876827-1	2011	We have established high-throughput lectin-antibody ELISAs to measure different glycans on transferrin (Tf) in cerebrospinal fluid (CSF) using lectins and an anti-transferrin antibody (TfAb).	Polysaccharides	80-87	transferrin	Homo sapiens	91-102
20626930-13	2011	Taken together, the results support the promise of using STMP in situ cross-linking for long-term stabilization of polysaccharide electrospun fibres and the advantage of polysaccharide nanofibrous constructs for tissue engineering.	Polysaccharides	115-129	STEAP2 metalloreductase	Homo sapiens	57-61
22324412-7	2011	G. lucidum was also a slightly better producer of biomass and extracellular polysaccharides (28.16 g L-1 and 1.42 mg mL-1, respectively) than G. carnosum (23.68 g L-1 and 0.35 mg mL-1, respectively).	Polysaccharides	76-91	L1 cell adhesion molecule	Mus musculus	101-104
20870456-0	2011	Expression of active and inactive recombinant soluble trehalase using baculovirus-silkworm expression system and their glycan structures.	Polysaccharides	119-125	trehalase	Bombyx mori	54-63
21176128-0	2010	Polysaccharides from the root of Angelica sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway.	Polysaccharides	0-15	thymoma viral proto-oncogene 1	Mus musculus	110-113
21858152-3	2011	We measured the oligomannose content of virion-associated gp120 from primary virus from PBMCs for a range of viral isolates and showed cross-clade elevation (62-79%) of these glycans relative to recombinant, monomeric gp120 (~30%).	Polysaccharides	175-182	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	58-63
21698274-0	2011	Astragalus polysaccharides attenuate postburn sepsis via inhibiting negative immunoregulation of CD4+ CD25(high) T cells.	Polysaccharides	11-26	CD4 antigen	Mus musculus	97-100
21698274-0	2011	Astragalus polysaccharides attenuate postburn sepsis via inhibiting negative immunoregulation of CD4+ CD25(high) T cells.	Polysaccharides	11-26	interleukin 2 receptor, alpha chain	Mus musculus	102-106
25309039-5	2011	Now the ENGase-based chemoenzymatic method has been extended to the synthesis of a range of complex carbohydrates, including homogeneous glycopeptides, glycoproteins carrying well-defined glycans, novel oligosaccharide clusters, unusually glycosylated natural products, and even polysaccharides.	Polysaccharides	188-195	endo-beta-N-acetylglucosaminidase	Homo sapiens	8-14
25309039-5	2011	Now the ENGase-based chemoenzymatic method has been extended to the synthesis of a range of complex carbohydrates, including homogeneous glycopeptides, glycoproteins carrying well-defined glycans, novel oligosaccharide clusters, unusually glycosylated natural products, and even polysaccharides.	Polysaccharides	279-294	endo-beta-N-acetylglucosaminidase	Homo sapiens	8-14
21850265-6	2011	Our goal was to identify glycans that are unique for hNP cells and use the corresponding lectins for cell isolation.	Polysaccharides	25-32	kallikrein related peptidase 8	Homo sapiens	53-56
21695217-2	2011	CAH1 is post-translationally modified at several residues by the attachment of N-glycans, resulting in a mature protein harbouring complex-type glycans.	Polysaccharides	81-88	alpha carbonic anhydrase 1	Arabidopsis thaliana	0-4
21187330-4	2010	Nesd contains a pectin lyase-like domain found in proteins that bind to polysaccharides, and we present evidence that it has high affinity for beta-galactosides in vitro.	Polysaccharides	72-87	nessun dorma	Drosophila melanogaster	0-4
20719493-7	2010	In the second approach, dextran sulfate and fucoidan were used as sensor coatings exploiting the fact that HGF binds specifically to those sulfated polysaccharides.	Polysaccharides	148-163	hepatocyte growth factor	Homo sapiens	107-110
21172065-5	2010	METHODS: N-Glycanase digestion from Flavobacterium meningosepticum (PNGase F) was performed on both native and denatured purified ACT condition and resolved to Western blot with the purpose to revealed the ACT de-glycosylation pattern.Further characterization of the ACT glycan profile was obtained by a glycoarray; each lectin group in the assay specifically recognizes one or two glycans/epitopes.	Polysaccharides	271-277	serpin family A member 3	Homo sapiens	206-209
21172065-5	2010	METHODS: N-Glycanase digestion from Flavobacterium meningosepticum (PNGase F) was performed on both native and denatured purified ACT condition and resolved to Western blot with the purpose to revealed the ACT de-glycosylation pattern.Further characterization of the ACT glycan profile was obtained by a glycoarray; each lectin group in the assay specifically recognizes one or two glycans/epitopes.	Polysaccharides	271-277	serpin family A member 3	Homo sapiens	206-209
21172065-5	2010	METHODS: N-Glycanase digestion from Flavobacterium meningosepticum (PNGase F) was performed on both native and denatured purified ACT condition and resolved to Western blot with the purpose to revealed the ACT de-glycosylation pattern.Further characterization of the ACT glycan profile was obtained by a glycoarray; each lectin group in the assay specifically recognizes one or two glycans/epitopes.	Polysaccharides	382-389	serpin family A member 3	Homo sapiens	206-209
21172065-5	2010	METHODS: N-Glycanase digestion from Flavobacterium meningosepticum (PNGase F) was performed on both native and denatured purified ACT condition and resolved to Western blot with the purpose to revealed the ACT de-glycosylation pattern.Further characterization of the ACT glycan profile was obtained by a glycoarray; each lectin group in the assay specifically recognizes one or two glycans/epitopes.	Polysaccharides	382-389	serpin family A member 3	Homo sapiens	206-209
20858220-5	2010	Gal-8 bound specific glycans in the platelet membrane and triggered spreading, calcium mobilization and fibrinogen binding.	Polysaccharides	21-28	galectin 8	Homo sapiens	0-5
20861015-2	2010	Initial folding of the heavy chain involves its glycan-dependent association with calreticulin (CRT), calnexin (CNX), and the thiol oxidoreductase ERp57, and is followed by assembly with beta(2)m to form the heterodimer.	Polysaccharides	48-54	calreticulin	Homo sapiens	82-94
21056543-0	2010	Further insight into the roles of the glycans attached to human blood protein C inhibitor.	Polysaccharides	38-45	serpin family A member 5	Homo sapiens	70-89
21078982-8	2010	These results demonstrate that GnT-V expression and its branched glycan products effectively modulate her-2-mediated signaling pathways that, in turn, regulate the relative proportion of tumor initiating cells and the latency of her-2-driven tumor onset.	Polysaccharides	65-71	erb-b2 receptor tyrosine kinase 2	Mus musculus	102-107
21055951-7	2010	Collectively, we have demonstrated that the polysaccharide fraction of G. lucidum F3 exhibits cytokine and chemokine like functions which are beneficial to human tissue stem/progenitor cells by modulating their CAM expressions and biological activities.	Polysaccharides	44-58	neural cell adhesion molecule 1	Homo sapiens	211-214
20937802-3	2010	Short term prevention of glycan-calnexin interactions by castanospermine slightly increases ER retention of beta(1), suggesting minor involvement of calnexin in subunit folding.	Polysaccharides	25-31	calnexin	Canis lupus familiaris	32-40
20937802-5	2010	In contrast to beta(1), prevention of either N-glycosylation or glycan-calnexin interactions abolishes the alpha(1)-assembly and export of beta(2) from the ER despite increased beta(2)-BiP binding.	Polysaccharides	64-70	calnexin	Canis lupus familiaris	71-79
20861015-2	2010	Initial folding of the heavy chain involves its glycan-dependent association with calreticulin (CRT), calnexin (CNX), and the thiol oxidoreductase ERp57, and is followed by assembly with beta(2)m to form the heterodimer.	Polysaccharides	48-54	calreticulin	Homo sapiens	96-99
20861015-2	2010	Initial folding of the heavy chain involves its glycan-dependent association with calreticulin (CRT), calnexin (CNX), and the thiol oxidoreductase ERp57, and is followed by assembly with beta(2)m to form the heterodimer.	Polysaccharides	48-54	calnexin	Homo sapiens	102-110
20861015-2	2010	Initial folding of the heavy chain involves its glycan-dependent association with calreticulin (CRT), calnexin (CNX), and the thiol oxidoreductase ERp57, and is followed by assembly with beta(2)m to form the heterodimer.	Polysaccharides	48-54	calnexin	Homo sapiens	112-115
20861015-2	2010	Initial folding of the heavy chain involves its glycan-dependent association with calreticulin (CRT), calnexin (CNX), and the thiol oxidoreductase ERp57, and is followed by assembly with beta(2)m to form the heterodimer.	Polysaccharides	48-54	protein disulfide isomerase family A member 3	Homo sapiens	147-152
20861015-2	2010	Initial folding of the heavy chain involves its glycan-dependent association with calreticulin (CRT), calnexin (CNX), and the thiol oxidoreductase ERp57, and is followed by assembly with beta(2)m to form the heterodimer.	Polysaccharides	48-54	beta-2-microglobulin	Homo sapiens	187-195
20490888-8	2010	E-selectin overexpressed and was correlated with galactose-containing glycans in RA synovial tissue.	Polysaccharides	70-77	selectin E	Homo sapiens	0-10
21070288-1	2010	The GYS1 gene mutation that is causative of Type 1 Polysaccharide Storage Myopathy (PSSM) has been identified in more than 20 breeds of horses.	Polysaccharides	51-65	glycogen synthase 1	Equus caballus	4-8
21087091-3	2010	Changes in haptoglobin glycan structure were observed in several diseases.	Polysaccharides	23-29	haptoglobin	Homo sapiens	11-22
21087091-4	2010	The aim of this study was to investigate whether haptoglobin displays glycan variations in psoriasis.	Polysaccharides	70-76	haptoglobin	Homo sapiens	49-60
21087091-9	2010	Abundance or structure of specific glycans, which are present in haptoglobin from patients and are different or missing in normal haptoglobin, might be associated with disease activity.	Polysaccharides	35-42	haptoglobin	Homo sapiens	65-76
21087091-9	2010	Abundance or structure of specific glycans, which are present in haptoglobin from patients and are different or missing in normal haptoglobin, might be associated with disease activity.	Polysaccharides	35-42	haptoglobin	Homo sapiens	130-141
20624446-1	2010	The polysaccharide (PAP) from Potentilla anserina was evaluated for modulating effects by using mouse peritoneal macrophage and the immunosuppressed-model cyclophosphamide-induced.	Polysaccharides	4-18	phospholipid phosphatase 1	Mus musculus	20-23
21151985-6	2010	DNA microarray analysis indicated that the Ecs deficiency changed expression of the virulence factor regulator protein Rot accompanied by differential expression of membrane transport proteins, particularly ABC transporters and phosphate-specific transport systems, protein A, adhesins and capsular polysaccharide biosynthesis proteins.	Polysaccharides	299-313	epistatic circling SWR/J	Mus musculus	43-46
20800276-7	2010	Osteoblast attachment, as well as alkaline phosphatase (ALP) activity and calcium deposition were enhanced by the immobilized VEGF on the polysaccharide-grafted Ti.	Polysaccharides	138-152	AT695_RS04080	Staphylococcus aureus	34-54
20800276-7	2010	Osteoblast attachment, as well as alkaline phosphatase (ALP) activity and calcium deposition were enhanced by the immobilized VEGF on the polysaccharide-grafted Ti.	Polysaccharides	138-152	AT695_RS04080	Staphylococcus aureus	56-59
21478110-6	2010	In the young patients, expression of polysaccharides correlated with inflammatory activity (grading), width of gallbladder wall and PLT level in peripheral blood.	Polysaccharides	37-52	N-acylethanolamine acid amidase	Homo sapiens	132-135
20976527-1	2010	The identification of glycan epitopes such as the histo-blood group ABH determinants as docking sites for bacterial/viral infections and signals in growth regulation fuels the interest to develop non-hydrolysable mimetics for therapeutic applications.	Polysaccharides	22-28	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	68-71
21053369-0	2010	Glycosylation analysis of interleukin-23 receptor: elucidation of glycosylation sites and characterization of attached glycan structures.	Polysaccharides	119-125	interleukin 23 receptor	Homo sapiens	26-49
20974960-3	2010	Analysis of the 2,214,650-bp genome of Bifidobacterium bifidum PRL2010, a strain isolated from infant stool, revealed a nutrient-acquisition strategy that targets host-derived glycans, such as those present in mucin.	Polysaccharides	176-183	LOC100508689	Homo sapiens	210-215
21143682-1	2010	Several proteins encoded by the cellulose synthase-like (CSL) gene family are known to be processive glycan synthases involved in the synthesis of cell-wall polysaccharides.	Polysaccharides	157-172	cellulose synthase like	Arabidopsis thaliana	32-55
21143682-1	2010	Several proteins encoded by the cellulose synthase-like (CSL) gene family are known to be processive glycan synthases involved in the synthesis of cell-wall polysaccharides.	Polysaccharides	157-172	cellulose synthase like	Arabidopsis thaliana	57-60
21548372-6	2010	The Astragalus polysaccharide group could improve erythrocyte immune function and increase the CD35 and CD44s contents of red blood cells.	Polysaccharides	15-29	CD44 molecule (Indian blood group)	Rattus norvegicus	104-108
20688960-3	2010	We further demonstrated that the Leu67/His67 substitution is critical for the decrease in glycan binding of CXCL4L1 but also for the increase of its angiostatic activities.	Polysaccharides	90-96	platelet factor 4 variant 1	Homo sapiens	108-115
20638358-6	2010	Subsequent surface plasmon resonance experiments using a reverse setup with immobilization of the BACH-glycan ligands on streptavidin-coated surfaces provide more information on glycan-CBP interactions via association and dissociation curves.	Polysaccharides	103-109	CREB binding protein	Homo sapiens	185-188
21262610-0	2010	Presence of the glycogen synthase 1 (GYS1) mutation causing type 1 polysaccharide storage myopathy in continental European draught horse breeds.	Polysaccharides	67-81	glycogen synthase 1	Equus caballus	16-35
21262610-0	2010	Presence of the glycogen synthase 1 (GYS1) mutation causing type 1 polysaccharide storage myopathy in continental European draught horse breeds.	Polysaccharides	67-81	glycogen synthase 1	Equus caballus	37-41
21262610-1	2010	The purpose of this study was to determine which continental European draught horse breeds harbour a mutation in the glycogen synthase 1 gene (GYS1) that is known to be responsible for type 1 polysaccharide storage myopathy in quarter horses and North American draught horses.	Polysaccharides	192-206	glycogen synthase 1	Equus caballus	117-136
21262610-1	2010	The purpose of this study was to determine which continental European draught horse breeds harbour a mutation in the glycogen synthase 1 gene (GYS1) that is known to be responsible for type 1 polysaccharide storage myopathy in quarter horses and North American draught horses.	Polysaccharides	192-206	glycogen synthase 1	Equus caballus	143-147
20739279-10	2010	The modification of SynCAM 1 with sialic acids contributes to the glycan-dependent strengthening of its binding.	Polysaccharides	66-72	cell adhesion molecule 1	Homo sapiens	20-28
20800830-2	2010	RESULTS: (1) The serous acini in the submucosal glands from the larynx and the soft palate expressed MUC1-associated glycans that were not detectable in the serous acini from the submandibular gland.	Polysaccharides	117-124	mucin 1, cell surface associated	Homo sapiens	101-105
20807768-3	2010	We have now produced 10 mutants of human galectin-3, with changes in these adjacent sites that have altered carbohydrate-binding fine specificity but that retain the basic beta-galactoside binding activity as shown by glycan-array binding and a solution-based fluorescence anisotropy assay.	Polysaccharides	218-224	galectin 3	Homo sapiens	41-51
20807768-5	2010	Galectin-3 R186S, which has selectively lost affinity for LacNAc, a disaccharide moiety commonly found on glycoprotein glycans, has lost the ability to activate neutrophil leukocytes and intracellular targeting into vesicles.	Polysaccharides	119-126	galectin 3	Homo sapiens	0-10
21254594-5	2010	It was concluded that the model of selective liver macrophagedepression is useful for studying the protective effects of biological response modifiers such as polysaccharides (beta-1,3-glucans) in vivo.	Polysaccharides	159-174	hemoglobin, beta adult major chain	Mus musculus	176-184
20815703-4	2010	METHODS: We developed an HBGA blocking assay to examine the ability of human serum to block the interaction of NV viruslike particles with H type 1 and H type 3 glycans.	Polysaccharides	161-168	hemoglobin subunit gamma 1	Homo sapiens	25-29
20688784-5	2010	To understand the mechanisms and consequences of tissue-specific glycan expression, we identified a single alpha3-fucosyltransferase (FucTA) that produces the anti-HRP epitope in Drosophila embryos.	Polysaccharides	65-71	alpha1,3-fucosyltransferase A	Drosophila melanogaster	107-132
20688784-5	2010	To understand the mechanisms and consequences of tissue-specific glycan expression, we identified a single alpha3-fucosyltransferase (FucTA) that produces the anti-HRP epitope in Drosophila embryos.	Polysaccharides	65-71	alpha1,3-fucosyltransferase A	Drosophila melanogaster	134-139
20688784-8	2010	Mass spectrometric characterization of the N-glycans of Drosophila embryos overexpressing FucTA confirms that this enzyme is indeed responsible for the biosynthesis of difucosylated glycans in vivo.	Polysaccharides	45-52	alpha1,3-fucosyltransferase A	Drosophila melanogaster	90-95
20634764-1	2010	Amyloidosis is a multisystem disease characterized by extracellular deposition of complex protein-polysaccharide in a beta-pleated configuration.	Polysaccharides	98-112	amyloid beta precursor protein	Homo sapiens	116-122
20811656-6	2010	Treatment and even prevention of diabetes and metabolic syndrome will benefit from a more complete elucidation of cellular-signaling events activated by insulin, to include the actions of second messengers such as glycan molecules that contain D-chiro-inositol (DCI).	Polysaccharides	214-220	insulin	Homo sapiens	153-160
21921530-0	2010	[Glycan biomaker in CSF].	Polysaccharides	1-7	colony stimulating factor 2	Homo sapiens	20-23
21328972-12	2010	(2) New Compound Codonopsis Pilosula (NCCP), Xiang Qi Polysaccharide (XQP) and NCCP + XQP could significantly increase the number of peripheral blood CD3+, CD4+ and spleen CD4+, but had no significant influence on the number of spleen CD8+.	Polysaccharides	54-68	CD3 antigen, epsilon polypeptide	Mus musculus	150-153
21328972-12	2010	(2) New Compound Codonopsis Pilosula (NCCP), Xiang Qi Polysaccharide (XQP) and NCCP + XQP could significantly increase the number of peripheral blood CD3+, CD4+ and spleen CD4+, but had no significant influence on the number of spleen CD8+.	Polysaccharides	54-68	CD4 antigen	Mus musculus	156-159
21328972-12	2010	(2) New Compound Codonopsis Pilosula (NCCP), Xiang Qi Polysaccharide (XQP) and NCCP + XQP could significantly increase the number of peripheral blood CD3+, CD4+ and spleen CD4+, but had no significant influence on the number of spleen CD8+.	Polysaccharides	54-68	CD4 antigen	Mus musculus	172-175
21049021-0	2010	The human host defense peptide LL-37 interacts with Neisseria meningitidis capsular polysaccharides and inhibits inflammatory mediators release.	Polysaccharides	84-99	cathelicidin antimicrobial peptide	Homo sapiens	31-36
20800070-3	2010	Molecular models revealed a significant difference in gp120 glycan coverage between the Sf9-derived and wild-type mammalian-cell-derived material that is predicted to affect ligand binding sites proximal to glycans.	Polysaccharides	60-66	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	54-59
20800070-3	2010	Molecular models revealed a significant difference in gp120 glycan coverage between the Sf9-derived and wild-type mammalian-cell-derived material that is predicted to affect ligand binding sites proximal to glycans.	Polysaccharides	207-214	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	54-59
20842142-2	2010	This effect is brought about by its specific binding to Man-alpha(1-2)-Man unit(s) of high-mannose type glycan (HMTG) bound to HIV gp120.	Polysaccharides	104-110	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	131-136
21170871-3	2010	In addition to in the distal nephron where it is abundantly expressed, Klotho is present in the proximal tubule lumen where it inhibits renal Pi excretion by modulating Na-coupled Pi transporters via enzymatic glycan modification of the transporter proteins - an effect completely independent of its role as the FGF23 coreceptor.	Polysaccharides	210-216	klotho	Homo sapiens	71-77
20844034-7	2010	Furthermore, our data demonstrate that at least five glycans on E2 (denoted E2N1, E2N2, E2N4, E2N6, and E2N11) strongly reduce the sensitivity of HCVcc to antibody neutralization, with four of them surrounding the CD81 binding site.	Polysaccharides	53-60	small nucleolar RNA, C/D box 12C	Homo sapiens	64-66
20844034-7	2010	Furthermore, our data demonstrate that at least five glycans on E2 (denoted E2N1, E2N2, E2N4, E2N6, and E2N11) strongly reduce the sensitivity of HCVcc to antibody neutralization, with four of them surrounding the CD81 binding site.	Polysaccharides	53-60	small nucleolar RNA, C/D box 12C	Homo sapiens	76-80
20807862-8	2010	Since MYB75 physically interacts with another secondary cell wall regulator, the KNOX transcription factor KNAT7, these regulatory proteins may form functional complexes that contribute to the regulation of secondary cell wall deposition in the Arabidopsis inflorescence stem and that integrate the metabolic flux through the lignin, flavonoid, and polysaccharide pathways.	Polysaccharides	349-363	production of anthocyanin pigment 1	Arabidopsis thaliana	6-11
20807862-8	2010	Since MYB75 physically interacts with another secondary cell wall regulator, the KNOX transcription factor KNAT7, these regulatory proteins may form functional complexes that contribute to the regulation of secondary cell wall deposition in the Arabidopsis inflorescence stem and that integrate the metabolic flux through the lignin, flavonoid, and polysaccharide pathways.	Polysaccharides	349-363	homeobox knotted-like protein	Arabidopsis thaliana	107-112
20729207-4	2010	The use of a synthetic glycan and of the lipid moiety cleaved from the GPIs shows that both parts are involved in the interaction with galectin-3.	Polysaccharides	23-29	galectin 3	Homo sapiens	135-145
20855873-8	2010	Furthermore, this fragment of CRT exhibits strong adjuvanticity when conjugated to polysaccharides or expressed as part of a fusion protein.	Polysaccharides	83-98	calreticulin	Mus musculus	30-33
20800224-2	2010	There is little information available about complex glycans on NGAL.	Polysaccharides	52-59	lipocalin 2	Homo sapiens	63-67
20795698-12	2010	When the polysaccharide-based PEMs were formed on titanium, the proliferative response of ovine MSCs to adsorbed FGF-2 was not as strong as the response to FGF-2 delivered in solution.	Polysaccharides	9-23	fibroblast growth factor 2	Homo sapiens	113-118
20800224-6	2010	Six different mutant recombinant NGAL samples (samples A-F) were analyzed in this study; however, these samples demonstrated two different glycan patterns.	Polysaccharides	139-145	lipocalin 2	Homo sapiens	33-37
20570965-3	2010	High expression levels of the ubiquitous Golgi protein estrogen receptor-binding fragment-associated gene 9 (EBAG9) in human tumors correlate with poor clinical prognosis, and EBAG9 overexpression in epithelial cell lines induces truncated glycans, typical of many carcinomas.	Polysaccharides	240-247	estrogen receptor binding site associated antigen 9	Homo sapiens	55-107
20711574-6	2010	Moreover, this system was capable of attaching sialic acids to the glycans of asialofetuin via alpha(2,3)- or alpha(2,6)-linkage.	Polysaccharides	67-74	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	95-104
20711574-6	2010	Moreover, this system was capable of attaching sialic acids to the glycans of asialofetuin via alpha(2,3)- or alpha(2,6)-linkage.	Polysaccharides	67-74	homeodomain mating type protein alpha2	Saccharomyces cerevisiae S288C	110-119
20621206-4	2010	MPO has 5 N-linked glycosylation sites, occupied by both high mannose and complex glycan structures.	Polysaccharides	82-88	myeloperoxidase	Homo sapiens	0-3
20621206-5	2010	In this study we utilize intact glycopeptide MSMS analysis for site specific characterization of the glycan structures of MPO from a cancer patient.	Polysaccharides	101-107	myeloperoxidase	Homo sapiens	122-125
20726535-2	2010	We demonstrate that monoclonal antibodies against interleukin-1beta and tumor necrosis factor-alpha were still active when conjugated to high molecular weight polysaccharides.	Polysaccharides	159-174	interleukin 1 beta	Homo sapiens	50-99
20726535-4	2010	To explore this new class of protein-polysaccharide conjugates, we covalently modified interleukin-1beta and tumor necrosis factor-alpha monoclonal antibodies with high molecular weight hyaluronic acid and carboxymethylcellulose.	Polysaccharides	37-51	interleukin 1 beta	Homo sapiens	87-136
20863315-0	2010	Ionic liquids in oligosaccharide synthesis: towards mucin-type glycan probes.	Polysaccharides	63-69	LOC100508689	Homo sapiens	52-57
20570965-3	2010	High expression levels of the ubiquitous Golgi protein estrogen receptor-binding fragment-associated gene 9 (EBAG9) in human tumors correlate with poor clinical prognosis, and EBAG9 overexpression in epithelial cell lines induces truncated glycans, typical of many carcinomas.	Polysaccharides	240-247	estrogen receptor binding site associated antigen 9	Homo sapiens	109-114
20692269-2	2010	Here, we provide evidence that, unlike other C-type lectins, human RegIV binds to polysaccharides, mannan, and heparin in the absence of calcium.	Polysaccharides	82-97	regenerating family member 4	Homo sapiens	67-72
20554947-7	2010	Unexpectedly, when the 2-O-sulfotransferase was co-immunoprecipitated with the glucuronyl C5-epimerase (that converts glucuronic acid to iduronic acid), both glucuronic acid and iduronic acid residues were sulfated to the same extent when a polysaccharide containing only glucuronic acid was used as a substrate.	Polysaccharides	241-255	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	23-43
20554947-7	2010	Unexpectedly, when the 2-O-sulfotransferase was co-immunoprecipitated with the glucuronyl C5-epimerase (that converts glucuronic acid to iduronic acid), both glucuronic acid and iduronic acid residues were sulfated to the same extent when a polysaccharide containing only glucuronic acid was used as a substrate.	Polysaccharides	241-255	glucuronic acid epimerase	Homo sapiens	79-102
20621666-2	2010	A water-soluble polysaccharide with a molar weight of 4.3x10(5)Da, termed as HBP was isolated from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.)	Polysaccharides	16-30	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	Mus musculus	77-80
20534593-3	2010	The sialyltransferase ST3Gal-I adds sialic acid to the galactose residue of core 1 (Galbeta1,3GalNAc) O-glycans and this enzyme is over-expressed in breast cancer resulting in the expression of sialylated core 1 glycans.	Polysaccharides	104-111	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Mus musculus	22-30
21637578-1	2010	UDP-glucose dehydrogenase (UGDH) catalyzes the oxidation of UDP-glucose (UDP-Glc) to UDP-glucuronate (UDP-GlcA), a key sugar nucleotide involved in the biosynthesis of plant cell wall polysaccharides.	Polysaccharides	184-199	UDP-glucose 6-dehydrogenase 1	Eucalyptus grandis	0-25
21637578-1	2010	UDP-glucose dehydrogenase (UGDH) catalyzes the oxidation of UDP-glucose (UDP-Glc) to UDP-glucuronate (UDP-GlcA), a key sugar nucleotide involved in the biosynthesis of plant cell wall polysaccharides.	Polysaccharides	184-199	UDP-glucose 6-dehydrogenase 1	Eucalyptus grandis	27-31
19897529-0	2010	Interleukin-6 is essential for zwitterionic polysaccharide-mediated abscess formation.	Polysaccharides	44-58	interleukin 6	Mus musculus	0-13
19897529-9	2010	The data delineate the essential role of IL-6 in the linkage of innate and adaptive immunity in polysaccharide-mediated abscess formation.	Polysaccharides	96-110	interleukin 6	Mus musculus	41-45
20660042-1	2010	CONTEXT: Human chorionic gonadotropin (hCG) is the major pregnancy glycoprotein hormone whose maternal concentration and glycan structure change all along pregnancy.	Polysaccharides	121-127	hypertrichosis 2 (generalised, congenital)	Homo sapiens	39-42
20936123-6	2010	Each of the glycosylation sites observed was shown to be modified with a heterogeneous family of glycans, with the largest having a composition Glc(1)Man(2)GlcNAc(2) plus 6-sulfoquinovose (QuiS), consistent with the tribranched hexasaccharide previously reported in the cytochrome b(558/566) of S. acidocaldarius.	Polysaccharides	97-104	mitochondrially encoded cytochrome b	Homo sapiens	270-282
20660596-5	2010	We have shown previously that this coding change (Y402H; from a tyrosine to histidine residue) alters the binding of the CFH protein to sulfated polysaccharides.	Polysaccharides	145-160	complement factor H	Homo sapiens	121-124
20948901-3	2010	The enzymatic hydrolysis of the macroaggregate matrix, using alpha-amylase, beta-glucosidase, protease, proteinase and lipase, revealed the simultaneous degradation of polysaccharides and proteins, while lipids seem largely preserved.	Polysaccharides	168-183	endogenous retrovirus group K member 25	Homo sapiens	104-114
20885963-4	2010	Here we show that natural muscle-specific coatings can (i) be derived from decellularized, solubilized adult porcine muscle, (ii) contain a complex mixture of ECM components including polysaccharides, (iii) adsorb onto tissue culture plastic and (iv) promote cell maturation of committed muscle progenitor and stem cells.	Polysaccharides	184-199	eukaryotic translation initiation factor 3 subunit K	Homo sapiens	26-41
20824073-0	2010	Ctr2 links copper homeostasis to polysaccharide capsule formation and phagocytosis inhibition in the human fungal pathogen Cryptococcus neoformans.	Polysaccharides	33-47	solute carrier family 31 member 2	Homo sapiens	0-4
18955322-0	2010	Hochuekkito, a Kampo (Traditional Japanese Herbal) Medicine, and its Polysaccharide Portion Stimulate G-CSF Secretion from Intestinal Epithelial Cells.	Polysaccharides	69-83	colony stimulating factor 3 (granulocyte)	Mus musculus	102-107
20646933-5	2010	Ulinastatin treatment significantly decreased the zymosan-induced elevation in serum concentrations of TNF-alpha and sICAM-1 and tissue abundance of TLR mRNA in the liver, kidney and lung, effectively attenuated the development of the polysaccharide-induced biochemical and histological abnormalities and successfully reduced the MODS-associated death.	Polysaccharides	235-249	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	0-11
20646933-6	2010	In conclusion, ulinastatin is able to protect multiple organs from yeast polysaccharide-induced damage and function failure, at least partially, through a TLR4-dependent mechanism, suggesting a therapeutic potential against MODS.	Polysaccharides	73-87	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	15-26
20646933-6	2010	In conclusion, ulinastatin is able to protect multiple organs from yeast polysaccharide-induced damage and function failure, at least partially, through a TLR4-dependent mechanism, suggesting a therapeutic potential against MODS.	Polysaccharides	73-87	toll-like receptor 4	Rattus norvegicus	155-159
18955322-8	2010	When the HET was fractionated, only the polysaccharide fraction (F-5) enhanced the G-CSF secretion of MCE301 cells, and the activity of F-5 lost after the treatment of periodate that can degrade the carbohydrate moiety.	Polysaccharides	40-54	coagulation factor V	Mus musculus	65-68
18955322-8	2010	When the HET was fractionated, only the polysaccharide fraction (F-5) enhanced the G-CSF secretion of MCE301 cells, and the activity of F-5 lost after the treatment of periodate that can degrade the carbohydrate moiety.	Polysaccharides	40-54	colony stimulating factor 3 (granulocyte)	Mus musculus	83-88
20506485-4	2010	Here, we show that si-RNA induced down-regulation of the expression of FUT1 and FUT2, the fucosyltransferases required for the biosynthesis of the terminal glycan motif Fucalpha-2-Galbeta-R, reduced expression of the fucosylated nucleolin glycoforms and their exposure at the cell surface in CVEC.	Polysaccharides	156-162	fucosyltransferase 1 (H blood group)	Homo sapiens	71-75
20466874-8	2010	Klotho is a novel phosphaturic substance that acts as an enzyme in the proximal tubule urinary lumen by modifying glycans, which cause decreased transporter activity, followed by proteolytic degradation and possibly internalization of NaPi-2a from the apical membrane.	Polysaccharides	114-121	klotho	Mus musculus	0-6
20506485-4	2010	Here, we show that si-RNA induced down-regulation of the expression of FUT1 and FUT2, the fucosyltransferases required for the biosynthesis of the terminal glycan motif Fucalpha-2-Galbeta-R, reduced expression of the fucosylated nucleolin glycoforms and their exposure at the cell surface in CVEC.	Polysaccharides	156-162	fucosyltransferase 2	Homo sapiens	80-84
20506485-4	2010	Here, we show that si-RNA induced down-regulation of the expression of FUT1 and FUT2, the fucosyltransferases required for the biosynthesis of the terminal glycan motif Fucalpha-2-Galbeta-R, reduced expression of the fucosylated nucleolin glycoforms and their exposure at the cell surface in CVEC.	Polysaccharides	156-162	nucleolin	Homo sapiens	229-238
20511397-3	2010	Some of the glycan structures on plasma apoE are characterized; however, the more complicated structures on plasma and cellular/secreted apoE remain unidentified.	Polysaccharides	12-18	apolipoprotein E	Homo sapiens	40-44
20723671-6	2010	A highly significant inverse correlation was found between capsule polysaccharide levels of bacterial strains and their lethality in the presence of different concentrations of amidated lactoferrin.	Polysaccharides	67-81	lactotransferrin	Bos taurus	186-197
20610714-0	2010	HIV-1 gp120 determinants proximal to the CD4 binding site shift protective glycans that are targeted by monoclonal antibody 2G12.	Polysaccharides	75-82	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	6-11
20610714-0	2010	HIV-1 gp120 determinants proximal to the CD4 binding site shift protective glycans that are targeted by monoclonal antibody 2G12.	Polysaccharides	75-82	CD4 molecule	Homo sapiens	41-44
20511397-5	2010	Our results identify eight different glycoforms with (HexNAc)(2)-Hex(2)-(NeuAc)(2) being the most complex glycan detected on Thr(194) in both cellular and secreted apoE.	Polysaccharides	106-112	apolipoprotein E	Homo sapiens	164-168
20511397-6	2010	Four additional glycans were identified on apoE(283-299), and using beta-elimination/alkylation by methylamine in vitro, we identified Ser(290) as a novel site of glycan attachment.	Polysaccharides	16-23	apolipoprotein E	Homo sapiens	43-47
20511397-6	2010	Four additional glycans were identified on apoE(283-299), and using beta-elimination/alkylation by methylamine in vitro, we identified Ser(290) as a novel site of glycan attachment.	Polysaccharides	16-22	apolipoprotein E	Homo sapiens	43-47
20662012-0	2010	Core glycan in the yeast multicopper ferroxidase, Fet3p: a case study of N-linked glycosylation, protein maturation, and stability.	Polysaccharides	5-11	ferroxidase	Saccharomyces cerevisiae S288C	37-48
20805402-5	2010	Recent investigations of the structure and function of ABC transporters involved in the export of lipopolysaccharide O antigens have revealed two fundamentally different strategies for coupling glycan polymerization to export.	Polysaccharides	194-200	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	55-58
20805402-7	2010	A bioinformatic survey examining ABC exporters from known oligo- and polysaccharide biosynthesis loci identifies conserved nucleotide-binding domain protein families that correlate well with themes in the structures and assembly of glycans.	Polysaccharides	69-83	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	33-36
20805402-7	2010	A bioinformatic survey examining ABC exporters from known oligo- and polysaccharide biosynthesis loci identifies conserved nucleotide-binding domain protein families that correlate well with themes in the structures and assembly of glycans.	Polysaccharides	232-239	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	33-36
20662012-0	2010	Core glycan in the yeast multicopper ferroxidase, Fet3p: a case study of N-linked glycosylation, protein maturation, and stability.	Polysaccharides	5-11	ferroxidase FET3	Saccharomyces cerevisiae S288C	50-55
20662012-3	2010	Fet3p has 11 crystallographically mapped N-linked core glycan units.	Polysaccharides	55-61	ferroxidase FET3	Saccharomyces cerevisiae S288C	0-5
20662012-5	2010	Fet3 protein lacking any one of these glycan units is found in an intracellular high-molecular mass species resolvable by blue native gel electrophoresis.	Polysaccharides	38-44	ferroxidase FET3	Saccharomyces cerevisiae S288C	0-4
20573065-5	2010	Enzymes involved in glycan processing such as mannosidase-II (Man-II) and N-acetylglucosamine transferase-I (GnT-I) redistributed to aberrant intracellular structures and to the cell surface in SAC1 knockdown cells.	Polysaccharides	20-26	mannosidase alpha class 2A member 1	Homo sapiens	46-60
20573065-5	2010	Enzymes involved in glycan processing such as mannosidase-II (Man-II) and N-acetylglucosamine transferase-I (GnT-I) redistributed to aberrant intracellular structures and to the cell surface in SAC1 knockdown cells.	Polysaccharides	20-26	mannosidase alpha class 2A member 1	Homo sapiens	62-68
20573065-5	2010	Enzymes involved in glycan processing such as mannosidase-II (Man-II) and N-acetylglucosamine transferase-I (GnT-I) redistributed to aberrant intracellular structures and to the cell surface in SAC1 knockdown cells.	Polysaccharides	20-26	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	109-114
20573065-5	2010	Enzymes involved in glycan processing such as mannosidase-II (Man-II) and N-acetylglucosamine transferase-I (GnT-I) redistributed to aberrant intracellular structures and to the cell surface in SAC1 knockdown cells.	Polysaccharides	20-26	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	194-198
20724661-0	2010	Insights into the mechanism of polysaccharide dephosphorylation by a glucan phosphatase.	Polysaccharides	31-45	EPM2A glucan phosphatase, laforin	Homo sapiens	69-87
20713592-7	2010	Knockdown of GnTV, an enzyme that synthesizes high-affinity glycan ligands for galectin-3, substantially reduced: (a) complex N-glycans on alphavbeta3 integrins and (b) VEGF- and bFGF-mediated angiogenesis.	Polysaccharides	60-66	galectin 3	Homo sapiens	79-89
20811639-4	2010	METHODOLOGY/PRINCIPAL FINDINGS: Patients with liver cirrhosis and liver cancer had increased levels of triantennary glycan-containing outer arm (alpha-1,3) fucosylation.	Polysaccharides	116-122	adrenoceptor alpha 1D	Homo sapiens	145-154
20656349-1	2010	BACKGROUND: Galectin-1 (gal-1), a member of the mammalian beta-galactoside-binding proteins, exerts biological effects by recognition of glycan ligands, including those involved in cell adhesion and growth regulation.	Polysaccharides	137-143	galectin 1	Homo sapiens	12-22
20656349-1	2010	BACKGROUND: Galectin-1 (gal-1), a member of the mammalian beta-galactoside-binding proteins, exerts biological effects by recognition of glycan ligands, including those involved in cell adhesion and growth regulation.	Polysaccharides	137-143	galectin 1	Homo sapiens	24-29
20616231-5	2010	A shift from the CD4-defined orientation, however, focuses VRC01 onto the vulnerable site of initial CD4 attachment, allowing it to overcome the glycan and conformational masking that diminishes the neutralization potency of most CD4-binding-site antibodies.	Polysaccharides	145-151	CD4 molecule	Homo sapiens	17-20
20669970-5	2010	The inhibition is highly dependent on the structure and density of the glycans; selective inhibition of Stx1 and the more clinically relevant Stx2 was achieved.	Polysaccharides	71-78	syntaxin-2	Chlorocebus sabaeus	142-146
20669970-7	2010	Our results suggest that tailored glyconanoparticles that mimic the natural display of glycans in lipid rafts could serve as potential therapeutics for Stx1 and Stx2.	Polysaccharides	87-94	syntaxin-2	Chlorocebus sabaeus	161-165
20709295-0	2010	Direct complement restriction of flavivirus infection requires glycan recognition by mannose-binding lectin.	Polysaccharides	63-69	mannose binding lectin 2	Homo sapiens	85-107
20616231-5	2010	A shift from the CD4-defined orientation, however, focuses VRC01 onto the vulnerable site of initial CD4 attachment, allowing it to overcome the glycan and conformational masking that diminishes the neutralization potency of most CD4-binding-site antibodies.	Polysaccharides	145-151	CD4 molecule	Homo sapiens	101-104
20616231-5	2010	A shift from the CD4-defined orientation, however, focuses VRC01 onto the vulnerable site of initial CD4 attachment, allowing it to overcome the glycan and conformational masking that diminishes the neutralization potency of most CD4-binding-site antibodies.	Polysaccharides	145-151	CD4 molecule	Homo sapiens	101-104
20483383-0	2010	Water-soluble polysaccharide obtained from Acorus calamus L. classically activates macrophages and stimulates Th1 response.	Polysaccharides	14-28	negative elongation factor complex member C/D, Th1l	Mus musculus	110-113
20681640-0	2010	Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine macrophages and T lymphocytes.	Polysaccharides	0-15	pregnancy specific glycoprotein 16	Mus musculus	16-20
20416371-6	2010	The core (polysaccharide containing) region of LPS had a greater inhibitory effect on Trx-1 activity than its Lipid A fragment, suggesting the involvement of sugar groups.	Polysaccharides	10-24	thioredoxin	Homo sapiens	86-91
20643940-2	2010	However, despite extensive research revealing essential functional roles in infection and immune evasion, the chemical structures of the glycans on the native viral envelope glycoprotein gp120--as opposed to recombinantly generated gp120--have not been described.	Polysaccharides	137-144	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	187-192
20643940-5	2010	In stark contrast to recombinant gp120, which shows extensive exposure to cellular glycosylation enzymes (&gt;70% complex type glycans), the native envelope shows barely detectable processing beyond the biosynthetic intermediate Man5GlcNAc2 (&lt;2% complex type glycans).	Polysaccharides	127-134	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	33-38
20643940-5	2010	In stark contrast to recombinant gp120, which shows extensive exposure to cellular glycosylation enzymes (&gt;70% complex type glycans), the native envelope shows barely detectable processing beyond the biosynthetic intermediate Man5GlcNAc2 (&lt;2% complex type glycans).	Polysaccharides	262-269	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	33-38
20734133-3	2010	Scientists believe that a switch in the binding specificity of HA from Neu5Acalpha2-3Gal linked (alpha2-3) to Neu5Acalpha2-6Gal linked (alpha2-6) glycans is essential for the crossover of the viruses from avian to human hosts.	Polysaccharides	146-153	immunoglobulin binding protein 1	Homo sapiens	116-124
20734133-5	2010	A recent study reported extensive diversity in the structure and composition of alpha2-6 glycans (which goes beyond the sialic acid linkage) in human upper respiratory epithelia and identified different glycan structural topologies.	Polysaccharides	89-95	immunoglobulin binding protein 1	Homo sapiens	80-88
20734133-6	2010	Biochemical examination of the multivalent HA binding to these diverse sialylated glycan structures also demonstrated that high affinity binding of HA to alpha2-6 glycans with a characteristic umbrella-like structural topology is critical for efficient human adaptation and human-human transmission of influenza A viruses.	Polysaccharides	82-88	immunoglobulin binding protein 1	Homo sapiens	154-162
20820911-2	2010	A water-soluble polysaccharide (POP1) was isolated from Portulaca oleracea L. Four sulfated derivatives of POP1 (POP1-s1, POP1-s2, POP1-s3 and POP1-s4) were prepared by chlorosulfonic acid method with N,N-Dicyclohexylcarbodiimide (DCC) as a dehydration-condensation agent.	Polysaccharides	16-30	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	32-36
20820911-2	2010	A water-soluble polysaccharide (POP1) was isolated from Portulaca oleracea L. Four sulfated derivatives of POP1 (POP1-s1, POP1-s2, POP1-s3 and POP1-s4) were prepared by chlorosulfonic acid method with N,N-Dicyclohexylcarbodiimide (DCC) as a dehydration-condensation agent.	Polysaccharides	16-30	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	107-111
20820911-2	2010	A water-soluble polysaccharide (POP1) was isolated from Portulaca oleracea L. Four sulfated derivatives of POP1 (POP1-s1, POP1-s2, POP1-s3 and POP1-s4) were prepared by chlorosulfonic acid method with N,N-Dicyclohexylcarbodiimide (DCC) as a dehydration-condensation agent.	Polysaccharides	16-30	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	107-111
20820911-2	2010	A water-soluble polysaccharide (POP1) was isolated from Portulaca oleracea L. Four sulfated derivatives of POP1 (POP1-s1, POP1-s2, POP1-s3 and POP1-s4) were prepared by chlorosulfonic acid method with N,N-Dicyclohexylcarbodiimide (DCC) as a dehydration-condensation agent.	Polysaccharides	16-30	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	107-111
20820911-2	2010	A water-soluble polysaccharide (POP1) was isolated from Portulaca oleracea L. Four sulfated derivatives of POP1 (POP1-s1, POP1-s2, POP1-s3 and POP1-s4) were prepared by chlorosulfonic acid method with N,N-Dicyclohexylcarbodiimide (DCC) as a dehydration-condensation agent.	Polysaccharides	16-30	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	107-111
20820911-2	2010	A water-soluble polysaccharide (POP1) was isolated from Portulaca oleracea L. Four sulfated derivatives of POP1 (POP1-s1, POP1-s2, POP1-s3 and POP1-s4) were prepared by chlorosulfonic acid method with N,N-Dicyclohexylcarbodiimide (DCC) as a dehydration-condensation agent.	Polysaccharides	16-30	POP1 homolog, ribonuclease P/MRP subunit	Homo sapiens	107-111
20498265-2	2010	Here we reveal the role of LuxS in the regulation of capsular polysaccharide synthesis in S. aureus NCTC8325 and show that AI-2 can regulate gene expression and is involved in some physiological activities in S. aureus as a signaling molecule.	Polysaccharides	62-76	Lutheran suppressor, X-linked	Homo sapiens	27-31
20498265-3	2010	Inactivation of luxS in S. aureus NCTC8325 resulted in higher levels of transcription of capsular polysaccharide synthesis genes.	Polysaccharides	98-112	Lutheran suppressor, X-linked	Homo sapiens	16-20
20498265-6	2010	Furthermore, we demonstrated that the LuxS/AI-2 signaling system regulates capsular polysaccharide production via a two-component system, KdpDE, whose function has not yet been clarified in S. aureus.	Polysaccharides	84-98	Lutheran suppressor, X-linked	Homo sapiens	38-42
20483383-8	2010	In addition, the polysaccharide promoted in vivo Th1 immune response in mice which were immunized with sheep red blood cells (DTH and quantity of plaque-forming cells) and down regulated serum level of IgG1 and IgE during Th2-depend immune response induced by ovalbumin.	Polysaccharides	17-31	negative elongation factor complex member C/D, Th1l	Mus musculus	49-52
20483383-10	2010	Our results suggest that the pectic polysaccharide from A. calamus L. represents a promising immunomodulating agent that stimulates M1-polarized macrophages and promotes Th1-oriented adaptive immune response.	Polysaccharides	36-50	negative elongation factor complex member C/D, Th1l	Mus musculus	170-173
20144722-1	2010	Newly emerging genetic studies have revealed that a subset of the family of glycosyltransferases responsible for the formation of mucin-type O glycans is essential for normal development.	Polysaccharides	143-150	LOC100508689	Homo sapiens	130-135
20103567-8	2010	FcgammaRIIIa binding was strongly influenced by both the glycan structure/composition (namely galactose and fucose) and conformational changes that were induced by some of the modifications.	Polysaccharides	57-63	Fc gamma receptor IIIa	Homo sapiens	0-12
20726802-0	2010	Glycan characterization of PSA 2-DE subforms from serum and seminal plasma.	Polysaccharides	0-6	kallikrein related peptidase 3	Homo sapiens	27-30
20726802-6	2010	Furthermore, the analysis of F3, the more abundant PSA subform, showed a higher proportion of alpha 2-3 sialic acid and a decrease in core fucosylated glycans in the PCa sample.	Polysaccharides	151-158	kallikrein related peptidase 3	Homo sapiens	51-54
20466649-3	2010	Glycoproteomic analyses of purified recombinant human 190-HARE ecto-domain identified a diverse population of glycans at 10 of 17 consensus sites.	Polysaccharides	110-117	stabilin 2	Homo sapiens	58-62
20466838-7	2010	Exposure of the mucin to sodium metaperiodate recovered bacterial invasion levels, suggesting a glycan-mediated effect.	Polysaccharides	96-102	mucin 2, oligomeric mucus/gel-forming	Gallus gallus	16-21
20206280-1	2010	UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I (GnTI, encoded by Mgat1) first appeared in evolution at about the same time as metazoa suggesting that GnTI-dependent glycans are essential for the development of multicellular organisms.	Polysaccharides	190-197	mannoside acetylglucosaminyltransferase 1	Mus musculus	0-71
20206280-1	2010	UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I (GnTI, encoded by Mgat1) first appeared in evolution at about the same time as metazoa suggesting that GnTI-dependent glycans are essential for the development of multicellular organisms.	Polysaccharides	190-197	mannoside acetylglucosaminyltransferase 1	Mus musculus	73-77
20206280-1	2010	UDP-GlcNAc:alpha3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I (GnTI, encoded by Mgat1) first appeared in evolution at about the same time as metazoa suggesting that GnTI-dependent glycans are essential for the development of multicellular organisms.	Polysaccharides	190-197	mannoside acetylglucosaminyltransferase 1	Mus musculus	90-95
20501660-1	2010	Hyaluronan synthases (HAS1-3) are integral plasma membrane proteins that synthesize hyaluronan, a cell surface and extracellular matrix polysaccharide necessary for many biological processes.	Polysaccharides	136-150	hyaluronan synthase 1	Homo sapiens	22-28
20418283-2	2010	Blocking the addition of N-linked glycans (NLGs) or inhibiting initial glycan processing prevented secretion of VWF.	Polysaccharides	34-40	von Willebrand factor	Homo sapiens	112-115
20714287-2	2010	In this study, two polysaccharides (P31 and P32) were isolated from the aqueous extract of PV and purified through ethanol precipitation, followed by deproteination using DEAE-52 gel-filtration chromatography.	Polysaccharides	19-34	tubulin polyglutamylase complex subunit 1	Mus musculus	44-47
20657665-0	2010	Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation.	Polysaccharides	41-48	galectin 1	Homo sapiens	12-22
20661301-11	2010	Consisting predominantly of the sugars glucose and galactose, the capsular polysaccharide of A172, given in the dose of 25 microg/mouse, also protected the mice (20/20) from a lethal dose of A170.	Polysaccharides	75-89	sequestosome 1	Mus musculus	191-195
20561607-0	2010	Synthesis of an Fmoc-threonine bearing core-2 glycan: a building block for PSGL-1 via Fmoc-assisted solid-phase peptide synthesis.	Polysaccharides	46-52	selectin P ligand	Homo sapiens	75-81
20441997-4	2010	However, when treated with neuraminidase this HA was able to bind more glycans with similar specificity as HEK293S GnTI(-) cell-produced HA.	Polysaccharides	71-78	neuraminidase 1	Homo sapiens	27-40
20657665-5	2010	Characterization of the NiV-F N-glycome showed that the critical site for galectin-1 inhibition is rich in glycan structures known to bind galectin-1.	Polysaccharides	107-113	galectin 1	Homo sapiens	74-84
20507092-2	2010	IgA1 from IgAN patients is characterized by the presence of galactose (Gal)-deficient O-glycans in the hinge region that can act as epitopes for anti-glycan IgG or IgA1 antibodies.	Polysaccharides	88-94	immunoglobulin heavy constant alpha 1	Homo sapiens	0-4
20657665-5	2010	Characterization of the NiV-F N-glycome showed that the critical site for galectin-1 inhibition is rich in glycan structures known to bind galectin-1.	Polysaccharides	107-113	galectin 1	Homo sapiens	139-149
20507092-2	2010	IgA1 from IgAN patients is characterized by the presence of galactose (Gal)-deficient O-glycans in the hinge region that can act as epitopes for anti-glycan IgG or IgA1 antibodies.	Polysaccharides	88-94	IGAN1	Homo sapiens	10-14
20644724-5	2010	Thirty six exertional rhabdomyolysis-susceptible horses were subsequently genotyped for the skeletal muscle glycogen synthase (GYS1) mutation responsible for type 1 polysaccharide storage myopathy.	Polysaccharides	165-179	glycogen synthase 1	Equus caballus	127-131
20507092-2	2010	IgA1 from IgAN patients is characterized by the presence of galactose (Gal)-deficient O-glycans in the hinge region that can act as epitopes for anti-glycan IgG or IgA1 antibodies.	Polysaccharides	88-94	immunoglobulin heavy constant alpha 1	Homo sapiens	164-168
20515260-3	2010	Here the stimulation of esterification and inhibition of lipolysis by synthetic phosphoinositolglycans (PIGs), such as PIG37, which represents the glycan component of the GPI anchor, are shown to be correlated to translocation from DIGs to LD and release into adiposomes of Gce1 and CD73.	Polysaccharides	95-101	5'-nucleotidase ecto	Homo sapiens	283-287
20453127-0	2010	Disruption of the putative cell surface polysaccharide biosynthesis gene SO3177 in Shewanella oneidensis MR-1 enhances adhesion to electrodes and current generation in microbial fuel cells.	Polysaccharides	40-54	formyl transferase	Shewanella oneidensis MR-1	73-79
20453127-4	2010	Determination of the transposon insertion site in strain 4A followed by deletion and complementation experiments revealed that the SO3177 gene, encoding a putative formyltransferase and situated in a cell surface polysaccharide biosynthesis gene cluster, was responsible for the increased current.	Polysaccharides	213-227	formyl transferase	Shewanella oneidensis MR-1	131-137
20453127-5	2010	Transmission electron microscopy showed that a layered structure at the cell surface, stainable with ruthenium red, was impaired in the SO3177 mutant (DeltaSO3177), confirming that SO3177 is involved in the biosynthesis of cell surface polysaccharides.	Polysaccharides	236-251	formyl transferase	Shewanella oneidensis MR-1	136-142
20388707-8	2010	Although at least a portion of Muc21 was glycosylated with sialylated glycans, removal of sialic acid did not influence the prevention of adhesion.	Polysaccharides	70-77	mucin 21, cell surface associated	Homo sapiens	31-36
20445443-1	2010	Earlier studies of addition of naturally sulfated polysaccharides including unfractionated heparin showed a significant enhancement of the in-vitro activation of glutamic plasminogen (Glu-Plg) by tissue plasminogen activator (t-PA) or urokinase plasminogen activator (u-PA).	Polysaccharides	50-65	plasminogen	Homo sapiens	188-191
20445443-1	2010	Earlier studies of addition of naturally sulfated polysaccharides including unfractionated heparin showed a significant enhancement of the in-vitro activation of glutamic plasminogen (Glu-Plg) by tissue plasminogen activator (t-PA) or urokinase plasminogen activator (u-PA).	Polysaccharides	50-65	plasminogen activator, tissue type	Homo sapiens	226-230
20445443-1	2010	Earlier studies of addition of naturally sulfated polysaccharides including unfractionated heparin showed a significant enhancement of the in-vitro activation of glutamic plasminogen (Glu-Plg) by tissue plasminogen activator (t-PA) or urokinase plasminogen activator (u-PA).	Polysaccharides	50-65	plasminogen activator, urokinase	Homo sapiens	235-266
20445443-1	2010	Earlier studies of addition of naturally sulfated polysaccharides including unfractionated heparin showed a significant enhancement of the in-vitro activation of glutamic plasminogen (Glu-Plg) by tissue plasminogen activator (t-PA) or urokinase plasminogen activator (u-PA).	Polysaccharides	50-65	plasminogen activator, urokinase	Homo sapiens	268-272
20828009-6	2010	The main polysaccharide TPS2 and TPS1 were isolated and purified from pu-erh tea and its materials by DEAE-52 and Sephadex G-150 column chromatography.	Polysaccharides	9-23	trehalose-phosphatase TPS2	Saccharomyces cerevisiae S288C	24-28
20359956-0	2010	CD161 receptor participates in both impairing NK cell cytotoxicity and the response to glycans and vimentin in patients with rheumatoid arthritis.	Polysaccharides	87-94	killer cell lectin like receptor B1	Homo sapiens	0-5
20448018-9	2010	In conclusion, IgG glycan hydrolysis by EndoS attenuates ANCA-induced neutrophil activation in vitro and prevents induction of anti-MPO IgG/LPS-mediated NCGN in vivo.	Polysaccharides	19-25	myeloperoxidase	Mus musculus	132-135
20505146-0	2010	IL-7-dependent B lymphocytes are essential for the anti-polysaccharide response and protective immunity to Streptococcus pneumoniae.	Polysaccharides	56-70	interleukin 7	Mus musculus	0-4
20346410-7	2010	The enhanced sialylation of EPO produced by JW152 cells in the presence of GnT I over CHO-K1 cells is a result of increased sialylated glycan structures with higher antennary branching.	Polysaccharides	135-141	erythropoietin	Cricetulus griseus	28-31
20442276-4	2010	Glycan array screening showed that PP2-A1 also bound to high-mannose N-glycans and 9-acyl-N-acetylneuraminic sialic acid.	Polysaccharides	0-6	phloem protein 2-A1	Arabidopsis thaliana	35-41
20432412-0	2010	Synthesis of benzaldehyde-functionalized glycans: a novel approach towards glyco-SAMs as a tool for surface plasmon resonance studies.	Polysaccharides	41-48	methionine adenosyltransferase 1A	Homo sapiens	81-85
20188224-10	2010	The method developed was applied to progranulin (PGRN) to characterize the structures of the released glycans and to identify the sites of glycosylation.	Polysaccharides	102-109	granulin precursor	Homo sapiens	36-47
20188224-10	2010	The method developed was applied to progranulin (PGRN) to characterize the structures of the released glycans and to identify the sites of glycosylation.	Polysaccharides	102-109	granulin precursor	Homo sapiens	49-53
20369301-2	2010	Glycans participate substantially in Env folding and in the binding of virions to the host-cell surface and indirectly affect cellular uptake of HIV-1.	Polysaccharides	0-7	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	37-40
20434428-9	2010	The amount relative to other N-glycans was estimated to 2-6% of blood group H epitope-containing glycans released from GPA-O preparations and 1-2% of blood group A and B epitope-containing glycans, released from GPA-A and GPA-B, respectively.	Polysaccharides	97-104	glycophorin A (MNS blood group)	Homo sapiens	119-122
20455239-3	2010	Selective oxidation of the sialic acid residues on the glycan chains of transferrin was followed by introduction of a terminal alkyne functionality through an oxime linkage.	Polysaccharides	55-61	transferrin	Homo sapiens	72-83
20335177-4	2010	The present study attempted to elucidate how changes in VN glycans modulate the survival of HSCs, which play a critical role in liver regeneration.	Polysaccharides	59-66	vitronectin	Rattus norvegicus	56-58
20178128-7	2010	ACPA IgG1 glycan profiles were compared with glycan profiles of total serum IgG1 obtained from 85 well-characterized patients.	Polysaccharides	10-16	proteinase 3	Homo sapiens	0-4
20178128-11	2010	Moreover, differential ACPA glycan profiles were detected in rheumatoid factor (RF)-positive and RF-negative patients.	Polysaccharides	28-34	proteinase 3	Homo sapiens	23-27
20559567-2	2010	The actinomycete-derived lectin actinohivin (AH) is highly specific to a cluster of high-mannose-type glycans uniquely found on the viral envelope (Env).	Polysaccharides	102-109	endogenous retrovirus group K member 20	Homo sapiens	148-151
20181615-2	2010	A current clinical target for B-cell lymphoma is CD22, a B-cell-specific member of the sialic acid binding Ig-like lectin (siglec) family that recognizes alpha2-6-linked sialylated glycans as ligands.	Polysaccharides	181-188	CD22 molecule	Homo sapiens	49-53
20181615-3	2010	Here, we describe a novel approach for targeting B lymphoma cells with doxorubicin-loaded liposomal nanoparticles displaying high-affinity glycan ligands of CD22.	Polysaccharides	139-145	CD22 molecule	Homo sapiens	157-161
20385555-8	2010	In worms having the bus-2 genetic background, core-1 glycans are decreased, whereas the novel fucosyl O-glycans are increased in abundance in this region.	Polysaccharides	53-60	Hexosyltransferase	Caenorhabditis elegans	20-25
20178128-12	2010	CONCLUSION: ACPA IgG1 exhibit a specific Fc-linked glycan profile that is distinct from that of total serum IgG1.	Polysaccharides	51-57	proteinase 3	Homo sapiens	12-16
20369301-3	2010	Moreover, Env glycans could protect HIV-1 from host"s neutralizing antibodies, but some glycans, on the other hand, represent targets for neutralizing antibodies.	Polysaccharides	14-21	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	10-13
20369301-4	2010	Variability of Env and its glycans in the HIV-1 strains from around the world as well as in patients during disease progression contributes substantially to further HIV-1 spreading in spite of the progress in basic HIV-1 research, vaccine development, and highly active antiretroviral therapy of HIV-1 infections.	Polysaccharides	27-34	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	15-18
20726346-0	2010	[Effect of plant polysaccharides on TH1-dependent immune response: screening investigation].	Polysaccharides	17-32	negative elongation factor complex member C/D, Th1l	Mus musculus	36-39
20726346-3	2010	All the investigated polysaccharides have stimulated a Th1 response.	Polysaccharides	21-36	negative elongation factor complex member C/D, Th1l	Mus musculus	55-58
20347925-5	2010	RESULTS: We found that polysaccharide (ASPS) was the major component responsible for the hematopoietic effect of Angelica sinensis.	Polysaccharides	23-37	alveolar soft part sarcoma chromosome region, candidate 1 (human)	Mus musculus	39-43
20382770-0	2010	RmpA regulation of capsular polysaccharide biosynthesis in Klebsiella pneumoniae CG43.	Polysaccharides	28-42	regulator of mucoid phenotype	Klebsiella pneumoniae CG43	0-4
20382770-2	2010	Promoter activity measurement indicated that the deletion of rmpA reduced K2 capsular polysaccharide (CPS) biosynthesis, resulting in decreased colony mucoidy and virulence in mice.	Polysaccharides	86-100	regulator of mucoid phenotype	Klebsiella pneumoniae CG43	61-65
20512925-3	2010	We earlier showed that carboxylated glycans on the V-domain of RAGE promote the binding of HMGB1 and S100A8/A9.	Polysaccharides	36-43	advanced glycosylation end-product specific receptor	Homo sapiens	63-67
20512925-3	2010	We earlier showed that carboxylated glycans on the V-domain of RAGE promote the binding of HMGB1 and S100A8/A9.	Polysaccharides	36-43	high mobility group box 1	Homo sapiens	91-96
20512925-3	2010	We earlier showed that carboxylated glycans on the V-domain of RAGE promote the binding of HMGB1 and S100A8/A9.	Polysaccharides	36-43	S100 calcium binding protein A8	Homo sapiens	101-110
20512925-4	2010	Here we study the role of these glycans on the binding and intracellular signaling mediated by another RAGE ligand, S100A12.	Polysaccharides	32-39	advanced glycosylation end-product specific receptor	Homo sapiens	103-107
20512925-4	2010	Here we study the role of these glycans on the binding and intracellular signaling mediated by another RAGE ligand, S100A12.	Polysaccharides	32-39	S100 calcium binding protein A12	Homo sapiens	116-123
20512925-5	2010	S100A12 binds carboxylated glycans, and a subpopulation of RAGE enriched for carboxylated glycans shows more than 10-fold higher binding potential for S100A12 than total RAGE.	Polysaccharides	27-34	S100 calcium binding protein A12	Homo sapiens	0-7
20512925-5	2010	S100A12 binds carboxylated glycans, and a subpopulation of RAGE enriched for carboxylated glycans shows more than 10-fold higher binding potential for S100A12 than total RAGE.	Polysaccharides	27-34	advanced glycosylation end-product specific receptor	Homo sapiens	59-63
20512925-5	2010	S100A12 binds carboxylated glycans, and a subpopulation of RAGE enriched for carboxylated glycans shows more than 10-fold higher binding potential for S100A12 than total RAGE.	Polysaccharides	27-34	S100 calcium binding protein A12	Homo sapiens	151-158
20512925-5	2010	S100A12 binds carboxylated glycans, and a subpopulation of RAGE enriched for carboxylated glycans shows more than 10-fold higher binding potential for S100A12 than total RAGE.	Polysaccharides	27-34	advanced glycosylation end-product specific receptor	Homo sapiens	170-174
20512925-5	2010	S100A12 binds carboxylated glycans, and a subpopulation of RAGE enriched for carboxylated glycans shows more than 10-fold higher binding potential for S100A12 than total RAGE.	Polysaccharides	90-97	advanced glycosylation end-product specific receptor	Homo sapiens	59-63
20512925-5	2010	S100A12 binds carboxylated glycans, and a subpopulation of RAGE enriched for carboxylated glycans shows more than 10-fold higher binding potential for S100A12 than total RAGE.	Polysaccharides	90-97	S100 calcium binding protein A12	Homo sapiens	151-158
20512925-5	2010	S100A12 binds carboxylated glycans, and a subpopulation of RAGE enriched for carboxylated glycans shows more than 10-fold higher binding potential for S100A12 than total RAGE.	Polysaccharides	90-97	advanced glycosylation end-product specific receptor	Homo sapiens	170-174
20512925-6	2010	When expressed in mammalian cells, RAGE is modified by complex glycans predominantly at the first glycosylation site (N25IT) that retains S100A12 binding.	Polysaccharides	63-70	advanced glycosylation end-product specific receptor	Homo sapiens	35-39
20512925-6	2010	When expressed in mammalian cells, RAGE is modified by complex glycans predominantly at the first glycosylation site (N25IT) that retains S100A12 binding.	Polysaccharides	63-70	S100 calcium binding protein A12	Homo sapiens	138-145
20512925-8	2010	Carboxylated glycan-enriched population of RAGE forms higher order multimeric complexes with S100A12, and this ability to multimerize is reduced upon deglycosylation or by using non-glycosylated sRAGE expressed in E. coli.	Polysaccharides	13-19	advanced glycosylation end-product specific receptor	Homo sapiens	43-47
20512925-8	2010	Carboxylated glycan-enriched population of RAGE forms higher order multimeric complexes with S100A12, and this ability to multimerize is reduced upon deglycosylation or by using non-glycosylated sRAGE expressed in E. coli.	Polysaccharides	13-19	S100 calcium binding protein A12	Homo sapiens	93-100
20512925-9	2010	mAbGB3.1, an antibody against carboxylated glycans, blocks S100A12-mediated NF-kappaB signaling in HeLa cells expressing full-length RAGE.	Polysaccharides	43-50	S100 calcium binding protein A12	Homo sapiens	59-66
20363856-6	2010	In most cases, multiple subclades of antibodies were observed to bind to each glycan class, suggesting that the mAbs in these subgroups recognize distinct epitopes present on the cell wall glycans.	Polysaccharides	78-84	DEAD box helicase 41	Mus musculus	112-116
20172905-1	2010	CD22, a regulator of B-cell signaling, is a siglec that recognizes the sequence NeuAcalpha2-6Gal on glycoprotein glycans as ligands.	Polysaccharides	113-120	CD22 molecule	Homo sapiens	0-4
20363856-1	2010	A collection of 130 new plant cell wall glycan-directed monoclonal antibodies (mAbs) was generated with the aim of facilitating in-depth analysis of cell wall glycans.	Polysaccharides	40-46	DEAD box helicase 41	Mus musculus	79-83
20363856-1	2010	A collection of 130 new plant cell wall glycan-directed monoclonal antibodies (mAbs) was generated with the aim of facilitating in-depth analysis of cell wall glycans.	Polysaccharides	159-166	DEAD box helicase 41	Mus musculus	79-83
20521989-6	2010	The polysaccharide isolated by hot alkaline extraction and chromatography was designated as AE2 and studied for its immunostimulatory potential in vivo in a murine model.	Polysaccharides	4-18	solute carrier family 4 (anion exchanger), member 2	Mus musculus	92-95
20363856-2	2010	An enzyme-linked immunosorbent assay-based screen against a diverse panel of 54 plant polysaccharides was used to characterize the binding patterns of these new mAbs, together with 50 other previously generated mAbs, against plant cell wall glycans.	Polysaccharides	86-101	DEAD box helicase 41	Mus musculus	161-165
20363856-6	2010	In most cases, multiple subclades of antibodies were observed to bind to each glycan class, suggesting that the mAbs in these subgroups recognize distinct epitopes present on the cell wall glycans.	Polysaccharides	189-196	DEAD box helicase 41	Mus musculus	112-116
20363856-2	2010	An enzyme-linked immunosorbent assay-based screen against a diverse panel of 54 plant polysaccharides was used to characterize the binding patterns of these new mAbs, together with 50 other previously generated mAbs, against plant cell wall glycans.	Polysaccharides	241-248	DEAD box helicase 41	Mus musculus	161-165
20363856-3	2010	Hierarchical clustering analysis was used to group these mAbs based on the polysaccharide recognition patterns observed.	Polysaccharides	75-89	DEAD box helicase 41	Mus musculus	57-61
20363856-7	2010	The epitopes recognized by many of the mAbs in the toolkit, particularly those recognizing arabinose- and/or galactose-containing structures, are present on more than one glycan class, consistent with the known structural diversity and complexity of plant cell wall glycans.	Polysaccharides	171-177	DEAD box helicase 41	Mus musculus	39-43
20363856-5	2010	The mAbs could be resolved into 19 clades of antibodies that recognize distinct epitopes present on all major classes of plant cell wall glycans, including arabinogalactans (both protein- and polysaccharide-linked), pectins (homogalacturonan, rhamnogalacturonan I), xyloglucans, xylans, mannans, and glucans.	Polysaccharides	137-144	DEAD box helicase 41	Mus musculus	4-8
20363856-5	2010	The mAbs could be resolved into 19 clades of antibodies that recognize distinct epitopes present on all major classes of plant cell wall glycans, including arabinogalactans (both protein- and polysaccharide-linked), pectins (homogalacturonan, rhamnogalacturonan I), xyloglucans, xylans, mannans, and glucans.	Polysaccharides	192-206	DEAD box helicase 41	Mus musculus	4-8
20363856-7	2010	The epitopes recognized by many of the mAbs in the toolkit, particularly those recognizing arabinose- and/or galactose-containing structures, are present on more than one glycan class, consistent with the known structural diversity and complexity of plant cell wall glycans.	Polysaccharides	266-273	DEAD box helicase 41	Mus musculus	39-43
20363856-8	2010	Thus, these cell wall glycan-directed mAbs should be viewed and utilized as epitope-specific, rather than polymer-specific, probes.	Polysaccharides	22-28	DEAD box helicase 41	Mus musculus	38-42
20594465-11	2010	CONCLUSION: The study provides the evidence that TREM-1 natural ligand(s) is present on cell wall of bacteria including Staphylococcus aureus and Pseudomonas aeruginosa, and it might be polysaccharides.	Polysaccharides	186-201	triggering receptor expressed on myeloid cells 1	Homo sapiens	49-55
20369886-3	2010	The N295 and N332 glycans at the base of V3 are usually characterized as high-mannose type in gp120, and the N301 glycan is a complex type.	Polysaccharides	18-25	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	94-99
20369886-3	2010	The N295 and N332 glycans at the base of V3 are usually characterized as high-mannose type in gp120, and the N301 glycan is a complex type.	Polysaccharides	18-24	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	94-99
20439727-4	2010	These data imply that N-glycans on ESL-1 and CD44 and O-glycans on PSGL-1 constitute all E-selectin ligands, with neither glycan subset having a dominant role.	Polysaccharides	24-30	golgi apparatus protein 1	Mus musculus	35-40
20439727-4	2010	These data imply that N-glycans on ESL-1 and CD44 and O-glycans on PSGL-1 constitute all E-selectin ligands, with neither glycan subset having a dominant role.	Polysaccharides	24-30	selectin, endothelial cell	Mus musculus	89-99
20056895-6	2010	Importantly, patients with an elevation of total bilirubin level (&gt;2 mg/dl) had a strong increase of glycans modified with alpha1-6 fucose.	Polysaccharides	104-111	adrenoceptor alpha 1D	Homo sapiens	126-134
20439703-1	2010	Cosmc is a molecular chaperone thought to be required for expression of active T-synthase, the only enzyme that galactosylates the Tn antigen (GalNAcalpha1-Ser/Thr-R) to form core 1 Galbeta1-3GalNAcalpha1-Ser/Thr (T antigen) during mucin type O-glycan biosynthesis.	Polysaccharides	245-251	C1GALT1-specific chaperone 1	Mus musculus	0-5
20439703-1	2010	Cosmc is a molecular chaperone thought to be required for expression of active T-synthase, the only enzyme that galactosylates the Tn antigen (GalNAcalpha1-Ser/Thr-R) to form core 1 Galbeta1-3GalNAcalpha1-Ser/Thr (T antigen) during mucin type O-glycan biosynthesis.	Polysaccharides	245-251	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1	Mus musculus	79-89
20226439-2	2010	As a result, the polymeric cell-wall material (CWM) initially associated with these polysaccharides was released into solution (AXL and AXC for lichenase- and cellulase-extractable fractions, respectively).	Polysaccharides	84-99	AXL receptor tyrosine kinase	Homo sapiens	128-131
20348404-8	2010	RESULTS: We found that branching alpha-1,3-fucosylated multiantennary glycans on hemopexin were increased in the HCC group compared with the cirrhosis without HCC, fibrosis, and healthy volunteer groups, whereas nonmodified biantennary glycans decreased progressively across groups from fibrosis to the cirrhosis and HCC groups.	Polysaccharides	70-77	hemopexin	Homo sapiens	81-90
20395854-7	2010	RESULTS: The detection of a glycan variant on MUC5AC using the lectin wheat-germ agglutinin discriminated mucin-producing cystic tumors (mucinous cystic neoplasms+intraductal papillary mucinous neoplasms) from benign cystic lesions (serous cystadenomas+pseudocysts) with a 78% sensitivity at 80% specificity, and when used in combination with cyst fluid CA 19-9 gave a sensitivity of 87% at 86% specificity.	Polysaccharides	28-34	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	46-52
20395854-7	2010	RESULTS: The detection of a glycan variant on MUC5AC using the lectin wheat-germ agglutinin discriminated mucin-producing cystic tumors (mucinous cystic neoplasms+intraductal papillary mucinous neoplasms) from benign cystic lesions (serous cystadenomas+pseudocysts) with a 78% sensitivity at 80% specificity, and when used in combination with cyst fluid CA 19-9 gave a sensitivity of 87% at 86% specificity.	Polysaccharides	28-34	LOC100508689	Homo sapiens	106-111
20348404-8	2010	RESULTS: We found that branching alpha-1,3-fucosylated multiantennary glycans on hemopexin were increased in the HCC group compared with the cirrhosis without HCC, fibrosis, and healthy volunteer groups, whereas nonmodified biantennary glycans decreased progressively across groups from fibrosis to the cirrhosis and HCC groups.	Polysaccharides	236-243	hemopexin	Homo sapiens	81-90
20348404-11	2010	The hemopexin glycan marker could be a valuable complementary test to alpha-fetoprotein measurements for detection of HCC in patients with cirrhosis.	Polysaccharides	14-20	hemopexin	Homo sapiens	4-13
20102547-4	2010	Here,we show that ERGIC-53 binds to the conserved Asn563 glycan in the C-terminal micro(s) tailpiece (micro(s)tp).	Polysaccharides	57-63	lectin, mannose binding 1	Homo sapiens	18-26
20145095-4	2010	In addition, purified K5 polysaccharide was capable of inducing expression of TLR5 and mCD14 and potentiated the activity of both TLR4 and TLR5 agonists to increase the proinflammatory response.	Polysaccharides	25-39	toll like receptor 5	Homo sapiens	78-82
20145095-4	2010	In addition, purified K5 polysaccharide was capable of inducing expression of TLR5 and mCD14 and potentiated the activity of both TLR4 and TLR5 agonists to increase the proinflammatory response.	Polysaccharides	25-39	CD14 antigen	Mus musculus	87-92
20145095-4	2010	In addition, purified K5 polysaccharide was capable of inducing expression of TLR5 and mCD14 and potentiated the activity of both TLR4 and TLR5 agonists to increase the proinflammatory response.	Polysaccharides	25-39	toll like receptor 4	Homo sapiens	130-134
20145095-4	2010	In addition, purified K5 polysaccharide was capable of inducing expression of TLR5 and mCD14 and potentiated the activity of both TLR4 and TLR5 agonists to increase the proinflammatory response.	Polysaccharides	25-39	toll like receptor 5	Homo sapiens	139-143
19230716-0	2010	Astragalus polysaccharides inhibited diabetic cardiomyopathy in hamsters depending on suppression of heart chymase activation.	Polysaccharides	11-26	chymase 1	Homo sapiens	107-114
20102547-5	2010	Removal of this glycan inhibits ERGIC-53 binding and results in the rapid formation of larger polymeric assemblies.	Polysaccharides	16-22	lectin, mannose binding 1	Homo sapiens	32-40
20118238-9	2010	Thus, 2OST Y94I cannot sulfate N-sulfated heparosan, a polysaccharide containing glucuronic acid.	Polysaccharides	55-69	heparan sulfate 2-O-sulfotransferase 1	Homo sapiens	6-10
20382864-6	2010	Further, we show HIP/PAP binding affinity for carbohydrate ligands depends on carbohydrate chain length, supporting a binding model in which HIP/PAP molecules "bind and jump" along the extended polysaccharide chains of peptidoglycan, reducing dissociation rates and increasing binding affinity.	Polysaccharides	194-208	regenerating family member 3 alpha	Homo sapiens	17-24
20382864-6	2010	Further, we show HIP/PAP binding affinity for carbohydrate ligands depends on carbohydrate chain length, supporting a binding model in which HIP/PAP molecules "bind and jump" along the extended polysaccharide chains of peptidoglycan, reducing dissociation rates and increasing binding affinity.	Polysaccharides	194-208	regenerating family member 3 alpha	Homo sapiens	141-148
20181944-6	2010	Glycan array screening with the trimeric fragment shows that high mannose oligosaccharides are the best ligands for langerin.	Polysaccharides	0-6	CD207 molecule	Homo sapiens	116-124
20060827-1	2010	Extracellular translocation of the polysaccharide, hyaluronan (HA) has been thought to be mediated via its transmembrane synthetic enzyme, hyaluronan synthase (HAS) but recent studies have indicated that the ATP-Binding-Cassette (ABC) transporter, MRP5 contributes to this process.	Polysaccharides	35-49	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	230-233
20060827-1	2010	Extracellular translocation of the polysaccharide, hyaluronan (HA) has been thought to be mediated via its transmembrane synthetic enzyme, hyaluronan synthase (HAS) but recent studies have indicated that the ATP-Binding-Cassette (ABC) transporter, MRP5 contributes to this process.	Polysaccharides	35-49	ATP binding cassette subfamily C member 5	Homo sapiens	248-252
20199105-5	2010	Furthermore, the fully N-glycosylated beta(2) subunit is retained in the ER when glycan-calnexin interactions are prevented by castanospermine, showing that N-glycan-mediated calnexin binding is required for correct subunit folding.	Polysaccharides	81-87	calnexin	Canis lupus familiaris	88-96
20213680-4	2010	The GSL structure is characterized by two entities: a hydrophilic glycan and a hydrophobic ceramide moiety.	Polysaccharides	66-72	cathepsin A	Homo sapiens	4-7
20306342-5	2010	Interestingly, the lectin showed high affinity for glycans which are part of ovarian cancer marker CA125, a high molecular weight mucin containing high mannose and complex bisecting type N-linked glycans as well core 1 and 2 type O-glycans.	Polysaccharides	51-58	LOC100508689	Homo sapiens	130-135
19965639-3	2010	In this study, the role of terminal sialic acid residues on VWF glycans in mediating proteolysis by ADAMTS13 was investigated.	Polysaccharides	64-71	von Willebrand factor	Homo sapiens	60-63
19965639-3	2010	In this study, the role of terminal sialic acid residues on VWF glycans in mediating proteolysis by ADAMTS13 was investigated.	Polysaccharides	64-71	ADAM metallopeptidase with thrombospondin type 1 motif 13	Homo sapiens	100-108
19951367-7	2010	We also demonstrated that the binding of galectin-3 to host N-acetyllactosamine-containing glycans, was required for forming the structures.	Polysaccharides	91-98	galectin 3	Homo sapiens	41-51
20127679-5	2010	By deletion of the carbohydrate-recognition domain region and mutation of crucial amino acids involved in carbohydrate-recognition of LSECtin and by inhibition of the N-linked glycosylation of CD44, we further demonstrated that the interaction between CD44 and LSECtin is dependent on protein-glycan recognition.	Polysaccharides	293-299	C-type lectin domain family 4 member G	Homo sapiens	134-141
20127679-5	2010	By deletion of the carbohydrate-recognition domain region and mutation of crucial amino acids involved in carbohydrate-recognition of LSECtin and by inhibition of the N-linked glycosylation of CD44, we further demonstrated that the interaction between CD44 and LSECtin is dependent on protein-glycan recognition.	Polysaccharides	293-299	CD44 molecule (Indian blood group)	Homo sapiens	193-197
20127679-5	2010	By deletion of the carbohydrate-recognition domain region and mutation of crucial amino acids involved in carbohydrate-recognition of LSECtin and by inhibition of the N-linked glycosylation of CD44, we further demonstrated that the interaction between CD44 and LSECtin is dependent on protein-glycan recognition.	Polysaccharides	293-299	CD44 molecule (Indian blood group)	Homo sapiens	252-256
20093201-6	2010	These results demonstrated that oligosaccharide and amino acid fractions, as well as polysaccharide fraction of Radix A. sinensis, could serve as immunomodulator and TLR4 as one of the immune receptors may play important role for this action.	Polysaccharides	85-99	toll-like receptor 4	Mus musculus	166-170
20018245-3	2010	Although this system yields high amounts of recombinant protein, the BLG produced is usually associated with extracellular polysaccharides, which is problematic for NMR analysis.	Polysaccharides	123-138	beta-lactoglobulin	Bos taurus	69-72
20101628-6	2010	Increasing evidence suggests that carbohydrate structures (glycans), for example, phosphorylcholine-modified glycans or Galbeta1-4(Fucalpha1-3)GlcNAc- (Lewis X, Le(X)) containing glycans, expressed by the worms contribute to these modulating properties by their interaction with antigen presenting cells.	Polysaccharides	59-66	fucosyltransferase 4	Homo sapiens	161-166
20101628-6	2010	Increasing evidence suggests that carbohydrate structures (glycans), for example, phosphorylcholine-modified glycans or Galbeta1-4(Fucalpha1-3)GlcNAc- (Lewis X, Le(X)) containing glycans, expressed by the worms contribute to these modulating properties by their interaction with antigen presenting cells.	Polysaccharides	109-116	fucosyltransferase 4	Homo sapiens	161-166
20101628-6	2010	Increasing evidence suggests that carbohydrate structures (glycans), for example, phosphorylcholine-modified glycans or Galbeta1-4(Fucalpha1-3)GlcNAc- (Lewis X, Le(X)) containing glycans, expressed by the worms contribute to these modulating properties by their interaction with antigen presenting cells.	Polysaccharides	109-116	fucosyltransferase 4	Homo sapiens	161-166
20200279-2	2010	The glycan fragments serve as MHC class II (MHC II) ligands and innate receptor agonists, whereas microbial proteins serve as substrates for proteolytic cleavage and MHC II presentation, and released nucleic acids activate innate pattern-recognition receptors (e.g., TLR9).	Polysaccharides	4-10	toll like receptor 9	Homo sapiens	267-271
20147410-0	2010	NKp46 O-glycan sequences that are involved in the interaction with hemagglutinin type 1 of influenza virus.	Polysaccharides	8-14	natural cytotoxicity triggering receptor 1	Rattus norvegicus	0-5
19911254-0	2010	MS80, a novel sulfated polysaccharide, inhibits CD40-NF-kappaB pathway via targeting RIP2.	Polysaccharides	23-37	CD40 molecule	Homo sapiens	48-52
19911254-0	2010	MS80, a novel sulfated polysaccharide, inhibits CD40-NF-kappaB pathway via targeting RIP2.	Polysaccharides	23-37	nuclear factor kappa B subunit 1	Homo sapiens	53-62
19911254-0	2010	MS80, a novel sulfated polysaccharide, inhibits CD40-NF-kappaB pathway via targeting RIP2.	Polysaccharides	23-37	receptor interacting serine/threonine kinase 2	Homo sapiens	85-89
20092352-10	2010	Glycan preference was mapped to binding site 2, since reciprocal mutation of a single amino acid (asparagine 32 of Stx1 B-subunit/serine 31 of Stx2 B-subunit) reversed binding preference.	Polysaccharides	0-6	syntaxin 1A	Homo sapiens	115-119
20171319-7	2010	The proposed approach was applied to the analysis of hydrolyzed colloidal polysaccharides in seawater collected from the Baltic Sea.	Polysaccharides	74-89	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	128-131
20092352-10	2010	Glycan preference was mapped to binding site 2, since reciprocal mutation of a single amino acid (asparagine 32 of Stx1 B-subunit/serine 31 of Stx2 B-subunit) reversed binding preference.	Polysaccharides	0-6	syntaxin 2	Homo sapiens	143-147
20092352-12	2010	Varying glycan structure and density across different in vitro binding platforms revealed important differences in receptor binding properties between Stx1 and Stx2.	Polysaccharides	8-14	syntaxin 1A	Homo sapiens	151-155
20092352-12	2010	Varying glycan structure and density across different in vitro binding platforms revealed important differences in receptor binding properties between Stx1 and Stx2.	Polysaccharides	8-14	syntaxin 2	Homo sapiens	160-164
20162350-9	2010	For instance, an enhanced alpha2,6 sialylation was observed after TNF stimulation at the transcriptional and glycan expression level whereas transcription of ST3Gal1 sialylating in alpha2,3 position was enhanced after VEGF stimulation.	Polysaccharides	109-115	tumor necrosis factor	Homo sapiens	66-69
19917667-0	2010	Human XTP3-B binds to alpha1-antitrypsin variant null(Hong Kong) via the C-terminal MRH domain in a glycan-dependent manner.	Polysaccharides	100-106	endoplasmic reticulum lectin 1	Homo sapiens	6-12
19733354-8	2010	On the other hand, experimental huCETP expression protects mice from the harmful effects of a bacterial polysaccharide infusion and the mortality rate of severely ill patients correlates with reduction of the plasma CETP concentration.	Polysaccharides	104-118	cholesteryl ester transfer protein	Homo sapiens	34-38
19907056-3	2010	Previous efforts to identify the fine structure of the O-glucose-containing glycan of mammalian Notch have been hindered by limitations associated with approaches used to date.	Polysaccharides	76-82	Notch	Drosophila melanogaster	96-101
19907056-7	2010	These studies collectively reveal that the O-glucose-containing glycan decorating mammalian Notch is the D-Xyl-alpha1-3-D-Xyl-alpha1-3-D-Glc trisaccharide; an assignment in accord with previous predictions.	Polysaccharides	64-70	Notch	Drosophila melanogaster	92-97
19920089-6	2010	The gp120 binding activity of these immune sera was due to mannose-specific immunoglobulin, as removal of high-mannose glycans and alpha1,2-linked mannoses from gp120 abrogated serum binding.	Polysaccharides	119-126	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	4-9
19917667-0	2010	Human XTP3-B binds to alpha1-antitrypsin variant null(Hong Kong) via the C-terminal MRH domain in a glycan-dependent manner.	Polysaccharides	100-106	serpin family A member 1	Homo sapiens	22-40
19917667-6	2010	Arg428 and Tyr457 are homologous to amino acids that mediate glycan binding by the cation-dependent mannose-6-phosphate receptor.	Polysaccharides	61-67	mannose-6-phosphate receptor, cation dependent	Homo sapiens	83-128
19917667-8	2010	The glycan-binding-deficient XTP3-BDelta2 did not bind either AT or AT(NHK).	Polysaccharides	4-10	store-operated calcium entry associated regulatory factor	Homo sapiens	29-33
19917667-9	2010	These results suggest that XTP3-B specifically binds to AT(NHK), which is a well-known substrate of ERAD, via a C-terminal MRH domain in a glycan-dependent manner.	Polysaccharides	139-145	endoplasmic reticulum lectin 1	Homo sapiens	27-33
19920089-2	2010	Compared to normal mammalian glycoproteins, high-mannose-type glycans are disproportionately represented on the gp120 subunit of Env.	Polysaccharides	62-69	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	112-117
19920089-2	2010	Compared to normal mammalian glycoproteins, high-mannose-type glycans are disproportionately represented on the gp120 subunit of Env.	Polysaccharides	62-69	endogenous retrovirus group K member 20	Homo sapiens	129-132
20126979-4	2010	PSK, a protein-bound polysaccharide, has been used as a chemoimmunotherapy agent in the treatment of cancer in Asia for over 30 years.	Polysaccharides	21-35	TAO kinase 2	Homo sapiens	0-3
19909376-4	2010	In this study, the immunomodulatory effects of purified fractionated polysaccharides (GF2) from A. camphorata on dendritic cells (DCs) and their potential preventive effects against ovalbumin (OVA) -induced asthma were investigated.	Polysaccharides	69-84	gonadal fat pad weight 2	Mus musculus	86-89
19686089-1	2010	Galectin-3 is an endogenous lectin that binds glycan epitopes of cell membrane and some extracellular glycoproteins such as integrins and laminin.	Polysaccharides	46-52	galectin 3	Homo sapiens	0-10
20209506-6	2010	A total of 23 glycan structures, including sialylated bi- and tri-antennary complex type glycans, were characterized at three N-glycosylation sites, namely Asn-143, Asn-174 and Asn-234, of beta2-GPI.	Polysaccharides	14-20	apolipoprotein H	Homo sapiens	189-198
20209506-6	2010	A total of 23 glycan structures, including sialylated bi- and tri-antennary complex type glycans, were characterized at three N-glycosylation sites, namely Asn-143, Asn-174 and Asn-234, of beta2-GPI.	Polysaccharides	89-96	apolipoprotein H	Homo sapiens	189-198
20560256-1	2010	Hereditary deficiency of complement component C1q is a rare genetic disorder with susceptibility to recurrent infections with polysaccharide-containing encapsulated microorganisms and a high prevalence of autoimmune diseases, most often systemic lupus erythematosus (SLE).	Polysaccharides	126-140	complement C1q A chain	Homo sapiens	46-49
19653192-0	2010	Protective effect of Astragalus polysaccharides on ATP binding cassette transporter A1 in THP-1 derived foam cells exposed to tumor necrosis factor-alpha.	Polysaccharides	32-47	GLI family zinc finger 2	Homo sapiens	90-95
19653192-0	2010	Protective effect of Astragalus polysaccharides on ATP binding cassette transporter A1 in THP-1 derived foam cells exposed to tumor necrosis factor-alpha.	Polysaccharides	32-47	tumor necrosis factor	Homo sapiens	126-153
20026605-8	2010	Langerin also recognized pathogenic fungi, such as Candida and Malassezia, expressing heavily mannosylated glycans.	Polysaccharides	107-114	CD207 molecule	Homo sapiens	0-8
20545201-8	2010	The levels of TNF-alpha and IL-6 were significantly higher than those of the control group after 1.0, 5.0, 10.0 mmol x L(-1) of polysaccharides of snakegourd root stimulation on the human PBMC at 8 hours (P &lt; 0.05).	Polysaccharides	128-143	tumor necrosis factor	Homo sapiens	14-23
20545201-8	2010	The levels of TNF-alpha and IL-6 were significantly higher than those of the control group after 1.0, 5.0, 10.0 mmol x L(-1) of polysaccharides of snakegourd root stimulation on the human PBMC at 8 hours (P &lt; 0.05).	Polysaccharides	128-143	interleukin 6	Homo sapiens	28-32
20545201-11	2010	The high levels of TNF-alpha and IL-6 are secreted after the polysaccharides of snakegourd root stimulation on the human PBMC, which lays a foundation for further elucidating the immunocompetence effects and mechanism of the polysaccharide of snakegourd root.	Polysaccharides	61-76	tumor necrosis factor	Homo sapiens	19-28
20545201-11	2010	The high levels of TNF-alpha and IL-6 are secreted after the polysaccharides of snakegourd root stimulation on the human PBMC, which lays a foundation for further elucidating the immunocompetence effects and mechanism of the polysaccharide of snakegourd root.	Polysaccharides	61-76	interleukin 6	Homo sapiens	33-37
20545201-11	2010	The high levels of TNF-alpha and IL-6 are secreted after the polysaccharides of snakegourd root stimulation on the human PBMC, which lays a foundation for further elucidating the immunocompetence effects and mechanism of the polysaccharide of snakegourd root.	Polysaccharides	61-75	tumor necrosis factor	Homo sapiens	19-28
20545201-11	2010	The high levels of TNF-alpha and IL-6 are secreted after the polysaccharides of snakegourd root stimulation on the human PBMC, which lays a foundation for further elucidating the immunocompetence effects and mechanism of the polysaccharide of snakegourd root.	Polysaccharides	61-75	interleukin 6	Homo sapiens	33-37
20026605-0	2010	Dual specificity of Langerin to sulfated and mannosylated glycans via a single C-type carbohydrate recognition domain.	Polysaccharides	58-65	CD207 molecule	Homo sapiens	20-28
20026605-3	2010	Here, we investigated the glycan-binding specificity of Langerin using comprehensive glycoconjugate microarray, quantitative frontal affinity chromatography, and conventional cell biological analyses.	Polysaccharides	26-32	CD207 molecule	Homo sapiens	56-64
20026605-9	2010	These observations provide strong evidence that Langerin mediates diverse functions on Langerhans cells through dual recognition of sulfated as well as mannosylated glycans by its uniquely evolved C-type carbohydrate-recognition domain.	Polysaccharides	165-172	CD207 molecule	Homo sapiens	48-56
20067767-2	2010	Here we use a dendritic cell-mediated model to verify that a sulphated polysaccharide, fucoidin, can regulate the adverse regulatory function of SR-A, and lead to the up-regulation of the anti-tumor immunological response.	Polysaccharides	71-85	macrophage scavenger receptor 1	Homo sapiens	145-149
19959473-5	2010	We show that interactions with the thiol oxidoreductase ERp57 and substrate glycans are important for the recruitment of calreticulin into the PLC and for its functional activities in MHC class I assembly.	Polysaccharides	76-83	calreticulin	Homo sapiens	121-133
19959473-9	2010	However, such binding sites could contribute to substrate stabilization in a step that follows the glycan and ERp57-dependent recruitment of calreticulin to the PLC.	Polysaccharides	99-105	calreticulin	Homo sapiens	141-153
20032467-0	2010	Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin.	Polysaccharides	55-61	ficolin 1	Homo sapiens	125-134
20032467-6	2010	M-ficolin bound preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage.	Polysaccharides	99-106	ficolin 1	Homo sapiens	0-9
19996411-0	2010	Fluorinated per-acetylated GalNAc metabolically alters glycan structures on leukocyte PSGL-1 and reduces cell binding to selectins.	Polysaccharides	55-61	selectin P ligand	Homo sapiens	86-92
19996411-6	2010	4F-GalNAc was metabolically incorporated into PSGL-1, and this was accompanied by an approximately 20% reduction in PSGL-1 glycan content.	Polysaccharides	123-129	selectin P ligand	Homo sapiens	46-52
19996411-6	2010	4F-GalNAc was metabolically incorporated into PSGL-1, and this was accompanied by an approximately 20% reduction in PSGL-1 glycan content.	Polysaccharides	123-129	selectin P ligand	Homo sapiens	116-122
19846580-10	2010	When the N-linked asialo-agalacto-biantennary glycan acceptor was utilized with GnT-Vb, the expected triantennary beta1,6-branched product was observed up to 8 h incubation.	Polysaccharides	46-52	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B	Homo sapiens	80-86
20386661-1	2010	Phenolic esters have attracted considerable interest due to the potential they offer for peroxidase catalysed cross-linking of cell wall polysaccharides.	Polysaccharides	137-152	peroxidase 1	Zea mays	89-99
19768780-1	2010	Recently, we isolated and purified a neutral polysaccharide (PGN) from edible fungus Pleurotus geestanus.	Polysaccharides	45-59	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	61-64
20159460-0	2010	TPR motifs: hallmarks of a new polysaccharide export scaffold.	Polysaccharides	31-45	translocated promoter region, nuclear basket protein	Homo sapiens	0-3
20079654-1	2010	The glycan beta-galactosamine-(1-4)-3-O-methyl-D-chiro-inositol, called INS-2, was previously isolated from liver as a putative second messenger-modulator for insulin.	Polysaccharides	4-10	insulin 2	Rattus norvegicus	72-77
19800959-0	2010	Astragalus polysaccharide improves insulin sensitivity in KKAy mice: regulation of PKB/GLUT4 signaling in skeletal muscle.	Polysaccharides	11-25	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	87-92
20014858-0	2010	Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors.	Polysaccharides	59-65	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	53-58
19951949-6	2010	Binding studies using the solubilized LysM RLK1-yEGFP and several insoluble polysaccharides having similar structures showed that LysM RLK1-yEGFP specifically binds to chitin.	Polysaccharides	76-91	receptor-like protein kinase 1	Arabidopsis thaliana	135-139
19953551-10	2010	Results obtained from two of these glycoprotein markers, periostin and thrombospondin, have confirmed that tumor-specific glycan changes can be used to distinguish ovarian cancer patient serum from normal serum.	Polysaccharides	122-128	periostin	Homo sapiens	57-66
20018621-0	2010	Terminal deoxynucleotidyl transferase is required for an optimal response to the polysaccharide alpha-1,3 dextran.	Polysaccharides	81-95	deoxynucleotidyltransferase, terminal	Mus musculus	0-37
21731162-0	2010	Effect of Achyranthes bidentata polysaccharides on the expression of BCL-2 and bax in hepatic tissues after exhaustive exercise in rats.	Polysaccharides	32-47	BCL2, apoptosis regulator	Rattus norvegicus	69-74
21731162-0	2010	Effect of Achyranthes bidentata polysaccharides on the expression of BCL-2 and bax in hepatic tissues after exhaustive exercise in rats.	Polysaccharides	32-47	BCL2 associated X, apoptosis regulator	Rattus norvegicus	79-82
21061463-3	2010	This study was performed to investigate the effects of polysaccharides from cultivated fruiting bodies of C. militaris (CMP) on mitochondrial injury, antioxidation and anti-aging activity.	Polysaccharides	55-70	matrilin 1, cartilage matrix protein	Mus musculus	120-123
20673883-0	2010	Polysaccharide purified from Polyporus umbellatus (Per) Fr induces the activation and maturation of murine bone-derived dendritic cells via toll-like receptor 4.	Polysaccharides	0-14	toll-like receptor 4	Mus musculus	140-160
20930333-3	2010	HA is a natural polysaccharide already present in the articulations known to interact with the CD44 receptors of the cells (especially chondrocytes).	Polysaccharides	16-30	CD44 molecule (Indian blood group)	Rattus norvegicus	95-99
19931508-0	2010	Definitive evidence that a single N-glycan among three glycans on inducible costimulator is required for proper protein trafficking and ligand binding.	Polysaccharides	55-62	inducible T cell costimulator	Homo sapiens	66-88
19931508-4	2010	Here we demonstrate the integral involvement of a specific N-glycan from amongst the three glycans present on inducible costimulator (ICOS), a T-cell costimulatory molecule, in proper protein folding and intracellular trafficking to the cell surface membrane.	Polysaccharides	91-98	inducible T cell costimulator	Homo sapiens	110-132
19931508-4	2010	Here we demonstrate the integral involvement of a specific N-glycan from amongst the three glycans present on inducible costimulator (ICOS), a T-cell costimulatory molecule, in proper protein folding and intracellular trafficking to the cell surface membrane.	Polysaccharides	91-98	inducible T cell costimulator	Homo sapiens	134-138
20622461-5	2010	In addition, treating with the sulfated polysaccharides increased the nitric oxide (NO) and cytokine (IL-1beta and TNF-alpha) release to levels comparable to those detected in the positive control, lipopolysaccharide (LPS), suggesting that the sulfated polysaccharides might have strong immunomodulatory activity.	Polysaccharides	40-55	interleukin 1 beta	Homo sapiens	102-110
20622461-5	2010	In addition, treating with the sulfated polysaccharides increased the nitric oxide (NO) and cytokine (IL-1beta and TNF-alpha) release to levels comparable to those detected in the positive control, lipopolysaccharide (LPS), suggesting that the sulfated polysaccharides might have strong immunomodulatory activity.	Polysaccharides	40-55	tumor necrosis factor	Homo sapiens	115-124
19736239-6	2010	Interestingly, it appears that the glycan structures on glycoproteins and glycolipids, expressed in healing corneas as a result of differential regulation of these glycosyltransferases, may serve as specific counter-receptors for galectin-3, a carbohydrate-binding protein, known to play a key role in re-epithelialization of corneal wounds.	Polysaccharides	35-41	lectin, galactose binding, soluble 3	Mus musculus	230-240
20034698-0	2010	DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools.	Polysaccharides	22-29	CD209 molecule	Homo sapiens	0-7
20034698-0	2010	DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools.	Polysaccharides	22-29	collectin subfamily member 12	Homo sapiens	12-16
20034698-0	2010	DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools.	Polysaccharides	22-29	CEA cell adhesion molecule 5	Homo sapiens	59-62
19741058-0	2010	Characterization of gene-activated human acid-beta-glucosidase: crystal structure, glycan composition, and internalization into macrophages.	Polysaccharides	83-89	glucosylceramidase beta	Homo sapiens	41-62
20008963-0	2010	A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart.	Polysaccharides	2-16	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	18-23
20008963-0	2010	A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart.	Polysaccharides	2-16	sphingosine-1-phosphate receptor 1	Homo sapiens	33-37
20008963-0	2010	A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart.	Polysaccharides	2-16	fibroblast growth factor 2	Homo sapiens	42-46
19741058-9	2010	The predominant glycan on velaglucerase alfa is a high-mannose type, with nine mannose units, while imiglucerase contains a chitobiose tri-mannosyl core glycan with fucosylation.	Polysaccharides	153-159	glucosylceramidase beta	Homo sapiens	100-112
19826404-2	2010	Here we pursued to promote regeneration after thoracic spinal cord injury in young adult C57BL/6J mice using peptides which functionally mimic polysialic acid (PSA) and human natural killer cell-1 (HNK-1) glycan, carbohydrate epitopes known to promote neurite outgrowth in vitro.	Polysaccharides	205-211	beta-1,3-glucuronyltransferase 1	Homo sapiens	198-203
19637375-4	2010	Heparin and fragmin enhanced SCF-induced proliferation of chlorate-treated TF-1 cells, in which the biosynthesis of endogenous sulfated polysaccharides was blocked, on noncoated plates at a range of concentrations (2-8 microg/mL).	Polysaccharides	136-151	KIT ligand	Homo sapiens	29-32
20981146-5	2010	Importantly, Dpl exhibited different cellular localizations and altered glycan moieties composition, depending on the tumor grade.	Polysaccharides	72-78	prion like protein doppel	Homo sapiens	13-16
19899825-5	2010	Additionally, we characterized alterations in the glycan structures of vitronectin (Asn-169, 242) and antithrombin III (Asn-225) that were identified in HCC patient plasma.	Polysaccharides	50-56	vitronectin	Homo sapiens	71-82
20816161-6	2010	This chapter describes a method called "glycosyltransferase-programmed stereosubstitution" (GPS) for custom-modifying CD44 glycans to create HCELL on the surface of living cells that natively lack HCELL.	Polysaccharides	123-130	CD44 molecule (Indian blood group)	Homo sapiens	118-122
20816161-7	2010	Ex vivo glycan engineering of HCELL via GPS licenses trafficking of infused cells to endothelial beds that express E-selectin, thereby enabling efficient vascular delivery of stem/progenitor cells to sites where they are needed.	Polysaccharides	8-14	selectin E	Homo sapiens	115-125
20816167-4	2010	Flow cytometry, LEL lectin-blotting, and glycan analysis by metabolic labeling demonstrated that the amount of polylactosamine chains on N-glycans was greatly reduced in the tissues of B3gnt2-/- mice.	Polysaccharides	41-47	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Mus musculus	185-191
20816171-4	2010	Because mucin-type O-glycans present sialyl Lewis X (sLeX) and sulfated version of the glycans, which are L-selectin ligands, at the reducing end, the amounts of the ligands of these knockout mice would be reduced.	Polysaccharides	21-28	selectin, lymphocyte	Mus musculus	106-116
19897484-2	2010	Experiments in this report indicate that BCL10 is required for activation of nuclear factor (NF)-kappaB by both canonical and noncanonical pathways, following stimulation by the sulfated polysaccharide carrageenan (CGN).	Polysaccharides	187-201	BCL10 immune signaling adaptor	Homo sapiens	41-46
19711151-7	2010	We obtained 2 polysaccharide fractions, IA-a and IA-b, which potently stimulated cytokine production.	Polysaccharides	14-28	protein tyrosine phosphatase, receptor type, N	Mus musculus	40-44
20816484-6	2010	GBP binding assays on glycan microarrays will provide only partial information about the specificity and high-affinity ligands for those GBPs.	Polysaccharides	22-28	galectin 1	Homo sapiens	0-3
19796667-1	2009	The human natural killer-1 (HNK-1) glyco-epitope possesses a unique structural feature, a sulfated glucuronic acid attached to lactosamine on the non-reducing termini of glycans.	Polysaccharides	170-177	beta-1,3-glucuronyltransferase 1	Homo sapiens	28-33
20134191-5	2010	Together with the ability of galectin-1-glycan interactions to selectively blunt T helper (Th)1 and Th17 responses, this effect provides a rational explanation for the broad immunosuppressive effects of this glycan-binding protein in several experimental models of chronic inflammation and cancer.	Polysaccharides	40-46	galectin 1	Homo sapiens	29-39
20044950-3	2009	The polysaccharide significantly inhibited (P 0.01) LPS-induced iNOS and COX-2 expression levels in the cells.	Polysaccharides	4-18	nitric oxide synthase 2, inducible	Mus musculus	64-68
20044950-3	2009	The polysaccharide significantly inhibited (P 0.01) LPS-induced iNOS and COX-2 expression levels in the cells.	Polysaccharides	4-18	prostaglandin-endoperoxide synthase 2	Mus musculus	73-78
20044950-5	2009	These results suggest that this polysaccharide may be used for NO- and COX-2-related disorders such as inflammation and cancer.	Polysaccharides	32-46	prostaglandin-endoperoxide synthase 2	Mus musculus	71-76
19801653-1	2009	The specificity of the cation-independent and -dependent mannose 6-phosphate receptors (CI-MPR and CD-MPR) for high mannose-type N-glycans of defined structure containing zero, one, or two Man-P-GlcNAc phosphodiester or Man-6-P phosphomonoester residues was determined by analysis on a phosphorylated glycan microarray.	Polysaccharides	131-137	mannose-6-phosphate receptor, cation dependent	Homo sapiens	99-105
19836729-0	2009	Action of beta-galactosidase in medium on the Lemna minor (L.) callus polysaccharides.	Polysaccharides	70-85	galactosidase beta 1	Homo sapiens	10-28
19836729-1	2009	The callus culture of duckweed cultivated on medium containing different concentrations of beta-galactosidase was shown to produce the following polysaccharides: pectin lemnan LMC, intracellular AG1, and extracellular AG2 arabinogalactans.	Polysaccharides	145-160	galactosidase beta 1	Homo sapiens	91-109
19801653-1	2009	The specificity of the cation-independent and -dependent mannose 6-phosphate receptors (CI-MPR and CD-MPR) for high mannose-type N-glycans of defined structure containing zero, one, or two Man-P-GlcNAc phosphodiester or Man-6-P phosphomonoester residues was determined by analysis on a phosphorylated glycan microarray.	Polysaccharides	131-137	insulin like growth factor 2 receptor	Homo sapiens	88-94
19801653-4	2009	The CD-MPR bound weakly or undetectably to the phosphodiester derivatives, but strongly to the phosphomonoester-containing glycans with the exception of a single Man7GlcNAc2-R isomer that contained a single Man-6-P residue.	Polysaccharides	123-130	mannose-6-phosphate receptor, cation dependent	Homo sapiens	4-10
19801653-5	2009	By contrast, the CI-MPR bound with high affinity to glycans containing either phospho-mono- or -diesters although, like the CD-MPR, it differentially recognized isomers of phosphorylated Man7GlcNAc2-R.	Polysaccharides	52-59	insulin like growth factor 2 receptor	Homo sapiens	17-23
19801653-5	2009	By contrast, the CI-MPR bound with high affinity to glycans containing either phospho-mono- or -diesters although, like the CD-MPR, it differentially recognized isomers of phosphorylated Man7GlcNAc2-R.	Polysaccharides	52-59	mannose-6-phosphate receptor, cation dependent	Homo sapiens	124-130
20044600-5	2009	However, the MLs only slightly modified the MRP5 efflux pump, while periodate treatment to inhibit cell membrane binding via glycan completely abolished the ML-I binding sites in MRP5 overexpressing cells.	Polysaccharides	125-131	ATP binding cassette subfamily C member 5	Homo sapiens	179-183
19840944-2	2009	To determine the types of phosphorylated N-glycans recognized by each of the three carbohydrate binding sites of the CI-MPR, a phosphorylated glycan microarray was probed with truncated forms of the CI-MPR.	Polysaccharides	43-49	insulin like growth factor 2 receptor	Homo sapiens	117-123
20054124-0	2009	Crystallization and preliminary X-ray diffraction studies of the carbohydrate-recognition domain of SIGN-R1, a receptor for microbial polysaccharides and sialylated antibody on splenic marginal zone macrophages.	Polysaccharides	134-149	CD209b antigen	Mus musculus	100-107
20054124-2	2009	SIGN-R1 can bind and mediate the uptake of various microbial polysaccharides, including dextrans, lipopolysaccharides and pneumococcal capsular polysaccharides.	Polysaccharides	61-76	CD209b antigen	Mus musculus	0-7
19733219-5	2009	The N-glycans obtained from rat brain ICAM-5 consisted of approximately 85% neutral, 10.2% sialylated-only, 2.8% sulfated-only, and 1.2% sialylated and sulfated glycans.	Polysaccharides	6-13	intercellular adhesion molecule 5	Rattus norvegicus	38-44
19733219-6	2009	Compared with the N-glycan structures of human ICAM-1 expressed in CHO cells, HEK cells, or mouse myeloma cells and ICAM-3 isolated from human T-cells, rat brain ICAM-5 had less highly branched glycans, sialylated glycans, and N-acetyllactosamine structures.	Polysaccharides	194-201	intercellular adhesion molecule 5	Rattus norvegicus	162-168
19542522-3	2009	The monoglucosylated glycan produced by the first GluII trimming reaction is recognized by calnexin/calreticulin and serves as the signal for entry into this folding pathway.	Polysaccharides	21-27	calnexin	Saccharomyces cerevisiae S288C	91-99
19326211-4	2009	Epithelial cells in vaginal lavages from Fut2-null mice lacked Ulex europaeus agglutinin-1 (UEA-I) staining for alpha(1-2)fucosylated glycans.	Polysaccharides	134-141	fucosyltransferase 2	Mus musculus	41-45
19326211-10	2009	While a small portion of the recombinant MUC1 epitopes displayed alpha(1-2)fucosylated glycans, the predominant epitopes were sialylated due to endogenous sialyltransferases in the cultured cells.	Polysaccharides	87-94	mucin 1, transmembrane	Mus musculus	41-45
19928816-2	2009	Resilin binds to the cuticle polysaccharide chitin via a chitin binding domain and is further polymerized through oxidation of the tyrosine residues resulting in the formation of dityrosine bridges and assembly of a high-performance protein--carbohydrate composite material.	Polysaccharides	29-43	resilin	Drosophila melanogaster	0-7
19681908-3	2009	MGL receptor binding was abrogated by EDTA and N-acetylgalactosamine (GalNAc) and was successfully transferred to Escherichia coli by introducing the C. jejuni pgl locus together with a glycan acceptor protein.	Polysaccharides	186-192	C-type lectin domain containing 10A	Homo sapiens	0-3
19689471-0	2009	Ability of the polysaccharide chitosan to inhibit proliferation of CD4+ lymphocytes from mucosal inductive sites, in vitro and in vivo.	Polysaccharides	15-29	Cd4 molecule	Rattus norvegicus	67-70
19430902-6	2009	The amount of trisialylated glycans on gp96 and HSP65 and monosialylated glycans on grp75 of regressing cells was significantly lower than in progressively growing cells, suggesting a dependency of these specific glycoforms on anti-tumor immunity.	Polysaccharides	28-35	heat shock protein 90, beta (Grp94), member 1	Mus musculus	39-43
19430902-6	2009	The amount of trisialylated glycans on gp96 and HSP65 and monosialylated glycans on grp75 of regressing cells was significantly lower than in progressively growing cells, suggesting a dependency of these specific glycoforms on anti-tumor immunity.	Polysaccharides	73-80	heat shock protein 9	Mus musculus	84-89
19326211-11	2009	Intravaginal instillation of recombinant MUC1 glycanpolymer partially reduced experimental yeast vaginitis suggesting that a large glycanpolymer, with different glycan epitopes, may affect fungal burden.	Polysaccharides	46-52	Flo11p	Saccharomyces cerevisiae S288C	41-45
19357989-1	2009	Glycogen storage disease type IV (GSD IV, or Andersen disease) is an autosomal recessive disorder due to the deficiency of 1,4-alpha-glucan branching enzyme (or glycogen branching enzyme, GBE1), resulting in an accumulation of amylopectin-like polysaccharide in muscle, liver, heart and central and peripheral nervous system.	Polysaccharides	244-258	1,4-alpha-glucan branching enzyme 1	Homo sapiens	188-192
19643959-2	2009	In an effort to understand why the injured corneas of Gal-3(-/-) mice are unresponsive to exogenous Gal-3, the present study was designed to determine whether genes encoding the enzymes that regulate the synthesis of glycan ligands of Gal-3 are differentially expressed in Gal-3(-/-) corneas compared with the Gal-3(+/+) corneas.	Polysaccharides	217-223	lectin, galactose binding, soluble 3	Mus musculus	54-59
19643959-8	2009	CONCLUSIONS: Based on the known functions of the differentially expressed glycogenes, it appears that the glycan structures on glycoproteins and glycolipids, synthesized as a result of the differential glycogene expression pattern in healing Gal-3(-/-) corneas may lead to the downregulation of specific counterreceptors for Gal-3.	Polysaccharides	106-112	lectin, galactose binding, soluble 3	Mus musculus	242-247
19643959-8	2009	CONCLUSIONS: Based on the known functions of the differentially expressed glycogenes, it appears that the glycan structures on glycoproteins and glycolipids, synthesized as a result of the differential glycogene expression pattern in healing Gal-3(-/-) corneas may lead to the downregulation of specific counterreceptors for Gal-3.	Polysaccharides	106-112	lectin, galactose binding, soluble 3	Mus musculus	325-330
19506293-9	2009	The method was applied to mass spectrometric data of normal human monocytes and monocytic leukemia (THP1) cells to derive glycosyltransferase activity changes underlying the differences in glycan structure between the normal and diseased cells.	Polysaccharides	189-195	GLI family zinc finger 2	Homo sapiens	100-104
19818504-9	2009	Thus, we conclude that glycan modification of antigens and targeting to DC-SIGN enhance both CD4 and CD8 T cell responses.	Polysaccharides	23-29	CD4 antigen	Mus musculus	93-96
19832797-7	2009	Heat-killed P. gingivalis stimulated SR-A expression similar to live bacteria, and purified P. gingivalis capsular polysaccharide stimulated macrophage SR-A expression, indicating that live whole organisms are not necessary for SR-A protein expression in macrophage response.	Polysaccharides	115-129	macrophage scavenger receptor 1	Mus musculus	152-156
19832797-7	2009	Heat-killed P. gingivalis stimulated SR-A expression similar to live bacteria, and purified P. gingivalis capsular polysaccharide stimulated macrophage SR-A expression, indicating that live whole organisms are not necessary for SR-A protein expression in macrophage response.	Polysaccharides	115-129	macrophage scavenger receptor 1	Mus musculus	152-156
20023196-5	2009	Here, we show that loss-of-function mutations in the Arabidopsis thaliana homolog of the yeast ALG12 result in transfer of incompletely assembled glycans to polypeptides.	Polysaccharides	146-153	dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase	Saccharomyces cerevisiae S288C	95-100
19706343-2	2009	beta2GPI is N-glycosylated at several asparagine residues and the glycan moiety conjugated to residue 143 has been proposed to interact with the Gly40-Arg43 motif of beta2GPI.	Polysaccharides	66-72	apolipoprotein H	Homo sapiens	0-8
19706343-2	2009	beta2GPI is N-glycosylated at several asparagine residues and the glycan moiety conjugated to residue 143 has been proposed to interact with the Gly40-Arg43 motif of beta2GPI.	Polysaccharides	66-72	apolipoprotein H	Homo sapiens	166-174
19706343-4	2009	We hypothesized that the structure or composition of the glycan at Asn-143 might be associated with the APS symptom by shielding or exposing the Gly40-Arg43 motif towards the anti-beta2GPI autoantibody.	Polysaccharides	57-63	apolipoprotein H	Homo sapiens	180-188
19706343-9	2009	These data indicate that some APS patients have beta2GPI molecules with a reduced number of negatively charged sialic acid units in the glycan structure at Asn-143.	Polysaccharides	136-142	apolipoprotein H	Homo sapiens	48-56
19706343-10	2009	This alteration of the electrostatic properties of the glycan moiety may attenuate the intramolecular interactions with the positively charged Gly40-Arg43 motif of beta2GPI and, in turn, leads to conformational instability and exposure of the disease-related linear epitope Gly40-Arg43 to the circulating autoantibody.	Polysaccharides	55-61	apolipoprotein H	Homo sapiens	164-172
19706343-11	2009	Thus, our study suggests a link between site-specific glycan profiles of beta2GPI and the pathology of antiphospholipid syndrome.	Polysaccharides	54-60	apolipoprotein H	Homo sapiens	73-81
19721061-0	2009	The phthalocyanine prototype derivative Alcian Blue is the first synthetic agent with selective anti-human immunodeficiency virus activity due to its gp120 glycan-binding potential.	Polysaccharides	156-162	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	150-155
20037295-1	2009	PSK, a protein-bound polysaccharide, is widely used for treating cancer patients as an immunostimulant.	Polysaccharides	21-35	TAO kinase 2	Homo sapiens	0-3
19732381-5	2009	Mutation of LEW3 caused low-level accumulation of Man(3)GlcNAc(2) and Man(4)GlcNAc(2) glycans, structures that are seldom detected in wild-type plants.	Polysaccharides	86-93	UDP-Glycosyltransferase superfamily protein	Arabidopsis thaliana	12-16
19732381-6	2009	In addition, the lew3 mutant has low levels of normal high-mannose-type glycans, but increased levels of complex-type glycans.	Polysaccharides	72-79	UDP-Glycosyltransferase superfamily protein	Arabidopsis thaliana	17-21
19732381-6	2009	In addition, the lew3 mutant has low levels of normal high-mannose-type glycans, but increased levels of complex-type glycans.	Polysaccharides	118-125	UDP-Glycosyltransferase superfamily protein	Arabidopsis thaliana	17-21
19783858-4	2009	Employing a tagging strategy that used insertion of ectopic glycan attachment sites and terminal fusions of green fluorescent protein, we established a five-transmembrane model, thus dividing LMF1 into six domains.	Polysaccharides	60-66	lipase maturation factor 1	Homo sapiens	192-196
19751718-4	2009	glf-1 mutants display significant late embryonic and larval lethality, and other phenotypes indicative of defective surface coat synthesis, the glycan-rich outermost layer of the nematode cuticle.	Polysaccharides	144-150	Amino_oxidase domain-containing protein	Caenorhabditis elegans	0-5
19751718-6	2009	glf-1 mutants rescued by L. major glf, which behave as glf-1 hypomorphs, display resistance to infection by Microbacterium nematophilum, a pathogen of rhabditid nematodes thought to bind to surface coat glycans.	Polysaccharides	203-210	Amino_oxidase domain-containing protein	Caenorhabditis elegans	0-5
19915667-1	2009	BACKGROUND: Dectin-1 is a pattern recognition receptor (PRR) expressed by myeloid cells that specifically recognizes beta-1,3 glucan, a polysaccharide and major component of the fungal cell wall.	Polysaccharides	136-150	C-type lectin domain containing 7A	Homo sapiens	12-20
19915667-1	2009	BACKGROUND: Dectin-1 is a pattern recognition receptor (PRR) expressed by myeloid cells that specifically recognizes beta-1,3 glucan, a polysaccharide and major component of the fungal cell wall.	Polysaccharides	136-150	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	117-125
19902125-9	2009	Further comprehensive bioinformatics analysis revealed that the secretory proteins in extracellular matrix-receptor interaction pathway and glycan structure degradation pathway were significantly upregulated by insulin stimulation.	Polysaccharides	140-146	insulin	Homo sapiens	211-218
19923712-8	2009	Complexes of GP with an antibody fragment (Fab) promoted crystallization and a series of deglycosylation strategies, including sugar mutants, enzymatic deglycosylation, insect-cell expression and glycan anabolic pathway inhibitors, were attempted to improve the weakly diffracting glycoprotein crystals.	Polysaccharides	196-202	FA complementation group B	Homo sapiens	43-46
19665434-7	2009	The latter cells also expressed higher levels of PSGL-1 modified by P-selectin glycan ligands; C2GlcNAcT-1 mRNA, a glycosyltransferase critical for such glycan synthesis; and more uniformly bound to P-selectin.	Polysaccharides	79-85	selectin P ligand	Homo sapiens	49-55
19734368-0	2009	Two novel techniques for determination of polysaccharide cross-links show that Crh1p and Crh2p attach chitin to both beta(1-6)- and beta(1-3)glucan in the Saccharomyces cerevisiae cell wall.	Polysaccharides	42-56	transglycosylase	Saccharomyces cerevisiae S288C	79-84
19734368-0	2009	Two novel techniques for determination of polysaccharide cross-links show that Crh1p and Crh2p attach chitin to both beta(1-6)- and beta(1-3)glucan in the Saccharomyces cerevisiae cell wall.	Polysaccharides	42-56	Utr2p	Saccharomyces cerevisiae S288C	89-94
19722277-1	2009	Two structurally-related members of the lysosomal mannosidase family, the broad substrate specificity enzyme human lysosomal alpha-mannosidase (hLM, MAN2B1) and the human core alpha-1, 6-specific mannosidase (hEpman, MAN2B2) act in a complementary fashion on different glycosidic linkages, to effect glycan degradation in the lysosome.	Polysaccharides	300-306	oxysterol binding protein 2	Homo sapiens	144-147
19874043-3	2009	In the present study, two new water-soluble polysaccharides, named LSP1 and LSP2, were isolated from the active crude polysaccharides by DEAE-cellulose 52 and AB-8 macroporous resin chromatography and tested for their hypoglycemic effects.	Polysaccharides	44-59	lymphocyte specific 1	Mus musculus	67-71
19874043-3	2009	In the present study, two new water-soluble polysaccharides, named LSP1 and LSP2, were isolated from the active crude polysaccharides by DEAE-cellulose 52 and AB-8 macroporous resin chromatography and tested for their hypoglycemic effects.	Polysaccharides	118-133	lymphocyte specific 1	Mus musculus	67-71
19605906-6	2009	Abnormal polysaccharide was fine granular or homogenous in appearance (49/53; 92%), often amylase-sensitive (28/53; 53%), more commonly located under the sarcolemma, and consisting of beta glycogen particles in GYS1-negative horses.	Polysaccharides	9-23	glycogen synthase 1	Equus caballus	211-215
19605906-7	2009	However, in GYS1-positive horses, abnormal polysaccharide was usually coarse granular (50/52; 96%), amylase-resistant (51/52; 98%), more commonly cytoplasmic, and consisting of beta glycogen particles or, in some myofibers, filamentous material surrounded by beta glycogen particles.	Polysaccharides	43-57	glycogen synthase 1	Equus caballus	12-16
20209965-4	2009	RESULT: Total alkaloids of Radix Aconiti Praeparata and total glycosides or polysaccharides of Radix Paeoniae Alba could relieve arthrocele and arthralgia and elevate the contents of L-ENK, beta-END, IL-2 and degrade the contents of SP, IgG, IL-1beta, IL-6 and inhibit abnormal secretion accentuation of synovial cell like fiber.	Polysaccharides	76-91	interleukin 2	Rattus norvegicus	200-204
20095431-0	2009	[Effect of recombinant heat-shock protein (rHSP70) of Mycobacterium tuberculosis on immunogenicity of Haemophilus influenzae type B capsular polysaccharide].	Polysaccharides	141-155	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	43-49
20095431-1	2009	AIM: To study effect of recombinant heat-shock protein (rHSP70) of Mycobacterium tuberculosis on immunogenicity of Haemophilus influenzae type b capsular polysaccharide (CPSHib).	Polysaccharides	154-168	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	56-62
20209965-4	2009	RESULT: Total alkaloids of Radix Aconiti Praeparata and total glycosides or polysaccharides of Radix Paeoniae Alba could relieve arthrocele and arthralgia and elevate the contents of L-ENK, beta-END, IL-2 and degrade the contents of SP, IgG, IL-1beta, IL-6 and inhibit abnormal secretion accentuation of synovial cell like fiber.	Polysaccharides	76-91	interleukin 1 beta	Rattus norvegicus	242-250
20209965-4	2009	RESULT: Total alkaloids of Radix Aconiti Praeparata and total glycosides or polysaccharides of Radix Paeoniae Alba could relieve arthrocele and arthralgia and elevate the contents of L-ENK, beta-END, IL-2 and degrade the contents of SP, IgG, IL-1beta, IL-6 and inhibit abnormal secretion accentuation of synovial cell like fiber.	Polysaccharides	76-91	interleukin 6	Rattus norvegicus	252-256
19729452-1	2009	HNK-1 (human natural killer-1) glyco-epitope, a sulfated glucuronic acid attached to N-acetyllactosamine on the nonreducing termini of glycans, is highly expressed in the nervous system.	Polysaccharides	135-142	beta-1,3-glucuronyltransferase 1	Homo sapiens	0-5
19729452-4	2009	We demonstrated that the HNK-1 epitope is specifically expressed on the N-linked glycan(s) on GluR2 among the glutamate receptors tested, and the glycan structure, including HNK-1 on GluR2, was determined using liquid chromatography-tandem mass spectrometry.	Polysaccharides	81-87	beta-1,3-glucuronyltransferase 1	Homo sapiens	25-30
19729452-4	2009	We demonstrated that the HNK-1 epitope is specifically expressed on the N-linked glycan(s) on GluR2 among the glutamate receptors tested, and the glycan structure, including HNK-1 on GluR2, was determined using liquid chromatography-tandem mass spectrometry.	Polysaccharides	81-87	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	94-99
19729452-4	2009	We demonstrated that the HNK-1 epitope is specifically expressed on the N-linked glycan(s) on GluR2 among the glutamate receptors tested, and the glycan structure, including HNK-1 on GluR2, was determined using liquid chromatography-tandem mass spectrometry.	Polysaccharides	81-87	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	183-188
19230844-4	2009	The secreted Klotho protein has a putative sialidase activity that modifies glycans on the cell surface, which may explain the ability of secreted Klotho protein to regulate activity of multiple ion channels and growth factors including insulin, IGF-1, and Wnt.	Polysaccharides	76-83	klotho	Mus musculus	13-19
19704115-0	2009	ABO blood group glycans modulate sialic acid recognition on erythrocytes.	Polysaccharides	16-23	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	0-15
19704115-1	2009	ABH(O) blood group polymorphisms are based on well-known intraspecies variations in structures of neutral blood cell surface glycans in humans and other primates.	Polysaccharides	125-132	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	0-3
19704115-4	2009	We show in this study that ABH antigens found on human erythrocytes modulate the specific interactions of 3 sialic acid-recognizing proteins (human Siglec-2, 1918SC influenza hemagglutinin, and Sambucus nigra agglutinin) with sialylated glycans on the same cell surface.	Polysaccharides	237-244	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	27-30
19704115-5	2009	Using specific glycosidases that convert A and B glycans to the underlying H(O) structure, we show ABH antigens stabilize sialylated glycan clusters on erythrocyte membranes uniquely for each blood type, generating differential interactions of the 3 sialic acid-binding proteins with erythrocytes from each blood type.	Polysaccharides	49-56	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	99-102
19704115-5	2009	Using specific glycosidases that convert A and B glycans to the underlying H(O) structure, we show ABH antigens stabilize sialylated glycan clusters on erythrocyte membranes uniquely for each blood type, generating differential interactions of the 3 sialic acid-binding proteins with erythrocytes from each blood type.	Polysaccharides	49-55	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	99-102
19704115-7	2009	Thus, ABH antigens can noncovalently alter the presentation of other cell surface glycans to cognate-binding proteins, without themselves being a direct ligand.	Polysaccharides	82-89	alkB homolog 1, histone H2A dioxygenase	Homo sapiens	6-9
19837036-5	2009	PGAP5 belongs to a dimetal-containing phosphoesterase family and catalyzed the remodeling of the glycan moiety on GPI-APs.	Polysaccharides	97-103	metallophosphoesterase 1	Homo sapiens	0-5
19837036-7	2009	Our data demonstrate that GPI glycan acts as an ER-exit signal and suggest that glycan remodeling mediated by PGAP5 regulates GPI-AP transport in the early secretory pathway.	Polysaccharides	30-36	metallophosphoesterase 1	Homo sapiens	110-115
19739208-5	2009	Glycans attached to hyp would be expected to be projected from the opposite face of the prolyl side chain relative to Hyp; the impact this would have on K(trans/cis) was unknown.	Polysaccharides	0-7	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	20-23
19739208-5	2009	Glycans attached to hyp would be expected to be projected from the opposite face of the prolyl side chain relative to Hyp; the impact this would have on K(trans/cis) was unknown.	Polysaccharides	0-7	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	118-121
19739208-9	2009	Because the different stereoisomers--Hyp and hyp--project the O-linked carbohydrates in opposite spatial orientations, these glycosylated amino acids may be useful for understanding of how the projection of a glycan from the peptide or protein backbone exerts its influence.	Polysaccharides	209-215	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	37-40
19898805-4	2009	Furthermore, PMB and PPO were two principal components of polysaccharides elevating brain 5-HT levels.	Polysaccharides	58-73	protoporphyrinogen oxidase	Mus musculus	21-24
19760718-3	2009	We had revealed that one helix-forming natural polysaccharide (SPG) and one polythiophene derivative (PT-1) formed a stable one-dimensional complex and in the polythiophene main chain a helical conformation was induced through the dynamic conformational changes.	Polysaccharides	47-61	zinc finger protein 77	Homo sapiens	102-106
19690161-9	2009	We tested the hypothesis that the Asn-89 complex glycan of vIL-6 alone was sufficient to confer binding to gp130 independently of IL-6Ralpha.	Polysaccharides	49-55	interleukin 6 cytokine family signal transducer	Homo sapiens	107-112
19690161-11	2009	Our findings support the conclusion that complex glycans on Asn-89 of vIL-6 specifically promote a protein conformation that allows the viral cytokine to bind gp130 independently of IL-6Ralpha.	Polysaccharides	49-56	interleukin 6 cytokine family signal transducer	Homo sapiens	159-164
19690161-11	2009	Our findings support the conclusion that complex glycans on Asn-89 of vIL-6 specifically promote a protein conformation that allows the viral cytokine to bind gp130 independently of IL-6Ralpha.	Polysaccharides	49-56	interleukin 6 receptor	Homo sapiens	182-192
19772356-0	2009	Branch-specific sialylation of IgG-Fc glycans by ST6Gal-I.	Polysaccharides	38-45	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	49-57
19755493-7	2009	Experiments involving knockdown of beta-1,6-N-acetylglucosaminytransferase V, an enzyme that synthesizes high-affinity glycan ligands for Gal-3, revealed that carbohydrate-mediated interaction between Gal-3 and complex N-glycans on alpha3beta1 integrin plays a key role in Gal-3-induced lamellipodia formation.	Polysaccharides	119-125	galectin 3	Homo sapiens	138-143
19755493-7	2009	Experiments involving knockdown of beta-1,6-N-acetylglucosaminytransferase V, an enzyme that synthesizes high-affinity glycan ligands for Gal-3, revealed that carbohydrate-mediated interaction between Gal-3 and complex N-glycans on alpha3beta1 integrin plays a key role in Gal-3-induced lamellipodia formation.	Polysaccharides	119-125	galectin 3	Homo sapiens	201-206
19755493-7	2009	Experiments involving knockdown of beta-1,6-N-acetylglucosaminytransferase V, an enzyme that synthesizes high-affinity glycan ligands for Gal-3, revealed that carbohydrate-mediated interaction between Gal-3 and complex N-glycans on alpha3beta1 integrin plays a key role in Gal-3-induced lamellipodia formation.	Polysaccharides	119-125	galectin 3	Homo sapiens	201-206
19739208-9	2009	Because the different stereoisomers--Hyp and hyp--project the O-linked carbohydrates in opposite spatial orientations, these glycosylated amino acids may be useful for understanding of how the projection of a glycan from the peptide or protein backbone exerts its influence.	Polysaccharides	209-215	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	45-48
19805031-2	2009	Zwitterionic polysaccharides (ZPS), obtained through chemical introduction of positive charges into anionic polysaccharides (PS) from GBS, have the ability to activate human and mouse antigen presenting cells (APCs) through toll-like receptor 2 (TLR2).	Polysaccharides	13-28	toll like receptor 2	Homo sapiens	224-244
19805031-2	2009	Zwitterionic polysaccharides (ZPS), obtained through chemical introduction of positive charges into anionic polysaccharides (PS) from GBS, have the ability to activate human and mouse antigen presenting cells (APCs) through toll-like receptor 2 (TLR2).	Polysaccharides	13-28	toll like receptor 2	Homo sapiens	246-250
19805031-2	2009	Zwitterionic polysaccharides (ZPS), obtained through chemical introduction of positive charges into anionic polysaccharides (PS) from GBS, have the ability to activate human and mouse antigen presenting cells (APCs) through toll-like receptor 2 (TLR2).	Polysaccharides	31-33	toll like receptor 2	Homo sapiens	224-244
19805031-2	2009	Zwitterionic polysaccharides (ZPS), obtained through chemical introduction of positive charges into anionic polysaccharides (PS) from GBS, have the ability to activate human and mouse antigen presenting cells (APCs) through toll-like receptor 2 (TLR2).	Polysaccharides	31-33	toll like receptor 2	Homo sapiens	246-250
19230844-4	2009	The secreted Klotho protein has a putative sialidase activity that modifies glycans on the cell surface, which may explain the ability of secreted Klotho protein to regulate activity of multiple ion channels and growth factors including insulin, IGF-1, and Wnt.	Polysaccharides	76-83	klotho	Mus musculus	147-153
21083053-2	2009	C18, graphitized carbon and amide-based stationary phases were adapted to nanoflow level and on chip format, leading to improved sensitivity of structural analysis and superior level of information on highly complex glycan and glycoconjugate mixtures.	Polysaccharides	216-222	Bardet-Biedl syndrome 9	Homo sapiens	0-3
19230844-4	2009	The secreted Klotho protein has a putative sialidase activity that modifies glycans on the cell surface, which may explain the ability of secreted Klotho protein to regulate activity of multiple ion channels and growth factors including insulin, IGF-1, and Wnt.	Polysaccharides	76-83	insulin-like growth factor 1	Mus musculus	246-251
19935886-0	2009	Gene SMb21071 of plasmid pSymB is required for osmoadaptation of Sinorhizobium meliloti 1021 and is implicated in modifications of cell surface polysaccharides structure in response to hyperosmotic stress.	Polysaccharides	144-159	exopolysaccharide biosynthesis protein	Sinorhizobium meliloti 1021	5-13
19571171-2	2009	Here, we report the sites at which GlcNAc6ST-1 is modified with N-linked glycans and the effects that each glycan has on enzyme activity, specificity, and localization.	Polysaccharides	73-79	carbohydrate sulfotransferase 2	Homo sapiens	35-46
19608407-3	2009	Through sugar-specific interactions with glycan-binding proteins on apposing cells, gangliosides function as receptors in cell-cell recognition, regulating natural killer cell cytotoxicity via Siglec-7, myelin-axon interactions via Siglec-4 (myelin-associated glycoprotein), and inflammation via E-selectin.	Polysaccharides	41-47	myelin associated glycoprotein	Homo sapiens	242-272
19608407-3	2009	Through sugar-specific interactions with glycan-binding proteins on apposing cells, gangliosides function as receptors in cell-cell recognition, regulating natural killer cell cytotoxicity via Siglec-7, myelin-axon interactions via Siglec-4 (myelin-associated glycoprotein), and inflammation via E-selectin.	Polysaccharides	41-47	selectin E	Homo sapiens	296-306
19625484-6	2009	Here, we demonstrate that human GIIbeta-MRH binds to high-mannose-type glycans.	Polysaccharides	71-78	protein kinase C substrate 80K-H	Homo sapiens	32-39
21048648-8	2009	RESULTS: Compared with the I/R group, YLS polysaccharide reduced the neurological score, the brain water content, the infract volume, MDA and NO contents, the NOS activity, and the expression of Bax, and increased SOD activity, and the expression of Bcl-2 in the brain tissue, and neuronal edema was reduced.	Polysaccharides	42-56	BCL2 associated X, apoptosis regulator	Rattus norvegicus	195-198
19625484-7	2009	Frontal affinity chromatography revealed that GIIbeta-MRH binds most strongly to the glycans with the alpha1,2-linked mannobiose structure.	Polysaccharides	85-92	protein kinase C substrate 80K-H	Homo sapiens	46-53
19625484-9	2009	Our results clearly demonstrate the capacity of the GIIbeta-MRH to bind high-mannose-type glycans and its importance in efficient glucose trimming of N-glycans.	Polysaccharides	90-97	protein kinase C substrate 80K-H	Homo sapiens	52-59
19640982-4	2009	GPG-NH(2) treatment was found to affect Env by significantly decreasing its steady-state levels, its processing into gp120/gp41, and its mass by inducing glycan removal in a manner dependent on its native signal sequence and the proteasome.	Polysaccharides	154-160	endogenous retrovirus group K member 20	Homo sapiens	40-43
19756298-3	2009	Available evidence indicates that GBP binding sites may accommodate glycan determinants made up of 2 to 6 linear monosaccharides, together with their potential side chains containing other sugars and modifications, such as sulfation, phosphorylation, and acetylation.	Polysaccharides	68-74	transmembrane protein 132A	Homo sapiens	34-37
19756298-5	2009	Based on our current knowledge of the composition of the glycome and the size of GBP binding sites, glycoproteins and glycolipids may contain approximately 3000 glycan determinants with an additional approximately 4000 theoretical pentasaccharide sequences in glycosaminoglycans.	Polysaccharides	161-167	transmembrane protein 132A	Homo sapiens	81-84
21048648-8	2009	RESULTS: Compared with the I/R group, YLS polysaccharide reduced the neurological score, the brain water content, the infract volume, MDA and NO contents, the NOS activity, and the expression of Bax, and increased SOD activity, and the expression of Bcl-2 in the brain tissue, and neuronal edema was reduced.	Polysaccharides	42-56	BCL2, apoptosis regulator	Rattus norvegicus	250-255
19805264-0	2009	Chemoenzymatic synthesis of GDP-L-fucose and the Lewis X glycan derivatives.	Polysaccharides	57-63	fucosyltransferase 4	Homo sapiens	49-56
19784394-1	2009	PURPOSE: To assess the effects of polysaccharide extract from Spirulina platensis (PSP) on corneal neovascularization (CNV) in vivo and in vitro.	Polysaccharides	34-48	regenerating family member 1 alpha	Homo sapiens	83-86
19805264-1	2009	Lewis X (Le(x))-containing glycans play important roles in numerous cellular processes.	Polysaccharides	27-34	fucosyltransferase 4	Homo sapiens	0-7
19559777-5	2009	RESULTS: AEP and four purified polysaccharides could not only significantly inhibit the growth of mouse transplantable tumor, but also remarkably promote splenocytes proliferation, NK cell and CTL activity, IL-2 and IFN-gamma production from splenocytes, and serum antigen-specific antibody levels in tumor-bearing mice.	Polysaccharides	31-46	interleukin 2	Mus musculus	207-211
19710450-2	2009	The CD21/35 receptor is thought to promote protective humoral immunity to encapsulated bacteria by enabling complement-decorated capsular polysaccharides to coligate the CD21/35-CD19 signaling complex with the B cell Ag receptor (BCR), thereby enhancing Ag-specific B cell activation.	Polysaccharides	138-153	complement receptor 2	Mus musculus	4-8
19710450-2	2009	The CD21/35 receptor is thought to promote protective humoral immunity to encapsulated bacteria by enabling complement-decorated capsular polysaccharides to coligate the CD21/35-CD19 signaling complex with the B cell Ag receptor (BCR), thereby enhancing Ag-specific B cell activation.	Polysaccharides	138-153	complement receptor 2	Mus musculus	170-174
19710450-2	2009	The CD21/35 receptor is thought to promote protective humoral immunity to encapsulated bacteria by enabling complement-decorated capsular polysaccharides to coligate the CD21/35-CD19 signaling complex with the B cell Ag receptor (BCR), thereby enhancing Ag-specific B cell activation.	Polysaccharides	138-153	CD19 antigen	Mus musculus	178-182
19710450-3	2009	However, Ab responses to S. pneumoniae type 3 capsular polysaccharide (PPS-3) and other strong TI-2 Ags were significantly impaired in CD21/35(-/-) but not C3(-/-) or C4(-/-) mice.	Polysaccharides	55-69	complement receptor 2	Mus musculus	135-139
19559777-5	2009	RESULTS: AEP and four purified polysaccharides could not only significantly inhibit the growth of mouse transplantable tumor, but also remarkably promote splenocytes proliferation, NK cell and CTL activity, IL-2 and IFN-gamma production from splenocytes, and serum antigen-specific antibody levels in tumor-bearing mice.	Polysaccharides	31-46	interferon gamma	Mus musculus	216-225
19546196-0	2009	Oligoclonal CD4+ T cells promote host memory immune responses to Zwitterionic polysaccharide of Streptococcus pneumoniae.	Polysaccharides	78-92	CD4 antigen	Mus musculus	12-15
19440230-3	2009	As platelet-derived growth factor-bb (PDGF-BB) and fibroblast growth factor-2 (FGF-2) are known to induce chemotaxis, proliferation, differentiation, and matrix synthesis, we investigated a non-viral means for gene delivery of these factors using the cationic polysaccharide chitosan.	Polysaccharides	260-274	fibroblast growth factor 2	Mus musculus	79-84
19555665-0	2009	NKG2D and CD94 bind to heparin and sulfate-containing polysaccharides.	Polysaccharides	54-69	killer cell lectin like receptor K1	Homo sapiens	0-5
19555665-0	2009	NKG2D and CD94 bind to heparin and sulfate-containing polysaccharides.	Polysaccharides	54-69	killer cell lectin like receptor D1	Homo sapiens	10-14
19555665-1	2009	Killer lectin-like receptors NKG2D and CD94 on natural killer cells trigger cytotoxicity through binding of glycans on target cells including sialyl Lewis X antigen.	Polysaccharides	108-115	killer cell lectin like receptor K1	Homo sapiens	29-34
19555665-1	2009	Killer lectin-like receptors NKG2D and CD94 on natural killer cells trigger cytotoxicity through binding of glycans on target cells including sialyl Lewis X antigen.	Polysaccharides	108-115	killer cell lectin like receptor D1	Homo sapiens	39-43
19555665-3	2009	Here we further investigated polysaccharide binding by these receptors, using glutathione-S-transferase-fused extracellular domains of NKG2D AA 73-216 (rNKG2Dlec) and CD94 AA 68-179 (rCD94lec).	Polysaccharides	29-43	killer cell lectin like receptor K1	Homo sapiens	135-140
19555665-7	2009	The present manuscript provides the first evidence that NKG2D and CD94 bind to heparin and sulfate-containing polysaccharides.	Polysaccharides	110-125	killer cell lectin like receptor K1	Homo sapiens	56-61
19555665-7	2009	The present manuscript provides the first evidence that NKG2D and CD94 bind to heparin and sulfate-containing polysaccharides.	Polysaccharides	110-125	killer cell lectin like receptor D1	Homo sapiens	66-70
19492981-1	2009	Chondroitin sulfate (CS), a polysaccharide moiety of proteoglycans, is one of the major components of the extracellular matrix in the central nervous system and is involved in various cellular events in the formation and maintenance of the neural network.	Polysaccharides	28-42	citrate synthase	Homo sapiens	21-23
19541770-7	2009	In addition, gal-1 binding to Davanat also modifies the supermolecular structure of the galactomannan and appears to reduce its hydrodynamic radius and disrupt inter-glycan interactions thereby reducing glycan-mediated solution viscosity.	Polysaccharides	166-172	galectin 1	Homo sapiens	13-18
19541770-7	2009	In addition, gal-1 binding to Davanat also modifies the supermolecular structure of the galactomannan and appears to reduce its hydrodynamic radius and disrupt inter-glycan interactions thereby reducing glycan-mediated solution viscosity.	Polysaccharides	203-209	galectin 1	Homo sapiens	13-18
20636023-3	2009	Special interest is directed toward antibodies binding to the glycan array on gp120 since they have the potential of broader reactivity and cross-clade neutralizing capacity.	Polysaccharides	62-68	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	78-83
19546196-2	2009	Presentation of these polysaccharides to CD4(+) T cells depends on major histocompatibility complex class II- and DM-dependent retrograde transport from lysosomes to the cell surface.	Polysaccharides	22-37	CD4 antigen	Mus musculus	41-44
19546196-4	2009	Using the zwitterionic capsular polysaccharide Sp1 of Streptococcus pneumoniae, a transient member of the bacterial flora, in an experimental mouse model of cellular immunity, we demonstrated the accumulation of TH1- and TH17-polarized CD4(+) CD44(high) CD62(low) CD25(-) memory T cells.	Polysaccharides	32-46	negative elongation factor complex member C/D, Th1l	Mus musculus	212-215
19546196-4	2009	Using the zwitterionic capsular polysaccharide Sp1 of Streptococcus pneumoniae, a transient member of the bacterial flora, in an experimental mouse model of cellular immunity, we demonstrated the accumulation of TH1- and TH17-polarized CD4(+) CD44(high) CD62(low) CD25(-) memory T cells.	Polysaccharides	32-46	CD4 antigen	Mus musculus	236-239
19546196-6	2009	CD4(+) T cells stimulated with polysaccharide in vitro and in vivo showed a nonrestricted pattern for the T-cell receptor (TCR) beta-chain variable region, as demonstrated by semiquantitative reverse transcription-PCR and flow cytometry.	Polysaccharides	31-45	CD4 antigen	Mus musculus	0-3
19546196-7	2009	Clonotype mapping of in vivo and in vitro polysaccharide-activated CD4(+) T cells revealed clonotypic TCR transcripts.	Polysaccharides	42-56	CD4 antigen	Mus musculus	67-70
19546196-8	2009	Taken together, the data show the induction of clonal expansion of CD4(+) T cells by polysaccharides of commensal bacteria.	Polysaccharides	85-100	CD4 antigen	Mus musculus	67-70
19467319-3	2009	Analysis of the maturation process of conjugate polyclonal antibody showed that conjugation with the protein carrier converted the polysaccharide from a weak T cell-independent (TI) antigen to a T cell-dependent (TD) antigen, although antibodies affinity to polysaccharide was not as strong as it to PspA in conjugate.	Polysaccharides	131-145	surfactant associated protein A1	Mus musculus	300-304
19470522-2	2009	By using glycan microarray analysis and other assays, we found that human C21orf63 interacts with heparin and to a lesser extent with heparan sulphate.	Polysaccharides	9-15	eva-1 homolog C	Homo sapiens	74-82
19467319-6	2009	Our study"s results showed that immunization of the 5-valent PspA-capsular polysaccharides conjugate vaccine could afford strong protection to mice against the invasion of 1, 5, 6B, 19F, 23F serotypes S. pneumoniae.	Polysaccharides	75-90	surfactant associated protein A1	Mus musculus	61-65
19668862-7	2009	Reporter systems with segments of the IL-8 promoter showed a specific activation in response to hm-sulfated polysaccharides with lower pathophysiological potential in vivo and provided a better classification of CGN-variants than cytotoxicity assays in vitro.	Polysaccharides	108-123	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
19577628-8	2009	The results strengthen the concept that IL-17A-mediated T cell immunity is inducible by zwitterionic polysaccharides with sufficient chain length to provide coiled secondary structure.	Polysaccharides	101-116	interleukin 17A	Mus musculus	40-46
19605557-7	2009	The interaction of the mannose 6-phosphate receptor homologous domain present in GIIbeta and mannoses in the B and/or C arms of the glycans mediates glycan hydrolysis enhancement.	Polysaccharides	132-139	protein kinase C substrate 80K-H	Homo sapiens	81-88
19605557-7	2009	The interaction of the mannose 6-phosphate receptor homologous domain present in GIIbeta and mannoses in the B and/or C arms of the glycans mediates glycan hydrolysis enhancement.	Polysaccharides	132-138	protein kinase C substrate 80K-H	Homo sapiens	81-88
19668862-8	2009	IL-8 reporter systems can be used for discerning between the effects of sulfated polysaccharides in vivo.	Polysaccharides	81-96	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
19560125-0	2009	Study on systematizing the synthesis of the a-series ganglioside glycans GT1a, GD1a, and GM1 using the newly developed N-Troc-protected GM3 and GalN intermediates.	Polysaccharides	65-72	galanin and GMAP prepropeptide	Homo sapiens	144-148
19825661-7	2009	Several genes from the cellulose synthase-like (Csl) family have been found to be involved in the synthesis of various hemicellulosic glycans.	Polysaccharides	134-141	chorionic somatomammotropin hormone like 1	Homo sapiens	23-46
19825661-7	2009	Several genes from the cellulose synthase-like (Csl) family have been found to be involved in the synthesis of various hemicellulosic glycans.	Polysaccharides	134-141	chorionic somatomammotropin hormone like 1	Homo sapiens	48-51
19524131-0	2009	Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes.	Polysaccharides	11-26	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	55-60
20337379-4	2009	Additional studies indicate that these species (1-10% total glycans) are sample preparation artifacts caused by base-catalyzed epimerization of N-acetylglucosamine (GlcNAc) at the reducing terminus by following the use of commercially available PNGase F and the supplied incubation buffer (pH 7.5).	Polysaccharides	60-67	N-glycanase 1	Homo sapiens	245-251
19524131-0	2009	Astragalus polysaccharides decreased the expression of PTP1B through relieving ER stress induced activation of ATF6 in a rat model of type 2 diabetes.	Polysaccharides	11-26	activating transcription factor 6	Rattus norvegicus	111-115
19458105-2	2009	Antibody engagement of Siglec-8 on eosinophils causes their apoptosis, suggesting that engagement of Siglec-8 with its natural glycan ligands in vivo may control allergic inflammation.	Polysaccharides	127-133	sialic acid binding Ig like lectin 8	Homo sapiens	23-31
19540883-7	2009	Although allergenic alpha1,3-fucose residues have been found in T. ni cells, only alpha1,6-fucose residues were attached to the beta3GnT2 glycan in silkworm larvae.	Polysaccharides	138-144	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	128-137
19597144-5	2009	EBS2 encodes the Arabidopsis CRT3 that interacts with ER-localized bri1-9 in a glycan-dependent manner.	Polysaccharides	79-85	calreticulin 3	Arabidopsis thaliana	0-4
19597144-5	2009	EBS2 encodes the Arabidopsis CRT3 that interacts with ER-localized bri1-9 in a glycan-dependent manner.	Polysaccharides	79-85	calreticulin 3	Arabidopsis thaliana	29-33
19597144-5	2009	EBS2 encodes the Arabidopsis CRT3 that interacts with ER-localized bri1-9 in a glycan-dependent manner.	Polysaccharides	79-85	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	67-73
19451241-8	2009	The critical epitope alpha-d-Glcp(1--&gt;3)alpha-l-Rhap is found in the capsular PSs of serotypes 6A, 6B, 6C, and 19A but not in the 19F PS.	Polysaccharides	81-84	SLAM family member 7	Homo sapiens	114-117
19458105-2	2009	Antibody engagement of Siglec-8 on eosinophils causes their apoptosis, suggesting that engagement of Siglec-8 with its natural glycan ligands in vivo may control allergic inflammation.	Polysaccharides	127-133	sialic acid binding Ig like lectin 8	Homo sapiens	101-109
19458105-3	2009	We report that a soluble synthetic polymer displaying 6"-sulfo-sLe(x) glycan selectively binds to human eosinophils and human embryonic kidney 293 cells expressing Siglec-8.	Polysaccharides	70-76	sialic acid binding Ig like lectin 8	Homo sapiens	164-172
19458105-6	2009	Interleukin-5-primed eosinophils underwent apoptosis when incubated with either anti-Siglec-8 monoclonal antibody or polymeric 6"-sulfo-sLe(x), although the glycan polymer was less effective.	Polysaccharides	157-163	interleukin 5	Homo sapiens	0-13
19442736-2	2009	When Galgt2, the glycosyltransferase that creates the synaptic beta1,4GalNAc portion of this glycan, is overexpressed in extrasynaptic regions of the myofiber membrane, alpha dystroglycan becomes glycosylated with the CT carbohydrate and this coincides with the ectopic expression of synaptic dystroglycan-binding proteins, including laminin alpha4, laminin alpha5, and utrophin.	Polysaccharides	93-99	beta-1,4-N-acetyl-galactosaminyl transferase 2	Mus musculus	5-11
19442736-2	2009	When Galgt2, the glycosyltransferase that creates the synaptic beta1,4GalNAc portion of this glycan, is overexpressed in extrasynaptic regions of the myofiber membrane, alpha dystroglycan becomes glycosylated with the CT carbohydrate and this coincides with the ectopic expression of synaptic dystroglycan-binding proteins, including laminin alpha4, laminin alpha5, and utrophin.	Polysaccharides	93-99	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	17-36
19764413-5	2009	Recently, dectin-1, a C-type lectin receptor, has garnered attention as a sole receptor of beta-1,3-glucan, a major polysaccharide component of the fungal cell wall.	Polysaccharides	116-130	C-type lectin domain family 7, member a	Mus musculus	10-18
19520434-10	2009	As CD5 has both N- and O-linked glycosylation, we hypothesised that differential binding of KEN-5 to T cells and B-cells may be explained by different glycan structures on the CD5 present on T compared to B cells.	Polysaccharides	151-157	CD5 molecule	Homo sapiens	176-179
19520434-15	2009	Our findings suggest that development, selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules expressed on T cells compared to B cells.	Polysaccharides	181-187	T-cell surface glycoprotein CD5	Oryctolagus cuniculus	215-218
19520434-15	2009	Our findings suggest that development, selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules expressed on T cells compared to B cells.	Polysaccharides	181-187	T-cell surface glycoprotein CD5	Oryctolagus cuniculus	222-225
19608758-1	2009	In this issue of Blood, Hernandez Mir and colleagues provide the most detailed analysis to date of the glycans on an HEV-expressed ligand (CD34) isolated from a human lymphoid organ, (tonsils), adding to our understanding of how L-selectin mediates lymphocyte homing.	Polysaccharides	103-110	selectin L	Homo sapiens	229-239
20360893-1	2009	Maitake D-fraction or PDF is the bioactive extract of maitake mushroom (Grifola frondosa) and its active constituent is the protein-bound polysaccharide (proteoglucan), or more specifically known as beta-glucan.	Polysaccharides	138-152	peptide deformylase, mitochondrial	Homo sapiens	22-25
19497853-1	2009	Antithrombin, a major regulator of coagulation and angiogenesis, is known to interact with several natural sulfated polysaccharides.	Polysaccharides	116-131	serpin family C member 1	Homo sapiens	0-12
19587235-5	2009	The decrease of laminin-binding glycans and consequent increased cell migration were associated with the decreased expression of beta3-N-acetylglucosaminyltransferase-1 (beta3GnT1).	Polysaccharides	32-39	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	129-168
19587235-5	2009	The decrease of laminin-binding glycans and consequent increased cell migration were associated with the decreased expression of beta3-N-acetylglucosaminyltransferase-1 (beta3GnT1).	Polysaccharides	32-39	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	170-179
19587235-6	2009	Forced expression of beta3GnT1 in aggressive cancer cells restored the laminin-binding glycans and decreased tumor formation.	Polysaccharides	87-94	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	21-30
19587235-7	2009	beta3GnT1 was found to be required for laminin-binding glycan synthesis through formation of a complex with LARGE, thus regulating the function of LARGE.	Polysaccharides	55-61	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	0-9
19587235-8	2009	Interaction of the laminin-binding glycans with laminin and other adhesive molecules in BM attenuates tumor cell migratory potential by antagonizing ERK/AKT phosphorylation induced by the components in the ECM.	Polysaccharides	35-42	mitogen-activated protein kinase 1	Homo sapiens	149-152
19587235-8	2009	Interaction of the laminin-binding glycans with laminin and other adhesive molecules in BM attenuates tumor cell migratory potential by antagonizing ERK/AKT phosphorylation induced by the components in the ECM.	Polysaccharides	35-42	AKT serine/threonine kinase 1	Homo sapiens	153-156
19608758-1	2009	In this issue of Blood, Hernandez Mir and colleagues provide the most detailed analysis to date of the glycans on an HEV-expressed ligand (CD34) isolated from a human lymphoid organ, (tonsils), adding to our understanding of how L-selectin mediates lymphocyte homing.	Polysaccharides	103-110	membrane associated ring-CH-type finger 8	Homo sapiens	34-37
19608758-1	2009	In this issue of Blood, Hernandez Mir and colleagues provide the most detailed analysis to date of the glycans on an HEV-expressed ligand (CD34) isolated from a human lymphoid organ, (tonsils), adding to our understanding of how L-selectin mediates lymphocyte homing.	Polysaccharides	103-110	CD34 molecule	Homo sapiens	139-143
20606780-1	2009	A study was undertaken to evaluate the hypoglycemic activity of polysaccharide extracted from Lycium barbarum (LBP).	Polysaccharides	64-78	lipopolysaccharide binding protein	Mus musculus	111-114
19912977-1	2009	BACKGROUND: Beta-1-3 Glucan is a polysaccharide extracted from Saccharomyces cerevisiae with a possible immunomodulating action that may have a favourable action on asthma symptoms and other allergic diseases.	Polysaccharides	33-47	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	12-20
19594491-4	2009	We investigated monocyte production of the pro-inflammatory cytokine tumour necrosis factor-alpha (TNF-alpha) and the regulatory cytokine interleukin-10 (IL-10) after combined exposure to the fungal cell wall polysaccharide mannan and to the beta-glucan laminarin, the mycotoxin citrinin and bacterial lipopolysaccharide (LPS).	Polysaccharides	209-223	interleukin 10	Homo sapiens	138-152
19371327-4	2009	Given the complex nature of cell-surface and extracellular matrix glycan structures, this therapeutic site has been neglected for a long time, the only exception being the antithrombin III-glycan interaction which has been successfully targeted by unfractionated and low-molecular weight heparins for many decades.	Polysaccharides	66-72	serpin family C member 1	Homo sapiens	172-188
19371327-4	2009	Given the complex nature of cell-surface and extracellular matrix glycan structures, this therapeutic site has been neglected for a long time, the only exception being the antithrombin III-glycan interaction which has been successfully targeted by unfractionated and low-molecular weight heparins for many decades.	Polysaccharides	189-195	serpin family C member 1	Homo sapiens	172-188
19395868-1	2009	In view of the need for a cost effective Haemophilus influenzae type b (Hib) conjugate vaccine, a lyophilized vaccine as capsular polysaccharide (PRP) conjugated to tetanus toxoid (Sii HibPRO) was indigenously developed by Serum Institute of India Ltd., Pune (SIIL).	Polysaccharides	130-144	prion protein	Homo sapiens	146-149
19803057-1	2009	REASONS FOR PERFORMING STUDY: A glycogen synthase (GYS1) mutation has been described in horses with histopathological evidence of polysaccharide storage myopathy (PSSM) in the USA.	Polysaccharides	130-144	glycogen synthase 1	Equus caballus	51-55
19453144-3	2009	We previously demonstrated that liquid chromatography-multiple-stage mass spectrometry (LC-MSn) allowed for differentiation of oligosaccharides attached to Lewis-motifs, such as Lewisx(Lex, Galbeta1-4(Fucalpha1-3)GlcNAc) from other glycans.	Polysaccharides	232-239	moesin	Mus musculus	91-94
19594629-4	2009	This review explains the "intelligent design" of requisite reagents to convert native CD44 into the sialofucosylated glycoform known as hematopoietic cell E-/L-selectin ligand (HCELL), the most potent E-selectin counter-receptor expressed on human cells, and will describe how ex vivo glycan engineering of HCELL expression may open the "avenues" for the efficient vascular delivery of cells for a variety of cell therapies.	Polysaccharides	285-291	CD44 molecule (Indian blood group)	Homo sapiens	86-90
19594629-4	2009	This review explains the "intelligent design" of requisite reagents to convert native CD44 into the sialofucosylated glycoform known as hematopoietic cell E-/L-selectin ligand (HCELL), the most potent E-selectin counter-receptor expressed on human cells, and will describe how ex vivo glycan engineering of HCELL expression may open the "avenues" for the efficient vascular delivery of cells for a variety of cell therapies.	Polysaccharides	285-291	CD44 molecule (Indian blood group)	Homo sapiens	136-175
19594629-4	2009	This review explains the "intelligent design" of requisite reagents to convert native CD44 into the sialofucosylated glycoform known as hematopoietic cell E-/L-selectin ligand (HCELL), the most potent E-selectin counter-receptor expressed on human cells, and will describe how ex vivo glycan engineering of HCELL expression may open the "avenues" for the efficient vascular delivery of cells for a variety of cell therapies.	Polysaccharides	285-291	CD44 molecule (Indian blood group)	Homo sapiens	177-182
19594632-4	2009	Galectin-3 exerts extracellular functions because of its lectin activity and recognition of cell surface and extracellular matrix glycans.	Polysaccharides	130-137	galectin 3	Homo sapiens	0-10
19594634-3	2009	Galectin-1, an endogenous glycan-binding protein widely expressed at sites of inflammation and tumor growth, controls a diversity of immune cell processes, acting either extracellularly through specific binding to cell surface glycan structures or intracellularly through modulation of pathways that remain largely unexplored.	Polysaccharides	26-32	galectin 1	Homo sapiens	0-10
19594638-3	2009	Notch receptors and ligands are post-translationally modified by the addition of glycans to extracellular domain epidermal growth factor-like (EGF) repeats.	Polysaccharides	81-88	notch receptor 1	Homo sapiens	0-5
19594638-5	2009	These glycans are initiated by protein O-fucosyltransferase 1 (Pofut1), and elongated by the transfer of N-acetylglucosamine (GlcNAc) to the fucose by beta1,3GlcNAc-transferases termed lunatic, manic, or radical fringe.	Polysaccharides	6-13	protein O-fucosyltransferase 1	Homo sapiens	31-61
19594638-5	2009	These glycans are initiated by protein O-fucosyltransferase 1 (Pofut1), and elongated by the transfer of N-acetylglucosamine (GlcNAc) to the fucose by beta1,3GlcNAc-transferases termed lunatic, manic, or radical fringe.	Polysaccharides	6-13	protein O-fucosyltransferase 1	Homo sapiens	63-69
19594638-9	2009	Removal of O-fucose affects Notch signaling in myelopoiesis and lymphopoiesis, and the O-fucose glycan in the Notch1 ligand-binding domain is required for optimal T-cell development.	Polysaccharides	96-102	notch receptor 1	Homo sapiens	110-116
23961039-14	2009	The presence of sulfated polysaccharide material in the fractions UF2, DF2 and SF2 were found as cell wall storage of marine algae, confirmed by (13)C NMR spectroscopy.	Polysaccharides	25-39	serine and arginine rich splicing factor 1	Homo sapiens	79-82
19476346-5	2009	Solid phase array analysis identified two HCR/F binding glycans: ganglioside GD1a and oligosaccharides containing an N-acetyllactosamine core.	Polysaccharides	56-63	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	42-45
19432560-0	2009	The carbohydrate-binding domain on galectin-1 is more extensive for a complex glycan than for simple saccharides: implications for galectin-glycan interactions at the cell surface.	Polysaccharides	78-84	galectin 1	Homo sapiens	35-45
19432560-0	2009	The carbohydrate-binding domain on galectin-1 is more extensive for a complex glycan than for simple saccharides: implications for galectin-glycan interactions at the cell surface.	Polysaccharides	140-146	galectin 1	Homo sapiens	35-45
19432560-2	2009	Although most structural studies with gal-1 have investigated its binding to simple carbohydrates, in particular lactose and N-acetyl-lactosamine, this view is limited, because gal-1 functions at the cell surface by interacting with more complex glycans that are heterogeneous in size and composition.	Polysaccharides	246-253	galectin 1	Homo sapiens	177-182
19432560-3	2009	In the present study we used NMR spectroscopy to investigate the interaction of human gal-1 with a large (120 kDa) complex glycan, GRG (galactorhamnogalacturonate glycan), that contains non-randomly distributed mostly terminal beta(1--&gt;4)-linked galactose side chains.	Polysaccharides	123-129	galectin 1	Homo sapiens	86-91
19432560-8	2009	In addition, gal-1 binding to GRG disrupts inter-glycan interactions and decreases glycan-mediated solution viscosity, a glycan decongestion effect that may help explain why gal-1 promotes membrane fluidity and lateral diffusion of glycoconjugates within cell membranes.	Polysaccharides	49-55	galectin 1	Homo sapiens	13-18
19432560-8	2009	In addition, gal-1 binding to GRG disrupts inter-glycan interactions and decreases glycan-mediated solution viscosity, a glycan decongestion effect that may help explain why gal-1 promotes membrane fluidity and lateral diffusion of glycoconjugates within cell membranes.	Polysaccharides	49-55	galectin 1	Homo sapiens	174-179
19432560-8	2009	In addition, gal-1 binding to GRG disrupts inter-glycan interactions and decreases glycan-mediated solution viscosity, a glycan decongestion effect that may help explain why gal-1 promotes membrane fluidity and lateral diffusion of glycoconjugates within cell membranes.	Polysaccharides	83-89	galectin 1	Homo sapiens	13-18
19432560-8	2009	In addition, gal-1 binding to GRG disrupts inter-glycan interactions and decreases glycan-mediated solution viscosity, a glycan decongestion effect that may help explain why gal-1 promotes membrane fluidity and lateral diffusion of glycoconjugates within cell membranes.	Polysaccharides	83-89	galectin 1	Homo sapiens	174-179
19432560-8	2009	In addition, gal-1 binding to GRG disrupts inter-glycan interactions and decreases glycan-mediated solution viscosity, a glycan decongestion effect that may help explain why gal-1 promotes membrane fluidity and lateral diffusion of glycoconjugates within cell membranes.	Polysaccharides	83-89	galectin 1	Homo sapiens	13-18
19432560-8	2009	In addition, gal-1 binding to GRG disrupts inter-glycan interactions and decreases glycan-mediated solution viscosity, a glycan decongestion effect that may help explain why gal-1 promotes membrane fluidity and lateral diffusion of glycoconjugates within cell membranes.	Polysaccharides	83-89	galectin 1	Homo sapiens	174-179
19400583-0	2009	Cations modulate polysaccharide structure to determine FGF-FGFR signaling: a comparison of signaling and inhibitory polysaccharide interactions with FGF-1 in solution.	Polysaccharides	17-31	fibroblast growth factor 1	Homo sapiens	55-58
19389450-0	2009	Novel polysaccharide adjuvant from the roots of Actinidia eriantha with dual Th1 and Th2 potentiating activity.	Polysaccharides	6-20	negative elongation factor complex member C/D, Th1l	Mus musculus	77-80
19389450-0	2009	Novel polysaccharide adjuvant from the roots of Actinidia eriantha with dual Th1 and Th2 potentiating activity.	Polysaccharides	6-20	heart and neural crest derivatives expressed 2	Mus musculus	85-88
19470764-8	2009	CHST10 is a sulfotransferase that forms HNK-1 glycan on neural cell adhesion proteins and glycolipids, and HNK-1 is thought to modulate cell adhesion and possibly metastasis.	Polysaccharides	46-52	carbohydrate sulfotransferase 10	Mus musculus	0-6
19470764-8	2009	CHST10 is a sulfotransferase that forms HNK-1 glycan on neural cell adhesion proteins and glycolipids, and HNK-1 is thought to modulate cell adhesion and possibly metastasis.	Polysaccharides	46-52	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	40-45
19410242-3	2009	The chemical structures of the polysaccharides were highly branched alpha-(1--&gt;4)-D-glucan heteropolysaccharides and the values of degree of branch (DB) were in the range of 35-45% for RPS1 to RPS5.	Polysaccharides	31-46	ribosomal protein S5	Homo sapiens	196-200
19410242-4	2009	All of the polysaccharides were water soluble, and their solubility decreased from RPS1 to RPS5.	Polysaccharides	11-26	ribosomal protein S5	Homo sapiens	91-95
19524542-4	2009	We show that EDEM1 specifically binds nonnative proteins in a glycan-independent manner.	Polysaccharides	62-68	ER degradation enhancing alpha-mannosidase like protein 1	Homo sapiens	13-18
19400583-0	2009	Cations modulate polysaccharide structure to determine FGF-FGFR signaling: a comparison of signaling and inhibitory polysaccharide interactions with FGF-1 in solution.	Polysaccharides	116-130	fibroblast growth factor 1	Homo sapiens	149-154
19400583-6	2009	Secondary structures in solution complexes of polysaccharides with FGF-1 (which either supported signaling through FGFR1c or were inhibitory) were determined by SRCD.	Polysaccharides	46-61	fibroblast growth factor 1	Homo sapiens	67-72
19400583-7	2009	This allowed direct comparison of the two FGF-1-polysaccharide complexes in solution, containing identical molecular components and differing only in their cation content.	Polysaccharides	48-62	fibroblast growth factor 1	Homo sapiens	42-47
19336400-1	2009	The polysialyltransferases ST8Sia II and ST8Sia IV polysialylate the glycans of a small subset of mammalian proteins.	Polysaccharides	69-76	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	27-36
19336400-1	2009	The polysialyltransferases ST8Sia II and ST8Sia IV polysialylate the glycans of a small subset of mammalian proteins.	Polysaccharides	69-76	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	41-50
