PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17662150-0	2007	Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children.	Propylthiouracil	57-77	taste 2 receptor member 38	Homo sapiens	30-37
17662150-0	2007	Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children.	Propylthiouracil	79-83	taste 2 receptor member 38	Homo sapiens	30-37
17070108-0	2007	Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis.	Propylthiouracil	61-77	myeloperoxidase	Homo sapiens	36-51
17307996-7	2007	This promoter was activated in control heart and decreased greatly in response to propylthiouracil and streptozotocin and increased in hyperthyroid rats, similar in pattern to the endogenous AS beta RNA.	Propylthiouracil	82-98	arylsulfatase B	Rattus norvegicus	191-198
17371473-1	2007	OBJECTIVE: Propylthiouracil (PTU) has been known to induce myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) positive vasculitis.	Propylthiouracil	11-27	myeloperoxidase	Homo sapiens	112-115
17371473-1	2007	OBJECTIVE: Propylthiouracil (PTU) has been known to induce myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) positive vasculitis.	Propylthiouracil	29-32	myeloperoxidase	Homo sapiens	112-115
17371473-2	2007	Our previous study indicated that the increase of avidity of MPO-ANCA might be associated with the occurrence of clinical vasculitis in patients with PTU-induced ANCA.	Propylthiouracil	150-153	myeloperoxidase	Homo sapiens	61-64
17371473-3	2007	The current study aimed to follow-up the avidity and titre of anti-MPO antibodies in sequential sera from patients with PTU-induced ANCA-associated systemic vasculitis (AASV).	Propylthiouracil	120-123	myeloperoxidase	Homo sapiens	67-70
17371473-8	2007	RESULTS: After cessation of PTU and initiation of immunosuppressive therapy, the avidity and titre of MPO-ANCA decreased significantly during follow-up in sera from all the patients, and the avidity decreased much more quickly than the titres.	Propylthiouracil	28-31	myeloperoxidase	Homo sapiens	102-105
17192293-11	2007	In addition, PTU dissociated nuclear coactivators, such as steroid receptor coactivator-1 and glucocorticoid receptor interacting protein-1, from the TR in the presence of T(3).	Propylthiouracil	13-16	nuclear receptor coactivator 2	Homo sapiens	76-139
17250611-3	2007	Other family-based studies on the genetic transmittance of taste perception have previously demonstrated a correlation between genetic variation in TAS2R38 and sensitivity to bitter-taste compounds such as phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).	Propylthiouracil	236-256	taste 2 receptor member 38	Homo sapiens	148-155
17250611-3	2007	Other family-based studies on the genetic transmittance of taste perception have previously demonstrated a correlation between genetic variation in TAS2R38 and sensitivity to bitter-taste compounds such as phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).	Propylthiouracil	258-262	taste 2 receptor member 38	Homo sapiens	148-155
17435868-2	2007	Propylthiouracil (PTU) can be associated to ANCA positive vasculitis, most often related to myeloperoxidase subtype (ANCA-MPO).	Propylthiouracil	0-16	myeloperoxidase	Homo sapiens	92-107
17435868-2	2007	Propylthiouracil (PTU) can be associated to ANCA positive vasculitis, most often related to myeloperoxidase subtype (ANCA-MPO).	Propylthiouracil	0-16	myeloperoxidase	Homo sapiens	122-125
17435868-2	2007	Propylthiouracil (PTU) can be associated to ANCA positive vasculitis, most often related to myeloperoxidase subtype (ANCA-MPO).	Propylthiouracil	18-21	myeloperoxidase	Homo sapiens	92-107
17435868-2	2007	Propylthiouracil (PTU) can be associated to ANCA positive vasculitis, most often related to myeloperoxidase subtype (ANCA-MPO).	Propylthiouracil	18-21	myeloperoxidase	Homo sapiens	122-125
17070108-0	2007	Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis.	Propylthiouracil	61-77	myeloperoxidase	Homo sapiens	53-56
17070108-0	2007	Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis.	Propylthiouracil	79-82	myeloperoxidase	Homo sapiens	36-51
17070108-0	2007	Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis.	Propylthiouracil	79-82	myeloperoxidase	Homo sapiens	53-56
17070108-0	2007	Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis.	Propylthiouracil	127-130	myeloperoxidase	Homo sapiens	36-51
17070108-0	2007	Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis.	Propylthiouracil	127-130	myeloperoxidase	Homo sapiens	53-56
17070108-0	2007	Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis.	Propylthiouracil	127-130	myeloperoxidase	Homo sapiens	93-96
17070108-4	2007	The oxidation activity of MPO was measured in the presence of PTU and MPO-ANCA-positive IgG preparations from patients with PTU-induced vasculitis and primary MPA respectively.	Propylthiouracil	62-65	myeloperoxidase	Homo sapiens	26-29
17070108-5	2007	PTU could competitively inhibit the oxidation activity of MPO dose dependently.	Propylthiouracil	0-3	myeloperoxidase	Homo sapiens	58-61
17070108-6	2007	MPO-ANCA-positive IgG preparations from 6/7 patients with PTU-induced vasculitis and only 3/10 from patients with primary MPA could inhibit the MPO activity in a dose-dependent manner.	Propylthiouracil	58-61	myeloperoxidase	Homo sapiens	0-3
17070108-6	2007	MPO-ANCA-positive IgG preparations from 6/7 patients with PTU-induced vasculitis and only 3/10 from patients with primary MPA could inhibit the MPO activity in a dose-dependent manner.	Propylthiouracil	58-61	myeloperoxidase	Homo sapiens	144-147
17070108-7	2007	In conclusions, the oxidation activity of MPO could be inhibited by PTU and PTU-induced MPO-ANCA in a dose-dependent manner, which might be involved in the pathogenesis PTU-induced vasculitis.	Propylthiouracil	68-71	myeloperoxidase	Homo sapiens	42-45
17070108-7	2007	In conclusions, the oxidation activity of MPO could be inhibited by PTU and PTU-induced MPO-ANCA in a dose-dependent manner, which might be involved in the pathogenesis PTU-induced vasculitis.	Propylthiouracil	76-79	myeloperoxidase	Homo sapiens	42-45
17070108-7	2007	In conclusions, the oxidation activity of MPO could be inhibited by PTU and PTU-induced MPO-ANCA in a dose-dependent manner, which might be involved in the pathogenesis PTU-induced vasculitis.	Propylthiouracil	76-79	myeloperoxidase	Homo sapiens	88-91
17070108-7	2007	In conclusions, the oxidation activity of MPO could be inhibited by PTU and PTU-induced MPO-ANCA in a dose-dependent manner, which might be involved in the pathogenesis PTU-induced vasculitis.	Propylthiouracil	76-79	myeloperoxidase	Homo sapiens	42-45
17070108-7	2007	In conclusions, the oxidation activity of MPO could be inhibited by PTU and PTU-induced MPO-ANCA in a dose-dependent manner, which might be involved in the pathogenesis PTU-induced vasculitis.	Propylthiouracil	76-79	myeloperoxidase	Homo sapiens	88-91
16926379-6	2007	Our results show that 6-n-propyl-2-thiouracil (PTU) treatment producing hypothyroidism induced a significant increase in the expression of PC1/3, PC2, and pro-TRH in the PVN and LH, but not VMN.	Propylthiouracil	22-45	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	139-144
16926379-6	2007	Our results show that 6-n-propyl-2-thiouracil (PTU) treatment producing hypothyroidism induced a significant increase in the expression of PC1/3, PC2, and pro-TRH in the PVN and LH, but not VMN.	Propylthiouracil	22-45	proprotein convertase subtilisin/kexin type 2	Rattus norvegicus	146-149
16926379-6	2007	Our results show that 6-n-propyl-2-thiouracil (PTU) treatment producing hypothyroidism induced a significant increase in the expression of PC1/3, PC2, and pro-TRH in the PVN and LH, but not VMN.	Propylthiouracil	22-45	thyrotropin releasing hormone	Rattus norvegicus	155-162
16926379-6	2007	Our results show that 6-n-propyl-2-thiouracil (PTU) treatment producing hypothyroidism induced a significant increase in the expression of PC1/3, PC2, and pro-TRH in the PVN and LH, but not VMN.	Propylthiouracil	47-50	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	139-144
16926379-6	2007	Our results show that 6-n-propyl-2-thiouracil (PTU) treatment producing hypothyroidism induced a significant increase in the expression of PC1/3, PC2, and pro-TRH in the PVN and LH, but not VMN.	Propylthiouracil	47-50	proprotein convertase subtilisin/kexin type 2	Rattus norvegicus	146-149
16926379-6	2007	Our results show that 6-n-propyl-2-thiouracil (PTU) treatment producing hypothyroidism induced a significant increase in the expression of PC1/3, PC2, and pro-TRH in the PVN and LH, but not VMN.	Propylthiouracil	47-50	thyrotropin releasing hormone	Rattus norvegicus	155-162
16880639-7	2006	Furthermore, the effects of TSS on levels of serum thyroid hormones and LPO were markedly decreased by propylthiouracil, an antithyroid drug.	Propylthiouracil	103-119	lactoperoxidase	Mus musculus	72-75
17329921-0	2007	Cerebral pachyleptomeningitis associated with MPO-ANCA induced by PTU therapy.	Propylthiouracil	66-69	myeloperoxidase	Homo sapiens	46-49
17329921-7	2007	This is the first report of PTU-induced cerebral pachyleptomeningitis associated with a high serum MPO-ANCA titer.	Propylthiouracil	28-31	myeloperoxidase	Homo sapiens	99-102
16601143-0	2006	Characterization of recombinant Xenopus laevis type I iodothyronine deiodinase: substitution of a proline residue in the catalytic center by serine (Pro132Ser) restores sensitivity to 6-propyl-2-thiouracil.	Propylthiouracil	184-205	deiodinase, iodothyronine type 1 L homeolog	Xenopus laevis	47-78
16494987-6	2006	As a proof of the concept, we generated transgenic worms expressing human T2R4 or its mouse ortholog T2R8 receptors, which respond to two bitter tastants previously characterised as their functional ligands, 6-n-propyl-2-thiouracil and denatoniun.	Propylthiouracil	208-231	taste 2 receptor member 4	Homo sapiens	74-78
16494987-6	2006	As a proof of the concept, we generated transgenic worms expressing human T2R4 or its mouse ortholog T2R8 receptors, which respond to two bitter tastants previously characterised as their functional ligands, 6-n-propyl-2-thiouracil and denatoniun.	Propylthiouracil	208-231	taste receptor, type 2, member 108	Mus musculus	101-105
16494987-7	2006	As expected, expression of human T2R4 or its mouse ortholog T2R8 in ASI neurons counteracted the water-soluble avoidance to 6-n-propyl-2-thiouracil and denatoniun observed in control wild-type worms.	Propylthiouracil	124-147	taste 2 receptor member 4	Homo sapiens	33-37
16494987-7	2006	As expected, expression of human T2R4 or its mouse ortholog T2R8 in ASI neurons counteracted the water-soluble avoidance to 6-n-propyl-2-thiouracil and denatoniun observed in control wild-type worms.	Propylthiouracil	124-147	taste receptor, type 2, member 108	Mus musculus	60-64
16139362-3	2006	We demonstrated a S. tropicalis metamorphosis assay based on Xenopus Metamorphosis Assay (XEMA) using 1 microg/L thyroxine (T4) and 75 mg/L propylthiouracil (PTU).	Propylthiouracil	140-156	forkhead box I1	Xenopus tropicalis	90-94
16139362-3	2006	We demonstrated a S. tropicalis metamorphosis assay based on Xenopus Metamorphosis Assay (XEMA) using 1 microg/L thyroxine (T4) and 75 mg/L propylthiouracil (PTU).	Propylthiouracil	158-161	forkhead box I1	Xenopus tropicalis	90-94
16386794-0	2006	Perinatal exposure to PTU delays switching from NR2B to NR2A subunits of the NMDA receptor in the rat cerebellum.	Propylthiouracil	22-25	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	48-52
16386794-0	2006	Perinatal exposure to PTU delays switching from NR2B to NR2A subunits of the NMDA receptor in the rat cerebellum.	Propylthiouracil	22-25	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	56-60
16386794-5	2006	PTU induced up-regulation of NR2B mRNA and down-regulation of NR2A and BDNF mRNAs in the cerebellum on PND 22, but there were no changes in the other genes (growth associated protein-43, L1, neuronal cell adhesion molecule, synaptophysin, post synaptic density-95).	Propylthiouracil	0-3	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	29-33
16386794-5	2006	PTU induced up-regulation of NR2B mRNA and down-regulation of NR2A and BDNF mRNAs in the cerebellum on PND 22, but there were no changes in the other genes (growth associated protein-43, L1, neuronal cell adhesion molecule, synaptophysin, post synaptic density-95).	Propylthiouracil	0-3	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	62-66
16386794-5	2006	PTU induced up-regulation of NR2B mRNA and down-regulation of NR2A and BDNF mRNAs in the cerebellum on PND 22, but there were no changes in the other genes (growth associated protein-43, L1, neuronal cell adhesion molecule, synaptophysin, post synaptic density-95).	Propylthiouracil	0-3	brain-derived neurotrophic factor	Rattus norvegicus	71-75
16386794-5	2006	PTU induced up-regulation of NR2B mRNA and down-regulation of NR2A and BDNF mRNAs in the cerebellum on PND 22, but there were no changes in the other genes (growth associated protein-43, L1, neuronal cell adhesion molecule, synaptophysin, post synaptic density-95).	Propylthiouracil	0-3	growth associated protein 43	Rattus norvegicus	157-185
16386794-5	2006	PTU induced up-regulation of NR2B mRNA and down-regulation of NR2A and BDNF mRNAs in the cerebellum on PND 22, but there were no changes in the other genes (growth associated protein-43, L1, neuronal cell adhesion molecule, synaptophysin, post synaptic density-95).	Propylthiouracil	0-3	neuronal cell adhesion molecule	Rattus norvegicus	191-222
16386794-5	2006	PTU induced up-regulation of NR2B mRNA and down-regulation of NR2A and BDNF mRNAs in the cerebellum on PND 22, but there were no changes in the other genes (growth associated protein-43, L1, neuronal cell adhesion molecule, synaptophysin, post synaptic density-95).	Propylthiouracil	0-3	synaptophysin	Rattus norvegicus	224-237
16386794-6	2006	Examination of the effects of PTU on maturation of NMDAR subunits (NR2A/NR2B) demonstrated changes in relative expression on PND 14, but not on PND 4, with recovery after maturation.	Propylthiouracil	30-33	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	67-71
16386794-6	2006	Examination of the effects of PTU on maturation of NMDAR subunits (NR2A/NR2B) demonstrated changes in relative expression on PND 14, but not on PND 4, with recovery after maturation.	Propylthiouracil	30-33	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	72-76
16386794-8	2006	These results suggest PTU can delay this switching from NR2B to NR2A subunits in the maturation of NMDA receptors.	Propylthiouracil	22-25	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	56-60
16386794-8	2006	These results suggest PTU can delay this switching from NR2B to NR2A subunits in the maturation of NMDA receptors.	Propylthiouracil	22-25	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	64-68
16265595-0	2005	Osteopontin gene expression in the aorta and the heart of propylthiouracil-induced hypothyroid mice.	Propylthiouracil	58-74	secreted phosphoprotein 1	Mus musculus	0-11
15823568-9	2005	Significantly altered expression of Bag3 in cerebella from PND 15 and PND 60 pups exposed to PTU suggests permanent functional alterations in the hypothyroid brain.	Propylthiouracil	93-96	BAG cochaperone 3	Homo sapiens	36-40
16019262-1	2005	OBJECTIVE: Propylthiouracil (PTU) could induce MPO-ANCA-positive vasculitis.	Propylthiouracil	11-27	myeloperoxidase	Homo sapiens	47-50
16019262-1	2005	OBJECTIVE: Propylthiouracil (PTU) could induce MPO-ANCA-positive vasculitis.	Propylthiouracil	29-32	myeloperoxidase	Homo sapiens	47-50
16019262-9	2005	The median avidity constant of MPO-ANCA was 56 (8.96 to >140) x 10(7) mol/l for patients with primary AASV and 0.7 (<0.28 to >140) x 10(7) mol/l for patients with PTU-induced vasculitis respectively.	Propylthiouracil	172-175	myeloperoxidase	Homo sapiens	31-34