19491856-1	2009	OBJECTIVES: We sought to evaluate whether two novel immunoglobulin A (IgA) cell wall polysaccharide antibodies, anti-laminarin (anti-L) and anti-chitin (anti-C), aid in the diagnosis and phenotype differentiation of Crohn"s disease (CD) and ulcerative colitis (UC).	Polysaccharides	85-99	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	70-73
19470241-6	2009	These data indicate that polysaccharides from A. pectinifera increase phase II detoxification enzyme activity and inhibit ODC and COX-2 activities in HT-29 human colon adenocarcinoma cells.	Polysaccharides	25-40	ornithine decarboxylase 1	Homo sapiens	122-125
19287024-0	2009	Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2.	Polysaccharides	24-39	C-type lectin domain containing 7A	Homo sapiens	67-75
19287024-0	2009	Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2.	Polysaccharides	24-39	C-type lectin domain containing 6A	Homo sapiens	80-88
19478457-1	2009	IgA nephropathy (IgAN) is characterized by circulating immune complexes composed of galactose-deficient IgA1 and a glycan-specific IgG antibody.	Polysaccharides	115-121	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	0-3
19478457-1	2009	IgA nephropathy (IgAN) is characterized by circulating immune complexes composed of galactose-deficient IgA1 and a glycan-specific IgG antibody.	Polysaccharides	115-121	IGAN1	Homo sapiens	17-21
19478457-6	2009	Finally, we developed a dot-blot assay for the glycan-specific IgG antibody that differentiated patients with IgAN from healthy and disease controls with 88% specificity and 95% sensitivity and found that elevated levels of this antibody in the sera of patients with IgAN correlated with proteinuria.	Polysaccharides	47-53	IGAN1	Homo sapiens	110-114
19478457-6	2009	Finally, we developed a dot-blot assay for the glycan-specific IgG antibody that differentiated patients with IgAN from healthy and disease controls with 88% specificity and 95% sensitivity and found that elevated levels of this antibody in the sera of patients with IgAN correlated with proteinuria.	Polysaccharides	47-53	IGAN1	Homo sapiens	267-271
19478457-7	2009	Collectively, these findings indicate that glycan-specific antibodies are associated with the development of IgAN and may represent a disease-specific marker and potential therapeutic target.	Polysaccharides	43-49	IGAN1	Homo sapiens	109-113
19431040-3	2009	We also found that PS increased the ratio of Bax/Bcl-2 and activated caspase-9 and caspase-3 but not caspase-8.	Polysaccharides	19-21	BCL2-associated X protein	Mus musculus	45-48
19431040-3	2009	We also found that PS increased the ratio of Bax/Bcl-2 and activated caspase-9 and caspase-3 but not caspase-8.	Polysaccharides	19-21	B cell leukemia/lymphoma 2	Mus musculus	49-54
19431040-3	2009	We also found that PS increased the ratio of Bax/Bcl-2 and activated caspase-9 and caspase-3 but not caspase-8.	Polysaccharides	19-21	caspase 9	Mus musculus	69-78
19431040-3	2009	We also found that PS increased the ratio of Bax/Bcl-2 and activated caspase-9 and caspase-3 but not caspase-8.	Polysaccharides	19-21	caspase 3	Mus musculus	83-92
19238561-5	2009	Furthermore, ZmMYB42 affects the cell wall structure and degradability, and its polysaccharide composition.	Polysaccharides	80-94	transcription factor MYB42	Zea mays	13-20
19551730-0	2009	Immunological adjuvant effect of a water-soluble polysaccharide, CPP, from the roots of Codonopsis pilosula on the immune responses to ovalbumin in mice.	Polysaccharides	49-63	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	135-144
19499518-5	2009	A murine monoclonal antibody (206, F-5) against the serotype 9V capsular polysaccharide identified three peptide mimotopes from the dodecameric peptide library and one from a random pentadecameric peptide library.	Polysaccharides	73-87	coagulation factor V	Mus musculus	35-38
19536613-2	2009	Using sea urchin embryos, we previously demonstrated that the bulk of ARS is located on the cell surface of the epithelium, colocalizing with sulfated polysaccharides, and that it does not exhibit enzymatic activity.	Polysaccharides	151-166	RIEG2	Homo sapiens	70-73
19470241-6	2009	These data indicate that polysaccharides from A. pectinifera increase phase II detoxification enzyme activity and inhibit ODC and COX-2 activities in HT-29 human colon adenocarcinoma cells.	Polysaccharides	25-40	COX2	Patiria pectinifera	130-135
19332543-3	2009	Purified SlSBT3 was identified as a 79-kDa glycoprotein with both complex and paucimannosidic type glycan chains at Asn(177), Asn(203), Asn(376), Asn(697), and Asn(745).	Polysaccharides	99-105	subtilisin-like protease	Solanum lycopersicum	9-15
19458237-0	2009	Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth.	Polysaccharides	29-36	contactin 2	Homo sapiens	57-62
19458237-0	2009	Lewis(x) and alpha2,3-sialyl glycans and their receptors TAG-1, Contactin, and L1 mediate CD24-dependent neurite outgrowth.	Polysaccharides	29-36	CD24 molecule	Homo sapiens	90-94
19458237-6	2009	Their cis interactions with neighboring adhesion molecules, e.g., Caspr1 and Caspr2, and with their triggered signal transduction pathways elicit cell type-specific promotion or inhibition of neurite outgrowth induced by glial CD24 in a glycan-dependent trans interaction.	Polysaccharides	237-243	contactin associated protein 1	Homo sapiens	66-72
19458237-6	2009	Their cis interactions with neighboring adhesion molecules, e.g., Caspr1 and Caspr2, and with their triggered signal transduction pathways elicit cell type-specific promotion or inhibition of neurite outgrowth induced by glial CD24 in a glycan-dependent trans interaction.	Polysaccharides	237-243	contactin associated protein 2	Homo sapiens	77-83
19458237-6	2009	Their cis interactions with neighboring adhesion molecules, e.g., Caspr1 and Caspr2, and with their triggered signal transduction pathways elicit cell type-specific promotion or inhibition of neurite outgrowth induced by glial CD24 in a glycan-dependent trans interaction.	Polysaccharides	237-243	CD24 molecule	Homo sapiens	227-231
19326097-3	2009	Bioinformatic analysis revealed that VVA0331 consist of nineteen 87-amino acid repeats, two Arg-Gly-Asp motifs, four cysteine residues, an outer membrane protein domain, a polysaccharide-binding site and several motifs related to cell adhesions.	Polysaccharides	172-186	BJE04_RS17365	Vibrio vulnificus YJ016	37-44
19368346-9	2009	This work revealed the presence of three types of mucin with distinct glycan profiles in human pancreatic juice.	Polysaccharides	70-76	LOC100508689	Homo sapiens	50-55
19414790-2	2009	Although glycans may be part of specific epitopes or shield other epitopes from T cells and Abs, this study provides evidence for a different immunomodulatory function of glycans associated with gp120 residues N230 and N448.	Polysaccharides	171-178	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	195-200
19414790-8	2009	Modifications of amino acids bearing glycans at the C termini of gp120 helper epitopes may prove to be a useful strategy for enhancing the immunogenicity of HIV-1 envelope gp120.	Polysaccharides	37-44	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	65-70
19414790-8	2009	Modifications of amino acids bearing glycans at the C termini of gp120 helper epitopes may prove to be a useful strategy for enhancing the immunogenicity of HIV-1 envelope gp120.	Polysaccharides	37-44	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	172-177
19429414-0	2009	Polysaccharide nanogel delivery of a TNF-alpha and RANKL antagonist peptide allows systemic prevention of bone loss.	Polysaccharides	0-14	tumor necrosis factor	Mus musculus	37-46
19429414-0	2009	Polysaccharide nanogel delivery of a TNF-alpha and RANKL antagonist peptide allows systemic prevention of bone loss.	Polysaccharides	0-14	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	51-56
19264785-2	2009	The potent and broadly neutralizing monoclonal antibody 2G12 binds a cluster of high-mannose-type oligosaccharides on the gp120 subunit of Env, revealing a conserved and highly exposed epitope on the glycan shield.	Polysaccharides	200-206	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	122-127
18810635-6	2009	Glycan array screening indicated that galectin-14 recognizes terminal N-acetyllactosamine residues which can be modified with alpha1-2-fucosylation and, uniquely for a galectin, prefers alpha2- over alpha2-sialylation.	Polysaccharides	0-6	galectin 14	Homo sapiens	38-49
19265195-9	2009	These results suggest that the Galbeta1-4GlcNAc structure in the HNK-1 carbohydrate is mainly synthesized by beta4GalT-II and that the glycans synthesized by beta4GalT-II have essential roles in higher brain functions, including some that are HNK-1-dependent and some that are not.	Polysaccharides	135-142	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	65-70
19265195-9	2009	These results suggest that the Galbeta1-4GlcNAc structure in the HNK-1 carbohydrate is mainly synthesized by beta4GalT-II and that the glycans synthesized by beta4GalT-II have essential roles in higher brain functions, including some that are HNK-1-dependent and some that are not.	Polysaccharides	135-142	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	243-248
19264785-2	2009	The potent and broadly neutralizing monoclonal antibody 2G12 binds a cluster of high-mannose-type oligosaccharides on the gp120 subunit of Env, revealing a conserved and highly exposed epitope on the glycan shield.	Polysaccharides	200-206	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	139-142
19264785-4	2009	2G12 binding to this protein, identified as Pst1, was enhanced by adding the Delta mnn1 deletion to the Delta pmr1 background, ensuring the exposure of terminal alpha1,2-linked mannose residues on the D1 and D3 arms of high-mannose glycans.	Polysaccharides	232-239	Pst1p	Saccharomyces cerevisiae S288C	44-48
19201177-0	2009	Hypoglycemic effect of polysaccharide enriched extract of Astragalus membranaceus in diet induced insulin resistant C57BL/6J mice and its potential mechanism.	Polysaccharides	23-37	insulin	Homo sapiens	98-105
19301818-0	2009	Hpf2 glycan structure is critical for protection against protein haze formation in white wine.	Polysaccharides	5-11	Pst1p	Saccharomyces cerevisiae S288C	0-4
19366709-1	2009	UDP-glucose pyrophosphorylase (UGPase) produces UDP-glucose which is essential for sucrose and polysaccharide synthesis.	Polysaccharides	95-109	UDP-GLUCOSE PYROPHOSPHORYLASE 1	Arabidopsis thaliana	0-29
19366709-1	2009	UDP-glucose pyrophosphorylase (UGPase) produces UDP-glucose which is essential for sucrose and polysaccharide synthesis.	Polysaccharides	95-109	UDP-GLUCOSE PYROPHOSPHORYLASE 1	Arabidopsis thaliana	31-37
19412661-12	2009	Glycoarray analysis suggested that high mannose glycan structures on fetuin A were only detectable in cancer but not normal tissue.	Polysaccharides	48-54	alpha 2-HS glycoprotein	Homo sapiens	69-77
18844296-5	2009	Glycan MS analyses in CDG-II is mandatory to detect whenever possible a repertoire of structures to pinpoint candidate enzymes and genes responsible for the abnormal N-glycan synthesis.	Polysaccharides	0-6	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	22-28
19365066-1	2009	Oligosaccharyltransferase (OT) transfers high mannose-type glycans to the nascent polypeptides that are translated by the membrane-bound ribosome and translocated into the lumen of the endoplasmic reticulum through the Sec61 translocon complex.	Polysaccharides	59-66	SEC61 translocon subunit alpha 1	Homo sapiens	219-224
19301818-5	2009	An altered glycan structure in the P. pastoris -produced protein was associated with decreased solubility in water and reduced capacity to mitigate haze formation compared to native Hpf2 protein from S. cerevisiae.	Polysaccharides	11-17	Pst1p	Saccharomyces cerevisiae S288C	182-186
19301818-6	2009	alpha-1,2-Linked mannose in the glycan chain was shown to be required for haze protective activity using a series of S. cerevisiae deletion mutants (mnn1-Delta, mnn2-Delta, mnn4-Delta, and mnn5-Delta), defective in different aspects of glycan processing.	Polysaccharides	32-38	alpha-1,3-mannosyltransferase MNN1	Saccharomyces cerevisiae S288C	149-153
19222173-6	2009	The inhibitory activities of various glycans suggest that UGGT has a strong affinity for the core pentasaccharide (Man3GlcNAc2) of high-mannose-type glycans.	Polysaccharides	37-44	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	58-62
19249311-1	2009	Multivalent binding of glycans on pathogens and on mammalian cells by the receptors DC-SIGN (CD209) and DC-SIGNR (L-SIGN, CD299) is dependent on correct disposition of the C-type carbohydrate-recognition domains projected at the C-terminal ends of necks at the cell surface.	Polysaccharides	23-30	CD209 molecule	Homo sapiens	84-91
19249311-1	2009	Multivalent binding of glycans on pathogens and on mammalian cells by the receptors DC-SIGN (CD209) and DC-SIGNR (L-SIGN, CD299) is dependent on correct disposition of the C-type carbohydrate-recognition domains projected at the C-terminal ends of necks at the cell surface.	Polysaccharides	23-30	CD209 molecule	Homo sapiens	93-98
19249311-1	2009	Multivalent binding of glycans on pathogens and on mammalian cells by the receptors DC-SIGN (CD209) and DC-SIGNR (L-SIGN, CD299) is dependent on correct disposition of the C-type carbohydrate-recognition domains projected at the C-terminal ends of necks at the cell surface.	Polysaccharides	23-30	C-type lectin domain family 4 member M	Homo sapiens	104-112
19249311-1	2009	Multivalent binding of glycans on pathogens and on mammalian cells by the receptors DC-SIGN (CD209) and DC-SIGNR (L-SIGN, CD299) is dependent on correct disposition of the C-type carbohydrate-recognition domains projected at the C-terminal ends of necks at the cell surface.	Polysaccharides	23-30	C-type lectin domain family 4 member M	Homo sapiens	114-120
19249311-1	2009	Multivalent binding of glycans on pathogens and on mammalian cells by the receptors DC-SIGN (CD209) and DC-SIGNR (L-SIGN, CD299) is dependent on correct disposition of the C-type carbohydrate-recognition domains projected at the C-terminal ends of necks at the cell surface.	Polysaccharides	23-30	C-type lectin domain family 4 member M	Homo sapiens	122-127
19222173-6	2009	The inhibitory activities of various glycans suggest that UGGT has a strong affinity for the core pentasaccharide (Man3GlcNAc2) of high-mannose-type glycans.	Polysaccharides	149-156	UDP-glucose glycoprotein glucosyltransferase 1	Homo sapiens	58-62
19558361-6	2009	These results demonstrated that cationic polysaccharide or anionic polysaccharide SOD derivatives might be useful in the prevention and treatment of ROS-mediated inflammatory diseases.	Polysaccharides	67-81	superoxide dismutase 1	Homo sapiens	82-85
19307715-6	2009	By using only the first four nonzero lowest-frequency normal modes to construct the anisotropic thermal parameters, combined with manual adjustments and standard positional refinement using REFMAC5, the structural model of the gp120 core was significantly improved in many aspects, including substantial decreases in R factors, better fitting of several flexible regions in electron-density maps, the addition of five new sugar rings at four glycan chains and an excellent correlation of the B-factor distribution with known structural flexibility.	Polysaccharides	442-448	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	227-232
19704950-0	2009	Effect of plasma lipoproteins and their complexes with polysaccharides on interleukin-1beta concentration in macrophages of mice with HA-1 ascitic hepatoma.	Polysaccharides	55-70	interleukin 1 beta	Mus musculus	74-91
19704950-4	2009	Addition of polysaccharides in combination with lipoproteins was followed by a 2-3-fold decrease in interleukin-1beta concentration.	Polysaccharides	12-27	interleukin 1 beta	Mus musculus	100-117
19122213-8	2009	Gene array analysis of the glycogenes illustrated a pattern of glycosyltransferases that matched the glycan structures found in glycoproteins and aryl-glycans formed in the PC/AA/C1/SB10C cells; however, there was no action of the three inhibitors on glycogene transcript levels.	Polysaccharides	101-107	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	179-187
19139198-11	2009	The results demonstrate that C. jejuni surface polysaccharides induce IL-6 secretion from intestinal epithelial cells via TLR-2 in a MyD88-independent manner.	Polysaccharides	47-62	interleukin 6	Homo sapiens	70-74
19307599-2	2009	In this study, we show that N-glycans, specifically core glycans, enhance the productive folding and conformational stability of a polytopic membrane protein, the cystic fibrosis transmembrane conductance regulator (CFTR), independently of lectin-like chaperones.	Polysaccharides	30-37	CF transmembrane conductance regulator	Homo sapiens	163-214
19428710-3	2009	Here, guanidinium hydrochloride-denatured hexameric leucine aminopeptidase is shown to be efficiently refolded by using the cationic detergent cetyltrimethylammonium bromide and the linear polysaccharide dextrin-10 as artificial chaperones.	Polysaccharides	189-203	carboxypeptidase Q	Homo sapiens	60-74
19307599-2	2009	In this study, we show that N-glycans, specifically core glycans, enhance the productive folding and conformational stability of a polytopic membrane protein, the cystic fibrosis transmembrane conductance regulator (CFTR), independently of lectin-like chaperones.	Polysaccharides	30-37	CF transmembrane conductance regulator	Homo sapiens	216-220
19307599-4	2009	Conformational destabilization of the glycan-deficient CFTR induces ubiquitination, leading to rapid elimination from the cell surface.	Polysaccharides	38-44	CF transmembrane conductance regulator	Homo sapiens	55-59
19267921-0	2009	The high affinity selectin glycan ligand C2-O-sLex and mRNA transcripts of the core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT1) gene are highly expressed in human colorectal adenocarcinomas.	Polysaccharides	27-33	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	128-134
19245254-6	2009	We show that the mutants (280)SGG(282) and (280)AGG(282) with the highest GalNAc-T activity can also transfer modified sugars such as 2-keto-galactose or GalNAz from their respective UDP-sugar derivatives to LacNAc moiety present at the nonreducing end of glycans of asialofetuin, thus enabling the detection of LacNAc moiety of glycoproteins and glycolipids by a chemiluminescence method.	Polysaccharides	256-263	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	74-82
19414318-0	2009	A protein-bound polysaccharide, PSK, enhances tumor suppression induced by docetaxel in a gastric cancer xenograft model.	Polysaccharides	16-30	TAO kinase 2	Homo sapiens	32-35
19218444-8	2009	Recombinant Sfrs1 protein bound to a series of fucosylated oligosaccharides in glycan array and plate-binding assays.	Polysaccharides	79-85	serine and arginine-rich splicing factor 1	Mus musculus	12-17
19118161-7	2009	PCLP on CD44-knockdown LS174T cells exhibits higher HECA-452 immunoreactivity than PCLP on wild-type cells, suggesting that PCLP functions as an alternative acceptor for selectin-binding glycans.	Polysaccharides	187-194	podocalyxin like	Homo sapiens	0-4
19118161-7	2009	PCLP on CD44-knockdown LS174T cells exhibits higher HECA-452 immunoreactivity than PCLP on wild-type cells, suggesting that PCLP functions as an alternative acceptor for selectin-binding glycans.	Polysaccharides	187-194	CD44 molecule (Indian blood group)	Homo sapiens	8-12
19118161-7	2009	PCLP on CD44-knockdown LS174T cells exhibits higher HECA-452 immunoreactivity than PCLP on wild-type cells, suggesting that PCLP functions as an alternative acceptor for selectin-binding glycans.	Polysaccharides	187-194	selectin P	Homo sapiens	170-178
19414318-2	2009	In addition, we have also shown that a protein-bound polysaccharide PSK enhances TXT-induced apoptosis through NF-kappaB inhibition in human pancreatic cancer cells.	Polysaccharides	53-67	TAO kinase 2	Homo sapiens	68-71
19414318-2	2009	In addition, we have also shown that a protein-bound polysaccharide PSK enhances TXT-induced apoptosis through NF-kappaB inhibition in human pancreatic cancer cells.	Polysaccharides	53-67	nuclear factor kappa B subunit 1	Homo sapiens	111-120
19016779-0	2009	Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2.	Polysaccharides	27-41	C-X-C motif chemokine ligand 8	Homo sapiens	72-76
19014994-0	2009	Structural characterization and comparative modeling of PD-Ls 1-3, type 1 ribosome-inactivating proteins from summer leaves of Phytolacca dioica L. The amino acid sequence and glycan structure of PD-L1, PD-L2 and PD-L3, type 1 ribosome-inactivating proteins isolated from Phytolacca dioica L. leaves, were determined using a combined approach based on peptide mapping, Edman degradation and ESI-Q-TOF MS in precursor ion discovery mode.	Polysaccharides	176-182	CD274 molecule	Homo sapiens	196-201
19016779-0	2009	Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2.	Polysaccharides	27-41	toll like receptor 2	Homo sapiens	134-138
19223512-7	2009	The sensitivity of six individual glycans evaluated for separation of HCC cases from population controls ranged from 73% to 90%, and the specificity ranged from 36% to 91%.	Polysaccharides	34-41	HCC	Homo sapiens	70-73
19223512-9	2009	The three N-glycans remained associated with HCC after adjustment for chronic viral infection and other known covariates, whereas the other glycans increased significantly at earlier stages of the progression of chronic viral infection to HCC.	Polysaccharides	12-19	HCC	Homo sapiens	45-48
19178537-8	2009	Despite only modest homology, both Siglec-8 and Siglec-F preferentially recognize a sulphated glycan ligand closely related to sialyl Lewis X, a common ligand for the selectin family of adhesion molecules.	Polysaccharides	94-100	sialic acid binding Ig like lectin 8	Homo sapiens	35-43
19178537-8	2009	Despite only modest homology, both Siglec-8 and Siglec-F preferentially recognize a sulphated glycan ligand closely related to sialyl Lewis X, a common ligand for the selectin family of adhesion molecules.	Polysaccharides	94-100	sialic acid binding Ig-like lectin F	Mus musculus	48-56
19189310-4	2009	We report that DMBT1 directly interacts with dextran sulfate sodium (DSS) and carrageenan, a structurally similar sulfated polysaccharide, which is used as a texturizer and thickener in human dietary products.	Polysaccharides	123-137	deleted in malignant brain tumors 1	Homo sapiens	15-20
19235718-4	2009	Presynaptically secreted MTG recruits and reorganizes secreted carbohydrates, and acts to recruit synaptic integrins and ECM glycans.	Polysaccharides	125-132	mind the gap	Drosophila melanogaster	25-28
19043084-6	2009	This was illustrated by comparing the LC-MS spectra of MUC7 and MUC5B glycans from secretors (23 individuals) and nonsecretors (6 individuals).	Polysaccharides	70-77	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	64-69
19281531-4	2009	IC31 significantly enhanced IgG1, IgG2a and IgG2b antibodies (Ab) to the serotype 1 polysaccharide.	Polysaccharides	84-98	LOC105243590	Mus musculus	28-32
19079358-8	2009	TLR9 bound to CpG DNA had glycan modifications indicative of Golgi processing confirming that TLR9 travels through the Golgi complex to access CpG DNA in endolysosomes.	Polysaccharides	26-32	toll like receptor 9	Homo sapiens	0-4
19079358-8	2009	TLR9 bound to CpG DNA had glycan modifications indicative of Golgi processing confirming that TLR9 travels through the Golgi complex to access CpG DNA in endolysosomes.	Polysaccharides	26-32	toll like receptor 9	Homo sapiens	94-98
19178301-6	2009	Using our system, we successfully identified glycan alterations on alpha-fetoprotein (AFP), including a novel LacdiNAc structure in addition to previously reported alterations such as alpha1,6 fucosylation.	Polysaccharides	45-51	alpha fetoprotein	Homo sapiens	67-84
19178301-6	2009	Using our system, we successfully identified glycan alterations on alpha-fetoprotein (AFP), including a novel LacdiNAc structure in addition to previously reported alterations such as alpha1,6 fucosylation.	Polysaccharides	45-51	alpha fetoprotein	Homo sapiens	86-89
19210702-3	2009	The studies reported here show that SEC6 RNAi mutant strains were defective in a number of virulence factors including laccase, urease as well as soluble polysaccharide and demonstrated attenuated virulence in mice.	Polysaccharides	154-168	exocyst complex component 3	Mus musculus	36-40
19162326-0	2009	Characterization of murine MGL1 and MGL2 C-type lectins: distinct glycan specificities and tumor binding properties.	Polysaccharides	66-72	C-type lectin domain family 10, member A	Mus musculus	27-31
19162326-0	2009	Characterization of murine MGL1 and MGL2 C-type lectins: distinct glycan specificities and tumor binding properties.	Polysaccharides	66-72	macrophage galactose N-acetyl-galactosamine specific lectin 2	Mus musculus	36-40
19162326-4	2009	Here, we set out to determine the glycan specificity of the murine homologues, MGL1 and MGL2, using a glycan array.	Polysaccharides	34-40	C-type lectin domain family 10, member A	Mus musculus	79-83
19162326-4	2009	Here, we set out to determine the glycan specificity of the murine homologues, MGL1 and MGL2, using a glycan array.	Polysaccharides	34-40	macrophage galactose N-acetyl-galactosamine specific lectin 2	Mus musculus	88-92
19162326-4	2009	Here, we set out to determine the glycan specificity of the murine homologues, MGL1 and MGL2, using a glycan array.	Polysaccharides	102-108	C-type lectin domain family 10, member A	Mus musculus	79-83
19162326-4	2009	Here, we set out to determine the glycan specificity of the murine homologues, MGL1 and MGL2, using a glycan array.	Polysaccharides	102-108	macrophage galactose N-acetyl-galactosamine specific lectin 2	Mus musculus	88-92
19191477-8	2009	The structure of BT1043 complexed with N-acetyllactosamine reveals that recognition is mediated via hydrogen bonding interactions with the reducing end of beta-N-acetylglucosamine, suggesting a role in binding glycans liberated from the mucin polypeptide.	Polysaccharides	210-217	LOC100508689	Homo sapiens	237-242
19191477-9	2009	This is in contrast to CBM 32 family members that target the terminal nonreducing galactose residue of mucin glycans.	Polysaccharides	109-116	LOC100508689	Homo sapiens	103-108
18822097-0	2009	A GYS1 gene mutation is highly associated with polysaccharide storage myopathy in Cob Normand draught horses.	Polysaccharides	47-61	glycogen synthase 1	Equus caballus	2-6
19128029-1	2009	Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, binds specifically to poly-N-acetyllactosamine-enriched glycoconjugates.	Polysaccharides	69-75	galectin 1	Homo sapiens	0-10
19128029-1	2009	Galectin-1 (Gal-1), a member of a family of evolutionarily conserved glycan-binding proteins, binds specifically to poly-N-acetyllactosamine-enriched glycoconjugates.	Polysaccharides	69-75	galectin 1	Homo sapiens	12-17
19140690-3	2009	The close and multivalent arrangement of the endogenous reducing agent (alditols) on the polysaccharide backbone resulted in the formation of silver nanoparticles (phi &lt; 10 nm), which induced a considerable SERS effect and led to hydrogel formation.	Polysaccharides	89-103	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	210-214
19095040-0	2009	The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumoniae.	Polysaccharides	90-105	C-type lectin domain family 4 member M	Rattus norvegicus	18-24
19026722-3	2009	We have compared the interaction of P-selectin with several low molecular weight polysaccharides: fucoidan, heparin and dextran sulfate.	Polysaccharides	81-96	selectin P	Homo sapiens	36-46
19026722-6	2009	Kd were obtained from surface plasmon resonance experiments with immobilized P-selectin constructs, polysaccharides being injected in the mobile phase.	Polysaccharides	100-115	selectin P	Homo sapiens	77-87
19026722-9	2009	It exhibited the highest affinity for immobilized P-selectin with a KD of 1.2 nM, two orders of magnitude greater than the K(D) of the other polysaccharides.	Polysaccharides	141-156	selectin P	Homo sapiens	50-60
19230080-5	2009	Lewis antigen glycans, present in human milk, bind to DC-SIGN and inhibit HIV-1 transfer to CD4 + T lymphocytes.	Polysaccharides	14-21	CD209 molecule	Homo sapiens	54-61
19230080-9	2009	Identifying the specific milk oligosaccharides that interact with DC-SIGN may guide the development of glycan-based drugs that prevent transmission of HIV-1 and other pathogens that use DC-SIGN as an entry point.	Polysaccharides	103-109	CD209 molecule	Homo sapiens	66-73
19230080-9	2009	Identifying the specific milk oligosaccharides that interact with DC-SIGN may guide the development of glycan-based drugs that prevent transmission of HIV-1 and other pathogens that use DC-SIGN as an entry point.	Polysaccharides	103-109	CD209 molecule	Homo sapiens	186-193
18950867-6	2009	Consistent with the loss of MZ B cells, the production of antigen-specific IgM antibodies following immunization with pneumococcal polysaccharides was severely impaired in Sly1(d/d) mice.	Polysaccharides	131-146	SAM and SH3 domain containing 3	Mus musculus	172-176
19128049-7	2009	The glycans identified in these studies will allow for more defined targeting of prostate disease-specific changes for PAP, PSA and other secreted prostatic glycoproteins.	Polysaccharides	4-11	kallikrein related peptidase 3	Homo sapiens	124-127
19140676-6	2009	We have found that the concentrations of two glycans (NGA2F and NA2) and their logarithm ratio of NGA2F versus NA2 (named GlycoNashTest) were associated with the degree of NASH-related fibrosis, but had no correlation with the grade of inflammation nor steatosis severity.	Polysaccharides	45-52	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	172-176
19099505-3	2009	The biantennary glycans containing antenna alpha1,3/4 fucose or alpha1,6 core fucose showed different fragmentation behaviors in collision-induced dissociation of protonated glycopeptides.	Polysaccharides	16-23	adrenoceptor alpha 1D	Homo sapiens	43-51
19099505-3	2009	The biantennary glycans containing antenna alpha1,3/4 fucose or alpha1,6 core fucose showed different fragmentation behaviors in collision-induced dissociation of protonated glycopeptides.	Polysaccharides	16-23	adrenoceptor alpha 1D	Homo sapiens	64-72
19084021-8	2009	We propose a model in which OS-9 recognises terminally misfolded proteins via polypeptide-based rather than glycan-based signals, but is only required for transferring those bearing N-glycans to the ubiquitination machinery.	Polysaccharides	108-114	OS9 endoplasmic reticulum lectin	Homo sapiens	28-32
19056285-1	2009	l-Rhamnose (Rha) is an important constituent of pectic polysaccharides, a major component of the cell walls of Arabidopsis, which is synthesized by three enzymes encoded by AtRHM1, AtRHM2/AtMUM4, and AtRHM3.	Polysaccharides	55-70	rhamnose biosynthesis 1	Arabidopsis thaliana	173-179
19056285-1	2009	l-Rhamnose (Rha) is an important constituent of pectic polysaccharides, a major component of the cell walls of Arabidopsis, which is synthesized by three enzymes encoded by AtRHM1, AtRHM2/AtMUM4, and AtRHM3.	Polysaccharides	55-70	NAD-dependent epimerase/dehydratase family protein	Arabidopsis thaliana	181-187
19056285-1	2009	l-Rhamnose (Rha) is an important constituent of pectic polysaccharides, a major component of the cell walls of Arabidopsis, which is synthesized by three enzymes encoded by AtRHM1, AtRHM2/AtMUM4, and AtRHM3.	Polysaccharides	55-70	NAD-dependent epimerase/dehydratase family protein	Arabidopsis thaliana	188-194
19056285-1	2009	l-Rhamnose (Rha) is an important constituent of pectic polysaccharides, a major component of the cell walls of Arabidopsis, which is synthesized by three enzymes encoded by AtRHM1, AtRHM2/AtMUM4, and AtRHM3.	Polysaccharides	55-70	rhamnose biosynthesis 3	Arabidopsis thaliana	200-206
19055607-4	2009	All secreted forms of AACT were N-glycosylated, with the presence of complex glycans as observed naturally on human AACT.	Polysaccharides	77-84	serpin family A member 3	Homo sapiens	22-26
19055607-4	2009	All secreted forms of AACT were N-glycosylated, with the presence of complex glycans as observed naturally on human AACT.	Polysaccharides	77-84	serpin family A member 3	Homo sapiens	116-120
19055608-8	2009	Confocal microscopy showed that apoplast and ER-targeted EPO were correctly localized, and N-glycan analysis demonstrated that complex plant glycans existed on apoplast-targeted EPO, but not on ER-targeted EPO.	Polysaccharides	141-148	erythropoietin	Homo sapiens	178-181
19055608-8	2009	Confocal microscopy showed that apoplast and ER-targeted EPO were correctly localized, and N-glycan analysis demonstrated that complex plant glycans existed on apoplast-targeted EPO, but not on ER-targeted EPO.	Polysaccharides	141-148	erythropoietin	Homo sapiens	178-181
19171304-4	2009	Fluorescence-based screening demonstrated that Gal-1 recognizes a wide variety of complex N-glycans, whereas Gal-3 primarily recognizes poly-N-acetyllactosamine-containing glycans independent of N-glycan presentation.	Polysaccharides	92-99	galectin 1	Homo sapiens	47-52
20641701-13	2004	Arabinogalactan, a polysaccharide, binds specifically to hepatocytes via asialoglycoprotein receptor (ASGP-R) (4-6).	Polysaccharides	19-33	asialoglycoprotein receptor 1	Homo sapiens	102-109
20407596-0	2009	Analysis of Recombinant CD24 Glycans by MALDI-TOF-MS Reveals Prevalence of Sialyl-T Antigen.	Polysaccharides	29-36	CD24 molecule	Homo sapiens	24-28
19799114-7	2009	CRP binds to modified low-density lipoproteins, bacterial polysaccharides, apoptotic cells, and nuclear materials.	Polysaccharides	58-73	C-reactive protein, pentraxin-related	Mus musculus	0-3
19243740-0	2009	Polysaccharide fraction of Agaricus brasiliensis avoids tumor-induced IL-10 production and changes the microenvironment of subcutaneous Ehrlich adenocarcinoma.	Polysaccharides	0-14	interleukin 10	Mus musculus	70-75
19319847-1	2009	Serglycin (SG), like all other proteoglycans, consists of a protein "core" to which sulfated and thereby negatively charged polysaccharide chains of glycosaminoglycan type are attached.	Polysaccharides	124-138	serglycin	Mus musculus	0-9
19319847-1	2009	Serglycin (SG), like all other proteoglycans, consists of a protein "core" to which sulfated and thereby negatively charged polysaccharide chains of glycosaminoglycan type are attached.	Polysaccharides	124-138	serglycin	Mus musculus	11-13
18539357-2	2009	Tumor MUC1 differs from normal MUC1 by modified glycan side chains.	Polysaccharides	48-54	mucin 1, cell surface associated	Homo sapiens	6-10
19309568-8	2009	Notably, galectin-3, but not galectin-1 binding, was substantially increased in intraepithelial gut lymphocytes of allergic patients compared to non-allergic subjects, suggesting a potential role of galectin-3-glycan interactions in shaping epithelial-immune cell connections during allergic inflammatory processes.	Polysaccharides	210-216	galectin 3	Homo sapiens	199-209
19325165-11	2009	The cytosolic metabolism of the neutral sugars includes the action of a hexokinase, a phosphoglucomutase, and a transglucosidase that utilizes high molecular weight glycans as a transient glucosyl acceptor or donor.	Polysaccharides	165-172	hexokinase 1	Homo sapiens	72-82
19402404-9	2009	Further investigation suggested that CST was affected by soluble PN, soluble PN/PS, and particle sizes of sludge flocs, but was affected slightly by total PN, PS, or PN/PS in the whole sludge flocs and other fractions (except slime).	Polysaccharides	80-82	cystatin 12, pseudogene	Homo sapiens	37-40
19402404-9	2009	Further investigation suggested that CST was affected by soluble PN, soluble PN/PS, and particle sizes of sludge flocs, but was affected slightly by total PN, PS, or PN/PS in the whole sludge flocs and other fractions (except slime).	Polysaccharides	159-161	cystatin 12, pseudogene	Homo sapiens	37-40
19402404-9	2009	Further investigation suggested that CST was affected by soluble PN, soluble PN/PS, and particle sizes of sludge flocs, but was affected slightly by total PN, PS, or PN/PS in the whole sludge flocs and other fractions (except slime).	Polysaccharides	159-161	cystatin 12, pseudogene	Homo sapiens	37-40
19152248-1	2009	The present investigation was a lectin-based diagnosis of malignant prostate cancer (PC) by the interaction of phytohemagglutinin (PHA lectin) from Phaseolus vulgaris with the glycan part of serum prostate specific antigen (PSA) of patients with prostatic disorder.	Polysaccharides	176-182	kallikrein related peptidase 3	Homo sapiens	197-222
19056269-0	2009	Polysaccharide storage myopathy phenotype in quarter horse-related breeds is modified by the presence of an RYR1 mutation.	Polysaccharides	0-14	ryanodine receptor 1	Equus caballus	108-112
19056269-1	2009	In this study we examined a family of Quarter Horses with Polysaccharide Storage Myopathy (PSSM) with a dominant mutation in the skeletal muscle glycogen synthase (GYS1) gene.	Polysaccharides	58-72	glycogen synthase 1	Equus caballus	164-168
19430179-1	2009	The echinocandin (candin) class of antifungal drugs inhibit beta-1,3-glucan synthase and block synthesis of beta-1,3-glucan , an important polysaccharide in fungal cell walls.	Polysaccharides	139-153	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	108-116
18677561-10	2009	E-selectin, which ligand was modified by beta1,4-GalT-I, was correlated with galactose-containing glycans following injecting LPS into spinal cord.	Polysaccharides	98-105	selectin, endothelial cell	Mus musculus	0-10
18677561-10	2009	E-selectin, which ligand was modified by beta1,4-GalT-I, was correlated with galactose-containing glycans following injecting LPS into spinal cord.	Polysaccharides	98-105	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	Mus musculus	41-53
18677561-10	2009	E-selectin, which ligand was modified by beta1,4-GalT-I, was correlated with galactose-containing glycans following injecting LPS into spinal cord.	Polysaccharides	98-105	toll-like receptor 4	Mus musculus	126-129
18981244-3	2009	One such CLR, dendritic cell-specific intracellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN; CD209), has been shown to recognize glycans expressed by S. mansoni eggs.	Polysaccharides	139-146	CD209a antigen	Mus musculus	94-101
19115042-1	2009	OBJECTIVE: Curdlan, an extracellular bacterial polysaccharide, is a linear beta-1,3-glucan.	Polysaccharides	47-61	hemoglobin, beta adult major chain	Mus musculus	75-83
19415110-0	2009	Insight into the regulation of glycan synthesis in Drosophila chaoptin based on mass spectrometry.	Polysaccharides	31-37	chaoptin	Drosophila melanogaster	62-70
18778316-1	2009	Plant N-linked glycans differ substantially from their mammalian counterparts, mainly with respect to modifications of the core glycan, which typically contains a beta(1,2)-xylose and an alpha(1,3)-fucose.	Polysaccharides	15-21	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	163-171
18778316-1	2009	Plant N-linked glycans differ substantially from their mammalian counterparts, mainly with respect to modifications of the core glycan, which typically contains a beta(1,2)-xylose and an alpha(1,3)-fucose.	Polysaccharides	15-21	adrenoceptor alpha 1D	Homo sapiens	187-196
19415110-8	2009	Furthermore, analysis of Chp from a mutant (RNAi against dolichyl-phosphate alpha-d-mannosyltransferase), which affects N-glycan synthesis in the ER, revealed that truncated glycan structures were processed.	Polysaccharides	122-128	chaoptin	Drosophila melanogaster	25-28
18930512-4	2008	With a few exceptions, the more glycans were deleted in the gp120 V1/V2 domain, the more the replication capacity of the mutant viruses became compromised.	Polysaccharides	32-39	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	60-65
21822362-4	2009	We show here that anti-DeNAc mAbs, DA1 and DA2 (both IgM), are reactive with polysaccharides containing Neu, bind to group B, C, W135 and Y but not X strains grown in chemically defined media (CDM).	Polysaccharides	77-92	immunoglobulin heavy diversity 4-11 (non-functional)	Homo sapiens	35-38
18849568-0	2008	Significance of NF-kappaB/GATA axis in tumor necrosis factor-alpha-induced expression of 6-sulfated cell recognition glycans in human T-lymphocytes.	Polysaccharides	117-124	nuclear factor kappa B subunit 1	Homo sapiens	16-25
18849568-0	2008	Significance of NF-kappaB/GATA axis in tumor necrosis factor-alpha-induced expression of 6-sulfated cell recognition glycans in human T-lymphocytes.	Polysaccharides	117-124	glutaminyl-tRNA amidotransferase subunit QRSL1	Homo sapiens	26-30
18849568-0	2008	Significance of NF-kappaB/GATA axis in tumor necrosis factor-alpha-induced expression of 6-sulfated cell recognition glycans in human T-lymphocytes.	Polysaccharides	117-124	tumor necrosis factor	Homo sapiens	39-66
18848522-7	2008	Combined with structural information of the glycans of C. elegans, these results suggest that CLEC-79 preferentially binds to O-glycans in vivo.	Polysaccharides	44-51	C-type lectin domain-containing protein	Caenorhabditis elegans	94-101
18930512-0	2008	Glycan deletions in the HIV-1 gp120 V1/V2 domain compromise viral infectivity, sensitize the mutant virus strains to carbohydrate-binding agents and represent a specific target for therapeutic intervention.	Polysaccharides	0-6	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	30-35
19050242-0	2008	A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine.	Polysaccharides	84-98	inducible T cell co-stimulator	Mus musculus	8-12
19050242-0	2008	A novel ICOS-independent, but CD28- and SAP-dependent, pathway of T cell-dependent, polysaccharide-specific humoral immunity in response to intact Streptococcus pneumoniae versus pneumococcal conjugate vaccine.	Polysaccharides	84-98	SH2 domain containing 1A	Mus musculus	40-43
18755300-2	2008	Here, we report that polysaccharide-protein complex from L. barbarum (LBP) is able to activate T cells.	Polysaccharides	21-35	lipopolysaccharide binding protein	Mus musculus	70-73
18930512-7	2008	Our data may provide an explanation why glycan deletions in the gp120 V1/V2 domain rarely occur under CBA pressure and confirm the important functional role of the glycans in the HIV-1 gp120 V1/V2 domain.	Polysaccharides	40-46	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	64-69
18930512-7	2008	Our data may provide an explanation why glycan deletions in the gp120 V1/V2 domain rarely occur under CBA pressure and confirm the important functional role of the glycans in the HIV-1 gp120 V1/V2 domain.	Polysaccharides	164-171	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	64-69
18930512-7	2008	Our data may provide an explanation why glycan deletions in the gp120 V1/V2 domain rarely occur under CBA pressure and confirm the important functional role of the glycans in the HIV-1 gp120 V1/V2 domain.	Polysaccharides	164-171	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	185-190
18930512-8	2008	The gp120 V1/V2 loop glycans of HIV-1 should therefore be considered as a hot spot and novel target for specific therapeutic drug intervention.	Polysaccharides	21-28	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	4-9
18841980-0	2008	Polysaccharides from Dioscorea batatas induce tumor necrosis factor-alpha secretion via Toll-like receptor 4-mediated protein kinase signaling pathways.	Polysaccharides	0-15	tumor necrosis factor	Mus musculus	46-73
18796645-5	2008	Frontal affinity chromatography showed that the sugar-binding specificity and affinity of Gal-1 for model glycans were barely affected by the mutagenesis.	Polysaccharides	106-113	galectin 1	Homo sapiens	90-95
18812188-1	2008	This paper concerns the interaction between hyaluronan and fibrinogen as model for protein-polysaccharide interaction.	Polysaccharides	91-105	fibrinogen beta chain	Homo sapiens	59-69
18953356-1	2008	The glycan determinant CD15 (also known as Lewis x, or Le(x)) is a distinguishing marker for human myeloid cells and mediates neutrophil adhesion to dendritic cells.	Polysaccharides	4-10	fucosyltransferase 4	Homo sapiens	23-27
18953356-4	2008	Flow cytometric analysis of differentiating cells together with biochemical studies using inhibitors of glycan synthesis and of sialidases showed that increased CD15 expression is not due to de novo biosynthesis of CD15, but results predominantly from induction of alpha(2-3)-sialidase activity, which yields CD15 from cell-surface sialyl-CD15 (also known as sialyl-Lewis x, sLe(x) or CD15s).	Polysaccharides	104-110	fucosyltransferase 4	Homo sapiens	161-165
18981104-1	2008	Polysialic acid (polySia) is a large glycan with restricted expression, typically found attached to the protein scaffold neural cell adhesion molecule (NCAM).	Polysaccharides	37-43	neural cell adhesion molecule 1	Mus musculus	121-150
18981104-1	2008	Polysialic acid (polySia) is a large glycan with restricted expression, typically found attached to the protein scaffold neural cell adhesion molecule (NCAM).	Polysaccharides	37-43	neural cell adhesion molecule 1	Mus musculus	152-156
18818422-6	2008	In 10 patients monitored longitudinally, we showed a positive correlation between this glycan marker and disease progression and also demonstrated its potential as a better indicator of metastasis compared to the currently used biomarkers, CA 15-3 and carcinoembryonic antigen (CEA).	Polysaccharides	87-93	CEA cell adhesion molecule 3	Homo sapiens	252-276
18818422-6	2008	In 10 patients monitored longitudinally, we showed a positive correlation between this glycan marker and disease progression and also demonstrated its potential as a better indicator of metastasis compared to the currently used biomarkers, CA 15-3 and carcinoembryonic antigen (CEA).	Polysaccharides	87-93	CEA cell adhesion molecule 3	Homo sapiens	278-281
18818422-7	2008	A pilot glycoproteomic study of advanced breast cancer serum highlighted acute-phase proteins alpha1-acid glycoprotein, alpha1-antichymotrypsin, and haptoglobin beta-chain as contributors to the increase in the glycan marker which, when quantified from each of these proteins, marked the onset of metastasis in advance of the CA 15-3 marker.	Polysaccharides	211-217	serpin family A member 3	Homo sapiens	120-143
18818422-7	2008	A pilot glycoproteomic study of advanced breast cancer serum highlighted acute-phase proteins alpha1-acid glycoprotein, alpha1-antichymotrypsin, and haptoglobin beta-chain as contributors to the increase in the glycan marker which, when quantified from each of these proteins, marked the onset of metastasis in advance of the CA 15-3 marker.	Polysaccharides	211-217	mucin 1, cell surface associated	Homo sapiens	326-333
19526097-0	2008	Effects of plant water-soluble polysaccharides on the production of immunoglobulins E and G1 by lymphocytes of mice sensitized with ovalbumin.	Polysaccharides	31-46	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	132-141
18928317-1	2008	The effect on the adsorbed layer properties of the modification of alpha S1-casein by covalent bonding with an uncharged polysaccharide side chain has been investigated using lattice-based self-consistent field (SCF) theory.	Polysaccharides	121-135	casein alpha s1	Homo sapiens	67-82
18928317-3	2008	While the interactions of the unmodified alpha S1-casein layers become attractive at high ionic strength, it has been shown that the presence of polysaccharide attachment to the alpha S1-casein molecule can confer net repulsive interactions over a wide range of salt concentration.	Polysaccharides	145-159	casein alpha s1	Homo sapiens	178-193
19526097-1	2008	Were studied the effects of water-soluble plant polysaccharides isolated from pharmacopoeic raw material on anaphylactic shock and production of IgE and IgG1 by lymphocytes from mice immunized with ovalbumin.	Polysaccharides	48-63	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	198-207
18656438-2	2008	Most of the glycans have only a single GlcNAc at their reducing termini (Gn1 glycans), whereas the original N-glycans retain N,N"-diacetylchitobiose at their reducing termini (Gn2 glycans).	Polysaccharides	12-19	glycogenin 1	Homo sapiens	73-76
18343922-1	2008	The protein-bound polysaccharide isolated from basidiomycetes (PSK), a biological response modifier, has been used as immunotherapeutic agent for the treatment of cancers.	Polysaccharides	18-32	TAO kinase 2	Mus musculus	63-66
19122522-5	2008	Upon recognition of capsular polysaccharide antigens of commensal bacteria by dendritic cells (through toll-like receptor 2), innate immune responses facilitate and act in conjunction with adaptive responses to promote optimal Th1 polarization.	Polysaccharides	29-43	toll like receptor 2	Homo sapiens	103-123
19122522-5	2008	Upon recognition of capsular polysaccharide antigens of commensal bacteria by dendritic cells (through toll-like receptor 2), innate immune responses facilitate and act in conjunction with adaptive responses to promote optimal Th1 polarization.	Polysaccharides	29-43	negative elongation factor complex member C/D	Homo sapiens	227-230
18924218-6	2008	We show that the polysaccharide capsule of GBS and the surface M protein of S. pyogenes, two important virulence factors, prevent SR-A-mediated non-opsonic phagocytosis of streptococci.	Polysaccharides	17-31	macrophage scavenger receptor 1	Mus musculus	130-134
18697918-7	2008	The dissociation constants of LEC-6 for these glycans were measured by frontal affinity chromatography.	Polysaccharides	46-53	Galectin	Caenorhabditis elegans	30-35
18931303-2	2008	The products of polysaccharide fermentation include short-chain fatty acids that are ligands for Gpr41, a G protein-coupled receptor expressed by a subset of enteroendocrine cells in the gut epithelium.	Polysaccharides	16-30	free fatty acid receptor 3	Homo sapiens	97-102
18815382-6	2008	In the same way, water-soluble polysaccharides that accumulate in the isa1-1 isa3-1 and isa1-1 isa3-1 pu1-1 genotypes display strongly modified structure compared to those found in isa1-1.	Polysaccharides	31-46	isoamylase 1	Arabidopsis thaliana	70-74
18815382-6	2008	In the same way, water-soluble polysaccharides that accumulate in the isa1-1 isa3-1 and isa1-1 isa3-1 pu1-1 genotypes display strongly modified structure compared to those found in isa1-1.	Polysaccharides	31-46	isoamylase 3	Arabidopsis thaliana	77-81
18815382-6	2008	In the same way, water-soluble polysaccharides that accumulate in the isa1-1 isa3-1 and isa1-1 isa3-1 pu1-1 genotypes display strongly modified structure compared to those found in isa1-1.	Polysaccharides	31-46	isoamylase 1	Arabidopsis thaliana	88-92
18815382-6	2008	In the same way, water-soluble polysaccharides that accumulate in the isa1-1 isa3-1 and isa1-1 isa3-1 pu1-1 genotypes display strongly modified structure compared to those found in isa1-1.	Polysaccharides	31-46	isoamylase 3	Arabidopsis thaliana	95-99
18815382-6	2008	In the same way, water-soluble polysaccharides that accumulate in the isa1-1 isa3-1 and isa1-1 isa3-1 pu1-1 genotypes display strongly modified structure compared to those found in isa1-1.	Polysaccharides	31-46	limit dextrinase	Arabidopsis thaliana	102-105
18815382-6	2008	In the same way, water-soluble polysaccharides that accumulate in the isa1-1 isa3-1 and isa1-1 isa3-1 pu1-1 genotypes display strongly modified structure compared to those found in isa1-1.	Polysaccharides	31-46	isoamylase 1	Arabidopsis thaliana	88-92
18815382-7	2008	Taken together, these results show that in addition to its established function in polysaccharide degradation, the activity of ISA3 is partially redundant to that of ISA1 for starch synthesis.	Polysaccharides	83-97	isoamylase 3	Arabidopsis thaliana	127-131
18656438-3	2008	Under the conditions of high-performance liquid chromatography (HPLC) mapping established for pyridylamine (PA)-labeled Gn2 N-glycans, Gn1 glycans are not well retained on reversed-phase HPLC, making simultaneous analysis of Gn1 and Gn2 glycans problematic.	Polysaccharides	126-133	glycogenin 2	Homo sapiens	120-123
18656438-3	2008	Under the conditions of high-performance liquid chromatography (HPLC) mapping established for pyridylamine (PA)-labeled Gn2 N-glycans, Gn1 glycans are not well retained on reversed-phase HPLC, making simultaneous analysis of Gn1 and Gn2 glycans problematic.	Polysaccharides	126-133	glycogenin 1	Homo sapiens	135-138
18656438-4	2008	We introduced a dual gradient (i.e., pH and butanol gradient) for the separation of Gn1 and Gn2 glycans in a single reversed-phase HPLC.	Polysaccharides	96-103	glycogenin 2	Homo sapiens	92-95
18656438-5	2008	Determination of elution time for various standard Gn2 high-mannose-type glycans, as well as Gn1 glycans found in the cytosol of animal cells, showed that elution of Gn1 and Gn2 glycans could be separated.	Polysaccharides	73-80	glycogenin 2	Homo sapiens	174-177
18656438-5	2008	Determination of elution time for various standard Gn2 high-mannose-type glycans, as well as Gn1 glycans found in the cytosol of animal cells, showed that elution of Gn1 and Gn2 glycans could be separated.	Polysaccharides	97-104	glycogenin 1	Homo sapiens	166-169
18656438-5	2008	Determination of elution time for various standard Gn2 high-mannose-type glycans, as well as Gn1 glycans found in the cytosol of animal cells, showed that elution of Gn1 and Gn2 glycans could be separated.	Polysaccharides	97-104	glycogenin 2	Homo sapiens	174-177
18656438-5	2008	Determination of elution time for various standard Gn2 high-mannose-type glycans, as well as Gn1 glycans found in the cytosol of animal cells, showed that elution of Gn1 and Gn2 glycans could be separated.	Polysaccharides	97-104	glycogenin 1	Homo sapiens	166-169
18656438-5	2008	Determination of elution time for various standard Gn2 high-mannose-type glycans, as well as Gn1 glycans found in the cytosol of animal cells, showed that elution of Gn1 and Gn2 glycans could be separated.	Polysaccharides	97-104	glycogenin 2	Homo sapiens	174-177
18656438-7	2008	This HPLC, therefore, is a powerful method for identification of the structures of PA-labeled glycans, especially Gn1-type glycans, isolated from the cytosol of animal cells.	Polysaccharides	123-130	glycogenin 1	Homo sapiens	114-117
18689872-3	2008	Because NF-kappaB signaling plays a critical role in the molecular pathogenesis of colitis-associated cancer (CAC), we reasoned that carboxylated glycans, RAGE and its ligands might promote CAC.	Polysaccharides	146-153	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	8-17
18703501-7	2008	Mass spectrometry experiments showed that CA IX contains an intramolecular disulfide bridge (Cys(119)-Cys(299)) and a unique N-linked glycosylation site (Asn(309)) that bears high mannose-type glycan structures.	Polysaccharides	193-199	carbonic anhydrase 9	Homo sapiens	42-47
18757479-4	2008	We examined the influence of 5"-AMP-activated protein kinase (AMPK) on glucose entry and glycogen synthase as a means of regulating the accumulation of this stored polysaccharide.	Polysaccharides	164-178	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	62-66
18803404-2	2008	The association of calnexin and calreticulin with the glycoproteins is regulated by ER glucosidase II, which hydrolyzes Glc 2Man X GlcNAc 2 glycans to Glc 1Man X GlcNAc 2 and further to Glc 0Man X GlcNAc 2 ( X represents any number between 5 and 9).	Polysaccharides	140-147	calnexin	Homo sapiens	19-27
18803404-2	2008	The association of calnexin and calreticulin with the glycoproteins is regulated by ER glucosidase II, which hydrolyzes Glc 2Man X GlcNAc 2 glycans to Glc 1Man X GlcNAc 2 and further to Glc 0Man X GlcNAc 2 ( X represents any number between 5 and 9).	Polysaccharides	140-147	calreticulin	Homo sapiens	32-44
18803404-3	2008	To gain new insights into the reaction mechanism of glucosidase II, we developed a kinetic model that describes the interactions between glucosidase II, calnexin/calreticulin, and the glycans.	Polysaccharides	184-191	calnexin	Homo sapiens	153-161
18803404-3	2008	To gain new insights into the reaction mechanism of glucosidase II, we developed a kinetic model that describes the interactions between glucosidase II, calnexin/calreticulin, and the glycans.	Polysaccharides	184-191	calreticulin	Homo sapiens	162-174
18803404-12	2008	We discuss the possibility that nonglucosylated glycans, existing in the ER, might regulate the entry of newly synthesized glycoproteins into the calnexin/calreticulin cycle.	Polysaccharides	48-55	calnexin	Homo sapiens	146-154
18803404-12	2008	We discuss the possibility that nonglucosylated glycans, existing in the ER, might regulate the entry of newly synthesized glycoproteins into the calnexin/calreticulin cycle.	Polysaccharides	48-55	calreticulin	Homo sapiens	155-167
18689872-4	2008	Carboxylated glycans are expressed on a subpopulation of RAGE on colon cancer cells and mediate S100A8/A9 binding to RAGE.	Polysaccharides	13-20	advanced glycosylation end product-specific receptor	Mus musculus	57-61
18689872-4	2008	Carboxylated glycans are expressed on a subpopulation of RAGE on colon cancer cells and mediate S100A8/A9 binding to RAGE.	Polysaccharides	13-20	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	96-102
18689872-4	2008	Carboxylated glycans are expressed on a subpopulation of RAGE on colon cancer cells and mediate S100A8/A9 binding to RAGE.	Polysaccharides	13-20	advanced glycosylation end product-specific receptor	Mus musculus	117-121
18633135-2	2008	Although dGal-1 binds to diverse glycans, it is unclear whether dGal-1 preferentially binds to specific subsets of glycans on cell surfaces to transmit signals.	Polysaccharides	33-40	Galactose-specific C-type lectin	Drosophila melanogaster	9-15
18633135-2	2008	Although dGal-1 binds to diverse glycans, it is unclear whether dGal-1 preferentially binds to specific subsets of glycans on cell surfaces to transmit signals.	Polysaccharides	115-122	Galactose-specific C-type lectin	Drosophila melanogaster	64-70
18626489-4	2008	From numerous studies over the past 15 years it is clear that glycans can influence T cell responses either by contribution to the structure of the epitope or by influencing the profile of peptide epitopes presented by APCs.	Polysaccharides	62-69	amyloid P component, serum	Homo sapiens	219-223
18621756-1	2008	BACKGROUND: The glycan cell surface molecules, stage-specific embryonic antigen (SSEA)-1, -3 and -4 and tumor-rejection antigen (TRA)-1-60 and -1-81, are expressed in specific combinations by undifferentiated pluripotent cells, i.e. embryonic stem cells, induced pluripotent stem cells, embryonal carcinoma cells, primordial germ cells and embryonic germ cells.	Polysaccharides	16-22	fucosyltransferase 4	Homo sapiens	47-99
18621756-1	2008	BACKGROUND: The glycan cell surface molecules, stage-specific embryonic antigen (SSEA)-1, -3 and -4 and tumor-rejection antigen (TRA)-1-60 and -1-81, are expressed in specific combinations by undifferentiated pluripotent cells, i.e. embryonic stem cells, induced pluripotent stem cells, embryonal carcinoma cells, primordial germ cells and embryonic germ cells.	Polysaccharides	16-22	heat shock protein 90 beta family member 1	Homo sapiens	104-135
18626489-6	2008	Here we discuss the potential impact of glycans on the profile of self-epitopes presented by APCs and the consequence of changes in glycosylation to generate neo self-epitopes resulting in the loss of tolerance and the development of autoimmune diseases.	Polysaccharides	40-47	amyloid P component, serum	Homo sapiens	93-97
18786661-7	2008	Isolated polysaccharide fractions from fungal mycelium proved to induce moderate amounts of TNF-alpha in PBMC cells in vitro.	Polysaccharides	9-23	tumor necrosis factor	Homo sapiens	92-101
18786661-8	2008	The extent of TNF-alpha induction was up to 322pgmL(-1) at a polysaccharide concentration of 200microgmL(-1) for the intracellular fraction.	Polysaccharides	61-75	tumor necrosis factor	Homo sapiens	14-23
18718934-7	2008	Furthermore, we found that the ruptured root hair phenotype of shv3 was suppressed by increasing the amount of borate, which is supposed to be involved in pectic polysaccharide cross-linking, in the medium.	Polysaccharides	162-176	PLC-like phosphodiesterase family protein	Arabidopsis thaliana	63-67
18939501-2	2008	Hib conjugate vaccines, capsule polysaccharide (polyribosylribitol phosphate: PRP) conjugated with carrier protein, are very effective and safe.	Polysaccharides	32-46	prion protein	Homo sapiens	78-81
18557833-4	2008	Biochemical characterization of cell wall polysaccharides isolated from xxt5 mutant seedlings demonstrated decreased xyloglucan quantity and reduced glucan backbone substitution with xylosyl residues.	Polysaccharides	42-57	xyloglucan xylosyltransferase 5	Arabidopsis thaliana	72-76
18811961-9	2008	By comparing sites of glycan attachment on sensitive vs. resistant strains, specific glycan sites on the head domain of the HA are implicated as important for inhibition by SP-D.	Polysaccharides	22-28	surfactant protein D	Homo sapiens	173-177
18620011-5	2008	Once loaded in the polysaccharide particles, 1-4 microm in diameter, EPO gained resistance to organic solvents and was encapsulated into PLGA microspheres without significant aggregation (&lt;2%).	Polysaccharides	19-33	erythropoietin	Mus musculus	69-72
18811961-9	2008	By comparing sites of glycan attachment on sensitive vs. resistant strains, specific glycan sites on the head domain of the HA are implicated as important for inhibition by SP-D.	Polysaccharides	85-91	surfactant protein D	Homo sapiens	173-177
18729387-13	2008	Three common structures of glycans were found in the GPI moiety of LAMP, OBCAM, and neurotrimin.	Polysaccharides	27-34	opioid binding protein/cell adhesion molecule-like	Rattus norvegicus	73-78
18811961-11	2008	CONCLUSION: Inhibition by SP-D correlates with presence of several glycan attachment sites on the HA.	Polysaccharides	67-73	surfactant protein D	Homo sapiens	26-30
18698778-4	2008	Here we examine the effects of glycosylation at C-3, C-4, and C-6 of the C-2 auxiliary-containing glycan.	Polysaccharides	98-104	complement C6	Homo sapiens	62-65
18698778-4	2008	Here we examine the effects of glycosylation at C-3, C-4, and C-6 of the C-2 auxiliary-containing glycan.	Polysaccharides	98-104	complement C2	Homo sapiens	73-76
18700760-0	2008	13C-sialic acid labeling of glycans on glycoproteins using ST6Gal-I.	Polysaccharides	28-35	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	59-67
18700760-5	2008	ST6Gal-I is itself a glycoprotein, and in this initial application, labeling of its own glycans and observation of these glycans by NMR are illustrated.	Polysaccharides	88-95	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	0-8
18700760-5	2008	ST6Gal-I is itself a glycoprotein, and in this initial application, labeling of its own glycans and observation of these glycans by NMR are illustrated.	Polysaccharides	121-128	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	Homo sapiens	0-8
18435935-5	2008	Misfolded or immature VPAC1 are taken in charge by co- and post-translational quality control that involves: 1) calnexin-dependent folding strictly through a glycan-dependent mechanism, 2) BiP-dependant folding, 3) translocation to the cytoplasm and proteasome-dependent degradation of improper proteins, and 4) post-ER quality control check points.	Polysaccharides	158-164	vasoactive intestinal peptide receptor 1	Homo sapiens	22-27
18777587-6	2008	Furthermore, a gene dosage effect was observed: anti-glycan positivity became more frequent as the number of NOD2/CARD15 SNPS increased.	Polysaccharides	53-59	nucleotide binding oligomerization domain containing 2	Homo sapiens	109-113
18777587-6	2008	Furthermore, a gene dosage effect was observed: anti-glycan positivity became more frequent as the number of NOD2/CARD15 SNPS increased.	Polysaccharides	53-59	nucleotide binding oligomerization domain containing 2	Homo sapiens	114-120
18713002-4	2008	Testis ACE (tACE) expressed in mammalian cells, mammalian cells in the presence of a glucosidase inhibitor and insect cells yielded proteins with altered catalytic and physicochemical properties, indicating that the more complex glycans confer greater thermal stabilization.	Polysaccharides	229-236	angiotensin I converting enzyme	Homo sapiens	7-10
18558097-5	2008	We propose that the preferred pathway of sulfated galactan-induced inactivation of alpha-thrombin by antithrombin starts with the polysaccharide binding to the protease through a high-affinity interaction.	Polysaccharides	130-144	coagulation factor II, thrombin	Homo sapiens	89-97
18558097-5	2008	We propose that the preferred pathway of sulfated galactan-induced inactivation of alpha-thrombin by antithrombin starts with the polysaccharide binding to the protease through a high-affinity interaction.	Polysaccharides	130-144	serpin family C member 1	Homo sapiens	101-113
18558097-7	2008	Finally, the antithrombin-alpha-thrombin covalent complex dissociates from the polysaccharide chain.	Polysaccharides	79-93	serpin family C member 1	Homo sapiens	13-25
18558097-7	2008	Finally, the antithrombin-alpha-thrombin covalent complex dissociates from the polysaccharide chain.	Polysaccharides	79-93	coagulation factor II, thrombin	Homo sapiens	17-25
19060937-2	2008	It involves the synthesis of conjugates of high-molecular capsule polysaccharides of the serogroup A meningococcus (PsA) with earlier synthesized protective fragments of membrane proteins from serogroup B meningococci.	Polysaccharides	66-81	aminopeptidase puromycin sensitive	Homo sapiens	116-119
18844683-4	2008	Using real-time PCR assays with highly specific TaqMan MGB probes that target DNA sequences within the capsular polysaccharide gene cluster, it was possible to differentiate serotypes 1, 3, 5, 4, 6A, 6B, 7F/A, 8, 9V/A/N/L, 14, 15B/C, 18C/B, 19A, 19F/B/C, 23F and 23A.	Polysaccharides	112-126	SLAM family member 7	Homo sapiens	241-244
18606225-3	2008	Fc glycans influence the binding of IgG to Fc receptors and C1q, and are therefore important for IgG effector functions.	Polysaccharides	3-10	complement C1q A chain	Homo sapiens	60-63
18558402-8	2008	The water-soluble secreted form of PPG at a concentration of 1 microg glycan/ml seems to be a potent inducer of ROS and IL-10 and to a lesser extent of IFN-gamma and IL-12.	Polysaccharides	70-76	interleukin 10	Homo sapiens	120-125
18558402-8	2008	The water-soluble secreted form of PPG at a concentration of 1 microg glycan/ml seems to be a potent inducer of ROS and IL-10 and to a lesser extent of IFN-gamma and IL-12.	Polysaccharides	70-76	interferon gamma	Homo sapiens	152-161
18642944-9	2008	Mass spectrometric analysis of glycans isolated from apolipoprotein B-100 (517 kD) showed the presence of small, specific O-linked oligosaccharides.	Polysaccharides	31-38	apolipoprotein B	Homo sapiens	53-73
18766266-10	2008	These results indicate that it is essential for thrombin to bind to the polysaccharide chain of HSPG for inducing Ca(2+) transients and NO production in BAECs.	Polysaccharides	72-86	coagulation factor II, thrombin	Bos taurus	48-56
18336801-6	2008	The genetic information for S-layer glycan biosynthesis is usually present in S-layer glycosylation (slg) gene clusters acting in concert with housekeeping genes.	Polysaccharides	36-42	sialic acid binding Ig like lectin 12	Homo sapiens	78-99
18336801-6	2008	The genetic information for S-layer glycan biosynthesis is usually present in S-layer glycosylation (slg) gene clusters acting in concert with housekeeping genes.	Polysaccharides	36-42	sialic acid binding Ig like lectin 12	Homo sapiens	101-104
18924264-8	2008	CONCLUSIONS: These results demonstrated the effects of Astragalus polysaccharides on the prevention of type 1 DM in NOD mice by correcting the imbalance between the Th1/Th2 cytokines.	Polysaccharides	66-81	negative elongation factor complex member C/D, Th1l	Mus musculus	165-168
18924264-8	2008	CONCLUSIONS: These results demonstrated the effects of Astragalus polysaccharides on the prevention of type 1 DM in NOD mice by correcting the imbalance between the Th1/Th2 cytokines.	Polysaccharides	66-81	heart and neural crest derivatives expressed 2	Mus musculus	169-172
18511294-3	2008	On-target formation of stable aniline Schiff base derivatives of glycans in DHB/An and the complete absence of such products in the mass spectra acquired in DHB/DMA matrix provide a platform for automated identification of reducing oligosaccharides in the MALDI mass spectra of complex samples.	Polysaccharides	65-72	DNA helicase B	Homo sapiens	76-79
19241585-10	2008	Moreover, oral administration of polysaccharides significantly improved TAC, LPL activity, and decreased MDA level, as well as AI.	Polysaccharides	33-48	lipoprotein lipase	Mus musculus	77-80
18713985-6	2008	MGL binding strongly correlated with the expression of the preferred MGL ligand, alpha-GalNAc-containing glycan structures, as visualized by staining with the alpha-GalNAc-specific snail lectin Helix pomatia agglutinin.	Polysaccharides	105-111	C-type lectin domain containing 10A	Homo sapiens	0-3
18713985-6	2008	MGL binding strongly correlated with the expression of the preferred MGL ligand, alpha-GalNAc-containing glycan structures, as visualized by staining with the alpha-GalNAc-specific snail lectin Helix pomatia agglutinin.	Polysaccharides	105-111	C-type lectin domain containing 10A	Homo sapiens	69-72
18691366-0	2008	Glycogen synthase 1 (GYS1) mutation in diverse breeds with polysaccharide storage myopathy.	Polysaccharides	59-73	glycogen synthase 1	Equus caballus	0-19
18691366-0	2008	Glycogen synthase 1 (GYS1) mutation in diverse breeds with polysaccharide storage myopathy.	Polysaccharides	59-73	glycogen synthase 1	Equus caballus	21-25
18691366-1	2008	BACKGROUND: A missense mutation in the GYS1 gene was recently described in horses with polysaccharide storage myopathy (PSSM).	Polysaccharides	87-101	glycogen synthase 1	Equus caballus	39-43
19241585-0	2008	Effect of polysaccharide from Auricularia auricula on blood lipid metabolism and lipoprotein lipase activity of ICR mice fed a cholesterol-enriched diet.	Polysaccharides	10-24	lipoprotein lipase	Mus musculus	81-99
19241585-1	2008	Polysaccharides from Auricularia auricula (AAP) extracted in hot water and precipitated by ethanol were chemically well defined, including 42.5% total carbohydrate, 19.6% uronic acids, 15.8% sulfate groups, 1.7% N, and 20.3% ash.	Polysaccharides	0-15	active avoidance performance	Mus musculus	43-46
18654627-5	2008	Positional cloning of pic reveals that it encodes a sulphate transporter required for sulphation of glycans (Papst1).	Polysaccharides	100-107	solute carrier family 35 member B2	Danio rerio	22-25
18490449-8	2008	Site-directed mutations at the glycan sites impaired the cell surface localization of Opalin.	Polysaccharides	31-37	oligodendrocytic myelin paranodal and inner loop protein	Mus musculus	86-92
18474667-6	2008	Each virus isolate consistently contained at least 2 or 3 glycan deletions in its gp120 envelope and showed decreased sensitivity to the CBAs and cross-resistance toward all CBAs.	Polysaccharides	58-64	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	82-87
18753065-0	2008	[Effects of Sargassum confusum polysaccharide on the expression of p53 and Rb genes in mouse sarcoma S180 cells].	Polysaccharides	31-45	transformation related protein 53, pseudogene	Mus musculus	67-70
18572208-8	2008	Chemical, chromatographic and spectroscopic methods showed that the major polysaccharide, which had 0.4 sulfate group per monomer unit and an apparent molecular mass of 160 kDa, contained a backbone of alpha-(1--&gt;3)-linked D-mannopyranosyl residues substituted at C-6, C-4 and C-2 with single stub of beta-d-xylopyranosyl residues.	Polysaccharides	74-88	complement C6	Homo sapiens	267-270
18572208-8	2008	Chemical, chromatographic and spectroscopic methods showed that the major polysaccharide, which had 0.4 sulfate group per monomer unit and an apparent molecular mass of 160 kDa, contained a backbone of alpha-(1--&gt;3)-linked D-mannopyranosyl residues substituted at C-6, C-4 and C-2 with single stub of beta-d-xylopyranosyl residues.	Polysaccharides	74-88	complement C4A (Rodgers blood group)	Homo sapiens	272-275
18572208-8	2008	Chemical, chromatographic and spectroscopic methods showed that the major polysaccharide, which had 0.4 sulfate group per monomer unit and an apparent molecular mass of 160 kDa, contained a backbone of alpha-(1--&gt;3)-linked D-mannopyranosyl residues substituted at C-6, C-4 and C-2 with single stub of beta-d-xylopyranosyl residues.	Polysaccharides	74-88	complement C2	Homo sapiens	280-283
18690643-7	2008	Among several changes in glycan expression noted, the increase of bisected N-linked glycans and the transcripts of the enzyme responsible for its biosynthesis, GnT-III, was the most significant.	Polysaccharides	25-31	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	160-167
18555566-0	2008	Adjuvant effect of water-soluble polysaccharide (PAP) from the mycelium of Polyporus albicans on the immune responses to ovalbumin in mice.	Polysaccharides	33-47	phospholipid phosphatase 1	Mus musculus	49-52
18654627-5	2008	Positional cloning of pic reveals that it encodes a sulphate transporter required for sulphation of glycans (Papst1).	Polysaccharides	100-107	solute carrier family 35 member B2	Danio rerio	109-115
18555566-0	2008	Adjuvant effect of water-soluble polysaccharide (PAP) from the mycelium of Polyporus albicans on the immune responses to ovalbumin in mice.	Polysaccharides	33-47	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	121-130
18456665-4	2008	Here we report that each Gal-8 CRD has differential glycan binding specificity and that cell signaling activity resides in the C-terminal CRD.	Polysaccharides	52-58	galectin 8	Homo sapiens	25-30
18555566-1	2008	In our previous work, a new water-soluble polysaccharide (PAP) from the mycelium of Polyporus albicans was identified for the first time.	Polysaccharides	42-56	phospholipid phosphatase 1	Mus musculus	58-61
18647407-1	2008	Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix (ECM) and basement membrane.	Polysaccharides	73-87	heparanase	Homo sapiens	0-10
18456665-11	2008	In glycan microarray analyses, each CRD of Gal-8 showed different binding, with Gal-8N recognizing sulfated and sialylated glycans and Gal-8C recognizing blood group antigens and polyLacNAc glycans.	Polysaccharides	3-9	galectin 8	Homo sapiens	43-48
18456665-11	2008	In glycan microarray analyses, each CRD of Gal-8 showed different binding, with Gal-8N recognizing sulfated and sialylated glycans and Gal-8C recognizing blood group antigens and polyLacNAc glycans.	Polysaccharides	123-130	galectin 8	Homo sapiens	43-48
18434410-1	2008	The glycan shield of the human immunodeficiency virus type 1 (HIV-1) envelope (Env) protein serves as a barrier to antibody-mediated neutralization and plays a critical role in transmission and infection.	Polysaccharides	4-10	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	79-82
18399796-10	2008	A cytosolic sialidase, Neu2, was shown to be involved in the degradation of these sialoglycans, indicating that the cytosol of mammalian cells might be equipped for metabolism of complex-type glycans.	Polysaccharides	87-94	neuraminidase 2	Homo sapiens	2-21
18399796-10	2008	A cytosolic sialidase, Neu2, was shown to be involved in the degradation of these sialoglycans, indicating that the cytosol of mammalian cells might be equipped for metabolism of complex-type glycans.	Polysaccharides	87-94	neuraminidase 2	Homo sapiens	23-27
18606649-2	2008	In adults, transmembrane activator and calcium-modulator and cyclophilin [corrected] ligand interactor (TACI) is a TNFR family member molecule with a pivotal role in Ab responses against polysaccharide vaccines.	Polysaccharides	187-201	tumor necrosis factor receptor superfamily, member 13b	Mus musculus	104-108
18606649-9	2008	These findings demonstrate that low TACI expression may be a critical factor that determines the susceptibility of newborns to infections with encapsulated bacteria and the impaired immunogenicity of polysaccharide vaccines.	Polysaccharides	200-214	tumor necrosis factor receptor superfamily, member 13b	Mus musculus	36-40
18606649-10	2008	Finally, CpG ODNs may correct deficient newborn response to polysaccharide vaccines by up-regulating TACI.	Polysaccharides	60-74	tumor necrosis factor receptor superfamily, member 13b	Mus musculus	101-105
18606678-6	2008	Remarkably, we identify a single residue in the glycan-free flank of the horse TLR4 solenoid that confers the ability to signal in response to lipid IVa.	Polysaccharides	48-54	toll like receptor 4	Equus caballus	79-83
18606687-6	2008	S. aureus capsular polysaccharide activates T cell production of IFN-gamma in a novel MHC class II-dependent mechanism.	Polysaccharides	19-33	interferon gamma	Mus musculus	65-74
18400963-7	2008	1C5 expressed Le(b) on O-linked, but not N-linked, glycans and only weakly on GLs.	Polysaccharides	51-58	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	Homo sapiens	0-3
18458070-3	2008	Biofilm formation is facilitated by the production of GbpC, an important cell surface-associated protein that binds to glucan, an adhesive polysaccharide produced by the organism itself.	Polysaccharides	139-153	glucan-binding protein	Streptococcus mutans UA159	54-58
18272537-2	2008	Well-known examples of such modification are O-linked fucose (O-fucose) and O-linked glucose (O-glucose) glycans on epidermal growth factor (EGF) domains.	Polysaccharides	105-112	epidermal growth factor	Mus musculus	116-139
18606998-6	2008	Here, we report that the extracellular domain of Klotho activates plasma-membrane resident TRPV5 through removing terminal sialic acids from their glycan chains.	Polysaccharides	147-153	klotho	Homo sapiens	49-55
18606998-6	2008	Here, we report that the extracellular domain of Klotho activates plasma-membrane resident TRPV5 through removing terminal sialic acids from their glycan chains.	Polysaccharides	147-153	transient receptor potential cation channel subfamily V member 5	Homo sapiens	91-96
18452898-1	2008	2-O-Sulfo-alpha-l-iduronic acid (IdoA2S) is one of the main components of heparin, an anticoagulant and antithrombotic polysaccharide able to potentiate the inhibitory effect of antithrombin over plasma serine proteases.	Polysaccharides	119-133	serpin family C member 1	Homo sapiens	178-190
18588555-0	2008	Evaluation by double-blind placebo-controlled oral challenge of the clinical relevance of IgE antibodies against plant glycans.	Polysaccharides	119-126	immunoglobulin heavy constant epsilon	Homo sapiens	90-93
18588555-1	2008	BACKGROUND: The clinical relevance of immunoglobulin E (IgE) to plant glycans is a longstanding debate.	Polysaccharides	70-77	immunoglobulin heavy constant epsilon	Homo sapiens	38-54
18588555-1	2008	BACKGROUND: The clinical relevance of immunoglobulin E (IgE) to plant glycans is a longstanding debate.	Polysaccharides	70-77	immunoglobulin heavy constant epsilon	Homo sapiens	56-59
18588555-6	2008	RESULTS: Twenty-four of 29 sera (82.7%) with IgE antibodies against plant glycans demonstrated IgE binding to transgenic lactoferrin.	Polysaccharides	74-81	immunoglobulin heavy constant epsilon	Homo sapiens	45-48
18588555-6	2008	RESULTS: Twenty-four of 29 sera (82.7%) with IgE antibodies against plant glycans demonstrated IgE binding to transgenic lactoferrin.	Polysaccharides	74-81	immunoglobulin heavy constant epsilon	Homo sapiens	95-98
18558481-1	2008	Galectin-1 is a 14 kDa beta-galactoside binding protein, capable of forming lattice-like structures with glycans of cellular glycoconjugates and inducing intracellular signaling.	Polysaccharides	105-112	galectin 1	Homo sapiens	0-10
18434410-8	2008	Since S. cerevisiae is genetically pliable and can be grown easily and inexpensively, it will be possible to produce new immunogens that recapitulate the 2G12 epitope and may make the glycan shield of HIV Env a practical target for vaccine development.	Polysaccharides	184-190	envelope protein	Simian immunodeficiency virus	205-208
18467454-5	2008	Glycan microarray-binding assays indicated strong affinity of His(6)-HFR1 to Manalpha1-6(Manalpha1-3)Man trisaccharide structures.	Polysaccharides	0-6	uncharacterized protein LOC542941	Triticum aestivum	69-73
18546155-4	2008	As well as the known alpha-Gal antigens, some of these glycans contained novel non-Gal carbohydrate antigens such as (Neu5Gc-Gal-GlcNAc) and Gal alpha 1-3 Lewis(x) (Gal-Gal-(Fuc)GlcNAc) which have not been reported before in N-glycans from pig organs.	Polysaccharides	55-62	galanin and GMAP prepropeptide	Homo sapiens	83-86
18546155-4	2008	As well as the known alpha-Gal antigens, some of these glycans contained novel non-Gal carbohydrate antigens such as (Neu5Gc-Gal-GlcNAc) and Gal alpha 1-3 Lewis(x) (Gal-Gal-(Fuc)GlcNAc) which have not been reported before in N-glycans from pig organs.	Polysaccharides	55-62	galanin and GMAP prepropeptide	Homo sapiens	83-86
18546155-4	2008	As well as the known alpha-Gal antigens, some of these glycans contained novel non-Gal carbohydrate antigens such as (Neu5Gc-Gal-GlcNAc) and Gal alpha 1-3 Lewis(x) (Gal-Gal-(Fuc)GlcNAc) which have not been reported before in N-glycans from pig organs.	Polysaccharides	55-62	galanin and GMAP prepropeptide	Sus scrofa	83-86
18546155-4	2008	As well as the known alpha-Gal antigens, some of these glycans contained novel non-Gal carbohydrate antigens such as (Neu5Gc-Gal-GlcNAc) and Gal alpha 1-3 Lewis(x) (Gal-Gal-(Fuc)GlcNAc) which have not been reported before in N-glycans from pig organs.	Polysaccharides	55-62	galanin and GMAP prepropeptide	Sus scrofa	83-86
18546155-7	2008	However, the results indicated that the relative quantity of alpha-Gal epitope was in the region of 50% of the complex glycans.	Polysaccharides	119-126	GLA	Sus scrofa	61-70
18668431-14	2008	One of the most interesting characteristics of P-gp/MDR1 is that its many substrates vary greatly in their structure and functionality, ranging from small molecules such as organic cations, carbohydrates, amino acids and some antibiotics to macromolecules such as polysaccharides and proteins.	Polysaccharides	264-279	phosphoglycolate phosphatase	Homo sapiens	47-51
18668431-14	2008	One of the most interesting characteristics of P-gp/MDR1 is that its many substrates vary greatly in their structure and functionality, ranging from small molecules such as organic cations, carbohydrates, amino acids and some antibiotics to macromolecules such as polysaccharides and proteins.	Polysaccharides	264-279	ATP binding cassette subfamily B member 1	Homo sapiens	52-56
18486240-5	2008	To investigate this further L-ficolin was subjected to glycan-array analysis in which L-ficolin binding to 279 different glycans was investigated.	Polysaccharides	121-128	ficolin 2	Homo sapiens	86-95
18502006-11	2008	CONCLUSIONS: Patients who were treated with the combination of methotrexate and anti-TNF demonstrated a significantly impaired immune response following pneumococcal polysaccharide vaccination as compared to patients treated with either methotrexate or anti-TNF only or immunosuppressives excluding these two compounds.	Polysaccharides	166-180	tumor necrosis factor	Homo sapiens	85-88
17937418-4	2008	Tensile testing demonstrated that a high level of flexibility of P(4HB) was retained in the P(4HB)-polysaccharide composite films, whereas the P(3HB) film and its polysaccharide composites were stiffer and more brittle.	Polysaccharides	99-113	prolyl 4-hydroxylase subunit beta	Homo sapiens	65-70
18505252-1	2008	CD22 is a B cell-specific sialic acid-binding immunoglobulin-like lectin (Siglec) whose function as a regulator of B cell signaling is modulated by its interaction with glycan ligands bearing the sequence NeuAc alpha2-6Gal.	Polysaccharides	169-175	CD22 molecule	Homo sapiens	0-4
18381078-2	2008	In this work, ADAM10 was found to contain high-mannose and complex-type glycans.	Polysaccharides	72-79	ADAM metallopeptidase domain 10	Homo sapiens	14-20
18375392-6	2008	CEA on CD44-knockdown LS174T cells exhibits higher HECA-452 immunoreactivity than CEA on wild-type cells, suggesting that CEA functions as an alternative acceptor for selectin-binding glycans.	Polysaccharides	184-191	CEA cell adhesion molecule 3	Homo sapiens	0-3
18375392-6	2008	CEA on CD44-knockdown LS174T cells exhibits higher HECA-452 immunoreactivity than CEA on wild-type cells, suggesting that CEA functions as an alternative acceptor for selectin-binding glycans.	Polysaccharides	184-191	CD44 molecule (Indian blood group)	Homo sapiens	7-11
18375392-6	2008	CEA on CD44-knockdown LS174T cells exhibits higher HECA-452 immunoreactivity than CEA on wild-type cells, suggesting that CEA functions as an alternative acceptor for selectin-binding glycans.	Polysaccharides	184-191	selectin L	Homo sapiens	167-175
18523585-0	2008	Liposomal co-entrapment of CD40mAb induces enhanced IgG responses against bacterial polysaccharide and protein.	Polysaccharides	84-98	CD40 antigen	Mus musculus	27-31
18523585-8	2008	Antibody responses against both co-entrapped protein in the form of tetanus toxoid, and Streptococcus pneumoniae capsular polysaccharide, were enhanced by co-encapsulation with CD40 antibody.	Polysaccharides	122-136	CD40 antigen	Mus musculus	177-181
18523585-10	2008	CONCLUSIONS/SIGNIFICANCE: Liposomal co-encapsulation with CD40 antibody may represent a practical means of producing more immunogenic multivalent vaccines and inducing IgG responses against polysaccharides without the need for conjugation.	Polysaccharides	190-205	CD40 antigen	Mus musculus	58-62
18518664-0	2008	Insulin sensitivity in Belgian horses with polysaccharide storage myopathy.	Polysaccharides	43-57	INS	Equus caballus	0-7
18340083-6	2008	The glycan was marginally sensitive to endoglycosidase F2 digestion but resistant to endoglycosidase F3 digestion, suggesting that the glycan on GPIHBP1 is of the oligomannose type.	Polysaccharides	4-10	GPI-anchored HDL-binding protein 1	Mus musculus	145-152
18467102-2	2008	The mucilage polysaccharide exhibits specific functions in activating murine splenocytes to produce several cytokines including IFN-gamma, IL-10, IL-6, and IL-1alpha, as well as hematopoietic growth factors GM-CSF and G-CSF.	Polysaccharides	13-27	interferon gamma	Mus musculus	128-137
18467102-2	2008	The mucilage polysaccharide exhibits specific functions in activating murine splenocytes to produce several cytokines including IFN-gamma, IL-10, IL-6, and IL-1alpha, as well as hematopoietic growth factors GM-CSF and G-CSF.	Polysaccharides	13-27	interleukin 10	Mus musculus	139-144
18467102-2	2008	The mucilage polysaccharide exhibits specific functions in activating murine splenocytes to produce several cytokines including IFN-gamma, IL-10, IL-6, and IL-1alpha, as well as hematopoietic growth factors GM-CSF and G-CSF.	Polysaccharides	13-27	interleukin 6	Mus musculus	146-150
18467102-2	2008	The mucilage polysaccharide exhibits specific functions in activating murine splenocytes to produce several cytokines including IFN-gamma, IL-10, IL-6, and IL-1alpha, as well as hematopoietic growth factors GM-CSF and G-CSF.	Polysaccharides	13-27	interleukin 1 alpha	Mus musculus	156-165
18467102-2	2008	The mucilage polysaccharide exhibits specific functions in activating murine splenocytes to produce several cytokines including IFN-gamma, IL-10, IL-6, and IL-1alpha, as well as hematopoietic growth factors GM-CSF and G-CSF.	Polysaccharides	13-27	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	207-213
18467102-2	2008	The mucilage polysaccharide exhibits specific functions in activating murine splenocytes to produce several cytokines including IFN-gamma, IL-10, IL-6, and IL-1alpha, as well as hematopoietic growth factors GM-CSF and G-CSF.	Polysaccharides	13-27	peripheral blood stem cell response to granulocyte colony stimulating factor 1	Mus musculus	218-223
18310305-2	2008	However, the structural identity of the glycan component(s) displayed by murine neutrophil PSGL-1 that contributes to its P-selectin counter-receptor activity has been uncertain, since these cells express little if any SLe(x) antigen, and because there have been no direct studies to examine murine PSGL-1 glycosylation.	Polysaccharides	40-46	selectin, platelet (p-selectin) ligand	Mus musculus	91-97
18310305-2	2008	However, the structural identity of the glycan component(s) displayed by murine neutrophil PSGL-1 that contributes to its P-selectin counter-receptor activity has been uncertain, since these cells express little if any SLe(x) antigen, and because there have been no direct studies to examine murine PSGL-1 glycosylation.	Polysaccharides	40-46	selectin, platelet	Mus musculus	122-132
18200062-2	2008	To search for binding partner(s) of ECM1, we tested the in vitro binding activity of ECM1a, a major isoform of four ECM1 splice variants, to different skin extracellular matrix proteins (such as laminin 332, collagen type IV, and fibronectin) and polysaccharides (such as hyaluronan, heparin, and chondroitin sulfate A) with solid-phase binding assay.	Polysaccharides	247-262	extracellular matrix protein 1	Homo sapiens	85-89
20408681-5	2008	Each of the three attached glycan chains on rLF contains seven to eight sugar groups.	Polysaccharides	27-33	RLF zinc finger	Rattus norvegicus	44-47
20408681-6	2008	In comparison, each of the three glycan chains attached to hLF contains 12-13 sugar groups and is twice as long.	Polysaccharides	33-39	HLF transcription factor, PAR bZIP family member	Homo sapiens	59-62
20408681-10	2008	In addition, the SE results revealed the persistently higher adsorption of rLF, again showing the effect of glycan side chains.	Polysaccharides	108-114	RLF zinc finger	Rattus norvegicus	75-78
18332077-7	2008	Interestingly, two core 1 type glycans were identified that had sialic acid alpha2-8 linked to sialylated core 1 type structures (9% of the total glycan pool).	Polysaccharides	31-38	immunoglobulin binding protein 1	Homo sapiens	76-84
18332077-7	2008	Interestingly, two core 1 type glycans were identified that had sialic acid alpha2-8 linked to sialylated core 1 type structures (9% of the total glycan pool).	Polysaccharides	31-37	immunoglobulin binding protein 1	Homo sapiens	76-84
18483624-5	2008	A highly pathogenic strain altered expression of several genes involved in glycan biosynthesis, in particular that encoding beta3 GlcNAc T5 (beta3GnT5), a GlcNAc transferase essential for the biosynthesis of Lewis antigens.	Polysaccharides	75-81	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	Homo sapiens	141-150
18340083-6	2008	The glycan was marginally sensitive to endoglycosidase F2 digestion but resistant to endoglycosidase F3 digestion, suggesting that the glycan on GPIHBP1 is of the oligomannose type.	Polysaccharides	135-141	GPI-anchored HDL-binding protein 1	Mus musculus	145-152
18385254-0	2008	Natural resistance of human immunodeficiency virus type 1 to the CD4bs antibody b12 conferred by a glycan and an arginine residue close to the CD4 binding loop.	Polysaccharides	99-105	CD4 molecule	Homo sapiens	65-68
18426228-2	2008	The primary assay for characterization and lot release of N-linked glycans on glycoprotein products at Genentech, Inc., is a capillary electrophoresis (CE) based assay, wherein PNGase F-released, APTS-labeled glycans are separated by CE with laser induced fluorescence (LIF) detection.	Polysaccharides	67-74	N-glycanase 1	Homo sapiens	177-183
18567790-5	2008	N-glycan analysis of alg3-2 and alg3-2 in the complex-glycan-less mutant background, which lacks N-acetylglucosaminyl-transferase I activity, reveals that when ALG3 activity is strongly reduced, almost all N-glycans transferred to proteins are aberrant, indicating that the Arabidopsis oligosaccharide transferase complex is remarkably substrate tolerant.	Polysaccharides	2-8	asparagine-linked glycosylation 3	Arabidopsis thaliana	21-25
18567790-5	2008	N-glycan analysis of alg3-2 and alg3-2 in the complex-glycan-less mutant background, which lacks N-acetylglucosaminyl-transferase I activity, reveals that when ALG3 activity is strongly reduced, almost all N-glycans transferred to proteins are aberrant, indicating that the Arabidopsis oligosaccharide transferase complex is remarkably substrate tolerant.	Polysaccharides	2-8	asparagine-linked glycosylation 3	Arabidopsis thaliana	32-36
18567790-5	2008	N-glycan analysis of alg3-2 and alg3-2 in the complex-glycan-less mutant background, which lacks N-acetylglucosaminyl-transferase I activity, reveals that when ALG3 activity is strongly reduced, almost all N-glycans transferred to proteins are aberrant, indicating that the Arabidopsis oligosaccharide transferase complex is remarkably substrate tolerant.	Polysaccharides	2-8	asparagine-linked glycosylation 3	Arabidopsis thaliana	160-164
18567790-6	2008	In alg3-2 plants, the aberrant glycans on glycoproteins are recognized by endogenous mannosidase I and N-acetylglucosaminyltransferase I and efficiently processed into complex-type glycans.	Polysaccharides	31-38	asparagine-linked glycosylation 3	Arabidopsis thaliana	3-7
18567790-6	2008	In alg3-2 plants, the aberrant glycans on glycoproteins are recognized by endogenous mannosidase I and N-acetylglucosaminyltransferase I and efficiently processed into complex-type glycans.	Polysaccharides	31-38	alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	Arabidopsis thaliana	85-136
18567790-6	2008	In alg3-2 plants, the aberrant glycans on glycoproteins are recognized by endogenous mannosidase I and N-acetylglucosaminyltransferase I and efficiently processed into complex-type glycans.	Polysaccharides	181-188	asparagine-linked glycosylation 3	Arabidopsis thaliana	3-7
18567790-6	2008	In alg3-2 plants, the aberrant glycans on glycoproteins are recognized by endogenous mannosidase I and N-acetylglucosaminyltransferase I and efficiently processed into complex-type glycans.	Polysaccharides	181-188	alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	Arabidopsis thaliana	85-136
18478093-9	2008	The administration of 10 microg of serogroup A polysaccharide increased the SBA-MenA GMT by 14.0-fold in the DTPW-HBV/HibMenAC-group compared to a 3.8 fold increase in the control-group.	Polysaccharides	47-61	ENAH actin regulator	Homo sapiens	80-84
18387633-9	2008	Our in vitro data suggest that reagents directed against LRP/LR or LRP mRNA such as antibodies, polysulfated glycans, or small interfering RNAs, previously shown to encompass an anti-prion activity by blocking or downregulating the prion receptor LRP/LR, might also be potential cancer therapeutics blocking metastasis by interfering with the LRP/LR-laminin interaction in neoplastic tissues.	Polysaccharides	109-116	ribosomal protein SA	Homo sapiens	57-63
18258591-4	2008	Specifically, galectin-9 and galectin-1 both kill thymocytes, peripheral T cells, and T cell lines; however, we have found that galectin-9 and galectin-1 require different glycan ligands and glycoprotein receptors to trigger T cell death.	Polysaccharides	172-178	lectin, galactose binding, soluble 9	Mus musculus	14-24
18258591-4	2008	Specifically, galectin-9 and galectin-1 both kill thymocytes, peripheral T cells, and T cell lines; however, we have found that galectin-9 and galectin-1 require different glycan ligands and glycoprotein receptors to trigger T cell death.	Polysaccharides	172-178	lectin, galactose binding, soluble 9	Mus musculus	128-138
18258591-4	2008	Specifically, galectin-9 and galectin-1 both kill thymocytes, peripheral T cells, and T cell lines; however, we have found that galectin-9 and galectin-1 require different glycan ligands and glycoprotein receptors to trigger T cell death.	Polysaccharides	172-178	lectin, galactose binding, soluble 1	Mus musculus	143-153
18387633-7	2008	The polysulfated glycans HM2602 and pentosan polysulfate (SP-54), both capable of blocking LRP/LR, reduced the invasive potential by 20% and 35%, respectively.	Polysaccharides	17-24	ribosomal protein SA	Homo sapiens	91-97
18387633-9	2008	Our in vitro data suggest that reagents directed against LRP/LR or LRP mRNA such as antibodies, polysulfated glycans, or small interfering RNAs, previously shown to encompass an anti-prion activity by blocking or downregulating the prion receptor LRP/LR, might also be potential cancer therapeutics blocking metastasis by interfering with the LRP/LR-laminin interaction in neoplastic tissues.	Polysaccharides	109-116	ribosomal protein SA	Homo sapiens	57-60
18387506-7	2008	By further modifying the polysaccharide of glycolipid as did in 4"""-dh-iGb3, we found that 4"""-dh-iGb3 elicited more Th1-biased responses than iGb3 and 4-HO-iGb3.	Polysaccharides	25-39	alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase)	Mus musculus	72-76
18166993-2	2008	Several enzyme defects have been proposed to cause CDA II based on the investigation of erythrocyte membrane glycans pinpointing to defects of early Golgi processing steps.	Polysaccharides	109-116	SEC23 homolog B, COPII coat complex component	Homo sapiens	51-57
18387506-7	2008	By further modifying the polysaccharide of glycolipid as did in 4"""-dh-iGb3, we found that 4"""-dh-iGb3 elicited more Th1-biased responses than iGb3 and 4-HO-iGb3.	Polysaccharides	25-39	alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase)	Mus musculus	100-104
18387506-7	2008	By further modifying the polysaccharide of glycolipid as did in 4"""-dh-iGb3, we found that 4"""-dh-iGb3 elicited more Th1-biased responses than iGb3 and 4-HO-iGb3.	Polysaccharides	25-39	negative elongation factor complex member C/D, Th1l	Mus musculus	119-122
18387506-7	2008	By further modifying the polysaccharide of glycolipid as did in 4"""-dh-iGb3, we found that 4"""-dh-iGb3 elicited more Th1-biased responses than iGb3 and 4-HO-iGb3.	Polysaccharides	25-39	alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase)	Mus musculus	100-104
18387506-7	2008	By further modifying the polysaccharide of glycolipid as did in 4"""-dh-iGb3, we found that 4"""-dh-iGb3 elicited more Th1-biased responses than iGb3 and 4-HO-iGb3.	Polysaccharides	25-39	alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase)	Mus musculus	100-104
18387506-9	2008	Our data suggests that a combination modification on both polysaccharide and sphingosine chain of iGb3 elicits preferential Th1-biased responses.	Polysaccharides	58-72	alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase)	Mus musculus	98-102
17981067-8	2008	Plain polysaccharide challenge induced marked increases in Hib, MenA, and MenC antibodies in primed subjects, indicative of immune memory.	Polysaccharides	6-20	ENAH actin regulator	Homo sapiens	64-68
18387506-9	2008	Our data suggests that a combination modification on both polysaccharide and sphingosine chain of iGb3 elicits preferential Th1-biased responses.	Polysaccharides	58-72	negative elongation factor complex member C/D, Th1l	Mus musculus	124-127
18545860-1	2008	A polysaccharide-rich fraction (ATF) of medicinal mushroom Agaricus brasiliensis was evaluated on the candidacidal activity, H2O2 and nitric oxide (NO) production, and expression of mannose receptors by murine peritoneal macrophages.	Polysaccharides	2-16	glial cell line derived neurotrophic factor	Mus musculus	32-35
18426978-7	2008	Therefore, GT1 acts as an ER quality control sensor by posttranslationally reglucosylating glycans on slow-folding or nonnative domains to recruit chaperones specifically to critical aberrant regions.	Polysaccharides	91-98	beta-1,4-galactosyltransferase 1	Homo sapiens	11-14
18367207-7	2008	Recognition by calnexin occurred largely in a glycan-independent manner and, at least in part, at the level of the transmembrane domain.	Polysaccharides	46-52	calnexin	Homo sapiens	15-23
18304565-5	2008	In contrast with H(2)O(2), in SFW and Gox the amount of organic compounds increased due to the accumulation of polysaccharides and proteins.	Polysaccharides	111-126	hydroxyacid oxidase 1	Homo sapiens	38-41
18272814-0	2008	Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A.	Polysaccharides	9-24	neuropilin 1	Mus musculus	51-63
18272814-0	2008	Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A.	Polysaccharides	9-24	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	121-133
18272814-3	2008	Here, we show that the sulfated polysaccharides dextran sulfate and fucoidan, but not others, reduce endothelial cell-surface levels of NRP1, NRP2, and to a lesser extent VEGFR-1 and VEGFR-2, and block the binding and in vitro function of semaphorin3A and VEGF(165).	Polysaccharides	32-47	neuropilin 1	Mus musculus	136-140
18272814-3	2008	Here, we show that the sulfated polysaccharides dextran sulfate and fucoidan, but not others, reduce endothelial cell-surface levels of NRP1, NRP2, and to a lesser extent VEGFR-1 and VEGFR-2, and block the binding and in vitro function of semaphorin3A and VEGF(165).	Polysaccharides	32-47	neuropilin 2	Mus musculus	142-146
18272814-3	2008	Here, we show that the sulfated polysaccharides dextran sulfate and fucoidan, but not others, reduce endothelial cell-surface levels of NRP1, NRP2, and to a lesser extent VEGFR-1 and VEGFR-2, and block the binding and in vitro function of semaphorin3A and VEGF(165).	Polysaccharides	32-47	FMS-like tyrosine kinase 1	Mus musculus	171-178
18272814-3	2008	Here, we show that the sulfated polysaccharides dextran sulfate and fucoidan, but not others, reduce endothelial cell-surface levels of NRP1, NRP2, and to a lesser extent VEGFR-1 and VEGFR-2, and block the binding and in vitro function of semaphorin3A and VEGF(165).	Polysaccharides	32-47	kinase insert domain protein receptor	Mus musculus	183-190
18272814-3	2008	Here, we show that the sulfated polysaccharides dextran sulfate and fucoidan, but not others, reduce endothelial cell-surface levels of NRP1, NRP2, and to a lesser extent VEGFR-1 and VEGFR-2, and block the binding and in vitro function of semaphorin3A and VEGF(165).	Polysaccharides	32-47	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	239-251
18272814-3	2008	Here, we show that the sulfated polysaccharides dextran sulfate and fucoidan, but not others, reduce endothelial cell-surface levels of NRP1, NRP2, and to a lesser extent VEGFR-1 and VEGFR-2, and block the binding and in vitro function of semaphorin3A and VEGF(165).	Polysaccharides	32-47	vascular endothelial growth factor A	Mus musculus	171-175
18252714-1	2008	The sulfated polysaccharide carrageenan (CGN) induces activation of NFkappaB and interleukin 8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by Bcl10 (B-cell CLL/lymphoma 10).	Polysaccharides	13-27	nuclear factor kappa B subunit 1	Homo sapiens	68-76
18252714-1	2008	The sulfated polysaccharide carrageenan (CGN) induces activation of NFkappaB and interleukin 8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by Bcl10 (B-cell CLL/lymphoma 10).	Polysaccharides	13-27	C-X-C motif chemokine ligand 8	Homo sapiens	81-94
18252714-1	2008	The sulfated polysaccharide carrageenan (CGN) induces activation of NFkappaB and interleukin 8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by Bcl10 (B-cell CLL/lymphoma 10).	Polysaccharides	13-27	C-X-C motif chemokine ligand 8	Homo sapiens	96-100
18252714-1	2008	The sulfated polysaccharide carrageenan (CGN) induces activation of NFkappaB and interleukin 8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by Bcl10 (B-cell CLL/lymphoma 10).	Polysaccharides	13-27	BCL10 immune signaling adaptor	Homo sapiens	185-190
18252714-1	2008	The sulfated polysaccharide carrageenan (CGN) induces activation of NFkappaB and interleukin 8 (IL-8) in human colonic epithelial cells through a pathway of innate immunity mediated by Bcl10 (B-cell CLL/lymphoma 10).	Polysaccharides	13-27	BCL10 immune signaling adaptor	Homo sapiens	192-214
18054382-6	2008	These polysaccharides showed significant activation of phenylalanine-ammonia lyase (PAL), lipooxygenase (LOX) and glutathione-S-transferase (GST) defence enzyme activities in tobacco plants.	Polysaccharides	6-21	phenylalanine ammonia-lyase	Nicotiana tabacum	55-82
32907124-5	2008	Charged polysaccharides form soluble complexes or coacervates with proteins depending on pH, ionic strength, and biopolymer charge distribution.	Polysaccharides	8-23	phenylalanine hydroxylase	Homo sapiens	89-91
18216021-0	2008	Galectin-1, -2, and -3 exhibit differential recognition of sialylated glycans and blood group antigens.	Polysaccharides	70-77	galectin 1	Homo sapiens	0-22
18216021-5	2008	Gal-2 exhibited significantly reduced binding to all sialylated glycans, whereas Gal-1 bound alpha2-3- but not alpha2-6-sialylated glycans, and Gal-3 bound to some glycans terminating in either alpha2-3- or alpha2-6-sialic acid.	Polysaccharides	64-71	galectin 2	Homo sapiens	0-5
18358097-0	2008	Purified polysaccharide from Ginkgo biloba leaves inhibits P-selectin-mediated leucocyte adhesion and inflammation.	Polysaccharides	9-23	selectin P	Homo sapiens	59-69
18236113-6	2008	Serum levels of isoforms of AFP based on differential lectin binding of the glycan moiety appear to be more sensitive and specific than total AFP level in early detection of HCC.	Polysaccharides	76-82	alpha fetoprotein	Homo sapiens	28-31
18054382-6	2008	These polysaccharides showed significant activation of phenylalanine-ammonia lyase (PAL), lipooxygenase (LOX) and glutathione-S-transferase (GST) defence enzyme activities in tobacco plants.	Polysaccharides	6-21	phenylalanine ammonia-lyase	Nicotiana tabacum	84-87
18054382-6	2008	These polysaccharides showed significant activation of phenylalanine-ammonia lyase (PAL), lipooxygenase (LOX) and glutathione-S-transferase (GST) defence enzyme activities in tobacco plants.	Polysaccharides	6-21	glutathione S-transferase	Nicotiana tabacum	114-139
18054382-6	2008	These polysaccharides showed significant activation of phenylalanine-ammonia lyase (PAL), lipooxygenase (LOX) and glutathione-S-transferase (GST) defence enzyme activities in tobacco plants.	Polysaccharides	6-21	glutathione S-transferase	Nicotiana tabacum	141-144
18223086-8	2008	Also, the CcpA-deficient strain displayed an enhanced capacity to produce acid from intracellular stores of polysaccharides, could grow faster at pH 5.5, and could acidify the environment more rapidly and to a greater extent than the parental strain.	Polysaccharides	108-123	catabolite control protein A	Streptococcus mutans UA159	10-14
18328450-0	2008	Stimulatory effect of a pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L., on G-CSF secretion from intestinal epithelial cells.	Polysaccharides	31-45	colony stimulating factor 3 (granulocyte)	Mus musculus	108-113
18212074-3	2008	Here we show that while OpR and TrR strains both produce three-dimensional biofilm structures that are indicative of rugose extracellular polysaccharide (rEPS) production, OpR strains also retain expression of CPS and are virulent in an iron-supplemented mouse model, while TrR strains lack CPS and are avirulent.	Polysaccharides	138-152	zinc finger protein of the cerebellum 5	Mus musculus	24-27
18327885-5	2008	In addition, we demonstrate the biosynthesis of bisected hybrid-type glycans with the galactose modification, with and without core fucose, on the stem cell marker glycoprotein, 19A, expressed in a partially ricin-resistant human embryonic kidney cell line.	Polysaccharides	69-76	SLAM family member 7	Homo sapiens	178-181
18330979-2	2008	While Env is typically about 50% glycan by mass, glycosylation sites are known to evolve, with some glycosylation profiles presumably being more effective at facilitating neutralization escape than others.	Polysaccharides	33-39	endogenous retrovirus group K member 20	Homo sapiens	6-9
18330979-5	2008	We have used a glycopeptide-based mass mapping approach to identify and characterize Env"s glycosylation patterns by elucidating which sites are utilized and what type of glycan motif is present at each glycosylation site.	Polysaccharides	171-177	endogenous retrovirus group K member 20	Homo sapiens	85-88
18155766-6	2008	The interaction between DC-SIGN on dendritic cells and ICAM-2 on endothelial cells is strictly glycan-specific.	Polysaccharides	95-101	intercellular adhesion molecule 2	Homo sapiens	55-61
18354232-4	2008	We used ELISA and surface plasmon resonance to show that HMGB1 binds LPS in a concentration-dependent manner and that the binding is stronger to lipid A moiety than to the polysaccharide moiety of LPS.	Polysaccharides	172-186	high mobility group box 1	Homo sapiens	57-62
18366723-1	2008	BACKGROUND: Protein-bound polysaccharide (PSK) is derived from the CM-101 strain of the fungus Coriolus versicolor and has shown anticancer activity in vitro and in in vivo experimental models and human cancers.	Polysaccharides	26-40	TAO kinase 2	Homo sapiens	42-45
18664176-3	2008	Substances developed with the specific structure of beta-galactose moieties or their analogues, including chemically modified carbohydrates, functional peptides and modified natural polysaccharide, have been evaluated as potent therapeutic ligands for galectin-3 and showed at different level their ability to interfere with carbohydrate-protein interactions and therefore, inhibit the cell-cell recognition and adhesion processes, which play an important role in tumor growth, progression and metastasis.	Polysaccharides	182-196	galectin 3	Homo sapiens	252-262
18258195-3	2008	Purified ovocleidin-17 and ansocalcin were found to bind bacterial polysaccharides, and were bactericidal against Bacillus subtilis, Staphylococcus aureus and Pseudomona aeruginosa.	Polysaccharides	67-82	ovocleidin 17	Gallus gallus	9-22
18322210-3	2008	In this study, three conserved glycans (linked to N406, N448, and N463) flanking the C4 region of gp120 that contains many known CD4 T cell epitopes were disrupted individually or in combination by asparagine-to-glutamine substitutions.	Polysaccharides	31-38	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	98-103
18322210-8	2008	These data indicate that the loss of the N448 glycan induces structural changes in the C4 region of gp120 that make this specific region more resistant to proteolytic processing, thereby restricting the generation of CD4 T cell epitopes from this region.	Polysaccharides	46-52	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	100-105
18322210-8	2008	These data indicate that the loss of the N448 glycan induces structural changes in the C4 region of gp120 that make this specific region more resistant to proteolytic processing, thereby restricting the generation of CD4 T cell epitopes from this region.	Polysaccharides	46-52	CD4 molecule	Homo sapiens	217-220
18251503-0	2008	Peroxidase-mediated oxidative cross-linking and its potential to modify mechanical properties in water-soluble polysaccharide extracts and cereal grain residues.	Polysaccharides	111-125	peroxidase-like	Triticum aestivum	0-10
18332429-5	2008	EndoS hydrolysis of the IgG glycan has profound effects on IgG effector functions, such as complement activation and Fc receptor binding, suggesting that the enzyme could be used as an immunomodulatory therapeutic agent against IgG-mediated diseases.	Polysaccharides	28-34	Fc receptor	Mus musculus	117-128
18180801-2	2008	C3d binds to the B-cell complement receptor 2 (CR2 or CD21); this binding serves as a co-activation signal to the B cell when the polysaccharide antigen portion binds simultaneously to the B-cell receptor (surface Ig).	Polysaccharides	130-144	complement receptor 2	Mus musculus	54-58
18005667-9	2008	These results suggest that the core 2 GlcNAc extended glycan chains on megalin can change the ligand-binding affinity and capacity.	Polysaccharides	54-60	low density lipoprotein receptor-related protein 2	Mus musculus	71-78
17368889-2	2008	A new water-soluble intracellular polysaccharide named as PTP, with a molecular mass of 3.7x10(4) Da, was obtained from the mycelium of Polyporus albicans (Imaz.)	Polysaccharides	34-48	protein tyrosine phosphatase, receptor type, U	Mus musculus	58-61
18206988-9	2008	Numerous CCC-specific TIMP-1 glycans were observed illustrating cancer-induced changes.	Polysaccharides	29-36	TIMP metallopeptidase inhibitor 1	Homo sapiens	22-28
18292539-2	2008	The levels of Mgat5 glycan products commonly are increased in malignancies.	Polysaccharides	20-26	mannoside acetylglucosaminyltransferase 5	Mus musculus	14-19
18292539-5	2008	The results showed that blocking expression of Mgat5-modified glycans in MA782 cells significantly suppressed tumor progression both in vivo and in vitro, strongly stimulated Th1 cytokine production, and enhanced opsonophagocytic capability of macrophages in vivo.	Polysaccharides	62-69	mannoside acetylglucosaminyltransferase 5	Mus musculus	47-52
18292539-5	2008	The results showed that blocking expression of Mgat5-modified glycans in MA782 cells significantly suppressed tumor progression both in vivo and in vitro, strongly stimulated Th1 cytokine production, and enhanced opsonophagocytic capability of macrophages in vivo.	Polysaccharides	62-69	negative elongation factor complex member C/D, Th1l	Mus musculus	175-178
18292560-0	2008	Glycosylation-dependent interactions of C-type lectin DC-SIGN with colorectal tumor-associated Lewis glycans impair the function and differentiation of monocyte-derived dendritic cells.	Polysaccharides	101-108	CD209 molecule	Homo sapiens	54-61
18292560-2	2008	DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is one of the major C-type lectins expressed on DCs and exhibits high affinity for nonsialylated Lewis (Le) glycans.	Polysaccharides	185-192	CD209 molecule	Homo sapiens	0-66
18292560-2	2008	DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is one of the major C-type lectins expressed on DCs and exhibits high affinity for nonsialylated Lewis (Le) glycans.	Polysaccharides	185-192	CD209 molecule	Homo sapiens	68-75
18292560-6	2008	DC-SIGN ligands containing Lea/Leb glycans are also highly expressed on primary cancer colon epithelia but not on normal colon epithelia, and DC-SIGN is suggested to be involved in the association between DCs and colorectal cancer cells in situ by DC-SIGN recognizing these cancer-related Le glycan ligands.	Polysaccharides	35-42	CD209 molecule	Homo sapiens	0-7
18292560-6	2008	DC-SIGN ligands containing Lea/Leb glycans are also highly expressed on primary cancer colon epithelia but not on normal colon epithelia, and DC-SIGN is suggested to be involved in the association between DCs and colorectal cancer cells in situ by DC-SIGN recognizing these cancer-related Le glycan ligands.	Polysaccharides	35-41	CD209 molecule	Homo sapiens	0-7
18287068-5	2008	The effect of these changes on glycan binding is amplified by multivalency, resulting in quantitative differences in their long alpha2-6 glycan binding affinities.	Polysaccharides	31-37	immunoglobulin binding protein 1	Homo sapiens	128-136
18344284-3	2008	The growth defect is accompanied by failure of the root cap to release border cells involved in the secretion of molecules required for efficient root interaction with the environment, and ala3 mutants are devoid of the characteristic trans-Golgi proliferation of slime vesicles containing polysaccharides and enzymes for secretion.	Polysaccharides	290-305	aminophospholipid ATPase 3	Arabidopsis thaliana	189-193
18324494-2	2008	Splenic marginal zone macrophages that express the C-type lectin receptor SIGN-R1, take up neutral polysaccharides such as dextran and the capsular polysaccharide of Streptococcus pneumoniae.	Polysaccharides	99-114	CD209b antigen	Mus musculus	74-81
18324494-2	2008	Splenic marginal zone macrophages that express the C-type lectin receptor SIGN-R1, take up neutral polysaccharides such as dextran and the capsular polysaccharide of Streptococcus pneumoniae.	Polysaccharides	99-113	CD209b antigen	Mus musculus	74-81
18324494-9	2008	These results indicate that there is a selective localization of these polysaccharides to different receptors such as SIGN-R1 for FITC dextran in marginal zone and a to-be-identified receptor selectively expressed by red pulp macrophages for GXM.	Polysaccharides	71-86	CD209b antigen	Mus musculus	118-125
18298818-0	2008	Two variants among Haemophilus influenzae serotype b strains with distinct bcs4, hcsA and hcsB genes display differences in expression of the polysaccharide capsule.	Polysaccharides	142-156	immunoglobulin mu DNA binding protein 2	Homo sapiens	81-85
18298818-0	2008	Two variants among Haemophilus influenzae serotype b strains with distinct bcs4, hcsA and hcsB genes display differences in expression of the polysaccharide capsule.	Polysaccharides	142-156	chorionic somatomammotropin hormone 2	Homo sapiens	90-94
18298818-6	2008	The two variants displayed considerable sequence divergence in the hcsA and hcsB genes, involved in transport of capsular polysaccharide to the cell surface.	Polysaccharides	122-136	immunoglobulin mu DNA binding protein 2	Homo sapiens	67-71
18227520-0	2008	The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development.	Polysaccharides	13-19	notch 1	Mus musculus	52-58
18298818-6	2008	The two variants displayed considerable sequence divergence in the hcsA and hcsB genes, involved in transport of capsular polysaccharide to the cell surface.	Polysaccharides	122-136	chorionic somatomammotropin hormone 2	Homo sapiens	76-80
17957800-0	2008	Glycan modification of the tumor antigen gp100 targets DC-SIGN to enhance dendritic cell induced antigen presentation to T cells.	Polysaccharides	0-6	premelanosome protein	Homo sapiens	41-46
17957800-5	2008	Here, we studied whether modification of the melanoma differentiation antigen gp100 with DC-SIGN-interacting glycans enhances targeting to human DC.	Polysaccharides	109-116	premelanosome protein	Homo sapiens	78-83
18250450-1	2008	Previously, we reported that a peptide, p458, from the sequence of the mammalian 60-kDa heat shock protein (hsp60) molecule can serve as a carrier in conjugate vaccines with capsular polysaccharide (CPS) molecules of various bacteria.	Polysaccharides	183-197	heat shock protein family D (Hsp60) member 1	Homo sapiens	108-113
18227520-2	2008	Here, we show that the O-fucose glycan in the Notch1 ligand-binding domain regulates the strength of Notch1 signaling during embryogenesis, postweaning growth, and T cell development in the mouse.	Polysaccharides	32-38	notch 1	Mus musculus	46-52
18227520-2	2008	Here, we show that the O-fucose glycan in the Notch1 ligand-binding domain regulates the strength of Notch1 signaling during embryogenesis, postweaning growth, and T cell development in the mouse.	Polysaccharides	32-38	notch 1	Mus musculus	101-107
18227520-8	2008	Thus, the O-fucose glycan in EGF12 of mouse Notch1 is required for optimal Notch1 signaling and T cell development in mammals.	Polysaccharides	19-25	notch 1	Mus musculus	44-50
18054351-4	2008	The polysaccharide retains the half-staggered, parallel, 3-fold, right-handed double helix stabilized by interchain hydrogen bonds from O-2H and O-6H in the Galp units.	Polysaccharides	4-18	galanin like peptide	Homo sapiens	157-161
18227520-8	2008	Thus, the O-fucose glycan in EGF12 of mouse Notch1 is required for optimal Notch1 signaling and T cell development in mammals.	Polysaccharides	19-25	notch 1	Mus musculus	75-81
18193058-0	2008	Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone.	Polysaccharides	8-14	CD44 molecule (Indian blood group)	Homo sapiens	30-34
18208314-0	2008	Towards biocompatible vaccine delivery systems: interactions of colloidal PECs based on polysaccharides with HIV-1 p24 antigen.	Polysaccharides	88-103	transmembrane p24 trafficking protein 2	Homo sapiens	115-118
18208314-1	2008	This work reports on the interactions of a model protein (p24, the capside protein of HIV-1 virus) with colloids obtained from polyelectrolyte complexes (PECs) involving two polysaccharides: chitosan and dextran sulfate (DS).	Polysaccharides	174-189	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	58-61
18309288-2	2008	GnT II, GnT IV, GnT V, and ST3Gal IV, which play important roles in the synthesis of tetraantennary-type complex glycan structures in mammalian cells, were overexpressed in Trichoplusia ni cells by using a baculovirus expression vector.	Polysaccharides	113-119	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	0-6
18212251-1	2008	PURPOSE: Heparanase is the predominant enzyme that cleaves heparan sulfate, the main polysaccharide in the extracellular matrix.	Polysaccharides	85-99	heparanase	Homo sapiens	9-19
18215164-4	2008	Normally, PMI provides the majority of mannose for glycan synthesis.	Polysaccharides	51-57	mannose phosphate isomerase	Mus musculus	10-13
18172551-3	2008	Biosynthesis of these glycans occurs in a stepwise fashion beginning with the addition of N-acetylgalactosamine by the enzyme N-acetylgalactosaminyltransferase 2 and continuing with the addition of either galactose by beta1,3-galactosyltransferase or a terminal sialic acid by a N-acetylgalactosamine-specific alpha2,6-sialyltransferase.	Polysaccharides	22-29	chondroitin polymerizing factor	Homo sapiens	126-161
18309288-2	2008	GnT II, GnT IV, GnT V, and ST3Gal IV, which play important roles in the synthesis of tetraantennary-type complex glycan structures in mammalian cells, were overexpressed in Trichoplusia ni cells by using a baculovirus expression vector.	Polysaccharides	113-119	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	16-21
18309288-2	2008	GnT II, GnT IV, GnT V, and ST3Gal IV, which play important roles in the synthesis of tetraantennary-type complex glycan structures in mammalian cells, were overexpressed in Trichoplusia ni cells by using a baculovirus expression vector.	Polysaccharides	113-119	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	27-36
18309288-5	2008	Human erythropoietin expressed in T. ni cells (rhEPO) was subjected to in vitro glycosylation by using recombinant glycosyltransferases and was converted into complex-type glycan with terminal sialic acid.	Polysaccharides	172-178	erythropoietin	Homo sapiens	6-20
18193058-8	2008	These findings establish that the HCELL glycoform of CD44 confers tropism to bone and unveil a readily translatable roadmap for programming cellular trafficking by chemical engineering of glycans on a distinct membrane glycoprotein.	Polysaccharides	188-195	CD44 molecule (Indian blood group)	Homo sapiens	53-57
18237398-9	2008	Neutralization by soluble CD4 and the neutralizing CD4 binding site (CD4BS) antibody b12 was significantly enhanced in the absence of the 386 sugar, indicating that this glycan protects the CD4BS against antibodies.	Polysaccharides	170-176	CD4 molecule	Homo sapiens	26-29
18237398-9	2008	Neutralization by soluble CD4 and the neutralizing CD4 binding site (CD4BS) antibody b12 was significantly enhanced in the absence of the 386 sugar, indicating that this glycan protects the CD4BS against antibodies.	Polysaccharides	170-176	CD4 molecule	Homo sapiens	51-54
18092758-1	2008	This study is an in-depth investigation of the interaction between polysaccharides and the proteinaceous xylanase inhibitors, Triticum aestivum xylanase inhibitor (TAXI), xylanase inhibitor protein (XIP), and thaumatin-like xylanase inhibitor (TLXI).	Polysaccharides	67-82	xylanase inhibitor protein 1	Triticum aestivum	199-202
18162264-4	2008	We conclude that both, intactness of the complement system and maturity of expression of its components, are relatively more important to aid in the immune response to polysaccharide vaccine than to conjugated vaccines.	Polysaccharides	168-182	activation induced cytidine deaminase	Homo sapiens	138-141
18183294-6	2008	Furthermore, EndoS hydrolysis of the IgG glycan influences the binding of IgG to immobilized soluble Fc gamma R and to an erythroleukemic cell line, K562, expressing Fc gamma RIIa.	Polysaccharides	41-47	Fc gamma receptor IIa	Homo sapiens	166-179
17928023-1	2008	Carbohydrate-binding agents (CBAs) have been proposed as innovative anti-HIV compounds selectively targeting the glycans of the HIV-1 envelope glycoprotein gp120 and preventing DC-SIGN-directed HIV capture by dendritic cells (DCs) and transmission to CD4(+) T-lymphocytes.	Polysaccharides	113-120	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	156-161
18205914-9	2008	RESULTS: Our results showed that the exon 2 deletion impairs synthesis of the glycan chain, known to be involved in the pro-tumoral effect of endocan.	Polysaccharides	78-84	endothelial cell specific molecule 1	Homo sapiens	142-149
18205925-10	2008	Intriguingly, there was a relationship between increasing macrophage-tropism and increased sensitivity to the CD4 binding site mab, b12, but decreased sensitivity to 2G12, a mab that binds a glycan complex on gp120.	Polysaccharides	191-197	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	209-214
17984090-0	2008	A novel mechanism for LSECtin binding to Ebola virus surface glycoprotein through truncated glycans.	Polysaccharides	92-99	C-type lectin domain family 4 member G	Homo sapiens	22-29
17984090-8	2008	Glycan analysis of the surface glycoprotein of Ebola virus reveals the presence of such truncated glycans, explaining the ability of LSECtin to facilitate infection by Ebola virus.	Polysaccharides	0-6	C-type lectin domain family 4 member G	Homo sapiens	133-140
17984090-8	2008	Glycan analysis of the surface glycoprotein of Ebola virus reveals the presence of such truncated glycans, explaining the ability of LSECtin to facilitate infection by Ebola virus.	Polysaccharides	98-105	C-type lectin domain family 4 member G	Homo sapiens	133-140
18854874-2	2008	Glycans with this type of structure are present in GpIIb/GpIIIa complex (CD41a) which is present on megakaryocytes (Mks) and platelets.	Polysaccharides	0-7	integrin subunit alpha 2b	Homo sapiens	51-56
18854874-2	2008	Glycans with this type of structure are present in GpIIb/GpIIIa complex (CD41a) which is present on megakaryocytes (Mks) and platelets.	Polysaccharides	0-7	integrin subunit beta 3	Homo sapiens	57-63
19003601-9	2008	The ability of CHI3L1 to bind both proteins and carbohydrates allows potential interactions with a variety of cell-surface and extracellular-matrix proteins, proteoglycans, and polysaccharides, and thus CHI3L1 can interface between proteomics and glycomics.	Polysaccharides	177-192	chitinase 3 like 1	Homo sapiens	15-21
18334732-6	2008	However, the binding patterns of both N- and O-linked glycan-reactive lectins indicated distinct differences in carbohydrate composition between CA125 antigen isolated from amniotic fluid and OVCAR-3 cell line.	Polysaccharides	54-60	mucin 16, cell surface associated	Homo sapiens	145-150
19126965-7	2008	In this review, we focus on the glycan changes of two serum glycoproteins, prostate specific antigen--currently used as a tumour marker of prostate cancer--and human pancreatic ribonuclease in pancreatic adenocarcinoma.	Polysaccharides	32-38	kallikrein related peptidase 3	Homo sapiens	75-100
19126966-9	2008	Glycosylated transferrin and its glycans have anti-apoptotic properties and many transferrin receptors in carcinoma could play a role in development of anaemia.	Polysaccharides	33-40	transferrin	Homo sapiens	13-24
17956937-3	2008	In the present study, the glycan profiles of free and complexed forms of PSA from cancer patient serum and of seminal plasma PSA were compared by analyzing the glycopeptides obtained by lysylendopeptidase digestion of the electrophoretically separated PSA with mass spectrometry.	Polysaccharides	26-32	kallikrein related peptidase 3	Homo sapiens	73-76
17938215-0	2008	L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway.	Polysaccharides	153-167	ficolin 2	Homo sapiens	0-9
17965434-0	2008	Characterization and protection on acute liver injury of a polysaccharide MP-I from Mytilus coruscus.	Polysaccharides	59-73	mannose phosphate isomerase	Mus musculus	74-78
17965434-1	2008	In this study, we analyzed a water-soluble polysaccharide MP-I isolated from Mytilus coruscus.	Polysaccharides	43-57	mannose phosphate isomerase	Mus musculus	58-62
17574526-1	2008	Plant lectin recognition of glycans was evaluated by SPR imaging using a model array of N-biotinylated aminoethyl glycosides of beta-D-glucose (negative control), alpha-D: -mannose (conA-responsive), beta-D-galactose (RCA(120)-responsive) and N-acetyl-beta-D-: glucosamine (WGA-responsive) printed onto neutravidin-coated gold chips.	Polysaccharides	28-35	sepiapterin reductase	Homo sapiens	53-56
17574526-4	2008	SPR imaging of an array of 40 sialylated and unsialylated glycans established the binding preference of hSiglec7 for alpha2-8-linked disialic acid structures over alpha2-6-sialyl-LacNAcs, which in turn were recognized and bound with greater affinity than alpha2-3-sialyl-LacNAcs.	Polysaccharides	58-65	sepiapterin reductase	Homo sapiens	0-3
17574526-4	2008	SPR imaging of an array of 40 sialylated and unsialylated glycans established the binding preference of hSiglec7 for alpha2-8-linked disialic acid structures over alpha2-6-sialyl-LacNAcs, which in turn were recognized and bound with greater affinity than alpha2-3-sialyl-LacNAcs.	Polysaccharides	58-65	sialic acid binding Ig like lectin 7	Homo sapiens	104-112
17574526-6	2008	The SPR imaging technique was also able to establish selective binding to the preferred glycan ligand when analyzing crude culture supernatant containing 10-20 microg of recombinant hSiglec7-Fc.	Polysaccharides	88-94	sepiapterin reductase	Homo sapiens	4-7
17574526-6	2008	The SPR imaging technique was also able to establish selective binding to the preferred glycan ligand when analyzing crude culture supernatant containing 10-20 microg of recombinant hSiglec7-Fc.	Polysaccharides	88-94	sialic acid binding Ig like lectin 7	Homo sapiens	182-190
18686103-0	2008	Bacterial polysaccharides with zwitterionic charge motifs: Toll-like receptor 2 agonists, T cell antigens, or both?	Polysaccharides	10-25	toll like receptor 2	Homo sapiens	59-79
17938215-0	2008	L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway.	Polysaccharides	153-167	mannose binding lectin 2	Homo sapiens	10-32
18686103-1	2008	Bacterial capsular polysaccharides (PS) which naturally contain zwitterionic charge motifs (ZPS) possess specific immunostimulatory activity, leading to direct activation of antigen-presenting cells (APCs) through Toll-like receptor 2 (TLR2) and of T cells in co-culture systems.	Polysaccharides	19-34	toll like receptor 2	Homo sapiens	214-234
17585952-7	2008	Due to polyanionic characteristics of Sarg, which are similar to those seen in the heparin molecule, we suggest that this polysaccharide should modulate the activity of heparin-binding vascular growth factors (such as bFGF, which also acts as a morphogen) mimetically interfering with heparan sulfate proteoglycans during microvessel formation.	Polysaccharides	122-136	fibroblast growth factor 2	Gallus gallus	218-222
18686103-1	2008	Bacterial capsular polysaccharides (PS) which naturally contain zwitterionic charge motifs (ZPS) possess specific immunostimulatory activity, leading to direct activation of antigen-presenting cells (APCs) through Toll-like receptor 2 (TLR2) and of T cells in co-culture systems.	Polysaccharides	19-34	toll like receptor 2	Homo sapiens	236-240
18686103-1	2008	Bacterial capsular polysaccharides (PS) which naturally contain zwitterionic charge motifs (ZPS) possess specific immunostimulatory activity, leading to direct activation of antigen-presenting cells (APCs) through Toll-like receptor 2 (TLR2) and of T cells in co-culture systems.	Polysaccharides	36-38	toll like receptor 2	Homo sapiens	214-234
18686103-1	2008	Bacterial capsular polysaccharides (PS) which naturally contain zwitterionic charge motifs (ZPS) possess specific immunostimulatory activity, leading to direct activation of antigen-presenting cells (APCs) through Toll-like receptor 2 (TLR2) and of T cells in co-culture systems.	Polysaccharides	36-38	toll like receptor 2	Homo sapiens	236-240
18686103-3	2008	To generate vaccine candidates with antigen and adjuvant properties in one molecule we have chemically introduced zwitterionic motifs into naturally anionic PS and find that the resulting ZPS are TLR2 agonists, able to activate human and mouse APCs.	Polysaccharides	157-159	toll like receptor 2	Homo sapiens	196-200
17947393-1	2008	The leukocyte CD33-related sialic acid-binding Ig-like lectins (Siglecs) are implicated in glycan recognition and host defense against and pathogenicity of sialylated pathogens.	Polysaccharides	91-97	CD33 molecule	Homo sapiens	14-18
18369865-1	2008	Heparins are negatively charged polydispersed linear polysaccharides which have the ability to bind a wide range of biomolecules including enzymes, serine protease inhibitors, growth factors, extracellular matrix proteins, DNA modification enzymes and hormone receptors.	Polysaccharides	53-68	complement component 1, s subcomponent 1	Mus musculus	148-163
18817066-8	2008	On the other hand, polysaccharide contents varied unpredictably with the increasing concentrations of Cd2+ and Pb2+ and extended experimental time.	Polysaccharides	19-33	CD2 molecule	Homo sapiens	102-105
18176555-2	2008	We show that a characteristic structural topology--and not the alpha2-6 linkage itself--enables specific binding of HA to alpha2-6 sialylated glycans and that recognition of this topology may be critical for adaptation of HA to bind glycans in the upper respiratory tract of humans.	Polysaccharides	142-149	immunoglobulin binding protein 1	Homo sapiens	122-130
18176555-2	2008	We show that a characteristic structural topology--and not the alpha2-6 linkage itself--enables specific binding of HA to alpha2-6 sialylated glycans and that recognition of this topology may be critical for adaptation of HA to bind glycans in the upper respiratory tract of humans.	Polysaccharides	233-240	immunoglobulin binding protein 1	Homo sapiens	122-130
18176555-1	2008	A switch in specificity of avian influenza A viruses" hemagglutinin (HA) from avian-like (alpha2-3 sialylated glycans) to human-like (alpha2-6 sialylated glycans) receptors is believed to be associated with their adaptation to infect humans.	Polysaccharides	154-161	immunoglobulin binding protein 1	Homo sapiens	134-142
18176555-3	2008	An integrated biochemical, analytical and data mining approach demonstrates that HAs from the human-adapted H1N1 and H3N2 viruses, but not H5N1 (bird flu) viruses, specifically bind to long alpha2-6 sialylated glycans with this topology.	Polysaccharides	210-217	immunoglobulin binding protein 1	Homo sapiens	190-198
18222349-2	2008	A portion of IgA1 secreted by IgA1-producing cells in patients with IgAN is galactose-deficient and consequently recognized by anti-glycan IgG or IgA1 antibodies.	Polysaccharides	132-138	immunoglobulin heavy constant alpha 1	Homo sapiens	13-17
18222349-2	2008	A portion of IgA1 secreted by IgA1-producing cells in patients with IgAN is galactose-deficient and consequently recognized by anti-glycan IgG or IgA1 antibodies.	Polysaccharides	132-138	immunoglobulin heavy constant alpha 1	Homo sapiens	30-34
18222349-2	2008	A portion of IgA1 secreted by IgA1-producing cells in patients with IgAN is galactose-deficient and consequently recognized by anti-glycan IgG or IgA1 antibodies.	Polysaccharides	132-138	IGAN1	Homo sapiens	68-72
18222349-2	2008	A portion of IgA1 secreted by IgA1-producing cells in patients with IgAN is galactose-deficient and consequently recognized by anti-glycan IgG or IgA1 antibodies.	Polysaccharides	132-138	immunoglobulin heavy constant alpha 1	Homo sapiens	30-34
17996996-5	2007	Polysaccharide challenge (PRP, PSC, PSY at 11-14 months of age) evidenced immune memory was induced for Hib, MenC/Y conjugate components.	Polysaccharides	0-14	prion protein	Homo sapiens	26-29
18056365-8	2007	Glycosylation changes during DC maturation were corroborated by mass spectrometric analysis of N- and O-glycans and by flow cytometry using plant lectins and glycan-specific Abs.	Polysaccharides	104-110	chemokine (C-C motif) ligand 22	Mus musculus	29-31
18508114-12	2008	Interestingly, plasma PAI-1 from obese subjects had a glycan composition similar to that of adipose tissue suggesting that obese subjects with elevated PAI-1 levels may have a major contribution from other tissues.	Polysaccharides	54-60	serpin family E member 1	Homo sapiens	22-27
18037196-2	2007	This study evaluates the ability of chitosan, a biocompatible polysaccharide, to (1) control the dissemination of a cytokine, GM-CSF, and (2) enhance the immunoadjuvant properties of GM-CSF.	Polysaccharides	62-76	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	126-132
18056364-0	2007	Introduction of zwitterionic motifs into bacterial polysaccharides generates TLR2 agonists able to activate APCs.	Polysaccharides	51-66	toll like receptor 2	Homo sapiens	77-81
18056364-0	2007	Introduction of zwitterionic motifs into bacterial polysaccharides generates TLR2 agonists able to activate APCs.	Polysaccharides	51-66	amyloid P component, serum	Homo sapiens	108-112
18056364-1	2007	It was shown previously that bacterial polysaccharides (PS), which naturally contain both positive and negative charges, are able to activate T cells and APCs.	Polysaccharides	39-54	amyloid P component, serum	Homo sapiens	154-158
18056364-1	2007	It was shown previously that bacterial polysaccharides (PS), which naturally contain both positive and negative charges, are able to activate T cells and APCs.	Polysaccharides	56-58	amyloid P component, serum	Homo sapiens	154-158
17918767-1	2007	A cyclic disulfide heptadecapeptide (TIP17ox; 2) derived from the lectin-like 17-amino acid domain of human tumor necrosis factor-alpha [TNF-alpha (100-116)] was synthesised and demonstrated to bind specifically to N,N-diacetylchitobiose, a disaccharide present in many glycan structures of glycoproteins.	Polysaccharides	270-276	tumor necrosis factor	Homo sapiens	108-135
17893094-7	2007	All of these effects were prevented by the addition of thiodigalactoside (TDG) or lactose, thus indicating that the proapoptotic activity of galectin-8 was due to the specific interaction of its CRDs with defined cell surface glycans.	Polysaccharides	226-233	lectin, galactose binding, soluble 8	Mus musculus	141-151
17875633-2	2007	We studied whether the specific intracellular adhesion molecule-grabbing nonintegrin R1 (Sign-R1) receptor, involved in the uptake of capsular polysaccharides (caps-PS) by antigen-presenting cells, is necessary for the antibody response to pneumococcal caps-PS and phosphorylcholine (PC).	Polysaccharides	143-158	CD209b antigen	Mus musculus	23-87
17875633-2	2007	We studied whether the specific intracellular adhesion molecule-grabbing nonintegrin R1 (Sign-R1) receptor, involved in the uptake of capsular polysaccharides (caps-PS) by antigen-presenting cells, is necessary for the antibody response to pneumococcal caps-PS and phosphorylcholine (PC).	Polysaccharides	143-158	CD209b antigen	Mus musculus	89-96
17632070-0	2007	Rapid and sensitive analysis of mucin-type glycans using an in-line flow glycan-releasing apparatus.	Polysaccharides	43-50	mucin 1, cell surface associated	Bos taurus	32-37
17632070-0	2007	Rapid and sensitive analysis of mucin-type glycans using an in-line flow glycan-releasing apparatus.	Polysaccharides	43-49	mucin 1, cell surface associated	Bos taurus	32-37
17632070-3	2007	We now report an application of the AGC to obtain mucin-type glycans with reducing end (i.e., hemiacetal group) within only 3 min.	Polysaccharides	61-68	mucin 1, cell surface associated	Bos taurus	50-55
17632070-7	2007	The advantage of the current method was also demonstrated in comparative analysis of mucin-type glycans in CGMP derived from three different animal species.	Polysaccharides	96-103	mucin 1, cell surface associated	Bos taurus	85-90
17665137-3	2007	A lectin blot analysis also indicated that recombinant COX-1 from S2COX-1/GalT-ST cells contained the glycan residues of beta1,4-linked galactose and alpha2,6-linked sialic acid.	Polysaccharides	102-108	prostaglandin-endoperoxide synthase 1	Homo sapiens	55-60
17918767-1	2007	A cyclic disulfide heptadecapeptide (TIP17ox; 2) derived from the lectin-like 17-amino acid domain of human tumor necrosis factor-alpha [TNF-alpha (100-116)] was synthesised and demonstrated to bind specifically to N,N-diacetylchitobiose, a disaccharide present in many glycan structures of glycoproteins.	Polysaccharides	270-276	tumor necrosis factor	Homo sapiens	137-146
18045109-3	2007	We review here the potential targets on the HIV Env (the glycan shield, the CD4 binding site, the coreceptor binding site, Env fusion intermediates, and the membrane proximal region) and their associated rational immunogen design strategies.	Polysaccharides	57-63	endogenous retrovirus group K member 20	Homo sapiens	48-51
17944807-4	2007	Removal of cell surface heparan sulfate by heparinases or reducing glycan sulfation by chlorate markedly decreased ECP binding to human bronchial epithelial Beas-2B cells.	Polysaccharides	67-73	ribonuclease A family member 3	Homo sapiens	115-118
18338607-6	2007	RESULT: Polysaccharide ATPS-2 from A. tabescens (25, 50, 100 mg x kg(-1)) could obviously reduce the high level of ALT, AST, NO and TNF-alpha, IL-1 on serum, inhibit the high level of MDA, increase the low activity of SOD in liver homogenate and enhance T-and B-lymphocyte proliferation, elevate the spleen, thymic index and decrease liver index of the mice to different extent.	Polysaccharides	8-22	interleukin 1 complex	Mus musculus	143-147
17996095-3	2007	In previous studies, F3, the active component of the polysaccharide extract, was found to activate various cytokines such as IL-1, IL-6, IL-12, and TNF-alpha.	Polysaccharides	53-67	interleukin 1 alpha	Homo sapiens	125-129
17996095-3	2007	In previous studies, F3, the active component of the polysaccharide extract, was found to activate various cytokines such as IL-1, IL-6, IL-12, and TNF-alpha.	Polysaccharides	53-67	tumor necrosis factor	Homo sapiens	148-157
17728258-1	2007	CD22/Siglec-2, an important inhibitory co-receptor on B-lymphocytes, is known to recognize alpha2-6-sialylated glycan as a specific ligand.	Polysaccharides	111-117	CD22 molecule	Homo sapiens	0-4
17728258-1	2007	CD22/Siglec-2, an important inhibitory co-receptor on B-lymphocytes, is known to recognize alpha2-6-sialylated glycan as a specific ligand.	Polysaccharides	111-117	CD22 molecule	Homo sapiens	5-13
17516137-6	2007	Through interfering with the cell cycle of tumor cells, PS may induce apoptosis by downregulating the expression level of cyclin D1 and upregulating the level of p21 protein.	Polysaccharides	56-58	cyclin D1	Homo sapiens	122-131
17516137-6	2007	Through interfering with the cell cycle of tumor cells, PS may induce apoptosis by downregulating the expression level of cyclin D1 and upregulating the level of p21 protein.	Polysaccharides	56-58	H3 histone pseudogene 16	Homo sapiens	162-165
18165330-7	2007	The allocation of polysaccharides between the inner and outer mucilage layers was also modified in mum2.	Polysaccharides	18-33	Glycosyl hydrolase family 35 protein	Arabidopsis thaliana	99-103
18338607-6	2007	RESULT: Polysaccharide ATPS-2 from A. tabescens (25, 50, 100 mg x kg(-1)) could obviously reduce the high level of ALT, AST, NO and TNF-alpha, IL-1 on serum, inhibit the high level of MDA, increase the low activity of SOD in liver homogenate and enhance T-and B-lymphocyte proliferation, elevate the spleen, thymic index and decrease liver index of the mice to different extent.	Polysaccharides	8-22	glutamic pyruvic transaminase, soluble	Mus musculus	115-118
18338607-6	2007	RESULT: Polysaccharide ATPS-2 from A. tabescens (25, 50, 100 mg x kg(-1)) could obviously reduce the high level of ALT, AST, NO and TNF-alpha, IL-1 on serum, inhibit the high level of MDA, increase the low activity of SOD in liver homogenate and enhance T-and B-lymphocyte proliferation, elevate the spleen, thymic index and decrease liver index of the mice to different extent.	Polysaccharides	8-22	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	120-123
18338607-6	2007	RESULT: Polysaccharide ATPS-2 from A. tabescens (25, 50, 100 mg x kg(-1)) could obviously reduce the high level of ALT, AST, NO and TNF-alpha, IL-1 on serum, inhibit the high level of MDA, increase the low activity of SOD in liver homogenate and enhance T-and B-lymphocyte proliferation, elevate the spleen, thymic index and decrease liver index of the mice to different extent.	Polysaccharides	8-22	tumor necrosis factor	Mus musculus	132-141
17658575-1	2007	HIV-1 uses glycans on gp120 to occlude its highly immunogenic epitopes.	Polysaccharides	11-18	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	22-27
17935701-1	2007	The HNK-1 carbohydrate epitope, a sulfated glucuronic acid at the non-reducing terminus of glycans, is expressed on glycoproteins and glycolipids and modulates neurite outgrowth and synaptic plasticity by affecting the adhesive and anti-adhesive properties.	Polysaccharides	91-98	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	4-9
17525829-0	2007	Inhibition of galectin-3 mediated cellular interactions by pectic polysaccharides from dietary sources.	Polysaccharides	66-81	galectin 3	Homo sapiens	14-24
17970733-6	2007	The glycan portion of immunoglobulin is critically involved in interactions with immune effectors including the Fc receptor and complement c1q; deglycosylation eliminates these interactions, while antigen (Abeta)-binding affinity is maintained.	Polysaccharides	4-10	amyloid beta (A4) precursor protein	Mus musculus	206-211
18065318-1	2007	Insulin resistance is thought to be involved in the pathogenesis of many equine conditions such as pars intermedia dysfunction, equine metabolic syndrome, diabetes mellitus, hyperlipaemia, laminitis, endotoxaemia and osteochondrosis dissecans (OCD); whereas polysaccharide storage myopathy in Quarter Horses and equine motor neuron disease (EMD) have been associated with increased insulin sensitivity.	Polysaccharides	258-272	INS	Equus caballus	0-7
17947541-4	2007	We found that transduction mediated by Env proteins of CD4-independent HIV-1 strains increased up to 5.5-fold in cells expressing unglycosylated CXCR4, suggesting that the CXCR4 glycan inhibits CD4-independent X4 virus infection.	Polysaccharides	178-184	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	39-42
18260405-1	2007	The present paper introuduces the method, with which the water-soluble polysaccharide was extracted with hot water from Garidi-15, the products were further purified with column chromatography on SephadexC-25, and the contents of water soluble polysaccharide were determined by phenyl hydrate-sulfuric acid method.	Polysaccharides	71-85	alcohol dehydrogenase iron containing 1	Homo sapiens	105-108
17947541-4	2007	We found that transduction mediated by Env proteins of CD4-independent HIV-1 strains increased up to 5.5-fold in cells expressing unglycosylated CXCR4, suggesting that the CXCR4 glycan inhibits CD4-independent X4 virus infection.	Polysaccharides	178-184	CD4 molecule	Homo sapiens	55-58
17888600-0	2007	Preventive effect of Ophiopogon japonicus polysaccharides on an autoallergic mouse model for Sjogren"s syndrome by regulating the Th1/Th2 cytokine imbalance.	Polysaccharides	42-57	negative elongation factor complex member C/D, Th1l	Mus musculus	130-133
17888600-0	2007	Preventive effect of Ophiopogon japonicus polysaccharides on an autoallergic mouse model for Sjogren"s syndrome by regulating the Th1/Th2 cytokine imbalance.	Polysaccharides	42-57	heart and neural crest derivatives expressed 2	Mus musculus	134-137
17947541-4	2007	We found that transduction mediated by Env proteins of CD4-independent HIV-1 strains increased up to 5.5-fold in cells expressing unglycosylated CXCR4, suggesting that the CXCR4 glycan inhibits CD4-independent X4 virus infection.	Polysaccharides	178-184	C-X-C motif chemokine receptor 4	Homo sapiens	145-150
18034751-0	2007	Fresh pasta quality as affected by enrichment of nonstarch polysaccharides.	Polysaccharides	59-74	solute carrier family 45 member 1	Homo sapiens	6-11
17947541-4	2007	We found that transduction mediated by Env proteins of CD4-independent HIV-1 strains increased up to 5.5-fold in cells expressing unglycosylated CXCR4, suggesting that the CXCR4 glycan inhibits CD4-independent X4 virus infection.	Polysaccharides	178-184	C-X-C motif chemokine receptor 4	Homo sapiens	172-177
17947541-4	2007	We found that transduction mediated by Env proteins of CD4-independent HIV-1 strains increased up to 5.5-fold in cells expressing unglycosylated CXCR4, suggesting that the CXCR4 glycan inhibits CD4-independent X4 virus infection.	Polysaccharides	178-184	CD4 molecule	Homo sapiens	194-197
17947541-5	2007	Co-expression of CD4 on the target cell surface or pre-incubation of virus particles with soluble CD4 abrogates the glycan-mediated inhibition of X4 virus infection, suggesting that interaction of Env protein with CD4 counteracts the inhibition.	Polysaccharides	116-122	CD4 molecule	Homo sapiens	17-20
17947541-5	2007	Co-expression of CD4 on the target cell surface or pre-incubation of virus particles with soluble CD4 abrogates the glycan-mediated inhibition of X4 virus infection, suggesting that interaction of Env protein with CD4 counteracts the inhibition.	Polysaccharides	116-122	CD4 molecule	Homo sapiens	98-101
17947541-5	2007	Co-expression of CD4 on the target cell surface or pre-incubation of virus particles with soluble CD4 abrogates the glycan-mediated inhibition of X4 virus infection, suggesting that interaction of Env protein with CD4 counteracts the inhibition.	Polysaccharides	116-122	endogenous retrovirus group W member 1, envelope	Homo sapiens	197-200
17947642-3	2007	Sialyl-Lewis(x) (sLe(x)), a glycan involved in extravasation via selectin binding, was found to be expressed exclusively on P-selectin glycoprotein ligand-1 in monocytes and immature DC.	Polysaccharides	28-34	selectin P ligand	Homo sapiens	124-156
17947541-5	2007	Co-expression of CD4 on the target cell surface or pre-incubation of virus particles with soluble CD4 abrogates the glycan-mediated inhibition of X4 virus infection, suggesting that interaction of Env protein with CD4 counteracts the inhibition.	Polysaccharides	116-122	CD4 molecule	Homo sapiens	98-101
17960575-8	2007	Disialylated diantennary glycans were observed in glycopeptides of both N-glycosylation sites of TRFE.	Polysaccharides	25-32	transferrin	Homo sapiens	97-101
17711507-1	2007	A monoclonal antibody (mAb) MY.1E12 was applied to detect MUC1 with sialylated glycans in a total of 55 formalin-fixed, paraffin-embedded surgical specimens of ovarian clear cell adenocarcinomas.	Polysaccharides	79-86	mucin 1, cell surface associated	Homo sapiens	58-62
18067226-5	2007	25 microg/ml astragalus polysaccharides and astragalosides induced TGF-beta1 expression.	Polysaccharides	24-39	transforming growth factor beta 1	Homo sapiens	67-76
18067226-7	2007	Astragalus polysaccharides at 300 microg/ml concentration exhibited an inhibition effect on TGF-beta1, HGF, MMP9 and IL-10 mRNA expression, while up-regulated MMP2 mRNA expression.	Polysaccharides	11-26	transforming growth factor beta 1	Homo sapiens	92-101
18067226-7	2007	Astragalus polysaccharides at 300 microg/ml concentration exhibited an inhibition effect on TGF-beta1, HGF, MMP9 and IL-10 mRNA expression, while up-regulated MMP2 mRNA expression.	Polysaccharides	11-26	hepatocyte growth factor	Homo sapiens	103-106
18067226-7	2007	Astragalus polysaccharides at 300 microg/ml concentration exhibited an inhibition effect on TGF-beta1, HGF, MMP9 and IL-10 mRNA expression, while up-regulated MMP2 mRNA expression.	Polysaccharides	11-26	matrix metallopeptidase 9	Homo sapiens	108-112
18067226-7	2007	Astragalus polysaccharides at 300 microg/ml concentration exhibited an inhibition effect on TGF-beta1, HGF, MMP9 and IL-10 mRNA expression, while up-regulated MMP2 mRNA expression.	Polysaccharides	11-26	interleukin 10	Homo sapiens	117-122
18067226-7	2007	Astragalus polysaccharides at 300 microg/ml concentration exhibited an inhibition effect on TGF-beta1, HGF, MMP9 and IL-10 mRNA expression, while up-regulated MMP2 mRNA expression.	Polysaccharides	11-26	matrix metallopeptidase 2	Homo sapiens	159-163
18067226-9	2007	CONCLUSION: The anti-fibrosis function of astragalus polysaccharides might be associated with up-regulation of MMP2 expression, while that of astragalosides with up-regulation of MMP2, MMP9 and IL-10 expression.	Polysaccharides	53-68	matrix metallopeptidase 2	Homo sapiens	111-115
17599380-6	2007	Molecular modeling suggested that loss of the glycan at position 386 increases exposure of the CD4 and b12 binding sites on gp120.	Polysaccharides	46-52	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	124-129
17652359-8	2007	These results implicate alpha-gustducin and Trpm5 as mediators of polysaccharide taste and Trpm5 in fat taste.	Polysaccharides	66-80	guanine nucleotide binding protein, alpha transducing 3	Mus musculus	24-39
17652359-8	2007	These results implicate alpha-gustducin and Trpm5 as mediators of polysaccharide taste and Trpm5 in fat taste.	Polysaccharides	66-80	transient receptor potential cation channel, subfamily M, member 5	Mus musculus	44-49
17611567-1	2007	Heparanase, endo-beta-D-glucuronidase, degrades heparan sulfate glycosaminoglycans - the principal polysaccharide of the basement membrane and extracellular matrix.	Polysaccharides	99-113	glucuronidase beta	Homo sapiens	17-37
17766450-8	2007	Fluorescent in situ hybridization demonstrated that populations of Bifidobacterium spp., major lactate producers, increased approximately 10-fold in incubations with polysaccharides.	Polysaccharides	166-181	histocompatibility minor 13	Homo sapiens	83-86
17621595-0	2007	The C-type lectin L-SIGN differentially recognizes glycan antigens on egg glycosphingolipids and soluble egg glycoproteins from Schistosoma mansoni.	Polysaccharides	51-57	C-type lectin domain family 4 member M	Homo sapiens	18-24
17680820-3	2007	l-ficolin, encoded by the FCN2 gene, recognizes microbial polysaccharides and glycoconjugates rich in GlcNAc or GalNAc.	Polysaccharides	58-73	ficolin 2	Homo sapiens	0-9
17680820-3	2007	l-ficolin, encoded by the FCN2 gene, recognizes microbial polysaccharides and glycoconjugates rich in GlcNAc or GalNAc.	Polysaccharides	58-73	ficolin 2	Homo sapiens	26-30
17621595-10	2007	In conclusion, our data indicate that L-SIGN recognizes both oligomannosidic N-glycans and multiply fucosylated carbohydrate motifs within Schistosoma egg antigens, which demonstrates that L-SIGN has a broad but specific glycan recognition profile.	Polysaccharides	79-85	C-type lectin domain family 4 member M	Homo sapiens	38-44
17673511-0	2007	The binding of human betacellulin to heparin, heparan sulfate and related polysaccharides.	Polysaccharides	74-89	betacellulin	Homo sapiens	21-33
17621595-10	2007	In conclusion, our data indicate that L-SIGN recognizes both oligomannosidic N-glycans and multiply fucosylated carbohydrate motifs within Schistosoma egg antigens, which demonstrates that L-SIGN has a broad but specific glycan recognition profile.	Polysaccharides	79-85	C-type lectin domain family 4 member M	Homo sapiens	189-195
17673511-9	2007	Betacellulin possesses a prominent cluster of basic residues, which is likely to constitute a binding site for sulfated polysaccharides, but the binding of nonsulfated polysaccharides may take place at a different site.	Polysaccharides	120-135	betacellulin	Homo sapiens	0-12
17927894-2	2007	This study was designed to identify and characterize the mechanism of macrophage activation by AAP, an acidic polysaccharide fraction isolated from the roots of Angelica sinensis (Oliv.)	Polysaccharides	110-124	active avoidance performance	Mus musculus	95-98
17673511-9	2007	Betacellulin possesses a prominent cluster of basic residues, which is likely to constitute a binding site for sulfated polysaccharides, but the binding of nonsulfated polysaccharides may take place at a different site.	Polysaccharides	168-183	betacellulin	Homo sapiens	0-12
18062249-12	2007	These results indicated that disruptions of MNN1 and OCH1 eliminated the hypermannosylation of the N-linked glycans, and glycoproteins were glycosylated with a single core type glycan, Man8 GlcNAc2, in the mnn1 och1 mutant.	Polysaccharides	108-114	alpha-1,3-mannosyltransferase MNN1	Saccharomyces cerevisiae S288C	44-48
18062249-12	2007	These results indicated that disruptions of MNN1 and OCH1 eliminated the hypermannosylation of the N-linked glycans, and glycoproteins were glycosylated with a single core type glycan, Man8 GlcNAc2, in the mnn1 och1 mutant.	Polysaccharides	108-114	initiation-specific alpha-1,6-mannosyltransferase	Saccharomyces cerevisiae S288C	53-57
17714731-8	2007	Thus, combination of the two endoglycosidases can provide a simple means of glycan analysis of both Fab and Fc by ESI-MS, which may contribute to the development of therapeutic IgG with customized glycan profiles.	Polysaccharides	76-82	FA complementation group B	Homo sapiens	100-103
17714731-8	2007	Thus, combination of the two endoglycosidases can provide a simple means of glycan analysis of both Fab and Fc by ESI-MS, which may contribute to the development of therapeutic IgG with customized glycan profiles.	Polysaccharides	197-203	FA complementation group B	Homo sapiens	100-103
17692467-3	2007	There are more than 150 known isoforms of Pgp, which complicates the characterization of Pgp glycans because each isoform could present a different glycome.	Polysaccharides	93-100	ATP binding cassette subfamily B member 1	Homo sapiens	42-45
17631277-6	2007	Because CD22-mediated signal regulation requires phosphorylation of CD22 by Lyn that localizes in lipid rafts and is activated by BCR, synthetic glycan ligand regulates localization of CD22 crucial for signal regulation.	Polysaccharides	145-151	CD22 molecule	Homo sapiens	8-12
17631277-6	2007	Because CD22-mediated signal regulation requires phosphorylation of CD22 by Lyn that localizes in lipid rafts and is activated by BCR, synthetic glycan ligand regulates localization of CD22 crucial for signal regulation.	Polysaccharides	145-151	CD22 molecule	Homo sapiens	68-72
17631277-6	2007	Because CD22-mediated signal regulation requires phosphorylation of CD22 by Lyn that localizes in lipid rafts and is activated by BCR, synthetic glycan ligand regulates localization of CD22 crucial for signal regulation.	Polysaccharides	145-151	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	76-79
17631277-6	2007	Because CD22-mediated signal regulation requires phosphorylation of CD22 by Lyn that localizes in lipid rafts and is activated by BCR, synthetic glycan ligand regulates localization of CD22 crucial for signal regulation.	Polysaccharides	145-151	BCR activator of RhoGEF and GTPase	Homo sapiens	130-133
17631277-6	2007	Because CD22-mediated signal regulation requires phosphorylation of CD22 by Lyn that localizes in lipid rafts and is activated by BCR, synthetic glycan ligand regulates localization of CD22 crucial for signal regulation.	Polysaccharides	145-151	CD22 molecule	Homo sapiens	68-72
17636254-8	2007	Based on these data, it is hypothesized that the genetic origin of paucimannosidic glycans in nematodes, plants, and insects involves highly divergent members of the same hexosaminidase gene family.	Polysaccharides	83-90	Beta-N-acetylhexosaminidase	Caenorhabditis elegans	171-185
17631277-0	2007	Synthetic glycan ligand excludes CD22 from antigen receptor-containing lipid rafts.	Polysaccharides	10-16	CD22 molecule	Homo sapiens	33-37
17631277-1	2007	CD22/Siglec-2 is a B cell membrane-bound lectin that recognizes glycan ligands containing alpha2,6-linked sialic acid, and negatively regulates signaling through the B cell antigen receptor (BCR).	Polysaccharides	64-70	CD22 molecule	Homo sapiens	0-4
17631277-1	2007	CD22/Siglec-2 is a B cell membrane-bound lectin that recognizes glycan ligands containing alpha2,6-linked sialic acid, and negatively regulates signaling through the B cell antigen receptor (BCR).	Polysaccharides	64-70	CD22 molecule	Homo sapiens	5-13
17631277-1	2007	CD22/Siglec-2 is a B cell membrane-bound lectin that recognizes glycan ligands containing alpha2,6-linked sialic acid, and negatively regulates signaling through the B cell antigen receptor (BCR).	Polysaccharides	64-70	BCR activator of RhoGEF and GTPase	Homo sapiens	166-195
17631277-5	2007	These results strongly suggest that synthetic glycan ligand excludes CD22 from BCR-containing lipid rafts.	Polysaccharides	46-52	CD22 molecule	Homo sapiens	69-73
17631277-5	2007	These results strongly suggest that synthetic glycan ligand excludes CD22 from BCR-containing lipid rafts.	Polysaccharides	46-52	BCR activator of RhoGEF and GTPase	Homo sapiens	79-82
17692467-5	2007	We identified distinct Pgp glycans recognized by the lectins in the digoxigenin (DIG) glycan differentiation kit from Roche Allied Science, all of which were N-glycans.	Polysaccharides	27-33	ATP binding cassette subfamily B member 1	Homo sapiens	23-26
17692467-3	2007	There are more than 150 known isoforms of Pgp, which complicates the characterization of Pgp glycans because each isoform could present a different glycome.	Polysaccharides	93-100	ATP binding cassette subfamily B member 1	Homo sapiens	89-92
17692467-5	2007	We identified distinct Pgp glycans recognized by the lectins in the digoxigenin (DIG) glycan differentiation kit from Roche Allied Science, all of which were N-glycans.	Polysaccharides	27-34	ATP binding cassette subfamily B member 1	Homo sapiens	23-26
17884631-7	2007	We discovered that polysaccharides without the iduronic acid residue displayed strong binding affinity to antithrombin and high anti-Xa and anti-IIa activities.	Polysaccharides	19-34	serpin family C member 1	Homo sapiens	106-118
17580315-7	2007	A galectin-8 mutant with an N-CRD having reduced affinity to sialylated glycans and increased affinity for other glycans, gave a Lec2 like pattern in the wt CHO cells, but a wt pattern in the Lec2 cells.	Polysaccharides	72-79	galectin-8	Cricetulus griseus	2-12
17992268-3	2007	Galectin-3 is able to oligomerize and participate in multivalent interactions with cell surface and extracellular matrix glycans, through lectin-carbohydrate interactions, thus affecting cellular functions.	Polysaccharides	121-128	lectin, galactose binding, soluble 3	Mus musculus	0-10
17580315-7	2007	A galectin-8 mutant with an N-CRD having reduced affinity to sialylated glycans and increased affinity for other glycans, gave a Lec2 like pattern in the wt CHO cells, but a wt pattern in the Lec2 cells.	Polysaccharides	113-120	galectin-8	Cricetulus griseus	2-12
17591618-8	2007	Quantitative analysis showed that CFH is mainly glycosylated by complex, diantennary disialylated, non-fucosylated glycans.	Polysaccharides	115-122	complement factor H	Homo sapiens	34-37
17766644-2	2007	Corticotrophin releasing factor (CRF) was found to be expressed by the rat placenta with the main secreted forms being phosphocholinated proCRF+/- one or two polysaccharide moieties.	Polysaccharides	158-172	corticotropin releasing hormone	Rattus norvegicus	0-31
17655983-6	2007	The pneumococcal capsular polysaccharide (CPS) used in ELISA contains several impurities; these include about 5% by weight of teicholic acid (CWPS) and the cholin binding protein, pneumococcal surface protein A (PspA) [Sorensen UB, Henrichsen J. C-polysaccharide in a pneumococcal vaccine.	Polysaccharides	26-40	surfactant protein A2	Homo sapiens	180-210
17592722-9	2007	Our study showed, for the first time, that PNGase cleaves truncated glycans as short as chitobiose from peptide.	Polysaccharides	68-75	N-glycanase 1	Homo sapiens	43-49
17655983-6	2007	The pneumococcal capsular polysaccharide (CPS) used in ELISA contains several impurities; these include about 5% by weight of teicholic acid (CWPS) and the cholin binding protein, pneumococcal surface protein A (PspA) [Sorensen UB, Henrichsen J. C-polysaccharide in a pneumococcal vaccine.	Polysaccharides	26-40	surfactant protein A2	Homo sapiens	212-216
17649979-2	2007	Agrin"s important functions include clustering acetylcholine receptors on the postsynaptic membranes of muscles and binding to the muscle protein alpha-dystroglycan through its glycan chains.	Polysaccharides	158-164	agrin	Homo sapiens	0-5
17764620-0	2007	Enhancement of antitumor effect of tegafur/uracil (UFT) plus leucovorin by combined treatment with protein-bound polysaccharide, PSK, in mouse models.	Polysaccharides	113-127	TAO kinase 2	Mus musculus	129-132
17585937-0	2007	The structures of bacteriophages K1E and K1-5 explain processive degradation of polysaccharide capsules and evolution of new host specificities.	Polysaccharides	80-94	keratin 15	Homo sapiens	33-45
17627761-10	2007	The miscoding SNPs found in the CRD regions of mouse Mbl1, Mbl2, Fcna and Fcnb may be associated with strain differences in glycan binding avidity and disposition of microbial or host ligands.	Polysaccharides	124-130	mannose-binding lectin (protein A) 1	Mus musculus	53-57
17681848-2	2007	For instance, coaxing stem cells to either proliferate or differentiate into the specific cell types needed for transplantation requires intricate glycan-dependent modulation of signalling molecules such as FGF-2, Wnt, and Notch.	Polysaccharides	147-153	fibroblast growth factor 2	Homo sapiens	207-212
17681848-3	2007	Moreover, owing to their prominent cell-surface localization and lineage-specific signatures, glycan epitopes such as the stage-specific embryonic antigens (Lewis X/SSEA-1, SSEA3-4) and tumor-rejection antigens (TRA1-60, 1-81) are ideally suited for identifying and isolating specific cell types from heterogeneous populations.	Polysaccharides	94-100	phospholipid scramblase 4	Homo sapiens	212-216
17719484-1	2007	Using FGF-2 HSGAGs as a model, de Paz and colleagues [1] have demonstrated the importance of multivalency in cooperative glycan-protein interactions to achieve specificity.	Polysaccharides	121-127	fibroblast growth factor 2	Homo sapiens	6-11
17627761-10	2007	The miscoding SNPs found in the CRD regions of mouse Mbl1, Mbl2, Fcna and Fcnb may be associated with strain differences in glycan binding avidity and disposition of microbial or host ligands.	Polysaccharides	124-130	mannose-binding lectin (protein C) 2	Mus musculus	59-63
17627761-10	2007	The miscoding SNPs found in the CRD regions of mouse Mbl1, Mbl2, Fcna and Fcnb may be associated with strain differences in glycan binding avidity and disposition of microbial or host ligands.	Polysaccharides	124-130	ficolin A	Mus musculus	65-69
17627761-10	2007	The miscoding SNPs found in the CRD regions of mouse Mbl1, Mbl2, Fcna and Fcnb may be associated with strain differences in glycan binding avidity and disposition of microbial or host ligands.	Polysaccharides	124-130	ficolin B	Mus musculus	74-78
17692138-8	2007	The MG-AGP glycan pattern was identical to plasma AGP produced by the liver.	Polysaccharides	11-17	alpha-1-acid glycoprotein	Bos taurus	7-10
17692138-9	2007	Several differences were detected, however, between plasma and SC-AGP isoforms, the most evident being the strong degree of fucosylation and the elevated number of di-antennary glycans in SC-AGP.	Polysaccharides	177-184	alpha-1-acid glycoprotein	Bos taurus	191-194
17507649-2	2007	Calnexin and the PDI homologue ERp57 work together to help fold nascent polypeptides with glycans located toward the N-terminus of a protein, whereas PDI and BiP may engage proteins that lack glycans or have sugars toward the C-terminus.	Polysaccharides	90-97	calnexin	Bos taurus	0-8
17507469-0	2007	Hepatitis C virus envelope glycoprotein E2 glycans modulate entry, CD81 binding, and neutralization.	Polysaccharides	43-50	CD81 molecule	Homo sapiens	67-71
17507469-9	2007	Only some of the glycans that affected entry and neutralization were also important for CD81 binding.	Polysaccharides	17-24	CD81 molecule	Homo sapiens	88-92
17507649-2	2007	Calnexin and the PDI homologue ERp57 work together to help fold nascent polypeptides with glycans located toward the N-terminus of a protein, whereas PDI and BiP may engage proteins that lack glycans or have sugars toward the C-terminus.	Polysaccharides	90-97	prolyl 4-hydroxylase subunit beta	Bos taurus	17-20
17522218-7	2007	Importantly, these three glycans also reduced the access of CD81 to its E2 binding site, as shown by using a soluble form of the extracellular loop of CD81 in inhibition of entry.	Polysaccharides	25-32	CD81 molecule	Homo sapiens	60-64
17522218-7	2007	Importantly, these three glycans also reduced the access of CD81 to its E2 binding site, as shown by using a soluble form of the extracellular loop of CD81 in inhibition of entry.	Polysaccharides	25-32	CD81 molecule	Homo sapiens	151-155
17496250-11	2007	IGFBP-5 was heterogeneously O-glycosylated mainly by sialylated core 1 type glycans.	Polysaccharides	76-83	insulin like growth factor binding protein 5	Homo sapiens	0-7
17496250-15	2007	The results reveal the first description of the in vivo phosphorylation of IGFBP-5 and its glycan composition.	Polysaccharides	91-97	insulin like growth factor binding protein 5	Homo sapiens	75-82
17369286-5	2007	This study demonstrated how alternations of glycans modulate the biological activity of VN.	Polysaccharides	44-51	vitronectin	Rattus norvegicus	88-90
17507649-2	2007	Calnexin and the PDI homologue ERp57 work together to help fold nascent polypeptides with glycans located toward the N-terminus of a protein, whereas PDI and BiP may engage proteins that lack glycans or have sugars toward the C-terminus.	Polysaccharides	90-97	protein disulfide isomerase family A member 3	Bos taurus	31-36
17507649-2	2007	Calnexin and the PDI homologue ERp57 work together to help fold nascent polypeptides with glycans located toward the N-terminus of a protein, whereas PDI and BiP may engage proteins that lack glycans or have sugars toward the C-terminus.	Polysaccharides	192-199	calnexin	Bos taurus	0-8
17507649-2	2007	Calnexin and the PDI homologue ERp57 work together to help fold nascent polypeptides with glycans located toward the N-terminus of a protein, whereas PDI and BiP may engage proteins that lack glycans or have sugars toward the C-terminus.	Polysaccharides	192-199	prolyl 4-hydroxylase subunit beta	Bos taurus	17-20
17507649-2	2007	Calnexin and the PDI homologue ERp57 work together to help fold nascent polypeptides with glycans located toward the N-terminus of a protein, whereas PDI and BiP may engage proteins that lack glycans or have sugars toward the C-terminus.	Polysaccharides	192-199	protein disulfide isomerase family A member 3	Bos taurus	31-36
17507649-2	2007	Calnexin and the PDI homologue ERp57 work together to help fold nascent polypeptides with glycans located toward the N-terminus of a protein, whereas PDI and BiP may engage proteins that lack glycans or have sugars toward the C-terminus.	Polysaccharides	192-199	prolyl 4-hydroxylase subunit beta	Bos taurus	150-153
17589510-3	2007	Although TH1- and TH-17-differentiated cells expressed the repertoire of cell surface glycans critical for galectin-1-induced cell death, TH2 cells were protected from galectin-1 through differential sialylation of cell surface glycoproteins.	Polysaccharides	86-93	lectin, galactose binding, soluble 1	Mus musculus	107-117
17623275-0	2007	Interpretation support for multistage MS: a mathematical method for theoretical generation of glycan fragments and calculation of their masses.	Polysaccharides	94-100	moesin	Homo sapiens	38-40
17623275-6	2007	This method is applicable to glycan analytical techniques using MS, MS/MS, and multistage MS (MSn) with different ionization methods, derivatives, or ions used.	Polysaccharides	29-35	moesin	Homo sapiens	64-66
17623275-6	2007	This method is applicable to glycan analytical techniques using MS, MS/MS, and multistage MS (MSn) with different ionization methods, derivatives, or ions used.	Polysaccharides	29-35	moesin	Homo sapiens	68-70
17623275-6	2007	This method is applicable to glycan analytical techniques using MS, MS/MS, and multistage MS (MSn) with different ionization methods, derivatives, or ions used.	Polysaccharides	29-35	moesin	Homo sapiens	68-70
17623275-6	2007	This method is applicable to glycan analytical techniques using MS, MS/MS, and multistage MS (MSn) with different ionization methods, derivatives, or ions used.	Polysaccharides	29-35	moesin	Homo sapiens	68-70
17623275-6	2007	This method is applicable to glycan analytical techniques using MS, MS/MS, and multistage MS (MSn) with different ionization methods, derivatives, or ions used.	Polysaccharides	29-35	moesin	Homo sapiens	94-97
17395585-10	2007	Additionally, we show that calnexin interacts with the receptors via two distinct mechanisms, glycan-dependent and glycan-independent, which may underlie the multiple effects (ER retention and surface trafficking) of calnexin on receptor expression.	Polysaccharides	94-100	calnexin	Homo sapiens	27-35
17395585-10	2007	Additionally, we show that calnexin interacts with the receptors via two distinct mechanisms, glycan-dependent and glycan-independent, which may underlie the multiple effects (ER retention and surface trafficking) of calnexin on receptor expression.	Polysaccharides	94-100	calnexin	Homo sapiens	217-225
17395585-10	2007	Additionally, we show that calnexin interacts with the receptors via two distinct mechanisms, glycan-dependent and glycan-independent, which may underlie the multiple effects (ER retention and surface trafficking) of calnexin on receptor expression.	Polysaccharides	115-121	calnexin	Homo sapiens	27-35
17369286-13	2007	The results demonstrate that glycan alterations during tissue remodeling induce increased multimerization state to enhance the biological activity of VN.	Polysaccharides	29-35	vitronectin	Rattus norvegicus	150-152
17582096-5	2007	Compositional and structural studies of the carbohydrates of bovine milk MUC15 showed that the glycans are composed of fucose, galactose, mannose, N-acetylgalactosamine, N-acetylglycosamine, and sialic acid.	Polysaccharides	95-102	mucin 15, cell surface associated	Bos taurus	73-78
17606977-5	2007	We found that purified polysaccharides from GL mycelium could induce human PBMC proliferation and phenotypic and functional maturation of DCs with significant IL-12 and IL-10 production.	Polysaccharides	23-38	interleukin 10	Homo sapiens	169-174
17606977-7	2007	In general, all these polysaccharides did not polarize T cells into either T(h)1 or T(h)2 or regulatory T cells, except for crude spore polysaccharides-treated DCs which could suppress T cell proliferation with IL-10 production.	Polysaccharides	136-151	interleukin 10	Homo sapiens	211-216
17499190-8	2007	U. rigida polysaccharides also stimulated macrophage secretion of PGE(2) and induced an increase in COX-2 and NOS-2 expression.	Polysaccharides	10-25	prostaglandin-endoperoxide synthase 2	Mus musculus	100-105
17499190-8	2007	U. rigida polysaccharides also stimulated macrophage secretion of PGE(2) and induced an increase in COX-2 and NOS-2 expression.	Polysaccharides	10-25	nitric oxide synthase 2, inducible	Mus musculus	110-115
17582096-7	2007	The glycan structures of MUC15 were further studied by enzymatic deglycosylation experiments using different endo- and exoglycosidases as well as a panel of lectins.	Polysaccharides	4-10	mucin 15, cell surface associated	Bos taurus	25-30
17333254-9	2007	A model for the regulation of the RGP activity and its binding to golgi membranes based on the glycosylation of the protein is proposed where the sugars linked to oligomeric form of RGP in the golgi may be transferred to acceptors involved in polysaccharide biosynthesis.	Polysaccharides	243-257	reversibly glycosylated polypeptide 3	Arabidopsis thaliana	34-37
17333254-9	2007	A model for the regulation of the RGP activity and its binding to golgi membranes based on the glycosylation of the protein is proposed where the sugars linked to oligomeric form of RGP in the golgi may be transferred to acceptors involved in polysaccharide biosynthesis.	Polysaccharides	243-257	reversibly glycosylated polypeptide 3	Arabidopsis thaliana	182-185
17420244-0	2007	Scavenger receptor C-type lectin binds to the leukocyte cell surface glycan Lewis(x) by a novel mechanism.	Polysaccharides	69-75	collectin sub-family member 12	Mus musculus	0-32
17459879-4	2007	Incubation of murine bone marrow-derived macrophages and human dendritic cells showed that the acylated polysaccharide fractions were potent inducers of tumor necrosis factor-alpha, interleukin-12, and interleukin-10 compared with nonacylated AMs, which led to only a marginal cytokine release.	Polysaccharides	104-118	tumor necrosis factor	Homo sapiens	153-180
17459879-4	2007	Incubation of murine bone marrow-derived macrophages and human dendritic cells showed that the acylated polysaccharide fractions were potent inducers of tumor necrosis factor-alpha, interleukin-12, and interleukin-10 compared with nonacylated AMs, which led to only a marginal cytokine release.	Polysaccharides	104-118	interleukin 10	Homo sapiens	202-216
17420244-1	2007	The scavenger receptor C-type lectin (SRCL) is unique in the family of class A scavenger receptors, because in addition to binding sites for oxidized lipoproteins it also contains a C-type carbohydrate-recognition domain (CRD) that interacts with specific glycans.	Polysaccharides	256-263	collectin sub-family member 12	Mus musculus	4-36
17420244-1	2007	The scavenger receptor C-type lectin (SRCL) is unique in the family of class A scavenger receptors, because in addition to binding sites for oxidized lipoproteins it also contains a C-type carbohydrate-recognition domain (CRD) that interacts with specific glycans.	Polysaccharides	256-263	collectin sub-family member 12	Mus musculus	38-42
17420244-4	2007	The interaction between mouse SRCL and Lewis(x) is analogous to the way that selectins and DC-SIGN bind to related fucosylated glycans, but the mechanism of the interaction is novel, because it is based on a primary galactose-binding site similar to the binding site in the asialoglycoprotein receptor.	Polysaccharides	127-134	collectin sub-family member 12	Mus musculus	30-34
17499031-1	2007	Calreticulin is a molecular chaperone with specificity for polypeptides and N-linked monoglucosylated glycans.	Polysaccharides	102-109	calreticulin	Homo sapiens	0-12
17303715-1	2007	Mucin glycan is the primary determinant of mucin functions.	Polysaccharides	6-12	LOC100508689	Homo sapiens	0-5
17303715-1	2007	Mucin glycan is the primary determinant of mucin functions.	Polysaccharides	6-12	LOC100508689	Homo sapiens	43-48
17493577-5	2007	Mass spectrometric analysis of cellular N-linked glycans revealed that depletion of VCP decreases the level of high-mannose glycoproteins, increases the levels of truncated low-mannose glycoproteins and induces changes in the abundance of complex glycans assembled in post-ER compartments.	Polysaccharides	49-56	valosin containing protein	Homo sapiens	84-87
17293352-10	2007	For the complex-type glycans (partially) (alpha2-6)-sialylated (nearly only N-acetylneuraminic acid) diantennary structures were found; part of the structures were (alpha1-6)-core-fucosylated or (alpha1-3)-fucosylated in the upper antenna (Lewis x).	Polysaccharides	21-28	immunoglobulin binding protein 1	Homo sapiens	42-50
17587672-2	2007	CPE, crude polysaccharide extract isolated from the rhizome of C. xanthorrhiza using 0.1 N NaOH, consisted of arabinose (18.69%), galactose (14.0%), glucose (50.67%), mannose (12.97%), rhamnose (2.73%), and xylose (0.94%), with an average molecular weight of 33,000 Da.	Polysaccharides	11-25	carboxypeptidase E	Mus musculus	0-3
17293352-10	2007	For the complex-type glycans (partially) (alpha2-6)-sialylated (nearly only N-acetylneuraminic acid) diantennary structures were found; part of the structures were (alpha1-6)-core-fucosylated or (alpha1-3)-fucosylated in the upper antenna (Lewis x).	Polysaccharides	21-28	adrenoceptor alpha 1D	Homo sapiens	165-173
17293352-10	2007	For the complex-type glycans (partially) (alpha2-6)-sialylated (nearly only N-acetylneuraminic acid) diantennary structures were found; part of the structures were (alpha1-6)-core-fucosylated or (alpha1-3)-fucosylated in the upper antenna (Lewis x).	Polysaccharides	21-28	adrenoceptor alpha 1D	Homo sapiens	196-204
17513880-7	2007	Using a glycan array screen, we identified the novel capacity of the TIM-3 Ig domain to recognize specific carbohydrate moieties, suggesting a role for carbohydrate modification along with protein epitopes in TIM ligand recognition.	Polysaccharides	8-14	translocation induced circling mutation	Mus musculus	69-72
17466910-4	2007	Dose-response analyses in mice then showed that a sample of the human IgG1 version of 2C11 Ab in which 40% of the Fc glycans in the population of Ab molecules were fucosylated was 3-5 times more potent than a sample with 90% of its Fc glycans fucosylated.	Polysaccharides	117-124	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	70-74
17513880-7	2007	Using a glycan array screen, we identified the novel capacity of the TIM-3 Ig domain to recognize specific carbohydrate moieties, suggesting a role for carbohydrate modification along with protein epitopes in TIM ligand recognition.	Polysaccharides	8-14	translocation induced circling mutation	Mus musculus	209-212
17466910-4	2007	Dose-response analyses in mice then showed that a sample of the human IgG1 version of 2C11 Ab in which 40% of the Fc glycans in the population of Ab molecules were fucosylated was 3-5 times more potent than a sample with 90% of its Fc glycans fucosylated.	Polysaccharides	235-242	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	70-74
17802888-13	2007	CONCLUSION: Effects of stigma maydis polysaccharide on gastrointestinal movement are probably related to the increasing of CCK level in plasm.	Polysaccharides	37-51	cholecystokinin	Rattus norvegicus	123-126
17409160-10	2007	The most likely epitope recognized by the monomeric gp120 binding neutralizing fraction is the CD4 binding site, although other epitopes, such as the glycan shield, cannot be excluded.	Polysaccharides	150-156	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	52-57
17440690-4	2007	The results obtained show significant variations on the expression/distribution of membrane surface glycans as detected by both WGA and SNA, two lectins that recognize primarily cellular internal membrane glycolipids.	Polysaccharides	100-107	snail family transcriptional repressor 1	Homo sapiens	136-139
17537973-3	2007	TNR is a major extracellular matrix glycoprotein of the CNS and carries the HNK-1 carbohydrate (human natural killer cell glycan), which has been identified as the functional epitope mediating regulation of GABAergic transmission via GABA(B) receptors.	Polysaccharides	122-128	tenascin R	Homo sapiens	0-3
17537973-3	2007	TNR is a major extracellular matrix glycoprotein of the CNS and carries the HNK-1 carbohydrate (human natural killer cell glycan), which has been identified as the functional epitope mediating regulation of GABAergic transmission via GABA(B) receptors.	Polysaccharides	122-128	beta-1,3-glucuronyltransferase 1	Homo sapiens	76-81
17496541-1	2007	BACKGROUND: Fucoidan, a new low molecular weight sulfated polysaccharide (LMWF), has previously been shown to mobilize bone marrow-derived progenitors cells via stimulation of stromal derived factor (SDF)-1 release.	Polysaccharides	58-72	C-X-C motif chemokine ligand 12	Rattus norvegicus	176-206
17466984-3	2007	The discovery of "Man(6)-based" hybrid-type glycans reveals a broader in vivo specificity of N-acetylglucosaminyltransferase I, further defines the arm-specific tolerance of core alpha1-6 fucosyltransferase to terminal alpha1-2 mannose residues, and suggests that disruption of Golgi alpha-mannosidase II activity is capable of inducing potentially "non-self" structures.	Polysaccharides	44-51	adrenoceptor alpha 1D	Homo sapiens	219-227
17466984-3	2007	The discovery of "Man(6)-based" hybrid-type glycans reveals a broader in vivo specificity of N-acetylglucosaminyltransferase I, further defines the arm-specific tolerance of core alpha1-6 fucosyltransferase to terminal alpha1-2 mannose residues, and suggests that disruption of Golgi alpha-mannosidase II activity is capable of inducing potentially "non-self" structures.	Polysaccharides	44-51	mannosidase alpha class 2A member 1	Homo sapiens	278-304
17485663-2	2007	This glycan is essential for maintaining a functional Fc structure, which is a prerequisite for antibody-mediated effector functions, such as the interaction with cellular Fc receptors or the complement component C1q.	Polysaccharides	5-11	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	213-216
17458940-4	2007	Here we apply a quartz crystal microbalance (QCM) biosensor to determine the kinetic constants of heparin and other sulfated polysaccharides binding to immobilized P-selectin.	Polysaccharides	125-140	selectin P	Homo sapiens	164-174
17502612-8	2007	We demonstrate that entry of FVIII into human dendritic cells (DC) leading to T cell activation, is mediated by mannose-terminating glycans on FVIII.	Polysaccharides	132-139	coagulation factor VIII	Homo sapiens	29-34
17502612-8	2007	We demonstrate that entry of FVIII into human dendritic cells (DC) leading to T cell activation, is mediated by mannose-terminating glycans on FVIII.	Polysaccharides	132-139	coagulation factor VIII	Homo sapiens	143-148
17502612-10	2007	Saturation of mannose receptors on DC with mannan, and enzymatic removal of mannosylated glycans from FVIII lead to reduced T cell activation.	Polysaccharides	89-96	coagulation factor VIII	Homo sapiens	102-107
17397137-7	2007	Derivatization remains critical to position substructures in a glycan array since product ions carry fragmentation "scars" throughout the MSn tree.	Polysaccharides	63-69	moesin	Homo sapiens	138-141
17411071-9	2007	The new technique was further evaluated with glycan profiling of serum transferrin and proved to be a sensitive method for the characterizing protein glycosylation.	Polysaccharides	45-51	transferrin	Homo sapiens	71-82
17384412-6	2007	The sulfate groups of heparan sulfate- and chondroitin sulfate-containing proteoglycans are the PMN binding sites for HLE and CG since binding of HLE and CG to PMN was inhibited by incubating PMN with 1) trypsin, chondroitinase ABC, and heparitinases, but not other glycanases, and 2) purified chondroitin sulfates, heparan sulfate, and other sulfated molecules, but not with non-sulfated glycans.	Polysaccharides	80-87	cathepsin G	Homo sapiens	126-128
17384412-6	2007	The sulfate groups of heparan sulfate- and chondroitin sulfate-containing proteoglycans are the PMN binding sites for HLE and CG since binding of HLE and CG to PMN was inhibited by incubating PMN with 1) trypsin, chondroitinase ABC, and heparitinases, but not other glycanases, and 2) purified chondroitin sulfates, heparan sulfate, and other sulfated molecules, but not with non-sulfated glycans.	Polysaccharides	80-87	cathepsin G	Homo sapiens	154-156
17204386-2	2007	In the present study, we purified the polysaccharides, termed SHP, from SHE preparation and examined their immunomodulatory activity alone and in combination with interferon (IFN)-gamma.	Polysaccharides	38-53	nuclear receptor subfamily 0, group B, member 2	Mus musculus	62-65
17490484-4	2007	RESULTS: Viruses that agglutinate, or do not agglutinate, chicken red cells show identical binding to a Glycan Array of 264 oligosaccharides, binding exclusively to a subset of alpha2-6-sialylsaccharides.	Polysaccharides	104-110	immunoglobulin binding protein 1	Homo sapiens	177-185
17439157-6	2007	Interestingly, despite recent reports of relaxed selectivity toward the glycan donor, PglB was not found to be capable of utilizing glycosyl donors such as dolichyl-pyrophosphate-chitobiose, which is the minimum substrate for the eukaryotic OT process.	Polysaccharides	72-78	epiphycan	Homo sapiens	86-90
17204386-8	2007	These results confirm that Salicornia herbacea contains immunomodulatory polysaccharides that activate monocytes synergistically with small doses of IFN-gamma.	Polysaccharides	73-88	interferon gamma	Mus musculus	149-158
17251309-11	2007	The display of alternative carbohydrate structures on GCase expressed in these systems also runs the risk of undesirable consequences, such as an increase in MBL binding or a possible increase in immunogenicity due to the presentation of non-mammalian glycans.	Polysaccharides	252-259	glucosidase, beta, acid	Mus musculus	54-59
17250593-0	2007	Neisseria meningitidis type C capsular polysaccharide inhibits lipooligosaccharide-induced cell activation by binding to CD14.	Polysaccharides	39-53	CD14 molecule	Homo sapiens	121-125
17393152-1	2007	Enzymatically cleaved glycans from sub-milligram quantities of erythropoietin (EPO) and ovalbumin have been analyzed, without further purification, by two-dimensional diffusion-ordered nuclear magnetic resonance spectroscopy.	Polysaccharides	22-29	erythropoietin	Homo sapiens	63-77
17393152-1	2007	Enzymatically cleaved glycans from sub-milligram quantities of erythropoietin (EPO) and ovalbumin have been analyzed, without further purification, by two-dimensional diffusion-ordered nuclear magnetic resonance spectroscopy.	Polysaccharides	22-29	erythropoietin	Homo sapiens	79-82
17461929-12	2007	The rate of thrombin generation during the propagation phase, rather than the endogenous thrombin potential, is more sensitive to the anticoagulant activity of fondaparinux and the polysaccharide chains of LMWHs possessing only anti-FXa activity.	Polysaccharides	181-195	coagulation factor II, thrombin	Homo sapiens	12-20
17296751-3	2007	We report that inactivation of the wbtA-encoded dehydratase of the O-antigen polysaccharide (O-PS) locus of the still-unlicensed live vaccine strain of F. tularensis (LVS) results in a mutant (the LVS wbtA mutant) with remarkably attenuated virulence.	Polysaccharides	77-91	lacking vigorous sperm	Mus musculus	167-170
17296751-3	2007	We report that inactivation of the wbtA-encoded dehydratase of the O-antigen polysaccharide (O-PS) locus of the still-unlicensed live vaccine strain of F. tularensis (LVS) results in a mutant (the LVS wbtA mutant) with remarkably attenuated virulence.	Polysaccharides	77-91	lacking vigorous sperm	Mus musculus	197-200
17313488-0	2007	Impact of T-cell receptor Vbeta haplotypes on the development of dermatitis in DS-Nh mice: synergistic production of interleukin-13 caused by staphylococcal enterotoxin C and peptide glycans from Staphylococcus aureus.	Polysaccharides	183-190	interleukin 13	Mus musculus	117-131
17307800-0	2007	TLR2-dependent recognition of Streptococcus suis is modulated by the presence of capsular polysaccharide which modifies macrophage responsiveness.	Polysaccharides	90-104	toll-like receptor 2	Mus musculus	0-4
17417647-5	2007	By profiling both protein and glycan variation in multiple samples using parallel sandwich and glycan-detection assays, we found cancer-associated glycan alteration on the proteins MUC1 and CEA in the serum of pancreatic cancer patients.	Polysaccharides	30-36	mucin 1, cell surface associated	Homo sapiens	181-185
17417647-5	2007	By profiling both protein and glycan variation in multiple samples using parallel sandwich and glycan-detection assays, we found cancer-associated glycan alteration on the proteins MUC1 and CEA in the serum of pancreatic cancer patients.	Polysaccharides	95-101	mucin 1, cell surface associated	Homo sapiens	181-185
17417647-5	2007	By profiling both protein and glycan variation in multiple samples using parallel sandwich and glycan-detection assays, we found cancer-associated glycan alteration on the proteins MUC1 and CEA in the serum of pancreatic cancer patients.	Polysaccharides	95-101	mucin 1, cell surface associated	Homo sapiens	181-185
17409189-2	2007	Here we reveal that a soluble fragment of lysine-type peptidoglycan, a long glycan chain with short stem peptides, is a potent activator of the Drosophila Toll pathway and the prophenoloxidase activation cascade in the beetle Tenebrio molitor.	Polysaccharides	61-67	Toll	Drosophila melanogaster	155-159
17409189-2	2007	Here we reveal that a soluble fragment of lysine-type peptidoglycan, a long glycan chain with short stem peptides, is a potent activator of the Drosophila Toll pathway and the prophenoloxidase activation cascade in the beetle Tenebrio molitor.	Polysaccharides	61-67	Prophenoloxidase 1	Drosophila melanogaster	176-192
17307740-0	2007	An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D. Autotaxin/NPP2, a secreted lysophospholipase-D, promotes cell proliferation, survival, and motility by generating the signaling molecule lysophosphatidic acid.	Polysaccharides	29-35	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	69-78
17307740-0	2007	An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D. Autotaxin/NPP2, a secreted lysophospholipase-D, promotes cell proliferation, survival, and motility by generating the signaling molecule lysophosphatidic acid.	Polysaccharides	29-35	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	112-121
17307740-0	2007	An essential oligomannosidic glycan chain in the catalytic domain of autotaxin, a secreted lysophospholipase-D. Autotaxin/NPP2, a secreted lysophospholipase-D, promotes cell proliferation, survival, and motility by generating the signaling molecule lysophosphatidic acid.	Polysaccharides	29-35	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	122-126
17301214-4	2007	In this study, we determined the efficacy of the human pneumococcal capsular polysaccharide serotype 3-specific antibody, A7 (immunoglobulin M [IgM]), in secretory IgM (sIgM)(-/-), CD4(-/-), CD8(-/-), muMT(-/-), and SCID mice and investigated its effect on cytokine and chemokine expression in sera and spleens from mice with intact cellular immunity.	Polysaccharides	77-91	CD4 molecule	Homo sapiens	181-184
17301214-4	2007	In this study, we determined the efficacy of the human pneumococcal capsular polysaccharide serotype 3-specific antibody, A7 (immunoglobulin M [IgM]), in secretory IgM (sIgM)(-/-), CD4(-/-), CD8(-/-), muMT(-/-), and SCID mice and investigated its effect on cytokine and chemokine expression in sera and spleens from mice with intact cellular immunity.	Polysaccharides	77-91	CD8a molecule	Homo sapiens	191-194
17397399-1	2007	Wnt-3a is a representative ligand that activates the beta-catenin-dependent pathway in Wnt signaling and is modified with glycans and palmitate.	Polysaccharides	122-129	Wnt family member 3A	Homo sapiens	0-6
17397399-1	2007	Wnt-3a is a representative ligand that activates the beta-catenin-dependent pathway in Wnt signaling and is modified with glycans and palmitate.	Polysaccharides	122-129	catenin beta 1	Homo sapiens	53-65
17397399-1	2007	Wnt-3a is a representative ligand that activates the beta-catenin-dependent pathway in Wnt signaling and is modified with glycans and palmitate.	Polysaccharides	122-129	Wnt family member 3A	Homo sapiens	0-3
17307740-5	2007	Consistent with a structural role for the Asn-524-linked glycan, only the mutation of Asn-524 augmented the sensitivity of NPP2 to proteolysis and increased its mobility during Blue Native PAGE.	Polysaccharides	57-63	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	123-127
17307740-7	2007	Our study defines an essential role for the Asn-524-linked glycan chain of NPP2.	Polysaccharides	59-65	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	75-79
17229815-3	2007	Previous studies showed that RNase 1 from human healthy pancreas contained only neutral glycans, whereas RNase 1 from PaC cell lines contained sialylated structures.	Polysaccharides	88-95	ribonuclease A family member 1, pancreatic	Homo sapiens	29-36
17229815-4	2007	To determine whether these glycan tumor cell-associated changes were also characteristic of serum RNase 1 and could be used as a marker of PaC, we have analyzed the glycosylation of serum RNase 1.	Polysaccharides	27-33	ribonuclease A family member 1, pancreatic	Homo sapiens	98-105
17229815-6	2007	Serum RNase 1 from two PaC patients and two controls was purified and the glycans analyzed by high-performance liquid chromatography (HPLC)-based sequencing and mass spectrometry.	Polysaccharides	74-81	ribonuclease A family member 1, pancreatic	Homo sapiens	6-13
17229815-7	2007	Although normal and tumor serum RNase 1 contained the same glycan structures, there was an increase of 40% in core fucosylation in the main sialylated biantennary glycans in the PaC serum RNase 1.	Polysaccharides	59-65	ribonuclease A family member 1, pancreatic	Homo sapiens	32-39
17229815-7	2007	Although normal and tumor serum RNase 1 contained the same glycan structures, there was an increase of 40% in core fucosylation in the main sialylated biantennary glycans in the PaC serum RNase 1.	Polysaccharides	163-170	ribonuclease A family member 1, pancreatic	Homo sapiens	188-195
17254634-8	2007	Thus, we identified extracellular polysaccharide from Lc.cremoris as an active substance that can induce immune activation via RP105 and MD-1.	Polysaccharides	34-48	CD180 molecule	Sus scrofa	127-132
17293006-5	2007	Here we report that PrP(c) glycans influence the capacity of PrP(c) from sheep brain or cultured Rov cells to bind IMAC columns loaded with Cu(2+) or Co(2+).	Polysaccharides	27-34	major prion protein	Ovis aries	20-26
17293006-5	2007	Here we report that PrP(c) glycans influence the capacity of PrP(c) from sheep brain or cultured Rov cells to bind IMAC columns loaded with Cu(2+) or Co(2+).	Polysaccharides	27-34	major prion protein	Ovis aries	61-67
17293006-7	2007	Our findings raise the possibility that the accessibility of the PrP(c) metal ion-binding sites might be controlled by the glycan chains.	Polysaccharides	123-129	major prion protein	Ovis aries	65-71
17170066-6	2007	These glycan epitopes decline markedly in cells undergoing the first definable step of differentiation, the transition from mESCs to primitive ectoderm (CD9(high) SSEA1(high) AP(high) DBA(low)).	Polysaccharides	6-12	CD9 antigen	Mus musculus	153-156
17170066-6	2007	These glycan epitopes decline markedly in cells undergoing the first definable step of differentiation, the transition from mESCs to primitive ectoderm (CD9(high) SSEA1(high) AP(high) DBA(low)).	Polysaccharides	6-12	fucosyltransferase 4	Mus musculus	163-168
17264077-3	2007	The activity of a Toll-like receptor, called Tollo/Toll-8, induces a pattern of incompletely defined, but neural specific, glycan expression in the Drosophila embryo.	Polysaccharides	123-129	tollo	Drosophila melanogaster	45-57
17319896-3	2007	Lipid-raft-independent apical carrier vesicles harbour the beta-galactoside-binding lectin galectin-3, which interacts directly with apical cargo in a glycan-dependent manner.	Polysaccharides	151-157	galectin 3	Canis lupus familiaris	91-101
17264077-9	2007	In tollo/toll-8 mutants, a dramatic, expected loss of difucosylated glycans is accompanied by unexpected decreases in monofucosylated and nonfucosylated hybrid glycans and increases in some nonfucosylated paucimannose and biantennary glycans.	Polysaccharides	68-75	tollo	Drosophila melanogaster	3-15
17264077-9	2007	In tollo/toll-8 mutants, a dramatic, expected loss of difucosylated glycans is accompanied by unexpected decreases in monofucosylated and nonfucosylated hybrid glycans and increases in some nonfucosylated paucimannose and biantennary glycans.	Polysaccharides	160-167	tollo	Drosophila melanogaster	3-15
17264077-9	2007	In tollo/toll-8 mutants, a dramatic, expected loss of difucosylated glycans is accompanied by unexpected decreases in monofucosylated and nonfucosylated hybrid glycans and increases in some nonfucosylated paucimannose and biantennary glycans.	Polysaccharides	160-167	tollo	Drosophila melanogaster	3-15
17264077-4	2007	Understanding the full extent of the changes in glycan expression that result from altered Tollo/Toll-8 signaling requires characterization of the complete N-linked glycan profile of both wild-type and mutant embryos.	Polysaccharides	48-54	tollo	Drosophila melanogaster	91-103
17264077-8	2007	Glycan profiles change during normal development consistent with increasing alpha-mannosidase II and core fucosyl-transferase enzyme activities, and with decreasing activity of the Fused lobes processing hexosaminidase.	Polysaccharides	0-6	alpha-Mannosidase class II a	Drosophila melanogaster	76-96
17305361-3	2007	Chemical analysis of tea polysaccharide conjugate showed that the tea polysaccharide conjugate was a nonstarch protein bounded acidic polysaccharide.	Polysaccharides	25-39	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	21-24
17305361-3	2007	Chemical analysis of tea polysaccharide conjugate showed that the tea polysaccharide conjugate was a nonstarch protein bounded acidic polysaccharide.	Polysaccharides	25-39	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	66-69
17305361-4	2007	The protein, neutral sugar, and uronic acid content of the tea polysaccharide conjugate was 3.5%, 44.2%, and 43.1%, respectively.	Polysaccharides	63-77	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	59-62
17305361-6	2007	Results showed that the contents of four elements in tea polysaccharide conjugate were much higher than that of tea power.	Polysaccharides	57-71	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	53-56
17305361-7	2007	Especially, the content of iron in tea polysaccharide conjugate was increased 5.9 times.	Polysaccharides	39-53	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	35-38
17305361-10	2007	On the basis of the study, the tea polysaccharide conjugate may be classified either as a very low toxicity substance, that is, GHS Category 5 (globally harmonized system), or as unclassified when orally administrated to mice.	Polysaccharides	35-49	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	31-34
17117926-3	2007	We found that Wnt-5a is modified with palmitate at Cys104 and glycans at Asn114, Asn120, Asn311 and Asn325.	Polysaccharides	62-69	Wnt family member 5A	Homo sapiens	14-20
17298961-6	2007	S2-566 an antibody specific for diNeu5Ac-containing glycans, recognized the CA-II, whereas an anti-oligo/polysialic acid antibody did not.	Polysaccharides	52-59	carbonic anhydrase 2	Homo sapiens	76-81
17082223-8	2007	To determine whether a specific glycosylation site or the number of glycans was critical for protein stability, we studied the protein expression of combinations of N-glycan-deficient mutants and observed that Bsep with one glycan was considerably unstable compared with Bsep harboring two or more glycans.	Polysaccharides	68-75	ATP binding cassette subfamily B member 11	Rattus norvegicus	210-214
17082223-8	2007	To determine whether a specific glycosylation site or the number of glycans was critical for protein stability, we studied the protein expression of combinations of N-glycan-deficient mutants and observed that Bsep with one glycan was considerably unstable compared with Bsep harboring two or more glycans.	Polysaccharides	298-305	ATP binding cassette subfamily B member 11	Rattus norvegicus	210-214
17145745-3	2007	So far, the glycan structure mediating the interaction of native ICAM-3 with DC-SIGN is undefined.	Polysaccharides	12-18	intercellular adhesion molecule 3	Homo sapiens	65-71
17145745-3	2007	So far, the glycan structure mediating the interaction of native ICAM-3 with DC-SIGN is undefined.	Polysaccharides	12-18	CD209 molecule	Homo sapiens	77-84
17172261-2	2007	L-selectin ligands are specific O-linked carbohydrates, 6-sulfo sialyl Lewis X, composed of sialylated, fucosylated, and sulfated glycans.	Polysaccharides	130-137	selectin, lymphocyte	Mus musculus	0-10
17241529-7	2007	CONCLUSION: It was suggested that alkaline extraction-isoelectric precipitated the polysaccharide fraction of A camphorata and had the ability to inhibit LPS-induced iNOS, IL-6, IL-10, MCP-5, and RANTES expression in mouse macrophages.	Polysaccharides	83-97	interleukin 10	Mus musculus	178-183
17034862-3	2007	In this study, we report interferon-gamma (IFN-gamma) stimulatory activity of fractionated Taenia glycans and Lewis sugars with comparable glycan composition.	Polysaccharides	98-104	interferon gamma	Mus musculus	43-52
17034862-8	2007	These data demonstrate the ability of Lewis type helminth glycans to modulate host responses in a Th-1 direction via NF-kappaB p65, IFN-gamma and macrophage TLRs.	Polysaccharides	58-65	interferon gamma	Mus musculus	132-141
17241529-7	2007	CONCLUSION: It was suggested that alkaline extraction-isoelectric precipitated the polysaccharide fraction of A camphorata and had the ability to inhibit LPS-induced iNOS, IL-6, IL-10, MCP-5, and RANTES expression in mouse macrophages.	Polysaccharides	83-97	chemokine (C-C motif) ligand 12	Mus musculus	185-190
17241529-7	2007	CONCLUSION: It was suggested that alkaline extraction-isoelectric precipitated the polysaccharide fraction of A camphorata and had the ability to inhibit LPS-induced iNOS, IL-6, IL-10, MCP-5, and RANTES expression in mouse macrophages.	Polysaccharides	83-97	chemokine (C-C motif) ligand 5	Mus musculus	196-202
17291077-1	2007	Platelet adhesion and activation induced by fibrinogen (Fbg) coating on polysaccharide layers of hyaluronic acid (Hyal) and its sulfated derivative (HyalS) were analyzed.	Polysaccharides	72-86	fibrinogen beta chain	Homo sapiens	44-54
17071728-1	2007	Pentosan polysulfate (PPS) is a heparin-like polysaccharide that can affect the binding interactions of fibroblast growth factor (FGF-2) with its high-affinity receptors.	Polysaccharides	45-59	fibroblast growth factor 2	Homo sapiens	130-135
17079030-6	2007	TNFalpha was found to induce apoptosis in chondrocytes, and this process was associated with significant changes in lectin binding to chondrocyte cell surface glycans.	Polysaccharides	159-166	tumor necrosis factor	Homo sapiens	0-8
17291077-1	2007	Platelet adhesion and activation induced by fibrinogen (Fbg) coating on polysaccharide layers of hyaluronic acid (Hyal) and its sulfated derivative (HyalS) were analyzed.	Polysaccharides	72-86	fibrinogen beta chain	Homo sapiens	56-59
17291077-3	2007	The Fbg coating was achieved by two different routes: the immobilization of Fbg by means of covalent bond to the polysaccharide layers and the mere adsorption of Fbg to Hyal and HyalS surfaces.	Polysaccharides	113-127	fibrinogen beta chain	Homo sapiens	4-7
17291077-3	2007	The Fbg coating was achieved by two different routes: the immobilization of Fbg by means of covalent bond to the polysaccharide layers and the mere adsorption of Fbg to Hyal and HyalS surfaces.	Polysaccharides	113-127	fibrinogen beta chain	Homo sapiens	76-79
17291077-3	2007	The Fbg coating was achieved by two different routes: the immobilization of Fbg by means of covalent bond to the polysaccharide layers and the mere adsorption of Fbg to Hyal and HyalS surfaces.	Polysaccharides	113-127	fibrinogen beta chain	Homo sapiens	76-79
17151241-1	2007	Adult Drosophila mutant for the glycosyltransferase beta1,4-N-acetlygalactosaminyltransferase-A (beta4GalNAcTA) display an abnormal locomotion phenotype, indicating a role for this enzyme, and the glycan structures that it generates, in the neuromuscular system.	Polysaccharides	197-203	beta1,4-N-acetylgalactosaminyltransferase A	Drosophila melanogaster	97-110
17170056-11	2007	The apoC-III IEF assay is likely to help metabolic laboratories to identify and unravel further subtypes of inborn errors of glycan biosynthesis.	Polysaccharides	125-131	apolipoprotein C3	Homo sapiens	4-12
17222224-4	2007	However, the disruption of late glycan processing, mainly performed by ER and Golgi alpha-1,2-mannosidases, on tyrosinase enzymatic activity and melanogenesis remains to be investigated.	Polysaccharides	32-38	tyrosinase	Homo sapiens	111-121
17393917-2	2007	A polysaccharide-rich precipitate of noni juice (noni-ppt) also stimulates tumor necrosis factor (TNF) and interleukin 1 (IL-1) in mice.	Polysaccharides	2-16	tumor necrosis factor	Mus musculus	75-96
17393917-2	2007	A polysaccharide-rich precipitate of noni juice (noni-ppt) also stimulates tumor necrosis factor (TNF) and interleukin 1 (IL-1) in mice.	Polysaccharides	2-16	tumor necrosis factor	Mus musculus	98-101
17393917-2	2007	A polysaccharide-rich precipitate of noni juice (noni-ppt) also stimulates tumor necrosis factor (TNF) and interleukin 1 (IL-1) in mice.	Polysaccharides	2-16	interleukin 1 complex	Mus musculus	107-126
16997964-3	2007	CD33-related Siglecs (CD33rSiglecs) are a family of Sia-binding lectins expressed on host leukocytes that engage host Sia-capped glycans and send signals that dampen inflammatory gene activation.	Polysaccharides	129-136	CD33 molecule	Homo sapiens	0-4
16997964-7	2007	Thus, production of Sia-capped bacterial polysaccharide capsules that mimic human cell surface glycans in order to engage CD33rSiglecs may be an example of a previously unrecognized bacterial mechanism of leukocyte manipulation.	Polysaccharides	41-55	CD33 molecule	Homo sapiens	122-126
16997964-7	2007	Thus, production of Sia-capped bacterial polysaccharide capsules that mimic human cell surface glycans in order to engage CD33rSiglecs may be an example of a previously unrecognized bacterial mechanism of leukocyte manipulation.	Polysaccharides	95-102	CD33 molecule	Homo sapiens	122-126
17209547-1	2007	Human UDP-glucose dehydrogenase (UGDH) is a homohexameric enzyme that catalyzes two successive oxidations of UDP-glucose to yield UDP-glucuronic acid, an essential precursor for matrix polysaccharide and proteoglycan synthesis.	Polysaccharides	185-199	UDP-glucose 6-dehydrogenase	Homo sapiens	6-31
17093292-7	2007	The natural basic polysaccharide, chitosan, also inhibited pancreatic lipase activity.	Polysaccharides	18-32	lipase G, endothelial type	Rattus norvegicus	70-76
17126533-7	2007	Our findings indicate that SIAT8B may be a candidate susceptibility gene for schizophrenia in the Chinese Han population and may also provide further support for the potential importance of polysaccharide-synthesizing genes in the etiology of schizophrenia.	Polysaccharides	190-204	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	27-33
17209547-1	2007	Human UDP-glucose dehydrogenase (UGDH) is a homohexameric enzyme that catalyzes two successive oxidations of UDP-glucose to yield UDP-glucuronic acid, an essential precursor for matrix polysaccharide and proteoglycan synthesis.	Polysaccharides	185-199	UDP-glucose 6-dehydrogenase	Homo sapiens	33-37
17354647-10	2007	The latter phenomenon will result in creating "holes" in the protective glycan shield of the HIV envelope, whereby the immune system may become triggered to produce neutralizing antibodies against previously hidden immunogenic epitopes of gp120.	Polysaccharides	72-78	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	239-244
17238283-1	2007	The addition of asparagine (N)-linked polysaccharide chains (i.e., glycans) to the gp120 and gp41 glycoproteins of human immunodeficiency virus type 1 (HIV-1) envelope is not only required for correct protein folding, but also may provide protection against neutralizing antibodies as a "glycan shield."	Polysaccharides	67-74	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	83-88
17238283-1	2007	The addition of asparagine (N)-linked polysaccharide chains (i.e., glycans) to the gp120 and gp41 glycoproteins of human immunodeficiency virus type 1 (HIV-1) envelope is not only required for correct protein folding, but also may provide protection against neutralizing antibodies as a "glycan shield."	Polysaccharides	67-73	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	83-88
17238283-8	2007	Mapping these interactions onto a structural model of HIV-1 gp120 reveals that negative (exclusive) interactions occur significantly more often between colocalized glycans, while positive (inclusive) interactions are restricted to more distant glycans.	Polysaccharides	164-171	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	60-65
17238283-8	2007	Mapping these interactions onto a structural model of HIV-1 gp120 reveals that negative (exclusive) interactions occur significantly more often between colocalized glycans, while positive (inclusive) interactions are restricted to more distant glycans.	Polysaccharides	244-251	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	60-65
17765706-5	2007	We explore two apparently distinct modes of host cell specificity, first that used by Minute virus of mice, where subtle glycan-specific interactions between host receptors and residues surrounding twofold symmetry axes on the virion surface mediate differentiated cell type target specificity, while the second involves novel protein interactions with the canine transferrin receptor that allow a mutant of the feline leukopenia serotype, Canine parvovirus, to bind to and infect dog cells.	Polysaccharides	121-127	inhibitor of carbonic anhydrase	Canis lupus familiaris	364-375
16940423-3	2007	Here we show that several members of the human galectin family of glycan binding proteins (galectins-1, -2, and -4) induce PS exposure in a carbohydrate-dependent fashion in activated, but not resting, human neutrophils and in several leukocyte cell lines.	Polysaccharides	66-72	galectin 1	Homo sapiens	91-114
18401077-5	2007	The zero shear viscosity (eta(0)) increased with increasing polysaccharide concentration (c) showing a gradient of approximately 1.0, 2.9 and 4.8 in different concentration domains.	Polysaccharides	60-74	endothelin receptor type A	Homo sapiens	26-29
16446085-1	2007	The effect of the protein-bound polysaccharide extracted from Glaciecola polaris (PSG) was investigated in vitro in the protection of oxidatively-injured mouse macrophages stressed by tert-butyl hydroperoxide (tbOOH) or by oxidatively modified low-density lipoprotein (Ox-LDL).	Polysaccharides	32-46	pregnancy specific glycoprotein 16	Mus musculus	82-85
17177967-1	2007	Mannan-binding lectin (MBL) binds microorganisms via interactions with glycans on the target surface.	Polysaccharides	71-78	mannose binding lectin 2	Homo sapiens	0-21
16941124-2	2007	Binding and endocytosis of betaGalactosidase (betaGal) are independent from the Fc and complement receptors, because sulfated polysaccharides, in a concentration manner, inhibit the bacterial antigen uptake.	Polysaccharides	126-141	galactosidase beta 1	Gallus gallus	27-44
17177967-1	2007	Mannan-binding lectin (MBL) binds microorganisms via interactions with glycans on the target surface.	Polysaccharides	71-78	mannose binding lectin 2	Homo sapiens	23-26
17640158-6	2007	Fitting dietary fiber together with soluble and insoluble nonstarch polysaccharides (NSP) showed a much greater decrease in E1 and E2 (47% and 41%, respectively) while increased soluble NSP intake showed increases in E1 and E2 (64% and 69%, respectively).	Polysaccharides	68-83	small nucleolar RNA, H/ACA box 73A	Homo sapiens	124-133
17495438-5	2007	Specifically, various preparations of human IgA1 with modified glycan moieties formed IC in vitro when incubated with sera from IgAN patients or healthy individuals, cord blood serum, or tissue culture supernatants of EBV-immortalized peripheral blood B cells secreting IgG.	Polysaccharides	63-69	immunoglobulin heavy constant alpha 1	Homo sapiens	44-48
18057039-0	2007	Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls.	Polysaccharides	106-121	UDP-glucose 6-dehydrogenase 1	Glycine max	28-53
17050611-9	2007	PRM-A represents the first prototype compound of a nonpeptidic CBA lead and, together with peptide-based lectins, belongs to a conceptually novel type of potential therapeutics for which drug pressure results in the selection of glycan deletions in the HIV gp120 envelope.	Polysaccharides	229-235	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	257-262
17947995-1	2007	Frontal affinity chromatography using fluorescence detection (FAC-FD) is a versatile technique for the precise determination of dissociation constants (Kd) between glycan-binding proteins (lectins) and fluorescent-labeled glycans.	Polysaccharides	222-229	FA complementation group C	Homo sapiens	62-65
17507872-4	2007	Fucose can be alpha 1,2, alpha 1,3, alpha 1,4, and alpha 1,6 linked to the glycans of glycoconjugates.	Polysaccharides	75-82	adrenoceptor alpha 1D	Homo sapiens	14-58
17264540-4	2007	RESULTS: Spontaneous colorectal tumors from Smad3 (-/-) homozygous null mice were found to express alpha(1,2)fucosylated glycans in an abnormal pattern compared to adjacent nonneoplastic colon.	Polysaccharides	121-128	SMAD family member 3	Mus musculus	44-49
17176047-2	2006	Glycans derived from MMP-9 expressed in MCF-7 breast cancer and THP-1 myeloid leukemia cells were compared with those from MMP-9 expressed in natural neutrophils.	Polysaccharides	0-7	matrix metallopeptidase 9	Homo sapiens	21-26
17071611-2	2006	Assembly occurs in the endoplasmic reticulum (ER) and involves the initial glycan-dependent association of the free heavy chain with calreticulin and calnexin and the thiol oxidoreductase ERp57.	Polysaccharides	75-81	calreticulin	Homo sapiens	133-145
17071611-2	2006	Assembly occurs in the endoplasmic reticulum (ER) and involves the initial glycan-dependent association of the free heavy chain with calreticulin and calnexin and the thiol oxidoreductase ERp57.	Polysaccharides	75-81	calnexin	Homo sapiens	150-158
17071611-7	2006	However, one glycan, glycan 2 at Asn-42, proved to be of particular importance for the stability of the CD1d-beta(2)m heterodimer.	Polysaccharides	13-19	CD1d molecule	Homo sapiens	104-108
17071611-7	2006	However, one glycan, glycan 2 at Asn-42, proved to be of particular importance for the stability of the CD1d-beta(2)m heterodimer.	Polysaccharides	13-19	beta-2-microglobulin	Homo sapiens	109-117
17071611-9	2006	A mutant expressing only glycan 1 dissociated completely from beta(2)m upon exposure to the detergent Triton X-100, whereas a mutant expressing only glycan 2 at Asn-42 was more stable.	Polysaccharides	25-31	beta-2-microglobulin	Homo sapiens	62-70
17071611-11	2006	Modeling the glycans on the published structure indicated that glycan 2 interacts significantly with both the CD1d heavy chain and beta(2)m, which may explain these unusual properties.	Polysaccharides	13-20	CD1d molecule	Homo sapiens	110-114
17071611-11	2006	Modeling the glycans on the published structure indicated that glycan 2 interacts significantly with both the CD1d heavy chain and beta(2)m, which may explain these unusual properties.	Polysaccharides	13-20	beta-2-microglobulin	Homo sapiens	131-139
17546990-6	2007	Moreover, ATR-FTIR spectra of the fouled membranes were modified, mainly in a broad complex region corresponding to polysaccharides and nucleic acids.	Polysaccharides	116-131	ATR serine/threonine kinase	Homo sapiens	10-13
17176047-4	2006	The glycan epitopes thus provide MMP-9 with both high-affinity and (presumably) high-avidity interactions with galectin-3.	Polysaccharides	4-10	matrix metallopeptidase 9	Homo sapiens	33-38
17176047-4	2006	The glycan epitopes thus provide MMP-9 with both high-affinity and (presumably) high-avidity interactions with galectin-3.	Polysaccharides	4-10	galectin 3	Homo sapiens	111-121
17176047-6	2006	Only 10% of MCF-7 and THP-1 gelatinase B O-glycans were ligands for galectin-3 and contained only a maximum single N-acetyllactosamine repeat.	Polysaccharides	43-50	galectin 3	Homo sapiens	68-78
17176047-7	2006	Consistent with the glycan analysis, surface plasmon resonance binding assays indicated that the cancer-associated glycoforms of MMP-9 bound galectin-3 with an affinity and avidity significantly reduced compared with those of the natural neutrophil MMP-9.	Polysaccharides	20-26	matrix metallopeptidase 9	Homo sapiens	129-134
16880503-0	2006	Site-specific glycan analysis of human chorionic gonadotropin beta-subunit from malignancies and pregnancy by liquid chromatography--electrospray mass spectrometry.	Polysaccharides	14-20	chorionic gonadotropin subunit beta 5	Homo sapiens	39-74
17147426-4	2006	Strains deleted for GAS1, GPI7, or KNR4 release higher amounts of mannoproteins and polysaccharides to the medium.	Polysaccharides	84-99	1,3-beta-glucanosyltransferase GAS1	Saccharomyces cerevisiae S288C	20-24
17147426-4	2006	Strains deleted for GAS1, GPI7, or KNR4 release higher amounts of mannoproteins and polysaccharides to the medium.	Polysaccharides	84-99	mannose-ethanolamine phosphotransferase LAS21	Saccharomyces cerevisiae S288C	26-30
17147426-4	2006	Strains deleted for GAS1, GPI7, or KNR4 release higher amounts of mannoproteins and polysaccharides to the medium.	Polysaccharides	84-99	Smi1p	Saccharomyces cerevisiae S288C	35-39
17052671-1	2006	We reported previously that a high molecular weight polysaccharide fraction (Immulina) from Spirulina was a potent activator of NF-kappa B and induced both IL-1 beta and TNF-alpha mRNAs in THP-1 human monocytes.	Polysaccharides	52-66	nuclear factor kappa B subunit 1	Homo sapiens	128-138
17052671-1	2006	We reported previously that a high molecular weight polysaccharide fraction (Immulina) from Spirulina was a potent activator of NF-kappa B and induced both IL-1 beta and TNF-alpha mRNAs in THP-1 human monocytes.	Polysaccharides	52-66	interleukin 1 beta	Homo sapiens	156-165
17052671-1	2006	We reported previously that a high molecular weight polysaccharide fraction (Immulina) from Spirulina was a potent activator of NF-kappa B and induced both IL-1 beta and TNF-alpha mRNAs in THP-1 human monocytes.	Polysaccharides	52-66	tumor necrosis factor	Homo sapiens	170-179
17142960-4	2006	In agreement with this interpretation, an oligosaccharide analysis indicated that 6-sulfo sialyl Lewis X, a major L-selectin ligand sulfated glycan, is almost completely abrogated in the double-deficient mice.	Polysaccharides	141-147	selectin, lymphocyte	Mus musculus	114-124
17049214-0	2006	Development and characterization of new insulin containing polysaccharide nanoparticles.	Polysaccharides	59-73	insulin	Homo sapiens	40-47
16880503-4	2006	These glycoforms, which are called "hyperglycosylated" hCG (hCGh), have been reported to contain more complex glycan moieties.	Polysaccharides	110-116	hypertrichosis 2 (generalised, congenital)	Homo sapiens	55-58
16880503-4	2006	These glycoforms, which are called "hyperglycosylated" hCG (hCGh), have been reported to contain more complex glycan moieties.	Polysaccharides	110-116	hypertrichosis 2 (generalised, congenital)	Homo sapiens	60-64
16880503-12	2006	The glycans of free hCGbeta were larger and had a higher fucose content of Asn-13-linked oligosaccharides than intact hCG.	Polysaccharides	4-11	hypertrichosis 2 (generalised, congenital)	Homo sapiens	20-23
16880503-14	2006	Analysis of hCGh affinity purified with antibody B152 confirmed that this antibody recognizes a core-2 glycan on Ser-132.	Polysaccharides	103-109	hypertrichosis 2 (generalised, congenital)	Homo sapiens	12-16
17018527-9	2006	Conclusively, we have provided evidence for the existence of an equilibrium between active PAI-1 and a pre-latent form, characterized by reversible detachment of s1C and formation of a glycan-shielded cleft in the molecule.	Polysaccharides	185-191	serpin family E member 1	Homo sapiens	91-96
17050773-11	2006	Quantitative analysis of N-linked glycosylation of IgA heavy chains showed significant differences in glycan composition between mIgA and pIgA, including the presence of oligomannose exclusively on pIgA.	Polysaccharides	102-108	immunoglobulin heavy constant alpha	Mus musculus	51-54
17050773-11	2006	Quantitative analysis of N-linked glycosylation of IgA heavy chains showed significant differences in glycan composition between mIgA and pIgA, including the presence of oligomannose exclusively on pIgA.	Polysaccharides	102-108	immunoglobulin heavy constant alpha	Mus musculus	129-133
17050773-11	2006	Quantitative analysis of N-linked glycosylation of IgA heavy chains showed significant differences in glycan composition between mIgA and pIgA, including the presence of oligomannose exclusively on pIgA.	Polysaccharides	102-108	phosphatidylinositol glycan anchor biosynthesis class A	Homo sapiens	138-142
17156729-7	2006	IgMhigh IgDlow CD27+ B cells are a puzzling population apparently specialized in T-independent responses to bacterial capsular polysaccharides.	Polysaccharides	127-142	CD27 molecule	Homo sapiens	15-19
17003032-1	2006	Polysialic acid is a developmentally regulated, anti-adhesive glycan that is added to the neural cell adhesion molecule, NCAM.	Polysaccharides	62-68	neural cell adhesion molecule 1	Homo sapiens	121-125
16427262-1	2006	A sulphated polysaccharide (SP-2a) from the brown alga Sargassum patens (Kutz.)	Polysaccharides	12-26	surfactant protein A2	Homo sapiens	28-33
17155778-2	2006	Individual polysaccharide chains were covalently pinned to the surface with one segment and picked up randomly with an atomic force microscope tip.	Polysaccharides	11-25	TOR signaling pathway regulator	Homo sapiens	143-146
17086202-0	2006	Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein.	Polysaccharides	40-55	membrane protein	Escherichia coli	79-95
17096537-5	2006	The intrinsic viscosity, [eta], of the polysaccharide in Milli-Q water was 1030 +/- 20 mL/g.	Polysaccharides	39-53	endothelin receptor type A	Homo sapiens	26-29
17070198-11	2006	The mAb may be more useful in assessing glycodelin expression in endometrium, because it probably can bind to glycodelin A-unique glycan structures, in contrast to the peptide pAb.	Polysaccharides	130-136	progestagen associated endometrial protein	Homo sapiens	40-50
17070198-11	2006	The mAb may be more useful in assessing glycodelin expression in endometrium, because it probably can bind to glycodelin A-unique glycan structures, in contrast to the peptide pAb.	Polysaccharides	130-136	progestagen associated endometrial protein	Homo sapiens	110-122
16979118-5	2006	Four of the polysaccharides upregulated IL-10 secretion by the dendritic cells, as compared with unstimulated cells, the beta-glucans lichenan and Ths-2 and the heteroglycans Pc-4 and thamnolan.	Polysaccharides	12-27	interleukin 10	Homo sapiens	40-45
16979118-5	2006	Four of the polysaccharides upregulated IL-10 secretion by the dendritic cells, as compared with unstimulated cells, the beta-glucans lichenan and Ths-2 and the heteroglycans Pc-4 and thamnolan.	Polysaccharides	12-27	threonine synthase like 2	Homo sapiens	147-152
16979118-5	2006	Four of the polysaccharides upregulated IL-10 secretion by the dendritic cells, as compared with unstimulated cells, the beta-glucans lichenan and Ths-2 and the heteroglycans Pc-4 and thamnolan.	Polysaccharides	12-27	SUB1 regulator of transcription	Homo sapiens	175-179
16979118-9	2006	Therefore, these polysaccharides could be considered suitable candidates in tolerance and anti-inflammatory studies, as IL-10 is one of the major cytokines involved in tolerance and anti-inflammatory responses.	Polysaccharides	17-32	interleukin 10	Homo sapiens	120-125
16972014-4	2006	The diversification of CD33-related Siglecs may be driven by direct competition against pathogens, and/or by necessity to catch up with the changing landscape of endogenous glycans, which may in turn be changing to escape exploitation by other pathogens.	Polysaccharides	173-180	CD33 molecule	Homo sapiens	23-27
17082598-1	2006	A microbial polysaccharide (glucuronoxylomannan (GXM)) exerts potent immunosuppression by direct engagement to immunoinhibitory receptor FcgammaRIIB.	Polysaccharides	12-26	Fc gamma receptor IIb	Homo sapiens	137-148
17088551-7	2006	These studies demonstrate that the C-terminal domain binds to the mannose moieties of N-linked oligosaccharide chains, and we further show that it enhances the activity of the mouse PNGase core domain, presumably by increasing the affinity of mouse PNGase for the glycan chains of misfolded glycoproteins.	Polysaccharides	264-270	N-glycanase 1	Mus musculus	182-188
17088551-7	2006	These studies demonstrate that the C-terminal domain binds to the mannose moieties of N-linked oligosaccharide chains, and we further show that it enhances the activity of the mouse PNGase core domain, presumably by increasing the affinity of mouse PNGase for the glycan chains of misfolded glycoproteins.	Polysaccharides	264-270	N-glycanase 1	Mus musculus	249-255
17059404-1	2006	The Arabidopsis radial swelling mutant rsw10 showed ballooning of root trichoblasts, a lower than wild-type level of cellulose and altered levels of some monosaccharides in non-cellulosic polysaccharides.	Polysaccharides	188-203	Ribose 5-phosphate isomerase, type A protein	Arabidopsis thaliana	39-44
16427262-5	2006	The inhibitory effect of SP-2a on virus adsorption occurred dose-dependently in all the HSV-1 strains tested, and the adsorption of the ACV-resistant DM2.1 strain was reduced by 81.9% (relative to control) with 4 microg/ml of the polysaccharide.	Polysaccharides	230-244	surfactant protein A2	Homo sapiens	25-30
16427262-6	2006	This study clearly demonstrated that the antiviral mode of action of SP-2a is mediated mainly by inhibiting virus attachment to host cells, and this sulphated polysaccharide might have different modes of action against the ACV-sensitive and -resistant strains of HSV-1.	Polysaccharides	159-173	surfactant protein A2	Homo sapiens	69-74
17067392-9	2006	Oxidation of the MUC16 glycans, removal of its N-linked oligosaccharides, and treatment of the mucin with wheat germ agglutinin and erythroagglutinating phytohemagglutinin abrogates its binding to mesothelin.	Polysaccharides	23-30	mucin 16, cell surface associated	Homo sapiens	17-22
16895906-2	2006	The CD33-related siglecs show complex recognition patterns for sialylated glycans.	Polysaccharides	74-81	CD33 molecule	Homo sapiens	4-8
16979599-5	2006	Our analysis produces a tentative model of the core region of the Reelin subrepeat sequences and suggests the presence in this 3D model of structural features common to polysaccharide-binding modules which are often found on proteoglycans of the ECM.	Polysaccharides	169-183	reelin	Homo sapiens	66-72
16940048-2	2006	Monoglucosylated glycans, such as Glc1-Man9GlcNAc2, generated by this process play a key role in glycoprotein quality control in the ER, because they are primary ligands for the lectin chaperones calnexin (CNX) and calreticulin (CRT).	Polysaccharides	17-24	calnexin	Homo sapiens	196-204
16940048-2	2006	Monoglucosylated glycans, such as Glc1-Man9GlcNAc2, generated by this process play a key role in glycoprotein quality control in the ER, because they are primary ligands for the lectin chaperones calnexin (CNX) and calreticulin (CRT).	Polysaccharides	17-24	calnexin	Homo sapiens	206-209
16940048-2	2006	Monoglucosylated glycans, such as Glc1-Man9GlcNAc2, generated by this process play a key role in glycoprotein quality control in the ER, because they are primary ligands for the lectin chaperones calnexin (CNX) and calreticulin (CRT).	Polysaccharides	17-24	calreticulin	Homo sapiens	215-227
16940048-2	2006	Monoglucosylated glycans, such as Glc1-Man9GlcNAc2, generated by this process play a key role in glycoprotein quality control in the ER, because they are primary ligands for the lectin chaperones calnexin (CNX) and calreticulin (CRT).	Polysaccharides	17-24	calreticulin	Homo sapiens	229-232
16901901-5	2006	Furthermore, this activity is unique to laforin, since several other phosphatases are unable to dephosphorylate polysaccharides.	Polysaccharides	112-127	EPM2A glucan phosphatase, laforin	Homo sapiens	40-47
16721788-9	2006	We could further demonstrate that breast cancer cells expressed EMMPRIN isoforms differing in the presence or absence of Lewis X glycan structures.	Polysaccharides	129-135	basigin (Ok blood group)	Homo sapiens	64-71
17015718-9	2006	In addition, these studies demonstrate that different T cell glycoproteins on the same cell have distinct requirements for glycan modifications that allow recognition and cross-linking by galectin-1.	Polysaccharides	123-129	galectin 1	Homo sapiens	188-198
16984999-8	2006	Domain 2 of EXPB1 is an Ig-like beta-sandwich, with aromatic and polar residues that form a potential surface for polysaccharide binding in line with the glycan binding cleft of domain 1.	Polysaccharides	114-128	expansin-B1	Zea mays	12-17
16984999-5	2006	EXPB1 consists of two domains closely packed and aligned so as to form a long, shallow groove with potential to bind a glycan backbone of approximately 10 sugar residues.	Polysaccharides	119-125	expansin-B1	Zea mays	0-5
16984999-8	2006	Domain 2 of EXPB1 is an Ig-like beta-sandwich, with aromatic and polar residues that form a potential surface for polysaccharide binding in line with the glycan binding cleft of domain 1.	Polysaccharides	154-160	expansin-B1	Zea mays	12-17
16757156-0	2006	Polysaccharide differences between planktonic and biofilm-associated EPS from Pseudomonas fluorescens B52.	Polysaccharides	0-14	serine and arginine rich splicing factor 6	Homo sapiens	102-105
16958115-2	2006	We tested the therapeutic potential of functional mimics of the human natural killer cell glycan (3-sulfoglucuronyl beta1-3 galactoside) (HNK-1) epitope, a carbohydrate indicated to favor specificity of motor reinnervation in mice.	Polysaccharides	90-96	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	116-123
17012248-5	2006	Human Siglec-14 has almost complete sequence identity with human Siglec-5 at the first two Ig-like domains, shows a glycan binding preference similar to that of human Siglec-5, and associates with the activating adapter protein DAP12.	Polysaccharides	116-122	sialic acid binding Ig like lectin 14	Homo sapiens	6-15
17012248-5	2006	Human Siglec-14 has almost complete sequence identity with human Siglec-5 at the first two Ig-like domains, shows a glycan binding preference similar to that of human Siglec-5, and associates with the activating adapter protein DAP12.	Polysaccharides	116-122	sialic acid binding Ig like lectin 5	Homo sapiens	65-73
16569440-8	2006	CBP presumably act by direct binding to the glycans that are abundantly present on the HIV-1 gp120 envelope.	Polysaccharides	44-51	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	93-98
16857734-2	2006	Its sialic acid-binding activity on NK cells is masked by cis interactions with sialylated glycans, which are likely to be important for regulating the inhibitory function of Siglec-7, which exhibits an unusual preference for alpha2,8-linked disialic acids, a motif found in "b-series" gangliosides and some glycoproteins.	Polysaccharides	91-98	sialic acid binding Ig like lectin 7	Homo sapiens	175-183
16828561-3	2006	In order to obtain sufficiently soluble model compounds, glycan side chains of T-antigen, (2,6)sialyl T-antigen and sialyl TN-antigen structure were linked to the serine located in the supposed turn sequence of the LI-cadherin recognition domain.	Polysaccharides	57-63	cadherin 17	Mus musculus	215-226
16829530-8	2006	Modeling of such glycan structures on the receptor protein suggests that at least some may be strategically positioned to interfere with interactions of the receptor with FGF ligand and/or the HS co-receptor.	Polysaccharides	17-23	fibroblast growth factor 2	Homo sapiens	171-174
16929095-8	2006	The amino-acid sequence determination of SPC-40 reveals two potential N-glycosylation sites at Asn39 and Asn345, but electron density for a glycan chain was only present at Asn39.	Polysaccharides	140-146	chitinase 3 like 1	Bos taurus	41-47
16982914-2	2006	Previous studies have indicated the possibility for diversity in the synthesis of E- and P-selectin glycan ligands by activated T cells due to their different requirements for the O-glycan branching enzyme core 2 beta1,6-N-acetylglucosaminyltransferase I and its independent regulation.	Polysaccharides	100-106	selectin P	Homo sapiens	89-99
16982914-2	2006	Previous studies have indicated the possibility for diversity in the synthesis of E- and P-selectin glycan ligands by activated T cells due to their different requirements for the O-glycan branching enzyme core 2 beta1,6-N-acetylglucosaminyltransferase I and its independent regulation.	Polysaccharides	100-106	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	206-254
16982914-4	2006	The mAb CHO-131 and P-selectin binding require a glycan moiety consisting of a sialylated and fucosylated oligosaccharide properly positioned on a core-2 O-glycan.	Polysaccharides	49-55	selectin P	Homo sapiens	20-30
19372833-4	2006	Prolonged exposure to carbohydrate-binding agents slowly and progressively selects for deletions of glycans at N-glycosylation sites in HIV gp120.	Polysaccharides	100-107	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	140-145
16844835-5	2006	We demonstrate that in log phase-oscillating cultures, GBSSI is required to obtain maximal polysaccharide content and fully compensates for the loss of soluble starch synthase III.	Polysaccharides	91-105	uncharacterized protein	Chlamydomonas reinhardtii	55-60
16912292-6	2006	The level of phenotypic resistance of the mutated virus strains against CV-N generally correlated with the number of glycan deletions in gp120, although deletion of the glycans at N-230, N-392, and N-448 generally afforded a more pronounced CV-N resistance than other N-glycan deletions.	Polysaccharides	117-123	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	137-142
19372833-6	2006	Moreover, virus strains that contain deleted glycans in their gp120 envelope may trigger the immune system to produce neutralizing antibodies against the uncovered immunogenic epitopes on HIV gp120, contributing further to the elimination of the mutant virus particles from the bloodstream.	Polysaccharides	45-52	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	62-67
19372833-6	2006	Moreover, virus strains that contain deleted glycans in their gp120 envelope may trigger the immune system to produce neutralizing antibodies against the uncovered immunogenic epitopes on HIV gp120, contributing further to the elimination of the mutant virus particles from the bloodstream.	Polysaccharides	45-52	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	192-197
16807242-2	2006	Specific p97 functions are mediated by a variety of cofactors, among them peptide N-glycanase, an enzyme that removes glycans from misfolded glycoproteins.	Polysaccharides	118-125	melanotransferrin	Homo sapiens	9-12
16807242-2	2006	Specific p97 functions are mediated by a variety of cofactors, among them peptide N-glycanase, an enzyme that removes glycans from misfolded glycoproteins.	Polysaccharides	118-125	N-glycanase 1	Homo sapiens	74-93
16920935-1	2006	CD22 (Siglec-2) is a key regulator of B cell signaling whose function is modulated by interaction with extracellular glycan ligands mediated through its N-terminal Ig domain.	Polysaccharides	117-123	CD22 molecule	Homo sapiens	0-4
16920935-1	2006	CD22 (Siglec-2) is a key regulator of B cell signaling whose function is modulated by interaction with extracellular glycan ligands mediated through its N-terminal Ig domain.	Polysaccharides	117-123	CD22 molecule	Homo sapiens	6-14
16945187-6	2006	Further structural analyses revealed that P1-a was a polysaccharide-peptide complex, and P1-b was a polymer consisting of acteoside and acteoside derivatives identified by Fourier transform infrared spectroscopy, nuclear magnetic resonance, assays of carbohydrate and protein contents and high-performance liquid chromatography electrospray ionization mass spectrometry.	Polysaccharides	53-67	zinc finger protein 185 with LIM domain	Homo sapiens	42-46
16757497-1	2006	BACKGROUND: Sera of IgA nephropathy (IgAN) patients contain high levels of circulating immune complexes composed of IgA1 molecules with aberrantly glycosylated hinge-region O-linked oligosaccharides and IgG or IgA1 antibodies with anti-glycan or anti-hinge-region peptide specificities.	Polysaccharides	236-242	IGAN1	Homo sapiens	20-35
16757497-1	2006	BACKGROUND: Sera of IgA nephropathy (IgAN) patients contain high levels of circulating immune complexes composed of IgA1 molecules with aberrantly glycosylated hinge-region O-linked oligosaccharides and IgG or IgA1 antibodies with anti-glycan or anti-hinge-region peptide specificities.	Polysaccharides	236-242	IGAN1	Homo sapiens	37-41
16757497-1	2006	BACKGROUND: Sera of IgA nephropathy (IgAN) patients contain high levels of circulating immune complexes composed of IgA1 molecules with aberrantly glycosylated hinge-region O-linked oligosaccharides and IgG or IgA1 antibodies with anti-glycan or anti-hinge-region peptide specificities.	Polysaccharides	236-242	immunoglobulin heavy constant alpha 1	Homo sapiens	116-120
16712766-4	2006	In addition, CE-MS was used to confirm major 8-aminopyrene-1,3,6-trisulfonate (APTS)-labeled glycans released from recombinant antibodies that are routinely profiled by CE-laser-induced fluorescence (CE-LIF).	Polysaccharides	93-100	LIF interleukin 6 family cytokine	Homo sapiens	203-206
16916459-18	2006	Cell surface glycans, such as ABO and related antigens have special relevance in reproductive biology and could modulate specific cell interactions as those associated with the pathogenesis of placental malaria.	Polysaccharides	13-20	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	30-33
16888005-3	2006	Surprisingly, the major change observed in activated CD4 and CD8 T cells was a dramatic reduction of sialylated biantennary N-glycans carrying the terminal NeuGcalpha2-6Gal sequence, and a corresponding increase in glycans carrying the Galalpha1-3Gal sequence.	Polysaccharides	126-133	CD4 antigen	Mus musculus	53-56
16814399-5	2006	MBL binds agalactosylated glycoforms of IgG (IgG-G0), polymeric forms of IgA and certain glycoforms of IgM which have a high incidence of GlcNAc-terminating glycans.	Polysaccharides	157-164	mannose binding lectin 2	Homo sapiens	0-3
17369931-2	2006	A correlation was found between the increase in chemiluminescence (Re-LPS&lt;Ra-LPS&lt;S-LPS) and lengthening of the polysaccharide chain in endotoxins.	Polysaccharides	117-131	interferon regulatory factor 6	Homo sapiens	70-73
16780802-0	2006	The influence of various structural parameters of semisynthetic sulfated polysaccharides on the P-selectin inhibitory capacity.	Polysaccharides	73-88	selectin P	Homo sapiens	96-106
16770529-7	2006	Thus induction of cell death by LAAO appears to involve both the generation of H2O2 and the molecular interaction of the glycan moiety of the enzyme with structures at the cell surface.	Polysaccharides	121-127	interleukin 4 induced 1	Homo sapiens	32-36
16647263-0	2006	High-mannose-type glycan modifications of dihydrofolate reductase using glycan-methotrexate conjugates.	Polysaccharides	18-24	dihydrofolate reductase	Homo sapiens	42-65
16647263-1	2006	Various high-mannose-type glycan modifications of dihydrofolate reductase (DHFR) were achieved by ligand-based approach using glycan-methotrexate (MTX) conjugates as tight binding glycan bearing ligands for DHFR.	Polysaccharides	26-32	dihydrofolate reductase	Homo sapiens	50-73
16647263-1	2006	Various high-mannose-type glycan modifications of dihydrofolate reductase (DHFR) were achieved by ligand-based approach using glycan-methotrexate (MTX) conjugates as tight binding glycan bearing ligands for DHFR.	Polysaccharides	26-32	dihydrofolate reductase	Homo sapiens	75-79
16647263-1	2006	Various high-mannose-type glycan modifications of dihydrofolate reductase (DHFR) were achieved by ligand-based approach using glycan-methotrexate (MTX) conjugates as tight binding glycan bearing ligands for DHFR.	Polysaccharides	26-32	dihydrofolate reductase	Homo sapiens	207-211
16647263-1	2006	Various high-mannose-type glycan modifications of dihydrofolate reductase (DHFR) were achieved by ligand-based approach using glycan-methotrexate (MTX) conjugates as tight binding glycan bearing ligands for DHFR.	Polysaccharides	126-132	dihydrofolate reductase	Homo sapiens	50-73
16647263-1	2006	Various high-mannose-type glycan modifications of dihydrofolate reductase (DHFR) were achieved by ligand-based approach using glycan-methotrexate (MTX) conjugates as tight binding glycan bearing ligands for DHFR.	Polysaccharides	126-132	dihydrofolate reductase	Homo sapiens	75-79
16647263-1	2006	Various high-mannose-type glycan modifications of dihydrofolate reductase (DHFR) were achieved by ligand-based approach using glycan-methotrexate (MTX) conjugates as tight binding glycan bearing ligands for DHFR.	Polysaccharides	126-132	dihydrofolate reductase	Homo sapiens	207-211
17369931-2	2006	A correlation was found between the increase in chemiluminescence (Re-LPS&lt;Ra-LPS&lt;S-LPS) and lengthening of the polysaccharide chain in endotoxins.	Polysaccharides	117-131	interferon regulatory factor 6	Homo sapiens	80-83
17369931-2	2006	A correlation was found between the increase in chemiluminescence (Re-LPS&lt;Ra-LPS&lt;S-LPS) and lengthening of the polysaccharide chain in endotoxins.	Polysaccharides	117-131	interferon regulatory factor 6	Homo sapiens	80-83
16670103-3	2006	The major subunit of the rat asialoglycoprotein receptor and the rat Kupffer cell receptor show similar broad preferences for GalNAc-terminated glycans, while the rat macrophage galactose lectin and the human scavenger receptor C-type lectin (SRCL) bind more restricted sets of glycans.	Polysaccharides	144-151	C-type lectin domain family 4, member F	Rattus norvegicus	69-90
16918445-9	2006	Evidence based on work with CD4(+) T-hybridomas confirms that O-glycopeptides can be effectively presented to T-cells and that glycans can form integral parts of the TCR defined epitopes.	Polysaccharides	127-134	CD4 molecule	Homo sapiens	28-31
16670103-3	2006	The major subunit of the rat asialoglycoprotein receptor and the rat Kupffer cell receptor show similar broad preferences for GalNAc-terminated glycans, while the rat macrophage galactose lectin and the human scavenger receptor C-type lectin (SRCL) bind more restricted sets of glycans.	Polysaccharides	278-285	C-type lectin domain family 4, member F	Rattus norvegicus	69-90
16670103-5	2006	Although the similar glycan-binding profiles for the asialoglycoprotein receptor and the Kupffer cell receptor might suggest that these receptors are functionally redundant, analysis of fibroblasts transfected with full-length Kupffer cell receptor reveals that they fail to endocytose glycosylated ligand.	Polysaccharides	21-27	C-type lectin domain family 4, member F	Rattus norvegicus	227-248
16672288-5	2006	Fucosylated Man5GlcNAc2 glycans were also detected on recombinant glycoprotein from HEK 293T cells following inhibition of Golgi alpha-mannosidase II with swainsonine.	Polysaccharides	24-31	mannosidase alpha class 2A member 1	Homo sapiens	123-149
16864779-8	2006	Antigen-binding analyses confirm that selected TCL1 clones react with glycerophospholipid, lipoprotein, and polysaccharides that can be autoantigens and be expressed by microbes.	Polysaccharides	108-123	TCL1 family AKT coactivator A	Homo sapiens	47-51
16518858-1	2006	The tumor-associated antigen 90K (TAA90K)/Mac-2-binding protein implicated in cancer progression and metastasis is modified by beta1-6 branched N-linked oligosaccharides in colon cancer cells, glycans shown to contribute to cancer metastasis.	Polysaccharides	193-200	galectin 3 binding protein	Homo sapiens	4-32
16518858-1	2006	The tumor-associated antigen 90K (TAA90K)/Mac-2-binding protein implicated in cancer progression and metastasis is modified by beta1-6 branched N-linked oligosaccharides in colon cancer cells, glycans shown to contribute to cancer metastasis.	Polysaccharides	193-200	galectin 3 binding protein	Homo sapiens	34-40
16518858-1	2006	The tumor-associated antigen 90K (TAA90K)/Mac-2-binding protein implicated in cancer progression and metastasis is modified by beta1-6 branched N-linked oligosaccharides in colon cancer cells, glycans shown to contribute to cancer metastasis.	Polysaccharides	193-200	galectin 3	Homo sapiens	42-47
16518858-1	2006	The tumor-associated antigen 90K (TAA90K)/Mac-2-binding protein implicated in cancer progression and metastasis is modified by beta1-6 branched N-linked oligosaccharides in colon cancer cells, glycans shown to contribute to cancer metastasis.	Polysaccharides	193-200	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	127-134
16670374-2	2006	The polysaccharide from G. lucidum (PS-G) is a branched (1--&gt;6)-beta-d-glucan moiety.	Polysaccharides	4-18	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	36-40
16691546-0	2006	Effect of various extracts and a polysaccharide from the edible mycelia of Cordyceps sinensis on cellular and humoral immune response against ovalbumin in mice.	Polysaccharides	33-47	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	142-151
16682406-4	2006	Results from screening of a glycan array demonstrate that only mouse SIGNR3 shares with human DC-SIGN the ability to bind both high mannose and fucose-terminated glycans in this format and to mediate endocytosis.	Polysaccharides	28-34	CD209d antigen	Mus musculus	69-75
16844780-3	2006	A subset of the enzymes was used to fragment polysaccharides from the irregular xylem 9 (irx9) mutant of Arabidopsis.	Polysaccharides	45-60	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	89-93
16682406-4	2006	Results from screening of a glycan array demonstrate that only mouse SIGNR3 shares with human DC-SIGN the ability to bind both high mannose and fucose-terminated glycans in this format and to mediate endocytosis.	Polysaccharides	162-169	CD209d antigen	Mus musculus	69-75
16682406-6	2006	The data also reveal that two of the mouse SIGNs have unusual binding specificities that have not been previously described for members of the C-type lectin family; the newly identified SIGNR7 binds preferentially to the 6-sulfo-sialyl Lewis(x) oligosaccharide, whereas SIGNR2 binds almost exclusively to glycans that bear terminal GlcNAc residues.	Polysaccharides	305-312	CD209g antigen	Mus musculus	186-192
21638699-13	2006	The methodology described enables the demonstration of some biochemical properties of polysaccharides, namely animal and vegetable, and the catalytic activity of the human salivary alpha-amylase (EC.3.2.1.1) enzyme.	Polysaccharides	86-101	amylase alpha 1A	Homo sapiens	172-194
16713984-5	2006	By using the human C-type lectin DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin), we demonstrate that the biotinylated glycans can be used in a glycan array to determine binding specificities of lectins.	Polysaccharides	133-140	CD209 molecule	Homo sapiens	33-40
16713984-5	2006	By using the human C-type lectin DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin), we demonstrate that the biotinylated glycans can be used in a glycan array to determine binding specificities of lectins.	Polysaccharides	133-140	CD209 molecule	Homo sapiens	42-93
16713984-5	2006	By using the human C-type lectin DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin), we demonstrate that the biotinylated glycans can be used in a glycan array to determine binding specificities of lectins.	Polysaccharides	133-139	CD209 molecule	Homo sapiens	33-40
16713984-5	2006	By using the human C-type lectin DC-SIGN (dendritic cell-specific ICAM-3-grabbing nonintegrin), we demonstrate that the biotinylated glycans can be used in a glycan array to determine binding specificities of lectins.	Polysaccharides	133-139	CD209 molecule	Homo sapiens	42-93
16713984-6	2006	Moreover, we show that fluorescent beads coated with selected biotinylated glycans bind to DC-SIGN-expressing dendritic cells in vitro.	Polysaccharides	75-82	CD209 molecule	Homo sapiens	91-98
16909868-1	2006	The applicability of terminated oligomerization to the synthesis of oligo-(beta1-6)-glycosamines, fragments of the intercellular polysaccharide adhesin of staphylococci, was studied.	Polysaccharides	129-143	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	75-82
16838281-0	2006	Pharmacokinetics and stability properties of catalase modified with water-soluble polysaccharides.	Polysaccharides	82-97	catalase	Bos taurus	45-53
16766693-7	2006	The rol1 mutations modify the pectic polysaccharide rhamnogalacturonan I and, for one allele, rhamnogalacturonan II.	Polysaccharides	37-51	rhamnose biosynthesis 1	Arabidopsis thaliana	4-8
16819971-2	2006	This study was designed to determine whether the glycans linked at Asn114, Asn199, Asn414 and Asn442 residues of TLR2 ectodomain were involved in the recognition of diacylated lipopeptide and lipoprotein.	Polysaccharides	49-56	toll like receptor 2	Homo sapiens	113-117
16819971-9	2006	These results suggest that the glycan at Asn442 and at least two N-linked glycans speculated to be exposed to the concave surface of TLR2 solenoid are involved in the recognition of ligands by TLR2 and/or in formation or maturation of a functional TLR2 receptor complex.	Polysaccharides	31-37	toll like receptor 2	Homo sapiens	133-137
16819971-9	2006	These results suggest that the glycan at Asn442 and at least two N-linked glycans speculated to be exposed to the concave surface of TLR2 solenoid are involved in the recognition of ligands by TLR2 and/or in formation or maturation of a functional TLR2 receptor complex.	Polysaccharides	31-37	toll like receptor 2	Homo sapiens	193-197
16819971-9	2006	These results suggest that the glycan at Asn442 and at least two N-linked glycans speculated to be exposed to the concave surface of TLR2 solenoid are involved in the recognition of ligands by TLR2 and/or in formation or maturation of a functional TLR2 receptor complex.	Polysaccharides	31-37	toll like receptor 2	Homo sapiens	193-197
16817164-0	2006	Glycoform characterization of erythropoietin combining glycan and intact protein analysis by capillary electrophoresis - electrospray - time-of-flight mass spectrometry.	Polysaccharides	55-61	erythropoietin	Homo sapiens	30-44
16585136-6	2006	The spectra indicate that MUC1F N-glycans have compositions consistent with high-mannose structures (Hex(5-9)HexNAc(2)) and complex/hybrid-type glycans (NeuAc(0-3)Fuc(0-3)Hex(3-8)HexNAc(3-7)).	Polysaccharides	34-41	mucin 1, cell surface associated	Homo sapiens	26-30
16802247-3	2006	Firstly, androgen receptor (AR) and estrogen receptor (ER) protein arrays were prepared on polysaccharide-coated slides to investigate whether they can bind to ASs (affinity tests).	Polysaccharides	91-105	estrogen receptor 1	Homo sapiens	55-57
16817158-7	2006	Fourteen different glycoforms of hCG-alpha, containing biantennary, partly sialylized hybrid-type glycans, including methionine-oxidized and N-terminally truncated forms, were identified.	Polysaccharides	98-105	chromogranin A	Homo sapiens	33-42
16897186-8	2006	In addition, immunohistochemical analysis using sulfated glycan-specific monoclonal antibodies showed that ovarian adenocarcinoma cells express GlcNAc 6-O-sulfated glycans, including an L-selectin ligand and its related glycans.	Polysaccharides	57-63	selectin L	Homo sapiens	186-196
16845109-0	2006	GlyNest and CASPER: two independent approaches to estimate 1H and 13C NMR shifts of glycans available through a common web-interface.	Polysaccharides	84-91	CASP8 and FADD like apoptosis regulator	Homo sapiens	12-18
16845109-1	2006	GlyNest and CASPER (www.casper.organ.su.se/casper/) are two independent services aiming to predict (1)H- and (13)C-NMR chemical shifts of glycans.	Polysaccharides	138-145	CASP8 and FADD like apoptosis regulator	Homo sapiens	12-18
16845109-1	2006	GlyNest and CASPER (www.casper.organ.su.se/casper/) are two independent services aiming to predict (1)H- and (13)C-NMR chemical shifts of glycans.	Polysaccharides	138-145	CASP8 and FADD like apoptosis regulator	Homo sapiens	24-30
16845109-1	2006	GlyNest and CASPER (www.casper.organ.su.se/casper/) are two independent services aiming to predict (1)H- and (13)C-NMR chemical shifts of glycans.	Polysaccharides	138-145	CASP8 and FADD like apoptosis regulator	Homo sapiens	43-49
16766693-9	2006	Thus, the lrx1 mutant phenotype is likely to be suppressed by changes in pectic polysaccharides or other cell wall components.	Polysaccharides	80-95	leucine-rich repeat/extensin 1	Arabidopsis thaliana	10-14
16523522-8	2006	The glycan pattern of isolated samples of EPO was analyzed by weak anion exchange (WAX) HPLC and by normal-phase HPLC incorporating sequential digestion with exoglycosidase arrays.	Polysaccharides	4-10	erythropoietin	Homo sapiens	42-45
16517226-5	2006	On the other hand, the glycopeptide analysis recently developed for site-specific glycans of glycoproteins allows detailed glycan analysis in a high throughput manner and will solve problems in CDG-II diagnosis.	Polysaccharides	82-88	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	194-200
16567801-0	2006	Distinct glycan structures of uroplakins Ia and Ib: structural basis for the selective binding of FimH adhesin to uroplakin Ia.	Polysaccharides	9-15	uroplakin 1A	Homo sapiens	114-126
16595667-9	2006	In addition, vtc4-1 plants incorporate significantly more radiolabel from [2-(3)H]Man into L-galactosyl residues suggesting that the mutation increases the availability of GDP-L-Gal for polysaccharide synthesis.	Polysaccharides	186-200	Inositol monophosphatase family protein	Arabidopsis thaliana	13-17
16720699-6	2006	These mutations locate the dsRNA binding site on the glycan-free, lateral surface of TLR3 toward the C terminus and suggest a model for dsRNA binding and TLR3 activation.	Polysaccharides	53-59	toll like receptor 3	Homo sapiens	85-89
16720699-6	2006	These mutations locate the dsRNA binding site on the glycan-free, lateral surface of TLR3 toward the C terminus and suggest a model for dsRNA binding and TLR3 activation.	Polysaccharides	53-59	toll like receptor 3	Homo sapiens	154-158
16689863-8	2006	Examination of macrophages and T cells from peripheral lymph nodes of control and LNFPIII-treated fsn/fsn mice showed that glycan treatment reduced the numbers of Gr1(+)F4/80(+) macrophages and the numbers of CD8(+) T cells, restoring the numbers of these two cell populations as well as the CD4 : CD8 ratio to near normal levels.	Polysaccharides	123-129	CD4 antigen	Mus musculus	292-295
16540530-4	2006	Among 45 natural glycans tested for lectin binding, galectin-5 reacted best with glycoproteins (gps) presenting a high density of Galbeta1-3/4GlcNAc (I/II) and multiantennary N-glycans with II termini.	Polysaccharides	17-24	galectin 5	Rattus norvegicus	52-62
16701171-3	2006	A low molecular weight fucan (LMWF) compound, a sulfated polysaccharide, has been demonstrated to increase plasma levels of stromal cell-derived factor 1 (SDF-1) and consequently to mobilize bone marrow-derived vascular progenitor cells (BMVPC).	Polysaccharides	57-71	C-X-C motif chemokine ligand 12	Rattus norvegicus	124-153
16701171-3	2006	A low molecular weight fucan (LMWF) compound, a sulfated polysaccharide, has been demonstrated to increase plasma levels of stromal cell-derived factor 1 (SDF-1) and consequently to mobilize bone marrow-derived vascular progenitor cells (BMVPC).	Polysaccharides	57-71	C-X-C motif chemokine ligand 12	Rattus norvegicus	155-160
16730207-5	2006	All these glycans seemed to be attached to the same IGF-II receptor molecules.	Polysaccharides	10-17	insulin like growth factor 2 receptor	Homo sapiens	52-67
16716913-6	2006	The isolated polysaccharide, named CSP-1, which has strong anti-oxidation activity, contains glucose, mannose and galactose in the ratio of 1:0.6:0.75.	Polysaccharides	13-27	common salivary protein 1	Rattus norvegicus	35-40
16841672-7	2006	Caspase-3 expression in hippocampus and medulla could be inhibited by alkaloid, that in hippocampus, cortex and medulla could be inhibited by glycoside and aglycone, and that in hippocampus and medulla by nimodipine, however, polysaccharide showd no effect on it.	Polysaccharides	226-240	caspase 3	Rattus norvegicus	0-9
16841672-9	2006	CONCLUSION: Alkaloid, glycoside, polysaccharide and aglycone from BYHWD could relieve the inflammatory reaction occurred after cerebral ischemia/reperfusion by inhibiting caspase-1 expression to decrease production of inflammatory cytokine.	Polysaccharides	33-47	caspase 1	Rattus norvegicus	171-180
16567801-1	2006	Although it has been shown that mouse uroplakin (UP) Ia, a major glycoprotein of urothelial apical surface, can serve as the receptor for the FimH lectin adhesin of type 1-fimbriated Escherichia coli, the organism that causes a great majority of urinary tract infections, the glycan structure of this native receptor was unknown.	Polysaccharides	276-282	uroplakin 1A	Mus musculus	38-55
16567801-5	2006	In contrast, our results indicate that most terminally exposed glycans of mouse UPIb are non-mannose residues, thus explaining the failure of FimH to bind to this UPIb.	Polysaccharides	63-70	uroplakin 1B	Mus musculus	80-84
16543244-2	2006	SC displays numerous and various glycans, which are potential ligands for bacterial compounds.	Polysaccharides	33-40	fucosyltransferase 1 (H blood group)	Homo sapiens	0-2
16704275-1	2006	The major structural component of the cell wall of Mycobacterium tuberculosis is a lipidated polysaccharide, the mycoyl-arabinogalactan-peptidoglycan (mAGP) complex.	Polysaccharides	93-107	microfibrillar-associated protein 2	Mus musculus	151-155
16543244-5	2006	The interaction is mediated by glycans present on hSC and involves galactose and sialic acid residues.	Polysaccharides	31-38	fucosyltransferase 1 (H blood group)	Homo sapiens	50-53
16791723-3	2006	To further investigate the possibility to utilize the modified protein for tissue engineering application, TGase crosslinked gelatine was incorporated in a gellan matrix, a polysaccharide, to enhance the stability in aqueous media.	Polysaccharides	173-187	transglutaminase 1	Homo sapiens	107-112
19127725-0	2006	Alkali-soluble polysaccharides of Rhizoclonium riparium alga induce IL-1 gene expression via protein kinase signaling pathways.	Polysaccharides	15-30	interleukin 1 complex	Mus musculus	68-72
19127725-4	2006	Using a murine-derived macrophage cell line J774A.1, we found that polysaccharide constituents of the higher molecular-weight group of RASP were able to induce interleukin-1beta (IL-1) gene expression via protein kinase-mediated signal transduction pathways.	Polysaccharides	67-81	interleukin 1 beta	Mus musculus	160-177
19127725-4	2006	Using a murine-derived macrophage cell line J774A.1, we found that polysaccharide constituents of the higher molecular-weight group of RASP were able to induce interleukin-1beta (IL-1) gene expression via protein kinase-mediated signal transduction pathways.	Polysaccharides	67-81	interleukin 1 complex	Mus musculus	179-183
19127725-6	2006	To the best of our knowledge, this is the first occasion that polysaccharides from R. riparium have been demonstrated to exert immunomodulation properties by the induction of IL-1 within macrophages.	Polysaccharides	62-77	interleukin 1 complex	Mus musculus	175-179
16650003-5	2006	Nanoscale LC-MS(/MS) and MALDI-TOF(/TOF)-MS studies combined with enzymatic degradations showed that monomeric IPSE/alpha-1 contains two N-glycosylation sites, which are each occupied for a large proportion with core-difucosylated diantennary glycans that carry one or more Lewis X motifs.	Polysaccharides	243-250	adrenoceptor alpha 1D	Homo sapiens	116-123
16711753-3	2006	Several studies have been performed to elucidate the mechanism of the anti-HIV-1 activity of sulfated polysaccharides and polyanions in general, including binding to cell surface CD4 and interfering with the gp120-coreceptor interaction.	Polysaccharides	102-117	CD4 molecule	Homo sapiens	179-182
16423983-7	2006	The Dectin-2 CRD exhibited only weak interactions to some of these capsular polysaccharides, indicative of different structural or affinity requirements for binding, when compared with the other two lectins.	Polysaccharides	76-91	C-type lectin domain containing 6A	Homo sapiens	4-12
16423983-8	2006	Glycan array analysis of the carbohydrate recognition by Dectin-2 indicated specific recognition of high-mannose structures (Man(9)GlcNAc(2)).	Polysaccharides	0-6	C-type lectin domain containing 6A	Homo sapiens	57-65
16711753-3	2006	Several studies have been performed to elucidate the mechanism of the anti-HIV-1 activity of sulfated polysaccharides and polyanions in general, including binding to cell surface CD4 and interfering with the gp120-coreceptor interaction.	Polysaccharides	102-117	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	208-213
16823913-0	2006	Novel human polysaccharide adjuvants with dual Th1 and Th2 potentiating activity.	Polysaccharides	12-26	negative elongation factor complex member C/D	Homo sapiens	47-50
16524638-0	2006	New loading process and release properties of insulin from polysaccharide microcapsules fabricated through layer-by-layer assembly.	Polysaccharides	59-73	insulin	Homo sapiens	46-53
16689758-8	2006	CONCLUSIONS: Modification of glycosylation in the variable region of antibodies contributes to the diversity of FVIII type II inhibition possibly by steric hindrance of the active site of FVIII by glycans, and may provide a novel strategy to modulate the functional activity of therapeutic antibodies.	Polysaccharides	197-204	coagulation factor VIII	Mus musculus	112-117
16689758-8	2006	CONCLUSIONS: Modification of glycosylation in the variable region of antibodies contributes to the diversity of FVIII type II inhibition possibly by steric hindrance of the active site of FVIII by glycans, and may provide a novel strategy to modulate the functional activity of therapeutic antibodies.	Polysaccharides	197-204	coagulation factor VIII	Mus musculus	188-193
16619023-4	2006	Though many glycoproteins can carry the glycan structure recognized by the GBP, other factors, such as recognition of protein epitopes and microdomain localization, may restrict which glycoproteins are functional ligands in situ.	Polysaccharides	40-46	transmembrane protein 132A	Homo sapiens	75-78
16619023-5	2006	Recent advances in development of glycan arrays, synthesis of multivalent glycan ligands, bioengineering of cell-surface glycans and glycomics databases are providing new tools to identify the ligands of GBPs and to elucidate the mechanisms by which they participate in GBP function.	Polysaccharides	34-40	transmembrane protein 132A	Homo sapiens	204-207
16619023-5	2006	Recent advances in development of glycan arrays, synthesis of multivalent glycan ligands, bioengineering of cell-surface glycans and glycomics databases are providing new tools to identify the ligands of GBPs and to elucidate the mechanisms by which they participate in GBP function.	Polysaccharides	74-80	transmembrane protein 132A	Homo sapiens	204-207
16619023-5	2006	Recent advances in development of glycan arrays, synthesis of multivalent glycan ligands, bioengineering of cell-surface glycans and glycomics databases are providing new tools to identify the ligands of GBPs and to elucidate the mechanisms by which they participate in GBP function.	Polysaccharides	121-128	transmembrane protein 132A	Homo sapiens	204-207
16439369-9	2006	Furthermore, the CRD of Emp46p binds to glycoproteins carrying high mannosetype glycans and the is promoted by binding not the addition of Ca(2+) or K(+) ion in These results suggest that Emp46p can be regarded as a Ca(2+)-independent intracellular lectin at the ER exit sites.	Polysaccharides	80-87	Emp46p	Saccharomyces cerevisiae S288C	24-30
16439369-9	2006	Furthermore, the CRD of Emp46p binds to glycoproteins carrying high mannosetype glycans and the is promoted by binding not the addition of Ca(2+) or K(+) ion in These results suggest that Emp46p can be regarded as a Ca(2+)-independent intracellular lectin at the ER exit sites.	Polysaccharides	80-87	Emp46p	Saccharomyces cerevisiae S288C	188-194
23427436-1	2006	The capacity of the 4B3 monoclonal antibody, previously obtained by immunization of BALB/c mice with the capsular polysaccharide of Cryptococcus neoformans was studied to recognize this structure as part of the intact cell of this yeast.	Polysaccharides	114-128	TBC1 domain family, member 31	Mus musculus	20-23
16679745-1	2006	The effects of polysaccharide extracted from Lycium barbarum (LBP) on blood glucose, oxidative stress and DNA damage in rats with non-insulin dependent diabetes mellitus (NIDDM) were studied.	Polysaccharides	15-29	lipopolysaccharide binding protein	Rattus norvegicus	62-65
16442510-3	2006	The analysis of the experimental data, using our previously described kinetic model [Biomaterials1997, 18, 203] (i) suggested that both DSS1 and DSS2 catalyzed the thrombin-AT reaction according to a mechanism in which the oversulfated derivative quickly formed with AT a complex, which was more reactive towards thrombin than the free inhibitor and (ii) allowed us to determine the dissociation constants of the polysaccharide-inhibitor complexes, which were (1.15 +/- 0.74) x 10(-7) and (7.17 +/- 0.65) x 10(-9) M, and the catalyzed reaction rate constants, which were (2.29 +/- 0.15) x 10(8) and (8.71 +/- 0.08) x 10(8) M(-1) min(-1), for DSS1 and DSS2, respectively.	Polysaccharides	413-427	SEM1 26S proteasome subunit	Homo sapiens	136-140
16442510-3	2006	The analysis of the experimental data, using our previously described kinetic model [Biomaterials1997, 18, 203] (i) suggested that both DSS1 and DSS2 catalyzed the thrombin-AT reaction according to a mechanism in which the oversulfated derivative quickly formed with AT a complex, which was more reactive towards thrombin than the free inhibitor and (ii) allowed us to determine the dissociation constants of the polysaccharide-inhibitor complexes, which were (1.15 +/- 0.74) x 10(-7) and (7.17 +/- 0.65) x 10(-9) M, and the catalyzed reaction rate constants, which were (2.29 +/- 0.15) x 10(8) and (8.71 +/- 0.08) x 10(8) M(-1) min(-1), for DSS1 and DSS2, respectively.	Polysaccharides	413-427	coagulation factor II, thrombin	Homo sapiens	164-172
16823931-1	2006	We evaluated the adjuvant properties and toxicity of purified Neisseria meningitidis serogroup B lipopolysaccharide (LPS) conjugated with tetanus toxoid (TT) using a new method of conjugation to obtain amine groups in the polysaccharide structure.	Polysaccharides	101-115	toll-like receptor 4	Mus musculus	117-120
16615889-4	2006	To better understand the mechanisms involved, we studied SIGN-R1, a lectin that captures microbial polysaccharides in spleen.	Polysaccharides	99-114	CD209b antigen	Mus musculus	57-64
16483609-2	2006	1,3-1,4-beta-Glucanases selectively cleave beta-1,4 glycosidic bonds in 3-O-substituted glucopyranosyl units within polysaccharides with mixed linkage.	Polysaccharides	116-131	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	43-51
16615889-5	2006	Surprisingly, conditional SIGN-R1 knockout mice developed deficits in C3 catabolism when given S. pneumoniae or its capsular polysaccharide intravenously.	Polysaccharides	125-139	CD209b antigen	Mus musculus	26-33
16552049-0	2006	Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide.	Polysaccharides	137-151	interleukin 17A	Mus musculus	22-37
16614890-0	2006	A polysaccharide isolated from the medicinal herb Bletilla striata induces endothelial cells proliferation and vascular endothelial growth factor expression in vitro.	Polysaccharides	2-16	vascular endothelial growth factor A	Homo sapiens	111-145
16460731-9	2006	These findings indicate that BDNF/TrkB signaling is important for functional recovery after nerve repair and suggest that up-regulation of the HNK-1 glycan is linked to this phenomenon.	Polysaccharides	149-155	brain derived neurotrophic factor	Mus musculus	29-33
16460731-9	2006	These findings indicate that BDNF/TrkB signaling is important for functional recovery after nerve repair and suggest that up-regulation of the HNK-1 glycan is linked to this phenomenon.	Polysaccharides	149-155	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	34-38
16460731-9	2006	These findings indicate that BDNF/TrkB signaling is important for functional recovery after nerve repair and suggest that up-regulation of the HNK-1 glycan is linked to this phenomenon.	Polysaccharides	149-155	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	143-148
16217746-2	2006	Heparanase is the predominant enzyme involved in cleavage of heparan sulfate, the main polysaccharide component of the extracellular matrix.	Polysaccharides	87-101	heparanase	Homo sapiens	0-10
16549682-5	2006	Lon protease of A. tumefaciens shares high homology with its counterparts in E. coli and in Sinorhizobium meliloti, and functionally complements an E. coli lon mutant for defects in morphology and RcsA-mediated regulation of capsular polysaccharide production.	Polysaccharides	234-248	endopeptidase La	Agrobacterium fabrum str. C58	0-3
16571816-9	2006	Furthermore, inoculation of pigs with the mutant viruses induced significantly higher levels of neutralizing antibodies against the mutant as well as the wt PRRSV, suggesting that the loss of glycan residues in the ectodomain of GP5 enhances both the sensitivity of these viruses to in vitro neutralization and the immunogenicity of the nearby neutralization epitope.	Polysaccharides	192-198	glycoprotein V platelet	Homo sapiens	229-232
16288808-1	2006	Ricinus communis agglutinin (RCA1) is one of the most important applied lectins that has been widely used as a tool to study cell surfaces and to purify glycans.	Polysaccharides	153-160	von Hippel-Lindau tumor suppressor	Homo sapiens	29-33
16288808-3	2006	Here, all possible recognition factors of RCA1 of glycan binding were examined by enzyme-linked lectinosorbent (ELLSA) and inhibition assays, using known mammalian Gal/GalNAc carbohydrate structural units and natural polyvalent glycans.	Polysaccharides	50-56	von Hippel-Lindau tumor suppressor	Homo sapiens	42-46
16288808-3	2006	Here, all possible recognition factors of RCA1 of glycan binding were examined by enzyme-linked lectinosorbent (ELLSA) and inhibition assays, using known mammalian Gal/GalNAc carbohydrate structural units and natural polyvalent glycans.	Polysaccharides	228-235	von Hippel-Lindau tumor suppressor	Homo sapiens	42-46
16584311-6	2006	These results suggest that enzymatic breakdown of complex polysaccharides such as mucin by members of the indigenous microbiota may provide a source of nutritional support for VRE.	Polysaccharides	58-73	mucin 1, cell surface associated	Bos taurus	82-87
16581792-6	2006	Antibodies to the galectin-3 N-terminal oligomerization domain stimulate alpha5beta1 activation and recruitment to fibrillar adhesions in Mgat5(+/+) cells, an effect that is blocked by disrupting galectin-glycan binding.	Polysaccharides	205-211	galectin 3	Homo sapiens	18-28
16549682-5	2006	Lon protease of A. tumefaciens shares high homology with its counterparts in E. coli and in Sinorhizobium meliloti, and functionally complements an E. coli lon mutant for defects in morphology and RcsA-mediated regulation of capsular polysaccharide production.	Polysaccharides	234-248	putative ATP-dependent Lon protease	Escherichia coli	156-159
16581792-6	2006	Antibodies to the galectin-3 N-terminal oligomerization domain stimulate alpha5beta1 activation and recruitment to fibrillar adhesions in Mgat5(+/+) cells, an effect that is blocked by disrupting galectin-glycan binding.	Polysaccharides	205-211	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	138-143
16517274-11	2006	INTERPRETATION: These results confirm that using the H influenzae-derived protein D as a carrier protein for pneumococcal polysaccharides not only allowed protection against pneumococcal otitis, but also against acute otitis media due to non-typable H influenzae.	Polysaccharides	122-137	dehydrogenase/reductase 2	Homo sapiens	74-83
16500990-12	2006	These findings demonstrate that the reb1-1 mutation affects XyG structure, but not that of pectic polysaccharides, thus lending support to the hypothesis that biosynthesis of Gal as well as galactosylation of complex polysaccharides is regulated at the polymer level.	Polysaccharides	217-232	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	36-42
16414019-4	2006	We biochemically characterized two PrP-related proteins from zebrafish in cultured cells and show that both zePrP1 and zeSho2 are imported into the endoplasmic reticulum and are post-translationally modified with complex glycans and a C-terminal GPI anchor.	Polysaccharides	221-228	prion protein	Homo sapiens	35-38
16532012-2	2006	In biosynthesis of heparan sulfate (HS), a structurally related polysaccharide, HS glucuronyl C5-epimerase (Hsepi) converts D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) residues.	Polysaccharides	64-78	glucuronyl C5-epimerase	Mus musculus	80-106
16532012-2	2006	In biosynthesis of heparan sulfate (HS), a structurally related polysaccharide, HS glucuronyl C5-epimerase (Hsepi) converts D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) residues.	Polysaccharides	64-78	glucuronyl C5-epimerase	Mus musculus	108-113
16407218-1	2006	The serum collectin mannan-binding lectin (MBL) binds to oligomannose and GlcNAc-terminating glycans present on microorganisms.	Polysaccharides	93-100	mannose binding lectin 2	Homo sapiens	43-46
16198015-1	2006	Complex glycoprotein biopharmaceuticals, such as follicle stimulating hormone (FSH), erythropoietin and tissue plasminogen activator consist of a range of charge isoforms due to the extent of sialic acid capping of the glycoprotein glycans.	Polysaccharides	232-239	erythropoietin	Homo sapiens	85-99
16198015-1	2006	Complex glycoprotein biopharmaceuticals, such as follicle stimulating hormone (FSH), erythropoietin and tissue plasminogen activator consist of a range of charge isoforms due to the extent of sialic acid capping of the glycoprotein glycans.	Polysaccharides	232-239	chromosome 20 open reading frame 181	Homo sapiens	104-132
17177794-0	2006	Synthesis of enzymatically active human alpha-L-iduronidase in Arabidopsis cgl (complex glycan-deficient) seeds.	Polysaccharides	88-94	alpha-L-iduronidase	Homo sapiens	40-59
16282604-4	2006	Since Lex residues of pathogens bind to the C-type lectin dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) expressed on human DCs, we hypothesized that Lex glycans of CEACAM1 are recognized by DC-SIGN.	Polysaccharides	169-176	fucosyltransferase 4	Homo sapiens	6-9
16282604-4	2006	Since Lex residues of pathogens bind to the C-type lectin dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) expressed on human DCs, we hypothesized that Lex glycans of CEACAM1 are recognized by DC-SIGN.	Polysaccharides	169-176	fucosyltransferase 4	Homo sapiens	165-168
16282604-4	2006	Since Lex residues of pathogens bind to the C-type lectin dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) expressed on human DCs, we hypothesized that Lex glycans of CEACAM1 are recognized by DC-SIGN.	Polysaccharides	169-176	CEA cell adhesion molecule 1	Homo sapiens	180-187
16319081-5	2006	This review will focus on the involvement of the glycans in glycodelin activity and compare between the several glycoforms.	Polysaccharides	49-56	progestagen associated endometrial protein	Homo sapiens	60-70
16476981-4	2006	The V3 loop glycan had a sensitivity of 0.98 and a 0.92 positive predictive value in the context of CCR5 use.	Polysaccharides	12-18	C-C motif chemokine receptor 5	Homo sapiens	100-104
16476981-7	2006	The results suggest a close association between the V3 loop glycan and CCR5 use and may provide new insight into HIV-1 tropism and help to improve phenotype-prediction models.	Polysaccharides	60-66	C-C motif chemokine receptor 5	Homo sapiens	71-75
17177794-6	2006	Affinity-purified IDUA derived from cgl mutant seeds showed a markedly reduced reaction with the antibody specific for plant complex glycans, despite transit of the protein to the apoplast.	Polysaccharides	133-140	alpha-L-iduronidase	Homo sapiens	18-22
17177794-8	2006	The combined results indicate that IDUA produced in cgl mutant seeds contains glycans primarily in the high-mannose form.	Polysaccharides	78-85	alpha-L-iduronidase	Homo sapiens	35-39
16290306-8	2006	In particular the monomeric form of the enzyme provides a valuable tool for structural analyses to elucidate the fine specifity of fucosyltransferase V-mediated fucosylation of Lewis type glycans.	Polysaccharides	188-195	fucosyltransferase 5	Homo sapiens	131-151
16716920-3	2006	The major glycan structures of the antibodies produced by transgenic suspension-cultured cells contain typical plant bisecting beta(1,2)-xylose and alpha(1,3)-fucose residues, suggesting the posttranslational modification of a recombinant antibody in the late Golgi apparatus.	Polysaccharides	10-16	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	127-135
16716920-3	2006	The major glycan structures of the antibodies produced by transgenic suspension-cultured cells contain typical plant bisecting beta(1,2)-xylose and alpha(1,3)-fucose residues, suggesting the posttranslational modification of a recombinant antibody in the late Golgi apparatus.	Polysaccharides	10-16	adrenoceptor alpha 1D	Homo sapiens	148-157
16183225-1	2006	We demonstrate that polysaccharides isolated from Salicornia herbacea (Salicornia polysaccharides, SPS) significantly induces nitric oxide (NO) production and inducible NO synthase (iNOS) transcription through the activation of nuclear factor-kappaB/Rel (NF-kappaB/Rel).	Polysaccharides	20-35	nitric oxide synthase 2, inducible	Mus musculus	182-186
16183225-1	2006	We demonstrate that polysaccharides isolated from Salicornia herbacea (Salicornia polysaccharides, SPS) significantly induces nitric oxide (NO) production and inducible NO synthase (iNOS) transcription through the activation of nuclear factor-kappaB/Rel (NF-kappaB/Rel).	Polysaccharides	20-35	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	255-264
16441437-0	2006	Cryptococcus neoformans capsular polysaccharide component galactoxylomannan induces apoptosis of human T-cells through activation of caspase-8.	Polysaccharides	33-47	caspase 8	Homo sapiens	133-142
16337930-7	2006	Mapping the glycans onto the crystal structure of SBP shows that these are asymmetrically distributed on the molecule, occurring primarily on the substrate-channel face of the enzyme.	Polysaccharides	12-19	sucrose-binding protein 2	Glycine max	50-53
16415006-1	2006	The C-type lectins DC-SIGN and DC-SIGNR bind mannose-rich glycans with high affinity.	Polysaccharides	58-65	C-type lectin domain family 4 member M	Homo sapiens	31-39
16177264-0	2006	Different glycan structures in prostate-specific antigen from prostate cancer sera in relation to seminal plasma PSA.	Polysaccharides	10-16	kallikrein related peptidase 3	Homo sapiens	113-116
16177264-4	2006	We therefore undertook a detailed glycan analysis of PSA derived from sera from PCa patients and, importantly, established that the glycosylation of the PCa serum PSA was significantly different from the PSA from the LNCaP cell line.	Polysaccharides	34-40	kallikrein related peptidase 3	Homo sapiens	163-166
16177264-4	2006	We therefore undertook a detailed glycan analysis of PSA derived from sera from PCa patients and, importantly, established that the glycosylation of the PCa serum PSA was significantly different from the PSA from the LNCaP cell line.	Polysaccharides	34-40	kallikrein related peptidase 3	Homo sapiens	163-166
16457596-5	2006	We show here that increased levels of core fucosylation can be observed via glycan analysis of total serum and are associated with the development of HCC.	Polysaccharides	76-82	HCC	Homo sapiens	150-153
16385627-1	2006	Immunization with a tetanus-protein (TT) pneumococcal polysaccharide (PPS) conjugate vaccine (Pnc1-TT) induces protective immunity against lethal pneumococcal infections in neonatal and infant mice, but anti-PPS IgG response and protective efficacy is lower than in adult mice.	Polysaccharides	54-68	solute carrier family 25 member 33	Homo sapiens	94-98
16428732-8	2006	The polysaccharide of NP1-MC exhibits a thicker capsule, and thus NP1-MC exhibits enhanced intracellular survival in macrophages.	Polysaccharides	4-18	neuronal pentraxin 1	Mus musculus	22-25
16428732-8	2006	The polysaccharide of NP1-MC exhibits a thicker capsule, and thus NP1-MC exhibits enhanced intracellular survival in macrophages.	Polysaccharides	4-18	neuronal pentraxin 1	Mus musculus	66-69
16428732-10	2006	In contrast, the thin polysaccharide capsule of NP1-SM permits better crossing of the blood-brain barrier.	Polysaccharides	22-36	neuronal pentraxin 1	Mus musculus	48-51
16369536-1	2006	CD22 is a negative regulator of B cell signaling, an activity modulated by its interaction with glycan ligands containing alpha2-6-linked sialic acids.	Polysaccharides	96-102	CD22 antigen	Mus musculus	0-4
16493483-0	2006	Modulation of protease nexin-1 activity by polysaccharides.	Polysaccharides	43-58	serpin family E member 2	Homo sapiens	14-30
16493483-5	2006	Using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) and affinity coelectrophoresis, we observed that polysaccharides bound to thrombin, PN-1 and the thrombin/PN-1 complex.	Polysaccharides	148-163	coagulation factor II, thrombin	Homo sapiens	173-181
16493483-5	2006	Using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) and affinity coelectrophoresis, we observed that polysaccharides bound to thrombin, PN-1 and the thrombin/PN-1 complex.	Polysaccharides	148-163	coagulation factor II, thrombin	Homo sapiens	196-204
16493483-5	2006	Using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) and affinity coelectrophoresis, we observed that polysaccharides bound to thrombin, PN-1 and the thrombin/PN-1 complex.	Polysaccharides	148-163	serpin family E member 2	Homo sapiens	205-209
16493483-8	2006	The dose response followed a bell shape curve, again suggesting the formation of ternary complexes between thrombin, PN-1 and polysaccharides.	Polysaccharides	126-141	coagulation factor II, thrombin	Homo sapiens	107-115
16493483-9	2006	We also investigated the ability of polysaccharides to remove PN-1 bound to the cell membrane of smooth muscle cells in culture.	Polysaccharides	36-51	serpin family E member 2	Homo sapiens	62-66
16105692-1	2006	Previous studies have demonstrated that the covalent modification of target protein and polysaccharide antigens with the activated complement product C3d results in dramatically enhanced immunogenicity of the target antigens.	Polysaccharides	88-102	endogenous retrovirus group K member 13	Homo sapiens	150-153
16407137-4	2006	This mutant phenotype is the first found for an N-acetylmuramoyl-l-alanine amidase PGRP that cleaves peptidoglycan at the lactylamide bond between the glycan backbone and the crosslinking stem peptides.	Polysaccharides	108-114	Peptidoglycan recognition protein LE	Drosophila melanogaster	83-87
16310167-5	2006	Surface plasmon resonance was used to measure the interaction of each member of this polysaccharide library with antithrombin III (ATIII), to afford structural information on sulfo groups required for this HP/HS-protein interaction.	Polysaccharides	85-99	serpin family C member 1	Homo sapiens	113-129
16310167-5	2006	Surface plasmon resonance was used to measure the interaction of each member of this polysaccharide library with antithrombin III (ATIII), to afford structural information on sulfo groups required for this HP/HS-protein interaction.	Polysaccharides	85-99	serpin family C member 1	Homo sapiens	131-136
16684673-1	2006	A pectic polysaccharide, lemnan LMC, was extracted from the callus of duckweed Lemna minor L. and was tested for adjuvant properties at oral administration with protein antigen.	Polysaccharides	9-23	chemokine (C-C motif) ligand 16, pseudogene	Mus musculus	32-35
17196015-1	2006	Bacterial endotoxin, fungal (1 --&gt; 3)-beta-D-glucans, and extracellular polysaccharides from Aspergillus and Penicillium (EPS-Asp/Pen) have been suggested to be stable markers of microbial exposure.	Polysaccharides	75-90	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	112-115
17304538-3	2006	For example, calnexin and calreticulin (CRT) are molecular chaperones that recognize monoglucosylated forms of high-mannose-type glycans.	Polysaccharides	129-136	calnexin	Homo sapiens	13-21
17304538-3	2006	For example, calnexin and calreticulin (CRT) are molecular chaperones that recognize monoglucosylated forms of high-mannose-type glycans.	Polysaccharides	129-136	calreticulin	Homo sapiens	26-38
17304538-3	2006	For example, calnexin and calreticulin (CRT) are molecular chaperones that recognize monoglucosylated forms of high-mannose-type glycans.	Polysaccharides	129-136	calreticulin	Homo sapiens	40-43
16958607-7	2006	The glycans of seminal plasma fibronectin, in contrast to blood plasma fibronectin, contained sialic acid more frequently attached by alpha2,3 than by alpha2,6 isomeric linkage.	Polysaccharides	4-11	fibronectin 1	Homo sapiens	30-41
16150464-0	2006	Antioxidant properties and PC12 cell protective effects of APS-1, a polysaccharide from Aloe vera var.	Polysaccharides	68-82	autoimmune regulator	Homo sapiens	59-64
16097953-0	2006	Biotinylation of glycan chains in beta2 glycoprotein I induces dimerization of the molecule and its detection by the human autoimmune anti-cardiolipin antibody EY2C9.	Polysaccharides	17-23	apolipoprotein H	Homo sapiens	34-54
16097953-2	2006	We recently showed that binding of beta2GPI to AnPLs was enhanced by biotinylation of its glycan chains with biotin-hydrazide.	Polysaccharides	90-96	apolipoprotein H	Homo sapiens	35-43
16467879-12	2006	These results supported the mechanism that blocking of GnT-V expression impaired functions of chaperones and N-glycan-synthesizing enzymes, which caused UPR in vivo.	Polysaccharides	111-117	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	55-60
16080149-8	2006	Induction of an inflamed phenotype of the cells by treatment with TNFalpha differentially modulates a set of these genes in HUVEC and FMVEC resulting in a change in the cell membrane associated glycans that are of importance in inflammation-related endothelial cell-surface processes.	Polysaccharides	194-201	tumor necrosis factor	Homo sapiens	66-74
16800153-1	2006	Novel partially biodegradable, temperature- and pH-sensitive polysaccharide-based hydrogels (NDF) were synthesized from modified dextran (dextran-maleic acid, Dex-MA) and N-isopropylacrylamide precursors over a wide range of mixed solvent ratios of dimethyl formamide (DMF) to water.	Polysaccharides	61-75	neuregulin 1	Homo sapiens	93-96
16365447-0	2006	CD4+ T lymphocytes expressing CD40 ligand help the IgM antibody response to soluble pneumococcal polysaccharides via an intermediate cell type.	Polysaccharides	97-112	CD4 antigen	Mus musculus	0-3
16365447-0	2006	CD4+ T lymphocytes expressing CD40 ligand help the IgM antibody response to soluble pneumococcal polysaccharides via an intermediate cell type.	Polysaccharides	97-112	CD40 antigen	Mus musculus	30-34
17132495-2	2006	Among these carbohydrates, polysialic acid is a unique glycan that modulates functions of the neural cell adhesion molecule (NCAM) by attenuating NCAM-mediated interaction between neural cells.	Polysaccharides	55-61	neural cell adhesion molecule 1	Mus musculus	94-123
16379001-9	2006	Molecular modeling of the 89.6P sequence showed that the conserved glycans lie on the silent face of Env and that many are proximal to disulfide bonds, while PNG additions and shifts are proximal to the CD4 binding site.	Polysaccharides	67-74	endogenous retrovirus group W member 1, envelope	Homo sapiens	101-104
16379001-11	2006	This longitudinal and cross-sectional study of mutations in human immunodeficiency virus (HIV) env in the SHIV background provides evidence that there are more constraints on the configuration of the glycan shield than were previously appreciated.	Polysaccharides	200-206	endogenous retrovirus group W member 1, envelope	Homo sapiens	95-98
17113873-0	2006	Functions of glycans revealed by gene inactivation of L-selectin ligand sulfotransferases in mice.	Polysaccharides	13-20	selectin, lymphocyte	Mus musculus	54-64
17132495-2	2006	Among these carbohydrates, polysialic acid is a unique glycan that modulates functions of the neural cell adhesion molecule (NCAM) by attenuating NCAM-mediated interaction between neural cells.	Polysaccharides	55-61	neural cell adhesion molecule 1	Mus musculus	125-129
17132495-2	2006	Among these carbohydrates, polysialic acid is a unique glycan that modulates functions of the neural cell adhesion molecule (NCAM) by attenuating NCAM-mediated interaction between neural cells.	Polysaccharides	55-61	neural cell adhesion molecule 1	Mus musculus	146-150
16855347-4	2006	Unusual immunologic features of HIT, such as the dissociation between immunogenicity (induction of immune response) and cross-reactivity (capacity to form the antigens recognized by HIT antibodies)of the implicated polysaccharide anticoagulants, and the generally rapid formation and disappearance of anti-PF4/heparin antibodies, suggest that further lessons regarding HIT immunopathogenesis remain to be learned.	Polysaccharides	215-229	platelet factor 4	Homo sapiens	306-309
16369184-0	2006	Protective effect of a protein-bound polysaccharide, PSK, on CLP-induced sepsis in mice transplanted orthotopically with colon tumor.	Polysaccharides	37-51	TAO kinase 2	Mus musculus	53-56
16377570-3	2005	Loss of GlcNAcT-IVa, or the addition of glycan-ligand mimetics, attenuates Glut-2 cell-surface half-life, provoking endocytosis with redistribution into endosomes and lysosomes.	Polysaccharides	40-46	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	75-81
16230337-10	2005	Hence, the N-glycans linked to the beta2 subunit of the Na,K-ATPase contain apical sorting information, and the high abundance of the beta2 subunit isoform, which is rich in N-glycans, along with the absence of the beta1 subunit, is responsible for the unusual apical location of the Na,K-ATPase in HGT-1 cells.	Polysaccharides	13-20	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	35-40
16343610-1	2005	A purified polysaccharide ACDP-2 was isolated from water extract of the stems of Cistanche deserticola.	Polysaccharides	11-25	cyclin M2	Mus musculus	26-32
16351786-1	2005	BACKGROUND &amp; OBJECTIVE: Heparanase (Hpa) is an endoglycosidase that degrades heparin sulfate--the main polysaccharide constituent of extracellular matrix (ECM) and basement.	Polysaccharides	107-121	heparanase	Homo sapiens	28-38
16378103-11	2005	These two kinds of polysaccharide could significantly increase the secretion of IL-2 and IFN-gamma in doublejway MLR at the concentrations of 0.2-12.8 mg/L, but Gl-BSP had stronger effects than Gl-SP at the same concentrations.	Polysaccharides	19-33	interleukin 2	Mus musculus	80-84
16378103-11	2005	These two kinds of polysaccharide could significantly increase the secretion of IL-2 and IFN-gamma in doublejway MLR at the concentrations of 0.2-12.8 mg/L, but Gl-BSP had stronger effects than Gl-SP at the same concentrations.	Polysaccharides	19-33	interferon gamma	Mus musculus	89-98
16289063-4	2005	Based on these studies, coordinated modulation of the sialic acid contents, state of subunit assembly and number of glycans allowed us to generate human or bovine AChE forms which reside in the circulation of mice for long periods of time, mimicking the pharmacokinetic behavior of native serum-derived cholinesterases.	Polysaccharides	116-123	acetylcholinesterase	Bos taurus	163-167
16351786-1	2005	BACKGROUND &amp; OBJECTIVE: Heparanase (Hpa) is an endoglycosidase that degrades heparin sulfate--the main polysaccharide constituent of extracellular matrix (ECM) and basement.	Polysaccharides	107-121	heparanase	Homo sapiens	40-43
16297170-7	2005	Biotinylated lectins were used in an enzyme-linked immunosorbent assay (ELISA) to examine different glycans on IgA1 molecules.	Polysaccharides	100-107	immunoglobulin heavy constant alpha 1	Homo sapiens	111-115
16109780-8	2005	At high concentrations, however, fondaparinux inhibited binding of HIT antibodies to PF4/polysaccharide, indicating that PF4/fondaparinux interactions occur.	Polysaccharides	89-103	platelet factor 4	Homo sapiens	121-124
16263905-0	2005	Biochemical and immunohistochemical analysis of pectic polysaccharides in the cell walls of Arabidopsis mutant QUASIMODO 1 suspension-cultured cells: implications for cell adhesion.	Polysaccharides	55-70	Nucleotide-diphospho-sugar transferases superfamily protein	Arabidopsis thaliana	111-122
16037488-3	2005	Here we show that in untreated galactosemia, there is also a partial deficiency of whole glycans of serum transferrin associated with increased fucosylation and branching as seen in genetic glycosylation assembly defects (CDG-I).	Polysaccharides	89-96	transferrin	Homo sapiens	106-117
16521710-0	2005	Sulfated polysaccharides derived from dietary seaweeds increase the esterase activity of a lymphocyte tryptase, granzyme A.	Polysaccharides	9-24	tryptase alpha/beta 1	Rattus norvegicus	102-110
16521710-0	2005	Sulfated polysaccharides derived from dietary seaweeds increase the esterase activity of a lymphocyte tryptase, granzyme A.	Polysaccharides	9-24	granzyme A	Rattus norvegicus	112-122
16521710-3	2005	In the present study, we examined the effect of sulfated polysaccharides from seaweeds on esterase activity of a lymphocyte tryptase, granzyme A (GzmA), which is believed to induce the production of cytokines in a variety of cells.	Polysaccharides	57-72	tryptase alpha/beta 1	Rattus norvegicus	124-132
16521710-3	2005	In the present study, we examined the effect of sulfated polysaccharides from seaweeds on esterase activity of a lymphocyte tryptase, granzyme A (GzmA), which is believed to induce the production of cytokines in a variety of cells.	Polysaccharides	57-72	granzyme A	Rattus norvegicus	134-144
16521710-3	2005	In the present study, we examined the effect of sulfated polysaccharides from seaweeds on esterase activity of a lymphocyte tryptase, granzyme A (GzmA), which is believed to induce the production of cytokines in a variety of cells.	Polysaccharides	57-72	granzyme A	Rattus norvegicus	146-150
16521710-8	2005	In the present paper, we propose that the enhancement of immune responses by intake of the sulfated polysaccharides from seaweeds can be partially accounted for by their direct effects on GzmA.	Polysaccharides	100-115	granzyme A	Rattus norvegicus	188-192
16494031-4	2005	RESULT: Compared with the control group, the levels of EGF, TGF-alpha, IL-1beta, IL-6 and IL-8 were significantly increased by treatment with Aloe coarse polysaccharide (P &lt; 0.05, P &lt; 0.01) and in a dose dependent manner, and the levels of TGF-beta1 and TNF were also increased but no statistical significance.	Polysaccharides	154-168	transforming growth factor alpha	Homo sapiens	60-69
16494031-4	2005	RESULT: Compared with the control group, the levels of EGF, TGF-alpha, IL-1beta, IL-6 and IL-8 were significantly increased by treatment with Aloe coarse polysaccharide (P &lt; 0.05, P &lt; 0.01) and in a dose dependent manner, and the levels of TGF-beta1 and TNF were also increased but no statistical significance.	Polysaccharides	154-168	interleukin 1 beta	Homo sapiens	71-79
16494031-4	2005	RESULT: Compared with the control group, the levels of EGF, TGF-alpha, IL-1beta, IL-6 and IL-8 were significantly increased by treatment with Aloe coarse polysaccharide (P &lt; 0.05, P &lt; 0.01) and in a dose dependent manner, and the levels of TGF-beta1 and TNF were also increased but no statistical significance.	Polysaccharides	154-168	interleukin 6	Homo sapiens	81-85
16494031-4	2005	RESULT: Compared with the control group, the levels of EGF, TGF-alpha, IL-1beta, IL-6 and IL-8 were significantly increased by treatment with Aloe coarse polysaccharide (P &lt; 0.05, P &lt; 0.01) and in a dose dependent manner, and the levels of TGF-beta1 and TNF were also increased but no statistical significance.	Polysaccharides	154-168	C-X-C motif chemokine ligand 8	Homo sapiens	90-94
16494031-4	2005	RESULT: Compared with the control group, the levels of EGF, TGF-alpha, IL-1beta, IL-6 and IL-8 were significantly increased by treatment with Aloe coarse polysaccharide (P &lt; 0.05, P &lt; 0.01) and in a dose dependent manner, and the levels of TGF-beta1 and TNF were also increased but no statistical significance.	Polysaccharides	154-168	transforming growth factor beta 1	Homo sapiens	246-255
16494031-4	2005	RESULT: Compared with the control group, the levels of EGF, TGF-alpha, IL-1beta, IL-6 and IL-8 were significantly increased by treatment with Aloe coarse polysaccharide (P &lt; 0.05, P &lt; 0.01) and in a dose dependent manner, and the levels of TGF-beta1 and TNF were also increased but no statistical significance.	Polysaccharides	154-168	tumor necrosis factor	Homo sapiens	260-263
16494031-5	2005	CONCLUSION: Aloe coarse polysaccharide may promote keratinocytes to secrete EGF, TGF-alpha, IL-1beta, IL-6 and IL-8.	Polysaccharides	24-38	transforming growth factor alpha	Homo sapiens	81-90
16494031-5	2005	CONCLUSION: Aloe coarse polysaccharide may promote keratinocytes to secrete EGF, TGF-alpha, IL-1beta, IL-6 and IL-8.	Polysaccharides	24-38	interleukin 1 beta	Homo sapiens	92-100
16494031-5	2005	CONCLUSION: Aloe coarse polysaccharide may promote keratinocytes to secrete EGF, TGF-alpha, IL-1beta, IL-6 and IL-8.	Polysaccharides	24-38	interleukin 6	Homo sapiens	102-106
16494031-5	2005	CONCLUSION: Aloe coarse polysaccharide may promote keratinocytes to secrete EGF, TGF-alpha, IL-1beta, IL-6 and IL-8.	Polysaccharides	24-38	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
16303560-3	2005	For instance, CO2 is known to induce production of polysaccharide capsule virulence determinants in pathogenic bacteria and fungi via unknown mechanisms .	Polysaccharides	51-65	complement C2	Homo sapiens	14-17
15886002-0	2005	Amperometric biosensor based on tyrosinase-conjugated polysaccharide hybrid film: selective determination of nanomolar neurotransmitters metabolite of 3,4-dihydroxyphenylacetic acid (DOPAC) in biological fluid.	Polysaccharides	54-68	tyrosinase	Homo sapiens	32-42
16025538-8	2005	This analysis of N-glycans revealed that hEPO was modified to include paucimannosidic glycans containing two or three mannose residues with or without core fucose.	Polysaccharides	19-26	erythropoietin	Homo sapiens	41-45
16311888-5	2005	In the "3rd trimester" the amniotic fluid glycoconjugates contained higher relative amounts of glycans terminated by alpha2-6-linked sialic acid (p &lt; 0.00002) and by alpha1-6 innermost fucose (p &lt; 0.000001) than those in the 2nd trimester.	Polysaccharides	95-102	immunoglobulin binding protein 1	Homo sapiens	117-125
16275921-3	2005	Here we show that these zwitterionic polysaccharides can prevent T helper 1-mediated fibrosis by signaling for the release of IL-10 from CD4(+) T cells in vivo.	Polysaccharides	37-52	interleukin 10	Homo sapiens	126-131
16275921-3	2005	Here we show that these zwitterionic polysaccharides can prevent T helper 1-mediated fibrosis by signaling for the release of IL-10 from CD4(+) T cells in vivo.	Polysaccharides	37-52	CD4 molecule	Homo sapiens	137-140
16225657-6	2005	Finally, TSP adhesion of both sickle RBCs and dehydrated normal RBCs was inhibited by the anionic polysaccharides, chondroitin sulphate A and high molecular weight dextran sulphate, but not by competitors of CD47-, band 3-, or RBC phosphatidylserine-mediated adhesion.	Polysaccharides	98-113	CTR9 homolog, Paf1/RNA polymerase II complex component	Mus musculus	9-12
16141207-0	2005	Identification and molecular cloning of a novel glycoside hydrolase family of core 1 type O-glycan-specific endo-alpha-N-acetylgalactosaminidase from Bifidobacterium longum.	Polysaccharides	92-98	alpha-N-acetylgalactosaminidase	Homo sapiens	113-144
15936070-1	2005	We report a new template-directed method for the fabrication of hydroxyapatite (HAp) sponges by using amino-acid-coated HAp nanoparticles dispersed within a viscous polysaccharide (dextran sulfate) matrix, and describe the use of these materials for the viability and proliferation of human bone marrow stromal cells.	Polysaccharides	165-179	reticulon 3	Homo sapiens	80-83
16307480-2	2005	We show that this polysaccharide scaffold is a common secondary component of prions found in hamster full-length PrP(Sc), prion rods and in mouse ScN2a prions from cell culture.	Polysaccharides	18-32	sodium channel, voltage-gated, type II, alpha	Mus musculus	146-151
15972893-0	2005	Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6"-sulfo-sialyl Lewis X as a preferred glycan ligand.	Polysaccharides	170-176	sialic acid binding Ig-like lectin F	Mus musculus	6-14
15972893-0	2005	Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6"-sulfo-sialyl Lewis X as a preferred glycan ligand.	Polysaccharides	170-176	sialic acid binding Ig like lectin 8	Homo sapiens	25-33
16249330-0	2005	The search for glycan function: fucosylation of the TGF-beta1 receptor is required for receptor activation.	Polysaccharides	15-21	transforming growth factor beta 1	Homo sapiens	52-61
16081596-0	2005	Blockade of CTLA-4 (CD152) enhances the murine antibody response to pneumococcal capsular polysaccharides.	Polysaccharides	90-105	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	12-18
16081596-0	2005	Blockade of CTLA-4 (CD152) enhances the murine antibody response to pneumococcal capsular polysaccharides.	Polysaccharides	90-105	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	20-25
16239528-0	2005	Role of complement receptor type 2 and endogenous complement in the humoral immune response to conjugates of complement C3d and pneumococcal serotype 14 capsular polysaccharide.	Polysaccharides	162-176	complement receptor 2	Mus musculus	8-34
16253890-0	2005	Targeting the glycans of gp120: a novel approach aimed at the Achilles heel of HIV.	Polysaccharides	14-21	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	25-30
16253890-4	2005	I present a hypothesis that development of resistance against drugs that target the glycans on gp120 would result in a marked enhancement of neutralisation of HIV by the immune system--ie, drugs directed against the carbohydrate component of gp120 will select for mutant virus strains that progressively gain deletions in the glycosylation sites of gp120.	Polysaccharides	84-91	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	95-100
16253890-4	2005	I present a hypothesis that development of resistance against drugs that target the glycans on gp120 would result in a marked enhancement of neutralisation of HIV by the immune system--ie, drugs directed against the carbohydrate component of gp120 will select for mutant virus strains that progressively gain deletions in the glycosylation sites of gp120.	Polysaccharides	84-91	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	242-247
16253890-4	2005	I present a hypothesis that development of resistance against drugs that target the glycans on gp120 would result in a marked enhancement of neutralisation of HIV by the immune system--ie, drugs directed against the carbohydrate component of gp120 will select for mutant virus strains that progressively gain deletions in the glycosylation sites of gp120.	Polysaccharides	84-91	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	242-247
16187391-0	2005	1,5-Lactamized sialyl acceptors for various disialoside syntheses: novel method for the synthesis of glycan portions of Hp-s6 and HLG-2 gangliosides.	Polysaccharides	101-107	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3	Homo sapiens	120-125
16402554-0	2005	Stimulation of TNF-alpha release by fungal cell wall polysaccharides.	Polysaccharides	53-68	tumor necrosis factor	Mus musculus	15-24
16402554-2	2005	The polysaccharides were applied to peritoneal mouse macrophages and after a 2-h incubation the release of TNF-alpha by the stimulated macrophages was measured using an enzyme-linked immunosorbent assay.	Polysaccharides	4-19	tumor necrosis factor	Mus musculus	107-116
16402554-4	2005	In three concentrations of the polysaccharides applied, carboxymethyl glucan revealed a dramatic increase in the TNF-alpha release, while addition of carboxymethyl chitin-glucan resulted only in a moderate enhancement, and carboxymethyl chitin was inactive.	Polysaccharides	31-46	tumor necrosis factor	Mus musculus	113-122
16402554-5	2005	The results indicate that fungal polysaccharides, especially (1--&gt;3)-beta-D-glucan, are potent macrophage stimulators and activators of TNF-alpha release, which implies their potential application in antitumor therapy.	Polysaccharides	33-48	tumor necrosis factor	Mus musculus	139-148
16273902-0	2005	Serum creatine kinase response to exercise during dexamethasone-induced insulin resistance in Quarter Horses with polysaccharide storage myopathy.	Polysaccharides	114-128	INS	Equus caballus	72-79
16210648-0	2005	Carboxylated glycans mediate colitis through activation of NF-kappa B.	Polysaccharides	13-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	59-69
16210648-4	2005	We assessed the contribution of these glycans to the development of colitis induced by CD4(+)CD45RB(high) T cell transfer to Rag1(-/-) mice.	Polysaccharides	38-45	CD4 antigen	Mus musculus	87-90
16095580-6	2005	We predicted the substructure alpha-D-Neup5Ac-(2--&gt;3)-beta-D-Galp-(1--&gt;4)-D-GlcpNAc as a leukemia specific glycan motif.	Polysaccharides	113-119	galanin like peptide	Homo sapiens	64-68
15917430-6	2005	Molecular structure comparison for Man9GlcNAc2 recognition by ConA and 2G12 indicates that 2G12 has a more restricted specificity to high mannose glycans of gp120 which correlates with kinetic analysis assessed by surface plasmon resonance (SPR) and ConA inhibits 2G12 binding to gp120 but 2G12 does not inhibit ConA binding to gp120.	Polysaccharides	146-153	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	157-162
16194087-3	2005	A bottom-up approach to achieve full oligosaccharide and glycan characterization has been described that is based on an MSn fragment spectral library and associated tools.	Polysaccharides	57-63	moesin	Homo sapiens	120-123
15926885-11	2005	Mouse Gal3ST-2 preferred core 1 and type 2 glycans to type 1, and the K(m) values were much higher than those of human Gal3ST-2.	Polysaccharides	43-50	galactose-3-O-sulfotransferase 2	Mus musculus	6-14
16129482-5	2005	The neutral polysaccharide (ASP1) was rich in glucose, galactose, and arabinose suggesting a mixture of glucan and arabinogalactan.	Polysaccharides	12-26	audiogenic seizure prone 1	Mus musculus	28-32
16160185-7	2005	Our results suggest that elimination of glycan attachment sites 3 and 11 enhanced the exposure of contact residues for CD4.	Polysaccharides	40-46	CD4 molecule	Homo sapiens	119-122
16160185-8	2005	Thus, glycans at positions 3 and 11 of SIV239 gp120 may be particularly important for shielding the CD4-binding site from antibody recognition.	Polysaccharides	6-13	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	46-51
16160185-8	2005	Thus, glycans at positions 3 and 11 of SIV239 gp120 may be particularly important for shielding the CD4-binding site from antibody recognition.	Polysaccharides	6-13	CD4 molecule	Homo sapiens	100-103
16177349-6	2005	Furthermore, our data indicate that PorA-bound IgA1 is masked by the serogroup B polysaccharide capsule, rendering the IgA1 less accessible to degradation by secreted IgA1 protease present in the bacterial surroundings.	Polysaccharides	81-95	immunoglobulin heavy constant alpha 1	Homo sapiens	47-51
16177349-6	2005	Furthermore, our data indicate that PorA-bound IgA1 is masked by the serogroup B polysaccharide capsule, rendering the IgA1 less accessible to degradation by secreted IgA1 protease present in the bacterial surroundings.	Polysaccharides	81-95	immunoglobulin heavy constant alpha 1	Homo sapiens	119-123
16177349-6	2005	Furthermore, our data indicate that PorA-bound IgA1 is masked by the serogroup B polysaccharide capsule, rendering the IgA1 less accessible to degradation by secreted IgA1 protease present in the bacterial surroundings.	Polysaccharides	81-95	immunoglobulin heavy constant alpha 1	Homo sapiens	119-123
16179033-6	2005	Soluble antigens with altered glycans by treatment with sodium periodate significantly reduced the recruitment of F4/80(+)/Gr1(+)cells, concomitantly their suppressive activity was abrogated, indicating that glycans have a role in the early activation of these suppressor cells.	Polysaccharides	30-37	adhesion G protein-coupled receptor E1	Mus musculus	114-119
16179033-6	2005	Soluble antigens with altered glycans by treatment with sodium periodate significantly reduced the recruitment of F4/80(+)/Gr1(+)cells, concomitantly their suppressive activity was abrogated, indicating that glycans have a role in the early activation of these suppressor cells.	Polysaccharides	208-215	adhesion G protein-coupled receptor E1	Mus musculus	114-119
16145710-1	2005	The glycan structures of the major and more than ten minor populated isoforms of antithrombin (AT) were determined after separation of the isoforms by IEF using IPG strips.	Polysaccharides	4-10	serpin family C member 1	Homo sapiens	81-93
16129482-6	2005	The acidic polysaccharide (ASP2, ASP3) consisted mainly of galacturonic acid along with rhamnose, arabinose, and galactose indicating a pectic polysaccharide.	Polysaccharides	11-25	audiogenic seizure prone 2	Mus musculus	27-31
16129482-6	2005	The acidic polysaccharide (ASP2, ASP3) consisted mainly of galacturonic acid along with rhamnose, arabinose, and galactose indicating a pectic polysaccharide.	Polysaccharides	11-25	audiogenic seizure prone 3	Mus musculus	33-37
16129482-6	2005	The acidic polysaccharide (ASP2, ASP3) consisted mainly of galacturonic acid along with rhamnose, arabinose, and galactose indicating a pectic polysaccharide.	Polysaccharides	143-157	audiogenic seizure prone 2	Mus musculus	27-31
16129482-6	2005	The acidic polysaccharide (ASP2, ASP3) consisted mainly of galacturonic acid along with rhamnose, arabinose, and galactose indicating a pectic polysaccharide.	Polysaccharides	143-157	audiogenic seizure prone 3	Mus musculus	33-37
16159142-4	2005	This work also demonstrates that the MSn spectral library database, in particular, negative-ion MS2 spectral matching, can efficiently reduce the number of specific, sequential exoglycosidase digestions required and is useful for rapid structural analysis of unknown glycans not in the database.	Polysaccharides	267-274	moesin	Homo sapiens	37-40
16136229-2	2005	We recently revealed that the beta-1,3-glucans could interact with certain polynucleotides to form triple-stranded and helical macromolecular complexes consisting of two polysaccharide-strands and one polynucleotide-strand.	Polysaccharides	170-184	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	30-38
16136229-3	2005	This unique property of the beta-1,3-glucans has made it possible to utilize these polysaccharides as potential carriers for various functional polynucleotides.	Polysaccharides	83-98	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	28-36
16136229-9	2005	These unique properties of the beta-1,3-glucans undoubtedly originate from their inherent, very strong helix-forming character which has never been observed for other polysaccharides.	Polysaccharides	167-182	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	31-39
15983039-4	2005	MR transductants generated in glycosylation mutant cell lines lacked most mannose internalization activity, but could internalize sulfated glycans.	Polysaccharides	139-146	mannose receptor C-type 1	Homo sapiens	0-2
15983039-5	2005	Accordingly, purified MR bearing truncated Man5-GlcNAc2 glycans (Man5 -MR) or non-sialylated complex glycans (SA0-MR) did not bind mannosylated glycans, but could recognize SO4-3-Gal in vitro.	Polysaccharides	56-63	mannose receptor C-type 1	Homo sapiens	22-24
16118276-4	2005	This Vb beta-strand in B. cereus PI-PLC forms contacts with the glycan linker of GPI anchors, which presumably increases its activity on GPI-anchored proteins.	Polysaccharides	64-70	phospholipase C beta 1	Homo sapiens	33-39
16190894-2	2005	An interaction between apolipoprotein E (apoE) and glucosaminoglycans (GAG), polysaccharides linked to proteoglycans, has been proposed in this pathway.	Polysaccharides	77-92	apolipoprotein E	Homo sapiens	23-39
16127157-2	2005	The glycans that contribute to P- and E-selectin counterreceptor activity arise through glycosylation reactions in which the terminal steps are catalyzed by alpha(1,3) fucosyltransferases (FTs).	Polysaccharides	4-11	selectin, endothelial cell	Mus musculus	38-48
15853773-2	2005	GLCE (D-glucuronyl C5-epimerase), an enzyme responsible for the epimerization of D-glucuronic acid into L-iduronic acid of HS, endows the nascent polysaccharide chain with the ability to bind to growth factors and cytokines.	Polysaccharides	146-160	glucuronic acid epimerase	Homo sapiens	0-4
15853773-2	2005	GLCE (D-glucuronyl C5-epimerase), an enzyme responsible for the epimerization of D-glucuronic acid into L-iduronic acid of HS, endows the nascent polysaccharide chain with the ability to bind to growth factors and cytokines.	Polysaccharides	146-160	glucuronic acid epimerase	Homo sapiens	6-31
16190894-2	2005	An interaction between apolipoprotein E (apoE) and glucosaminoglycans (GAG), polysaccharides linked to proteoglycans, has been proposed in this pathway.	Polysaccharides	77-92	apolipoprotein E	Homo sapiens	41-45
15980069-3	2005	Here, we show that there are some fundamental differences between the ABC transporter-dependent pathway for O-PS biosynthesis and the capsular polysaccharide paradigm.	Polysaccharides	143-157	ABC transporter	Escherichia coli	70-85
16140770-6	2005	However, endoglycosidase H (endoH) digestion of the viral envelope (E) glycoprotein revealed that the acquisition of endoH-resistant glycans by E, but not endogenous major histocompatibility complex class I, was reduced in PP2-treated cells, demonstrating that E specifically does not traffic beyond the endoplasmic reticulum in the absence of SFK activity.	Polysaccharides	133-140	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	223-226
15982476-0	2005	Glycan moiety modifications of feline alpha1-acid glycoprotein in retrovirus (FIV, FeLV) affected cats.	Polysaccharides	0-6	alpha-1-acid glycoprotein	Felis catus	38-62
16081774-0	2005	A helminth glycan induces APC maturation via alternative NF-kappa B activation independent of I kappa B alpha degradation.	Polysaccharides	11-17	nuclear factor kappa B subunit 1	Homo sapiens	57-67
15982476-2	2005	In humans, AGP is a heavily glycosylated protein that undergoes several modifications of its glycan moiety during acute and chronic inflammatory pathologies.	Polysaccharides	93-99	alpha-1-acid glycoprotein	Felis catus	11-14
15953564-0	2005	A possible signal transduction pathway for cyclin D2 expression by a pectic polysaccharide from the roots of bupleurum falcatum L. in murine B cell.	Polysaccharides	76-90	cyclin D2	Mus musculus	43-52
15814589-2	2005	Sialyl Lewis x (sLe(x))-like glycans bind to E-selectin and are expressed at a relatively high level on circulating leukocytes.	Polysaccharides	29-36	selectin E	Homo sapiens	45-55
15958486-6	2005	As the nascent chains elongated and additional glycans were transferred, BiP binding rapidly decreased and the lectin-based chaperone system was recruited in its place.	Polysaccharides	47-54	heat shock protein family A (Hsp70) member 5	Homo sapiens	73-76
16010435-1	2005	Proteins and peptide bound polysaccharides (PSP) extracted from Basidiomycetous fungi are widely used in cancer immunotherapy and recently demonstrated to induce apoptosis in cancer cells in vitro.	Polysaccharides	27-42	microseminoprotein beta	Homo sapiens	44-47
15894585-0	2005	Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways.	Polysaccharides	0-14	mitogen-activated protein kinase 14	Homo sapiens	144-147
15894585-2	2005	The polysaccharide component with a branched (1--&gt;6)-beta-D-glucan moiety of G. lucidum (PS-G) has been reported to exert anti-tumor activity and activation of natural killer cells.	Polysaccharides	4-18	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	92-96
15958486-7	2005	The lectin chaperone calnexin bound to the nascent chain after the addition of two glycans, and calreticulin association followed upon the addition of a third.	Polysaccharides	83-90	calnexin	Homo sapiens	21-29
16051144-3	2005	Binding sites for the heavily sialylated receptor glycophorin A are proposed based on a complex of RII with a glycan that contains the essential components required for binding.	Polysaccharides	110-116	glycophorin A (MNS blood group)	Homo sapiens	50-63
16201406-5	2005	Even though rhLF contains oligomannose- and hybrid-type N-linked glycans next to complex-type glycans, which are the only glycans found on natural hLF, the structures are identical within the experimental error (r.m.s.	Polysaccharides	65-72	HLF transcription factor, PAR bZIP family member	Homo sapiens	13-16
15914327-1	2005	We show that APS, a polysaccharide isolated from the roots of Astragalus membranaceus, significantly induces nitric oxide (NO) production and inducible NO synthase (iNOS) transcription through the activation of nuclear factor-kappaB/Rel (NF-kappaB/Rel).	Polysaccharides	20-34	nitric oxide synthase 2, inducible	Mus musculus	165-169
15729692-1	2005	We previously found that an extracellular polysaccharide, AC-1, produced by Acetobacter polysaccharogenes composed of (1,4)-beta-D-glucan with branches of glucosyl residues showed a strong activity to induce production of interleukin (IL)-12 p40 and tumor necrosis factor-alpha by macrophage cell lines in vitro via Toll-like receptor-4 signaling.	Polysaccharides	42-56	adenylate cyclase 1	Mus musculus	58-62
15729692-1	2005	We previously found that an extracellular polysaccharide, AC-1, produced by Acetobacter polysaccharogenes composed of (1,4)-beta-D-glucan with branches of glucosyl residues showed a strong activity to induce production of interleukin (IL)-12 p40 and tumor necrosis factor-alpha by macrophage cell lines in vitro via Toll-like receptor-4 signaling.	Polysaccharides	42-56	toll-like receptor 4	Mus musculus	316-336
16039588-0	2005	More than one glycan is needed for ER glucosidase II to allow entry of glycoproteins into the calnexin/calreticulin cycle.	Polysaccharides	14-20	calnexin	Homo sapiens	94-102
16039588-0	2005	More than one glycan is needed for ER glucosidase II to allow entry of glycoproteins into the calnexin/calreticulin cycle.	Polysaccharides	14-20	calreticulin	Homo sapiens	103-115
16022893-1	2005	Regiospecific oxidation of the primary hydroxyl groups in lacquer polysaccharide (LPL, Mw 6.85 x 10(4)) and its NaIO4 oxidation derivatives (LPLde) to C-6 carboxy groups was achieved with NaOCl in the presence of Tempo and NaBr.	Polysaccharides	66-80	complement C6	Homo sapiens	151-154
15809287-6	2005	The polysaccharide elicits the release of IL-10 as well as the expression of IL-4 and TGF-beta in mucosa, and in spleen, the activation of CD3+ T cells occurs.	Polysaccharides	4-18	interleukin 10	Mus musculus	42-47
16013610-1	2005	The paper presents data on the primary structure of the glycan variants present in human antithrombin (AT) isoforms obtained from a plasma pool.	Polysaccharides	56-62	serpin family C member 1	Homo sapiens	89-101
16013610-1	2005	The paper presents data on the primary structure of the glycan variants present in human antithrombin (AT) isoforms obtained from a plasma pool.	Polysaccharides	56-62	serpin family C member 1	Homo sapiens	103-105
15809287-6	2005	The polysaccharide elicits the release of IL-10 as well as the expression of IL-4 and TGF-beta in mucosa, and in spleen, the activation of CD3+ T cells occurs.	Polysaccharides	4-18	interleukin 4	Mus musculus	77-81
15809287-6	2005	The polysaccharide elicits the release of IL-10 as well as the expression of IL-4 and TGF-beta in mucosa, and in spleen, the activation of CD3+ T cells occurs.	Polysaccharides	4-18	transforming growth factor, beta 1	Mus musculus	86-94
15845541-0	2005	Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands.	Polysaccharides	94-100	collectin subfamily member 12	Homo sapiens	25-57
15972675-5	2005	NiV infection of endothelial cells results in cell-cell fusion and syncytia formation triggered by the fusion (F) and attachment (G) envelope glycoproteins of NiV that bear glycan structures recognized by gal-1.	Polysaccharides	173-179	galectin 1	Homo sapiens	205-210
15896811-6	2005	These Stem Cell Factor (SCF) and Interleukin-3- (IL-3)-dependent PMC lines retain their capacity to growth after conventional freezing methods and exhibit most of the morphological and biochemical properties of normal, although immature, MCs, including metachromatic granules containing sulfated polysaccharides, the expression of c-kit and high-affinity IgE receptors (FcepsilonRI), and the ability to store histamine that is released upon cross-linking of FcepsilonRI.	Polysaccharides	296-311	KIT ligand	Sus scrofa	6-22
16408005-0	2005	Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking.	Polysaccharides	64-70	CD22 molecule	Homo sapiens	28-32
16408005-2	2005	As in other members of the sialic acid-binding immunoglobulin-like lectin, or siglec, family, the extracellular N-terminal immunoglobulin domain of CD22 binds to glycan ligands containing sialic acid, which are highly expressed on B-cell glycoproteins.	Polysaccharides	162-168	CD22 molecule	Homo sapiens	148-152
16408005-4	2005	To assess cell-surface cis ligand interactions, we developed a new method for in situ photoaffinity cross-linking of glycan ligands to CD22.	Polysaccharides	117-123	CD22 molecule	Homo sapiens	135-139
16408005-6	2005	Instead, CD22 seems to recognize glycans of neighboring CD22 molecules as cis ligands, forming homomultimeric complexes.	Polysaccharides	33-40	CD22 molecule	Homo sapiens	9-13
16408005-6	2005	Instead, CD22 seems to recognize glycans of neighboring CD22 molecules as cis ligands, forming homomultimeric complexes.	Polysaccharides	33-40	CD22 molecule	Homo sapiens	56-60
15954905-8	2005	Biotinylated lectins were used in enzyme-linked immunosorbent assay (ELISA) to examine different glycans on IgA1 molecules.	Polysaccharides	97-104	immunoglobulin heavy constant alpha 1	Homo sapiens	108-112
15944760-1	2005	Heparanase is endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix and basement membrane.	Polysaccharides	70-84	heparanase	Homo sapiens	0-10
15988320-3	2005	Human serum transferrin contains two biantennary glycans, each consisting of 0 to 4 molecules of sialic acid (SA); its SA content is heterogeneous with high concentration of tetrasialotransferrin (4SA) and low amounts of disialo-, trisialo-, penta-, and hexasialotransferrin.	Polysaccharides	49-56	transferrin	Homo sapiens	12-23
15845541-0	2005	Selective binding of the scavenger receptor C-type lectin to Lewisx trisaccharide and related glycan ligands.	Polysaccharides	94-100	fucosyltransferase 4	Homo sapiens	61-67
23674951-0	2005	The Effects of Rheum Tanguticum Polysaccharide on the Polarization of Th1 and Th2 Cells in TNBS-Induced Colitis in Murine.	Polysaccharides	32-46	negative elongation factor complex member C/D, Th1l	Mus musculus	70-73
15944324-4	2005	Treatment with mannose-BSA, a weak agonist of the MR containing a lower ratio of attached sugar compared with pure polysaccharides, before the addition of mannan inhibited COX-2 expression, whereas this was not observed when agonists other than mannan and zymosan were used.	Polysaccharides	115-130	prostaglandin-endoperoxide synthase 2	Homo sapiens	172-177
15797855-2	2005	HIV gp120 also binds to other cell surface components, including heparan sulfate (HS), a sulfated polysaccharide whose wide interactive properties are exploited by many pathogens for attachment and concentration at the cell surface.	Polysaccharides	98-112	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	4-9
16026261-0	2005	Glycans and glycan-binding proteins in brain: galectin-1-induced expression of neurotrophic factors in astrocytes.	Polysaccharides	0-7	galectin 1	Homo sapiens	46-56
23674951-0	2005	The Effects of Rheum Tanguticum Polysaccharide on the Polarization of Th1 and Th2 Cells in TNBS-Induced Colitis in Murine.	Polysaccharides	32-46	heart and neural crest derivatives expressed 2	Mus musculus	78-81
15896063-2	2005	The GPI anchors are covalently attached to the C-termini of proteins and consist of a glycan chain bonded to phosphatidylinositol with two acyl chains anchored into the membrane bilayer.	Polysaccharides	86-92	glucose-6-phosphate isomerase	Homo sapiens	4-7
15923638-6	2005	Together, our data support a novel model by which wt and F508del-CFTR undergo ERAD from two distinct checkpoints, the mutant being disposed of independently of N-glycosidic residues and calnexin, probably by the Hsc70/Hsp70 machinery, and wt CFTR undergoing glycan-mediated ERAD.	Polysaccharides	258-264	CF transmembrane conductance regulator	Homo sapiens	65-69
15784180-8	2005	Among polysaccharides and glycoconjugates, DTL-A binding to BSM was effectively inhibited by BSM, asialo-BSM, pronase-treated BSM and synthetic alpha-D-GalNAc-PAA.	Polysaccharides	6-21	denticleless E3 ubiquitin protein ligase homolog	Homo sapiens	43-46
15928868-2	2005	To obtain man-made ECM, the reconstitution of collagen could be conducted in the presence of negatively charged polysaccharide, such as alginate.	Polysaccharides	112-126	multimerin 1	Homo sapiens	19-22
15784621-4	2005	Data presented herein show that constitutive interaction of the pericellular polysaccharide, hyaluronan, with its receptor, CD44, regulates assembly and activation of an ErbB2-containing signaling complex, which in turn stimulates phosphoinositide 3-kinase activity in multidrug-resistant MCF-7/Adr human breast carcinoma cells.	Polysaccharides	77-91	CD44 molecule (Indian blood group)	Homo sapiens	124-128
15784621-4	2005	Data presented herein show that constitutive interaction of the pericellular polysaccharide, hyaluronan, with its receptor, CD44, regulates assembly and activation of an ErbB2-containing signaling complex, which in turn stimulates phosphoinositide 3-kinase activity in multidrug-resistant MCF-7/Adr human breast carcinoma cells.	Polysaccharides	77-91	erb-b2 receptor tyrosine kinase 2	Homo sapiens	170-175
15802303-4	2005	We have analyzed the carbohydrate specificity of the human C-type lectin macrophage galactose-type lectin (MGL) using glycan microarray profiling and identified an exclusive specificity for terminal alpha- and beta-linked GalNAc residues that naturally occur as parts of glycoproteins or glycosphingolipids.	Polysaccharides	118-124	C-type lectin domain containing 10A	Homo sapiens	107-110
15809094-2	2005	N-Acetylglucosaminyltransferase V (GnT-V) and its product, beta1-6-GlcNAc branching glycan, are known to correlate with tumor invasion and metastasis.	Polysaccharides	84-90	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	0-33
15809094-2	2005	N-Acetylglucosaminyltransferase V (GnT-V) and its product, beta1-6-GlcNAc branching glycan, are known to correlate with tumor invasion and metastasis.	Polysaccharides	84-90	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	35-40
15760905-0	2005	Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production.	Polysaccharides	66-72	CD48 molecule	Homo sapiens	76-80
15760905-0	2005	Functional role played by the glycosylphosphatidylinositol anchor glycan of CD48 in interleukin-18-induced interferon-gamma production.	Polysaccharides	66-72	interferon gamma	Homo sapiens	107-123
15604090-6	2005	On the other hand, these alpha1,6-fucosyltransferases could not act on N-glycopeptides already carrying core alpha1,3-fucose residues, whereas recombinant Drosophila and native Schistosoma core alpha1,3-fucosyltransferases were able to use core alpha1,6-fucosylated glycans as substrates.	Polysaccharides	266-273	nicotinic Acetylcholine Receptor alpha6	Drosophila melanogaster	25-33
15604092-2	2005	The glycan structures of the porcine ZP and the complete N-glycosylation pattern of the ZPB/ZPC oligomer has been recently described.	Polysaccharides	4-10	zona pellucida glycoprotein 4	Homo sapiens	88-91
15604092-2	2005	The glycan structures of the porcine ZP and the complete N-glycosylation pattern of the ZPB/ZPC oligomer has been recently described.	Polysaccharides	4-10	zona pellucida glycoprotein 3	Homo sapiens	92-95
15604092-4	2005	In-gel deglycosylation of the electrophoretically separated ZPA protein and comparison of the pattern obtained from the native, the desialylated and the endo-beta-galactosidase-treated glycoprotein allowed the assignment of the glycan structures by MALDI-TOF MS by considering the reported oligosaccharide structures.	Polysaccharides	228-234	zona pellucida glycoprotein 2	Homo sapiens	60-63
15604092-4	2005	In-gel deglycosylation of the electrophoretically separated ZPA protein and comparison of the pattern obtained from the native, the desialylated and the endo-beta-galactosidase-treated glycoprotein allowed the assignment of the glycan structures by MALDI-TOF MS by considering the reported oligosaccharide structures.	Polysaccharides	228-234	galactosidase beta 1	Homo sapiens	158-176
15855009-3	2005	We previously reported that a peptide (p458) from the sequence of the 60 kDa heat shock protein (HSP60) molecule in a conjugate vaccine can provide T cell help for the induction of protecting antibody against bacterial capsular polysaccharides.	Polysaccharides	228-243	heat shock protein family D (Hsp60) member 1	Homo sapiens	97-102
15837474-7	2005	Mica was used as a substrate to adsorb polysaccharide.	Polysaccharides	39-53	MHC class I polypeptide-related sequence A	Homo sapiens	0-4
15778117-7	2005	The concentration of TNF-alpha, IFN-gamma in serum increased significantly in the polysaccharide groups compared with the model control group, but IL-2 not.	Polysaccharides	82-96	tumor necrosis factor	Mus musculus	21-30
15778117-7	2005	The concentration of TNF-alpha, IFN-gamma in serum increased significantly in the polysaccharide groups compared with the model control group, but IL-2 not.	Polysaccharides	82-96	interferon gamma	Mus musculus	32-41
15802303-5	2005	Specific glycan structures containing terminal GalNAc moieties, expressed by the human helminth parasite Schistosoma mansoni as well as tumor antigens and a subset of gangliosides, were identified as ligands for MGL.	Polysaccharides	9-15	C-type lectin domain containing 10A	Homo sapiens	212-215
15904931-2	2005	Here, we describe the binding of beta2GPI to apoptotic cells using beta2GPI labelled with biotin-hydrazide (beta2GPI-bh) after oxidation of its glycan chains.	Polysaccharides	144-150	apolipoprotein H	Homo sapiens	33-41
15843550-6	2005	These data indicate that functional IGF-1R signaling is required for T cell-independent B cell responses in vivo, defining a novel regulatory mechanism for the immune response against bacterial polysaccharides.	Polysaccharides	194-209	insulin-like growth factor I receptor	Mus musculus	36-42
15860005-1	2005	A mutant called defective glycosylation1-1 (dgl1-1) was identified in Arabidopsis based on a growth defect of the dark-grown hypocotyl and an abnormal composition of the non-cellulosic cell wall polysaccharides.	Polysaccharides	195-210	dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit family protein	Arabidopsis thaliana	44-48
15904931-2	2005	Here, we describe the binding of beta2GPI to apoptotic cells using beta2GPI labelled with biotin-hydrazide (beta2GPI-bh) after oxidation of its glycan chains.	Polysaccharides	144-150	apolipoprotein H	Homo sapiens	67-75
15904931-2	2005	Here, we describe the binding of beta2GPI to apoptotic cells using beta2GPI labelled with biotin-hydrazide (beta2GPI-bh) after oxidation of its glycan chains.	Polysaccharides	144-150	apolipoprotein H	Homo sapiens	67-75
15904931-8	2005	It is not clear why the oxidation and biotinylation of glycan chains of beta2GPI increases its affinity for AnPL, but it seems that if such oxidative process occurs naturally, it could participate in enhancing antiphospholipid formation.	Polysaccharides	55-61	apolipoprotein H	Homo sapiens	72-80
15696547-6	2005	Since SLe(x) was reported to be a metastasis-associated glycan structure, the reduced expressions of SLe(x) and some enzymes related to its synthesis may be one of the mechanisms to explain the metastasis-suppressive effect of nm23-H1.	Polysaccharides	56-62	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	227-234
15701648-0	2005	Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro.	Polysaccharides	7-13	myelin-associated glycoprotein	Rattus norvegicus	28-58
15701648-10	2005	The ability to reverse MAG inhibition with monovalent glycosides encourages further exploration of glycans and glycan mimetics as blockers of MAG-mediated axon outgrowth inhibition.	Polysaccharides	99-106	myelin-associated glycoprotein	Rattus norvegicus	23-26
15701648-10	2005	The ability to reverse MAG inhibition with monovalent glycosides encourages further exploration of glycans and glycan mimetics as blockers of MAG-mediated axon outgrowth inhibition.	Polysaccharides	99-106	myelin-associated glycoprotein	Rattus norvegicus	142-145
16108375-1	2005	Klebsiella pneumoniae was cultured followed by the preparation and immunoactivity elucidating of its polysaccharide (CPS).	Polysaccharides	101-115	carbamoyl-phosphate synthetase 1	Mus musculus	117-120
15701648-10	2005	The ability to reverse MAG inhibition with monovalent glycosides encourages further exploration of glycans and glycan mimetics as blockers of MAG-mediated axon outgrowth inhibition.	Polysaccharides	99-105	myelin-associated glycoprotein	Rattus norvegicus	23-26
15701648-10	2005	The ability to reverse MAG inhibition with monovalent glycosides encourages further exploration of glycans and glycan mimetics as blockers of MAG-mediated axon outgrowth inhibition.	Polysaccharides	99-105	myelin-associated glycoprotein	Rattus norvegicus	142-145
15776384-4	2005	Results showed that subjects with cryptococcal polysaccharide in serum samples have significantly lower percentages of neutrophils, monocytes, and CD3+ T cells with L-selectin on their surfaces than do healthy subjects, regardless of HIV status.	Polysaccharides	47-61	selectin L	Homo sapiens	165-175
15776384-6	2005	Reduced L-selectin levels on leukocytes in subjects with circulating cryptococcal polysaccharide and increased serum levels of soluble L-selectin indicates that surface L-selectin shedding is a mechanism that likely explains reduced leukocyte extravasation into infected tissues of patients with disseminated cryptococcosis.	Polysaccharides	82-96	selectin L	Homo sapiens	8-18
15602655-0	2005	Identification of the protein components of protein-bound polysaccharide (PSK) that interact with NKL cells.	Polysaccharides	58-72	TAO kinase 2	Homo sapiens	74-77
15602655-1	2005	We identified the protein components of a protein-bound polysaccharide (PSK) that are responsible for the biological function of this immunomodulator in its interaction with NKL cells, an NK-derived cell line previously known to be activated by this extract, obtained from the basidiomycete Coriolus versiocolor.	Polysaccharides	56-70	TAO kinase 2	Homo sapiens	72-75
15791270-8	2005	We suggest a model whereby GNBP1 is involved in the hydrolysis of Gram-positive peptidoglycan producing new glycan reducing ends, which are subsequently detected by PGRP-SA.	Polysaccharides	87-93	Gram-negative bacteria binding protein 1	Drosophila melanogaster	27-32
15791270-8	2005	We suggest a model whereby GNBP1 is involved in the hydrolysis of Gram-positive peptidoglycan producing new glycan reducing ends, which are subsequently detected by PGRP-SA.	Polysaccharides	87-93	Peptidoglycan recognition protein SA	Drosophila melanogaster	165-172
15590773-7	2005	The low-molecular-weight derivatives obtained from the sulfated fucan were employed to determine the requirement for interaction of this polysaccharide with heparin cofactor II and to achieve complete thrombin inhibition.	Polysaccharides	137-151	coagulation factor II, thrombin	Homo sapiens	201-209
15756644-2	2005	We studied the induction and persistence of polysaccharide (PS)-specific memory in neonatal and infant mice primed with pneumococcal conjugate (Pnc1-TT) by assessing the response to native pneumococcal PS (PPS-1), the kinetics of the PPS-1-specific IgG response to a second Pnc1-TT dose and affinity maturation.	Polysaccharides	60-62	solute carrier family 25, member 33	Mus musculus	144-148
15819887-6	2005	We show that upon stimulation of HeLa cells by CXCL12, CXCR4 becomes tyrosine phosphorylated as expected, while syndecan-4 (but not syndecan-1, syndecan-2 or beta-glycan) also undergoes such tyrosine phosphorylation.	Polysaccharides	162-169	C-X-C motif chemokine ligand 12	Homo sapiens	47-53
15853914-1	2005	The immune response to polysaccharides is initiated when polysaccharides bind complement factor C3d, and these polysaccharide-C3d complexes subsequently localize on splenic marginal zone B cells strongly expressing CD21 (complement receptor 2).	Polysaccharides	23-38	endogenous retrovirus group K member 13	Homo sapiens	96-99
15769847-5	2005	We also analysed the involvement of the ER lectins Htm1p and Cne1p (yeast calnexin) in the glycan-based recognition process with respect to number and position of N-glycans.	Polysaccharides	91-97	alpha-1,2-mannosidase MNL1	Saccharomyces cerevisiae S288C	51-56
15769847-5	2005	We also analysed the involvement of the ER lectins Htm1p and Cne1p (yeast calnexin) in the glycan-based recognition process with respect to number and position of N-glycans.	Polysaccharides	91-97	calnexin	Saccharomyces cerevisiae S288C	61-66
15769847-6	2005	We observed that Htm1p function depends on the presence of N-glycans in general but that there is no positional preference for a particular glycan.	Polysaccharides	61-67	alpha-1,2-mannosidase MNL1	Saccharomyces cerevisiae S288C	17-22
15784561-0	2005	Effect of B7-2 and CD40 signals from activated antigen-presenting cells on the ability of zwitterionic polysaccharides to induce T-Cell stimulation.	Polysaccharides	103-118	CD86 molecule	Homo sapiens	10-14
15784561-0	2005	Effect of B7-2 and CD40 signals from activated antigen-presenting cells on the ability of zwitterionic polysaccharides to induce T-Cell stimulation.	Polysaccharides	103-118	CD40 molecule	Homo sapiens	19-23
15804606-0	2005	Alpha1-antitrypsin as model to assess glycan function in endoplasmic reticulum.	Polysaccharides	38-44	serpin family A member 1	Homo sapiens	0-18
15853914-1	2005	The immune response to polysaccharides is initiated when polysaccharides bind complement factor C3d, and these polysaccharide-C3d complexes subsequently localize on splenic marginal zone B cells strongly expressing CD21 (complement receptor 2).	Polysaccharides	23-38	endogenous retrovirus group K member 13	Homo sapiens	126-129
15853914-1	2005	The immune response to polysaccharides is initiated when polysaccharides bind complement factor C3d, and these polysaccharide-C3d complexes subsequently localize on splenic marginal zone B cells strongly expressing CD21 (complement receptor 2).	Polysaccharides	23-38	complement C3d receptor 2	Homo sapiens	215-219
15853914-1	2005	The immune response to polysaccharides is initiated when polysaccharides bind complement factor C3d, and these polysaccharide-C3d complexes subsequently localize on splenic marginal zone B cells strongly expressing CD21 (complement receptor 2).	Polysaccharides	57-72	endogenous retrovirus group K member 13	Homo sapiens	96-99
15853914-1	2005	The immune response to polysaccharides is initiated when polysaccharides bind complement factor C3d, and these polysaccharide-C3d complexes subsequently localize on splenic marginal zone B cells strongly expressing CD21 (complement receptor 2).	Polysaccharides	23-37	endogenous retrovirus group K member 13	Homo sapiens	96-99
15853914-1	2005	The immune response to polysaccharides is initiated when polysaccharides bind complement factor C3d, and these polysaccharide-C3d complexes subsequently localize on splenic marginal zone B cells strongly expressing CD21 (complement receptor 2).	Polysaccharides	23-37	endogenous retrovirus group K member 13	Homo sapiens	126-129
15853914-1	2005	The immune response to polysaccharides is initiated when polysaccharides bind complement factor C3d, and these polysaccharide-C3d complexes subsequently localize on splenic marginal zone B cells strongly expressing CD21 (complement receptor 2).	Polysaccharides	23-37	complement C3d receptor 2	Homo sapiens	215-219
15738292-9	2005	In order to identify IgA and IgG2 anti-polysaccharide nonresponders, all patients presenting with bronchiectasis of unknown aetiology should be immunised with a pneumococcal polysaccharide vaccine, and IgA and IgG2 isotype responses should be evaluated as well as the total antibody response.	Polysaccharides	174-188	CD79a molecule	Homo sapiens	202-205
15852231-6	2005	Trophoblast cells were incubated with GdA and various glycans of GdA.	Polysaccharides	54-61	progestagen associated endometrial protein	Homo sapiens	65-68
15852231-8	2005	The production of hCG, estrogen and progesterone was increased in GdA and glycan-treated cell cultures as compared to untreated trophoblast cell cultures.	Polysaccharides	74-80	hypertrichosis 2 (generalised, congenital)	Homo sapiens	18-21
15712371-8	2005	Furthermore, two kinds of glycans, with differing branch structures, could be distinguished by comparing the relative fragment ion abundances in the MS3 spectrum of [M+Na]+.	Polysaccharides	26-33	MS3	Homo sapiens	149-152
15715496-0	2005	Antithrombin activation by nonsulfated, non-polysaccharide organic polymer.	Polysaccharides	44-58	serpin family C member 1	Homo sapiens	0-12
15832687-1	2005	The effects of inorganic phosphate (Pi) status, light/dark and sucrose on expression of UDP-glucose pyrophosphorylase (UGPase) gene (Ugp), which is involved in sucrose/ polysaccharides metabolism, were investigated using Arabidopsis wild-type (wt) plants and mutants impaired in Pi and carbohydrate status.	Polysaccharides	169-184	UDP-GLUCOSE PYROPHOSPHORYLASE 1	Arabidopsis thaliana	88-117