16019262-10	2005	Furthermore, the relative levels of MPO-ANCA avidity were associated with elevation of ESR in primary AASV and were associated with BVAS scores in patients with PTU-induced vasculitis, respectively.	Propylthiouracil	161-164	myeloperoxidase	Homo sapiens	36-39
16019262-11	2005	CONCLUSION: MPO-ANCA IgG subclass distribution and avidity were different between patients with primary AASV and PTU-induced vasculitis.	Propylthiouracil	113-116	myeloperoxidase	Homo sapiens	12-15
15889422-1	2005	The effect of triiodo-L-thyronine (T3) and propylthiouracil (PTU) on the initiation of epidermal growth factor (EGF) expression in the sublingual glands (SLGs) of postnatal mice was investigated by indirect enzyme-labeled and immunogold antibody methods for light and electron microscopy, respectively.	Propylthiouracil	43-59	epidermal growth factor	Mus musculus	87-110
15889422-1	2005	The effect of triiodo-L-thyronine (T3) and propylthiouracil (PTU) on the initiation of epidermal growth factor (EGF) expression in the sublingual glands (SLGs) of postnatal mice was investigated by indirect enzyme-labeled and immunogold antibody methods for light and electron microscopy, respectively.	Propylthiouracil	43-59	epidermal growth factor	Mus musculus	112-115
15889422-1	2005	The effect of triiodo-L-thyronine (T3) and propylthiouracil (PTU) on the initiation of epidermal growth factor (EGF) expression in the sublingual glands (SLGs) of postnatal mice was investigated by indirect enzyme-labeled and immunogold antibody methods for light and electron microscopy, respectively.	Propylthiouracil	61-64	epidermal growth factor	Mus musculus	87-110
15889422-1	2005	The effect of triiodo-L-thyronine (T3) and propylthiouracil (PTU) on the initiation of epidermal growth factor (EGF) expression in the sublingual glands (SLGs) of postnatal mice was investigated by indirect enzyme-labeled and immunogold antibody methods for light and electron microscopy, respectively.	Propylthiouracil	61-64	epidermal growth factor	Mus musculus	112-115
15889422-7	2005	By contrast, when PTU (1 mg/kg body weight) was given to male mice every other day for 2 weeks before examination, the EGF-immunoreactive cells were markedly decreased in number compared to those of normal males of the same age.	Propylthiouracil	18-21	epidermal growth factor	Mus musculus	119-122
16178864-0	2005	Titre and affinity of propylthiouracil-induced anti-myeloperoxidase antibodies are closely associated with the development of clinical vasculitis.	Propylthiouracil	22-38	myeloperoxidase	Homo sapiens	47-67
16178864-1	2005	Substantial evidences suggested that propylthiouracil (PTU) could induced anti-myeloperoxidase (MPO) antibodies in sera from patients with hyperthyroidism, however, only a subgroup of the PTU-induced anti-MPO antibody positive patients developed clinical evident vasculitis.	Propylthiouracil	37-53	myeloperoxidase	Homo sapiens	74-94
16178864-1	2005	Substantial evidences suggested that propylthiouracil (PTU) could induced anti-myeloperoxidase (MPO) antibodies in sera from patients with hyperthyroidism, however, only a subgroup of the PTU-induced anti-MPO antibody positive patients developed clinical evident vasculitis.	Propylthiouracil	37-53	myeloperoxidase	Homo sapiens	96-99
16178864-1	2005	Substantial evidences suggested that propylthiouracil (PTU) could induced anti-myeloperoxidase (MPO) antibodies in sera from patients with hyperthyroidism, however, only a subgroup of the PTU-induced anti-MPO antibody positive patients developed clinical evident vasculitis.	Propylthiouracil	37-53	myeloperoxidase	Homo sapiens	205-208
16178864-1	2005	Substantial evidences suggested that propylthiouracil (PTU) could induced anti-myeloperoxidase (MPO) antibodies in sera from patients with hyperthyroidism, however, only a subgroup of the PTU-induced anti-MPO antibody positive patients developed clinical evident vasculitis.	Propylthiouracil	55-58	myeloperoxidase	Homo sapiens	74-94
16178864-1	2005	Substantial evidences suggested that propylthiouracil (PTU) could induced anti-myeloperoxidase (MPO) antibodies in sera from patients with hyperthyroidism, however, only a subgroup of the PTU-induced anti-MPO antibody positive patients developed clinical evident vasculitis.	Propylthiouracil	55-58	myeloperoxidase	Homo sapiens	96-99
16178864-1	2005	Substantial evidences suggested that propylthiouracil (PTU) could induced anti-myeloperoxidase (MPO) antibodies in sera from patients with hyperthyroidism, however, only a subgroup of the PTU-induced anti-MPO antibody positive patients developed clinical evident vasculitis.	Propylthiouracil	55-58	myeloperoxidase	Homo sapiens	205-208
16178864-1	2005	Substantial evidences suggested that propylthiouracil (PTU) could induced anti-myeloperoxidase (MPO) antibodies in sera from patients with hyperthyroidism, however, only a subgroup of the PTU-induced anti-MPO antibody positive patients developed clinical evident vasculitis.	Propylthiouracil	188-191	myeloperoxidase	Homo sapiens	205-208
16178864-2	2005	The aim of this study is to compare the titres and affinities of PTU induced anti-MPO antibodies in sera from patients with hyperthyroidism with and without clinical vasculitis.	Propylthiouracil	65-68	myeloperoxidase	Homo sapiens	82-85
16178864-9	2005	We concluded that the titre and affinity of anti-MPO antibodies might be associated with the development of clinical vasculitis in patients with PTU-induced ANCA.	Propylthiouracil	145-148	myeloperoxidase	Homo sapiens	49-52
15960145-0	2005	Epitope analysis of myeloperoxidase-specific antineutrophil cytoplasmic autoantibodies (MPO-ANCA) in childhood onset Graves" disease treated with propylthiouracil.	Propylthiouracil	146-162	myeloperoxidase	Homo sapiens	88-91
15960145-1	2005	AIM: This study aimed to elucidate the relationship between epitope profiles and clinical manifestations of patients with myeloperoxidase antineutrophil cytoplasmic autoantibodies-(MPO-ANCA) positive childhood onset Graves" disease treated with propylthiouracil (PTU).	Propylthiouracil	245-261	myeloperoxidase	Homo sapiens	181-184
15960145-1	2005	AIM: This study aimed to elucidate the relationship between epitope profiles and clinical manifestations of patients with myeloperoxidase antineutrophil cytoplasmic autoantibodies-(MPO-ANCA) positive childhood onset Graves" disease treated with propylthiouracil (PTU).	Propylthiouracil	263-266	myeloperoxidase	Homo sapiens	181-184
15960145-11	2005	This clonality of MPO-ANCA may be a risk factor that induces clinical vasculitis and nephritis in patients treated with PTU.	Propylthiouracil	120-123	myeloperoxidase	Homo sapiens	18-21
15960145-12	2005	Therefore, patients exposed to PTU should be monitored for MPO-ANCA level and epitopes.	Propylthiouracil	31-34	myeloperoxidase	Homo sapiens	59-62
15673845-8	2005	Phosphorylation of the extracellular signal-regulated kinases (ERK1 and ERK2) was increased as a function of LTP stimulation in slices from PTU-exposed adult animals.	Propylthiouracil	140-143	mitogen-activated protein kinase 3	Homo sapiens	63-67
15615843-10	2005	Compared with control, EAAT1 mRNA levels (arbitrary units) were increased nearly threefold in T3-treated (3.1 +/- 0.5 vs. 1.1 +/- 0.2; P < 0.05) and decreased in PTU-treated (2.0 +/- 0.	Propylthiouracil	165-168	solute carrier family 1 member 3	Rattus norvegicus	23-28
15615843-12	2005	Aralar1 mRNA levels were unchanged in T3-treated and somewhat decreased in PTU-treated (7.1 +/- 1.0 vs. 9.3 +/- 0.1, P < 0.05) rats.	Propylthiouracil	75-78	solute carrier family 25 member 12	Rattus norvegicus	0-7
15615843-14	2005	EAAT1 protein levels (arbitrary units) in T3-treated cardiac mitochondria were increased compared with controls (8.9 +/- 0.4 vs. 5.9 +/- 0.6; P < 0.005) and unchanged in PTU-treated mitochondria.	Propylthiouracil	173-176	solute carrier family 1 member 3	Rattus norvegicus	0-5
15673845-8	2005	Phosphorylation of the extracellular signal-regulated kinases (ERK1 and ERK2) was increased as a function of LTP stimulation in slices from PTU-exposed adult animals.	Propylthiouracil	140-143	mitogen-activated protein kinase 1	Homo sapiens	72-76
15723792-7	2005	These data provide a direct molecular link between heritable variability in bitter taste perception to functional variations of a single G protein coupled receptor that responds to compounds such as PTC and PROP that contain the N-C=S moiety.	Propylthiouracil	207-211	C-X-C motif chemokine receptor 6	Homo sapiens	137-163
15498825-3	2005	Rats were given propylthiouracil (PTU) for 8 days to induce a 25% increase in beta-myosin heavy chain with a 28% reduction in actomyosin ATPase activity.	Propylthiouracil	16-32	myosin heavy chain 7	Rattus norvegicus	78-101
15498825-3	2005	Rats were given propylthiouracil (PTU) for 8 days to induce a 25% increase in beta-myosin heavy chain with a 28% reduction in actomyosin ATPase activity.	Propylthiouracil	34-37	myosin heavy chain 7	Rattus norvegicus	78-101
15687429-4	2005	The present study tests the hypothesis that genetic variations in the newly discovered TAS2R38 taste gene as well as cultural differences are associated with differences in sensitivity to the bitter taste of propylthiouracil (PROP) and preferences for sucrose and sweet-tasting foods and beverages in children and adults.	Propylthiouracil	208-224	taste 2 receptor member 38	Homo sapiens	87-94
15687429-4	2005	The present study tests the hypothesis that genetic variations in the newly discovered TAS2R38 taste gene as well as cultural differences are associated with differences in sensitivity to the bitter taste of propylthiouracil (PROP) and preferences for sucrose and sweet-tasting foods and beverages in children and adults.	Propylthiouracil	226-230	taste 2 receptor member 38	Homo sapiens	87-94
15585599-3	2005	In the current study, we examined the in vivo regulation of brain PC2 mRNA by thyroid status and found that 6-n-propyl-2-thiouracil-induced hypothyroidism stimulated, whereas thyroxine-induced hyperthyroidism suppressed, PC2 mRNA levels in the rat hypothalamus and cerebral cortex.	Propylthiouracil	108-131	proprotein convertase subtilisin/kexin type 2	Rattus norvegicus	66-69
16207347-3	2005	The presence of myeloperoxidase-antineutrophil cytoplasmic antibodies, IgM anticardiolipin antibody, and antihistone antibodies in combination was found to be characteristic of drug-induced vasculitic syndromes caused by the antithyroid drugs propylthiouracil and methimazol.	Propylthiouracil	243-259	myeloperoxidase	Homo sapiens	16-31
15585599-3	2005	In the current study, we examined the in vivo regulation of brain PC2 mRNA by thyroid status and found that 6-n-propyl-2-thiouracil-induced hypothyroidism stimulated, whereas thyroxine-induced hyperthyroidism suppressed, PC2 mRNA levels in the rat hypothalamus and cerebral cortex.	Propylthiouracil	108-131	proprotein convertase subtilisin/kexin type 2	Rattus norvegicus	221-224
15473886-2	2004	The present study was designed to evaluate PON1 activity and its relationship with preatherosclerotic markers such as lipid peroxidation and insulin resistance in hyperthyroid patients before and after propylthiouracil (PTU) treatment and in subjects with iatrogenic subclinical hyperthyroidism.	Propylthiouracil	202-218	paraoxonase 1	Homo sapiens	43-47
15569009-0	2004	p16 expression in psoriatic lesions following therapy with propylthiouracil, an antithyroid thioureylene.	Propylthiouracil	59-75	cyclin dependent kinase inhibitor 2A	Homo sapiens	0-3
15569009-5	2004	This study examined p16 expression in biopsy samples of eight patients with plaque psoriasis given 300 mg of propylthiouracil in divided doses for 3 months.	Propylthiouracil	109-125	cyclin dependent kinase inhibitor 2A	Homo sapiens	20-23
15730737-0	2004	[Epitope mapping of myeloperoxidase antibodies in propylthiouracil-induced vasculitis and microscopic polyangiitis].	Propylthiouracil	50-66	myeloperoxidase	Homo sapiens	20-35
15730737-1	2004	OBJECTIVE: To compare the epitopes of antibodies for myeloperoxidase (MPO) in the serum from patients with propylthiouracil (PTU) induced vasculitis and microscopic polyangiitis (MPA).	Propylthiouracil	107-123	myeloperoxidase	Homo sapiens	53-68
15569458-1	2004	OBJECTIVE: To investigate the distribution of IgG subclass of anti-myeloperoxidase (MPO) antibodies, a kind of antineutrophil cytoplasmic autoantibody (ANCA), in sera from patients with propylthiouracil (PIU)-induced vasculitis.	Propylthiouracil	186-202	myeloperoxidase	Homo sapiens	84-87
15569458-1	2004	OBJECTIVE: To investigate the distribution of IgG subclass of anti-myeloperoxidase (MPO) antibodies, a kind of antineutrophil cytoplasmic autoantibody (ANCA), in sera from patients with propylthiouracil (PIU)-induced vasculitis.	Propylthiouracil	204-207	myeloperoxidase	Homo sapiens	84-87
15373922-0	2004	Anti-myeloperoxidase antibodies in sera from patients with propylthiouracil-induced vasculitis might recognize restricted epitopes on myeloperoxidase molecule.	Propylthiouracil	59-75	myeloperoxidase	Homo sapiens	5-20
15373922-0	2004	Anti-myeloperoxidase antibodies in sera from patients with propylthiouracil-induced vasculitis might recognize restricted epitopes on myeloperoxidase molecule.	Propylthiouracil	59-75	myeloperoxidase	Homo sapiens	134-149
15373922-2	2004	It is known that propylthiouracil (PTU) could induce MPO-ANCA-positive vasculitis.	Propylthiouracil	17-33	myeloperoxidase	Homo sapiens	53-56
15373922-2	2004	It is known that propylthiouracil (PTU) could induce MPO-ANCA-positive vasculitis.	Propylthiouracil	35-38	myeloperoxidase	Homo sapiens	53-56
15373922-3	2004	The production of anti-MPO antibodies in patients with PTU-induced vasculitis may be different from that in patients with primary microscopic polyangiitis (MPA).	Propylthiouracil	55-58	myeloperoxidase	Homo sapiens	23-26
15373922-5	2004	The aim of this study is to compare the epitopes of antibodies to MPO in sera from patients with PTU-induced vasculitis (n = 10) and MPA (n = 10).	Propylthiouracil	97-100	myeloperoxidase	Homo sapiens	66-69
15373922-13	2004	We conclude that anti-MPO antibodies from patients with PTU-induced vasculitis and from patients with primary MPA could recognize more than one epitope on the native MPO molecule.	Propylthiouracil	56-59	myeloperoxidase	Homo sapiens	22-25
15373922-13	2004	We conclude that anti-MPO antibodies from patients with PTU-induced vasculitis and from patients with primary MPA could recognize more than one epitope on the native MPO molecule.	Propylthiouracil	56-59	myeloperoxidase	Homo sapiens	166-169
15373922-14	2004	Although the epitopes overlapped between the two groups, the epitopes of anti-MPO antibodies from patients with PTU-induced vasculitis might be more restricted.	Propylthiouracil	112-115	myeloperoxidase	Homo sapiens	78-81
15649252-8	2005	Western blots and immunohistochemistry revealed constitutive COX-2 expression in non-neoplastic follicular cells of the control and all of the PTU- and SDM-treated rats.	Propylthiouracil	143-146	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	61-66
15730737-1	2004	OBJECTIVE: To compare the epitopes of antibodies for myeloperoxidase (MPO) in the serum from patients with propylthiouracil (PTU) induced vasculitis and microscopic polyangiitis (MPA).	Propylthiouracil	107-123	myeloperoxidase	Homo sapiens	70-73
15730737-1	2004	OBJECTIVE: To compare the epitopes of antibodies for myeloperoxidase (MPO) in the serum from patients with propylthiouracil (PTU) induced vasculitis and microscopic polyangiitis (MPA).	Propylthiouracil	125-128	myeloperoxidase	Homo sapiens	53-68
15730737-1	2004	OBJECTIVE: To compare the epitopes of antibodies for myeloperoxidase (MPO) in the serum from patients with propylthiouracil (PTU) induced vasculitis and microscopic polyangiitis (MPA).	Propylthiouracil	125-128	myeloperoxidase	Homo sapiens	70-73
15730737-7	2004	CONCLUSIONS: MPO antibodies from patients with PTU-induced vasculitis and patients with primary MPA could recognize more than one epitopes on native MPO molecule.	Propylthiouracil	47-50	myeloperoxidase	Homo sapiens	13-16
15730737-7	2004	CONCLUSIONS: MPO antibodies from patients with PTU-induced vasculitis and patients with primary MPA could recognize more than one epitopes on native MPO molecule.	Propylthiouracil	47-50	myeloperoxidase	Homo sapiens	149-152
15730737-8	2004	Although the epitopes were overlapping between the two groups, the epitopes of MPO antibodies from patients with PTU-induced vasculitis might be more restricted.	Propylthiouracil	113-116	myeloperoxidase	Homo sapiens	79-82
15119959-0	2004	Serum TNF-alpha in psoriasis after treatment with propylthiouracil, an antithyroid thioureylene.	Propylthiouracil	50-66	tumor necrosis factor	Homo sapiens	6-15
15326060-9	2004	Furthermore, this study confirmed that PTU dose-dependently increased expression of PTEN, a tumor suppressor gene known to be involved in the coordinate inhibition of VSMC proliferation and migration.	Propylthiouracil	39-42	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	Oryctolagus cuniculus	84-88
24387655-4	2004	After the cessation of propylthiouracil therapy and the administration of steroids, all her symptoms disappeared and the titer of antineutrophil cytoplasmic antibody against myeloperoxidase decreased.	Propylthiouracil	23-39	myeloperoxidase	Homo sapiens	174-189
15119959-3	2004	METHODS: The present study examined the effect of treatment with propylthiouracil, given in a dose of 100 mg every 8 hours for 3 months, on the serum levels of TNF-alpha in 9 patients with plaque psoriasis.	Propylthiouracil	65-81	tumor necrosis factor	Homo sapiens	160-169
14711144-0	2003	Effect of PTU on IL-12 and IL-10 in psoriasis.	Propylthiouracil	10-13	interleukin 10	Homo sapiens	27-32
15233577-10	2004	Furthermore, a shift in the developmental GFAP profile was observed in the PTU-treated cerebellum.	Propylthiouracil	75-78	glial fibrillary acidic protein	Rattus norvegicus	42-46
15114849-0	2004	[A case of MPO-ANCA positive vasculitis associated with diffuse alveolar hemorrhage and various cardiac conducting system abnormalities following propylthiouracil treatment].	Propylthiouracil	146-162	myeloperoxidase	Homo sapiens	11-14
14711144-6	2003	The effect of PTU on IL-12 and IL-10 levels was, therefore, studied in twelve patients with plaque psoriasis.	Propylthiouracil	14-17	interleukin 10	Homo sapiens	31-36
14711144-9	2003	IL-10 concentrations were 1.39 +/- 1.49 pg/ml (mean +/- SD) at baseline, and showed no significant change after 2 weeks (1.63 +/- 1.61 pg/ml and 12 weeks 1.15 +/- 1.58 pg/ml of treatment with PTU.	Propylthiouracil	192-195	interleukin 10	Homo sapiens	0-5
12959993-6	2003	TR beta PV mice treated with 6-propyl-2-thiouracil and supplemented with T3 to make them euthyroid have decreased contractility with negative and positive rates of relaxation and contraction as well as peak systolic pressure diminished by 35 +/- 5, 34 +/- 6, and 35 +/- 6% in comparison with WT mice.	Propylthiouracil	29-50	thyroid hormone receptor beta	Mus musculus	0-7
14708556-3	2003	Herein, we describe the case of a 59-year-old woman who developed myeloperoxidase (MPO)- and proteinase 3 (PR3)-ANCA positive DAH, without any other organ system involvement, during PTU therapy.	Propylthiouracil	182-185	myeloperoxidase	Homo sapiens	66-81
14708556-3	2003	Herein, we describe the case of a 59-year-old woman who developed myeloperoxidase (MPO)- and proteinase 3 (PR3)-ANCA positive DAH, without any other organ system involvement, during PTU therapy.	Propylthiouracil	182-185	myeloperoxidase	Homo sapiens	83-86
14708556-3	2003	Herein, we describe the case of a 59-year-old woman who developed myeloperoxidase (MPO)- and proteinase 3 (PR3)-ANCA positive DAH, without any other organ system involvement, during PTU therapy.	Propylthiouracil	182-185	proteinase 3	Homo sapiens	93-105
14708556-3	2003	Herein, we describe the case of a 59-year-old woman who developed myeloperoxidase (MPO)- and proteinase 3 (PR3)-ANCA positive DAH, without any other organ system involvement, during PTU therapy.	Propylthiouracil	182-185	proteinase 3	Homo sapiens	107-110
12922945-8	2003	PTU (12 mM) inhibited the activities of both the cytochrome P450 side-chain cleavage enzyme (P450scc, conversion of 25-hydroxyl cholesterol to pregnenolone) and the 3beta-hydroxysteroid dehydrogenase (conversion of pregnenolone to progesterone) in rat granulosa cells.	Propylthiouracil	0-3	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	49-91
14576819-7	2003	Cyclin D3 protein levels were higher in the thyrocytes from glands of propylthiouracil-treated rats compared with control animals.	Propylthiouracil	70-86	cyclin D3	Rattus norvegicus	0-9
14576819-8	2003	The increase in cyclin D3 expression occurred after the propylthiouracil-induced increase in TSH levels and preceded the burst of cell proliferation.	Propylthiouracil	56-72	cyclin D3	Rattus norvegicus	16-25
12933695-0	2003	Pre- and postnatal propylthiouracil-induced hypothyroidism impairs synaptic transmission and plasticity in area CA1 of the neonatal rat hippocampus.	Propylthiouracil	19-35	carbonic anhydrase 1	Rattus norvegicus	112-115
12922945-8	2003	PTU (12 mM) inhibited the activities of both the cytochrome P450 side-chain cleavage enzyme (P450scc, conversion of 25-hydroxyl cholesterol to pregnenolone) and the 3beta-hydroxysteroid dehydrogenase (conversion of pregnenolone to progesterone) in rat granulosa cells.	Propylthiouracil	0-3	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	93-100
12922945-13	2003	The present results suggest that PTU decreases the progesterone release by granulosa cells via a thyroid-independent mechanism involving the inhibition of post-cAMP pathway, and the activities of intracellular calcium, steroidogenic enzyme, and StAR protein functions.	Propylthiouracil	33-36	steroidogenic acute regulatory protein	Rattus norvegicus	245-249
12834875-4	2003	In vitro and in vivo studies in other biological systems demonstrate that PTU can significantly alter glutathione S-transferase (GST) enzyme expression and activity.	Propylthiouracil	74-77	hematopoietic prostaglandin D synthase	Mus musculus	102-127
12834875-4	2003	In vitro and in vivo studies in other biological systems demonstrate that PTU can significantly alter glutathione S-transferase (GST) enzyme expression and activity.	Propylthiouracil	74-77	hematopoietic prostaglandin D synthase	Mus musculus	129-132
12834875-7	2003	One month treatment with PTU revealed a significant decrease in expression of GST alpha (37%) as identified by Western blot analysis.	Propylthiouracil	25-28	hematopoietic prostaglandin D synthase	Mus musculus	78-81
12834875-10	2003	GST enzyme activity significantly decreased after 1 month of PTU treatment (53%) and remained suppressed, despite the presence of exogenous T(4).	Propylthiouracil	61-64	hematopoietic prostaglandin D synthase	Mus musculus	0-3
12507274-0	2002	A successful pregnancy and delivery case of Graves" disease with myeloperoxidase antineutrophil cytoplasmic antibody induced by propylthiouracil.	Propylthiouracil	128-144	myeloperoxidase	Homo sapiens	65-80
12841851-0	2003	CD1a expression in psoriatic skin following treatment with propylthiouracil, an antithyroid thioureylene.	Propylthiouracil	59-75	CD1a molecule	Homo sapiens	0-4
12841851-3	2003	Since the drugs reduce circulating IL-12 levels in patients with Graves" hyperthyroidism, the effect of propylthiouracil on CD1a expression in psoriatic lesions was examined in biopsy samples of patients with plaque psoriasis.	Propylthiouracil	104-120	CD1a molecule	Homo sapiens	124-128
12755690-3	2003	Decreased H2O2 availability may be another mechanism of inhibition of thyroperoxidase activity produced by thioureylene compounds, as propylthiouracil (PTU) and methimazole (MMI) are antioxidant agents.	Propylthiouracil	134-150	thyroid peroxidase	Homo sapiens	70-85
12755690-3	2003	Decreased H2O2 availability may be another mechanism of inhibition of thyroperoxidase activity produced by thioureylene compounds, as propylthiouracil (PTU) and methimazole (MMI) are antioxidant agents.	Propylthiouracil	152-155	thyroid peroxidase	Homo sapiens	70-85
12755690-11	2003	In conclusion, this study shows that MMI, but not PTU, is able to scavenge H2O2 in the micromolar range and that both PTU and MMI can impair thyroid H2O2 generation in addition to their potent thyroperoxidase inhibitory effects.	Propylthiouracil	118-121	thyroid peroxidase	Homo sapiens	193-208
12857055-0	2003	Propylthiouracil (PTU)-induced vasculitis associated with antineutrophil antibody against myeloperoxidase (MPO-ANCA).	Propylthiouracil	0-16	myeloperoxidase	Homo sapiens	90-105
12857055-0	2003	Propylthiouracil (PTU)-induced vasculitis associated with antineutrophil antibody against myeloperoxidase (MPO-ANCA).	Propylthiouracil	0-16	myeloperoxidase	Homo sapiens	107-110
12857055-0	2003	Propylthiouracil (PTU)-induced vasculitis associated with antineutrophil antibody against myeloperoxidase (MPO-ANCA).	Propylthiouracil	18-21	myeloperoxidase	Homo sapiens	90-105
12857055-0	2003	Propylthiouracil (PTU)-induced vasculitis associated with antineutrophil antibody against myeloperoxidase (MPO-ANCA).	Propylthiouracil	18-21	myeloperoxidase	Homo sapiens	107-110
12857055-3	2003	Antineutrophil cytoplasmic antibody against myeloperoxidase (MPO-ANCA) was positive, and she was diagnosed with PTU-induced vasculitis.	Propylthiouracil	112-115	myeloperoxidase	Homo sapiens	44-59
12857055-3	2003	Antineutrophil cytoplasmic antibody against myeloperoxidase (MPO-ANCA) was positive, and she was diagnosed with PTU-induced vasculitis.	Propylthiouracil	112-115	myeloperoxidase	Homo sapiens	61-64
24387178-1	2003	Abstract A 65-year-old woman with a history of primary biliary cirrhosis was diagnosed as having myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated crescentic glomerulonephritis (GN) during propylthiouracil (PTU) therapy for Graves" disease.	Propylthiouracil	213-229	myeloperoxidase	Homo sapiens	150-153
24387178-1	2003	Abstract A 65-year-old woman with a history of primary biliary cirrhosis was diagnosed as having myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated crescentic glomerulonephritis (GN) during propylthiouracil (PTU) therapy for Graves" disease.	Propylthiouracil	231-234	myeloperoxidase	Homo sapiens	150-153
24387178-4	2003	Withdrawal of PTU and the administration of prednisolone resulted in a decrease in the titer of MPO-ANCA, together with an improvement in renal function.	Propylthiouracil	14-17	myeloperoxidase	Homo sapiens	96-99
12606457-1	2003	The objectives of this study were to determine the effects of propylthiouracil (PTU)-induced neonatal hypothyroidism on the gap junctional protein Cx43 in rat testis and epididymis.	Propylthiouracil	62-78	gap junction protein, alpha 1	Rattus norvegicus	147-151
12606457-1	2003	The objectives of this study were to determine the effects of propylthiouracil (PTU)-induced neonatal hypothyroidism on the gap junctional protein Cx43 in rat testis and epididymis.	Propylthiouracil	80-83	gap junction protein, alpha 1	Rattus norvegicus	147-151
12606457-5	2003	In PTU-treated rats, Cx43 did not localize to the plasma membrane and was still cytoplasmic at 30 days of age.	Propylthiouracil	3-6	gap junction protein, alpha 1	Rattus norvegicus	21-25
12606457-8	2003	In the proximal epididymis (initial segment, caput, corpus), Cx43 mRNA levels were lower in PTU-treated rats at 14, 18, and 22 days of age, but no differences were observed in the distal (cauda) epididymis at these ages.	Propylthiouracil	92-95	gap junction protein, alpha 1	Rattus norvegicus	61-65
12606457-10	2003	In PTU-treated rats, Cx43 was not detectable in initial segment, caput, or corpus epididymidis.	Propylthiouracil	3-6	gap junction protein, alpha 1	Rattus norvegicus	21-25
12606457-11	2003	In the cauda epididymidis, however, Cx43 immunostaining in PTU-treated rats was similar to controls.	Propylthiouracil	59-62	gap junction protein, alpha 1	Rattus norvegicus	36-40
12507274-3	2002	As myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) vasculitis is one of the adverse effects of PTU, we examined serum MPO-ANCA level and found it was positive, but cytoplasmic-ANCA (c-ANCA) was negative.	Propylthiouracil	111-114	myeloperoxidase	Homo sapiens	3-18
12507274-3	2002	As myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) vasculitis is one of the adverse effects of PTU, we examined serum MPO-ANCA level and found it was positive, but cytoplasmic-ANCA (c-ANCA) was negative.	Propylthiouracil	111-114	myeloperoxidase	Homo sapiens	57-60
12507274-3	2002	As myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) vasculitis is one of the adverse effects of PTU, we examined serum MPO-ANCA level and found it was positive, but cytoplasmic-ANCA (c-ANCA) was negative.	Propylthiouracil	111-114	myeloperoxidase	Homo sapiens	134-137
12507274-3	2002	As myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) vasculitis is one of the adverse effects of PTU, we examined serum MPO-ANCA level and found it was positive, but cytoplasmic-ANCA (c-ANCA) was negative.	Propylthiouracil	111-114	proteinase 3	Homo sapiens	180-196
12507274-3	2002	As myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) vasculitis is one of the adverse effects of PTU, we examined serum MPO-ANCA level and found it was positive, but cytoplasmic-ANCA (c-ANCA) was negative.	Propylthiouracil	111-114	proteinase 3	Homo sapiens	190-196
12507274-10	2002	It is necessary to consider the appearance of the possibility of MPO-ANCA positive vasculitis in patients who are treated with PTU.	Propylthiouracil	127-130	myeloperoxidase	Homo sapiens	65-68
11805173-2	2002	Seven Japanese pediatric patients who had myeloperoxidase-specific ANCA-positive biopsy-proven pauci-immune necrotizing crescentic glomerulonephritis associated with propylthiouracil administration were entered in the study.	Propylthiouracil	166-182	myeloperoxidase	Homo sapiens	42-57
12135875-8	2002	PTU inhibited pregnenolone production (i.e., it diminished the function of P450(scc) in Leydig cells).	Propylthiouracil	0-3	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	75-84
12135875-9	2002	In addition to inhibiting hormone secretion, PTU also regulated steroidogenesis by diminishing mRNA expression of StAR.	Propylthiouracil	45-48	steroidogenic acute regulatory protein	Rattus norvegicus	114-118
12135875-10	2002	These results suggest that PTU acts directly on rat Leydig cells to diminish testosterone production by inhibiting P450(scc) function and StAR expression.	Propylthiouracil	27-30	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	115-124
12135875-10	2002	These results suggest that PTU acts directly on rat Leydig cells to diminish testosterone production by inhibiting P450(scc) function and StAR expression.	Propylthiouracil	27-30	steroidogenic acute regulatory protein	Rattus norvegicus	138-142
12201217-0	2002	Prevalence of serum anti-myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) in patients with Graves" disease treated with propylthiouracil and thiamazole.	Propylthiouracil	136-152	myeloperoxidase	Homo sapiens	80-83