15832687-1	2005	The effects of inorganic phosphate (Pi) status, light/dark and sucrose on expression of UDP-glucose pyrophosphorylase (UGPase) gene (Ugp), which is involved in sucrose/ polysaccharides metabolism, were investigated using Arabidopsis wild-type (wt) plants and mutants impaired in Pi and carbohydrate status.	Polysaccharides	169-184	UDP-GLUCOSE PYROPHOSPHORYLASE 1	Arabidopsis thaliana	119-125
15832687-1	2005	The effects of inorganic phosphate (Pi) status, light/dark and sucrose on expression of UDP-glucose pyrophosphorylase (UGPase) gene (Ugp), which is involved in sucrose/ polysaccharides metabolism, were investigated using Arabidopsis wild-type (wt) plants and mutants impaired in Pi and carbohydrate status.	Polysaccharides	169-184	UDP-GLUCOSE PYROPHOSPHORYLASE 1	Arabidopsis thaliana	133-136
15693064-4	2005	The results showed that glycans were not randomly distributed among the five potential glycosylation sites in kappa-casein.	Polysaccharides	24-31	casein kappa	Bos taurus	110-122
15715496-1	2005	Accelerated antithrombin inhibition of procoagulant enzymes has been exclusively achieved with polysulfated polysaccharides.	Polysaccharides	108-123	serpin family C member 1	Homo sapiens	12-24
15556936-0	2005	Dimeric galectin-1 binds with high affinity to alpha2,3-sialylated and non-sialylated terminal N-acetyllactosamine units on surface-bound extended glycans.	Polysaccharides	147-154	galectin 1	Homo sapiens	8-18
15709773-7	2005	Unlike DNA, fucoidan protected C1q from trypsin cleavage, indicating that this polysaccharide binds to the B moiety of the globular head.	Polysaccharides	79-93	complement C1q A chain	Homo sapiens	31-34
15556936-5	2005	Unexpectedly, dGal-1 bound free ligands in solution with relatively low affinity and displayed no preference for extended glycans, indicating that dGal-1 preferentially recognizes extended glycans only when they are surface-bound, such as found on cell surfaces.	Polysaccharides	189-196	Galactose-specific C-type lectin	Drosophila melanogaster	147-153
15545280-3	2005	The first N-linked glycan in ICAM-2 contacts an exposed tryptophan residue, defining a conserved glycan-W motif critical for the conformation of the integrin binding domain.	Polysaccharides	19-25	intercellular adhesion molecule 2	Homo sapiens	29-35
15545280-5	2005	Experiments with soluble molecules having the N-terminal two domains of human ICAMs identified glycans of the high mannose type N-linked to the second domain of the dendritic cell-specific ICAM-grabbing nonintegrin lectin-ligands ICAM-2 and ICAM-3.	Polysaccharides	95-102	intercellular adhesion molecule 2	Homo sapiens	230-236
15563466-0	2005	Glycan array screening reveals a candidate ligand for Siglec-8.	Polysaccharides	0-6	sialic acid binding Ig like lectin 8	Homo sapiens	54-62
15545280-5	2005	Experiments with soluble molecules having the N-terminal two domains of human ICAMs identified glycans of the high mannose type N-linked to the second domain of the dendritic cell-specific ICAM-grabbing nonintegrin lectin-ligands ICAM-2 and ICAM-3.	Polysaccharides	95-102	intercellular adhesion molecule 3	Homo sapiens	241-247
15545280-7	2005	High mannose glycans were absent in ICAM-1, which did not bind to the lectin, but they appeared in ICAM-1 mutants with additional N-linked glycosylation and lectin binding activity.	Polysaccharides	13-20	intercellular adhesion molecule 1	Homo sapiens	36-42
15545280-7	2005	High mannose glycans were absent in ICAM-1, which did not bind to the lectin, but they appeared in ICAM-1 mutants with additional N-linked glycosylation and lectin binding activity.	Polysaccharides	13-20	intercellular adhesion molecule 1	Homo sapiens	99-105
15699104-5	2005	Our findings set forth a new paradigm for humoral responses in which CD1 expression as well as a subset of CD8+ cells are required to provide helper function for Ab production against thymus-independent type 2 polysaccharides, similar to MHC class II-restricted CD4+ cells for protein Ags.	Polysaccharides	210-225	CD1 antigen complex	Mus musculus	69-72
15647349-4	2005	Cellulose synthase-like (Csl) genes are hypothesized to encode Golgi-localized beta-glycan synthases that polymerize the backbones of noncellulosic polysaccharides.	Polysaccharides	148-163	Suppressor of Hairless	Drosophila melanogaster	25-28
15760705-8	2005	We concluded that beta1-6 branched tri- and tetraantennary complex-type glycans have an important function in adhesion and migration in the studied cell lines.	Polysaccharides	72-79	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	18-25
15864432-6	2005	Double-staining analyses showed that lymphocytes expressing high levels of PNA-binding glycans (PNA(high) lymphocytes) were made up of the great majority of CD5(+), CD4(+) and CD8(+) cells, and of 30 and 50% of sIg-bearing lymphocytes in peripheral blood and in lymph nodes or spleen, respectively.	Polysaccharides	87-94	CD5 molecule	Equus caballus	157-160
15456735-8	2005	Coexpression of the human polypeptide-GalNAc-T4 transferase with MUC1(1.7TR)-IgG2a increased the glycan occupancy at Thr in PDTR, Ser in VTSA, and Ser in GSTA, supporting the function of GalNAc-T4 proposed from previous in vitro studies.	Polysaccharides	97-103	polypeptide N-acetylgalactosaminyltransferase 4	Homo sapiens	38-47
15456735-8	2005	Coexpression of the human polypeptide-GalNAc-T4 transferase with MUC1(1.7TR)-IgG2a increased the glycan occupancy at Thr in PDTR, Ser in VTSA, and Ser in GSTA, supporting the function of GalNAc-T4 proposed from previous in vitro studies.	Polysaccharides	97-103	mucin 1, cell surface associated	Homo sapiens	65-69
15456735-8	2005	Coexpression of the human polypeptide-GalNAc-T4 transferase with MUC1(1.7TR)-IgG2a increased the glycan occupancy at Thr in PDTR, Ser in VTSA, and Ser in GSTA, supporting the function of GalNAc-T4 proposed from previous in vitro studies.	Polysaccharides	97-103	polypeptide N-acetylgalactosaminyltransferase 4	Homo sapiens	187-196
15864432-6	2005	Double-staining analyses showed that lymphocytes expressing high levels of PNA-binding glycans (PNA(high) lymphocytes) were made up of the great majority of CD5(+), CD4(+) and CD8(+) cells, and of 30 and 50% of sIg-bearing lymphocytes in peripheral blood and in lymph nodes or spleen, respectively.	Polysaccharides	87-94	CD4 molecule	Equus caballus	165-168
15488604-4	2005	Binding of MBL to HIV is dependent on the high-mannose glycans on gp120 while host cell glycans incorporated into virions do not contribute substantially to this interaction.	Polysaccharides	55-62	mannose binding lectin 2	Homo sapiens	11-14
15488604-4	2005	Binding of MBL to HIV is dependent on the high-mannose glycans on gp120 while host cell glycans incorporated into virions do not contribute substantially to this interaction.	Polysaccharides	55-62	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	66-71
15488604-5	2005	It is notable that MBL, due to its specificity for the types of glycans that are abundant on gp120, has been shown to interact with all tested HIV strains.	Polysaccharides	64-71	mannose binding lectin 2	Homo sapiens	19-22
15488604-5	2005	It is notable that MBL, due to its specificity for the types of glycans that are abundant on gp120, has been shown to interact with all tested HIV strains.	Polysaccharides	64-71	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	93-98
15537650-0	2005	Glycan-independent role of calnexin in the intracellular retention of Charcot-Marie-tooth 1A Gas3/PMP22 mutants.	Polysaccharides	0-6	calnexin	Homo sapiens	27-35
15589322-1	2005	We determined the molecular sequence of monoclonal antibodies (mAbs) to serogroups B and C capsular polysaccharides (PS) of Neisseria meningitidis.	Polysaccharides	100-115	DEAD box helicase 41	Mus musculus	63-67
15641149-8	2005	CONCLUSION: Polysaccharides isolated from PG may inhibit BaP-induced forestomach carcinogenesis in mice bydown-regulating mutant p53 expression.	Polysaccharides	12-27	transformation related protein 53, pseudogene	Mus musculus	129-132
15537650-0	2005	Glycan-independent role of calnexin in the intracellular retention of Charcot-Marie-tooth 1A Gas3/PMP22 mutants.	Polysaccharides	0-6	peripheral myelin protein 22	Homo sapiens	93-97
15537650-0	2005	Glycan-independent role of calnexin in the intracellular retention of Charcot-Marie-tooth 1A Gas3/PMP22 mutants.	Polysaccharides	0-6	peripheral myelin protein 22	Homo sapiens	98-103
15537650-4	2005	Here, we show that calnexin interacts with the misfolded transmembrane domains of Gas3/PMP22, fused to green fluorescent protein, in a glycan-independent manner.	Polysaccharides	135-141	calnexin	Homo sapiens	19-27
15537650-4	2005	Here, we show that calnexin interacts with the misfolded transmembrane domains of Gas3/PMP22, fused to green fluorescent protein, in a glycan-independent manner.	Polysaccharides	135-141	peripheral myelin protein 22	Homo sapiens	82-86
15537650-4	2005	Here, we show that calnexin interacts with the misfolded transmembrane domains of Gas3/PMP22, fused to green fluorescent protein, in a glycan-independent manner.	Polysaccharides	135-141	peripheral myelin protein 22	Homo sapiens	87-92
15537650-6	2005	Our results support emerging models for a glycan-independent chaperone role for calnexin and for the mechanism of retention of misfolded membrane proteins in the endoplasmic reticulum.	Polysaccharides	42-48	calnexin	Homo sapiens	80-88
15596301-2	2005	The expression of core 2 beta1,6 N-acetylglucosaminyltransferase (C2GnT) by leukocytes allows for the biosynthesis of core 2 O-glycans that when terminated by sLeX can serve as high-affinity selectin glycan ligands.	Polysaccharides	127-133	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	18-64
15596301-2	2005	The expression of core 2 beta1,6 N-acetylglucosaminyltransferase (C2GnT) by leukocytes allows for the biosynthesis of core 2 O-glycans that when terminated by sLeX can serve as high-affinity selectin glycan ligands.	Polysaccharides	127-133	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	66-71
15635159-1	2005	Sodium spirulan (Na-SP) is a sulfated polysaccharide isolated from the blue-green alga Spirulina platensis.	Polysaccharides	38-52	nuclear autoantigenic sperm protein	Bos taurus	17-22
15317738-6	2005	Because such structures are known to be essential for different cell-cell recognition and adhesion processes, characterizing the CEACAM1 glycan structure is of pivotal importance in revealing the biological function of CEACAM1.	Polysaccharides	137-143	CEA cell adhesion molecule 1	Homo sapiens	129-136
15607641-0	2005	Protein-bound polysaccharide isolated from basidiomycetes inhibits endotoxin-induced activation by blocking lipopolysaccharide-binding protein and CD14 functions.	Polysaccharides	14-28	CD14 antigen	Mus musculus	147-151
15607641-1	2005	The protein-bound polysaccharide isolated from basidiomycetes (PSK) is a biological response modifier capable of exhibiting various biological activities, such as antitumor and antimicrobial effects.	Polysaccharides	18-32	TAO kinase 2	Mus musculus	63-66
15317738-6	2005	Because such structures are known to be essential for different cell-cell recognition and adhesion processes, characterizing the CEACAM1 glycan structure is of pivotal importance in revealing the biological function of CEACAM1.	Polysaccharides	137-143	CEA cell adhesion molecule 1	Homo sapiens	219-226
15317738-12	2005	The sequential digestions clearly identified several different Lewis x glycan epitopes, which may modulate the cell adhesive functions of CEACAM1.	Polysaccharides	71-77	CEA cell adhesion molecule 1	Homo sapiens	138-145
15618166-8	2005	Surprisingly, both MyD88(-/-) and TLR2(-/-) mice exhibit striking and equivalent defects in elicitation of type 1 IgG isotypes (IgG3, IgG2b, and IgG2a), but not the type 2 IgG isotype, IgG1, specific for several protein and polysaccharide antigens, in response to i.p.	Polysaccharides	224-238	myeloid differentiation primary response gene 88	Mus musculus	19-24
16424597-4	2005	Anti-capsular polysaccharide (PRP) of Hib specific IgM and IgG antibody concentrations were estimated using enzyme immunoassay.	Polysaccharides	14-28	prion protein	Homo sapiens	30-33
15618166-8	2005	Surprisingly, both MyD88(-/-) and TLR2(-/-) mice exhibit striking and equivalent defects in elicitation of type 1 IgG isotypes (IgG3, IgG2b, and IgG2a), but not the type 2 IgG isotype, IgG1, specific for several protein and polysaccharide antigens, in response to i.p.	Polysaccharides	224-238	toll-like receptor 2	Mus musculus	34-38
15448157-4	2004	However, it is conceivable that these glycans function as intermolecular binding sites during the de novo infection of cells on susceptible organisms and/or play a role for the interaction of both PrP isoforms.	Polysaccharides	38-45	prion protein	Mus musculus	197-200
15607116-3	2004	Analysis of C1 esterase inhibitor (C1INH) glycans from normal individuals and patients with hereditary deficiency of C1INH demonstrated identical O-glycan structures but the N-glycans of patients with a heterozygous genetic deficiency were small, highly charged and lacked sialidase releasable N-acetylneuraminic acid.	Polysaccharides	42-49	serpin family G member 1	Homo sapiens	12-33
15607116-3	2004	Analysis of C1 esterase inhibitor (C1INH) glycans from normal individuals and patients with hereditary deficiency of C1INH demonstrated identical O-glycan structures but the N-glycans of patients with a heterozygous genetic deficiency were small, highly charged and lacked sialidase releasable N-acetylneuraminic acid.	Polysaccharides	42-49	serpin family G member 1	Homo sapiens	35-40
15522220-2	2004	Inorganic pyrophosphatase (IPP) is an essential enzyme that plays a pivotal role in a broad spectrum of cellular biosynthetic reactions such as amino acid, nucleotide, polysaccharide, and fatty acid biosynthesis.	Polysaccharides	168-182	inorganic pyrophosphatase 1	Homo sapiens	0-25
15319280-6	2004	The increased sensitivity of B cells to glycan deficiencies was caused by lower expression levels of L-selectin; L-selectin(+/-) T cells expressing L-selectin levels equivalent to those of B cells exhibited intravascular behavior similar to that of B cells.	Polysaccharides	40-46	selectin, lymphocyte	Mus musculus	101-111
15319280-6	2004	The increased sensitivity of B cells to glycan deficiencies was caused by lower expression levels of L-selectin; L-selectin(+/-) T cells expressing L-selectin levels equivalent to those of B cells exhibited intravascular behavior similar to that of B cells.	Polysaccharides	40-46	selectin, lymphocyte	Mus musculus	113-123
15319280-6	2004	The increased sensitivity of B cells to glycan deficiencies was caused by lower expression levels of L-selectin; L-selectin(+/-) T cells expressing L-selectin levels equivalent to those of B cells exhibited intravascular behavior similar to that of B cells.	Polysaccharides	40-46	selectin, lymphocyte	Mus musculus	113-123
15541350-0	2004	Glycogen and related polysaccharides inhibit the laforin dual-specificity protein phosphatase.	Polysaccharides	21-36	EPM2A glucan phosphatase, laforin	Homo sapiens	49-56
15522220-2	2004	Inorganic pyrophosphatase (IPP) is an essential enzyme that plays a pivotal role in a broad spectrum of cellular biosynthetic reactions such as amino acid, nucleotide, polysaccharide, and fatty acid biosynthesis.	Polysaccharides	168-182	inorganic pyrophosphatase 1	Homo sapiens	27-30
15579440-7	2004	Treatment of rats with fucoidan, a sulfated polysaccharide which binds to stromal cell-derived factor-1 and blocks its biological effects, markedly decreased oval cell accumulation in five of the seven treated rats.	Polysaccharides	44-58	C-X-C motif chemokine ligand 12	Rattus norvegicus	74-103
15572450-4	2004	Although most interactions are with the peptide, the glycan moiety also seems to be essential for specific recognition by PGRPs.	Polysaccharides	53-59	peptidoglycan recognition protein 1	Homo sapiens	122-127
15583012-2	2004	Previous experiments have shown that antibody to specific intracellular adhesion molecule-grabbing nonintegrin (SIGN)-R1 inhibits uptake of capsular polysaccharide by marginal zone macrophages, suggesting a role for SIGN-R1 in this process.	Polysaccharides	149-163	CD209b antigen	Mus musculus	49-120
15583012-2	2004	Previous experiments have shown that antibody to specific intracellular adhesion molecule-grabbing nonintegrin (SIGN)-R1 inhibits uptake of capsular polysaccharide by marginal zone macrophages, suggesting a role for SIGN-R1 in this process.	Polysaccharides	149-163	CD209b antigen	Mus musculus	216-223
16114559-1	2004	OBJECTIVE: To determine the effects of polysaccharide nucleic acid fraction of bacillus calmette guerin (BCG-PSN) on serum levels of interleukin-4 (IL-4) and interleukin-12 (IL-12) in patients with condyloma acuminatum (CA) and to investigate the mechamism of immunoregulation of BCG-PSN on CA.	Polysaccharides	39-53	interleukin 4	Homo sapiens	148-152
15557623-1	2004	We previously found that AC-1, an extracellular polysaccharide, produced by Acetobacter xylinum and composed of (1,4)-beta-D-glucan with branches of glucosyl residues, showed a strong activity to induce production of interleukin-12 (IL-12) p40 and tumor necrosis factor alpha by macrophages in vitro via Toll-like receptor 4 (TLR-4) signaling.	Polysaccharides	48-62	adenylate cyclase 1	Mus musculus	25-29
15557623-1	2004	We previously found that AC-1, an extracellular polysaccharide, produced by Acetobacter xylinum and composed of (1,4)-beta-D-glucan with branches of glucosyl residues, showed a strong activity to induce production of interleukin-12 (IL-12) p40 and tumor necrosis factor alpha by macrophages in vitro via Toll-like receptor 4 (TLR-4) signaling.	Polysaccharides	48-62	toll-like receptor 4	Mus musculus	326-331
15610852-5	2004	Remarkably, proteasome-mediated turnover of class I MHC heavy chains proceeds even when PNGase is completely inhibited, suggesting that the function of PNGase may be to facilitate more efficient proteasomal proteolysis of N-linked glycoproteins through glycan removal.	Polysaccharides	253-259	N-glycanase 1	Homo sapiens	152-158
15253930-9	2004	Purified rNDST-1 requires Mn(2+) for its enzymatic activity, can utilize PAPS regenerated in vitro by the PAPS cycle (PAP plus para-nitrophenylsulfate in the presence of arylsulfotransferase IV), and with the addition of exogenous PAPS is capable of producing 60-65% N-sulfated heparosan from E. coli K5 polysaccharide or Pasteurella multocida polysaccharide.	Polysaccharides	304-318	N-deacetylase and N-sulfotransferase 1	Rattus norvegicus	9-16
15269183-7	2004	Taken together our results suggest that inflammation-induced transcriptional regulation exists for Golgi membrane transporters required for the synthesis of the inflammation-inducible ZIP code sulfo sLex glycans.	Polysaccharides	204-211	death associated protein kinase 3	Homo sapiens	184-187
15280192-4	2004	Selectin ligands must be alpha1-3 fucosylated to form glycan determinants such as sialyl Lewis x (sLe(x)).	Polysaccharides	54-60	adrenoceptor alpha 1D	Homo sapiens	25-33
15649864-0	2004	Histatin 5 inhibits apoptosis in human gingival fibroblasts induced by porphyromonas gingivalis cell-surface polysaccharide.	Polysaccharides	109-123	histatin 3	Homo sapiens	0-10
15649864-4	2004	P. gingivalis polysaccharide (PS) significantly inhibited HGF proliferation, but lipopolysaccharide and outer-membrane protein did not.	Polysaccharides	14-28	hepatocyte growth factor	Homo sapiens	58-61
15649864-4	2004	P. gingivalis polysaccharide (PS) significantly inhibited HGF proliferation, but lipopolysaccharide and outer-membrane protein did not.	Polysaccharides	30-32	hepatocyte growth factor	Homo sapiens	58-61
15649864-7	2004	Pretreatment of PS with histatin 5 restrained the inhibitory effect of PS on HGF proliferation.	Polysaccharides	16-18	histatin 3	Homo sapiens	24-34
15649864-7	2004	Pretreatment of PS with histatin 5 restrained the inhibitory effect of PS on HGF proliferation.	Polysaccharides	16-18	hepatocyte growth factor	Homo sapiens	77-80
15518824-5	2004	Thus, glycans present on gp120 may prevent the generation of antibodies that block the DC-SIGN-gp120 interactions.	Polysaccharides	6-13	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	25-30
15518824-5	2004	Thus, glycans present on gp120 may prevent the generation of antibodies that block the DC-SIGN-gp120 interactions.	Polysaccharides	6-13	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	95-100
15465338-0	2004	Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord blood.	Polysaccharides	0-15	neural cell adhesion molecule 1	Homo sapiens	88-92
15519703-0	2004	Functional differences in IgG anti-polysaccharide antibodies elicited by immunization of mice with C3d versus ovalbumin conjugates of pneumococcal serotype 14 capsular polysaccharide.	Polysaccharides	35-49	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	110-119
15519703-0	2004	Functional differences in IgG anti-polysaccharide antibodies elicited by immunization of mice with C3d versus ovalbumin conjugates of pneumococcal serotype 14 capsular polysaccharide.	Polysaccharides	168-182	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	110-119
15519703-1	2004	We previously have shown that conjugation of C3d to pneumococcal serotype type 14 capsular polysaccharide (PPS14) significantly enhances anti-PPS14 antibody production to a degree similar to that found when the T-dependent protein carrier ovalbumin (OVA) is coupled to PPS14.	Polysaccharides	91-105	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	239-248
15541293-5	2004	Both MAN I and MAN II exhibited essentially identical kinetic parameters for polysaccharides and a similar hydrolysis pattern of various oligomeric and polymeric substrates.	Polysaccharides	77-92	family with sequence similarity 168 member B	Homo sapiens	5-10
15541293-5	2004	Both MAN I and MAN II exhibited essentially identical kinetic parameters for polysaccharides and a similar hydrolysis pattern of various oligomeric and polymeric substrates.	Polysaccharides	77-92	mannosidase alpha class 2A member 1	Homo sapiens	15-21
15467190-0	2004	Immunogenic comparison of two coupling methods of marine polysaccharide to bovine serum albumin.	Polysaccharides	57-71	albumin	Mus musculus	82-95
15374609-8	2004	PL stimulated a dose-dependent increase in NO and TNF-alpha, but not in ROI production in PM.	Polysaccharides	0-2	tumor necrosis factor	Mus musculus	50-59
15374609-9	2004	We suggested that PL has cytotoxicity against Yac-1 cells through the up-regulation of NO and TNF-alpha production.	Polysaccharides	18-20	tumor necrosis factor	Mus musculus	94-103
15351317-0	2004	Activation of mitogen-activated protein kinases and AP-1 by polysaccharide isolated from the radix of Platycodon grandiflorum in RAW 264.7 cells.	Polysaccharides	60-74	jun proto-oncogene	Mus musculus	52-56
15507646-6	2004	Similar results were obtained with cells expressing only prM and E. Chimeric proteins containing the ectodomain of CD4 or CD8 fused to the transmembrane domains of prM or E were constructed, and their subcellular localization was studied by confocal immunofluorescence and by analyzing the maturation of their associated glycans.	Polysaccharides	321-328	CD4 molecule	Homo sapiens	115-118
15369698-1	2004	The polysaccharide fractions were isolated and purified from Phellodendron chinese SCHNEID, and antitumor activities were examined at dosages of 2, 5 and 10 mg/100 g. F-7 and F-8 showed the highest tumor inhibitory activities (inhibition ratio 96.4 and 98.2% in 2 mg/100 g), and in dose of 5 mg/100 g, the inhibitory ratios were 95.3 and 97.5%, respectively.	Polysaccharides	4-18	coagulation factor VII	Mus musculus	167-170
15369698-1	2004	The polysaccharide fractions were isolated and purified from Phellodendron chinese SCHNEID, and antitumor activities were examined at dosages of 2, 5 and 10 mg/100 g. F-7 and F-8 showed the highest tumor inhibitory activities (inhibition ratio 96.4 and 98.2% in 2 mg/100 g), and in dose of 5 mg/100 g, the inhibitory ratios were 95.3 and 97.5%, respectively.	Polysaccharides	4-18	coagulation factor VIII	Mus musculus	175-178
15351712-6	2004	In addition, GLPS significantly inhibited the binding of mouse peritoneal macrophages with polysaccharides from Astragalus membranaceus, which is known to bind directly with TLR4 on macrophage surface.	Polysaccharides	91-106	toll-like receptor 4	Mus musculus	174-178
15467190-1	2004	Two conjugates of marine polysaccharide (MPS) and bovine serum albumin (BSA) were prepared using two methods, periodate oxidation and reductive amination, with the intent of enhancing its immunogenicity.	Polysaccharides	25-39	paired box 5	Mus musculus	72-75
15375543-2	2004	MUC1 expressed by normal mammary epithelial cells, carries core 2 glycans but in breast carcinomas the simple core 1 based glycans are added.	Polysaccharides	66-73	mucin 1, transmembrane	Mus musculus	0-4
15504268-0	2004	Disease susceptibility to ST11 complex meningococci bearing serogroup C or W135 polysaccharide capsules, North America.	Polysaccharides	80-94	Pancreatic endocrine tumor suppressor	Homo sapiens	26-30
15504268-1	2004	Clusters of meningococcal disease caused by a hyperinvasive lineage of Neisseria meningitidis, the ST11 complex, bearing a serogroup C polysaccharide capsule, have been prominent in Europe and North America since the early 1990s.	Polysaccharides	135-149	Pancreatic endocrine tumor suppressor	Homo sapiens	99-103
15504268-3	2004	ST11 complex meningococci may also express serogroup W135 polysaccharide capsules.	Polysaccharides	58-72	Pancreatic endocrine tumor suppressor	Homo sapiens	0-4
15504268-5	2004	We found that most adults and almost all children were apparently susceptible to infection with ST11 complex meningococci bearing both C and W135 polysaccharide capsules, which suggests that a vaccine program directed against only serogroup C meningococci may be insufficient to prevent hyperinvasive ST11 disease.	Polysaccharides	146-160	Pancreatic endocrine tumor suppressor	Homo sapiens	96-100
15375543-2	2004	MUC1 expressed by normal mammary epithelial cells, carries core 2 glycans but in breast carcinomas the simple core 1 based glycans are added.	Polysaccharides	123-130	mucin 1, transmembrane	Mus musculus	0-4
15375543-3	2004	The binding of the monoclonal antibody SM3 to its peptide epitope in the tandem repeat of MUC1 is blocked by the branched core 2 glycans found on MUC1 expressed by normal cells.	Polysaccharides	129-136	mucin 1, transmembrane	Mus musculus	90-94
15375543-3	2004	The binding of the monoclonal antibody SM3 to its peptide epitope in the tandem repeat of MUC1 is blocked by the branched core 2 glycans found on MUC1 expressed by normal cells.	Polysaccharides	129-136	mucin 1, transmembrane	Mus musculus	146-150
15528850-15	2004	We concluded that the combination of polysaccharides and CMC had significant adhesion- and abscess-reducing effects compared with their single treatment and the effects may act by modifying the fibrinolytic capacity of uPA, uPAR and TNF-alpha produced from activated macrophages in a rat peritonitis model.	Polysaccharides	37-52	plasminogen activator, urokinase	Rattus norvegicus	219-222
15368267-5	2004	Hyaluronic acid (HA) is a highly elastic polysaccharide that is involved in natural valve morphogenesis and possesses binding interactions with FN.	Polysaccharides	41-55	fibronectin 1	Homo sapiens	144-146
15528850-15	2004	We concluded that the combination of polysaccharides and CMC had significant adhesion- and abscess-reducing effects compared with their single treatment and the effects may act by modifying the fibrinolytic capacity of uPA, uPAR and TNF-alpha produced from activated macrophages in a rat peritonitis model.	Polysaccharides	37-52	plasminogen activator, urokinase receptor	Rattus norvegicus	224-228
15528850-15	2004	We concluded that the combination of polysaccharides and CMC had significant adhesion- and abscess-reducing effects compared with their single treatment and the effects may act by modifying the fibrinolytic capacity of uPA, uPAR and TNF-alpha produced from activated macrophages in a rat peritonitis model.	Polysaccharides	37-52	tumor necrosis factor	Rattus norvegicus	233-242
15128590-0	2004	Lewis X-containing glycans are specific and potent competitive inhibitors of the binding of ZP3 to complementary sites on capacitated, acrosome-intact mouse sperm.	Polysaccharides	19-26	zona pellucida glycoprotein 3	Mus musculus	92-95
15470093-2	2004	Assembly of Saccharomyces cerevisiae GPIs includes the addition of a fourth, side-branching mannose (Man) to the third Man of the core GPI glycan by the Smp3 mannosyltransferase.	Polysaccharides	139-145	glucose-6-phosphate isomerase	Homo sapiens	37-40
15470093-2	2004	Assembly of Saccharomyces cerevisiae GPIs includes the addition of a fourth, side-branching mannose (Man) to the third Man of the core GPI glycan by the Smp3 mannosyltransferase.	Polysaccharides	139-145	phosphatidylinositol glycan anchor biosynthesis class Z	Homo sapiens	153-177
15470093-6	2004	Repression of CaSMP3 expression leads to accumulation of a GPI precursor glycolipid whose glycan headgroup contains three mannoses and bears a phosphodiester-linked substituent on its first Man.	Polysaccharides	90-96	glucose-6-phosphate isomerase	Homo sapiens	59-62
15351424-0	2004	Insulin sensitivity and skeletal muscle glucose transport in horses with equine polysaccharide storage myopathy.	Polysaccharides	80-94	INS	Equus caballus	0-7
15450746-5	2004	Secretory IgA glycans bind gut bacteria, and an unusual cluster of mannose residues on gp120, the surface coat protein of the HIV virus, is recognized by the novel "domain-swapped" IgG 2G12 serum antibody.	Polysaccharides	14-21	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	87-92
15128590-6	2004	The experiments described herein test the hypothesis that Le(x)-containing glycans are specific, competitive inhibitors of the binding of Alexa Fluor 568 fluorochrome (Alexa(568))-labeled ZP3 to sperm and, thus, bind the same sperm surface sites as ZP3.	Polysaccharides	75-82	zona pellucida glycoprotein 3	Mus musculus	188-191
15128590-6	2004	The experiments described herein test the hypothesis that Le(x)-containing glycans are specific, competitive inhibitors of the binding of Alexa Fluor 568 fluorochrome (Alexa(568))-labeled ZP3 to sperm and, thus, bind the same sperm surface sites as ZP3.	Polysaccharides	75-82	zona pellucida glycoprotein 3	Mus musculus	249-252
15128590-7	2004	Dose-response analyses demonstrated that these glycans are potent inhibitors (IC(50) approximately 180 nM), which at saturation, reduced Alexa(568)-ZP3 binding by approximately 70%.	Polysaccharides	47-54	zona pellucida glycoprotein 3	Mus musculus	148-151
15128590-8	2004	A Lewis A (Le(a))-capped glycan (Gal beta 3[Fuc alpha 4]GlcNAc) was also a potent inhibitor (IC(50) approximately 150-200 nM), but at saturation, it reduced Alexa(568)-ZP3 binding by only 30%.	Polysaccharides	25-31	zona pellucida glycoprotein 3	Mus musculus	168-171
15128591-5	2004	This glycan is recognized by approximately 70% of the ZP3 binding sites on capacitated, acrosome-intact mouse sperm, whereas Lewis A (Le(a); Gal beta 3[Fuc alpha 4]GlcNAc) is recognized by most of the remaining sites (Kerr et al.	Polysaccharides	5-11	zona pellucida glycoprotein 3	Mus musculus	54-57
15307199-2	2004	Capsular polysaccharides from serotypes 6B, 10A, 17F, 19A, 19F, and 20 contain a phosphodiester bond that connects the repeating units in these polysaccharides (also referred to as backbone phosphodiester bonds), and polysaccharides from serotypes 11A, 15B, 18C, and 23F contain a phosphodiester bond that links a side chain to their repeating units.	Polysaccharides	9-24	SLAM family member 7	Homo sapiens	54-57
15307199-2	2004	Capsular polysaccharides from serotypes 6B, 10A, 17F, 19A, 19F, and 20 contain a phosphodiester bond that connects the repeating units in these polysaccharides (also referred to as backbone phosphodiester bonds), and polysaccharides from serotypes 11A, 15B, 18C, and 23F contain a phosphodiester bond that links a side chain to their repeating units.	Polysaccharides	144-159	SLAM family member 7	Homo sapiens	54-57
15307199-2	2004	Capsular polysaccharides from serotypes 6B, 10A, 17F, 19A, 19F, and 20 contain a phosphodiester bond that connects the repeating units in these polysaccharides (also referred to as backbone phosphodiester bonds), and polysaccharides from serotypes 11A, 15B, 18C, and 23F contain a phosphodiester bond that links a side chain to their repeating units.	Polysaccharides	144-159	SLAM family member 7	Homo sapiens	54-57
15128591-7	2004	Herein, we test the hypothesis that Le(x)- and Le(a)-containing glycans, when clustered on a neoglycoprotein, bind ZP3 receptors on sperm and induce sperm to undergo the acrosome reaction via the same signaling pathways as ZP3.	Polysaccharides	64-71	zona pellucida glycoprotein 3	Mus musculus	115-118
15128591-7	2004	Herein, we test the hypothesis that Le(x)- and Le(a)-containing glycans, when clustered on a neoglycoprotein, bind ZP3 receptors on sperm and induce sperm to undergo the acrosome reaction via the same signaling pathways as ZP3.	Polysaccharides	64-71	zona pellucida glycoprotein 3	Mus musculus	223-226
15308721-7	2004	Altogether, our findings lead us to propose that each glycan chain controls the accessibility of PrP determinants located close upstream from their attachment site.	Polysaccharides	54-60	major prion protein	Ovis aries	97-100
15587083-4	2004	The examination of the cell wall ultrastructure of wood chips by transmission electron microscopy (TEM) after polysaccharide staining showed a characteristic fading of the staining of the S1/S2 and S2/S3 transition areas, supporting the idea that reactivity and organization of polysaccharides had changed after the oxalate treatments.	Polysaccharides	110-124	proteasome 26S subunit, non-ATPase 1	Homo sapiens	188-193
15356088-6	2004	However, in contrast to expectations, antigen-enriched IgG was skewed primarily toward IgG2 and IgG3, subclasses associated with polysaccharides and microorganisms, respectively.	Polysaccharides	129-144	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	96-100
15362105-4	2004	Various types of polymers, from neutral polyethylene glycols and polysaccharides (Ficolls, dextrans) to inert proteins, are shown to accelerate alpha-synuclein fibrillation.	Polysaccharides	65-80	synuclein alpha	Homo sapiens	144-159
15322035-1	2004	The major capsular polysaccharide of Cryptococcus neoformans, glucuronoxylomannan (GXM), is recognized by Toll-like receptor 2 (TLR2), TLR4, and CD14.	Polysaccharides	19-33	toll-like receptor 2	Mus musculus	128-132
15322035-1	2004	The major capsular polysaccharide of Cryptococcus neoformans, glucuronoxylomannan (GXM), is recognized by Toll-like receptor 2 (TLR2), TLR4, and CD14.	Polysaccharides	19-33	toll-like receptor 4	Mus musculus	135-139
15322035-1	2004	The major capsular polysaccharide of Cryptococcus neoformans, glucuronoxylomannan (GXM), is recognized by Toll-like receptor 2 (TLR2), TLR4, and CD14.	Polysaccharides	19-33	CD14 antigen	Mus musculus	145-149
15325432-1	2004	A sulphated polysaccharide (SP2) was isolated from the brown alga Sargassum patens.	Polysaccharides	12-26	Sp2 transcription factor	Homo sapiens	28-31
15325432-2	2004	SP2 inhibited the replication of herpes simplex virus type 2 (HSV-2) dose-dependently by 38.5-96.1% of the control level, after incubations with 0.78-12.5 microg/ml of the polysaccharide.	Polysaccharides	172-186	Sp2 transcription factor	Homo sapiens	0-3
15308721-8	2004	The monoglycoform-assigned and the allotype-restricted antibodies described here, the first to date, should provide further opportunities to investigate the involvement of each glycan chain in PrP conversion in relation to prion strain diversity and the basis of the resistance conferred by the Arg-171 amino acid.	Polysaccharides	177-183	major prion protein	Ovis aries	193-196
15316057-1	2004	BACKGROUND: Heparanase is an endoglycosidase that degrades heparan sulfate, the main polysaccharide constituent of the extracellular matrix and basement membrane.	Polysaccharides	85-99	heparanase	Mus musculus	12-22
15384486-8	2004	Furthermore, extraction of polysaccharides revealed that inactivation of ttsI abolishes the synthesis of the rhamnan component of the LPS.	Polysaccharides	27-42	response regulator	Sinorhizobium fredii NGR234	73-77
15201278-9	2004	sICAM-1 glycoforms carrying truncated glycans retained full ability to bind to LFA-1 on leukocytes.	Polysaccharides	38-45	integrin alpha L	Mus musculus	79-84
15070860-1	2004	Vesicular integral protein of 36 kDa (VIP36) is an intracellular lectin recognizing high-mannose type glycans and is highly expressed in salivary glands, especially the parotid gland, which secretes alpha-amylase in large quantities.	Polysaccharides	102-109	lectin, mannose-binding 2	Rattus norvegicus	0-36
15147241-3	2004	We now demonstrate that a specific sulphation pattern of the CS polysaccharide is required for the Th1-promoted activity, as other polysaccharides such as dextran and dextran sulphate do not significantly induce this activity.	Polysaccharides	131-146	negative elongation factor complex member C/D, Th1l	Mus musculus	99-102
15249203-1	2004	The immunopotentiating effect of the roots of Astragalus membranaceus, a medicinal herb, has been associated with its polysaccharide fractions (Astragalus polysaccharides, APS).	Polysaccharides	118-132	SH2B adaptor protein 2	Mus musculus	172-175
15070860-0	2004	The binding of VIP36 and alpha-amylase in the secretory vesicles via high-mannose type glycans.	Polysaccharides	87-94	lectin, mannose-binding 2	Rattus norvegicus	15-20
15070860-1	2004	Vesicular integral protein of 36 kDa (VIP36) is an intracellular lectin recognizing high-mannose type glycans and is highly expressed in salivary glands, especially the parotid gland, which secretes alpha-amylase in large quantities.	Polysaccharides	102-109	lectin, mannose-binding 2	Rattus norvegicus	38-43
15115750-8	2004	Based on these data a tumor-specific MUC1 epitope is defined comprising the ...PDTRP... sequence in a particular conformation essentially determined by O-glycosylation at its threonine with either GalNAcalpha1 or a related short glycan.	Polysaccharides	229-235	mucin 1, cell surface associated	Homo sapiens	37-41
15236479-3	2004	Positively charged polysaccharide, N,N-diethylaminoethyl dextran (DEAE-dextran) tended to form stable, uniform and smaller size particles carrying BMP.	Polysaccharides	19-33	bone morphogenetic protein 1	Homo sapiens	147-150
15222977-0	2004	Polysaccharide isolated from Poria cocos sclerotium induces NF-kappaB/Rel activation and iNOS expression through the activation of p38 kinase in murine macrophages.	Polysaccharides	0-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	60-69
15222977-0	2004	Polysaccharide isolated from Poria cocos sclerotium induces NF-kappaB/Rel activation and iNOS expression through the activation of p38 kinase in murine macrophages.	Polysaccharides	0-14	nitric oxide synthase 2, inducible	Mus musculus	89-93
15222977-0	2004	Polysaccharide isolated from Poria cocos sclerotium induces NF-kappaB/Rel activation and iNOS expression through the activation of p38 kinase in murine macrophages.	Polysaccharides	0-14	mitogen-activated protein kinase 14	Mus musculus	131-134
15222977-1	2004	In our previous studies, we showed that PCSC, a polysaccharide isolated from Poria cocos, activated macrophages to induce the translocation of NF-kappaB/Rel into nucleus and DNA binding to its cognate site in the promoter of iNOS gene [Int.	Polysaccharides	48-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-152
15222977-1	2004	In our previous studies, we showed that PCSC, a polysaccharide isolated from Poria cocos, activated macrophages to induce the translocation of NF-kappaB/Rel into nucleus and DNA binding to its cognate site in the promoter of iNOS gene [Int.	Polysaccharides	48-62	nitric oxide synthase 2, inducible	Mus musculus	225-229
15095092-5	2004	Some anionic polysaccharides at 0.04-0.2% w/v (e.g. gum arabic, pectin and hypochlorite-oxidised xyloglucan) promoted the XET activity of de-salted enzyme, especially if a sub-optimal concentration of NaCl was also present; others (e.g. homogalacturonan, 4- O-methyl-glucuronoxylan and alginate) were inhibitory.	Polysaccharides	13-28	xyloglucan:xyloglucosyl transferase 33	Arabidopsis thaliana	122-125
15381006-1	2004	The polysaccharide isolated from the gum exudate of palm Scheelea phalerata (SPN) was water-insoluble and composed of Fuc, Ara, Xyl, and uronic acid moieties in a 5:34:54:7 molar ratio: 12% of phenolics were also present.	Polysaccharides	4-18	DEAF1 transcription factor	Homo sapiens	77-80
15300205-2	2004	Complement receptor 3 (CR3; CD11b/CD18) contains 2 distinct binding sites, one that mediates adhesion and a lectin-like domain (LLD) that binds polysaccharides of microbial origin.	Polysaccharides	144-159	integrin subunit alpha M	Homo sapiens	28-33
15255868-6	2004	We showed that the PDI located in the vacuoles had high mannose glycans, but not complex glycans, which suggested that the ER resident was transported to the vacuoles independent of the medial/trans-Golgi complex.	Polysaccharides	64-71	probable protein disulfide-isomerase A6	Nicotiana tabacum	19-22
15300205-2	2004	Complement receptor 3 (CR3; CD11b/CD18) contains 2 distinct binding sites, one that mediates adhesion and a lectin-like domain (LLD) that binds polysaccharides of microbial origin.	Polysaccharides	144-159	integrin subunit beta 2	Homo sapiens	34-38
15296462-5	2004	A33 antigen naturally expressed in the SW1222 human colon cancer cell line (A33) also possessed a high abundance of high mannose glycans (72%).	Polysaccharides	129-136	glycoprotein A33	Homo sapiens	0-3
15228275-0	2004	Syntheses of 6-sulfo sialyl Lewis X glycans corresponding to the L-selectin ligand "sulfoadhesin".	Polysaccharides	36-43	selectin L	Homo sapiens	65-75
15296462-5	2004	A33 antigen naturally expressed in the SW1222 human colon cancer cell line (A33) also possessed a high abundance of high mannose glycans (72%).	Polysaccharides	129-136	glycoprotein A33	Homo sapiens	76-79
15261384-0	2004	Isolation and biological properties of polysaccharide CPS-1 from cultured Cordyceps militaris.	Polysaccharides	39-53	carbamoyl-phosphate synthetase 1	Mus musculus	54-59
15241555-5	2004	These findings indicate that the altered expression of GnT-V will change the glycan structure and function of EGFR, which may modify downstream signal transduction.	Polysaccharides	77-83	epidermal growth factor receptor	Homo sapiens	110-114
15261384-3	2004	The structure of polysaccharide CPS-1 was elucidated by sugar analysis, Smith degradation, IR and 13C-NMR spectroscopy.	Polysaccharides	17-31	carbamoyl-phosphate synthetase 1	Mus musculus	32-37
15213174-1	2004	Fut2-LacZ-null mice, which are a model of the human ABO and Lewis nonsecretor group, display increased susceptibility to experimental yeast vaginitis, indicating a role for alpha(1,2)fucosylated cervical glycans in mucosal defense.	Polysaccharides	204-211	fucosyltransferase 2	Mus musculus	0-4
15207617-5	2004	DC uptake of and signalling by VLP was inhibited by amiloride or cytochalasin D (CCD), but not by filipin treatment, and was blocked by several sulfated and non-sulfated polysaccharides and anti-CD16.	Polysaccharides	170-185	VHL like	Homo sapiens	31-34
17134389-9	2004	Furthermore, fusion of KDEL to the diabody derivative of PIPP, which contains an N-glycosylation site within the heavy chain variable domain, also resulted in a molecule lacking complex glycans.	Polysaccharides	186-193	inositol polyphosphate-5-phosphatase J	Homo sapiens	57-61
15213156-5	2004	This finding raises the possibility that the protection afforded by other bacterial Hsp60 proteins may be due to trace quantities of polysaccharide antigens carried by and acting in conjunction with the Hsps.	Polysaccharides	133-147	heat shock protein 1 (chaperonin)	Mus musculus	84-89
15219555-4	2004	In a prospective cohort and case-control studies from these regions, pneumococcal polysaccharide vaccine reduced pneumococcal disease in certain subgroups, particularly those with higher CD4+ T cells/microL.	Polysaccharides	82-96	CD4 molecule	Homo sapiens	187-190
15331092-4	2004	In order to determine the potential role(s) of the alpha4-fucosylation during vegetative development, transgenic tobacco plants overexpressing a human Lewis fucosyltransferase (hFUT3), which transfers a fucose residue in a alpha(1,4)-linkage on complex glycans, have been developed.	Polysaccharides	253-260	fucosyltransferase 3 (Lewis blood group)	Homo sapiens	177-182
15269982-8	2004	CONCLUSION: IFN-gamma is a cytokine with high binding affinity to heparin and carrageenans family but poor to CS-A and CS-C. ELISA is a simple, sensitive approach to detect the interaction of polysaccharides with cytokine in vitro.	Polysaccharides	192-207	interferon gamma	Homo sapiens	12-21
15503778-3	2004	RESULT: Phragmizes communis polysaccharide could obviously increase the activity of CAT, SOD, GSH-PX in blood, lower the levels of LPO in plasma and the thick liquid made of grinding the tissues of brain and liver, and markedly resist the atrophy of the thymus, spleen and brain tissues of aging mice.	Polysaccharides	28-42	lactoperoxidase	Mus musculus	131-134
15158676-1	2004	Analysis of glycans from erythrocyte membrane glycoproteins from beta1,4-galactosyltransferase-1 (beta4GalT-1)-deficient mice revealed moderately decreased galactosylation but comparable polylactosamine content compared to control beta4GalT-1(+/-) mice.	Polysaccharides	12-19	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	Mus musculus	65-96
15060079-5	2004	First, MBP stimulates MASP-2 autoactivation by increasing the rate of autocatalysis when MBP.MASP-2 complexes bind to a glycan-coated surface.	Polysaccharides	120-126	myelin basic protein	Homo sapiens	7-10
15060079-5	2004	First, MBP stimulates MASP-2 autoactivation by increasing the rate of autocatalysis when MBP.MASP-2 complexes bind to a glycan-coated surface.	Polysaccharides	120-126	MBL associated serine protease 2	Homo sapiens	22-28
15060079-5	2004	First, MBP stimulates MASP-2 autoactivation by increasing the rate of autocatalysis when MBP.MASP-2 complexes bind to a glycan-coated surface.	Polysaccharides	120-126	myelin basic protein	Homo sapiens	89-92
15060079-5	2004	First, MBP stimulates MASP-2 autoactivation by increasing the rate of autocatalysis when MBP.MASP-2 complexes bind to a glycan-coated surface.	Polysaccharides	120-126	MBL associated serine protease 2	Homo sapiens	93-99
15158676-1	2004	Analysis of glycans from erythrocyte membrane glycoproteins from beta1,4-galactosyltransferase-1 (beta4GalT-1)-deficient mice revealed moderately decreased galactosylation but comparable polylactosamine content compared to control beta4GalT-1(+/-) mice.	Polysaccharides	12-19	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	Mus musculus	98-109
15158680-0	2004	Recognition by TNF-alpha of the GPI-anchor glycan induces apoptosis of U937 cells.	Polysaccharides	43-49	tumor necrosis factor	Homo sapiens	15-24
15158680-2	2004	We found by using ELISA that TNF-alpha binds to the glycosylphosphatidylinositol (GPI) anchor glycans of carcinoembryonic antigen, human placental alkaline phosphatase (hAP), and Tamm-Horsfall glycoprotein.	Polysaccharides	94-101	tumor necrosis factor	Homo sapiens	29-38
15158680-2	2004	We found by using ELISA that TNF-alpha binds to the glycosylphosphatidylinositol (GPI) anchor glycans of carcinoembryonic antigen, human placental alkaline phosphatase (hAP), and Tamm-Horsfall glycoprotein.	Polysaccharides	94-101	retinoic acid receptor beta	Homo sapiens	169-172
15158680-5	2004	Thus, TNF-alpha binds to the GlcNAcbeta1--&gt;phosphate--&gt;6Man residue in GPI-anchor glycans.	Polysaccharides	88-95	tumor necrosis factor	Homo sapiens	6-15
15161239-2	2004	The glycosylation cystatin (glycocystatin) contained a polysaccharide chain that was composed of 50 DP of mannose residues.	Polysaccharides	55-69	cystatin C	Gallus gallus	18-26
15056662-6	2004	The monoglucosylated glycan proved to be both necessary and sufficient for in vitro binding of calreticulin to MHC class I molecules.	Polysaccharides	21-27	calreticulin	Homo sapiens	95-107
15136555-8	2004	The polysaccharide dextran, known from classical studies to elicit a T-independent response, and whose cellular uptake has been shown recently to be mediated by membrane-associated SIGN-R1, gave no binding signals with the soluble form of the protein.	Polysaccharides	4-18	CD209b antigen	Mus musculus	181-188
15217620-0	2004	Oligosaccharide and glycoprotein microarrays as tools in HIV glycobiology; glycan-dependent gp120/protein interactions.	Polysaccharides	75-81	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	92-97
15217620-2	2004	Here we employ carbohydrate and glycoprotein microarrays to analyze glycan-dependent gp120-protein interactions.	Polysaccharides	68-74	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	85-90
15241723-0	2004	Pregnancy-associated corticosteroid-binding globulin: high resolution separation of glycan isoforms.	Polysaccharides	84-90	serpin family A member 6	Homo sapiens	21-52
15285866-3	2004	It has recently been demonstrated that zwitterionic polysaccharides, in bacterial capsules, form complexes with CD4(+) T lymphocytes leading to abscess formation.	Polysaccharides	52-67	CD4 molecule	Homo sapiens	112-115
15163414-3	2004	Carbohydrates have been thought to stimulate immune responses independently of T cells; however, zwitterionic polysaccharides (ZPSs) from the capsules of some bacteria can activate CD4(+) T cells.	Polysaccharides	110-125	CD4 molecule	Homo sapiens	181-184
15112051-8	2004	Moreover, properly folded glycoproteins with mannose-trimmed glycans can be deglucosylated in the Golgi by endomannosidase, thereby releasing calreticulin and permitting formation of complex OS.	Polysaccharides	61-68	mannosidase endo-alpha	Homo sapiens	107-122
15293861-1	2004	The best-known example of terminal-glycan variation is the ABO histo-blood group polymorphism in humans.	Polysaccharides	35-41	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	59-62
14996843-0	2004	Antithrombin-mediated anticoagulant activity of sulfated polysaccharides: different mechanisms for heparin and sulfated galactans.	Polysaccharides	57-72	serpin family C member 1	Homo sapiens	0-12
14996843-15	2004	Our results demonstrate that the paradigm of heparin-antithrombin interaction cannot be extended to other sulfated polysaccharides.	Polysaccharides	115-130	serpin family C member 1	Homo sapiens	53-65
15121302-6	2004	This increase could be blocked in human DCs by addition of the polysaccharide mannan indicating that uptake might be mediated by the mannose receptor.	Polysaccharides	63-77	mannose receptor C-type 1	Homo sapiens	133-149
14592928-1	2004	Mucin glycans are the major determinant of mucin functions.	Polysaccharides	6-13	mucin 1, cell surface associated	Bos taurus	0-5
14592928-1	2004	Mucin glycans are the major determinant of mucin functions.	Polysaccharides	6-13	mucin 1, cell surface associated	Bos taurus	43-48
14592928-2	2004	Mucin glycan branch structures, which increase structural heterogeneity and thus functional potential, are extended from beta6 N-acetylglucosaminides formed by beta6 N-acetylglucosaminyltransferases (beta6GnT).	Polysaccharides	6-12	mucin 1, cell surface associated	Bos taurus	0-5
15112051-8	2004	Moreover, properly folded glycoproteins with mannose-trimmed glycans can be deglucosylated in the Golgi by endomannosidase, thereby releasing calreticulin and permitting formation of complex OS.	Polysaccharides	61-68	calreticulin	Homo sapiens	142-154
15054225-0	2004	Expression of UDP-glucose dehydrogenase reduces cell-wall polysaccharide concentration and increases xylose content in alfalfa stems.	Polysaccharides	58-72	UDP-glucose 6-dehydrogenase 1	Glycine max	14-39
15033937-6	2004	These results contrast the far simpler glycan profile found in Saccharomyces cerevisiae alg3-1 och1, indicating diverging Golgi processing in these two closely related yeasts.	Polysaccharides	39-45	ALG3 alpha-1,3- mannosyltransferase	Homo sapiens	88-92
15100290-5	2004	Also, when another carbohydrate was present in CDR1, CDR2, or CDR3 of the L chain, the V(H) CDR2 glycan remained high mannose.	Polysaccharides	97-103	cerebellar degeneration related protein 1	Homo sapiens	47-51
14749330-10	2004	The results show that the mucin polypeptide undergoes dimerization and then becomes substituted with GalNAc residues prior to glycan elaboration to produce a mature mucin dimer, which then undergoes multimerization.	Polysaccharides	126-132	LOC100508689	Homo sapiens	26-31
15118538-4	2004	Although TAFI activation can result from proteolysis by a number of proteases, the most likely physiologic activators are thrombin (in complex with the cofactor thrombomodulin) and plasmin (in complex with polysaccharide cofactors).	Polysaccharides	206-220	plasminogen	Homo sapiens	181-188
14991405-0	2004	l-Galactose replaces l-fucose in the pectic polysaccharide rhamnogalacturonan II synthesized by the l-fucose-deficient mur1 Arabidopsis mutant.	Polysaccharides	44-58	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	119-123
14991405-2	2004	We found that the mur1 mutation also affects the primary structure of the pectic polysaccharide rhamnogalacturonan II (RG-II).	Polysaccharides	81-95	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	18-22
15010302-3	2004	These include up to 12 glycan structures, made up of an unusual core type 2 sequence terminated with one, two, or three sialyl Lewis(x) sequences; this type of O-glycans could serve as E- and P-selectin ligands.	Polysaccharides	23-29	selectin P	Homo sapiens	192-202
15016849-4	2004	Importantly, our studies also indicate that glycans located within the immunologically silent face of gp120, specifically the C4 and V5 regions, also conferred on SF162 resistance to neutralization by anti-V3 loop, anti-CD4 binding site, and anti-gp41 MAbs but not by antibodies targeting the coreceptor binding site.	Polysaccharides	44-51	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	102-107
15102568-6	2004	However, the polysaccharide meningococcal vaccines (i.e., A and C; A, C and W-135; or A, C, Y and W-135) initially developed in the 1970s are generally poorly immunogenic in children or require repeated doses and do not produce long-lasting immunity.	Polysaccharides	13-27	teashirt zinc finger homeobox 1	Homo sapiens	64-81
15168893-1	2004	Clinical practice over the past decade has evolved to include new agents, LMWH and synthetic polysaccharides, that bind to and enhance the activity of antithrombin similar to UFH.	Polysaccharides	93-108	serpin family C member 1	Homo sapiens	151-163
14699098-3	2004	Calnexin has also been shown to bind polypeptides in vivo that do not possess a glycan of this form and to function in vitro as a molecular chaperone for nonglycosylated proteins.	Polysaccharides	80-86	calnexin	Homo sapiens	0-8
14998720-1	2004	Sodium spirulan (Na-SP) is a sulfated polysaccharide with M(r) approximately 220,000 isolated from the blue-green alga Spirulina platensis.	Polysaccharides	38-52	nuclear autoantigenic sperm protein	Bos taurus	17-22
14998720-7	2004	The present data suggest that Na-SP is a potent inhibitor of arterial smooth muscle cell proliferation, and the inhibitory effect requires a certain minimum sequence of polysaccharide structure whose molecular conformation is maintained by sodium ion bound to sulfate group.	Polysaccharides	169-183	nuclear autoantigenic sperm protein	Bos taurus	30-35
15073305-3	2004	The cluster encodes dTDP-L-rhamnose biosynthesis (rml operon), required for building up the polyrhamnan S-layer glycan, as well as for assembly and export of the elongated glycan chain, and its transfer to the S-layer protein.	Polysaccharides	112-118	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	20-24
15161006-5	2004	TGF-beta inhibited the IL-2-induced lymphocyte activation of proliferative responses, cytotoxic activities and CD25+ cell population, the inhibitions of which were abrogated with PS-K. PS-K also abrogated the TGF-beta-induced anchorage-independent growth of normal rat kidney cells.	Polysaccharides	179-182	transforming growth factor beta 1	Homo sapiens	0-8
15161006-5	2004	TGF-beta inhibited the IL-2-induced lymphocyte activation of proliferative responses, cytotoxic activities and CD25+ cell population, the inhibitions of which were abrogated with PS-K. PS-K also abrogated the TGF-beta-induced anchorage-independent growth of normal rat kidney cells.	Polysaccharides	179-182	interleukin 2	Homo sapiens	23-27
15161006-5	2004	TGF-beta inhibited the IL-2-induced lymphocyte activation of proliferative responses, cytotoxic activities and CD25+ cell population, the inhibitions of which were abrogated with PS-K. PS-K also abrogated the TGF-beta-induced anchorage-independent growth of normal rat kidney cells.	Polysaccharides	179-182	interleukin 2 receptor subunit alpha	Homo sapiens	111-115
15161006-5	2004	TGF-beta inhibited the IL-2-induced lymphocyte activation of proliferative responses, cytotoxic activities and CD25+ cell population, the inhibitions of which were abrogated with PS-K. PS-K also abrogated the TGF-beta-induced anchorage-independent growth of normal rat kidney cells.	Polysaccharides	179-182	transforming growth factor, beta 1	Rattus norvegicus	209-217
14627436-4	2004	A number of apolar and polar PIM intermediates were labelled when this system was continuously labelled or pulse-chase-labelled with GDP-[3H]Man, and the glycan head groups and the acylation states of these species were determined by chemical and enzymic treatments and octyl-Sepharose chromatography respectively.	Polysaccharides	154-160	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	29-32
15061696-0	2004	Effect of polysaccharides and human plasma lipoproteins on the secretion of cystatin C by peritoneal macrophages from normal and tumor bearing mice.	Polysaccharides	10-25	cystatin C	Homo sapiens	76-86
15061696-2	2004	Polysaccharides stimulated cystatin C secretion: lipopolysaccharide &lt; carboxymethylated beta-D-glucan &lt; sulfoethylated beta-D-glucan.	Polysaccharides	0-15	cystatin C	Mus musculus	27-37
15061696-4	2004	Peritoneal macrophages from mice with experimental HA-1 hepatoma compared to those from intact mice secreted more cystatin C with maximum polysaccharide-stimulated secretion after 30 min of incubation.	Polysaccharides	138-152	cystatin C	Mus musculus	114-124
14973085-1	2004	dTDP-rhamnose is an important precursor of cell wall polysaccharides and rhamnose-containing exopolysaccharides (EPS) in Lactococcus lactis.	Polysaccharides	53-68	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	0-4
14992794-3	2004	The present experiments were undertaken to explore if L-fucose and fucose-rich polysaccharides (FROP-s) could influence elastin biosynthesis.	Polysaccharides	79-94	elastin	Homo sapiens	120-127
15036459-9	2004	The data obtained demonstrate that the YMP may be used as sources of immunoactive polysaccharides.	Polysaccharides	82-97	epithelial membrane protein 3	Mus musculus	39-42
14576172-10	2004	Thus Gal-1 binds terminal beta4Gal residues, and its binding affinity is enhanced significantly by the presence of this determinant on long-chain PL or chimeric polysaccharides.	Polysaccharides	161-176	galectin 1	Homo sapiens	5-10
14767513-1	2004	To identify responders when protein-bound polysaccharide (PSK) is used in adjuvant immunochemotherapy after curative resection of colorectal cancers, we examined the host and tumor factors that affect the prognosis incorporating the age factor.	Polysaccharides	42-56	TAO kinase 2	Homo sapiens	58-61
14576172-0	2004	Human galectin-1 recognition of poly-N-acetyllactosamine and chimeric polysaccharides.	Polysaccharides	70-85	galectin 1	Homo sapiens	6-16
14576173-11	2004	Endocervical expression of Fut2 in estrus and pregnancy may modify cervical mucus barrier properties from microbial infection analogous to the potential role of mucosal glycans in humans.	Polysaccharides	169-176	fucosyltransferase 2	Homo sapiens	27-31
14576172-6	2004	Gal-1 bound to immobilized Galbeta4GlcNAcbeta3Galbeta4Glc-BSA with an apparent K(d) of approximately 23 micro M but bound better to BSA conjugates with long PL and chimeric polysaccharide sequences (K(d)"s ranging from 11.9 +/- 2.9 microM to 20.9 +/- 5.1 micro M).	Polysaccharides	173-187	galectin 1	Homo sapiens	0-5
14730971-1	2004	The N-terminal region residues, Lys11, Arg13, and Arg24, of the plasma coagulation inhibitor, antithrombin, have been implicated in binding of the anticoagulant polysaccharide, heparin, from the identification of natural mutants with impaired heparin binding or by the X-ray structure of a complex of the inhibitor with a high-affinity heparin pentasaccharide.	Polysaccharides	161-175	serpin family C member 1	Homo sapiens	94-106
14728722-3	2004	In addition to its intracellular location XDH/XOD is also associated to the polysaccharide chains of proteoglycans on the external endothelial cell membrane.	Polysaccharides	76-90	xanthine dehydrogenase	Rattus norvegicus	42-45
14733546-1	2004	Chemical syntheses are reported for prostate specific antigen (PSA) N-linked glycopeptide fragments consisting of an uneicosapeptide (residues 27-47 of PSA) with di-, tri-, and tetrabranched N-acetyllactosamine-type glycans.	Polysaccharides	216-223	kallikrein related peptidase 3	Homo sapiens	36-61
14733546-1	2004	Chemical syntheses are reported for prostate specific antigen (PSA) N-linked glycopeptide fragments consisting of an uneicosapeptide (residues 27-47 of PSA) with di-, tri-, and tetrabranched N-acetyllactosamine-type glycans.	Polysaccharides	216-223	kallikrein related peptidase 3	Homo sapiens	63-66
15132871-6	2004	RESULTS: Chemical test showed that the nature of substance AP3 was polysaccharide.	Polysaccharides	67-81	adaptor-related protein complex 3, beta 1 subunit	Mus musculus	59-62
14698884-2	2004	Sialoadhesin (siglec-1) is expressed at much higher levels in inflammatory macrophages and specifically binds to alpha-2,3-sialylated N-acetyl lactosamine residues of glycan chains.	Polysaccharides	167-173	sialic acid binding Ig like lectin 1	Homo sapiens	0-12
14698884-2	2004	Sialoadhesin (siglec-1) is expressed at much higher levels in inflammatory macrophages and specifically binds to alpha-2,3-sialylated N-acetyl lactosamine residues of glycan chains.	Polysaccharides	167-173	sialic acid binding Ig like lectin 1	Homo sapiens	14-22
12947004-6	2004	Treatment of RBCs with the anionic polysaccharide dextran sulfate inhibited mutant RBC adhesion to TSP (P &lt;.001).	Polysaccharides	35-49	thrombospondin 1	Homo sapiens	99-102
14728722-5	2004	Taking into account the ability of alpha-amylase to hydrolyze the internal alpha-1,4 linkages of polysaccharides, we wanted to elucidate the involvement of alpha-amylase in XDH/XOD mobilization from the gastrointestinal endothelial cell surface and the relevance of the ascitic fluid (AF) as the source of alpha-amylase in experimental acute pancreatitis.	Polysaccharides	97-112	xanthine dehydrogenase	Rattus norvegicus	173-176
14705935-3	2004	To provide further insight into these lectin-glycan interactions, we are investigating the interaction of CRT with various sugars.	Polysaccharides	45-51	calreticulin	Homo sapiens	106-109
14705935-5	2004	Here, we have systematically mutated the residues implicated by the model in the interaction of CRT to its sugar substrates and categorized the role played by each of the subsites of calreticulin toward the glycan binding.	Polysaccharides	207-213	calreticulin	Homo sapiens	183-195
14705935-8	2004	The mutation of residues from the primary binding site of CRT, i.e., those interacting with glucose, appears to be far less tolerated as compared to mutations in residues that interact with the mannose residues of the glycan.	Polysaccharides	218-224	calreticulin	Homo sapiens	58-61
14706853-0	2004	beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans.	Polysaccharides	99-106	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	Homo sapiens	0-41
14694198-0	2004	The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen.	Polysaccharides	58-72	CD209b antigen	Mus musculus	18-25
14694198-3	2004	To assess the role of the capsular polysaccharide of S. pneumoniae (CPS) in the interaction of SIGN-R1 with pneumococci, we first studied binding and uptake of serotype 14 CPS in transfected cells.	Polysaccharides	35-49	CD209b antigen	Mus musculus	95-102
14706853-0	2004	beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans.	Polysaccharides	99-106	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	Homo sapiens	43-53
14706853-2	2004	Here we show that beta3Gn-T7 efficiently acts on keratan sulfate-related glycans including Galbeta1--&gt;4(SO(3)(-)--&gt;6)GlcNAcbeta1--&gt;3Galbeta1--&gt;4(SO(3)(-)--&gt;6)GlcNAc (L2L2), while lacto-N-tetraose and lacto-N-neo-tetraose were poor substrates.	Polysaccharides	73-80	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7	Homo sapiens	18-28
15467395-4	2004	We have found that IL-2 recognizes a high-mannose type glycan on the alpha subunit of the IL-2 receptor as well as a peptide portion of this subunit.	Polysaccharides	55-61	interleukin 2	Homo sapiens	19-23
15000485-0	2004	Inhibition of cytochrome P450 isozymes and ornithine decarboxylase activities by polysaccharides from soybeans fermented with Phellinus igniarius or Agrocybe cylindracea.	Polysaccharides	81-96	ornithine decarboxylase	Glycine max	43-66
15000485-2	2004	The polysaccharides (5, 10 and 25 microg ml(-1)) also suppressed 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity.	Polysaccharides	4-19	ornithine decarboxylase	Glycine max	110-133
15000485-3	2004	The most potent inhibitors of cytochrome P450 isozymes and ornithine decarboxylase activities were the polysaccharides from soybeans fermented with Agrocybe cylindracea.	Polysaccharides	103-118	ornithine decarboxylase	Glycine max	59-82
14686925-2	2004	Computational analysis of glycan conformation with prolonged simulation periods in vacuo and in a solvent box revealed two main effects: backfolding of the alpha1-6 arm and stacking of the bisecting GlcNAc and the neighboring Man/GlcNAc residues of both antennae.	Polysaccharides	26-32	adrenoceptor alpha 1D	Homo sapiens	156-164
15316277-6	2004	The S-layer glycosylation (slg) gene clusters of four of the 11 known S-layer glycan structures from members of the Bacillaceae have now been studied.	Polysaccharides	78-84	sialic acid binding Ig like lectin 12	Homo sapiens	4-25
15316277-6	2004	The S-layer glycosylation (slg) gene clusters of four of the 11 known S-layer glycan structures from members of the Bacillaceae have now been studied.	Polysaccharides	78-84	sialic acid binding Ig like lectin 12	Homo sapiens	27-30
15316281-9	2004	N-cadherin from WM35 (primary tumor site) possessed high-mannose and biantennary complex type glycans with alpha2-6 linked sialic acid.	Polysaccharides	94-101	cadherin 2	Homo sapiens	0-10
15467395-4	2004	We have found that IL-2 recognizes a high-mannose type glycan on the alpha subunit of the IL-2 receptor as well as a peptide portion of this subunit.	Polysaccharides	55-61	interleukin 2	Homo sapiens	90-94
15316281-10	2004	N-cadherin from WM239, WM9, and A375 cell lines possessed mostly tri- or tetra-antennary complex type glycans.	Polysaccharides	102-109	cadherin 2	Homo sapiens	0-10
15467395-6	2004	We have also shown that TNF-alpha recognizes the second mannose 6-phosphate diester of the glycan portion of glycosylphosphatidylinositol (GPI)-anchored glycoproteins.	Polysaccharides	91-97	tumor necrosis factor	Homo sapiens	24-33
15486458-0	2004	Synthesis of fluorine substituted oligosaccharide analogues of monoglucosylated glycan chain, a proposed ligand of lectin-chaperone calreticulin and calnexin.	Polysaccharides	80-86	calreticulin	Homo sapiens	132-144
15486458-0	2004	Synthesis of fluorine substituted oligosaccharide analogues of monoglucosylated glycan chain, a proposed ligand of lectin-chaperone calreticulin and calnexin.	Polysaccharides	80-86	calnexin	Homo sapiens	149-157
14975365-0	2004	Promotion of Sophora subprosrate polysaccharide on nitric oxide and interleukin-2 production in murine T lymphocytes: implicated Ca2+ and protein kinase C. SSP1, a polysaccharide isolated from Sophora subprosrate, increased the productions of nitric oxide (NO) and interleukin-2 (IL-2) in murine splenic T lymphocytes.	Polysaccharides	33-47	interleukin 2	Mus musculus	68-81
14688088-10	2004	Furthermore, under the conditions we tested, PspA also inhibited C3 deposition when the classical pathway was initiated by antibodies to capsular polysaccharide.	Polysaccharides	146-160	surfactant associated protein A1	Mus musculus	45-49
14976987-2	2004	The binding interaction is mediated by GalNAc, presumably covalently attached to the APN as part of an undefined glycan structure.	Polysaccharides	113-119	alanyl aminopeptidase, membrane	Homo sapiens	85-88
14688097-2	2004	In this study, we determined the antibody response to and efficacy of P13, a peptide mimetic of the Cryptococcus neoformans capsular polysaccharide glucuronoxylomannan (GXM), in mice that produce human antibodies.	Polysaccharides	133-147	H3 histone pseudogene 6	Homo sapiens	70-73
14688121-4	2004	Sodium periodate-treated soluble extracts of both nematodes consistently induced significantly less IL-4 production than the respective mock-treated extracts, indicating that glycans play a critical role in the induction of the Th2 immune response by these nematodes.	Polysaccharides	175-182	interleukin 4	Mus musculus	100-104
14688121-5	2004	The glycan-dependent induction of the Th2-potentiating cytokine IL-4 occurs by 72 h postinoculation.	Polysaccharides	4-10	interleukin 4	Mus musculus	64-68
14976987-6	2004	We analyzed the various glycans on the 120 kDA APN using carbohydrate compositional analysis and lectin binding.	Polysaccharides	24-31	alanyl aminopeptidase, membrane	Homo sapiens	47-50
15021974-8	2004	In contrast, we found that the polysaccharide fucoidan reduced MPO and also improved skin flap survival.	Polysaccharides	31-45	myeloperoxidase	Rattus norvegicus	63-66
15021974-8	2004	In contrast, we found that the polysaccharide fucoidan reduced MPO and also improved skin flap survival.	Polysaccharides	31-45	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	90-94
15049070-1	2004	We studied the changes in lectin activity in tobacco leaf disc and potato tubers treated with polysaccharides (chitosan, glucomannan, and dextran sulfate), enzymes (cellulase and pectinase), or monosaccharides (glucose and glucosamine).	Polysaccharides	94-109	F-box protein PP2-B11-like	Nicotiana tabacum	26-32
15036307-5	2004	As a characteristic feature, a number of the latter glycans contained a Gal(beta1-6)Man-unit, which has not yet been found in glycoprotein-N-glycans.	Polysaccharides	52-59	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	76-83
15536626-8	2004	The proposed structures of several cross-ring cleavage ions were confirmed and it was shown that MS3 spectra could be obtained from as little as 10 fmol of glycan.	Polysaccharides	156-162	MS3	Homo sapiens	97-100
14561752-1	2003	A common glycan alteration in transformed cells and human tumors is the highly elevated levels of N-linked beta(1,6)glycans caused by increased transcription of N-acetylglucosaminyltransferase V (GnT-V).	Polysaccharides	9-15	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	161-194
15513317-9	2004	In Patient 23, the polysaccharide chain had sialic acid and was heat sensitive physicochemical properties that were similar to those of the Kasahara ALP variant.	Polysaccharides	19-33	alkaline phosphatase, placental	Homo sapiens	149-152
14519763-5	2003	We have demonstrated the feasibility of this new approach to rapidly assemble antithrombin III-binding classical and non-classical anticoagulant polysaccharide structures for the first time.	Polysaccharides	145-159	serpin family C member 1	Homo sapiens	78-94
14561752-1	2003	A common glycan alteration in transformed cells and human tumors is the highly elevated levels of N-linked beta(1,6)glycans caused by increased transcription of N-acetylglucosaminyltransferase V (GnT-V).	Polysaccharides	9-15	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	196-201
12952521-4	2003	The action of a deoxymannojirimycin- and kifunensine-sensitive alpha1,2-mannosidase was shown here to be required for both further glycan processing and progression of RI(332) in the ERAD pathway.	Polysaccharides	131-137	mannosidase alpha class 1A member 2	Homo sapiens	63-83
14685143-1	2003	PURPOSE: We have previously demonstrated that in RPE-deprived retinas, lactose, galactose, and structurally related glycans support the proper assembly of nascent photoreceptor outer segment membranes.	Polysaccharides	116-123	ribulose-5-phosphate-3-epimerase S homeolog	Xenopus laevis	49-52
14637158-13	2003	Furthermore, CD11b and/or CD18 partially mediated PL-induced DC maturation.	Polysaccharides	50-52	integrin alpha M	Mus musculus	13-18
14637158-13	2003	Furthermore, CD11b and/or CD18 partially mediated PL-induced DC maturation.	Polysaccharides	50-52	integrin beta 2	Mus musculus	26-30
14654234-3	2003	beta(1) integrin subunit from both cell lines displayed tri- and tetraantennary oligosaccharides complex type glycans, but only in A375 cell line was the sialylated tetraantennary complex type glycan (Hex(7)HexNAc(6)FucSia(4)) present.	Polysaccharides	110-117	integrin subunit beta 1	Homo sapiens	0-16
14654234-3	2003	beta(1) integrin subunit from both cell lines displayed tri- and tetraantennary oligosaccharides complex type glycans, but only in A375 cell line was the sialylated tetraantennary complex type glycan (Hex(7)HexNAc(6)FucSia(4)) present.	Polysaccharides	110-116	integrin subunit beta 1	Homo sapiens	0-16
14654234-5	2003	Our data indicate that the beta(1) and alpha(3) subunits expressed by the metastatic A375 cell line carry beta1-6 branched structures, suggesting that these cancer-associated glycan chains may modulate tumor cell adhesion by affecting the ligand binding properties of alpha(3)beta(1) integrin.	Polysaccharides	175-181	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	106-113
14654234-5	2003	Our data indicate that the beta(1) and alpha(3) subunits expressed by the metastatic A375 cell line carry beta1-6 branched structures, suggesting that these cancer-associated glycan chains may modulate tumor cell adhesion by affecting the ligand binding properties of alpha(3)beta(1) integrin.	Polysaccharides	175-181	integrin subunit beta 1	Homo sapiens	276-292
15033749-0	2003	The role of beta-glucuronidase in induction of apoptosis by genistein combined polysaccharide (GCP) in xenogeneic mice bearing human mammary cancer cells.	Polysaccharides	79-93	glucuronidase, beta	Mus musculus	12-30
14640600-7	2003	Analysis of cell wall polysaccharides size indicated that LeExp1 overexpression enhanced depolymerization of water soluble pectins as well as tightly bound matrix glycans.	Polysaccharides	22-37	expansin	Solanum lycopersicum	58-64
14640600-7	2003	Analysis of cell wall polysaccharides size indicated that LeExp1 overexpression enhanced depolymerization of water soluble pectins as well as tightly bound matrix glycans.	Polysaccharides	163-170	expansin	Solanum lycopersicum	58-64
14622259-3	2003	C1q can also bind nonimmune molecules such as DNA and sulfated polysaccharides, leading either to the activation or inhibition of Complement.	Polysaccharides	63-78	complement C1q A chain	Homo sapiens	0-3
14622259-10	2003	This binding property of fucoidan to C1q provides a mechanistic basis for the anticomplementary activity of the sulfated polysaccharide.	Polysaccharides	121-135	complement C1q A chain	Homo sapiens	37-40
14636953-0	2003	P-glycoprotein-mediated multidrug resistance phenotype of L1210/VCR cells is associated with decreases of oligo- and/or polysaccharide contents.	Polysaccharides	120-134	phosphoglycolate phosphatase	Mus musculus	0-14
14636836-0	2003	Toll-like receptor 4-dependent activation of macrophages by polysaccharide isolated from the radix of Platycodon grandiflorum.	Polysaccharides	60-74	toll-like receptor 4	Mus musculus	0-20
12952970-1	2003	Mucin glycans were isolated from different regions of the normal human intestine (ileum, cecum, transverse and sigmoid colon, and rectum) of two individuals with ALeb blood group.	Polysaccharides	6-13	LOC100508689	Homo sapiens	0-5
14719183-3	2003	To gain insight into structure-activity relationships, we investigated the interaction of a homogeneous series of sulfated polysaccharides, derived from controlled desulfation of a supersulfated low-molecular-weight heparin (LMWH) with the target enzymes human antithrombin (AT) and thrombin (T).	Polysaccharides	123-138	serpin family C member 1	Homo sapiens	261-273
14636953-8	2003	All the above facts indicate that multidrug resistance of L1210/VCR cells mediated predominantly by drug efflux activity of Pgp is accompanied by a considerable depression of oligo- and/or polysaccharides biosynthesis.	Polysaccharides	189-204	phosphoglycolate phosphatase	Mus musculus	124-127
14670733-3	2003	Degradation of the LPS in aqueous 1% acetic acid followed by GPC gave the O-antigenic polysaccharide, whose structure was determined by compositional analyses and NMR spectroscopy of the polysaccharide and O-deacylated polysaccharide as [carbohydrate structure: see text] where QuiN4N is 2,4-diamino-2,4,6-trideoxyglucose and GalNAcA 2-acetamido-2-deoxygalacturonic acid.	Polysaccharides	86-100	toll-like receptor 4	Mus musculus	19-22
14670733-3	2003	Degradation of the LPS in aqueous 1% acetic acid followed by GPC gave the O-antigenic polysaccharide, whose structure was determined by compositional analyses and NMR spectroscopy of the polysaccharide and O-deacylated polysaccharide as [carbohydrate structure: see text] where QuiN4N is 2,4-diamino-2,4,6-trideoxyglucose and GalNAcA 2-acetamido-2-deoxygalacturonic acid.	Polysaccharides	187-201	toll-like receptor 4	Mus musculus	19-22
14670733-3	2003	Degradation of the LPS in aqueous 1% acetic acid followed by GPC gave the O-antigenic polysaccharide, whose structure was determined by compositional analyses and NMR spectroscopy of the polysaccharide and O-deacylated polysaccharide as [carbohydrate structure: see text] where QuiN4N is 2,4-diamino-2,4,6-trideoxyglucose and GalNAcA 2-acetamido-2-deoxygalacturonic acid.	Polysaccharides	187-201	toll-like receptor 4	Mus musculus	19-22
14562394-1	2003	AIM: To study the effects of Rheum tanguticum polysaccharide(-1) (RTP(-1)) on ulcerative colitis in rats induced by 2, 4, 6-trinitrophene sulphonic acid (TNBS) and their possible mechanism.	Polysaccharides	46-60	receptor (chemosensory) transporter protein 1	Rattus norvegicus	66-72
14575696-6	2003	In fact, PF4 mechanism was competitive with respect to AT and non-competitive with respect to fXa, suggesting inhibition of important regulatory/catalytic interactions of fXa with the polysaccharide.	Polysaccharides	184-198	platelet factor 4	Homo sapiens	9-12
14575696-6	2003	In fact, PF4 mechanism was competitive with respect to AT and non-competitive with respect to fXa, suggesting inhibition of important regulatory/catalytic interactions of fXa with the polysaccharide.	Polysaccharides	184-198	coagulation factor X	Homo sapiens	171-174
14575696-7	2003	Altogether, the results suggested a model by which PF4 bound to proximal (but distinct) sites to AT, resulting in steric interference of fXa binding to both polysaccharide and AT.	Polysaccharides	157-171	platelet factor 4	Homo sapiens	51-54
14575696-7	2003	Altogether, the results suggested a model by which PF4 bound to proximal (but distinct) sites to AT, resulting in steric interference of fXa binding to both polysaccharide and AT.	Polysaccharides	157-171	coagulation factor X	Homo sapiens	137-140
14597733-3	2003	L-selectin counterreceptors in HEVs are recognized by mAb MECA-79, a surrogate marker for molecularly heterogeneous glycans termed peripheral node addressin.	Polysaccharides	116-123	selectin, lymphocyte	Mus musculus	0-10
14631106-0	2003	Carbohydrate structural units in glycoproteins and polysaccharides as important ligands for Gal and GalNAc reactive lectins.	Polysaccharides	51-66	galanin and GMAP prepropeptide	Homo sapiens	92-95
14629825-0	2003	Protective effects of a protein-bound polysaccharide, PSK, against Candida albicans infection in syngeneic tumor-bearing mice via Th1 cell functions.	Polysaccharides	38-52	TAO kinase 2	Mus musculus	54-57
14575696-0	2003	Platelet factor 4 neutralizes heparan sulfate-enhanced antithrombin inactivation of factor Xa by preventing interaction(s) of enzyme with polysaccharide.	Polysaccharides	138-152	platelet factor 4	Homo sapiens	0-17
14575696-0	2003	Platelet factor 4 neutralizes heparan sulfate-enhanced antithrombin inactivation of factor Xa by preventing interaction(s) of enzyme with polysaccharide.	Polysaccharides	138-152	serpin family C member 1	Homo sapiens	55-67
14575696-0	2003	Platelet factor 4 neutralizes heparan sulfate-enhanced antithrombin inactivation of factor Xa by preventing interaction(s) of enzyme with polysaccharide.	Polysaccharides	138-152	coagulation factor X	Homo sapiens	84-93
12799362-1	2003	An extracellular polysaccharide, AC-1, produced by Acetobacter polysaccharogenes is composed of beta-(1,4)glucan with branches of glucosyl residues.	Polysaccharides	17-31	adenylate cyclase 1	Mus musculus	33-37
14519947-3	2003	Pretreatment with PL 24 h before LPS administration resulted in a significant inhibition of up to 68% of circulating tumor necrosis factor (TNF)-alpha, a moderate reduction of 45% of interleukine (IL)-12 and 23% of IL-1beta, but no significant reduction in IL-6.	Polysaccharides	18-20	tumor necrosis factor	Mus musculus	117-150
14519947-3	2003	Pretreatment with PL 24 h before LPS administration resulted in a significant inhibition of up to 68% of circulating tumor necrosis factor (TNF)-alpha, a moderate reduction of 45% of interleukine (IL)-12 and 23% of IL-1beta, but no significant reduction in IL-6.	Polysaccharides	18-20	interleukin 1 beta	Mus musculus	215-223
14519947-3	2003	Pretreatment with PL 24 h before LPS administration resulted in a significant inhibition of up to 68% of circulating tumor necrosis factor (TNF)-alpha, a moderate reduction of 45% of interleukine (IL)-12 and 23% of IL-1beta, but no significant reduction in IL-6.	Polysaccharides	18-20	interleukin 6	Mus musculus	257-261
14519947-5	2003	Our results show that LPS-stimulated cytokine release and the level of MHC II can be modulated by in vivo administration of soluble PL in mice.	Polysaccharides	132-134	histocompatibility-2, MHC	Mus musculus	71-77
14519947-7	2003	Administration of PL in vivo decreases IL-2, IFN-gamma and TNF-alpha production in splencotyes and enhances spontaneous cell apoptosis in macrophages and lymphocytes stimulated with LPS in vitro.	Polysaccharides	18-20	interleukin 2	Mus musculus	39-43
14519947-7	2003	Administration of PL in vivo decreases IL-2, IFN-gamma and TNF-alpha production in splencotyes and enhances spontaneous cell apoptosis in macrophages and lymphocytes stimulated with LPS in vitro.	Polysaccharides	18-20	interferon gamma	Mus musculus	45-54
14519947-7	2003	Administration of PL in vivo decreases IL-2, IFN-gamma and TNF-alpha production in splencotyes and enhances spontaneous cell apoptosis in macrophages and lymphocytes stimulated with LPS in vitro.	Polysaccharides	18-20	tumor necrosis factor	Mus musculus	59-68
14519947-9	2003	The ability of PL to significantly reduce the TNF-alpha production indicates the potential of the polysaccharides in possible therapeutic strategies that are based on down-regulation of TNF-alpha.	Polysaccharides	98-113	tumor necrosis factor	Mus musculus	46-55
14519947-9	2003	The ability of PL to significantly reduce the TNF-alpha production indicates the potential of the polysaccharides in possible therapeutic strategies that are based on down-regulation of TNF-alpha.	Polysaccharides	98-113	tumor necrosis factor	Mus musculus	186-195
12946432-0	2003	Polysaccharide isolated from Poria cocos sclerotium induces NF-kappaB/Rel activation and iNOS expression in murine macrophages.	Polysaccharides	0-14	nitric oxide synthase 2, inducible	Mus musculus	89-93
12946432-1	2003	We show that PCSC, a polysaccharide isolated from the sclerotium of Poria cocos with 1% sodium carbonate, significantly induces nitric oxide (NO) production and inducible NO synthase (iNOS) transcription through the activation of nuclear factor-kappaB/Rel (NF-kappaB/Rel).	Polysaccharides	21-35	nitric oxide synthase 2, inducible	Mus musculus	184-188
12847092-3	2003	Like binding of P-selectin, binding of A. phagocytophilum to human neutrophils requires expression of P-selectin glycoprotein ligand-1 (PSGL-1) and alpha1-3-fucosyltransferases that construct the glycan determinant sialyl Lewis x (sLex).	Polysaccharides	196-202	selectin P ligand	Homo sapiens	102-134
14522939-2	2003	Through its glycan domains, endocan binds to hepatocyte growth factor and increases its mitogenic activity.	Polysaccharides	12-18	endothelial cell specific molecule 1	Homo sapiens	28-35
12851398-6	2003	PVL binding of asialo-sAP and its GPI-anchored glycan was diminished by digestion with diplococcal beta-N-acetylhexosaminidase or by mild acid treatment.	Polysaccharides	47-53	O-GlcNAcase	Homo sapiens	99-126
12946842-6	2003	Since the difference between the molecules derived from these two stages of the parasite growth cycle lies exclusively in the number of phosphosaccharide repeat domains and in the composition of glycan side chains that branch off these domains, we propose that TLR-2 possibly distinguishes between phosphorylated glycan repeats on LPG molecules.	Polysaccharides	313-319	toll like receptor 2	Homo sapiens	261-266
12941144-4	2003	Binding studies with glycoprotein (gp)120/gp41-positive and -negative virus preparations suggested that DC-SIGN and MBL bind primarily to glycans on gp120/gp41, as opposed to glycans on host-cell-derived proteins, indicating a close overlap in the binding site of the two lectins and supporting the notion that MBL could prevent binding of HIV to DC-SIGN.	Polysaccharides	138-145	mannose binding lectin 2	Homo sapiens	116-119
12946842-6	2003	Since the difference between the molecules derived from these two stages of the parasite growth cycle lies exclusively in the number of phosphosaccharide repeat domains and in the composition of glycan side chains that branch off these domains, we propose that TLR-2 possibly distinguishes between phosphorylated glycan repeats on LPG molecules.	Polysaccharides	195-201	toll like receptor 2	Homo sapiens	261-266
12837765-10	2003	Commercial heparin was found to be a powerful inhibitor (I50 approximately 20 nM expressed as disaccharide unit, approximately 0.7 nM polysaccharide) of heparanase action toward antithrombin-binding oligosaccharides.	Polysaccharides	134-148	serpin family C member 1	Homo sapiens	178-190
12837765-12	2003	These findings strongly suggest that the intracellular processing of the heparin proteoglycan polysaccharide chains is catalyzed by heparanase, which primarily cleaves target structures distinct from the antithrombin-binding sequence.	Polysaccharides	94-108	serpin family C member 1	Homo sapiens	204-216
12958180-4	2003	Carbohydrate analysis of the allergen revealed the presence of glycans carrying fucosyl and xylosyl residues, structures previously shown to bind IgE.	Polysaccharides	63-70	immunoglobulin heavy constant epsilon	Homo sapiens	146-149
14964446-7	2003	The presence of antibodies against the polysaccharide fraction of lateral chains of EPO has been observed only in patients treated with rhEPO.	Polysaccharides	39-53	erythropoietin	Homo sapiens	84-87
12920206-2	2003	Exogenous polysaccharides also modulate the angiogenic activity of FGF-2.	Polysaccharides	10-25	fibroblast growth factor 2	Homo sapiens	67-72
12791681-6	2003	Two other NCAM mutants, NCAM-6 (Ig1-5) and NCAM-7 (FN1-FN2), were weakly polysialylated by PST/ST8Sia IV, suggesting that a weaker enzyme recognition site may exist within the Ig domains, and that glycans in the FN region are polysialylated.	Polysaccharides	197-204	neural cell adhesion molecule 1	Homo sapiens	10-14
12791681-6	2003	Two other NCAM mutants, NCAM-6 (Ig1-5) and NCAM-7 (FN1-FN2), were weakly polysialylated by PST/ST8Sia IV, suggesting that a weaker enzyme recognition site may exist within the Ig domains, and that glycans in the FN region are polysialylated.	Polysaccharides	197-204	neural cell adhesion molecule 1	Homo sapiens	24-28
12791681-6	2003	Two other NCAM mutants, NCAM-6 (Ig1-5) and NCAM-7 (FN1-FN2), were weakly polysialylated by PST/ST8Sia IV, suggesting that a weaker enzyme recognition site may exist within the Ig domains, and that glycans in the FN region are polysialylated.	Polysaccharides	197-204	neural cell adhesion molecule 1	Homo sapiens	24-28
12791681-6	2003	Two other NCAM mutants, NCAM-6 (Ig1-5) and NCAM-7 (FN1-FN2), were weakly polysialylated by PST/ST8Sia IV, suggesting that a weaker enzyme recognition site may exist within the Ig domains, and that glycans in the FN region are polysialylated.	Polysaccharides	197-204	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	91-94
12791681-8	2003	Our data support a model in which the polysialyltransferases bind to the FN1 of NCAM to polymerize polysialic acid chains on appropriately presented glycans in adjacent regions.	Polysaccharides	149-156	fibronectin 1	Homo sapiens	73-76
12791681-8	2003	Our data support a model in which the polysialyltransferases bind to the FN1 of NCAM to polymerize polysialic acid chains on appropriately presented glycans in adjacent regions.	Polysaccharides	149-156	neural cell adhesion molecule 1	Homo sapiens	80-84
12859981-1	2003	Calcium spirulan (Ca-SP), a novel sulfated polysaccharide, increases the rate of thrombin inhibition by heparin cofactor II (HCII) more than 1000-fold through a mechanism not requiring the amino-terminal acidic domain of HCII.	Polysaccharides	43-57	coagulation factor II, thrombin	Homo sapiens	81-89
12859981-1	2003	Calcium spirulan (Ca-SP), a novel sulfated polysaccharide, increases the rate of thrombin inhibition by heparin cofactor II (HCII) more than 1000-fold through a mechanism not requiring the amino-terminal acidic domain of HCII.	Polysaccharides	43-57	serpin family D member 1	Homo sapiens	104-123
12859981-1	2003	Calcium spirulan (Ca-SP), a novel sulfated polysaccharide, increases the rate of thrombin inhibition by heparin cofactor II (HCII) more than 1000-fold through a mechanism not requiring the amino-terminal acidic domain of HCII.	Polysaccharides	43-57	serpin family D member 1	Homo sapiens	125-129
12736199-2	2003	Three glycan sequencing studies have identified O-linked mannose chains, including NeuAcalpha 2,3Galbeta 1,4GlcNAcbeta 1,2Manalpha-O, on alpha dystroglycan.	Polysaccharides	6-12	dystroglycan 1	Homo sapiens	143-155
12744721-8	2003	We conclude that under normal conditions the presence of the N9 glycan functions to maintain a folding rate for mucin monomers that is sufficiently slow to allow structural maturation and stability of Muc2 dimers.	Polysaccharides	64-70	solute carrier family 13 member 2	Rattus norvegicus	112-117
12744721-8	2003	We conclude that under normal conditions the presence of the N9 glycan functions to maintain a folding rate for mucin monomers that is sufficiently slow to allow structural maturation and stability of Muc2 dimers.	Polysaccharides	64-70	mucin 2, oligomeric mucus/gel-forming	Rattus norvegicus	201-205
12736199-3	2003	Chemical deglycosylation of alpha dystroglycan, antibody blocking studies, and glycan blocking studies all suggest that the O-linked glycans on alpha dystroglycan mediate the binding of extracellular matrix proteins in skeletal muscle.	Polysaccharides	40-46	dystroglycan 1	Homo sapiens	150-162
12906821-1	2003	A novel polysaccharide binding site is identified in domain C of barley alpha-amylase 1 from the X-ray structure of the enzyme/tetrasaccharide complex.	Polysaccharides	8-22	LOC548210	Hordeum vulgare	72-87
12864863-11	2003	Insertional mutations were constructed in pglE and pglF in N. meningitidis strain C311 musical sharp 3, a strain with well-defined lipopolysaccharide (LPS) and pilin-linked glycan structures.	Polysaccharides	173-179	NGO2041a	Neisseria gonorrhoeae FA 1090	160-165
12932360-6	2003	We propose the iterative anionic groups along the glycan backbone of the cell wall are a crucial structure for recognition by LBP.	Polysaccharides	50-56	lipopolysaccharide binding protein	Homo sapiens	126-129
12868606-1	2003	The fucosyltransferase gene family encodes enzymes that transfer fucose in alpha 1,2, alpha 1,3/4 and alpha 1,6 linkages on a large variety of glycans.	Polysaccharides	143-150	adrenoceptor alpha 1D	Homo sapiens	75-111
12847256-8	2003	Our results show that the stalk region of CD8beta is capable of fine-tuning the coreceptor function of CD8 proteins as a coreceptor, possibly due to its distinct protein structure, smaller physical size and the unique glycan adducts associated with this region.	Polysaccharides	218-224	CD8b molecule	Homo sapiens	42-49
12847256-8	2003	Our results show that the stalk region of CD8beta is capable of fine-tuning the coreceptor function of CD8 proteins as a coreceptor, possibly due to its distinct protein structure, smaller physical size and the unique glycan adducts associated with this region.	Polysaccharides	218-224	CD8a molecule	Homo sapiens	42-45
12672704-4	2003	N-glycans were released from the purified recombinant human serum transferrin and derivatized with 2-aminopyridine; the glycan structures were analyzed by a two-dimensional HPLC and MALDI-TOF MS.	Polysaccharides	2-8	transferrin	Homo sapiens	66-77
12672481-5	2003	The lower level of binding of the AChE monomers with WGA (55-60%), and especially with RCA (10-15%), with respect to the dimers, reflected heterogeneity in the sugar composition of the glycans linked to each AChE subunit in dimers.	Polysaccharides	185-192	acetylcholinesterase	Mus musculus	34-38
12837600-4	2003	The high resolving power of the quadrupole TOF instrument results in the selective detection of glycan specific fragment ions minimizing the interference of peptide derived fragment ions with the same nominal mass.	Polysaccharides	96-102	FEZ family zinc finger 2	Homo sapiens	43-46
12837954-2	2003	The mur3 mutant of Arabidopsis contains a severely altered structure of this polysaccharide because of the absence of a conserved alpha-L-fucosyl-(1--&gt;2)-beta-D-galactosyl side chain and excessive galactosylation at an alternative xylose residue.	Polysaccharides	77-91	Exostosin family protein	Arabidopsis thaliana	4-8
12787029-4	2003	The major glycans of squid rhodopsin were shown to possess the alpha1-3 and alpha1-6 difucosylated innermost GlcNAc residue found in glycoproteins produced by insects and helminths.	Polysaccharides	10-17	rhodopsin	Homo sapiens	27-36
12794829-1	2003	OBJECTIVE: CD22, a B cell-restricted transmembrane glycoprotein, regulates B cell antigen receptor signaling upon interaction with alpha2,6-linked sialic acid-bearing glycans, which act as ligands and are expressed on B and T cells.	Polysaccharides	167-174	CD22 antigen	Mus musculus	11-15
12805210-0	2003	Role of calnexin in the glycan-independent quality control of proteolipid protein.	Polysaccharides	24-30	calnexin	Homo sapiens	8-16
12805210-6	2003	Notably, this glycan-independent interaction with calnexin significantly retards the degradation of misfolded PLP.	Polysaccharides	14-20	calnexin	Homo sapiens	50-58
12805210-6	2003	Notably, this glycan-independent interaction with calnexin significantly retards the degradation of misfolded PLP.	Polysaccharides	14-20	proteolipid protein 1	Homo sapiens	110-113
12794146-2	2003	Capsule-specific IgG1 and IgG2 Abs are induced upon vaccination with polysaccharide-based vaccines that mediate host protection.	Polysaccharides	69-83	LOC105243590	Mus musculus	17-21
12783566-0	2003	Imaging structured water and bound polysaccharide on mica surface at ambient temperature.	Polysaccharides	35-49	MHC class I polypeptide-related sequence A	Homo sapiens	53-57
12808284-0	2003	Interaction of protein-bound polysaccharide (PSK) with smooth muscle myosin regulatory light chain.	Polysaccharides	29-43	TAO kinase 2	Homo sapiens	45-48
12808284-1	2003	The interaction of a protein-bound polysaccharide (PSK) isolated from Basidiomycetes with smooth muscle myosin components was evaluated by limited digestion, urea/glycerol gel electrophoresis, affinity chromatography and overlay assay using a peptide array.	Polysaccharides	35-49	TAO kinase 2	Homo sapiens	51-54
12829373-2	2003	The N-glycans were released from PVDF-blotted HSA or CD24 and separated on Carbograph SPE into neutral and acid glycans.	Polysaccharides	6-13	CD24a antigen	Mus musculus	53-57
12818213-8	2003	The polysaccharide treatment significantly reduced the production of IL-4 and IL-10 following cryoablation; the production of TNF-alpha and INF-gamma was slightly promoted; the natural killer and cytotoxic T-cell activities of splenocytes were slightly enhanced.	Polysaccharides	4-18	interleukin 4	Mus musculus	69-73
12818213-8	2003	The polysaccharide treatment significantly reduced the production of IL-4 and IL-10 following cryoablation; the production of TNF-alpha and INF-gamma was slightly promoted; the natural killer and cytotoxic T-cell activities of splenocytes were slightly enhanced.	Polysaccharides	4-18	interleukin 10	Mus musculus	78-83
12818213-9	2003	It was concluded that the polysaccharide preparation was beneficial by suppressing IL-4 and IL-10 production and might inhibit the growth of residual tumor that is sometimes induced by large-volume cryoablation.	Polysaccharides	26-40	interleukin 4	Mus musculus	83-87
12818213-9	2003	It was concluded that the polysaccharide preparation was beneficial by suppressing IL-4 and IL-10 production and might inhibit the growth of residual tumor that is sometimes induced by large-volume cryoablation.	Polysaccharides	26-40	interleukin 10	Mus musculus	92-97
12787029-4	2003	The major glycans of squid rhodopsin were shown to possess the alpha1-3 and alpha1-6 difucosylated innermost GlcNAc residue found in glycoproteins produced by insects and helminths.	Polysaccharides	10-17	adrenoceptor alpha 1D	Homo sapiens	63-84
12758164-10	2003	The GGT glycans from the two colon carcinoma cell lines also possessed these features.	Polysaccharides	8-15	gamma-glutamyltransferase light chain family member 3	Homo sapiens	4-7
12626390-5	2003	Glycans from normal PSA (that correspond to low and high pI PSA fractions) were sialylated biantennary complex structures, half of them being disialylated in the low pI PSA fraction and mostly monosialylated in the high pI PSA.	Polysaccharides	0-7	kallikrein related peptidase 3	Homo sapiens	20-23
12626390-5	2003	Glycans from normal PSA (that correspond to low and high pI PSA fractions) were sialylated biantennary complex structures, half of them being disialylated in the low pI PSA fraction and mostly monosialylated in the high pI PSA.	Polysaccharides	0-7	kallikrein related peptidase 3	Homo sapiens	60-63
12626390-5	2003	Glycans from normal PSA (that correspond to low and high pI PSA fractions) were sialylated biantennary complex structures, half of them being disialylated in the low pI PSA fraction and mostly monosialylated in the high pI PSA.	Polysaccharides	0-7	kallikrein related peptidase 3	Homo sapiens	60-63
12626390-5	2003	Glycans from normal PSA (that correspond to low and high pI PSA fractions) were sialylated biantennary complex structures, half of them being disialylated in the low pI PSA fraction and mostly monosialylated in the high pI PSA.	Polysaccharides	0-7	kallikrein related peptidase 3	Homo sapiens	60-63
12626390-6	2003	PSA from LNCaP cells was purified to homogeneity, and its glycan analysis showed a significantly different pattern, especially in the outer ends of the biantennary complex structures.	Polysaccharides	58-64	kallikrein related peptidase 3	Homo sapiens	0-3
12678821-3	2003	Major ligands of E-selectin, the selectin family member expressed on vascular endothelial cells, include sialylated, fucosylated glycans such as Sialyl Lewis type carbohydrate complexes (SLe(x) and SLe(a)).	Polysaccharides	129-136	selectin E	Homo sapiens	17-27
12948833-2	2003	This polysaccharide also exhibits hemorrhagic tendency mediated by the inhibition of thrombin in heparinotherapy.	Polysaccharides	5-19	coagulation factor II, thrombin	Homo sapiens	85-93
12731049-1	2003	CD25(+) suppressor T cells regulate the immune response against the type-2 "thymus independent" bacterial polysaccharide antigen alpha(1--&gt;3)dextran (Dex) in BALB/c mice.	Polysaccharides	106-120	interleukin 2 receptor, alpha chain	Mus musculus	0-4
12637583-3	2003	Based on these data, we have constructed a molecular model of SIgA1 with all its glycans, in which the Fab arms form a T shape and the SC is wrapped around the heavy chains.	Polysaccharides	81-88	FA complementation group B	Homo sapiens	103-106
12637583-4	2003	The O-glycan regions on the heavy (H) chains and the SC N-glycans have adhesin-binding glycan epitopes including galactose-linked beta1-4 and beta1-3 to GlcNAc, fucose-linked alpha1-3 and alpha1-4 to GlcNAc and alpha1-2 to galactose, and alpha2-3 and alpha2-6-linked sialic acids.	Polysaccharides	6-12	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	142-149
12637583-4	2003	The O-glycan regions on the heavy (H) chains and the SC N-glycans have adhesin-binding glycan epitopes including galactose-linked beta1-4 and beta1-3 to GlcNAc, fucose-linked alpha1-3 and alpha1-4 to GlcNAc and alpha1-2 to galactose, and alpha2-3 and alpha2-6-linked sialic acids.	Polysaccharides	6-12	adrenoceptor alpha 1D	Homo sapiens	161-196
12637583-4	2003	The O-glycan regions on the heavy (H) chains and the SC N-glycans have adhesin-binding glycan epitopes including galactose-linked beta1-4 and beta1-3 to GlcNAc, fucose-linked alpha1-3 and alpha1-4 to GlcNAc and alpha1-2 to galactose, and alpha2-3 and alpha2-6-linked sialic acids.	Polysaccharides	6-12	adrenoceptor alpha 1D	Homo sapiens	211-219
12637583-4	2003	The O-glycan regions on the heavy (H) chains and the SC N-glycans have adhesin-binding glycan epitopes including galactose-linked beta1-4 and beta1-3 to GlcNAc, fucose-linked alpha1-3 and alpha1-4 to GlcNAc and alpha1-2 to galactose, and alpha2-3 and alpha2-6-linked sialic acids.	Polysaccharides	6-12	immunoglobulin binding protein 1	Homo sapiens	251-259
12599258-7	2003	The rates of ectoenzyme-mediated polysaccharide (alpha-glucosidase) and protein (leucine aminopeptidase) hydrolysis became relatively constant once pollutant removal efficiency stabilized.	Polysaccharides	33-47	sucrase-isomaltase	Homo sapiens	49-66
12637583-5	2003	These glycan epitopes provide SIgA with further bacteria-binding sites in addition to the four Fab-binding sites, thus enabling SIgA to participate in both innate and adaptive immunity.	Polysaccharides	6-12	FA complementation group B	Homo sapiens	95-98
12757930-5	2003	Low levels of endogenous TIMP3 protein expression were elevated using the natural polysaccharide calcium pentosan polysulfate (CaPPs) in combination with the cytokine IL-1alpha.	Polysaccharides	82-96	TIMP metallopeptidase inhibitor 3	Homo sapiens	25-30
12706968-0	2003	First synthesis of beta-D-Galf-(1--&gt;3)-D-Galp--the repeating unit of the backbone structure of the O-antigenic polysaccharide present in the lipopolysaccharide (LPS) of the genus Klebsiella.	Polysaccharides	114-128	galanin like peptide	Homo sapiens	44-48
12731052-6	2003	During murine infection, these complex-type N-glycans induce a glycan-specific Th2 cellular response and elicit T-dependent anti-core alpha 3-fucose and anti-core beta 2-xylose IgG1 (a Th2-associated isotype), but not IgG2b (a Th1-associated isotype) Ab.	Polysaccharides	46-52	immunoglobulin heavy constant gamma 2B	Mus musculus	218-223
12687011-3	2003	PSK, a protein-bound polysaccharide, is widely used in Japan as an immunopotentiating biological response modifier for cancer patients.	Polysaccharides	21-35	TAO kinase 2	Homo sapiens	0-3
12689824-2	2003	An affinity capillary electrophoresis method has been developed to evidence the complex formation and to determine the binding properties between an anticoagulant polysaccharide of marine origin, fucoidan, and a potential target protein, antithrombin.	Polysaccharides	163-177	serpin family C member 1	Homo sapiens	238-250
12689824-5	2003	The effective mobility data of the protein were processed according to classical linearization treatments to obtain the binding constant for the polysaccharide/antithrombin complex.	Polysaccharides	145-159	serpin family C member 1	Homo sapiens	160-172
12689824-6	2003	The results indicate that fucoidan binds to antithrombin in a 1:1 stoichiometry and with an affinity depending on the molecular weight of the polysaccharide.	Polysaccharides	142-156	serpin family C member 1	Homo sapiens	44-56
12735687-0	2003	The polysaccharide fraction AIP1 from Artemisia iwayomogi suppresses apoptotic death of the mouse spleen cells in culture.	Polysaccharides	4-18	membrane associated guanylate kinase, WW and PDZ domain containing 2	Mus musculus	28-32
12742574-2	2003	The three polysaccharides effectively inhibited the replication of III(B) in PBLs and of BaL in MACs, while producing either a slight inhibition or an unexpected large increase in the replication of the seven primary isolates, especially in MAC cultures.	Polysaccharides	10-25	poly(ADP-ribose) polymerase family member 9	Homo sapiens	89-92
12735687-1	2003	A polysaccharide fraction, AIP1, purified from Artemisia iwayomogi was shown to have immunomodulating and anti-tumor activities in mice.	Polysaccharides	2-16	membrane associated guanylate kinase, WW and PDZ domain containing 2	Mus musculus	27-31
12588858-7	2003	Re-introduction of Tollo/Toll-8 into null embryos rescues neural-specific glycan expression.	Polysaccharides	74-80	tollo	Drosophila melanogaster	19-31
12626415-2	2003	RNase 1 from healthy cells contained neutral complex biantennary structures, with smaller amounts of tri- and tetraantennary compounds, and glycans with poly-N-acetyllactosamine extensions, all extensively fucosylated.	Polysaccharides	140-147	ribonuclease A family member 1, pancreatic	Homo sapiens	0-7
12671684-2	2003	UDP-glucose glycoprotein:glucosyltransferase (UGGT) is the sensor component of the calnexin cycle, which recognizes these glycoproteins when they are incompletely folded, and transfers a glucose residue from UDP-glucose to N-linked Man9-GlcNAc2 glycans.	Polysaccharides	245-252	calnexin	Homo sapiens	83-91
12671684-2	2003	UDP-glucose glycoprotein:glucosyltransferase (UGGT) is the sensor component of the calnexin cycle, which recognizes these glycoproteins when they are incompletely folded, and transfers a glucose residue from UDP-glucose to N-linked Man9-GlcNAc2 glycans.	Polysaccharides	245-252	mannosidase alpha class 1A member 1	Homo sapiens	232-236
12626415-3	2003	In contrast, RNase 1 glycans from tumor cells (Capan-1) were fucosylated hybrid and complex biantennary glycans with GalNAc-GlcNAc antennae.	Polysaccharides	21-28	ribonuclease A family member 1, pancreatic	Homo sapiens	13-20
12626415-4	2003	RNase 1 glycans from Capan-1 and MDAPanc-3 cells also contained sialylated structures completely absent in the healthy pancreas.	Polysaccharides	8-15	ribonuclease A family member 1, pancreatic	Homo sapiens	0-7
12631291-10	2003	By application of MALDI-TOF mass spectrometry the predominant glycan structure of the natural allergen was identified as MMXF (Man alpha 1-6(Man alpha 1-3)(Xyl beta 1-2)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-3) GlcNAc).	Polysaccharides	62-68	adrenoceptor alpha 1D	Homo sapiens	131-140
12511560-1	2003	Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.	Polysaccharides	46-53	beta-1,4-galactosyltransferase 5	Homo sapiens	0-13
12511560-1	2003	Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.	Polysaccharides	46-52	beta-1,4-galactosyltransferase 5	Homo sapiens	0-13
12629225-5	2003	In normal mice, Hp1 has tropism for a parietal cell-deficient niche where sialylated glycans are expressed by a narrow band of pit cells positioned at the boundary between the squamous epithelium (forestomach) and the proximal glandular epithelium.	Polysaccharides	85-92	chromobox 5	Mus musculus	16-19
12820689-1	2003	The role of glycan moieties in thyrotropin receptor molecule in binding of antibodies is a subject of intense debate.	Polysaccharides	12-18	thyroid stimulating hormone receptor	Homo sapiens	31-51
12600949-10	2003	CONCLUSIONS: The urinary data support the concept that the inherited defect of the ABCC6/MRP6 transporter in PXE alters metabolism of key polysaccharides.	Polysaccharides	138-153	ATP binding cassette subfamily C member 6	Homo sapiens	83-88
12600949-10	2003	CONCLUSIONS: The urinary data support the concept that the inherited defect of the ABCC6/MRP6 transporter in PXE alters metabolism of key polysaccharides.	Polysaccharides	138-153	ATP binding cassette subfamily C member 6	Homo sapiens	89-93
12631291-10	2003	By application of MALDI-TOF mass spectrometry the predominant glycan structure of the natural allergen was identified as MMXF (Man alpha 1-6(Man alpha 1-3)(Xyl beta 1-2)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-3) GlcNAc).	Polysaccharides	62-68	adrenoceptor alpha 1D	Homo sapiens	145-154
12631291-10	2003	By application of MALDI-TOF mass spectrometry the predominant glycan structure of the natural allergen was identified as MMXF (Man alpha 1-6(Man alpha 1-3)(Xyl beta 1-2)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-3) GlcNAc).	Polysaccharides	62-68	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	160-168
12631291-10	2003	By application of MALDI-TOF mass spectrometry the predominant glycan structure of the natural allergen was identified as MMXF (Man alpha 1-6(Man alpha 1-3)(Xyl beta 1-2)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-3) GlcNAc).	Polysaccharides	62-68	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	160-166
12631291-10	2003	By application of MALDI-TOF mass spectrometry the predominant glycan structure of the natural allergen was identified as MMXF (Man alpha 1-6(Man alpha 1-3)(Xyl beta 1-2)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-3) GlcNAc).	Polysaccharides	62-68	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	173-179
12631291-10	2003	By application of MALDI-TOF mass spectrometry the predominant glycan structure of the natural allergen was identified as MMXF (Man alpha 1-6(Man alpha 1-3)(Xyl beta 1-2)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-3) GlcNAc).	Polysaccharides	62-68	adrenoceptor alpha 1D	Homo sapiens	201-210
12722924-11	2003	Based on the biochemical process together with the present results, GAPDH and endothelin-1 immunoreactivity is associated with this damage and the mismetabolism of polysaccharides caused by CAG triplet elongation on chromosome 12p may contribute to the formation of the cerebral white matter damage in DRPLA.	Polysaccharides	164-179	atrophin 1	Homo sapiens	302-307
12626416-1	2003	The glycan moiety of human recombinant gonadotrophins (r-hFSH, r-hLH, and r-hCG) produced in CHO cell lines has been characterized by a combination of chromatographic and mass spectrometric techniques, including both matrix-assisted laser desorption ionization and electrospray.	Polysaccharides	4-10	Rh family C glycoprotein	Homo sapiens	74-79
12603841-8	2003	We therefore report that the two conserved ligand-binding domain glycans do not play any major role in receptor-ligand interactions, do not impart a stabilizing effect on the ligand-binding domain, and are not critical for the formation and surface localization of homomeric GluR-D AMPA receptors in HEK293 cells.	Polysaccharides	65-72	glutamate ionotropic receptor AMPA type subunit 4	Homo sapiens	275-281
12560137-1	2003	We have previously found that oral or intravenous administration of PC-2, a polysaccharide fraction purified from extracts of lichen Flavoparmelia caperata, facilitates the induction of long-term potentiation (LTP) in the dentate gyrus of anesthetized rats.	Polysaccharides	76-90	proprotein convertase subtilisin/kexin type 2	Rattus norvegicus	68-72
12560052-5	2003	In the present study the molecular interactions between the NaPPS, ChSs and some other sulfated polysaccharides with immobilized HNE, HAase or lysozyme (a cationic protein implicated in PG metabolism) were studied using a SPR biosensor device-BIAcore2000.	Polysaccharides	96-111	elastase, neutrophil expressed	Homo sapiens	129-132
12538765-1	2003	O-linked GlcNAc transferase (OGT) mediates a novel glycan-dependent signaling pathway, but the intracellular targeting of OGT is poorly understood.	Polysaccharides	51-57	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	0-27
12538765-1	2003	O-linked GlcNAc transferase (OGT) mediates a novel glycan-dependent signaling pathway, but the intracellular targeting of OGT is poorly understood.	Polysaccharides	51-57	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	29-32
12574364-2	2003	Previous studies have implicated T cells in the pathogenesis of abscess formation, and we have recently shown that CD4(+) T cells activated in vitro by zwitterionic capsular polysaccharides from abscess-inducing bacteria such as Staphylococcus aureus and Bacteroides fragilis initiate this host response when transferred to naive rats.	Polysaccharides	174-189	CD4 antigen	Mus musculus	115-118
12560052-8	2003	The inhibition of HNE by the sulfated polysaccharides as determined using the synthetic substrate succinyl-Ala-Ala-Val-nitroanilide (SAAVNA) in a functional assay was compared with their respective binding affinities for this proteinase using the BIAcore system.	Polysaccharides	38-53	elastase, neutrophil expressed	Homo sapiens	18-21
12560052-10	2003	The observed difference in order of binding affinities of the drugs to the immobilized HNE, HAase and lysozyme suggests a conformational relationship, in addition to the charge interactions between the sulfate esters of the polysaccharides and the cationic amino acids of the enzymes.	Polysaccharides	224-239	elastase, neutrophil expressed	Homo sapiens	87-90
12683633-3	2003	It is thus a sulfated polysaccharide with a molecular mass of about 424 kDa, and is designated SP-2a.	Polysaccharides	22-36	surfactant protein A2	Homo sapiens	95-100
12562324-0	2003	Roles for CD40, B7 and major histocompatibility complex in induction of enhanced immunity by cryptococcal polysaccharide-pulsed antigen-presenting cells.	Polysaccharides	106-120	CD40 antigen	Mus musculus	10-14
12594234-1	2003	alpha1,4-N-acetylglucosaminyltransferase (alpha4GnT) is a glycosyltransferase that forms a unique glycan, GlcNAcalpha1--&gt;4Galbeta--&gt;R, specifically present in gastric gland mucous cell-type mucin.	Polysaccharides	98-104	alpha-1,4-N-acetylglucosaminyltransferase	Homo sapiens	0-40
12533454-1	2003	The rmpA2 gene, which encodes an activator for capsular polysaccharide (CPS) synthesis, was isolated from a 200-kb virulence plasmid of Klebsiella pneumoniae CG43.	Polysaccharides	56-70	regulator of mucoid phenotype	Klebsiella pneumoniae CG43	4-9
12558975-7	2003	A striking homology between the first immunoglobulin (Ig)-like domain of basigin and the fourth Ig-like domain of NCAM, previously shown to bind to oligomannosidic glycans, and the lectin domain of the mannose receptor confirms that basigin is an oligomannose binding lectin.	Polysaccharides	164-171	basigin	Mus musculus	73-80
12558975-7	2003	A striking homology between the first immunoglobulin (Ig)-like domain of basigin and the fourth Ig-like domain of NCAM, previously shown to bind to oligomannosidic glycans, and the lectin domain of the mannose receptor confirms that basigin is an oligomannose binding lectin.	Polysaccharides	164-171	neural cell adhesion molecule 1	Mus musculus	114-118
12594234-1	2003	alpha1,4-N-acetylglucosaminyltransferase (alpha4GnT) is a glycosyltransferase that forms a unique glycan, GlcNAcalpha1--&gt;4Galbeta--&gt;R, specifically present in gastric gland mucous cell-type mucin.	Polysaccharides	98-104	alpha-1,4-N-acetylglucosaminyltransferase	Homo sapiens	42-51
12566589-3	2003	Enzyme assays of MUR4 protein expressed in the methylotropic yeast Pichia pastoris indicate that it catalyzes the 4-epimerization of UDP-D-Xyl to UDP-L-Ara, the nucleotide sugar used by glycosyltransferases in the arabinosylation of cell wall polysaccharides and wall-resident proteoglycans.	Polysaccharides	243-258	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	17-21
12701754-0	2003	Galectin-3, an endogenous lectin, as a tool for monitoring cell differentiation in head and neck carcinomas with implications for lectin-glycan functionality.	Polysaccharides	137-143	galectin 3	Homo sapiens	0-10
12586879-8	2003	AtCSLA7 is widely expressed, and is likely to be required for synthesis of a cell wall polysaccharide found throughout the plant.	Polysaccharides	87-101	cellulose synthase like	Arabidopsis thaliana	0-7
12795218-0	2003	[Structural features of two neutral polysaccharides Md-1, Md-2 from Ophiopogon japonocus].	Polysaccharides	36-51	MAFD1	Homo sapiens	52-56
12795218-0	2003	[Structural features of two neutral polysaccharides Md-1, Md-2 from Ophiopogon japonocus].	Polysaccharides	36-51	lymphocyte antigen 96	Homo sapiens	58-62
12795218-6	2003	CONCLUSION: Md-1 and Md-2 polysaccharides are glucosans, which only are composed of D-glucose units joined by alpha-(1--&gt;4) glucosidic linkages.	Polysaccharides	26-41	lymphocyte antigen 96	Homo sapiens	21-25
12701754-1	2003	OBJECTIVE: Galectin-3 is an endogenous lectin that reacts with glycan epitopes of membrane and extracellular glycoproteins, including integrins, fibronectin, laminin and tetraspanins.	Polysaccharides	63-69	galectin 3	Homo sapiens	11-21
12723751-0	2003	Effect of polysaccharide Krestin on the up-regulation of macrophage colony-stimulating factor gene expression in protecting mouse peritoneal macrophages from oxidative injury.	Polysaccharides	10-24	colony stimulating factor 1 (macrophage)	Mus musculus	57-93
12765778-5	2003	The results were interpreted in terms of a binding site for antithrombin constituted by a pentasaccharide sequence with an internal unique 3-O-sulfated glucosamine unit, in addition to sugar residues and sulfate groups present elsewhere also in the polysaccharide.	Polysaccharides	249-263	serpin family C member 1	Homo sapiens	60-72
12496386-0	2003	Impaired antibody response to group B streptococcal type III capsular polysaccharide in C3- and complement receptor 2-deficient mice.	Polysaccharides	70-84	complement component 3	Mus musculus	88-117
14570155-0	2003	Sulfated polysaccharides of brown seaweed Cystoseira canariensis bind to serum myostatin protein.	Polysaccharides	9-24	myostatin	Homo sapiens	79-88
14582617-6	2003	These include denaturation of lysozyme, modification of lysozyme by covalent attachment of polysaccharides, fatty acids and other compounds, attachment of C-terminal hydrophobic peptides to lysozyme by genetic modification, and the use of outer membrane permeabilizing agents such as EDTA or polycations or permeabilizing treatments such as high hydrostatic pressure treatment.	Polysaccharides	91-106	lysozyme	Homo sapiens	56-64
14582617-6	2003	These include denaturation of lysozyme, modification of lysozyme by covalent attachment of polysaccharides, fatty acids and other compounds, attachment of C-terminal hydrophobic peptides to lysozyme by genetic modification, and the use of outer membrane permeabilizing agents such as EDTA or polycations or permeabilizing treatments such as high hydrostatic pressure treatment.	Polysaccharides	91-106	lysozyme	Homo sapiens	56-64
12496166-0	2003	4-1BB (CD137) differentially regulates murine in vivo protein- and polysaccharide-specific immunoglobulin isotype responses to Streptococcus pneumoniae.	Polysaccharides	67-81	tumor necrosis factor receptor superfamily, member 9	Mus musculus	0-5
12496166-0	2003	4-1BB (CD137) differentially regulates murine in vivo protein- and polysaccharide-specific immunoglobulin isotype responses to Streptococcus pneumoniae.	Polysaccharides	67-81	tumor necrosis factor receptor superfamily, member 9	Mus musculus	7-12
12496166-10	2003	These data are the first to suggest a stimulatory role for endogenous 4-1BB-4-1BBL interactions during a humoral immune response to a pathogen and further underscore significant differences in costimulation requirements for an in vivo protein- versus polysaccharide-specific Ig isotype response to an extracellular bacterium.	Polysaccharides	251-265	tumor necrosis factor receptor superfamily, member 9	Mus musculus	70-75
12496166-10	2003	These data are the first to suggest a stimulatory role for endogenous 4-1BB-4-1BBL interactions during a humoral immune response to a pathogen and further underscore significant differences in costimulation requirements for an in vivo protein- versus polysaccharide-specific Ig isotype response to an extracellular bacterium.	Polysaccharides	251-265	tumor necrosis factor (ligand) superfamily, member 9	Mus musculus	76-82
14970705-7	2003	The screening of a major part of the PRKAG3 coding sequence in a small case/control material of horses affected with polysaccharide storage myopathy did not reveal any mutation that was exclusively associated with this muscle storage disease.	Polysaccharides	117-131	protein kinase AMP-activated non-catalytic subunit gamma 3	Equus caballus	37-43
12634318-5	2003	Both NDST-1 and -2 N-deacetylate heparan sulfate from human aorta ( approximately 0.6 sulfate groups/disaccharide) with comparable high efficiency, apparent Km values of 0.35 and 0.76 microM (calculation based on [HexA]) being lower (representing a higher affinity) than those for K5 polysaccharide (13.3 and 4.7 microM, respectively).	Polysaccharides	284-298	N-deacetylase and N-sulfotransferase 1	Homo sapiens	5-18
12634321-4	2003	Detailed analyses by MALDI-TOF MS, exoglycosidase digestion, and two-dimensional HPLC revealed that the N-glycans on the purified recombinant human transferrin produced by this virus-host system included four different fully galactosylated, biantennary, complex-type glycans.	Polysaccharides	106-113	transferrin	Homo sapiens	148-159
12620379-8	2003	Therefore, as all milk samples contained antibodies to capsular polysaccharide type 5 and to other surface antigens, it is likely that milk antibodies were responsible for these two phagocytic events.	Polysaccharides	64-78	Weaning weight-maternal milk	Bos taurus	135-139
14579587-3	2003	This chapter focused on two applications in which SPR has been used to map conformational epitopes on bacterial polysaccharides recognized by protective antibodies.	Polysaccharides	112-127	sepiapterin reductase	Homo sapiens	50-53
12925914-1	2003	The structure of a sulfated polysaccharide (B-1) isolated and purified from the culture filtrate of marine Pseudomonas sp.	Polysaccharides	28-42	immunoglobulin kappa variable 7-3 (pseudogene)	Homo sapiens	44-47
12490404-9	2002	Our data demonstrate that V3 glycans play an important role in the usage of CXCR4 and CCR5.	Polysaccharides	29-36	C-X-C motif chemokine receptor 4	Homo sapiens	76-81
12489987-9	2002	CONCLUSION: Our present observations underscore a role for glycans present on the CXCR4 coreceptor in the entry process of HIV-1.	Polysaccharides	59-66	C-X-C motif chemokine receptor 4	Homo sapiens	82-87
12393554-10	2002	These data suggest that murine myeloid leukocytes fucosylate only a few specific glycans, which interact preferentially with P- and E-selectin.	Polysaccharides	81-88	selectin, endothelial cell	Mus musculus	132-142
12417409-1	2002	UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I) and UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II (GnT II) are key enzymes in the synthesis of Asn-linked hybrid and complex glycans.	Polysaccharides	262-269	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	88-93
12490404-9	2002	Our data demonstrate that V3 glycans play an important role in the usage of CXCR4 and CCR5.	Polysaccharides	29-36	C-C motif chemokine receptor 5	Homo sapiens	86-90
12490404-11	2002	This study also demonstrates that glycan g15 is involved in blocking of neutralizing antibodies and shifting HIV tropism from R5X4 to X4.	Polysaccharides	34-40	RNA binding motif protein 5	Homo sapiens	41-44
12466127-8	2002	Furthermore, TGF-beta1 added to SAVIC cultures increased the production of sulfated glycan and hyaluronic acid.	Polysaccharides	84-90	transforming growth factor beta-1 proprotein	Ovis aries	13-22
12452837-0	2002	Inflammatory cytokine (interleukin 6 and tumour necrosis factor alpha) release in a human whole blood system in response to Streptococcus pneumoniae serotype 14 and its capsular polysaccharide.	Polysaccharides	178-192	interleukin 6	Homo sapiens	23-69
12472685-8	2002	For tpt-1/sex1 combining a lack in the TPT with a deficiency in starch mobilisation, an additional compensatory mechanism emerged, i.e. the formation and (most likely) fast turnover of high molecular weight polysaccharides.	Polysaccharides	207-222	homogentisate phytyltransferase 1	Arabidopsis thaliana	4-9
15144015-7	2002	We speculate that the expression of CD90 on neonatal MZ-B cells may have implications for their responsiveness to polysaccharide (T cell-independent type 2) antigens.	Polysaccharides	114-128	Thy-1 cell surface antigen	Rattus norvegicus	36-40
12472685-8	2002	For tpt-1/sex1 combining a lack in the TPT with a deficiency in starch mobilisation, an additional compensatory mechanism emerged, i.e. the formation and (most likely) fast turnover of high molecular weight polysaccharides.	Polysaccharides	207-222	Pyruvate phosphate dikinase, PEP/pyruvate binding domain-containing protein	Arabidopsis thaliana	10-14
12235131-4	2002	Calreticulin is a soluble protein that recognizes primarily the terminal glucose of Glc(1)Man(7-9)GlcNAc(2) glycans.	Polysaccharides	108-115	calreticulin	Homo sapiens	0-12
12487819-4	2002	The objectives of this study were to determine the types of glycans on gp120 important for MBL binding and to determine if alteration of complex glycans with neuraminidase (NA) could enhance the interaction of MBL with virus.	Polysaccharides	60-67	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	71-76
12244067-4	2002	A strain whose FT85 gene is interrupted by a genetic insertion produces a truncated, GlcNAc-terminated glycan on Skp1, suggesting that FT85 may also have beta-galactosyltransferase activity.	Polysaccharides	103-109	S-phase kinase associated protein 1	Homo sapiens	113-117
12244067-9	2002	In conclusion, FT85 is a bifunctional diglycosyltransferase that appears to be designed to efficiently extend the Skp1 glycan in vivo.	Polysaccharides	119-125	S-phase kinase associated protein 1	Homo sapiens	114-118
12433487-7	2002	The difference between the activities of these two polysaccharides is not very pronounced when factor Xa replaces thrombin.	Polysaccharides	51-66	coagulation factor X	Homo sapiens	95-104
12433487-7	2002	The difference between the activities of these two polysaccharides is not very pronounced when factor Xa replaces thrombin.	Polysaccharides	51-66	coagulation factor II, thrombin	Homo sapiens	114-122
12487819-4	2002	The objectives of this study were to determine the types of glycans on gp120 important for MBL binding and to determine if alteration of complex glycans with neuraminidase (NA) could enhance the interaction of MBL with virus.	Polysaccharides	145-152	neuraminidase 1	Homo sapiens	158-171
12487819-4	2002	The objectives of this study were to determine the types of glycans on gp120 important for MBL binding and to determine if alteration of complex glycans with neuraminidase (NA) could enhance the interaction of MBL with virus.	Polysaccharides	145-152	neuraminidase 1	Homo sapiens	173-175
12487819-4	2002	The objectives of this study were to determine the types of glycans on gp120 important for MBL binding and to determine if alteration of complex glycans with neuraminidase (NA) could enhance the interaction of MBL with virus.	Polysaccharides	145-152	mannose binding lectin 2	Homo sapiens	210-213
12379680-8	2002	These results indicate that the polysaccharide portion covalently bound to lipid A plays the principal role in Salmonella LPS-induced activation of NF-kappaB through human CD14/TLR4/MD-2.	Polysaccharides	32-46	CD14 molecule	Homo sapiens	172-176
12520825-7	2002	Alpha-glucosidase inhibitors delay the digestion and absorption of polysaccharides, thus attenuating postprandial hyperglycaemia.	Polysaccharides	67-82	sucrase-isomaltase	Homo sapiens	0-17
12133001-3	2002	To address this issue, we performed an analysis of the carbohydrate-recognition domain (CRD-I) near the N-terminus of recombinant rat galectin-4 (G4-N) by the biotin/avidin-mediated microtitre plate lectin-binding assay with natural glycoproteins (gps)/polysaccharide and by the inhibition of galectin-glycan interactions with a panel of glycosubstances.	Polysaccharides	253-267	galectin 4	Rattus norvegicus	134-144
12133001-3	2002	To address this issue, we performed an analysis of the carbohydrate-recognition domain (CRD-I) near the N-terminus of recombinant rat galectin-4 (G4-N) by the biotin/avidin-mediated microtitre plate lectin-binding assay with natural glycoproteins (gps)/polysaccharide and by the inhibition of galectin-glycan interactions with a panel of glycosubstances.	Polysaccharides	302-308	galectin 4	Rattus norvegicus	134-144
12379680-8	2002	These results indicate that the polysaccharide portion covalently bound to lipid A plays the principal role in Salmonella LPS-induced activation of NF-kappaB through human CD14/TLR4/MD-2.	Polysaccharides	32-46	toll like receptor 4	Homo sapiens	177-181
12370287-2	2002	In mammalian cells, calnexin functions as a chaperone molecule and plays a key role in glycoprotein folding and quality control within the ER by interacting with folding intermediates via their monoglucosylated glycans.	Polysaccharides	211-218	calnexin	Homo sapiens	20-28
12652802-4	2002	On the other hand, gland mucous cell-type mucin secreted from the normal gastric mucosa characteristically contains GlcNAc alpha 1--&gt;4Gal beta--&gt;R structure, and the alpha 4GnT is critical for the biosynthesis of this unique glycan.	Polysaccharides	231-237	LOC100508689	Homo sapiens	42-47
12784674-8	2002	Since alpha-dystroglycan contains 14-15 o-glycans, ser/thr-mannose 2-1 GlcNAc 4-1 Gal 3-2 Sial in the middle third mucin-domain and the sial-o-glycan is essential for laminin-binding, and since alpha-dystroglycan is defective in Fukuyama type sarcolemma with anti both sugar moiety- and peptide-antidodies, defective fukutin causes incomplete o-glycosylation of alpha-dystroglycan.	Polysaccharides	41-48	dystroglycan 1	Homo sapiens	12-24
12635847-7	2002	The hypothesis explains why different metabolic pathways (protein and DNA syntheses, polysaccharide synthesis, and lipid synthesis) use different trinucleotides (GTP, UTP, and CTP, respectively) as an energy source.	Polysaccharides	85-99	solute carrier family 25 member 1	Homo sapiens	176-179
12297228-2	2002	In an ex vivo system based on porcine colonic tissue various neutral and acidic polysaccharides were tested concerning their bioadhesive potential in order to form artificial mucin layers on colon epithelial membranes.	Polysaccharides	80-95	LOC100508689	Homo sapiens	175-180
12244069-4	2002	The difference between the activities of these two polysaccharides is not very pronounced when factor Xa replaced thrombin.	Polysaccharides	51-66	coagulation factor II, thrombin	Homo sapiens	114-122
12244213-1	2002	C-reactive protein (CRP) is an acute-phase protein that binds specifically to phosphorylcholine (PC) as a component of microbial capsular polysaccharide and participates in the innate immune response against microorganisms.	Polysaccharides	138-152	C-reactive protein	Homo sapiens	0-18
12239306-0	2002	Addition of a single gp120 glycan confers increased binding to dendritic cell-specific ICAM-3-grabbing nonintegrin and neutralization escape to human immunodeficiency virus type 1.	Polysaccharides	27-33	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	21-26
12239306-3	2002	The presence of an additional glycan at the N-terminal base of the V2 loop of SHIV(SF162P3) gp120 compared to that of the parental virus was shown to be responsible for the increase in binding to DC-SIGN.	Polysaccharides	30-36	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	92-97
12239306-3	2002	The presence of an additional glycan at the N-terminal base of the V2 loop of SHIV(SF162P3) gp120 compared to that of the parental virus was shown to be responsible for the increase in binding to DC-SIGN.	Polysaccharides	30-36	CD209 molecule	Homo sapiens	196-203
12487325-2	2002	When TJ-48 was fractionated, the dialyzable fraction (F-3) and the polysaccharide fraction (F-5) expressed the in vitro activity.	Polysaccharides	67-81	coagulation factor V	Mus musculus	92-95
12487325-4	2002	When the galacturonan moiety of pectic polysaccharides in F-5 was degraded enzymatically by endo-polygalacturonase, the digestion products significantly increased the activity of F-5.	Polysaccharides	39-54	coagulation factor V	Mus musculus	58-61
12487325-4	2002	When the galacturonan moiety of pectic polysaccharides in F-5 was degraded enzymatically by endo-polygalacturonase, the digestion products significantly increased the activity of F-5.	Polysaccharides	39-54	coagulation factor V	Mus musculus	179-182
12487325-5	2002	Purification the polygalacturonase-digested F-5 indicated that the active substances were composed mainly of the enzyme-resistant or undigestable polysaccharide molecules.	Polysaccharides	146-160	coagulation factor V	Mus musculus	44-47
12487325-6	2002	Gel filtrations and anion-exchange chromatographies of F-5 gave 12 kinds of polysaccharides, and among them, 7 polysaccharides had significant intestinal immune system modulating activity.	Polysaccharides	76-91	coagulation factor V	Mus musculus	55-58
12487325-6	2002	Gel filtrations and anion-exchange chromatographies of F-5 gave 12 kinds of polysaccharides, and among them, 7 polysaccharides had significant intestinal immune system modulating activity.	Polysaccharides	111-126	coagulation factor V	Mus musculus	55-58
12244213-1	2002	C-reactive protein (CRP) is an acute-phase protein that binds specifically to phosphorylcholine (PC) as a component of microbial capsular polysaccharide and participates in the innate immune response against microorganisms.	Polysaccharides	138-152	C-reactive protein	Homo sapiens	20-23
12124847-0	2002	In vitro protein-polysaccharide conjugation: tyrosinase-catalyzed conjugation of gelatin and chitosan.	Polysaccharides	17-31	tyrosinase	Homo sapiens	45-55
12385925-1	2002	OBJECTIVES: To determine whether supplemental amounts of a polysaccharide/oligosaccharide complex obtained from a shiitake mushroom extract (SME) would lower the prostate-specific antigen (PSA) level in patients with prostate cancer.	Polysaccharides	59-73	kallikrein related peptidase 3	Homo sapiens	189-192
12220837-2	2002	The polysaccharide gels were physicochemically characterized and their interaction with enzymes (lysozyme) was studied with the aim to appreciate the performances for separation/purification/immobilization of the enzymes or controlled release drug systems.	Polysaccharides	4-18	lysozyme	Homo sapiens	97-105
12124847-9	2002	These results demonstrate that tyrosinase can be exploited for the in vitro formation of protein-polysaccharide conjugates that offer interesting mechanical properties.	Polysaccharides	97-111	tyrosinase	Homo sapiens	31-41
14501211-2	2002	The relevant glycans are constitutive and developmentally regulated modifications of leechCAM and Tractin (family members of NCAM and L1) that are specific to the surface of sensory afferents.	Polysaccharides	13-20	neural cell adhesion molecule 1	Homo sapiens	125-129
12412198-12	2002	CONCLUSION: Both hydrocortisone and the two polysulphated polysaccharides could stimulate the accumulation of CAM macromolecules of IL-1 beta-treated chondrocytes.	Polysaccharides	58-73	interleukin 1 beta	Homo sapiens	132-141
12200473-1	2002	On the basis of the analysis of 64 glycosyltransferases from 14 species we propose that several successive duplications of a common ancestral gene, followed by divergent evolution, have generated the mannosyltransferases and the glucosyltransferases involved in asparagine-linked glycosylation (ALG) and phosphatidyl-inositol glycan anchor (PIG or GPI), which use lipid-related donor and acceptor substrates.	Polysaccharides	326-332	glucose-6-phosphate isomerase	Sus scrofa	348-351
12034712-6	2002	These glycans are both known to activate FGF signaling via these receptors.	Polysaccharides	6-13	fibroblast growth factor 2	Homo sapiens	41-44
12165299-4	2002	The peroxidase-catalyzed degradation of cell-wall polysaccharides can be inhibited by KCN and superoxide radical (O(2)*) or OH* scavengers.	Polysaccharides	50-65	peroxidase	Glycine max	4-14
12189518-6	2002	Analysis of the germ-free mice intestinal glycosylation baseline revealed that the expression of glycans depends on the proximodistal gradient (small to large intestine) and on the cell lineage (absorptive, goblet, crypt, and Paneth cells), indicating that mice are able to create and maintain a strict topological and cell lineage-specific regulation of glycosyltransferase expression.	Polysaccharides	97-104	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	355-374
12136128-0	2002	Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia.	Polysaccharides	8-14	insulin	Homo sapiens	43-50
12163379-3	2002	Immunohistochemical stainings with monoclonal antibodies against functionally active glycan-decorated L-selectin ligands, ie, sialyl-Lewis x (sLex, 2F3, and HECA-452) or sulfated extended core 1 lactosamine (MECA-79), were performed on more than 400 specimen representatives for thyroiditis, myocarditis, psoriasis, vasculitis, ulcerative colitis, and their corresponding noninflamed tissues.	Polysaccharides	85-91	selectin L	Homo sapiens	102-112
12163379-7	2002	Our results suggest that these zip code glycans may provide means for organ selective leukocyte traffic that could be used in selective leukocyte traffic inhibition.	Polysaccharides	40-47	death associated protein kinase 3	Homo sapiens	31-34
12113804-1	2002	TETRAOSYL HEXAPEPTIDE, A PART OF THE SEQUENCE OF BETAGLYCAN: beta-D-GlcA-(1--&gt;3)-beta-D-Gal-(1--&gt;3)-beta-D-Gal-(1--&gt;4)-beta-D-Xyl-(1--&gt;O-SerGlyTrpProAspGly (1), which was designed as a probe for glycan elongation toward heparin, was synthesized in a stereocontrolled manner.	Polysaccharides	207-213	transforming growth factor beta receptor 3	Homo sapiens	37-59
12147463-7	2002	Comparison of the enzyme activity patterns in A. thermoaerophilus strains DSM 10155 and L420-91(T) for L-rhamnose and D-rhamnose biosynthesis indicated that the enzymes are differentially expressed during S-layer glycan biosynthesis and that A. thermoaerophilus L420-91(T) is not able to synthesize dTDP-L-rhamnose.	Polysaccharides	213-219	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	299-303
12153565-0	2002	Biglycan isoforms with differences in polysaccharide substitution and core protein in human lung fibroblasts.	Polysaccharides	38-52	biglycan	Homo sapiens	0-8
12065474-1	2002	Cryptococcus neoformans and cryptococcal surface polysaccharides influenced C5aR expression on human polymorphonuclear neutrophils (PMN).	Polysaccharides	49-64	complement C5a receptor 1	Homo sapiens	76-80
12133962-2	2002	The murine Mab 18B7 (IgG1) binds to the Cryptococcus neoformans capsular polysaccharide glucuronoxylomannan and produces annular immunofluorescence (IF) on yeast cells.	Polysaccharides	73-87	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	21-25
12212792-5	2002	The offending BM component is a heparan sulfate (HS) proteoglycan (HSPG), part of which is protein and the remainder a specific linear polysaccharide, which is the portion responsible for binding, and imparting the typical amyloid structure, to the amyloid precursor protein/peptide.	Polysaccharides	135-149	amyloid beta precursor protein	Homo sapiens	249-274
12212792-7	2002	The present work is concerned with the design and synthesis of modified sugar precursors of HS, which, when incorporated into the polysaccharide, will alter its structure so that it loses its amyloid precursor protein/peptide-binding and fibril-inducing properties.	Polysaccharides	130-144	amyloid beta precursor protein	Homo sapiens	192-217
12081364-1	2002	Beta-1,3-glucan polymers are major structural components of fungal cell walls, while cellulosic beta-1,4-glucan is the predominant polysaccharide in plant cell walls.	Polysaccharides	131-145	beta-1,2-xylosyltransferase	Arabidopsis thaliana	96-104
12032138-1	2002	The HNK-1 carbohydrate epitope, a sulfated glucuronic acid at the non-reducing terminus of glycans, is expressed characteristically on a series of cell adhesion molecules and is synthesized through a key enzyme, glucuronyltransferase (GlcAT-P).	Polysaccharides	91-98	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	4-9
12032138-1	2002	The HNK-1 carbohydrate epitope, a sulfated glucuronic acid at the non-reducing terminus of glycans, is expressed characteristically on a series of cell adhesion molecules and is synthesized through a key enzyme, glucuronyltransferase (GlcAT-P).	Polysaccharides	91-98	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	235-242
12100021-4	2002	Sulphated glycolipids and sulphated polysaccharides interfere with the binding of P- and L-selectin with carbohydrate ligands on endothelial cells or on leucocytes.	Polysaccharides	36-51	selectin L	Rattus norvegicus	89-99
12234359-5	2002	Recent advances in glycan structure analysis and in characterizing mice with targeted deletions of glycosyltransferase and sulfotransferase genes discloses an essential role for 6-O GlcNAc sulfate modification of the sialyl Lewis x tetrasaccharide in L-selectin counter-receptor activity.	Polysaccharides	19-25	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	99-118
12190874-7	2002	The analysis of glycosylation-deficient mutants revealed regions in tyrosinase with high, low, and intermediate dependency on glycans for maturation.	Polysaccharides	126-133	tyrosinase	Homo sapiens	68-78
12567775-0	2002	[Effect of polysaccharide from Spirulina platensis on hematopoietic cells proliferation, apoptosis and Bcl-2 expression in mice bearing tumor treated with chemotherapy].	Polysaccharides	11-25	B cell leukemia/lymphoma 2	Mus musculus	103-108
12567775-1	2002	AIM: To evaluate the effect of polysaccharide from Spirulina platensis (PSP) on hematopoietic cell proliferation, apoptosis and Bcl-2 expression in mice bearing tumor treated with chemotherapy.	Polysaccharides	31-45	phosphoserine phosphatase	Mus musculus	72-75
12099680-0	2002	Ceruloplasmin carries the anionic glycan oligo/poly alpha2,8 deaminoneuraminic acid.	Polysaccharides	34-40	ceruloplasmin	Rattus norvegicus	0-13
12099680-5	2002	However, the copper binding activity of ceruloplasmin was independent of the presence of the anionic glycan.	Polysaccharides	101-107	ceruloplasmin	Rattus norvegicus	40-53
12199626-5	2002	In skin explant cultures, we could demonstrate that fucose and fucose-rich polysaccharides produced an inhibition of the activation of the pro-form to the active form of MMP-9.	Polysaccharides	75-90	matrix metallopeptidase 9	Homo sapiens	170-175
12199626-7	2002	Fucose and fucose-rich polysaccharide preparations were shown to be efficient modulators of MMP-2 and MMP-9, activity with potential therapeutic applications in age-related pathologies accompanied by tissue loss.	Polysaccharides	23-37	matrix metallopeptidase 2	Homo sapiens	92-97
12199626-7	2002	Fucose and fucose-rich polysaccharide preparations were shown to be efficient modulators of MMP-2 and MMP-9, activity with potential therapeutic applications in age-related pathologies accompanied by tissue loss.	Polysaccharides	23-37	matrix metallopeptidase 9	Homo sapiens	102-107
14707484-5	2002	Many of the glycans detected on the MUC1 mucin were common to both cell types, as would be predicted from biosynthetic constraints.	Polysaccharides	12-19	mucin 1, cell surface associated	Homo sapiens	36-40
14707484-5	2002	Many of the glycans detected on the MUC1 mucin were common to both cell types, as would be predicted from biosynthetic constraints.	Polysaccharides	12-19	LOC100508689	Homo sapiens	41-46
12222658-5	2002	Significant TNF-stimulating activity was found in the extractable polysaccharide fraction, which was hydrolyzed and found to contain glucose, galactose, arabinose, rhamnose, and mannose.	Polysaccharides	66-80	tumor necrosis factor	Rattus norvegicus	12-15
12101282-0	2002	Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathway.	Polysaccharides	0-14	AKT serine/threonine kinase 1	Homo sapiens	172-175
12135555-1	2002	The CMP-sialic acid synthetase (CMP-Neu5Ac, synthetase) is responsible for the synthesis of CMP-Neu5Ac, which is the donor used by sialyltransferases to attach sialic acid to acceptor hydroxyl groups in various polysaccharides, glycolipids, and glycoproteins.	Polysaccharides	211-226	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	4-30
12135555-1	2002	The CMP-sialic acid synthetase (CMP-Neu5Ac, synthetase) is responsible for the synthesis of CMP-Neu5Ac, which is the donor used by sialyltransferases to attach sialic acid to acceptor hydroxyl groups in various polysaccharides, glycolipids, and glycoproteins.	Polysaccharides	211-226	cytidine monophosphate N-acetylneuraminic acid synthetase	Homo sapiens	32-54
11929872-4	2002	Analysis of sequences of various peptide O-xylosyltransferase and beta1,6-N-acetylglucosaminyltransferase sequences indicates that they are members of a large multifunctional protein family with a range of roles in beta-glycosylation of either peptide or glycan substrates.	Polysaccharides	255-261	peptide O-xylosyltransferase	Drosophila melanogaster	33-61
12049826-9	2002	CONCLUSIONS: Otitis prone children, while having normal IgG1 antibody levels, have low IgG2 and IgA anti-polysaccharide antibody levels and fail to respond in these subclasses upon vaccination with pneumococcal polysaccharide vaccine.	Polysaccharides	105-119	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	96-99
12011998-0	2002	PSK, a protein-bound polysaccharide, overcomes defective maturation of dendritic cells exposed to tumor-derived factors in vitro.	Polysaccharides	21-35	TAO kinase 2	Homo sapiens	0-3
12023892-5	2002	The dissociation constant of the hCG complex, with or without the glycan at alphaAsn-52, is less than 1 x 10(-5) s(-1), indicating that the glycan at alphaAsn-52 does not contribute significantly to the stability of the dimer.	Polysaccharides	66-72	chorionic gonadotropin subunit beta 5	Homo sapiens	33-36
12023892-5	2002	The dissociation constant of the hCG complex, with or without the glycan at alphaAsn-52, is less than 1 x 10(-5) s(-1), indicating that the glycan at alphaAsn-52 does not contribute significantly to the stability of the dimer.	Polysaccharides	140-146	chorionic gonadotropin subunit beta 5	Homo sapiens	33-36
12010808-0	2002	The monoclonal antibody CHO-131 binds to a core 2 O-glycan terminated with sialyl-Lewis x, which is a functional glycan ligand for P-selectin.	Polysaccharides	52-58	selectin P	Homo sapiens	131-141
12010808-10	2002	Unlike anti-sLe(X) mAbs, CHO-131 binding also indicates C2GnT activity and demonstrates that CLA T cells are heterogeneous based on the glycan structures they synthesize.	Polysaccharides	136-142	selectin P ligand	Homo sapiens	93-96
11891229-0	2002	Biosynthesis of HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM): the requirement for core 2 beta 1,6-N-acetylglucosaminyltransferase and the muscle-specific domain in NCAM.	Polysaccharides	22-29	beta-1,3-glucuronyltransferase 1	Homo sapiens	16-21
11891229-8	2002	By contrast, HNK-1 glycan was much more efficiently added to N-glycans than O-glycans when NCAM was used as an acceptor.	Polysaccharides	19-25	beta-1,3-glucuronyltransferase 1	Homo sapiens	13-18
11891229-8	2002	By contrast, HNK-1 glycan was much more efficiently added to N-glycans than O-glycans when NCAM was used as an acceptor.	Polysaccharides	19-25	neural cell adhesion molecule 1	Homo sapiens	91-95
12094292-1	2002	Sodium spirulan (Na-SP) is a sulfated polysaccharide isolated from the blue-green alga Spirulina platensis, which consists of two types of disaccharide repeating units, O-hexuronosyl-rhamnose (aldobiuronic acid) and O-rhamnosyl-3-O-methylrhamnose (acofriose) with sulfate groups, other minor saccharides and sodium ion.	Polysaccharides	38-52	nuclear autoantigenic sperm protein	Bos taurus	17-22
12094292-7	2002	The present data suggest that Na-SP is a unique sulfated polysaccharide that strongly inhibits vascular endothelial cell proliferation, and the inhibitory activity requires polymerization of sulfated O-rhamnosyl-acofriose repeating units.	Polysaccharides	57-71	nuclear autoantigenic sperm protein	Bos taurus	30-35
11891229-0	2002	Biosynthesis of HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM): the requirement for core 2 beta 1,6-N-acetylglucosaminyltransferase and the muscle-specific domain in NCAM.	Polysaccharides	22-29	neural cell adhesion molecule 1	Homo sapiens	75-104
11891229-9	2002	These results are consistent with our results showing that HNK-1 glycan is minimally attached to O-glycans of NCAM in fetal brain, heart, and the myoblast cell line, C2C12.	Polysaccharides	65-71	beta-1,3-glucuronyltransferase 1	Homo sapiens	59-64
11891229-9	2002	These results are consistent with our results showing that HNK-1 glycan is minimally attached to O-glycans of NCAM in fetal brain, heart, and the myoblast cell line, C2C12.	Polysaccharides	65-71	neural cell adhesion molecule 1	Homo sapiens	110-114
11891229-0	2002	Biosynthesis of HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM): the requirement for core 2 beta 1,6-N-acetylglucosaminyltransferase and the muscle-specific domain in NCAM.	Polysaccharides	22-29	neural cell adhesion molecule 1	Homo sapiens	106-110
11891229-10	2002	These results combined together indicate that HNK-1 glycan can be synthesized on core 2 branched O-glycans but that the HNK-1 glycan is preferentially added on N-glycans over O-glycans of NCAM, probably because N-glycans are extended further than O-glycans attached to NCAM containing the muscle-specific domain.	Polysaccharides	52-58	beta-1,3-glucuronyltransferase 1	Homo sapiens	46-51
11891229-10	2002	These results combined together indicate that HNK-1 glycan can be synthesized on core 2 branched O-glycans but that the HNK-1 glycan is preferentially added on N-glycans over O-glycans of NCAM, probably because N-glycans are extended further than O-glycans attached to NCAM containing the muscle-specific domain.	Polysaccharides	99-105	beta-1,3-glucuronyltransferase 1	Homo sapiens	46-51
11891229-0	2002	Biosynthesis of HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM): the requirement for core 2 beta 1,6-N-acetylglucosaminyltransferase and the muscle-specific domain in NCAM.	Polysaccharides	22-29	neural cell adhesion molecule 1	Homo sapiens	215-219
11891229-1	2002	The HNK-1 glycan, sulfo--&gt;3GlcAbeta1--&gt;3Galbeta1--&gt;4GlcNAcbeta1--&gt;R, is highly expressed in neuronal cells and apparently plays critical roles in neuronal cell migration and axonal extension.	Polysaccharides	10-16	beta-1,3-glucuronyltransferase 1	Homo sapiens	4-9
11891229-2	2002	The HNK-1 glycan synthesis is initiated by the addition of beta1,3-linked GlcA to N-acetyllactosamine followed by sulfation of the C-3 position of GlcA.	Polysaccharides	10-16	beta-1,3-glucuronyltransferase 1	Homo sapiens	4-9
11891229-2	2002	The HNK-1 glycan synthesis is initiated by the addition of beta1,3-linked GlcA to N-acetyllactosamine followed by sulfation of the C-3 position of GlcA.	Polysaccharides	10-16	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	59-66
11891229-4	2002	Among various adhesion molecules, the neural cell adhesion molecule (NCAM) was shown to contain HNK-1 glycan on N-glycans.	Polysaccharides	102-108	neural cell adhesion molecule 1	Homo sapiens	38-67
11891229-4	2002	Among various adhesion molecules, the neural cell adhesion molecule (NCAM) was shown to contain HNK-1 glycan on N-glycans.	Polysaccharides	102-108	neural cell adhesion molecule 1	Homo sapiens	69-73
11891229-4	2002	Among various adhesion molecules, the neural cell adhesion molecule (NCAM) was shown to contain HNK-1 glycan on N-glycans.	Polysaccharides	102-108	beta-1,3-glucuronyltransferase 1	Homo sapiens	96-101
11891229-5	2002	In the present study, we first demonstrated that NCAM also bears HNK-1 glycan attached to O-glycans when NCAM contains the O-glycan attachment scaffold, muscle-specific domain, and is synthesized in the presence of core 2 beta1,6-N-acetylglucosaminyltransferase, GlcAT-P, and HNK-1ST.	Polysaccharides	71-77	neural cell adhesion molecule 1	Homo sapiens	49-53
11891229-5	2002	In the present study, we first demonstrated that NCAM also bears HNK-1 glycan attached to O-glycans when NCAM contains the O-glycan attachment scaffold, muscle-specific domain, and is synthesized in the presence of core 2 beta1,6-N-acetylglucosaminyltransferase, GlcAT-P, and HNK-1ST.	Polysaccharides	71-77	beta-1,3-glucuronyltransferase 1	Homo sapiens	65-70
11891229-5	2002	In the present study, we first demonstrated that NCAM also bears HNK-1 glycan attached to O-glycans when NCAM contains the O-glycan attachment scaffold, muscle-specific domain, and is synthesized in the presence of core 2 beta1,6-N-acetylglucosaminyltransferase, GlcAT-P, and HNK-1ST.	Polysaccharides	71-77	neural cell adhesion molecule 1	Homo sapiens	105-109
11891229-5	2002	In the present study, we first demonstrated that NCAM also bears HNK-1 glycan attached to O-glycans when NCAM contains the O-glycan attachment scaffold, muscle-specific domain, and is synthesized in the presence of core 2 beta1,6-N-acetylglucosaminyltransferase, GlcAT-P, and HNK-1ST.	Polysaccharides	71-77	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	215-261
11891229-5	2002	In the present study, we first demonstrated that NCAM also bears HNK-1 glycan attached to O-glycans when NCAM contains the O-glycan attachment scaffold, muscle-specific domain, and is synthesized in the presence of core 2 beta1,6-N-acetylglucosaminyltransferase, GlcAT-P, and HNK-1ST.	Polysaccharides	71-77	beta-1,3-glucuronyltransferase 1	Homo sapiens	263-270
11891229-5	2002	In the present study, we first demonstrated that NCAM also bears HNK-1 glycan attached to O-glycans when NCAM contains the O-glycan attachment scaffold, muscle-specific domain, and is synthesized in the presence of core 2 beta1,6-N-acetylglucosaminyltransferase, GlcAT-P, and HNK-1ST.	Polysaccharides	71-77	carbohydrate sulfotransferase 10	Homo sapiens	276-283
11891229-6	2002	Structural analysis of the HNK-1 glycan revealed that the HNK-1 glycan is attached on core 2 branched O-glycans, sulfo--&gt;3GlcAbeta1--&gt;3Galbeta1--&gt;4GlcNAcbeta1--&gt;6(Galbeta1--&gt;3)GalNAc.	Polysaccharides	33-39	beta-1,3-glucuronyltransferase 1	Homo sapiens	27-32
11891229-6	2002	Structural analysis of the HNK-1 glycan revealed that the HNK-1 glycan is attached on core 2 branched O-glycans, sulfo--&gt;3GlcAbeta1--&gt;3Galbeta1--&gt;4GlcNAcbeta1--&gt;6(Galbeta1--&gt;3)GalNAc.	Polysaccharides	33-39	beta-1,3-glucuronyltransferase 1	Homo sapiens	58-63
11891229-6	2002	Structural analysis of the HNK-1 glycan revealed that the HNK-1 glycan is attached on core 2 branched O-glycans, sulfo--&gt;3GlcAbeta1--&gt;3Galbeta1--&gt;4GlcNAcbeta1--&gt;6(Galbeta1--&gt;3)GalNAc.	Polysaccharides	64-70	beta-1,3-glucuronyltransferase 1	Homo sapiens	27-32
11891229-6	2002	Structural analysis of the HNK-1 glycan revealed that the HNK-1 glycan is attached on core 2 branched O-glycans, sulfo--&gt;3GlcAbeta1--&gt;3Galbeta1--&gt;4GlcNAcbeta1--&gt;6(Galbeta1--&gt;3)GalNAc.	Polysaccharides	64-70	beta-1,3-glucuronyltransferase 1	Homo sapiens	58-63
11872745-1	2002	VIP36, an intracellular lectin that recognizes high mannose-type glycans (Hara-Kuge, S., Ohkura, T., Seko, A., and Yamashita, K. (1999) Glycobiology 9, 833-839), was shown to localize not only to the early secretory pathway but also to the plasma membrane of Madin-Darby canine kidney (MDCK) cells.	Polysaccharides	65-72	lectin, mannose binding 2	Canis lupus familiaris	0-5
12007475-3	2002	1H NMR studies of these modified polysaccharides show that the neighboring sulfate groups at the C-2 and C-3 positions might have caused the conformational changes of each monosaccharide from 4C(1) to 1C(4).	Polysaccharides	33-48	complement C2	Homo sapiens	97-100
11986228-7	2002	We report here that HLA-A2402(+) DCs could incorporate hydrophobized polysaccharide-truncated HER2 protein complexes and process the protein to present major histocompatibility complex class 1-binding HER2p63 peptide.	Polysaccharides	69-83	erb-b2 receptor tyrosine kinase 2	Mus musculus	94-98
11872745-8	2002	Furthermore, the overproduction of VIP36 greatly stimulated the secretion of a major apical secretory glycoprotein of MDCK cells, clusterin, which was found to carry at least one high mannose-type glycan and to be recognized by VIP36.	Polysaccharides	197-203	lectin, mannose binding 2	Canis lupus familiaris	35-40
11872745-10	2002	These results indicated that VIP36 was involved in the transport and sorting of glycoproteins carrying high mannose-type glycan(s).	Polysaccharides	121-127	lectin, mannose binding 2	Canis lupus familiaris	29-34
11984787-9	2002	Upregulation of calnexin was also observed in cells transfected with the complement protein factor B, a glycoprotein with extensive structural and functional similarities to C2, but not in cells transfected with complement proteins C3 or factor D, which have no structural similarity to C2, and low or no glycan content, respectively.	Polysaccharides	305-311	calnexin	Homo sapiens	16-24
11984787-11	2002	Increased calnexin expression by overexpressed C2 and factor B appears to be triggered either by the high glycan content of these proteins or, since it also occurs in the presence of castanospermine, by shared features of the structure of these two proteins.	Polysaccharides	106-112	calnexin	Homo sapiens	10-18
11984787-11	2002	Increased calnexin expression by overexpressed C2 and factor B appears to be triggered either by the high glycan content of these proteins or, since it also occurs in the presence of castanospermine, by shared features of the structure of these two proteins.	Polysaccharides	106-112	complement C2	Homo sapiens	47-62
11964163-0	2002	Overloading and removal of N-glycosylation targets on human acetylcholinesterase: effects on glycan composition and circulatory residence time.	Polysaccharides	93-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	60-80
12168863-2	2002	PSK and Polysaccharopeptide (PSP) are both protein-bound polysaccharides which are derived from the CM-101 and COV-1 strains of the fungus Coriolus versicolor by Japanese and Chinese researchers, respectively.	Polysaccharides	57-72	TAO kinase 2	Homo sapiens	0-3
12168863-18	2002	Much of the research that has been done on PSK is outlined in this paper and may serve as a foundation toward determining the mechanisms of action of this and other protein-bound polysaccharides in the treatment of cancer.	Polysaccharides	179-194	TAO kinase 2	Homo sapiens	43-46
12168863-1	2002	Polysaccharide-K (polysaccharide-Kureha; PSK), also known as krestin, is a unique protein-bound polysaccharide, which has been used as a chemoimmunotherapy agent in the treatment of cancer in Asia for over 30 years.	Polysaccharides	18-32	TAO kinase 2	Homo sapiens	0-16
12168863-1	2002	Polysaccharide-K (polysaccharide-Kureha; PSK), also known as krestin, is a unique protein-bound polysaccharide, which has been used as a chemoimmunotherapy agent in the treatment of cancer in Asia for over 30 years.	Polysaccharides	18-32	TAO kinase 2	Homo sapiens	41-44
12168863-1	2002	Polysaccharide-K (polysaccharide-Kureha; PSK), also known as krestin, is a unique protein-bound polysaccharide, which has been used as a chemoimmunotherapy agent in the treatment of cancer in Asia for over 30 years.	Polysaccharides	96-110	TAO kinase 2	Homo sapiens	0-16
12168863-1	2002	Polysaccharide-K (polysaccharide-Kureha; PSK), also known as krestin, is a unique protein-bound polysaccharide, which has been used as a chemoimmunotherapy agent in the treatment of cancer in Asia for over 30 years.	Polysaccharides	96-110	TAO kinase 2	Homo sapiens	41-44
11964163-11	2002	This study provides evidence that glycan loading, together with N-glycan terminal processing and enzyme subunit oligomerization, operate in a hierarchical and concerted manner in determining the pharmacokinetic characteristics of AChE.	Polysaccharides	34-40	acetylcholinesterase (Cartwright blood group)	Homo sapiens	230-234
11932385-3	2002	Strong evidence for such a role for glycosylation has been reported for simian immunodeficiency virus (SIV) mutants lacking glycans in the V1 region of Env (J. N. Reitter, R. E. Means, and R. C. Desrosiers, Nat.	Polysaccharides	124-131	envelope protein	Simian immunodeficiency virus	152-155
12108544-3	2002	Here we show that NDST-2+/+ bone marrow-derived mast cells cultured in the presence of IL-3 synthesise, in addition to highly sulphated chondroitin sulphate (CS), small amounts of equally highly sulphated heparin-like polysaccharide.	Polysaccharides	218-232	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	18-24
12108544-3	2002	Here we show that NDST-2+/+ bone marrow-derived mast cells cultured in the presence of IL-3 synthesise, in addition to highly sulphated chondroitin sulphate (CS), small amounts of equally highly sulphated heparin-like polysaccharide.	Polysaccharides	218-232	interleukin 3	Mus musculus	87-91
11997105-3	2002	Northern blot analysis showed that the gene is preferentially expressed in fiber cells and its transcripts are abundant both at the primary cell wall elongation stage and at the later stage of secondary cell thickening, suggesting that GhRGP1 may be involved in non-cellulosic polysaccharide biosynthesis of the plant cell wall.	Polysaccharides	277-291	alpha-1,4-glucan-protein synthase [UDP-forming] 2-like	Gossypium hirsutum	236-242
11956642-0	2002	Effectiveness of immunochemotherapy with PSK, a protein-bound polysaccharide, in colorectal cancer and changes of tumor marker.	Polysaccharides	62-76	TAO kinase 2	Homo sapiens	41-44
11939772-1	2002	The anticoagulant sulfated polysaccharide, heparin, binds to the plasma coagulation proteinase inhibitor, antithrombin, and activates it by a conformational change that results in a greatly increased rate of inhibition of target proteinases.	Polysaccharides	27-41	serpin family C member 1	Homo sapiens	106-118
12042249-7	2002	The soluble form of CD59, expressed in CHO cells without the GPI anchor signal sequence, consisted almost entirely (97%) of biantennary glycans, of which 81% were unmodified, 17% contained one N-acetyllactosamine extension, and 2% contained two extensions.	Polysaccharides	136-143	CD59 glycoprotein	Cricetulus griseus	20-24
11895802-6	2002	If a given CD34-glycan may carry all requirements for L-selectin recognition, that is, both 6-sulfo-sLex and MECA-79 epitopes, only one O-glycan fraction, O-9, SA(2)Hex(3)HexNAc(3)- Fuc(1)(SO(3))(1), meets the criteria.	Polysaccharides	15-22	selectin L	Homo sapiens	54-64
11895802-8	2002	However, if sulfo sLex glycans are supplemented with separate sulfated, nonfucosylated O-glycans, saccharides in O-6, O-8, or O-9, putatively carrying MECA-79 epitopes, could form multiglycan binding epitopes for L-selectin.	Polysaccharides	23-30	immunoglobulin kappa variable 1D-35 (pseudogene)	Homo sapiens	113-129
11934350-2	2002	Fondaparinux is a synthetic polysaccharide that selectively binds to antithrombin, the primary endogenous regulator of blood coagulation.	Polysaccharides	28-42	serpin family C member 1	Homo sapiens	69-81
12099510-0	2002	In vitro release behavior of insulin from biodegradable hybrid hydrogel networks of polysaccharide and synthetic biodegradable polyester.	Polysaccharides	84-98	insulin	Homo sapiens	29-36
11988021-2	2002	It is likely that carbohydrates play a significant role in regulating agrin activity, as agrin binds multiple glycan structures and is itself a highly glycosylated protein.	Polysaccharides	110-116	agrin	Homo sapiens	70-75
11907102-2	2002	Increased susceptibility to fatal pneumococcal sepsis due to absence of anti-polysaccharide IgG3 is corrected by induction of anti-polysaccharide IgG1.	Polysaccharides	131-145	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	146-150
11907102-3	2002	Bacterial polysaccharides (PS) are type 2 T-independent Ags that elicit Abs restricted in isotype to IgM and predominantly IgG2 in humans and IgM, and IgG3 in mice.	Polysaccharides	10-25	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	151-155
11907102-3	2002	Bacterial polysaccharides (PS) are type 2 T-independent Ags that elicit Abs restricted in isotype to IgM and predominantly IgG2 in humans and IgM, and IgG3 in mice.	Polysaccharides	27-29	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	151-155
11988021-2	2002	It is likely that carbohydrates play a significant role in regulating agrin activity, as agrin binds multiple glycan structures and is itself a highly glycosylated protein.	Polysaccharides	110-116	agrin	Homo sapiens	89-94
12010484-7	2002	Addition of glycans resulted in lower rec15/24-specific IgG1 and IgA in 9-month-old sheep after challenge.	Polysaccharides	12-19	IGA	Ovis aries	65-68
12010484-9	2002	A significant negative correlation was found between IgA and worm numbers in protected sheep immunized with rec15/24 supplemented with glycans.	Polysaccharides	135-142	IGA	Ovis aries	53-56
11943202-5	2002	The addition of high concentrations of different polymers (proteins, polysaccharides and polyethylene glycols) dramatically accelerated alpha-synuclein fibrillation in vitro.	Polysaccharides	69-84	synuclein alpha	Homo sapiens	136-151
11941457-3	2002	Backbone cleavage of cell wall polysaccharides can be accomplished in vitro by (*OH) produced from H2O2 in a Fenton reaction or in a reaction catalyzed by peroxidase supplied with O2 and NADH.	Polysaccharides	31-46	peroxidase 1	Zea mays	155-165
11943153-6	2002	This indicates that glycans are partly involved in CD4 association with CXCR4 and may partly explain the inhibitory effect of SDF-1alpha on HIV infection.	Polysaccharides	20-27	CD4 molecule	Homo sapiens	51-54
11943153-6	2002	This indicates that glycans are partly involved in CD4 association with CXCR4 and may partly explain the inhibitory effect of SDF-1alpha on HIV infection.	Polysaccharides	20-27	C-X-C motif chemokine receptor 4	Homo sapiens	72-77
11854459-5	2002	Because the mur1 mutation affects several cell wall polysaccharides, whereas the mur2 mutation is specific to xyloglucan, the phenotypes of mur1 plants appear to be caused by structural changes in fucosylated pectic components such as rhamnogalacturonan-II.	Polysaccharides	52-67	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	12-16
11953450-4	2002	The binding potential of amphoterin to RAGE decreases significantly in presence of soluble carboxylated glycans or when the receptor is deglycosylated.	Polysaccharides	104-111	high mobility group box 1	Homo sapiens	25-35
11842255-6	2002	In both culture systems, growth of virus lacking this glycan (mutant cg1) was completely blocked at 37 degrees C and inhibited at 33 degrees C. Loss of the glycan from Asn(478) (mutant cg3) caused less striking, but still measurable, effects.	Polysaccharides	54-60	mastermind like domain containing 1	Homo sapiens	69-72
11953450-4	2002	The binding potential of amphoterin to RAGE decreases significantly in presence of soluble carboxylated glycans or when the receptor is deglycosylated.	Polysaccharides	104-111	advanced glycosylation end-product specific receptor	Homo sapiens	39-43
11953450-7	2002	The carboxylated glycans themselves promote neurite outgrowth in embryonic neurons and RAGE-transfected neuroblastoma cells.	Polysaccharides	17-24	advanced glycosylation end-product specific receptor	Homo sapiens	87-91
12064867-8	2002	Finally, we determined the structural class of the glycan of one V1 glycosylation site of prototype HIV-1 LAI gp120, which remained unsolved from previous studies, and found that it belonged to the complex type of glycans.	Polysaccharides	214-221	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	110-115
11933115-3	2002	injections of 2 mg of a polysaccharide fraction isolated from Echinacea purpurea herb cell cultures (EPS-EPO VIIa).	Polysaccharides	24-38	erythropoietin	Homo sapiens	105-108
11804706-2	2002	The amyloid beta is not only associated with P protein and glycans, as was well known from previous immunohistologic studies, but is arranged in the form of short chains at right angles to a P protein backbone with the glycans wrapped around that backbone.	Polysaccharides	59-66	amyloid beta precursor protein	Homo sapiens	4-16
11804706-2	2002	The amyloid beta is not only associated with P protein and glycans, as was well known from previous immunohistologic studies, but is arranged in the form of short chains at right angles to a P protein backbone with the glycans wrapped around that backbone.	Polysaccharides	219-226	amyloid beta precursor protein	Homo sapiens	4-16
12064867-8	2002	Finally, we determined the structural class of the glycan of one V1 glycosylation site of prototype HIV-1 LAI gp120, which remained unsolved from previous studies, and found that it belonged to the complex type of glycans.	Polysaccharides	51-57	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	110-115
11895165-0	2002	Net energy value of two low-digestible carbohydrates, Lycasin HBC and the hydrogenated polysaccharide fraction of Lycasin HBC in healthy human subjects and their impact on nutrient digestive utilization.	Polysaccharides	87-101	keratin 88, pseudogene	Homo sapiens	122-125
11866878-0	2002	Structural characterization and biological activities of SC4, an acidic polysaccharide from Salvia chinensis.	Polysaccharides	72-86	secretory carrier membrane protein 4	Mus musculus	57-60
11866878-1	2002	AIM: To study the chemical characterization and some biological activities of an acidic polysaccharide, named SC4 from Salvia chinensis.	Polysaccharides	88-102	secretory carrier membrane protein 4	Mus musculus	110-113
11866878-4	2002	RESULTS: SC4 was a highly branched polysaccharide with mean molecular weight of 4.5 10(5), composed of Rha, Xyl, Ser, Gal, and GalA in the molar ratio of 1.0 7.0 5.3 1.2 4.2.	Polysaccharides	35-49	secretory carrier membrane protein 4	Mus musculus	9-12
11866878-8	2002	CONCLUSION: SC4, the acidic polysaccharide with complicated structure, was a B-lymphocyte stimulator and protected PC12 cells at the concentration of 20 mg/L against H2O2-induced injury.	Polysaccharides	28-42	secretory carrier membrane protein 4	Mus musculus	12-15
11822911-2	2002	The EPO structure has a high glycan content which is essential for bioactivity but shows considerable molecular heterogeneity.	Polysaccharides	29-35	erythropoietin	Homo sapiens	4-7
12545205-7	2002	The positive reaction of N-cadherin from the WM35 cell line with Galanthus nivalis agglutinin (GNA), Datura stramonium agglutinin (DSA) and Sambucus nigra agglutinin (SNA) indicated the presence of high-mannose type glycans and biantennary complex type oligosaccharides with alpha2-6 linked sialic acid.	Polysaccharides	216-223	cadherin 2	Homo sapiens	25-35
11916311-9	2002	As in AGP and Tf, about 30% the of molecules lacked one glycan unit.	Polysaccharides	56-62	transferrin	Homo sapiens	14-16
11916311-11	2002	In alpha1-AT, 19 and 17% of the molecules lacked two glycans in both samples, respectively.	Polysaccharides	53-60	serpin family A member 1	Homo sapiens	3-12
11756151-5	2002	Instead, SDF-1 increases, uniquely associated with sulfated glycan-mobilizing treatments and not with several other mobilizing agents tested, are likely responsible.	Polysaccharides	60-66	chemokine (C-X-C motif) ligand 12	Mus musculus	9-14
11781369-1	2002	Low molecular weight fragmentation products of the polysaccharide of Hyaluronic acid (sHA) produced during inflammation have been shown to be potent activators of immunocompetent cells such as dendritic cells (DCs) and macrophages.	Polysaccharides	51-65	shaven	Mus musculus	86-89