12201217-8	2002	Thus, there is a high frequency of MPO-ANCA in patients with Graves" disease treated with PTU, compared with patients treated with MMI, although classical ANCA-associated vasculitis develops in only a few MPO-ANCA positive patients.	Propylthiouracil	90-93	myeloperoxidase	Homo sapiens	35-38
11956877-0	2002	ANCA-positive glomerulonephritis and IgA nephropathy in a patient on propylthiouracil.	Propylthiouracil	69-85	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	37-40
11851085-2	2002	During treatment with propylthiouracil and levothyroxine, the plasma concentrations of thyroid hormone, sex hormones and sex hormone-binding globulin normalised and the gynaecomastia disappeared.	Propylthiouracil	22-38	sex hormone binding globulin	Homo sapiens	121-149
11850121-4	2002	We found that both SRC-1 and N-CoR mRNA levels were decreased in the cortex and dentate gyrus of 6-n-propyl-2 thiouracil treated rats only on P15, while mRNA levels for both genes were increased in the same CA3 region of the brains.	Propylthiouracil	97-120	nuclear receptor coactivator 1	Rattus norvegicus	19-24
11850121-4	2002	We found that both SRC-1 and N-CoR mRNA levels were decreased in the cortex and dentate gyrus of 6-n-propyl-2 thiouracil treated rats only on P15, while mRNA levels for both genes were increased in the same CA3 region of the brains.	Propylthiouracil	97-120	nuclear receptor co-repressor 1	Rattus norvegicus	29-34
12232461-0	2002	Diffuse alveolar hemorrhage associated with myeloperoxidase-antineutrophil cytoplasmic antibody induced by propylthiouracil therapy.	Propylthiouracil	107-123	myeloperoxidase	Homo sapiens	44-59
11822799-12	2002	During weeks 5 and 6 of PTU administration, TSH response to TRH was exaggerated, and thyroid hormone response was blunted.	Propylthiouracil	24-27	thyrotropin releasing hormone	Equus caballus	60-63
11289700-5	2001	Significantly decreased NO and TBARS and increased GSH and CuZn SOD levels were observed in PTU-treated Basedow patients compared to pre-PTU administration.	Propylthiouracil	92-95	superoxide dismutase 1	Homo sapiens	59-67
20428449-1	2001	OBJECTIVES: To determine putative effects of various protocols of propylthiouracil (PTU)-induced hypothyroidism on vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) levels in the atria of developing and adult female rats.	Propylthiouracil	66-82	vasoactive intestinal peptide	Rattus norvegicus	115-148
20428449-1	2001	OBJECTIVES: To determine putative effects of various protocols of propylthiouracil (PTU)-induced hypothyroidism on vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) levels in the atria of developing and adult female rats.	Propylthiouracil	66-82	vasoactive intestinal peptide	Rattus norvegicus	172-175
20428449-1	2001	OBJECTIVES: To determine putative effects of various protocols of propylthiouracil (PTU)-induced hypothyroidism on vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) levels in the atria of developing and adult female rats.	Propylthiouracil	84-87	vasoactive intestinal peptide	Rattus norvegicus	115-148
20428449-9	2001	Thyroid hormone deficiency led to a significant increase in VIP-LI levels in both atria of PTU-30 and PTU-70 rats (P<0.01 versus corresponding controls).	Propylthiouracil	91-94	vasoactive intestinal peptide	Rattus norvegicus	60-63
20428449-9	2001	Thyroid hormone deficiency led to a significant increase in VIP-LI levels in both atria of PTU-30 and PTU-70 rats (P<0.01 versus corresponding controls).	Propylthiouracil	102-105	vasoactive intestinal peptide	Rattus norvegicus	60-63
20428449-10	2001	Interestingly, in P-PTU atria, VIP-LI reached significantly higher values than in rats treated with PTU for the same time during adulthood (PTU-70).	Propylthiouracil	20-23	vasoactive intestinal peptide	Rattus norvegicus	31-34
11878166-5	2001	A 20-year-old female patient developed an elevation of AST, ALT and GGT levels after 5 months of PTU (50 mg tid) therapy for Graves disease with hyperthyroidism.	Propylthiouracil	97-100	solute carrier family 17 member 5	Homo sapiens	55-58
11878166-5	2001	A 20-year-old female patient developed an elevation of AST, ALT and GGT levels after 5 months of PTU (50 mg tid) therapy for Graves disease with hyperthyroidism.	Propylthiouracil	97-100	gamma-glutamyltransferase light chain 5 pseudogene	Homo sapiens	68-71
11401533-1	2001	Two established antithyroid drugs, 6-propyl-2-thiouracil and 6-methyl-2-thiouracil, as well as S-methylthiouracil, are shown to be competitive inhibitors of nitric oxide synthase (NOS) (K(I) values ranging from 14 to 60 microM), with moderate selectivity for the neuronal isoform.	Propylthiouracil	35-56	nitric oxide synthase 2	Homo sapiens	157-178
11598378-4	2001	Using GH mRNA as an end point, we demonstrate that in hyperthyroid states GH mRNA levels are stimulated by triiodothyronine (T(3)) generated via D1, whereas in hypothyroidism, when D2 activity is markedly increased, GH mRNA is more responsive to tetraiodothyronine (T(4)) in a propylthiouracil-insensitive, reverse T(3)-suppressible manner.	Propylthiouracil	277-293	growth hormone 1	Homo sapiens	74-76
11598378-4	2001	Using GH mRNA as an end point, we demonstrate that in hyperthyroid states GH mRNA levels are stimulated by triiodothyronine (T(3)) generated via D1, whereas in hypothyroidism, when D2 activity is markedly increased, GH mRNA is more responsive to tetraiodothyronine (T(4)) in a propylthiouracil-insensitive, reverse T(3)-suppressible manner.	Propylthiouracil	277-293	growth hormone 1	Homo sapiens	74-76
11425850-4	2001	Mesothelioma cell lysates activate thyroxine (T(4)) to 3,5,3"-triiodothyronine with typical characteristics of D2 such as low K(m) (T(4)), 1.3 nm, resistance to propylthiouracil, and a short half-life ( approximately 30 min).	Propylthiouracil	161-177	iodothyronine deiodinase 2	Homo sapiens	111-113
11422030-0	2001	Effect of propylthiouracil on adenosine deaminase activity and thyroid function in patients with psoriasis.	Propylthiouracil	10-26	adenosine deaminase	Homo sapiens	30-49
11422030-3	2001	OBJECTIVES: To investigate whether ADA activity may be related to psoriasis and whether oral PTU affects ADA activity and gives clinical improvement in psoriatic patients.	Propylthiouracil	93-96	adenosine deaminase	Homo sapiens	105-108
11380496-0	2001	Frequency of appearance of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) in Graves" disease patients treated with propylthiouracil and the relationship between MPO-ANCA and clinical manifestations.	Propylthiouracil	131-147	myeloperoxidase	Homo sapiens	27-42
11380496-0	2001	Frequency of appearance of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) in Graves" disease patients treated with propylthiouracil and the relationship between MPO-ANCA and clinical manifestations.	Propylthiouracil	131-147	myeloperoxidase	Homo sapiens	80-83
11380496-1	2001	OBJECTIVE: Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-positive vasculitis has been reported in patients with Graves" disease who were treated with propylthiouracil (PTU).	Propylthiouracil	167-183	myeloperoxidase	Homo sapiens	11-26
11380496-1	2001	OBJECTIVE: Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-positive vasculitis has been reported in patients with Graves" disease who were treated with propylthiouracil (PTU).	Propylthiouracil	167-183	myeloperoxidase	Homo sapiens	64-67
11380496-1	2001	OBJECTIVE: Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-positive vasculitis has been reported in patients with Graves" disease who were treated with propylthiouracil (PTU).	Propylthiouracil	185-188	myeloperoxidase	Homo sapiens	11-26
11380496-1	2001	OBJECTIVE: Myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA)-positive vasculitis has been reported in patients with Graves" disease who were treated with propylthiouracil (PTU).	Propylthiouracil	185-188	myeloperoxidase	Homo sapiens	64-67
11380496-11	2001	Three (4.1%) of the 73 patients were positive for MPO-ANCA at 13, 16 and 17 months, respectively, after the start of PTU therapy.	Propylthiouracil	117-120	myeloperoxidase	Homo sapiens	50-53
11440272-4	2001	Propylthiouracil (PTU)-treated hypothyroid rats showed a significant increase in AchE and Mg2+-ATPase activity compared to euthyroid rats.	Propylthiouracil	0-16	acetylcholinesterase	Rattus norvegicus	81-85
11440272-4	2001	Propylthiouracil (PTU)-treated hypothyroid rats showed a significant increase in AchE and Mg2+-ATPase activity compared to euthyroid rats.	Propylthiouracil	18-21	acetylcholinesterase	Rattus norvegicus	81-85
11289700-6	2001	PTU-treated patients compared to controls still exhibited significantly higher T3 and lower TSH values and higher NO, TBARS, GSH, and CuZn SOD levels.	Propylthiouracil	0-3	superoxide dismutase 1	Homo sapiens	134-142
11027843-5	2000	Control and PTU-treated pups were sacrificed on postnatal day (P) 7, 10 and 14, and IGF-I mRNA expression was assessed in the cerebral cortex and cerebellum by ribonuclease protection assay.	Propylthiouracil	12-15	insulin-like growth factor 1	Mus musculus	84-89
11120670-2	2001	In this study, we demonstrated that 6-n-propyl-2-thiouracil (PTU)-induced hypothyroidism stimulated, whereas triido-L-thyronine (T(3))-induced hyperthyroidism suppressed, PC1 mRNA levels in the rat anterior pituitary.	Propylthiouracil	36-59	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	171-174
11120670-2	2001	In this study, we demonstrated that 6-n-propyl-2-thiouracil (PTU)-induced hypothyroidism stimulated, whereas triido-L-thyronine (T(3))-induced hyperthyroidism suppressed, PC1 mRNA levels in the rat anterior pituitary.	Propylthiouracil	61-64	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	171-174
11250767-7	2001	A literature review revealed no prior reports of pericarditis in anti-MPO pANCA-positive vasculitis associated with propylthio- uracil therapy.	Propylthiouracil	116-134	myeloperoxidase	Homo sapiens	70-73
11095466-6	2000	MPO-ANCA was positive in 6.7% of patients before treatment and in 64.0% of those treated with PTU and in none of those treated with methimazole.	Propylthiouracil	94-97	myeloperoxidase	Homo sapiens	0-3
11095466-8	2000	These findings show the high prevalence of the MPO-ANCA positivity in PTU-treated childhood onset Graves" disease, suggesting that PTU may not be preferred as the first line for the treatment of children with Graves" disease.	Propylthiouracil	70-73	myeloperoxidase	Homo sapiens	47-50
11041460-3	2000	The serum IL-18 levels in Graves" disease were significantly increased in the hyperthyroid state and were decreased during treatment with methimazole or propylthiouracil.	Propylthiouracil	153-169	interleukin 18	Homo sapiens	10-15
12114826-1	2000	We examined by immunohistochemistry the expression of 200-kDa (NF-H) neurofilaments in pituitary thyrotrophs of rats, made hypothyroid by propylthiouracil (PTU) administration.	Propylthiouracil	138-154	neurofilament heavy chain	Rattus norvegicus	63-67
10928947-7	2000	The results suggest that the inhibitory actions of PTU on testosterone secretion are exerted, at least in part, at the testicular level through a mechanism which is independent of thyroid status and which involves a reduction in P450scc activity and, hence, in the conversion of cholesterol to pregnenolone.	Propylthiouracil	51-54	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	229-236
12114826-1	2000	We examined by immunohistochemistry the expression of 200-kDa (NF-H) neurofilaments in pituitary thyrotrophs of rats, made hypothyroid by propylthiouracil (PTU) administration.	Propylthiouracil	156-159	neurofilament heavy chain	Rattus norvegicus	63-67
12114826-7	2000	Discontinuation of PTU treatment led to recovery from cytologic alterations in the thyroidectomy cells expressing NF-H.	Propylthiouracil	19-22	neurofilament heavy chain	Rattus norvegicus	114-118
10994694-11	2000	The inhibitory mechanism of PTU on testosterone production involves a decreased activity of 17beta-hydroxysteroid dehydrogenase (17beta-HSD) and post-cAMP pathways.	Propylthiouracil	28-31	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	92-127
10994694-11	2000	The inhibitory mechanism of PTU on testosterone production involves a decreased activity of 17beta-hydroxysteroid dehydrogenase (17beta-HSD) and post-cAMP pathways.	Propylthiouracil	28-31	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	129-139
10804232-9	2000	Finally, we found that the effects of handling on NGFI-A and AP-2 expression were significantly reduced by concurrent treatment with either PTU or ketanserin, effects that paralleled those on cAMP formation.	Propylthiouracil	140-143	early growth response 1	Rattus norvegicus	50-56
10958312-7	2000	However, MPO-ANCA was detected in 21 (37.5%) of 56 patients treated with PTU therapy.	Propylthiouracil	73-76	myeloperoxidase	Homo sapiens	9-12
10958312-8	2000	Furthermore, two patients who were negative for MPO-ANCA became positive after PTU therapy.	Propylthiouracil	79-82	myeloperoxidase	Homo sapiens	48-51
10958312-9	2000	The proportion of patients positive for MPO-ANCA increased with the prolongation of PTU therapy, but did not correlate with age, gender, and positive antithyroperoxidase (TPO) antibody.	Propylthiouracil	84-87	myeloperoxidase	Homo sapiens	40-43
10804232-9	2000	Finally, we found that the effects of handling on NGFI-A and AP-2 expression were significantly reduced by concurrent treatment with either PTU or ketanserin, effects that paralleled those on cAMP formation.	Propylthiouracil	140-143	transcription factor AP-2 alpha	Rattus norvegicus	61-65
10792251-0	2000	Myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis following propylthiouracil therapy.	Propylthiouracil	84-100	myeloperoxidase	Homo sapiens	0-15
10845190-6	2000	Drastic increase in TSH level was observed in the PTU-treated group together with significant decreases in serum thyroid hormone levels and an increase in hepatic UDPGT activity.	Propylthiouracil	50-53	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	163-168
10766242-6	2000	Another TRB gene is found on a human contig assigned to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil in humans.	Propylthiouracil	163-186	T cell receptor beta locus	Homo sapiens	8-11
10749830-0	2000	Fiber-type-specific alphaB-crystallin distribution and its shifts with T(3) and PTU treatments in rat hindlimb muscles.	Propylthiouracil	80-83	crystallin, alpha B	Rattus norvegicus	20-37
10749830-3	2000	alphaB-crystallin content in both soleus and EDL muscles was significantly decreased after T(3), and that in EDL was significantly increased over twofold after PTU treatment.	Propylthiouracil	160-163	crystallin, alpha B	Rattus norvegicus	0-17
10749830-7	2000	Under hypothyroidism conditions with PTU, the mean alphaB-crystallin levels of type IIa and IIx fibers were significantly lower than levels under control conditions.	Propylthiouracil	37-40	crystallin, alpha B	Rattus norvegicus	51-68
10846402-0	2000	[Myeloperoxidase-antineutrophil cytoplasmic antibody positive alveolar hemorrhage during propylthiouracil therapy for hyperthyroidism].	Propylthiouracil	89-105	myeloperoxidase	Homo sapiens	1-16
10804735-0	2000	Myeloperoxidase antineutrophil cytoplasmic antibody positive vasculitis during propylthiouracil treatment: successful management with oral corticosteroids.	Propylthiouracil	79-95	myeloperoxidase	Homo sapiens	0-15
10693882-13	2000	CONCLUSION: These data suggest that a sizable proportion of cases of APV with high titers of anti-MPO antibodies are drug-associated, especially following exposure to hydralazine or propylthiouracil.	Propylthiouracil	182-198	myeloperoxidase	Homo sapiens	98-101
10482376-9	1999	In additon, NIS RNA steady-state levels were decreased by approximately 50% after treatment of monolayers with methimazole, PTU, and potassium iodide, respectively.	Propylthiouracil	124-127	solute carrier family 5 member 5	Rattus norvegicus	12-15
10718548-1	2000	Previously, we observed that excess iodide rapidly suppressed the elevated ornithine decarboxylase activity in the thyroid of propylthiouracil (PTU)-pretreated rats.	Propylthiouracil	126-142	ornithine decarboxylase 1	Rattus norvegicus	75-98
10718548-1	2000	Previously, we observed that excess iodide rapidly suppressed the elevated ornithine decarboxylase activity in the thyroid of propylthiouracil (PTU)-pretreated rats.	Propylthiouracil	144-147	ornithine decarboxylase 1	Rattus norvegicus	75-98
10706002-7	1999	The induction of congenital hypothyroidism by propylthiouracil (PTU) had no effect on gammaGT in N/G PM but effected a one third reduction in the activity of gammaGT in MV.	Propylthiouracil	46-62	gamma-glutamyltransferase 1	Rattus norvegicus	158-165
10706002-7	1999	The induction of congenital hypothyroidism by propylthiouracil (PTU) had no effect on gammaGT in N/G PM but effected a one third reduction in the activity of gammaGT in MV.	Propylthiouracil	64-67	gamma-glutamyltransferase 1	Rattus norvegicus	158-165
10369449-4	1999	In addition, expression of nitric oxide synthase (NOS) was analysed in sections of aorta from PTU-treated and control rats using rabbit polyclonal antibodies to both inducible NOS (iNOS) and endothelial NOS (eNOS).	Propylthiouracil	94-97	nitric oxide synthase 2	Rattus norvegicus	166-179
10695110-0	1999	The use of recombinant human G-CSF in the treatment of propylthiouracil-induced agranulocytosis.	Propylthiouracil	55-71	colony stimulating factor 3	Homo sapiens	29-34
10695110-4	1999	We think that in patients with propylthiouracil-induced agranulocytosis, G-CSF will reduce the risk and severity of infection, and should be accepted as a part of the standard therapy.	Propylthiouracil	31-47	colony stimulating factor 3	Homo sapiens	73-78
10366416-4	1999	In vivo results showed that the steady-state level of thymosin beta10 mRNA is up-regulated in the thyroid gland of propylthiouracil-fed rats in parallel with follicular cell proliferation: iodide administration to goitrous rats, which induced a marked involution of thyroid hyperplasia, reduced the mRNA level of thymosin beta10.	Propylthiouracil	115-131	thymosin, beta 10	Rattus norvegicus	54-69
10366416-4	1999	In vivo results showed that the steady-state level of thymosin beta10 mRNA is up-regulated in the thyroid gland of propylthiouracil-fed rats in parallel with follicular cell proliferation: iodide administration to goitrous rats, which induced a marked involution of thyroid hyperplasia, reduced the mRNA level of thymosin beta10.	Propylthiouracil	115-131	thymosin, beta 10	Rattus norvegicus	313-328
10403658-4	1999	In addition, treatment with classical goitrogenic compounds, such as propylthiouracil (PTU) and methimazole (MMI), induces TGF-beta1 in thyroid-follicular cells, presumably through increased TSH.	Propylthiouracil	69-85	transforming growth factor, beta 1	Rattus norvegicus	123-132
10403658-4	1999	In addition, treatment with classical goitrogenic compounds, such as propylthiouracil (PTU) and methimazole (MMI), induces TGF-beta1 in thyroid-follicular cells, presumably through increased TSH.	Propylthiouracil	87-90	transforming growth factor, beta 1	Rattus norvegicus	123-132
10403658-10	1999	In this study, PTU treatment increased apoptosis and TGF-beta1 immunoreactive thyroid-follicular cells.	Propylthiouracil	15-18	transforming growth factor, beta 1	Rattus norvegicus	53-62
10403658-11	1999	PTU treatment of rats produced both a large increase number of TGF-beta1-positive cells (detected by immunohistochemistry), and apoptotic thyroid-follicular cells (detected by morphology).	Propylthiouracil	0-3	transforming growth factor, beta 1	Rattus norvegicus	63-72
10480451-9	1999	Post-treatment CAT activity was decreased (p < 0.05 in the PTU group, p < 0.001 in the other two groups).	Propylthiouracil	62-65	catalase	Homo sapiens	15-18
10025935-1	1999	We describe a patient who presented with Wegener"s granulomatosis associated with antineutrophil cytoplasmic antibodies (ANCA) directed against proteinase 3 (PR3) with a cytoplasmic immunofluorescence pattern (cANCA), whose ANCA type changed to antimyeloperoxidase antibodies with a perinuclear immunofluorescence pattern (pANCA) when treated with propylthiouracil, and changed back to anti-PR3 antibodies with cANCA after the medication was discontinued.	Propylthiouracil	348-364	proteinase 3	Homo sapiens	144-156
10365684-1	1999	Methimazole (MMI) and propylthiouracil (PTU) are common antithyroid drugs for treating hyperthyroidism because the 2 drugs inhibit thyroid peroxidase (TPO)-catalyzed thyroid hormone formation.	Propylthiouracil	22-38	thyroid peroxidase	Homo sapiens	151-154
10365684-1	1999	Methimazole (MMI) and propylthiouracil (PTU) are common antithyroid drugs for treating hyperthyroidism because the 2 drugs inhibit thyroid peroxidase (TPO)-catalyzed thyroid hormone formation.	Propylthiouracil	40-43	thyroid peroxidase	Homo sapiens	151-154
10365684-6	1999	Exposure to MMI (1 microM and 10 microM) or PTU (10 microM and 100 microM) for 2 days caused a significant increase in cellular TPO activity; 100 microM MMI inhibited cellular TPO activity.	Propylthiouracil	44-47	thyroid peroxidase	Homo sapiens	128-131
10365684-6	1999	Exposure to MMI (1 microM and 10 microM) or PTU (10 microM and 100 microM) for 2 days caused a significant increase in cellular TPO activity; 100 microM MMI inhibited cellular TPO activity.	Propylthiouracil	44-47	thyroid peroxidase	Homo sapiens	176-179
10319936-2	1999	We studied the thyroids of Wistar rats treated with thyroxine (T4) or propylthiouracil (PTU), each of which modulates TSH levels, but affects follicular function and Tg accumulation in the follicular lumen very differently.	Propylthiouracil	70-86	thyroglobulin	Rattus norvegicus	166-168
10319936-2	1999	We studied the thyroids of Wistar rats treated with thyroxine (T4) or propylthiouracil (PTU), each of which modulates TSH levels, but affects follicular function and Tg accumulation in the follicular lumen very differently.	Propylthiouracil	88-91	thyroglobulin	Rattus norvegicus	166-168
10096735-5	1999	PTU therapy caused a relief in oxidative stress as reflected by significantly decreased TBARS levels (P < 0.001) and a selective modification in the antioxidant status parameters: significant decreases in GSH and CuZn SOD levels (P < 0.001) and a significant increase in GSH Px (P < 0.01) activity.	Propylthiouracil	0-3	superoxide dismutase 1	Homo sapiens	216-224
10025935-1	1999	We describe a patient who presented with Wegener"s granulomatosis associated with antineutrophil cytoplasmic antibodies (ANCA) directed against proteinase 3 (PR3) with a cytoplasmic immunofluorescence pattern (cANCA), whose ANCA type changed to antimyeloperoxidase antibodies with a perinuclear immunofluorescence pattern (pANCA) when treated with propylthiouracil, and changed back to anti-PR3 antibodies with cANCA after the medication was discontinued.	Propylthiouracil	348-364	proteinase 3	Homo sapiens	158-161
9618427-7	1998	In the present study myeloperoxidase activity was inhibited fully at therapeutic concentrations by antithyroid drugs (propylthiouracil and methimazole).	Propylthiouracil	118-134	myeloperoxidase	Homo sapiens	21-36
9887092-11	1999	These results demonstrate that PTU-induced hypothyroidism decreases sodium-sulfate cotransport by downregulation of the NaSi-1 gene.	Propylthiouracil	31-34	solute carrier family 13 member 1	Rattus norvegicus	120-126
9720771-2	1998	The purpose of the present study was to test the following hypothesis: propylthiouracil (PTU) treatments of rats induces an increase in the concentration and activity of the mitochondrial ATPase (m-ATPase) inhibitor protein (IF1).	Propylthiouracil	71-87	ATP synthase inhibitory factor subunit 1	Rattus norvegicus	225-228
9720771-2	1998	The purpose of the present study was to test the following hypothesis: propylthiouracil (PTU) treatments of rats induces an increase in the concentration and activity of the mitochondrial ATPase (m-ATPase) inhibitor protein (IF1).	Propylthiouracil	89-92	ATP synthase inhibitory factor subunit 1	Rattus norvegicus	225-228
9720771-8	1998	Propylthiouracil pretreatment for 12 days enhanced the concentration of the following metabolites in the liver: ATP (1.5 fold), ATPase inhibitor protein (IF1) (4.5 fold), and reduced glutathione (1.3 fold), while the activity of the inhibitor protein increased 2 fold.	Propylthiouracil	0-16	ATP synthase inhibitory factor subunit 1	Rattus norvegicus	154-157
9299608-7	1997	Differences between controls and groups exposed to PCB 77 or PTU were detected in a blocking test using the mixed serotonin 5-HT1A agonist and partial D2 antagonist buspirone.	Propylthiouracil	61-64	5-hydroxytryptamine receptor 1A	Rattus norvegicus	124-130
9603244-6	1998	The disappearance of fibulin-2 and the BM-association of collagen VI were both delayed in the PTU-treated testes.	Propylthiouracil	94-97	fibulin 2	Rattus norvegicus	21-30
9270719-5	1997	Similarly, propylthiouracil and aminotriazole, inhibitors of peroxidase, abolish both effects of PRL.	Propylthiouracil	11-27	prolactin	Mus musculus	97-100
9564842-6	1998	During cerebellar development, an approximately 3-fold increase in the cerebellar content of ROR alpha messenger RNA (mRNA) was seen in both propylthiouracil-treated, and propylthiouracil-treated and T4-replaced animals.	Propylthiouracil	141-157	RAR-related orphan receptor A	Rattus norvegicus	93-102
9564842-6	1998	During cerebellar development, an approximately 3-fold increase in the cerebellar content of ROR alpha messenger RNA (mRNA) was seen in both propylthiouracil-treated, and propylthiouracil-treated and T4-replaced animals.	Propylthiouracil	171-187	RAR-related orphan receptor A	Rattus norvegicus	93-102
10074786-5	1998	We have previously shown that chronic ingestion of 6-n-propyl-2-thiouracil (PTU), while not affecting plasma osmolality or VP mRNA size, results in a significant increase in the abundance of the hypothalamic VP mRNA.	Propylthiouracil	51-74	arginine vasopressin	Rattus norvegicus	208-210
10074786-5	1998	We have previously shown that chronic ingestion of 6-n-propyl-2-thiouracil (PTU), while not affecting plasma osmolality or VP mRNA size, results in a significant increase in the abundance of the hypothalamic VP mRNA.	Propylthiouracil	76-79	arginine vasopressin	Rattus norvegicus	208-210
10074786-6	1998	We now show that chronic PTU ingestion results in a dramatic increase in the abundance of the mRNA encoded by a modified rat vasopressin transgene that is expressed in rat vasopressinergic magnocellular neurons.	Propylthiouracil	25-28	arginine vasopressin	Rattus norvegicus	125-136
9389495-0	1997	Characterization of a propylthiouracil-insensitive type I iodothyronine deiodinase.	Propylthiouracil	22-38	iodothyronine deiodinase 1	Homo sapiens	51-82
9389495-1	1997	Mammalian type I iodothyronine deiodinase (D1) activates and inactivates thyroid hormone by outer ring deiodination (ORD) and inner ring deiodination (IRD), respectively, and is potently inhibited by propylthiouracil (PTU).	Propylthiouracil	200-216	iodothyronine deiodinase 1	Homo sapiens	10-41
9389495-1	1997	Mammalian type I iodothyronine deiodinase (D1) activates and inactivates thyroid hormone by outer ring deiodination (ORD) and inner ring deiodination (IRD), respectively, and is potently inhibited by propylthiouracil (PTU).	Propylthiouracil	218-221	iodothyronine deiodinase 1	Homo sapiens	10-41
9492566-0	1997	[MPO-ANCA related vasculitis with pulmonary hemorrhage during propylthiouracil (PTU) therapy].	Propylthiouracil	62-78	myeloperoxidase	Homo sapiens	1-4
9492566-0	1997	[MPO-ANCA related vasculitis with pulmonary hemorrhage during propylthiouracil (PTU) therapy].	Propylthiouracil	80-83	myeloperoxidase	Homo sapiens	1-4
9390004-6	1997	In experiments designed to alter the thyroid hormone status in animals it was demonstrated that both the reporter gene and the endogenous CRABP-I expression were reduced by triiodothyronine injection and were elevated in a hypothyroidic condition induced by feeding with iodine-deficient diet supplemented with 6-propyl-2-thiouracil.	Propylthiouracil	311-332	cellular retinoic acid binding protein I	Mus musculus	138-145
9284751-6	1997	Clearances (mL.min-1.g-1, means +/- SD) of PTU from maternal to fetal circuits were: 0.229 +/- 0.110, 0.216 +/- 0.065, and 0.170 +/- 0.032; and for transfer of MMI: 0.165 +/- 0.025, 0.232 +/- 0.153, and 0.174 +/- 0.009 (for low doses without, low doses with, and high doses without albumin, respectively).	Propylthiouracil	43-46	CD59 molecule (CD59 blood group)	Homo sapiens	15-20
8947614-0	1996	Antibodies to myeloperoxidase in propylthiouracil-induced autoimmune disease in the cat.	Propylthiouracil	33-49	myeloperoxidase	Felis catus	14-29
9192950-5	1997	Alveolar haemorrhage or pulmonary-renal syndrome associated with antineutrophil cytoplasmic antibody with myeloperoxidase specificity may be a new complication of propylthiouracil therapy.	Propylthiouracil	163-179	myeloperoxidase	Homo sapiens	106-121
9134835-0	1997	[A case of Grave"s disease with MPO-ANCA-associated glomerulonephritis during propylthiouracil (PTU) therapy following interstitial pneumonitis].	Propylthiouracil	78-94	myeloperoxidase	Homo sapiens	32-35
9134835-0	1997	[A case of Grave"s disease with MPO-ANCA-associated glomerulonephritis during propylthiouracil (PTU) therapy following interstitial pneumonitis].	Propylthiouracil	96-99	myeloperoxidase	Homo sapiens	32-35
9134835-1	1997	A 68-year-old man who developed MPO-ANCA-associated glomerulonephritis during propylthiouracil (PTU) treatment is reported.	Propylthiouracil	78-94	myeloperoxidase	Homo sapiens	32-35
9134835-1	1997	A 68-year-old man who developed MPO-ANCA-associated glomerulonephritis during propylthiouracil (PTU) treatment is reported.	Propylthiouracil	96-99	myeloperoxidase	Homo sapiens	32-35
9134835-12	1997	Polyclonal B-cell activation and PTU treatment may have played a role in the pathogenesis of MPO-ANCA-associated glomerulonephritis.	Propylthiouracil	33-36	myeloperoxidase	Homo sapiens	93-96
9116149-4	1997	In contrast to controls, PA and gelatinase A activities were maintained through puberty (42 days) in PTU-treated rats but declined by 90 days.	Propylthiouracil	101-104	matrix metallopeptidase 2	Rattus norvegicus	32-44
12114793-0	1997	Effects of Propyithiouracil (PTU) Administration on the Synthesis and Secretion of Thyroglobulin in the Rat Thyroid Gland: A Quantitative Immuno-electron Microscopic Study Using Immunogold Technique.	Propylthiouracil	29-32	thyroglobulin	Rattus norvegicus	83-96
9283219-1	1997	We have experienced a case of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-related glomerulonephritis induced by propylthiouracil (PTU).	Propylthiouracil	131-147	myeloperoxidase	Homo sapiens	83-86
9283219-1	1997	We have experienced a case of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-related glomerulonephritis induced by propylthiouracil (PTU).	Propylthiouracil	149-152	myeloperoxidase	Homo sapiens	83-86
9283219-9	1997	Although steroid therapy effectively responded to their renal function without the withdrawal of PTU, it seems that PTU may be closely associated with the development of (MPO-ANCA)-related glomerulonephritis in this case.	Propylthiouracil	116-119	myeloperoxidase	Homo sapiens	171-174
9146773-11	1997	Pre-treatment with either methimazole 0.04% or propylthiouracil 0.01% significantly decreased mucosal damage macroscopically (lesion area, lesion score and segmental weight) microscopically and also significantly decreased MPO level at both time points (P < 0.01).	Propylthiouracil	47-63	myeloperoxidase	Rattus norvegicus	223-226