11781369-9	2002	In conclusion, this is the first report that polysaccharide degradation products of the extracellular matrix produced during inflammation might serve as an endogenous ligand for the TLR-4 complex on DCs.	Polysaccharides	45-59	toll-like receptor 4	Mus musculus	182-187
11822911-9	2002	Enzymatic removal of the glycan moiety of EPO in all cases resulted in a single molecular form with a molecular weight of 18 000, which corresponded to non-glycosylated EPO.	Polysaccharides	25-31	erythropoietin	Homo sapiens	42-45
11822911-9	2002	Enzymatic removal of the glycan moiety of EPO in all cases resulted in a single molecular form with a molecular weight of 18 000, which corresponded to non-glycosylated EPO.	Polysaccharides	25-31	erythropoietin	Homo sapiens	169-172
11825881-4	2002	Though the role of these molecules in synapse formation and function is still poorly understood, there is increasing evidence that the function of agrin, a synaptogenic factor in neuromuscular formation, is modulated by several glycans.	Polysaccharides	228-235	agrin	Mus musculus	147-152
12652078-9	2002	These results are the first to identify differences between pHp and sHp glycosylation and lay groundwork further studies to characterize anomalies in glycan composition and structure, which likely impart pHp with known immunomodulatory functions and may be used as epitopes for development of immune based therapeutics for novel, non-surgical management of endometriosis.	Polysaccharides	150-156	N-acylsphingosine amidohydrolase 1	Homo sapiens	204-207
11848445-8	2002	In summary, the structurally different polysaccharides, heparin, fucoidan (and fucans) have distinguishable effects on mitogenesis and ERK1/ERK2 activation, suggesting that different mechanism(s) mediate these actions.	Polysaccharides	39-54	mitogen-activated protein kinase 3	Homo sapiens	135-139
11808787-13	2002	A polysaccharide fraction secreted by OLL1073R-1 also exhibited the inhibitory effects on both development of CIA and secretion of IFN-gamma.	Polysaccharides	2-16	interferon gamma	Mus musculus	131-140
11848445-8	2002	In summary, the structurally different polysaccharides, heparin, fucoidan (and fucans) have distinguishable effects on mitogenesis and ERK1/ERK2 activation, suggesting that different mechanism(s) mediate these actions.	Polysaccharides	39-54	mitogen-activated protein kinase 1	Homo sapiens	140-144
11739166-7	2001	Charge analysis demonstrated that human serum EPO contained only mono-, di-, and tri-acidic oligosaccharides and lacked the tetra-acidic structures present in the glycans from rhEPO.	Polysaccharides	163-170	erythropoietin	Homo sapiens	46-49
11739166-10	2001	The detection of glycan structural discrepancies between human serum EPO and rhEPO by sugar profiling may be significant for diagnosing pathologic conditions, maintaining pharmaceutical quality control, and establishing a direct method to detect the misuse of rhEPO in sports.	Polysaccharides	17-23	erythropoietin	Homo sapiens	69-72
11794525-1	2001	In order to find potent virus-cell fusion inhibitory components from Korean edible clams, thirteen prepared polysaccharides were introduced to syncytia formation inhibition assay, which is based on the interaction between the HIV-1 envelope protein gp120/41 and the cellular membrane protein CD4 of T lymphocytes.	Polysaccharides	108-123	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	249-257
11749812-1	2001	AIM: To observe polysaccharide of Spirulina platensis (PSp) on the hematopoietic system of mouse and dogs which were damaged by injection of cyclophosphamide (CTX) and 60Co-gamma irradiation.	Polysaccharides	16-30	persephin	Mus musculus	55-58
11749971-3	2001	By making use of electrospray mass spectrometry, the molecular mass of ZmERabp1 was determined to be 20,243 Da comprising a sugar moiety of 1865 Da, corresponding to a high mannose-type glycan structure.	Polysaccharides	186-192	auxin-binding protein 1	Zea mays	71-79
11731113-1	2001	A polysaccharide, a glucan with mean M(r) of 1.0 x 10(6) (MP1), was isolated from the mesocarp of fruits of Orbignya phalerata.	Polysaccharides	2-16	pitrilysin metallopeptidase 1	Homo sapiens	58-61
11737213-0	2001	Core structures of polysialylated glycans present in neural cell adhesion molecule from newborn mouse brain.	Polysaccharides	34-41	neural cell adhesion molecule 1	Mus musculus	53-82
11805078-5	2001	We have introduced a mutation into the mouse germline that recapitulates the glycan biosynthetic defect responsible for human CDG type IIa (CDG-IIa).	Polysaccharides	77-83	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	140-147
11814014-0	2001	Characterization of glycans in a lactoferrin isoform, lactoferrin-a.	Polysaccharides	20-27	lactotransferrin	Bos taurus	33-44
11814014-1	2001	The presence of glycan at Asn-281 in bovine lactoferrin-a, which has a higher molecular weight than regular lactoferrin-b, was found in our previous study.	Polysaccharides	16-22	lactotransferrin	Bos taurus	44-55
11814014-1	2001	The presence of glycan at Asn-281 in bovine lactoferrin-a, which has a higher molecular weight than regular lactoferrin-b, was found in our previous study.	Polysaccharides	16-22	lactotransferrin	Bos taurus	108-119
11814014-0	2001	Characterization of glycans in a lactoferrin isoform, lactoferrin-a.	Polysaccharides	20-27	lactotransferrin	Bos taurus	54-65
11814014-2	2001	The present work was performed to clarify the structures of the glycans linked to the five N-glycosylation sites in lactoferrin-a and to compare them with those of glycans linked to lactoferrin-b.	Polysaccharides	64-71	lactotransferrin	Bos taurus	116-127
11791722-0	2001	Glycoproteins secreted from suspension-cultured tobacco BY2 cells have distinct glycan structures from intracellular glycoproteins.	Polysaccharides	80-86	F-box protein PP2-B11-like	Nicotiana tabacum	56-59
11814014-2	2001	The present work was performed to clarify the structures of the glycans linked to the five N-glycosylation sites in lactoferrin-a and to compare them with those of glycans linked to lactoferrin-b.	Polysaccharides	164-171	lactotransferrin	Bos taurus	182-193
11814014-3	2001	In lactoferrin-a, the glycans linked to Asn-233 and Asn-545 were of the high-mannose type, whereas those present at Asn-368 and Asn-476 were complex-type ones.	Polysaccharides	22-29	lactotransferrin	Bos taurus	3-14
11814014-5	2001	A comparative study of the glycans on bovine lactoferrin-a and bovine lactoferrin-b by HPLC showed that the structures of the glycans linked to Asn-368, Asn-476, and Asn-545 were very similar, the exception being the glycan linked to Asn-233.	Polysaccharides	27-34	lactotransferrin	Bos taurus	45-56
11814014-5	2001	A comparative study of the glycans on bovine lactoferrin-a and bovine lactoferrin-b by HPLC showed that the structures of the glycans linked to Asn-368, Asn-476, and Asn-545 were very similar, the exception being the glycan linked to Asn-233.	Polysaccharides	27-34	lactotransferrin	Bos taurus	70-81
11814014-5	2001	A comparative study of the glycans on bovine lactoferrin-a and bovine lactoferrin-b by HPLC showed that the structures of the glycans linked to Asn-368, Asn-476, and Asn-545 were very similar, the exception being the glycan linked to Asn-233.	Polysaccharides	126-133	lactotransferrin	Bos taurus	45-56
11814014-5	2001	A comparative study of the glycans on bovine lactoferrin-a and bovine lactoferrin-b by HPLC showed that the structures of the glycans linked to Asn-368, Asn-476, and Asn-545 were very similar, the exception being the glycan linked to Asn-233.	Polysaccharides	126-133	lactotransferrin	Bos taurus	70-81
11814014-5	2001	A comparative study of the glycans on bovine lactoferrin-a and bovine lactoferrin-b by HPLC showed that the structures of the glycans linked to Asn-368, Asn-476, and Asn-545 were very similar, the exception being the glycan linked to Asn-233.	Polysaccharides	27-33	lactotransferrin	Bos taurus	45-56
11814014-5	2001	A comparative study of the glycans on bovine lactoferrin-a and bovine lactoferrin-b by HPLC showed that the structures of the glycans linked to Asn-368, Asn-476, and Asn-545 were very similar, the exception being the glycan linked to Asn-233.	Polysaccharides	27-33	lactotransferrin	Bos taurus	70-81
11814014-6	2001	In addition, analysis of the structure of the glycan bound to Asn-281 present only in lactoferrin-a showed it possessed the heterogeneous structure of a complex-type glycan in which the structures Man3GlcNAc2, Man3GlcNAc4, Man3GlcNAc4Fuc are suggested to be present based on HPLC retention times only.	Polysaccharides	46-52	lactotransferrin	Bos taurus	86-97
11814014-6	2001	In addition, analysis of the structure of the glycan bound to Asn-281 present only in lactoferrin-a showed it possessed the heterogeneous structure of a complex-type glycan in which the structures Man3GlcNAc2, Man3GlcNAc4, Man3GlcNAc4Fuc are suggested to be present based on HPLC retention times only.	Polysaccharides	166-172	lactotransferrin	Bos taurus	86-97
11672902-3	2001	The N306 glycan in gp120 shields HIV-1 from neutralizing antibodies.	Polysaccharides	9-15	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	19-24
11763042-6	2001	Polysaccharide extracts of this organism adsorbed high amounts of both Cd2+ (I15-425 microgmg(-1)) and Mn2+ (473-906 microgmg(-1)).	Polysaccharides	0-14	CD2 molecule	Homo sapiens	71-74
11738084-0	2001	The glycan structure of albumin Redhill, a glycosylated variant of human serum albumin.	Polysaccharides	4-10	albumin	Homo sapiens	73-86
11533057-10	2001	Our results suggest a model for tryptase tetramer formation that involves bridging of tryptase monomers by heparin or other highly sulfated polysaccharides of sufficient chain length.	Polysaccharides	140-155	tryptase alpha/beta 1	Mus musculus	32-40
11719190-5	2001	Hence, glycans on the CD8beta stalk appear to modulate the ability of the distal binding surface of the dimeric CD8 globular head domains to clamp MHCI.	Polysaccharides	7-14	CD8b molecule	Homo sapiens	22-29
11719190-5	2001	Hence, glycans on the CD8beta stalk appear to modulate the ability of the distal binding surface of the dimeric CD8 globular head domains to clamp MHCI.	Polysaccharides	7-14	CD8a molecule	Homo sapiens	22-25
11595658-8	2001	These data indicate the requirement for three or more polysaccharide chains for normal CRFR1 function.	Polysaccharides	54-68	corticotropin releasing hormone receptor 1	Homo sapiens	87-92
11791722-1	2001	Glycan structures of glycoproteins secreted in the spent medium of tobacco BY2 suspension-cultured cells were analyzed.	Polysaccharides	0-6	F-box protein PP2-B11-like	Nicotiana tabacum	75-78
11677019-1	2001	The crude hydroalcoholic extract of Mahonia aquifolium stem bark and a polysaccharide isolated from the extract were tested for their activity on interleukin-8 (IL-8) production by human monocytic cell line THP-1.	Polysaccharides	71-85	GLI family zinc finger 2	Homo sapiens	207-212
11757072-5	2001	VIG10, a mouse monoclonal antibody of unknown specificity that expresses HibId-1, and 23F.2, an A2-utilizing Streptococcus pneumoniae 23F polysaccharide-specific human Fab fragment that lacks HibId-1, provide examples of the HibId-1 determinant both arising and being lost by somatic mutation.	Polysaccharides	138-152	FA complementation group B	Homo sapiens	168-171
11598089-1	2001	The capsular polysaccharide of group B Neisseria meningitidis is composed of a linear homopolymer of alpha(2-8) N-acetyl neuraminic acid or polysialic acid (PSA) that is also carried by isoforms of the mammalian neural cell adhesion molecule (NCAM), which is especially expressed on brain cells during development.	Polysaccharides	13-27	neural cell adhesion molecule 1	Homo sapiens	212-241
11598089-1	2001	The capsular polysaccharide of group B Neisseria meningitidis is composed of a linear homopolymer of alpha(2-8) N-acetyl neuraminic acid or polysialic acid (PSA) that is also carried by isoforms of the mammalian neural cell adhesion molecule (NCAM), which is especially expressed on brain cells during development.	Polysaccharides	13-27	neural cell adhesion molecule 1	Homo sapiens	243-247
11588155-4	2001	The distribution and diversity of the apoB100 glycans isolated from all individuals was highly conserved.	Polysaccharides	46-53	apolipoprotein B	Homo sapiens	38-45
11690653-9	2001	In addition, the present study demonstrates that the recombinant hST3Gal I polypeptides transiently expressed in COS-7 cells are glycosylated with complex and high mannose type glycans on each of the five potential N-glycosylation sites.	Polysaccharides	177-184	tumor-suppressor, HELA cell type	Homo sapiens	65-69
11486003-0	2001	Deletion of specific glycan chains affects differentially the stability, local structures, and activity of lecithin-cholesterol acyltransferase.	Polysaccharides	21-27	phosphatidylcholine-sterol acyltransferase	Cricetulus griseus	107-143
11816710-3	2001	It inhibits thrombin due to the formation of a covalent complex with heparin cofactor II, as in the case of mammalian dermatan sulfate, but the effect occurs at lower concentrations for the invertebrate polysaccharide.	Polysaccharides	203-217	coagulation factor II, thrombin	Homo sapiens	12-20
11473122-2	2001	Here, we report the FGF2 antagonist and antiangiogenic activity of novel sulfated derivatives of the Escherichia coli K5 polysaccharide.	Polysaccharides	121-135	fibroblast growth factor 2	Cricetulus griseus	20-24
11720004-3	2001	The galactose-deficient IgA1 in the circulation is recognized by naturally occurring antibodies with anti-glycan specificity, and immune complexes are formed.	Polysaccharides	106-112	immunoglobulin heavy constant alpha 1	Homo sapiens	24-28
11445570-1	2001	The effects of polysaccharide, polyethylene glycol, and protein-crowding agents on the refolding of glucose-6-phosphate dehydrogenase (G6PDH) and protein disulfide isomerase have been examined.	Polysaccharides	15-29	glucose-6-phosphate dehydrogenase	Homo sapiens	135-140
11693527-3	2001	Human CD1c proteins mediate T cell recognition of polyisoprenyl glycolipids, evolutionarily conserved phosphoglycolipids, which function in glycan synthesis pathways.	Polysaccharides	140-146	CD1c molecule	Homo sapiens	6-10
11553589-1	2001	Variable-region-identical mouse immunoglobulin G1 (IgG1), IgG2b, and IgG2a monoclonal antibodies to the capsular polysaccharide of Cryptococcus neoformans prolong the lives of mice infected with this fungus, while IgG3 is either not protective or enhances infection.	Polysaccharides	113-127	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	32-49
11553589-1	2001	Variable-region-identical mouse immunoglobulin G1 (IgG1), IgG2b, and IgG2a monoclonal antibodies to the capsular polysaccharide of Cryptococcus neoformans prolong the lives of mice infected with this fungus, while IgG3 is either not protective or enhances infection.	Polysaccharides	113-127	immunoglobulin heavy variable V1-9	Mus musculus	69-74
11703667-0	2001	Cas1p is a membrane protein necessary for the O-acetylation of the Cryptococcus neoformans capsular polysaccharide.	Polysaccharides	100-114	BCAR1 scaffold protein, Cas family member	Homo sapiens	0-5
11577689-0	2001	Sd(a)-antigen-like structures carried on core 3 are prominent features of glycans from the mucin of normal human descending colon.	Polysaccharides	74-81	LOC100508689	Homo sapiens	91-96
11577689-1	2001	This paper describes structural characterization by NMR, MS and degradative studies of mucin glycans from normal human descending colon obtained freshly at autopsy.	Polysaccharides	93-100	LOC100508689	Homo sapiens	87-92
11532966-8	2001	Since O-GlcNAc plays a critical role in the regulation of signaling pathways of higher plants, the glycan modification is likely to perform similar signaling functions in mammalian cells.	Polysaccharides	99-105	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	6-14
11562071-0	2001	Protective effects of a protein-bound polysaccharide, PSK, on Candida albicans infection in mice via tumor necrosis factor-alpha induction.	Polysaccharides	38-52	TAO kinase 2	Mus musculus	54-57
11562071-0	2001	Protective effects of a protein-bound polysaccharide, PSK, on Candida albicans infection in mice via tumor necrosis factor-alpha induction.	Polysaccharides	38-52	tumor necrosis factor	Mus musculus	101-128
11562071-1	2001	We investigated the protective mechanism of a protein-bound polysaccharide, PSK, against lethal infection with Candida albicans (C. albicans) in mice.	Polysaccharides	60-74	TAO kinase 2	Mus musculus	76-79
11530211-5	2001	Glycans mediate the interaction of newly synthesized glycoproteins with some resident ER folding factors, such as calnexin and calreticulin.	Polysaccharides	0-7	calnexin	Homo sapiens	114-122
11384997-9	2001	When the CRDs are clustered in the tetrameric extracellular domain, their arrangement provides a means of amplifying specificity for multiple glycans on host molecules targeted by DC-SIGN and DC-SIGNR.	Polysaccharides	142-149	C-type lectin domain family 4 member M	Homo sapiens	192-200
11390392-2	2001	IL-2 initially binds a high mannose-type glycan and a specific peptide sequence of the IL-2 receptor alpha-subunit and sequentially forms a high affinity complex of IL-2.IL-2 receptor alpha-, beta-, and gamma-subunits.	Polysaccharides	41-47	interleukin 2	Homo sapiens	0-4
11454642-10	2001	The glycosylation of AGP in the MEFV carrier group, compared with that in a healthy control group, was characterised by a significant increase (p&lt;0.05) in branching of the glycans, whereas the fucosylation remained unaffected.	Polysaccharides	175-182	MEFV innate immuity regulator, pyrin	Homo sapiens	32-36
11463354-3	2001	A striking contrast was that galactose residues were largely beta 1,4-linked to GlcNAc residues in the beta 4Gal-T1(+/+) mouse glycans but beta 1,3-linked in the knockout mouse glycans, thus resulting in the shift of the backbone structure from type 2 chain (Gal beta 1--&gt;4GlcNAc) to type 1 chain (Gal beta 1--&gt;3GlcNAc).	Polysaccharides	127-134	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9	Mus musculus	61-69
11463354-3	2001	A striking contrast was that galactose residues were largely beta 1,4-linked to GlcNAc residues in the beta 4Gal-T1(+/+) mouse glycans but beta 1,3-linked in the knockout mouse glycans, thus resulting in the shift of the backbone structure from type 2 chain (Gal beta 1--&gt;4GlcNAc) to type 1 chain (Gal beta 1--&gt;3GlcNAc).	Polysaccharides	127-134	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	Mus musculus	103-115
11463354-3	2001	A striking contrast was that galactose residues were largely beta 1,4-linked to GlcNAc residues in the beta 4Gal-T1(+/+) mouse glycans but beta 1,3-linked in the knockout mouse glycans, thus resulting in the shift of the backbone structure from type 2 chain (Gal beta 1--&gt;4GlcNAc) to type 1 chain (Gal beta 1--&gt;3GlcNAc).	Polysaccharides	127-134	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9	Mus musculus	61-67
11530211-5	2001	Glycans mediate the interaction of newly synthesized glycoproteins with some resident ER folding factors, such as calnexin and calreticulin.	Polysaccharides	0-7	calreticulin	Homo sapiens	127-139
11487565-3	2001	By using sequence profile analysis, we show that RAD4/Xp-C proteins contain the ancient transglutaminase fold and are specifically related to the recently characterized peptide-N-glycanases (PNGases) which remove glycans from glycoproteins during their degradation.	Polysaccharides	213-220	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	49-53
11500820-1	2001	Haemophilus influenzae type b capsular polysaccharide (PRP) conjugate vaccines, which are thought to induce T cell-dependent antibody production, induce protective responses after a single dose in individuals under 15 months of age.	Polysaccharides	39-53	prion protein	Homo sapiens	55-58
11549423-5	2001	The conjugates elicited boostable IgG responses to fimbriae and serogroup C polysaccharide in mice, and IgG:IgM ratios indicated that the responses were thymus-dependent.	Polysaccharides	76-90	immunoglobulin heavy chain (V7183 family)	Mus musculus	34-37
11487565-3	2001	By using sequence profile analysis, we show that RAD4/Xp-C proteins contain the ancient transglutaminase fold and are specifically related to the recently characterized peptide-N-glycanases (PNGases) which remove glycans from glycoproteins during their degradation.	Polysaccharides	213-220	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	54-58
11457545-3	2001	When the polysaccharides were injected in conjunction with rDNA derived human interleukin 2 (IL-2) the IgG antibody responses were increased in both age groups and memory cells were primed in the younger mice.	Polysaccharides	9-24	interleukin 2	Homo sapiens	78-91
11604107-7	2001	The MIN/3/60 antibody reveals a sub-population of epithelial glycans in the crypts of Lieberkuhn in normal human colon.	Polysaccharides	61-68	CD59 molecule (CD59 blood group)	Homo sapiens	4-9
11501752-4	2001	Enhanced chemiluminescence (ECL) reagent was adopted to estimate the activity of the bound HRP as a measure of the binding affinity of the Fn glycans to lectins, and expressed as luminescent light units (LLU).	Polysaccharides	142-149	fibronectin 1	Homo sapiens	139-141
11454945-0	2001	Liver targeting of interferon-beta with a liver-affinity polysaccharide based on metal coordination in mice.	Polysaccharides	57-71	interferon beta 1, fibroblast	Mus musculus	19-34
11483003-9	2001	Glycan analysis showed that both N-glycan and O-glycan chains were present in rC1INH.	Polysaccharides	0-6	serpin family G member 1	Rattus norvegicus	78-84
11485624-8	2001	Soluble, monomeric gp120 from HIV-1(3N/V1) and wild type virus had identical avidity for the V3 antibody, indicating that the V1 glycans were able to shield V3 only in oligomeric but not monomeric gp120.	Polysaccharides	129-136	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	19-24
11485624-8	2001	Soluble, monomeric gp120 from HIV-1(3N/V1) and wild type virus had identical avidity for the V3 antibody, indicating that the V1 glycans were able to shield V3 only in oligomeric but not monomeric gp120.	Polysaccharides	129-136	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	197-202
11604107-0	2001	A monoclonal antibody, MIN/3/60, that recognizes the sulpho-Lewis(x) and sulpho-Lewis(a) sequences detects a sub-population of epithelial glycans in the crypts of human colonic epithelium.	Polysaccharides	138-145	CD59 molecule (CD59 blood group)	Homo sapiens	23-31
11532280-4	2001	The wide distribution of PCh in polysaccharides of pathogens and in cellular membranes allows CRP to recognize a range of pathogenic targets as well as membranes of damaged and necrotic host cells.	Polysaccharides	32-47	C-reactive protein	Homo sapiens	94-97
11521878-4	2001	Micellar electrokinetic chromatography was used to analytically separate these AT III variants, which differ in their affinity to the polysaccharide heparin.	Polysaccharides	134-148	serpin family C member 1	Homo sapiens	79-85
11457545-3	2001	When the polysaccharides were injected in conjunction with rDNA derived human interleukin 2 (IL-2) the IgG antibody responses were increased in both age groups and memory cells were primed in the younger mice.	Polysaccharides	9-24	interleukin 2	Homo sapiens	93-97
11457545-4	2001	IL-2 increased significantly the IgG antibody response to conjugates of A and C polysaccharides with diphtheria mutant protein but exerted a minimal effect on the IgG response to B polysaccharide complexed with aluminium hydroxide and outer membrane proteins.	Polysaccharides	80-95	interleukin 2	Mus musculus	0-4
11457545-4	2001	IL-2 increased significantly the IgG antibody response to conjugates of A and C polysaccharides with diphtheria mutant protein but exerted a minimal effect on the IgG response to B polysaccharide complexed with aluminium hydroxide and outer membrane proteins.	Polysaccharides	80-94	interleukin 2	Mus musculus	0-4
11457545-5	2001	The stimulatory effect of IL-2 on the antibody responses to the polysaccharide antigens was not mediated by T-cells as similar results were obtained in athymic (nu/nu) and thymocompetent (nu/+) mice.	Polysaccharides	64-78	interleukin 2	Mus musculus	26-30
11444772-3	2001	Enterococcus faecalis has been shown previously to produce an endo-beta-N-acetylglucosaminidase activity which cleaves high mannose-type glycans in glycoproteins between the N-acetylglucosamine residues of the pentasaccharide core.	Polysaccharides	137-144	O-GlcNAcase	Homo sapiens	67-95
11522395-13	2001	Regardless of the results of further preclinical testing for galectin-1, these two case studies break new ground in our understanding how glycans as ligands for lectins convey reactivity to immune cells, with impact on the course of a tumor or autoimmune disease.	Polysaccharides	138-145	galectin 1	Homo sapiens	61-71
11460313-1	2001	In our previous studies, we showed that angelan, a polysaccharide purified from Angelica gigas Nakai, activated macrophages to induce the translocation of NF-kappa B/Rel into nucleus and DNA binding to its cognate site in the promoter of iNOS gene [Immunopharmacology 43 (1999) 1; Immunopharmacology 49 (2000) 275].	Polysaccharides	51-65	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	155-165
11412044-5	2001	Different glycan sites on the same tyrosinase family polypeptide can perform distinct functions, and conserved sites on tyrosinase family paralogues can perform different functions.	Polysaccharides	10-16	tyrosinase	Homo sapiens	35-45
11408923-2	2001	Since cellular glycans play an important role in biological information transfer, we have employed an endogenous lectin, galectin-3, to examine in primary squamous carcinomas, lymph node metastases, and physiological squamous epithelia whether glycans recognized by this lectin are altered in relation to the state of differentiation.	Polysaccharides	15-22	galectin 3	Homo sapiens	121-131
11435503-2	2001	In the rat small intestine, O-glycan: beta-1,3-galactosyltransferase and N-glycan: beta-1,4-galactosyltransferase are, respectively, involved in the glycan chain biosynthesis of mucins and of glycoproteins in the brush border membranes.	Polysaccharides	30-36	glycoprotein alpha-galactosyltransferase 1	Rattus norvegicus	47-68
11509139-9	2001	The influence of Angelica Sinensis Polysaccharides of 60mg/kg was not so obvious as that of 30mg/kg on sGST, NO, cNOS, Bax, and Bcl-2, but was more effective on sALT and iNOS.	Polysaccharides	35-50	nitric oxide synthase 2, inducible	Mus musculus	170-174
11445810-0	2001	A mutation in Bruton"s tyrosine kinase as a cause of selective anti-polysaccharide antibody deficiency.	Polysaccharides	68-82	Bruton tyrosine kinase	Homo sapiens	14-38
11445810-2	2001	We have identified a mutation in the gene encoding Bruton"s tyrosine kinase in a male patient with selective anti-polysaccharide antibody deficiency.	Polysaccharides	114-128	Bruton tyrosine kinase	Homo sapiens	51-75
11488456-3	2001	In the crude polysaccharide fraction (F-2) obtained by EtOH precipitation of the water extract, a significant life-prolonging effect was observed by the administration of 70 mg/kg/day.	Polysaccharides	13-27	coagulation factor II	Mus musculus	38-41
11488456-4	2001	F-2 was further fractionated, and the resulting strongly acidic polysaccharide fraction, F-2-2, had a protective effect at a dose of 17.5 mg/kg/day.	Polysaccharides	64-78	coagulation factor II	Mus musculus	0-3
11488456-4	2001	F-2 was further fractionated, and the resulting strongly acidic polysaccharide fraction, F-2-2, had a protective effect at a dose of 17.5 mg/kg/day.	Polysaccharides	64-78	coagulation factor II	Mus musculus	89-94
11488456-6	2001	The protective activity of F-2-2 was lost by periodate oxidation, but not by protease digestion, suggesting that the polysaccharide component of F-2-2 plays a major role in the protective activity against Candida-infected mice.	Polysaccharides	117-131	coagulation factor II	Mus musculus	27-30
11488456-6	2001	The protective activity of F-2-2 was lost by periodate oxidation, but not by protease digestion, suggesting that the polysaccharide component of F-2-2 plays a major role in the protective activity against Candida-infected mice.	Polysaccharides	117-131	coagulation factor II	Mus musculus	145-148
11294842-10	2001	These studies provide the first direct sequencing data for apo(a) glycans and indicate a novel function for apo(a) O-glycans that is potentially related to the atherogenicity of Lp(a).	Polysaccharides	66-73	lipoprotein(a)	Homo sapiens	59-65
11294842-10	2001	These studies provide the first direct sequencing data for apo(a) glycans and indicate a novel function for apo(a) O-glycans that is potentially related to the atherogenicity of Lp(a).	Polysaccharides	66-73	lipoprotein(a)	Homo sapiens	178-183
11458525-0	2001	Increase in circulating SDF-1 after treatment with sulfated glycans.	Polysaccharides	60-67	chemokine (C-X-C motif) ligand 12	Mus musculus	24-29
11279053-3	2001	MAG has a sialic acid binding site in its N-terminal domain and binds to specific sialylated glycans and gangliosides present on the surface of neurons, but the significance of these interactions in the effect of MAG on neurite outgrowth is unclear.	Polysaccharides	93-100	myelin associated glycoprotein	Homo sapiens	0-3
11279053-4	2001	Here we present evidence to suggest that recognition of sialylated glycans is essential for inhibition of neurite outgrowth by MAG.	Polysaccharides	67-74	myelin associated glycoprotein	Homo sapiens	127-130
11458525-7	2001	In vitro, these sulfated glycans specifically bind to SDF-1 and inhibit SDF-1/heparin binding, suggesting a mechanism of release from sequestration on heparan sulfate proteoglycans in vivo.	Polysaccharides	25-32	chemokine (C-X-C motif) ligand 12	Mus musculus	54-59
11458525-7	2001	In vitro, these sulfated glycans specifically bind to SDF-1 and inhibit SDF-1/heparin binding, suggesting a mechanism of release from sequestration on heparan sulfate proteoglycans in vivo.	Polysaccharides	25-32	chemokine (C-X-C motif) ligand 12	Mus musculus	72-77
11458525-12	2001	Our data offer a unique insight into the mechanism of sulfated glycan-induced mobilization and suggest a novel way of disturbing SDF-1 gradients between bone marrow and peripheral blood.	Polysaccharides	63-69	chemokine (C-X-C motif) ligand 12	Mus musculus	129-134
11348704-1	2001	Haemophilus influenzae type b (Hib) capsular polysaccharide (polyribosylribitol phosphate, PRP) is the active component of conjugate vaccines that have proven successful in preventing invasive Hib disease.	Polysaccharides	45-59	major prion protein	Oryctolagus cuniculus	91-94
11677785-6	2001	Glycans were enzymatically released from alpha 1-antitrypsin which had been separated in gels formed with a low percentage of bis-acrylamide cross-linker and analysed.	Polysaccharides	0-7	serpin family A member 1	Homo sapiens	41-60
11356201-9	2001	More truncated glycans were richer in PHF-tau than AD P-tau.	Polysaccharides	15-22	microtubule associated protein tau	Homo sapiens	38-45
11393703-4	2001	Moreover, the application of neuraminidase treatment revealed that complex biantennary type glycans, present on lysosomal beta-glucuronidase, are almost fully sialylated while the same type of glycans present on microsomal enzyme do not contain sialic acid.	Polysaccharides	92-99	glucuronidase, beta	Rattus norvegicus	122-140
11331020-6	2001	Different polysaccharide acceptor substrates were incubated with cell extracts from 2-OST-transfected 293 cells together with the sulfate donor 3"-phosphoadenosine 5"-phospho[(35)S]sulfate.	Polysaccharides	10-24	uronyl 2-sulfotransferase	Homo sapiens	84-89
11465091-1	2001	X-linked immunodeficient (Xid) mice carry a Bruton"s tyrosine kinase (Btk) mutation and exhibit a selective failure to produce antibodies against bacterial capsular polysaccharides.	Polysaccharides	165-180	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	0-24
11465091-1	2001	X-linked immunodeficient (Xid) mice carry a Bruton"s tyrosine kinase (Btk) mutation and exhibit a selective failure to produce antibodies against bacterial capsular polysaccharides.	Polysaccharides	165-180	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	26-29
11465091-3	2001	We describe results from a novel model, which we have used to investigate the impact of the Xid mutation on migration, proliferation and differentiation of B cells after polysaccharide immunization in vivo.	Polysaccharides	170-184	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	92-95
11304796-4	2001	Although alpha4GnT plays a key role in producing this unique glycan in vitro, the actual localization of alpha4GnT was not determined.	Polysaccharides	61-67	alpha-1,4-N-acetylglucosaminyltransferase	Homo sapiens	9-18
11425798-6	2001	Non-PSA/HNK1-glycans exhibited a highly heterogeneous pattern of partially truncated, mostly diantennary structures being characterized by the presence of additional fucose, bisecting GlcNAc and/or sulfate residues.	Polysaccharides	13-20	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	8-12
11292721-0	2001	Increased immunogenicity and induction of class switching by conjugation of complement C3d to pneumococcal serotype 14 capsular polysaccharide.	Polysaccharides	128-142	complement component 3	Mus musculus	76-89
11152460-1	2001	B-cell-specific CD22 is a member of a group of cell adhesion molecules within the immunoglobulin superfamily that display binding to glycans with terminal sialic acid residues.	Polysaccharides	133-140	CD22 molecule	Homo sapiens	16-20
11278604-16	2001	They may be used in glycosylation engineering and in investigating roles for beta4GalT-1 and beta4GalT-6 in generating specific glycan ligands.	Polysaccharides	128-134	beta-1,4-galactosyltransferase 1	Cricetulus griseus	77-88
11359567-4	2001	One MAN1 disruption mutant, man1, which showed poor capsule formation, reduced polysaccharide secretion and morphological abnormalities, was chosen for virulence studies.	Polysaccharides	79-93	LEM domain containing 3	Homo sapiens	28-32
11322734-5	2001	Reactivity of the polysaccharide C-atoms was determined by 13C NMR spectroscopy: For dextran this was C-3 &gt; C-2 &gt; C-4, while for pullulan it was C-6 &gt; C-3 &gt; C-2 &gt; C-4.	Polysaccharides	18-32	complement C3	Homo sapiens	102-105
11301188-0	2001	Pro-apoptotic and anti-apoptotic effects of transferrin and transferrin-derived glycans on hematopoietic cells and lymphocytes.	Polysaccharides	80-87	transferrin	Mus musculus	60-71
11240858-5	2001	The IL-8 production activity of polysaccharide from P. gingivalis was higher than that of other cell-surface components.	Polysaccharides	32-46	C-X-C motif chemokine ligand 8	Homo sapiens	4-8
11290756-7	2001	Similarly, fucoidan, a sulfated polysaccharide that binds to L-selectin CBD, inhibited the Ca(2+) signal.	Polysaccharides	32-46	selectin L	Homo sapiens	61-71
11300755-7	2001	PrP(Sc) from the brains of Syrian hamsters contains the same set of glycans as PrP(C), but a higher proportion of tri- and tetra-antennary sugars.	Polysaccharides	68-75	major prion protein	Mesocricetus auratus	0-3
11308323-1	2001	Post-translational glycosylation of bovine beta-casein (L70S/P71S) that results in Asn(68)-linked glycan on the protein was obtained in up to 30% of total beta-casein expressed in the methylotrophic yeast Pichia pastoris.	Polysaccharides	98-104	casein beta	Bos taurus	43-54
11308323-1	2001	Post-translational glycosylation of bovine beta-casein (L70S/P71S) that results in Asn(68)-linked glycan on the protein was obtained in up to 30% of total beta-casein expressed in the methylotrophic yeast Pichia pastoris.	Polysaccharides	98-104	casein beta	Bos taurus	155-166
11308363-4	2001	The attachment of polysaccharide to native lysozyme and soybean P34 protein using the Maillard-type reaction was also found to be effective in reducing the production level of IgE compared to IgG.	Polysaccharides	18-32	P34 probable thiol protease	Glycine max	64-67
11254728-7	2001	A mAb to S100A9 blocked neutrophil binding to immobilized carboxylated glycans.	Polysaccharides	71-78	S100 calcium binding protein A9	Homo sapiens	9-15
11254728-8	2001	Purified human S100A8/A9 complex and recombinant human annexin I showed carboxylate-dependent binding to immobilized bovine lung carboxylated glycans and recognized a subset of mannose-labeled endothelial glycoproteins immunoprecipitated by mAbGB3.1.	Polysaccharides	142-149	S100 calcium binding protein A8	Homo sapiens	15-21
11388609-1	2001	Although polysaccharide intercellular adhesin (PIA) is thought to be crucial in the pathogenesis of prosthetic device infections caused by Staphylococcus epidermidis, its role in prosthetic device infections caused by Staphylococcus aureus is unknown.	Polysaccharides	9-23	AT695_RS03940	Staphylococcus aureus	38-45
11322734-5	2001	Reactivity of the polysaccharide C-atoms was determined by 13C NMR spectroscopy: For dextran this was C-3 &gt; C-2 &gt; C-4, while for pullulan it was C-6 &gt; C-3 &gt; C-2 &gt; C-4.	Polysaccharides	18-32	complement C2	Homo sapiens	111-114
11322734-5	2001	Reactivity of the polysaccharide C-atoms was determined by 13C NMR spectroscopy: For dextran this was C-3 &gt; C-2 &gt; C-4, while for pullulan it was C-6 &gt; C-3 &gt; C-2 &gt; C-4.	Polysaccharides	18-32	complement C4A (Rodgers blood group)	Homo sapiens	120-123
11114299-8	2001	Furthermore, DC-HIL appears to recognize directly these sulfated polysaccharides.	Polysaccharides	65-80	glycoprotein (transmembrane) nmb	Mus musculus	13-19
11322734-5	2001	Reactivity of the polysaccharide C-atoms was determined by 13C NMR spectroscopy: For dextran this was C-3 &gt; C-2 &gt; C-4, while for pullulan it was C-6 &gt; C-3 &gt; C-2 &gt; C-4.	Polysaccharides	18-32	complement C6	Homo sapiens	151-154
11322734-5	2001	Reactivity of the polysaccharide C-atoms was determined by 13C NMR spectroscopy: For dextran this was C-3 &gt; C-2 &gt; C-4, while for pullulan it was C-6 &gt; C-3 &gt; C-2 &gt; C-4.	Polysaccharides	18-32	complement C3	Homo sapiens	160-163
11322734-5	2001	Reactivity of the polysaccharide C-atoms was determined by 13C NMR spectroscopy: For dextran this was C-3 &gt; C-2 &gt; C-4, while for pullulan it was C-6 &gt; C-3 &gt; C-2 &gt; C-4.	Polysaccharides	18-32	complement C2	Homo sapiens	169-172
11322734-5	2001	Reactivity of the polysaccharide C-atoms was determined by 13C NMR spectroscopy: For dextran this was C-3 &gt; C-2 &gt; C-4, while for pullulan it was C-6 &gt; C-3 &gt; C-2 &gt; C-4.	Polysaccharides	18-32	complement C4A (Rodgers blood group)	Homo sapiens	178-181
11238599-7	2001	Finally, sialoadhesin bound different glycoforms of CD43 expressed in Chinese hamster ovary cells, including unbranched (core 1) and branched (core 2) O:-linked glycans, that are normally found on CD43 in resting and activated T cells, respectively.	Polysaccharides	161-168	sialoadhesin	Cricetulus griseus	9-21
11396133-0	2001	Plant polysaccharide PSK: cytostatic effects on growth and invasion; modulating effect on the expression of HLA and adhesion molecules on human gastric and colonic tumor cell surface.	Polysaccharides	6-20	TAO kinase 2	Homo sapiens	21-24
11076950-1	2001	Interleukin-2 (IL-2) specifically recognizes high-mannose type glycans with five or six mannosyl residues.	Polysaccharides	63-70	interleukin 2	Mus musculus	0-13
11076950-1	2001	Interleukin-2 (IL-2) specifically recognizes high-mannose type glycans with five or six mannosyl residues.	Polysaccharides	63-70	interleukin 2	Mus musculus	15-19
11076950-2	2001	To determine whether the carbohydrate recognition activity of IL-2 contributes to its physiological activity, the inhibitory effects of high-mannose type glycans on IL-2-dependent CTLL-2 cell proliferation were investigated.	Polysaccharides	154-161	interleukin 2	Mus musculus	165-169
11076950-5	2001	Among the components of this complex, only the IL-2 receptor alpha subunit was stained with Galanthus nivalis agglutinin which specifically recognizes high-mannose type glycans.	Polysaccharides	169-176	interleukin 2 receptor subunit alpha	Homo sapiens	47-66
11076950-6	2001	This staining was diminished after digestion of the glycans with endo-beta-N-acetylglucosaminidase H or D, suggesting that at least a N-glycan containing Man(5)GlcNAc(2) is linked to the extracellular portion of the IL-2 receptor alpha subunit.	Polysaccharides	52-59	interleukin 2 receptor subunit alpha	Homo sapiens	216-235
11396133-1	2001	PSK is a plant polysaccharide widely used for cancer immunotherapy in Japan and other Asian countries.	Polysaccharides	15-29	TAO kinase 2	Homo sapiens	0-3
11301856-2	2001	A high output nitric oxide synthase (iNOS) was shown in female BALB/c mice administered intraperitoneally with the acidic polysaccharide from ginseng.	Polysaccharides	122-136	nitric oxide synthase 2, inducible	Mus musculus	37-41
11171414-10	2001	These results led us to investigate the possible occurrence of a highly sulphated polysaccharide on vesicles from the SR of sea cucumber smooth muscle that could act as an "endogenous" Ca(2+)-ATPase inhibitor.	Polysaccharides	82-96	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	124-127
11171414-11	2001	In fact, SR vesicles derived from the sea cucumber, but not from rabbit muscle, contain a highly sulphated polysaccharide.	Polysaccharides	107-121	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	38-41
11171414-14	2001	These results strongly suggest that the sea cucumber Ca(2+)-ATPase is activated by monovalent cations because of the presence of endogenous sulphated polysaccharides.	Polysaccharides	150-165	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	40-43
11238201-0	2001	Up-regulation of CD40 ligand and induction of a Th2 response in children immunized with pneumococcal polysaccharide vaccines.	Polysaccharides	101-115	CD40 molecule	Homo sapiens	17-21
11301856-3	2001	Newly synthesized iNOS protein was also observed in peritoneal macrophages cultured with interferon-gamma and the acidic polysaccharide.	Polysaccharides	121-135	nitric oxide synthase 2, inducible	Mus musculus	18-22
11301856-5	2001	The treatment of mice with aminoguanidine, a specific iNOS inhibitor, alleviated the acidic polysaccharide-induced suppression of antibody response to sheep red blood cells.	Polysaccharides	92-106	nitric oxide synthase 2, inducible	Mus musculus	54-58
11226227-6	2001	Mutant cyt1 embryos are deficient in N-glycosylation and have an altered composition of cell wall polysaccharides.	Polysaccharides	98-113	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	7-11
11305514-3	2001	The objective of the present study was to re-evaluate the potential role of selectins in experimental colitis in wild-type mice using the polysaccharide fucoidan, which inhibits the function of P- and L-selectin.	Polysaccharides	138-152	selectin, lymphocyte	Mus musculus	201-211
11217864-8	2001	These data indicate that a galectin-glycoprotein lattice strengthened by Mgat5-modified glycans restricts TCR recruitment to the site of antigen presentation.	Polysaccharides	88-95	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	73-78
11342172-0	2001	Glycans are involved in RANTES binding to CCR5 positive as well as to CCR5 negative cells.	Polysaccharides	0-7	C-C motif chemokine receptor 5	Homo sapiens	42-46
11342172-0	2001	Glycans are involved in RANTES binding to CCR5 positive as well as to CCR5 negative cells.	Polysaccharides	0-7	C-C motif chemokine receptor 5	Homo sapiens	70-74
11342172-1	2001	We show that cell surface glycans, sialic acid and mannose-containing species, are involved beside glycosaminoglycans (GAGs), heparan sulfate and chondroitin sulfate in the binding of full length (1--68) RANTES not only to CCR5 positive human primary lymphocytes or macrophages but also to CCR5 negative monocytic U937 cells.	Polysaccharides	26-33	C-C motif chemokine receptor 5	Homo sapiens	223-227
11342172-1	2001	We show that cell surface glycans, sialic acid and mannose-containing species, are involved beside glycosaminoglycans (GAGs), heparan sulfate and chondroitin sulfate in the binding of full length (1--68) RANTES not only to CCR5 positive human primary lymphocytes or macrophages but also to CCR5 negative monocytic U937 cells.	Polysaccharides	26-33	C-C motif chemokine receptor 5	Homo sapiens	290-294
11166896-5	2001	We have defined a peptide sequence (pep4) that mimics the S. pneumoniae serotype 4 capsular polysaccharide (PPS4) using a monoclonal antibody to PPS4 (mAb4) and phage display library.	Polysaccharides	92-106	peptidase D	Mus musculus	36-40
11166896-5	2001	We have defined a peptide sequence (pep4) that mimics the S. pneumoniae serotype 4 capsular polysaccharide (PPS4) using a monoclonal antibody to PPS4 (mAb4) and phage display library.	Polysaccharides	92-106	immunoglobulin kappa variable 4-62	Mus musculus	151-155
11016923-7	2001	The nature of the cathepsin B-glycosaminoglycans interaction was sensitive to the charge and type of polysaccharide.	Polysaccharides	101-115	cathepsin B	Homo sapiens	18-29
11157270-1	2001	We describe a rapid and efficient method for producing the capsular polysaccharide of Streptococcus pneumoniae by fermentation on tryptic soy broth and purification of this compound by using immobilized soybean lectin as an affinity adsorbent.	Polysaccharides	68-82	LOW QUALITY PROTEIN: lectin	Glycine max	211-217
11157270-2	2001	In principle, the same strategy can be used to produce purified capsular polysaccharides from other streptococcal serotypes by selecting the appropriate lectin adsorbents.	Polysaccharides	73-88	LOW QUALITY PROTEIN: lectin	Glycine max	129-135
11288979-3	2001	We tested the hypothesis that the TSHR 50 amino acid insertion was further downstream than we previously concluded, a possibility that would relocate the crucial LH/CGR glycan at N291 relative to the position of the TSHR insertion, and that would mitigate against the 50 amino acid insertion playing a role in TSHR intramolecular cleavage.	Polysaccharides	169-175	thyroid stimulating hormone receptor	Homo sapiens	34-38
11288979-3	2001	We tested the hypothesis that the TSHR 50 amino acid insertion was further downstream than we previously concluded, a possibility that would relocate the crucial LH/CGR glycan at N291 relative to the position of the TSHR insertion, and that would mitigate against the 50 amino acid insertion playing a role in TSHR intramolecular cleavage.	Polysaccharides	169-175	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	162-168
11288979-4	2001	Thus, we transferred the LH/CGR glycan at amino acid 291 from downstream (N367) to upstream of the 50 amino acid insertion (N317) in the TSHR, leaving this insertion intact.	Polysaccharides	32-38	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	25-31
11361003-2	2001	In this study, rate constants and dissociation constants of 125I-ferri-transferrin binding to the human TfR were examined dependent on receptor glycan composition, pH, bivalent cations, and temperature.	Polysaccharides	144-150	transferrin	Homo sapiens	71-82
11361003-2	2001	In this study, rate constants and dissociation constants of 125I-ferri-transferrin binding to the human TfR were examined dependent on receptor glycan composition, pH, bivalent cations, and temperature.	Polysaccharides	144-150	transferrin receptor	Homo sapiens	104-107
11360925-1	2001	In our previous studies, we showed that angelan, a polysaccharide purified from Angelica gigas Nakai, specifically activated macrophages to induce cytokines including inducible nitric oxide synthase (iNOS) which has strong anti-tumor activities [Immunopharmacology, 1999; 43: 1.].	Polysaccharides	51-65	nitric oxide synthase 2, inducible	Mus musculus	200-204
11152606-5	2001	This dual carbohydrate binding specificity enables MR to bind ligands by interacting with both sulfated and non-sulfated polysaccharide chains.	Polysaccharides	121-135	mannose receptor C-type 1	Homo sapiens	51-53
11020386-2	2001	We have studied the effect of macromolecular crowding reagents, such as polysaccharides and bovine serum albumin, on the refolding of tetradecameric GroEL from urea-denatured protein monomers.	Polysaccharides	72-87	heat shock protein family D (Hsp60) member 1	Homo sapiens	149-154
14533804-0	2001	Biosynthesis and function of beta 1,6 branched mucin-type glycans.	Polysaccharides	58-65	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	29-35
14533804-0	2001	Biosynthesis and function of beta 1,6 branched mucin-type glycans.	Polysaccharides	58-65	LOC100508689	Homo sapiens	47-52
14533804-5	2001	The family of enzymes which creates beta1,6 branched structure in mucin glycans is proving to be quite complex, since multiple isoforms appear to exist for these enzymes, and some of the enzymes are adept at forming more than one type of beta1,6 branched structure, as in the case of C2GnT-M.	Polysaccharides	72-79	glucosaminyl (N-acetyl) transferase 3, mucin type	Homo sapiens	284-291
14533804-3	2001	For instance, synthesis of the core 2 beta1,6 branched structure in the mucin glycan chain by C2GnT enables the expression of functional structures at the termini of polylactosamine chains, such as blood group antigens and sialyl Lewis x.	Polysaccharides	78-84	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	38-45
14533817-0	2001	T-independent IgA responses to microbial polysaccharides.	Polysaccharides	41-56	CD79a molecule	Homo sapiens	14-17
14533804-3	2001	For instance, synthesis of the core 2 beta1,6 branched structure in the mucin glycan chain by C2GnT enables the expression of functional structures at the termini of polylactosamine chains, such as blood group antigens and sialyl Lewis x.	Polysaccharides	78-84	LOC100508689	Homo sapiens	72-77
14533804-3	2001	For instance, synthesis of the core 2 beta1,6 branched structure in the mucin glycan chain by C2GnT enables the expression of functional structures at the termini of polylactosamine chains, such as blood group antigens and sialyl Lewis x.	Polysaccharides	78-84	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	94-99
14533804-5	2001	The family of enzymes which creates beta1,6 branched structure in mucin glycans is proving to be quite complex, since multiple isoforms appear to exist for these enzymes, and some of the enzymes are adept at forming more than one type of beta1,6 branched structure, as in the case of C2GnT-M.	Polysaccharides	72-79	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	36-43
14533804-5	2001	The family of enzymes which creates beta1,6 branched structure in mucin glycans is proving to be quite complex, since multiple isoforms appear to exist for these enzymes, and some of the enzymes are adept at forming more than one type of beta1,6 branched structure, as in the case of C2GnT-M.	Polysaccharides	72-79	LOC100508689	Homo sapiens	66-71
14533804-5	2001	The family of enzymes which creates beta1,6 branched structure in mucin glycans is proving to be quite complex, since multiple isoforms appear to exist for these enzymes, and some of the enzymes are adept at forming more than one type of beta1,6 branched structure, as in the case of C2GnT-M.	Polysaccharides	72-79	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	238-245
11156607-7	2001	Subcellular localization of the KOJAK/AtCSLD3 protein using a GFP fusion shows that KOJAK/AtCSLD3 is located on the endoplasmic reticulum, indicating that KOJAK/AtCSLD3 is required for the synthesis of a noncellulosic wall polysaccharide.	Polysaccharides	223-237	cellulose synthase-like D3	Arabidopsis thaliana	32-37
11114593-7	2001	Recent structural data indicates that the glycan sequences implicated in mediating murine gamete recognition are also expressed on CD45 in activated murine T lymphocytes and cytotoxic T lymphocytes.	Polysaccharides	42-48	protein tyrosine phosphatase, receptor type, C	Mus musculus	131-135
11156607-7	2001	Subcellular localization of the KOJAK/AtCSLD3 protein using a GFP fusion shows that KOJAK/AtCSLD3 is located on the endoplasmic reticulum, indicating that KOJAK/AtCSLD3 is required for the synthesis of a noncellulosic wall polysaccharide.	Polysaccharides	223-237	cellulose synthase-like D3	Arabidopsis thaliana	38-45
11156607-7	2001	Subcellular localization of the KOJAK/AtCSLD3 protein using a GFP fusion shows that KOJAK/AtCSLD3 is located on the endoplasmic reticulum, indicating that KOJAK/AtCSLD3 is required for the synthesis of a noncellulosic wall polysaccharide.	Polysaccharides	223-237	cellulose synthase-like D3	Arabidopsis thaliana	84-89
11156607-7	2001	Subcellular localization of the KOJAK/AtCSLD3 protein using a GFP fusion shows that KOJAK/AtCSLD3 is located on the endoplasmic reticulum, indicating that KOJAK/AtCSLD3 is required for the synthesis of a noncellulosic wall polysaccharide.	Polysaccharides	223-237	cellulose synthase-like D3	Arabidopsis thaliana	90-97
11156607-7	2001	Subcellular localization of the KOJAK/AtCSLD3 protein using a GFP fusion shows that KOJAK/AtCSLD3 is located on the endoplasmic reticulum, indicating that KOJAK/AtCSLD3 is required for the synthesis of a noncellulosic wall polysaccharide.	Polysaccharides	223-237	cellulose synthase-like D3	Arabidopsis thaliana	84-89
11156607-7	2001	Subcellular localization of the KOJAK/AtCSLD3 protein using a GFP fusion shows that KOJAK/AtCSLD3 is located on the endoplasmic reticulum, indicating that KOJAK/AtCSLD3 is required for the synthesis of a noncellulosic wall polysaccharide.	Polysaccharides	223-237	cellulose synthase-like D3	Arabidopsis thaliana	90-97
11800271-5	2001	In C. albicans, the glycan can be delineated into an inner mannan core, which is similar to mammalian glycoproteins, an alpha-linked mannan backbone with alpha-oligomannosyl side chains, and beta(1,2)-oligomannosides which are phosphodiester linked to the alpha-mannan.	Polysaccharides	20-26	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	191-199
16233148-2	2001	N-Acetylglucosaminyltransferase I (GnT-I), which catalyzes the transfer of an N-acetylglucosamine residue from UDP-N-acetylglucosamine to the alpha1,3-linked mannose on Man5GlcNAc2 (M5), is a critical enzyme for the synthesis of high-mannose-type to complex-type glycan structures in N-linked glycan processing.	Polysaccharides	263-269	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	35-40
11800269-1	2001	The polysaccharide beta(1,3)-D-glucan is a component of the cell wall of many fungi.	Polysaccharides	4-18	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	19-27
11007797-10	2000	Our data show that Fuc-TV worked well with a very wide range of LN-glycans, showing weak reactivity only with distal (sialyl)LN units of i-type polylactosamines, biantennary N-glycans, and I branches of polylactosamines.	Polysaccharides	67-74	fucosyltransferase 5	Homo sapiens	19-25
11302201-3	2001	About 75% of charged haptoglobin glycans were of biantennary complex structure, and some of them lacked one terminal sialic acid molecule.	Polysaccharides	33-40	haptoglobin	Homo sapiens	21-32
11167020-8	2000	Similarity of the EP58 sequence with bacterial and fungus proteins suggests a possible role for EP58 in polysaccharide biosynthesis.	Polysaccharides	104-118	protein O-glucosyltransferase 2	Homo sapiens	18-22
11167020-8	2000	Similarity of the EP58 sequence with bacterial and fungus proteins suggests a possible role for EP58 in polysaccharide biosynthesis.	Polysaccharides	104-118	protein O-glucosyltransferase 2	Homo sapiens	96-100
11345535-7	2001	In addition, 7D5 immunoprecipitated the approximately 58 kDa unglycosylated gp91phox protein from solubilized membrane fractions of tunicamycin-treated PLB-985 granulocytes, indicating that glycans were not required for 7D5 binding.	Polysaccharides	190-197	cytochrome b-245 beta chain	Homo sapiens	76-84
11528254-6	2001	The latter reacts with a certain glycoform of the MUC1 peptide core, characterized by core-type glycans like TF.	Polysaccharides	96-103	mucin 1, cell surface associated	Homo sapiens	50-54
11344537-4	2001	In a single measurement of previously chemically untreated O-fucosylated peptides originating from the thrombospondin-1 repeats, we were able to determine the glycosylation status of the analyzed peptide, the glycosylation site, and the glycan structure.	Polysaccharides	237-243	thrombospondin 1	Homo sapiens	103-119
11137252-0	2000	Serotype of Streptococcus pneumoniae capsular polysaccharide can modify the Th1/Th2 cytokine profile and IgG subclass response to pneumococal-CRM(197) conjugate vaccines in a murine model.	Polysaccharides	46-60	negative elongation factor complex member C/D, Th1l	Mus musculus	76-79
11142416-0	2000	Neonatal inoculation with the protein-bound polysaccharide PSK increases resistance of adult animals to challenge with syngeneic tumor cells and reduces azoxymethane-induced precancerous lesions in the colon.	Polysaccharides	44-58	TAO kinase 2	Mus musculus	59-62
11142416-1	2000	We have investigated the results of neonatal inoculation with a protein-bound polysaccharide, PSK, as it affects the defense mechanism of animals against cancer.	Polysaccharides	78-92	TAO kinase 2	Mus musculus	94-97
11137252-0	2000	Serotype of Streptococcus pneumoniae capsular polysaccharide can modify the Th1/Th2 cytokine profile and IgG subclass response to pneumococal-CRM(197) conjugate vaccines in a murine model.	Polysaccharides	46-60	heart and neural crest derivatives expressed 2	Mus musculus	80-83
11117312-5	2000	The generation of glycoside-primed glycans altered the formation of glycoproteins on the cell surface and inhibited cell adhesion dependent on E-selectin.	Polysaccharides	35-42	selectin E	Homo sapiens	143-153
11446374-4	2000	Ficolin/P35 bound to an Ra chemotype strain of Salmonella typhimurium (TV119) which has an exposed GlcNAc at the non-reducing termini of the polysaccharide.	Polysaccharides	141-155	ficolin 2	Homo sapiens	8-11
11069996-0	2000	The N-terminal V3 loop glycan modulates the interaction of clade A and B human immunodeficiency virus type 1 envelopes with CD4 and chemokine receptors.	Polysaccharides	23-29	CD4 molecule	Homo sapiens	124-127
11069996-1	2000	We investigated the underlying mechanism by which the highly conserved N-terminal V3 loop glycan of gp120 conferred resistance to neutralization of human immunodeficiency virus type 1 (HIV-1).	Polysaccharides	90-96	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	100-105
11067926-4	2000	We demonstrate that the presence of untrimmed N-linked core glycans (Glc(3)Man(9)GlcNAc(2)) on the FcepsilonRI alpha-chain activates the ER quality control mechanism to retain this subunit in the ER, despite the presence of gamma-chains.	Polysaccharides	60-67	Fc epsilon receptor Ia	Homo sapiens	99-116
11205205-0	2000	Immunoregulatory effects of the antitumor polysaccharide lentinan on Th1/Th2 balance in patients with digestive cancers.	Polysaccharides	42-56	negative elongation factor complex member C/D	Homo sapiens	69-72
11090208-6	2000	In addition, pectin, a complex polysaccharide important for cell adhesion, appears to be abnormally localized in emb30 plants.	Polysaccharides	31-45	sec7 domain-containing protein	Arabidopsis thaliana	113-118
11044358-4	2000	Recently, we have characterized the predominant glycans of human serum AFP and now report the application of these findings and electrospray ionization-mass spectrometry (ESI-MS) to the determination of the glycan composition of the isoforms present in the sera of 12 patients with HCC and of one patient with NSGCT.	Polysaccharides	48-55	alpha fetoprotein	Homo sapiens	71-74
11205261-4	2000	Simultaneously multiple injections with the polysaccharides reduced the increases in thymidylate synthase and thymidine kinase activities and a number of bromodeoxyuridine-incorporated S-phase cells in colorectal tissues resulted in the reduction of tumorous regions with high-grade dysplasia.	Polysaccharides	44-59	thymidylate synthetase	Homo sapiens	85-105
11044358-4	2000	Recently, we have characterized the predominant glycans of human serum AFP and now report the application of these findings and electrospray ionization-mass spectrometry (ESI-MS) to the determination of the glycan composition of the isoforms present in the sera of 12 patients with HCC and of one patient with NSGCT.	Polysaccharides	48-54	alpha fetoprotein	Homo sapiens	71-74
11369259-4	2000	This article reviews recent structural, mutagenesis and kinetic data that lead to identification of this exosite and discusses how the binding of protein or polysaccharide cofactors to this site of factor Xa can modulate the specificity and physiological function of this key coagulant enzyme in plasma.	Polysaccharides	157-171	coagulation factor X	Homo sapiens	198-207
11112858-3	2000	A sensitive method has been developed for analysing the structures of the glycan chains of individual glycoprotein allergens transferred to blots following two-dimensional PAGE, and has allowed the structural identification of the glycan chains of the most abundant isoforms of Equ c 1, a glycosylated horse dander major allergen.	Polysaccharides	74-80	major allergen Equ c 1	Equus caballus	278-285
11112858-3	2000	A sensitive method has been developed for analysing the structures of the glycan chains of individual glycoprotein allergens transferred to blots following two-dimensional PAGE, and has allowed the structural identification of the glycan chains of the most abundant isoforms of Equ c 1, a glycosylated horse dander major allergen.	Polysaccharides	231-237	major allergen Equ c 1	Equus caballus	278-285
11027230-8	2000	In addition, subsets of OCAM(+) axons that normally project to the ventrolateral OB and some lactosamine-containing glycan(+) axons that normally target the ventral OB are also misrouted in Sema3A mutants.	Polysaccharides	116-122	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	190-196
10942758-5	2000	Like parent P2X(1), glycan minus mutants migrate as homotrimers when resolved by blue native PAGE.	Polysaccharides	20-26	purinergic receptor P2X 1	Rattus norvegicus	12-18
11068879-8	2000	Interestingly, the radioactive peaks resolved from mZP2 and mZP3 were quite different, a result suggesting qualitative and quantitative differences in the glycans.	Polysaccharides	155-162	zona pellucida glycoprotein 2	Mus musculus	51-55
11068879-8	2000	Interestingly, the radioactive peaks resolved from mZP2 and mZP3 were quite different, a result suggesting qualitative and quantitative differences in the glycans.	Polysaccharides	155-162	zona pellucida glycoprotein 3	Mus musculus	60-64
11068879-9	2000	The [SH]-labeled glycans present in mZP2 and mZP3 were pooled separately and fractionated by serial lectin chromatography.	Polysaccharides	17-24	zona pellucida glycoprotein 2	Mus musculus	36-40
11068879-9	2000	The [SH]-labeled glycans present in mZP2 and mZP3 were pooled separately and fractionated by serial lectin chromatography.	Polysaccharides	17-24	zona pellucida glycoprotein 3	Mus musculus	45-49
11068879-11	2000	The mZP3 glycans eluted from the immobilized lectin columns were further characterized by lectin and sizing column chromatography before or after digestion with endo-/ exo-glycohydrolases.	Polysaccharides	9-16	zona pellucida glycoprotein 3	Mus musculus	4-8
11425189-0	2000	Alkali-catalyzed beta-elimination of periodate-oxidized glycans: a novel method of chemical deglycosylation of mucin gene products in paraffin embedded sections.	Polysaccharides	56-63	LOC100508689	Homo sapiens	111-116
11030742-4	2000	The results suggest the structured part of the protein, HU:PrP(127-227) is stabilized overall from addition of the glycans, specifically by extensions of Helix-B and Helix-C and reduced flexibility of the linking turn containing Asn197, although some regions such as residues in the turn (165-170) between Strand-B and Helix-B have increased flexibility.	Polysaccharides	115-122	prion protein	Homo sapiens	59-62
11030750-5	2000	The GDP-L-fucose product could be used as the fucose donor for alpha1,3fucosyltransferase to synthesize sialyl Lewis x (sLex), a glycan crucial for the selectin-dependent leukocyte traffic.	Polysaccharides	129-135	fucosyltransferase 11	Homo sapiens	63-89
11017914-0	2000	Endothelial sulfated sialyl Lewis x glycans, putative L-selectin ligands, are preferentially expressed in bronchial asthma but not in other chronic inflammatory lung diseases.	Polysaccharides	36-43	selectin L	Homo sapiens	54-64
11017914-8	2000	These data suggest that sulfated sLex glycans, acting putatively as ligands for L-selectin, could be instrumental in lymphocyte extravasation into human peribronchial lung tissue during asthma, but not so important in several other inflammatory lung diseases.	Polysaccharides	38-45	selectin L	Homo sapiens	80-90
11001898-10	2000	Our results indicate that administration of sulfated glycans, especially with concurrent inhibition of E-selectin function, represents a powerful novel method for rapid mobilization of long-term-repopulating stem cells.	Polysaccharides	53-60	selectin, endothelial cell	Mus musculus	103-113
11014210-8	2000	Elimination of this glycan (N302Q substitution) reversed the effect of deleting amino acid residues 305-320 on TSHR cleavage, suggesting that reduced cleavage at the new, upstream cleavage site was caused by steric hindrance by the glycan at N302.	Polysaccharides	20-26	thyroid stimulating hormone receptor	Homo sapiens	111-115
11014210-9	2000	In summary, deletion, as opposed to mutagenesis, of the TSHR cleavage Site 1 region produces a spatial shift in TSHR cleavage Site 1 from downstream to upstream of the glycan at N302.	Polysaccharides	168-174	thyroid stimulating hormone receptor	Homo sapiens	56-60
11014210-9	2000	In summary, deletion, as opposed to mutagenesis, of the TSHR cleavage Site 1 region produces a spatial shift in TSHR cleavage Site 1 from downstream to upstream of the glycan at N302.	Polysaccharides	168-174	thyroid stimulating hormone receptor	Homo sapiens	112-116
11024352-5	2000	Polysaccharide (PS) moiety of LPS stimulated the nitrite release of elicited macrophages by 1.6-fold compared to untreated control.	Polysaccharides	0-14	toll-like receptor 4	Mus musculus	30-33
11024352-5	2000	Polysaccharide (PS) moiety of LPS stimulated the nitrite release of elicited macrophages by 1.6-fold compared to untreated control.	Polysaccharides	16-18	toll-like receptor 4	Mus musculus	30-33
11425189-7	2000	We conclude that this novel chemical deglycosylation method that causes selective cleavage of distinct glycans will be useful in unmasking various mucin gene products and glycoproteins containing similar O-glycosidic linkages in the tissue sections of formalin-fixed paraffin embedded normal and pathological tissues.	Polysaccharides	103-110	LOC100508689	Homo sapiens	147-152
11073082-3	2000	The Mabs reacted with bovine alpha1AGP on immunoblot analysis, but not with alpha1AGP digested with N-glycosidase, suggesting that an epitope recognized by these Mabs may be associated with a glycan side chain of bovine alpha1AGP.	Polysaccharides	192-198	alpha-1-acid glycoprotein	Bos taurus	29-38
10992488-2	2000	In this study, the antigenic cross-reactivity of myosin and N-acetyl-glucosamine (GlcNAc), the dominant epitope of Group A streptococcal polysaccharide, was examined.	Polysaccharides	137-151	myosin heavy chain 14	Homo sapiens	49-55
10972975-6	2000	Horseradish peroxidase (HRP)-lectin staining showed that the 7721 cells transfected with nm23-H1 or the A549 cells transfected with p16 displayed a decreased intensity with HRP-leucoagglutinating phytohemagglutinin and increased intensity with HRP-concanavalin A, indicating the decline of beta1,6 N-acetylglucosamine branching structure on the asparagine-linked glycans of cell-surface and intracellular glycoproteins.	Polysaccharides	363-370	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	89-96
10867010-1	2000	Demonstration of concerted contributions of glycan sialylation and subunit assembly to the pharmacokinetic behavior of bovine acetylcholinesterase.	Polysaccharides	44-50	acetylcholinesterase	Bos taurus	126-146
10972975-6	2000	Horseradish peroxidase (HRP)-lectin staining showed that the 7721 cells transfected with nm23-H1 or the A549 cells transfected with p16 displayed a decreased intensity with HRP-leucoagglutinating phytohemagglutinin and increased intensity with HRP-concanavalin A, indicating the decline of beta1,6 N-acetylglucosamine branching structure on the asparagine-linked glycans of cell-surface and intracellular glycoproteins.	Polysaccharides	363-370	cyclin dependent kinase inhibitor 2A	Homo sapiens	132-135
10948122-1	2000	Epidemiologic and experimental data provide evidence that a critical level of serum immunoglobulin G (IgG) antibodies to the surface polysaccharide of Vibrio cholerae O1 (lipopolysaccharide) and of Vibrio cholerae O139 (capsular polysaccharide [CPS]) is associated with immunity to the homologous pathogen.	Polysaccharides	133-147	immunoglobulin heavy variable V1-62	Mus musculus	102-105
10913359-0	2000	Accessibility of the high-mannose glycans of glycoprotein gp120 from human immunodeficiency virus type 1 probed by in vitro interaction with mannose-binding lectins.	Polysaccharides	34-41	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	58-63
10987135-3	2000	When mice were injected with fractions, CZ-1 and CZ-1-III, at the dose of 100.0 mg/kg, 91.6% and 97.1% of tumor growth were inhibited, respectively, indicating that the cytotoxic effect of polysaccharide on sarcoma 180 cells increases upon increasing the amount of polysaccharide administered.	Polysaccharides	189-203	immunoglobulin kappa variable 1-115	Mus musculus	40-57
10987135-3	2000	When mice were injected with fractions, CZ-1 and CZ-1-III, at the dose of 100.0 mg/kg, 91.6% and 97.1% of tumor growth were inhibited, respectively, indicating that the cytotoxic effect of polysaccharide on sarcoma 180 cells increases upon increasing the amount of polysaccharide administered.	Polysaccharides	265-279	immunoglobulin kappa variable 1-115	Mus musculus	40-57
10963781-2	2000	The main component of normal serum transferrin contains two biantennary glycans, each consisting of 2 mol of sialic acid (Tetrasialo transferrin).	Polysaccharides	72-79	transferrin	Homo sapiens	35-46
10913359-5	2000	These results demonstrate that mannose-specific plant lectins are powerful tools to study the accessibility and elucidate the function of the gp120 glycans in the recognition and infection of the host cells by HIV-1.	Polysaccharides	148-155	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	142-147
10971113-2	2000	Gly m Bd 28K, a soybean allergen, was a glycoprotein with glycan moieties, which are supposed to be the Man(3)GlcNAc(2) backbone with the beta1--&gt;2 xylose and alpha1--&gt;3 fucose branches.	Polysaccharides	58-64	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	138-143
10934164-5	2000	PrP(M) contained an aberrant glycan at residue 197 and generated an increased quantity of truncated fragments.	Polysaccharides	29-35	caspase recruitment domain family member 14	Homo sapiens	0-3
10903509-0	2000	Recombinant glycodelin carrying the same type of glycan structures as contraceptive glycodelin-A can be produced in human kidney 293 cells but not in chinese hamster ovary cells.	Polysaccharides	49-55	progestagen associated endometrial protein	Homo sapiens	12-22
10971113-2	2000	Gly m Bd 28K, a soybean allergen, was a glycoprotein with glycan moieties, which are supposed to be the Man(3)GlcNAc(2) backbone with the beta1--&gt;2 xylose and alpha1--&gt;3 fucose branches.	Polysaccharides	58-64	adrenoceptor alpha 1D	Homo sapiens	162-168
10971113-3	2000	The purpose of the present study was to examine the IgE-binding ability of the glycan moiety of Gly m Bd 28K in the binding reaction with patients" sera.	Polysaccharides	79-85	immunoglobulin heavy constant epsilon	Homo sapiens	52-55
10971113-7	2000	The binding of patients" IgE antibodies with their glycan moiety was examined by an immunostaining technique using the glycopeptide and its deglycosylated peptide derived from Gly m Bd 28K.	Polysaccharides	51-57	immunoglobulin heavy constant epsilon	Homo sapiens	25-28
10971113-11	2000	CONCLUSIONS: The specific IgE antibodies recognizing the N-linked glycan moieties of Gly m Bd 28K and other glycoproteins with homologous glycan moieties occur in the sera of soybean-sensitive patients.	Polysaccharides	66-72	immunoglobulin heavy constant epsilon	Homo sapiens	26-29
10987560-10	2000	The limited changes seen in the monosaccharide compositions, glycosidic linkage patterns and quantities of non-cellulosic polysaccharides support the view that the RSW1, RSW2 and RSW3 genes are specifically involved in cellulose synthesis.	Polysaccharides	122-137	cellulose synthase 1	Arabidopsis thaliana	164-168
10959738-1	2000	BACKGROUND: We compared the antibody response to Haemophilus influenzae type b capsular polysaccharide (PRP) after three doses of a diphtheria toxoid, tetanus toxoid and acellular pertussis vaccine (DTaP) combined with a PRP-tetanus conjugate (PRP-T) in infants randomized to receive oral polio vaccine (OPV) or inactivated polio vaccine (IPV).	Polysaccharides	88-102	prion protein	Homo sapiens	104-107
10987560-10	2000	The limited changes seen in the monosaccharide compositions, glycosidic linkage patterns and quantities of non-cellulosic polysaccharides support the view that the RSW1, RSW2 and RSW3 genes are specifically involved in cellulose synthesis.	Polysaccharides	122-137	Glycosyl hydrolases family 31 protein	Arabidopsis thaliana	179-183
10891067-1	2000	Endo-beta-N-acetylglucosaminidase F(3) cleaves the beta(1-4) link between the core GlcNAc"s of asparagine-linked oligosaccharides, with specificity for biantennary and triantennary complex glycans.	Polysaccharides	189-196	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	51-59
10913821-3	2000	We report the occurrence of sialic acid in alpha 2,3- and alpha 2,6-linkage to galactose in bovine UPIII glycans as evidenced by the sensitivity of UPIII to both Vibrio cholera and Newcastle disease virus neuraminidase and by the colocalization of UPIII antigen and material detected by lectins of Sambucus nigra and Maackia amurensis on the luminal face of the bladder.	Polysaccharides	105-112	uroplakin 3A	Bos taurus	99-104
10913821-6	2000	The putative role of UPIII sialylated glycans in enhancing the uropathogenicity of E. coli expressing type S adhesins is discussed.	Polysaccharides	38-45	uroplakin 3A	Bos taurus	21-26
10913832-0	2000	Structural analysis of trisialylated biantennary glycans isolated from mouse serum transferrin.	Polysaccharides	49-56	transferrin	Homo sapiens	83-94
10913832-8	2000	The structure of the major glycan found in variant mTf-IV contained an additional Neu5Gc and possessed the following new type of linkage: Neu5Gc(alpha 2-3)Gal(beta 1-3)[Neu5Gc(alpha 2-6)]GlcNAc(beta 1-2 )Man(alpha 1-3).	Polysaccharides	27-33	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	159-165
10913832-8	2000	The structure of the major glycan found in variant mTf-IV contained an additional Neu5Gc and possessed the following new type of linkage: Neu5Gc(alpha 2-3)Gal(beta 1-3)[Neu5Gc(alpha 2-6)]GlcNAc(beta 1-2 )Man(alpha 1-3).	Polysaccharides	27-33	immunoglobulin binding protein 1	Homo sapiens	176-185
10913832-8	2000	The structure of the major glycan found in variant mTf-IV contained an additional Neu5Gc and possessed the following new type of linkage: Neu5Gc(alpha 2-3)Gal(beta 1-3)[Neu5Gc(alpha 2-6)]GlcNAc(beta 1-2 )Man(alpha 1-3).	Polysaccharides	27-33	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	194-202
10913832-8	2000	The structure of the major glycan found in variant mTf-IV contained an additional Neu5Gc and possessed the following new type of linkage: Neu5Gc(alpha 2-3)Gal(beta 1-3)[Neu5Gc(alpha 2-6)]GlcNAc(beta 1-2 )Man(alpha 1-3).	Polysaccharides	27-33	adrenoceptor alpha 1D	Homo sapiens	208-215
10770931-6	2000	By contrast, the O-glycans linked to uromodulin include unusual core 2 type glycans terminated with one, two, or three sialyl Lewis(x) sequences.	Polysaccharides	19-26	uromodulin	Homo sapiens	37-47
10908805-1	2000	The major cationic peanut (Arachis hypogaea) peroxidase, secreted into the extracellular space, is a glycoprotein with three N-linked glycans (polysaccharides) which are connected to the peptide backbone at Asn-60, Asn-144 and Asn-185.	Polysaccharides	143-158	peroxidase N1-like	Nicotiana tabacum	45-55
10908805-5	2000	Cationic peanut peroxidase isolated from the above transgenic tobacco had the identical number of complex glycans, attached at the same glycosylation sites as on cationic peanut peroxidase isolated from peanut suspension culture.	Polysaccharides	106-113	peroxidase N1-like	Nicotiana tabacum	16-26
10908805-6	2000	Monosaccharide components of these glycans are N-acetylglucosamine (GlcNAc), mannose (Man), fucose (Fuc), xylose (Xyl) and galactose (Gal), the same sugars as found in native cationic peanut peroxidase.	Polysaccharides	35-42	peroxidase N1-like	Nicotiana tabacum	191-201
10881171-5	2000	In response to repetitive polysaccharide antigens (T-independent type II (TI-II)) Pyk-2-deficient mice displayed marked suppression of IgM, IgG3 and IgG2a production.	Polysaccharides	26-40	PTK2 protein tyrosine kinase 2 beta	Mus musculus	82-87
11710108-2	2000	Using analogies from nature, we investigated the possibility that tyrosinase-catalyzed reactions of 3,4-dihydroxyphenethylamine (dopamine) could confer water-resistant adhesive properties to semidilute solutions of the polysaccharide chitosan.	Polysaccharides	219-233	tyrosinase	Homo sapiens	66-76
10857602-1	2000	Sequential stages of mass spectrometry (MSn) have the potential to provide a great deal of structural information in glycan analysis.	Polysaccharides	117-123	moesin	Homo sapiens	40-43
10889259-8	2000	GntI-expression constructs were tested for the ability to relieve the GnTI block in protoplasts of the Arabidopsis cgl mutant and used to obtain transgenic potato and tobacco plants that display a substantial reduction of complex glycan patterns.	Polysaccharides	230-236	alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	Arabidopsis thaliana	0-4
10838166-7	2000	These results suggest that OSF is a highly sulfated unique polysaccharide that can promote the binding of bFGF to the heparan sulfate molecules required for binding to the high affinity receptors with tyrosine kinase activity.	Polysaccharides	59-73	fibroblast growth factor 2	Homo sapiens	106-110
10811884-1	2000	The beta-1,6-N-acetylglucosaminyltransferase (beta1,6GnT) gene family encodes enzymes playing crucial roles in glycan synthesis.	Polysaccharides	111-117	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	4-44
10814696-1	2000	Despite numerous studies on arylsulfatase A, the structure of its glycans is not well understood.	Polysaccharides	66-73	arylsulfatase A	Homo sapiens	28-43
10833030-5	2000	The other glycoproteins contained mainly larger, complex glycans with up to five antennae, many of which had earlier been associated with ovalbumin.	Polysaccharides	57-64	ovalbumin (SERPINB14)	Gallus gallus	138-147
10896248-2	2000	Recently, it was reported that thrombin cleaves full-length recombinant human Tpo (rhTpo) sequentially at two sites, Arg(195) within the glycan domain followed by Arg(117) within the cytokine domain, and that these cleavages modulate Tpo activity in vitro.	Polysaccharides	137-143	coagulation factor II, thrombin	Homo sapiens	31-39
10896248-2	2000	Recently, it was reported that thrombin cleaves full-length recombinant human Tpo (rhTpo) sequentially at two sites, Arg(195) within the glycan domain followed by Arg(117) within the cytokine domain, and that these cleavages modulate Tpo activity in vitro.	Polysaccharides	137-143	thrombopoietin	Homo sapiens	78-81
10896248-5	2000	In contrast, plasmin cleaves Tpo sequentially at two specific sites (Arg(205) within the glycan domain followed by Lys(52) within the cytokine domain), and is associated with a marked decrease in Tpo activity.	Polysaccharides	89-95	plasminogen	Homo sapiens	13-20
10896248-5	2000	In contrast, plasmin cleaves Tpo sequentially at two specific sites (Arg(205) within the glycan domain followed by Lys(52) within the cytokine domain), and is associated with a marked decrease in Tpo activity.	Polysaccharides	89-95	thrombopoietin	Homo sapiens	29-32
10775792-0	2000	Differing serologic responses to an haemophilus influenzae type b polysaccharide-neisseria meningitidis outer membrane protein conjugate (PRP-OMPC) vaccine in australian aboriginal and caucasian infants - implications for disease epidemiology.	Polysaccharides	66-80	prion protein	Homo sapiens	138-141
11294506-3	2000	Here we report a sensitive mapping strategy for profiling and analysing the N-glycosylation of gp160, based on chemical release of glycans, fluorescent labelling and HPLC analysis.	Polysaccharides	131-138	glutamyl aminopeptidase	Homo sapiens	95-100
10894360-0	2000	Upregulation of interleukin-10 and inhibition of alloantigen responses by transferrin and transferrin-derived glycans.	Polysaccharides	110-117	interleukin 10	Homo sapiens	16-30
10894360-0	2000	Upregulation of interleukin-10 and inhibition of alloantigen responses by transferrin and transferrin-derived glycans.	Polysaccharides	110-117	transferrin	Homo sapiens	90-101
10811884-1	2000	The beta-1,6-N-acetylglucosaminyltransferase (beta1,6GnT) gene family encodes enzymes playing crucial roles in glycan synthesis.	Polysaccharides	111-117	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	46-56
10845701-6	2000	The BSSL glycans were characterized through monosaccharide analysis, high-pH anion-exchange chromatography, matrix-assisted laser desorption-ionization mass spectrometry, and ELISA.	Polysaccharides	9-16	carboxyl ester lipase	Homo sapiens	4-8
10794707-4	2000	Protein-linked monoglucosylated glycans, formed by glucosidase I- and glucosidase II-dependent partial deglucosylation of the oligosaccharides transferred from dolichol diphosphate derivatives in N-glycosylation (Glc(3)Man(9)GlcNAc(2)), mediate glycoprotein recognition by two ER-resident lectins, membrane-bound calnexin (CNX) and its soluble homologue, calreticulin (CRT).	Polysaccharides	32-39	mannosyl-oligosaccharide glucosidase	Homo sapiens	51-84
10794707-4	2000	Protein-linked monoglucosylated glycans, formed by glucosidase I- and glucosidase II-dependent partial deglucosylation of the oligosaccharides transferred from dolichol diphosphate derivatives in N-glycosylation (Glc(3)Man(9)GlcNAc(2)), mediate glycoprotein recognition by two ER-resident lectins, membrane-bound calnexin (CNX) and its soluble homologue, calreticulin (CRT).	Polysaccharides	32-39	calnexin	Homo sapiens	313-321
10794707-4	2000	Protein-linked monoglucosylated glycans, formed by glucosidase I- and glucosidase II-dependent partial deglucosylation of the oligosaccharides transferred from dolichol diphosphate derivatives in N-glycosylation (Glc(3)Man(9)GlcNAc(2)), mediate glycoprotein recognition by two ER-resident lectins, membrane-bound calnexin (CNX) and its soluble homologue, calreticulin (CRT).	Polysaccharides	32-39	calnexin	Homo sapiens	323-326
10794707-4	2000	Protein-linked monoglucosylated glycans, formed by glucosidase I- and glucosidase II-dependent partial deglucosylation of the oligosaccharides transferred from dolichol diphosphate derivatives in N-glycosylation (Glc(3)Man(9)GlcNAc(2)), mediate glycoprotein recognition by two ER-resident lectins, membrane-bound calnexin (CNX) and its soluble homologue, calreticulin (CRT).	Polysaccharides	32-39	calreticulin	Homo sapiens	355-367
10794707-6	2000	Further deglucosylation of glycans by glucosidase II, and perhaps also by a change in CNX/CRT and/or in the substrate glycoprotein conformation, liberates the glycoproteins from their CNX/CRT anchors.	Polysaccharides	27-34	calnexin	Homo sapiens	86-89
10794707-6	2000	Further deglucosylation of glycans by glucosidase II, and perhaps also by a change in CNX/CRT and/or in the substrate glycoprotein conformation, liberates the glycoproteins from their CNX/CRT anchors.	Polysaccharides	27-34	calnexin	Homo sapiens	184-187
10794707-7	2000	Glycans may be then reglucosylated by the UDP-Glc:glycoprotein glucosyltransferase (GT), and thus be recognized again by CNX/CRT, but only when linked to not yet properly folded protein moieties, as this enzyme behaves as a sensor of glycoprotein conformation.	Polysaccharides	0-7	calnexin	Homo sapiens	121-124
10794707-9	2000	The interaction between CNX/CRT and a monoglucosylated glycan is one of the alternative mechanisms by which cells retain not yet properly folded glycoproteins in the ER; in addition, it enhances folding efficiency by preventing protein aggregation and thus allowing intervention of classical chaperones and other folding-assisting proteins.	Polysaccharides	55-61	calnexin	Homo sapiens	24-27
10777581-6	2000	Conversely, transfection of cells from the 14CWT line expressing very low levels of E48 with E48 cDNA caused an up-regulated expression of FX and of the two fucosylated glycans in the 14C-CMV16 transfectants.	Polysaccharides	169-176	lymphocyte antigen 6 family member D	Homo sapiens	84-87
10764840-3	2000	The structure of the glycan chains of this rHuEpo slightly differ of those of the urinary human Epo (uHuEpo), considered as the natural Epo molecule.	Polysaccharides	21-27	erythropoietin	Homo sapiens	46-49
10864148-0	2000	Sedum telephium L. polysaccharide content affects MRC5 cell adhesion to laminin and fibronectin.	Polysaccharides	19-33	fibronectin 1	Homo sapiens	84-95
10819991-0	2000	Tyrosinase and glycoprotein folding: roles of chaperones that recognize glycans.	Polysaccharides	72-79	tyrosinase	Homo sapiens	0-10
10793139-6	2000	Abolition of Gpi11p or Pig-Fp function in GPI11 disruptants blocks GPI anchoring and formation of complete GPI precursors and leads to accumulation of two GPIs whose glycan head groups contain four mannoses but differ in the positioning and number of side chains, probably EthN-Ps.	Polysaccharides	166-172	mannose-ethanolamine phosphotransferase GPI11	Saccharomyces cerevisiae S288C	13-19
10793139-6	2000	Abolition of Gpi11p or Pig-Fp function in GPI11 disruptants blocks GPI anchoring and formation of complete GPI precursors and leads to accumulation of two GPIs whose glycan head groups contain four mannoses but differ in the positioning and number of side chains, probably EthN-Ps.	Polysaccharides	166-172	phosphatidylinositol glycan anchor biosynthesis class F	Sus scrofa	23-29
10793139-6	2000	Abolition of Gpi11p or Pig-Fp function in GPI11 disruptants blocks GPI anchoring and formation of complete GPI precursors and leads to accumulation of two GPIs whose glycan head groups contain four mannoses but differ in the positioning and number of side chains, probably EthN-Ps.	Polysaccharides	166-172	mannose-ethanolamine phosphotransferase GPI11	Saccharomyces cerevisiae S288C	42-47
10777581-6	2000	Conversely, transfection of cells from the 14CWT line expressing very low levels of E48 with E48 cDNA caused an up-regulated expression of FX and of the two fucosylated glycans in the 14C-CMV16 transfectants.	Polysaccharides	169-176	lymphocyte antigen 6 family member D	Homo sapiens	93-96
10727403-5	2000	Similar incubations performed in the presence of (3)H(2)O resulted in progressive labelling at C-5 of the target hexuronic acid units of either substrate polysaccharide.	Polysaccharides	154-168	complement C5	Bos taurus	95-98
10753952-1	2000	Heparin cofactor II (HCII) is a plasma serine protease inhibitor whose ability to inhibit alpha-thrombin is accelerated by a variety of sulfated polysaccharides in addition to heparin and dermatan sulfate.	Polysaccharides	145-160	serpin family D member 1	Homo sapiens	0-19
10753952-1	2000	Heparin cofactor II (HCII) is a plasma serine protease inhibitor whose ability to inhibit alpha-thrombin is accelerated by a variety of sulfated polysaccharides in addition to heparin and dermatan sulfate.	Polysaccharides	145-160	serpin family D member 1	Homo sapiens	21-25
10753952-1	2000	Heparin cofactor II (HCII) is a plasma serine protease inhibitor whose ability to inhibit alpha-thrombin is accelerated by a variety of sulfated polysaccharides in addition to heparin and dermatan sulfate.	Polysaccharides	145-160	coagulation factor II, thrombin	Homo sapiens	96-104
10753952-2	2000	Previous investigations have indicated that calcium spirulan (Ca-SP), a novel sulfated polysaccharide, enhanced the rate of inhibition of alpha-thrombin by HCII.	Polysaccharides	87-101	coagulation factor II, thrombin	Homo sapiens	144-152
10753952-2	2000	Previous investigations have indicated that calcium spirulan (Ca-SP), a novel sulfated polysaccharide, enhanced the rate of inhibition of alpha-thrombin by HCII.	Polysaccharides	87-101	serpin family D member 1	Homo sapiens	156-160
10764645-5	2000	Direct interaction with calnexin and calreticulin without prior interaction with BiP occurred if glycans were present within about 50 residues of the protein"s NH2-terminus.	Polysaccharides	97-104	calnexin	Homo sapiens	24-32
10764645-5	2000	Direct interaction with calnexin and calreticulin without prior interaction with BiP occurred if glycans were present within about 50 residues of the protein"s NH2-terminus.	Polysaccharides	97-104	calreticulin	Homo sapiens	37-49
10744664-1	2000	Using sequential digestion with the glycyl-glycine endopeptidase lysostaphin followed by the pneumococcal N-acetylmuramyl-L-alanine amidase (amidase), the glycan strands of the peptidoglycan of Staphylococcus aureus were purified and analyzed by a combination of reverse-phase-high pressure liquid chromatography (HPLC) and mass spectrometry.	Polysaccharides	155-161	AT695_RS13185	Staphylococcus aureus	132-139
10763242-1	2000	A 1-mm microbore hydrophilic interaction column has been used for the separation of 2-aminoacridone (2-AMAC)-derivatized glycan mixtures, released from naturally occurring and recombinant proteins.	Polysaccharides	121-127	solute carrier family 35 member G5	Homo sapiens	103-107
10763242-2	2000	Primary structure identification of the 2-AMAC glycan derivatives was carried out by HPLC using fluorescence and mass spectrometric detection.	Polysaccharides	47-53	solute carrier family 35 member G5	Homo sapiens	42-46
10763242-3	2000	In some cases, enzymatic digestion of the 2-AMAC glycans was applied to confirm glycan structure.	Polysaccharides	49-55	solute carrier family 35 member G5	Homo sapiens	44-48
10727405-1	2000	Tetranectin is a homotrimeric plasma and extracellular-matrix protein that binds plasminogen and complex sulphated polysaccharides including heparin.	Polysaccharides	115-130	C-type lectin domain family 3 member B	Homo sapiens	0-11
10713140-5	2000	Analysis of the folding pathway and activity of 15 tyrosinase mutants lacking one or more of the occupied N-glycosylation sites shows that glycans at any two N-glycosylation sites are sufficient to interact with calnexin and give partial activity, but a specific pair of sites (Asn(86) and Asn(371)) is required for full activity.	Polysaccharides	139-146	tyrosinase	Homo sapiens	51-61
10722601-4	2000	Transposon-derived type III strain COH1-13, which lacks capsular polysaccharide, and strain COH1-11 with capsular polysaccharide lacking terminal sialic acid demonstrated increased neutrophil binding, suggesting that capsular polysaccharide masks an underlying binding site.	Polysaccharides	114-128	vacuolar protein sorting 13 homolog B	Homo sapiens	92-96
10715210-6	2000	The PPGs are further modified with a GPI anchor which differs from all other eukaryotic GPI anchors so far characterized in containing a glycan core with the structure, Gal(1)Man(2)GlcN-myo-inositol, and in being heterogeneously modified with chains of alpha-galactose.	Polysaccharides	137-143	galectin 1	Homo sapiens	169-174
10722601-4	2000	Transposon-derived type III strain COH1-13, which lacks capsular polysaccharide, and strain COH1-11 with capsular polysaccharide lacking terminal sialic acid demonstrated increased neutrophil binding, suggesting that capsular polysaccharide masks an underlying binding site.	Polysaccharides	114-128	vacuolar protein sorting 13 homolog B	Homo sapiens	92-96
10791783-0	2000	Presence of a glycan at a potential N-glycosylation site, Asn-281, of bovine lactoferrin.	Polysaccharides	14-20	lactotransferrin	Bos taurus	77-88
10791783-5	2000	The glycan linked to Asn-281 of bovine lactoferrin-a was found to consist of fucose, galactose, and N-acetylgalactosamine in addition to mannose and N-acetylglucosamine.	Polysaccharides	4-10	lactotransferrin	Bos taurus	39-50
10715125-0	2000	The glycan domain of thrombopoietin enhances its secretion.	Polysaccharides	4-10	thrombopoietin	Homo sapiens	21-35
10713140-5	2000	Analysis of the folding pathway and activity of 15 tyrosinase mutants lacking one or more of the occupied N-glycosylation sites shows that glycans at any two N-glycosylation sites are sufficient to interact with calnexin and give partial activity, but a specific pair of sites (Asn(86) and Asn(371)) is required for full activity.	Polysaccharides	139-146	calnexin	Homo sapiens	212-220
10691991-8	2000	Both glycans are xylose containing biantennary complex types that share the common core structural unit, Man1--&gt;6(Man1--&gt;3) (Xyl1--&gt;2)Man1--&gt;4GlcNAc1--&gt;4(Fuc1--&gt;3)GlcNAc for the major form, with an additional N-acetylglucosamine residue being linked, in the minor form, to one of the terminal mannose units of the core structure.	Polysaccharides	5-12	LEM domain containing 3	Homo sapiens	105-109
10818267-7	2000	The sensitivity to sulfated polysaccharides indicated an involvement of oligobasic epitopes of hIFN-gamma in the binding.	Polysaccharides	28-43	interferon gamma	Homo sapiens	95-105
10818267-11	2000	Also, acidic polysaccharides such as heparin were much more efficacious in the inhibition of hIFN-gamma binding to hemolymph relative to protocerebral particulates.	Polysaccharides	13-28	interferon gamma	Homo sapiens	93-103
10702238-2	2000	Two genes coding for thymidine diphosphate (dTDP)-6-deoxy-L-lyxo-4-hexulose reductases were identified in the gene cluster required for biosynthesis of serotype c-specific polysaccharide.	Polysaccharides	172-186	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	44-48
10691991-8	2000	Both glycans are xylose containing biantennary complex types that share the common core structural unit, Man1--&gt;6(Man1--&gt;3) (Xyl1--&gt;2)Man1--&gt;4GlcNAc1--&gt;4(Fuc1--&gt;3)GlcNAc for the major form, with an additional N-acetylglucosamine residue being linked, in the minor form, to one of the terminal mannose units of the core structure.	Polysaccharides	5-12	LEM domain containing 3	Homo sapiens	117-121
10691991-8	2000	Both glycans are xylose containing biantennary complex types that share the common core structural unit, Man1--&gt;6(Man1--&gt;3) (Xyl1--&gt;2)Man1--&gt;4GlcNAc1--&gt;4(Fuc1--&gt;3)GlcNAc for the major form, with an additional N-acetylglucosamine residue being linked, in the minor form, to one of the terminal mannose units of the core structure.	Polysaccharides	5-12	LEM domain containing 3	Homo sapiens	117-121
10700233-2	2000	Amounts of MGAT5 glycan products are commonly increased in malignancies, and correlate with disease progression.	Polysaccharides	17-23	mannoside acetylglucosaminyltransferase 5	Mus musculus	11-16
10678959-7	2000	The polysaccharide-specific antibody response to 19F-CRM(197) alone was predominantly of the immunoglobulin G1 (IgG1) and IgM isotypes, but addition of CpG ODN markedly increased geometric mean titers of total anti-19F antibody (23-fold), anti-19F IgG2a (26-fold), and anti-19F IgG3 (&gt;246-fold).	Polysaccharides	4-18	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	278-282
10678959-8	2000	The polysaccharide-specific antibody response to 6B-CRM(197) alone consisted only of IgM, but addition of CpG ODN induced high titers of anti-6B IgG1 (&gt;78-fold increase), anti-6B IgG2a (&gt;54-fold increase), and anti-6B IgG3 (&gt;3,162-fold increase).	Polysaccharides	4-18	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	224-228
10700233-6	2000	Furthermore, Mgat5 glycan products stimulated membrane ruffling and phosphatidylinositol 3 kinase-protein kinase B activation, fueling a positive feedback loop that amplified oncogene signaling and tumor growth in vivo.	Polysaccharides	19-25	mannoside acetylglucosaminyltransferase 5	Mus musculus	13-18
10640353-1	2000	This communication describes the use of two-dimensional relayed (TOCSY)-ROESY experiments for the rapid and selective identification of alpha/beta1,2-glycosidic linkages in polysaccharides.	Polysaccharides	173-188	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	136-149
10737203-0	2000	Effect of a polysaccharide (TAP) from the fruiting bodies of Tremella aurantia on glucose metabolism in mouse liver.	Polysaccharides	12-26	lymphocyte antigen 6 complex, locus A	Mus musculus	28-31
10737203-1	2000	An acidic polysaccharide (TAP) obtained from the fruiting bodies of Tremella aurantia significantly increased the activities of glucokinase, hexokinase, and glucose-6-phosphate dehydrogenase, and decreased the activity of glucose-6-phosphatase in normal and diabetic mouse liver after intraperitoneal administration, while the glycogen content in the liver was reduced.	Polysaccharides	10-24	lymphocyte antigen 6 complex, locus A	Mus musculus	26-29
10950153-10	2000	We have developed a novel formula of hydrophobized polysaccharide nanoparticles which can deliver a HER2 oncoprotein containing an epitope peptide to the MHC class I pathway.	Polysaccharides	51-65	erb-b2 receptor tyrosine kinase 2	Mus musculus	100-104
10877533-6	2000	The molecular weights of the recombinant chymase and chymase purified from human vascular tissues were 26 and 30 kDa, respectively, and the 4 kDa difference was thought to be due to the presence or absence of glycan.	Polysaccharides	209-215	chymase 1	Homo sapiens	41-48
10639411-5	2000	In mice immunized with whole bacteria, MR-1 treatment reduced antibody responses to capsular polysaccharides but not cell wall polysaccharides.	Polysaccharides	93-108	major histocompatibility complex, class I-related	Mus musculus	39-43
10639411-6	2000	MR-1 did not suppress antibody responses to isolated capsular polysaccharides but did reduce the production of antibody to a capsular polysaccharide-protein conjugate, indicating that when presented in the context of whole bacteria, the humoral response to capsular polysaccharides is partially T-cell dependent.	Polysaccharides	266-281	major histocompatibility complex, class I-related	Mus musculus	0-4
10721716-1	2000	Glycogenin-2 is one of two self-glucosylating proteins involved in the initiation phase of the synthesis of the storage polysaccharide glycogen.	Polysaccharides	120-134	glycogenin 2	Homo sapiens	0-12
11065057-4	2000	The component in beer responsible for the effect on prolactin secretion is not the alcohol content but apparently a polysaccharide from barley, which explains that the effect on prolactin can also be induced by non-alcoholic beer.	Polysaccharides	116-130	prolactin	Homo sapiens	52-61
11065057-4	2000	The component in beer responsible for the effect on prolactin secretion is not the alcohol content but apparently a polysaccharide from barley, which explains that the effect on prolactin can also be induced by non-alcoholic beer.	Polysaccharides	116-130	prolactin	Homo sapiens	178-187
11018130-4	2000	Glycans that are discussed include the Nod factors, the extracellular polysaccharides, the lipopolysaccharides, the K-antigens, and the cyclic glucans.	Polysaccharides	0-7	atrophin 1	Homo sapiens	39-42
10950153-11	2000	We designed a simple protein delivery system: cholesteryl group-bearing polysaccharides, mannan or pullulan (CHM or CHP, respectively), complexed with the truncated HER2 protein containing the 147 N-terminal amino acids.	Polysaccharides	72-87	erb-b2 receptor tyrosine kinase 2	Mus musculus	165-169
10632704-5	2000	The properties of midkine binding to sulfatide and to CHO-3-SO4 differed in their sensitivity to inhibition by anionic polysaccharides, salt concentration and unlabeled midkine.	Polysaccharides	119-134	midkine	Mus musculus	18-25
11448066-0	2000	Protein-bound polysaccharide PSK inhibits tumor invasiveness by down-regulation of TGF-beta1 and MMPs.	Polysaccharides	14-28	transforming growth factor beta 1	Homo sapiens	83-92
11448066-0	2000	Protein-bound polysaccharide PSK inhibits tumor invasiveness by down-regulation of TGF-beta1 and MMPs.	Polysaccharides	14-28	matrix metallopeptidase 2	Homo sapiens	97-101
11521064-9	2000	These findings showed that cellular activation by Gram-positive cell wall components was mediated by TLR2, but not TLR4, and indicated that the glycan backbone of peptidoglycan is critical for TLR2-mediated NF-kappaB activation.	Polysaccharides	144-150	Tlr2	Cricetulus griseus	101-105
10570220-10	2000	The present data therefore indicate that, in the same manner as HIV-1 Env, SDF-1alpha can interact with GAGs and glycans at the cell surface.	Polysaccharides	113-120	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	70-73
16232825-3	2000	Three polysaccharides (IV-1, IV-2, and IV-3) composed mainly of glucose showed marked antitumor activities against Sarcoma 180 and their average molecular weights were 305 kDa, 130 kDa and 14 kDa, respectively.	Polysaccharides	6-21	cytochrome c oxidase subunit 4I1	Mus musculus	23-27
11521064-9	2000	These findings showed that cellular activation by Gram-positive cell wall components was mediated by TLR2, but not TLR4, and indicated that the glycan backbone of peptidoglycan is critical for TLR2-mediated NF-kappaB activation.	Polysaccharides	144-150	Tlr2	Cricetulus griseus	193-197
10611478-2	1999	L1 has been shown to interact with NCAM, possibly through NCAM binding to oligomannosidic glycans present in L1.	Polysaccharides	90-97	neural cell adhesion molecule 1	Homo sapiens	35-39
10656421-6	2000	The results indicated a glycan structure comprising a Man alpha1-6(Xyl beta1-2)Man beta1-4GlcNAc beta1-4(Fuc alpha1-3)GlcNAc beta core but with an additional Man alpha1-3 appendage linked to Man3.	Polysaccharides	24-30	adrenoceptor alpha 1D	Homo sapiens	58-66
10656421-6	2000	The results indicated a glycan structure comprising a Man alpha1-6(Xyl beta1-2)Man beta1-4GlcNAc beta1-4(Fuc alpha1-3)GlcNAc beta core but with an additional Man alpha1-3 appendage linked to Man3.	Polysaccharides	24-30	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	71-78
10656421-6	2000	The results indicated a glycan structure comprising a Man alpha1-6(Xyl beta1-2)Man beta1-4GlcNAc beta1-4(Fuc alpha1-3)GlcNAc beta core but with an additional Man alpha1-3 appendage linked to Man3.	Polysaccharides	24-30	adrenoceptor alpha 1D	Homo sapiens	109-117
10656421-6	2000	The results indicated a glycan structure comprising a Man alpha1-6(Xyl beta1-2)Man beta1-4GlcNAc beta1-4(Fuc alpha1-3)GlcNAc beta core but with an additional Man alpha1-3 appendage linked to Man3.	Polysaccharides	24-30	adrenoceptor alpha 1D	Homo sapiens	162-170
10737549-8	2000	Among polysaccharides tested, only the highly viscous alginates could affect intestinal absorption of glucose and insulin response.	Polysaccharides	6-21	insulin	Sus scrofa	114-121
10611478-2	1999	L1 has been shown to interact with NCAM, possibly through NCAM binding to oligomannosidic glycans present in L1.	Polysaccharides	90-97	neural cell adhesion molecule 1	Homo sapiens	58-62
10584881-0	1999	Glycan composition of serum alpha-fetoprotein in patients with hepatocellular carcinoma and non-seminomatous germ cell tumour.	Polysaccharides	0-6	alpha fetoprotein	Homo sapiens	28-45
10585852-8	1999	In the presence of alpha-glucosidases inhibitors, the maturation of tyrosinase N-glycans is completely inhibited, whereas TRP-1 is still able to acquire some complex glycans, indicating that endomannosidase acts preferentially on the later glycoprotein.	Polysaccharides	81-88	tyrosinase	Mus musculus	68-78
10585852-8	1999	In the presence of alpha-glucosidases inhibitors, the maturation of tyrosinase N-glycans is completely inhibited, whereas TRP-1 is still able to acquire some complex glycans, indicating that endomannosidase acts preferentially on the later glycoprotein.	Polysaccharides	81-88	mannosidase, endo-alpha	Mus musculus	191-206
10580135-5	1999	In addition to the well-understood role of mannose 6-phosphate receptor in lysosomal protein sorting, the vesicular integral protein of 36 kDa (VIP36) functions as a sorting receptor by recognizing high-mannose type glycans containing alpha1--&gt;2Man residues for transport from Golgi to the cell surface in polarized epithelial cells.	Polysaccharides	216-223	lectin, mannose binding 2	Homo sapiens	106-142
10580135-5	1999	In addition to the well-understood role of mannose 6-phosphate receptor in lysosomal protein sorting, the vesicular integral protein of 36 kDa (VIP36) functions as a sorting receptor by recognizing high-mannose type glycans containing alpha1--&gt;2Man residues for transport from Golgi to the cell surface in polarized epithelial cells.	Polysaccharides	216-223	lectin, mannose binding 2	Homo sapiens	144-149
10581158-5	1999	Among the polysaccharides, heparin, chondroitin sulphates A, B, and C, fucoidan, and dextran sulphate, CD69 dimer gives a weak binding signal with fucoidan.	Polysaccharides	10-25	CD69 molecule	Homo sapiens	103-107
10600606-0	1999	Glycans and proteoglycans are involved in the interactions of human immunodeficiency virus type 1 envelope glycoprotein and of SDF-1alpha with membrane ligands of CD4(+) CXCR4(+) cells.	Polysaccharides	0-7	CD4 molecule	Homo sapiens	163-166
10600606-0	1999	Glycans and proteoglycans are involved in the interactions of human immunodeficiency virus type 1 envelope glycoprotein and of SDF-1alpha with membrane ligands of CD4(+) CXCR4(+) cells.	Polysaccharides	0-7	C-X-C motif chemokine receptor 4	Homo sapiens	170-175
10600606-7	1999	These data demonstrate that glycans and glycosaminoglycans are directly or indirectly involved in the interactions of HIV-1 gp120(LAI) and of SDF-1alpha with membrane ligands of CD4(+) CXCR4(+) cells and thus could play a role both in HIV-1 infection and in the physiology of SDF-1alpha.	Polysaccharides	28-35	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	124-129
10600606-7	1999	These data demonstrate that glycans and glycosaminoglycans are directly or indirectly involved in the interactions of HIV-1 gp120(LAI) and of SDF-1alpha with membrane ligands of CD4(+) CXCR4(+) cells and thus could play a role both in HIV-1 infection and in the physiology of SDF-1alpha.	Polysaccharides	28-35	CD4 molecule	Homo sapiens	178-181
10600606-7	1999	These data demonstrate that glycans and glycosaminoglycans are directly or indirectly involved in the interactions of HIV-1 gp120(LAI) and of SDF-1alpha with membrane ligands of CD4(+) CXCR4(+) cells and thus could play a role both in HIV-1 infection and in the physiology of SDF-1alpha.	Polysaccharides	28-35	C-X-C motif chemokine receptor 4	Homo sapiens	185-190
10584881-4	1999	We report here the application of fluorescence labelling, sequential exoglycosidase digestion, high-performance liquid chromatography and matrix-assisted laser desorption ionization in time-of-flight mass spectrometry, to determine the glycan structures of purified serum AFP from patients with HCC and NSGCT.	Polysaccharides	236-242	alpha fetoprotein	Homo sapiens	272-275
10584881-7	1999	The O-linked glycans (three mucin O-GalNAc type glycans with variable degrees of sialylation, one O-HexNAc monosaccharide glycan) have not previously been reported.	Polysaccharides	13-20	LOC100508689	Homo sapiens	28-33
10584881-8	1999	The finding of mucin O-GalNAc type glycans was supported by the prediction of potential O-GalNAc glycosylation sites on the protein backbone by analysis of the AFP structure by molecular modelling.	Polysaccharides	35-42	LOC100508689	Homo sapiens	15-20
10584881-8	1999	The finding of mucin O-GalNAc type glycans was supported by the prediction of potential O-GalNAc glycosylation sites on the protein backbone by analysis of the AFP structure by molecular modelling.	Polysaccharides	35-42	alpha fetoprotein	Homo sapiens	160-163
10559782-7	1999	Although the presence of N-CAM 180 on astrocytes was controversial until recently, the results shown here indicate that N-CAM 180 exists on rat astrocytes and exclusively carries a glycan structure reacting with DSA.	Polysaccharides	181-187	neural cell adhesion molecule 1	Rattus norvegicus	120-125
10559782-10	1999	Whether each N-CAM with different glycans participates in different functions remains to be established.	Polysaccharides	34-41	neural cell adhesion molecule 1	Rattus norvegicus	13-18
10561463-0	1999	The glycan processing and site occupancy of recombinant Thy-1 is markedly affected by the presence of a glycosylphosphatidylinositol anchor.	Polysaccharides	4-10	thy-1 membrane glycoprotein	Cricetulus griseus	56-61
11094330-4	1999	The anticoagulant activity of this polysaccharide is mediated by both antithrombin and heparin cofactor II; it has antithrombotic activity when targeted at the intrinsic coagulation pathway.	Polysaccharides	35-49	serpin family C member 1	Homo sapiens	70-82
10553075-7	1999	A rabbit antiserum raised against purified rPhl p 6 identified it as a pollen-specific protein that, by immunogold electron microscopy, was localized on the polysaccharide-containing wall-precursor bodies (P-particles).	Polysaccharides	157-171	S100 calcium binding protein A12	Homo sapiens	48-51
10559446-3	1999	Calreticulin carries two glycans of the typical ER high-mannose form.	Polysaccharides	25-32	calreticulin	Homo sapiens	0-12
10559446-10	1999	This result shows that calreticulin is rapidly secreted once complex glycans have been synthesized in the medial/trans Golgi apparatus and that the modified protein does not appear to recycle back to the ER.	Polysaccharides	69-76	calreticulin	Homo sapiens	23-35
10564662-1	1999	In mammalian cells, the calnexin/calreticulin chaperones play a key role in glycoprotein folding and its control within the endoplasmic reticulum (ER), by interacting with folding intermediates via their monoglucosylated glycans.	Polysaccharides	221-228	calnexin	Homo sapiens	24-32
10564662-1	1999	In mammalian cells, the calnexin/calreticulin chaperones play a key role in glycoprotein folding and its control within the endoplasmic reticulum (ER), by interacting with folding intermediates via their monoglucosylated glycans.	Polysaccharides	221-228	calreticulin	Homo sapiens	33-45
10562535-3	1999	We solved the beta(2)GPI structure from a crystal form with 84% solvent and present a model containing all 326 amino acid residues and four glycans.	Polysaccharides	140-147	apolipoprotein H	Homo sapiens	14-24
10534758-4	1999	Next, successive chemical treatments allowed us to remove the neutral glycan moiety of thyroidal GPI, and its composition was obtained by gas chromatography.	Polysaccharides	70-76	glucose-6-phosphate isomerase	Homo sapiens	97-100
10531198-5	1999	To emphasize the carrier properties of rP40, a polysaccharide derived from Haemophilus influenzae type b (Hib) was coupled to it.	Polysaccharides	47-61	LanC like 1	Rattus norvegicus	39-43
10531198-8	1999	In addition, rP40 compares well with the reference carrier protein, tetanus toxoid (TT), since antibody responses of equal intensity were observed when a peptide or a polysaccharide was coupled to TT and rP40.	Polysaccharides	167-181	LanC like 1	Rattus norvegicus	13-17
10528159-3	1999	However, CCR5-/- mice had defects in leukocyte recruitment into the brain and, strikingly, in elimination of cryptococcal polysaccharide from the brain.	Polysaccharides	122-136	chemokine (C-C motif) receptor 5	Mus musculus	9-13
10598748-8	1999	Also, an increase in the number of unsialylated or neutral glycans may increase the volume of distribution of NIF, although this effect is marginal.	Polysaccharides	59-66	zinc finger protein 335	Rattus norvegicus	110-113
10571009-3	1999	Due to the deficiency of terminal N-acetylneuraminic acid or sialic acid, the glycan changes can be observed in serum transferrin or other glycoproteins using isoelectrofocusing with immunofixation as the most widely used diagnostic technique.	Polysaccharides	78-84	transferrin	Homo sapiens	118-129
10574203-2	1999	Glycans released from the tryptic peptide mixture by PNGase F digestion were then derivatised with 2-aminoacridone.	Polysaccharides	0-7	N-glycanase 1	Homo sapiens	53-59
10571011-5	1999	Fine structure analysis of this glycan suggested a defect in the Golgi enzyme UDP-GlcNAc:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II (GnT II; EC 2.4.1.143) which catalyzes an essential step in the biosynthetic pathway leading from hybrid to complex N-glycans.	Polysaccharides	32-38	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	78-152
10571011-5	1999	Fine structure analysis of this glycan suggested a defect in the Golgi enzyme UDP-GlcNAc:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II (GnT II; EC 2.4.1.143) which catalyzes an essential step in the biosynthetic pathway leading from hybrid to complex N-glycans.	Polysaccharides	32-38	alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	154-160
10564478-7	1999	In in vitro assays, the glycosyl transferase of the PBP catalyses the synthesis of linear glycan chains from the lipid carrier with an efficiency of congruent with 39 000 M-1 s-1.	Polysaccharides	90-96	phosphatidylethanolamine binding protein 1	Homo sapiens	52-55
10540333-0	1999	Anti-CD40 antibody enhances responses to polysaccharide without mimicking T cell help.	Polysaccharides	41-55	CD40 antigen	Mus musculus	5-9
10540333-3	1999	Recent studies have proposed the use of anti-CD40 antibody to increase responsivenesses to polysaccharide antigens.	Polysaccharides	91-105	CD40 antigen	Mus musculus	45-49
10540333-4	1999	We show here that the IgG response to a model polysaccharide antigen is greatly increased, but retains thymus-independent characteristics--switching continues to be mainly to IgG3 and neither germinal centers nor memory B cells are formed.	Polysaccharides	46-60	Immunoglobulin heavy constant gamma 3	Mus musculus	175-179
10540166-8	1999	It can be concluded that patients with recurrent sinopulmonary infections and a mild IgG1 subclass deficiency have an impaired IgG1 anti-polysaccharide response, which can extend to decreased IgG2 and IgA anti-polysaccharide responses.	Polysaccharides	137-151	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	201-204
10540166-8	1999	It can be concluded that patients with recurrent sinopulmonary infections and a mild IgG1 subclass deficiency have an impaired IgG1 anti-polysaccharide response, which can extend to decreased IgG2 and IgA anti-polysaccharide responses.	Polysaccharides	210-224	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	201-204
10504403-6	1999	Most glycan structures are proximally alpha1-6-fucosylated, diantennary complex-type bearing nonsialylated or alpha2-6-sialylated N-acetyllactosamine or di-N-acetyllactosamine antennae.	Polysaccharides	5-11	adrenoceptor alpha 1D	Homo sapiens	38-46
10504403-6	1999	Most glycan structures are proximally alpha1-6-fucosylated, diantennary complex-type bearing nonsialylated or alpha2-6-sialylated N-acetyllactosamine or di-N-acetyllactosamine antennae.	Polysaccharides	5-11	immunoglobulin binding protein 1	Homo sapiens	110-118
10564478-18	1999	This substrate specificity suggests that carbonyl donor activity requires the attachment of the pentapeptides to the glycan chains made by the glycosyl transferase, and it implies that one and the same PBP molecule catalyses transglycosylation and peptide cross-linking in a sequential manner.	Polysaccharides	117-123	phosphatidylethanolamine binding protein 1	Homo sapiens	202-205
10517829-1	1999	To obtain information on the synthesis and function of arabinosylated glycans, the mur4 mutant of Arabidopsis was characterized.	Polysaccharides	70-77	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	83-87
10520960-0	1999	Isolation and analysis of a novel acidic polysaccharide from the case of squid pen.	Polysaccharides	41-55	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	79-82
10520960-1	1999	A new non-sulphated acidic polysaccharide with an average molecular mass of 55 kDa was isolated from squid pen case after papain digestion and beta-elimination.	Polysaccharides	27-41	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	107-110
10456887-3	1999	The mechanism involves specific bacterial recruitment of heparin, glycosaminoglycans, or related sulfated polysaccharides, which in turn serve as universal binding sites for a diverse array of mammalian heparin binding proteins, including adhesive glycoproteins (vitronectin and fibronectin), inflammatory (MCP-3, PF-4, and MIP-1alpha) and immunomodulatory (gamma interferon) intermediates, and fibroblast growth factor.	Polysaccharides	106-121	vitronectin	Homo sapiens	263-274
12205959-5	1999	RESULT: A water-soluble polysaccharide with mean molecular weight of 2.47 x 10(14), named Co-4, was obtained.	Polysaccharides	24-38	complement C4A (Rodgers blood group)	Homo sapiens	90-94
12205959-7	1999	CONCLUSION: A thorough study on the polysaccharides of Fructus Corni has been made for the first time and the structure of Co-4 has been elucidated.	Polysaccharides	36-51	complement C4A (Rodgers blood group)	Homo sapiens	123-127
10477568-6	1999	Therapy of mice with glucan- or mannan-rich soluble polysaccharides exhibiting high affinity for CR3 caused a 57-90% reduction in tumor weight.	Polysaccharides	52-67	integrin alpha M	Mus musculus	97-100
10477568-9	1999	Thus, the tumoricidal function of CR3-binding polysaccharides such as beta-glucan in vivo is defined by natural and elicited Abs that direct iC3b deposition onto neoplastic cells, making them targets for circulating leukocytes bearing polysaccharide-primed CR3.	Polysaccharides	46-61	integrin alpha M	Mus musculus	34-37
10477568-9	1999	Thus, the tumoricidal function of CR3-binding polysaccharides such as beta-glucan in vivo is defined by natural and elicited Abs that direct iC3b deposition onto neoplastic cells, making them targets for circulating leukocytes bearing polysaccharide-primed CR3.	Polysaccharides	46-61	integrin alpha M	Mus musculus	257-260
10477568-9	1999	Thus, the tumoricidal function of CR3-binding polysaccharides such as beta-glucan in vivo is defined by natural and elicited Abs that direct iC3b deposition onto neoplastic cells, making them targets for circulating leukocytes bearing polysaccharide-primed CR3.	Polysaccharides	46-60	integrin alpha M	Mus musculus	34-37
10477568-9	1999	Thus, the tumoricidal function of CR3-binding polysaccharides such as beta-glucan in vivo is defined by natural and elicited Abs that direct iC3b deposition onto neoplastic cells, making them targets for circulating leukocytes bearing polysaccharide-primed CR3.	Polysaccharides	46-60	integrin alpha M	Mus musculus	257-260
10464335-9	1999	The PLA(2)-modified LDL has about 2 times higher affinity for the sulfated polysaccharides than control LDL.	Polysaccharides	75-90	phospholipase A2 group IB	Homo sapiens	4-10
10460833-0	1999	Characterization of human vascular endothelial cadherin glycans.	Polysaccharides	56-63	cadherin 5	Homo sapiens	26-55
10460833-4	1999	The results revealed that VE-cadherin carries predominantly sialylated diantennary and hybrid-type glycans in addition to some triantennary and high mannose-type species.	Polysaccharides	99-106	cadherin 5	Homo sapiens	26-37
10464296-2	1999	HNK-1 glycan, sulfo--&gt;3GlcAbeta1--&gt;3Galbeta1--&gt;4GlcNAc--&gt;R, is uniquely enriched in neural cells and natural killer cells and is thought to play important roles in cell-cell interaction.	Polysaccharides	6-12	beta-1,3-glucuronyltransferase 1	Homo sapiens	0-5
10464296-3	1999	HNK-1 glycan synthesis is dependent on HNK-1 sulfotransferase (HNK-1ST), and cDNAs encoding human and rat HNK-1ST have been recently cloned.	Polysaccharides	6-12	beta-1,3-glucuronyltransferase 1	Homo sapiens	0-5
10464296-3	1999	HNK-1 glycan synthesis is dependent on HNK-1 sulfotransferase (HNK-1ST), and cDNAs encoding human and rat HNK-1ST have been recently cloned.	Polysaccharides	6-12	carbohydrate sulfotransferase 10	Homo sapiens	39-61
10464296-3	1999	HNK-1 glycan synthesis is dependent on HNK-1 sulfotransferase (HNK-1ST), and cDNAs encoding human and rat HNK-1ST have been recently cloned.	Polysaccharides	6-12	carbohydrate sulfotransferase 10	Homo sapiens	63-70
10456887-3	1999	The mechanism involves specific bacterial recruitment of heparin, glycosaminoglycans, or related sulfated polysaccharides, which in turn serve as universal binding sites for a diverse array of mammalian heparin binding proteins, including adhesive glycoproteins (vitronectin and fibronectin), inflammatory (MCP-3, PF-4, and MIP-1alpha) and immunomodulatory (gamma interferon) intermediates, and fibroblast growth factor.	Polysaccharides	106-121	C-C motif chemokine ligand 3	Homo sapiens	324-334
10456887-3	1999	The mechanism involves specific bacterial recruitment of heparin, glycosaminoglycans, or related sulfated polysaccharides, which in turn serve as universal binding sites for a diverse array of mammalian heparin binding proteins, including adhesive glycoproteins (vitronectin and fibronectin), inflammatory (MCP-3, PF-4, and MIP-1alpha) and immunomodulatory (gamma interferon) intermediates, and fibroblast growth factor.	Polysaccharides	106-121	fibronectin 1	Homo sapiens	279-290
10456887-3	1999	The mechanism involves specific bacterial recruitment of heparin, glycosaminoglycans, or related sulfated polysaccharides, which in turn serve as universal binding sites for a diverse array of mammalian heparin binding proteins, including adhesive glycoproteins (vitronectin and fibronectin), inflammatory (MCP-3, PF-4, and MIP-1alpha) and immunomodulatory (gamma interferon) intermediates, and fibroblast growth factor.	Polysaccharides	106-121	C-C motif chemokine ligand 7	Homo sapiens	307-312
10456887-3	1999	The mechanism involves specific bacterial recruitment of heparin, glycosaminoglycans, or related sulfated polysaccharides, which in turn serve as universal binding sites for a diverse array of mammalian heparin binding proteins, including adhesive glycoproteins (vitronectin and fibronectin), inflammatory (MCP-3, PF-4, and MIP-1alpha) and immunomodulatory (gamma interferon) intermediates, and fibroblast growth factor.	Polysaccharides	106-121	platelet factor 4	Homo sapiens	314-318
10377143-2	1999	Mucosal as well as systemic antibody responses to PS were evoked by peroral or intranasal immunization of BALB/c mice with PS-cholera toxin B subunit (CTB) conjugates entrapped in the alginate microspheres (AM).	Polysaccharides	50-52	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	123-149
10455130-2	1999	In this report we describe the stable transfection of a human pancreatic adenocarcinoma cell line, Panc1-MUC1, with the cDNA for mucin core 2 GlcNAc-transferase (C2GnT), which creates the core 2 beta-1,6 branch in mucin-type glycans.	Polysaccharides	225-232	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	162-167
10438509-9	1999	The model also predicts that three potential N-linked oligosaccharide sites within the LRR domain are clustered together, which may be important in light of recent studies showing ALS glycan involvement in complex formation with IGFBP-3.	Polysaccharides	184-190	insulin like growth factor binding protein 3	Homo sapiens	229-236
10406848-0	1999	Glycosylation of a CNS-specific extracellular matrix glycoprotein, tenascin-R, is dominated by O-linked sialylated glycans and "brain-type" neutral N-glycans.	Polysaccharides	115-122	tenascin R	Homo sapiens	67-77
10406849-0	1999	Vesicular-integral membrane protein, VIP36, recognizes high-mannose type glycans containing alpha1--&gt;2 mannosyl residues in MDCK cells.	Polysaccharides	73-80	lectin, mannose binding 2	Canis lupus familiaris	37-42
10406849-3	1999	It was found that VIP36 recognizes high-mannose type glycans containing alpha1--&gt;2 Man residues and alpha-amino substituted asparagine.	Polysaccharides	53-60	lectin, mannose binding 2	Homo sapiens	18-23
10406849-4	1999	The binding of Vip36 to high-mannose type glycans was independent of Ca(2+)and theoptimal condition was pH 6.0 at 37 degrees C. The concentration at which half inhibition of the binding by Man(7-9).GlcNAc(2).	Polysaccharides	42-49	lectin, mannose binding 2	Homo sapiens	15-20
10406849-7	1999	These results indicate that VIP36 functions as an intracellular lectin recognizing glycoproteins which possess high-mannose type glycans, (Manalpha1--&gt;2)(2-4).Man(5).	Polysaccharides	129-136	lectin, mannose binding 2	Homo sapiens	28-33
10413093-4	1999	(1998) 426, 367-372], using a virus with an identical V3 region, suggested that elimination of this particular glycan reduced the ability of T-tropic HIV to bind to CXCR4 and hence its ability to infect T cell lines.	Polysaccharides	111-117	C-X-C motif chemokine receptor 4	Homo sapiens	165-170
10438364-5	1999	These data support the hypothesis that the ability of neisserial porins to improve the immune response to poorly immunogenic antigens (e.g., polysaccharides) is related to porin-induced increases in B7-2 expression on antigen-presenting cells and enhanced B/T cell interactions.	Polysaccharides	141-156	CD86 antigen	Mus musculus	199-203
10438368-6	1999	The IgM and IgG3 isotype preference in antibody responses to polysaccharide antigens in mice may translate to a lack of toxicity of antigen-antibody complexes during the course of infections with encapsulated pathogens.	Polysaccharides	61-75	immunoglobulin heavy constant mu	Mus musculus	4-7
10438368-6	1999	The IgM and IgG3 isotype preference in antibody responses to polysaccharide antigens in mice may translate to a lack of toxicity of antigen-antibody complexes during the course of infections with encapsulated pathogens.	Polysaccharides	61-75	Immunoglobulin heavy constant gamma 3	Mus musculus	12-16
10480189-3	1999	By inhibiting in a reversible way the hydrolysis of disaccharides and the ultimate steps of the digestion of dietary polysaccharides, alpha-glucosidase inhibitors reduce postprandial blood glucose raise in diabetics.	Polysaccharides	117-132	sucrase-isomaltase	Homo sapiens	134-151
10377143-2	1999	Mucosal as well as systemic antibody responses to PS were evoked by peroral or intranasal immunization of BALB/c mice with PS-cholera toxin B subunit (CTB) conjugates entrapped in the alginate microspheres (AM).	Polysaccharides	50-52	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	151-154
10411623-1	1999	Human gastric lipase (HGL) is a highly glycosylated protein, as glycan chains account for about 15% of the molecular mass of the native HGL.	Polysaccharides	64-70	lipase F, gastric type	Homo sapiens	6-20
10358040-2	1999	Thymidine diphosphate (dTDP)-D-fucose is the activated nucleotide sugar form of D-fucose, which has been identified as a constituent of structural polysaccharides in only a few bacteria.	Polysaccharides	147-162	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	23-27
10358040-3	1999	In this paper, we show that three dTDP-D-fucose synthetic enzymes are encoded by genes in the gene cluster responsible for the synthesis of serotype b-specific polysaccharide in A. actinomycetemcomitans.	Polysaccharides	160-174	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	34-38
10397812-2	1999	Detailed analysis of the N-glycosylation of recombinant human IFN-gamma by matrix-assisted laser-desorption mass spectrometry showed that the protein secreted by Chinese hamster ovary and baculovirus-infected insect Sf9 cells was associated with complex sialylated or truncated tri-mannosyl core glycans, respectively.	Polysaccharides	296-303	interferon gamma	Homo sapiens	62-71
10643211-8	1999	The alpha-glucosidase inhibitors act nonsystemically by blocking the metabolism of digested polysaccharides and therefore lowering the amount of carbohydrate absorbed in a meal.	Polysaccharides	92-107	sucrase-isomaltase	Homo sapiens	4-21
10520252-2	1999	This hexasaccharide represents a portion of the serotype-specific capsular polysaccharide of Type VIII that has the tetrasaccharide repeat unit [beta-L-Rhap-(1--&gt;4)-beta-D-Glcp-(1--&gt;4)-[alpha-Neu5Ac-(2--&gt; 3)]-beta-D- Galp-(1--&gt;4)]n. A tetrasaccharide corresponding to this repeat unit has been synthesized by us [E. Eichler, H.J.	Polysaccharides	75-89	galanin like peptide	Homo sapiens	226-230
10357807-0	1999	Functional glycan-free adhesion domain of human cell surface receptor CD58: design, production and NMR studies.	Polysaccharides	11-17	CD58 molecule	Homo sapiens	70-74
10411623-1	1999	Human gastric lipase (HGL) is a highly glycosylated protein, as glycan chains account for about 15% of the molecular mass of the native HGL.	Polysaccharides	64-70	lipase F, gastric type	Homo sapiens	22-25
10411623-1	1999	Human gastric lipase (HGL) is a highly glycosylated protein, as glycan chains account for about 15% of the molecular mass of the native HGL.	Polysaccharides	64-70	lipase F, gastric type	Homo sapiens	136-139
10325309-1	1999	A monoclonal antibody against the O-antigenic polysaccharide chain of the lipopolysaccharide (LPS) of Acinetobacter strains belonging to the unnamed genomic species 13 Sensu Tjernberg and Ursing (13TU) was obtained after immunization of BALB/c mice with heat-killed bacteria and was characterized by enzyme immunoassay and Western blot analysis, by use of LPS and proteinase K-treated bacterial lysates, analyses in which the antibody was shown to be highly specific for the homologous antigen.	Polysaccharides	46-60	toll-like receptor 4	Mus musculus	94-97
10232599-3	1999	Interrupting biosynthesis of these surface glycans by inhibition of alpha(1,3)fucosyltransferase (FUT) gene expression is an attractive goal for functional and therapeutic studies.	Polysaccharides	43-50	fucosyltransferase 7	Homo sapiens	68-96
10371246-2	1999	Among those products, the capsular-like polysaccharide antigen (CPA) from A. actinomycetemcomitans is a potent mediator of bone resorption.	Polysaccharides	40-54	carboxypeptidase A1, pancreatic	Mus musculus	64-67
10371246-11	1999	Therefore, this study has shown that CPA from A. actinomycetemcomitans contains a potent antiproliferative polysaccharide whose activity is associated with apoptotic cell death in MC3T3-E1, and that CPA per se is an inducer of apoptosis mediated by the Fas system but not by NO.	Polysaccharides	107-121	carboxypeptidase A1, pancreatic	Mus musculus	37-40
10232599-3	1999	Interrupting biosynthesis of these surface glycans by inhibition of alpha(1,3)fucosyltransferase (FUT) gene expression is an attractive goal for functional and therapeutic studies.	Polysaccharides	43-50	fucosyltransferase 7	Homo sapiens	98-101
10355508-12	1999	A highly statistically significant positive correlation of fucosylated glycans was observed between AAT and TF in both HCC and liver cirrhosis, but not between AFP and AAT or between AFP and TF.	Polysaccharides	71-78	serpin family A member 1	Homo sapiens	100-103
10328871-3	1999	A variety of GAGs (heparin, heparan sulfate, chondroitin sulfate and hyaluronic acid), and a related sulfated polysaccharide (dextran sulfate), were found to interact with IFN-gamma as determined by inhibition of the binding of [125I]IFN-gamma to COLO-205 cells and binding to wells coated with GAGs.	Polysaccharides	110-124	interferon gamma	Homo sapiens	172-181
10328871-3	1999	A variety of GAGs (heparin, heparan sulfate, chondroitin sulfate and hyaluronic acid), and a related sulfated polysaccharide (dextran sulfate), were found to interact with IFN-gamma as determined by inhibition of the binding of [125I]IFN-gamma to COLO-205 cells and binding to wells coated with GAGs.	Polysaccharides	110-124	interferon gamma	Homo sapiens	234-243
10207184-5	1999	The isomeric Lewis x glycans proved to be recognized in highly variable binding modes by polylactosamine-metabolizing enzymes, e.g., the midchain beta1,6-GlcNAc transferase (Leppanen et al., Biochemistry, 36, 13729-13735, 1997).	Polysaccharides	21-28	glucosaminyl (N-acetyl) transferase 3, mucin type	Homo sapiens	146-172
10418103-10	1999	Thus, the control of the ZPG glycan chains over proacrosin activation may regulate both sperm penetration rate and limited proteolysis of zona pellucida proteins.	Polysaccharides	29-35	acrosin	Homo sapiens	48-58
10103052-4	1999	Mimicking some of these saccharide structures, we have synthesized enzymatically a bivalent [sialyl diLex]-glycan, Neu5Acalpha2-3"Lexbeta1-3"Lexbeta1-3"(Neu5Acalpha2-3"Lexbeta1-3Lexbe ta1-6")LN [where Neu5Ac is N-acetylneuraminic acid, Lex is the trisaccharide Galbeta1-4(Fucalpha1-3)GlcNAc and LN is the disaccharide Galbeta1-4GlcNAc].	Polysaccharides	107-113	fucosyltransferase 4	Homo sapiens	102-105
10187834-1	1999	The LEC11 Chinese hamster ovary (CHO) gain-of-function mutant expresses an alpha(1,3)fucosyltransferase (alpha(1,3)Fuc-T) activity that generates the LeX, sialyl-LeX, and VIM-2 glycan determinants and has been extensively used for studies of E-selectin ligand specificity.	Polysaccharides	177-183	alpha(1,3)fucosyltransferase	Cricetulus griseus	75-103
10103052-9	1999	These data show that the bivalent [sialyl diLex]-glycan is a high affinity ligand for L-selectin, and may reduce extravasation of lymphocytes at sites of inflammation in vivo without severely endangering the normal recirculation of lymphocytes via lymph nodes.	Polysaccharides	49-55	selectin L	Homo sapiens	86-96
10234550-0	1999	Suppressive effects of serum on the LPS-induced production of nitric oxide and TNF-alpha by a macrophage-like cell line, WEHI-3, are dependent on the structure of polysaccharide chains in LPS.	Polysaccharides	163-177	toll-like receptor 4	Mus musculus	36-39
10089214-1	1999	We found that human peripheral B and T cells differed in the surface expression of alpha2-6 sialylated type 2 chain glycans.	Polysaccharides	116-123	immunoglobulin binding protein 1	Homo sapiens	83-91
10234550-0	1999	Suppressive effects of serum on the LPS-induced production of nitric oxide and TNF-alpha by a macrophage-like cell line, WEHI-3, are dependent on the structure of polysaccharide chains in LPS.	Polysaccharides	163-177	tumor necrosis factor	Mus musculus	79-88
10234550-0	1999	Suppressive effects of serum on the LPS-induced production of nitric oxide and TNF-alpha by a macrophage-like cell line, WEHI-3, are dependent on the structure of polysaccharide chains in LPS.	Polysaccharides	163-177	toll-like receptor 4	Mus musculus	188-191
10234550-9	1999	These results suggest that the ability of FCS to suppress LPS-induced activation of WEHI-3 cells in mainly dependent on the structure of polysaccharide chains and also on the concentration of LPS employed.	Polysaccharides	137-151	toll-like receptor 4	Mus musculus	58-61
10094703-4	1999	The most informative lon mutant overproduced capsular polysaccharide (RcsA stabilized) yet was resistant to DNA-damaging agents (SulA degraded).	Polysaccharides	54-68	putative ATP-dependent Lon protease	Escherichia coli	21-24
10024667-4	1999	Monosaccharide and amino acid compositional analyses indicated that the MG1 subunits had similar glycan structures on the same polypeptide.	Polysaccharides	97-103	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	72-75
10051440-2	1999	We show that phagocytosis of zymosan by inflammatory peritoneal macrophages potently alters glycan processing of macrosialin in vitro.	Polysaccharides	92-98	CD68 antigen	Mus musculus	113-124
10024667-3	1999	Two differently-charged populations of MG1 subunits were observed which showed different reactivity with monoclonal antibodies to glycan epitopes.	Polysaccharides	130-136	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	39-42
10070964-0	1999	Human colon adenocarcinomas express a MUC1-associated novel carbohydrate epitope on core mucin glycans defined by a monoclonal antibody (A10) raised against murine Ehrlich tumor cells.	Polysaccharides	95-102	mucin 1, transmembrane	Mus musculus	38-42
10070964-0	1999	Human colon adenocarcinomas express a MUC1-associated novel carbohydrate epitope on core mucin glycans defined by a monoclonal antibody (A10) raised against murine Ehrlich tumor cells.	Polysaccharides	95-102	LOC100508689	Homo sapiens	89-94
10070964-0	1999	Human colon adenocarcinomas express a MUC1-associated novel carbohydrate epitope on core mucin glycans defined by a monoclonal antibody (A10) raised against murine Ehrlich tumor cells.	Polysaccharides	95-102	UDP glucuronosyltransferase 1 family, polypeptide A7C	Mus musculus	137-140
10070964-9	1999	Deglycosylation studies with trifluoromethanesulfonic acid pointed to the involvement of core mucin glycans in the A10 epitope.	Polysaccharides	100-107	LOC100508689	Homo sapiens	94-99
10070964-9	1999	Deglycosylation studies with trifluoromethanesulfonic acid pointed to the involvement of core mucin glycans in the A10 epitope.	Polysaccharides	100-107	UDP glucuronosyltransferase 1 family, polypeptide A7C	Mus musculus	115-118
10070964-12	1999	Taken together, the present results point to A10 defining a core 6-related epitope on core mucin glycans expressed by colon cancer MUC1 not previously associated with human cancer.	Polysaccharides	97-104	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	45-48
10070964-12	1999	Taken together, the present results point to A10 defining a core 6-related epitope on core mucin glycans expressed by colon cancer MUC1 not previously associated with human cancer.	Polysaccharides	97-104	LOC100508689	Homo sapiens	91-96
10070964-12	1999	Taken together, the present results point to A10 defining a core 6-related epitope on core mucin glycans expressed by colon cancer MUC1 not previously associated with human cancer.	Polysaccharides	97-104	mucin 1, cell surface associated	Homo sapiens	131-135
10069885-3	1999	OBJECTIVE: The purpose of this study was to evaluate the measurement by enzyme immunoassay of extracellular polysaccharides of Aspergillus and Penicillium species (EPS-Asp/Pen ) in house dust as a marker for fungal exposure and to study the relations between EPS-Asp/Pen levels and home dampness and respiratory symptoms in children.	Polysaccharides	108-123	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	172-175
10596892-2	1999	We have investigated immunoprecipitated megalin from rat brain, lung and placenta, mouse yolk sac carcinoma and megalin synthesizing carcinoma cell lines, for presence of this unique glycan structure.	Polysaccharides	183-189	LDL receptor related protein 2	Rattus norvegicus	40-47
10374675-0	1999	Differential effect of protein-bound polysaccharide (PSK) on survival of experimental murine tumors.	Polysaccharides	37-51	TAO kinase 2	Mus musculus	53-56
10049729-1	1999	Vomeromodulin, a putative pheromone transporter of the rat vomeronasal organ, was isolated by lectin chromatography, purified, and subjected to a mass spectrometric (MS) system of glycan structural determination.	Polysaccharides	180-186	similar to Vomeromodulin	Rattus norvegicus	0-13
10213468-0	1999	Simple mixing of IFN with a polysaccharide having high liver affinity enables IFN to target to the liver.	Polysaccharides	28-42	interferon alpha 1	Homo sapiens	78-81
10036769-3	1999	Charged glycans accounted for 77 and 80% of the total glycans for the IAP- and SP-purified samples, respectively.	Polysaccharides	8-15	alkaline phosphatase, intestinal	Homo sapiens	70-73
9952400-6	1999	A prominent carrier protein for the type of glycans implicated in LTP regulation in the adult hippocampus was identified as N-syndecan (syndecan-3), a transmembrane proteoglycan that was expressed at the processes of the CA1 pyramidal neurons in an activity-dependent manner.	Polysaccharides	44-51	syndecan 3	Rattus norvegicus	124-134
9952400-6	1999	A prominent carrier protein for the type of glycans implicated in LTP regulation in the adult hippocampus was identified as N-syndecan (syndecan-3), a transmembrane proteoglycan that was expressed at the processes of the CA1 pyramidal neurons in an activity-dependent manner.	Polysaccharides	44-51	syndecan 3	Rattus norvegicus	136-146
9952400-6	1999	A prominent carrier protein for the type of glycans implicated in LTP regulation in the adult hippocampus was identified as N-syndecan (syndecan-3), a transmembrane proteoglycan that was expressed at the processes of the CA1 pyramidal neurons in an activity-dependent manner.	Polysaccharides	44-51	carbonic anhydrase 1	Rattus norvegicus	221-224
10036769-3	1999	Charged glycans accounted for 77 and 80% of the total glycans for the IAP- and SP-purified samples, respectively.	Polysaccharides	54-61	alkaline phosphatase, intestinal	Homo sapiens	70-73
10022502-15	1999	In addition, both alpha3 and beta1 integrin subunits express beta1-6 branched Asn-linked oligosaccharides and short poly-N-acetyllactosamine units (Galbeta1-4GlcNAc-R; n &lt; or = 3), glycans previously implicated in cancer metastasis.Thus, alpha3beta1 integrin expressed by human colon carcinoma cells is a major carrier of oncodevelopmental carbohydrate epitopes whose presence may modulate tumor cell adhesion, migration, and/or invasion.	Polysaccharides	184-191	integrin subunit beta 1	Homo sapiens	29-43
10901671-2	1999	Calibration curves were equivalent for both columns whereas analytical parameters revealed that the TSK column was only slightly more efficient in separating polysaccharide standards.	Polysaccharides	158-172	tsukushi, small leucine rich proteoglycan	Homo sapiens	100-103
9949189-9	1999	It is proposed that the mammary gland beta4-GalNAcT functions in the synthesis of lacdiNAc-based, complex-type glycans frequently occurring on bovine milk glycoproteins.	Polysaccharides	111-118	chondroitin sulfate N-acetylgalactosaminyltransferase 2	Homo sapiens	38-51
9922239-13	1999	These results show that (i) orf3 encodes the enzyme responsible for the addition of the L-serine residue to the K40 backbone and (ii) substitution of individual K40 repeats with L-serine is essential for their recognition and polymerization into the K40 polysaccharide by Wzy.	Polysaccharides	254-268	hypothetical protein	Escherichia coli	28-32
10092871-7	1999	MMP-1 derived from fibroblasts was found to carry mainly alpha 2,3-sialylated complex-type diantennary glycans.	Polysaccharides	103-110	matrix metallopeptidase 1	Homo sapiens	0-5
10092871-8	1999	On the other hand, HT-1080 cells produce MMP-1 that has a heterogeneous glycosylation pattern, comprising diantennary glycans carrying Lewis X, LacdiNAc, sialylated LacdiNAc and GalNAc beta 1,4 (Fuc alpha 1,3)GlcNAc (LacdiNAc analogue of Lewis X) as terminal elements.	Polysaccharides	118-125	matrix metallopeptidase 1	Homo sapiens	41-46
9916123-0	1999	Polysaccharide binding potential of the human A2 or A18 kappa light chain homologues.	Polysaccharides	0-14	immunoglobulin kappa variable 2-29	Homo sapiens	52-55
10022502-15	1999	In addition, both alpha3 and beta1 integrin subunits express beta1-6 branched Asn-linked oligosaccharides and short poly-N-acetyllactosamine units (Galbeta1-4GlcNAc-R; n &lt; or = 3), glycans previously implicated in cancer metastasis.Thus, alpha3beta1 integrin expressed by human colon carcinoma cells is a major carrier of oncodevelopmental carbohydrate epitopes whose presence may modulate tumor cell adhesion, migration, and/or invasion.	Polysaccharides	184-191	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	61-68
9878025-2	1999	It was reasoned that a self hsp60 peptide, p458m, might provide T cell help for a response to the T independent capsular polysaccharide of Streptococcus pneumoniae type 4 (PS4).	Polysaccharides	121-135	heat shock protein family D (Hsp60) member 1	Homo sapiens	28-33
9878025-2	1999	It was reasoned that a self hsp60 peptide, p458m, might provide T cell help for a response to the T independent capsular polysaccharide of Streptococcus pneumoniae type 4 (PS4).	Polysaccharides	121-135	taste 2 receptor member 18 pseudogene	Homo sapiens	172-175
9864219-0	1999	Mechanisms for induction of L-selectin loss from T lymphocytes by a cryptococcal polysaccharide, glucuronoxylomannan.	Polysaccharides	81-95	selectin L	Homo sapiens	28-38
10048309-0	1999	Inhibition of UV-induced immune suppression and interleukin-10 production by plant oligosaccharides and polysaccharides.	Polysaccharides	104-119	interleukin 10	Mus musculus	48-62
9864219-3	1999	The focus here was to determine whether cryptococcal polysaccharides modulate the expression of molecules, such as L-selectin, that are important in extravasation of T cells.	Polysaccharides	53-68	selectin L	Homo sapiens	115-125
9867843-1	1999	UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1, 2-N-acetylglucosaminyltransferase I (GnT I) is a key enzyme in the synthesis of Asn-linked complex and hybrid glycans.	Polysaccharides	162-169	alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase	Homo sapiens	89-94
10784373-0	1999	Protein-bound polysaccharide (PSK) induces cytotoxic activity in the NKL human natural killer cell line.	Polysaccharides	14-28	TAO kinase 2	Homo sapiens	30-33
9930660-7	1998	In the in vitro migration assay from a denuded area of confluent cells, the two sulfated polysaccharides markedly enhanced the migration of endothelial cells in the presence of FGF-1.	Polysaccharides	89-104	fibroblast growth factor 1	Homo sapiens	177-182
9886097-8	1999	The glycosylated rds/peripherin..rom1 complex bound to concanavalin A-Sepharose, suggesting that the glycan is not directly involved in the interaction between these proteins.	Polysaccharides	101-107	peripherin 2	Mus musculus	17-31
9886097-8	1999	The glycosylated rds/peripherin..rom1 complex bound to concanavalin A-Sepharose, suggesting that the glycan is not directly involved in the interaction between these proteins.	Polysaccharides	101-107	rod outer segment membrane protein 1	Mus musculus	33-37
10348708-0	1999	Effects of heparin and related sulfated polysaccharides on tissue factor expression induced by mitogenic and non-mitogenic factors in human vascular smooth muscle cells.	Polysaccharides	40-55	coagulation factor III, tissue factor	Homo sapiens	59-72
12078156-3	1999	RESULT: Four kinds of polysaccharides could obviously decrease the content of serum and liver lipoperoxide(LPO) as well as the content of lipofuscin(LF) in brain and cardiac muscle of aged mice, and also increase the activity of superoxide dismutase(SOD) of red cells in aged mice.	Polysaccharides	22-37	lactoperoxidase	Mus musculus	107-110
9920397-13	1998	Analysis of purified RTI40 shows that the protein contains glycan, some of which is sialic acid.	Polysaccharides	59-65	podoplanin	Rattus norvegicus	21-26
9874234-0	1998	Glycan specificity of myelin-associated glycoprotein and sialoadhesin deduced from interactions with synthetic oligosaccharides.	Polysaccharides	0-6	myelin associated glycoprotein	Homo sapiens	22-52
9874234-0	1998	Glycan specificity of myelin-associated glycoprotein and sialoadhesin deduced from interactions with synthetic oligosaccharides.	Polysaccharides	0-6	sialic acid binding Ig like lectin 1	Homo sapiens	57-69
9874234-1	1998	Myelin-associated glycoprotein (MAG) and sialoadhesin (Sn) bind to sialylated glycans on cell surfaces and are thought to be involved in cell-cell interactions.	Polysaccharides	78-85	myelin associated glycoprotein	Homo sapiens	0-30
9874234-1	1998	Myelin-associated glycoprotein (MAG) and sialoadhesin (Sn) bind to sialylated glycans on cell surfaces and are thought to be involved in cell-cell interactions.	Polysaccharides	78-85	myelin associated glycoprotein	Homo sapiens	32-35
9874234-1	1998	Myelin-associated glycoprotein (MAG) and sialoadhesin (Sn) bind to sialylated glycans on cell surfaces and are thought to be involved in cell-cell interactions.	Polysaccharides	78-85	sialic acid binding Ig like lectin 1	Homo sapiens	41-53
16232425-0	1999	Adhesion of polysaccharides to intact cells and protoplasts of Nicotiana tabacum BY-2 and its stimulative effects on protoplast growth.	Polysaccharides	12-27	F-box protein PP2-B11-like	Nicotiana tabacum	81-85
10343413-4	1999	The 2-AMAC derivatised glycans were then collected from HPLC for matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) analysis and the molecular weights of predicted structures were confirmed.	Polysaccharides	23-30	solute carrier family 35 member G5	Homo sapiens	6-10
12136179-0	1999	The Effect of Polysaccharide Krestin on GPx Gene Expression in Macrophages.	Polysaccharides	14-28	peroxiredoxin 6 pseudogene 2	Mus musculus	40-43
10348708-9	1999	TF expression induced by the growth factors was inhibited by heparin (IC 50: 10-30 microg/ml), and other sulfated polysaccharides (IC 50: 1-5 microg/ml).	Polysaccharides	114-129	coagulation factor III, tissue factor	Homo sapiens	0-2
9930660-8	1998	Finally, a weak inhibitory effect on cell migration was found only with the two polysaccharides at high concentrations (&gt; or = 100 micro/ml) in presence of serum or combined with FGF-2.	Polysaccharides	80-95	fibroblast growth factor 2	Homo sapiens	182-187
9923743-2	1998	A procedure is described where a complex mixture of biologically radiolabelled glycans of gp120, derived from a relatively small number of virus-infected cells may be characterized by a combination of N-glycanase release, single lectin separation, and normal phase HPLC (NP-HPLC).	Polysaccharides	79-86	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	90-95
9856646-8	1998	This suggests that O14:K14 may have a selective advantage in colonising or infecting hospitalised patients and, therefore, that the O14 and K14 polysaccharides themselves may contribute towards the apparent pathogenicity of these serotypes.	Polysaccharides	144-159	immunoglobulin kappa variable 1-37 (non-functional)	Homo sapiens	19-22
9856646-8	1998	This suggests that O14:K14 may have a selective advantage in colonising or infecting hospitalised patients and, therefore, that the O14 and K14 polysaccharides themselves may contribute towards the apparent pathogenicity of these serotypes.	Polysaccharides	144-159	keratin 14	Homo sapiens	140-143
9924263-0	1998	African plant foods rich in non-starch polysaccharides reduce postprandial blood glucose and insulin concentrations in healthy human subjects.	Polysaccharides	39-54	insulin	Homo sapiens	93-100
9883672-0	1998	[VIP36 recognizes high-mannose type glycans in relation to apical membrane traffic].	Polysaccharides	36-43	lectin, mannose binding 2	Homo sapiens	1-6
9820529-2	1998	Even when converted to T-dependent forms through conjugation to foreign proteins, polysaccharides induce responses that are deficient in many respects, such as induction of murine IgG2a Ab, the isotype that mediates optimal complement fixation and opsonization.	Polysaccharides	82-97	immunoglobulin heavy variable V1-9	Mus musculus	180-185
9872110-5	1998	The biosensor analysis revealed that lipopolysaccharide from strain Y4 strongly bound to human C3b, but serotype b-specific polysaccharide antigen did not.	Polysaccharides	41-55	endogenous retrovirus group K member 3	Homo sapiens	95-98
9786844-1	1998	Polysialic acid is a developmentally regulated component in the neural cell adhesion molecule N-CAM which also occurs as the capsular polysaccharide of bacteria causing meningitis.	Polysaccharides	134-148	neural cell adhesion molecule 1	Homo sapiens	94-99
9858065-0	1998	Direct action of a protein-bound polysaccharide, PSK, on transforming growth factor-beta.	Polysaccharides	33-47	TAO kinase 2	Homo sapiens	49-52
9858065-0	1998	Direct action of a protein-bound polysaccharide, PSK, on transforming growth factor-beta.	Polysaccharides	33-47	transforming growth factor beta 1	Homo sapiens	57-88
9858065-1	1998	We investigated the action of a protein-bound polysaccharide, PSK, on transforming growth factor-beta (TGF-beta).	Polysaccharides	46-60	TAO kinase 2	Homo sapiens	62-65
9858065-1	1998	We investigated the action of a protein-bound polysaccharide, PSK, on transforming growth factor-beta (TGF-beta).	Polysaccharides	46-60	transforming growth factor beta 1	Homo sapiens	70-101
9858065-1	1998	We investigated the action of a protein-bound polysaccharide, PSK, on transforming growth factor-beta (TGF-beta).	Polysaccharides	46-60	transforming growth factor beta 1	Homo sapiens	103-111
9808090-0	1998	Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins.	Polysaccharides	24-31	immunoglobulin heavy constant alpha 1	Homo sapiens	19-23
9808090-0	1998	Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins.	Polysaccharides	24-31	immunoglobulin heavy constant alpha 1	Homo sapiens	40-44
9808090-8	1998	It was therefore suggested that the IgA1 glycans played a protective role against aggregation and adhesion and that the underglycosylation of the IgA1 molecule found in IgA nephropathy could be involved in the nonimmunologic glomerular accumulation of IgA1.	Polysaccharides	41-48	immunoglobulin heavy constant alpha 1	Homo sapiens	36-40
9794425-4	1998	When cells were preincubated with the GIPL-derived glycan chain, addition of intact GIPL induced macrophage apoptosis in the presence of IFN-gamma.	Polysaccharides	51-57	interferon gamma	Mus musculus	137-146
9756896-11	1998	The data further suggest that hydroxyamino acid spacing may contribute to the regulation of glycan length, thereby, providing a mechanism for maintaining an optimally expanded, protease resistant, mucin conformation.	Polysaccharides	92-98	LOC100508689	Homo sapiens	197-202
9765244-6	1998	In addition to calnexin binding, we have other pieces of evidence that the full-length intracellular ubiquitinated apoB is glycosylated, because (i) it binds to concanavalin A, and (ii) glycan can be demonstrated in the full-length ubiquitinated apoB by a chemical detection method involving oxidation of adjacent hydroxyl groups in the glycan moiety.	Polysaccharides	186-192	apolipoprotein B	Homo sapiens	115-119
9765244-6	1998	In addition to calnexin binding, we have other pieces of evidence that the full-length intracellular ubiquitinated apoB is glycosylated, because (i) it binds to concanavalin A, and (ii) glycan can be demonstrated in the full-length ubiquitinated apoB by a chemical detection method involving oxidation of adjacent hydroxyl groups in the glycan moiety.	Polysaccharides	337-343	apolipoprotein B	Homo sapiens	115-119
9761736-3	1998	We show here that sulphated polysaccharides (heparin, keratan and chondroitin) inhibit the neurotoxicity of these amyloid fibrils and this appears to be mediated via inhibition of the polymerization of the PrP peptide into fibrils.	Polysaccharides	28-43	prion protein	Homo sapiens	206-209
9868597-3	1998	TH1 showed no reactivity with ovine mucin (98% of glycans as sialyl-Tn) but reacted strongly with desialylated ovine mucin, indicating the epitope for this mab was the Tn-antigen (O-linked GalNAc).	Polysaccharides	50-57	negative elongation factor complex member C/D, Th1l	Mus musculus	0-3
9766755-8	1998	Immunoblot experiments, performed using the specific lectin from Phaseolus vulgaris (Leukoagglutinin form), showed that only the beta1 integrin subunit expressed by T lymphocytes from Szbeta(1-6)+ patients carried these glycans, supporting the concept of the involvement of T-cell glycosylation in the evolution of Sz.	Polysaccharides	220-227	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	129-134
9739080-5	1998	The HB-GAM-induced mRNA localization is specifically inhibited by low concentrations of heparin and by heparitinase treatment of cells, showing that cell-surface heparin-type glycans are required for the effect.	Polysaccharides	175-182	pleiotrophin	Homo sapiens	4-10
9802933-6	1998	Neuraminidase-treatment of U937-precipitated CD45 molecules enhanced the reactivity to most of the isoforms, indicating that the antibodies may bind to asialylated polysaccharides.	Polysaccharides	164-179	neuraminidase 1	Homo sapiens	0-13
9802933-6	1998	Neuraminidase-treatment of U937-precipitated CD45 molecules enhanced the reactivity to most of the isoforms, indicating that the antibodies may bind to asialylated polysaccharides.	Polysaccharides	164-179	protein tyrosine phosphatase receptor type C	Homo sapiens	45-49
9759847-0	1998	Neonatal murine B lymphocytes respond to polysaccharide antigens in the presence of IL-1 and IL-6.	Polysaccharides	41-55	interleukin 1 complex	Mus musculus	84-88
9759847-0	1998	Neonatal murine B lymphocytes respond to polysaccharide antigens in the presence of IL-1 and IL-6.	Polysaccharides	41-55	interleukin 6	Mus musculus	93-97
9759856-1	1998	Bacterial polysaccharides (PS) are T-independent type 2 Ags that elicit restricted Ab responses of IgM and IgG3 in mice and IgM and predominantly IgG2 in humans.	Polysaccharides	10-25	Immunoglobulin heavy constant gamma 3	Mus musculus	107-111
9759856-1	1998	Bacterial polysaccharides (PS) are T-independent type 2 Ags that elicit restricted Ab responses of IgM and IgG3 in mice and IgM and predominantly IgG2 in humans.	Polysaccharides	27-29	Immunoglobulin heavy constant gamma 3	Mus musculus	107-111
9748565-3	1998	The aim of this study was to compare the catalysis of inhibition of blood fIXa by antithrombin in the presence of several sulfated polysaccharides with anticoagulant activity, i.e. heparin, three widely used in therapeutics low molecular weight heparins (LMWH) and fucoidan.	Polysaccharides	131-146	serpin family C member 1	Homo sapiens	82-94
9798992-4	1998	The TFPI accumulation in the HUVEC supernatants depends on the incubation time and polysaccharide concentration.	Polysaccharides	83-97	tissue factor pathway inhibitor	Homo sapiens	4-8
9798992-5	1998	After 30 to 60 minutes of incubation, TFPI concentration (total antigen level) was twice higher in the presence of both polysaccharides than in their absence.	Polysaccharides	120-135	tissue factor pathway inhibitor	Homo sapiens	38-42
9798992-6	1998	After one hour of incubation, in the presence of increasing concentrations of each polysaccharide, an optimal stimulation was observed for 0.5 microg/ml of fucoidan and 5 microg/ml of heparin, as evidenced by a raise of the basal TFPI level: a 2-fold increase for the total antigen and a 3-fold increase for the free antigen.	Polysaccharides	83-97	tissue factor pathway inhibitor	Homo sapiens	230-234
9748349-8	1998	The complete glycan core structure (Man3-GluN) of typical GPI anchors including a mannose side chain and the inositolphosphate moiety was required for maximal insulin-mimetic activity of the PIG compounds with some variations possible with respect to the type of residues coupled to the terminal mannose/inositol as well as the type of linkages involved.	Polysaccharides	13-19	insulin	Sus scrofa	159-166
9693112-4	1998	Bound vitronectin could be dissociated from OpaA-heparin-vitronectin complexes by the addition of excess heparin, indicating that sulphated polysaccharides provided the main linkage between the two proteins.	Polysaccharides	140-155	vitronectin	Cricetulus griseus	6-17
9805364-2	1998	The polysaccharide, which is regarded as a homopolysaccharide, was 6-fold more antithrombin-active than the heparin standard.	Polysaccharides	4-18	serpin family C member 1	Homo sapiens	79-91
9846281-3	1998	In contrast, the frequency of tumor progression was suppressed to 50% (3/6) in the cell lines (QRsP/PSK) established from those arising in the mice treated with an immunopotentiating protein-bound polysaccharide, PSK.	Polysaccharides	197-211	TAO kinase 2	Mus musculus	100-103
9725235-3	1998	In this study we demonstrate that stimulation of IFN-alpha synthesis by HSV is inhibited by a number of monosaccharides, including fucose, N-acetylglucosamine, and N-acetylgalactosamine as well as the yeast polysaccharide mannan, supporting a role for lectin(s) in the IFN-alpha stimulation pathway.	Polysaccharides	207-221	interferon alpha 1	Homo sapiens	49-58
9759919-1	1998	The modulatory effect of heparin and dextran sulfate 500,000 (sulfated polysaccharides) was studied on ATPDase and 5"-nucleotidase activities.	Polysaccharides	71-86	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	103-110
9778105-0	1998	Polysialic acid, a unique glycan that is developmentally regulated by two polysialyltransferases, PST and STX, in the central nervous system: from biosynthesis to function.	Polysaccharides	26-32	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	98-101
9778105-0	1998	Polysialic acid, a unique glycan that is developmentally regulated by two polysialyltransferases, PST and STX, in the central nervous system: from biosynthesis to function.	Polysaccharides	26-32	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	Homo sapiens	106-109
9778105-2	1998	This unique glycan is mainly attached to the neural cell adhesion molecule (N-CAM) and implicated in many morphogenic events of the neural cells by modulating the adhesive property of N-CAM.	Polysaccharides	12-18	neural cell adhesion molecule 1	Homo sapiens	45-74
9778105-2	1998	This unique glycan is mainly attached to the neural cell adhesion molecule (N-CAM) and implicated in many morphogenic events of the neural cells by modulating the adhesive property of N-CAM.	Polysaccharides	12-18	neural cell adhesion molecule 1	Homo sapiens	76-81
9778105-2	1998	This unique glycan is mainly attached to the neural cell adhesion molecule (N-CAM) and implicated in many morphogenic events of the neural cells by modulating the adhesive property of N-CAM.	Polysaccharides	12-18	neural cell adhesion molecule 1	Homo sapiens	184-189
9694721-7	1998	However, CD38-/- mice did exhibit marked deficiencies in antibody responses to T-cell-dependent protein antigens and augmented antibody responses to at least one T-cell-independent type 2 polysaccharide antigen.	Polysaccharides	188-202	CD38 antigen	Mus musculus	9-13
10052588-3	1998	Enzyme modification of glycans was demonstrated by separation of the products of hydrolysis of lactose hydrazone with beta-galactosidase, using hydroxybenzaldehyde-derivatized polystyrene beads.	Polysaccharides	23-30	galactosidase beta 1	Homo sapiens	118-136
10934551-3	1998	METHODS: This study evaluated the safety and immunogenicity of Hib polysaccharide-Neisseria meningitidis outer membrane protein complex conjugate vaccine (PRP-OMPC) in Papua New Guinea.	Polysaccharides	67-81	prion protein	Homo sapiens	155-158
9806348-3	1998	When the LHR was down-regulated by excess unlabeled hormone, the LHR-independent incorporation of [125I]pLH could be inhibited in a dose-dependent fashion by sulfated polysaccharides such as fucoidan or chondroitin-(4 or 6)-sulfate, but not by other polyanionic compounds, nor by sulfated chondroitin disaccharides.	Polysaccharides	167-182	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	9-12
9806348-3	1998	When the LHR was down-regulated by excess unlabeled hormone, the LHR-independent incorporation of [125I]pLH could be inhibited in a dose-dependent fashion by sulfated polysaccharides such as fucoidan or chondroitin-(4 or 6)-sulfate, but not by other polyanionic compounds, nor by sulfated chondroitin disaccharides.	Polysaccharides	167-182	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	65-68
9693112-4	1998	Bound vitronectin could be dissociated from OpaA-heparin-vitronectin complexes by the addition of excess heparin, indicating that sulphated polysaccharides provided the main linkage between the two proteins.	Polysaccharides	140-155	vitronectin	Cricetulus griseus	57-68
9693112-5	1998	Binding assays with intact micro-organisms substantiated the requirement of sulphated polysaccharides such as heparin and dextran sulphate for the efficient binding of vitronectin to OpaA+ gonococci.	Polysaccharides	86-101	vitronectin	Cricetulus griseus	168-179
9693112-7	1998	Binding assays with dextran sulphates of various sizes indicated that vitronectin binding correlated with the size of the polysaccharide rather than with the amount of OpaA produced by the bacteria.	Polysaccharides	122-136	vitronectin	Cricetulus griseus	70-81
9693112-8	1998	The inability of zero-length cross-linking agents to couple vitronectin to OpaA provided further evidence that sulphated polysaccharides formed the linkage between vitronectin and OpaA.	Polysaccharides	121-136	vitronectin	Cricetulus griseus	164-175
9693112-10	1998	On the basis of our results, we propose a novel mechanism of vitronectin binding in which sulphated polysaccharides act as molecular bridges, linking the glycosaminoglycan-binding sites of vitronectin and gonococcal OpaA.	Polysaccharides	100-115	vitronectin	Cricetulus griseus	61-72
9693112-10	1998	On the basis of our results, we propose a novel mechanism of vitronectin binding in which sulphated polysaccharides act as molecular bridges, linking the glycosaminoglycan-binding sites of vitronectin and gonococcal OpaA.	Polysaccharides	100-115	vitronectin	Cricetulus griseus	189-200
9699670-2	1998	We report here a novel formula of hydrophobized polysaccharide nanoparticles, which can deliver a HER2 oncoprotein containing an epitope peptide to the MHC class I pathway.	Polysaccharides	48-62	erb-b2 receptor tyrosine kinase 2	Mus musculus	98-102
9698230-6	1998	Based on the integrated peak area for each compound in the chromatograms, the percentage for each glycan was utilized to quantify the glycosylation pattern of the interferon-gamma.	Polysaccharides	98-104	interferon gamma	Cricetulus griseus	163-179
9699670-3	1998	A protein consisting of the 147 amino-terminal amino acids of oncogene erbB-2/neu/HER2 (HER2) was complexed with two kinds of hydrophobized polysaccharides, cholesteryl group-bearing mannan (CHM) and cholesteryl group-bearing pullulan (CHP), to form nanoparticles (CHM-HER2 and CHP-HER2).	Polysaccharides	140-155	erb-b2 receptor tyrosine kinase 2	Mus musculus	71-77
9699670-3	1998	A protein consisting of the 147 amino-terminal amino acids of oncogene erbB-2/neu/HER2 (HER2) was complexed with two kinds of hydrophobized polysaccharides, cholesteryl group-bearing mannan (CHM) and cholesteryl group-bearing pullulan (CHP), to form nanoparticles (CHM-HER2 and CHP-HER2).	Polysaccharides	140-155	erb-b2 receptor tyrosine kinase 2	Mus musculus	78-81
9699670-3	1998	A protein consisting of the 147 amino-terminal amino acids of oncogene erbB-2/neu/HER2 (HER2) was complexed with two kinds of hydrophobized polysaccharides, cholesteryl group-bearing mannan (CHM) and cholesteryl group-bearing pullulan (CHP), to form nanoparticles (CHM-HER2 and CHP-HER2).	Polysaccharides	140-155	erb-b2 receptor tyrosine kinase 2	Mus musculus	82-86
9699670-3	1998	A protein consisting of the 147 amino-terminal amino acids of oncogene erbB-2/neu/HER2 (HER2) was complexed with two kinds of hydrophobized polysaccharides, cholesteryl group-bearing mannan (CHM) and cholesteryl group-bearing pullulan (CHP), to form nanoparticles (CHM-HER2 and CHP-HER2).	Polysaccharides	140-155	erb-b2 receptor tyrosine kinase 2	Mus musculus	88-92
9684552-4	1998	Spectral analysis of a linear glucose homopolymer demonstrated ITMS to be comparable with data obtained from a triple-quadrupole instrument, and in a study of complex glycans, the feature of MSn enabled the assignment of linkages that cannot be assessed by conventional triple-quadrupole tandem instrumentation.	Polysaccharides	167-174	moesin	Homo sapiens	191-194
9707530-0	1998	Maize endosperm ADP-glucose pyrophosphorylase SHRUNKEN2 and BRITTLE2 subunit interactions ADP-glucose pyrophosphorylase (AGP) represents a key regulatory step in polysaccharide synthesis in organisms ranging from bacteria to plants.	Polysaccharides	163-177	glucose-1-phosphate adenylyltransferase large subunit 2, chloroplastic/amyloplastic	Zea mays	16-45
9707530-0	1998	Maize endosperm ADP-glucose pyrophosphorylase SHRUNKEN2 and BRITTLE2 subunit interactions ADP-glucose pyrophosphorylase (AGP) represents a key regulatory step in polysaccharide synthesis in organisms ranging from bacteria to plants.	Polysaccharides	163-177	glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic/amyloplastic	Zea mays	46-55
9707530-0	1998	Maize endosperm ADP-glucose pyrophosphorylase SHRUNKEN2 and BRITTLE2 subunit interactions ADP-glucose pyrophosphorylase (AGP) represents a key regulatory step in polysaccharide synthesis in organisms ranging from bacteria to plants.	Polysaccharides	163-177	Glucose-1-phosphate adenylyltransferase small subunit 2, chloroplastic/amyloplastic/cytosolic	Zea mays	60-68
9707530-0	1998	Maize endosperm ADP-glucose pyrophosphorylase SHRUNKEN2 and BRITTLE2 subunit interactions ADP-glucose pyrophosphorylase (AGP) represents a key regulatory step in polysaccharide synthesis in organisms ranging from bacteria to plants.	Polysaccharides	163-177	glucose-1-phosphate adenylyltransferase large subunit 2, chloroplastic/amyloplastic	Zea mays	17-46
9707530-0	1998	Maize endosperm ADP-glucose pyrophosphorylase SHRUNKEN2 and BRITTLE2 subunit interactions ADP-glucose pyrophosphorylase (AGP) represents a key regulatory step in polysaccharide synthesis in organisms ranging from bacteria to plants.	Polysaccharides	163-177	glucose-1-phosphate adenylyltransferase large subunit 2, chloroplastic/amyloplastic	Zea mays	122-125
9711778-4	1998	The mechanism of B lymphocyte activation by polysaccharides differs from that of protein antigens and involves co-stimulation by CD21 (type 2 complement receptor).	Polysaccharides	44-59	complement C3d receptor 2	Homo sapiens	129-133
9711778-5	1998	Reduced expression of CD21 on neonatal B lymphocytes can explain unresponsiveness to polysaccharides.	Polysaccharides	85-100	complement C3d receptor 2	Homo sapiens	22-26
9666724-0	1998	Two-dimensional chromatography in the analysis of complex glycans from transferrin.	Polysaccharides	58-65	transferrin	Homo sapiens	71-82
9666724-3	1998	Collected fractions of 2-AMAC-derivatized glycans were analyzed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, before and after desialylation.	Polysaccharides	42-49	solute carrier family 35 member G5	Homo sapiens	25-29
9639594-8	1998	Microsomal carbonic anhydrase from the bowfin air bladder also resembled CA IV in that it appears to be anchored to the membrane via a phosphatidylinositol-glycan linkage which could be cleaved by phosphatidylinositol-specific phospholipase C. Taken together, these results suggest that a membrane-bound carbonic anhydrase isoenzyme resembling mammalian CA IV in terms of inhibition characteristics and membrane attachment is present in the air-breathing organ of one of the most primitive air-breathing vertebrates.	Polysaccharides	156-162	carbonic anhydrase 4	Homo sapiens	73-78
9616153-3	1998	To test this, PC activation by thrombin and factor Xa (fXa) was studied in the presence of these polysaccharides.	Polysaccharides	97-112	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	14-16
9652441-1	1998	Two immunomodulating polysaccharides, poly-(1-6)-beta-glucotriosyl-(1-3)-beta-glucopyranose (PGG)-glucan and Bacteroides fragilis polysaccharide A (PS A), were evaluated for the prevention of mortality and abscess formation associated with experimental intraabdominal sepsis.	Polysaccharides	21-36	aminopeptidase puromycin sensitive	Rattus norvegicus	148-152
9719508-7	1998	Enzymatic assays of microsomal preparations showed that JEDI lacked MPT activity when tested with a repeating unit acceptor but retained wild-type levels of the MPT activity with an LPG glycan core acceptor.	Polysaccharides	186-192	platelet endothelial aggregation receptor 1	Homo sapiens	56-60
9694587-5	1998	ELISA detection method showed that the conjugate via oligosaccharide moieties (glycans) was still recognized not only by the anti-transferrin antibodies but also by the specific cellular receptor, while the conjugate via amino acids failed to display this latter ability.	Polysaccharides	79-86	transferrin	Homo sapiens	130-141
9694587-7	1998	The results reported here indicate that the conjugation procedure through glycans leads to stable and selected transferrin-conjugates fully exhibiting their biological activity.	Polysaccharides	74-81	transferrin	Homo sapiens	111-122
9616153-3	1998	To test this, PC activation by thrombin and factor Xa (fXa) was studied in the presence of these polysaccharides.	Polysaccharides	97-112	coagulation factor X	Homo sapiens	44-53
9616153-3	1998	To test this, PC activation by thrombin and factor Xa (fXa) was studied in the presence of these polysaccharides.	Polysaccharides	97-112	coagulation factor X	Homo sapiens	55-58
9616153-4	1998	With thrombin in the absence of thrombomodulin (TM), these polysaccharides markedly reduced the Km for PC and Gla-domainless PC (GDPC) activation in the presence of Ca2+.	Polysaccharides	59-74	coagulation factor II, thrombin	Homo sapiens	5-13
9616153-4	1998	With thrombin in the absence of thrombomodulin (TM), these polysaccharides markedly reduced the Km for PC and Gla-domainless PC (GDPC) activation in the presence of Ca2+.	Polysaccharides	59-74	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	103-105
9711824-4	1998	The trisaccharide which corresponds to a structural motif occurring in N-glycoprotein glycans from human urokinase, human recombinant protein C, phospholipase A2 as well as O-glycans, was converted into a neoglycoprotein following introduction of a cysteamine-derived spacer group and subsequent activation with thiophosgene.	Polysaccharides	86-93	phospholipase A2 group IB	Homo sapiens	145-161