8977411-5	1997	The high rT3-K(m) type I 5"-deiodinase activity (180 nM) has a low cofactor requirement (5 mM dithiothreitol) and is relatively sensitive to propylthiouracil inhibition, whereas the low rT3-K(m) activity was akin to the outer ring deiodination of T4 in these regards.	Propylthiouracil	141-157	iodothyronine deiodinase 1	Homo sapiens	18-38
8947614-2	1996	We have previously demonstrated that propylthiouracil and other drugs associated with lupus are oxidized in the presence of myeloperoxidase to reactive intermediates.	Propylthiouracil	37-53	myeloperoxidase	Felis catus	124-139
8892315-0	1996	Decreased growth rate and tumour formation of human anaplastic thyroid carcinoma cells transfected with a human thyrotropin receptor cDNA in NMRI nude mice treated with propylthiouracil.	Propylthiouracil	169-185	thyroid stimulating hormone receptor	Homo sapiens	112-132
8764561-2	1996	In vitro experiments have established that myeloperoxidase of activated neutrophils can oxidize PTU to the reactive intermediate propyluracil 2-sulfonate PTU-SO3-, and it has been proposed that PTU-SO3- might be responsible for the PTU-associated side effects.	Propylthiouracil	96-99	myeloperoxidase	Mus musculus	43-58
8764561-2	1996	In vitro experiments have established that myeloperoxidase of activated neutrophils can oxidize PTU to the reactive intermediate propyluracil 2-sulfonate PTU-SO3-, and it has been proposed that PTU-SO3- might be responsible for the PTU-associated side effects.	Propylthiouracil	154-157	myeloperoxidase	Mus musculus	43-58
8764561-3	1996	Here, using the direct popliteal lymph node assay (PLNA) in mice we found that PTU-SO3-, indeed, induced a T-cell-dependent primary PLN response, whereas the parent compound PTU failed to do so.	Propylthiouracil	79-82	phospholamban	Mus musculus	51-54
8882155-0	1996	Acute inhibitory effect of excess iodide on ornithine decarboxylase in the thyroid of propylthiouracil-treated rats.	Propylthiouracil	86-102	ornithine decarboxylase 1	Rattus norvegicus	44-67
8882155-4	1996	Thyroidal ODC activity, protein content and mRNA were increased in rats made hypothyroid by 10 days of propylthiouracil treatment.	Propylthiouracil	103-119	ornithine decarboxylase 1	Rattus norvegicus	10-13
8616538-10	1996	Gene expression of TGF-beta1 was induced in TSH- and PTU-treated rats.	Propylthiouracil	53-56	transforming growth factor, beta 1	Rattus norvegicus	19-28
8783290-0	1996	Propylthiouracil treatment reduces long-term potentiation in area CA1 of neonatal rat hippocampus.	Propylthiouracil	0-16	carbonic anhydrase 1	Rattus norvegicus	66-69
8886628-0	1996	Blockade of the estrogen induced increase in progesterone receptor caused by propylthiouracil, an anti-thyroid drug, in a transplantable pituitary tumor in rats.	Propylthiouracil	77-93	progesterone receptor	Rattus norvegicus	45-66
8886628-4	1996	When the host rats were treated with propylthiouracil (PTU), an anti-thyroid drug, the induction of PR after an E2 injection was completely blocked.	Propylthiouracil	37-53	progesterone receptor	Rattus norvegicus	100-102
8886628-4	1996	When the host rats were treated with propylthiouracil (PTU), an anti-thyroid drug, the induction of PR after an E2 injection was completely blocked.	Propylthiouracil	55-58	progesterone receptor	Rattus norvegicus	100-102
8886628-10	1996	Our findings suggest that PTU lower the ER level and suppresses the short term estrogenic actions such as PR induction after an E2 injection.	Propylthiouracil	26-29	progesterone receptor	Rattus norvegicus	106-108
8737671-4	1996	However, the expression of c-fos mRNA was comparable in neocortex, dorsal hippocampus and medial geniculate body between control rats and PTU-treated, seizure-induced rats.	Propylthiouracil	138-141	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-32
8616538-14	1996	In conclusion, TGF-beta1 is produced in response to both a direct (TSH by itself) and indirect (TSH induced by PTU-induced hypothyroidism) cellular proliferative stimulus and is not linked to an adaptative phenomenon secondary to hypothyroidism.	Propylthiouracil	111-114	transforming growth factor, beta 1	Rattus norvegicus	15-24
7790147-2	1995	METHOD: The effect of oral treatment with 6-n-propyl 2-thiouracil (propylthiouracil, PTU) and 2-mercapto 1-methyl imidazole (methimazole, MMI) on proliferating cell nuclear antigen (PCNA), and p53 protein expression was studied in patients with stable plaque psoriasis.	Propylthiouracil	42-65	proliferating cell nuclear antigen	Homo sapiens	146-180
7788003-0	1995	Serum levels of interleukin 6 and tumor necrosis factor-alpha in hyperthyroid patients before and after propylthiouracil treatment.	Propylthiouracil	104-120	interleukin 6	Homo sapiens	16-61
7790147-2	1995	METHOD: The effect of oral treatment with 6-n-propyl 2-thiouracil (propylthiouracil, PTU) and 2-mercapto 1-methyl imidazole (methimazole, MMI) on proliferating cell nuclear antigen (PCNA), and p53 protein expression was studied in patients with stable plaque psoriasis.	Propylthiouracil	42-65	proliferating cell nuclear antigen	Homo sapiens	182-186
7576492-1	1995	Hypothyroidism (induced by 8 weeks of oral 0.05% propylthiouracil) heightened the phenotype of mdx mouse dystrophin-deficient myopathy to more closely resemble human Duchenne muscular dystrophy.	Propylthiouracil	49-65	dystrophin, muscular dystrophy	Mus musculus	105-115
7741770-0	1995	Effect of propylthiouracil treatment on NADPH-cytochrome P450 reductase levels, oxygen consumption and hydroxyl radical formation in liver microsomes from rats fed ethanol or acetone chronically.	Propylthiouracil	10-26	cytochrome p450 oxidoreductase	Rattus norvegicus	40-71
7741770-6	1995	Administration of PTU (25 mg/kg/day) to ethanol- or acetone-fed rats, for 10 and 14 days, respectively, led to a marked reduction in the levels and activity of CYP-reductase, and to a decrease in the rates of microsomal O2 consumption, .OH production and ethanol oxidation, but did not lower the levels of CYP2E1 or the metabolism of the CYP2E1 substrate N,N-nitrosodimethylamine.	Propylthiouracil	18-21	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	306-312
7741770-6	1995	Administration of PTU (25 mg/kg/day) to ethanol- or acetone-fed rats, for 10 and 14 days, respectively, led to a marked reduction in the levels and activity of CYP-reductase, and to a decrease in the rates of microsomal O2 consumption, .OH production and ethanol oxidation, but did not lower the levels of CYP2E1 or the metabolism of the CYP2E1 substrate N,N-nitrosodimethylamine.	Propylthiouracil	18-21	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	338-344
7741770-7	1995	These data suggest that the ability of PTU to protect the liver from ethanol-induced injury may be due to a reduction in the levels of CYP-reductase, thereby minimizing the enhancement of microsomal oxygen consumption and free radical generation associated with ethanol-induced CYP2E1 activity.	Propylthiouracil	39-42	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	278-284
7887985-2	1995	6-Propylthiouracil (PTU), a widely used antithyroid drug for the treatment of Graves" disease, is also a potent inhibitor of Type I iodothyronine deiodinase (ID-1).	Propylthiouracil	0-18	iodothyronine deiodinase 1	Rattus norvegicus	125-156
7887985-2	1995	6-Propylthiouracil (PTU), a widely used antithyroid drug for the treatment of Graves" disease, is also a potent inhibitor of Type I iodothyronine deiodinase (ID-1).	Propylthiouracil	0-18	inhibitor of DNA binding 1, HLH protein	Rattus norvegicus	158-162
7887985-2	1995	6-Propylthiouracil (PTU), a widely used antithyroid drug for the treatment of Graves" disease, is also a potent inhibitor of Type I iodothyronine deiodinase (ID-1).	Propylthiouracil	20-23	iodothyronine deiodinase 1	Rattus norvegicus	125-156
7887985-2	1995	6-Propylthiouracil (PTU), a widely used antithyroid drug for the treatment of Graves" disease, is also a potent inhibitor of Type I iodothyronine deiodinase (ID-1).	Propylthiouracil	20-23	inhibitor of DNA binding 1, HLH protein	Rattus norvegicus	158-162
7887985-3	1995	Inhibition of ID-1 was attributed initially to the formation of a mixed disulfide between PTU and a putative cysteine residue at the active site.	Propylthiouracil	90-93	inhibitor of DNA binding 1, HLH protein	Rattus norvegicus	14-18
7887985-5	1995	It seemed possible, therefore, that the selenium analog of PTU (PSeU) might be a more potent inhibitor of ID-1 than PTU.	Propylthiouracil	59-62	inhibitor of DNA binding 1, HLH protein	Rattus norvegicus	106-110
7887985-16	1995	These results suggest that PTU and PSeU inhibit TPO-catalyzed iodination by similar mechanisms.	Propylthiouracil	27-30	thyroid peroxidase	Rattus norvegicus	48-51
7697876-4	1994	Hypothyroidism was induced by administration of propylthiouracil (PTU) from birth in the drinking water (1 g/l) for 10, 25 and 90 days; recovery was induced by withdrawal of PTU at P25.	Propylthiouracil	174-177	lipocalin 2	Rattus norvegicus	181-184
7965748-6	1994	PTU also reduced responsiveness of ornithine decarboxylase (ODC), a key enzyme that couples receptors to differentiation, again, changes in receptor-mediated responsiveness reflected alterations in total enzyme activity, rather than effects on receptor coupling.	Propylthiouracil	0-3	ornithine decarboxylase 1	Rattus norvegicus	35-58
7956920-8	1994	Compared to euthyroid thyrotrophs, the beta-1,4-galactosyltransferase mRNA level in thyrotrophs increased 440% after mice received PTU for 1 week; the mean increase within thyrotrophs over the 6-week period was 173%, whereas there was little change in corticotrophs.	Propylthiouracil	131-134	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1	Mus musculus	39-69
7524506-13	1994	As an inhibitor of ID-1, MSeI is much less than 1% as potent as PTU.	Propylthiouracil	64-67	inhibitor of DNA binding 1, HLH protein	Rattus norvegicus	19-23
7819453-6	1994	Additionally, thyroid hormone replacement in PTU-treated animals decreased MIS and c-erbA alpha mRNA expression to control levels.	Propylthiouracil	45-48	anti-Mullerian hormone	Rattus norvegicus	75-78
7819453-6	1994	Additionally, thyroid hormone replacement in PTU-treated animals decreased MIS and c-erbA alpha mRNA expression to control levels.	Propylthiouracil	45-48	thyroid hormone receptor alpha	Rattus norvegicus	83-95
7965748-6	1994	PTU also reduced responsiveness of ornithine decarboxylase (ODC), a key enzyme that couples receptors to differentiation, again, changes in receptor-mediated responsiveness reflected alterations in total enzyme activity, rather than effects on receptor coupling.	Propylthiouracil	0-3	ornithine decarboxylase 1	Rattus norvegicus	60-63
7965748-7	1994	In contrast, measurements of c-fos, a protooncogene that couples cyclic AMP to induction of ODC, showed increased responses to beta adrenergic or cyclic AMP stimulation in PTU-treated animals.	Propylthiouracil	172-175	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	29-34
7965748-7	1994	In contrast, measurements of c-fos, a protooncogene that couples cyclic AMP to induction of ODC, showed increased responses to beta adrenergic or cyclic AMP stimulation in PTU-treated animals.	Propylthiouracil	172-175	ornithine decarboxylase 1	Rattus norvegicus	92-95
7965748-8	1994	The effect of PTU on c-fos responsiveness occurred in the absence of alterations in basal c-fos expression, a situation different from that seen with adenylate cyclase or ODC.	Propylthiouracil	14-17	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	21-26
7530522-2	1994	Because of a recent report of use of recombinant human granulocyte colony-stimulating factor (G-CSF) in patients with propylthiouracil-induced agranulocytosis, 5 micrograms/kg/day G-CSF was administered and her granulocyte count returned to normal after three doses, on the sixth day after the last dose of methimazole.	Propylthiouracil	118-134	colony stimulating factor 3	Homo sapiens	55-92
7530522-2	1994	Because of a recent report of use of recombinant human granulocyte colony-stimulating factor (G-CSF) in patients with propylthiouracil-induced agranulocytosis, 5 micrograms/kg/day G-CSF was administered and her granulocyte count returned to normal after three doses, on the sixth day after the last dose of methimazole.	Propylthiouracil	118-134	colony stimulating factor 3	Homo sapiens	94-99
8052658-5	1994	We report here that the protein encoded by the XL-15 cDNA efficiently catalyzes the (inner ring) 5-deiodination of 3,5,3"-triiodothyronine with a Km value of 2 nM and is resistant to inhibition by propylthiouracil and aurothioglucose.	Propylthiouracil	197-213	deiodinase, iodothyronine, type 3 L homeolog	Xenopus laevis	47-52
8160659-4	1994	During treatment with propylthiouracil, serial observations demonstrated a decline in serum osteocalcin that paralleled a decline in blood lead levels.	Propylthiouracil	22-38	bone gamma-carboxyglutamate protein	Homo sapiens	92-103
8068032-8	1994	The combination of PTU, with cisplatin increased total GST, GST-alpha and GSHpx activity, compared to the cisplatin alone group.	Propylthiouracil	19-22	glutathione peroxidase 1	Rattus norvegicus	74-79
8051490-5	1994	Soluble CD8 > or = 450 U/ml is sensitive, specific, and predictive of PTU success as sole therapy or need for definitive therapy in untreated and PTU-treated Graves" hyperthyroidism, exceeding the predictive values of thyroid-stimulating hormone receptor antibody, thyroid peroxidase antibody, and T3 radioimmunoassay.	Propylthiouracil	73-76	CD8a molecule	Homo sapiens	8-11
8051490-5	1994	Soluble CD8 > or = 450 U/ml is sensitive, specific, and predictive of PTU success as sole therapy or need for definitive therapy in untreated and PTU-treated Graves" hyperthyroidism, exceeding the predictive values of thyroid-stimulating hormone receptor antibody, thyroid peroxidase antibody, and T3 radioimmunoassay.	Propylthiouracil	149-152	CD8a molecule	Homo sapiens	8-11
8152263-7	1994	Acetaminophen, N-acetylcysteine, propylthiouracil, D-penicillamine, mefenamic acid, dapsone, and methimazole all inhibited MPO at clinically achievable concentrations.	Propylthiouracil	33-49	myeloperoxidase	Homo sapiens	123-126
8068032-2	1994	t-Stilbene oxide (t-SO) and propylthiouracil (PTU) were the GST inducers, and ketoprofen was the GST inhibitor.	Propylthiouracil	46-49	hematopoietic prostaglandin D synthase	Rattus norvegicus	60-63
8068032-8	1994	The combination of PTU, with cisplatin increased total GST, GST-alpha and GSHpx activity, compared to the cisplatin alone group.	Propylthiouracil	19-22	hematopoietic prostaglandin D synthase	Rattus norvegicus	55-58
8068032-8	1994	The combination of PTU, with cisplatin increased total GST, GST-alpha and GSHpx activity, compared to the cisplatin alone group.	Propylthiouracil	19-22	hematopoietic prostaglandin D synthase	Rattus norvegicus	60-63
8293854-8	1993	bolus injection of vasoactive intestinal peptide (VIP, 150 mu g/kg) was markedly reduced in hypothyroid rats after one week of PTU ingestion and reached the lowest value after two weeks.	Propylthiouracil	127-130	vasoactive intestinal peptide	Rattus norvegicus	50-53
8119200-2	1994	Propylthiouracil (PTU)-induced hypothyroidism caused a significant reduction in CRH gene transcripts in the paraventricular nucleus of male rats, with a concomitant decrease in both POMC gene expression in the anterior pituitary gland and circulating corticosterone.	Propylthiouracil	0-16	corticotropin releasing hormone	Rattus norvegicus	80-83