9637923-7	1998	It was speculated that ERp57 is a generic component of the glycan-dependent ER quality control system.	Polysaccharides	59-65	protein disulfide isomerase family A member 3	Homo sapiens	23-28
9643372-8	1998	Because polysaccharides of the bacterial cell wall stimulate TNF-alpha production by monocyte-macrophages and TNF-alpha was shown to stimulate HIV replication directly on activation of NF-kappa b after binding the long terminal repeat (LTR) sequences of HIV, we measured TNF-alpha production and observed a significant increase in both groups of vaccines.	Polysaccharides	8-23	tumor necrosis factor	Homo sapiens	61-70
9643372-8	1998	Because polysaccharides of the bacterial cell wall stimulate TNF-alpha production by monocyte-macrophages and TNF-alpha was shown to stimulate HIV replication directly on activation of NF-kappa b after binding the long terminal repeat (LTR) sequences of HIV, we measured TNF-alpha production and observed a significant increase in both groups of vaccines.	Polysaccharides	8-23	nuclear factor kappa B subunit 1	Homo sapiens	185-195
9605141-0	1998	Calreticulin and calnexin interact with different protein and glycan determinants during the assembly of MHC class I.	Polysaccharides	62-68	calreticulin	Homo sapiens	0-12
9715405-1	1998	N-Acetylglucosaminyltransferase III (GnT III) catalyses the addition of N-acetylglucosamine through a beta 1-4 linkage to the mannose of the trimannosyl core, resulting in conversion of the concanavalin A (Con A)-reactive glycan into a non-reactive state.	Polysaccharides	222-228	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	0-35
9715405-1	1998	N-Acetylglucosaminyltransferase III (GnT III) catalyses the addition of N-acetylglucosamine through a beta 1-4 linkage to the mannose of the trimannosyl core, resulting in conversion of the concanavalin A (Con A)-reactive glycan into a non-reactive state.	Polysaccharides	222-228	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	37-44
9605141-0	1998	Calreticulin and calnexin interact with different protein and glycan determinants during the assembly of MHC class I.	Polysaccharides	62-68	calnexin	Homo sapiens	17-25
9657442-10	1998	These results suggest that the mechanisms involved in the clearance of polysaccharide chains which support the anti-thrombin activity are different from those of the anti-factor Xa activity and that the enhanced binding properties of plasma proteins to unfractionated heparin reported in patients presenting an acute venous thromboembolism also exists for LMWH, predominantly for the anti-thrombin activity.	Polysaccharides	71-85	coagulation factor II, thrombin	Homo sapiens	116-124
9625695-2	1998	Homozygous su1- mutant endosperms accumulate a highly branched polysaccharide, phytoglycogen, at the expense of the normal branched component of starch, amylopectin.	Polysaccharides	63-77	isoamylase 1, chloroplastic	Zea mays	11-14
9625695-7	1998	Two biochemical assays confirmed that SU1 hydrolyzes alpha-(1--&gt;6) linkages in branched polysaccharides.	Polysaccharides	91-106	isoamylase 1, chloroplastic	Zea mays	38-41
9593692-1	1998	Protease inhibition by secretory leukocyte protease inhibitor (SLPI) is accelerated by the sulfated polysaccharides.	Polysaccharides	100-115	antileukoproteinase	Ovis aries	63-67
9593692-2	1998	The nature of the SLPI-polysaccharide interaction, explored with affinity chromatography, indicated that this interaction was sensitive to the charge and type of polysaccharide.	Polysaccharides	23-37	antileukoproteinase	Ovis aries	18-22
9593692-2	1998	The nature of the SLPI-polysaccharide interaction, explored with affinity chromatography, indicated that this interaction was sensitive to the charge and type of polysaccharide.	Polysaccharides	162-176	antileukoproteinase	Ovis aries	18-22
9597549-1	1998	We have previously provided compelling evidence that human recombinant interleukin 2 (IL-2) binds to the sulfated polysaccharides heparin, highly sulfated heparan sulfate and fucoidan.	Polysaccharides	114-129	interleukin 2	Homo sapiens	71-84
9565563-8	1998	Addition of anionic polysaccharides that activate cathepsin L already at pH 5.5 unfolds the tertiary structure of the propeptide at this pH.	Polysaccharides	20-35	cathepsin L	Homo sapiens	50-61
9605991-2	1998	The TNF-inducing potency of these polysaccharides may depend on their supramolecular configuration.	Polysaccharides	34-49	tumor necrosis factor	Homo sapiens	4-7
9597549-1	1998	We have previously provided compelling evidence that human recombinant interleukin 2 (IL-2) binds to the sulfated polysaccharides heparin, highly sulfated heparan sulfate and fucoidan.	Polysaccharides	114-129	interleukin 2	Homo sapiens	86-90
9574536-0	1998	Induction of Fas ligand in murine bone marrow NK cells by bacterial polysaccharides.	Polysaccharides	68-83	Fas ligand (TNF superfamily, member 6)	Mus musculus	13-23
9881748-0	1998	Reproducible and sensitive determination of charged oligosaccharides from haptoglobin by PNGase F digestion and HPAEC/PAD analysis: glycan composition varies with disease.	Polysaccharides	132-138	haptoglobin	Homo sapiens	74-85
9516154-6	1998	In vitro studies showed a direct effect of G-CSF on K pneumoniae resulting in increased capsular polysaccharide (CPS) production.	Polysaccharides	97-111	colony stimulating factor 3 (granulocyte)	Mus musculus	43-48
9654101-7	1998	The IFN-alpha14c N-glycans were shown to exhibit core-fucosylated biantennary glycans, with about 10% carrying an additional alpha1,3-linked fucose unit at the antennae.	Polysaccharides	19-26	interferon alpha 14	Homo sapiens	4-15
11477927-7	1998	CONCLUSION: CA4, which is mainly composed of acidic polysaccharides, is the main immunomodulating active fraction contained in the ethanol-insoluble fraction of LWDHD.	Polysaccharides	52-67	carbonic anhydrase 4	Mus musculus	12-15
9600268-3	1998	Removal of the glycan appeared to cause a marked reduction of CXCR-4- but not CCR-5-dependent virus entry.	Polysaccharides	15-21	C-X-C motif chemokine receptor 4	Homo sapiens	62-68
16349537-0	1998	Spatial and Temporal Deposition of Adhesive Extracellular Polysaccharide Capsule and Fimbriae by Hyphomonas Strain MHS-3.	Polysaccharides	58-72	MHS3	Homo sapiens	115-120
9514751-3	1998	The glycans were similar to those previously described for class-1 VSGs, in that they contained the linear trimannosyl sequence Manalpha1-2Manalpha1-6Man and a complex alpha-galactose branch of up to Galalpha1-2Galalpha1-6(Galalpha1-2)Gal, but most also contained an additional galactose residue attached alpha1-2 to the non-reducing terminal mannose residue and about one-third contained an additional galactose residue attached beta1-3 to the middle mannose residue.	Polysaccharides	4-11	adrenoceptor alpha 1D	Homo sapiens	131-139
9499382-4	1998	The glycans from normal transferrin consisted predominantly (86%) of the disialylated biantennary complex type.	Polysaccharides	4-11	transferrin	Homo sapiens	24-35
9499382-6	1998	The truncated glycans were deficient in galactose and sialic acid and their structures were consistent with a decrease in galactosyltransferase activity in hepatocytes, the probable cells of origin of the transferrin.	Polysaccharides	14-21	transferrin	Homo sapiens	205-216
9613830-2	1998	The results suggest that the interaction of FGFR-1 with heparin may not be physiologically relevant and that the site of interaction of the polysaccharide on bFGF is more complex than has been anticipated.	Polysaccharides	140-154	fibroblast growth factor 2	Homo sapiens	158-162
9605944-1	1998	MUC1 mucin core protein contains an important tumor-associated peptide antigen that can induce cytotoxic T cells (CTLs) in vivo, although this antigen is generally masked by mucin-type glycans.	Polysaccharides	185-192	mucin 1, cell surface associated	Homo sapiens	0-4
9587963-10	1998	Crystallographic data for IFN-beta-1a revealed that the glycan formed H-bonds with the peptide backbone and shielded an uncharged surface from solvent exposure.	Polysaccharides	56-62	interferon alpha 1	Homo sapiens	26-29
9514751-3	1998	The glycans were similar to those previously described for class-1 VSGs, in that they contained the linear trimannosyl sequence Manalpha1-2Manalpha1-6Man and a complex alpha-galactose branch of up to Galalpha1-2Galalpha1-6(Galalpha1-2)Gal, but most also contained an additional galactose residue attached alpha1-2 to the non-reducing terminal mannose residue and about one-third contained an additional galactose residue attached beta1-3 to the middle mannose residue.	Polysaccharides	4-11	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	430-437
9465784-6	1998	The two beta (1-2) linkages of complex-type glycan had been found to prefer different conformational regime and the terminal fucose linked to the GlcNAc residue drastically modifies the GlcNAc beta (1-4) GlcNAc linkage conformation.	Polysaccharides	44-50	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	8-17
9521847-6	1998	(iii) In addition, sulfated polysaccharides partially protected plasmin from inactivation by alpha 2-antiplasmin.	Polysaccharides	28-43	serpin family F member 2	Homo sapiens	93-112
9521847-7	1998	Sulfated polysaccharides also stimulated tumor-cell associated plasminogen activation, e.g., (iv) cell surface pro-uPA activation by plasmin and (v) plasminogen activation by cell surface uPA.	Polysaccharides	9-24	plasminogen activator, urokinase	Homo sapiens	115-118
9521847-7	1998	Sulfated polysaccharides also stimulated tumor-cell associated plasminogen activation, e.g., (iv) cell surface pro-uPA activation by plasmin and (v) plasminogen activation by cell surface uPA.	Polysaccharides	9-24	plasminogen activator, urokinase	Homo sapiens	188-191
9579671-4	1998	The NMDA receptor subunit NR1 and fractions of gp65 and cadherin were found to carry the epitope, while fucosylation of NCAM180 and NCAM140 obviously occurs via different linkages to the glycan chains.	Polysaccharides	187-193	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	26-29
9473220-3	1998	We have characterized the expression patterns of PrPC during human leukocyte maturation by flow cytometry with monoclonal antibodies to PrPC, the glycan moiety CD15, and the stem cell marker CD34.	Polysaccharides	146-152	prion protein	Homo sapiens	49-53
9579803-0	1998	Determination of glycan structures and molecular masses of the glycovariants of serum transferrin from a patient with carbohydrate deficient syndrome type II.	Polysaccharides	17-23	transferrin	Homo sapiens	86-97
9637747-1	1998	The authors developed a simple and rapid method for quantitation of free capsular polysaccharide of Haemophilus influenzae type b (polyribosyl ribitol phosphate, PRP) in PRP-tetanus toxoid conjugate vaccine based on acid precipitation of tetanus toxoid (TT).	Polysaccharides	82-96	prion protein	Mus musculus	162-165
9579803-5	1998	On the basis of a polypeptide chain molecular mass of 75,143 Da, it was calculated that the major transferrin species III (78,247 Da) contains two monosialylated monoantennary glycans.	Polysaccharides	176-183	transferrin	Homo sapiens	98-109
9579803-6	1998	The molecular mass of transferrin species V and VI (78,678 and 78,971 Da) suggests that one of their two glycans contains an additional N-acetyllactosamine and a sialylated N-acetyllactosamine units, respectively.	Polysaccharides	105-112	transferrin	Homo sapiens	22-33
11326989-0	1998	[High performance liquid chromatographic analysis of monosaccharide composition in lacquer polysaccharide from sap of lac tree].	Polysaccharides	91-105	lactase	Homo sapiens	83-86
9525101-0	1998	Acidic polysaccharide from Panax ginseng, ginsan, induces Th1 cell and macrophage cytokines and generates LAK cells in synergy with rIL-2.	Polysaccharides	7-21	interleukin 2	Rattus norvegicus	132-137
9478973-0	1998	Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids.	Polysaccharides	87-93	beta-1,3-glucuronyltransferase 1	Homo sapiens	81-86
9634715-0	1998	[Sulfated polysaccharides as inhibitors of receptor activity of P-selectin and P-selectin-dependent inflammation].	Polysaccharides	10-25	selectin P	Rattus norvegicus	64-74
9634715-0	1998	[Sulfated polysaccharides as inhibitors of receptor activity of P-selectin and P-selectin-dependent inflammation].	Polysaccharides	10-25	selectin P	Rattus norvegicus	79-89
9478973-0	1998	Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids.	Polysaccharides	87-93	neural cell adhesion molecule 1	Homo sapiens	101-130
9478973-5	1998	The transfected Lec2-NCAM cells expressing the HNK-1 glycan were enriched by fluorescence-activated cell sorting.	Polysaccharides	53-59	adhesion G protein-coupled receptor L1	Homo sapiens	16-20
9478973-5	1998	The transfected Lec2-NCAM cells expressing the HNK-1 glycan were enriched by fluorescence-activated cell sorting.	Polysaccharides	53-59	neural cell adhesion molecule 1	Homo sapiens	21-25
9478973-5	1998	The transfected Lec2-NCAM cells expressing the HNK-1 glycan were enriched by fluorescence-activated cell sorting.	Polysaccharides	53-59	beta-1,3-glucuronyltransferase 1	Homo sapiens	47-52
9544450-5	1998	The bone ALP showed a rapid initial clearance, apparently related to its large glycan heterogeneity and to the presence of molecules with a low sialic acid content.	Polysaccharides	79-85	ATHS	Homo sapiens	9-12
9544461-3	1998	We have recently shown that fragments of the polysaccharide hyaluronan (HA), but not native high molecular weight HA can cause prominent upregulation of the adhesion molecules ICAM-1 and VCAM-1 in renal proximal tubular cells.	Polysaccharides	45-59	intercellular adhesion molecule 1	Homo sapiens	176-182
9544461-3	1998	We have recently shown that fragments of the polysaccharide hyaluronan (HA), but not native high molecular weight HA can cause prominent upregulation of the adhesion molecules ICAM-1 and VCAM-1 in renal proximal tubular cells.	Polysaccharides	45-59	vascular cell adhesion molecule 1	Homo sapiens	187-193
9461592-3	1998	To begin to understand the biosynthesis of these glycans, we have characterized the acceptor and site specificities of the two granulocyte alpha1,3-fucosyltransferases, Fuc-TIV and Fuc-TVII, using recombinant forms of these two enzymes and a panel of synthetic polylactosamine-based acceptors.	Polysaccharides	49-56	fucosyltransferase 4	Homo sapiens	169-176
9461592-3	1998	To begin to understand the biosynthesis of these glycans, we have characterized the acceptor and site specificities of the two granulocyte alpha1,3-fucosyltransferases, Fuc-TIV and Fuc-TVII, using recombinant forms of these two enzymes and a panel of synthetic polylactosamine-based acceptors.	Polysaccharides	49-56	fucosyltransferase 7	Homo sapiens	181-189
9509434-1	1998	BACKGROUND: CD44 is the main receptor for the extracellular polysaccharide hyaluronan (HA).	Polysaccharides	60-74	CD44 antigen	Mus musculus	12-16
9548367-0	1998	Tyrosine and serine phosphorylation of the neural cell adhesion molecule L1 is implicated in its oligomannosidic glycan dependent association with NCAM and neurite outgrowth.	Polysaccharides	113-119	L1 cell adhesion molecule	Mus musculus	43-75
9548367-0	1998	Tyrosine and serine phosphorylation of the neural cell adhesion molecule L1 is implicated in its oligomannosidic glycan dependent association with NCAM and neurite outgrowth.	Polysaccharides	113-119	neural cell adhesion molecule 1	Mus musculus	147-151
9548367-1	1998	We have previously shown that a cis interaction between the cell adhesion molecules L1 and NCAM is mediated by N-linked oligomannosidic glycans carried by L1 and that this L1/NCAM association is involved in basal neurite outgrowth from early postnatal cerebellar neurons of mouse brain [R. Horstkorte et al., J.	Polysaccharides	136-143	neural cell adhesion molecule 1	Mus musculus	91-95
9548367-1	1998	We have previously shown that a cis interaction between the cell adhesion molecules L1 and NCAM is mediated by N-linked oligomannosidic glycans carried by L1 and that this L1/NCAM association is involved in basal neurite outgrowth from early postnatal cerebellar neurons of mouse brain [R. Horstkorte et al., J.	Polysaccharides	136-143	neural cell adhesion molecule 1	Mus musculus	175-179
9492005-2	1998	In addition, it binds the polysaccharide fucoidan, consistent with its C-type lectin homology and the hypothesis that Ly-49A interacts with carbohydrates on Dd.	Polysaccharides	26-40	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	118-124
9524068-5	1998	Treatment of the chymase-fusion protein with enterokinase or the tryptase-fusion protein with enterokinase in the presence of a highly charged polysaccharide (dextran sulfate or heparin) produced enzymatically active proteases with properties of the native enzymes.	Polysaccharides	143-157	chymase 1	Homo sapiens	17-24
9446842-2	1998	Protein-bound polysaccharides (PSP) are biological response modifiers and have been shown to have immunoenhancing and antitumor effects.	Polysaccharides	14-29	persephin	Mus musculus	31-34
10079862-1	1998	Induction of interferon (IF) and tumor necrosis factor (TNF) under the action of two polysaccharide preparations of ginseng i.e. panaxan-1 (from ginseng root) and panaxan-2 (from ginseng cell culture) was studied.	Polysaccharides	85-99	tumor necrosis factor	Homo sapiens	56-59
9521111-2	1998	For inhibition of thrombin, the bridging function of a longer polysaccharide chain is required to accelerate the reaction.	Polysaccharides	62-76	coagulation factor II, thrombin	Homo sapiens	18-26
9599816-4	1998	The importance of the methodology used for NSP determination is underlined, since some methods determine only some of the polysaccharides, other also measure some other substances, whereas Englyst"s method determines NSP only.	Polysaccharides	122-137	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	43-46
9498066-0	1998	Endothelial sialyl Lewis x as a crucial glycan decoration on L-selectin ligands.	Polysaccharides	40-46	selectin L	Homo sapiens	61-71
9442031-4	1998	Thus, as detected by immunoblotting and by 125I-TSH cross-linking to TSHR expressed on the surface of intact CHO cells, trypsin clipped a small polypeptide fragment bearing a glycan moiety from the C terminus of the A subunit.	Polysaccharides	175-181	thyrotropin receptor	Cricetulus griseus	69-73
9457474-0	1998	A review of research on the protein-bound polysaccharide (polysaccharopeptide, PSP) from the mushroom Coriolus versicolor (Basidiomycetes: Polyporaceae).	Polysaccharides	42-56	microseminoprotein beta	Homo sapiens	79-82
9950103-1	1998	Weekly injection of a protein-bound polysaccharide PSK in mice with Lewis Lung Cancer (LLC) significantly decreased the number of lung metastatic foci concomitant with enhancement of cytostatic activity in the bronchoalveolar lavage (BAL) cells.	Polysaccharides	36-50	TAO kinase 2	Mus musculus	51-54
9457474-2	1998	Protein-bound polysaccharides, designated as PSK and PSP, have been isolated from the CM-101 strain and the COV-1 strain, respectively, of the mushroom Coriolus versicolor.	Polysaccharides	14-29	microseminoprotein beta	Homo sapiens	53-56
9457474-7	1998	The presence of fucose in PSK and rhamnose and arabinose in PSP distinguishes the two protein-bound polysaccharides, which are otherwise chemically similar.	Polysaccharides	100-115	microseminoprotein beta	Homo sapiens	60-63
9506829-0	1998	Stimulation of interleukin-8 production by acidic polysaccharides from the root of Panax ginseng.	Polysaccharides	50-65	C-X-C motif chemokine ligand 8	Homo sapiens	15-28
9586785-10	1998	The results showed an inhibition of thrombin generation in contact-activated plasma in the presence of both polysaccharides, with a prolonged lag phase preceding the burst of thrombin generation.	Polysaccharides	108-123	coagulation factor II, thrombin	Homo sapiens	36-44
9427456-5	1997	RESULTS: Total PRP antibody concentrations were 1.50, 14.4 and 20.4 microg/ml in 2-month-old infants born to mothers immunized with polysaccharide, PRP-D and HbOC vaccines, respectively, and 2.54, 1.35 and 2.46 microg/ml in 6-month-old infants.	Polysaccharides	132-146	prion protein	Homo sapiens	15-18
9420286-3	1998	Moreover, this glycan mediates specific association of M with the chaperone calnexin.	Polysaccharides	15-21	calnexin	Homo sapiens	76-84
9420286-5	1998	As proper folding and trafficking of M need the assistance of the chaperone, the glycan-dependent association of M with calnexin may thus play a crucial role in the assembly of HBV.	Polysaccharides	81-87	calnexin	Homo sapiens	120-128
9443938-7	1998	The glycans of tetrameric forms of plasma cholinesterases (human serum butyrylcholinesterase, fetal bovine serum acetylcholinesterase, and equine serum butyrylcholinesterase) clearly demonstrated a reduced heterogeneity and higher maturity compared with glycans of monomeric fetal bovine serum acetylcholinesterase, dimeric tissue-derived T. californica acetylcholinesterase, and recombinant cholinesterases.	Polysaccharides	4-11	acetylcholinesterase	Mus musculus	294-314
9443938-7	1998	The glycans of tetrameric forms of plasma cholinesterases (human serum butyrylcholinesterase, fetal bovine serum acetylcholinesterase, and equine serum butyrylcholinesterase) clearly demonstrated a reduced heterogeneity and higher maturity compared with glycans of monomeric fetal bovine serum acetylcholinesterase, dimeric tissue-derived T. californica acetylcholinesterase, and recombinant cholinesterases.	Polysaccharides	4-11	acetylcholinesterase	Mus musculus	294-314
12168012-4	1998	Indolyl group might be the binding group of acceptor substrate--Gn(2)M(3)Gn(2)-PA heptosaccharide glycan for GnT-III and GnT-IV, and it might be the essential group but not substrate-binding for GnT-V.	Polysaccharides	98-104	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	109-116
12168012-4	1998	Indolyl group might be the binding group of acceptor substrate--Gn(2)M(3)Gn(2)-PA heptosaccharide glycan for GnT-III and GnT-IV, and it might be the essential group but not substrate-binding for GnT-V.	Polysaccharides	98-104	alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B	Homo sapiens	121-127
12168012-4	1998	Indolyl group might be the binding group of acceptor substrate--Gn(2)M(3)Gn(2)-PA heptosaccharide glycan for GnT-III and GnT-IV, and it might be the essential group but not substrate-binding for GnT-V.	Polysaccharides	98-104	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	195-200
9405387-0	1997	Sulfated lewis X determinants as a major structural motif in glycans from LS174T-HM7 human colon carcinoma mucin.	Polysaccharides	61-68	LOC100508689	Homo sapiens	107-112
9505208-0	1997	Protein bound polysaccharide PSK abrogates more efficiently experimental metastases derived from H-2 negative than from H-2 positive fibrosarcoma tumor clones.	Polysaccharides	14-28	TAO kinase 2	Mus musculus	29-32
9505208-0	1997	Protein bound polysaccharide PSK abrogates more efficiently experimental metastases derived from H-2 negative than from H-2 positive fibrosarcoma tumor clones.	Polysaccharides	14-28	histocompatibility-2, MHC	Mus musculus	97-100
9505208-0	1997	Protein bound polysaccharide PSK abrogates more efficiently experimental metastases derived from H-2 negative than from H-2 positive fibrosarcoma tumor clones.	Polysaccharides	14-28	histocompatibility-2, MHC	Mus musculus	120-123
9505208-8	1997	These results clearly suggest that NK cell activation in vivo by the protein bound polysaccharide PSK abrogates metastasis formation in mice.	Polysaccharides	83-97	TAO kinase 2	Mus musculus	98-101
9427456-6	1997	Infants born to mothers immunized with polysaccharide vaccine had significantly less PRP antibody at 2 months of age but similar antibody concentrations at 6 months of age.	Polysaccharides	39-53	prion protein	Homo sapiens	85-88
10851484-1	1997	Melanoidin, which belongs to the melanin group of molecules, was extracted from the polysaccharide biological response modifier PSK.	Polysaccharides	84-98	TAO kinase 2	Homo sapiens	128-131
9358856-1	1997	In a comprehensive study, we examined the expression of the membrane and secretory mucins MUC1 and MUC3, respectively, in normal and neoplastic gastrointestinal and breast epithelia before and after specific alterations of their glycan structures by neuraminidase, alpha-fucosidase, or carbohydrate-specific periodate oxidation.	Polysaccharides	229-235	mucin 1, cell surface associated	Homo sapiens	90-94
9358856-1	1997	In a comprehensive study, we examined the expression of the membrane and secretory mucins MUC1 and MUC3, respectively, in normal and neoplastic gastrointestinal and breast epithelia before and after specific alterations of their glycan structures by neuraminidase, alpha-fucosidase, or carbohydrate-specific periodate oxidation.	Polysaccharides	229-235	neuraminidase 1	Homo sapiens	250-263
18372518-1	1997	CD44 is an integral membrane glycoprotein that functions as a receptor for the extracellular matrix glycan, hyaluronan.	Polysaccharides	100-106	CD44 molecule (Indian blood group)	Homo sapiens	0-4
9357830-1	1997	Insulin-like growth factor (IGF) binding protein 5 (IGFBP-5) mRNA was studied in intestines of rats with peptidoglycan-polysaccharide enterocolitis by Northern analysis and in situ hybridization.	Polysaccharides	118-133	insulin-like growth factor binding protein 5	Rattus norvegicus	0-50
9357830-1	1997	Insulin-like growth factor (IGF) binding protein 5 (IGFBP-5) mRNA was studied in intestines of rats with peptidoglycan-polysaccharide enterocolitis by Northern analysis and in situ hybridization.	Polysaccharides	118-133	insulin-like growth factor binding protein 5	Rattus norvegicus	52-59
9284142-0	1997	Release of tumor necrosis factor alpha in response to Vibrio vulnificus capsular polysaccharide in in vivo and in vitro models.	Polysaccharides	81-95	tumor necrosis factor	Mus musculus	11-38
9287346-2	1997	The last stages of thyroglobulin maturation occur in the thyroid follicular lumen and include thyroid hormone formation and glycan completion.	Polysaccharides	124-130	thyroglobulin	Homo sapiens	19-32
9342049-0	1997	The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis.	Polysaccharides	93-107	sugarless	Drosophila melanogaster	15-24
9299472-1	1997	Fucosyltransferase VII (FucT-VII) is one of five known alpha 1--&gt;3fucosyltransferases capable of transferring fucose to the C-3 position of N-acetylglucosamine residues found in lactosamine based glycans.	Polysaccharides	199-206	fucosyltransferase 7	Homo sapiens	0-22
9299472-1	1997	Fucosyltransferase VII (FucT-VII) is one of five known alpha 1--&gt;3fucosyltransferases capable of transferring fucose to the C-3 position of N-acetylglucosamine residues found in lactosamine based glycans.	Polysaccharides	199-206	fucosyltransferase 7	Homo sapiens	24-32
9236191-6	1997	A glycan-dependent interaction between CD3-epsilon and calnexin was mediated by CD3-gamma and concerned only monomeric CD3-epsilon complexed with CD3-gamma, but was dispensable for proper folding of CD3-epsilon.	Polysaccharides	2-8	CD3 gamma subunit of T-cell receptor complex	Homo sapiens	146-155
9236191-6	1997	A glycan-dependent interaction between CD3-epsilon and calnexin was mediated by CD3-gamma and concerned only monomeric CD3-epsilon complexed with CD3-gamma, but was dispensable for proper folding of CD3-epsilon.	Polysaccharides	2-8	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	119-130
9311148-1	1997	The site-specific glycan heterogeneity of human urinary erythropoietin was investigated by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS).	Polysaccharides	18-24	erythropoietin	Homo sapiens	56-70
9236191-5	1997	In the absence of these subunits, the ER-resident chaperone calnexin interacted with oligomeric, i.e. misfolded, structures of CD3-epsilon in a glycan-independent manner.	Polysaccharides	144-150	calnexin	Homo sapiens	60-68
9236191-6	1997	A glycan-dependent interaction between CD3-epsilon and calnexin was mediated by CD3-gamma and concerned only monomeric CD3-epsilon complexed with CD3-gamma, but was dispensable for proper folding of CD3-epsilon.	Polysaccharides	2-8	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	39-50
9236191-6	1997	A glycan-dependent interaction between CD3-epsilon and calnexin was mediated by CD3-gamma and concerned only monomeric CD3-epsilon complexed with CD3-gamma, but was dispensable for proper folding of CD3-epsilon.	Polysaccharides	2-8	calnexin	Homo sapiens	55-63
9236191-6	1997	A glycan-dependent interaction between CD3-epsilon and calnexin was mediated by CD3-gamma and concerned only monomeric CD3-epsilon complexed with CD3-gamma, but was dispensable for proper folding of CD3-epsilon.	Polysaccharides	2-8	CD3 gamma subunit of T-cell receptor complex	Homo sapiens	80-89
9236191-6	1997	A glycan-dependent interaction between CD3-epsilon and calnexin was mediated by CD3-gamma and concerned only monomeric CD3-epsilon complexed with CD3-gamma, but was dispensable for proper folding of CD3-epsilon.	Polysaccharides	2-8	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	119-130
9264010-2	1997	The increased reactivity of intact or de-sialylated serum IgA1 with N-acetylgalactosamine (GalNAc)-specific lectins, Helix aspersa (HAA) and Caragana arborescens (CAA) and de-sialylated IgA1 with Helix pomatia (HPA) and Bauhinia purpurea (BPA) indicated that the Gal deficiency is in glycans located in the hinge region of IgA1 molecules.	Polysaccharides	284-291	immunoglobulin heavy constant alpha 1	Homo sapiens	58-62
9278899-2	1997	These topical aFGF formulations not only contain low levels of protein mass (50 micrograms ml-1), but also include buffer ions, polysaccharide polyanions to conformationally stabilize aFGF and 1% hydroxyethylcellulose to increase the solution"s viscosity.	Polysaccharides	128-142	fibroblast growth factor 1	Homo sapiens	14-18
9300139-0	1997	Spatiotemporal ESR-CT study on the metabolism of spin-labeled polysaccharide in a mouse.	Polysaccharides	62-76	esterase 5 regulator	Mus musculus	15-18
9300139-1	1997	A spatiotemporal ESR-CT study, rapid three dimensional ESR imaging by which distribution and metabolism of radicals in a small region in a living body can be followed, was carried out by intravenously administering spin-labeled polysaccharides to mice.	Polysaccharides	228-243	esterase 5 regulator	Mus musculus	17-20
9300139-1	1997	A spatiotemporal ESR-CT study, rapid three dimensional ESR imaging by which distribution and metabolism of radicals in a small region in a living body can be followed, was carried out by intravenously administering spin-labeled polysaccharides to mice.	Polysaccharides	228-243	esterase 5 regulator	Mus musculus	55-58
9218574-9	1997	Tests of mammary carcinoma cells from freshly excised tumors demonstrated that they also bore sufficient amounts of opsonic C3 for cytotoxic recognition by NK cells bearing polysaccharide-primed CR3, whereas they were largely resistant to NK cells bearing unprimed CR3.	Polysaccharides	173-187	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	195-198
9266683-1	1997	The ATP-dependent protease Lon (La) of Escherichia coli degrades abnormal proteins and is involved in the regulation of capsular polysaccharide synthesis.	Polysaccharides	129-143	putative ATP-dependent Lon protease	Escherichia coli	27-30
9218616-5	1997	PPME (yeast polyphosphomonoester core polysaccharide), a complex carbohydrate that mimics the natural L-selectin ligand, also induced potent intercellular adhesion.	Polysaccharides	38-52	selectin, lymphocyte	Mus musculus	102-112
9274022-3	1997	Two principal families of cytoplasmic-membrane transport systems appear to drive polysaccharide export: polysaccharide-specific transport (PST) systems and ATP-binding cassette-2 (ABC-2) systems.	Polysaccharides	81-95	ATP binding cassette subfamily A member 2	Homo sapiens	156-178
9274022-3	1997	Two principal families of cytoplasmic-membrane transport systems appear to drive polysaccharide export: polysaccharide-specific transport (PST) systems and ATP-binding cassette-2 (ABC-2) systems.	Polysaccharides	81-95	ATP binding cassette subfamily A member 2	Homo sapiens	180-185
9218427-3	1997	These polysaccharides potentiate the biological activity of TGF-beta1 (but not the other isoforms), whereas a low sulfated mucosal heparan sulfate fails to do so.	Polysaccharides	6-21	transforming growth factor beta 1	Homo sapiens	60-69
9218427-7	1997	A model is proposed in which polysaccharide binding occurs at two distinct sites on the TGF-beta dimer.	Polysaccharides	29-43	transforming growth factor beta 1	Homo sapiens	88-96
9250674-7	1997	A more detailed analysis of the conformations allows potential recognition epitopes on the glycans to be identified and can form the basis for understanding the specificity of the glucosidases and chaperones (such as calnexin) that recognize these glycans, with implications for their mechanisms of action.	Polysaccharides	91-98	calnexin	Cricetulus griseus	217-225
9250674-7	1997	A more detailed analysis of the conformations allows potential recognition epitopes on the glycans to be identified and can form the basis for understanding the specificity of the glucosidases and chaperones (such as calnexin) that recognize these glycans, with implications for their mechanisms of action.	Polysaccharides	248-255	calnexin	Cricetulus griseus	217-225
9218574-10	1997	This study demonstrates the potential utility of using naturally occurring opsonic C3 on tumor cells for specific immunotherapeutic targeting by NK cells and phagocytes bearing polysaccharide-primed CR3.	Polysaccharides	177-191	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	199-202
11902728-0	1997	Molecular organization of the genes required for the synthesis of type 1 capsular polysaccharide of Streptococcus pneumoniae: formation of binary encapsulated pneumococci and identification of cryptic dTDP-rhamnose biosynthesis genes.	Polysaccharides	82-96	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	201-205
9204884-6	1997	Nonetheless, anti-RHL-2/3 IgG reduced the binding of 125I-Lf to hepatocytes at 4 degrees C. Exoglycosidases were used to remove terminally-exposed N-acetylneuraminyl, alpha- and beta-galactosyl, and N-acetylhexosaminyl sugars from human and bovine Lf glycans, and lectin blotting confirmed that glycosidase-treated Lfs lacked detectable terminal galactosyl sugars.	Polysaccharides	251-258	asialoglycoprotein receptor 2	Rattus norvegicus	18-23
9249953-0	1997	The structure of the capsular polysaccharide from Klebsiella type 52, using the computerised approach CASPER and NMR spectroscopy.	Polysaccharides	30-44	CASP8 and FADD like apoptosis regulator	Homo sapiens	102-108
9249953-1	1997	The structure of the capsular polysaccharide from Klebsiella type 52 has been elucidated using an improved and extended version of the computerised approach CASPER and NMR spectroscopy as principal methods.	Polysaccharides	30-44	CASP8 and FADD like apoptosis regulator	Homo sapiens	157-163
9254046-6	1997	Sites which are naturally occupied by high-mannose glycans (Asn233 and Asn545) are substituted essentially by the same type of N-glycans in the recombinant counterpart, and the site Asn476,which carries sialylated complex type chains in the natural glycoprotein, is substituted by short, truncated, partially fucosylated chains in Mamestra brassicae-expressed bovine lactoferrin.	Polysaccharides	51-58	lactotransferrin	Bos taurus	367-378
9247192-2	1997	Presented evidences suggest that cytokeratins are bound in vitro by mammalian galectin-3 and the galectins from the sponge Geodia cydonium via their type II carbohydrate recognition domains, whose highest binding affinity is directed towards terminal alpha-N-acetylgalactosamine-bearing glycans with the general sequence GalNAcalpha1-3Gal(NAc)beta.	Polysaccharides	287-294	galectin 3	Homo sapiens	78-88
9200697-0	1997	Structure of glycan moieties responsible for the extended circulatory life time of fetal bovine serum acetylcholinesterase and equine serum butyrylcholinesterase.	Polysaccharides	13-19	acetylcholinesterase	Mus musculus	102-122
9184825-3	1997	Our previous work demonstrated further that an enzymatically synthetized tetravalent sLex glycan of a branched polylactosamine backbone is a highly efficient inhibitor of L-selectin-dependent lymphocyte adhesion to graft endothelium.	Polysaccharides	90-96	selectin L	Homo sapiens	171-181
9177202-5	1997	We examined the reactivity of Di-OVA to PNGase HO and found that this enzyme site-specifically cleaved off the glycan chain at Asn-311 to convert Di-OVA into the mono-N-glycosylated form (CHO-Asn-292/Asp-311).	Polysaccharides	111-117	N-glycanase 1	Homo sapiens	40-46
9184838-6	1997	The isoelectric point of ACE, as, determined by isoelectric focusing, increased from 4.5-4.8 to 5.0-5.3 after either endoglycosidase F2 or neuraminidase digestion, but still with microheterogeneities which thus did not seem to be related to ACE glycans.	Polysaccharides	245-252	angiotensin-converting enzyme	Sus scrofa	25-28
9184838-9	1997	Thus, ACE glycans have no drastic effects on structural and biological properties of the protein, but they may have a functional role on intracellular targeting of both secreted and membrane-bound ACE isoforms, also for the protection of the soluble plasma form against hepatic lectins and the maintenance of its hydrosolubility.	Polysaccharides	10-17	angiotensin-converting enzyme	Sus scrofa	6-9
9184838-9	1997	Thus, ACE glycans have no drastic effects on structural and biological properties of the protein, but they may have a functional role on intracellular targeting of both secreted and membrane-bound ACE isoforms, also for the protection of the soluble plasma form against hepatic lectins and the maintenance of its hydrosolubility.	Polysaccharides	10-17	angiotensin-converting enzyme	Sus scrofa	197-200
9209485-0	1997	L-selectin ligands in rat high endothelium: multivalent sialyl Lewis x glycans are high-affinity inhibitors of lymphocyte adhesion.	Polysaccharides	71-78	selectin L	Rattus norvegicus	0-10
9209485-9	1997	Furthermore, we suggest that L-selectin acts as an oligomer on the lymphocyte surface as it binds multivalent sLex glycans.	Polysaccharides	115-122	selectin L	Rattus norvegicus	29-39
9133639-4	1997	The glycan moiety of SGP, which was liberated by PNGase digestion, was studied for the chemical structure by HPLC mapping with p-aminobenzoic ethylester-derivatization, sugar composition analysis, 1H nuclear magnetic resonance and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry and the glycomoiety was found to be an N-linked disialyl-biantennary glycan.	Polysaccharides	4-10	N-glycanase 1	Homo sapiens	49-55
9164964-4	1997	In the present study, mAb-induced ligation of Leu-13 was shown to rapidly down-regulate L-selectin surface density on normal and malignant human lymphocytes, and to markedly inhibit L-selectin-mediated adhesion of lymphocytes to soluble carbohydrate ligands (i.e., PPME, phosphomonoester core polysaccharide) and to lymph node high endothelial venules.	Polysaccharides	293-307	interferon induced transmembrane protein 1	Homo sapiens	46-52
9164964-4	1997	In the present study, mAb-induced ligation of Leu-13 was shown to rapidly down-regulate L-selectin surface density on normal and malignant human lymphocytes, and to markedly inhibit L-selectin-mediated adhesion of lymphocytes to soluble carbohydrate ligands (i.e., PPME, phosphomonoester core polysaccharide) and to lymph node high endothelial venules.	Polysaccharides	293-307	selectin L	Homo sapiens	182-192
9239521-5	1997	PSK, a protein-bound polysaccharide, is a biological response modifier that is clinically used for the treatment of cancer patients in Japan.	Polysaccharides	21-35	TAO kinase 2	Homo sapiens	0-3
9414470-3	1997	The endometrial cell surface mucin MUC1 may play a role in both steric inhibition of attachment and selective glycan display.	Polysaccharides	110-116	mucin 1, cell surface associated	Homo sapiens	35-39
9099704-0	1997	Lectin-like characteristics of recombinant human interleukin-1beta recognizing glycans of the glycosylphosphatidylinositol anchor.	Polysaccharides	79-86	interleukin 1 beta	Homo sapiens	49-66
9099704-7	1997	Since the mannose 6-phosphate diester moiety exists only in the GPI glycans on plasma membranes, it was evident that interleukin-1beta can directly interact with the mannose 6-phosphate diester component of the intact glycan of GPI anchors on plasma membranes.	Polysaccharides	68-74	interleukin 1 beta	Homo sapiens	117-134
9203333-1	1997	X-Ray fiber diffraction patterns were obtained from oriented films of sodium salts of a new uronic acid-containing polysaccharide (beijeran) both in its native, poly [--&gt;3)-alpha-D-GalA-(1--&gt;3)-beta-L-Rha-(1--&gt;3)-alpha-D-Glc-O6Ac-(1 --&gt;], and deacetylated forms.	Polysaccharides	115-129	galactosidase alpha	Homo sapiens	184-188
9178553-0	1997	Characterization of the protein and glycan moieties in different forms of bovine lactoferrin.	Polysaccharides	36-42	lactotransferrin	Bos taurus	81-92
15348755-2	1997	The polysaccharides obtained were characterized by 1H-NMR and DSC.	Polysaccharides	4-19	desmocollin 3	Homo sapiens	62-65
9128259-5	1997	Further studies using CHO-E and -P monolayers demonstrate that the first 19 amino acids of PSGL-1 are sufficient for attachment and rolling on both E- and P-selectin and suggest that a sialyl Lewis x-containing glycan at Threonine-16 is critical for this sequence of amino acids to mediate attachment to E- and P-selectin.	Polysaccharides	211-217	selectin P ligand	Homo sapiens	91-97
9137474-1	1997	Alkali-lignin, lignin sulfonate or protein-bound polysaccharide (PSK) significantly enhanced the ascorbyl radical intensity and cytotoxic activity of ascorbate, but inhibited the intracellular incorporation of [14C]ascorbic acid.	Polysaccharides	49-63	TAO kinase 2	Homo sapiens	65-68
9054419-10	1997	Inspection of a molecular model of CD59, based on the NMR solution structure of the extracellular domain and the structural data from this study, suggested several roles for the glycans, including spacing and orienting CD59 on the cell surface and protecting the molecule from proteases.	Polysaccharides	178-185	CD59 molecule (CD59 blood group)	Homo sapiens	35-39
9054419-10	1997	Inspection of a molecular model of CD59, based on the NMR solution structure of the extracellular domain and the structural data from this study, suggested several roles for the glycans, including spacing and orienting CD59 on the cell surface and protecting the molecule from proteases.	Polysaccharides	178-185	CD59 molecule (CD59 blood group)	Homo sapiens	219-223
9109416-2	1997	The influence of glycan removal on Env sensitivity to proteases was also studied.	Polysaccharides	17-23	endogenous retrovirus group K member 20	Homo sapiens	35-38
9202426-0	1997	Arylsulfatase A from human placenta possesses only high mannose-type glycans.	Polysaccharides	69-76	arylsulfatase A	Homo sapiens	0-15
9066519-5	1997	Individual IgE responses to polysaccharide antigens of A. umbrosus and C. albicans correlated among FL patients, however, no cross-reacting IgE antibodies could be shown.	Polysaccharides	28-42	immunoglobulin heavy constant epsilon	Homo sapiens	11-14
9134437-6	1997	The binding with LS-Fc was abolished in the presence of fucoidin, a sulfated polysaccharide known to inhibit L-selectin-receptor interactions.	Polysaccharides	77-91	leucine rich pentatricopeptide repeat containing	Homo sapiens	17-22
9134437-6	1997	The binding with LS-Fc was abolished in the presence of fucoidin, a sulfated polysaccharide known to inhibit L-selectin-receptor interactions.	Polysaccharides	77-91	selectin L	Homo sapiens	109-119
9202426-7	1997	The results indicated that 97% of the arylsulfatase A oligosaccharides were low molecular weight high mannose type glycans possessing up to 5 mannose residues.	Polysaccharides	115-122	arylsulfatase A	Homo sapiens	38-53
9202426-13	1997	This study, of arylsulfatase A oligosaccharides separated from the protein part, shows that all glycans of the enzyme from human placenta are of the high mannose type.	Polysaccharides	96-103	arylsulfatase A	Homo sapiens	15-30
9067581-3	1997	The functional activity of L-selectins was assessed with L-selectin ligand analogs (polyphosphomonester core polysaccharide: PPME and fucoidin).	Polysaccharides	109-123	selectin L	Homo sapiens	27-37
9045816-5	1997	Highly purified pesticin degraded murein and murein glycan strands lacking the peptide side chains to products that were similar to those obtained by lysozyme, as revealed by high-resolution high-pressure liquid chromatography.	Polysaccharides	52-58	pesticin	Yersinia pestis	16-24
9059883-6	1997	Ly-49A and C also bind some polysaccharides, and carbohydrates on class I MHC seem to be important for its binding to Ly-49.	Polysaccharides	28-43	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	0-6
9020110-7	1997	Most of these complex glycans are terminated with alpha-galactose residues, a consequence in bovine cells of the removal of terminal sialic acids by the viral neuraminidase.	Polysaccharides	22-29	neuraminidase 1	Bos taurus	159-172
9063885-6	1997	Recently developed HPLC techniques combined with enzymatic digestion and mass spectrometry have been used to assign the glycan structures on IgG, Fab, and Fc.	Polysaccharides	120-126	FA complementation group B	Homo sapiens	146-149
9063885-8	1997	Two major glycan structures are present on Fab (fucosylated digalacto-bianntenary with and without bisect) and three on Fc (fucosylated agalacto-, 1,6 arm monogalacto-, and digalacto-bianntenary).	Polysaccharides	10-16	FA complementation group B	Homo sapiens	43-46
9124386-0	1997	SP-A enhances phagocytosis of Klebsiella by interaction with capsular polysaccharides and alveolar macrophages.	Polysaccharides	70-85	surfactant protein A1	Homo sapiens	0-4
9124386-4	1997	Furthermore, binding of capsular polysaccharide of K21a to immobilized SP-A was inhibited by mannan but not by lipopolysaccharide and K2 capsular polysaccharide.	Polysaccharides	33-47	surfactant protein A1	Homo sapiens	71-75
9124386-8	1997	We conclude that SP-A increases phagocytosis of the Klebsiella by two mechanisms, one of which is by serving as an opsonin, which binds to the capsular polysaccharides of the bacteria and potentially to SP-A receptors on the macrophages, and the other by activating the macrophages, resulting in increased activity of the mannose receptor.	Polysaccharides	152-167	surfactant protein A1	Homo sapiens	17-21
9058970-4	1997	A structural analysis by 1H- and 13C-nuclear magnetic resonance and methylation indicated that SHF contained polysaccharides consisting of -4Galp1-, -4Glcp1-, and -6Glcp1- as the major residues, and Galf1- and -6Galf1- as the minor residues.	Polysaccharides	109-124	Src homology 2 domain containing F	Mus musculus	95-98
9009313-9	1997	Based on our findings, we propose that CD18 is a possible molecular target of cryptococcal polysaccharides and that binding of the polysaccharides to CD18 has the potential to inhibit leukocyte infiltration into inflammatory sites.	Polysaccharides	91-106	integrin subunit beta 2	Homo sapiens	39-43
9009313-9	1997	Based on our findings, we propose that CD18 is a possible molecular target of cryptococcal polysaccharides and that binding of the polysaccharides to CD18 has the potential to inhibit leukocyte infiltration into inflammatory sites.	Polysaccharides	131-146	integrin subunit beta 2	Homo sapiens	150-154
9020131-1	1997	Association of calnexin with newly synthesized glycoproteins involves recognition of monoglucosylated glycans, generated in the endoplasmic reticulum via initial removal of two glucose (Glc) residues from immature glycan chains by glucosidase enzymes (Glc trimming), or addition of a single Glc residue to fully trimmed glycans by glucosyltransferase enzymes (reglucosylation).	Polysaccharides	102-109	calnexin	Homo sapiens	15-23
9020131-1	1997	Association of calnexin with newly synthesized glycoproteins involves recognition of monoglucosylated glycans, generated in the endoplasmic reticulum via initial removal of two glucose (Glc) residues from immature glycan chains by glucosidase enzymes (Glc trimming), or addition of a single Glc residue to fully trimmed glycans by glucosyltransferase enzymes (reglucosylation).	Polysaccharides	102-108	calnexin	Homo sapiens	15-23
9020131-1	1997	Association of calnexin with newly synthesized glycoproteins involves recognition of monoglucosylated glycans, generated in the endoplasmic reticulum via initial removal of two glucose (Glc) residues from immature glycan chains by glucosidase enzymes (Glc trimming), or addition of a single Glc residue to fully trimmed glycans by glucosyltransferase enzymes (reglucosylation).	Polysaccharides	320-327	calnexin	Homo sapiens	15-23
9068899-1	1997	The kinetics of thrombin inhibition by heparin cofactor II (HC II) in the presence of dermatan sulphates, native (DS), or oversulphated (DSS 1 and DSS 2) and a biospecific dextran derivative substituted with carboxymethyl, carboxymethyl-benzylamide and carboxymethyl benzylamide-sulphonate functional groups (CMDBS), has been studied as a function of the sulphated polysaccharide concentration.	Polysaccharides	365-379	coagulation factor II, thrombin	Homo sapiens	16-24
9068899-5	1997	Knowing that DSS1 has a sulphur content per disaccharide of 7.8%, compared with 11.5% for DSS2, these results indicate that the polysaccharide affinity for HC II is increased only in the case of DSS 2, whereas the oversulphation increases the reactivities towards thrombin of both complexes DSS1-HC II and DSS2-HC II.	Polysaccharides	128-142	SEM1 26S proteasome subunit	Homo sapiens	13-17
9068899-5	1997	Knowing that DSS1 has a sulphur content per disaccharide of 7.8%, compared with 11.5% for DSS2, these results indicate that the polysaccharide affinity for HC II is increased only in the case of DSS 2, whereas the oversulphation increases the reactivities towards thrombin of both complexes DSS1-HC II and DSS2-HC II.	Polysaccharides	128-142	serpin family D member 1	Homo sapiens	156-161
9068899-5	1997	Knowing that DSS1 has a sulphur content per disaccharide of 7.8%, compared with 11.5% for DSS2, these results indicate that the polysaccharide affinity for HC II is increased only in the case of DSS 2, whereas the oversulphation increases the reactivities towards thrombin of both complexes DSS1-HC II and DSS2-HC II.	Polysaccharides	128-142	coagulation factor II, thrombin	Homo sapiens	264-272
9059883-6	1997	Ly-49A and C also bind some polysaccharides, and carbohydrates on class I MHC seem to be important for its binding to Ly-49.	Polysaccharides	28-43	killer cell lectin-like receptor, subfamily A	Mus musculus	0-5
9023194-7	1997	These results indicate that the gene products identified in the present study are involved in the dTDP-L-rhamnose synthesis pathway and that the pathway relates to the biosynthesis of the serotype-specific polysaccharide antigen of S. mutans.	Polysaccharides	206-220	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	98-102
9025957-2	1997	Application has been demonstrated for neutral polysaccharide polymers such as laminarin (beta-1,3; branched), curdland (beta-1,3; unbranched), pullulan (alpha-1, 6-maltotriose), glycogen (alpha-1,4-glucan), and inulin (polyfructose).	Polysaccharides	46-60	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	89-97
9059945-1	1997	BACKGROUND: alpha-Fetoprotein is a useful diagnostic marker in hepatocellular carcinoma, during which its serum level increases and its glycan structure is hyperfucosylated.	Polysaccharides	136-142	alpha fetoprotein	Homo sapiens	12-29
9066028-1	1997	In infants, vaccines consisting of a carrier protein conjugated to the bacterial capsular polysaccharide (PRP) are far more protective against Hemophilus influenzae type b (Hib) disease than unconjugated PRP.	Polysaccharides	90-104	prion protein	Homo sapiens	106-109
9033641-2	1997	administration of PSK, a protein-bound polysaccharide derived from Basidiomycetes, on the anti-tumor T-cell response in gut-associated lymphoid tissue (GALT).	Polysaccharides	39-53	TAO kinase 2	Mus musculus	18-21
10374487-5	1997	Reconbined growth hormone and astragalus polysaccharides alleviated inhibition albumin synthesis inhibition increasing albumin serum concentration in rats with peritoneal infection.	Polysaccharides	41-56	albumin	Rattus norvegicus	79-86
10374487-5	1997	Reconbined growth hormone and astragalus polysaccharides alleviated inhibition albumin synthesis inhibition increasing albumin serum concentration in rats with peritoneal infection.	Polysaccharides	41-56	albumin	Rattus norvegicus	119-126
9025957-2	1997	Application has been demonstrated for neutral polysaccharide polymers such as laminarin (beta-1,3; branched), curdland (beta-1,3; unbranched), pullulan (alpha-1, 6-maltotriose), glycogen (alpha-1,4-glucan), and inulin (polyfructose).	Polysaccharides	46-60	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	120-128
9025957-2	1997	Application has been demonstrated for neutral polysaccharide polymers such as laminarin (beta-1,3; branched), curdland (beta-1,3; unbranched), pullulan (alpha-1, 6-maltotriose), glycogen (alpha-1,4-glucan), and inulin (polyfructose).	Polysaccharides	46-60	adrenoceptor alpha 1D	Homo sapiens	153-160
9025957-2	1997	Application has been demonstrated for neutral polysaccharide polymers such as laminarin (beta-1,3; branched), curdland (beta-1,3; unbranched), pullulan (alpha-1, 6-maltotriose), glycogen (alpha-1,4-glucan), and inulin (polyfructose).	Polysaccharides	46-60	adrenoceptor alpha 1D	Homo sapiens	188-195
8995294-2	1997	Lon contributes to the regulation of several important cellular functions, including radiation resistance, cell division, filamentation, capsular polysaccharide production, lysogeny of certain bacteriophages, and proteolytic degradation of certain regulatory and abnormal proteins.	Polysaccharides	146-160	putative ATP-dependent Lon protease	Escherichia coli	0-3
26582442-3	1997	BSA-M-SC-Re, BSA-M-SC-Ra, and AP-M-SC-Re showed strong cytokine-stimulating activity in vitro, indicating that conjugates composed of inactive fragments of polysaccharides and microbeads are able to induce cytokine release from mononuclear phagocytes.	Polysaccharides	156-171	alanyl aminopeptidase, membrane	Homo sapiens	30-34
9360706-1	1997	A glycan chain analysis of the total oligosaccharide pool derived from rat liver arylsulfatase B was carried out by.	Polysaccharides	2-8	arylsulfatase B	Rattus norvegicus	81-96
9066692-3	1997	This present communication describes the testing of a glycan, PS1, obtained from the Tice substrain of BCG against the hormonal dependent human breast cancer cell line MCF-7 and the hormonally independent BT-20 line, using 5-fluorouracil (5-FU) as a positive control.	Polysaccharides	54-60	presenilin 1	Homo sapiens	62-65
9113724-1	1997	Based on monosaccharide analysis and 1H- and 13C-NMR spectroscopy, the following structure of the O-specific polysaccharide chain of Proteus vulgaris OX2 lipopolysaccharide (LPS), which defines the O2 specificity of Proteus, was established: [formula: see text] where L-QuiNAc is N-acetyl-L-quinovosamine (2-acetamido-2,6-dideoxy-L-glucose).	Polysaccharides	109-123	CD200 antigen	Mus musculus	150-153
8999907-11	1997	These results demonstrate that in CHO cells the expressed H-type alpha1,2FT does not indiscriminately fucosylate terminal galactosyl residues in complex-type N-glycans, but it favors glycans containing polylactosamine and dramatically alters their length and sialylation.	Polysaccharides	160-167	adrenoceptor alpha 1D	Homo sapiens	65-75
22358527-8	1997	Kefiran, a polysaccharide secreted from L. kafiranofasiens GKL-28 diminished the cortisol or NA influenced IFN-beta production.	Polysaccharides	11-25	interferon beta 1	Homo sapiens	107-115
9007484-0	1997	Evidence for induction of polysaccharide specific B-cell-memory in the 1st year of life: plain Haemophilus influenzae type b-PRP (Hib) boosters children primed with a tetanus-conjugate Hib-DTPa-HBV combined vaccine.	Polysaccharides	26-40	prion protein	Homo sapiens	125-128
9007484-1	1997	UNLABELLED: The lack of an adequate immune response to the major polysaccharide of the Haemophilus influenzae type b (Hib) capsule (polyribosyl ribitol phosphate) (PRP) in very young infants (&lt; 18 months) can be overcome by conjugating PRP to a T-cell dependent carrier protein.	Polysaccharides	65-79	prion protein	Homo sapiens	164-167
8981986-9	1997	V. parahaemolyticus lonS complemented E. coli lon mutants to restore UV resistance and capsular polysaccharide regulation to that of the wild type.	Polysaccharides	96-110	putative ATP-dependent Lon protease	Escherichia coli	20-23
9386990-8	1997	Third, affinity purification of heparin molecules on a KDR-derived peptide affinity column, together with capillary electrophoresis and polyacrylamide electrophoresis analysis, was used to show that the KDR-derived peptide interacts with a specific subset of polysaccharide chains contained in the unfractionated heparin.	Polysaccharides	259-273	vascular endothelial growth factor receptor 2	Cricetulus griseus	55-58
9386990-8	1997	Third, affinity purification of heparin molecules on a KDR-derived peptide affinity column, together with capillary electrophoresis and polyacrylamide electrophoresis analysis, was used to show that the KDR-derived peptide interacts with a specific subset of polysaccharide chains contained in the unfractionated heparin.	Polysaccharides	259-273	vascular endothelial growth factor receptor 2	Cricetulus griseus	203-206
8970186-0	1997	Enhancing effect of polysaccharides from an edible brown alga, Hijikia fusiforme (Hijiki), on release of tumor necrosis factor-alpha from macrophages of endotoxin-nonresponder C3H/HeJ mice.	Polysaccharides	20-35	tumor necrosis factor	Mus musculus	105-132
8955097-0	1996	Characterization of the major core structures of the alpha2--&gt;8-linked polysialic acid-containing glycan chains present in neural cell adhesion molecule in embryonic chick brains.	Polysaccharides	101-107	neural cell adhesion molecule 1	Gallus gallus	126-155
8943270-6	1996	GdS glycans are unusually fucose-rich, and the major complex-type structures are biantennary glycans with Lewisx (Galbeta1-4(Fucalpha1-3)GlcNAc) and Lewisy (Fucalpha1-2Galbeta1-4(Fucalpha1-3)GlcNAc) antennae.	Polysaccharides	4-11	progestagen associated endometrial protein	Homo sapiens	0-3
9027340-6	1996	The Asn 52 glycan on the alpha-subunit of hCG has been identified as being required for biological activity, it is, therefore, of physiological importance to determine the structure of the hormone with its carbohydrate intact.	Polysaccharides	11-17	chorionic gonadotropin subunit beta 5	Homo sapiens	42-45
8943270-6	1996	GdS glycans are unusually fucose-rich, and the major complex-type structures are biantennary glycans with Lewisx (Galbeta1-4(Fucalpha1-3)GlcNAc) and Lewisy (Fucalpha1-2Galbeta1-4(Fucalpha1-3)GlcNAc) antennae.	Polysaccharides	93-100	progestagen associated endometrial protein	Homo sapiens	0-3
8824283-11	1996	The results indicate that human nonpancreatic secretory phospholipase A2 interacts with proteoglycans via their glycosaminoglycan moiety and that the enzyme activity may be modulated by the association of the enzyme and its substrate to the sulfated polysaccharides.	Polysaccharides	250-265	phospholipase A2 group IB	Homo sapiens	56-72
8993356-7	1996	In this capacity, PspA might expand the breath of protection elicited by a vaccine composed of only a few polysaccharide-protein conjugates representing capsule types most commonly associated with infectious pneumococci.	Polysaccharides	106-120	surfactant protein A1	Homo sapiens	18-22
8955041-1	1996	A sulfated polysaccharide, curdlan sulfate (CRDS) with 1,3-beta-D-glucan as a main chain, inhibits HIV-1 infection of human peripheral blood lymphocytes (PBLs) by binding to the V3 region of gp 120.	Polysaccharides	11-25	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	191-197
8986239-5	1996	These results indicate that the microheterogeneity of serum Tf in patients with ALD may be a more complex abnormality of elongation and processing on the glycans than merely a loss of terminal sialic acids.	Polysaccharides	154-161	transferrin	Homo sapiens	60-62
9062695-0	1996	Modulation of maize roots H(+)-ATPase by sulfated polysaccharides.	Polysaccharides	50-65	ATPase	Zea mays	31-37
9062695-7	1996	It was found that in the presence of sulfated polysaccharides the ATPase became highly sensitive to K+ and Na+.	Polysaccharides	46-61	ATPase	Zea mays	66-72
8972736-6	1996	Polyvalent L-selectin ligands as soluble monoclonal antibody (MoAb) DREG-56, the cross-linked MoAb DREG-200, and the marine algal polysaccharide fucoidin induced TNF production without addition of CD2.	Polysaccharides	130-144	selectin L	Homo sapiens	11-21
8972736-6	1996	Polyvalent L-selectin ligands as soluble monoclonal antibody (MoAb) DREG-56, the cross-linked MoAb DREG-200, and the marine algal polysaccharide fucoidin induced TNF production without addition of CD2.	Polysaccharides	130-144	tumor necrosis factor	Homo sapiens	162-165
8943049-1	1996	Recent evidence indicates that newly synthesized major histocompatibility complex (MHC) class I proteins interact with calnexin, a transmembrane endoplasmic reticulum protein specific for certain glycoproteins bearing monoglucosylated glycans.	Polysaccharides	235-242	calnexin	Mus musculus	119-127
8943049-5	1996	The data demonstrate that calnexin and calreticulin chaperones assemble with distinct MHC class I assembly intermediates in the ER and show that glycan processing is functionally coupled to release of MHC class I proteins from peptide transport molecules.	Polysaccharides	145-151	calnexin	Mus musculus	26-34
8943049-5	1996	The data demonstrate that calnexin and calreticulin chaperones assemble with distinct MHC class I assembly intermediates in the ER and show that glycan processing is functionally coupled to release of MHC class I proteins from peptide transport molecules.	Polysaccharides	145-151	calreticulin	Mus musculus	39-51
8916952-7	1996	Analysis of PSGL-1-derived O-linked oligosaccharides produced in core2 transfected cells shows the presence of more elaborated glycans.	Polysaccharides	127-134	P-selectin glycoprotein ligand 1	Cricetulus griseus	12-18
8906746-1	1996	C-reactive protein (CRP) is an acute phase serum protein that binds to phosphocholine (PC) on phospholipids and polysaccharides and to protein components of chromatin and small nuclear ribonucleoproteins.	Polysaccharides	112-127	C-reactive protein	Homo sapiens	0-18
8906746-1	1996	C-reactive protein (CRP) is an acute phase serum protein that binds to phosphocholine (PC) on phospholipids and polysaccharides and to protein components of chromatin and small nuclear ribonucleoproteins.	Polysaccharides	112-127	C-reactive protein	Homo sapiens	20-23
8894309-7	1996	The oligosaccharides were cleaved from the protein backbone and the glycans from the HPA-binding glycoform of IgA1 were compared with those from normal human IgA1.	Polysaccharides	68-75	immunoglobulin heavy constant alpha 1	Homo sapiens	110-114
8894309-8	1996	IgA1 from tumour tissue appears to be associated with an HPA-binding glycan which is not present on the normal tissue-derived IgA1.	Polysaccharides	69-75	immunoglobulin heavy constant alpha 1	Homo sapiens	0-4
8810299-4	1996	Analogous to calnexin, processing of glycan chains by glucosidase enzymes was required for initial association of TCRalpha and -beta proteins with calreticulin; however, several major differences were noted regarding interaction of calnexin and calreticulin chaperones with TCR proteins.	Polysaccharides	37-43	calreticulin	Homo sapiens	245-257
8810299-4	1996	Analogous to calnexin, processing of glycan chains by glucosidase enzymes was required for initial association of TCRalpha and -beta proteins with calreticulin; however, several major differences were noted regarding interaction of calnexin and calreticulin chaperones with TCR proteins.	Polysaccharides	37-43	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	114-117
8810299-4	1996	Analogous to calnexin, processing of glycan chains by glucosidase enzymes was required for initial association of TCRalpha and -beta proteins with calreticulin; however, several major differences were noted regarding interaction of calnexin and calreticulin chaperones with TCR proteins.	Polysaccharides	37-43	calnexin	Homo sapiens	13-21
8810299-4	1996	Analogous to calnexin, processing of glycan chains by glucosidase enzymes was required for initial association of TCRalpha and -beta proteins with calreticulin; however, several major differences were noted regarding interaction of calnexin and calreticulin chaperones with TCR proteins.	Polysaccharides	37-43	T cell receptor alpha constant	Homo sapiens	114-122
8810299-4	1996	Analogous to calnexin, processing of glycan chains by glucosidase enzymes was required for initial association of TCRalpha and -beta proteins with calreticulin; however, several major differences were noted regarding interaction of calnexin and calreticulin chaperones with TCR proteins.	Polysaccharides	37-43	calreticulin	Homo sapiens	147-159
8928251-3	1996	Mucin is composed of a central peptide core with polysaccharide chains arranged radially from the core ("bottle brushappearance").	Polysaccharides	49-63	LOC100508689	Homo sapiens	0-5
8916420-3	1996	The glycan micro-heterogeneity of natural human IFN-gamma was characterized by matrix-assisted laser desorption/ionization mass spectrometry (MALDI/MS) combined with glycosidase digestion.	Polysaccharides	4-10	interferon gamma	Homo sapiens	48-57
8916422-5	1996	The method is illustrated by the analysis of isolated glycans and complex mixtures derived from chicken ovalbumin and human immunoglobulin G.	Polysaccharides	54-61	ovalbumin (SERPINB14)	Gallus gallus	104-113
8855295-4	1996	Preincubation of J774 cells with the LPG glycans 4-18 h before stimulation with interferon gamma resulted in a significant reduction in the expression of iNOS mRNA and of NO synthesis, compared with cells preincubated with culture medium alone.	Polysaccharides	41-48	nitric oxide synthase 2, inducible	Mus musculus	154-158
8889024-3	1996	A major obstacle for the use of GUS, however, is its rapid glycan-specific hepatic clearance.	Polysaccharides	59-65	glucuronidase beta	Homo sapiens	32-35
8917403-6	1996	On the other hand, natural lignified materials, protein-bound polysaccharide (PSK) and positively-charged glucans enhanced the ascorbyl radical intensity.	Polysaccharides	62-76	TAO kinase 2	Homo sapiens	78-81
8917416-1	1996	ESR spectroscopy revealed that high molecular weight natural substances, such as protein-bound polysaccharide PSK, alkali-lignin and lignin sulfonate, significantly enhanced the ascorbyl radical intensity derived from sodium ascorbate or ascorbic acid in culture medium.	Polysaccharides	95-109	TAO kinase 2	Homo sapiens	110-113
8805617-2	1996	Two predominant pathways are defined that require the concerted action of multivalent membrane Ig cross-linking by the polysaccharide Ag with 1) various B cell-activating moieties contained within the bacterial pathogen and/or 2) cytokines, such as IFN-gamma and granulocyte-macrophage colony-stimulating factor produced by NK cells and macrophages, that become activated in a T cell-independent manner during bacterial infection.	Polysaccharides	119-133	interferon gamma	Homo sapiens	249-311
8760376-5	1996	The present study shows that the interaction between fibroblast HS, metabolically labelled with [3H]glucosamine, and the C-terminal heparin-binding domain of human plasma fibronectin (HEPII), is determined by distinct regions of the polysaccharide chain.	Polysaccharides	233-247	fibronectin 1	Homo sapiens	171-182
8703486-1	1996	The interaction of alginate from Pseudomonas aeruginosa ATCC 39324 with human leukocyte elastase was studied by determining the effects of the polysaccharide on the amidolytic activity of the enzyme toward a range of synthetic peptide substrates of different length.	Polysaccharides	143-157	elastase, neutrophil expressed	Homo sapiens	78-96
8961512-1	1996	Haemophilus influenzae type b (Hib) capsular polysaccharide (PS) conjugated to tetanus toxoid (PRP-T) was given at 4 and 6 months of age and anti-Hib PS antibody response to the first and second dose of PRP-T was compared in groups that received diphtheria-tetanus-pertussis (DTP) vaccine either simultaneously with PRP-T (34 infants) or separately at 3, 4 and 5 months of age (49 infants).	Polysaccharides	45-59	prion protein	Homo sapiens	95-98
8961512-1	1996	Haemophilus influenzae type b (Hib) capsular polysaccharide (PS) conjugated to tetanus toxoid (PRP-T) was given at 4 and 6 months of age and anti-Hib PS antibody response to the first and second dose of PRP-T was compared in groups that received diphtheria-tetanus-pertussis (DTP) vaccine either simultaneously with PRP-T (34 infants) or separately at 3, 4 and 5 months of age (49 infants).	Polysaccharides	61-63	prion protein	Homo sapiens	95-98
8702529-7	1996	CD43 lacks the fucosylated glycans found on PSGL-1 and is enriched for the nonfucosylated, disialylated core-2 hexasaccharide.	Polysaccharides	27-34	sialophorin	Homo sapiens	0-4
8768520-2	1996	MANB and MANC, which belong to glycosyl hydrolase family 26, hydrolyse several forms of mannan but do not attack the other major plant structural polysaccharides.	Polysaccharides	146-161	mannosidase alpha class 2B member 1	Homo sapiens	0-4
8757810-6	1996	The major capsular polysaccharide, glucuronoxylomannan, stimulated release of tumor necrosis factor alpha, IL-1beta, and IL-8 in a dose-dependent fashion.	Polysaccharides	19-33	tumor necrosis factor	Homo sapiens	78-105
8757810-6	1996	The major capsular polysaccharide, glucuronoxylomannan, stimulated release of tumor necrosis factor alpha, IL-1beta, and IL-8 in a dose-dependent fashion.	Polysaccharides	19-33	interleukin 1 beta	Homo sapiens	107-115
8757810-6	1996	The major capsular polysaccharide, glucuronoxylomannan, stimulated release of tumor necrosis factor alpha, IL-1beta, and IL-8 in a dose-dependent fashion.	Polysaccharides	19-33	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
8764057-6	1996	The data indicate that eight to nine of the predicted N-linked oligosaccharide sites on gC1(457t) are occupied by glycans of approximately 1,000 Da.	Polysaccharides	114-121	solute carrier family 25 member 22	Homo sapiens	88-91
8865311-8	1996	All the polysaccharides except PBGA11 induced the production of interferon-gamma in the presence of concanavalin A.	Polysaccharides	8-23	interferon gamma	Mus musculus	64-80
8922278-2	1996	The enzymes specifically hydrolyze beta-1,4 glycosyl bonds that are adjacent to beta-1,3 linkages in beta-glucan, a linear polysaccharide containing these bonds in an approximate ratio of 2.5:1.	Polysaccharides	123-137	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	35-43
9002873-1	1996	To enhance the immunogenicity of capsular-like serotype b-specific polysaccharide antigen (SPA) of Actinobacillus actinomycetemcomitans, the purified antigen was coupled with bovine serum albumin via an adipic acid hydrazide functional group.	Polysaccharides	67-81	surfactant associated protein A1	Mus musculus	91-94
8688417-2	1996	The glycan important for full biological activity of hCG, namely, that at Asn 52, appears to extend into solution both in the isolated alpha subunit and in complex with the beta subunit.	Polysaccharides	4-10	chorionic gonadotropin subunit beta 5	Homo sapiens	53-56
8688417-3	1996	The disposition of this glycan with respect to the protein backbone suggests that glycosylation maintains full biological activity of hCG either by interacting with a lectin-like region of the hCG receptor or by reducing the affinity of the hormone for the hCG receptor and preventing its down-regulation.	Polysaccharides	24-30	chorionic gonadotropin subunit beta 5	Homo sapiens	134-137
8688417-3	1996	The disposition of this glycan with respect to the protein backbone suggests that glycosylation maintains full biological activity of hCG either by interacting with a lectin-like region of the hCG receptor or by reducing the affinity of the hormone for the hCG receptor and preventing its down-regulation.	Polysaccharides	24-30	chorionic gonadotropin subunit beta 5	Homo sapiens	193-196
8688417-3	1996	The disposition of this glycan with respect to the protein backbone suggests that glycosylation maintains full biological activity of hCG either by interacting with a lectin-like region of the hCG receptor or by reducing the affinity of the hormone for the hCG receptor and preventing its down-regulation.	Polysaccharides	24-30	chorionic gonadotropin subunit beta 5	Homo sapiens	193-196
8922278-2	1996	The enzymes specifically hydrolyze beta-1,4 glycosyl bonds that are adjacent to beta-1,3 linkages in beta-glucan, a linear polysaccharide containing these bonds in an approximate ratio of 2.5:1.	Polysaccharides	123-137	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	80-88
8698522-1	1996	In this study, we demonstrated that purified capsular polysaccharide of Cryptococcus neoformans is a potent inducer of interleukin-10 (IL-10) secretion by human monocytes.	Polysaccharides	54-68	interleukin 10	Homo sapiens	135-140
8695912-7	1996	The polysaccharide fragment consisted of an alpha 1--&gt;6 linked mannan main chain to which various sugars, namely Glc, Man, and Rha were attached through alpha 1--&gt;3 (or 2) linkages.	Polysaccharides	4-18	adrenoceptor alpha 1D	Homo sapiens	44-51
8662762-5	1996	PGRP seemed to require peptidoglycan as a possible ligand to keep its glycan portion consisting of at least two or more of the repeating unit.	Polysaccharides	30-36	peptidoglycan recognition protein	Bombyx mori	0-4
8687384-5	1996	The presence on Bowes t-PA of glycans associated primarily with the nervous system is consistent with its expression in a cell line of neuroectodermal origin.	Polysaccharides	30-37	chromosome 20 open reading frame 181	Homo sapiens	22-26
8695912-7	1996	The polysaccharide fragment consisted of an alpha 1--&gt;6 linked mannan main chain to which various sugars, namely Glc, Man, and Rha were attached through alpha 1--&gt;3 (or 2) linkages.	Polysaccharides	4-18	adrenoceptor alpha 1D	Homo sapiens	156-163
8639862-5	1996	The adhesion of sickle RBCs to immobilized TSP was inhibited by the anionic polysaccharides high molecular weight (MW) dextran sulfate and chondroitin sulfate A, but not other anionic polysaccharides of similar structure and/or charge density.	Polysaccharides	76-91	thrombospondin 1	Homo sapiens	43-46
8639862-5	1996	The adhesion of sickle RBCs to immobilized TSP was inhibited by the anionic polysaccharides high molecular weight (MW) dextran sulfate and chondroitin sulfate A, but not other anionic polysaccharides of similar structure and/or charge density.	Polysaccharides	184-199	thrombospondin 1	Homo sapiens	43-46
8609224-0	1996	Cryptococcal polysaccharides induce L-selectin shedding and tumor necrosis factor receptor loss from the surface of human neutrophils.	Polysaccharides	13-28	selectin L	Homo sapiens	36-46
8675189-7	1996	The increased synthesis of hyaluronan by HSC and the failure of LEC to catabolize the polysaccharide resulted in elevated hyaluronan concentrations in the blood.	Polysaccharides	86-100	C-C motif chemokine ligand 16	Homo sapiens	64-67
8617950-4	1996	Allotypes encoded by the HLA-A and -B loci have two predominant glycan structures that were almost exclusively di-sialylated.	Polysaccharides	64-70	major histocompatibility complex, class I, A	Homo sapiens	25-37
8617950-5	1996	In contrast, HLA-C allotypes have four glycan structures, comprising those associated with HLA-A and -B and two additional glycans.	Polysaccharides	39-45	major histocompatibility complex, class I, C	Homo sapiens	13-18
8617950-5	1996	In contrast, HLA-C allotypes have four glycan structures, comprising those associated with HLA-A and -B and two additional glycans.	Polysaccharides	39-45	major histocompatibility complex, class I, A	Homo sapiens	91-103
8617950-5	1996	In contrast, HLA-C allotypes have four glycan structures, comprising those associated with HLA-A and -B and two additional glycans.	Polysaccharides	123-130	major histocompatibility complex, class I, C	Homo sapiens	13-18
8685120-2	1996	OBJECTIVES: Three alpha 1-antichymotrypsin (alpha 1-ACT) glycans have been identified.	Polysaccharides	57-64	serpin family A member 3	Homo sapiens	18-42
8685120-2	1996	OBJECTIVES: Three alpha 1-antichymotrypsin (alpha 1-ACT) glycans have been identified.	Polysaccharides	57-64	serpin family A member 3	Homo sapiens	44-55
8722088-1	1996	A high yield of extracellular polysaccharide (ECP) was obtained from callus cultures of tuberose (Polianthes tuberosa), which could be separated into an unadsorbed and two acidic fractions (TPS-1, -2) by ion-exchange column chromatography.	Polysaccharides	30-44	tryptase alpha/beta 1	Homo sapiens	190-195
8722088-3	1996	Of the three fractions, the amount of TPS-1 accounted for over 60% of total yield of ECP, which was a predominant polysaccharide consisting of arabinose (Ara), mannose (Man) and galactose (Gal) as major neutral monosaccharides.	Polysaccharides	114-128	tryptase alpha/beta 1	Homo sapiens	38-43
9206247-4	1996	The results demonstrated that, when combined with rIL-2 in a certain concentration, all three kinds of polysaccharides could enhance the LAK activity by 42%-56.9%, and reduce the dose of rIL-2 by 50% (P &lt; 0.05-0.01).	Polysaccharides	103-118	interleukin 2	Rattus norvegicus	50-55
9206247-4	1996	The results demonstrated that, when combined with rIL-2 in a certain concentration, all three kinds of polysaccharides could enhance the LAK activity by 42%-56.9%, and reduce the dose of rIL-2 by 50% (P &lt; 0.05-0.01).	Polysaccharides	103-118	interleukin 2	Rattus norvegicus	187-192
8641764-0	1996	Glycans of bovine lactoferrin function as receptors for the type 1 fimbrial lectin of Escherichia coli.	Polysaccharides	0-7	lactotransferrin	Bos taurus	18-29
8641764-4	1996	These observations indicate that the glycans of bovine lactoferrin can serve as receptors for type 1 fimbrial lectin.	Polysaccharides	37-44	lactotransferrin	Bos taurus	55-66
8641792-2	1996	In many cases, GalE is required for the biosynthesis of extracellular polysaccharide materials such as lipopolysaccharide (LPS) and capsule.	Polysaccharides	70-84	UDP-galactose-4-epimerase	Bos taurus	15-19
8608819-1	1996	Myeloperoxidase (MPO) is an enzyme located within polymorphonuclear neutrophils capable of producing cytotoxic oxidant species that are particularly active against bacteria with polysaccharide capsules.	Polysaccharides	178-192	myeloperoxidase	Homo sapiens	0-15
8608819-1	1996	Myeloperoxidase (MPO) is an enzyme located within polymorphonuclear neutrophils capable of producing cytotoxic oxidant species that are particularly active against bacteria with polysaccharide capsules.	Polysaccharides	178-192	myeloperoxidase	Homo sapiens	17-20
8652906-2	1996	To investigate the involvement of proteoglycans on control of FGF-2 induced proliferation, polysaccharide chains were degraded by specific enzymes.	Polysaccharides	91-105	fibroblast growth factor 2	Homo sapiens	62-67
8609224-10	1996	Our results indicate that cryptococcal polysaccharides, especially GXM, can cause shedding of L-selectin from the surface of neutrophils, and this may prevent neutrophils from attaching to the endothelial cell surfaces.	Polysaccharides	39-54	selectin L	Homo sapiens	94-104
8706048-1	1996	We have elucidated the direct effects of PSK (a protein-bound polysaccharide) and OK-432 (a streptococcal preparation), both immunomodulating drugs, on the gene expression for an inducible nitric oxide synthase and on the production of nitric oxide (NO) in the RAW264.7 murine macrophage cell line.	Polysaccharides	62-76	TAO kinase 2	Mus musculus	41-44
8621641-0	1996	Calnexin associates exclusively with individual CD3 delta and T cell antigen receptor (TCR) alpha proteins containing incompletely trimmed glycans that are not assembled into multisubunit TCR complexes.	Polysaccharides	139-146	calnexin	Mus musculus	0-8
8621641-0	1996	Calnexin associates exclusively with individual CD3 delta and T cell antigen receptor (TCR) alpha proteins containing incompletely trimmed glycans that are not assembled into multisubunit TCR complexes.	Polysaccharides	139-146	T cell receptor alpha variable 6-3	Mus musculus	87-90
8621641-2	1996	Assembly and intracellular transport of nascent TCR proteins is believed to be assisted by their interaction with the molecular chaperone calnexin, which for certain molecules functions as a lectin for monoglucosylated glycans.	Polysaccharides	219-226	T cell receptor alpha variable 6-3	Mus musculus	48-51
8621641-2	1996	Assembly and intracellular transport of nascent TCR proteins is believed to be assisted by their interaction with the molecular chaperone calnexin, which for certain molecules functions as a lectin for monoglucosylated glycans.	Polysaccharides	219-226	calnexin	Mus musculus	138-146
8621641-6	1996	Interestingly, we found that removal of Glc residues from glycan chains was necessary for efficient association of calnexin with TCR alpha glycoproteins but not with CD3 delta glycoproteins.	Polysaccharides	58-64	calnexin	Mus musculus	115-123
8621641-8	1996	In addition, these data document that calnexin assembly with CD3 delta and TCR alpha glycoproteins involves both glycan-dependent and glycan-independent mechanisms.	Polysaccharides	113-119	calnexin	Mus musculus	38-46
8621641-8	1996	In addition, these data document that calnexin assembly with CD3 delta and TCR alpha glycoproteins involves both glycan-dependent and glycan-independent mechanisms.	Polysaccharides	113-119	T cell receptor alpha variable 6-3	Mus musculus	75-78
8621641-8	1996	In addition, these data document that calnexin assembly with CD3 delta and TCR alpha glycoproteins involves both glycan-dependent and glycan-independent mechanisms.	Polysaccharides	134-140	calnexin	Mus musculus	38-46
8615775-4	1996	The glycan structure is completely consistent with that obtained previously for the GPI anchor of human erythrocyte AChE except for the addition of the HexNAc substituent.	Polysaccharides	4-10	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-120
8962658-10	1996	Using semi-quantitative immunohistochemical methods we have shown that in women suffering recurrent spontaneous miscarriage, mid secretory phase levels of MUC1 core protein and mucin-associated glycans are reduced (Serle et al., Fertil.	Polysaccharides	194-201	LOC100508689	Homo sapiens	177-182
8991505-0	1996	The glycans of soybean peroxidase.	Polysaccharides	4-11	peroxidase	Glycine max	23-33
8560759-5	1996	Wild-type gp160 and gp160A123 induced comparable T cell responses to those of epitopes which with respect to the secondary structure of gp160 were distant from the deleted glycans.	Polysaccharides	172-179	glutamyl aminopeptidase	Homo sapiens	10-15
8560759-5	1996	Wild-type gp160 and gp160A123 induced comparable T cell responses to those of epitopes which with respect to the secondary structure of gp160 were distant from the deleted glycans.	Polysaccharides	172-179	glutamyl aminopeptidase	Homo sapiens	20-25
8973529-8	1996	However, the glycans evidently influence the three-dimensional conformation of gp120, since their presence increases the availability of the neutralization epitope of 2G12.	Polysaccharides	13-20	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	79-84
8570646-2	1996	It has been proposed that the binding of heparin-like polysaccharides to FGF induces a conformational change in FGF, resulting in the formation of FGF dimers or oligomers, and this biologically active form is "presented" to the FGF receptor for signal transduction.	Polysaccharides	54-69	fibroblast growth factor 2	Homo sapiens	73-76
8570646-2	1996	It has been proposed that the binding of heparin-like polysaccharides to FGF induces a conformational change in FGF, resulting in the formation of FGF dimers or oligomers, and this biologically active form is "presented" to the FGF receptor for signal transduction.	Polysaccharides	54-69	fibroblast growth factor 2	Homo sapiens	112-115
8570646-2	1996	It has been proposed that the binding of heparin-like polysaccharides to FGF induces a conformational change in FGF, resulting in the formation of FGF dimers or oligomers, and this biologically active form is "presented" to the FGF receptor for signal transduction.	Polysaccharides	54-69	fibroblast growth factor 2	Homo sapiens	112-115
8570646-2	1996	It has been proposed that the binding of heparin-like polysaccharides to FGF induces a conformational change in FGF, resulting in the formation of FGF dimers or oligomers, and this biologically active form is "presented" to the FGF receptor for signal transduction.	Polysaccharides	54-69	fibroblast growth factor 2	Homo sapiens	112-115
8570646-4	1996	As a consequence, FGF-2 monomers are oriented for binding to heparin-like polysaccharides.	Polysaccharides	74-89	fibroblast growth factor 2	Homo sapiens	18-23
8570646-5	1996	We also show that heparin-like polysaccharides can readily bind to self-associated FGF-2 without causing a conformational change in FGF-2 or disrupting the FGF-2 self-association, but that the bound polysaccharides only additionally stabilize the FGF-2 self-association.	Polysaccharides	31-46	fibroblast growth factor 2	Homo sapiens	83-88
8542135-1	1996	The polysaccharide fucoidin, a homopolymer of sulfated L-fucose, is known, by interfering with the function of L-selectin, to inhibit leukocyte rolling, which is an early and essential step in the process of leukocyte extravasation into inflamed sites.	Polysaccharides	4-18	L-selectin	Oryctolagus cuniculus	111-121
8765297-1	1996	The natural substrate of lysozyme is the rigid layer of bacterial cell walls, the murein (peptidoglycan), which is a gigantic polymer of (GlcNAc-MurNAc)n polysaccharide strands crosslinked through short peptide bridges at the lactyl groups of the muramic acid residues.	Polysaccharides	154-168	lysozyme	Homo sapiens	25-33
8991511-0	1996	Synthesis of a tetravalent sialyl Lewis x glycan, a high-affinity inhibitor of L-selectin-mediated lymphocyte binding to endothelium.	Polysaccharides	42-48	selectin L	Rattus norvegicus	79-89
7499841-8	1995	These data suggest that bacteria may induce Ag-specific humoral immunity through the action of bacterial polysaccharides that mediate an Ag-specific multivalent mIg signal, in concert with bacterial lipoproteins that deliver ancillary signals, without a requirement for recruitment of non-B cell types.	Polysaccharides	105-120	chemokine (C-X-C motif) ligand 9	Mus musculus	161-164
8830763-0	1996	Antimetastatic effect of PSK, a protein-bound polysaccharide, against the B16-BL6 mouse melanoma.	Polysaccharides	46-60	TAO kinase 2	Mus musculus	25-28
8950359-6	1996	The glycan present on in vivo-derived PSMA from tumor tissue or serum was found to be primarily N-linked complex type.	Polysaccharides	4-10	folate hydrolase 1	Homo sapiens	38-42
8537687-4	1996	Of note, among persons receiving polysaccharide vaccine, antibody GMTs in HIV-uninfected and -infected persons with CD4 lymphocytes &gt; or = 500/microL were similar.	Polysaccharides	33-47	CD4 molecule	Homo sapiens	116-119
8748149-1	1995	We present kinetic studies on the enzymatic transfer of several synthetic sialic acid analogues, modified at C-5, to distinct glycoprotein glycans by sialyltransferases differing in acceptor- and linkage-specificity.	Polysaccharides	139-146	complement C5	Rattus norvegicus	109-112
8787777-3	1995	An acidic polysaccharide (TAP) was isolated from a hot-water extract of the fruiting bodies of Tremella aurantia.	Polysaccharides	10-24	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	26-29
8536711-11	1995	Besides the multivalency, also the Gal beta 1-3GalNAc-ol sequence of the O-glycosidic core appeared to increase the affinity of the glycan to L-selectin.	Polysaccharides	132-138	selectin L	Rattus norvegicus	142-152
8526907-5	1995	Conceivably, the differential expression of L2- and HNK-1 type glycans could have a role in development.	Polysaccharides	63-70	beta-1,3-glucuronyltransferase 1	Homo sapiens	52-57
7585950-1	1995	P-selectin binding to neutrophils requires a specific protein, P-selectin glycoprotein ligand 1 (PSGL-1), as well as sialyl-Lewis X (sLex) glycan determinants.	Polysaccharides	139-145	selectin P	Homo sapiens	0-10
7591110-1	1995	Serotype b-specific polysaccharide antigen (SPA) of Actinobacillus actinomycetemcomitans Y4 consists of D-fucose and L-rhamnose.	Polysaccharides	20-34	surfactant protein A2	Homo sapiens	44-47
7500048-5	1995	To examine this issue, we have directly explored the binding of calnexin to both Ii truncation mutants lacking the typical sites of N-glycosylation or Ii produced in cells treated with tunicamycin to prevent glycan addition.	Polysaccharides	208-214	calnexin	Mus musculus	64-72
7592804-2	1995	It specifically attaches to core glycans from which two glucoses have been removed by glucosidases I and II.	Polysaccharides	33-40	mannosyl-oligosaccharide glucosidase	Homo sapiens	86-107
7592804-7	1995	It was concluded that glycans are crucial for calnexin association and that the vast majority of substrate proteins are therefore glycoproteins.	Polysaccharides	22-29	calnexin	Homo sapiens	46-54
7499436-1	1995	Recent evidence indicates that efficient expression of major histocompatibility complex (MHC) complexes requires their interaction with the resident endoplasmic reticulum (ER) chaperone calnexin, which for certain proteins functions as a lectin specific for monoglucosylated glycans.	Polysaccharides	275-282	calnexin	Homo sapiens	186-194
8749202-2	1995	Antibodies to pneumococcal pneumolysin were detected in 84% and to capsular polysaccharides in 50% of the MEF samples.	Polysaccharides	76-91	E74 like ETS transcription factor 4	Homo sapiens	106-109
8749202-8	1995	On the contrary, IgG class antibodies to capsular polysaccharides, most likely serum-derived, were detected less often in MEF samples positive for pneumococcus than for other bacteria.	Polysaccharides	50-65	E74 like ETS transcription factor 4	Homo sapiens	122-125
8817495-0	1995	Opc- and pilus-dependent interactions of meningococci with human endothelial cells: molecular mechanisms and modulation by surface polysaccharides.	Polysaccharides	131-146	adhesin Opc	Neisseria meningitidis MC58	0-3
8562269-6	1995	This strategy involves the use of inhibitors of alpha-glucosidase, an intestinal enzyme that participates in the breakdown of polysaccharides into disaccharides and monosaccharides.	Polysaccharides	126-141	sucrase-isomaltase	Homo sapiens	48-65
8584007-5	1995	The presence of regucalcin (0.25 microM) with an effective concentration completely inhibited the effect of inositol-glycan (10(-5) M) to increase (Ca(2+)-Mg2+)-ATPase activity, while the effect of dibutyryl cAMP (10(-3) M) or IP3 (10(-5) M) was not altered.	Polysaccharides	116-123	regucalcin	Rattus norvegicus	16-26
8572620-0	1995	In vitro reactivity to a protein-bound polysaccharide PSK of peripheral blood lymphocytes from patients with gastrointestinal cancer.	Polysaccharides	39-53	TAO kinase 2	Homo sapiens	54-57
8595262-4	1995	The minimal structure recognized by MeAI on the porcine mucin glycans is the O-glycan core Gal beta 1,3GalNAc-ol, whereas MeAII has a more extended site and interacts with a biantennary O-glycan possessing the terminal trisaccharide Fuc alpha 1,2 (GalNAc alpha 1,3) Gal beta 1,4.	Polysaccharides	62-69	LOC100508689	Homo sapiens	56-61
7559387-5	1995	These studies demonstrate that tyrosine sulfate on PSGL-1 functions in conjunction with sialylated and fucosylated glycans to mediate high affinity binding to P-selectin.	Polysaccharides	115-122	selectin P ligand	Homo sapiens	51-57
7559387-5	1995	These studies demonstrate that tyrosine sulfate on PSGL-1 functions in conjunction with sialylated and fucosylated glycans to mediate high affinity binding to P-selectin.	Polysaccharides	115-122	selectin P	Homo sapiens	159-169
7574682-11	1995	These results indicate that the 2127-bp cDNA encodes a functional feline L/B/K-type ALP expressed on cell surfaces via phosphatidylinositol-glycan linkage.	Polysaccharides	140-146	ATHS	Homo sapiens	84-87
8585606-4	1995	The method described does not require the removal of sialic acid residues prior to derivatization, so that treatment of glycans with N-acetyl neuraminidase provided useful and additional structural information.	Polysaccharides	120-127	neuraminidase 1	Homo sapiens	142-155
8572620-1	1995	The effect of PSK, a protein-bound polysaccharide and an immunomodulator, on lymphocytes was examined in vitro for 36 patients with gastric cancer and 26 with colorectal cancer.	Polysaccharides	35-49	TAO kinase 2	Homo sapiens	14-17
7636267-1	1995	C-Reactive protein (CRP) is an acute phase serum protein in man that binds to certain bacterial polysaccharides and to components exposed on damaged cells.	Polysaccharides	96-111	C-reactive protein	Homo sapiens	0-18
24414897-4	1995	When Fraction A-2 was treated with cetyltrimethylammonium hydroxide and chloroform/butanol (24:1, v/v), it behaved as a proteinbound polysaccharide, with a molecular mass estimated to be 154 kDa by gel filtration.	Polysaccharides	133-147	G protein-coupled receptor 162	Mus musculus	14-17
7636267-1	1995	C-Reactive protein (CRP) is an acute phase serum protein in man that binds to certain bacterial polysaccharides and to components exposed on damaged cells.	Polysaccharides	96-111	C-reactive protein	Homo sapiens	20-23
7622213-0	1995	Downregulation by cryptococcal polysaccharide of tumor necrosis factor alpha and interleukin-1 beta secretion from human monocytes.	Polysaccharides	31-45	tumor necrosis factor	Homo sapiens	49-76
7622213-0	1995	Downregulation by cryptococcal polysaccharide of tumor necrosis factor alpha and interleukin-1 beta secretion from human monocytes.	Polysaccharides	31-45	interleukin 1 beta	Homo sapiens	81-99
8589216-0	1995	Activation of antithrombin III isoforms by heparan sulphate glycosaminoglycans and other sulphated polysaccharides.	Polysaccharides	99-114	serpin family C member 1	Homo sapiens	14-30
7584619-2	1995	To study the function of the glycan residues attached exclusively to the C-terminal domain, we have constructed a plasmid allowing production of nonglycosylated human transferrin in Escherichia coli.	Polysaccharides	29-35	transferrin	Homo sapiens	167-178
7635146-11	1995	The presence of this glycan is in line with the localization of glucosidase I in the lumen of the endoplasmic reticulum, shown by immunofluorescence microscopy.	Polysaccharides	21-27	mannosyl-oligosaccharide glucosidase	Homo sapiens	64-77
7552624-6	1995	The electrophoretic mobility and membrane linkage of CEA released by serum appear to be identical to those of CEA released by bacterial phospholipase C. Because bacterial phospholipase C is known specifically to cleave the phosphoinositol (PI) glycan moiety that anchors CEA to the tumor cell surface, a mechanism of action for serum cleaving this anchor is suggested.	Polysaccharides	244-250	CEA cell adhesion molecule 3	Homo sapiens	53-56
7552624-6	1995	The electrophoretic mobility and membrane linkage of CEA released by serum appear to be identical to those of CEA released by bacterial phospholipase C. Because bacterial phospholipase C is known specifically to cleave the phosphoinositol (PI) glycan moiety that anchors CEA to the tumor cell surface, a mechanism of action for serum cleaving this anchor is suggested.	Polysaccharides	244-250	CEA cell adhesion molecule 3	Homo sapiens	110-113
7552624-6	1995	The electrophoretic mobility and membrane linkage of CEA released by serum appear to be identical to those of CEA released by bacterial phospholipase C. Because bacterial phospholipase C is known specifically to cleave the phosphoinositol (PI) glycan moiety that anchors CEA to the tumor cell surface, a mechanism of action for serum cleaving this anchor is suggested.	Polysaccharides	244-250	CEA cell adhesion molecule 3	Homo sapiens	110-113
8589216-3	1995	We characterized the ability of various sulphated polysaccharides to potentiate the rates of thrombin inhibition by the isoforms.	Polysaccharides	50-65	coagulation factor II, thrombin	Homo sapiens	93-101
7580062-0	1995	[Study on effect of polysaccharides of ginseng on peripheral blood mononuclear cell induced interleukin-2 production and activity of its receptors in vitro].	Polysaccharides	20-35	interleukin 2	Homo sapiens	92-105
7543211-8	1995	Our data suggest that the ability of rLBP, rCD14, CD14 antibodies and rBPI to modulate LPS induced TNF production is strongly dependent on the LPS polysaccharide chain length.	Polysaccharides	147-161	lipopolysaccharide binding protein	Rattus norvegicus	37-41
7543211-8	1995	Our data suggest that the ability of rLBP, rCD14, CD14 antibodies and rBPI to modulate LPS induced TNF production is strongly dependent on the LPS polysaccharide chain length.	Polysaccharides	147-161	CD14 molecule	Rattus norvegicus	43-48
7543211-8	1995	Our data suggest that the ability of rLBP, rCD14, CD14 antibodies and rBPI to modulate LPS induced TNF production is strongly dependent on the LPS polysaccharide chain length.	Polysaccharides	147-161	CD14 molecule	Rattus norvegicus	44-48
7543211-8	1995	Our data suggest that the ability of rLBP, rCD14, CD14 antibodies and rBPI to modulate LPS induced TNF production is strongly dependent on the LPS polysaccharide chain length.	Polysaccharides	147-161	bactericidal/permeability-increasing protein	Rattus norvegicus	70-74
7541354-7	1995	The possibility that several binding activities of vitronectin can be ascribed to its glycan moiety was discussed, based on the specific features of the N-linked oligosaccharides on human vitronectin revealed here.	Polysaccharides	86-92	vitronectin	Homo sapiens	51-62
7541354-7	1995	The possibility that several binding activities of vitronectin can be ascribed to its glycan moiety was discussed, based on the specific features of the N-linked oligosaccharides on human vitronectin revealed here.	Polysaccharides	86-92	vitronectin	Homo sapiens	188-199
7599985-4	1995	Based on carbohydrate and sialic acid analyses, it is proposed that transferrin contains one bi-antennary glycan chain, whereas hemopexin contains two bi-antennary and one tri-antennary glycan chains.	Polysaccharides	106-112	transferrin	Homo sapiens	68-79
7599985-4	1995	Based on carbohydrate and sialic acid analyses, it is proposed that transferrin contains one bi-antennary glycan chain, whereas hemopexin contains two bi-antennary and one tri-antennary glycan chains.	Polysaccharides	186-192	hemopexin	Homo sapiens	128-137
7585123-1	1995	A ubiquitous cell adhesion receptor, CD44, preferentially binds hyaluronan, a polysaccharide macromolecule that is present in most extracellular matrices.	Polysaccharides	78-92	CD44 antigen	Mus musculus	37-41
7579796-2	1995	Two human beta-1,6-N-acetylglucosaminyltransferases forming the core 2 O-glycan branch, C2GnT and the I antigen, IGnT, are homologous to each other in three regions of the catalytic domain (A, B, C) and their genes reside at the same locus, chromosome 9, band q21 (Bierhuizen,M.F.A., Mattei, M.-G. and Fukuda,M., Genes Dev., 7, 468-478, 1993).	Polysaccharides	73-79	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	88-93
7579796-2	1995	Two human beta-1,6-N-acetylglucosaminyltransferases forming the core 2 O-glycan branch, C2GnT and the I antigen, IGnT, are homologous to each other in three regions of the catalytic domain (A, B, C) and their genes reside at the same locus, chromosome 9, band q21 (Bierhuizen,M.F.A., Mattei, M.-G. and Fukuda,M., Genes Dev., 7, 468-478, 1993).	Polysaccharides	73-79	beta-1,4-glucuronyltransferase 1	Homo sapiens	113-117
7782780-1	1995	The role of the glycans of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) in the intracellular events of Env precursor (gp160) biosynthesis has been examined by the use of a mutant gp160 in which the cluster of conserved glycosylation sites within the gp41 domain (Asn-621, -630 and -642) has been mutated.	Polysaccharides	16-23	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	132-135
7782780-1	1995	The role of the glycans of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) in the intracellular events of Env precursor (gp160) biosynthesis has been examined by the use of a mutant gp160 in which the cluster of conserved glycosylation sites within the gp41 domain (Asn-621, -630 and -642) has been mutated.	Polysaccharides	16-23	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	147-152
7782780-7	1995	The glycan component of gp41 is, therefore, important for the efficient intracellular transport and processing of gp160.	Polysaccharides	4-10	glutamyl aminopeptidase	Homo sapiens	114-119
7782780-8	1995	gp160 lacking gp41 carbohydrates is an additional example, among few others, of a protein lacking glycans that is arrested in the Golgi rather than the ER following its biosynthesis.	Polysaccharides	98-105	glutamyl aminopeptidase	Homo sapiens	0-5
7496135-1	1995	Isoelectric focusing of iron saturated serum has been established as a convenient method for showing transferrin glycan microheterogeneity.	Polysaccharides	113-119	transferrin	Homo sapiens	101-112
7538539-2	1995	The present studies were done to learn whether defined peptides of hsp60 could function as T cell carrier epitopes for a poorly immunogenic T-independent capsular polysaccharide, the Vi Ag of Salmonella typhi.	Polysaccharides	163-177	heat shock protein family D (Hsp60) member 1	Homo sapiens	67-72
7729899-5	1995	Monospecific anti-mouse recombinant interleukin-1 alpha (rIL-1 alpha) serum completely inhibited the formation of osteoclast-like cells in the presence of A. actinomycetemcomitans Y4 capsular-like polysaccharide.	Polysaccharides	197-211	interleukin 1 alpha	Mus musculus	36-55
7774715-7	1995	Moreover, 70% of total glycans were alpha-1,6-fucosylated at the GlcNAc residue linked to asparagine.	Polysaccharides	23-30	adrenoceptor alpha 1D	Homo sapiens	36-43
7774576-9	1995	Heparin activation of FGFR-4 is the first example of a mammalian polysaccharide serving as a signaling ligand.	Polysaccharides	65-79	fibroblast growth factor receptor 4	Homo sapiens	22-28
7537252-10	1995	The results show that it is possible to evoke a local as well as a systemic antibody response against a polysaccharide by conjugating it to CTB and using an appropriate route of immunization.	Polysaccharides	104-118	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	140-143
7744850-8	1995	Thus, linear polysaccharide fragments of glycogen bound to the SR membranes are likely mediating the binding of glycogen phosphorylase b to these membranes.	Polysaccharides	13-27	glycogen phosphorylase B	Homo sapiens	112-136
7755594-0	1995	N-glycosylation of human interferon-gamma: glycans at Asn-25 are critical for protease resistance.	Polysaccharides	43-50	interferon gamma	Homo sapiens	25-41
7755594-6	1995	The glycan residues of IFN-gamma, especially at Asn-25, play an important role in protease resistance.	Polysaccharides	4-10	interferon gamma	Homo sapiens	23-32
7755594-9	1995	These results emphasize the importance of glycan residues, especially at Asn-25, in the proteolytic stability of human IFN-gamma.	Polysaccharides	42-48	interferon gamma	Homo sapiens	119-128
7736594-2	1995	We found that binding to calnexin, a membrane-bound molecular chaperone, was specific to molecules that possessed monoglucosylated core glycans.	Polysaccharides	136-143	calnexin	Canis lupus familiaris	25-33
7729899-5	1995	Monospecific anti-mouse recombinant interleukin-1 alpha (rIL-1 alpha) serum completely inhibited the formation of osteoclast-like cells in the presence of A. actinomycetemcomitans Y4 capsular-like polysaccharide.	Polysaccharides	197-211	interleukin 1 alpha	Rattus norvegicus	57-68
7729899-7	1995	IL-1 receptor antagonist significantly inhibited the osteoclast-like cell formation mediated by A. actinomycetemcomitans Y4 capsular-like polysaccharide in mouse marrow cultures.	Polysaccharides	138-152	interleukin 1 complex	Mus musculus	0-4
7729899-8	1995	The bioactive IL-1 was detected in the culture media of mouse bone marrow cells stimulated with A. actinomycetemcomitans Y4 capsular-like polysaccharide.	Polysaccharides	138-152	interleukin 1 complex	Mus musculus	14-18
7729899-9	1995	These results indicate that IL-1 alpha is involved in the mechanism of the formation of osteoclast-like cells induced by A. actinomycetemcomitans Y4 capsular-like polysaccharide.	Polysaccharides	163-177	interleukin 1 complex	Mus musculus	28-32
7729899-13	1995	Furthermore, a correlation between IL-1 alpha and prostaglandin E2 in the osteoclast recruitment induced by A. actinomycetemcomitans Y4 capsular-like polysaccharide is discussed.	Polysaccharides	150-164	interleukin 1 complex	Mus musculus	35-39
7730661-0	1995	A monoclonal antibody against Meningococcus group B polysaccharides used to immunocapture and quantify polysialylated NCAM in tissues and biological fluids.	Polysaccharides	52-67	neural cell adhesion molecule 1	Homo sapiens	118-122
7663020-7	1995	Modified core glycans from gps1 cells have normal amounts of galactose (Gal) residues, but reduced amounts of Man, consistent with a defect in a Golgi mannosyltransferase in this mutant.	Polysaccharides	14-21	G protein pathway suppressor 1	Homo sapiens	27-31
7721817-8	1995	The maximal accelerations of the two heparins in this case correlated with the inhibitor fluorescence enhancements induced by the polysaccharides, consistent with the accelerations arising from conformational activation of antithrombin.	Polysaccharides	130-145	serpin family C member 1	Homo sapiens	223-235
7737145-7	1995	The glycans contain predominantly GalNAc beta 1-4GlcNAc beta instead of Gal beta 1-4GlcNAc beta elements.	Polysaccharides	4-11	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	41-47
7717992-0	1995	Rat mammary-gland transferrin: nucleotide sequence, phylogenetic analysis and glycan structure.	Polysaccharides	78-84	transferrin	Rattus norvegicus	18-29
7717992-7	1995	Native rat milk Tf is separated into four bands on native PAGE that differ only in their sialic acid content: one biantennary glycan is present containing either no sialic acid residues or up to three.	Polysaccharides	126-132	transferrin	Rattus norvegicus	16-18
7606203-0	1995	Antimetastatic effects of PSK (Krestin), a protein-bound polysaccharide obtained from basidiomycetes: an overview.	Polysaccharides	57-71	TAO kinase 2	Mus musculus	26-29
7606203-1	1995	PSK, a protein-bound polysaccharide obtained from cultured mycelia of Coriolus versicolor in basidiomycetes, is a biological response modifier, diverse operations of which include an antitumor action.	Polysaccharides	21-35	TAO kinase 2	Mus musculus	0-3
7672883-6	1995	Since dextran sulfate inhibited the binding as well, sulfated polysaccharide-binding molecules such as Thy-1 and CD2 are likely to be involved in the binding.	Polysaccharides	62-76	Thy-1 cell surface antigen	Rattus norvegicus	103-108
7672883-6	1995	Since dextran sulfate inhibited the binding as well, sulfated polysaccharide-binding molecules such as Thy-1 and CD2 are likely to be involved in the binding.	Polysaccharides	62-76	Cd2 molecule	Rattus norvegicus	113-116
7726560-3	1995	Structural analysis of the GPI glycan of NCAM, which was purified from C2C12 myotubes after metabolic labeling with [3H]inositol, was performed by sequential exoglycosidase digestion and Wistaria floribunda agglutinin-agarose column chromatography.	Polysaccharides	31-37	neural cell adhesion molecule 1	Mus musculus	41-45
7726560-5	1995	Structural analysis of the GPI glycans of the two GPI-anchored isoforms, GPI-NCAM 135 and GPI-NCAM 150, showed the enhanced attachment of the N-acetylgalactosamine residue to the GPI glycan core of GPI-NCAM 150.	Polysaccharides	31-38	neural cell adhesion molecule 1	Mus musculus	77-81
7726560-5	1995	Structural analysis of the GPI glycans of the two GPI-anchored isoforms, GPI-NCAM 135 and GPI-NCAM 150, showed the enhanced attachment of the N-acetylgalactosamine residue to the GPI glycan core of GPI-NCAM 150.	Polysaccharides	31-38	neural cell adhesion molecule 1	Mus musculus	94-98
7726560-5	1995	Structural analysis of the GPI glycans of the two GPI-anchored isoforms, GPI-NCAM 135 and GPI-NCAM 150, showed the enhanced attachment of the N-acetylgalactosamine residue to the GPI glycan core of GPI-NCAM 150.	Polysaccharides	31-38	neural cell adhesion molecule 1	Mus musculus	94-98
7533854-10	1995	Heterogeneity in expression of conformational and glycan-dependent epitopes was also observed for the natural viral env precursor, gPr160, but not for gp120.	Polysaccharides	50-56	G protein-coupled receptor 160	Homo sapiens	131-137
7533854-10	1995	Heterogeneity in expression of conformational and glycan-dependent epitopes was also observed for the natural viral env precursor, gPr160, but not for gp120.	Polysaccharides	50-56	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	151-156
7700752-0	1995	Safety and immunogenicity of PRP-T combined with DTP: excretion of capsular polysaccharide and antibody response in the immediate post-vaccination period.	Polysaccharides	76-90	prion protein	Homo sapiens	29-32
7700752-1	1995	OBJECTIVE: To evaluate whether combining Haemophilus influenzae type b capsular polysaccharide covalently linked to tetanus toxoid (PRP-T) and diphtheria-tetanus-pertussis (DTP) in one syringe produced a vaccine that was safe and immunogenic.	Polysaccharides	80-94	prion protein	Homo sapiens	132-135
7762991-0	1995	Polysaccharide preparation PSK augments the proliferation and cytotoxicity of tumor-infiltrating lymphocytes in vitro.	Polysaccharides	0-14	TAO kinase 2	Homo sapiens	27-30
7888673-1	1995	The inhibition mechanism of a polysaccharide anticoagulant, depolymerized holothurian glycosaminoglycan (DHG), was examined by analyzing its effects on the clotting time of human plasma depleted of antithrombin III (ATIII), of heparin cofactor II (HCII), or of both heparin cofactors.	Polysaccharides	30-44	serpin family C member 1	Homo sapiens	198-214
7888673-1	1995	The inhibition mechanism of a polysaccharide anticoagulant, depolymerized holothurian glycosaminoglycan (DHG), was examined by analyzing its effects on the clotting time of human plasma depleted of antithrombin III (ATIII), of heparin cofactor II (HCII), or of both heparin cofactors.	Polysaccharides	30-44	serpin family C member 1	Homo sapiens	216-221
7888673-1	1995	The inhibition mechanism of a polysaccharide anticoagulant, depolymerized holothurian glycosaminoglycan (DHG), was examined by analyzing its effects on the clotting time of human plasma depleted of antithrombin III (ATIII), of heparin cofactor II (HCII), or of both heparin cofactors.	Polysaccharides	30-44	serpin family D member 1	Homo sapiens	227-246
7888673-1	1995	The inhibition mechanism of a polysaccharide anticoagulant, depolymerized holothurian glycosaminoglycan (DHG), was examined by analyzing its effects on the clotting time of human plasma depleted of antithrombin III (ATIII), of heparin cofactor II (HCII), or of both heparin cofactors.	Polysaccharides	30-44	serpin family D member 1	Homo sapiens	248-252
7728773-0	1995	Induction of gene expression for immunomodulating cytokines in peripheral blood mononuclear cells in response to orally administered PSK, an immunomodulating protein-bound polysaccharide.	Polysaccharides	172-186	TAO kinase 2	Homo sapiens	133-136
7728773-1	1995	The protein-bound polysaccharide extracted from a fungus, PSK, has been used as a biological response modifier in the treatment of cancer patients in Japan for over 16 years.	Polysaccharides	18-32	TAO kinase 2	Homo sapiens	58-61
7876141-8	1995	Although initiation of calnexin binding appears to depend on the presence of oligosaccharide on the substrate, removal of the glycan from calnexin-associated heavy chains by digestion with endoglycosidase H did not disrupt the interaction.	Polysaccharides	126-132	calnexin	Homo sapiens	138-146
7868903-1	1995	Ra-reactive factor (RaRF) is a serum bactericidal factor whose function seems to be to activate C in a manner similar to that of C1, but with activation triggered by binding to bacterial polysaccharides instead of to immune complexes.	Polysaccharides	187-202	mannan-binding lectin serine peptidase 1	Mus musculus	0-18
7868903-1	1995	Ra-reactive factor (RaRF) is a serum bactericidal factor whose function seems to be to activate C in a manner similar to that of C1, but with activation triggered by binding to bacterial polysaccharides instead of to immune complexes.	Polysaccharides	187-202	mannan-binding lectin serine peptidase 1	Mus musculus	20-24
7860603-10	1995	E. amylovora lon mutants had increased sensitivity to UV irradiation and elevated levels of extracellular polysaccharide, suggesting comparable roles for the Lon proteases in both E. amylovora and E. coli.	Polysaccharides	106-120	putative ATP-dependent Lon protease	Escherichia coli	13-16
7867791-5	1995	Analysis of a second transferrin preparation containing both asialo- and sialo-transferrin revealed another major glycan species derived from the sialylated transferrin variant which is galactosylated and lacks bisecting N-acetylglucosamine and fucose.	Polysaccharides	114-120	transferrin	Homo sapiens	21-32
7867791-5	1995	Analysis of a second transferrin preparation containing both asialo- and sialo-transferrin revealed another major glycan species derived from the sialylated transferrin variant which is galactosylated and lacks bisecting N-acetylglucosamine and fucose.	Polysaccharides	114-120	transferrin	Homo sapiens	79-90
7867791-5	1995	Analysis of a second transferrin preparation containing both asialo- and sialo-transferrin revealed another major glycan species derived from the sialylated transferrin variant which is galactosylated and lacks bisecting N-acetylglucosamine and fucose.	Polysaccharides	114-120	transferrin	Homo sapiens	79-90
7795416-5	1995	These findings extend our previous results on the carbohydrate-binding properties of HIV-1 envelope (Env) glycoprotein in that they demonstrate the involvement of AGP glycan moieties in the binding to rgp160/rgp120.	Polysaccharides	167-173	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	101-104
7759775-0	1995	Polysaccharide (ANK-102) from Polianthes tuberosa cells deteriorates the resistance of mice to Listeria monocytogenes infection.	Polysaccharides	0-14	progressive ankylosis	Mus musculus	16-19
7759775-1	1995	Modulatory effect on the murine self defense system by a newly discovered acidic polysaccharide (ANK-102) produced by P. tuberosa cells in liquid culture was examined.	Polysaccharides	81-95	progressive ankylosis	Mus musculus	97-100
7883015-2	1995	The glycan structures used were Man6GlcNAc2-, Man5GlcNAc2-, GlcNAcMan5GlcNAc2- and Gal2GlcNAc2Man3GlcNAc2-, the substrates for mannosidase I, GlcNAc transferase I, mannosidase II and sialyltransferase, respectively.	Polysaccharides	4-10	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	127-200
7535190-1	1995	A polysaccharide containing L-rhamnose and L-xylose was isolated from the lipopolysaccharide extracted from the cell walls of the reference strain for Stenotrophomonas (Xanthomonas) maltophilia serogroup O10.	Polysaccharides	2-16	immunoglobulin kappa variable 3D-31 (pseudogene)	Homo sapiens	204-207
7556772-1	1995	Amino-derivatives of L-selectin ligand analogs: phosphonoester core polysaccharide (PPME) and fucoidin were biotinylated with the use of biotinyl-N-succinimide ester, and these biotinylated analogs b-PPME and b-fucoidin were demonstrated as useful tools to investigate the functional activity of L-selectins in cytospin preparations obtained from healthy human donors and from patients with chronic lymphocytic leukemia (CLL).	Polysaccharides	68-82	selectin L	Homo sapiens	21-31
7653160-2	1995	Glycan chain analysis performed with the use of a Glycan Differentiation Kit showed that basic forms of arylsulfatase B from human placenta contained mostly high mannose/hybrid type glycans, with 6-O-L-fucose bound to the innermost N-acetylglucosamine residue, whereas acidic forms of the enzyme contained complex type glycans containing fucose and sialic acid.	Polysaccharides	0-6	arylsulfatase B	Homo sapiens	104-119
7653160-2	1995	Glycan chain analysis performed with the use of a Glycan Differentiation Kit showed that basic forms of arylsulfatase B from human placenta contained mostly high mannose/hybrid type glycans, with 6-O-L-fucose bound to the innermost N-acetylglucosamine residue, whereas acidic forms of the enzyme contained complex type glycans containing fucose and sialic acid.	Polysaccharides	50-56	arylsulfatase B	Homo sapiens	104-119
7653160-2	1995	Glycan chain analysis performed with the use of a Glycan Differentiation Kit showed that basic forms of arylsulfatase B from human placenta contained mostly high mannose/hybrid type glycans, with 6-O-L-fucose bound to the innermost N-acetylglucosamine residue, whereas acidic forms of the enzyme contained complex type glycans containing fucose and sialic acid.	Polysaccharides	182-189	arylsulfatase B	Homo sapiens	104-119
7653160-2	1995	Glycan chain analysis performed with the use of a Glycan Differentiation Kit showed that basic forms of arylsulfatase B from human placenta contained mostly high mannose/hybrid type glycans, with 6-O-L-fucose bound to the innermost N-acetylglucosamine residue, whereas acidic forms of the enzyme contained complex type glycans containing fucose and sialic acid.	Polysaccharides	319-326	arylsulfatase B	Homo sapiens	104-119
7858952-10	1995	Taken together, these data suggest the presence of a unique form of the membrane-bound AChE which has at least alpha-mannose and N-acetylglucosamine residues in the glycan chain.	Polysaccharides	165-171	acetylcholinesterase	Ovis aries	87-91
7806386-1	1995	Human immunoglobulin G (IgG) Fc receptor IIa (Fc gamma RIIa; CD32) is expressed on phagocytes, triggers phagocytosis, and represents the sole Fc receptor for IgG (Fc gamma R) capable of interaction with IgG2, the main IgG subclass induced in response to bacterial capsular polysaccharides.	Polysaccharides	273-288	Fc gamma receptor IIa	Homo sapiens	6-44
7806386-1	1995	Human immunoglobulin G (IgG) Fc receptor IIa (Fc gamma RIIa; CD32) is expressed on phagocytes, triggers phagocytosis, and represents the sole Fc receptor for IgG (Fc gamma R) capable of interaction with IgG2, the main IgG subclass induced in response to bacterial capsular polysaccharides.	Polysaccharides	273-288	Fc gamma receptor IIa	Homo sapiens	46-59
7806386-1	1995	Human immunoglobulin G (IgG) Fc receptor IIa (Fc gamma RIIa; CD32) is expressed on phagocytes, triggers phagocytosis, and represents the sole Fc receptor for IgG (Fc gamma R) capable of interaction with IgG2, the main IgG subclass induced in response to bacterial capsular polysaccharides.	Polysaccharides	273-288	Fc gamma receptor IIa	Homo sapiens	61-65
7829605-7	1995	The variable secretion of SHBG is hypothesized to be due to the different effects of hormones and growth factors on either the glycan moiety of SHBG or the expression of the alternatively spliced transcripts of the SHBG gene.	Polysaccharides	127-133	sex hormone binding globulin	Homo sapiens	26-30
7829605-7	1995	The variable secretion of SHBG is hypothesized to be due to the different effects of hormones and growth factors on either the glycan moiety of SHBG or the expression of the alternatively spliced transcripts of the SHBG gene.	Polysaccharides	127-133	sex hormone binding globulin	Homo sapiens	144-148
7829605-7	1995	The variable secretion of SHBG is hypothesized to be due to the different effects of hormones and growth factors on either the glycan moiety of SHBG or the expression of the alternatively spliced transcripts of the SHBG gene.	Polysaccharides	127-133	sex hormone binding globulin	Homo sapiens	144-148
7732730-3	1995	The hemicelluloses constitute an important group of polysaccharides, which are inter-linked and also linked to microfibrils of cellulose and/or pectins, the most important being: xylans, arabinoxylans, mannans, galactomannans, glucomannans, arabinogalactan II, beta-1,3-glucan and beta-1,3-beta-1,4-glucans.	Polysaccharides	52-67	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	261-269
7798688-1	1995	Passive transfer of antibody to infants born to women immunized during the third trimester of pregnancy with a Haemophilus influenzae type b (Hib) vaccine (PRP polysaccharide or Hib conjugates PRP-D or HbOC) was studied in 50 mothers and infants and 47 nonimmunized mother-infant pairs.	Polysaccharides	160-174	prion protein	Homo sapiens	156-159
7798688-7	1995	Administration of PRP conjugate vaccines to women during pregnancy resulted in higher levels of PRP antibodies in infants than did polysaccharide or no vaccine.	Polysaccharides	131-145	prion protein	Homo sapiens	18-21
7740492-7	1995	We also showed that LMWH as well as other sulphated polysaccharides can bind to HIT antibodies in the presence of PF4 and that their reactivity is dependent on the molecular weight and the sulphation grade.	Polysaccharides	52-67	platelet factor 4	Homo sapiens	114-117
7572178-1	1995	Phytolacca acinosa polysaccharides I (PAP-I), a kind of purified polysaccharides, isolated from Phytolacca acinosa Roxb was found to significantly augment the cytotoxicity of murine splenocytes and interleukin-2 (IL-2) activated splenocytes against P815 tumor cells in vitro.	Polysaccharides	19-34	annexin A5	Mus musculus	38-43
7572178-1	1995	Phytolacca acinosa polysaccharides I (PAP-I), a kind of purified polysaccharides, isolated from Phytolacca acinosa Roxb was found to significantly augment the cytotoxicity of murine splenocytes and interleukin-2 (IL-2) activated splenocytes against P815 tumor cells in vitro.	Polysaccharides	19-34	interleukin 2	Mus musculus	198-211
7572178-1	1995	Phytolacca acinosa polysaccharides I (PAP-I), a kind of purified polysaccharides, isolated from Phytolacca acinosa Roxb was found to significantly augment the cytotoxicity of murine splenocytes and interleukin-2 (IL-2) activated splenocytes against P815 tumor cells in vitro.	Polysaccharides	19-34	interleukin 2	Mus musculus	213-217
7572178-1	1995	Phytolacca acinosa polysaccharides I (PAP-I), a kind of purified polysaccharides, isolated from Phytolacca acinosa Roxb was found to significantly augment the cytotoxicity of murine splenocytes and interleukin-2 (IL-2) activated splenocytes against P815 tumor cells in vitro.	Polysaccharides	65-80	annexin A5	Mus musculus	38-43
7732730-3	1995	The hemicelluloses constitute an important group of polysaccharides, which are inter-linked and also linked to microfibrils of cellulose and/or pectins, the most important being: xylans, arabinoxylans, mannans, galactomannans, glucomannans, arabinogalactan II, beta-1,3-glucan and beta-1,3-beta-1,4-glucans.	Polysaccharides	52-67	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	281-289
7732730-3	1995	The hemicelluloses constitute an important group of polysaccharides, which are inter-linked and also linked to microfibrils of cellulose and/or pectins, the most important being: xylans, arabinoxylans, mannans, galactomannans, glucomannans, arabinogalactan II, beta-1,3-glucan and beta-1,3-beta-1,4-glucans.	Polysaccharides	52-67	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	290-298
7696855-1	1994	Citrus pectin (CP) and pH-modified citrus pectin (MCP) are highly branched and non-branched complex polysaccharides, respectively, rich in galactoside residues, capable of combining with the carbohydrate-binding domain of galectin-3.	Polysaccharides	100-115	lectin, galactose binding, soluble 3	Mus musculus	222-232
7537078-1	1994	Hydrophobized polysaccharides such as cholesterol-bearing pullulan (CHP), dextran (CHD) and mannan (CHM) effectively coat the liposomal surface.	Polysaccharides	14-29	CHM Rab escort protein	Homo sapiens	100-103
7895167-4	1994	Fucoidan, a sulfated polysaccharide, binds to Ly-49A in a calcium-dependent manner, and this binding is inhibited by monosaccharides, particularly sulfated hexoses.	Polysaccharides	21-35	killer cell lectin-like receptor, subfamily A, member 1	Mus musculus	46-52
7890120-0	1994	Characterization of human arylsulfatase A glycans.	Polysaccharides	42-49	arylsulfatase A	Homo sapiens	26-41
7890120-1	1994	Despite numerous studies on arylsulfatase A, the structure of the glycans present in each of its two subunits has not been determined.	Polysaccharides	66-73	arylsulfatase A	Homo sapiens	28-43
7890120-11	1994	The study shows that both subunits of arylsulfatase A from human placenta possess two high mannose/hybrid type glycans as major structures, with at least one 6-O-L-fucose bound to the innermost N-acetylglucosamine on each.	Polysaccharides	111-118	arylsulfatase A	Homo sapiens	38-53
7964500-1	1994	Pneumococcal surface protein A (PspA), a cell-surface protein present on all strains of pneumococci, has been shown to elicit protective antibody responses in mice in the absence of capsular polysaccharide.	Polysaccharides	191-205	surfactant associated protein A1	Mus musculus	32-36
7533044-7	1994	Furthermore, we show that the recognition of sialylated glycans on the surfaces of particular cell types leads to the selective binding of sialoadhesin to neutrophils, myelin-associated glycoprotein to neurons and CD22 to lymphocytes.	Polysaccharides	56-63	sialic acid binding Ig like lectin 1	Homo sapiens	139-151
7980452-2	1994	In order to understand the role of glycan residues in the synthesis and secretion of human IFN-gamma, both or either one of the potential N-linked glycosylation sites were mutated to Gln.	Polysaccharides	35-41	interferon gamma	Homo sapiens	91-100
7737677-4	1994	4H3.C8B was originally recovered by screening for antibody binding to Cryptococcus neoformans polysaccharide antigen and characterized as gamma 3 lambda.	Polysaccharides	94-108	complement C8 beta chain	Homo sapiens	4-7
7947925-1	1994	It has been proposed that the function of serum amyloid P component (SAP) may closely relate with its binding to polysaccharides, especially glycosaminoglycans.	Polysaccharides	113-128	amyloid P component, serum	Homo sapiens	42-67
7947925-1	1994	It has been proposed that the function of serum amyloid P component (SAP) may closely relate with its binding to polysaccharides, especially glycosaminoglycans.	Polysaccharides	113-128	amyloid P component, serum	Homo sapiens	69-72
7757423-0	1994	Feasible synthesis and biological properties of six "non-glycosamino" glycan analogues of the antithrombin III binding heparin pentasaccharide.	Polysaccharides	70-76	serpin family C member 1	Homo sapiens	94-110
7826996-2	1994	Viscous polysaccharides are known to attenuate postprandial plasma glucose and insulin responses.	Polysaccharides	8-23	insulin	Homo sapiens	79-86
7533044-7	1994	Furthermore, we show that the recognition of sialylated glycans on the surfaces of particular cell types leads to the selective binding of sialoadhesin to neutrophils, myelin-associated glycoprotein to neurons and CD22 to lymphocytes.	Polysaccharides	56-63	myelin associated glycoprotein	Homo sapiens	168-198
7533044-7	1994	Furthermore, we show that the recognition of sialylated glycans on the surfaces of particular cell types leads to the selective binding of sialoadhesin to neutrophils, myelin-associated glycoprotein to neurons and CD22 to lymphocytes.	Polysaccharides	56-63	CD22 molecule	Homo sapiens	214-218
7868297-2	1994	We investigated the properties of the pectic polysaccharide fraction of TJ-48 (F-5-2) which is most active in the proliferation of spleen cells.	Polysaccharides	45-59	MARCKS like 1	Homo sapiens	79-84
7873777-8	1994	Finally, comparison of Nod factor biosynthesis to other examples of polysaccharide or glycolipid biosynthetic pathways suggest that several key enzymes remain to be identified.	Polysaccharides	68-82	atrophin 1	Homo sapiens	23-26
7965202-0	1994	Fermentable polysaccharides that enhance fecal bile acid excretion lower plasma cholesterol and apolipoprotein E-rich HDL in rats.	Polysaccharides	12-27	apolipoprotein E	Rattus norvegicus	96-112
7897588-0	1994	In-vivo and in-vitro targeting of a murine sarcoma by gelatin microparticles loaded with a glycan (PS1).	Polysaccharides	91-97	presenilin 1	Mus musculus	99-102
7897588-1	1994	PS1, a complex polysaccharide derived from Mycobacterium bovis (Bacillus Calmette-Guerin, BCG) with considerable antitumor activity in-vivo, was loaded onto gelatin microparticles (mean diam.	Polysaccharides	15-29	presenilin 1	Mus musculus	0-3
7887019-1	1994	Human recombinant interleukin-2 can be associated and released from supramolecular biovectors (SMBVs), consisting of particles made of polymerized polysaccharides.	Polysaccharides	147-162	interleukin 2	Homo sapiens	18-31
7881169-3	1994	Based on new evidence, we propose that the ER/cytosolic mannosidase is involved in the degradation of dolichol intermediates that are not needed for protein glycosylation, whereas the soluble form of Man9-mannosidase is responsible for the degradation of glycans on defective or malfolded proteins that are specifically retained and broken down in the ER.	Polysaccharides	255-262	mannosidase alpha class 1A member 1	Homo sapiens	200-216
7929122-4	1994	Anion-exchange high performance liquid chromatography of disaccharides obtained by deaminative cleavage of the 35S-labeled polysaccharide product revealed O-35S-sulfation at C-2 of L-iduronic acid and at C-6 of D-glucosamine units.	Polysaccharides	123-137	complement component 2 (within H-2S)	Mus musculus	174-177
7929122-4	1994	Anion-exchange high performance liquid chromatography of disaccharides obtained by deaminative cleavage of the 35S-labeled polysaccharide product revealed O-35S-sulfation at C-2 of L-iduronic acid and at C-6 of D-glucosamine units.	Polysaccharides	123-137	complement component 6	Mus musculus	204-207
7863794-1	1994	PSK (Krestin) is a protein-bound polysaccharide with antitumor and immunomodulatory activity.	Polysaccharides	33-47	TAO kinase 2	Mus musculus	0-3
7535137-4	1994	Furthermore, L-929 PNGase was revealed to bind to the glycan moiety of yeast mannan by using mannan-conjugated Sepharose 4B gel as a ligand, suggesting that L-929 PNGase could serve not only as an enzyme but also as a carbohydrate recognition protein in vivo.	Polysaccharides	54-60	N-glycanase 1	Homo sapiens	19-25
7535137-4	1994	Furthermore, L-929 PNGase was revealed to bind to the glycan moiety of yeast mannan by using mannan-conjugated Sepharose 4B gel as a ligand, suggesting that L-929 PNGase could serve not only as an enzyme but also as a carbohydrate recognition protein in vivo.	Polysaccharides	54-60	N-glycanase 1	Homo sapiens	163-169
8000967-1	1994	An IgG1 monoclonal antibody generated from a mouse infected with Cryptococcus neoformans modified the course of intravenous cryptococcal infection in A/J mice by prolonging survival and reducing lung fungal burden, brain mass, and serum polysaccharide levels.	Polysaccharides	237-251	LOC105243590	Mus musculus	3-7
7881176-6	1994	The glycan structure of the transferrin secreted by the embryo hepatocytes in primary culture was marked by the presence of fucose (alpha 1-6) linked to the core N-acetylglucosamine, suggesting that expression of the fucosyltransferase activity is dependent on cell culture conditions.	Polysaccharides	4-10	asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae)	Gallus gallus	132-141
7881176-7	1994	Moreover, comparative analysis of chicken serum transferrin and ovotransferrin glycans reinforces the idea that the glycosylation of two identical polypeptide chains is organ specific.	Polysaccharides	79-86	transferrin (ovotransferrin)	Gallus gallus	64-78
7929059-7	1994	The attachment of these glycans to the polypeptide backbone via the linkage, Man alpha 1-PO4-Ser, is suggested by: 1) the finding that more than 60% of the serine residues in the polypeptide are phosphorylated and 2) the resistance of the phosphoserine residues to alkaline phosphatase digestion unless the sAP was first treated with either mild acid (to release all glycans) or jack bean alpha-mannosidase (to release neutral mannose glycans).	Polysaccharides	24-31	adrenoceptor alpha 1D	Homo sapiens	81-88
7930727-1	1994	Fc gamma RIIa (CD32) is the sole IgG Fc receptor capable of interaction with human IgG2, the main IgG subclass of bacterial capsular polysaccharides.	Polysaccharides	133-148	Fc gamma receptor IIa	Homo sapiens	0-13
7930727-1	1994	Fc gamma RIIa (CD32) is the sole IgG Fc receptor capable of interaction with human IgG2, the main IgG subclass of bacterial capsular polysaccharides.	Polysaccharides	133-148	Fc gamma receptor IIa	Homo sapiens	15-19
7967508-2	1994	These polysaccharides can interact specifically with cytokines such as basic fibroblast growth factor (bFGF).	Polysaccharides	6-21	fibroblast growth factor 2	Homo sapiens	71-101
7967508-2	1994	These polysaccharides can interact specifically with cytokines such as basic fibroblast growth factor (bFGF).	Polysaccharides	6-21	fibroblast growth factor 2	Homo sapiens	103-107
7929059-7	1994	The attachment of these glycans to the polypeptide backbone via the linkage, Man alpha 1-PO4-Ser, is suggested by: 1) the finding that more than 60% of the serine residues in the polypeptide are phosphorylated and 2) the resistance of the phosphoserine residues to alkaline phosphatase digestion unless the sAP was first treated with either mild acid (to release all glycans) or jack bean alpha-mannosidase (to release neutral mannose glycans).	Polysaccharides	24-31	SH2 domain containing 1A	Homo sapiens	307-310
7929059-7	1994	The attachment of these glycans to the polypeptide backbone via the linkage, Man alpha 1-PO4-Ser, is suggested by: 1) the finding that more than 60% of the serine residues in the polypeptide are phosphorylated and 2) the resistance of the phosphoserine residues to alkaline phosphatase digestion unless the sAP was first treated with either mild acid (to release all glycans) or jack bean alpha-mannosidase (to release neutral mannose glycans).	Polysaccharides	367-374	adrenoceptor alpha 1D	Homo sapiens	81-88
7801727-6	1994	The immunoreactivity of CCA to 1 G 10 antibody could be abolished completely by the treatment of the antigen with NaIO4 and proteinase K. These results indicated that the determinants of CCA reacted with 1 G 10 monoclonal antibody are probably both present in polysaccharide and protein part of the molecule.	Polysaccharides	260-274	fibrillin 2	Homo sapiens	24-27
7978908-8	1994	However, it is also possible that MUC-1 displays specific (e.g., glycan) recognition structures for the initial attachment of the blastocyst or that the embryo may create a specialised microenvironment in which to implant.	Polysaccharides	65-71	mucin 1, cell surface associated	Homo sapiens	34-39
7806965-3	1994	The utilization of these sites for glycan-binding and the role of each glycan chain for the catalytic function of human LPL, rat HL, and human HL was investigated.	Polysaccharides	71-77	lipoprotein lipase	Homo sapiens	120-123
7801727-6	1994	The immunoreactivity of CCA to 1 G 10 antibody could be abolished completely by the treatment of the antigen with NaIO4 and proteinase K. These results indicated that the determinants of CCA reacted with 1 G 10 monoclonal antibody are probably both present in polysaccharide and protein part of the molecule.	Polysaccharides	260-274	fibrillin 2	Homo sapiens	187-190
7812365-0	1994	Suppressive effects on cancer cell proliferation of the enhancement of superoxide dismutase (SOD) activity associated with the protein-bound polysaccharide of Coriolus versicolor QUEL.	Polysaccharides	141-155	superoxide dismutase 1	Homo sapiens	93-96
7857772-1	1994	Pertussis toxin was used to block insulin-stimulated phosphatidylinositol (PI)-glycan hydrolysis, consequent de novo synthesis of phosphatidic acid (PA) and the diacylglycerol (DAG) production that results from these two related processes in BC3H-1 myocytes.	Polysaccharides	79-85	insulin	Homo sapiens	34-41
7812365-1	1994	The protein-bound polysaccharide of Coriolus versicolor QUEL (PS-K) expresses superoxide dismutase (SOD) mimicking activity.	Polysaccharides	18-32	superoxide dismutase 1	Homo sapiens	100-103
8005664-0	1994	Induction of tumor necrosis factor alpha by the group- and type-specific polysaccharides from type III group B streptococci.	Polysaccharides	73-88	tumor necrosis factor	Rattus norvegicus	13-40
8033914-12	1994	Man9GlcNAc was hydrolysed by the purified enzyme down to a Man5GlcNAc structure, i.e. Man(alpha 1-2)Man(alpha 1-2)Man(alpha 1-3)[Man(alpha 1-6)]Man(beta 1-4) GlcNA c, which represents the Man5 oligosaccharide chain of the dolichol pathway formed in the cytosolic compartment during the biosynthesis of N-glycosylprotein glycans.	Polysaccharides	320-327	mannosidase alpha class 1A member 1	Homo sapiens	0-4
7516310-8	1994	Both peptidoglycan and the soluble glycan-teichoic acid component prepared by an enzymatic method from the same wall preparation exhibited a serum-dependent induction of TNF-alpha from monocytes, while stem peptides and disacharride peptides had only poor, if any, activity.	Polysaccharides	12-18	tumor necrosis factor	Homo sapiens	170-179
8005664-4	1994	Intracardiac injections of either polysaccharide induced dose-dependent, transient elevations in plasma TNF-alpha levels that returned to baseline values after 5 h. The group-specific antigen induced significantly higher mean peak TNF-alpha levels than the type III antigen (125 +/- 47 versus 44 +/- 15 U/ml with 70 mg/kg of body weight).	Polysaccharides	34-48	tumor necrosis factor	Rattus norvegicus	104-113
8005664-4	1994	Intracardiac injections of either polysaccharide induced dose-dependent, transient elevations in plasma TNF-alpha levels that returned to baseline values after 5 h. The group-specific antigen induced significantly higher mean peak TNF-alpha levels than the type III antigen (125 +/- 47 versus 44 +/- 15 U/ml with 70 mg/kg of body weight).	Polysaccharides	34-48	tumor necrosis factor	Rattus norvegicus	231-240
8005664-9	1994	The lethal activities of GBS polysaccharides, as well as endotoxin, were completely prevented by pretreatment of neonatal rats with the respective specific antibodies or anti-murine TNF-alpha serum.	Polysaccharides	29-44	tumor necrosis factor	Rattus norvegicus	182-191
8005664-13	1994	Type III capsular polysaccharide, however, can significantly increase the ability of GBS to induce TNF-alpha.	Polysaccharides	18-32	tumor necrosis factor	Rattus norvegicus	99-108
8005664-2	1994	This study was undertaken to investigate the ability of the type III and group-specific polysaccharides of GBS to induce TNF-alpha production and TNF-alpha-dependent lethality in neonatal rats.	Polysaccharides	88-103	tumor necrosis factor	Rattus norvegicus	121-130
8005664-2	1994	This study was undertaken to investigate the ability of the type III and group-specific polysaccharides of GBS to induce TNF-alpha production and TNF-alpha-dependent lethality in neonatal rats.	Polysaccharides	88-103	tumor necrosis factor	Rattus norvegicus	146-155
8193358-15	1994	These studies indicate that heparin and other large, highly sulfated polysaccharides bind to PF4 to form a reactive antigen on the platelet surface.	Polysaccharides	69-84	platelet factor 4	Homo sapiens	93-96
7515975-0	1994	A novel, glycan-dependent epitope in the V2 domain of human immunodeficiency virus type 1 gp120 is recognized by a highly potent, neutralizing chimpanzee monoclonal antibody.	Polysaccharides	9-15	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	90-95
8003533-1	1994	In this study we report the number and location of the glycans on PST.	Polysaccharides	55-62	sulfotransferase family 1A member 1	Homo sapiens	66-69
8080078-1	1994	The improved sensitivity and soft ionization characteristics of electrospray (ES) mass spectrometry (MS) has been applied to the glycan structures of recombinant erythropoietin (rEPO).	Polysaccharides	129-135	erythropoietin	Homo sapiens	162-176
8080078-1	1994	The improved sensitivity and soft ionization characteristics of electrospray (ES) mass spectrometry (MS) has been applied to the glycan structures of recombinant erythropoietin (rEPO).	Polysaccharides	129-135	erythropoietin	Rattus norvegicus	178-182
7813394-5	1994	Information on the structure of the glycans was revealed by the changes in the band patterns observed after the mixtures of the glycan fluorophore derivatives were treated with either of the enzymes neuraminidase or beta-galactosidase.	Polysaccharides	36-43	neuraminidase 1	Homo sapiens	199-212
7813394-5	1994	Information on the structure of the glycans was revealed by the changes in the band patterns observed after the mixtures of the glycan fluorophore derivatives were treated with either of the enzymes neuraminidase or beta-galactosidase.	Polysaccharides	36-43	galactosidase beta 1	Homo sapiens	216-234
7813394-5	1994	Information on the structure of the glycans was revealed by the changes in the band patterns observed after the mixtures of the glycan fluorophore derivatives were treated with either of the enzymes neuraminidase or beta-galactosidase.	Polysaccharides	36-42	neuraminidase 1	Homo sapiens	199-212
7813394-5	1994	Information on the structure of the glycans was revealed by the changes in the band patterns observed after the mixtures of the glycan fluorophore derivatives were treated with either of the enzymes neuraminidase or beta-galactosidase.	Polysaccharides	36-42	galactosidase beta 1	Homo sapiens	216-234
8030949-4	1994	Using scrapie-infected neuroblastoma cells to screen for such compounds in vitro, we found that the amyloid binding dye Congo red and certain sulfated glycans potently inhibited the accumulation of protease-resistant PrP in scrapie-infected cells without apparent effects on the metabolism of the normal isoform.	Polysaccharides	151-158	prion protein	Homo sapiens	217-220
8030949-5	1994	The relative potencies of the sulfated glycans corresponded with their previously determined anti-scrapie activities in vivo, suggesting that the prophylactic effects of sulfated polyanions may be due to inhibition of protease-resistant PrP accumulation.	Polysaccharides	39-46	prion protein	Homo sapiens	237-240
7910230-3	1994	We have assessed the efficacy of protein-bound polysaccharide (PSK) in addition to standard chemotherapy in patients who had undergone curative gastrectomy at 46 institutions in central Japan.	Polysaccharides	47-61	TAO kinase 2	Homo sapiens	63-66
8185704-3	1994	RESULTS: Significantly elevated frequencies and titers of antibodies to capsular polysaccharides K26, K36, and K50 were detected in sera from AS patients, compared with controls.	Polysaccharides	81-96	keratin 26	Homo sapiens	97-100
7812655-4	1994	With this in vitro system, Congo red and several sulfated polysaccharides, including heparin and pentosan polysulfate, were found to inhibit accumulation of protease-resistant PrP.	Polysaccharides	58-73	prion protein	Homo sapiens	176-179
8157651-4	1994	Using a recombinant human HGF affinity column, we have analyzed the effects of various specific chemical and enzymatic modifications/depolymerizations of HS on its affinity in order to elucidate the polysaccharide structural determinants.	Polysaccharides	199-213	hepatocyte growth factor	Homo sapiens	26-29
7812357-0	1994	Oxidative stress relief for cancer-bearing hosts by the protein-bound polysaccharide of Coriolus versicolor QUEL with SOD mimicking activity.	Polysaccharides	70-84	superoxide dismutase 1	Homo sapiens	118-121
7812357-1	1994	The protein-bound polysaccharide of Coriolus versicolor QUEL (PS-K) expresses the mimetic activity of superoxide dismutase (SOD).	Polysaccharides	18-32	superoxide dismutase 1	Homo sapiens	124-127
8011926-7	1994	The proteoglycan aggregate is thus an example for a structure where a polysaccharide forms a template for a supramolecular assembly largely stabilized by protein-protein interactions.	Polysaccharides	70-84	hyaluronan and proteoglycan link protein 1	Homo sapiens	4-16
8168940-6	1994	All three anti-Ids recognize a minor subset of antimeningococcal B polysaccharide antibodies present in serum from normal adults.	Polysaccharides	67-81	iduronate 2-sulfatase	Homo sapiens	15-18
8168940-8	1994	These 15A-associated Ids are expressed by some heterologous human antimeningococcal B polysaccharide MAbs, and they also are independently expressed by two human MAbs that are specific for either the H. influenzae b polysaccharide or the i erythrocyte antigen and that utilize the kappa I-15A V region.	Polysaccharides	86-100	iduronate 2-sulfatase	Homo sapiens	21-24
7511169-1	1994	Congo red and certain sulfated glycans are potent inhibitors of protease-resistant PrP accumulation in scrapie-infected cells.	Polysaccharides	31-38	prion protein	Mus musculus	83-86
8045666-7	1994	The strongest TNF eliciting and antitumor activity was found in the PH-I Cb fraction which is an acidic polysaccharide or proteoglycan with molecular weight of approximately 5000.	Polysaccharides	104-118	tumor necrosis factor	Mus musculus	14-17
7511169-8	1994	These results are consistent with the idea that sulfated glycans and Congo red inhibit protease-resistant PrP accumulation by interfering with the interaction of PrP with an endogenous glycosaminoglycan or proteoglycan.	Polysaccharides	57-64	prion protein	Mus musculus	106-109
7511169-8	1994	These results are consistent with the idea that sulfated glycans and Congo red inhibit protease-resistant PrP accumulation by interfering with the interaction of PrP with an endogenous glycosaminoglycan or proteoglycan.	Polysaccharides	57-64	prion protein	Mus musculus	162-165
8137947-2	1994	The glycans of gp160, part of which are highly sialylated, have been shown to influence gp160 immunogenicity.	Polysaccharides	4-11	glutamyl aminopeptidase	Homo sapiens	15-20
7999307-6	1994	Inhibitors of protease-resistant PrP accumulation have been identified, and these include the amyloid-binding dye Congo red and certain sulfated glycans.	Polysaccharides	145-152	prion protein	Mus musculus	33-36
8137947-2	1994	The glycans of gp160, part of which are highly sialylated, have been shown to influence gp160 immunogenicity.	Polysaccharides	4-11	glutamyl aminopeptidase	Homo sapiens	88-93
8133044-1	1994	Ra-reactive factor (RaRF), a C-dependent bactericidal factor in mice, is composed of one polysaccharide-binding component and one C4/C2-activating component.	Polysaccharides	89-103	mannan-binding lectin serine peptidase 1	Mus musculus	0-18
7509720-1	1994	CD44 is an integral membrane glycoprotein that functions as a receptor for the extracellular matrix glycan, hyaluronan.	Polysaccharides	100-106	CD44 molecule (Indian blood group)	Homo sapiens	0-4
7522606-0	1994	Suppression of in vivo tumor-induced angiogenesis by the protein-bound polysaccharide PSK.	Polysaccharides	71-85	TAO kinase 2	Mus musculus	86-89
7522606-1	1994	The anti-angiogenic effects of an antitumor protein-bound polysaccharide, PSK, obtained from cultured mycelia of Coriolus versicolor in basidiomycetes were examined by the mouse dorsal air sac assay.	Polysaccharides	58-72	TAO kinase 2	Mus musculus	74-77
7919129-0	1994	Enhancement of the antitumor effect by the concurrent use of a monoclonal antibody and the protein-bound polysaccharide PSK in mice bearing a human cancer cell line.	Polysaccharides	105-119	TAO kinase 2	Mus musculus	120-123
7919129-1	1994	The antitumor effects of a monoclonal antibody against a human cancer cell line and a protein-bound polysaccharide, PSK, obtained from cultured mycelia of Coriolus versicolor in basidiomycetes were examined.	Polysaccharides	100-114	TAO kinase 2	Homo sapiens	116-119
7510720-3	1994	As documented by intravital microscopy of small venules in the rabbit mesentery and tenuissimus muscle, leukocyte rolling was rapidly and profoundly reduced by intravenous treatment with the polysaccharide fucoidin, a homopolymer of sulfated L-fucose known to block the function of the leukocytic "rolling receptor" L-selectin.	Polysaccharides	191-205	L-selectin	Oryctolagus cuniculus	316-326
8133044-1	1994	Ra-reactive factor (RaRF), a C-dependent bactericidal factor in mice, is composed of one polysaccharide-binding component and one C4/C2-activating component.	Polysaccharides	89-103	mannan-binding lectin serine peptidase 1	Mus musculus	20-24
8043225-1	1994	OBJECTIVE: To investigate the binding of the sulphated polysaccharides, dextran sulphate and heparin, to CD4 and gp120 in order to examine the anti-HIV mechanisms of these compounds.	Polysaccharides	55-70	CD4 molecule	Homo sapiens	105-108
8016815-0	1994	Effects of heparan sulfate analogue or other sulfated polysaccharides on the activation of plasminogen by t-PA or u-PA.	Polysaccharides	54-69	plasminogen activator, tissue type	Homo sapiens	106-110
8043225-1	1994	OBJECTIVE: To investigate the binding of the sulphated polysaccharides, dextran sulphate and heparin, to CD4 and gp120 in order to examine the anti-HIV mechanisms of these compounds.	Polysaccharides	55-70	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	113-118
8043225-2	1994	DESIGN: In order to study the molecular mechanisms involved, the binding of sulphated polysaccharides to recombinant (r) sCD4 and gp120 was investigated in solid-phase binding studies that employed various monoclonal antibodies directed against known epitopes on these proteins, including the V3 loop of gp120.	Polysaccharides	86-101	stearoyl-CoA desaturase 5	Homo sapiens	121-125
8043225-2	1994	DESIGN: In order to study the molecular mechanisms involved, the binding of sulphated polysaccharides to recombinant (r) sCD4 and gp120 was investigated in solid-phase binding studies that employed various monoclonal antibodies directed against known epitopes on these proteins, including the V3 loop of gp120.	Polysaccharides	86-101	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	130-135
8043225-2	1994	DESIGN: In order to study the molecular mechanisms involved, the binding of sulphated polysaccharides to recombinant (r) sCD4 and gp120 was investigated in solid-phase binding studies that employed various monoclonal antibodies directed against known epitopes on these proteins, including the V3 loop of gp120.	Polysaccharides	86-101	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	304-309
8043225-3	1994	METHODS: The ability of sulphated polysaccharides to inhibit both the binding of gp120 to CD4 and the binding of the monoclonal antibodies was investigated by enzyme-linked immunosorbent assays.	Polysaccharides	34-49	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	81-86
8043225-3	1994	METHODS: The ability of sulphated polysaccharides to inhibit both the binding of gp120 to CD4 and the binding of the monoclonal antibodies was investigated by enzyme-linked immunosorbent assays.	Polysaccharides	34-49	CD4 molecule	Homo sapiens	90-93
8022334-5	1994	HIV envelope protein, gp120, carries glycan chains that are decided by the clone of the cells by which it is produced.	Polysaccharides	37-43	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	22-27
8181904-9	1994	Therefore, the effects of the antitumor polysaccharide SPR-901 used in combination with 5-FU were augmented as compared with single drug use.	Polysaccharides	40-54	sepiapterin reductase	Mus musculus	55-58
8180343-6	1994	Heparin species with longer polysaccharide chains appear to be required in order to enhance the inhibition of thrombin by antithrombin.	Polysaccharides	28-42	coagulation factor II, thrombin	Homo sapiens	110-118
8180343-6	1994	Heparin species with longer polysaccharide chains appear to be required in order to enhance the inhibition of thrombin by antithrombin.	Polysaccharides	28-42	serpin family C member 1	Homo sapiens	122-134
8022334-6	1994	Each cellular clone would be expected to add a specific group of glycan chains, making the gp120 antigenically separate.	Polysaccharides	65-71	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	91-96
7762433-0	1994	Primary and three-dimensional structure of lactotransferrin (lactoferrin) glycans.	Polysaccharides	74-81	lactotransferrin	Homo sapiens	43-59
7762433-2	1994	By associating permethylation-mass spectrometry and 1H-NMR spectroscopy, the primary structure of the human, bovine, caprine, murine and porcine lactotransferrin glycans were determined.	Polysaccharides	162-169	lactotransferrin	Mus musculus	145-161
7762433-4	1994	The results obtained led to the conclusion that glycans are specific for each transferrin and, for a given transferrin, specific to the species.	Polysaccharides	48-55	transferrin	Homo sapiens	78-89
7762433-4	1994	The results obtained led to the conclusion that glycans are specific for each transferrin and, for a given transferrin, specific to the species.	Polysaccharides	48-55	transferrin	Homo sapiens	107-118
7762433-7	1994	In contrast, the glycan associated with a protein is immobilized into only one conformation, as in the case of glycan-lectin associations or of "internal" glycan-protein interactions, like in rabbit serotransferrin, in which the glycan forms a bridge between the two lobes of the peptide chain, and maintains the protein in a biologically active conformation.	Polysaccharides	17-23	serotransferrin	Oryctolagus cuniculus	199-214
7925314-2	1994	The GPI anchor is composed of a core structure of phosphatidylinositol attached to a glycan chain which, in turn, is attached to the C-terminus of the protein.	Polysaccharides	85-91	glucose-6-phosphate isomerase	Sus scrofa	4-7
8172562-0	1993	Interaction of the capsular polysaccharide of Haemophilus influenzae type B with C1q.	Polysaccharides	28-42	complement C1q A chain	Homo sapiens	81-84
8011069-0	1994	Primary structure of the major glycan from human seminal transferrin.	Polysaccharides	31-37	transferrin	Homo sapiens	57-68
8172562-6	1993	Under physiological conditions the purified complement subcomponent C1q interacts with polyribosylribitolphosphate (PRP), the capsular polysaccharide of Hib.	Polysaccharides	135-149	complement C1q A chain	Homo sapiens	68-71
8172562-7	1993	The complex formation of C1q, the most basic serum protein, with this polyanion was demonstrated by several methods: agarose gel electrophoresis followed by immunoprecipitation in the gel and Coomassie staining; western blot analysis of C1q-PRP complexes; complex formation in electrophoretic separation of PRP; retardation of electrophoretic mobility of PRP was checked by blotting of this polysaccharide.	Polysaccharides	391-405	complement C1q A chain	Homo sapiens	25-28
8244930-3	1993	In this study the effect of the group 1 capsule regulators, RcsA, RcsB, and Lon protease, on the regulation of CP9"s capsular polysaccharides was assessed.	Polysaccharides	126-141	putative ATP-dependent Lon protease	Escherichia coli	76-79
8136414-6	1993	Glycan detection in the blotted fractions revealed that the bound prolactin fraction bands corresponding to M(r)25,000-29,000 were weakly glycolysated, whereas the bands of M(r)60,000-64,000 were significantly glycan-positive.	Polysaccharides	0-6	prolactin	Bos taurus	66-75
8136414-6	1993	Glycan detection in the blotted fractions revealed that the bound prolactin fraction bands corresponding to M(r)25,000-29,000 were weakly glycolysated, whereas the bands of M(r)60,000-64,000 were significantly glycan-positive.	Polysaccharides	210-216	prolactin	Bos taurus	66-75
8136414-7	1993	Immunoreactive bands of unbound prolactin fraction and retarded prolactin fraction also stained positively for glycans.	Polysaccharides	111-118	prolactin	Bos taurus	32-41
8136414-7	1993	Immunoreactive bands of unbound prolactin fraction and retarded prolactin fraction also stained positively for glycans.	Polysaccharides	111-118	prolactin	Bos taurus	64-73
8137133-5	1993	Congo red and certain sulfated glycans potently inhibit protease-resistant PrP formation or stabilization in cell culture.	Polysaccharides	31-38	prion protein	Homo sapiens	75-78
7506267-6	1993	Upregulation of L-selectin surface density in IFN-alpha-treated Daudi B cells correlated directly with an increase in L-selectin mRNA steady state levels and enhanced L-selectin-dependent binding to a carbohydrate-based ligand, phosphomonoester core polysaccharide.	Polysaccharides	250-264	selectin L	Homo sapiens	16-26
7506267-6	1993	Upregulation of L-selectin surface density in IFN-alpha-treated Daudi B cells correlated directly with an increase in L-selectin mRNA steady state levels and enhanced L-selectin-dependent binding to a carbohydrate-based ligand, phosphomonoester core polysaccharide.	Polysaccharides	250-264	interferon alpha 1	Homo sapiens	46-55
8254099-3	1993	This abnormal mobility might be due to the linked glycan phosphatidylinositol anchor in the ALP molecule, as the mobility became the same as that of the common liver type ALP after treatment with phosphatidylinositol specific phospholipase.	Polysaccharides	50-56	alkaline phosphatase, placental	Homo sapiens	92-95
8254099-3	1993	This abnormal mobility might be due to the linked glycan phosphatidylinositol anchor in the ALP molecule, as the mobility became the same as that of the common liver type ALP after treatment with phosphatidylinositol specific phospholipase.	Polysaccharides	50-56	alkaline phosphatase, placental	Homo sapiens	171-174
8156584-1	1993	This paper reports the effectiveness of SP-RIA in the antibody surveillance on population, the observation of immune persistence after vaccination with Group A Neisseria meningococcal capsular polysaccharide vaccine, as well as its use in the serological diagnosis of Neisseria meningitis.	Polysaccharides	193-207	small proline rich protein 1A	Homo sapiens	40-46
8010055-1	1993	The antitumor activities of Phytolacca acinosa polysaccharides I (PAP-I) and its effects on the induction of tumor necrosis factor (TNF) and immunological cytotoxicity of peritoneal macrophages were studied.	Polysaccharides	47-62	annexin A5	Mus musculus	66-71
8010055-1	1993	The antitumor activities of Phytolacca acinosa polysaccharides I (PAP-I) and its effects on the induction of tumor necrosis factor (TNF) and immunological cytotoxicity of peritoneal macrophages were studied.	Polysaccharides	47-62	tumor necrosis factor	Mus musculus	132-135
8265201-4	1993	Serum antibody reactive to the polysaccharide, as determined by enzyme-linked immunosorbent assay, was elevated in the group of mice immunized with the polysaccharide-protein conjugate but not in the mice immunized with bovine serum albumin.	Polysaccharides	31-45	albumin	Mus musculus	227-240
8269974-5	1993	Thus, it is suggested that many transformed cells have, as a common anomaly, the increased synthesis of the special type of glycan recognized by CSL, expressed on the same polypeptide chains.	Polysaccharides	124-130	recombination signal binding protein for immunoglobulin kappa J region	Homo sapiens	145-148
8265201-4	1993	Serum antibody reactive to the polysaccharide, as determined by enzyme-linked immunosorbent assay, was elevated in the group of mice immunized with the polysaccharide-protein conjugate but not in the mice immunized with bovine serum albumin.	Polysaccharides	152-166	albumin	Mus musculus	227-240
7915183-9	1993	The model provides an explanation for the observed instability of deglycosylated human CD2, and allows residues that are important for CD58 binding to be differentiated from those affecting conformational stability via interactions with the glycan.	Polysaccharides	241-247	CD2 molecule	Homo sapiens	87-90
8271916-8	1993	All vaccinated Finns exhibited the VH3-preference in antibodies to Hib and type 14 polysaccharide.	Polysaccharides	83-97	immunoglobulin heavy variable 3-75 (pseudogene)	Homo sapiens	35-38
8360147-8	1993	The lipids are linked via a glycerol-myo-inositol-PO4 to a core glycan with the structure -PO4-6)Gal(alpha 1-)Gal(alpha 1-) Galf(beta 1-)[Glc(alpha 1-PO4-)]Man(alpha 1-)Man(alpha 1-)GlcN(alpha 1-).	Polysaccharides	64-70	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	129-135
7915183-9	1993	The model provides an explanation for the observed instability of deglycosylated human CD2, and allows residues that are important for CD58 binding to be differentiated from those affecting conformational stability via interactions with the glycan.	Polysaccharides	241-247	CD58 molecule	Homo sapiens	135-139
8349043-7	1993	Glycan alpha had a significant effect only in the insulin-responsive group for which the observed activity ratio for 10 microM glycan alpha plus glucagon (0.68 +/- 0.05) compared closely with that for insulin plus glucagon (0.70 +/- 0.04).	Polysaccharides	0-6	insulin	Homo sapiens	50-57
8349043-7	1993	Glycan alpha had a significant effect only in the insulin-responsive group for which the observed activity ratio for 10 microM glycan alpha plus glucagon (0.68 +/- 0.05) compared closely with that for insulin plus glucagon (0.70 +/- 0.04).	Polysaccharides	127-133	insulin	Homo sapiens	50-57
8400551-4	1993	The predominant glycan (approximately 60% of total) had the structure GlcNAc beta 1-2Man alpha 1-3(Man alpha 1-6) Man beta 1-4GlcNAc beta 1-4GlcNAc-(Asn), with the remaining structures containing 1-3 additional hexose residues, as reported previously for bovine rhodopsin.	Polysaccharides	16-22	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	77-85
8373204-4	1993	PSK (a protein-bound polysaccharide preparation), IL-1 and Cepharanthin, cured not only the right, but also the left, non-treated tumor in a double grafted tumor system.	Polysaccharides	21-35	TAO kinase 2	Mus musculus	0-3
8400551-6	1993	FAB-MS analysis of oligosaccharides released from the Asn2 site gave, among other signals, an abundant quasimolecular ion corresponding to a glycan of composition NeuAc1Hex6HexNAc3 (where Hex is hexose and HexNAc is N-acetylhexosamine), consistent with a hybrid structure.	Polysaccharides	141-147	hematopoietically expressed homeobox	Homo sapiens	169-172
8400551-4	1993	The predominant glycan (approximately 60% of total) had the structure GlcNAc beta 1-2Man alpha 1-3(Man alpha 1-6) Man beta 1-4GlcNAc beta 1-4GlcNAc-(Asn), with the remaining structures containing 1-3 additional hexose residues, as reported previously for bovine rhodopsin.	Polysaccharides	16-22	adrenoceptor alpha 1D	Homo sapiens	103-112
8400551-4	1993	The predominant glycan (approximately 60% of total) had the structure GlcNAc beta 1-2Man alpha 1-3(Man alpha 1-6) Man beta 1-4GlcNAc beta 1-4GlcNAc-(Asn), with the remaining structures containing 1-3 additional hexose residues, as reported previously for bovine rhodopsin.	Polysaccharides	16-22	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	77-83
8400551-4	1993	The predominant glycan (approximately 60% of total) had the structure GlcNAc beta 1-2Man alpha 1-3(Man alpha 1-6) Man beta 1-4GlcNAc beta 1-4GlcNAc-(Asn), with the remaining structures containing 1-3 additional hexose residues, as reported previously for bovine rhodopsin.	Polysaccharides	16-22	rhodopsin	Bos taurus	262-271
8400551-5	1993	Unlike bovine rhodopsin, however, a sizable fraction of the total glycans of frog rhodopsin also contained sialic acid (NeuAc), with the sialylated oligosaccharides being present exclusively at the Asn2 site.	Polysaccharides	66-73	rhodopsin	Bos taurus	82-91
8102473-0	1993	CD4-derived peptide and sulfated polysaccharides have similar mechanisms of anti-HIV activity based on electrostatic interactions with positively charged gp120 fragments.	Polysaccharides	33-48	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	154-159
8407056-1	1993	Protein-bound polysaccharide, PSK, is a biological response modifier and influences various immunological functions in vivo, including those of T-cells.	Polysaccharides	14-28	TAO kinase 2	Mus musculus	30-33
8340385-11	1993	The most polar of these GIPLs, LPGp, has the properties expected of a biosynthetic precursor to the LPG, having the structure, [formula: see text] Finally, the GPI anchors of the major promastigote proteins were found to contain the glycan sequence Man alpha 1-2Man alpha 1-6Man alpha 1-4GlcN, and an alkylacyl-PI lipid moiety which was highly enriched for C24:0 or C26:0 alkyl chains.	Polysaccharides	233-239	thyroid hormone responsive	Homo sapiens	31-35
8337029-2	1993	OBJECTIVE: To study the safety, immunogenicity, and protective efficacy of the Haemophilus influenzae capsular polysaccharide tetanus conjugate vaccine (PRP-T).	Polysaccharides	111-125	prion protein	Homo sapiens	153-156
8340385-11	1993	The most polar of these GIPLs, LPGp, has the properties expected of a biosynthetic precursor to the LPG, having the structure, [formula: see text] Finally, the GPI anchors of the major promastigote proteins were found to contain the glycan sequence Man alpha 1-2Man alpha 1-6Man alpha 1-4GlcN, and an alkylacyl-PI lipid moiety which was highly enriched for C24:0 or C26:0 alkyl chains.	Polysaccharides	233-239	thyroid hormone responsive	Homo sapiens	31-34
8335909-1	1993	We have previously shown that human antibody (Ab) directed against the capsular polysaccharide of the important bacterial pathogen, Haemophilus influenzae type b (Hib) is encoded by a small group of VH3 gene family members.	Polysaccharides	80-94	immunoglobulin heavy variable 3-75 (pseudogene)	Homo sapiens	199-202
8332900-1	1993	Mice that bear the X-linked immunodeficiency (xid) mutation have a B lymphocyte-specific defect resulting in an inability to make antibody responses to polysaccharide antigens.	Polysaccharides	152-166	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	46-49
8249628-1	1993	Achyranthes bidentata polysaccharides (ABP), extracted from the root of Achyranthes bidentata, induced interleukin-1 (IL-1) synthesis as well as tumor necrosis factor-alpha (TNF-alpha) synthesis and secretion from thioglycolate-primed mouse peritoneal macrophages in vitro.	Polysaccharides	22-37	tumor necrosis factor	Mus musculus	174-183
8344280-9	1993	An IL-2 mutant form, with an 11-amino-acid peptide of human interferon-beta at position 4, which includes its only N-glycosylation site, had exclusively truncated proximally fucosylated oligomannosidic glycans; Man3GlcNAc[Fuc(alpha 1-6)]GlcNAc or Man2GlcNAc[Fuc(alpha 1-6)]GlcNAc structures, in a ratio of 3:1, were detected in the secreted proteins.	Polysaccharides	202-209	interleukin 2	Homo sapiens	3-7
8344280-9	1993	An IL-2 mutant form, with an 11-amino-acid peptide of human interferon-beta at position 4, which includes its only N-glycosylation site, had exclusively truncated proximally fucosylated oligomannosidic glycans; Man3GlcNAc[Fuc(alpha 1-6)]GlcNAc or Man2GlcNAc[Fuc(alpha 1-6)]GlcNAc structures, in a ratio of 3:1, were detected in the secreted proteins.	Polysaccharides	202-209	interferon beta 1	Homo sapiens	60-75
8403434-0	1993	Glycan microheterogeneity of alpha 1-antitrypsin in serum and meconium from normal and cystic fibrosis patients by crossed immunoaffinoelectrophoresis with different lectins (Con A, LCA, WGA).	Polysaccharides	0-6	serpin family A member 1	Homo sapiens	29-48
7686045-4	1993	The ability of heparin to stabilize aFGF is critically dependent upon many factors including the number of aFGF molecules bound to the heparin chain, ionic strength, temperature, and the extent of sulfation of the polysaccharide.	Polysaccharides	214-228	fibroblast growth factor 1	Homo sapiens	36-40
8335699-1	1993	Three sulphated polysaccharides, dermatan sulphate, fucan and heparin, were fractionated according to their affinity towards antithrombin III (ATIII) and heparin cofactor II (HCII), the two main physiological thrombin (IIa) inhibitors.	Polysaccharides	16-31	serpin family C member 1	Homo sapiens	125-141
8335699-1	1993	Three sulphated polysaccharides, dermatan sulphate, fucan and heparin, were fractionated according to their affinity towards antithrombin III (ATIII) and heparin cofactor II (HCII), the two main physiological thrombin (IIa) inhibitors.	Polysaccharides	16-31	serpin family C member 1	Homo sapiens	143-148
8335699-1	1993	Three sulphated polysaccharides, dermatan sulphate, fucan and heparin, were fractionated according to their affinity towards antithrombin III (ATIII) and heparin cofactor II (HCII), the two main physiological thrombin (IIa) inhibitors.	Polysaccharides	16-31	serpin family D member 1	Homo sapiens	154-173
8335699-5	1993	The possible presence of a unique binding site for ATIII and HCII, on each sulphated polysaccharide, was also studied.	Polysaccharides	85-99	serpin family C member 1	Homo sapiens	51-56
8335699-5	1993	The possible presence of a unique binding site for ATIII and HCII, on each sulphated polysaccharide, was also studied.	Polysaccharides	85-99	serpin family D member 1	Homo sapiens	61-65
8509458-0	1993	The fourth immunoglobulin-like domain of NCAM contains a carbohydrate recognition domain for oligomannosidic glycans implicated in association with L1 and neurite outgrowth.	Polysaccharides	109-116	neural cell adhesion molecule 1	Mus musculus	41-45
8505334-7	1993	To characterize alg3 glycan elongation in vivo, oligosaccharides on alg3,sec18 invertase synthesized and secreted at 26 degrees C were released with peptide-N4-N-acetyl-beta-glucosaminyl asparagine amidase and purified by Bio-Gel P-4 chromatography.	Polysaccharides	21-27	ALG3 alpha-1,3- mannosyltransferase	Homo sapiens	16-20
8390218-0	1993	Structural analysis on the sugar chains of human alpha 1-antitrypsin: presence of fucosylated biantennary glycan in hepatocellular carcinoma.	Polysaccharides	106-112	serpin family A member 1	Homo sapiens	49-68
7763876-5	1993	FA-2: A protein-containing mannogalactan, MW 120,000, polysaccharide: protein = 76:16 (w/w), consisting of Xyl:Man:Gal = 9:35:56 (molar ratio), [alpha]D23 + 98.5 degrees.	Polysaccharides	54-68	FA complementation group B	Homo sapiens	0-4
8364506-0	1993	Interaction of a protein-bound polysaccharide (PSK) with chicken gizzard caldesmon.	Polysaccharides	31-45	caldesmon 1	Gallus gallus	73-82
8364506-1	1993	The interaction of a protein-bound polysaccharide (PSK) with caldesmon was studied in detail using sedimentation, low-shear viscometry, electron microscopy and affinity chromatography.	Polysaccharides	35-49	caldesmon 1	Gallus gallus	61-70
8334107-5	1993	The polysaccharide sample carrying the IFN-gamma-inducing activity with a molecular weight of 700,000 was destroyed by treatment with acid or sodium metaperiodate, but was stable to treatment with heat, alkali, pronase, or neuraminidase.	Polysaccharides	4-18	interferon gamma	Homo sapiens	39-48
7684608-1	1993	The binding of human acidic fibroblast growth factor (aFGF) to heparin has been analyzed by a variety of different approaches to better elucidate the nature of this protein/sulfated polysaccharide interaction.	Polysaccharides	182-196	fibroblast growth factor 1	Homo sapiens	21-52
7684608-1	1993	The binding of human acidic fibroblast growth factor (aFGF) to heparin has been analyzed by a variety of different approaches to better elucidate the nature of this protein/sulfated polysaccharide interaction.	Polysaccharides	182-196	fibroblast growth factor 1	Homo sapiens	54-58
7684608-6	1993	Thus, aFGF appears to bind at high density (one molecule every 4-5 polysaccharide units) and with high affinity to heparin.	Polysaccharides	67-81	fibroblast growth factor 1	Homo sapiens	6-10
8508806-9	1993	Moreover, tryptic digestion studies performed with various heparin molecules and dextran sulfates of different size, ranging from 2.0 kDa to 500 kDa, indicate that the number of bFGF molecules which interact with a single molecule of polysaccharide is related to the molecular mass of the GAG and that six hexose residues are sufficient to protect 1-2 molecules bFGF.	Polysaccharides	234-248	fibroblast growth factor 2	Homo sapiens	178-182
8508806-9	1993	Moreover, tryptic digestion studies performed with various heparin molecules and dextran sulfates of different size, ranging from 2.0 kDa to 500 kDa, indicate that the number of bFGF molecules which interact with a single molecule of polysaccharide is related to the molecular mass of the GAG and that six hexose residues are sufficient to protect 1-2 molecules bFGF.	Polysaccharides	234-248	fibroblast growth factor 2	Homo sapiens	362-366
8334107-5	1993	The polysaccharide sample carrying the IFN-gamma-inducing activity with a molecular weight of 700,000 was destroyed by treatment with acid or sodium metaperiodate, but was stable to treatment with heat, alkali, pronase, or neuraminidase.	Polysaccharides	4-18	neuraminidase 1	Homo sapiens	223-236
8334107-8	1993	These findings indicate that the polysaccharide sample purified by the affinity chromatography of butanol extract of OK-432 on CNBr-activated Sepharose 4B-bound TS-2 MAb carries the IFN-gamma-inducing activity of OK-432 and marked antitumor activity.	Polysaccharides	33-47	interferon gamma	Homo sapiens	182-191
8083500-0	1993	Number and affinity of transferrin-receptors at the placental microvillous plasma membrane of the guinea pig: influence of gestational age and degree of transferrin glycan chain complexity.	Polysaccharides	165-171	inhibitor of carbonic anhydrase	Cavia porcellus	153-164
8317896-1	1993	PSK (Krestin), a protein-bound polysaccharide extracted from Coriolus versicolor, stimulated the production of interleukin-1 (IL-1) by human peripheral blood mononuclear cells more efficiently than the production of tumor necrosis factor (TNF).	Polysaccharides	31-45	TAO kinase 2	Homo sapiens	0-3
8389297-1	1993	A fluorescent lactotransferrin probe was prepared by coupling 5-(([2-(carbhydrazino)methyl]-thio)acetyl)amino fluorescein to aldehyde groups that were produced by a mild periodic-acid oxidation of the glycan moieties of lactotransferrin.	Polysaccharides	201-207	lactotransferrin	Homo sapiens	14-30
8478081-0	1993	Similar mechanisms of action of defined polysaccharides and lipopolysaccharides: characterization of binding and tumor necrosis factor alpha induction.	Polysaccharides	40-55	tumor necrosis factor	Homo sapiens	113-140
8043831-1	1993	The investigation reveals different influence of the plague microbe"s fraction 1 polysaccharide-protein complex and of it"s purified protein on the 5"-nucleotidase activity and on the chemiluminescence response of peritoneal macrophages.	Polysaccharides	81-95	5'-nucleotidase ecto	Homo sapiens	148-163
8495497-7	1993	Finally, while anti-IL-10 treated mice were unable to produce antibodies to phosphorylcholine and alpha 1,3-dextran, they developed normal antibody responses following intraperitoneal injections of TNP-Ficoll, suggesting the existence of subcategories within the family of thymus independent type II polysaccharide antigens.	Polysaccharides	300-314	interleukin 10	Mus musculus	20-25
8495104-1	1993	Although having variability in primary sequence, the v3 loop of gp120 in pathogenic strains of human immunodeficiency virus type-1 (HIV-1) is positively charged and known to interact with sulfated polysaccharides.	Polysaccharides	197-212	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	64-69
8472428-1	1993	Hyaluronate (HA) is linear unbranched polysaccharide consisting of repeating disaccharide units of (1-4)-D-glucuronic acid-beta-(1-3)-D-N-acetylglucosamine.	Polysaccharides	38-52	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	123-132
8444997-6	1993	When polysaccharide hydrolysates were fractionated using a gradient program capable of resolving all of the oligosaccharide species, dextran-derived alpha-(1--&gt;6)-glucooligosaccharides were retained to a greater degree than amylose-derived alpha-(1--&gt;4)-glucooligosaccharides, which were retained to a greater degree than beta-(2--&gt;1)-fructooligosaccharides derived from inulin.	Polysaccharides	5-19	adrenoceptor alpha 1D	Homo sapiens	149-157
8364170-1	1993	PSK, a protein-bound polysaccharide derived from basidiomycetes, is a biological response modifier that exhibits a variety of activities following oral administration, including prevention of infection.	Polysaccharides	21-35	TAO kinase 2	Mus musculus	0-3
8502198-2	1993	The bacterial polysaccharides stimulate gingival neutrophils and macrophages to interleukin-1 (IL-1) production.	Polysaccharides	14-29	interleukin 1 alpha	Homo sapiens	80-99
8100569-4	1993	Both aurintricarboxylic acid and sulfonated polysaccharides (e.g., dextran sulfate) blocked CD4-gp120 interactions by binding to the CD4 component.	Polysaccharides	44-59	CD4 molecule	Homo sapiens	92-95
8100569-4	1993	Both aurintricarboxylic acid and sulfonated polysaccharides (e.g., dextran sulfate) blocked CD4-gp120 interactions by binding to the CD4 component.	Polysaccharides	44-59	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	96-101
8100569-4	1993	Both aurintricarboxylic acid and sulfonated polysaccharides (e.g., dextran sulfate) blocked CD4-gp120 interactions by binding to the CD4 component.	Polysaccharides	44-59	CD4 molecule	Homo sapiens	133-136
7763539-1	1993	A novel immunomodulating fraction, SP-MAF1, was isolated from soybeans as a polysaccharide-protein complex by hot water extraction followed by acid treatment, ethanol treatment, and chromatography on a DEAE-Sepharose CL-6B column, and was characterized in some biological activities.	Polysaccharides	76-90	MFP1 attachment factor 1	Glycine max	38-42
8490003-5	1993	Bean non-cellulosic polysaccharides were highly digestible with values of 0.98, 0.88 and 0.99 for arabinose, xylose and uronic acids components respectively.	Polysaccharides	20-35	brain expressed, associated with NEDD4, 1	Rattus norvegicus	0-4
8444997-6	1993	When polysaccharide hydrolysates were fractionated using a gradient program capable of resolving all of the oligosaccharide species, dextran-derived alpha-(1--&gt;6)-glucooligosaccharides were retained to a greater degree than amylose-derived alpha-(1--&gt;4)-glucooligosaccharides, which were retained to a greater degree than beta-(2--&gt;1)-fructooligosaccharides derived from inulin.	Polysaccharides	5-19	adrenoceptor alpha 1D	Homo sapiens	243-251
8444997-6	1993	When polysaccharide hydrolysates were fractionated using a gradient program capable of resolving all of the oligosaccharide species, dextran-derived alpha-(1--&gt;6)-glucooligosaccharides were retained to a greater degree than amylose-derived alpha-(1--&gt;4)-glucooligosaccharides, which were retained to a greater degree than beta-(2--&gt;1)-fructooligosaccharides derived from inulin.	Polysaccharides	5-19	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	328-335
8432729-6	1993	However, in I-cells, granzymes cannot bear Man-6-P and granzyme B acquires complex glycans, becoming Endo H resistant.	Polysaccharides	83-90	granzyme B	Homo sapiens	55-65
1457416-1	1992	The structure of the glycans of the A-chain of human plasma alpha 2HS-glycoprotein was established from the chemical compositions of its derivatives prepared by sequential enzymatic degradation of the carbohydrate moiety, from the determination of the kind and amount of the monosaccharides liberated after each step of the enzymatic digestion, and from the distinct specificity of the highly purified exoglycosidases.	Polysaccharides	21-28	alpha 2-HS glycoprotein	Homo sapiens	60-82
8445090-10	1993	Nevertheless, the forms of lactoferrin result from the presence of glycans on the protein.	Polysaccharides	67-74	lactotransferrin	Bos taurus	27-38
7678300-7	1993	This comparison provided evidence that the density of sulfation and molecular size are factors influencing anti-PrP-res activity of sulfated glycans.	Polysaccharides	141-148	prion protein	Homo sapiens	112-115
8167745-10	1993	Though antibodies to polysaccharide antigens in young children are mainly of the IgM and IgG1 (IgG3) isotype, in older children and adults the polysaccharide antibodies are predominantly localized in the IgG2 subclass.	Polysaccharides	21-35	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	95-99
8419396-1	1993	The effects of sulfated polysaccharides on the growth and chemotaxis of endothelial cells promoted by basic fibroblast growth factor (bFGF), a heparin-binding growth factor, and epidermal growth factor (EGF), a non-heparin-binding growth factor, were examined.	Polysaccharides	24-39	fibroblast growth factor 2	Homo sapiens	102-132
8348231-0	1993	Release of O-linked glycoprotein glycans by endo-alpha-N-acetylgalactosaminidase.	Polysaccharides	33-40	alpha-N-acetylgalactosaminidase	Homo sapiens	49-80
1337862-7	1992	These results show that the structures of bovine lactotransferrin glycans are more heterogeneous than those of previously characterized transferrin glycans.	Polysaccharides	66-73	lactotransferrin	Bos taurus	49-65
1337862-7	1992	These results show that the structures of bovine lactotransferrin glycans are more heterogeneous than those of previously characterized transferrin glycans.	Polysaccharides	66-73	serotransferrin	Bos taurus	54-65
1460286-2	1992	One of these conjugates, polysaccharide linked to outer membrane protein complex (PRP-OMPC), is produced by linking the capsular polysaccharide to an outer membrane protein complex derived from group B Neisseria meningitidis.	Polysaccharides	25-39	prion protein	Mus musculus	82-85
1460286-2	1992	One of these conjugates, polysaccharide linked to outer membrane protein complex (PRP-OMPC), is produced by linking the capsular polysaccharide to an outer membrane protein complex derived from group B Neisseria meningitidis.	Polysaccharides	129-143	prion protein	Mus musculus	82-85
8380463-8	1993	However, mutant proteins lacking glycans at residue 102 (gN2) or residues 41 and 102 (gN1N2) showed altered reactivity with conformation-dependent gIV-specific monoclonal antibodies.	Polysaccharides	33-40	glycogenin 2	Homo sapiens	57-60
8418172-5	1993	IgG3 was superior in binding to multivalent PS both in purified and whole bacterial form, fixation of the third component of complement to the bacterial surface, and opsonization of P. aeruginosa for uptake by both murine and human phagocytes.	Polysaccharides	44-46	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	0-4
8475019-5	1993	The main protein component of the polysaccharide phase was alpha-lactalbumin.	Polysaccharides	34-48	lactalbumin alpha	Homo sapiens	59-76
8009984-1	1993	The effects of Phytolacca acinosa polysaccharides I (PAP-I), a polysaccharide extracted from Phytolacca acinosa Roxb: on splenic lymphocyte proliferation and cytokines production from splenic lymphocyte and macrophage were studied.	Polysaccharides	34-49	annexin A5	Mus musculus	53-58
1291045-1	1992	Resolution and structural characterization of ovalbumin glycans.	Polysaccharides	56-63	ovalbumin (SERPINB14)	Gallus gallus	46-55
1431143-0	1992	Intranasal immunization with liposomes containing IL-2 enhances bacterial polysaccharide antigen-specific pulmonary secretory antibody response.	Polysaccharides	74-88	interleukin 2	Mus musculus	50-54
1493802-10	1992	Sulfated polysaccharides such as heparinsulfate and dermatansulfate modulate the interaction of 5"-nucleotidase and laminin/nidogen in a complex biphasic manner and might also regulate the binding reaction in vivo.	Polysaccharides	9-24	5'-nucleotidase ecto	Gallus gallus	96-111
1493802-10	1992	Sulfated polysaccharides such as heparinsulfate and dermatansulfate modulate the interaction of 5"-nucleotidase and laminin/nidogen in a complex biphasic manner and might also regulate the binding reaction in vivo.	Polysaccharides	9-24	laminin, beta 2 (laminin S)	Gallus gallus	116-123
1458593-0	1992	Placental alkaline phosphatase: a model for studying COOH-terminal processing of phosphatidylinositol-glycan-anchored membrane proteins.	Polysaccharides	102-108	alkaline phosphatase, placental	Homo sapiens	0-30
1431143-4	1992	Inclusion of IL-2, but not IL-4, into the intranasally administered liposomes further increased titers of bacterial polysaccharide specific sIgA and pulmonary plasma cells.	Polysaccharides	116-130	interleukin 2	Mus musculus	13-17
1431143-5	1992	Intranasal vaccination with liposomes containing bacterial polysaccharide and 10 micrograms/kg IL-2 increased bacterial polysaccharide-specific pulmonary plasma cell numbers by more than 80-fold compared with the response in mice immunized with liposomes containing bacterial polysaccharide, but without IL-2.	Polysaccharides	59-73	interleukin 2	Mus musculus	304-308
1431143-5	1992	Intranasal vaccination with liposomes containing bacterial polysaccharide and 10 micrograms/kg IL-2 increased bacterial polysaccharide-specific pulmonary plasma cell numbers by more than 80-fold compared with the response in mice immunized with liposomes containing bacterial polysaccharide, but without IL-2.	Polysaccharides	120-134	interleukin 2	Mus musculus	95-99
1431143-5	1992	Intranasal vaccination with liposomes containing bacterial polysaccharide and 10 micrograms/kg IL-2 increased bacterial polysaccharide-specific pulmonary plasma cell numbers by more than 80-fold compared with the response in mice immunized with liposomes containing bacterial polysaccharide, but without IL-2.	Polysaccharides	120-134	interleukin 2	Mus musculus	95-99
1486679-5	1992	In pregnancy an increase in transferrin concentration was accompanied by redirection of glycan synthesis to the highly sialylated and highly branched glycans, an effect also shown in women using oral contraceptives.	Polysaccharides	88-94	transferrin	Homo sapiens	28-39
1449473-1	1992	Therapeutic effects of four types of recombinant superoxide dismutase (SOD) derivatives, conjugates with polysaccharides, carboxymethyl (SOD-CMD) and diethylaminoethyl (SOD-DEAED) dextrans and galactosylated (Gal-SOD) and mannosylated (Man-SOD) derivatives, on hepatic ischemia/reperfusion injury were studied in rats.	Polysaccharides	105-120	superoxide dismutase 1	Homo sapiens	71-74
1486679-5	1992	In pregnancy an increase in transferrin concentration was accompanied by redirection of glycan synthesis to the highly sialylated and highly branched glycans, an effect also shown in women using oral contraceptives.	Polysaccharides	150-157	transferrin	Homo sapiens	28-39
1489092-0	1992	Carbohydrate analysis of water-soluble uronic acid-containing polysaccharides with high-performance anion-exchange chromatography using methanolysis combined with TFA hydrolysis is superior to four other methods.	Polysaccharides	62-77	coagulation factor III, tissue factor	Homo sapiens	163-166
1489092-1	1992	Sulfuric acid hydrolysis according to the Saeman procedure, TFA hydrolysis, and methanolysis combined with TFA hydrolysis were compared for the hydrolysis of water-soluble uronic acid-containing polysaccharides originating from fungi, plants, and animals.	Polysaccharides	195-210	coagulation factor III, tissue factor	Homo sapiens	107-110
1478888-5	1992	The glycoprotein ligands recognized with higher affinity by these two lectins seem to possess a special structure which defines a sub-class of oncofetal HNK-1 glycans.	Polysaccharides	159-166	beta-1,3-glucuronyltransferase 1	Homo sapiens	153-158
1338913-0	1992	The relationship between polysaccharide antigen and interleukin-1 beta producing activity in Porphyromonas gingivalis.	Polysaccharides	25-39	interleukin 1 beta	Homo sapiens	52-70
1338913-6	1992	The results of immunoblotting tests and IL-1 beta production indicated that there are serogroup-specific polysaccharide other than lipopolysaccharide in P. gingivalis.	Polysaccharides	105-119	interleukin 1 beta	Homo sapiens	40-49
1425926-1	1992	The binding of interleukin (IL)-1 alpha, IL-1 beta, IL-2 and IL-6 to acidic polysaccharides was investigated by affinity chromatography of the recombinant, radioiodinated interleukins on columns of immobilized polysaccharide.	Polysaccharides	76-91	interleukin 1 alpha	Mus musculus	15-39
1425926-1	1992	The binding of interleukin (IL)-1 alpha, IL-1 beta, IL-2 and IL-6 to acidic polysaccharides was investigated by affinity chromatography of the recombinant, radioiodinated interleukins on columns of immobilized polysaccharide.	Polysaccharides	76-91	interleukin 1 beta	Mus musculus	41-50
1425926-1	1992	The binding of interleukin (IL)-1 alpha, IL-1 beta, IL-2 and IL-6 to acidic polysaccharides was investigated by affinity chromatography of the recombinant, radioiodinated interleukins on columns of immobilized polysaccharide.	Polysaccharides	76-91	interleukin 2	Mus musculus	52-56
1425926-1	1992	The binding of interleukin (IL)-1 alpha, IL-1 beta, IL-2 and IL-6 to acidic polysaccharides was investigated by affinity chromatography of the recombinant, radioiodinated interleukins on columns of immobilized polysaccharide.	Polysaccharides	76-91	interleukin 6	Mus musculus	61-65
1425926-1	1992	The binding of interleukin (IL)-1 alpha, IL-1 beta, IL-2 and IL-6 to acidic polysaccharides was investigated by affinity chromatography of the recombinant, radioiodinated interleukins on columns of immobilized polysaccharide.	Polysaccharides	76-90	interleukin 1 alpha	Mus musculus	15-39
1425926-1	1992	The binding of interleukin (IL)-1 alpha, IL-1 beta, IL-2 and IL-6 to acidic polysaccharides was investigated by affinity chromatography of the recombinant, radioiodinated interleukins on columns of immobilized polysaccharide.	Polysaccharides	76-90	interleukin 1 beta	Mus musculus	41-50
1425926-1	1992	The binding of interleukin (IL)-1 alpha, IL-1 beta, IL-2 and IL-6 to acidic polysaccharides was investigated by affinity chromatography of the recombinant, radioiodinated interleukins on columns of immobilized polysaccharide.	Polysaccharides	76-90	interleukin 2	Mus musculus	52-56
1425926-1	1992	The binding of interleukin (IL)-1 alpha, IL-1 beta, IL-2 and IL-6 to acidic polysaccharides was investigated by affinity chromatography of the recombinant, radioiodinated interleukins on columns of immobilized polysaccharide.	Polysaccharides	76-90	interleukin 6	Mus musculus	61-65
1338273-1	1992	Iodination stimulators, such as the dehydrogenation polymer of caffeic acid (DHP-CA), a protein-bound polysaccharide (PSK), and a commercially available tannic acid, potently inhibited the luciferin-dependent chemiluminescence (LDCL) generated by opsonized zymosan-stimulated human peripheral blood polymorphonuclear cells (PMN).	Polysaccharides	102-116	TAO kinase 2	Homo sapiens	118-121
1338274-2	1992	Flow cytometry analyses of the reversible binding of lactotransferrin labeled on its glycan moiety with fluorescein indicate, for the first time, that all these epithelial breast cell lines, express a specific lactotransferrin receptor.	Polysaccharides	85-91	lactotransferrin	Homo sapiens	53-69
1421410-10	1992	The presence of intact glycans in the total population of Tn erythrocytes was confirmed by their susceptibility to T activation after treatment with neuraminidase.	Polysaccharides	23-30	neuraminidase 1	Homo sapiens	149-162
1409574-10	1992	Our model of heparin bound to PF4 has the anionic polysaccharide perpendicular to the alpha-helices, wrapped about the tetramer along the ring of positive charge, and salt linked to all four lysines on the helix of each monomer.	Polysaccharides	50-64	platelet factor 4	Bos taurus	30-33
1398925-5	1992	Of the SCID-PBL-Hu mice that were immunized with a 23-valent pneumococcal polysaccharide vaccine, 63 to 78% developed a significant human IgG antipneumococcal antibody response, whereas only very low levels of human IgM and no human IgA antipneumococcal antibodies could be detected.	Polysaccharides	74-88	protein kinase, DNA activated, catalytic polypeptide	Mus musculus	7-11
1398925-5	1992	Of the SCID-PBL-Hu mice that were immunized with a 23-valent pneumococcal polysaccharide vaccine, 63 to 78% developed a significant human IgG antipneumococcal antibody response, whereas only very low levels of human IgM and no human IgA antipneumococcal antibodies could be detected.	Polysaccharides	74-88	immunoglobulin heavy variable V1-62	Mus musculus	138-141
1398925-5	1992	Of the SCID-PBL-Hu mice that were immunized with a 23-valent pneumococcal polysaccharide vaccine, 63 to 78% developed a significant human IgG antipneumococcal antibody response, whereas only very low levels of human IgM and no human IgA antipneumococcal antibodies could be detected.	Polysaccharides	74-88	immunoglobulin heavy constant mu	Mus musculus	216-219
1328232-10	1992	In contrast to T. brucei, preliminary experiments indicate that the core glycan of some GPIs synthesized by the T. gondii cell-free system is modified by N-acetylgalactosamine similar to the situation for mammalian Thy-1.	Polysaccharides	73-79	Thy-1 cell surface antigen	Homo sapiens	215-220
1398485-0	1992	The perfused liver is capable of producing all transferrin glycan variants found in the sera of intact rats.	Polysaccharides	59-65	transferrin	Rattus norvegicus	47-58
1398485-3	1992	To this end we analyzed the glycans of rat transferrin synthesized by the isolated perfused rat liver by a method established earlier for rat transferrin isolated from rat plasma.	Polysaccharides	28-35	transferrin	Rattus norvegicus	43-54
1398485-4	1992	Our observations provide evidence that the liver can and does produce all variant rat transferrin glycans present in plasma.	Polysaccharides	98-105	transferrin	Rattus norvegicus	86-97
1398485-5	1992	However, this discovery does not preclude the possibility that extrahepatic sources with an active rat transferrin gene may contribute to the circulation rat transferrin molecules, which bear glycan variants identical to those made by the liver.	Polysaccharides	192-198	transferrin	Rattus norvegicus	103-114
1398485-5	1992	However, this discovery does not preclude the possibility that extrahepatic sources with an active rat transferrin gene may contribute to the circulation rat transferrin molecules, which bear glycan variants identical to those made by the liver.	Polysaccharides	192-198	transferrin	Rattus norvegicus	158-169
1398485-6	1992	The glycan spectra of rat transferrin in plasma and in liver perfusate compared closely with each other in a quantitative sense.	Polysaccharides	4-10	transferrin	Rattus norvegicus	26-37
1396415-5	1992	It is concluded that the HNE-induced expression of the mucous cell phenotype is associated with an increase in the amount of neutral and acidic nonsulfated and noncarboxylated polysaccharides stored in the secretory granules of these cells.	Polysaccharides	176-191	elastase, neutrophil expressed	Homo sapiens	25-28
1527037-3	1992	The strong reaction with desialized porcine and rat salivary glycoproteins as well as pneumococcus type XIV polysaccharide suggests that APA has affinity for one or more of the following carbohydrate sequences: Thomsen-Friedenreich (T, Gal beta 1----3GalNAc), blood group precursor type I and/or type II (Gal beta 1----3/4GlcNAc) disaccharide determinants of complex carbohydrates.	Polysaccharides	108-122	glutamyl aminopeptidase	Rattus norvegicus	137-140
1512295-12	1992	Nectadrin thus appears to be a self-binding cell adhesion molecule of a structurally novel type in that its extensive glycan structures may be implicated in mediating cell adhesion.	Polysaccharides	118-124	CD24a antigen	Mus musculus	0-9
1380957-10	1992	3) Glycans in the incomplete GPIs that accumulate in classes B and F lymphoma mutants consist of Man2- and Man3GlcN in which EthN-P is linked to Man 1.	Polysaccharides	3-10	LEM domain containing 3	Homo sapiens	145-150
1472720-4	1992	We show here that one gene, nodC, shows striking similarity to genes encoding proteins known to be involved in polysaccharide synthesis in yeast and bacteria, specifically chitin and cellulose synthases, as well as a protein with unknown function in Xenopus embryos, DG42.	Polysaccharides	111-125	hyaluronan synthase 1 S homeolog	Xenopus laevis	267-271
1377990-0	1992	Human anti-pneumococcal polysaccharide antibodies are secreted by the CD5- B cell lineage.	Polysaccharides	24-38	CD5 molecule	Homo sapiens	70-73
1476702-1	1992	Production of rat transferrin containing a single hybrid glycan was induced by treating rats with swainsonine, an inhibitor of alpha-mannosidase II.	Polysaccharides	57-63	transferrin	Rattus norvegicus	18-29
1476702-1	1992	Production of rat transferrin containing a single hybrid glycan was induced by treating rats with swainsonine, an inhibitor of alpha-mannosidase II.	Polysaccharides	57-63	mannosidase, alpha, class 2A, member 1	Rattus norvegicus	127-147
1476702-3	1992	Transferrin bearing the hybrid glycan was degraded in vivo with a half-life of 14 h as compared with 40 h for transferrin containing a standard diantennary glycan.	Polysaccharides	31-37	transferrin	Rattus norvegicus	0-11
1476702-3	1992	Transferrin bearing the hybrid glycan was degraded in vivo with a half-life of 14 h as compared with 40 h for transferrin containing a standard diantennary glycan.	Polysaccharides	31-37	transferrin	Rattus norvegicus	110-121
1476702-3	1992	Transferrin bearing the hybrid glycan was degraded in vivo with a half-life of 14 h as compared with 40 h for transferrin containing a standard diantennary glycan.	Polysaccharides	156-162	transferrin	Rattus norvegicus	0-11
1377990-6	1992	These results support the hypothesis that the developmental change in responsiveness to T cell-independent polysaccharide antigens in humans is associated with maturation of the CD5- B cell subset.	Polysaccharides	107-121	CD5 molecule	Homo sapiens	178-181
1378017-6	1992	The binding of GMP-140 to primed T cells is not influenced by preactivation with phorbol 12-myristate 13-acetate, is almost completely abolished by pretreatment of T cells with neuraminidase or trypsin, and is also strongly inhibited by EDTA, the soluble sulfated glycans dextran sulfate, fucoidan, and heparin, but not by chondroitin sulfates.	Polysaccharides	264-271	selectin P	Homo sapiens	15-22
1640282-6	1992	After one or two doses, Hib polysaccharide conjugated to outer membrane protein complex of Neisseria meningitidis (PRP-OMP) was more immunogenic than Hib polysaccharide-tetanus toxoid conjugate (PRP-T), or Hib oligomers conjugated to the mutant diphtheria toxin CRM197 (HbOC) (p less than 0.001).	Polysaccharides	28-42	prion protein	Homo sapiens	115-118
1640282-6	1992	After one or two doses, Hib polysaccharide conjugated to outer membrane protein complex of Neisseria meningitidis (PRP-OMP) was more immunogenic than Hib polysaccharide-tetanus toxoid conjugate (PRP-T), or Hib oligomers conjugated to the mutant diphtheria toxin CRM197 (HbOC) (p less than 0.001).	Polysaccharides	28-42	prion protein	Homo sapiens	195-198
1530288-4	1992	PSK (a protein-bound polysaccharide preparation), IL-1 and Cepharanthin cured not only the right, but also the left, non-treated tumor in a double grafted tumor system.	Polysaccharides	21-35	TAO kinase 2	Mus musculus	0-3
21584543-3	1992	The endogenous TNF production was significantly enhanced by priming (pretreatment) with high molecular-weight lignins or polysaccharides, but not by phenylpropenoid precursors or partially hydrolyzed products of glucans.	Polysaccharides	121-136	tumor necrosis factor	Mus musculus	15-18
1624792-4	1992	Using purified human CRP it could be shown that CRP immobilized onto polystyrene surfaces or onto latex beads binds distinct plasma glycoproteins including IgG, asialofetuin, asialo-beta 2-glycoprotein I and, likewise, synthetic glycoproteins as a lectin, exhibiting binding specificity for terminal galactosyl residues of the glycoprotein glycans.	Polysaccharides	340-347	C-reactive protein	Homo sapiens	48-51
1378017-6	1992	The binding of GMP-140 to primed T cells is not influenced by preactivation with phorbol 12-myristate 13-acetate, is almost completely abolished by pretreatment of T cells with neuraminidase or trypsin, and is also strongly inhibited by EDTA, the soluble sulfated glycans dextran sulfate, fucoidan, and heparin, but not by chondroitin sulfates.	Polysaccharides	264-271	neuraminidase 1	Homo sapiens	177-190
1588147-0	1992	Maternal immunization with the capsular polysaccharide vaccine for Haemophilus influenzae type b. Maternal immunization with the capsular polysaccharide (PRP) vaccine of Haemophilus influenzae type b has been shown to extend the time that protective levels of maternal antibody are detected in infants.	Polysaccharides	138-152	prion protein	Homo sapiens	154-157
1378449-2	1992	P-selectin binds to a limited number of protease-sensitive sites on myeloid cells, but the protein(s) that carry the glycans recognized by P-selectin are unknown.	Polysaccharides	117-124	selectin P	Homo sapiens	0-10
1378449-2	1992	P-selectin binds to a limited number of protease-sensitive sites on myeloid cells, but the protein(s) that carry the glycans recognized by P-selectin are unknown.	Polysaccharides	117-124	selectin P	Homo sapiens	139-149
1378455-5	1992	Immunoglobulin G, A, and M (IgG, IgA and IgM) antibodies were all involved in the specific systemic response to P. aeruginosa lipid A, core, and the O polysaccharides.	Polysaccharides	151-166	CD79a molecule	Homo sapiens	33-36
1378455-8	1992	Antibodies detected in sputum were mainly anti-lipid A and anti-O polysaccharide antibodies of the IgG and IgA isotypes.	Polysaccharides	66-80	CD79a molecule	Homo sapiens	107-110
1376338-0	1992	Sulfated glycans directly interact with mouse Thy-1 and negatively regulate Thy-1-mediated adhesion of thymocytes to thymic epithelial cells.	Polysaccharides	9-16	thymus cell antigen 1, theta	Mus musculus	46-51
1376338-0	1992	Sulfated glycans directly interact with mouse Thy-1 and negatively regulate Thy-1-mediated adhesion of thymocytes to thymic epithelial cells.	Polysaccharides	9-16	thymus cell antigen 1, theta	Mus musculus	76-81
1376338-4	1992	In the present study, we aimed at evaluating the interaction of sulfated glycans with mouse Thy-1, as well as its consequence on Thy-1-mediated thymic lympho-epithelial cell interaction.	Polysaccharides	73-80	thymus cell antigen 1, theta	Mus musculus	92-97
1376338-6	1992	Sulfated glycans such as pentosan sulfate, dextran sulfate, and fucoidan were found to strongly inhibit the binding of Thy-1 to heparin.	Polysaccharides	9-16	thymus cell antigen 1, theta	Mus musculus	119-124
1376338-8	1992	Sulfated glycans (e.g., pentosan sulfate, assayed at a concentration of 50 micrograms/ml) completely blocked the Thy-1-dependent adhesion of T cells to a mouse thymic epithelial cell monolayer.	Polysaccharides	9-16	thymus cell antigen 1, theta	Mus musculus	113-118
1627608-12	1992	We conclude that structures of MCP glycans can differ between trophoblasts and other cell types.	Polysaccharides	35-42	CD46 molecule	Homo sapiens	31-34
1376338-10	1992	Our results suggest that sulfated glycans bind to a Thy-1 site distinct from that with which this molecule interacts with its heterophilic ligand.	Polysaccharides	34-41	thymus cell antigen 1, theta	Mus musculus	52-57
1563770-1	1992	Synthetic oligosaccharides derived from the capsular polysaccharide (PRP) of Haemophilus influenzae type b were conjugated to carrier proteins via a thioether linkage.	Polysaccharides	53-67	prion protein	Mus musculus	69-72
1577805-0	1992	A human lysosomal alpha-mannosidase specific for the core of complex glycans.	Polysaccharides	69-76	mannosidase alpha class 2B member 1	Homo sapiens	8-35
1373759-4	1992	The production of IFN-gamma by non-T cells in response to bacterial products, possibly capsular polysaccharides, may provide an explanation underlying the ability of TI antigens, which are unable to directly stimulate T cell-derived cytokines to induce Ig isotype switching.	Polysaccharides	96-111	interferon gamma	Mus musculus	18-27
1642754-1	1992	Mouse IgG3 subclass antibodies predominate in humoral responses to bacterial polysaccharide antigens.	Polysaccharides	77-91	Immunoglobulin heavy constant gamma 3	Mus musculus	6-10
1499028-0	1992	The polysaccharides of agricultural lupin seeds.	Polysaccharides	4-19	5'-nucleotidase, cytosolic IIIA	Homo sapiens	36-41
1569346-2	1992	C4B forms ester bonds more efficiently than C4A and so, in theory, is more likely than C4A to bind to polysaccharide capsules of encapsulated bacteria.	Polysaccharides	102-116	complement C4B (Chido blood group)	Homo sapiens	0-3
1569346-2	1992	C4B forms ester bonds more efficiently than C4A and so, in theory, is more likely than C4A to bind to polysaccharide capsules of encapsulated bacteria.	Polysaccharides	102-116	complement C4A (Rodgers blood group)	Homo sapiens	44-47
1569346-2	1992	C4B forms ester bonds more efficiently than C4A and so, in theory, is more likely than C4A to bind to polysaccharide capsules of encapsulated bacteria.	Polysaccharides	102-116	complement C4A (Rodgers blood group)	Homo sapiens	87-90
1573274-7	1992	Although the secretagogue and proteoglycanase activities of chymase are inhibited by most classes of mast cell granule-associated glycans, the amidolytic activity of chymase toward tripeptide 4-nitroanilide substrates is augmented.	Polysaccharides	130-137	chymase 1	Canis lupus familiaris	60-67
1499028-1	1992	The polysaccharides of the seeds of four species of agricultural lupin have been shown to comprise galactans, arabinogalactans, arabinans, rhamnogalacturonans, and galactoxyloglucans.	Polysaccharides	4-19	5'-nucleotidase, cytosolic IIIA	Homo sapiens	65-70
1516727-5	1992	Presumably, some advantages must accrue to the organism from this design, and one idea, that we have discussed previously, is that the polysaccharide functions as a "template" for the organisation of structural proteins in the ECM and for the binding and presentation of growth factors within the matrix polymer network.	Polysaccharides	135-149	multimerin 1	Homo sapiens	227-230
1551875-8	1992	These results indicate that the three materials that have been demonstrated by others to block HIV-1 infection in vitro, sulfated polysaccharides, certain CD4-derived synthetic peptides, and anti-V3 antibodies, may be acting through a common mechanism that includes binding to the V3 region of gp120 on HIV-1.	Polysaccharides	130-145	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	294-299
1555586-3	1992	Glycans from placental transferrin receptor were further characterized, after desialylation, by methylation analysis and, in part, by liquid secondary-ion mass spectrometry.	Polysaccharides	0-7	transferrin receptor	Homo sapiens	23-43
1555586-8	1992	Transferrin receptor from donor A carried predominantly diantennary and triantennary complex-type glycans, in part fucosylated at the innermost N-acetylglucosamine residue, in addition to small amounts of bisected and of incomplete diantennary species.	Polysaccharides	98-105	transferrin	Homo sapiens	0-11
1606356-8	1992	1H-NMR spectroscopy (400 MHz) of the glycan chains, alpha 6-sialylated in vitro, showed that the enzyme highly prefers the galactosyl residue at the Gal beta 1----4GlcNAc beta 1----2-Man alpha 1----3Man branch for attachment of the first mol of sialic acid into the diantennary glycans of desialylated hCG.	Polysaccharides	37-43	chorionic gonadotropin subunit beta 5	Homo sapiens	302-305
1606356-8	1992	1H-NMR spectroscopy (400 MHz) of the glycan chains, alpha 6-sialylated in vitro, showed that the enzyme highly prefers the galactosyl residue at the Gal beta 1----4GlcNAc beta 1----2-Man alpha 1----3Man branch for attachment of the first mol of sialic acid into the diantennary glycans of desialylated hCG.	Polysaccharides	278-285	chorionic gonadotropin subunit beta 5	Homo sapiens	302-305
1606356-1	1992	Human chorionic gonadotrophin (hCG) is a heterodimeric glycoprotein hormone consisting of an alpha- and a beta-subunit, both containing two N-linked, complex-type glycans.	Polysaccharides	163-170	chorionic gonadotropin subunit beta 5	Homo sapiens	31-34
1606356-3	1992	Initial rates of sialic acid incorporation into the desialylated glycans of hCG alpha and hCG beta in the heterodimer were higher with the alpha-subunit.	Polysaccharides	65-72	chorionic gonadotropin subunit beta 5	Homo sapiens	76-79
1582998-0	1992	Inhibition of autonomous human keratinocyte proliferation and amphiregulin mitogenic activity by sulfated polysaccharides.	Polysaccharides	106-121	amphiregulin	Homo sapiens	62-74
1556184-4	1992	In contrast, when anti-Gal bound to the capsular polysaccharide of a serum sensitive Serratia, #7, it increased ACP killing of this strain.	Polysaccharides	49-63	galanin and GMAP prepropeptide	Homo sapiens	23-26
1311348-11	1992	Treatment of IFN-gamma-stimulated eosinophils with phosphatidylinositol-specific phospholipase C reduced FcRIII expression, suggesting that, like neutrophils, eosinophils express the phosphatidylinositol glycan-linked form of this receptor.	Polysaccharides	204-210	interferon gamma	Homo sapiens	13-22
1311348-11	1992	Treatment of IFN-gamma-stimulated eosinophils with phosphatidylinositol-specific phospholipase C reduced FcRIII expression, suggesting that, like neutrophils, eosinophils express the phosphatidylinositol glycan-linked form of this receptor.	Polysaccharides	204-210	Fc gamma receptor IIIa	Homo sapiens	105-111
1552207-1	1992	Nearly one-half of infants immunized with Haemophilus influenzae b capsular polysaccharide (polyribosylribitol phosphate; PRP)-protein conjugate produce low-affinity antibody.	Polysaccharides	76-90	prion protein	Homo sapiens	122-125
1350932-13	1992	The major glycan is a typical plant modified-type structure, Man alpha 1-6(Xyl beta 1-2)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-3)GlcNAc.	Polysaccharides	10-16	adrenoceptor alpha 1D	Homo sapiens	65-74
1350932-13	1992	The major glycan is a typical plant modified-type structure, Man alpha 1-6(Xyl beta 1-2)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-3)GlcNAc.	Polysaccharides	10-16	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	79-87
1350932-13	1992	The major glycan is a typical plant modified-type structure, Man alpha 1-6(Xyl beta 1-2)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-3)GlcNAc.	Polysaccharides	10-16	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	79-85
1350932-13	1992	The major glycan is a typical plant modified-type structure, Man alpha 1-6(Xyl beta 1-2)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-3)GlcNAc.	Polysaccharides	10-16	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	92-98
1350932-13	1992	The major glycan is a typical plant modified-type structure, Man alpha 1-6(Xyl beta 1-2)Man beta 1-4GlcNAc beta 1-4(Fuc alpha 1-3)GlcNAc.	Polysaccharides	10-16	adrenoceptor alpha 1D	Homo sapiens	65-72
1627273-0	1992	Mimicking of superoxide dismutase activity by protein-bound polysaccharide of Coriolus versicolor QUEL, and oxidative stress relief for cancer patients.	Polysaccharides	60-74	superoxide dismutase 1	Homo sapiens	13-33
1627273-1	1992	The protein-bound polysaccharide of Coriolus versicolor QUEL (PS-K) has been found to express antioxidant activity as an "ion-radical scavenger" in diamine oxidation reactions.	Polysaccharides	18-32	TAO kinase 2	Homo sapiens	62-66
1582998-2	1992	In the present study, we demonstrate that sulfated polysaccharides other than heparin (low and high molecular weight dextran sulfates) also inhibit the AR-mediated autonomous proliferation of human keratinocytes.	Polysaccharides	51-66	amphiregulin	Homo sapiens	152-154
1582998-3	1992	Furthermore, sulfated polysaccharides such as high and low molecular weight dextran sulfates, heparan sulfate and, to a lesser extent, chondroitin sulfates B and C were also shown to be inhibitors of human keratinocyte-derived AR (k-d AR)-stimulated DNA synthesis in quiescent murine AKR-2B cell cultures.	Polysaccharides	22-37	amphiregulin	Homo sapiens	227-229
1582998-4	1992	Our results demonstrate that sulfation of polysaccharides is required for AR inhibitory activity, and that several sulfated polysaccharides (other than heparin) can act as inhibitors of AR-mediated autonomous proliferation in human epidermal keratinocytes and as inhibitors of k-d AR-mediated mitogenic activity in AKR-2B cells.	Polysaccharides	124-139	amphiregulin	Homo sapiens	186-188
1582998-4	1992	Our results demonstrate that sulfation of polysaccharides is required for AR inhibitory activity, and that several sulfated polysaccharides (other than heparin) can act as inhibitors of AR-mediated autonomous proliferation in human epidermal keratinocytes and as inhibitors of k-d AR-mediated mitogenic activity in AKR-2B cells.	Polysaccharides	124-139	amphiregulin	Homo sapiens	186-188
1536850-4	1992	Likewise, substitution of N-sulfate groups of heparin and low molecular weight heparin (fragmin) by acetyl or hexanoyl residues resulted in an almost complete inhibition of bFGF release by these polysaccharides.	Polysaccharides	195-210	fibroblast growth factor 2	Rattus norvegicus	173-177
1372283-0	1992	Activation of human natural killer cells by the protein-bound polysaccharide PSK independently of interferon and interleukin 2.	Polysaccharides	62-76	TAO kinase 2	Homo sapiens	77-80
1372283-1	1992	The protein-bound polysaccharide PSK was tested for the ability to activate human natural killer (NK) cells.	Polysaccharides	18-32	TAO kinase 2	Homo sapiens	33-36
1531473-0	1992	Induction of phosphatidylinositol-glycan-linked Fc gamma RIII in human monocytic THP-1 cells by transforming growth factor-beta 1 and retinoic acid.	Polysaccharides	34-40	Fc gamma receptor IIIa	Homo sapiens	48-61
1737787-8	1992	Rat lung CA IV was found to be relatively resistant to sodium dodecyl sulfate and to be anchored to membranes by a phosphatidylinositol-glycan linkage; both properties were found to be shared by other mammalian CA IVs.	Polysaccharides	136-142	carbonic anhydrase 4	Rattus norvegicus	9-14
1320301-4	1992	We also observed that heparin and other sulfated polysaccharides had an accelerating effect on thrombin cleavage of recombinant scu-PA. Their effect was concentration-dependent and then reversed at high levels.	Polysaccharides	49-64	prothrombin	Oryctolagus cuniculus	95-103
1531473-6	1992	These results indicated that TGF-beta 1 could induce phosphatidylinositol-glycan-linked Fc gamma RIII (Fc gamma RIII-I) in THP-1 cells in the presence of RA.	Polysaccharides	74-80	transforming growth factor beta 1	Homo sapiens	29-39
1531473-6	1992	These results indicated that TGF-beta 1 could induce phosphatidylinositol-glycan-linked Fc gamma RIII (Fc gamma RIII-I) in THP-1 cells in the presence of RA.	Polysaccharides	74-80	Fc gamma receptor IIIa	Homo sapiens	88-101
1531473-0	1992	Induction of phosphatidylinositol-glycan-linked Fc gamma RIII in human monocytic THP-1 cells by transforming growth factor-beta 1 and retinoic acid.	Polysaccharides	34-40	GLI family zinc finger 2	Homo sapiens	81-86
1531473-6	1992	These results indicated that TGF-beta 1 could induce phosphatidylinositol-glycan-linked Fc gamma RIII (Fc gamma RIII-I) in THP-1 cells in the presence of RA.	Polysaccharides	74-80	Fc gamma receptor IIIa	Homo sapiens	103-116
1531473-6	1992	These results indicated that TGF-beta 1 could induce phosphatidylinositol-glycan-linked Fc gamma RIII (Fc gamma RIII-I) in THP-1 cells in the presence of RA.	Polysaccharides	74-80	GLI family zinc finger 2	Homo sapiens	123-128
1730479-2	1992	The presence of immunoglobulin G (IgG), IgA, and IgM with specificities for capsular polysaccharide, lipopolysaccharide, and hemolysin was determined by enzyme-linked immunosorbent assay by using purified antigens.	Polysaccharides	85-99	IGG	Sus scrofa	16-32
1730479-2	1992	The presence of immunoglobulin G (IgG), IgA, and IgM with specificities for capsular polysaccharide, lipopolysaccharide, and hemolysin was determined by enzyme-linked immunosorbent assay by using purified antigens.	Polysaccharides	85-99	IGG	Sus scrofa	34-37
1531473-0	1992	Induction of phosphatidylinositol-glycan-linked Fc gamma RIII in human monocytic THP-1 cells by transforming growth factor-beta 1 and retinoic acid.	Polysaccharides	34-40	transforming growth factor beta 1	Homo sapiens	96-129
1346095-0	1992	Lipoprotein-associated coagulation inhibitor (LACI) is a cofactor for heparin: synergistic anticoagulant action between LACI and sulfated polysaccharides.	Polysaccharides	138-153	tissue factor pathway inhibitor	Homo sapiens	0-44
1346095-0	1992	Lipoprotein-associated coagulation inhibitor (LACI) is a cofactor for heparin: synergistic anticoagulant action between LACI and sulfated polysaccharides.	Polysaccharides	138-153	tissue factor pathway inhibitor	Homo sapiens	46-50
1730217-10	1992	The strong anticoagulant action of LW10082 is consistent with previous reports which show that the degree of sulfation is an important parameter for the catalytic effectiveness of sulfated polysaccharides on thrombin inhibition.	Polysaccharides	189-204	coagulation factor II, thrombin	Homo sapiens	208-216
1346095-12	1992	Many sulfated polysaccharides were also found to enhance the LACI-dependent inhibition of TF-induced clotting.	Polysaccharides	14-29	tissue factor pathway inhibitor	Homo sapiens	61-65
1346095-12	1992	Many sulfated polysaccharides were also found to enhance the LACI-dependent inhibition of TF-induced clotting.	Polysaccharides	14-29	coagulation factor III, tissue factor	Homo sapiens	90-92
1284853-6	1992	For MAG from adult rat brain, the binding of CSL is restricted to glycans of polypeptide chains which could be separated from the others according to their solubility properties.	Polysaccharides	66-73	myelin-associated glycoprotein	Rattus norvegicus	4-7
1279952-3	1992	(2) Heparin and its related polysaccharides stabilize bFGF and other growth factors.	Polysaccharides	28-43	fibroblast growth factor 2	Homo sapiens	54-58
1622733-0	1992	Immunomodulation by orally administered protein-bound polysaccharide PSK in patients with gastrointestinal cancer.	Polysaccharides	54-68	TAO kinase 2	Homo sapiens	69-72
1622733-1	1992	The present study was designed to assess the effects of the protein-bound polysaccharide PSK on the immunological status of patients with gastrointestinal cancer.	Polysaccharides	74-88	TAO kinase 2	Homo sapiens	89-92
1576211-0	1992	Molecular dynamics simulations of a monofucosylated biantennary glycan of the N-acetyllactosamine type: the human lactotransferrin glycan.	Polysaccharides	64-70	lactotransferrin	Homo sapiens	114-130
1576211-0	1992	Molecular dynamics simulations of a monofucosylated biantennary glycan of the N-acetyllactosamine type: the human lactotransferrin glycan.	Polysaccharides	131-137	lactotransferrin	Homo sapiens	114-130
1517528-1	1992	The effects of oral administration of antitumor polysaccharide SPR-901 (RBS), an alpha-1,3 branched alpha-1,6 glucan, on concanavalin A (Con A)-induced interleukin 2 (IL-2) production of splenocytes were studied.	Polysaccharides	48-62	interleukin 2	Mus musculus	152-165
1722400-4	1991	Binding of activated platelets to SLea or SLex was inhibited to various degrees in the presence of sulfated glycans, suggesting that sulfated glycans induce conformational change in the lectin domain of GMP-140 and modulates its binding affinity to SLea and SLex.	Polysaccharides	108-115	selectin P	Homo sapiens	203-210
1517528-0	1992	Augmentation of mitogen-induced interleukin 2 production by oral administration of polysaccharide SPR-901.	Polysaccharides	83-97	interleukin 2	Mus musculus	32-45
1517528-0	1992	Augmentation of mitogen-induced interleukin 2 production by oral administration of polysaccharide SPR-901.	Polysaccharides	83-97	sepiapterin reductase	Mus musculus	98-101
1560751-6	1992	Mice primed at birth and immunized at 8 days had a 100% survival and 90% of these mice had sterile blood cultures by 8 h. Mice primed and immunized with MCP all remained bacteremic at 24 h. These data indicate that the anti-Id 6F9 which mimics the capsular polysaccharide of group C meningococci is capable of inducing protective immunity in immunologically mature as well as immature animals.	Polysaccharides	257-271	complement component (3b/4b) receptor 1-like	Mus musculus	153-156
1472793-1	1992	The prognostic value of immunosuppressive acidic protein (IAP), which is known to suppress various immune responses in cancer patients, was studied in a prospective randomized trial of advanced gastric cancer patients, designed to evaluate the effect of PSK, a kind of biological response modifier with protein-bound polysaccharides.	Polysaccharides	317-332	islet amyloid polypeptide	Homo sapiens	24-56
1472793-1	1992	The prognostic value of immunosuppressive acidic protein (IAP), which is known to suppress various immune responses in cancer patients, was studied in a prospective randomized trial of advanced gastric cancer patients, designed to evaluate the effect of PSK, a kind of biological response modifier with protein-bound polysaccharides.	Polysaccharides	317-332	islet amyloid polypeptide	Homo sapiens	58-61
1339233-1	1992	We investigated the effect of PSK, a protein-bound polysaccharide obtained from Coriolus versicolor of basidiomycetes, on antitumor immunity in tumor-bearing mice.	Polysaccharides	51-65	TAO kinase 2	Mus musculus	30-33
1729468-2	1992	Starch, a polysaccharide composed of alpha 1,4-linked glucose units (amylose) and alpha 1,4-1,6-linked branched structure (amylopectin), is cleaved in the duodenal cavity by secreted pancreatic alpha-amylase to a disaccharide (maltose), trisaccharide (maltotriose), and branched alpha-dextrins.	Polysaccharides	10-24	amylase alpha 2A	Homo sapiens	183-207
1722400-0	1991	Selectin GMP-140 (CD62; PADGEM) binds to sialosyl-Le(a) and sialosyl-Le(x), and sulfated glycans modulate this binding.	Polysaccharides	89-96	selectin P	Homo sapiens	9-16
1722400-0	1991	Selectin GMP-140 (CD62; PADGEM) binds to sialosyl-Le(a) and sialosyl-Le(x), and sulfated glycans modulate this binding.	Polysaccharides	89-96	selectin P	Homo sapiens	18-22
1722400-4	1991	Binding of activated platelets to SLea or SLex was inhibited to various degrees in the presence of sulfated glycans, suggesting that sulfated glycans induce conformational change in the lectin domain of GMP-140 and modulates its binding affinity to SLea and SLex.	Polysaccharides	142-149	selectin P	Homo sapiens	203-210
1718585-7	1991	This is likely to be a core glycan since 3E1.2 reacts after treatment of the mucin with trifluoromethanesulfonic acid, which removes most backbone and peripheral carbohydrates.	Polysaccharides	28-34	LOC100508689	Homo sapiens	77-82
1937808-2	1991	The question addressed in this paper was whether the presence of the polysaccharide moiety on the LPS molecule had any bearing on this ability.	Polysaccharides	69-83	toll-like receptor 4	Mus musculus	98-101
1937808-6	1991	However, the presence of long-chain polysaccharides attached to the lipid moiety on the intact smooth bacterium was associated with a decreased ability to induce TNF.	Polysaccharides	36-51	tumor necrosis factor	Mus musculus	162-165
1657976-9	1991	Analysis of the size of cell surface complex-type glycopeptides before and after digestion with neuraminidase and endo-beta-galactosidase suggested an increased sialic acid density, an increase in the number and/or length of polylactosaminoglycan chains, and an increased branching of the glycans upon N-ras induction.	Polysaccharides	289-296	neuraminidase 1	Homo sapiens	96-109
1763970-4	1991	Under low shear stress conditions, substantial binding of AT to both high- and low-affinity heparin was observed, in relative quantities largely reflecting the proportion of these polysaccharide populations on the surface.	Polysaccharides	180-194	serpin family C member 1	Homo sapiens	58-60
1839024-0	1991	A protein-bound polysaccharide from Basidiomycetes enhances myosin phosphorylation but inhibits myosin ATPase activity: studies with a crude actomyosin preparation of chicken gizzard smooth muscle.	Polysaccharides	16-30	myosin, heavy chain 15	Gallus gallus	60-66
1839024-0	1991	A protein-bound polysaccharide from Basidiomycetes enhances myosin phosphorylation but inhibits myosin ATPase activity: studies with a crude actomyosin preparation of chicken gizzard smooth muscle.	Polysaccharides	16-30	myosin, heavy chain 15	Gallus gallus	96-102
1804533-0	1991	Partial structure of an anti-ulcer pectic polysaccharide from the roots of Bupleurum falcatum L. Methylation analysis of a pectic polysaccharide (Bupleuran 2IIc) with anti-ulcer activity, isolated from the roots of Bupleurum falcatum L., revealed (1----4)-linked alpha-GalA together with small proportions of 2,4- and 3,4-linked GalA, and variously linked neutral sugars.	Polysaccharides	42-56	galactosidase alpha	Homo sapiens	269-273
1804533-0	1991	Partial structure of an anti-ulcer pectic polysaccharide from the roots of Bupleurum falcatum L. Methylation analysis of a pectic polysaccharide (Bupleuran 2IIc) with anti-ulcer activity, isolated from the roots of Bupleurum falcatum L., revealed (1----4)-linked alpha-GalA together with small proportions of 2,4- and 3,4-linked GalA, and variously linked neutral sugars.	Polysaccharides	42-56	galactosidase alpha	Homo sapiens	329-333
1757114-4	1991	In general, polysaccharide conjugates induced higher anti-PS4 IgG antibody titers than oligosaccharide conjugates.	Polysaccharides	12-26	taste 2 receptor member 18 pseudogene	Homo sapiens	58-61
1663364-7	1991	Indeed, the increased reactivity after sialidase treatment of ovine submaxillary mucin suggests the lectin reacts with peptide-linked N-acetylgalactosamine (GalNAc), since more than 98% of the glycan chains attached to this mucin are sialylated GalNAc.	Polysaccharides	193-199	LOC100508689	Homo sapiens	81-86
1663364-8	1991	The binding of SSA-M to sialidase-treated porcine mucin was inhibited strongly by GalNAc and disaccharides containing galactose (lactose, melibiose, and N-acetyllactosamine) but not by free galactose (Gal), suggesting that the glycan for optimum binding is Gal beta(1-3)GalNAc.	Polysaccharides	227-233	LOC100508689	Homo sapiens	50-55
1895386-4	1991	Characterization of mutant gene products by radioimmunoprecipitation confirmed that glycosylation occurs at all eight consensus signals in gp70 and that gs2 carries an endoglycosidase H-sensitive glycan.	Polysaccharides	196-202	patatin like phospholipase domain containing 4	Homo sapiens	153-156
1911434-0	1991	Hormone-associated variation of the glycan microheterogeneity pattern of human sex steroid-binding protein (hSBP).	Polysaccharides	36-42	sex hormone binding globulin	Homo sapiens	79-106
1911434-0	1991	Hormone-associated variation of the glycan microheterogeneity pattern of human sex steroid-binding protein (hSBP).	Polysaccharides	36-42	selenium binding protein 1	Homo sapiens	108-112
1911434-6	1991	An explanation for these differences is given and the role of the glycan moiety of hSBP is discussed.	Polysaccharides	66-72	selenium binding protein 1	Homo sapiens	83-87
1954031-0	1991	Activation and subsequent degradation of proacrosin is mediated by zona pellucida glycoproteins, negatively charged polysaccharides, and DNA.	Polysaccharides	116-131	acrosin	Homo sapiens	41-51
1909736-0	1991	Human IgA1 blockade of IgG-initiated lysis of Neisseria meningitidis is a function of antigen-binding fragment binding to the polysaccharide capsule.	Polysaccharides	126-140	immunoglobulin heavy constant alpha 1	Homo sapiens	6-10
1909736-1	1991	We have recently shown that human IgA1 can initiate lysis of group C Neisseria meningitidis via the classical C pathway when bound to specific outer membrane proteins, but that IgA1 can also function as a blocking antibody when bound to the polysaccharide capsule of meningococci.	Polysaccharides	241-255	immunoglobulin heavy constant alpha 1	Homo sapiens	34-38
1909736-1	1991	We have recently shown that human IgA1 can initiate lysis of group C Neisseria meningitidis via the classical C pathway when bound to specific outer membrane proteins, but that IgA1 can also function as a blocking antibody when bound to the polysaccharide capsule of meningococci.	Polysaccharides	241-255	immunoglobulin heavy constant alpha 1	Homo sapiens	177-181
1909736-10	1991	Absorption of the IgA1 and IgG with alum-bound group C polysaccharide completely removed blocking and lytic activity, respectively, indicating that both the blocking IgA1 and the lytic IgG were specific for the group C capsule.	Polysaccharides	55-69	immunoglobulin heavy constant alpha 1	Homo sapiens	18-22
1909736-10	1991	Absorption of the IgA1 and IgG with alum-bound group C polysaccharide completely removed blocking and lytic activity, respectively, indicating that both the blocking IgA1 and the lytic IgG were specific for the group C capsule.	Polysaccharides	55-69	immunoglobulin heavy constant alpha 1	Homo sapiens	166-170
1909736-11	1991	Blocking by IgA1 was a linear function of the polysaccharide Ag-binding capacity (ABC) ratio of blocking IgA1 to lytic IgG.	Polysaccharides	46-60	immunoglobulin heavy constant alpha 1	Homo sapiens	12-16
1909736-11	1991	Blocking by IgA1 was a linear function of the polysaccharide Ag-binding capacity (ABC) ratio of blocking IgA1 to lytic IgG.	Polysaccharides	46-60	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	82-85
1909736-11	1991	Blocking by IgA1 was a linear function of the polysaccharide Ag-binding capacity (ABC) ratio of blocking IgA1 to lytic IgG.	Polysaccharides	46-60	immunoglobulin heavy constant alpha 1	Homo sapiens	105-109
1909736-15	1991	We conclude that IgA1, when bound to the group C polysaccharide capsule, can block IgG-initiated lysis of group C meningococci through either the classical or the alternative pathway before or after the organism is exposed to IgG, and that blockade is an Fc-independent event.	Polysaccharides	49-63	immunoglobulin heavy constant alpha 1	Homo sapiens	17-21
1768050-1	1991	When mouse resident peritoneal macrophages were cultured with PSK (Krestin), a protein-bound polysaccharide extracted from Coriolus versicolor, they became enlarged and elongated and expressed higher NBT-reducing activity.	Polysaccharides	93-107	TAO kinase 2	Mus musculus	62-65
1764990-14	1991	Polysaccharide analysis by glycosidase digestion and lectin binding indicates that neurothelin is highly glycosylated.	Polysaccharides	0-14	basigin (Ok blood group)	Gallus gallus	83-94
1713609-5	1991	In contrast, only two of these mAb were able to completely block the binding of phosphomannan monoester core complex from the yeast Hansenula holstii cell wall (PPME), a phosphomannan monoester core polysaccharide that serves as a soluble model of the natural ligand of LAM-1.	Polysaccharides	199-213	selectin L	Homo sapiens	270-275
1938599-1	1991	The protein-bound polysaccharide PSK was tested for the ability to induce in vitro autologous tumor killing (ATK) activity in human cancer patients.	Polysaccharides	18-32	TAO kinase 2	Homo sapiens	33-36
2058604-1	1991	We studied the immunologic responsiveness to Haemophilus influenzae type b capsular polysaccharide-Neisseria meningitidis group b outer membrane protein conjugate vaccine (PRP-NOMP) in children 2 to 42 months of age with vaccine dosages containing 7.5, 15, or 30 micrograms of PRP.	Polysaccharides	84-98	prion protein	Homo sapiens	172-175
2071579-13	1991	Dissociation of the SAP.C4BP complex by sulfated polysaccharides such as heparin may be a physiological response that could be important during tissue damage or complement activation.	Polysaccharides	49-64	amyloid P component, serum	Homo sapiens	20-23
2071579-13	1991	Dissociation of the SAP.C4BP complex by sulfated polysaccharides such as heparin may be a physiological response that could be important during tissue damage or complement activation.	Polysaccharides	49-64	complement component 4 binding protein alpha	Homo sapiens	24-28
1853566-13	1991	Heterogeneity existed in the extent of processing of these glycans among individual E1 and E2 molecules.	Polysaccharides	59-66	small nucleolar RNA, H/ACA box 73A	Homo sapiens	84-93
1711566-7	1991	We conclude that the unresponsiveness of mice with the xid defect to polysaccharide antigens can not attributed to a failure to express the nine VH gene families that we examined.	Polysaccharides	69-83	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	55-58
1959932-3	1991	P3X63Ag8 analogous glycan of the IgG2b secreted by Sp2/HLBu.	Polysaccharides	19-25	Sp2 transcription factor	Homo sapiens	51-54
1715541-4	1991	The second channel tested, formed from a polysaccharide called chitosan, was prepared with NGF and laminin in the channel walls and provided a sustained release of NGF.	Polysaccharides	41-55	nerve growth factor	Mus musculus	91-94
1715541-4	1991	The second channel tested, formed from a polysaccharide called chitosan, was prepared with NGF and laminin in the channel walls and provided a sustained release of NGF.	Polysaccharides	41-55	nerve growth factor	Mus musculus	164-167
1802023-0	1991	A protein-bound polysaccharide immunomodulator, PSK, does not suppress the conversion from 1-(2-tetrahydrofuryl)-5-fluorouracil to 5-fluorouracil in patients with gastric cancer.	Polysaccharides	16-30	TAO kinase 2	Homo sapiens	48-51
1710632-8	1991	However, deficiency of the CD4+ CDw29+ helper-inducer or "memory" cells may contribute to the impaired helper function for B cell-induced protective antibody synthesis to bacterial capsular polysaccharides found in this disease.	Polysaccharides	190-205	CD4 molecule	Homo sapiens	27-30
2051173-2	1991	One of them, N-CAM120, has been shown to be anchored to the membranes by a complex glycan-phosphatidylinositol group and to be releasable, under soluble form, by the bacterial enzyme phosphatidylinositol-phospholipase C. We used the C6 rat astrocytoma cell line expressing both N-CAM120 and the transmembrane isoform N-CAM140 as a model system.	Polysaccharides	83-89	neural cell adhesion molecule 1	Rattus norvegicus	13-18
1711034-4	1991	The lectin shows highest affinity for a tri-antennary glycan carrying Gal beta 1----4GlcNAc substituents on C-2 and C-4 of Man alpha 1----3 and C-2 of Man alpha 1----6 core residues.	Polysaccharides	54-60	complement C4A (Rodgers blood group)	Homo sapiens	116-139
1711034-4	1991	The lectin shows highest affinity for a tri-antennary glycan carrying Gal beta 1----4GlcNAc substituents on C-2 and C-4 of Man alpha 1----3 and C-2 of Man alpha 1----6 core residues.	Polysaccharides	54-60	complement C2	Homo sapiens	144-167
1710238-1	1991	The CD59 Ag is a 20-kDa protein that is widely expressed on most leukocytes and RBC, is coupled to the membrane by a phosphatidylinositol-glycan anchoring structure, plays a role in cell interaction between monocytes and T cells, and also functions as an inhibitor of cytolysis by the terminal C components C5b-9.	Polysaccharides	138-144	CD59 molecule (CD59 blood group)	Homo sapiens	4-8
1654600-1	1991	We examined the effects of polysaccharides on t-PA mediated plasminogen activation using single-chain tissue plasminogen activator (sct-PA) and two-chain tissue plasminogen activator (tct-PA).	Polysaccharides	27-42	plasminogen activator, tissue type	Homo sapiens	46-50
1896524-1	1991	The acidic polysaccharide fraction (F-5-2) from "Juzen-Taiho-To" (TJ-48), a Kampo (Japanese herbal) medicine prepared by decocting a prescription of 10 kinds of herbs, has potent mitogenic activity.	Polysaccharides	11-25	MARCKS like 1	Homo sapiens	36-41
1891953-1	1991	Haemophilus influenzae type b (Hib) conjugate vaccines dramatically improve the immunogenicity against the capsular polysaccharide (PRP) of Hib.	Polysaccharides	116-130	prion protein	Homo sapiens	132-135
1896966-6	1991	From these results, it was suggested that thrombin decreased GAG in the endothelial cell layer through an suppression of formation of polysaccharide chains rather than that of core protein.	Polysaccharides	134-148	coagulation factor II, thrombin	Bos taurus	42-50
1871720-8	1991	Both vWf binding and platelet adhesion to sulfatides can be inhibited by the sulfated polysaccharide dextran sulfate at low concentration, fucoidan at high concentrations, but not by heparin, fibrinogen, fibronectin, or the synthetic peptides Gly-Arg-Gly-Asp-Ser-Pro or Gly-Arg-Gly-Glu-Ser-Pro.	Polysaccharides	86-100	von Willebrand factor	Homo sapiens	5-8
1871720-8	1991	Both vWf binding and platelet adhesion to sulfatides can be inhibited by the sulfated polysaccharide dextran sulfate at low concentration, fucoidan at high concentrations, but not by heparin, fibrinogen, fibronectin, or the synthetic peptides Gly-Arg-Gly-Asp-Ser-Pro or Gly-Arg-Gly-Glu-Ser-Pro.	Polysaccharides	86-100	fibronectin 1	Homo sapiens	204-215
1652426-2	1991	Previous work has shown that proacrosin, a protein found within the acrosome of mammalian spermatozoa, binds non-enzymatically to zona pellucida glycoproteins (ZPGPs) that surround the egg and that this binding can be inhibited by sulphated polysaccharides such as fucoidan.	Polysaccharides	241-256	acrosin	Homo sapiens	29-39
2007588-9	1991	The results thus suggest that heparin promotes the encounter of thrombin and AT primarily by approximating the proteinase and inhibitor on the polysaccharide surface.	Polysaccharides	143-157	coagulation factor II, thrombin	Homo sapiens	64-72
2054155-5	1991	However, there was a moderate rise in the proportion of fucosylated transferrin molecules (fucosylation index) and a slight decrease in the transferrin fraction bearing a tetrasialylated biantennary glycan.	Polysaccharides	199-205	transferrin	Rattus norvegicus	140-151
1826897-6	1991	Subsequently, we showed that PS complexed with C3d can be recognized by complement receptor type 2 that is expressed on B cells.	Polysaccharides	29-31	endogenous retrovirus group K member 13	Homo sapiens	47-50
1826897-6	1991	Subsequently, we showed that PS complexed with C3d can be recognized by complement receptor type 2 that is expressed on B cells.	Polysaccharides	29-31	complement C3d receptor 2	Homo sapiens	72-98
2016797-0	1991	Activation by the protein-bound polysaccharide PSK (krestin) of cytotoxic lymphocytes that act on fresh autologous tumor cells and T24 human urinary bladder transitional carcinoma cell line in patients with urinary bladder cancer.	Polysaccharides	32-46	TAO kinase 2	Homo sapiens	47-50
2016797-1	1991	PSK, a protein-bound polysaccharide Kureha, was tested for its ability to modulate the cytotoxicity of lymphocytes that act on autologous tumor cells and T24 human urinary bladder tumor cells in urinary bladder cancer patients in a 6-h 51Cr release assay.	Polysaccharides	21-35	TAO kinase 2	Homo sapiens	0-3
1902106-1	1991	We have developed an assay method for activin-binding protein, which exploits its high affinity for sulfated polysaccharides.	Polysaccharides	109-124	follistatin	Rattus norvegicus	38-61
2015821-0	1991	Structure determination of the glycans of human-serum alpha 1-antichymotrypsin using 1H-NMR spectroscopy and deglycosylation by N-glycanase.	Polysaccharides	31-38	serpin family A member 3	Homo sapiens	54-78
2015821-7	1991	Moreover our results show that the peak 1 contains four triantennary glycans, the peak 2 three triantennary and one diantennary glycans while the bound peaks 3 + 4 possess, on average, about one triantennary and three diantennary glycans per molecule.	Polysaccharides	69-76	pseudopodium enriched atypical kinase 1	Homo sapiens	35-41
2015821-7	1991	Moreover our results show that the peak 1 contains four triantennary glycans, the peak 2 three triantennary and one diantennary glycans while the bound peaks 3 + 4 possess, on average, about one triantennary and three diantennary glycans per molecule.	Polysaccharides	128-135	pseudopodium enriched atypical kinase 1	Homo sapiens	35-41
2015821-7	1991	Moreover our results show that the peak 1 contains four triantennary glycans, the peak 2 three triantennary and one diantennary glycans while the bound peaks 3 + 4 possess, on average, about one triantennary and three diantennary glycans per molecule.	Polysaccharides	128-135	pseudopodium enriched atypical kinase 1	Homo sapiens	35-41
1676899-3	1991	Action mechanisms of a newly synthesized polysaccharide, curdlan sulfate (CRDS), on human immunodeficiency virus type 1 (HIV-1) infection were investigated in vitro using syncytium formation microassay and p24 antigen capture enzyme-linked immunosorbent assay.	Polysaccharides	41-55	transmembrane p24 trafficking protein 2	Homo sapiens	206-209
1893492-0	1991	Studies on an enzymatically synthesized antitumor polysaccharide SPR-901.	Polysaccharides	50-64	sepiapterin reductase	Mus musculus	65-68
1893492-1	1991	An antitumor polysaccharide SPR-901 was found in a fermented broth of a kind of lactic acid bacteria isolated from rice bran.	Polysaccharides	13-27	sepiapterin reductase	Mus musculus	28-31
1893492-7	1991	These properties of SPR-901 were identical to those of RON, which was obtained from rice bran, therefore we concluded that these two polysaccharides were the same substance.	Polysaccharides	133-148	sepiapterin reductase	Mus musculus	20-23
1856676-5	1991	After a temperature shift-up a cdc30-bearing strain had cell cycle arrested and contained only 8% of the polysaccharide in the wild-type.	Polysaccharides	105-119	glucose-6-phosphate isomerase	Saccharomyces cerevisiae S288C	31-36
1706335-0	1991	GMP-140 binding to neutrophils is inhibited by sulfated glycans.	Polysaccharides	56-63	selectin P	Homo sapiens	0-7
1706335-7	1991	Since this sulfated glycan specificity is identical to that previously reported by us for GMP-140, the present results suggest that the sulfated glycan binding site and the neutrophil receptor binding site on GMP-140 are either identical or proximal.	Polysaccharides	20-26	selectin P	Homo sapiens	209-216
1706335-7	1991	Since this sulfated glycan specificity is identical to that previously reported by us for GMP-140, the present results suggest that the sulfated glycan binding site and the neutrophil receptor binding site on GMP-140 are either identical or proximal.	Polysaccharides	145-151	selectin P	Homo sapiens	90-97
1706335-7	1991	Since this sulfated glycan specificity is identical to that previously reported by us for GMP-140, the present results suggest that the sulfated glycan binding site and the neutrophil receptor binding site on GMP-140 are either identical or proximal.	Polysaccharides	145-151	selectin P	Homo sapiens	209-216
1995952-1	1991	The mechanism of the antiviral activity of sulfated polysaccharides on human immunodeficiency virus type 1 (HIV-1) was investigated by determining the effect of dextran sulfate on the binding of CD4 and several anti-gp120 monoclonal antibodies to both recombinant and cell surface gp120.	Polysaccharides	52-67	CD4 molecule	Homo sapiens	195-198
1848407-3	1991	This evidence suggests that LPL may be bound ionically to heparan sulfate proteoglycans that are covalently linked to the cell surface of cardiac myocytes by a phosphatidylinositol-glycan membrane anchor; a second pool of LPL may also be bound to proteoglycans attached directly to the myocardial cell surface.	Polysaccharides	80-86	lipoprotein lipase	Rattus norvegicus	28-31
1848407-3	1991	This evidence suggests that LPL may be bound ionically to heparan sulfate proteoglycans that are covalently linked to the cell surface of cardiac myocytes by a phosphatidylinositol-glycan membrane anchor; a second pool of LPL may also be bound to proteoglycans attached directly to the myocardial cell surface.	Polysaccharides	80-86	lipoprotein lipase	Rattus norvegicus	222-225
1999142-0	1991	Significance of the glycan moiety of the rat ovarian luteinizing hormone/chorionic gonadotropin (CG) receptor and human CG for receptor-hormone interaction.	Polysaccharides	20-26	chorionic gonadotropin subunit beta 5	Homo sapiens	97-99
1999142-1	1991	The role of the glycan moiety of the rat ovarian LH/CG receptor and human CG (hCG) in high-affinity receptor-hormone interaction was investigated by cross-linking and quantitative binding experiments.	Polysaccharides	16-22	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	49-63
1999142-1	1991	The role of the glycan moiety of the rat ovarian LH/CG receptor and human CG (hCG) in high-affinity receptor-hormone interaction was investigated by cross-linking and quantitative binding experiments.	Polysaccharides	16-22	chorionic gonadotropin subunit beta 5	Homo sapiens	52-54
1999142-1	1991	The role of the glycan moiety of the rat ovarian LH/CG receptor and human CG (hCG) in high-affinity receptor-hormone interaction was investigated by cross-linking and quantitative binding experiments.	Polysaccharides	16-22	chorionic gonadotropin subunit beta 5	Homo sapiens	78-81
2064356-0	1991	Induction of immunopotentiation activity by a protein-bound polysaccharide, PSK (review).	Polysaccharides	60-74	TAO kinase 2	Mus musculus	76-79
2064356-1	1991	A protein-bound polysaccharide, PSK, extracted from the mycelium of Coriolus versicolor (Fr.)	Polysaccharides	16-30	TAO kinase 2	Mus musculus	32-35
1995952-1	1991	The mechanism of the antiviral activity of sulfated polysaccharides on human immunodeficiency virus type 1 (HIV-1) was investigated by determining the effect of dextran sulfate on the binding of CD4 and several anti-gp120 monoclonal antibodies to both recombinant and cell surface gp120.	Polysaccharides	52-67	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	216-221
1995952-1	1991	The mechanism of the antiviral activity of sulfated polysaccharides on human immunodeficiency virus type 1 (HIV-1) was investigated by determining the effect of dextran sulfate on the binding of CD4 and several anti-gp120 monoclonal antibodies to both recombinant and cell surface gp120.	Polysaccharides	52-67	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	281-286
1656816-9	1991	However, while this binding is sufficient for TM to promote the activation of PC by thrombin, the inhibition by TM of thrombin-induced fibrinogen clotting and factor V activation requires the interaction of thrombin at a secondary site with the polysaccharide chain of TM.	Polysaccharides	245-259	prothrombin	Oryctolagus cuniculus	118-126
1877990-0	1991	Charge forms of serum and whey transferrin in rat differ in the sialic acid content of their glycan chains: immunological implications.	Polysaccharides	93-99	transferrin	Rattus norvegicus	31-42
1713439-5	1991	The studies with radiolabeled ASF virions suggest that the sulfated polysaccharides inhibit virus adsorption.	Polysaccharides	68-83	arylsulfatase F	Homo sapiens	30-33
1656816-9	1991	However, while this binding is sufficient for TM to promote the activation of PC by thrombin, the inhibition by TM of thrombin-induced fibrinogen clotting and factor V activation requires the interaction of thrombin at a secondary site with the polysaccharide chain of TM.	Polysaccharides	245-259	prothrombin	Oryctolagus cuniculus	118-126
1656816-10	1991	This interaction with the polysaccharide chain (which carries a highly sulfated trisaccharide at the non-reducing terminus) leads to the inhibition of the procoagulant functions of TM-bound thrombin towards fibrinogen and factor V as well as an increased reactivity of the enzyme with ATIII.	Polysaccharides	26-40	prothrombin	Oryctolagus cuniculus	190-198
1786200-0	1991	The augmentative effect of a protein-bound polysaccharide (PSK) on tumoricidal activity of the soluble factor produced by a streptococcal preparation (OK-432)-activated macrophages.	Polysaccharides	43-57	TAO kinase 2	Mus musculus	59-62
2036001-2	1991	The cell-associated enzyme activities needed to hydrolyze both substrates (amylase, arabinogalactanase, alpha-glucosidase, beta-galactosidase, and alpha-arabinofuranosidase) were variously influenced by growth rate and polysaccharide availability but were detected under all growth conditions tested.	Polysaccharides	219-233	glycoside hydrolase family 97 protein	Bacteroides ovatus	104-121
2036001-2	1991	The cell-associated enzyme activities needed to hydrolyze both substrates (amylase, arabinogalactanase, alpha-glucosidase, beta-galactosidase, and alpha-arabinofuranosidase) were variously influenced by growth rate and polysaccharide availability but were detected under all growth conditions tested.	Polysaccharides	219-233	beta-galactosidase	Bacteroides ovatus	123-141
1786200-1	1991	The enhancement of antitumor activities of the tumoricidal soluble factor (SF) from a streptococcal preparation (OK-432)-activated macrophages by the pretreatment with a protein-bound polysaccharide (PSK) was investigated in tumor-bearing mice.	Polysaccharides	184-198	TAO kinase 2	Mus musculus	200-203
1901030-1	1991	PSK, a protein-bound polysaccharide, has been widely used for cancer immunotherapy in Japan.	Polysaccharides	21-35	TAO kinase 2	Homo sapiens	0-3
1651300-10	1991	However, TN may, by its specific binding to kringle 4 of plasminogen and its high affinity for sulphated polysaccharides, add to the understanding of how plasminogen activation is modulated at the local extracellular level.	Polysaccharides	105-120	C-type lectin domain family 3 member B	Homo sapiens	9-11
1364373-5	1991	Four of six were acidic polysaccharides of sea weed origin and one was a well-known anti HIV chemical whose anti-HIV activity has not been reported.	Polysaccharides	24-39	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	43-46
2226466-10	1990	Thus, while catalysis of thrombin inhibition is a more effective pathway than catalysis of factor Xa inhibition for delaying prothrombin activation, the simultaneous catalysis of thrombin and factor Xa inhibition can synergistically improve the ability of a sulfated polysaccharide to delay prothrombin activation.	Polysaccharides	267-281	coagulation factor II, thrombin	Homo sapiens	25-33
1667038-2	1991	The antigenicity of Hib is related to its capsular polysaccharide (polyribosyl-ribitol-phosphate or PRP) which is at the origin of the production of bactericide anti-PRP antibodies.	Polysaccharides	51-65	prion protein	Homo sapiens	100-103
1667038-2	1991	The antigenicity of Hib is related to its capsular polysaccharide (polyribosyl-ribitol-phosphate or PRP) which is at the origin of the production of bactericide anti-PRP antibodies.	Polysaccharides	51-65	prion protein	Homo sapiens	166-169
2213021-2	1990	Therefore, we carried out quantitative and qualitative analyses of glycosaminoglycans (GAGs), the polysaccharide moiety of proteoglycans, during neuritogenesis in PC12 cells that is induced by nerve growth factor (NGF).	Polysaccharides	98-112	nerve growth factor	Rattus norvegicus	193-212
2213021-2	1990	Therefore, we carried out quantitative and qualitative analyses of glycosaminoglycans (GAGs), the polysaccharide moiety of proteoglycans, during neuritogenesis in PC12 cells that is induced by nerve growth factor (NGF).	Polysaccharides	98-112	nerve growth factor	Rattus norvegicus	214-217
1987032-0	1991	Murine macrophage interleukin-1 release by capsularlike serotype-specific polysaccharide antigens of Actinobacillus actinomycetemcomitans.	Polysaccharides	74-88	interleukin 1 complex	Mus musculus	18-31
1987032-6	1991	The IL-1-releasing ability of serotype a and c antigens was enhanced by deacetylation of both polysaccharides, suggesting that acetyl groups of these antigens might hinder the interaction between the antigens and macrophages.	Polysaccharides	94-109	interleukin 1 complex	Mus musculus	4-8
1749590-5	1991	On the contrary, combined administration of protein-bound polysaccharide (PSK) and 1-(2-tetrahydrofuryl)-5-fluorouracil showed no inhibitory effect on these activities.	Polysaccharides	58-72	TAO kinase 2	Mus musculus	74-77
2253681-0	1990	Low IgG2 and polysaccharide response in a T cell receptor expression defect.	Polysaccharides	13-27	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	42-57
2226466-10	1990	Thus, while catalysis of thrombin inhibition is a more effective pathway than catalysis of factor Xa inhibition for delaying prothrombin activation, the simultaneous catalysis of thrombin and factor Xa inhibition can synergistically improve the ability of a sulfated polysaccharide to delay prothrombin activation.	Polysaccharides	267-281	coagulation factor X	Homo sapiens	192-201
2079334-0	1990	Chromotropic character of bacterial acidic polysaccharides: Part III--Interaction of cationic dye pinacyanol chloride with Klebsiella K15 capsular polysaccharide.	Polysaccharides	43-58	keratin 15	Homo sapiens	134-137
2145267-4	1990	The glycan structure is identical to the conserved glycan core regions of the GPI anchor of Trypanosoma brucei variant surface glycoprotein and rat brain Thy-1 antigen, supporting the notion that this portion of GPIs are highly conserved.	Polysaccharides	4-10	Thy-1 cell surface antigen	Rattus norvegicus	154-167
2079334-1	1990	Interaction of cationic dye pinacyanol chloride with the acidic capsular polysaccharide isolated from Klebsiella serotype K15 has been investigated by spectral measurements.	Polysaccharides	73-87	keratin 15	Homo sapiens	122-125
2123978-6	1990	Results showed that antigens on the different stages of the parasite life cycle have a qualitative influence on the antibody response to the larval surface, and that T-independent type 2 polysaccharides, particularly abundant in egg, exhibit antigen-directed isotype restriction in the form of IgM and IgG3 antibodies.	Polysaccharides	187-202	Immunoglobulin heavy constant gamma 3	Mus musculus	302-306
2292586-3	1990	Affinity chromatography of the sulfated products on antithrombin III-Sepharose gel indicated that the polysaccharide acquired some affinity for the protein following the sulfation, as shown by the increase in the proportion of the high-affinity heparin fraction (%) from 1.1 to 6.7.	Polysaccharides	102-116	serpin family C member 1	Homo sapiens	52-68
2292586-4	1990	Biological examination of these products indicated that sulfation at natural positions along with the polysaccharide chain resulted in significant increases in all the activities (blood anti-clotting, anti-Factor IIa, and anti-Factor Xa), and in the strength of intrinsic fluorescence of antithrombin III.	Polysaccharides	102-116	coagulation factor X	Homo sapiens	227-236
2292586-4	1990	Biological examination of these products indicated that sulfation at natural positions along with the polysaccharide chain resulted in significant increases in all the activities (blood anti-clotting, anti-Factor IIa, and anti-Factor Xa), and in the strength of intrinsic fluorescence of antithrombin III.	Polysaccharides	102-116	serpin family C member 1	Homo sapiens	288-304
2241288-9	1990	In conclusion, it was found that exposure to pharyngeal infection with group A beta haemolytic streptococci may lead to acute rheumatic fever in those with an inherited recessive gene responsible for high responsiveness to the streptococcal polysaccharide antigen of the cell wall.	Polysaccharides	241-255	amyloid beta precursor protein	Homo sapiens	77-83
2235187-4	1990	Antibody to the polysaccharide capsule of Hib (PRP) was measured by radioimmunoassay.	Polysaccharides	16-30	prion protein	Homo sapiens	47-50
1974403-0	1990	Sulfated polysaccharides prevent human leukocyte elastase-induced acute lung injury and emphysema in hamsters.	Polysaccharides	9-24	elastase, neutrophil expressed	Homo sapiens	33-57
2169242-0	1990	Functional role of the polysaccharide component of rabbit thrombomodulin proteoglycan.	Polysaccharides	23-37	thrombomodulin	Oryctolagus cuniculus	58-72
2169242-2	1990	Previous work has indicated that (rabbit) TM is a proteoglycan that contains a single polysaccharide chain, tentatively identified as a sulphated galactosaminoglycan, and furthermore suggested that this component may be functionally related to additional anticoagulant activities expressed by the TM molecule [Bourin, Ohlin, Lane, Stenflo &amp; Lindahl (1988) J. Biol.	Polysaccharides	86-100	thrombomodulin	Oryctolagus cuniculus	42-44
2169242-9	1990	It is concluded that the inhibitory effect of TM on Factor V activation also depends on the presence of the polysaccharide component on the TM molecule.	Polysaccharides	108-122	thrombomodulin	Oryctolagus cuniculus	46-48
2169242-9	1990	It is concluded that the inhibitory effect of TM on Factor V activation also depends on the presence of the polysaccharide component on the TM molecule.	Polysaccharides	108-122	thrombomodulin	Oryctolagus cuniculus	140-142
1974403-1	1990	Studies were designed to explore the possibility that sulfated polysaccharides had the potential to prevent human leukocyte elastase (HLE)-induced lung injury.	Polysaccharides	63-78	elastase, neutrophil expressed	Homo sapiens	108-132
1974403-1	1990	Studies were designed to explore the possibility that sulfated polysaccharides had the potential to prevent human leukocyte elastase (HLE)-induced lung injury.	Polysaccharides	63-78	elastase, neutrophil expressed	Homo sapiens	134-137
1974403-5	1990	The results suggest that sulfated polysaccharides may be potent inhibitors of HLE-mediated lung injury.	Polysaccharides	34-49	elastase, neutrophil expressed	Homo sapiens	78-81
2390069-0	1990	Primary structure of glycans isolated from human leucocyte lactotransferrin.	Polysaccharides	21-28	lactotransferrin	Homo sapiens	59-75
2385230-6	1990	The labeled A2AR demonstrates a sensitivity to neuraminidase, as evidenced by an increased mobility on gel electrophoresis, suggesting the receptors contain a glycan component containing terminal sialic acid.	Polysaccharides	159-165	adenosine A2a receptor	Homo sapiens	12-16
2390069-3	1990	A comparative analysis of the molar carbohydrate compositions of human leucocyte lactotransferrin and human milk lactotransferrin reveals that the glycans of leucocyte lactotransferrin differ essentially by the absence of fucose residues.	Polysaccharides	147-154	lactotransferrin	Homo sapiens	113-129
2390069-3	1990	A comparative analysis of the molar carbohydrate compositions of human leucocyte lactotransferrin and human milk lactotransferrin reveals that the glycans of leucocyte lactotransferrin differ essentially by the absence of fucose residues.	Polysaccharides	147-154	lactotransferrin	Homo sapiens	113-129
2390069-5	1990	spectrometry of oligosaccharide alditols released from human leucocyte lactotransferrin shows the presence of two disialylated and non-fucosylated biantennary glycans of the N-acetyl-lactosaminic type.	Polysaccharides	159-166	lactotransferrin	Homo sapiens	71-87
2126464-4	1990	The biological activity of antithrombin III is mediated by a polysaccharide, heparin.	Polysaccharides	61-75	serpin family C member 1	Homo sapiens	27-43
2385230-6	1990	The labeled A2AR demonstrates a sensitivity to neuraminidase, as evidenced by an increased mobility on gel electrophoresis, suggesting the receptors contain a glycan component containing terminal sialic acid.	Polysaccharides	159-165	neuraminidase 1	Homo sapiens	47-60
2104493-1	1990	The in vivo effects of Phytolacca acinosa polysaccharides I (PEP-I) on immunologic cytotoxicity of mouse peritoneal macrophages and its production of tumor necrosis factor (TNF) and interleukin 1 (IL-1) were studied.	Polysaccharides	42-57	tumor necrosis factor	Mus musculus	150-171
2236295-7	1990	When F-5, which has the most potent of both activities, was further fractionated, only the major acidic polysaccharide fraction, F-5-2, showed potent mitogenic activity.	Polysaccharides	104-118	coagulation factor V	Homo sapiens	129-132
2236295-5	1990	Methylation analysis indicated that F-2 mainly contained amylopectin-like polysaccharides.	Polysaccharides	74-89	coagulation factor II, thrombin	Homo sapiens	36-39
2236295-7	1990	When F-5, which has the most potent of both activities, was further fractionated, only the major acidic polysaccharide fraction, F-5-2, showed potent mitogenic activity.	Polysaccharides	104-118	coagulation factor V	Homo sapiens	5-8
2163607-5	1990	Heparin, a sulphated polysaccharide which binds to Ins(1,4,5)P3 receptors in several tissues, inhibited both the binding of radiolabelled Ins(1,4,5)P3 and its Ca2(+)-releasing activity in adrenal microsomes.	Polysaccharides	21-35	carbonic anhydrase 2	Bos taurus	159-162
2208191-0	1990	A regio- and stereo-controlled synthesis of beta-D-Glcp NAc6SO3-(1----3)-beta-D-Galp6SO3-(1----4)-beta-D-GlcpNAc 6SO3- (1----3)-D-Galp, a linear acidic glycan fragment of keratan sulfate I.	Polysaccharides	152-158	galanin like peptide	Homo sapiens	80-84
2165887-2	1990	Using crossed immunoaffinity electrophoresis with free concanavalin A in the first dimension, we studied the glycan microheterogeneity of alpha 1-antichymotrypsin in sera from patients with giant-cell arteritis and/or polymyalgia rheumatica, and its variation in the serum of several of these patients during induction of disease remission by prednisone therapy and possible further recurrence of giant-cell arteritis and/or polymyalgia rheumatica.	Polysaccharides	109-115	serpin family A member 3	Homo sapiens	138-162
1699884-1	1990	This study has analysed the binding of a series of anti-CD2 monoclonal antibodies (MoAbs) to T cells in the presence of the sulfated polysaccharide dextran sulfate (2.3 sulfates/monosaccharide, 500 kDa) (DXS) to define the DXS binding site on CD2.	Polysaccharides	133-147	T-cell surface antigen CD2	Ovis aries	56-59
2085476-0	1990	[Tumor-regressing factor induced by antitumor polysaccharide in the serum of tumor-bearing mice].	Polysaccharides	46-60	interleukin 5	Mus musculus	1-24
1693564-1	1990	We studied the oligosaccharide moieties of recombinant human thyroid peroxidase (hTPO) expressed in Chinese hamster ovary (CHO) cells, and the role of these glycans in hTPO antigenicity in Hashimoto"s thyroiditis.	Polysaccharides	157-164	thyroid peroxidase	Homo sapiens	168-172
1693564-10	1990	In summary, the present data indicate that: i) hTPO expressed in CHO cells contains N-linked, but not O-linked glycan moieties; ii) the N-linked carbohydrate is primarily of the polymannose variety; and, iii) the glycan moieties do not contribute to the hTPO epitopes in Hashimoto"s thyroiditis.	Polysaccharides	111-117	thyroid peroxidase	Homo sapiens	47-51
2187813-1	1990	A family of immunoglobulin isotype-switch variants was isolated by sib selection from a murine hybridoma which produced an immunoglobulin G subclass 1 (IgG1) antibody specific for the capsular polysaccharide of Cryptococcus neoformans.	Polysaccharides	193-207	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	123-150
2187813-1	1990	A family of immunoglobulin isotype-switch variants was isolated by sib selection from a murine hybridoma which produced an immunoglobulin G subclass 1 (IgG1) antibody specific for the capsular polysaccharide of Cryptococcus neoformans.	Polysaccharides	193-207	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	152-156
2187813-2	1990	Antibodies of the IgG1, IgG2a, and IgG2b isotypes had similar serotype specificity patterns in double immunodiffusion assays which used polysaccharides of the four cryptococcal serotypes as antigens.	Polysaccharides	136-151	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	18-22
2369086-1	1990	A protein-bound polysaccharide, PSK, extracted from the mycelium of Coriolus versicolor (Fr.)	Polysaccharides	16-30	TAO kinase 2	Homo sapiens	32-35
2187813-2	1990	Antibodies of the IgG1, IgG2a, and IgG2b isotypes had similar serotype specificity patterns in double immunodiffusion assays which used polysaccharides of the four cryptococcal serotypes as antigens.	Polysaccharides	136-151	immunoglobulin heavy constant gamma 2B	Mus musculus	35-40
1695800-8	1990	The results indicate that the epitopes of SPC-A-1 cell extract reacted with McAb LC-1 are probably located in the polysaccharide.	Polysaccharides	114-128	proline rich protein gene cluster	Homo sapiens	42-45
1976012-0	1990	Regulation of mouse T cell associated serine proteinase-1 (MTSP-1) by proteinase inhibitors and sulfated polysaccharides.	Polysaccharides	105-120	suppression of tumorigenicity 14 (colon carcinoma)	Mus musculus	59-65
2137773-9	1990	With dMM, complex-type glycans of Tg were totally replaced by high mannose-type glycans, Man8-9GlcNAc; Cs induced the accumulation of glucosylated high mannose-type structures, Glc3Man7-9GlcNAc and Glc2Man8-9GlcNAc, but the action of this inhibitor was not total.	Polysaccharides	23-30	thyroglobulin	Homo sapiens	34-36
2321963-0	1990	Glycan research on barley, maize, oats, and sorghum grain alpha-amylases: comparison with rice alpha-amylase.	Polysaccharides	0-6	alpha-amylase	Zea mays	58-71
2140287-0	1990	Binding of staphylococcal cell surface polysaccharide to human fibrinogen.	Polysaccharides	39-53	fibrinogen beta chain	Homo sapiens	63-73
2140287-1	1990	The interaction between the binding site of a polysaccharide (called compact colony forming active substance (CCFAS)), obtained from the cell surface of a strain of Staphylococcus, and human fibrinogen (HF) was investigated.	Polysaccharides	46-60	fibrinogen beta chain	Homo sapiens	191-201
2158279-4	1990	The oligosaccharide chains of the glycoprotein can be released by treatment with endoglycosidase H, suggesting that gp46 has high-mannose type of glycans.	Polysaccharides	146-153	serpin family H member 1	Rattus norvegicus	116-120
1692629-2	1990	It has been recently demonstrated that attachment of complement component C3b to activator-derived molecules (e.g., small polysaccharides) restricts inactivation of C3b by factors H and I in a manner similar to activator surfaces.	Polysaccharides	122-137	endogenous retrovirus group K member 3	Homo sapiens	74-77
1692629-2	1990	It has been recently demonstrated that attachment of complement component C3b to activator-derived molecules (e.g., small polysaccharides) restricts inactivation of C3b by factors H and I in a manner similar to activator surfaces.	Polysaccharides	122-137	endogenous retrovirus group K member 3	Homo sapiens	165-168
2338081-8	1990	Our results are consistent both with the existence of several specific enzymes for alpha 1-2, alpha 1-3 and alpha 1-6 linkages, and with the presence of a unique enzyme whose specificity would be dependent either on Zn2+ or on the spatial conformation of the glycan.	Polysaccharides	259-265	adrenoceptor alpha 1D	Homo sapiens	83-117
1367433-6	1990	We found that with one exception, all mutant activators lack the high mannose glycan found at asn 117 of native t-PA.	Polysaccharides	78-84	plasminogen activator, tissue	Mus musculus	112-116
2161375-7	1990	The treatment with periodic acid, neraminidase, trypsin and pronase revealed that antigenic epitopes of Pak-1 and Pak-2 may be composed of complex polysaccharide structure rather than terminal sialic acid residues.	Polysaccharides	147-161	p21 (RAC1) activated kinase 1	Homo sapiens	104-109
2161375-7	1990	The treatment with periodic acid, neraminidase, trypsin and pronase revealed that antigenic epitopes of Pak-1 and Pak-2 may be composed of complex polysaccharide structure rather than terminal sialic acid residues.	Polysaccharides	147-161	p21 (RAC1) activated kinase 2	Homo sapiens	114-119
2139103-5	1990	However, Fc gamma RIII on neutrophils, a molecule linked to the membrane by a phosphatidylinositol-glycan moiety, although binding anti-Fc gamma RIII-coated erythrocytes vigorously was incapable of mounting a phagocytic response.	Polysaccharides	99-105	Fc gamma receptor IIIa	Homo sapiens	9-22
2139103-5	1990	However, Fc gamma RIII on neutrophils, a molecule linked to the membrane by a phosphatidylinositol-glycan moiety, although binding anti-Fc gamma RIII-coated erythrocytes vigorously was incapable of mounting a phagocytic response.	Polysaccharides	99-105	Fc gamma receptor IIIa	Homo sapiens	136-149
1966997-1	1990	We investigated the effect of PSK, a protein-bound polysaccharide obtained from the basidiomycetes Coriolus versicolor, on an immunosuppressive factor produced in tumor-bearing animals.	Polysaccharides	51-65	TAO kinase 2	Mus musculus	30-33
2155025-11	1990	These data provide definitive evidence that IAP is anchored by PI-glycan and conclusively demonstrate that the unique COOH-terminal structure encoded by this rat mRNA supports the addition of a PI-glycan anchor.	Polysaccharides	66-72	alkaline phosphatase, intestinal	Homo sapiens	44-47
2193068-8	1990	4) It was observed that polysaccharide "M9" liked to combine with protein "R" and without other proteins, as our collection extends.	Polysaccharides	24-38	eukaryotic translation initiation factor 3 subunit K	Homo sapiens	40-43
2105993-0	1990	Human polysaccharide-specific B cells are responsive to pokeweed mitogen and IL-6.	Polysaccharides	6-20	interleukin 6	Homo sapiens	77-81
2105993-11	1990	Finally, anti-IL-6 antibody blocked PWM-induced total and polysaccharide-specific antibody production.	Polysaccharides	58-72	interleukin 6	Homo sapiens	14-18
2105993-12	1990	We conclude that human polysaccharide-specific B cells are responsive to PWM and IL-6.	Polysaccharides	23-37	interleukin 6	Homo sapiens	81-85
12106058-6	1990	These observations, together with previous studies on the L2/HNK-1 glycan (Kunemund et al., 1988), indicate that adhesion molecules carry various carbohydrate epitopes mediating different cell interactions in in vitro assays.	Polysaccharides	67-73	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	61-66
1967276-1	1990	A novel class of cell surface proteins are attached to the plasma membrane via a phosphatidylinositol (PI)-glycan anchoring structure, and these proteins can be selectively removed from the cell surface by the enzyme PI-specific phospholipase C (PI-PLC).	Polysaccharides	107-113	protein disulfide isomerase associated 3	Mus musculus	217-244
1967276-1	1990	A novel class of cell surface proteins are attached to the plasma membrane via a phosphatidylinositol (PI)-glycan anchoring structure, and these proteins can be selectively removed from the cell surface by the enzyme PI-specific phospholipase C (PI-PLC).	Polysaccharides	107-113	protein disulfide isomerase associated 3	Mus musculus	246-252
1967276-4	1990	This decrease in PI-PLC sensitivity may reflect an alteration in the PI-glycan anchoring structures, or in a general membrane property, which renders the PI-anchored proteins inaccessible to the enzyme.	Polysaccharides	72-78	protein disulfide isomerase associated 3	Mus musculus	17-23
2110432-1	1990	PSK, a protein-bound polysaccharide extracted from the mycelia of Coriolus versicolor (Fr.)	Polysaccharides	21-35	TAO kinase 2	Homo sapiens	0-3
2405068-5	1990	These results indicate that the anti-HIV activity of sulfated polysaccharides can be dissociated from their antithrombin activity.	Polysaccharides	62-77	serpin family C member 1	Homo sapiens	108-120
2183563-4	1990	Supernatants from normal spleen cells treated in vitro either with the polysaccharide or the intact endotoxin showed immunoenhancing helper activity for both normal and FLV infected spleen cells and this enhancing activity was due to IL-1 induced by either bacterial product.	Polysaccharides	71-85	interleukin 1 complex	Mus musculus	234-238
2405068-0	1990	Novel sulfated polysaccharides: dissociation of anti-human immunodeficiency virus activity from antithrombin activity.	Polysaccharides	15-30	serpin family C member 1	Homo sapiens	96-108
2198088-1	1990	To examine the clinical efficacy and the mechanism of action of polysaccharide K (PSK), a protein-bound polysaccharide extracted from a Basidiomycetes fungus, a randomized double-blind trial was performed by administering PSK to 56 patients and a placebo to another group of 55 patients after surgical operations on their colorectal cancers.	Polysaccharides	64-78	TAO kinase 2	Homo sapiens	82-85
2322419-4	1990	Thus, the slow reactions in the case of bovine and pig HA-heparins were probably due to preferential binding of the two HA-heparins to thrombin rather than to ATIII, thus causing the HA-heparins to be inhibitory for the reaction by reducing the turnover rates of the polysaccharides as catalysts.	Polysaccharides	267-282	coagulation factor II, thrombin	Sus scrofa	135-143
1696539-5	1990	Using this flow cytometric method we have demonstrated that those compounds (i.e., sulfated polysaccharides, aurintricarboxylic acid) that interact with gp120 (of the HIV-infected cells) or CD4 (of the uninfected cells) suppress syncytium formation and concomitant destruction of the CD4+ cells.	Polysaccharides	92-107	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	153-158
1696539-5	1990	Using this flow cytometric method we have demonstrated that those compounds (i.e., sulfated polysaccharides, aurintricarboxylic acid) that interact with gp120 (of the HIV-infected cells) or CD4 (of the uninfected cells) suppress syncytium formation and concomitant destruction of the CD4+ cells.	Polysaccharides	92-107	CD4 molecule	Homo sapiens	190-193
1696539-5	1990	Using this flow cytometric method we have demonstrated that those compounds (i.e., sulfated polysaccharides, aurintricarboxylic acid) that interact with gp120 (of the HIV-infected cells) or CD4 (of the uninfected cells) suppress syncytium formation and concomitant destruction of the CD4+ cells.	Polysaccharides	92-107	CD4 molecule	Homo sapiens	284-287
33941700-4	2021	Constructs with 2 to 6 Gal3 subunits ("Dimer," "Trimer," "Tetramer," "Pentamer," "Hexamer") demonstrated glycan-binding properties and cell death-inducing potency that scaled with valency.	Polysaccharides	105-111	galectin 3	Homo sapiens	23-27
1689664-5	1990	Comparison of the CD59 protein sequence with those of the Ly-6E and Ly-6C antigens discloses a similarity in overall structure, including the alignment of abundant cysteine residues, hydrophobic carboxy termini and conservation of amino acids surrounding the proposed phosphatidylinositol-glycan modification site for Ly-6 molecules.	Polysaccharides	289-295	CD59a antigen	Mus musculus	18-22
2129420-3	1990	Individuals were immunized with polysaccharides isolated from LPS of Pseudomonas aeruginosa conjugated to toxin A.	Polysaccharides	32-47	toll-like receptor 4	Mus musculus	62-65
2090874-1	1990	The protein-bound polysaccharide extracted from a fungus, PSK, has been used as a biological response modifier in the treatment of cancer patients in Japan for over ten years.	Polysaccharides	18-32	TAO kinase 2	Homo sapiens	58-61
2176268-0	1990	Gastroenteritis in suckling mice caused by human rotavirus can be prevented with egg yolk immunoglobulin (IgY) and treated with a protein-bound polysaccharide preparation (PSK).	Polysaccharides	144-158	TAO kinase 2	Mus musculus	172-175
2176268-6	1990	The four different strains of human rotavirus (Wa, KUN, MO, and ST3) were inactivated in vitro by treatment with PSK, a protein-bound polysaccharide preparation, in a dose-dependent manner.	Polysaccharides	134-148	matrix metallopeptidase 11	Mus musculus	64-67
2176268-6	1990	The four different strains of human rotavirus (Wa, KUN, MO, and ST3) were inactivated in vitro by treatment with PSK, a protein-bound polysaccharide preparation, in a dose-dependent manner.	Polysaccharides	134-148	TAO kinase 2	Mus musculus	113-116
2153284-0	1990	Selectivity of the cleavage/attachment site of phosphatidylinositol-glycan-anchored membrane proteins determined by site-specific mutagenesis at Asp-484 of placental alkaline phosphatase.	Polysaccharides	68-74	alkaline phosphatase, placental	Homo sapiens	156-186
33765222-5	2021	The improved chromatographic separation allowed the identification of six single glycan traits and a derived antennary fucosylation trait that were able to differentiate individuals carrying pathogenic mutations from benign or no HNF1A mutation cases, as determined by the area under the curve (AUC) of up to 0.94.	Polysaccharides	81-87	HNF1 homeobox A	Homo sapiens	230-235
33765222-6	2021	The excellent (r = 0.88) interlaboratory performance of the glycan biomarker for HNF1A-MODY further supports the development of a clinically relevant diagnostic test measuring antennary fucosylation levels.	Polysaccharides	60-66	HNF1 homeobox A	Homo sapiens	81-86
33232564-10	2021	The main genes identified for RFT were GSK3beta, LRP1B, EXT1, GRB2, SORCS1 and SLMAP, which are involved in metabolic pathways such as glycogen synthesis, lipid transport and homeostasis, polysaccharide and carbohydrate metabolism.	Polysaccharides	188-202	glycogen synthase kinase 3 alpha	Bos taurus	39-47
33232564-10	2021	The main genes identified for RFT were GSK3beta, LRP1B, EXT1, GRB2, SORCS1 and SLMAP, which are involved in metabolic pathways such as glycogen synthesis, lipid transport and homeostasis, polysaccharide and carbohydrate metabolism.	Polysaccharides	188-202	low-density lipoprotein receptor-related protein 1B	Bos taurus	49-54
33232564-10	2021	The main genes identified for RFT were GSK3beta, LRP1B, EXT1, GRB2, SORCS1 and SLMAP, which are involved in metabolic pathways such as glycogen synthesis, lipid transport and homeostasis, polysaccharide and carbohydrate metabolism.	Polysaccharides	188-202	exostosin glycosyltransferase 1	Bos taurus	56-60
33232564-10	2021	The main genes identified for RFT were GSK3beta, LRP1B, EXT1, GRB2, SORCS1 and SLMAP, which are involved in metabolic pathways such as glycogen synthesis, lipid transport and homeostasis, polysaccharide and carbohydrate metabolism.	Polysaccharides	188-202	growth factor receptor bound protein 2	Bos taurus	62-66
33232564-10	2021	The main genes identified for RFT were GSK3beta, LRP1B, EXT1, GRB2, SORCS1 and SLMAP, which are involved in metabolic pathways such as glycogen synthesis, lipid transport and homeostasis, polysaccharide and carbohydrate metabolism.	Polysaccharides	188-202	sortilin related VPS10 domain containing receptor 1	Bos taurus	68-74
33232564-10	2021	The main genes identified for RFT were GSK3beta, LRP1B, EXT1, GRB2, SORCS1 and SLMAP, which are involved in metabolic pathways such as glycogen synthesis, lipid transport and homeostasis, polysaccharide and carbohydrate metabolism.	Polysaccharides	188-202	sarcolemma associated protein	Bos taurus	79-84
1691288-4	1990	Pentosan polysulfate, dextran sulfate, and various other sulfated polysaccharides, but not heparin, have proved to inhibit this cell fusion process and hence protect the target CD4+ cells against destruction by the killer HIV-1-infected cells.	Polysaccharides	66-81	CD4 molecule	Homo sapiens	177-180
2295683-7	1990	Aggregation or adhesion between L1- and N-CAM-positive neuroblastoma N2A cells was reduced when the synthesis of complex and/or hybrid glycans was modified by castanospermine.	Polysaccharides	135-142	neural cell adhesion molecule 1	Mus musculus	40-45
33971197-4	2021	GAA undergoes both proteolytic cleavage and glycan trimming within the endolysosomal pathway, yielding an enzyme that is more efficient in hydrolyzing its natural substrate, glycogen.	Polysaccharides	44-50	alpha glucosidase	Homo sapiens	0-3
33817815-0	2021	Preparation and characterization of metal-tea polysaccharide complexes and their inhibition on alpha-glucosidase.	Polysaccharides	46-60	sucrase-isomaltase	Homo sapiens	95-112
33822948-5	2021	Based on this finding, we assessed whether the application of human LYPD8 (hLYPD8) protein exhibiting the glycan-dependent inhibition of bacterial motility is effective in a colitis model.	Polysaccharides	106-112	LY6/PLAUR domain containing 8	Homo sapiens	68-73
33822948-5	2021	Based on this finding, we assessed whether the application of human LYPD8 (hLYPD8) protein exhibiting the glycan-dependent inhibition of bacterial motility is effective in a colitis model.	Polysaccharides	106-112	LY6/PLAUR domain containing 8	Homo sapiens	75-81
33805009-12	2021	The results obtained indicate that the polysaccharides from P. cruentum are potent inducers of IL-6 cytokines and, most importantly, of TNF-alpha.	Polysaccharides	39-54	tumor necrosis factor	Mus musculus	136-145
33812257-0	2021	Structural characterization and amelioration of sulfated polysaccharides from Ganoderma applanatum residue against CCl4-induced hepatotoxicity.	Polysaccharides	57-72	chemokine (C-C motif) ligand 4	Mus musculus	115-119
33806781-5	2021	Polysaccharide content was selected according to foaming, organoleptic antioxidant and angiotensin-I-converting enzyme inhibitory characteristics of the resulted composition.	Polysaccharides	0-14	angiotensin I converting enzyme	Rattus norvegicus	87-118
33804076-3	2021	It has been suggested that full-length (FL)-Gal-9 and the truncated (Tr)-Gal-9s could exert different functions from one another via their different glycan-binding activities.	Polysaccharides	149-155	galectin 9	Homo sapiens	44-49
33804076-3	2021	It has been suggested that full-length (FL)-Gal-9 and the truncated (Tr)-Gal-9s could exert different functions from one another via their different glycan-binding activities.	Polysaccharides	149-155	galectin 9	Homo sapiens	73-78
33767710-2	2021	A human C-type lectin protein CLEC18A in particular shows extensive glycan binding abilities and correlates with type-I interferon expression, making CLEC18A a potential player in innate immune responses to DENV infection; this potential may provide additional regulatory point in improving mosquito immunity.	Polysaccharides	68-74	C-type lectin domain family 18 member A	Homo sapiens	30-37
33589564-6	2021	Herein we found that release of sperm from an immobilized oviduct glycan, a 6-sialylated branched structure, and from immobilized fibronectin was inhibited by the CatSper blocker NNC 055-0396, akin to the previously reported ability of NNC 055-0396 to inhibit sperm release from another oviduct glycan, sulfated Lewis X trisaccharide.	Polysaccharides	66-72	cation channel sperm associated 1	Homo sapiens	163-170
33589564-6	2021	Herein we found that release of sperm from an immobilized oviduct glycan, a 6-sialylated branched structure, and from immobilized fibronectin was inhibited by the CatSper blocker NNC 055-0396, akin to the previously reported ability of NNC 055-0396 to inhibit sperm release from another oviduct glycan, sulfated Lewis X trisaccharide.	Polysaccharides	295-301	fibronectin 1	Homo sapiens	130-141
33589564-6	2021	Herein we found that release of sperm from an immobilized oviduct glycan, a 6-sialylated branched structure, and from immobilized fibronectin was inhibited by the CatSper blocker NNC 055-0396, akin to the previously reported ability of NNC 055-0396 to inhibit sperm release from another oviduct glycan, sulfated Lewis X trisaccharide.	Polysaccharides	295-301	cation channel sperm associated 1	Homo sapiens	163-170
33806943-3	2021	Lectin-glycan interaction effects on settlement and its localization on oyster larval tissues were investigated.	Polysaccharides	7-13	C-type lectin BfL-2	Crassostrea gigas	0-6
33815739-5	2021	Additionally, the structure of DS-epi1 reveals a high structural similarity to proteins from several families of bacterial polysaccharide lyases.	Polysaccharides	123-137	dermatan sulfate epimerase	Homo sapiens	31-38
33802031-11	2021	Results showed that mechanochemically obtained complexes with polysaccharide AG, Na2GA, and HP-beta-CD enhanced permeation of NIM across an artificial membrane compared to that of the pure NIM.	Polysaccharides	62-76	adrenocortical dysplasia	Mus musculus	95-102
33804445-5	2021	To date, chitosan (CS) is among the most common materials in the formulation of these biodegradable packaging together with polysaccharides, proteins, and lipids.	Polysaccharides	124-139	citrate synthase	Homo sapiens	19-21
32890705-0	2020	Recognition of glycan and protein substrates by N-acetylglucosaminyltransferase-V.	Polysaccharides	15-21	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	48-81
33031880-0	2021	Biocompatible sulfated valproic acid-coupled polysaccharide-based nanocarriers with HDAC inhibitory activity.	Polysaccharides	45-59	histone deacetylase 9	Homo sapiens	84-88
33232457-1	2020	Alpha-1,3-glucan, in addition to beta-1,3-glucan, is an important polysaccharide component of fungal cell walls.	Polysaccharides	66-80	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	0-9
34563529-5	2022	H16 to promote plant growth, but stimulated the production of extracellular polysaccharides and inorganic labile sulfide, and enhanced biofilm formation, thereby significantly improved the removal efficiency of Cu2+, Zn2+, Cd2+, and Pb2+.	Polysaccharides	76-91	H1.6 linker histone, cluster member	Homo sapiens	0-3
33236007-4	2020	We present several novel scientific discoveries, including the elucidation of the spike"s full glycan shield, the role of spike glycans in modulating the infectivity of the virus, and the characterization of the flexible interactions between the spike and the human ACE2 receptor.	Polysaccharides	95-101	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	82-87
32797816-0	2020	Advancing stereoisomeric separation of an atropisomeric Bruton"s tyrosine kinase inhibitor by using sub-2 microm immobilized polysaccharide-based chiral columns in supercritical fluid chromatography.	Polysaccharides	125-139	Bruton tyrosine kinase	Homo sapiens	56-80
33817185-1	2019	Aim: This study investigates the effect of astragalus polysaccharides (APS) in protecting against thapsigargin-induced endoplasmic reticulum (ER) stress in HT29 cells by suppressing the PERK-eIF2a signaling pathway.	Polysaccharides	54-69	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	186-190
33817185-1	2019	Aim: This study investigates the effect of astragalus polysaccharides (APS) in protecting against thapsigargin-induced endoplasmic reticulum (ER) stress in HT29 cells by suppressing the PERK-eIF2a signaling pathway.	Polysaccharides	54-69	eukaryotic translation initiation factor 2 subunit alpha	Homo sapiens	191-196
26377892-3	2015	(2015) show that TREX1 also safeguards the cell against free glycan build-up in the endoplasmic reticulum, thereby preventing glycan-induced inflammation.	Polysaccharides	61-67	three prime repair exonuclease 1	Homo sapiens	17-22
26377892-3	2015	(2015) show that TREX1 also safeguards the cell against free glycan build-up in the endoplasmic reticulum, thereby preventing glycan-induced inflammation.	Polysaccharides	126-132	three prime repair exonuclease 1	Homo sapiens	17-22
26388028-3	2015	Thus, crystal structures of heavily glycosylated proteins such as the HIV-1 Env viral spike protein have been determined by removing the majority of glycans.	Polysaccharides	149-156	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	76-79
22575017-5	2012	Flow cytometry and agglutination assays show that 0118 attenuates binding of galectin-1 to cell surface glycans, and the inhibition of cell proliferation by 0118 is found to be correlated with the cellular expression of the lectin.	Polysaccharides	104-111	galectin 1	Homo sapiens	77-87
22575017-6	2012	In general, our data indicate that 0118 targets galectin-1 as an allosteric inhibitor of glycan/carbohydrate binding.	Polysaccharides	89-95	galectin 1	Homo sapiens	48-58
19433864-4	2009	Proteomic and glycomic analysis of these glycoproteins by mass spectrometry showed that they are forms of CD98hc that bear glycans displaying heavily fucosylated termini, including Lewis(x) and Lewis(y) structures.	Polysaccharides	123-130	solute carrier family 3 member 2	Homo sapiens	106-110
19451548-0	2009	Quality control of glycoproteins bearing truncated glycans in an ALG9-defective (CDG-IL) patient.	Polysaccharides	51-58	ALG9 alpha-1,2-mannosyltransferase	Homo sapiens	65-69
34563529-7	2022	The C-OH and PO groups related to polysaccharides play a crucial role in heavy metal adsorption, and the immobilization mechanism of the planktonic cell is mainly ion exchange and group complex, but for H16, intracellular enrichment cannot be ignored.	Polysaccharides	34-49	H1.6 linker histone, cluster member	Homo sapiens	203-206
32796613-1	2020	Our group and others have previously shown that genistein combined polysaccharide (GCP), an aglycone isoflavone-rich extract with high bioavailability and low toxicity, can inhibit prostate cancer (CaP) cell growth and survival as well as androgen receptor (AR) activity.	Polysaccharides	67-81	androgen receptor	Homo sapiens	239-256
32796613-1	2020	Our group and others have previously shown that genistein combined polysaccharide (GCP), an aglycone isoflavone-rich extract with high bioavailability and low toxicity, can inhibit prostate cancer (CaP) cell growth and survival as well as androgen receptor (AR) activity.	Polysaccharides	67-81	androgen receptor	Homo sapiens	258-260
26320659-5	2015	C-terminal truncation of TREX1 by fs mutations dysregulated the OST complex, leading to free glycan release from dolichol carriers, as well as immune activation and autoantibody production.	Polysaccharides	93-99	three prime repair exonuclease 1	Mus musculus	25-30
21178016-5	2011	We also find that glycan ligand-based cargo is released from CD22 and accumulates intracellularly as CD22 recycles between the cell surface and endosomal compartments.	Polysaccharides	18-24	CD22 molecule	Homo sapiens	61-65
21178016-5	2011	We also find that glycan ligand-based cargo is released from CD22 and accumulates intracellularly as CD22 recycles between the cell surface and endosomal compartments.	Polysaccharides	18-24	CD22 molecule	Homo sapiens	101-105
34839969-0	2022	Interaction between polysaccharides and toll-like receptor 4: Primary structural role, immune balance perspective, and 3D interaction model hypothesis.	Polysaccharides	20-35	toll like receptor 4	Homo sapiens	40-60
34839969-1	2022	Various structural types of polysaccharides are recognized by toll-like receptor 4 (TLR4).	Polysaccharides	28-43	toll like receptor 4	Homo sapiens	62-82
34839969-1	2022	Various structural types of polysaccharides are recognized by toll-like receptor 4 (TLR4).	Polysaccharides	28-43	toll like receptor 4	Homo sapiens	84-88
34839969-2	2022	However, the mechanism of interaction between the polysaccharides with different structures and TLR4 is unclarified.	Polysaccharides	50-65	toll like receptor 4	Homo sapiens	96-100
34839969-3	2022	This review summarized the primary structure of polysaccharides related to TLR4, mainly including molecular weight, monosaccharide composition, glycosidic bonds, functional groups, and branched-chain structure.	Polysaccharides	48-63	toll like receptor 4	Homo sapiens	75-79
34839969-5	2022	Besides, the dual-directional regulation of TLR4 signaling cascade by polysaccharides was also elucidated from an immune balance perspective.	Polysaccharides	70-85	toll like receptor 4	Homo sapiens	44-48
34839969-6	2022	Finally, the 3D interaction model of polysaccharides to TLR4-myeloid differentiation factor 2 (MD2) complex was hypothesized according to the LPS-TLR4-MD2 dimerization model and the polysaccharides solution conformation.	Polysaccharides	37-52	lymphocyte antigen 96	Homo sapiens	56-93
34839969-6	2022	Finally, the 3D interaction model of polysaccharides to TLR4-myeloid differentiation factor 2 (MD2) complex was hypothesized according to the LPS-TLR4-MD2 dimerization model and the polysaccharides solution conformation.	Polysaccharides	37-52	lymphocyte antigen 96	Homo sapiens	95-98
34839969-6	2022	Finally, the 3D interaction model of polysaccharides to TLR4-myeloid differentiation factor 2 (MD2) complex was hypothesized according to the LPS-TLR4-MD2 dimerization model and the polysaccharides solution conformation.	Polysaccharides	37-52	toll like receptor 4	Homo sapiens	146-150
34839969-6	2022	Finally, the 3D interaction model of polysaccharides to TLR4-myeloid differentiation factor 2 (MD2) complex was hypothesized according to the LPS-TLR4-MD2 dimerization model and the polysaccharides solution conformation.	Polysaccharides	37-52	lymphocyte antigen 96	Homo sapiens	151-154
34839969-6	2022	Finally, the 3D interaction model of polysaccharides to TLR4-myeloid differentiation factor 2 (MD2) complex was hypothesized according to the LPS-TLR4-MD2 dimerization model and the polysaccharides solution conformation.	Polysaccharides	182-197	lymphocyte antigen 96	Homo sapiens	56-93
34839969-6	2022	Finally, the 3D interaction model of polysaccharides to TLR4-myeloid differentiation factor 2 (MD2) complex was hypothesized according to the LPS-TLR4-MD2 dimerization model and the polysaccharides solution conformation.	Polysaccharides	182-197	lymphocyte antigen 96	Homo sapiens	95-98
34839969-7	2022	The essence of polysaccharides binding to TLR4-MD2 complex is a multivalent non-covalent bond interaction.	Polysaccharides	15-30	toll like receptor 4	Homo sapiens	42-46
34839969-7	2022	The essence of polysaccharides binding to TLR4-MD2 complex is a multivalent non-covalent bond interaction.	Polysaccharides	15-30	lymphocyte antigen 96	Homo sapiens	47-50
34839969-8	2022	All the arguments summarized in this review are intended to provide some new insights into the interaction between polysaccharides and TLR4.	Polysaccharides	115-130	toll like receptor 4	Homo sapiens	135-139
34875432-1	2022	To optimize the extraction of polysaccharides from coix seeds (CSP), an auxiliary method of ultrasound was developed by response surface methodology (RSM).	Polysaccharides	30-45	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	63-66
34875432-4	2022	FT-IR indicated that CSP extracted by UE and HE were neutral polysaccharides, and linkages between sugar units were mainly in the alpha-conformation.	Polysaccharides	61-76	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	21-24
34875432-5	2022	Furthermore, NMR spectra indicated that UE-treated CSP was a neutral polysaccharide with (1   6)-linked alpha-d-glucopyranose in the main chain.	Polysaccharides	69-83	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	51-54
34875432-6	2022	Two polysaccharide components (CSP-A and CSP-B) were purified by anion exchange chromatography, therein, CSP-A was more resistant to the digestion in stomach and intestine.	Polysaccharides	4-18	granzyme B	Homo sapiens	41-46
34775642-11	2022	Thus, SKS11/12 are required for pollen tube integrity, growth, and guidance possibly by regulating the ROS level and cell wall polysaccharide deposition or remodeling in pollen tubes.	Polysaccharides	127-141	SKU5 similar 11	Arabidopsis thaliana	6-14
34968535-3	2022	In vivo experiments showed that the crude polysaccharide of A. zhejiangensis (AZP) exhibited significant hepatoprotective effects, decreasing the serum levels of ALT, AST and LDH in CCl4-treated mice, reducing MDA content, promoting SOD and CAT activities, and increasing GSH level in liver.	Polysaccharides	42-56	catalase	Mus musculus	241-244
34973762-0	2022	A hexasaccharide from capsular polysaccharide of carbapenem-resistant Klebsiella pneumoniae KN2 is a ligand of Toll-like receptor 4.	Polysaccharides	31-45	toll like receptor 4	Homo sapiens	111-131
34965721-1	2022	A new mass spectrometry method, logically derived sequence (LODES) tandem mass spectrometry (MSn), was applied to determine the primary structure of polysaccharide lichenin.	Polysaccharides	149-163	moesin	Homo sapiens	93-96
34965721-4	2022	In this new method, polysaccharides are hydrolyzed into monosaccharides, disaccharides, and oligosaccharides, and structures of these molecules are determined using LODES/MSn.	Polysaccharides	20-35	moesin	Homo sapiens	171-174
34965721-5	2022	The application of LODES/MSn for determination of primary structure of polysaccharide lichenin was demonstrated.	Polysaccharides	71-85	moesin	Homo sapiens	25-28
34965721-7	2022	LODES/MSn, which substantially reduces the time, effort, and sample quantity necessary for structural determination of oligosaccharides, is a powerful tool for polysaccharide primary structural determination.	Polysaccharides	160-174	moesin	Homo sapiens	6-9
34964144-0	2022	Modulation of Notch signaling and angiogenesis via an isolated polysaccharide from Momordica charantia in diabetic rats.	Polysaccharides	63-77	notch receptor 1	Rattus norvegicus	14-19
34964144-1	2022	Given the impact of notch signaling in the modulation of metabolic diseases and normal tissue homeostasis, this study aimed to evaluate whether notch signaling has a role in anti-diabetic and islet regenerative effects of the isolated polysaccharide from Momordica charantia in diabetic rats.	Polysaccharides	235-249	notch receptor 1	Rattus norvegicus	144-149
34964144-2	2022	The polysaccharide was isolated from M. charantia (MCP) and was characterized by using FTIR and LC-MS/MS.	Polysaccharides	4-18	CD46 molecule	Rattus norvegicus	51-54
34964144-10	2022	PRACTICAL APPLICATIONS: Polysaccharides extracted from Momordica charantia could normalize the level of blood glucose in STZ-induced type 2 diabetic rats through modulation of notch and angiogenesis singling pathways.	Polysaccharides	24-39	notch receptor 1	Rattus norvegicus	176-181
34964144-11	2022	Given that this effect was associated with the increased expression of Pdx-1 and Insulin in the pancreas, the isolated polysaccharide is expected to be introduced as a convenient medicine in the treatment of diabetes through modulation of beta-cell regeneration.	Polysaccharides	119-133	pancreatic and duodenal homeobox 1	Rattus norvegicus	71-76
34626776-9	2022	RESULTS: Our study revealed alkaloids, flavonoids, and polysaccharides in mulberry leaf could increase the levels of PK, HK, and ALT/GPT, and decrease the levels of TG and T-Cho significantly, and regulate glucose, amino acid, and lipid metabolism.	Polysaccharides	55-70	glutamic pyruvic transaminase, soluble	Mus musculus	129-132
34626776-9	2022	RESULTS: Our study revealed alkaloids, flavonoids, and polysaccharides in mulberry leaf could increase the levels of PK, HK, and ALT/GPT, and decrease the levels of TG and T-Cho significantly, and regulate glucose, amino acid, and lipid metabolism.	Polysaccharides	55-70	glutamic pyruvic transaminase, soluble	Mus musculus	133-136
34102146-4	2022	Results identified haptoglobin as the protein associated with HexNAc4-Hex5-NeuAc2, thus directly linking glycan imaging with intact glycopeptide identification.	Polysaccharides	105-111	haptoglobin	Canis lupus familiaris	19-30
34890647-3	2022	Complexes formed from the FcgammaRIa receptor and IgG1s containing biantennary glycans with N-acetylglucosamine, galactose, and alpha2,6-N-acetylneuraminic terminations were measured by hydrogen-deuterium exchange mass spectrometry (HDX-MS), classified for dissimilarity with Welch"s ANOVA and Games-Howell post hoc procedures, and modeled with molecular dynamics (MD) simulations.	Polysaccharides	79-86	Fc gamma receptor Ia	Homo sapiens	26-36
34890647-6	2022	These results indicate that IgG1-FcgammaRIa complexes are stabilized by intermolecular glycoprotein interactions between the IgG1 glycans and the 173KHR175 motif within the FG-loop of FcgammaRIa.	Polysaccharides	130-137	Fc gamma receptor Ia	Homo sapiens	33-43
34890647-6	2022	These results indicate that IgG1-FcgammaRIa complexes are stabilized by intermolecular glycoprotein interactions between the IgG1 glycans and the 173KHR175 motif within the FG-loop of FcgammaRIa.	Polysaccharides	130-137	Fc gamma receptor Ia	Homo sapiens	184-194
34910238-5	2022	Our results showed that the presence of the UDP-glucose 4-epimerase domain was beneficial for the production of digalactosylated complex-type glycans also when extracellular galactose was supplied, suggesting that the positive impact of the UDP-glucose 4-epimerase domain on the galactosylation process can be linked to other processes than its catalytic activity.	Polysaccharides	142-149	UDP-galactose-4-epimerase	Homo sapiens	44-67
34823789-0	2022	Novel pectin-like polysaccharide from Panax notoginseng attenuates renal tubular cells fibrogenesis induced by TGF-beta.	Polysaccharides	18-32	transforming growth factor alpha	Homo sapiens	111-119
34883069-0	2022	SARS-Cov-2 Spike binding to ACE2 is stronger and longer ranged due to glycan interaction.	Polysaccharides	70-76	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	11-16
34883069-0	2022	SARS-Cov-2 Spike binding to ACE2 is stronger and longer ranged due to glycan interaction.	Polysaccharides	70-76	angiotensin converting enzyme 2	Homo sapiens	28-32
34662214-4	2022	One hypothesis is that Salmonella can alter the electrical properties of the macrophages by modifying host cell surface glycan composition, which is supported by the fact that cleavage of surface-exposed sialic acids with a bacterial neuraminidase severely impairs macrophage galvanotaxis, as well as phagocytosis.	Polysaccharides	120-126	neuraminidase 1	Homo sapiens	234-247
34910238-5	2022	Our results showed that the presence of the UDP-glucose 4-epimerase domain was beneficial for the production of digalactosylated complex-type glycans also when extracellular galactose was supplied, suggesting that the positive impact of the UDP-glucose 4-epimerase domain on the galactosylation process can be linked to other processes than its catalytic activity.	Polysaccharides	142-149	UDP-galactose-4-epimerase	Homo sapiens	241-264
34458991-3	2022	One example is the 3E5 monoclonal murine IgG family, in which the mIgG3 isotype has different fine specificity to the Cryptococcus neoformans capsule polysaccharide than the other mIgG isotypes despite their identical variable sequences.	Polysaccharides	150-164	Immunoglobulin heavy constant gamma 3	Mus musculus	66-71
34742404-4	2022	Further, we show that homogeneous polysaccharide 37502 from the 375 may bind to 3CLpro well and disturb spike protein binding to ACE2 receptor.	Polysaccharides	34-48	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	104-109
34742404-4	2022	Further, we show that homogeneous polysaccharide 37502 from the 375 may bind to 3CLpro well and disturb spike protein binding to ACE2 receptor.	Polysaccharides	34-48	angiotensin converting enzyme 2	Homo sapiens	129-133
34801584-0	2022	PTP70-2, a novel polysaccharide from Polygala tenuifolia, prevents neuroinflammation and protects neurons by suppressing the TLR4-mediated MyD88/NF-kappaB signaling pathway.	Polysaccharides	17-31	toll-like receptor 4	Mus musculus	125-129
34873736-1	2022	In this study, two kinds of polysaccharides from leaves of Dendrobium officinale, namely DLP-1 and DLP-2, were obtained by hot water extraction, ethanol sedimentation, and chromatographic separation using DEAE-52 cellulose and Sephadex G-100 columns.	Polysaccharides	28-43	prenyl (solanesyl) diphosphate synthase, subunit 2	Mus musculus	89-94
34873736-11	2022	In order to maximize the value of D. officinale, this study aimed to investigate the structural characteristics and immunologic effects of two polysaccharide fractions (DLP-1 and DLP-2) from D. officinale leaves, showing that DLP-1 and DLP-2 in D. officinale leaves could be used as anti-inflammatory agents to avoid wasting.	Polysaccharides	143-157	prenyl (solanesyl) diphosphate synthase, subunit 2	Mus musculus	169-174
34738642-0	2022	Astragalus polysaccharide regulates brown adipocytes differentiation by miR-6911 targeting Prdm16.	Polysaccharides	11-25	PR domain containing 16	Mus musculus	91-97
34822830-0	2022	Physicochemical properties, antioxidant activities and alpha-glucosidase inhibitory effects of polysaccharides from Evodiae fructus extracted by different solvents.	Polysaccharides	95-110	sucrase-isomaltase	Homo sapiens	55-72
34822830-8	2022	Therefore, polysaccharides extracted by water and alkaline solvents from Evodiae fructus could be developed as promising natural antioxidants and alpha-glucosidase inhibitors in the food and medicine industries.	Polysaccharides	11-26	sucrase-isomaltase	Homo sapiens	146-163
34648684-0	2022	Polysaccharide-Protein Multilayers Based on Chitosan-Fibrinogen Assemblies for Cardiac Cell Engineering.	Polysaccharides	0-14	fibrinogen beta chain	Homo sapiens	53-63
34458991-7	2022	Also as observed with 3E5, 2H1-mIgG3 bound on ELISA to both acetylated and non-acetylated capsular polysaccharide, whereas 2H1-mIgG1 only bound well to the acetylated form, consistent with differences in fine specificity.	Polysaccharides	99-113	Immunoglobulin heavy constant gamma 3	Mus musculus	31-36
34837761-2	2022	Glycyrrhiza Polysaccharides (GPS-1) are water-soluble neutral polysaccharides extracted from licorice.	Polysaccharides	62-77	G protein pathway suppressor 1	Gallus gallus	29-34
34939113-3	2022	Here, we expand the capabilities of our platform to carry out sialylation and demonstrate the high-yielding production of human interferon alpha2b and human growth hormone bearing mono- and disialylated T-antigen glycans.	Polysaccharides	213-220	interferon alpha 2	Homo sapiens	128-146
34217596-2	2022	An important factor in this symbiosis is the interplay between microbes and human-produced glycans in mucin and breast milk.	Polysaccharides	91-98	LOC100508689	Homo sapiens	102-107
34965524-8	2022	By decision curve analysis, there was a 3.45% net benefit by adding urinary glycan intensity of ACA to the reference standard at the predefined threshold probability of 40%.	Polysaccharides	76-82	T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	Homo sapiens	38-41
34965524-10	2022	C1GALT1 and COSMC were responsible for the biosynthesis of these glycans, and they were known to be downregulated in IgAN.	Polysaccharides	65-72	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	0-7
34965524-10	2022	C1GALT1 and COSMC were responsible for the biosynthesis of these glycans, and they were known to be downregulated in IgAN.	Polysaccharides	65-72	C1GALT1 specific chaperone 1	Homo sapiens	12-17
34270745-7	2021	Our results provide a novel example of glycans as signaling molecules and shed light on the pathophysiological roles of ALK.	Polysaccharides	39-46	ALK receptor tyrosine kinase	Homo sapiens	120-123
34952645-3	2021	DC-SIGN binds variously crosslinked mannose-rich and fucosylated glycans and lipomannans that are expressed by helminth, protist, fungal, bacterial and viral pathogens including three of the most life-threatening fungi, Aspergillus fumigatus, Candida albicans and Cryptococcus neoformans.	Polysaccharides	65-72	CD209a antigen	Mus musculus	0-7
34936535-5	2022	In addition, we identify a polysaccharide which causes the degradation of OLR1 and suppresses this autophagic pathway to inhibit tumorigenesis.	Polysaccharides	27-41	oxidized low density lipoprotein receptor 1	Homo sapiens	74-78
34781737-8	2021	Further investigation on the identity of fungal molecular patterns has revealed that the cell wall polysaccharides beta-(1, 3)-glucan and alpha-(1, 3)-glucan, but not chitin, possess the capacity to activate the beta-catenin pathway.	Polysaccharides	99-114	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	115-125
34781737-8	2021	Further investigation on the identity of fungal molecular patterns has revealed that the cell wall polysaccharides beta-(1, 3)-glucan and alpha-(1, 3)-glucan, but not chitin, possess the capacity to activate the beta-catenin pathway.	Polysaccharides	99-114	catenin beta 1	Homo sapiens	212-224
34781737-14	2021	Dissection of the identity of A. fumigatus pathogen-associated molecular patterns (PAMPs) revealed that cell wall polysaccharides exhibit selectivity in their capacity to activate the beta-catenin pathway in DCs.	Polysaccharides	114-129	catenin beta 1	Homo sapiens	184-196
34931005-6	2021	Consequently, CXCL4 alters the glycan-binding affinity and specificity of galectin-1.	Polysaccharides	31-37	platelet factor 4	Homo sapiens	14-19
34931005-6	2021	Consequently, CXCL4 alters the glycan-binding affinity and specificity of galectin-1.	Polysaccharides	31-37	galectin 1	Homo sapiens	74-84
34927506-0	2022	Novel polysaccharide building hybrid nanoparticles: remodeling TAMs to target ERalpha-positive breast cancer.	Polysaccharides	6-20	estrogen receptor 1	Homo sapiens	78-85
34270745-3	2021	Recent biochemical work showed that heparan sulfate (HS), an unbranched sulfated glycan, acts as a ligand for and activates ALK.	Polysaccharides	81-87	ALK receptor tyrosine kinase	Homo sapiens	124-127
34968544-1	2022	In the work, a novel filamentou sodium alginate (SA) /epsilon-polylysine (PL) fiber with excellent mechanical properties and controllable sizes is prepared in an efficient and environmentally friendly manner via continuous pulling of an electrostatically assembled SA/PL composites at the contact interface of aqueous solutions of cationic polyelectrolyte epsilon-PL and anionic natural polysaccharide SA.	Polysaccharides	387-401	acyl-CoA synthetase medium-chain family member 3	Mus musculus	49-51
34968544-1	2022	In the work, a novel filamentou sodium alginate (SA) /epsilon-polylysine (PL) fiber with excellent mechanical properties and controllable sizes is prepared in an efficient and environmentally friendly manner via continuous pulling of an electrostatically assembled SA/PL composites at the contact interface of aqueous solutions of cationic polyelectrolyte epsilon-PL and anionic natural polysaccharide SA.	Polysaccharides	387-401	acyl-CoA synthetase medium-chain family member 3	Mus musculus	265-270
34968544-1	2022	In the work, a novel filamentou sodium alginate (SA) /epsilon-polylysine (PL) fiber with excellent mechanical properties and controllable sizes is prepared in an efficient and environmentally friendly manner via continuous pulling of an electrostatically assembled SA/PL composites at the contact interface of aqueous solutions of cationic polyelectrolyte epsilon-PL and anionic natural polysaccharide SA.	Polysaccharides	387-401	acyl-CoA synthetase medium-chain family member 3	Mus musculus	402-404
34976303-0	2021	Microglia Polarization from M1 toward M2 Phenotype Is Promoted by Astragalus Polysaccharides Mediated through Inhibition of miR-155 in Experimental Autoimmune Encephalomyelitis.	Polysaccharides	77-92	microRNA 155	Mus musculus	124-131
34903045-3	2021	Here, we show that bacteriophage N4 exploits a novel surface glycan (NGR) as a receptor to infect its host Escherichia coli.	Polysaccharides	61-67	reticulon 4 receptor	Homo sapiens	69-72
34939113-3	2022	Here, we expand the capabilities of our platform to carry out sialylation and demonstrate the high-yielding production of human interferon alpha2b and human growth hormone bearing mono- and disialylated T-antigen glycans.	Polysaccharides	213-220	growth hormone 1	Homo sapiens	157-171
34949747-4	2022	In this study, crude polysaccharides (GBP) were isolated from Korean ginseng berries and their immunomodulatory activities were investigated using cyclophosphamide (CY)-induced immunosuppressive BALB/c mice.	Polysaccharides	21-36	protein inhibitor of activated STAT 1	Mus musculus	38-41
34384968-7	2021	Pearson correlation concluded that the dominant signal molecule C4-HSL was the specific AHL in enhancing the synthesis of extracellular polysaccharide and the metabolism of acidogens.	Polysaccharides	136-150	lipase E, hormone sensitive type	Homo sapiens	67-70
34767882-8	2021	Moreover, a number of signalling pathways, such as the Wnt/beta-catenin signalling pathway, BMP/SMAD/RUNX2 signalling pathway, OPG/RANKL/RANK signalling pathway, apoptosis pathway, and transcription factors, are regulated by polysaccharides and participate in improving bone homeostasis.	Polysaccharides	225-240	catenin beta 1	Homo sapiens	59-71
34767882-8	2021	Moreover, a number of signalling pathways, such as the Wnt/beta-catenin signalling pathway, BMP/SMAD/RUNX2 signalling pathway, OPG/RANKL/RANK signalling pathway, apoptosis pathway, and transcription factors, are regulated by polysaccharides and participate in improving bone homeostasis.	Polysaccharides	225-240	RUNX family transcription factor 2	Homo sapiens	101-106
34767882-8	2021	Moreover, a number of signalling pathways, such as the Wnt/beta-catenin signalling pathway, BMP/SMAD/RUNX2 signalling pathway, OPG/RANKL/RANK signalling pathway, apoptosis pathway, and transcription factors, are regulated by polysaccharides and participate in improving bone homeostasis.	Polysaccharides	225-240	basic transcription factor 3 pseudogene 11	Homo sapiens	127-130
34767882-8	2021	Moreover, a number of signalling pathways, such as the Wnt/beta-catenin signalling pathway, BMP/SMAD/RUNX2 signalling pathway, OPG/RANKL/RANK signalling pathway, apoptosis pathway, and transcription factors, are regulated by polysaccharides and participate in improving bone homeostasis.	Polysaccharides	225-240	TNF superfamily member 11	Homo sapiens	131-136
34718370-0	2021	Astragalus polysaccharide regulates brown adipogenic differentiation through miR-1258-5p-modulated cut-like homeobox 1 expression.	Polysaccharides	11-25	microRNA 1258	Mus musculus	77-85
34944886-1	2021	Beta glucans, complex polysaccharides, prime leukocyte dectin-1 and CR3-receptors and enhance anti-tumor cytotoxicity of complement-activating monoclonal antibodies.	Polysaccharides	22-37	C-type lectin domain containing 7A	Homo sapiens	55-63
34966769-1	2021	The present study investigated whether the purified polysaccharide from Cereus sinensis (CSP-1) had beneficial effects on mice with antibiotic-associated diarrhea (AAD).	Polysaccharides	52-66	regulator of calcineurin 1	Mus musculus	89-94
34966782-0	2021	The Cordyceps militaris-Derived Polysaccharide CM1 Alleviates Atherosclerosis in LDLR(-/-) Mice by Improving Hyperlipidemia.	Polysaccharides	32-46	low density lipoprotein receptor	Mus musculus	81-85
34993358-0	2021	Mucin-mimetic glycan arrays integrating machine learning for analyzing receptor pattern recognition by influenza A viruses.	Polysaccharides	14-20	LOC100508689	Homo sapiens	0-5
34718370-0	2021	Astragalus polysaccharide regulates brown adipogenic differentiation through miR-1258-5p-modulated cut-like homeobox 1 expression.	Polysaccharides	11-25	cut-like homeobox 1	Mus musculus	99-118
34878920-1	2022	Glycans on envelope glycoprotein (Env) of the subgroup J avian leukosis virus (ALV-J) play an essential role in virion integrity and infection process.	Polysaccharides	0-7	endogenous retrovirus group K member 6, envelope	Homo sapiens	11-32
34880222-5	2021	We also demonstrate that DC-SIGN, unlike MR and Dectin-2, recognises planktonic P. aeruginosa cultures and this interaction depends on the presence of the common polysaccharide antigen.	Polysaccharides	162-176	CD209 molecule	Homo sapiens	25-32
34878920-1	2022	Glycans on envelope glycoprotein (Env) of the subgroup J avian leukosis virus (ALV-J) play an essential role in virion integrity and infection process.	Polysaccharides	0-7	endogenous retrovirus group K member 6, envelope	Homo sapiens	34-37
34390795-12	2021	The polysaccharides activate the RAW264.7 cell to produce a significant amount of NO and upregulate the various mRNA expression by the activation of MAPK and NF-kappaB pathways via TLR4, TLR2, and CR3 receptors.	Polysaccharides	4-19	toll-like receptor 4	Mus musculus	181-185
34963738-12	2021	For monitoring patients with AFP-negative HCC, a unique trifucosylated tetra-antennary glycan of ORM may also be used as a new potential marker.	Polysaccharides	87-93	alpha fetoprotein	Homo sapiens	29-32
34963738-12	2021	For monitoring patients with AFP-negative HCC, a unique trifucosylated tetra-antennary glycan of ORM may also be used as a new potential marker.	Polysaccharides	87-93	orosomucoid 1	Homo sapiens	97-100
34390795-12	2021	The polysaccharides activate the RAW264.7 cell to produce a significant amount of NO and upregulate the various mRNA expression by the activation of MAPK and NF-kappaB pathways via TLR4, TLR2, and CR3 receptors.	Polysaccharides	4-19	toll-like receptor 2	Mus musculus	187-191
34390795-15	2021	CONCLUSIONS: The present study demonstrated that the polysaccharide isolated from T. platycarpum shows admirable immunostimulatory by the activation of MAPK and NF-kappaB pathways through TLR4, TLR2, and CR3 receptors.	Polysaccharides	53-67	toll-like receptor 4	Mus musculus	188-192
34390795-15	2021	CONCLUSIONS: The present study demonstrated that the polysaccharide isolated from T. platycarpum shows admirable immunostimulatory by the activation of MAPK and NF-kappaB pathways through TLR4, TLR2, and CR3 receptors.	Polysaccharides	53-67	toll-like receptor 2	Mus musculus	194-198
34686894-11	2021	This method could be applied for the Apo-H glycan profiling of large clinical cohorts for diagnostic purposes.	Polysaccharides	43-49	apolipoprotein H	Homo sapiens	37-42
34925381-0	2021	Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants.	Polysaccharides	0-6	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	53-58
34864058-7	2022	Additionally, we find that IL-22 signaling regulates levels of the alpha1-3-fucosylated Lewis X (Lex) blood group antigen, and that this glycan epitope is primarily displayed on O-glycosylated intestinal epithelial glycoproteins.	Polysaccharides	137-143	interleukin 22	Homo sapiens	27-32
34327564-4	2021	Most of the glycans were derived from the recombinant glycoproteins gp120 and gp41 from the human immunodeficiency virus (HIV), recombinantly derived from human embryonic kidney (HEK 293T) cells.	Polysaccharides	12-19	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	68-73
34772579-0	2021	Retraction notice to "Astragalus polysaccharide promotes proliferation and osteogenic differentiation of bone mesenchymal stem cells by down-regulation of microRNA-152" (Biomed.	Polysaccharides	33-47	microRNA 152	Homo sapiens	155-168
34699323-16	2021	In conclusion, astragalus polysaccharide treatment improved proliferation and insulin secretion in HG+PA-treated MIN6 cells partially by promoting miR-136-5p and miR-149-5p expression to inhibit EFHD2 expression.	Polysaccharides	26-40	insulin	Homo sapiens	78-85
34699323-16	2021	In conclusion, astragalus polysaccharide treatment improved proliferation and insulin secretion in HG+PA-treated MIN6 cells partially by promoting miR-136-5p and miR-149-5p expression to inhibit EFHD2 expression.	Polysaccharides	26-40	microRNA 149	Mus musculus	162-169
34699323-16	2021	In conclusion, astragalus polysaccharide treatment improved proliferation and insulin secretion in HG+PA-treated MIN6 cells partially by promoting miR-136-5p and miR-149-5p expression to inhibit EFHD2 expression.	Polysaccharides	26-40	EF hand domain containing 2	Mus musculus	195-200
34699323-0	2021	Astragalus polysaccharide improve the proliferation and insulin secretion of mouse pancreatic beta cells induced by high glucose and palmitic acid partially through promoting miR-136-5p and miR-149-5p expression.	Polysaccharides	11-25	insulin	Homo sapiens	56-63
34699323-0	2021	Astragalus polysaccharide improve the proliferation and insulin secretion of mouse pancreatic beta cells induced by high glucose and palmitic acid partially through promoting miR-136-5p and miR-149-5p expression.	Polysaccharides	11-25	microRNA 149	Mus musculus	190-197
34699323-12	2021	Silencing of miR-136-5p and miR-149-5p expression partially reversed the therapeutic effects of astragalus polysaccharide.	Polysaccharides	107-121	microRNA 149	Mus musculus	28-35
34699323-14	2021	Meanwhile, astragalus polysaccharide treatment inhibited EFHD2 protein level in HG+PA treated MIN6 cell.	Polysaccharides	22-36	EF hand domain containing 2	Mus musculus	57-62
34699323-15	2021	Finally, EFHD2 overexpression partially reversed the therapeutic effects of astragalus polysaccharide.	Polysaccharides	87-101	EF hand domain containing 2	Mus musculus	9-14
34731252-4	2021	By engaging surface glycans, the bacterial lectin activated human peripheral blood B cells, which manifested in the surface expression of CD69, CD54 and CD86 but became increasingly cytotoxic at higher concentrations.	Polysaccharides	20-27	CD69 molecule	Homo sapiens	138-142
34731252-4	2021	By engaging surface glycans, the bacterial lectin activated human peripheral blood B cells, which manifested in the surface expression of CD69, CD54 and CD86 but became increasingly cytotoxic at higher concentrations.	Polysaccharides	20-27	intercellular adhesion molecule 1	Homo sapiens	144-148
34851004-0	2022	Sulfation pattern dependent Iron (III) mediated interleukin-8 glycan binding.	Polysaccharides	62-68	C-X-C motif chemokine ligand 8	Homo sapiens	48-61
34731252-4	2021	By engaging surface glycans, the bacterial lectin activated human peripheral blood B cells, which manifested in the surface expression of CD69, CD54 and CD86 but became increasingly cytotoxic at higher concentrations.	Polysaccharides	20-27	CD86 molecule	Homo sapiens	153-157
34784711-2	2021	The amount of resistant starch (RS) was significantly lowered in the water-soluble polysaccharide (WSP), water-soluble polysaccharide-pectinase (WSP-P), and water-insoluble polysaccharide-alkali soluble (WISP-Alk-Soluble; p < 0.05).	Polysaccharides	173-187	sorting nexin 9	Homo sapiens	204-208
34597702-0	2021	Structural characterization of polysaccharide from yellow sweet potato and ameliorates DSS-induced mice colitis by active GPR41/MEK/ERK 1/2 signaling pathway.	Polysaccharides	31-45	free fatty acid receptor 3	Mus musculus	122-127
34597702-0	2021	Structural characterization of polysaccharide from yellow sweet potato and ameliorates DSS-induced mice colitis by active GPR41/MEK/ERK 1/2 signaling pathway.	Polysaccharides	31-45	midkine	Mus musculus	128-131
34597702-0	2021	Structural characterization of polysaccharide from yellow sweet potato and ameliorates DSS-induced mice colitis by active GPR41/MEK/ERK 1/2 signaling pathway.	Polysaccharides	31-45	mitogen-activated protein kinase 3	Mus musculus	132-139
34278967-2	2021	S protein is heavily glycosylated and the glycosylation sites are relatively conserved, thus glycans on S protein surface could be a target for development of anti-SARS-CoV-2 strategies against variants.	Polysaccharides	93-100	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	0-1
34678381-8	2021	Up to the present, polysaccharides-based nanoparticles have been widely applied for tumor treatment, antibacterial application, gene therapy, photodynamic therapy and transporting insulin.	Polysaccharides	19-34	insulin	Homo sapiens	180-187
34787328-1	2021	polysaccharides improve type 2 diabetes in HFD/STZ-induced mice by regulating the AKT/AMPK signaling pathways and the gut microbiota.	Polysaccharides	0-15	thymoma viral proto-oncogene 1	Mus musculus	82-85
34285147-6	2021	RESULTS: We identified and replicated four glycan traits, incidence of bisecting GlcNAc, GP4, GP9 and GP21, that are predictive of incident hypertension after adjusting for confoundes and multiple testing (hazard ratio (95% CI) ranging from 0.45 (0.24-0.84) for GP21 to 2.9 (1.5-5.68) for GP4).	Polysaccharides	43-49	glycoprotein IX platelet	Homo sapiens	94-97
34872988-7	2021	Neuraminidase 1 (NEU1), the most predominant protein in the pathway of other glycan degradation, was highly expressed in the kidney of patients with proliferative LN and could co-localise with podocyte, mesangial cells, endothelial cells and tubule cells.	Polysaccharides	77-83	neuraminidase 1	Homo sapiens	0-15
34285147-6	2021	RESULTS: We identified and replicated four glycan traits, incidence of bisecting GlcNAc, GP4, GP9 and GP21, that are predictive of incident hypertension after adjusting for confoundes and multiple testing (hazard ratio (95% CI) ranging from 0.45 (0.24-0.84) for GP21 to 2.9 (1.5-5.68) for GP4).	Polysaccharides	43-49	CD36 molecule	Homo sapiens	289-292
34285147-7	2021	We then linearly combined the four replicated glycans and found that the glycan score correlated with incident hypertension, SBP and DBP.	Polysaccharides	73-79	selenium binding protein 1	Homo sapiens	125-128
34285147-7	2021	We then linearly combined the four replicated glycans and found that the glycan score correlated with incident hypertension, SBP and DBP.	Polysaccharides	73-79	D-box binding PAR bZIP transcription factor	Homo sapiens	133-136
34872988-7	2021	Neuraminidase 1 (NEU1), the most predominant protein in the pathway of other glycan degradation, was highly expressed in the kidney of patients with proliferative LN and could co-localise with podocyte, mesangial cells, endothelial cells and tubule cells.	Polysaccharides	77-83	neuraminidase 1	Homo sapiens	17-21
34788022-4	2021	The gas-phase derivatization strategy provides a rapid way to manipulate the ion-types of the precursor ions, and, in conjunction with collision induced dissociation (CID), allows for the elucidation of the structures of the glycan moieties from gangliosides.	Polysaccharides	225-231	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	4-7
34788022-14	2021	The results demonstrate the applicability and strength of using shotgun MS coupled with gas-phase ion/ion chemistry to characterize the glycan moiety structures on different subclasses of gangliosides.	Polysaccharides	136-142	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	88-91
34877528-3	2021	Infrared (IR) spectroscopy is a well-established technique which has been widely applied in polysaccharide structural analysis.	Polysaccharides	92-106	insulin receptor	Homo sapiens	10-12
34592222-2	2021	The aim of this study was to explore the interaction mechanism between Lentinus edodes mycelia polysaccharide (LMP) and bovine lactoferrin (BLF), and the activity of LMP-BLF complex to inhibit oxidative stress in islet beta cells.	Polysaccharides	95-109	lactotransferrin	Bos taurus	127-138
34884718-8	2021	We found that the polysaccharide and its oligosaccharides strongly reduced the transduction efficiency of lentiviral particles pseudotyped with GP160-the envelope protein of the human immunodeficiency virus HIV-1-when added to T-lymphocyte Jurkat cells.	Polysaccharides	18-32	glutamyl aminopeptidase	Homo sapiens	144-149
34836981-5	2021	Gal-1 is the one of lectin receptor which can bind to glycan.	Polysaccharides	54-60	galectin 1	Homo sapiens	0-5
34959287-3	2021	Based on its bilayer coating of polysaccharides, Cel/PT-LbL Lipo alleviated cytotoxicity of celastrol in colon epithelial NCM460 cells.	Polysaccharides	32-47	carboxyl ester lipase	Homo sapiens	49-52
34817689-11	2021	It was also shown that the presence of various glycosylation sites within the ErbB2 growth factor binding site leads to occlusion of this site by the glycans that inhibit ligand binding to ErbB2 and participate in further stabilization of the heterodimer construct.	Polysaccharides	150-157	erb-b2 receptor tyrosine kinase 2	Homo sapiens	189-194
34549974-9	2021	BMS-806 treatment decreased both gp160 cleavage and the addition of complex glycans, implying that gp160 conformational flexibility contributes to the efficiency of these processes.	Polysaccharides	76-83	glutamyl aminopeptidase	Homo sapiens	99-104
34537295-1	2021	The derivatization of chitosan (CS) is widely exploited to endow this polysaccharide with enhanced physicochemical and biological properties.	Polysaccharides	70-84	citrate synthase	Homo sapiens	32-34
34884718-3	2021	The composition and distribution of the repetition units of kappa/beta- CRG were investigated by using the negative ion tandem MALDI-TOFMS and ESIMS method, which made it possible to prove and characterize the hybrid structure of this polysaccharide.	Polysaccharides	235-249	chromodomain helicase DNA binding protein 7	Homo sapiens	72-75
34959847-2	2021	An established modified citrus pectin (PectaSol , P-MCP), a dietary polysaccharide, is an established antagonist of galectin-3, a carbohydrate-binding protein involved in cancer pathogenesis.	Polysaccharides	68-82	CD46 molecule	Homo sapiens	52-55
34959847-2	2021	An established modified citrus pectin (PectaSol , P-MCP), a dietary polysaccharide, is an established antagonist of galectin-3, a carbohydrate-binding protein involved in cancer pathogenesis.	Polysaccharides	68-82	galectin 3	Homo sapiens	116-126
34877528-4	2021	In this paper, the principle of IR and interpretation of polysaccharide IR spectrum are briefly introduced.	Polysaccharides	57-71	insulin receptor	Homo sapiens	32-34
34877528-4	2021	In this paper, the principle of IR and interpretation of polysaccharide IR spectrum are briefly introduced.	Polysaccharides	57-71	insulin receptor	Homo sapiens	72-74
34877528-5	2021	Classical applications of IR spectroscopy in polysaccharide structural elucidation are reviewed from qualitative and quantitative aspects.	Polysaccharides	45-59	insulin receptor	Homo sapiens	26-28
34877528-8	2021	Overall, this review seeks to provide a comprehensive insight to applications of IR spectroscopy in polysaccharide structural analysis and highlights the importance of advanced IR-integrating techniques.	Polysaccharides	100-114	insulin receptor	Homo sapiens	81-83
34869209-3	2021	Recent studies show that spike protein glycans play critical roles in viral entry and infection.	Polysaccharides	39-46	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	25-30
34709792-6	2021	In the context of beta-glucan structures and their effects on human nutrition and health, we summarize here the functional characterization of individual polysaccharide utilization loci (PULs) responsible for the saccharification of mixed-linkage beta(1 3)/beta(1 4)-glucans, beta(1 6)-glucans, beta(1 3)-glucans, beta(1 2)-glucans, and xyloglucans in symbiotic human gut bacteria.	Polysaccharides	154-168	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	247-255
34709792-6	2021	In the context of beta-glucan structures and their effects on human nutrition and health, we summarize here the functional characterization of individual polysaccharide utilization loci (PULs) responsible for the saccharification of mixed-linkage beta(1 3)/beta(1 4)-glucans, beta(1 6)-glucans, beta(1 3)-glucans, beta(1 2)-glucans, and xyloglucans in symbiotic human gut bacteria.	Polysaccharides	154-168	immunoglobulin kappa variable 6D-41 (non-functional)	Homo sapiens	257-265
34709792-6	2021	In the context of beta-glucan structures and their effects on human nutrition and health, we summarize here the functional characterization of individual polysaccharide utilization loci (PULs) responsible for the saccharification of mixed-linkage beta(1 3)/beta(1 4)-glucans, beta(1 6)-glucans, beta(1 3)-glucans, beta(1 2)-glucans, and xyloglucans in symbiotic human gut bacteria.	Polysaccharides	154-168	immunoglobulin kappa variable 3-31 (pseudogene)	Homo sapiens	276-284
34709792-6	2021	In the context of beta-glucan structures and their effects on human nutrition and health, we summarize here the functional characterization of individual polysaccharide utilization loci (PULs) responsible for the saccharification of mixed-linkage beta(1 3)/beta(1 4)-glucans, beta(1 6)-glucans, beta(1 3)-glucans, beta(1 2)-glucans, and xyloglucans in symbiotic human gut bacteria.	Polysaccharides	154-168	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	295-303
34709792-6	2021	In the context of beta-glucan structures and their effects on human nutrition and health, we summarize here the functional characterization of individual polysaccharide utilization loci (PULs) responsible for the saccharification of mixed-linkage beta(1 3)/beta(1 4)-glucans, beta(1 6)-glucans, beta(1 3)-glucans, beta(1 2)-glucans, and xyloglucans in symbiotic human gut bacteria.	Polysaccharides	154-168	immunoglobulin kappa variable 2D-19 (pseudogene)	Homo sapiens	314-322
34869209-16	2021	SARS-CoV-2 spike glycans are associated with host ACE2 receptor interaction efficiency.	Polysaccharides	17-24	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	11-16
34869209-16	2021	SARS-CoV-2 spike glycans are associated with host ACE2 receptor interaction efficiency.	Polysaccharides	17-24	angiotensin converting enzyme 2	Homo sapiens	50-54
34748320-3	2021	Using heteromultivalent liposomes copresenting mannosides bearing aromatic aglycones with natural glycan ligands, we serendipitously discovered striking cooperativity effects for DC-SIGN+ but not for Langerin+ cell lines.	Polysaccharides	98-104	CD209 molecule	Homo sapiens	179-186
34192302-5	2021	In this study, we analyzed site-specific N-glycan structures of serum M2BP using Glyco-RIDGE (Glycan heterogeneity-based Relational IDentification of Glycopeptide signals on Elution profile) method.	Polysaccharides	94-100	galectin 3 binding protein	Homo sapiens	70-74
34832408-2	2021	In this study, a hydrophobic moiety, deoxycholic acid (DCA) was first bonded on a polysaccharide, chitosan (CS), for the preparation of amphiphilic chitosan (CS-DCA), which was further modified with a cationic glycidyltrimethylammounium chloride (GTMAC) to form a novel soluble chitosan derivative (HT-CS-DCA).	Polysaccharides	82-96	citrate synthase	Homo sapiens	108-110
34832408-2	2021	In this study, a hydrophobic moiety, deoxycholic acid (DCA) was first bonded on a polysaccharide, chitosan (CS), for the preparation of amphiphilic chitosan (CS-DCA), which was further modified with a cationic glycidyltrimethylammounium chloride (GTMAC) to form a novel soluble chitosan derivative (HT-CS-DCA).	Polysaccharides	82-96	citrate synthase	Homo sapiens	158-160
34748320-6	2021	We further present preliminary evidence that the aglycone allosterically activates glycan recognition and thereby contributes to DC-SIGN-specific cell targeting.	Polysaccharides	83-89	CD209 molecule	Homo sapiens	129-136
34803391-4	2021	Mucin-type O-glycans alter the diversity of gastrointestinal microorganisms, which in turn increases the level of O-glycosylation of host intestinal proteins via the utilization of glycans.	Polysaccharides	181-188	LOC100508689	Homo sapiens	0-5
34784973-10	2021	Finally, mono-colonization of Bifidobacterium with a specific polysaccharide utilization locus impacts the alternative splicing of the gluR-B gene, which is associated with an increased GABA level in the brain.	Polysaccharides	62-76	metabotropic glutamate receptor B	Apis mellifera	135-141
34711323-4	2021	Owing to the complexity of the intact protein, information about EPO glycosylation is commonly derived from released glycan and glycopeptide analysis using mass spectrometry (MS).	Polysaccharides	117-123	erythropoietin	Homo sapiens	65-68
34562468-0	2021	Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway.	Polysaccharides	11-25	NFE2 like bZIP transcription factor 2	Homo sapiens	127-131
34562468-0	2021	Astragalus polysaccharide prevents ferroptosis in a murine model of experimental colitis and human Caco-2 cells via inhibiting NRF2/HO-1 pathway.	Polysaccharides	11-25	heme oxygenase 1	Homo sapiens	132-136
34779975-0	2021	Role of sialylated glycans on bovine lactoferrin against influenza virus.	Polysaccharides	19-26	lactotransferrin	Bos taurus	37-48
34766864-4	2021	Cold plasma (CP), as an innovative and highly efficient technology, has been introduced to improve the performance of polysaccharides and proteins-based films.	Polysaccharides	118-133	ceruloplasmin	Homo sapiens	13-15
34766864-5	2021	This review mainly presents the basic information of polysaccharides and proteins-based films, principles of CP modified biopolymer films, and the effects of CP on the structural changes including surface morphology, surface composition, and bulk modification, and properties including wettability, mechanical properties, barrier properties, and thermal properties of polysaccharides, proteins, and polysaccharide/protein composite-based films.	Polysaccharides	368-383	ceruloplasmin	Homo sapiens	158-160
34266346-4	2021	This is exemplified by GPVI, CLEC-2 and PEAR1 which are activated by a wide spectrum of endogenous and exogenous ligands, including diesel exhaust particles, sulfated polysaccharides and charged surfaces.	Polysaccharides	167-182	glycoprotein VI platelet	Homo sapiens	23-27
34266346-4	2021	This is exemplified by GPVI, CLEC-2 and PEAR1 which are activated by a wide spectrum of endogenous and exogenous ligands, including diesel exhaust particles, sulfated polysaccharides and charged surfaces.	Polysaccharides	167-182	C-type lectin domain family 1 member B	Homo sapiens	29-35
34266346-4	2021	This is exemplified by GPVI, CLEC-2 and PEAR1 which are activated by a wide spectrum of endogenous and exogenous ligands, including diesel exhaust particles, sulfated polysaccharides and charged surfaces.	Polysaccharides	167-182	platelet endothelial aggregation receptor 1	Homo sapiens	40-45
34766864-6	2021	It is concluded that the CP modified performances are mainly depending on the polysaccharides and proteins raw materials, CP generation types and treatment conditions.	Polysaccharides	78-93	ceruloplasmin	Homo sapiens	25-27
34762717-2	2021	Siglec-9 restrains NK cytotoxicity by binding to sialoglycans (sialic acid-containing glycans) on target cells.	Polysaccharides	86-93	sialic acid binding Ig like lectin 9	Homo sapiens	0-8
34787291-0	2021	Astragalus polysaccharide attenuates overexercise-induce myocardial injury via activating AMPK signaling pathway to suppress inflammation and oxidative stress.	Polysaccharides	11-25	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	90-94
34689907-1	2021	We present in this study a novel strategy to drastically improve the detection sensitivity and peak capacity for capillary electrophoresis with laser induced fluorescent detection (CE-LIF) of glucose oligomers and released glycans.	Polysaccharides	223-230	LIF interleukin 6 family cytokine	Homo sapiens	184-187
34859057-3	2021	We employed labelled glycans to explore the conformational behaviour of a beta(1-6)-Glc hexasaccharide model through residual dipolar couplings (RDCs).	Polysaccharides	21-28	immunoglobulin kappa variable 3-31 (pseudogene)	Homo sapiens	74-82
34819927-1	2021	Deoxythymidine diphospho-l-rhamnose (dTDP-l-rhamnose) is used by prokaryotic rhamnosyltransferases as the glycosyl donor for the synthesis of rhamnose-containing polysaccharides and compounds that have potential in pharmaceutical development, so its efficient synthesis has attracted much attention.	Polysaccharides	162-177	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	37-41
34689907-2	2021	This is based on a new approach exploiting a polymer-free background electrolyte (BGE) for CE-LIF of glycans.	Polysaccharides	101-108	LIF interleukin 6 family cytokine	Homo sapiens	94-97
34509627-0	2021	Astragalus membranaceus polysaccharides modulates growth, haemato-biochemical indexes, hepatic antioxidants, and expression of HSP70 and apoptosis-related genes in Oreochromis niloticus exposed to sub-lethal thallium toxicity.	Polysaccharides	24-39	heat shock cognate 71 kDa protein	Oreochromis niloticus	127-132
34803940-0	2021	Glycan Biosynthesis Ability of Gut Microbiota Increased in Primary Hypertension Patients Taking Antihypertension Medications and Potentially Promoted by Macrophage-Adenosine Monophosphate-Activated Protein Kinase.	Polysaccharides	0-6	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	164-212
34803940-8	2021	We found that the changes in E. coli and Dorea and glycan biosynthesis-related orthologs and pathways were similar in our cohort and hypertensive wild-type mice but reversed after AMPK knockout.	Polysaccharides	51-57	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	180-184
34481155-1	2021	Ligands with the polysaccharide headgroups have been recently reported by our group to possess enhanced interaction with asialoglycoprotein receptor (ASGPR) in silico as compared to ligands having galactose moieties.	Polysaccharides	17-31	asialoglycoprotein receptor 1	Homo sapiens	121-148
34481155-1	2021	Ligands with the polysaccharide headgroups have been recently reported by our group to possess enhanced interaction with asialoglycoprotein receptor (ASGPR) in silico as compared to ligands having galactose moieties.	Polysaccharides	17-31	asialoglycoprotein receptor 1	Homo sapiens	150-155
34077620-3	2021	One prominent attribute of ZG16 is its ability to bind glycans, but other aspects of the protein may also contribute to activity.	Polysaccharides	55-62	zymogen granule protein 16	Homo sapiens	27-31
34077620-7	2021	ZG16 crystal structures also draw attention to a non-proline cis peptide bond that can isomerize within the protein and to the mobility of glycine-rich loops in the glycan-binding site.	Polysaccharides	165-171	zymogen granule protein 16	Homo sapiens	0-4
34077620-8	2021	An understanding of the properties of the ZG16 CXXC motif and the discovery of internal conformational switches extend existing knowledge relating to the glycan-binding activity of the protein.	Polysaccharides	154-160	zymogen granule protein 16	Homo sapiens	42-46
34731616-2	2021	To understand how this glycan can be recognized, here we isolate two lineages of glycan276-dependent CD4bs antibodies.	Polysaccharides	23-29	CD4 molecule	Homo sapiens	101-104
34625256-3	2021	In this paper we report on the development and implementation of a high-throughput capillary electrophoresis based glycan analysis workflow for urinary PSA analysis.	Polysaccharides	115-121	kallikrein related peptidase 3	Homo sapiens	152-155
34651208-0	2021	Discrimination of sulfated isomers of chondroitin sulfate disaccharides by HILIC-MS. Chondroitin sulfate (CS) glycosaminoglycans are biologically active sulfated polysaccharides that pose an analytical challenge for their structural analysis and functional evaluation.	Polysaccharides	162-177	citrate synthase	Homo sapiens	106-108
34509627-1	2021	A 60-day experiment was performed to assess the efficacy of dietary Astragalus membranaceus polysaccharides (ASP) in attenuation of thallium (Tl) induced toxicity in Nile tilapia.	Polysaccharides	92-107	fibrous sheath CABYR-binding protein	Oreochromis niloticus	109-112
34699642-9	2021	We propose that the densely clustered, sialylated glycans on the SCS floor LEC are a key component of the macrophage niche, providing anchorage for the Siglec-1+ LN-SCS macrophages.	Polysaccharides	50-57	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	152-160
34632911-2	2021	While effective, cetuximab is associated with a higher rate of skin rash, infusion reactions, and gastrointestinal toxicity, which was suggested to be linked to the presence of heterogenous glycan contents on the Fab of the SP2/0-produced cetuximab.	Polysaccharides	190-196	FA complementation group B	Homo sapiens	213-216
34632911-2	2021	While effective, cetuximab is associated with a higher rate of skin rash, infusion reactions, and gastrointestinal toxicity, which was suggested to be linked to the presence of heterogenous glycan contents on the Fab of the SP2/0-produced cetuximab.	Polysaccharides	190-196	Sp2 transcription factor	Homo sapiens	224-229
34673030-5	2021	By designing a covalent disulfide bridge between protomers to control homodimer strength and stability, we demonstrate the importance of dimer interface perturbations on the allosteric network bridging the two opposite glycan binding sites on GAL-7, resulting in control of induced apoptosis in Jurkat T cells.	Polysaccharides	219-225	galectin 7	Homo sapiens	243-248
34632911-3	2021	OBJECTIVE AND METHODS: To improve efficacy and minimize toxicity of EGFR inhibition treatment, we re-engineered cetuximab by humanizing its Fab regions and minimizing its glycan contents to generate HLX07.	Polysaccharides	171-177	epidermal growth factor receptor	Homo sapiens	68-72
34600700-2	2021	In this study, self-assembly with the assistance of vortexing and pulsed-ultrasonication was employed to develop a Fibersol -2 (a digestion-resistant polysaccharide) and lipoid S75 based novel nanocarrier (denoted as nanofibersolosome) for the colonic delivery of cyanidin-3-O-glucoside (C3G).	Polysaccharides	150-164	Rap guanine nucleotide exchange factor 1	Homo sapiens	288-291
34191296-1	2021	Retraction: "Effects of astragalus polysaccharide on apoptosis of myocardial microvascular endothelial cells in rats undergoing hypoxia/reoxygenation by mediation of the PI3K/Akt/eNOS signaling pathway," by Qingling Zhou, Guowei Meng, Fei Teng, Qiang Sun, Yongshan Zhang, J Cell Biochem.	Polysaccharides	35-49	AKT serine/threonine kinase 1	Rattus norvegicus	175-178
34715561-0	2021	Targeting glycan sulfation in a CD11c+ myeloid population inhibits early KRAS-mutant lung neoplasia.	Polysaccharides	10-16	integrin subunit alpha X	Homo sapiens	32-37
34191296-1	2021	Retraction: "Effects of astragalus polysaccharide on apoptosis of myocardial microvascular endothelial cells in rats undergoing hypoxia/reoxygenation by mediation of the PI3K/Akt/eNOS signaling pathway," by Qingling Zhou, Guowei Meng, Fei Teng, Qiang Sun, Yongshan Zhang, J Cell Biochem.	Polysaccharides	35-49	nitric oxide synthase 3	Rattus norvegicus	179-183
34642951-1	2021	In this study, the digestion and fermentation properties of a bioactive polysaccharide (MOP-2) purified from Moringa oleifera leaves and its impact on the human colonic microbiota were determined using simulated saliva-gastrointestinal digestion and human fecal fermentation models in vitro.	Polysaccharides	72-86	endothelial PAS domain protein 1	Homo sapiens	88-93
34642951-10	2021	This work reported that a polysaccharide (MOP-2) purified from Moringa oleifera leaves could modulate the microbial structure by improving the relative abundances of some beneficial gut microbiota, which provided useful information for the application of MOP-2 as a prebiotic additive in food industry.	Polysaccharides	26-40	endothelial PAS domain protein 1	Homo sapiens	42-47
34642951-10	2021	This work reported that a polysaccharide (MOP-2) purified from Moringa oleifera leaves could modulate the microbial structure by improving the relative abundances of some beneficial gut microbiota, which provided useful information for the application of MOP-2 as a prebiotic additive in food industry.	Polysaccharides	26-40	endothelial PAS domain protein 1	Homo sapiens	255-260
34543843-3	2021	We demonstrate that the interaction between TAPBPR and MHC-I is stronger when MHC-I lacks a glycan.	Polysaccharides	92-98	TAP binding protein like	Homo sapiens	44-50
34543843-7	2021	The discovery that the glycan attached to MHC-I significantly influences the affinity of their interactions with TAPBPR has important implications, on both an experimental level and in a biological context.	Polysaccharides	23-29	TAP binding protein like	Homo sapiens	113-119
34715561-0	2021	Targeting glycan sulfation in a CD11c+ myeloid population inhibits early KRAS-mutant lung neoplasia.	Polysaccharides	10-16	KRAS proto-oncogene, GTPase	Homo sapiens	73-77
34715561-2	2021	We recently identified how a loss-of-function mutation in the glycan sulfating enzyme N-deacetylase/N-sulfotransferase-1 (Ndst1; involved in heparan sulfate biosynthesis) targeted to antigen presenting cells (APCs) may augment acquired anti-tumor T cell immune mechanisms.	Polysaccharides	62-68	N-deacetylase and N-sulfotransferase 1	Homo sapiens	86-120
34715561-2	2021	We recently identified how a loss-of-function mutation in the glycan sulfating enzyme N-deacetylase/N-sulfotransferase-1 (Ndst1; involved in heparan sulfate biosynthesis) targeted to antigen presenting cells (APCs) may augment acquired anti-tumor T cell immune mechanisms.	Polysaccharides	62-68	N-deacetylase and N-sulfotransferase 1	Homo sapiens	122-127