8119200-2	1994	Propylthiouracil (PTU)-induced hypothyroidism caused a significant reduction in CRH gene transcripts in the paraventricular nucleus of male rats, with a concomitant decrease in both POMC gene expression in the anterior pituitary gland and circulating corticosterone.	Propylthiouracil	0-16	proopiomelanocortin	Rattus norvegicus	182-186
8119200-2	1994	Propylthiouracil (PTU)-induced hypothyroidism caused a significant reduction in CRH gene transcripts in the paraventricular nucleus of male rats, with a concomitant decrease in both POMC gene expression in the anterior pituitary gland and circulating corticosterone.	Propylthiouracil	18-21	corticotropin releasing hormone	Rattus norvegicus	80-83
8119200-2	1994	Propylthiouracil (PTU)-induced hypothyroidism caused a significant reduction in CRH gene transcripts in the paraventricular nucleus of male rats, with a concomitant decrease in both POMC gene expression in the anterior pituitary gland and circulating corticosterone.	Propylthiouracil	18-21	proopiomelanocortin	Rattus norvegicus	182-186
8293854-9	1993	The PRL response to VIP was progressively recovered after treatment for 4 weeks with PTU, and reached the highest value in 24-week hypothyroid rats.	Propylthiouracil	85-88	vasoactive intestinal peptide	Rattus norvegicus	20-23
8250859-7	1993	Propylthiouracil also inactivates GPO activity in the same manner but its efficiency (k(inact./ki = 0.46 mM-1 x min-1) is about 10 times lower than that of MMI (k(inact./ki = 5 mM-1 x min-1).	Propylthiouracil	0-16	CD59 molecule (CD59 blood group)	Homo sapiens	184-189
8250859-7	1993	Propylthiouracil also inactivates GPO activity in the same manner but its efficiency (k(inact./ki = 0.46 mM-1 x min-1) is about 10 times lower than that of MMI (k(inact./ki = 5 mM-1 x min-1).	Propylthiouracil	0-16	CD59 molecule (CD59 blood group)	Homo sapiens	112-117
8227947-1	1993	Propylthiouracil is an antithyroid drug which is carried by the blood, thanks to its binding with human seroalbumin (HSA), and induces a structural alteration in HSA that changes the binding capability of other ligands.	Propylthiouracil	0-16	albumin	Homo sapiens	117-120
8227947-1	1993	Propylthiouracil is an antithyroid drug which is carried by the blood, thanks to its binding with human seroalbumin (HSA), and induces a structural alteration in HSA that changes the binding capability of other ligands.	Propylthiouracil	0-16	albumin	Homo sapiens	162-165
8227947-2	1993	Then, with the aim of fixing the functional group in propylthiouracil involved in the interactions with HSA, the binding parameters for several uracil derivatives bound on HSA have been estimated.	Propylthiouracil	53-69	albumin	Homo sapiens	104-107
8227947-2	1993	Then, with the aim of fixing the functional group in propylthiouracil involved in the interactions with HSA, the binding parameters for several uracil derivatives bound on HSA have been estimated.	Propylthiouracil	53-69	albumin	Homo sapiens	172-175
8227947-3	1993	Interaction of propyluracil, thiouracil and propylthiouracil with HSA leads to the formation of complexes that show spectral shifts.	Propylthiouracil	44-60	albumin	Homo sapiens	66-69
7693564-1	1993	In propylthiouracil (PTU)-fed (g/kg feed) hypothyroid cockerels, serum levels of growth hormone (GH), but not insulin-like growth factor (IGF)-1, tended to rise and those of IGF-binding activity to fall.	Propylthiouracil	3-19	growth hormone 1	Homo sapiens	81-95
7693564-1	1993	In propylthiouracil (PTU)-fed (g/kg feed) hypothyroid cockerels, serum levels of growth hormone (GH), but not insulin-like growth factor (IGF)-1, tended to rise and those of IGF-binding activity to fall.	Propylthiouracil	21-24	growth hormone 1	Homo sapiens	97-99
7693564-1	1993	In propylthiouracil (PTU)-fed (g/kg feed) hypothyroid cockerels, serum levels of growth hormone (GH), but not insulin-like growth factor (IGF)-1, tended to rise and those of IGF-binding activity to fall.	Propylthiouracil	3-19	growth hormone 1	Homo sapiens	97-99
7693564-1	1993	In propylthiouracil (PTU)-fed (g/kg feed) hypothyroid cockerels, serum levels of growth hormone (GH), but not insulin-like growth factor (IGF)-1, tended to rise and those of IGF-binding activity to fall.	Propylthiouracil	21-24	growth hormone 1	Homo sapiens	81-95
8275799-6	1993	PTU-induced hypothyroidism resulted in decreased concentrations of plasma ANP.	Propylthiouracil	0-3	natriuretic peptide A	Rattus norvegicus	74-77
8340196-0	1993	Effect of propylthiouracil and methimazole on serum levels of interleukin-2 receptors in patients with psoriasis.	Propylthiouracil	10-26	interleukin 2	Homo sapiens	62-75
8340196-7	1993	After treatment with PTU or MMI, IL2R serum concentrations were not significantly reduced either in the group as a whole or separately in the PTU and MMI treated patients.	Propylthiouracil	21-24	interleukin 2 receptor subunit alpha	Homo sapiens	33-37
8260547-7	1993	Pups of propylthiouracil (PTU)-treated dams (previously found to be hypothyroid) showed a delay in the maturation of lingual lipase compared to age-matched pups whose dam was not given PTU.	Propylthiouracil	8-24	lipase F, gastric type	Rattus norvegicus	117-131
8260547-7	1993	Pups of propylthiouracil (PTU)-treated dams (previously found to be hypothyroid) showed a delay in the maturation of lingual lipase compared to age-matched pups whose dam was not given PTU.	Propylthiouracil	26-29	lipase F, gastric type	Rattus norvegicus	117-131
8260547-9	1993	PTU-induced delayed maturation of lingual lipase was a result of hypothyroidism, since T4 replacement when given early (at the age of 5 days) abolished most of the effect of PTU.	Propylthiouracil	0-3	lipase F, gastric type	Rattus norvegicus	34-48
8457909-2	1993	In this work, the 5"-DII activity has been studied in different situations of experimental hypothyroidism (propylthiouracil, methimazole, thyroidectomy, and low iodine diet), in various brain regions (pituitary, cerebellum, brain stem, hypothalamus, cortex, and whole brain) in adult rats.	Propylthiouracil	107-123	iodothyronine deiodinase 2	Rattus norvegicus	18-24
8275799-7	1993	Replacement of T4 in PTU-treated hypothyroid rats restored the plasma concentrations of ANP to normal levels.	Propylthiouracil	21-24	natriuretic peptide A	Rattus norvegicus	88-91
8275799-8	1993	Furthermore, we examined the right atrial ANP contents and the in vitro release of ANP in PTU-treated rats and control animals.	Propylthiouracil	90-93	natriuretic peptide A	Rattus norvegicus	83-86
8275799-12	1993	The in vitro release of ANP in response to 165 mM sodium ion was significantly lower in PTU than in saline-injected animals.	Propylthiouracil	88-91	natriuretic peptide A	Rattus norvegicus	24-27
1740487-7	1992	Labeling of p27 was strongly inhibited by preferred type I 5"-D substrate rT3, but to a lesser extent by poor substrate T4 or T3, and the type I 5"-D inhibitor, propylthiouracil and iopanoic acid, also inhibited the p27 labeling in normal and various diseases.	Propylthiouracil	161-177	interferon alpha inducible protein 27	Homo sapiens	12-15
7509672-0	1993	Propylthiouracil (PTU)-induced agranulocytosis treated with recombinant human granulocyte colony-stimulating factor (G-CSF).	Propylthiouracil	0-16	colony stimulating factor 3	Homo sapiens	78-115
7509672-0	1993	Propylthiouracil (PTU)-induced agranulocytosis treated with recombinant human granulocyte colony-stimulating factor (G-CSF).	Propylthiouracil	0-16	colony stimulating factor 3	Homo sapiens	117-122
7509672-0	1993	Propylthiouracil (PTU)-induced agranulocytosis treated with recombinant human granulocyte colony-stimulating factor (G-CSF).	Propylthiouracil	18-21	colony stimulating factor 3	Homo sapiens	78-115
7509672-0	1993	Propylthiouracil (PTU)-induced agranulocytosis treated with recombinant human granulocyte colony-stimulating factor (G-CSF).	Propylthiouracil	18-21	colony stimulating factor 3	Homo sapiens	117-122
7509672-8	1993	The first patient received 300 micrograms of G-CSF on days 2 and 4 after discontinuing PTU with the appearance of 4.7 x 10(9)/L granulocytes and granulocyte precursors on day 4.	Propylthiouracil	87-90	colony stimulating factor 3	Homo sapiens	45-50
1352477-4	1992	Treatment with propylthiouracil for 10 days decreased somatostatin mRNA, markedly increased growth hormone-releasing factor mRNA but had no significant effect on insulin-like growth factor 2 mRNA.	Propylthiouracil	15-31	somatostatin	Rattus norvegicus	54-66
1352477-4	1992	Treatment with propylthiouracil for 10 days decreased somatostatin mRNA, markedly increased growth hormone-releasing factor mRNA but had no significant effect on insulin-like growth factor 2 mRNA.	Propylthiouracil	15-31	growth hormone releasing hormone	Rattus norvegicus	92-123
1532179-8	1992	These results demonstrate that, in Graves" retroocular fibroblasts, H2O2-induced HSP 72 expression is diminished both by classical ORS and by the antithyroid agents PTU and MT.	Propylthiouracil	165-168	heat shock protein family A (Hsp70) member 1A	Homo sapiens	81-87
1740487-7	1992	Labeling of p27 was strongly inhibited by preferred type I 5"-D substrate rT3, but to a lesser extent by poor substrate T4 or T3, and the type I 5"-D inhibitor, propylthiouracil and iopanoic acid, also inhibited the p27 labeling in normal and various diseases.	Propylthiouracil	161-177	interferon alpha inducible protein 27	Homo sapiens	216-219
1471994-2	1992	Propylthiouracil decreased both hepatic LRP and LDL receptor expression by 30-40%.	Propylthiouracil	0-16	protein tyrosine phosphatase, receptor type, A	Rattus norvegicus	40-43
1471994-2	1992	Propylthiouracil decreased both hepatic LRP and LDL receptor expression by 30-40%.	Propylthiouracil	0-16	low density lipoprotein receptor	Rattus norvegicus	48-60
1318692-11	1992	The thioureylene drugs, propylthiouracil and methimazole, inhibited MPO-catalyzed iodination both reversibly and irreversibly, in a manner similar to that previously described for TPO-catalyzed iodination.	Propylthiouracil	24-40	myeloperoxidase	Homo sapiens	68-71
1318692-11	1992	The thioureylene drugs, propylthiouracil and methimazole, inhibited MPO-catalyzed iodination both reversibly and irreversibly, in a manner similar to that previously described for TPO-catalyzed iodination.	Propylthiouracil	24-40	thyroid peroxidase	Homo sapiens	180-183
1564567-6	1992	The activities of carbamylphosphate, synthetase, ornithine aminotransferase and ornithine decarboxylase in liver of the group treated with 6-propyl-2-thiouracil alone were significantly lower than those of the 6-propyl-2-thiouracil plus triiodothyronine-treated group.	Propylthiouracil	139-160	ornithine aminotransferase	Rattus norvegicus	37-75
1564567-6	1992	The activities of carbamylphosphate, synthetase, ornithine aminotransferase and ornithine decarboxylase in liver of the group treated with 6-propyl-2-thiouracil alone were significantly lower than those of the 6-propyl-2-thiouracil plus triiodothyronine-treated group.	Propylthiouracil	139-160	ornithine decarboxylase 1	Rattus norvegicus	80-103
1316544-9	1992	Both PC1 and PC2 mRNA levels were increased 5- to 9-fold in animals made hypothyroid by treatment with 6-n-propyl-2-thiouracil.	Propylthiouracil	103-126	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	5-8
1316544-9	1992	Both PC1 and PC2 mRNA levels were increased 5- to 9-fold in animals made hypothyroid by treatment with 6-n-propyl-2-thiouracil.	Propylthiouracil	103-126	proprotein convertase subtilisin/kexin type 2	Rattus norvegicus	13-16
1608507-3	1992	Hippocampal mossy fiber zinc density was reduced by 75% in both the dorsal and ventral hippocampal formation CA3 stratum lucidum region of 31-day-old PTU-treated rats compared to untreated controls.	Propylthiouracil	150-153	carbonic anhydrase 3	Rattus norvegicus	109-112
1543535-6	1992	In the male rat, PTU treatment markedly increased (three- to fourfold) PRL-R mRNA in the liver but decreased it (approximately 50%) in the kidney.	Propylthiouracil	17-20	prolactin receptor	Rattus norvegicus	71-76
1543535-11	1992	There was an unexpected threefold rise in PRL-R mRNA in the female kidney following combined T4 and PTU treatment.	Propylthiouracil	100-103	prolactin receptor	Rattus norvegicus	42-47
1311579-6	1992	PTU was less reactive towards superoxide generated by the xanthine/xanthine oxidase system, having a small but significant inhibitory effect on superoxide-induced reduction of cytochrome c only at a concentration of 200 microM.	Propylthiouracil	0-3	cytochrome c, somatic	Homo sapiens	176-188
1560306-9	1992	These results demonstrate that estrogen and PTU act on the growth of ER-positive rat thyroid tumors.	Propylthiouracil	44-47	estrogen receptor 1	Rattus norvegicus	69-71
1420805-7	1992	In hyperthyroid GD patients, PTU therapy induced rapid and specific changes within the Ia+ CD3+ subsets, namely a reduction in the Ia+ CD4+ subset and an increase in the Ia+ CD8+ subset, resulting in a marked decrease in the Ia+ CD4+/Ia+ CD8+ ratio.	Propylthiouracil	29-32	CD4 molecule	Homo sapiens	135-138
1420805-7	1992	In hyperthyroid GD patients, PTU therapy induced rapid and specific changes within the Ia+ CD3+ subsets, namely a reduction in the Ia+ CD4+ subset and an increase in the Ia+ CD8+ subset, resulting in a marked decrease in the Ia+ CD4+/Ia+ CD8+ ratio.	Propylthiouracil	29-32	CD8a molecule	Homo sapiens	174-177
1420805-7	1992	In hyperthyroid GD patients, PTU therapy induced rapid and specific changes within the Ia+ CD3+ subsets, namely a reduction in the Ia+ CD4+ subset and an increase in the Ia+ CD8+ subset, resulting in a marked decrease in the Ia+ CD4+/Ia+ CD8+ ratio.	Propylthiouracil	29-32	CD4 molecule	Homo sapiens	229-232
1420805-7	1992	In hyperthyroid GD patients, PTU therapy induced rapid and specific changes within the Ia+ CD3+ subsets, namely a reduction in the Ia+ CD4+ subset and an increase in the Ia+ CD8+ subset, resulting in a marked decrease in the Ia+ CD4+/Ia+ CD8+ ratio.	Propylthiouracil	29-32	CD8a molecule	Homo sapiens	238-241
1794603-0	1991	Methimazole and propylthiouracil increase thyroglobulin gene expression in FRTL-5 cells.	Propylthiouracil	16-32	thyroglobulin	Rattus norvegicus	42-55
1794603-1	1991	In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium.	Propylthiouracil	39-55	thyroid peroxidase	Rattus norvegicus	68-86
1794603-1	1991	In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium.	Propylthiouracil	39-55	thyroid peroxidase	Rattus norvegicus	88-91
1794603-1	1991	In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium.	Propylthiouracil	39-55	thyroglobulin	Rattus norvegicus	114-127
1794603-1	1991	In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium.	Propylthiouracil	39-55	thyroglobulin	Rattus norvegicus	129-131
1794603-1	1991	In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium.	Propylthiouracil	39-55	thyroglobulin	Rattus norvegicus	149-151
1794603-1	1991	In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium.	Propylthiouracil	57-60	thyroid peroxidase	Rattus norvegicus	68-86
1794603-1	1991	In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium.	Propylthiouracil	57-60	thyroid peroxidase	Rattus norvegicus	88-91
1794603-1	1991	In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium.	Propylthiouracil	57-60	thyroglobulin	Rattus norvegicus	114-127
1794603-1	1991	In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium.	Propylthiouracil	57-60	thyroglobulin	Rattus norvegicus	129-131
1794603-1	1991	In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium.	Propylthiouracil	57-60	thyroglobulin	Rattus norvegicus	149-151
1794603-2	1991	An increase in Tg mRNA levels and in Tg accumulation was observed after 2-4 h and 8 h incubation with 10,000 microM MMI or PTU, respectively.	Propylthiouracil	123-126	thyroglobulin	Rattus norvegicus	15-17
1794603-2	1991	An increase in Tg mRNA levels and in Tg accumulation was observed after 2-4 h and 8 h incubation with 10,000 microM MMI or PTU, respectively.	Propylthiouracil	123-126	thyroglobulin	Rattus norvegicus	37-39