34715561-7	2021	The impact of this unique glycan under-sulfating mutation on inhibiting early Kras G12D mutant bronchocentric adenoma formation along with a cellular phenotype of inhibited tumor infiltration by cells involved in suppressive T-regulatory cell signaling (FOXP3+ cells) or tumor-permissive M2 macrophage functions (CD163+ cells) provides insight on how glycan targeting may modulate innate cellular mechanisms during early lung tumor development.	Polysaccharides	26-32	KRAS proto-oncogene, GTPase	Homo sapiens	78-82
34715561-7	2021	The impact of this unique glycan under-sulfating mutation on inhibiting early Kras G12D mutant bronchocentric adenoma formation along with a cellular phenotype of inhibited tumor infiltration by cells involved in suppressive T-regulatory cell signaling (FOXP3+ cells) or tumor-permissive M2 macrophage functions (CD163+ cells) provides insight on how glycan targeting may modulate innate cellular mechanisms during early lung tumor development.	Polysaccharides	351-357	forkhead box P3	Homo sapiens	254-259
34715561-7	2021	The impact of this unique glycan under-sulfating mutation on inhibiting early Kras G12D mutant bronchocentric adenoma formation along with a cellular phenotype of inhibited tumor infiltration by cells involved in suppressive T-regulatory cell signaling (FOXP3+ cells) or tumor-permissive M2 macrophage functions (CD163+ cells) provides insight on how glycan targeting may modulate innate cellular mechanisms during early lung tumor development.	Polysaccharides	351-357	CD163 molecule	Homo sapiens	313-318
34543669-6	2021	The expression of five glycan-related genes (alg2, gnsb, b4galt2, b3gat1a, and b3gat2) was significantly altered, with changes depending on the embryonic stage at exposure, with more severe deformities with exposure at earlier stages.	Polysaccharides	23-29	alpha-1,3/1,6-mannosyltransferase ALG2	Oryzias latipes	45-49
34543669-6	2021	The expression of five glycan-related genes (alg2, gnsb, b4galt2, b3gat1a, and b3gat2) was significantly altered, with changes depending on the embryonic stage at exposure, with more severe deformities with exposure at earlier stages.	Polysaccharides	23-29	beta-1,4-galactosyltransferase 2	Oryzias latipes	57-64
34543669-6	2021	The expression of five glycan-related genes (alg2, gnsb, b4galt2, b3gat1a, and b3gat2) was significantly altered, with changes depending on the embryonic stage at exposure, with more severe deformities with exposure at earlier stages.	Polysaccharides	23-29	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2	Oryzias latipes	79-85
34494876-16	2021	These findings offer insight into the glycan structure and function of ACE2 and potentially suggest that future antiviral therapies against coronaviruses and other coronavirus-related illnesses involving inhibition of ACE2 recruitment to the cell membrane could be developed.	Polysaccharides	38-44	angiotensin converting enzyme 2	Homo sapiens	71-75
34778211-11	2021	Furthermore, a decrease in fucosylation content was observed in FUT8KO cells, in which core-fucosylated glycans almost disappeared as an effect of FUT8 gene knockout.	Polysaccharides	104-111	alpha-(1,6)-fucosyltransferase	Cricetulus griseus	64-68
34778211-11	2021	Furthermore, a decrease in fucosylation content was observed in FUT8KO cells, in which core-fucosylated glycans almost disappeared as an effect of FUT8 gene knockout.	Polysaccharides	104-111	alpha-(1,6)-fucosyltransferase	Cricetulus griseus	147-151
34827585-0	2021	Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study.	Polysaccharides	0-6	CD209 molecule	Homo sapiens	55-62
34827585-2	2021	DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) is a protein expressed in antigen-presenting cells that recognizes a variety of glycan epitopes.	Polysaccharides	170-176	CD209 molecule	Homo sapiens	0-7
34827585-2	2021	DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) is a protein expressed in antigen-presenting cells that recognizes a variety of glycan epitopes.	Polysaccharides	170-176	CD209 molecule	Homo sapiens	9-88
34827585-9	2021	Based on our findings and previously described glycoforms on the SARS-CoV-2 Spike, we predicted the potential glycan epitopes for DC-SIGN.	Polysaccharides	110-116	CD209 molecule	Homo sapiens	130-137
34939081-3	2022	The excellent diagnostic performance of this glycan biomarker in blood plasma N-glycans of individuals with HNF1A-MODY has been demonstrated using liquid chromatography methods.	Polysaccharides	45-51	HNF1 homeobox A	Homo sapiens	108-113
34776961-2	2021	The polysaccharide fraction of P. kingianum can reduce insulin resistance and restore the gut microbiota in a rat model of aberrant lipid metabolism by down regulating miR-122.	Polysaccharides	4-18	microRNA 122	Rattus norvegicus	168-175
34829559-1	2021	To investigate the structure of Arthrospira platensis polysaccharide (PAP) (intracellular polysaccharide) and the antioxidant activity of the first component of PAP (PAP-1) on pseudorabies virus (PRV) -infected RAW264.7 cells.	Polysaccharides	90-104	regenerating islet-derived 3 beta	Mus musculus	70-73
34828846-3	2021	Cereal DF is an umbrella concept of heterogeneous polysaccharides of variable chemical composition and molecular weight, which are combined in a complex network in cereal cell walls.	Polysaccharides	50-65	complement factor D	Homo sapiens	7-9
34666001-6	2021	Our data support that Wsc1 accumulates to sites of enhanced mechanical stress through reduced lateral diffusivity, mediated by the binding of its extracellular WSC domain to CW polysaccharides, independent of canonical polarity, trafficking, and downstream CW regulatory pathways.	Polysaccharides	177-192	Slg1p	Saccharomyces cerevisiae S288C	22-26
34688604-0	2022	Identification of beta1-3 galactosylglucose-core free-glycans in human urine.	Polysaccharides	54-61	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	18-25
34832856-6	2021	The normalization of the level of the pro-inflammatory cytokine IL-6 in the serum and the recovery of cell populations in the spleen were observed in immunosuppressed mice following treatment with the polysaccharides.	Polysaccharides	201-216	interleukin 6	Mus musculus	64-68
34832856-7	2021	An increase in the proliferative activity of hematopoietic cells CD34(+)CD45(+) was observed following ex vivo polysaccharide exposure.	Polysaccharides	111-125	CD34 antigen	Mus musculus	65-69
34832856-7	2021	An increase in the proliferative activity of hematopoietic cells CD34(+)CD45(+) was observed following ex vivo polysaccharide exposure.	Polysaccharides	111-125	protein tyrosine phosphatase, receptor type, C	Mus musculus	72-76
34519773-1	2021	We found that ascophyllan significantly inhibited the fibrillation of human insulin, and was the most effective among the sulfated polysaccharides tested.	Polysaccharides	131-146	insulin	Homo sapiens	76-83
34688604-8	2022	Although glycans with a beta1-3 galactosylglucose-core were identified as major components in urine, comprising structurally simple isomers of a lactose-core, the core structure has not previously been reported.	Polysaccharides	9-16	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	24-31
34688604-9	2022	The major beta1-3 galactosylglucose-core glycans were Fucalpha1-2Galbeta1-3(Fucalpha1-4)Glc, GalNAcalpha1-3(Fucalpha1-2)Galbeta1-3(Fucalpha1-4)Glc and Galalpha1-3(Fucalpha1-2)Galbeta1-3(Fucalpha1-4)Glc, corresponding to H-, A-, and B-blood group antigens, respectively.	Polysaccharides	41-48	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	10-17
34688604-9	2022	The major beta1-3 galactosylglucose-core glycans were Fucalpha1-2Galbeta1-3(Fucalpha1-4)Glc, GalNAcalpha1-3(Fucalpha1-2)Galbeta1-3(Fucalpha1-4)Glc and Galalpha1-3(Fucalpha1-2)Galbeta1-3(Fucalpha1-4)Glc, corresponding to H-, A-, and B-blood group antigens, respectively.	Polysaccharides	41-48	alpha-L-fucosidase 1	Homo sapiens	76-87
34688604-9	2022	The major beta1-3 galactosylglucose-core glycans were Fucalpha1-2Galbeta1-3(Fucalpha1-4)Glc, GalNAcalpha1-3(Fucalpha1-2)Galbeta1-3(Fucalpha1-4)Glc and Galalpha1-3(Fucalpha1-2)Galbeta1-3(Fucalpha1-4)Glc, corresponding to H-, A-, and B-blood group antigens, respectively.	Polysaccharides	41-48	alpha-L-fucosidase 1	Homo sapiens	93-119
34688604-9	2022	The major beta1-3 galactosylglucose-core glycans were Fucalpha1-2Galbeta1-3(Fucalpha1-4)Glc, GalNAcalpha1-3(Fucalpha1-2)Galbeta1-3(Fucalpha1-4)Glc and Galalpha1-3(Fucalpha1-2)Galbeta1-3(Fucalpha1-4)Glc, corresponding to H-, A-, and B-blood group antigens, respectively.	Polysaccharides	41-48	alpha-L-fucosidase 1	Homo sapiens	163-174
34688604-9	2022	The major beta1-3 galactosylglucose-core glycans were Fucalpha1-2Galbeta1-3(Fucalpha1-4)Glc, GalNAcalpha1-3(Fucalpha1-2)Galbeta1-3(Fucalpha1-4)Glc and Galalpha1-3(Fucalpha1-2)Galbeta1-3(Fucalpha1-4)Glc, corresponding to H-, A-, and B-blood group antigens, respectively.	Polysaccharides	41-48	alpha-L-fucosidase 1	Homo sapiens	186-197
34688604-11	2022	Elucidating the biosynthesis of beta1-3 galactosylglucose will be crucial for understanding the in vivo function of these glycans.	Polysaccharides	122-129	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	32-39
34745128-6	2021	Finally, eighteen N-glycosites and five O-glycosites with attached glycans were assigned unambiguously from heavily glycosylated gp120.	Polysaccharides	67-74	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	129-134
34755670-2	2021	METHODS: Three polysaccharides with different molecular masses, namely RPS-1, RPS-2 and RPS-3, were separated from the fermentation broth of Rhizopus nigricans by fractional ethanol precipitation, and their capacity for scavenging DPPH, ABTS, and hydroxyl radicals was assessed.	Polysaccharides	15-30	ribosomal protein S2	Mus musculus	78-83
34768798-3	2021	Raman spectra revealed that salt-exposed alpha-TC accumulating plants were more flexible in regulating chlorophyll, carotenoid and polysaccharide levels than TC deficient mutants, while the plants overaccumulating gamma-TC had the lowest levels of these biocompounds.	Polysaccharides	131-145	centroradiali	Arabidopsis thaliana	41-49
34755670-2	2021	METHODS: Three polysaccharides with different molecular masses, namely RPS-1, RPS-2 and RPS-3, were separated from the fermentation broth of Rhizopus nigricans by fractional ethanol precipitation, and their capacity for scavenging DPPH, ABTS, and hydroxyl radicals was assessed.	Polysaccharides	15-30	ribosomal protein S3	Mus musculus	88-93
34755670-8	2021	CONCLUSION: The 3 polysaccharides all have antioxidant, anti-tumor and immunomodulatory activities, and among them RPS-1 and RPS-3 have better antioxidant activities, and RPS-2 has stronger anti-tumor and immunomodulatory activities.	Polysaccharides	18-33	ribosomal protein S3	Mus musculus	125-130
34755670-8	2021	CONCLUSION: The 3 polysaccharides all have antioxidant, anti-tumor and immunomodulatory activities, and among them RPS-1 and RPS-3 have better antioxidant activities, and RPS-2 has stronger anti-tumor and immunomodulatory activities.	Polysaccharides	18-33	ribosomal protein S2	Mus musculus	171-176
34939101-4	2022	Mucin glycan degradation is a complex process that requires a broad range of glycan degrading enzymes, as mucin glycans are intricate and diverse molecules.	Polysaccharides	77-83	LOC100508689	Homo sapiens	0-5
34834161-9	2021	These findings suggest that Fab N-glycosites have higher accessibility to enzymes responsible for glycan maturation.	Polysaccharides	98-104	FA complementation group B	Homo sapiens	28-31
34939101-4	2022	Mucin glycan degradation is a complex process that requires a broad range of glycan degrading enzymes, as mucin glycans are intricate and diverse molecules.	Polysaccharides	77-83	LOC100508689	Homo sapiens	106-111
34181849-0	2021	Proximity Tagging Identifies the Glycan-Mediated Glycoprotein Interactors of Galectin-1 in Muscle Stem Cells.	Polysaccharides	33-39	lectin, galactose binding, soluble 1	Mus musculus	77-87
34679128-11	2021	In contrast, sequon optimization and inserting/removing glycans at other positions frequently had global "ripple" effects on glycan maturation and sequon occupation throughout the gp120 outer domain and gp41.	Polysaccharides	56-63	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	180-185
34181849-2	2021	The glycan-binding protein galectin-1 has been found to be a potent activator of myogenic differentiation.	Polysaccharides	4-10	lectin, galactose binding, soluble 1	Mus musculus	27-37
34181849-8	2021	Indeed, we identify several known and novel glycan-mediated ligands of galectin-1 as well as validate that galectin-1 binds the native CD44 glycoprotein in a glycan-mediated manner.	Polysaccharides	44-50	lectin, galactose binding, soluble 1	Mus musculus	71-81
34181849-8	2021	Indeed, we identify several known and novel glycan-mediated ligands of galectin-1 as well as validate that galectin-1 binds the native CD44 glycoprotein in a glycan-mediated manner.	Polysaccharides	44-50	CD44 antigen	Mus musculus	135-139
34181849-8	2021	Indeed, we identify several known and novel glycan-mediated ligands of galectin-1 as well as validate that galectin-1 binds the native CD44 glycoprotein in a glycan-mediated manner.	Polysaccharides	158-164	lectin, galactose binding, soluble 1	Mus musculus	71-81
34478702-3	2021	Here, we develop a new strategy for the analysis of lyso-GSL (l-GSL), GSL that retain linkage of the glycan headgroup with the Sph base.	Polysaccharides	101-107	cathepsin A	Homo sapiens	70-73
34181849-8	2021	Indeed, we identify several known and novel glycan-mediated ligands of galectin-1 as well as validate that galectin-1 binds the native CD44 glycoprotein in a glycan-mediated manner.	Polysaccharides	158-164	lectin, galactose binding, soluble 1	Mus musculus	107-117
34181849-8	2021	Indeed, we identify several known and novel glycan-mediated ligands of galectin-1 as well as validate that galectin-1 binds the native CD44 glycoprotein in a glycan-mediated manner.	Polysaccharides	158-164	CD44 antigen	Mus musculus	135-139
34529436-5	2021	Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding.	Polysaccharides	18-24	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	47-48
34703312-7	2021	The results show that MUC2 is a highly glycosylated protein, with glycan accounts for 80% to 90% of the dry weight.	Polysaccharides	66-72	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	22-26
34754374-3	2021	In view of all this, we were intrigued to explore galectin-3 (Gal-3) as a glycan, and in our previous study, we measured its elevated levels in remission of schizophrenia.	Polysaccharides	74-80	galectin 3	Homo sapiens	50-60
34754374-3	2021	In view of all this, we were intrigued to explore galectin-3 (Gal-3) as a glycan, and in our previous study, we measured its elevated levels in remission of schizophrenia.	Polysaccharides	74-80	galectin 3	Homo sapiens	62-67
34648519-1	2021	Fucosyltransferase 2 (FUT2) catalyzes the biosynthesis of A, B, and H antigens and other important glycans, such as (Sialyl Lewisx) sLex, and (Sialyl Lewisy) sLey.	Polysaccharides	99-106	fucosyltransferase 2	Homo sapiens	0-20
34648519-1	2021	Fucosyltransferase 2 (FUT2) catalyzes the biosynthesis of A, B, and H antigens and other important glycans, such as (Sialyl Lewisx) sLex, and (Sialyl Lewisy) sLey.	Polysaccharides	99-106	fucosyltransferase 2	Homo sapiens	22-26
34648519-2	2021	The production of these glycans is increased in various cancers, hence to design and develop specific inhibitors of FUT2 is a therapeutic strategy.	Polysaccharides	24-31	fucosyltransferase 2	Homo sapiens	116-120
34703264-6	2021	One polysaccharide was selected to detect oxidative damage markers and gene expression in the Keap1-Nrf2/ARE signaling pathway in HSFs.	Polysaccharides	4-18	kelch like ECH associated protein 1	Homo sapiens	94-99
34703264-6	2021	One polysaccharide was selected to detect oxidative damage markers and gene expression in the Keap1-Nrf2/ARE signaling pathway in HSFs.	Polysaccharides	4-18	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
34529436-5	2021	Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding.	Polysaccharides	18-24	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	58-59
34529436-5	2021	Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding.	Polysaccharides	18-24	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	109-110
34529436-5	2021	Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding.	Polysaccharides	98-105	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	47-48
34529436-5	2021	Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding.	Polysaccharides	98-105	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	58-59
34529436-5	2021	Comparison of the glycan conformations between S-only and S-antibody systems reveals the roles of glycans in S-antibody binding.	Polysaccharides	98-105	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	109-110
34690972-5	2021	In this study, we defined the binding specificity of galectin-3 (Gal-3), the first galectin shown to engage microbial glycans.	Polysaccharides	118-125	galectin 3	Homo sapiens	53-63
34255834-4	2021	Previously, we reported that FKTN and FKRP can also transfer glycerol phosphate (GroP) from CDP-glycerol (CDP-Gro) and showed the inhibitory effects of CDP-Gro on functional glycan synthesis by preventing glycan elongation in vitro.	Polysaccharides	174-180	fukutin	Homo sapiens	29-33
34255834-4	2021	Previously, we reported that FKTN and FKRP can also transfer glycerol phosphate (GroP) from CDP-glycerol (CDP-Gro) and showed the inhibitory effects of CDP-Gro on functional glycan synthesis by preventing glycan elongation in vitro.	Polysaccharides	174-180	fukutin related protein	Homo sapiens	38-42
34255834-4	2021	Previously, we reported that FKTN and FKRP can also transfer glycerol phosphate (GroP) from CDP-glycerol (CDP-Gro) and showed the inhibitory effects of CDP-Gro on functional glycan synthesis by preventing glycan elongation in vitro.	Polysaccharides	174-180	natriuretic peptide A	Homo sapiens	152-155
34255834-4	2021	Previously, we reported that FKTN and FKRP can also transfer glycerol phosphate (GroP) from CDP-glycerol (CDP-Gro) and showed the inhibitory effects of CDP-Gro on functional glycan synthesis by preventing glycan elongation in vitro.	Polysaccharides	174-180	chemokine (C-X-C motif) ligand 1	Mus musculus	156-159
34255834-4	2021	Previously, we reported that FKTN and FKRP can also transfer glycerol phosphate (GroP) from CDP-glycerol (CDP-Gro) and showed the inhibitory effects of CDP-Gro on functional glycan synthesis by preventing glycan elongation in vitro.	Polysaccharides	205-211	fukutin	Homo sapiens	29-33
34255834-4	2021	Previously, we reported that FKTN and FKRP can also transfer glycerol phosphate (GroP) from CDP-glycerol (CDP-Gro) and showed the inhibitory effects of CDP-Gro on functional glycan synthesis by preventing glycan elongation in vitro.	Polysaccharides	205-211	fukutin related protein	Homo sapiens	38-42
34255834-4	2021	Previously, we reported that FKTN and FKRP can also transfer glycerol phosphate (GroP) from CDP-glycerol (CDP-Gro) and showed the inhibitory effects of CDP-Gro on functional glycan synthesis by preventing glycan elongation in vitro.	Polysaccharides	205-211	natriuretic peptide A	Homo sapiens	152-155
34255834-4	2021	Previously, we reported that FKTN and FKRP can also transfer glycerol phosphate (GroP) from CDP-glycerol (CDP-Gro) and showed the inhibitory effects of CDP-Gro on functional glycan synthesis by preventing glycan elongation in vitro.	Polysaccharides	205-211	chemokine (C-X-C motif) ligand 1	Mus musculus	156-159
34690972-8	2021	Similar to the recognition of mammalian glycans, Gal-3 and Gal-3C also specifically engaged distinct microbial glycans isolated and printed in a microarray format, with Gal-3 exhibiting higher binding at lower concentrations toward microbial glycans than Gal-3C.	Polysaccharides	242-249	galectin 3	Homo sapiens	49-54
34690972-8	2021	Similar to the recognition of mammalian glycans, Gal-3 and Gal-3C also specifically engaged distinct microbial glycans isolated and printed in a microarray format, with Gal-3 exhibiting higher binding at lower concentrations toward microbial glycans than Gal-3C.	Polysaccharides	242-249	galectin 3	Homo sapiens	59-65
34690972-8	2021	Similar to the recognition of mammalian glycans, Gal-3 and Gal-3C also specifically engaged distinct microbial glycans isolated and printed in a microarray format, with Gal-3 exhibiting higher binding at lower concentrations toward microbial glycans than Gal-3C.	Polysaccharides	242-249	galectin 3	Homo sapiens	169-174
34690972-11	2021	These results demonstrate that while Gal-3 and Gal-3C specifically engage distinct mammalian and microbial glycans, Gal-3C alone does not possess antimicrobial activity.	Polysaccharides	107-114	galectin 3	Homo sapiens	37-42
34690972-11	2021	These results demonstrate that while Gal-3 and Gal-3C specifically engage distinct mammalian and microbial glycans, Gal-3C alone does not possess antimicrobial activity.	Polysaccharides	107-114	galectin 3	Homo sapiens	47-53
34517042-0	2021	Increasing phagocytosis of micoglia by targeting CD33 with liposomes displaying glycan ligands.	Polysaccharides	80-86	CD33 molecule	Homo sapiens	49-53
34517042-2	2021	While antibodies targeting CD33 have entered clinical trials to treat neurodegeneration, it is unknown whether the glycan-binding properties of CD33 can be exploited to modulate microglia.	Polysaccharides	115-121	CD33 molecule	Homo sapiens	144-148
34517042-3	2021	Here, we use liposomes that multivalently display glycan ligands of CD33 (CD33L liposomes) to engage CD33.	Polysaccharides	50-56	CD33 molecule	Homo sapiens	68-72
34517042-3	2021	Here, we use liposomes that multivalently display glycan ligands of CD33 (CD33L liposomes) to engage CD33.	Polysaccharides	50-56	sialic acid binding Ig like lectin 6	Homo sapiens	74-79
34517042-3	2021	Here, we use liposomes that multivalently display glycan ligands of CD33 (CD33L liposomes) to engage CD33.	Polysaccharides	50-56	CD33 molecule	Homo sapiens	101-105
34517042-6	2021	Increased phagocytosis by treatment with CD33L liposomes is dependent on a key intracellular signaling motif on CD33 as well as the glycan-binding ability of CD33.	Polysaccharides	132-138	sialic acid binding Ig like lectin 6	Homo sapiens	41-46
34517042-6	2021	Increased phagocytosis by treatment with CD33L liposomes is dependent on a key intracellular signaling motif on CD33 as well as the glycan-binding ability of CD33.	Polysaccharides	132-138	CD33 molecule	Homo sapiens	158-162
34517042-9	2021	These results demonstrate that multivalent engagement of CD33 with glycan ligands can modulate microglial cell function.	Polysaccharides	67-73	CD33 molecule	Homo sapiens	57-61
34690972-5	2021	In this study, we defined the binding specificity of galectin-3 (Gal-3), the first galectin shown to engage microbial glycans.	Polysaccharides	118-125	galectin 3	Homo sapiens	65-70
34690972-6	2021	Gal-3 exhibited high binding toward mammalian blood group A, B, and alphaGal antigens in a glycan microarray format.	Polysaccharides	91-97	galectin 3	Homo sapiens	0-5
34690972-8	2021	Similar to the recognition of mammalian glycans, Gal-3 and Gal-3C also specifically engaged distinct microbial glycans isolated and printed in a microarray format, with Gal-3 exhibiting higher binding at lower concentrations toward microbial glycans than Gal-3C.	Polysaccharides	40-47	galectin 3	Homo sapiens	49-54
34690972-8	2021	Similar to the recognition of mammalian glycans, Gal-3 and Gal-3C also specifically engaged distinct microbial glycans isolated and printed in a microarray format, with Gal-3 exhibiting higher binding at lower concentrations toward microbial glycans than Gal-3C.	Polysaccharides	40-47	galectin 3	Homo sapiens	59-65
34690972-8	2021	Similar to the recognition of mammalian glycans, Gal-3 and Gal-3C also specifically engaged distinct microbial glycans isolated and printed in a microarray format, with Gal-3 exhibiting higher binding at lower concentrations toward microbial glycans than Gal-3C.	Polysaccharides	40-47	galectin 3	Homo sapiens	169-174
34690972-8	2021	Similar to the recognition of mammalian glycans, Gal-3 and Gal-3C also specifically engaged distinct microbial glycans isolated and printed in a microarray format, with Gal-3 exhibiting higher binding at lower concentrations toward microbial glycans than Gal-3C.	Polysaccharides	111-118	galectin 3	Homo sapiens	49-54
34690972-8	2021	Similar to the recognition of mammalian glycans, Gal-3 and Gal-3C also specifically engaged distinct microbial glycans isolated and printed in a microarray format, with Gal-3 exhibiting higher binding at lower concentrations toward microbial glycans than Gal-3C.	Polysaccharides	111-118	galectin 3	Homo sapiens	59-65
34611829-0	2022	Polysaccharide Krestin Prevents Alzheimer"s Disease-type Pathology and Cognitive Deficits by Enhancing Monocyte Amyloid-beta Processing.	Polysaccharides	0-14	amyloid beta precursor protein	Homo sapiens	112-124
34690938-4	2021	However, the GH involved in glycan breakdown (adhesion, hydrolysis, and fermentation) are organized in polysaccharide utilization loci (PUL) with complex modularity.	Polysaccharides	28-34	gamma-glutamyl hydrolase	Homo sapiens	13-15
34690938-4	2021	However, the GH involved in glycan breakdown (adhesion, hydrolysis, and fermentation) are organized in polysaccharide utilization loci (PUL) with complex modularity.	Polysaccharides	103-117	gamma-glutamyl hydrolase	Homo sapiens	13-15
34375000-6	2021	3D modelling showed that both lectins can bind to a glycan within the RBD-ACE2 interface and thus interferes with Spike binding to cell surfaces.	Polysaccharides	52-58	angiotensin converting enzyme 2	Homo sapiens	74-78
34608922-0	2021	A novel polysaccharide obtained from Siraitia grosvenorii alleviates inflammatory responses in a diabetic nephropathy mouse model via the TLR4-NF-kappaB pathway.	Polysaccharides	8-22	toll-like receptor 4	Mus musculus	138-142
34608922-0	2021	A novel polysaccharide obtained from Siraitia grosvenorii alleviates inflammatory responses in a diabetic nephropathy mouse model via the TLR4-NF-kappaB pathway.	Polysaccharides	8-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-152
34385100-4	2021	In addition, the inhibition and repolarization effect of digested Codonopsis pilosula polysaccharide (dCPP) on the proliferation of tumor-associated macrophages (TAMs) with M2-like phenotype induced by IL-4 were investigated.	Polysaccharides	86-100	interleukin 4	Mus musculus	202-206
34294336-1	2021	Curdlan is a bacterial sourced polysaccharide, consisting of a linear backbone of beta-1   3-linked glucose (Glc) units.	Polysaccharides	31-45	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	82-92
34611296-8	2022	These results reveal a central contribution of LOX-1 to EC development and provide genetic ablation or bioactive polysaccharide as an effective intervention for EC therapy.	Polysaccharides	113-127	oxidized low density lipoprotein receptor 1	Homo sapiens	47-52
34538334-8	2021	The variable domains of Ig heavy chains were downregulated and the overall glycosylation of IgA heavy chain constant regions, IgGFc-binding protein, and J chain were suppressed with glycan-specific variations.	Polysaccharides	182-188	Fc gamma binding protein	Homo sapiens	126-147
34375000-6	2021	3D modelling showed that both lectins can bind to a glycan within the RBD-ACE2 interface and thus interferes with Spike binding to cell surfaces.	Polysaccharides	52-58	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	114-119
34358595-6	2021	Furthermore, a novel polysaccharide, namely, BAPF, was purified from BAP by using DEAE Cellulose-52 column and Sephadex G-100 gel column.	Polysaccharides	21-35	prohibitin 2	Mus musculus	69-72
34658894-0	2021	Achyranthes bidentata Polysaccharide Activates Nuclear Factor-Kappa B and Promotes Cytokine Production in J774A.1 Cells Through TLR4/MyD88 Signaling Pathway.	Polysaccharides	22-36	toll-like receptor 4	Mus musculus	128-132
34658894-0	2021	Achyranthes bidentata Polysaccharide Activates Nuclear Factor-Kappa B and Promotes Cytokine Production in J774A.1 Cells Through TLR4/MyD88 Signaling Pathway.	Polysaccharides	22-36	myeloid differentiation primary response gene 88	Mus musculus	133-138
34596313-0	2021	Mac-2 binding protein and its glycan isomer: Where does it come from?	Polysaccharides	30-36	galectin 3 binding protein	Homo sapiens	0-21
34358595-1	2021	A polysaccharide from the aqueous extract of Boletus aereus fruit (BAP) was isolated.	Polysaccharides	2-16	prohibitin 2	Mus musculus	67-70
34480673-9	2021	Thirty five kinds of O-glycans were identified, most of which were Core 3-derived glycans.	Polysaccharides	82-89	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 (core 3 synthase)	Mus musculus	67-73
34132435-8	2021	Thus, upon lectin-glycan binding on the cell surface, our results suggest that VGL induces an acute inflammatory response, in turn activating the release of peritoneal macrophages via TNF-alpha and TLR and/or TNFR receptor pathways.	Polysaccharides	18-24	tumor necrosis factor	Rattus norvegicus	184-193
34358563-3	2021	Unlike other PLs, Smlt1473 present in the clinically-relevant Stenotrophomonas maltophilia strain K279a demonstrates a wide range of pH-dependent substrate specificities towards multiple, diverse polysaccharides: hyaluronic acid (pH 5.0), poly-beta-D-glucuronic (celluronic) acid (pH 7.0), poly-beta-D-mannuronic acid, and poly-alpha-L-guluronate (pH 9.0).	Polysaccharides	196-211	polysaccharide lyase	Stenotrophomonas maltophilia K279a	18-26
34413500-0	2021	A glycan gate controls opening of the SARS-CoV-2 spike protein.	Polysaccharides	2-8	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	49-54
34413500-1	2021	SARS-CoV-2 infection is controlled by the opening of the spike protein receptor binding domain (RBD), which transitions from a glycan-shielded "down" to an exposed "up" state to bind the human angiotensin-converting enzyme 2 receptor and infect cells.	Polysaccharides	127-133	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	57-62
34659153-1	2021	HIV envelope glycoprotein is the most heavily glycosylated viral protein complex identified with over 20 glycans on its surface.	Polysaccharides	105-112	endogenous retrovirus group K member 20	Homo sapiens	4-25
34486386-1	2021	Chitosan is a polysaccharide made up of beta1,4-linked D-glucosamine (GlcN) and N-acetyl-GlcN.	Polysaccharides	14-28	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	40-45
34738405-0	2021	(Antidepressant effect of acidic polysaccharides from Poria and their regulation of neurotransmitters and NLRP3 pathway).	Polysaccharides	33-48	NLR family, pyrin domain containing 3	Rattus norvegicus	106-111
34738405-5	2021	The results showed that compared with the model group, acidic polysaccharides from Poria at the low-, medium-, and high-doses(0.1, 0.3 and 0.5 g kg~(-1) d~(-1)) all improved the depression-like behavior of rats, increased the number of neurons and the levels of BDNF, 5-HT, 5-HIAA, DA, and NE in the hippocampus, and reduced GLU and serum IL-1beta, IL-18, and TNF-alpha levels.	Polysaccharides	62-77	brain-derived neurotrophic factor	Rattus norvegicus	262-266
34738405-5	2021	The results showed that compared with the model group, acidic polysaccharides from Poria at the low-, medium-, and high-doses(0.1, 0.3 and 0.5 g kg~(-1) d~(-1)) all improved the depression-like behavior of rats, increased the number of neurons and the levels of BDNF, 5-HT, 5-HIAA, DA, and NE in the hippocampus, and reduced GLU and serum IL-1beta, IL-18, and TNF-alpha levels.	Polysaccharides	62-77	interleukin 1 alpha	Rattus norvegicus	339-347
34738405-5	2021	The results showed that compared with the model group, acidic polysaccharides from Poria at the low-, medium-, and high-doses(0.1, 0.3 and 0.5 g kg~(-1) d~(-1)) all improved the depression-like behavior of rats, increased the number of neurons and the levels of BDNF, 5-HT, 5-HIAA, DA, and NE in the hippocampus, and reduced GLU and serum IL-1beta, IL-18, and TNF-alpha levels.	Polysaccharides	62-77	interleukin 18	Rattus norvegicus	349-354
34738405-5	2021	The results showed that compared with the model group, acidic polysaccharides from Poria at the low-, medium-, and high-doses(0.1, 0.3 and 0.5 g kg~(-1) d~(-1)) all improved the depression-like behavior of rats, increased the number of neurons and the levels of BDNF, 5-HT, 5-HIAA, DA, and NE in the hippocampus, and reduced GLU and serum IL-1beta, IL-18, and TNF-alpha levels.	Polysaccharides	62-77	tumor necrosis factor	Rattus norvegicus	360-369
34738405-7	2021	All these have indicated that acidic polysaccharides from Poria exerted the antidepressant effect possibly by regulating neurotransmitters and NLRP3 inflammasome signaling pathway.	Polysaccharides	37-52	NLR family, pyrin domain containing 3	Rattus norvegicus	143-148
34457057-0	2021	Characterization of tumor-associated MUC1 and its glycans expressed in mucoepidermoid carcinoma.	Polysaccharides	50-57	mucin 1, cell surface associated	Homo sapiens	37-41
34457057-8	2021	MUC1 was found in MEC but not in NSGs, and almost all glycans of MUC1 in MEC were sialylated, whereas the glycans of mucins in NSGs were less sialylated.	Polysaccharides	54-61	mucin 1, cell surface associated	Homo sapiens	65-69
34457057-9	2021	The core 2 type glycans, (Hex)2(HexNAc)2(NeuAc)1 and (Hex)2(HexNAc)2(NeuAc)2, were found to be significantly abundant glycans of MUC1 in MEC.	Polysaccharides	16-23	mucin 1, cell surface associated	Homo sapiens	129-133
34457057-9	2021	The core 2 type glycans, (Hex)2(HexNAc)2(NeuAc)1 and (Hex)2(HexNAc)2(NeuAc)2, were found to be significantly abundant glycans of MUC1 in MEC.	Polysaccharides	118-125	mucin 1, cell surface associated	Homo sapiens	129-133
34457057-10	2021	MEC markedly produced MUC1 modified with sialylated core 2 glycans.	Polysaccharides	59-66	mucin 1, cell surface associated	Homo sapiens	22-26
34298044-3	2021	Commercially available amylose matrix for the affinity purification of MBP fusion proteins has two main issues: (i) low (micromolar) affinity and (ii) the limited number of uses due to the cleavage of polysaccharide matrix by the amylases, present in the crude cell extract.	Polysaccharides	201-215	myelin basic protein	Homo sapiens	71-74
34659153-4	2021	Recently, we showed that HIV envelope glycan binds to L-selectin in solution and on CD4 T lymphocytes.	Polysaccharides	38-44	selectin L	Homo sapiens	54-64
34659153-4	2021	Recently, we showed that HIV envelope glycan binds to L-selectin in solution and on CD4 T lymphocytes.	Polysaccharides	38-44	CD4 molecule	Homo sapiens	84-87
34659153-5	2021	The viral glycan and L-selectin interaction functions to facilitate the viral adhesion and entry.	Polysaccharides	10-16	selectin L	Homo sapiens	21-31
34646995-7	2021	These results highlight the importance of glycans in regulating ITGA2 stability and ligand binding capacity which in turn modulates downstream focal adhesion and promotes cell survival in a collagen environment.	Polysaccharides	42-49	integrin subunit alpha 2	Homo sapiens	64-69
34580715-2	2022	It is known that NGLY1 is involved in the degradation of cytosolic glycans (non-lysosomal glycan degradation) as well as ER-associated degradation (ERAD), a quality control system for newly synthesized glycoproteins.	Polysaccharides	67-74	N-glycanase 1	Homo sapiens	17-22
34580715-2	2022	It is known that NGLY1 is involved in the degradation of cytosolic glycans (non-lysosomal glycan degradation) as well as ER-associated degradation (ERAD), a quality control system for newly synthesized glycoproteins.	Polysaccharides	90-96	N-glycanase 1	Homo sapiens	17-22
34581784-4	2022	Furthermore, we find that this modification is not affected by loss of Galgt2, a glycotransferase which catalyzes the CT2 glycan.	Polysaccharides	122-128	cardiotrophin 2	Mus musculus	118-121
34677445-1	2021	Sugar-based molecules such as heparins or natural heparan sulfate polysaccharides have been developed and widely studied for controlling heparanase (HPSE) enzymatic activity, a key player in extracellular matrix remodelling during cancer pathogenesis.	Polysaccharides	66-81	heparanase	Homo sapiens	149-153
34559854-3	2021	Viral Env glycans, though host derived, are distinctly processed and thereby recognized or accommodated during antibody responses.	Polysaccharides	10-17	endogenous retrovirus group K member 20	Homo sapiens	6-9
34631661-11	2021	The relatively higher amount of high-mannose abundant sites (N17, N234, N343, N616, N709, N717, N801, and N1134) on HEK-Spike suggests that glycan-shielding may differ among the two constructs.	Polysaccharides	140-146	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	120-125
34735575-1	2022	Extensive glycosylation of the spike protein of severe acute respiratory syndrome coronavirus 2 virus not only shields the major part of it from host immune responses, but glycans at specific sites also act on its conformation dynamics and contribute to efficient host receptor binding, and hence infectivity.	Polysaccharides	172-179	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	31-36
34576124-6	2021	An ex vivo cell rolling assay revealed that sLex glycans mediate the rolling of mouse eosinophils on P-selectin-expressing cells.	Polysaccharides	49-56	selectin, platelet	Mus musculus	101-111
34681302-3	2021	This study aimed to investigate the anti-obesity and gut microbiota modulatory effect of crude polysaccharides separated from Se-rich C. militaris on a high-fat diet (HFD)-fed C57BL/6J mice model.	Polysaccharides	95-110	histocompatibility 40	Mus musculus	152-156
34584952-3	2021	Here, we report that sialic acid-containing glycans on the surface of both T cells and APCs are alternative ligands of CD28 that compete with binding to its well-documented activatory ligand CD80 on the APC, resulting in attenuated costimulation.	Polysaccharides	44-51	CD28 molecule	Homo sapiens	119-123
34584952-3	2021	Here, we report that sialic acid-containing glycans on the surface of both T cells and APCs are alternative ligands of CD28 that compete with binding to its well-documented activatory ligand CD80 on the APC, resulting in attenuated costimulation.	Polysaccharides	44-51	CD80 molecule	Homo sapiens	191-195
34343291-0	2021	Effects of changes in glycan composition on glycoprotein dynamics: example of N-glycans on insulin receptor.	Polysaccharides	22-28	insulin receptor	Homo sapiens	91-107
34343291-10	2021	Our observations will further aid in understanding the role of sugars in maintaining homeostasis and how changes in glycan composition may lead to perturbations in homeostasis, ultimately leading to conditions such as insulin resistance.	Polysaccharides	116-122	insulin	Homo sapiens	218-225
34544457-0	2021	A cancer-unique glycan: de-N-acetyl polysialic acid (dPSA) linked to cell surface nucleolin depends on re-expression of the fetal polysialyltransferase ST8SIA2 gene.	Polysaccharides	16-22	nucleolin	Homo sapiens	82-91
34127216-8	2021	Collectively, SHPS-1 polysaccharide from P. baumii had anti-inflammatory activity and can potentially treat IBD.	Polysaccharides	21-35	signal-regulatory protein alpha	Mus musculus	14-20
34576978-1	2021	Mucin-type O-glycosylation involves the attachment of glycans to an initial O-linked N-acetylgalactosamine (GalNAc) on serine and threonine residues on proteins.	Polysaccharides	54-61	LOC100508689	Homo sapiens	0-5
34525907-3	2022	Modifica-tions of the glycan backbone are limited to the C-2 amine and the C-6 hydroxyl moieties of either Glc-NAc or MurNAc residues.	Polysaccharides	22-28	synuclein alpha	Homo sapiens	111-114
34432454-0	2021	Noni (Morinda citrifolia L.) Fruit Polysaccharides Regulated IBD Mice Via Targeting Gut Microbiota: Association of JNK/ERK/NF-kappaB Signaling Pathways.	Polysaccharides	35-50	mitogen-activated protein kinase 8	Mus musculus	115-118
34564432-2	2021	Aim of this study is to explore glycan-biomarkers on transferrin (Tf) for Alzheimer"s disease (AD) in cerebrospinal fluid (CSF).	Polysaccharides	32-38	transferrin	Homo sapiens	53-64
34504130-0	2021	Glycosylation reduces the glycan-independent immunomodulatory effect of recombinant Orysata lectin in Drosophila S2 cells.	Polysaccharides	26-32	lectin-37Db	Drosophila melanogaster	92-98
34494836-2	2021	As one of the most heavily glycosylated TLR family members, the role of glycan at N413 of TLR3 in ligand recognition has been in debate for decades.	Polysaccharides	72-78	toll like receptor 3	Homo sapiens	40-43
34567092-2	2021	Clinical exome sequencing revealed complex alleles in ALG1, the encoding gene for the chitobiosyldiphosphodolichol beta-mannosyltransferase that participates in the formation of the dolichol-pyrophosphate-GlcNAc2Man5, a lipid-linked glycan intermediate during N-glycan synthesis.	Polysaccharides	233-239	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	54-58
34567092-2	2021	Clinical exome sequencing revealed complex alleles in ALG1, the encoding gene for the chitobiosyldiphosphodolichol beta-mannosyltransferase that participates in the formation of the dolichol-pyrophosphate-GlcNAc2Man5, a lipid-linked glycan intermediate during N-glycan synthesis.	Polysaccharides	233-239	ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase	Homo sapiens	86-139
34494836-2	2021	As one of the most heavily glycosylated TLR family members, the role of glycan at N413 of TLR3 in ligand recognition has been in debate for decades.	Polysaccharides	72-78	toll like receptor 3	Homo sapiens	90-94
34432454-0	2021	Noni (Morinda citrifolia L.) Fruit Polysaccharides Regulated IBD Mice Via Targeting Gut Microbiota: Association of JNK/ERK/NF-kappaB Signaling Pathways.	Polysaccharides	35-50	mitogen-activated protein kinase 1	Mus musculus	119-122
34494836-3	2021	Herein, to investigate the role of glycans in TLR3, specifically at amino acid residue N413, molecular dynamic simulations were performed.	Polysaccharides	35-42	toll like receptor 3	Homo sapiens	46-50
34494836-5	2021	The glycan at N413 not only prevented dsRNA from being exposed to the bulk water during the binding process but further stabilized dsRNA in the TLR3 binding site.	Polysaccharides	4-10	toll like receptor 3	Homo sapiens	144-148
34481488-4	2021	RESULTS: In the current study, we investigated the therapeutic capability of a novel semi-synthetic sulfated polysaccharide (SAGE) on the production of cytokines and MMPs by cultured human mononuclear cells and macrophages stimulated with endotoxin LPS produced by P. gingivalis, a periodontally-relevant cell culture model.	Polysaccharides	109-123	sarcoma antigen 1	Homo sapiens	125-129
34494836-8	2021	In all, these results demonstrate that the size, length, and branch of glycan at N413 affect the thermodynamics and dynamics of TLR3 recognition with dsRNA.	Polysaccharides	71-77	toll like receptor 3	Homo sapiens	128-132
34494836-9	2021	This study further extends our understanding of the biological role of glycans in the innate immune recognition of dsRNA by TLR3 and provides a new perspective for modulating TLR3 function.	Polysaccharides	71-78	toll like receptor 3	Homo sapiens	124-128
34494836-9	2021	This study further extends our understanding of the biological role of glycans in the innate immune recognition of dsRNA by TLR3 and provides a new perspective for modulating TLR3 function.	Polysaccharides	71-78	toll like receptor 3	Homo sapiens	175-179
34111288-5	2021	METHODS: We developed a method for specifically and sensitively detecting in-vivo PL products, based on Driselase digestion of cell-wall polysaccharides and detection of the characteristic unsaturated product of PL action.	Polysaccharides	137-152	pectate lyase	Phoenix dactylifera	82-84
34415013-5	2021	Based on these associations, AAL cassettes were proposed to encode a noncanonical Acp-dependent polysaccharide modification route.	Polysaccharides	96-110	NADH:ubiquinone oxidoreductase subunit AB1	Homo sapiens	82-85
34428035-5	2021	By installing FRET acceptors on the glycan of targeted EpCAM glycoprotein using the metabolic glycan labeling and click chemistry, FRET signals appear on the cancerous cell membranes, not normal cells, when donors and acceptors are within an appropriate distance.	Polysaccharides	36-42	epithelial cell adhesion molecule	Homo sapiens	55-60
34428035-5	2021	By installing FRET acceptors on the glycan of targeted EpCAM glycoprotein using the metabolic glycan labeling and click chemistry, FRET signals appear on the cancerous cell membranes, not normal cells, when donors and acceptors are within an appropriate distance.	Polysaccharides	94-100	epithelial cell adhesion molecule	Homo sapiens	55-60
34415762-6	2021	Although HLA-A displays the broadest variety of glycan characteristics, HLA-B alpha-chains carry mostly mature glycans, and HLA-C and HLA-F alpha-chains carry predominantly high-mannose glycans.	Polysaccharides	48-54	major histocompatibility complex, class I, A	Homo sapiens	9-14
34463614-7	2021	Interestingly, the Spike protein possesses many post-translational modifications, in the form of branched glycans that flank the surface of the assembly.	Polysaccharides	106-113	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	19-24
34175821-1	2021	polysaccharides (SPP) against RSV (respiratory syncytial virus) infection: Antiviral effect and mechanisms of action.	Polysaccharides	0-15	sphingosine-1-phosphate phosphatase 1	Mus musculus	17-20
34119127-7	2021	Besides, HA is an endogenous polysaccharide that shows intrinsic targetability to CD44 receptors on surface of cancer cells.	Polysaccharides	29-43	CD44 molecule (Indian blood group)	Homo sapiens	82-86
34119144-4	2021	Here, we showed novel structure of a homogeneous polysaccharide named LRP1-S2 from this fruit and its anti-pancreatic cancer effect.	Polysaccharides	49-63	LDL receptor related protein 1	Homo sapiens	70-74
34399540-4	2021	The present review pursues three aims: 1) to introduce several well-known dietary polysaccharides (chitosan, dextran and alginate) and proteins (whey protein and lysozyme); 2) to discuss the types, preparation methods, chemical interactions and properties of various biocompatible complex carriers; 3) to present the application and prospect of polysaccharide-protein complex in bioactive ingredient delivery, nutrient encapsulation and flavor protection.	Polysaccharides	345-359	lysozyme like 2	Homo sapiens	162-174
34274454-0	2021	Development of a pneumococcal conjugate vaccine based on chemical conjugation of polysaccharide serotype 6B to PspA.	Polysaccharides	81-95	surfactant associated protein A1	Mus musculus	111-115
34174425-6	2021	However, in Aspergilli, deletion of the ALG3 homolog algC leads to an N-glycan pool where the majority of the structures contain more hexose residues than the Man3-5GlcNAc2 species that can serve as substrates for humanized glycan structures.	Polysaccharides	224-230	dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase	Saccharomyces cerevisiae S288C	40-44
34463614-10	2021	These simulations indicate that the steric composition of the glycans can induce a pause during the Spike protein conformational change.	Polysaccharides	62-69	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	100-105
34484564-1	2021	The original Laminaria polysaccharide (LP0) was sulfated using the sulfur trioxide-pyridine method, and four sulfated Laminaria polysaccharides (SLPs) were obtained, namely, SLP1, SLP2, SLP3, and SLP4.	Polysaccharides	23-37	ribosomal protein lateral stalk subunit P0	Homo sapiens	39-42
34166692-1	2021	The study was aimed to investigate the simulated digestion behavior of the bioactive polysaccharides from Chimonanthus nitens Oliv (COP1), antioxidant activity in vitro, and prevention against cyclophosphamide (CP) induced oxidative damage in mice.	Polysaccharides	85-100	COP1, E3 ubiquitin ligase	Mus musculus	132-136
34502965-1	2021	The aim of this paper is to investigate the interactions between polysaccharides with different electrical charges (anionic and neutral starches) and proteins and fats in food ingredients.	Polysaccharides	65-80	chromosome 10 open reading frame 90	Homo sapiens	163-167
34166919-7	2021	As this polysaccharide is a sialic acid homopolymer, these results indicate that Igkv4-57j4 encodes a VL common to immunoglobulins that recognize sialylated glycans.	Polysaccharides	8-22	immunoglobulin kappa chain variable 4 (V4)	Mus musculus	81-86
34166919-7	2021	As this polysaccharide is a sialic acid homopolymer, these results indicate that Igkv4-57j4 encodes a VL common to immunoglobulins that recognize sialylated glycans.	Polysaccharides	157-164	immunoglobulin kappa chain variable 4 (V4)	Mus musculus	81-86
34379416-3	2021	Using all-atom molecular dynamics (MD) simulations and Markov state modeling (MSM), we unveil the influence of glycans on the conformational flexibility of the multidomain protein disulfide isomerase (PDI), which is a ubiquitous chaperone in the endoplasmic reticulum (ER).	Polysaccharides	111-118	protein disulfide isomerase family A member 2	Homo sapiens	201-204
34379416-5	2021	We compare simulations of glycosylated and unglycosylated yPDI and find that the presence of glycan-glycan and glycan-protein interactions influences the flexibility of PDI in different ways.	Polysaccharides	111-117	protein disulfide isomerase family A member 2	Homo sapiens	169-172
34484564-1	2021	The original Laminaria polysaccharide (LP0) was sulfated using the sulfur trioxide-pyridine method, and four sulfated Laminaria polysaccharides (SLPs) were obtained, namely, SLP1, SLP2, SLP3, and SLP4.	Polysaccharides	23-37	synaptotagmin like 1	Homo sapiens	174-178
34484564-1	2021	The original Laminaria polysaccharide (LP0) was sulfated using the sulfur trioxide-pyridine method, and four sulfated Laminaria polysaccharides (SLPs) were obtained, namely, SLP1, SLP2, SLP3, and SLP4.	Polysaccharides	23-37	synaptotagmin like 2	Homo sapiens	180-184
34484564-1	2021	The original Laminaria polysaccharide (LP0) was sulfated using the sulfur trioxide-pyridine method, and four sulfated Laminaria polysaccharides (SLPs) were obtained, namely, SLP1, SLP2, SLP3, and SLP4.	Polysaccharides	23-37	synaptotagmin like 3	Homo sapiens	186-190
34484564-6	2021	The biological activity of the polysaccharides increased with the content of -OSO3 -, that is, the biological activities of the polysaccharides had the following order: LP0 < SLP1 < SLP2 < SLP3 < SLP4.	Polysaccharides	31-46	ribosomal protein lateral stalk subunit P0	Homo sapiens	169-172
34484564-6	2021	The biological activity of the polysaccharides increased with the content of -OSO3 -, that is, the biological activities of the polysaccharides had the following order: LP0 < SLP1 < SLP2 < SLP3 < SLP4.	Polysaccharides	31-46	synaptotagmin like 1	Homo sapiens	175-179
34484564-6	2021	The biological activity of the polysaccharides increased with the content of -OSO3 -, that is, the biological activities of the polysaccharides had the following order: LP0 < SLP1 < SLP2 < SLP3 < SLP4.	Polysaccharides	31-46	synaptotagmin like 2	Homo sapiens	182-186
34484564-6	2021	The biological activity of the polysaccharides increased with the content of -OSO3 -, that is, the biological activities of the polysaccharides had the following order: LP0 < SLP1 < SLP2 < SLP3 < SLP4.	Polysaccharides	31-46	synaptotagmin like 3	Homo sapiens	189-193
34484564-6	2021	The biological activity of the polysaccharides increased with the content of -OSO3 -, that is, the biological activities of the polysaccharides had the following order: LP0 < SLP1 < SLP2 < SLP3 < SLP4.	Polysaccharides	31-46	sphingosine-1-phosphate receptor 4	Homo sapiens	196-200
34484564-6	2021	The biological activity of the polysaccharides increased with the content of -OSO3 -, that is, the biological activities of the polysaccharides had the following order: LP0 < SLP1 < SLP2 < SLP3 < SLP4.	Polysaccharides	128-143	ribosomal protein lateral stalk subunit P0	Homo sapiens	169-172
34232076-5	2021	We found that immunoreactivity of O139-specific polysaccharides with antibodies elicited by wild-type infection markedly increase when saccharides contain colitose and phosphate residues, that a synthetic terminal tetrasaccharide fragment of OSP is more immunoreactive and protectively immunogenic than complete OSP, that native OSP-core is a better protective immunogen than the synthetic OSP lacking core, and that functional vibriocidal activity of antibodies predicts in vivo protection in our model but depends on capsule thickness.	Polysaccharides	48-63	claudin 11	Homo sapiens	242-245
34484564-6	2021	The biological activity of the polysaccharides increased with the content of -OSO3 -, that is, the biological activities of the polysaccharides had the following order: LP0 < SLP1 < SLP2 < SLP3 < SLP4.	Polysaccharides	128-143	synaptotagmin like 1	Homo sapiens	175-179
34232076-5	2021	We found that immunoreactivity of O139-specific polysaccharides with antibodies elicited by wild-type infection markedly increase when saccharides contain colitose and phosphate residues, that a synthetic terminal tetrasaccharide fragment of OSP is more immunoreactive and protectively immunogenic than complete OSP, that native OSP-core is a better protective immunogen than the synthetic OSP lacking core, and that functional vibriocidal activity of antibodies predicts in vivo protection in our model but depends on capsule thickness.	Polysaccharides	48-63	claudin 11	Homo sapiens	329-332
34484564-6	2021	The biological activity of the polysaccharides increased with the content of -OSO3 -, that is, the biological activities of the polysaccharides had the following order: LP0 < SLP1 < SLP2 < SLP3 < SLP4.	Polysaccharides	128-143	synaptotagmin like 2	Homo sapiens	182-186
34232076-5	2021	We found that immunoreactivity of O139-specific polysaccharides with antibodies elicited by wild-type infection markedly increase when saccharides contain colitose and phosphate residues, that a synthetic terminal tetrasaccharide fragment of OSP is more immunoreactive and protectively immunogenic than complete OSP, that native OSP-core is a better protective immunogen than the synthetic OSP lacking core, and that functional vibriocidal activity of antibodies predicts in vivo protection in our model but depends on capsule thickness.	Polysaccharides	48-63	claudin 11	Homo sapiens	390-393
34232076-8	2021	Protection against cholera is serogroup specific, and serogroup specificity is defined by O-specific polysaccharide (OSP).	Polysaccharides	101-115	claudin 11	Homo sapiens	117-120
34484564-6	2021	The biological activity of the polysaccharides increased with the content of -OSO3 -, that is, the biological activities of the polysaccharides had the following order: LP0 < SLP1 < SLP2 < SLP3 < SLP4.	Polysaccharides	128-143	synaptotagmin like 3	Homo sapiens	189-193
34484564-6	2021	The biological activity of the polysaccharides increased with the content of -OSO3 -, that is, the biological activities of the polysaccharides had the following order: LP0 < SLP1 < SLP2 < SLP3 < SLP4.	Polysaccharides	128-143	sphingosine-1-phosphate receptor 4	Homo sapiens	196-200
34419057-7	2021	Additionally, in the absence of calcium, this sulfatase binds to the sulfated glycan but does not remove the sulfate group, suggesting it could be used for selective isolation of sulfated N-glycans.	Polysaccharides	78-84	arylsulfatase family member H	Homo sapiens	46-55
34416923-1	2021	BACKGROUND: TNF-alpha-stimulated gene 6 (TSG-6) protein, a TNF-alpha-responsive hyaladherin, possesses enzymatic activity that can catalyze covalent crosslinks of the polysaccharide hyaluronic acid (HA) to another protein to form heavy chain-hyaluronic acid (HC-HA) complexes in pathological conditions such as osteoarthritis (OA).	Polysaccharides	167-181	TNF alpha induced protein 6	Equus caballus	41-46
34416923-1	2021	BACKGROUND: TNF-alpha-stimulated gene 6 (TSG-6) protein, a TNF-alpha-responsive hyaladherin, possesses enzymatic activity that can catalyze covalent crosslinks of the polysaccharide hyaluronic acid (HA) to another protein to form heavy chain-hyaluronic acid (HC-HA) complexes in pathological conditions such as osteoarthritis (OA).	Polysaccharides	167-181	tumor necrosis factor	Equus caballus	59-68
34383769-7	2021	In antibiotic-treated animals, IL-22-induced a specific set of genes including Fut2, encoding fucosyl-transferase 2 that participates in the biosynthesis of fucosylated glycans which can mediate rotavirus binding.	Polysaccharides	169-176	interleukin 22	Mus musculus	31-36
34452053-1	2021	The Receptor-Binding Domain (RBD) of the Spike (S) protein from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has glycosylation sites which can limit the production of reliable antigens expressed in prokaryotic platforms, due to glycan-mediated evasion of the host immune response.	Polysaccharides	244-250	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	41-46
34452053-1	2021	The Receptor-Binding Domain (RBD) of the Spike (S) protein from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has glycosylation sites which can limit the production of reliable antigens expressed in prokaryotic platforms, due to glycan-mediated evasion of the host immune response.	Polysaccharides	244-250	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	48-49
34351736-3	2021	We report here a facile synthesis of functionalized glycan oxazolines from free sialoglycans that are key donor substrates for enzymatic Fc glycan remodeling and the application of an efficient endoglycosidase mutant (Endo-S2 D184M) for site-specific glycan transfer to construct homogeneous ADCs.	Polysaccharides	251-257	mannosidase endo-alpha	Homo sapiens	218-222
34351736-5	2021	We further demonstrated that the recently reported Endo-S2 D184 M mutant was highly efficient for Fc glycan remodeling with the selectively modified glycan oxazolines to introduce tags into an antibody, which required a significantly smaller amount of glycan oxazolines and a much shorter reaction time than that of the Endo-S D233Q-catalyzed reaction, thus minimizing the side reactions.	Polysaccharides	101-107	mannosidase endo-alpha	Homo sapiens	51-55
34351736-5	2021	We further demonstrated that the recently reported Endo-S2 D184 M mutant was highly efficient for Fc glycan remodeling with the selectively modified glycan oxazolines to introduce tags into an antibody, which required a significantly smaller amount of glycan oxazolines and a much shorter reaction time than that of the Endo-S D233Q-catalyzed reaction, thus minimizing the side reactions.	Polysaccharides	101-107	mannosidase endo-alpha	Homo sapiens	320-324
34385330-8	2021	Enzymatic assays of tagged proteins expressed in vivo or of purified recombinant FUT1 showed it had a broad fucosyltransferase activity including glycan and peptide substrates.	Polysaccharides	146-152	fucosyltransferase 1 (H blood group)	Homo sapiens	81-85
34293617-8	2021	Moreover, docking experiments revealed the presence of hydrogen bond interactions between the N-acetyl group of the glucosaminopyranose moiety of the evaluated galactosides and specific amino acid residues of Gal-1, relevant for galectin-glycan affinity.	Polysaccharides	238-244	galectin 1	Homo sapiens	209-214
34260218-2	2021	We designed a trimeric, highly thermotolerant glycan engineered RBD by fusion to a heterologous, poorly immunogenic disulfide linked trimerization domain derived from cartilage matrix protein.	Polysaccharides	46-52	matrilin 1	Homo sapiens	167-191
34323486-6	2021	Moreover, the favorable performance of 5h in interfering with c-di-GMP-related biological functions, including bacterial motility and bacterial extracellular polysaccharide secretion, combined with the reporter strain and transcriptome analysis results confirmed the c-di-GMP signaling-related action mechanism of 5h.	Polysaccharides	158-172	5'-nucleotidase, cytosolic II	Homo sapiens	67-70
34603676-2	2021	Functionalization of therapeutic lysosomal enzymes with mannose-6-phosphate (M6P) glycan ligands represents a major strategy for enhancing the cation-independent M6P receptor (CI-MPR)-mediated cellular uptake, thus improving the overall therapeutic efficacy of the enzymes.	Polysaccharides	80-88	insulin like growth factor 2 receptor	Homo sapiens	143-174
34603676-2	2021	Functionalization of therapeutic lysosomal enzymes with mannose-6-phosphate (M6P) glycan ligands represents a major strategy for enhancing the cation-independent M6P receptor (CI-MPR)-mediated cellular uptake, thus improving the overall therapeutic efficacy of the enzymes.	Polysaccharides	80-88	insulin like growth factor 2 receptor	Homo sapiens	176-182
34603676-5	2021	Structure-activity relationship studies identified M6P tetrasaccharide oxazoline as the minimal substrate for enzymatic transglycosylation yielding high-affinity M6P glycan ligands for the CI-MPR.	Polysaccharides	166-172	insulin like growth factor 2 receptor	Homo sapiens	189-195
34228490-2	2021	IgG- and IgA-secreting memory B cells (MBC) targeting the V. cholerae O-specific polysaccharide (OSP) correlate with protection from infection in persons exposed to V. cholerae and may be a major determinant of long-term protection from cholera.	Polysaccharides	81-95	claudin 11	Homo sapiens	97-100
34293617-0	2021	Structural insights in galectin-1-glycan recognition: Relevance of the glycosidic linkage and the N-acetylation pattern of sugar moieties.	Polysaccharides	34-40	galectin 1	Homo sapiens	23-33
34339169-6	2021	Our biophysical analysis using glycan arrays and surface plasmon resonance demonstrated that Ata binds galactose, N-acetylglucosamine, and galactose (beta1-3/4) N-acetylglucosamine with high-affinity.	Polysaccharides	31-37	ATM serine/threonine kinase	Homo sapiens	93-96
34339169-8	2021	We also demonstrated that the recognition of human plasma fibronectin by Ata requires this ability to bind glycans, as the interaction between Ata and fibronectin does not occur when fibronectin is deglycosylated.	Polysaccharides	107-114	fibronectin 1	Homo sapiens	58-69
34339169-8	2021	We also demonstrated that the recognition of human plasma fibronectin by Ata requires this ability to bind glycans, as the interaction between Ata and fibronectin does not occur when fibronectin is deglycosylated.	Polysaccharides	107-114	ATM serine/threonine kinase	Homo sapiens	73-76
34339169-8	2021	We also demonstrated that the recognition of human plasma fibronectin by Ata requires this ability to bind glycans, as the interaction between Ata and fibronectin does not occur when fibronectin is deglycosylated.	Polysaccharides	107-114	ATM serine/threonine kinase	Homo sapiens	143-146
34383769-7	2021	In antibiotic-treated animals, IL-22-induced a specific set of genes including Fut2, encoding fucosyl-transferase 2 that participates in the biosynthesis of fucosylated glycans which can mediate rotavirus binding.	Polysaccharides	169-176	fucosyltransferase 2	Mus musculus	79-83
34383769-7	2021	In antibiotic-treated animals, IL-22-induced a specific set of genes including Fut2, encoding fucosyl-transferase 2 that participates in the biosynthesis of fucosylated glycans which can mediate rotavirus binding.	Polysaccharides	169-176	fucosyltransferase 2	Mus musculus	94-115
34441764-7	2021	To elucidate the pathogenesis of IgAN, it is important to deconvolute the biosynthetic origins of Gd-IgA1 and characterize the pathogenic IgA1 HR O-glycoform(s), including the glycan structures and their sites of attachment.	Polysaccharides	176-182	IGAN1	Homo sapiens	33-37
34328324-2	2021	However, the molecular structures and glycan heterogeneity of the new O-glycans found on the S protein regional-binding domain (S-RBD) remain cryptic because of the challenges in intact glycoform analysis by conventional bottom-up glycoproteomic approaches.	Polysaccharides	38-44	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	128-129
34160251-10	2021	Different viral features have been associated with the development of broadly neutralizing antibodies, including the glycan shield on the surface of the HIV-1 Envelope (Env).	Polysaccharides	117-123	endogenous retrovirus group K member 20	Homo sapiens	169-172
34160251-12	2021	We compared Env glycan features in HIV-1 sequences obtained in early infection to the potency and breadth of neutralizing antibodies measured one to three years after infection.	Polysaccharides	16-22	endogenous retrovirus group K member 20	Homo sapiens	12-15
34185704-6	2021	Following anti-IL-13 treatment in infected mice, hyaluronan synthase 1 (Has1) was the most downregulated gene and accumulation of the hyaluronan polysaccharide was decreased in the lung.	Polysaccharides	145-159	interleukin 13	Mus musculus	15-20
34369876-3	2021	Here, we demonstrate a critical role for the glycan-binding protein galectin-9 in setting the threshold of B cell activation and that loss of this regulatory network is sufficient to drive spontaneous autoimmunity.	Polysaccharides	45-51	lectin, galactose binding, soluble 9	Mus musculus	68-78
34441764-7	2021	To elucidate the pathogenesis of IgAN, it is important to deconvolute the biosynthetic origins of Gd-IgA1 and characterize the pathogenic IgA1 HR O-glycoform(s), including the glycan structures and their sites of attachment.	Polysaccharides	176-182	immunoglobulin heavy constant alpha 1	Homo sapiens	138-142
34294193-7	2021	Cmah-/-mdx mice can be induced to develop anti-Neu5Gc-glycan antibodies as humans do.	Polysaccharides	54-60	cytidine monophospho-N-acetylneuraminic acid hydroxylase	Mus musculus	0-4
34413784-1	2021	This study aimed to investigate the effects of Morchella importuna polysaccharides (MIPs) on carbon tetrachloride (CCl4)-induced hepatic damage in mice.	Polysaccharides	67-82	chemokine (C-C motif) ligand 4	Mus musculus	115-119
34132294-8	2021	Taken together, these results suggested that polysaccharides suppress H2O2-induced cell invasion by inhibiting Myc-mediated MMP-9 gene transcription through the MAPK signaling pathway in A549 and NCI-H1650 cells.	Polysaccharides	45-60	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	111-114
34132294-8	2021	Taken together, these results suggested that polysaccharides suppress H2O2-induced cell invasion by inhibiting Myc-mediated MMP-9 gene transcription through the MAPK signaling pathway in A549 and NCI-H1650 cells.	Polysaccharides	45-60	matrix metallopeptidase 9	Homo sapiens	124-129
34126149-6	2021	The two polysaccharides have potential for inhibiting alpha-glucosidase and alpha-amylase activities, suppressing HepG-2, A549 and MCF-7 cancer cells proliferation, and activating macrophage RAW 264.7 cells to secret immune cytokines for mediating cellular immune response.	Polysaccharides	8-23	sucrase-isomaltase	Homo sapiens	54-71
34451652-0	2021	An Apoplastic Defensin of Wheat Elicits the Production of Extracellular Polysaccharides in Snow Mold.	Polysaccharides	72-87	defensin Tk-AMP-D2	Triticum aestivum	14-22
34451652-3	2021	When M. nivale was treated with TAD1, Congo red-stainable extracellular polysaccharides (EPS) were produced.	Polysaccharides	72-87	defensin Tk-AMP-D2	Triticum aestivum	32-36
34315394-3	2022	METHODS: Cytotoxicity of the polysaccharides against MDA-MB-231 and MCF-7 cell lines along with their impact on CD44+/CD24- and aldehyde dehydrogenase 1(ALDH1) positive BCSC population were determined.	Polysaccharides	29-44	CD44 molecule (Indian blood group)	Homo sapiens	112-116
34360993-8	2021	Glycan analysis indicates that predominant glycoforms HexNAc2Hex8 and HexNAc2Hex11 are found at Asn119, Asn378, and Asn743, three of the canonical four N-glycosylation sites of human CP.	Polysaccharides	0-6	ceruloplasmin	Homo sapiens	183-185
34360826-9	2021	Amongst the detected glycoforms, the presence of glycans bearing ABO(H) antigens allowed us to define a distinctive spectrum for each blood group.	Polysaccharides	49-56	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	65-68
34315394-3	2022	METHODS: Cytotoxicity of the polysaccharides against MDA-MB-231 and MCF-7 cell lines along with their impact on CD44+/CD24- and aldehyde dehydrogenase 1(ALDH1) positive BCSC population were determined.	Polysaccharides	29-44	CD24 molecule	Homo sapiens	118-122
34315394-3	2022	METHODS: Cytotoxicity of the polysaccharides against MDA-MB-231 and MCF-7 cell lines along with their impact on CD44+/CD24- and aldehyde dehydrogenase 1(ALDH1) positive BCSC population were determined.	Polysaccharides	29-44	aldehyde dehydrogenase 1 family member A1	Homo sapiens	153-158
34315394-8	2022	Significant suppression of Cyclin D1 gene expression was noted in MDA-MB-231 and MCF-7 cells treated with P. capillacea or C. officinalis polysaccharides.	Polysaccharides	138-153	cyclin D1	Homo sapiens	27-36
34301890-10	2021	Thus, we conclude that galectin-3 amplifies caspase-4/11 oligomerization and activation through LPS glycan binding, resulting in more intense pyroptosis-a critical mechanism of host resistance against bacterial infection that may provide opportunities for new therapeutic interventions.	Polysaccharides	100-106	galectin 3	Homo sapiens	23-33
34366713-2	2021	Polysaccharides (GBP) extracted from Gastrodia elata Blume have been demonstrated to possess anti-inflammatory and neuroprotective effects in vivo; however, the effects of GBP on Vin-induced neuropathic pain remain unknown.	Polysaccharides	0-15	transmembrane protein 132A	Rattus norvegicus	17-20
34231555-2	2021	Recent studies have demonstrated that glycan isomers with the terminal galactose position on either the Man alpha1-3 arm or the Man alpha1-6 arm have an impact on the effector functions and dynamic structure of mAbs.	Polysaccharides	38-44	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	108-116
34231555-2	2021	Recent studies have demonstrated that glycan isomers with the terminal galactose position on either the Man alpha1-3 arm or the Man alpha1-6 arm have an impact on the effector functions and dynamic structure of mAbs.	Polysaccharides	38-44	immunoglobulin kappa variable 3-31 (pseudogene)	Homo sapiens	132-140
34301890-10	2021	Thus, we conclude that galectin-3 amplifies caspase-4/11 oligomerization and activation through LPS glycan binding, resulting in more intense pyroptosis-a critical mechanism of host resistance against bacterial infection that may provide opportunities for new therapeutic interventions.	Polysaccharides	100-106	caspase 4	Homo sapiens	44-56
34192455-0	2021	Proangiogenic Collagen-Binding Glycan Therapeutic Promotes Endothelial Cell Angiogenesis.	Polysaccharides	31-37	collagen type III alpha 1 chain	Gallus gallus	14-22
34485021-5	2021	Bisected glycans were decreased in the severe GALT c.563A-G/p.Gln188Arg homozygous cohort (n = 49) (P < .05).	Polysaccharides	9-16	galactose-1-phosphate uridylyltransferase	Homo sapiens	46-50
34485021-6	2021	Logistic regression models incorporating IgG glycan traits distinguished CG patients from controls.	Polysaccharides	45-51	cathepsin G	Homo sapiens	73-75
34256630-0	2021	Structure/function relationships of bean polysaccharides: A review.	Polysaccharides	41-56	brain expressed associated with NEDD4 1	Homo sapiens	36-40
34256630-2	2021	This review aims to provide a foundation for the future research and development of bean polysaccharides, by summarizing the sources, structure, and functions of bioactive bean polysaccharides.	Polysaccharides	89-104	brain expressed associated with NEDD4 1	Homo sapiens	84-88
34256630-2	2021	This review aims to provide a foundation for the future research and development of bean polysaccharides, by summarizing the sources, structure, and functions of bioactive bean polysaccharides.	Polysaccharides	89-104	brain expressed associated with NEDD4 1	Homo sapiens	172-176
34256630-2	2021	This review aims to provide a foundation for the future research and development of bean polysaccharides, by summarizing the sources, structure, and functions of bioactive bean polysaccharides.	Polysaccharides	177-192	brain expressed associated with NEDD4 1	Homo sapiens	84-88
34256630-2	2021	This review aims to provide a foundation for the future research and development of bean polysaccharides, by summarizing the sources, structure, and functions of bioactive bean polysaccharides.	Polysaccharides	177-192	brain expressed associated with NEDD4 1	Homo sapiens	172-176
34256630-4	2021	This will provide useful guidance for further optimization of polysaccharide structure and the development of bean polysaccharides as a novel functional material.	Polysaccharides	115-130	brain expressed associated with NEDD4 1	Homo sapiens	110-114
34312429-7	2021	Relative binding free energy of RBD-ACE2 is also more favorable in the O-glycosylated models with longer glycans.	Polysaccharides	105-112	angiotensin converting enzyme 2	Homo sapiens	36-40
34451811-4	2021	Overall, these data support the notion that sulfated glycan extracted from the red alga B. occidentalis, BoSG, can exert neuroprotection against HIV-1 Tat and gp120, potentially via direct molecular interactions.	Polysaccharides	53-59	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	159-164
34236183-3	2021	Though mammalian glycans incorporate only the pyranose form of galactose (Galp), many pathogens, including Mycobacterium tuberculosis and Klebsiella pneumoniae, contain galactofuranose (Galf) residues in their cell envelope.	Polysaccharides	17-24	galanin like peptide	Homo sapiens	74-78
34272452-6	2021	Both gene ontology (GO) and The Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses demonstrated that CTSA co-expressed genes were involved in ATP hydrolysis coupled proton transport, carbohydrate metabolic process, lysosome organization, oxidative phosphorylation, other glycan degradation, etc.	Polysaccharides	276-282	cathepsin A	Homo sapiens	106-110
34213308-5	2021	Molecular dynamics simulations of a fully glycosylated spike support a model of steric restrictions that shape enzymatic processing of the glycans.	Polysaccharides	139-146	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	55-60
34170660-5	2021	Four modified polysaccharides with carboxyl group (-COOH) contents of 3.92% (CSP0), 7.75% (CCSP1), 12.90% (CCSP2), and 16.38% (CCSP3) were obtained.	Polysaccharides	14-29	cell migration inducing hyaluronidase 1	Homo sapiens	91-96
34170660-5	2021	Four modified polysaccharides with carboxyl group (-COOH) contents of 3.92% (CSP0), 7.75% (CCSP1), 12.90% (CCSP2), and 16.38% (CCSP3) were obtained.	Polysaccharides	14-29	von Willebrand factor A domain containing 2	Homo sapiens	107-112
34238357-0	2021	A bivalent protein targeting glycans and HR1 domain in spike protein potently inhibited infection of SARS-CoV-2 and other human coronaviruses.	Polysaccharides	29-36	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	55-60
34215698-6	2021	However, the cytotoxicity caused by FBS2 was restored by the overexpression of "glycan-less" NRF1 mutants, regardless of their transcriptional activity, or by the deletion of NRF1 in NGLY1-KO cells.	Polysaccharides	80-86	F-box protein 6	Mus musculus	36-40
34307449-6	2021	Glycans including sialic acid, gangliosides, histo-blood group antigens (HBGAs), and mucin cores have been reported to interact with RV VP8*s. The glycan binding specificities of VP8*s of different RV genotypes have been studied.	Polysaccharides	0-7	LOC100508689	Homo sapiens	85-90
34215698-6	2021	However, the cytotoxicity caused by FBS2 was restored by the overexpression of "glycan-less" NRF1 mutants, regardless of their transcriptional activity, or by the deletion of NRF1 in NGLY1-KO cells.	Polysaccharides	80-86	nuclear respiratory factor 1	Homo sapiens	93-97
34087306-2	2021	The activity of GDNF is highly dependent on the interaction with sulfated glycans which bind at the N-terminus consisting of 19 residues.	Polysaccharides	74-81	glial cell derived neurotrophic factor	Homo sapiens	16-20
34335974-0	2021	Environmentally-induced mdig contributes to the severity of COVID-19 through fostering expression of SARS-CoV-2 receptor NRPs and glycan metabolism.	Polysaccharides	130-136	ribosomal oxygenase 2	Homo sapiens	24-28
34335974-4	2021	In the present report, we provided evidence showing that mdig, a previously reported environmentally-induced oncogene that antagonizes repressive trimethylation of histone proteins, is an important regulator for SARS-CoV-2 receptors neuropilin-1 (NRP1) and NRP2, cathepsins, glycan metabolism and inflammation, key determinants for viral infection and cytokine storm of the patients.	Polysaccharides	275-281	ribosomal oxygenase 2	Homo sapiens	57-61
34281251-6	2021	Alterations in ApoE glycosylation have been observed in the course of diseases such as preeclampsia or breast cancer, but little is known about the characteristics of ApoE glycans analyzed in human seminal and blood serum/plasma in the context of male reproductive health.	Polysaccharides	172-179	apolipoprotein E	Homo sapiens	167-171
34281251-7	2021	A deeper analysis of ApoE glycosylation in the context of female and male fertility will both enable us to broaden our knowledge of the biochemical and cellular mechanisms in which glycans participate, having a direct or indirect relationship with the fertilization process, and also give us a chance of contributing to the enrichment of the diagnostic panel in infertile women and men, which is particularly important in procedures involved in assisted reproductive techniques.	Polysaccharides	181-188	apolipoprotein E	Homo sapiens	21-25
34089345-1	2021	The macrophage mannose receptor (CD206, MR) is an endocytic lectin receptor which plays an important role in homeostasis and innate immunity, however, the endogenous glycan and glycoprotein ligands recognized by its C-type lectin domains (CTLD) have not been well studied.	Polysaccharides	166-172	mannose receptor, C type 1	Mus musculus	33-38
34087306-3	2021	Herein, we studied the influence of different glycosaminoglycan (i.e., glycan; GAG) molecules on the conformation of a GDNF-derived peptide (GAG binding motif, sixteen amino acid residues at the N-terminus) using both experimental and theoretical studies.	Polysaccharides	71-77	glial cell derived neurotrophic factor	Homo sapiens	119-123
34080298-0	2021	Astragalus polysaccharide attenuates LPS-related inflammatory osteolysis by suppressing osteoclastogenesis by reducing the MAPK signalling pathway.	Polysaccharides	11-25	mitogen-activated protein kinase 1	Homo sapiens	123-127
34281204-6	2021	In addition, the MAT1-2 strains showed an enhanced ability to degrade complex polysaccharides, especially starch, pectin, and cellulose.	Polysaccharides	78-93	S-adenosylmethionine synthase 1	Solanum tuberosum	17-21
34181947-1	2021	The human mannose receptor plays an important role in scavenging a variety of glycans and glycoconjugates which contributes to both innate and adaptive immunity.	Polysaccharides	78-85	mannose receptor C-type 1	Homo sapiens	10-26
34323037-10	2021	AZI-RHL NPs displayed the capacity to effectively destroy the biofilm structure and remove the proteins and polysaccharides in EPS, eradicating biofilms in addition to reducing the survival rate of bacteria in the biofilm.	Polysaccharides	108-123	antizyme inhibitor 1	Homo sapiens	0-3
34112396-1	2021	Our previous study has demonstrated that sulfated yam polysaccharide (SCYP) had a stronger immunomodulatory activity than yam polysaccharide (CYP).	Polysaccharides	126-140	peptidyl-prolyl isomerase G (cyclophilin G)	Mus musculus	142-145
34156262-4	2021	Three mouse NAbs potently neutralized BG505.T332N by recognizing a glycan epitope centered in the C3/V4 region on BG505 Env, as revealed by electron microscopy (EM), X-ray crystallography, and epitope mapping.	Polysaccharides	67-73	melanoma antigen	Mus musculus	120-123
34156262-6	2021	Neutralization assays against BG505.T332N variants confirmed that potent rabbit NAbs targeted previously described glycan holes on BG505 Env and accounted for a significant portion of the autologous NAb response in both the trimer and ferritin NP groups.	Polysaccharides	115-121	melanoma antigen	Mus musculus	137-140
34156262-12	2021	In the present study, monoclonal NAbs were isolated from previously immunized mice and rabbits for structural and functional analyses, which revealed that potent mouse NAbs recognize the C3/V4 region and small NP-elicited rabbit NAbs primarily target known glycan holes on BG505 Env.	Polysaccharides	257-263	melanoma antigen	Mus musculus	279-282
34204215-2	2021	Chitosan (CS), as a biodegradable and biocompatible polysaccharide, is considered to be an excellent template for the design of a hybrid biopolymer-based metal oxide nanocomposite.	Polysaccharides	52-66	citrate synthase	Homo sapiens	10-12
34396759-0	2021	(Effect of polysaccharides from seeds of Vaccaria segetalis in alleviating urinary tract infection induced bladder injury by inhibiting NLRP3 inflammasome).	Polysaccharides	11-26	NLR family, pyrin domain containing 3	Rattus norvegicus	136-141
34396759-1	2021	To study the mechanism of polysaccharides from seeds of Vaccaria segetalis( PSV) in the treatment of bacterial cystitis through the NLRP3 inflammasome pathway.	Polysaccharides	26-41	NLR family, pyrin domain containing 3	Rattus norvegicus	132-137
34202416-0	2021	Feasibility Assessment of Parathyroid Hormone Adsorption by Using Polysaccharide-Based Multilayer Film Systems.	Polysaccharides	66-80	parathyroid hormone	Homo sapiens	26-45
34202570-7	2021	The important PRR, mannan binding lectin (MBL), mediates DENV neutralization through (1) a complement activation-independent mechanism via direct MBL glycan recognition, thereby inhibiting DENV attachment to host target cells, or (2) a complement activation-dependent mechanism following the attachment of complement opsonins C3b and C4b to virion surfaces.	Polysaccharides	150-156	nectin cell adhesion molecule 1	Homo sapiens	14-17
34202570-7	2021	The important PRR, mannan binding lectin (MBL), mediates DENV neutralization through (1) a complement activation-independent mechanism via direct MBL glycan recognition, thereby inhibiting DENV attachment to host target cells, or (2) a complement activation-dependent mechanism following the attachment of complement opsonins C3b and C4b to virion surfaces.	Polysaccharides	150-156	mannose binding lectin 2	Homo sapiens	19-40
34202570-7	2021	The important PRR, mannan binding lectin (MBL), mediates DENV neutralization through (1) a complement activation-independent mechanism via direct MBL glycan recognition, thereby inhibiting DENV attachment to host target cells, or (2) a complement activation-dependent mechanism following the attachment of complement opsonins C3b and C4b to virion surfaces.	Polysaccharides	150-156	mannose binding lectin 2	Homo sapiens	42-45
34202570-7	2021	The important PRR, mannan binding lectin (MBL), mediates DENV neutralization through (1) a complement activation-independent mechanism via direct MBL glycan recognition, thereby inhibiting DENV attachment to host target cells, or (2) a complement activation-dependent mechanism following the attachment of complement opsonins C3b and C4b to virion surfaces.	Polysaccharides	150-156	mannose binding lectin 2	Homo sapiens	146-149
34127673-4	2021	MGCP, in contrast to previously identified microbial cell surface polysaccharides, through a Dectin1-Cox2 signaling axis in dendritic cells, facilitates regulatory T (Treg) cell induction from naive T cells.	Polysaccharides	66-81	cytochrome c oxidase subunit 2	Saccharomyces cerevisiae S288C	101-105
34096703-2	2021	Multivalency, with several glycans binding to several binding pockets in the CBP, is important for high-affinity interactions.	Polysaccharides	27-34	CREB binding protein	Homo sapiens	77-80
34211961-2	2021	Many studies had indicated that glycans might mediate the expression and functions of fibronectin, yet a comprehensive understanding of its glycosylation is still missing.	Polysaccharides	32-39	fibronectin 1	Homo sapiens	86-97
34127709-0	2021	Glycan reactive anti-HIV-1 antibodies bind the SARS-CoV-2 spike protein but do not block viral entry.	Polysaccharides	0-6	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	58-63
34195422-6	2021	On the other hand, when CMI was evaluated, the presence of CRM197-specific IL-5 and IL-2 producing cells was evident in splenocytes from mice immunized with the full dose, while in those immunized with the fractional booster dose, IFN-gamma producing cells responsive to both protein and polysaccharide antigens were significantly increased, whereas the number of IL-5 and IL-2 positive cells remained unaffected.	Polysaccharides	288-302	interferon gamma	Mus musculus	231-240
34127709-2	2021	A common feature amongst enveloped viruses such as SARS-CoV-2 and HIV-1 is the propensity for displaying host-derived glycans on entry spike proteins.	Polysaccharides	118-125	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	135-140
34127709-6	2021	Nevertheless, ELISA and other immunoreactivity experiments demonstrate these antibodies are capable of binding the SARS-CoV-2 spike in a glycan-dependent manner.	Polysaccharides	137-143	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	126-131
34116654-4	2021	Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and other members of C-type lectin family (L-SIGN, LSECtin, CLEC10A) have been reported to interact with viral glycans to facilitate virus spreading and exacerbates inflammatory reactions.	Polysaccharides	201-208	C-type lectin domain family 4 member G	Homo sapiens	141-148
34116654-4	2021	Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) and other members of C-type lectin family (L-SIGN, LSECtin, CLEC10A) have been reported to interact with viral glycans to facilitate virus spreading and exacerbates inflammatory reactions.	Polysaccharides	201-208	C-type lectin domain containing 10A	Homo sapiens	150-157
34365448-6	2021	In this work, we examine the method of bromelain"s chemical modification with a water-soluble, biocompatible and biodegradable natural polysaccharide - dextran, oxidized to dextran aldehyde.	Polysaccharides	135-149	TATA-binding protein-associated factor 2N-like	Ananas comosus	39-48
34117223-5	2021	A total of 83 O-GalNAc glycans presenting various natural glycan epitopes are obtained and used to generate a unique synthetic mucin O-glycan microarray.	Polysaccharides	58-64	LOC100508689	Homo sapiens	127-132
34065194-3	2021	To lower the blood glucose level, various drugs are employed that block the activity of the alpha-glucosidase enzyme, which&nbsp;is considered responsible for the breakdown of polysaccharides into monosaccharides leading to an increase in the intestinal blood glucose level.	Polysaccharides	176-191	sucrase-isomaltase	Homo sapiens	92-109
34071638-2	2021	The purpose of this study was to investigate the prebiotic activities of a novel polysaccharide fraction from the Nelumbo nucifera lotus plumule, and to examine its regulation of glucose metabolism in insulin-resistant HepG2 cells.	Polysaccharides	81-95	insulin	Homo sapiens	201-208
34109226-6	2021	Hazard ratios for these lectins (+1 SD for the glycan index) were UDA (recognizing glycan: mixture of Man5 to Man9): 1.78 (95% CI: 1.24-2.55, P = 0.002) and Calsepa (High-Man (Man2-6)): 1.56 (1.19-2.04, P = 0.001).	Polysaccharides	83-89	mannosidase alpha class 1A member 1	Homo sapiens	110-114
34069226-3	2021	Human IgG antibodies lacking the core fucose in this glycan have enhanced binding to human (FcgammaR) IIIa/b, resulting in enhanced antibody dependent cell cytotoxicity and phagocytosis through these receptors.	Polysaccharides	53-59	Fc gamma receptor IIIa	Homo sapiens	91-108
34067878-0	2021	Exploring the Role of Glycans in the Interaction of SARS-CoV-2 RBD and Human Receptor ACE2.	Polysaccharides	22-29	angiotensin converting enzyme 2	Homo sapiens	86-90
34067878-10	2021	Furthermore, our simulations reveal how the glycan on Asn90 of ACE2 can play a distinct role in the binding and unbinding of RBD.	Polysaccharides	44-50	angiotensin converting enzyme 2	Homo sapiens	63-67
34069226-7	2021	Afucosylated human IgG1 showed stronger interaction with the murine FcgammaRIV, the mouse orthologue of human FcgammaRIIIa, indicating that this glycan change is functionally conserved between the species.	Polysaccharides	145-151	Fc receptor, IgG, low affinity IV	Mus musculus	68-78
34069226-7	2021	Afucosylated human IgG1 showed stronger interaction with the murine FcgammaRIV, the mouse orthologue of human FcgammaRIIIa, indicating that this glycan change is functionally conserved between the species.	Polysaccharides	145-151	Fc gamma receptor IIIa	Homo sapiens	110-122
34275842-4	2021	Compared with model groups mice, Phaeoporus obliquus polysaccharide treatment at the doses of 100mg/kg and 200mg/kg exhibited an obvious reduction liver index, ALP, ALT, AST levels, MDA content and TNF-alpha level (p<0.01) and SOD activity was increased, which was in a dose-dependent manner.	Polysaccharides	53-67	glutamic pyruvic transaminase, soluble	Mus musculus	165-168
34066520-8	2021	In addition, loss of SYS1 inhibited the biosynthesis of protein glycans, deformed the Golgi apparatus, and perturbed the localization of trans-Golgi network protein (TGN) 46.	Polysaccharides	64-71	protein SYS1 homolog	Chlorocebus sabaeus	21-25
34066520-9	2021	These results indicate that the human CRISPR KO library is applicable to Vero cell lines, and SYS1 has a widespread effect on glycan biosynthesis via regulation of intra-Golgi and endosome-TGN retrograde transports.	Polysaccharides	126-132	protein SYS1 homolog	Chlorocebus sabaeus	94-98
34275842-4	2021	Compared with model groups mice, Phaeoporus obliquus polysaccharide treatment at the doses of 100mg/kg and 200mg/kg exhibited an obvious reduction liver index, ALP, ALT, AST levels, MDA content and TNF-alpha level (p<0.01) and SOD activity was increased, which was in a dose-dependent manner.	Polysaccharides	53-67	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	170-173
34275842-4	2021	Compared with model groups mice, Phaeoporus obliquus polysaccharide treatment at the doses of 100mg/kg and 200mg/kg exhibited an obvious reduction liver index, ALP, ALT, AST levels, MDA content and TNF-alpha level (p<0.01) and SOD activity was increased, which was in a dose-dependent manner.	Polysaccharides	53-67	tumor necrosis factor	Mus musculus	198-207
34687019-6	2021	All forms of IgA are glycosylated, and the glycans significantly influence its various roles, including antigen binding and the antibody effector functions, mediated by the Fab and Fc portions, respectively.	Polysaccharides	43-50	FA complementation group B	Homo sapiens	173-176
34495539-5	2021	Modification of SARS-CoV-2 envelope membrane with glycans is important in host immune recognition and interaction between S and ACE2 glycoproteins.	Polysaccharides	50-57	angiotensin converting enzyme 2	Homo sapiens	128-132
34521318-1	2021	Helianthus Annuus L. (HAL) is composed of flavonoids and polysaccharides.	Polysaccharides	57-72	histidine ammonia lyase	Mus musculus	22-25
34375515-8	2021	Interestingly, the polysaccharide extract exerted a remarkable inhibitory effect on the receptor-interacting protein kinase RIPK1-RIPK3-MLKL (mixed lineage kinase domain-like pseudokinase) necroptosis signaling cascade, which resulted in a decreased level of phosphorylated MLKL in the colon of mice with colitis.	Polysaccharides	19-33	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	124-129
34472402-0	2021	RETRACTION NOTICE: Astragalus polysaccharide alleviates LPS-induced inflammation injury by regulating miR-127 in H9c2 cardiomyoblasts.	Polysaccharides	30-44	microRNA 127	Homo sapiens	102-109
34375515-8	2021	Interestingly, the polysaccharide extract exerted a remarkable inhibitory effect on the receptor-interacting protein kinase RIPK1-RIPK3-MLKL (mixed lineage kinase domain-like pseudokinase) necroptosis signaling cascade, which resulted in a decreased level of phosphorylated MLKL in the colon of mice with colitis.	Polysaccharides	19-33	receptor-interacting serine-threonine kinase 3	Mus musculus	130-135
34375515-8	2021	Interestingly, the polysaccharide extract exerted a remarkable inhibitory effect on the receptor-interacting protein kinase RIPK1-RIPK3-MLKL (mixed lineage kinase domain-like pseudokinase) necroptosis signaling cascade, which resulted in a decreased level of phosphorylated MLKL in the colon of mice with colitis.	Polysaccharides	19-33	mixed lineage kinase domain-like	Mus musculus	136-140
34375515-8	2021	Interestingly, the polysaccharide extract exerted a remarkable inhibitory effect on the receptor-interacting protein kinase RIPK1-RIPK3-MLKL (mixed lineage kinase domain-like pseudokinase) necroptosis signaling cascade, which resulted in a decreased level of phosphorylated MLKL in the colon of mice with colitis.	Polysaccharides	19-33	mixed lineage kinase domain-like	Mus musculus	274-278
35219153-4	2022	Interfacial interaction of albumins and hyaluronic acid reveals that human albumin presents limited conformational changes upon adsorption, which increase by complexation with the polysaccharide present at the interface.	Polysaccharides	180-194	albumin	Homo sapiens	75-82
34352784-0	2021	Astragalus Polysaccharide Regulates miR-182/Bcl-2 Axis to Relieve Metabolic Memory through Suppressing Mitochondrial Damage-Mediated Apoptosis in Retinal Pigment Epithelial Cells.	Polysaccharides	11-25	microRNA 182	Homo sapiens	36-43
34352784-0	2021	Astragalus Polysaccharide Regulates miR-182/Bcl-2 Axis to Relieve Metabolic Memory through Suppressing Mitochondrial Damage-Mediated Apoptosis in Retinal Pigment Epithelial Cells.	Polysaccharides	11-25	BCL2 apoptosis regulator	Homo sapiens	44-49
35483833-8	2022	Mechanism study demonstrates that this polysaccharide may target both BMPRIA and BMPRII to block BMP/Smad/Id1 signaling and attenuate VEGF and its transcription factor.	Polysaccharides	39-53	bone morphogenetic protein receptor type 2	Homo sapiens	81-87
35483833-8	2022	Mechanism study demonstrates that this polysaccharide may target both BMPRIA and BMPRII to block BMP/Smad/Id1 signaling and attenuate VEGF and its transcription factor.	Polysaccharides	39-53	bone morphogenetic protein 2	Homo sapiens	97-100
35483833-8	2022	Mechanism study demonstrates that this polysaccharide may target both BMPRIA and BMPRII to block BMP/Smad/Id1 signaling and attenuate VEGF and its transcription factor.	Polysaccharides	39-53	inhibitor of DNA binding 1, HLH protein	Homo sapiens	106-109
35483833-8	2022	Mechanism study demonstrates that this polysaccharide may target both BMPRIA and BMPRII to block BMP/Smad/Id1 signaling and attenuate VEGF and its transcription factor.	Polysaccharides	39-53	vascular endothelial growth factor A	Homo sapiens	134-138
35390363-6	2022	It is suggested that Pb(II)-enriched PVC exposure reduced productivities of polysaccharides and proteins in extracellular polymeric substances, which restricted the formation of microbial biofilms.	Polysaccharides	76-91	submaxillary gland androgen regulated protein 3B	Homo sapiens	21-27
35500441-6	2022	In vitro assays revealed that EDEM3 can convert an asparagine-linked M9 glycan to M8 and M7 glycans in contrast to glycine-linked M9 glycan, and the activity is enhanced in the presence of ERp46, a known partner protein of EDEM3.	Polysaccharides	72-78	ER degradation enhancing alpha-mannosidase like protein 3	Homo sapiens	30-35
35500441-0	2022	In vitro mannosidase activity of EDEM3 against asparagine-linked oligomannose-type glycans.	Polysaccharides	83-90	ER degradation enhancing alpha-mannosidase like protein 3	Homo sapiens	33-38
35500441-6	2022	In vitro assays revealed that EDEM3 can convert an asparagine-linked M9 glycan to M8 and M7 glycans in contrast to glycine-linked M9 glycan, and the activity is enhanced in the presence of ERp46, a known partner protein of EDEM3.	Polysaccharides	72-78	thioredoxin domain containing 5	Homo sapiens	189-194
35500441-5	2022	Here, we performed the biochemical characterization of EDEM3 using synthetic oligomannose-type glycan substrates.	Polysaccharides	95-101	ER degradation enhancing alpha-mannosidase like protein 3	Homo sapiens	55-60
35500441-6	2022	In vitro assays revealed that EDEM3 can convert an asparagine-linked M9 glycan to M8 and M7 glycans in contrast to glycine-linked M9 glycan, and the activity is enhanced in the presence of ERp46, a known partner protein of EDEM3.	Polysaccharides	72-78	ER degradation enhancing alpha-mannosidase like protein 3	Homo sapiens	223-228
35500441-6	2022	In vitro assays revealed that EDEM3 can convert an asparagine-linked M9 glycan to M8 and M7 glycans in contrast to glycine-linked M9 glycan, and the activity is enhanced in the presence of ERp46, a known partner protein of EDEM3.	Polysaccharides	92-99	ER degradation enhancing alpha-mannosidase like protein 3	Homo sapiens	30-35
35500441-6	2022	In vitro assays revealed that EDEM3 can convert an asparagine-linked M9 glycan to M8 and M7 glycans in contrast to glycine-linked M9 glycan, and the activity is enhanced in the presence of ERp46, a known partner protein of EDEM3.	Polysaccharides	92-99	thioredoxin domain containing 5	Homo sapiens	189-194
35500441-6	2022	In vitro assays revealed that EDEM3 can convert an asparagine-linked M9 glycan to M8 and M7 glycans in contrast to glycine-linked M9 glycan, and the activity is enhanced in the presence of ERp46, a known partner protein of EDEM3.	Polysaccharides	92-99	ER degradation enhancing alpha-mannosidase like protein 3	Homo sapiens	223-228
35500441-6	2022	In vitro assays revealed that EDEM3 can convert an asparagine-linked M9 glycan to M8 and M7 glycans in contrast to glycine-linked M9 glycan, and the activity is enhanced in the presence of ERp46, a known partner protein of EDEM3.	Polysaccharides	133-139	ER degradation enhancing alpha-mannosidase like protein 3	Homo sapiens	30-35
35583118-4	2022	As the proteins approached, the glycan of ACE2 first established a hydrogen bond with the RBD.	Polysaccharides	32-38	angiotensin converting enzyme 2	Homo sapiens	42-46
35388920-1	2022	The direct separation of dipeptidyl peptidase IV (DPP-4) inhibitors such as Sitagliptin (STG), Linagliptin (LIG), and Saxagliptin (SAG) enantiomers in normal phase conditions have been achieved on immobilized polysaccharide-based chiral stationary phases (CSPs), as well as on the macrocyclic glycopeptide vancomycin chiral stationary phase (Chirobiotic V2) under polar ionic mode.	Polysaccharides	209-223	dipeptidyl peptidase 4	Homo sapiens	25-48
35388920-1	2022	The direct separation of dipeptidyl peptidase IV (DPP-4) inhibitors such as Sitagliptin (STG), Linagliptin (LIG), and Saxagliptin (SAG) enantiomers in normal phase conditions have been achieved on immobilized polysaccharide-based chiral stationary phases (CSPs), as well as on the macrocyclic glycopeptide vancomycin chiral stationary phase (Chirobiotic V2) under polar ionic mode.	Polysaccharides	209-223	dipeptidyl peptidase 4	Homo sapiens	50-55
35331694-1	2022	Sialylated and core-fucosylated N-glycans in human transferrin (HTF) are used as glycan biomarkers due to their increased or decreased characteristics in certain diseases.	Polysaccharides	81-87	transferrin	Homo sapiens	51-62
35290457-3	2022	To extend our view of the specificity and variety of the glycan modification, we conducted a comprehensive analysis of O-GlcNAc glycans on NOTCH1 in mammals.	Polysaccharides	57-63	notch receptor 1	Homo sapiens	139-145
35536554-4	2022	The low diagnostic sensitivity of AFP led researchers to focus on AFP-L3, which has the same sequence as conventional AFP but contains a fucosylated glycan.	Polysaccharides	149-155	alpha fetoprotein	Homo sapiens	66-69
35578904-4	2022	On the basis of this bimetallic microreactor, heparosan disaccharide, oligosaccharide, and polysaccharide are successfully prepared in quantitative yield, providing a viable BMOM-based immobilization strategy to simulate the physiological microenvironment for glycosyltransferase.	Polysaccharides	91-105	glycosyltransferase family 9 protein	Pasteurella multocida	260-279
35616904-7	2022	As we reported in human spermatozoa, heavy fucosylation (fucose residues >=6 per glycan) was also detected on seminal plasma glycoproteins such as clusterin and galectin-3-binding protein, which were involved in the immune response of biological processes and reactome pathways.	Polysaccharides	81-87	galectin 3 binding protein	Homo sapiens	161-187
35393691-3	2022	Previous experimental studies found that CS combined with LPS could induce liver injury in layer chickens, and polysaccharides from charred Angelica Sinensis (CASP) had a better hepatoprotective effect than polysaccharides from unprocessed Angelica Sinensis (UASP).	Polysaccharides	111-126	cartilage associated protein	Gallus gallus	159-163
35487177-1	2022	For the functional analysis of mucin related glycan, we synthesized core 3 and 5 structures of mucin type O-glycan and investigated their binding interaction with lectins using sugar chip technology.	Polysaccharides	45-51	LOC100508689	Homo sapiens	31-36
35487177-1	2022	For the functional analysis of mucin related glycan, we synthesized core 3 and 5 structures of mucin type O-glycan and investigated their binding interaction with lectins using sugar chip technology.	Polysaccharides	45-51	LOC100508689	Homo sapiens	95-100
35513511-4	2022	N-pentynylacetylglucosamine (GlcNAl) serves as a bumped analog of N-acetylglucosamine (GlcNAc) that is specifically incorporated into glycans of cells expressing a UDP-GlcNAc pyrophosphorylase mutant, AGX2F383G.	Polysaccharides	134-141	UDP-N-acetylglucosamine pyrophosphorylase 1	Mus musculus	201-205
35513511-6	2022	By generating a transgenic mouse line with AGX2F383G expressed under a cardiomyocyte-specific promoter, we performed specific imaging of cardiomyocyte glycans in the heart and identified 582 cardiomyocyte O-GlcNAcylated proteins with no interference from other cardiac cell types.	Polysaccharides	151-158	UDP-N-acetylglucosamine pyrophosphorylase 1	Mus musculus	43-47
35093378-7	2022	The open literature reports that spent adsorbents based on polysaccharides with iron oxides may adsorb up to 1 g g-1 of organic pollutants and up to near 100% of metallic ions from wastewater (Cu2+, Cd2+, Zn2+, Pb2+).	Polysaccharides	59-74	CD2 molecule	Homo sapiens	199-202
35378162-5	2022	This study aimed to determine the antinociceptive and anti-inflammatory potential of CiL-1 in adult zebrafish by modulation of TRPA1 through lectin-glycan binding.	Polysaccharides	148-154	transient receptor potential cation channel, subfamily A, member 1a	Danio rerio	127-132
35378162-13	2022	Based on the predictions made for the oligosaccharides, a tetra-antenate putative glycan was schematically constructed, illustrating an interaction between TRPA1 N-glycan and CiL-1.	Polysaccharides	82-88	transient receptor potential cation channel, subfamily A, member 1a	Danio rerio	156-161
35580208-2	2022	Here, a highly stretchable, sensitive, and multifunctional polysaccharide-based dual-network hydrogel sensor was constructed using dialdehyde carboxymethyl cellulose (DCMC), chitosan (CS), poly(acrylic acid) (PAA), and aluminum ions (Al3+).	Polysaccharides	59-73	citrate synthase	Homo sapiens	184-186
35352215-2	2022	The high incidence of glycan-rich components within altered ECM makes the use of glycan-binding proteins such as Galectin-3 (G3) a promising therapeutic strategy.	Polysaccharides	22-28	galectin 3	Homo sapiens	113-123
35617912-5	2022	But the mannose receptor is just one of many glycan-binding proteins expressed in macrophages, leading to an interest in the potential relationship between the macrophage glycome and how it may regulate cognate glycan-binding protein activities.	Polysaccharides	45-51	mannose receptor C-type 1	Homo sapiens	8-24
35603428-2	2022	The core glycan of GPI precursor has three mannoses, which in mammals, are all modified by ethanolamine-phosphate (EthN-P).	Polysaccharides	9-15	glucose-6-phosphate isomerase	Homo sapiens	19-22
35617912-5	2022	But the mannose receptor is just one of many glycan-binding proteins expressed in macrophages, leading to an interest in the potential relationship between the macrophage glycome and how it may regulate cognate glycan-binding protein activities.	Polysaccharides	211-217	mannose receptor C-type 1	Homo sapiens	8-24
35434540-3	2022	Both, virus and ACE2, are highly glycosylated, and exploiting glycans of the SARS-CoV-2 envelope as binding sites for ACE2 represents a virus strategy for attacking the human host.	Polysaccharides	62-69	angiotensin converting enzyme 2	Homo sapiens	16-20
35420777-1	2022	Heparan sulfate (HS) and chondroitin sulfate (CS) are two structurally distinct natural polysaccharides.	Polysaccharides	88-103	citrate synthase	Homo sapiens	46-48
35420777-7	2022	Our findings demonstrate the synthesis of unnatural HS-CS chimeric oligosaccharides using natural biosynthetic enzymes, offering a new class of glycan molecules for biological research.	Polysaccharides	144-150	citrate synthase	Homo sapiens	55-57
35446786-8	2022	Aptamer-based results point to enzymes writing glycan marks present on uromodulin and to their receptors in the circulation, suggesting that this assay permits investigating uromodulin"s complex glycosylation rather than its quantitative levels.	Polysaccharides	47-53	uromodulin	Homo sapiens	71-81
35446786-8	2022	Aptamer-based results point to enzymes writing glycan marks present on uromodulin and to their receptors in the circulation, suggesting that this assay permits investigating uromodulin"s complex glycosylation rather than its quantitative levels.	Polysaccharides	47-53	uromodulin	Homo sapiens	174-184
35434540-3	2022	Both, virus and ACE2, are highly glycosylated, and exploiting glycans of the SARS-CoV-2 envelope as binding sites for ACE2 represents a virus strategy for attacking the human host.	Polysaccharides	62-69	angiotensin converting enzyme 2	Homo sapiens	118-122
35499339-1	2022	Human intelectin-1 (hIntL-1) is a secreted glycoprotein capable of binding exocyclic 1,2-diols within surface glycans of human pathogens such as Streptococcus pneumoniae, Vibrio cholerae, and Helicobacter pylori.	Polysaccharides	110-117	intelectin 1	Homo sapiens	6-18
35621986-1	2022	Chitosan (CS) is a linear polysaccharide obtained by the deacetylation of chitin, which, after cellulose, is the second biopolymer most abundant in nature, being the primary component of the exoskeleton of crustaceans and insects.	Polysaccharides	26-40	citrate synthase	Homo sapiens	0-8
35621986-1	2022	Chitosan (CS) is a linear polysaccharide obtained by the deacetylation of chitin, which, after cellulose, is the second biopolymer most abundant in nature, being the primary component of the exoskeleton of crustaceans and insects.	Polysaccharides	26-40	citrate synthase	Homo sapiens	10-12
35437982-7	2022	This method for extracellular addition of alpha2-6-linked SiaDAz enables UV-induced crosslinking of CD22, demonstrating the utility for covalent capture of glycan-mediated binding interactions.	Polysaccharides	156-162	immunoglobulin kappa variable 6-21 (non-functional)	Homo sapiens	42-50
35631269-2	2022	In this study, the ability to regulate the production of IL-8 of the water-soluble non-starch polysaccharide (WS-NSP) from taro corm (Tc-WS-NSP) extracted using a conventional (CE) or improved conventional (ICE) extraction method, of the probiotics Lactobacillus acidophilus, Bifidobacterium breve, and Bifidobacterium infantis, and their synbiotic mixtures were evaluated.	Polysaccharides	94-108	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
35437982-7	2022	This method for extracellular addition of alpha2-6-linked SiaDAz enables UV-induced crosslinking of CD22, demonstrating the utility for covalent capture of glycan-mediated binding interactions.	Polysaccharides	156-162	CD22 molecule	Homo sapiens	100-104
35470665-1	2022	Dense glycosylation and the trimeric conformation of the human immunodeficiency virus-1 (HIV-1) envelope protein limit the accessibility of some cellular glycan processing enzymes and end up with high-mannose-type N-linked glycans on the envelope spike, among which the Man5GlcNAc2 structure occupies a certain proportion.	Polysaccharides	154-160	endogenous retrovirus group K member 6, envelope	Homo sapiens	96-112
35470665-8	2022	These results demonstrated that the immune tolerance mechanism suppressed the immune responses to Man5-related structures and the conformation of glycan epitopes on the synthesized glycoconjugates was distinct from that of native glycan epitopes on gp120.	Polysaccharides	146-152	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	249-254
35470665-8	2022	These results demonstrated that the immune tolerance mechanism suppressed the immune responses to Man5-related structures and the conformation of glycan epitopes on the synthesized glycoconjugates was distinct from that of native glycan epitopes on gp120.	Polysaccharides	230-236	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	249-254
35594938-1	2022	To explore the active polysaccharides from Dendrobium devonianum, a novel O-acetylmannan (DDP-1) with molecular weight of 117 kDa was isolated from D. devonianum.	Polysaccharides	22-37	translocase of inner mitochondrial membrane 8A	Homo sapiens	90-95
35627036-4	2022	polysaccharide (ACP) has many important biological activities and has potential application value in food engineering, pharmaceutical science, and health care.	Polysaccharides	0-14	vitamin A enhanced cleft palate	Mus musculus	16-19
35588979-1	2022	A novel polysaccharide (MSP-1) was isolated from the fruiting body of Morchella sextelata and purified using DEAE-52 and Sephadex G-75.	Polysaccharides	8-22	salivary protein electrophoretic 1, regulator	Mus musculus	24-29
35562647-10	2022	Lectibodies can lead to neutralization and clearance of viruses and cells infected by viruses by binding to glycans located on the envelope surface (e.g., the heavily glycosylated SARS-CoV-2 spike protein).	Polysaccharides	108-115	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	191-196
35346678-1	2022	One galactose- and arabinose-rich polysaccharide isolated from Sambucus adnata was named SPS-1, which had an average molecular weight 138.52 kDa, and was composed of L-rhamnose, D-glucuronic acid, D-galacturonic acid, D-galactose, and L-arabinose in a molar ratio of 0.6:0.4:0.1:4.9:4.0.	Polysaccharides	34-48	selenophosphate synthetase 1	Mus musculus	89-94
34740281-2	2022	For photodissociation MS, infrared (IR) and ultraviolet (UV) lasers can generate complementary fragment ions, so an effective combination of the two methods may provide rich and valuable fragment patterns for glycan analysis.	Polysaccharides	209-215	insulin receptor	Homo sapiens	36-38
34740281-8	2022	CONCLUSIONS: This study demonstrates the capabilities of the combination of IR and UV photodissociation MS in the identification of diverse glycan isomers.	Polysaccharides	140-146	insulin receptor	Homo sapiens	76-78
35439019-9	2022	The use of CS in combination with Thy sequences in brush-like structures on CS is a model for other polysaccharides to be conjugated with the as-designed nucleic acid sequences for potential gene delivery.	Polysaccharides	100-115	citrate synthase	Homo sapiens	76-78
35633685-0	2022	Influence of the Polysaccharide Capsule on the Bactericidal Activity of Indolicidin on Streptococcus pneumoniae.	Polysaccharides	17-31	cathelicidin-4	Bos taurus	72-83
35626964-1	2022	In this study, a system was designed that can encapsulate and deliver gallic acid (GA), which was composed of polysaccharide polymers based on sodium alginate (SA), carboxymethyl chitosan (CCT), and cellulose nanofibers (CN) and was assisted by porous starch.	Polysaccharides	110-124	CCT	Homo sapiens	189-192
35247653-0	2022	Characterizing a novel hyposialylated erythropoietin by intact glycoprotein and glycan analysis.	Polysaccharides	80-86	erythropoietin	Homo sapiens	38-52
35559953-7	2022	We identified 79 N-glycopeptides from 15 different proteins and found that proteins including immunoglobulin A1, polymeric immunoglobulin receptor, and lactotransferrin displayed significant glycan heterogeneity.	Polysaccharides	191-197	megakaryocyte and platelet inhibitory receptor G6b	Homo sapiens	123-146
35559953-7	2022	We identified 79 N-glycopeptides from 15 different proteins and found that proteins including immunoglobulin A1, polymeric immunoglobulin receptor, and lactotransferrin displayed significant glycan heterogeneity.	Polysaccharides	191-197	lactotransferrin	Homo sapiens	152-168
35439019-9	2022	The use of CS in combination with Thy sequences in brush-like structures on CS is a model for other polysaccharides to be conjugated with the as-designed nucleic acid sequences for potential gene delivery.	Polysaccharides	100-115	citrate synthase	Homo sapiens	11-13
35513489-4	2022	This fold with a beta-sheet clasping an alpha-helix represents a new fold for glycan recognition based on glycan array screening, which shows that VP8*B recognizes glycans containing N-acetyllactosamine moiety.	Polysaccharides	78-84	amyloid beta precursor protein	Homo sapiens	15-21
35527362-12	2022	DG-SDH formulated at a ratio of 3:2 (DG-SDH (3:2)) produced the highest content of polysaccharides, polyphenols, and flavonoids.	Polysaccharides	83-98	serine dehydratase	Homo sapiens	3-6
35527362-12	2022	DG-SDH formulated at a ratio of 3:2 (DG-SDH (3:2)) produced the highest content of polysaccharides, polyphenols, and flavonoids.	Polysaccharides	83-98	serine dehydratase	Homo sapiens	40-43
35536497-7	2022	The biological effects of the extracted polysaccharides from Ganoderma lucidum and Lentinula edodes on the MCF-7 cell line were investigated using an MTT assay and then its effects on the expression of the P53 cancer regulatory gene and HER-3 gene were investigated.	Polysaccharides	40-55	tumor protein p53	Homo sapiens	206-209
35536497-7	2022	The biological effects of the extracted polysaccharides from Ganoderma lucidum and Lentinula edodes on the MCF-7 cell line were investigated using an MTT assay and then its effects on the expression of the P53 cancer regulatory gene and HER-3 gene were investigated.	Polysaccharides	40-55	erb-b2 receptor tyrosine kinase 3	Homo sapiens	237-242
35536497-9	2022	Polysaccharides of these two fungi increased the expression of the P53 gene and decreased the expression of the HER-3 gene in a dose and time-dependent manner.	Polysaccharides	0-15	tumor protein p53	Homo sapiens	67-70
35536497-9	2022	Polysaccharides of these two fungi increased the expression of the P53 gene and decreased the expression of the HER-3 gene in a dose and time-dependent manner.	Polysaccharides	0-15	erb-b2 receptor tyrosine kinase 3	Homo sapiens	112-117
35513489-4	2022	This fold with a beta-sheet clasping an alpha-helix represents a new fold for glycan recognition based on glycan array screening, which shows that VP8*B recognizes glycans containing N-acetyllactosamine moiety.	Polysaccharides	106-112	amyloid beta precursor protein	Homo sapiens	15-21
35513489-4	2022	This fold with a beta-sheet clasping an alpha-helix represents a new fold for glycan recognition based on glycan array screening, which shows that VP8*B recognizes glycans containing N-acetyllactosamine moiety.	Polysaccharides	164-171	amyloid beta precursor protein	Homo sapiens	15-21
35603205-0	2022	Homogeneous Polyporus Polysaccharide Inhibit Bladder Cancer by Resetting Tumor-Associated Macrophages Toward M1 Through NF-kappaB/NLRP3 Signaling.	Polysaccharides	22-36	NLR family, pyrin domain containing 3	Rattus norvegicus	130-135
35333306-0	2022	The Mnn10/Anp1-dependent N-linked outer chain glycan is dispensable for Candida albicans cell wall integrity.	Polysaccharides	46-52	alpha-1,6-mannosyltransferase	Saccharomyces cerevisiae S288C	4-9
35333306-0	2022	The Mnn10/Anp1-dependent N-linked outer chain glycan is dispensable for Candida albicans cell wall integrity.	Polysaccharides	46-52	Anp1p	Saccharomyces cerevisiae S288C	10-14
35332581-4	2022	Herein, we rationally developed a nanoparticle vaccine, termed SCTV01B, by using the capsular polysaccharide of S. pneumoniae serotype 14 (PPS14) as the backbone to conjugate with the recombinant receptor binding domain (RBD) of the SARS-CoV-2 spike protein.	Polysaccharides	94-108	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	244-249
35508142-4	2022	Moreover, we also show that a GPI-AP with a C26 ceramide moiety is monitored by the GPI-glycan remodelase Ted1, which, in turn, is required for receptor-mediated export of GPI-APs.	Polysaccharides	88-94	Ted1p	Saccharomyces cerevisiae S288C	106-110
35600398-5	2022	Here we utilized an array of glycosylation defective cell lines to further define the PODO447 reactive epitope and reveal it as an O-linked core 1 glycan presented in the context of the Podxl peptide backbone.	Polysaccharides	147-153	podocalyxin like	Homo sapiens	186-191
35586194-7	2022	The cysteine-cysteine loops and the two diversity loops (DL1 and DL2) were identified to play an essential role in recognizing the glycan molecule.	Polysaccharides	131-137	delta like canonical Notch ligand 1	Homo sapiens	57-60
35176320-0	2022	Gardenia jasminoides Ellis polysaccharide ameliorates cholestatic liver injury by alleviating gut microbiota dysbiosis and inhibiting the TLR4/NF-kappaB signaling pathway.	Polysaccharides	27-41	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	143-152
35013926-0	2022	Comparison of Enzyme-Linked Lectin Sorbent Assay and Flow Cytometry for Profiling Microbial Glycans.	Polysaccharides	92-99	lectin	Musa acuminata	28-34
35304256-2	2022	The best dosing method after optimization was to add four parts of lysozyme at 0 h and one part of protease at 1 h. The extracellular proteins and polysaccharides increased by 118% and 64% respectively under the optimal dosing mode.	Polysaccharides	147-162	lysozyme	Homo sapiens	67-75
35563423-0	2022	Acanthopanax senticosus Polysaccharide Enhances the Pathogen Resistance of Radiation-Damaged Caenorhabditis elegans through Intestinal p38 MAPK-SKN-1/ATF-7 Pathway and Stress Response.	Polysaccharides	24-38	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	144-149
35563423-0	2022	Acanthopanax senticosus Polysaccharide Enhances the Pathogen Resistance of Radiation-Damaged Caenorhabditis elegans through Intestinal p38 MAPK-SKN-1/ATF-7 Pathway and Stress Response.	Polysaccharides	24-38	Transcription factor atf-7	Caenorhabditis elegans	150-155
32068087-4	2022	Among the plant lectins-derived glycan motifs, Man9GlcNAc2Asn exhibits high-affinity interactions with CLRs that may resemble glycan motifs of pathogens.	Polysaccharides	32-38	mannosidase alpha class 1A member 1	Homo sapiens	47-51
32068087-4	2022	Among the plant lectins-derived glycan motifs, Man9GlcNAc2Asn exhibits high-affinity interactions with CLRs that may resemble glycan motifs of pathogens.	Polysaccharides	126-132	mannosidase alpha class 1A member 1	Homo sapiens	47-51
32068087-5	2022	Thus, such glycan domains when presented along with antigens complexed with a nanocarrier of choice may bewilder the immune cells and direct antigen cross-presentation - a cytotoxic T lymphocyte immune response mediated by CD8+ T cells.	Polysaccharides	11-17	CD8a molecule	Homo sapiens	223-226
35176320-0	2022	Gardenia jasminoides Ellis polysaccharide ameliorates cholestatic liver injury by alleviating gut microbiota dysbiosis and inhibiting the TLR4/NF-kappaB signaling pathway.	Polysaccharides	27-41	toll-like receptor 4	Mus musculus	138-142
35149427-3	2022	Galalpha1-3Galbeta1-4GlcNAc-R (alpha-gal) glycan epitope is a highly immunogenic epitope exerted by the enzyme alpha1-3-galactosyltransferase (alpha1,3GT) in mammalian cells on the glycan skeleton.	Polysaccharides	181-187	BCL2 related protein A1	Homo sapiens	143-153
35400456-0	2022	Combined RNA-seq and molecular biology technology revealed the protective effect of Cyclocarya paliurus polysaccharide on H2O2-induced oxidative damage in L02 cells thought regulating mitochondrial function, oxidative stress and PI3K/Akt and MAPK signaling pathways.	Polysaccharides	104-118	AKT serine/threonine kinase 1	Homo sapiens	234-237
35488480-3	2022	Using reverse genetics, we identified IQ67 DOMAIN 9 (IQD9) and KINESIN LIGHT CHAIN-RELATED 1 (KLCR1) as two highly expressed genes during seed development and comprehensively characterized their roles in cell wall polysaccharide biosynthesis.	Polysaccharides	214-228	IQ-domain 9	Arabidopsis thaliana	53-57
35488480-3	2022	Using reverse genetics, we identified IQ67 DOMAIN 9 (IQD9) and KINESIN LIGHT CHAIN-RELATED 1 (KLCR1) as two highly expressed genes during seed development and comprehensively characterized their roles in cell wall polysaccharide biosynthesis.	Polysaccharides	214-228	Tetratricopeptide repeat (TPR)-like superfamily protein	Arabidopsis thaliana	63-92
35202634-1	2022	In this study, a novel low molecular weight polysaccharide (named LMW-BSP) was extracted from Bletilla striata at 4  C. The results of structural characteristics analysis showed that LMW-BSP was a 23 kDa neutral polysaccharide contained glucose and mannose at a molar ratio of 1.00:1.26.	Polysaccharides	44-58	black spleen	Mus musculus	70-73
35202634-1	2022	In this study, a novel low molecular weight polysaccharide (named LMW-BSP) was extracted from Bletilla striata at 4  C. The results of structural characteristics analysis showed that LMW-BSP was a 23 kDa neutral polysaccharide contained glucose and mannose at a molar ratio of 1.00:1.26.	Polysaccharides	44-58	black spleen	Mus musculus	187-190
35311893-0	2022	Glycans that regulate Notch signaling in the intestine.	Polysaccharides	0-7	notch receptor 1	Homo sapiens	22-27
35202634-1	2022	In this study, a novel low molecular weight polysaccharide (named LMW-BSP) was extracted from Bletilla striata at 4  C. The results of structural characteristics analysis showed that LMW-BSP was a 23 kDa neutral polysaccharide contained glucose and mannose at a molar ratio of 1.00:1.26.	Polysaccharides	212-226	black spleen	Mus musculus	187-190
35191576-2	2022	The NMR-based distinction between the signals of those sialic acids in the glycans covalently attached to the spike protein and those belonging to the exogenous a2,3 and a2,6 sialyl N-Acetyllactosamine ligands has been achieved by synthesizing uniformly 13C-labelled trisaccharides at the sialic acid and galactose moieties.	Polysaccharides	75-82	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	110-115
35475646-4	2022	A recent study showed that an analog of temsavir (BMS-377806) affects the cleavage and addition of complex glycans on Env.	Polysaccharides	107-114	endogenous retrovirus group K member 20	Homo sapiens	118-121
35473605-4	2022	We evaluated SHS effects in mice with and without semi-synthetic glycosaminoglycan ethers (SAGEs), which are anionic, partially lipophilic sulfated polysaccharide derivatives known to inhibit RAGE signaling.	Polysaccharides	148-162	advanced glycosylation end product-specific receptor	Mus musculus	192-196
35486871-11	2022	Mucin glycomic analysis revealed significantly more sialylated glycans in CF and the total abundance of non-sulfated O-glycans was correlated with the relative abundance of pathogens.	Polysaccharides	63-70	LOC100508689	Homo sapiens	0-5
35427125-3	2022	Due to high amino acid conservation among galectins and the shallow nature of their glycan-binding site, the design of selective potent antagonists targeting galectin-3 is challenging.	Polysaccharides	84-90	galectin 3	Homo sapiens	158-168
35343792-13	2022	We and others have found that the glycans on GPC and the F427 residue in the GPC TMD are important for virulence of JUNV.	Polysaccharides	34-41	glycoprotein precursor	Argentinian mammarenavirus	45-48
35498131-0	2022	Polysaccharides from Polygonatum cyrtonema Hua Reduce Depression-Like Behavior in Mice by Inhibiting Oxidative Stress-Calpain-1-NLRP3 Signaling Axis.	Polysaccharides	0-15	calpain 1	Mus musculus	118-127
35469905-0	2022	The psoriasis glycome: differential expression of cholesterol particle glycans and IgA glycans linked to disease severity.	Polysaccharides	87-94	CD79a molecule	Homo sapiens	83-86
35497917-0	2022	Aqueous Extract and Polysaccharide of Aconiti Lateralis Radix Induce Apoptosis and G0/G1 Phase Cell Cycle Arrest by PI3K/AKT/mTOR Signaling Pathway in Mesangial Cells.	Polysaccharides	20-34	AKT serine/threonine kinase 1	Homo sapiens	121-124
35497917-0	2022	Aqueous Extract and Polysaccharide of Aconiti Lateralis Radix Induce Apoptosis and G0/G1 Phase Cell Cycle Arrest by PI3K/AKT/mTOR Signaling Pathway in Mesangial Cells.	Polysaccharides	20-34	mechanistic target of rapamycin kinase	Homo sapiens	125-129
35380569-1	2022	The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells.	Polysaccharides	55-62	CD209 molecule	Homo sapiens	28-35
35380569-1	2022	The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells.	Polysaccharides	55-62	C-type lectin domain family 4 member M	Homo sapiens	40-46
35380569-1	2022	The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells.	Polysaccharides	55-62	angiotensin converting enzyme 2	Homo sapiens	131-135
35274759-2	2022	Here, we report that mice expressing an E3 ligase-inactive HOIL-1(C458S) mutant accumulate polyglucosan in brain, heart and other organs, indicating that HOIL-1"s E3 ligase activity is essential to prevent these toxic polysaccharide deposits from accumulating.	Polysaccharides	218-232	RanBP-type and C3HC4-type zinc finger containing 1	Mus musculus	59-65
35274759-2	2022	Here, we report that mice expressing an E3 ligase-inactive HOIL-1(C458S) mutant accumulate polyglucosan in brain, heart and other organs, indicating that HOIL-1"s E3 ligase activity is essential to prevent these toxic polysaccharide deposits from accumulating.	Polysaccharides	218-232	RanBP-type and C3HC4-type zinc finger containing 1	Mus musculus	154-160
35427432-2	2022	Heparanase (HPSE) is the sole HS degrading endoglycosidase that cleaves HS at structure-dependent sites along the polysaccharide chain.	Polysaccharides	114-128	heparanase	Mus musculus	0-10
35108598-2	2022	In the current study, the effect of Physalis alkekengi L. fruit polysaccharide (PFP) on preventing dietary AGE-induced insulin resistance (IR) in mice was investigated.	Polysaccharides	64-78	perforin 1 (pore forming protein)	Mus musculus	80-83
35563055-2	2022	In particular, the activation of pathways leading to abundant renal deposits of complement is likely to involve the binding of mannose-binding lectin (MBL) to aberrant glycans on immunoglobulins.	Polysaccharides	168-175	mannose binding lectin 2	Homo sapiens	127-149
35563055-2	2022	In particular, the activation of pathways leading to abundant renal deposits of complement is likely to involve the binding of mannose-binding lectin (MBL) to aberrant glycans on immunoglobulins.	Polysaccharides	168-175	mannose binding lectin 2	Homo sapiens	151-154
35439332-4	2022	We report on design, chemical synthesis and immunobiology of novel glycan-based lipid A-mimicking molecules that can activate human and murine TLR4-mediated signaling with picomolar affinity.	Polysaccharides	67-73	toll-like receptor 4	Mus musculus	143-147
35475171-0	2022	Distinct Core Glycan and O-Glycoform Utilization of SARS-CoV-2 Omicron Variant Spike Protein RBD Revealed by Top-Down Mass Spectrometry.	Polysaccharides	14-20	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	79-84
35495643-0	2022	Assessing the Mobility of Severe Acute Respiratory Syndrome Coronavirus-2 Spike Protein Glycans by Structural and Computational Methods.	Polysaccharides	88-95	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	74-79
35495643-3	2022	Like to many other viral fusion proteins, the SARS-CoV-2 spike protein utilizes a glycan shield to thwart the host immune response.	Polysaccharides	82-88	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	57-62
35498131-0	2022	Polysaccharides from Polygonatum cyrtonema Hua Reduce Depression-Like Behavior in Mice by Inhibiting Oxidative Stress-Calpain-1-NLRP3 Signaling Axis.	Polysaccharides	0-15	NLR family, pyrin domain containing 3	Mus musculus	128-133
35148986-6	2022	Utilization of microarrays populated with blood group O antigens from a diverse array of microbes revealed that while Gal-9 can bind various microbial glycans, Gal-9N and Gal-9C displayed distinct and overlapping binding preferences.	Polysaccharides	151-158	galectin 9	Homo sapiens	118-123
35411940-3	2022	These glycans can be recognised by mannose-binding lectins, including the mannose receptor (CD206), expressed on macrophages and specialised phagocytic endothelial cells in the spleen to mediate the extravascular haemolysis characteristic of these diseases.	Polysaccharides	6-13	mannose receptor C-type 1	Homo sapiens	92-97
35432728-12	2022	polysaccharides (ABP) was characterized by FT-IR spectrum and HPLC chromatogram.	Polysaccharides	0-15	glutamate receptor interacting protein 2	Rattus norvegicus	17-20
35406805-8	2022	An in vivo binding assay using the soluble NEGR1 protein demonstrated that glycans N286, N294 and N307 on the C-terminal immunoglobulin-like domain play important roles in homophilic interactions.	Polysaccharides	75-82	neuronal growth regulator 1	Homo sapiens	43-48
35383367-8	2022	Together, our results support a model of protein sub-functionalization where AtFH5 and AtFH3, restricted to specific plasma membrane domains by their ECDs and the glycans attached to them, organize distinct subarrays of actin during pollen tube elongation.	Polysaccharides	163-170	formin homology5	Arabidopsis thaliana	77-82
35383367-8	2022	Together, our results support a model of protein sub-functionalization where AtFH5 and AtFH3, restricted to specific plasma membrane domains by their ECDs and the glycans attached to them, organize distinct subarrays of actin during pollen tube elongation.	Polysaccharides	163-170	formin 3	Arabidopsis thaliana	87-92
35272895-0	2022	Retraction notice to "Astragalus polysaccharide ameliorates lipopolysaccharide-induced cell injury in ATDC5 cells via miR-92a/KLF4 mediation" (Biomed.	Polysaccharides	33-47	Kruppel-like factor 4 (gut)	Mus musculus	126-130
35377103-9	2022	During recognition of pathogen-specific glycans, direct association of LacCer-containing C24 fatty acid chain with Lyn (a Src family kinase) is necessary for signal transduction from the neutrophil exterior to interior.	Polysaccharides	40-47	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	115-139
35410995-7	2022	MUC21 transfection into Lec2 cells, a variant of CHO cells lacking sialylation of glycans, revealed that the presence of nonsialylated T-antigen also renders cells resistant to etoposide-induced apoptosis.	Polysaccharides	82-89	mucin-21	Cricetulus griseus	0-5
35395116-0	2022	The Cellulose Synthase-Like F3 (CslF3) Gene Mediates Cell Wall Polysaccharide Synthesis and Affects Root Growth and Differentiation in Barley.	Polysaccharides	63-77	CslF3	Hordeum vulgare	4-30
35395116-0	2022	The Cellulose Synthase-Like F3 (CslF3) Gene Mediates Cell Wall Polysaccharide Synthesis and Affects Root Growth and Differentiation in Barley.	Polysaccharides	63-77	CslF3	Hordeum vulgare	32-37
35230146-0	2022	Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models.	Polysaccharides	50-56	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	28-33
35230146-2	2022	As the key immunogen, the viral surface spike (S) protein is frequently mutated, and conserved epitopes are shielded by glycans.	Polysaccharides	120-127	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	40-45
35230146-2	2022	As the key immunogen, the viral surface spike (S) protein is frequently mutated, and conserved epitopes are shielded by glycans.	Polysaccharides	120-127	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	47-48
35377278-5	2022	Current status and trends in glycan analysis of therapeutic IgA, dominantly based on mass spectrometry and lectin microarrays are herein summarised as well.	Polysaccharides	29-35	CD79a molecule	Homo sapiens	60-63
35074118-4	2022	Derived from red seaweeds, carrageenan (CG) is a naturally-occurring polysaccharide that has shown promise as a biopolymer for various biomedical applications.	Polysaccharides	69-83	cathepsin G	Homo sapiens	40-42
35431954-0	2022	Radix Astragalus Polysaccharide Accelerates Angiogenesis by Activating AKT/eNOS to Promote Nerve Regeneration and Functional Recovery.	Polysaccharides	17-31	AKT serine/threonine kinase 1	Homo sapiens	71-74
35431954-0	2022	Radix Astragalus Polysaccharide Accelerates Angiogenesis by Activating AKT/eNOS to Promote Nerve Regeneration and Functional Recovery.	Polysaccharides	17-31	nitric oxide synthase 3	Homo sapiens	75-79
35148986-7	2022	Flow cytometric examination of intact microbes corroborated the microbial glycan microarray findings, demonstrating that Gal-9, Gal-9N, and Gal-9C also possess the capacity to recognize distinct strains of Providencia alcalifaciens and Klebsiella pneumoniae that express mammalian blood group-like antigens while failing to bind related strains that do not express mammalian-like glycans.	Polysaccharides	380-387	galectin 9	Homo sapiens	121-126
35148986-7	2022	Flow cytometric examination of intact microbes corroborated the microbial glycan microarray findings, demonstrating that Gal-9, Gal-9N, and Gal-9C also possess the capacity to recognize distinct strains of Providencia alcalifaciens and Klebsiella pneumoniae that express mammalian blood group-like antigens while failing to bind related strains that do not express mammalian-like glycans.	Polysaccharides	380-387	galectin 9C	Homo sapiens	140-146
35507105-6	2022	We found that glycan-involved hydrogen bonds and glycan-dimer occlusion were useful metrics predicting the proteolytic stability and dimerization propensity of insulin, respectively, as was in part the solvent-accessible surface area of proteolytic sites.	Polysaccharides	14-20	insulin	Homo sapiens	160-167
35507105-6	2022	We found that glycan-involved hydrogen bonds and glycan-dimer occlusion were useful metrics predicting the proteolytic stability and dimerization propensity of insulin, respectively, as was in part the solvent-accessible surface area of proteolytic sites.	Polysaccharides	49-55	insulin	Homo sapiens	160-167
35362215-5	2022	We tracked selfish polysaccharides uptake in surface microbial communities of the northeastern Mediterranean Sea, linking the occurrence of this processing mode with microbial lifestyle.	Polysaccharides	19-34	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	109-112
35534262-1	2022	This study explored whether Sagittaria sagittifolia polysaccharides(SSP) activates the nuclear factor erythroid-2-related factor2(Nrf2)/heme oxygenase-1(HO-1) signaling pathway to protect against liver damage jointly induced by multiple heavy metals.	Polysaccharides	52-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	130-134
35534262-1	2022	This study explored whether Sagittaria sagittifolia polysaccharides(SSP) activates the nuclear factor erythroid-2-related factor2(Nrf2)/heme oxygenase-1(HO-1) signaling pathway to protect against liver damage jointly induced by multiple heavy metals.	Polysaccharides	52-67	heme oxygenase 1	Mus musculus	153-157
35168327-8	2022	In conclusion, we show that GSL glycan expression levels are associated with hematopoietic AML classifications and TF and GT gene expression.	Polysaccharides	32-38	cathepsin A	Homo sapiens	28-31
35365790-1	2022	Processed foods often include food additives such as xanthan gum, a complex polysaccharide with unique rheological properties, that has established widespread use as a stabilizer and thickening agent.	Polysaccharides	76-90	OTU deubiquitinase with linear linkage specificity	Homo sapiens	61-64
35365790-2	2022	Xanthan gum"s chemical structure is distinct from those of host and dietary polysaccharides that are more commonly expected to transit the gastrointestinal tract, and little is known about its direct interaction with the gut microbiota, which plays a central role in digestion of other dietary fibre polysaccharides.	Polysaccharides	300-315	OTU deubiquitinase with linear linkage specificity	Homo sapiens	8-11
35354833-2	2022	We demonstrate that genetic alteration of the glycan heparan sulfate (HS) in CD11c + cells via Ndst1f/f CD11cCre + mutation, which inhibits HS sulfation in a major antigen presenting cell population, reduces lung inflammation by A/Puerto Rico/8/1934(H1N1) influenza in mice.	Polysaccharides	46-52	integrin subunit alpha X	Homo sapiens	77-82
35038468-7	2022	Compared with WL-CPS-1, GLU-CPS-1 exhibited higher in vivo activity and enriched Odoribacter and Alloprevotella correlating with the gene expression of lipid metabolism, suggesting that the bioactivity of polysaccharides could be regulated by culture conditions.	Polysaccharides	205-220	carbamoyl-phosphate synthetase 1	Mus musculus	28-33
35344290-0	2022	Mac-2-binding protein glycan isomer predicts all malignancies after sustained virological response in chronic hepatitis C. Despite reports of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C virus (HCV) infection after achieving sustained virological response (SVR), only few studies have demonstrated the incidence of other (non-HCC) malignancies.	Polysaccharides	22-28	galectin 3 binding protein	Homo sapiens	0-21
35302744-2	2022	To perform MS-SG, natural libraries of glycans derived from glycoconjugates in cells or tissues are screened against a target GBP using catch-and-release electrospray ionization mass spectrometry (CaR-ESI-MS).	Polysaccharides	39-46	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha	Homo sapiens	126-129
35354052-2	2022	Env is heavily glycosylated with host-derived N-glycans, and many bnAbs bind to, or are dependent upon, Env glycans for neutralization.	Polysaccharides	108-115	endogenous retrovirus group K member 20	Homo sapiens	0-3
35354052-2	2022	Env is heavily glycosylated with host-derived N-glycans, and many bnAbs bind to, or are dependent upon, Env glycans for neutralization.	Polysaccharides	108-115	endogenous retrovirus group K member 20	Homo sapiens	104-107
35447896-1	2022	An immunomodulatory polysaccharide (DAP4) was extracted, purified, and characterized from Durvillaea antarctica.	Polysaccharides	20-34	DLG associated protein 4	Mus musculus	36-40
35408512-8	2022	In conclusion, this study suggests that the flavonoids, phenolic acids and polysaccharides from chrysanthemum stem and leaf extracts can improve inflammatory bowel disease of zebrafish by regulating the expressions of IL-1beta, IL-8 and MMP9.	Polysaccharides	75-90	chemokine (C-X-C motif) ligand 8a	Danio rerio	228-232
35408512-8	2022	In conclusion, this study suggests that the flavonoids, phenolic acids and polysaccharides from chrysanthemum stem and leaf extracts can improve inflammatory bowel disease of zebrafish by regulating the expressions of IL-1beta, IL-8 and MMP9.	Polysaccharides	75-90	matrix metallopeptidase 9	Danio rerio	237-241
35401559-5	2022	By utilizing an antigen panel of point mutants within the HIV-1 Env glycoprotein, we identified and confirmed antibodies targeting multiple sites of vulnerability on Env, including the CD4-binding site and the V3-glycan site.	Polysaccharides	213-219	endogenous retrovirus group K member 20	Homo sapiens	64-67
35401559-5	2022	By utilizing an antigen panel of point mutants within the HIV-1 Env glycoprotein, we identified and confirmed antibodies targeting multiple sites of vulnerability on Env, including the CD4-binding site and the V3-glycan site.	Polysaccharides	213-219	endogenous retrovirus group K member 20	Homo sapiens	166-169
35316032-5	2022	The chemoenzymatic approach was highly specific for Fc glycan remodeling when both Fc and Fab domains were glycosylated, as exemplified by the selective Fc-glycan remodeling of cetuximab.	Polysaccharides	55-61	FA complementation group B	Homo sapiens	90-93
35316032-5	2022	The chemoenzymatic approach was highly specific for Fc glycan remodeling when both Fc and Fab domains were glycosylated, as exemplified by the selective Fc-glycan remodeling of cetuximab.	Polysaccharides	156-162	FA complementation group B	Homo sapiens	90-93
35244109-5	2022	Additionally, both polysaccharides inhibited damage induced by lipopolysaccharides to the densification of the Caco-2 monolayer membrane by regulating the expressions of TLR4, ZO-1, and occludin.	Polysaccharides	19-34	toll like receptor 4	Homo sapiens	170-174
35244109-5	2022	Additionally, both polysaccharides inhibited damage induced by lipopolysaccharides to the densification of the Caco-2 monolayer membrane by regulating the expressions of TLR4, ZO-1, and occludin.	Polysaccharides	19-34	tight junction protein 1	Homo sapiens	176-180
35244109-5	2022	Additionally, both polysaccharides inhibited damage induced by lipopolysaccharides to the densification of the Caco-2 monolayer membrane by regulating the expressions of TLR4, ZO-1, and occludin.	Polysaccharides	19-34	occludin	Homo sapiens	186-194
35149460-7	2022	Glycans with the disialoside sequence alpha(2,3)alpha(2,8)/alpha(2,6)alpha(2,8) showed high specificity and affinity for Siglec-7, and sLex alpha(2,3) exhibited a strong affinity for Siglec-9.	Polysaccharides	0-7	sialic acid binding Ig like lectin 7	Homo sapiens	121-129
35027136-0	2022	The structures of two polysaccharides from Angelica sinensis and their effects on hepatic insulin resistance through blocking RAGE.	Polysaccharides	22-37	advanced glycosylation end product-specific receptor	Rattus norvegicus	126-130
35149460-7	2022	Glycans with the disialoside sequence alpha(2,3)alpha(2,8)/alpha(2,6)alpha(2,8) showed high specificity and affinity for Siglec-7, and sLex alpha(2,3) exhibited a strong affinity for Siglec-9.	Polysaccharides	0-7	sialic acid binding Ig like lectin 9	Homo sapiens	183-191
35063487-0	2022	Immunomodulation effect of polysaccharides from liquid fermentation of Monascus purpureus 40269 via membrane TLR-4 to activate the MAPK and NF-kappaB signaling pathways.	Polysaccharides	27-42	toll-like receptor 4	Mus musculus	109-114
35063487-0	2022	Immunomodulation effect of polysaccharides from liquid fermentation of Monascus purpureus 40269 via membrane TLR-4 to activate the MAPK and NF-kappaB signaling pathways.	Polysaccharides	27-42	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	140-149
34998886-1	2022	In the present study, a purified polysaccharide (named SCP-1, Mw 1.368 x 104 Da) was isolated from Sparassis crispa, and its biological activity was evaluated in an oxidative stress model caused by H2O2 in hippocampal neuronal HT22 cells.	Polysaccharides	33-47	stem cell proliferation 1	Mus musculus	55-60
35170309-4	2022	To overcome current challenges, in this study, a potential conjugate vaccine was developed by linking O-specific polysaccharide (OSP) antigen purified from V. cholerae O1 El Tor Inaba strain PIC018 with Qbeta virus-like particles efficiently via squarate chemistry.	Polysaccharides	113-127	claudin 11	Mus musculus	129-132
35372520-10	2022	The results showed that hydrogen bonds mediated the interactions between ACE2 glycans and S protein with desialylated glycans forming significantly fewer hydrogen bonds.	Polysaccharides	78-85	angiotensin converting enzyme 2	Homo sapiens	73-77
35372520-10	2022	The results showed that hydrogen bonds mediated the interactions between ACE2 glycans and S protein with desialylated glycans forming significantly fewer hydrogen bonds.	Polysaccharides	118-125	angiotensin converting enzyme 2	Homo sapiens	73-77
35372520-11	2022	These results supported a mechanism where the virus binds initially to glycans on host cells preferring alpha-(2,6)-sialic acids and finds ACE2 and with the proper orientation infects the cell.	Polysaccharides	71-78	angiotensin converting enzyme 2	Homo sapiens	139-143
35170609-3	2022	In this paper, an acidic polysaccharide (CYPB) was isolated from Chinese yam with the molecular weight of 1.55 x 102 kDa.	Polysaccharides	25-39	cytochrome P450, family 4, subfamily a, polypeptide 28, pseudogene	Mus musculus	41-45
35327223-1	2022	This study aimed to characterize the structure of Chinese yam (Dioscoreae Rhizoma) polysaccharide (CYP) and to investigate its protective effect against H2O2-induced oxidative damage in IEC-6 cells.	Polysaccharides	83-97	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	99-102
34978765-3	2022	To fine tune galectin-1 specificity, we introduced several non-canonical tryptophan analogs at this position of human galectin-1 and analyzed the resulting variants using glycan microarrays.	Polysaccharides	171-177	galectin 1	Homo sapiens	13-23
35199807-0	2022	Hypoglycemic effect of a novel polysaccharide from Lentinus edodes on STZ-induced diabetic mice via metabolomics study and Nrf2/HO-1 pathway.	Polysaccharides	31-45	nuclear factor, erythroid derived 2, like 2	Mus musculus	123-127
35199807-0	2022	Hypoglycemic effect of a novel polysaccharide from Lentinus edodes on STZ-induced diabetic mice via metabolomics study and Nrf2/HO-1 pathway.	Polysaccharides	31-45	heme oxygenase 1	Mus musculus	128-132
34981854-6	2022	Our data demonstrate that FGFR4 has multiple glycoforms, with predominant bands relating to the full-length receptor that has a high mannose- or hybrid-type form and a complex-type glycan form.	Polysaccharides	181-187	fibroblast growth factor receptor 4	Homo sapiens	26-31
35267641-0	2022	The B-Cell-Specific Ablation of B4GALT1 Reduces Cancer Formation and Reverses the Changes in Serum IgG Glycans during the Induction of Mouse Hepatocellular Carcinoma.	Polysaccharides	103-110	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	Mus musculus	32-39
35267641-4	2022	Then, the effect of the B-cell-specific ablation of beta1,4galactosyltransferase 1 (CKO B4GALT1) and B4GALT1 defects on the IgG glycans that were modified during the model induction process and HCC formation is investigated in this study.	Polysaccharides	128-135	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	Mus musculus	52-82
35267641-4	2022	Then, the effect of the B-cell-specific ablation of beta1,4galactosyltransferase 1 (CKO B4GALT1) and B4GALT1 defects on the IgG glycans that were modified during the model induction process and HCC formation is investigated in this study.	Polysaccharides	128-135	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	Mus musculus	88-95
35267641-4	2022	Then, the effect of the B-cell-specific ablation of beta1,4galactosyltransferase 1 (CKO B4GALT1) and B4GALT1 defects on the IgG glycans that were modified during the model induction process and HCC formation is investigated in this study.	Polysaccharides	128-135	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	Mus musculus	101-108
34981854-10	2022	Inhibition of glycosylation using NGI-1, an oligosaccharyltransferase inhibitor, reduced both high mannose- or hybrid- and complex-type glycan forms of FGFR4, increased processing and sensitized to apoptosis.	Polysaccharides	136-142	fibroblast growth factor receptor 4	Homo sapiens	152-157
35279348-4	2022	The HIV type-1 (HIV-1) envelope glycoprotein (Env) is heavily glycosylated, which broadly acts to shield neutralisation-relevant protein surfaces with immunorecessive self-glycans to hinder B cell recognition.	Polysaccharides	172-179	endogenous retrovirus group K member 20	Homo sapiens	23-44
35279348-4	2022	The HIV type-1 (HIV-1) envelope glycoprotein (Env) is heavily glycosylated, which broadly acts to shield neutralisation-relevant protein surfaces with immunorecessive self-glycans to hinder B cell recognition.	Polysaccharides	172-179	endogenous retrovirus group K member 20	Homo sapiens	46-49
35182405-4	2022	To address this void in knowledge, we report that ITLN2 exhibits discrete, yet notable differences from ITLN1 in primary structure, including a unique amino terminus, as well as changes in amino acid residues associated with the glycan-binding activity of ITLN1.	Polysaccharides	229-235	intelectin 2	Homo sapiens	50-55
35182405-4	2022	To address this void in knowledge, we report that ITLN2 exhibits discrete, yet notable differences from ITLN1 in primary structure, including a unique amino terminus, as well as changes in amino acid residues associated with the glycan-binding activity of ITLN1.	Polysaccharides	229-235	intelectin 1	Homo sapiens	256-261
34999393-0	2022	Polysaccharides from Platycodonis Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways.	Polysaccharides	0-15	sirtuin 1	Homo sapiens	181-186
35151686-2	2022	Although some GPI-anchored proteins (GPI-APs), including the prion protein PrPC, have a glycan side chain composed of N-acetylgalactosamine (GalNAc)-galactose-sialic acid on the core structure of GPI glycolipid, in vivo functions of this GPI-GalNAc side chain are largely unresolved.	Polysaccharides	88-94	prion protein	Mus musculus	75-79
35264966-5	2022	In this study, we investigate the properties of polysaccharides of A. bracteate, named ABP.	Polysaccharides	48-63	amine oxidase, copper-containing 1	Mus musculus	87-90
34709692-5	2022	Significantly, many glycans structures are identical on both host and pathogen (e.g. the Lewis (Le) X glycan), allowing the use of Fc CLR fusion proteins with known endogenous and/or exogenous ligands as tools to identify pathogen structures that are able to interact with the immune system.	Polysaccharides	20-27	C-type lectin domain family 4 member D	Homo sapiens	134-137
34709692-5	2022	Significantly, many glycans structures are identical on both host and pathogen (e.g. the Lewis (Le) X glycan), allowing the use of Fc CLR fusion proteins with known endogenous and/or exogenous ligands as tools to identify pathogen structures that are able to interact with the immune system.	Polysaccharides	102-108	C-type lectin domain family 4 member D	Homo sapiens	134-137
35268907-4	2022	Herein, we have classified and discussed the structure, properties and application of major polysaccharide-based electroactive hydrogels (hyaluronic acid (HA), alginate sodium (SA), chitosan (CS) and cellulose) in biomedical applications, starting with the brief historical account of MXene"s development followed by successive discussions on the synthesis methods, structures and properties of nanocomposites encompassing polysaccharides and MXenes, including their biomedical applications, cytotoxicity and biocompatibility aspects.	Polysaccharides	92-106	citrate synthase	Homo sapiens	192-194
35088782-0	2022	Polysaccharide from Ganoderma lucidum alleviates cognitive impairment in a mouse model of chronic cerebral hypoperfusion by regulating CD4+CD25+Foxp3+ regulatory T cells.	Polysaccharides	0-14	CD4 antigen	Mus musculus	135-138
35088782-0	2022	Polysaccharide from Ganoderma lucidum alleviates cognitive impairment in a mouse model of chronic cerebral hypoperfusion by regulating CD4+CD25+Foxp3+ regulatory T cells.	Polysaccharides	0-14	interleukin 2 receptor, alpha chain	Mus musculus	139-143
35088782-0	2022	Polysaccharide from Ganoderma lucidum alleviates cognitive impairment in a mouse model of chronic cerebral hypoperfusion by regulating CD4+CD25+Foxp3+ regulatory T cells.	Polysaccharides	0-14	forkhead box P3	Mus musculus	144-149
35107114-0	2022	Lyophyllum decastes fruiting body polysaccharide alleviates acute liver injury by activating the Nrf2 signaling pathway.	Polysaccharides	34-48	nuclear factor, erythroid derived 2, like 2	Mus musculus	97-101
35107114-2	2022	In this study, the ability of the Lyophyllum decastes fruiting body polysaccharide (LDFP) to protect against CCl4-induced acute liver injury in mice by activating the Nrf2 pathway was studied.	Polysaccharides	68-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	167-171
35236989-6	2022	B cells specific for a model trophoblast antigen are strongly suppressed through CD22-LYN inhibitory signalling, which in turn implicates the sialylated glycans of the antigen as key suppressive determinants.	Polysaccharides	153-160	CD22 antigen	Mus musculus	81-85
35236989-6	2022	B cells specific for a model trophoblast antigen are strongly suppressed through CD22-LYN inhibitory signalling, which in turn implicates the sialylated glycans of the antigen as key suppressive determinants.	Polysaccharides	153-160	LYN proto-oncogene, Src family tyrosine kinase	Mus musculus	86-89
35144109-3	2022	In a participant developed V3-glycan NAb response, naturally selected escape mutations at the V3 N301 and N332 glycan sites abrogated CCR8 usage while conferred APJ usage on the cognate T/F strain.	Polysaccharides	111-117	C-C motif chemokine receptor 8	Homo sapiens	134-138
35144109-4	2022	Mutations at the N301 glycan also impaired CCR3 usage and partially compromised the efficiency in using CCR5, which could be fully restored by a single escape mutation at the N332 glycan site.	Polysaccharides	22-28	C-C motif chemokine receptor 3	Homo sapiens	43-47
35144109-4	2022	Mutations at the N301 glycan also impaired CCR3 usage and partially compromised the efficiency in using CCR5, which could be fully restored by a single escape mutation at the N332 glycan site.	Polysaccharides	22-28	C-C motif chemokine receptor 5	Homo sapiens	104-108
35144109-4	2022	Mutations at the N301 glycan also impaired CCR3 usage and partially compromised the efficiency in using CCR5, which could be fully restored by a single escape mutation at the N332 glycan site.	Polysaccharides	180-186	C-C motif chemokine receptor 5	Homo sapiens	104-108
35228534-9	2022	In summary, SOSIP.v9 trimers and their glycan masked versions represent an improved platform for HIV-1 Env based vaccination strategies.	Polysaccharides	39-45	endogenous retrovirus group K member 20	Homo sapiens	103-106
35217678-4	2022	However, the presence of cytoplasmic glycoproteins, gangliosides, and lectins involved in cellular metabolism and glycan recognition has suggested the functional importance of cytosolic Neu2 sialidases.	Polysaccharides	114-120	neuraminidase 2	Homo sapiens	186-190
35112841-4	2022	Herein, we report that CUR-encapsulated polysaccharide nanoparticles (CUR-PS-NPs) potently inhibit the release of cytokines, chemokines, and growth factors associated with damage of SARS-CoV-2 spike protein (CoV2-SP)-stimulated liver Huh7.5 and lung A549 epithelial cells.	Polysaccharides	40-54	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	193-198
35215371-5	2022	In the current study, a small library of sulfated glycans and highly negatively charged compounds, including pentosan polysulfate (PPS), mucopolysaccharide polysulfate (MPS), sulfated lactobionic acid, sulodexide, and defibrotide, was assembled and evaluated for binding to the S-proteins and inhibition of viral infectivity in vitro.	Polysaccharides	50-57	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	278-279
35108536-2	2022	Biophysical analyses show that removal of either virion- or cell-associated N-glycans impairs virus-cell binding, and a similar glycan-dependent relationship is observed between purified HIV envelope (Env) and primary T cells.	Polysaccharides	128-134	endogenous retrovirus group K member 20	Homo sapiens	201-204
35020348-0	2022	Enhancement of Gene Knockdown on CD22-Expressing Cells by Chemically Modified Glycan Ligand-siRNA Conjugates.	Polysaccharides	78-84	CD22 molecule	Homo sapiens	33-37
35020348-3	2022	Here we report the uptake and enhancement of siRNA gene expression knockdown in CD22-expressing B cells using a chemically stabilized and modified CD22 glycan ligand-conjugated siRNA.	Polysaccharides	152-158	CD22 molecule	Homo sapiens	80-84
35020348-3	2022	Here we report the uptake and enhancement of siRNA gene expression knockdown in CD22-expressing B cells using a chemically stabilized and modified CD22 glycan ligand-conjugated siRNA.	Polysaccharides	152-158	CD22 molecule	Homo sapiens	147-151
35198253-8	2022	MAGT1 also acts as an accessory protein for STT3B, as catalytic subunits of the oligosaccharyltransferase protein complex, which carries out glycan chain transfer to proteins in the endoplasmic reticulum during N-glycosylation.	Polysaccharides	141-147	magnesium transporter 1	Homo sapiens	0-5
35198253-8	2022	MAGT1 also acts as an accessory protein for STT3B, as catalytic subunits of the oligosaccharyltransferase protein complex, which carries out glycan chain transfer to proteins in the endoplasmic reticulum during N-glycosylation.	Polysaccharides	141-147	STT3 oligosaccharyltransferase complex catalytic subunit B	Homo sapiens	44-49
35173433-4	2022	Methods: An iRGD tumor-penetrating peptide-modified nano-delivery system (denoted as iRGD-PSS@PBAE@JQ1/ORI nanoparticles) based on a marine sulfated polysaccharide was developed by codelivery of JQ1 (BET inhibitor) and oridonin (ORI, bioactive diterpenoid derived from traditional Chinese medicine herb).	Polysaccharides	149-163	delta/notch like EGF repeat containing	Homo sapiens	200-203
35108536-8	2022	Binding and fluorescent imaging data support glycan-glycan interactions as being responsible, at least in part, for initiating contact between HIV and the host cell, prior to viral Env-cellular CD4 engagement.	Polysaccharides	45-51	endogenous retrovirus group K member 20	Homo sapiens	181-184
35108536-8	2022	Binding and fluorescent imaging data support glycan-glycan interactions as being responsible, at least in part, for initiating contact between HIV and the host cell, prior to viral Env-cellular CD4 engagement.	Polysaccharides	45-51	CD4 molecule	Homo sapiens	194-197
35108536-8	2022	Binding and fluorescent imaging data support glycan-glycan interactions as being responsible, at least in part, for initiating contact between HIV and the host cell, prior to viral Env-cellular CD4 engagement.	Polysaccharides	52-58	endogenous retrovirus group K member 20	Homo sapiens	181-184
35108536-8	2022	Binding and fluorescent imaging data support glycan-glycan interactions as being responsible, at least in part, for initiating contact between HIV and the host cell, prior to viral Env-cellular CD4 engagement.	Polysaccharides	52-58	CD4 molecule	Homo sapiens	194-197
35178379-2	2021	The SARS-CoV-2 spike protein is heavily glycosylated and host-derived glycan modifications contribute to the formation of specific immunogenic epitopes, enhance the virus-cell interaction or affect virus transmission.	Polysaccharides	70-76	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	15-20
35102342-4	2022	MBL bound trimeric spike protein, including that of variants of concern (VoC), in a glycan-dependent manner and inhibited SARS-CoV-2 in three in vitro models.	Polysaccharides	84-90	mannose binding lectin 2	Homo sapiens	0-3
35178035-0	2021	The Trimeric Autotransporter Adhesin YadA of Yersinia enterocolitica Serotype O:9 Binds Glycan Moieties.	Polysaccharides	88-94	Adhesin	Yersinia enterocolitica	37-41
35178035-3	2021	Here, we show for the first time that YadA of Yersinia enterocolitica serotype O:9 not only interacts with proteinaceous surface molecules but can also attach directly to glycan moieties.	Polysaccharides	171-177	Adhesin	Yersinia enterocolitica	38-42
35178035-5	2021	We also show that YadA can target other glycan moieties as found in heparin, for example.	Polysaccharides	40-46	Adhesin	Yersinia enterocolitica	18-22
35102342-4	2022	MBL bound trimeric spike protein, including that of variants of concern (VoC), in a glycan-dependent manner and inhibited SARS-CoV-2 in three in vitro models.	Polysaccharides	84-90	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	19-24
35155528-9	2021	Conclusion: Polysaccharides and bibenzyls are the major active compounds in medicinal dendrobiums for diabetic management through the mechanisms of lowering glucose level and reversing chronic inflammation of T2DM by modulating pancreatic beta-cell dysfunction and insulin resistance in liver as a result from gut microbita regulation.	Polysaccharides	12-27	insulin	Homo sapiens	265-272
35238778-4	2022	The gastric gland cells which were isolated from formalin-fixed, paraffin-embedded gastric mucosal biopsy samples using laser capture microdissection were used for lectin microarray to obtain lectin-glycan interaction values.	Polysaccharides	199-205	LTL	Solanum lycopersicum	192-198
35153762-0	2021	P. granatum Peel Polysaccharides Ameliorate Imiquimod-Induced Psoriasis-Like Dermatitis in Mice via Suppression of NF-kappaB and STAT3 Pathways.	Polysaccharides	17-32	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-124
35153762-0	2021	P. granatum Peel Polysaccharides Ameliorate Imiquimod-Induced Psoriasis-Like Dermatitis in Mice via Suppression of NF-kappaB and STAT3 Pathways.	Polysaccharides	17-32	signal transducer and activator of transcription 3	Mus musculus	129-134
35106375-7	2022	Glycan array analysis of antisera indicated that the azido-GH glycoconjugate with azide at Gal-C6 of Lac (1-CRM197) elicited the highest antibody response not only to GH, SSEA3, and SSEA4, which share the common SSEA3 epitope, but also to MCF-7 cancer cells, which express these Globo-series glycans.	Polysaccharides	0-6	gamma-glutamyl hydrolase	Homo sapiens	59-61
35545360-0	2022	Astragalus polysaccharides affects multidrug resistance gene 1 and P-glycoprotein 170 in adriamycin nephropathy rats via regulating microRNA-16/NF-kappaB axis.	Polysaccharides	11-26	microRNA 16	Rattus norvegicus	132-143
35545360-2	2022	The aim of this study is to explore the effect of astragalus polysaccharides (APS) on multidrug resistance gene 1 (MDR1) and P-glycoprotein 170 (P-gp170) in adriamycin nephropathy rats and the underlying mechanisms.	Polysaccharides	61-76	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	115-119
35106375-7	2022	Glycan array analysis of antisera indicated that the azido-GH glycoconjugate with azide at Gal-C6 of Lac (1-CRM197) elicited the highest antibody response not only to GH, SSEA3, and SSEA4, which share the common SSEA3 epitope, but also to MCF-7 cancer cells, which express these Globo-series glycans.	Polysaccharides	0-6	lactase	Homo sapiens	101-104
35106375-7	2022	Glycan array analysis of antisera indicated that the azido-GH glycoconjugate with azide at Gal-C6 of Lac (1-CRM197) elicited the highest antibody response not only to GH, SSEA3, and SSEA4, which share the common SSEA3 epitope, but also to MCF-7 cancer cells, which express these Globo-series glycans.	Polysaccharides	292-299	gamma-glutamyl hydrolase	Homo sapiens	59-61
35106375-7	2022	Glycan array analysis of antisera indicated that the azido-GH glycoconjugate with azide at Gal-C6 of Lac (1-CRM197) elicited the highest antibody response not only to GH, SSEA3, and SSEA4, which share the common SSEA3 epitope, but also to MCF-7 cancer cells, which express these Globo-series glycans.	Polysaccharides	292-299	lactase	Homo sapiens	101-104
35432971-1	2022	This study aimed to evaluate the immunomodulatory effect of the polysaccharide from Sinonovacula constricta (SCP-1-1) in RAW264.7 cells.	Polysaccharides	64-78	stem cell proliferation 1	Mus musculus	109-116
35215258-8	2022	Our results showed a different tendency of the two galectins in their binding capacities towards the glycans, depending on whether they were free oligosaccharides or as part of GSL inserted into a lipid bilayer, highlighting the significance of GSL glycan presentation on membranes in lectin binding.	Polysaccharides	101-108	cathepsin A	Homo sapiens	177-180
35215258-8	2022	Our results showed a different tendency of the two galectins in their binding capacities towards the glycans, depending on whether they were free oligosaccharides or as part of GSL inserted into a lipid bilayer, highlighting the significance of GSL glycan presentation on membranes in lectin binding.	Polysaccharides	101-108	cathepsin A	Homo sapiens	245-248
34907410-4	2022	A combined approach of atomistic molecular dynamics simulation and experimental assays revealed that CP exerts a membrane directed bactericidal action through an atypical "non-pore forming" pathway which is not yet established for any known antibacterial polysaccharides.	Polysaccharides	255-270	ceruloplasmin	Homo sapiens	101-103
35200618-5	2022	In the present study, we used alginate, a natural polysaccharide extracted from a brown algae Bifurcaria bifurcata, to activate date palm defenses, which involve phenylalanine ammonia-lyase (PAL), a key enzyme of phenylpropanoid metabolism.	Polysaccharides	50-64	phenylalanine ammonia-lyase	Phoenix dactylifera	162-189
35200618-5	2022	In the present study, we used alginate, a natural polysaccharide extracted from a brown algae Bifurcaria bifurcata, to activate date palm defenses, which involve phenylalanine ammonia-lyase (PAL), a key enzyme of phenylpropanoid metabolism.	Polysaccharides	50-64	phenylalanine ammonia-lyase	Phoenix dactylifera	191-194
35127651-7	2021	The most recent researches (since 2017) have been covered and an updated overview about hybrid PCL nanofibers is presented with focus on those including nature-derived additives, e.g., polysaccharides and proteins, and synthetic additives, e.g., inorganic and carbon nanomaterials.	Polysaccharides	185-200	PHD finger protein 1	Homo sapiens	95-98
35159151-3	2022	The glycans are linked to glycoproteins that occur as metastable prefusion glycoproteins on the surface of infectious virions such as gp120 of HIV, hemagglutinin of influenza, or spike proteins of beta-coronaviruses.	Polysaccharides	4-11	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	134-139
35159151-5	2022	Other plant lectins with Neu5Ac specificity or GalNAc/T/Tn specificity can also serve as potential glycan probes for the often sialylated complex glycans and truncated O-glycans, respectively, which are abundantly distributed in the glycan shield of enveloped viruses.	Polysaccharides	99-105	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	47-55
35159151-5	2022	Other plant lectins with Neu5Ac specificity or GalNAc/T/Tn specificity can also serve as potential glycan probes for the often sialylated complex glycans and truncated O-glycans, respectively, which are abundantly distributed in the glycan shield of enveloped viruses.	Polysaccharides	146-153	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	47-55
35160376-2	2022	Chitosan (CS), as a naturally occurring biodegradable and biocompatible polysaccharide, is successfully utilized as an ideal template for the immobilization of metal oxide nanoparticles.	Polysaccharides	72-86	citrate synthase	Homo sapiens	10-12
35017217-3	2022	Although CTLA-4 and programmed death-1 (PD-1) are well-established checkpoints that inhibit T cell activity, the engagement of glycans and glycan-binding proteins are a growing area of interest due to their immunomodulatory effects.	Polysaccharides	127-134	cytotoxic T-lymphocyte protein 4	Sus scrofa	9-15
35053972-1	2022	This study was designed to explore the beneficial effect and mechanism of Ganoderma atrum (G. atrum) polysaccharide (PSG-1) on acrolein-induced IEC-6 cells.	Polysaccharides	101-115	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	117-122
35017217-3	2022	Although CTLA-4 and programmed death-1 (PD-1) are well-established checkpoints that inhibit T cell activity, the engagement of glycans and glycan-binding proteins are a growing area of interest due to their immunomodulatory effects.	Polysaccharides	139-145	cytotoxic T-lymphocyte protein 4	Sus scrofa	9-15
35059552-7	2022	A polysaccharide degradation-related gene, LOC102601831, and a sugar transport gene, LOC102587850 (SWEET6a), are dramatically up-regulated in degradating tubers according to transcriptomic analysis, as validated by qRT-PCT.	Polysaccharides	2-16	polygalacturonase-like	Solanum tuberosum	43-55
35017635-4	2022	These different glycan profiles, confirmed by glycomics, can be distinguished by the expression of O-glycan fucosylated structures, present only in epithelial cells and regulated by the expression of GALNT3.	Polysaccharides	16-22	polypeptide N-acetylgalactosaminyltransferase 3	Homo sapiens	200-206
35024716-7	2022	The ATR-FTIR data, coupled with high-resolution microscopy, reveals major physical and bio-chemical changes to the phospholipids and amide I and II proteins, as well as minor chemical changes to the structural polysaccharides and nucleic acids when compared to untreated cells.	Polysaccharides	210-225	ATR serine/threonine kinase	Homo sapiens	4-7
35017635-5	2022	Moreover, these fucosylated glycans can serve as ligands for DC-SIGN positive tumour-associated macrophages, modulating their activation and inducing the production of IL-10.	Polysaccharides	28-35	CD209 molecule	Homo sapiens	61-68
35017635-5	2022	Moreover, these fucosylated glycans can serve as ligands for DC-SIGN positive tumour-associated macrophages, modulating their activation and inducing the production of IL-10.	Polysaccharides	28-35	interleukin 10	Homo sapiens	168-173
35118215-5	2022	In addition to melanin, SP-D also interacts with galactomannan (GM) and galactosaminogalactan (GAG), the cell wall polysaccharides exposed on germinating conidial surfaces.	Polysaccharides	115-130	surfactant protein D	Homo sapiens	24-28
35118215-8	2022	Conidial germination in the presence of SP-D significantly increased the exposure of cell wall polysaccharides chitin, alpha-1,3-glucan and GAG, and decreased beta-1,3-glucan exposure on hyphae, but that of GM was unaltered.	Polysaccharides	95-110	surfactant protein D	Homo sapiens	40-44
35054804-2	2022	Submerged cultures and extracts of C. lacerata mycelia (CLM) have been reported to contain various active ingredients, including beta-glucan and extracellular polysaccharides, and to exert anti-diabetogenic properties in mice and cell lines.	Polysaccharides	159-174	CD300C molecule 2	Mus musculus	56-59
34997594-0	2022	Extraction optimization, physicochemical property, antioxidant activity and alpha-glucosidase inhibitory effect of polysaccharides from lotus seedpods.	Polysaccharides	115-130	alpha-glucosidase	Nelumbo nucifera	76-93
34997594-4	2022	For recycling lotus seedpods, the extraction optimization, physicochemical properties, antioxidant activity and alpha-glucosidase inhibitory effect of the contained polysaccharides were firstly investigated in the present study.	Polysaccharides	165-180	alpha-glucosidase	Nelumbo nucifera	112-129
34997594-9	2022	Biological evaluations showed that the polysaccharide possessed good scavenging activity on 2,2"-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt, 1,1-diphenyl-2-picryl-hydrozyl and hydroxyl radicals, and exerted obvious inhibitory effect on alpha-glucosidase activity.	Polysaccharides	39-53	alpha-glucosidase	Nelumbo nucifera	259-276
34997594-10	2022	Moreover, the polysaccharide was determined to be a mixed-type noncompetitive inhibitor of alpha-glucosidase.	Polysaccharides	14-28	alpha-glucosidase	Nelumbo nucifera	91-108
35053234-8	2022	The focus on structural glycomics defined the structure of human brain N-glycans, amongst these are HNK-1 containing glycans, a bisecting sialyl-lactose and structures with fucose and N-acetylgalactosamine on the same arm, the so-called LDNF epitope often associated with parasitic worms.	Polysaccharides	117-124	beta-1,3-glucuronyltransferase 1	Homo sapiens	100-105
35069504-2	2021	Two hypotheses have been proposed: ABO compatibility-dependence (neutralization by anti-ABO antibodies) and ABO-dependent intrinsic susceptibility (spike protein attachment to histo-blood group glycans).	Polysaccharides	194-201	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	108-111
35182063-2	2022	PCL alongside proteins and polysaccharides, like gelatin (GEL) and chondroitin sulphate (CS), can be used to fabricate composite scaffolds that provide mechanical and biological requirements for skin tissue engineering scaffolds.	Polysaccharides	27-42	citrate synthase	Homo sapiens	89-91
35095219-3	2022	To address these issues, the effect of short processing time (30-180 s) with hydrodynamic (HC) and acoustic cavitation (AC) on the dispersibility and gelling functionality of mandarin pectin-rich polysaccharide (M-PRP) was investigated.	Polysaccharides	196-210	prion protein	Homo sapiens	214-217
35426328-0	2022	Polysaccharides Produced by the Mushroom Trametes robiniophila Murr Boosts the Sensitivity of Hepatoma Cells to Oxaliplatin via the miR-224-5p/ABCB1/P-gp Axis.	Polysaccharides	0-15	microRNA 224	Homo sapiens	132-139
35426328-0	2022	Polysaccharides Produced by the Mushroom Trametes robiniophila Murr Boosts the Sensitivity of Hepatoma Cells to Oxaliplatin via the miR-224-5p/ABCB1/P-gp Axis.	Polysaccharides	0-15	ATP binding cassette subfamily B member 1	Homo sapiens	143-148
35426328-0	2022	Polysaccharides Produced by the Mushroom Trametes robiniophila Murr Boosts the Sensitivity of Hepatoma Cells to Oxaliplatin via the miR-224-5p/ABCB1/P-gp Axis.	Polysaccharides	0-15	phosphoglycolate phosphatase	Homo sapiens	149-153
34511508-2	2022	GNE encodes UDP-GlcNAc epimerase/Mannose-6 kinase, a protein with two enzymatic activities that comprise the committed step in biosynthesis of sialic acid (SA), an essential glycan that appears on the terminal positions of many extracellular oligosaccharide chains.	Polysaccharides	174-180	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Mus musculus	0-3