1996631-2	1991	Treating rats with propylthiouracil (PTU) for 4-5 mo resulted in a 55% decrease (P less than 0.001) in citrate synthase activity in plantaris muscle and phenotypic remodeling of the plantaris, evident by a threefold increase in type I fiber area and a 13% decrease in type II fiber area.	Propylthiouracil	37-40	citrate synthase	Rattus norvegicus	103-119
1850263-3	1991	Propylthiouracil, an inhibitor of myeloperoxidase, and Ca2+ chelators prevented activation of myeloperoxidase and phagocytosis by A23187.	Propylthiouracil	0-16	myeloperoxidase	Rattus norvegicus	34-49
1850263-3	1991	Propylthiouracil, an inhibitor of myeloperoxidase, and Ca2+ chelators prevented activation of myeloperoxidase and phagocytosis by A23187.	Propylthiouracil	0-16	myeloperoxidase	Rattus norvegicus	94-109
2001246-5	1991	ID-I was much more sensitive than PDI to the inhibitory effects of PTU both in vitro and in vivo.	Propylthiouracil	67-70	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	34-37
1996631-2	1991	Treating rats with propylthiouracil (PTU) for 4-5 mo resulted in a 55% decrease (P less than 0.001) in citrate synthase activity in plantaris muscle and phenotypic remodeling of the plantaris, evident by a threefold increase in type I fiber area and a 13% decrease in type II fiber area.	Propylthiouracil	19-35	citrate synthase	Rattus norvegicus	103-119
1935806-3	1991	This study used dual labeling to determine which pituitary cells expressed TR beta-2 mRNA in normal and PTU-treated rats.	Propylthiouracil	104-107	thyroid hormone receptor beta	Rattus norvegicus	75-82
1935806-5	1991	In dispersed pituitary cells, 20 +/- 2% (average +/- SD) of cells from normal rats and 30 +/- 3% of cells from PTU-treated rats were labeled for TR beta-2 mRNA.	Propylthiouracil	111-114	thyroid hormone receptor beta	Rattus norvegicus	145-152
1935806-13	1991	PTU treatment increased the percentage of TSH cells with TR beta-2 mRNA to 72 +/- 4% and decreased the percentage of GH cells with TR beta-2 mRNA to 30 +/- 3%.	Propylthiouracil	0-3	thyroid hormone receptor beta	Rattus norvegicus	57-64
1935806-13	1991	PTU treatment increased the percentage of TSH cells with TR beta-2 mRNA to 72 +/- 4% and decreased the percentage of GH cells with TR beta-2 mRNA to 30 +/- 3%.	Propylthiouracil	0-3	thyroid hormone receptor beta	Rattus norvegicus	131-138
1802681-2	1991	In T3 loaded rats, the grafted tumor showed high estrogen receptor levels (160-200% of control), whereas low estrogen receptor levels (20-35% of control) were observed in the tumors grown in Tx and PTU treated rats.	Propylthiouracil	198-201	estrogen receptor 1	Rattus norvegicus	109-126
1901393-5	1991	Hypothyroidism induced by propylthiouracil treatment is accompanied by a decrease of beta-endorphin in the neuro-intermediate lobe and a decrease in met-enkephalin in the anterior lobe while thyroidectomy entails a decrease in met-enkephalin in the anterior lobe only.	Propylthiouracil	26-42	proopiomelanocortin	Homo sapiens	85-99
1847210-3	1991	Hypothyroidism induced by propylthiouracil administration led to persistent subsensitivity of the cardiac ODC response to beta receptor stimulation.	Propylthiouracil	26-42	ornithine decarboxylase 1	Rattus norvegicus	106-109
1994176-8	1991	Propylthiouracil administration (hypothyroidism) lowered the MDI activity, but elevated the PDI activity.	Propylthiouracil	0-16	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	92-95
1901393-5	1991	Hypothyroidism induced by propylthiouracil treatment is accompanied by a decrease of beta-endorphin in the neuro-intermediate lobe and a decrease in met-enkephalin in the anterior lobe while thyroidectomy entails a decrease in met-enkephalin in the anterior lobe only.	Propylthiouracil	26-42	proopiomelanocortin	Homo sapiens	149-163
1901393-5	1991	Hypothyroidism induced by propylthiouracil treatment is accompanied by a decrease of beta-endorphin in the neuro-intermediate lobe and a decrease in met-enkephalin in the anterior lobe while thyroidectomy entails a decrease in met-enkephalin in the anterior lobe only.	Propylthiouracil	26-42	proopiomelanocortin	Homo sapiens	227-241
2387252-9	1990	Liver and intestinal apo-A-I mRNA levels and plasma apo-A-I concentrations remain constant after propylthiouracil treatment.	Propylthiouracil	97-113	apolipoprotein A1	Rattus norvegicus	21-28
1704483-3	1990	Levels of PAM mRNA increased 4- to 7-fold in animals made hypothyroid by treatment with 6-n-propyl-2-thiouracil or thyroidectomy and were not diminished below control levels in animals made hyperthyroid by treatment with T4.	Propylthiouracil	88-111	peptidylglycine alpha-amidating monooxygenase	Rattus norvegicus	10-13
2159305-0	1990	Mechanism of inactivation of myeloperoxidase by propylthiouracil.	Propylthiouracil	48-64	myeloperoxidase	Rattus norvegicus	29-44
2112814-8	1990	Propylthiouracil also increased interleukin 2 levels (p less than 0.001) and significantly decreased beta 2 microglobulin production (p less than 0.01).	Propylthiouracil	0-16	interleukin 2	Homo sapiens	32-45
2112814-8	1990	Propylthiouracil also increased interleukin 2 levels (p less than 0.001) and significantly decreased beta 2 microglobulin production (p less than 0.01).	Propylthiouracil	0-16	beta-2-microglobulin	Homo sapiens	101-121
2339984-2	1990	On Northern-blot analysis with gene-specific oligonucleotide probes, the steady-state mRNA levels of S1, S2, S3, K1 and P1 were all dramatically altered in the SMG of male and female rats treated with propylthiouracil (PTU; 100 mg/litre of drinking water) or thyroxine (T4; 10 micrograms/100 mg body wt.)	Propylthiouracil	201-217	keratin 1	Rattus norvegicus	113-122
2339984-2	1990	On Northern-blot analysis with gene-specific oligonucleotide probes, the steady-state mRNA levels of S1, S2, S3, K1 and P1 were all dramatically altered in the SMG of male and female rats treated with propylthiouracil (PTU; 100 mg/litre of drinking water) or thyroxine (T4; 10 micrograms/100 mg body wt.)	Propylthiouracil	219-222	keratin 1	Rattus norvegicus	113-122
2159305-1	1990	The mechanism of inactivation of myeloperoxidase purified from rat bone marrow by propylthiouracil (PTU) was studied.	Propylthiouracil	82-98	myeloperoxidase	Rattus norvegicus	33-48
2159305-1	1990	The mechanism of inactivation of myeloperoxidase purified from rat bone marrow by propylthiouracil (PTU) was studied.	Propylthiouracil	100-103	myeloperoxidase	Rattus norvegicus	33-48
2159305-2	1990	PTU inhibited not only the peroxidase activity but also the chlorinating activity of myeloperoxidase in a concentration dependent manner.	Propylthiouracil	0-3	myeloperoxidase	Rattus norvegicus	85-100
2159305-3	1990	When myeloperoxidase was treated with PTU and hydrogen peroxide (5 microM), inactivation of the enzyme was still observed after the excess reagents were removed by a column of Sephadex G-25.	Propylthiouracil	38-41	myeloperoxidase	Rattus norvegicus	5-20
2159305-5	1990	In addition, [14C]PTU became bound to myeloperoxidase in the presence of hydrogen peroxide.	Propylthiouracil	18-21	myeloperoxidase	Rattus norvegicus	38-53
2159305-7	1990	Difference spectrum of myeloperoxidase treated with PTU in the presence of a low concentration of hydrogen peroxide (5 microM) was similar to that of compound II.	Propylthiouracil	52-55	myeloperoxidase	Rattus norvegicus	23-38
2159305-8	1990	Therefore, these results indicate that PTU inactivates myeloperoxidase through binding to the enzyme and the conversion to a compound II-like form in the presence of hydrogen peroxide.	Propylthiouracil	39-42	myeloperoxidase	Rattus norvegicus	55-70
10984312-2	1998	Serum concentrations of GH were not affected by propylthiouracil (PTU) or thyroxine (T4) treatments, whereas serum IGF-I levels were significantly decreased in PTU-treated chickens.	Propylthiouracil	160-163	insulin like growth factor 1	Gallus gallus	115-120
2326285-1	1990	Experiments were performed both in vivo and in vitro to test a previous proposal that part of the antithyroid action of the thioureylene drugs, propylthiouracil (PTU) and methylmercaptoimidazole, can be attributed to inhibition of thyroglobulin (Tg) biosynthesis.	Propylthiouracil	162-165	thyroglobulin	Rattus norvegicus	231-244
2314053-1	1990	The effects of hypothyroidism induced by propylthiouracil (PTU) treatment on growth hormone (GH) and prolactin (PRL) messenger ribonucleic acid (mRNA) levels were analyzed in adult female rat adenohypophyses by in situ hybridization histochemistry and Northern hybridization analyses.	Propylthiouracil	41-57	gonadotropin releasing hormone receptor	Rattus norvegicus	77-91
2314053-1	1990	The effects of hypothyroidism induced by propylthiouracil (PTU) treatment on growth hormone (GH) and prolactin (PRL) messenger ribonucleic acid (mRNA) levels were analyzed in adult female rat adenohypophyses by in situ hybridization histochemistry and Northern hybridization analyses.	Propylthiouracil	41-57	gonadotropin releasing hormone receptor	Rattus norvegicus	93-95
2314053-1	1990	The effects of hypothyroidism induced by propylthiouracil (PTU) treatment on growth hormone (GH) and prolactin (PRL) messenger ribonucleic acid (mRNA) levels were analyzed in adult female rat adenohypophyses by in situ hybridization histochemistry and Northern hybridization analyses.	Propylthiouracil	41-57	prolactin	Rattus norvegicus	101-110
2314053-1	1990	The effects of hypothyroidism induced by propylthiouracil (PTU) treatment on growth hormone (GH) and prolactin (PRL) messenger ribonucleic acid (mRNA) levels were analyzed in adult female rat adenohypophyses by in situ hybridization histochemistry and Northern hybridization analyses.	Propylthiouracil	59-62	gonadotropin releasing hormone receptor	Rattus norvegicus	77-91
2314053-1	1990	The effects of hypothyroidism induced by propylthiouracil (PTU) treatment on growth hormone (GH) and prolactin (PRL) messenger ribonucleic acid (mRNA) levels were analyzed in adult female rat adenohypophyses by in situ hybridization histochemistry and Northern hybridization analyses.	Propylthiouracil	59-62	gonadotropin releasing hormone receptor	Rattus norvegicus	93-95
2314053-1	1990	The effects of hypothyroidism induced by propylthiouracil (PTU) treatment on growth hormone (GH) and prolactin (PRL) messenger ribonucleic acid (mRNA) levels were analyzed in adult female rat adenohypophyses by in situ hybridization histochemistry and Northern hybridization analyses.	Propylthiouracil	59-62	prolactin	Rattus norvegicus	101-110
2314053-2	1990	Twenty-eight days of PTU treatment produced a significant decrease in GH mRNA levels and a smaller decrease in PRL mRNA determined by both in situ hybridization histochemistry and Northern hybridization analyses.	Propylthiouracil	21-24	gonadotropin releasing hormone receptor	Rattus norvegicus	70-72
2314053-2	1990	Twenty-eight days of PTU treatment produced a significant decrease in GH mRNA levels and a smaller decrease in PRL mRNA determined by both in situ hybridization histochemistry and Northern hybridization analyses.	Propylthiouracil	21-24	prolactin	Rattus norvegicus	111-114
2298927-4	1990	The expression of NF-H immunoreactivity is almost completely suppressed in rats rendered hypothyroid by neonatal treatment with propylthiouracil.	Propylthiouracil	128-144	neurofilament heavy chain	Rattus norvegicus	18-22
20025630-8	2010	Up-regulation of caveolin-1 and down-regulation of synaptophysin were observed in the iodine-deficient and PTU-treated rats.	Propylthiouracil	107-110	caveolin 1	Rattus norvegicus	17-27
20025630-8	2010	Up-regulation of caveolin-1 and down-regulation of synaptophysin were observed in the iodine-deficient and PTU-treated rats.	Propylthiouracil	107-110	synaptophysin	Rattus norvegicus	51-64
1691456-5	1990	Similarly, GAL concentrations were decreased 39% in the ME and 69% in the AP of animals rendered hypothyroid by treatment with propylthiouracil (PTU).	Propylthiouracil	127-143	galanin and GMAP prepropeptide	Rattus norvegicus	11-14
1691456-5	1990	Similarly, GAL concentrations were decreased 39% in the ME and 69% in the AP of animals rendered hypothyroid by treatment with propylthiouracil (PTU).	Propylthiouracil	145-148	galanin and GMAP prepropeptide	Rattus norvegicus	11-14
2136727-7	1990	Although T4-increased rANP mRNA levels were also inhibited by propylthiouracil, methimazole did not alter the effect of T4.	Propylthiouracil	62-78	natriuretic peptide A	Rattus norvegicus	22-26
10984312-3	1998	The lowered serum IGF-I levels in the PTU-treated group were completely restored to the control levels by T4 injections.	Propylthiouracil	38-41	insulin like growth factor 1	Gallus gallus	18-23
10984312-4	1998	In the liver, the messenger RNA (mRNA) expressions both for GH receptor (GHR) and IGF-I were significantly repressed by PTU treatment, and were restored again by T4 replacement.	Propylthiouracil	120-123	growth hormone receptor	Gallus gallus	60-71
10984312-4	1998	In the liver, the messenger RNA (mRNA) expressions both for GH receptor (GHR) and IGF-I were significantly repressed by PTU treatment, and were restored again by T4 replacement.	Propylthiouracil	120-123	growth hormone receptor	Gallus gallus	73-76
10984312-4	1998	In the liver, the messenger RNA (mRNA) expressions both for GH receptor (GHR) and IGF-I were significantly repressed by PTU treatment, and were restored again by T4 replacement.	Propylthiouracil	120-123	insulin like growth factor 1	Gallus gallus	82-87
34757178-3	2022	For the potent TPO-inhibiting drug propylthiouracil (PTU) this has been shown to result in thyroid hormone system disruption and altered brain development in animal studies.	Propylthiouracil	35-51	thyroid peroxidase	Rattus norvegicus	15-18
34935172-11	2022	Kv1.1 protein level decreased significantly in the sciatic nerve of the PTU-administered group.	Propylthiouracil	72-75	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	0-5
34757178-3	2022	For the potent TPO-inhibiting drug propylthiouracil (PTU) this has been shown to result in thyroid hormone system disruption and altered brain development in animal studies.	Propylthiouracil	53-56	thyroid peroxidase	Rattus norvegicus	15-18
34684053-4	2021	After switching to propylthiouracil, the serum CK level decreased to normal, and the myalgia was resolved.	Propylthiouracil	19-35	cytidine/uridine monophosphate kinase 1	Homo sapiens	47-49
34984343-9	2022	mRNA contents of deiodinase 2 and thyroid hormone receptor alpha were similar in mesenteric arteries of two groups but were elevated in sural arteries of PTU group compared to CON.	Propylthiouracil	154-157	thyroid hormone receptor alpha	Rattus norvegicus	34-64
34984343-10	2022	The abundance of eNOS protein was higher in sural arteries of PTU compared to CON rats.	Propylthiouracil	62-65	nitric oxide synthase 3	Rattus norvegicus	17-21
34175303-11	2021	Analysis of STORM data of PTU myocytes showed decreased RyR2 cluster numbers and RyR localizations within each cluster without significant changes in Cav1.2 localizations within RyR clusters.	Propylthiouracil	26-29	ryanodine receptor 2	Rattus norvegicus	56-60
34175303-11	2021	Analysis of STORM data of PTU myocytes showed decreased RyR2 cluster numbers and RyR localizations within each cluster without significant changes in Cav1.2 localizations within RyR clusters.	Propylthiouracil	26-29	ryanodine receptor 2	Rattus norvegicus	81-84
34832976-8	2021	Subsequently, the in vitro metabolism of PTU was assessed and UGT1A9 was identified as an important UGT isoform responsible for the glucuronidation of PTU.	Propylthiouracil	41-44	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	100-103
34832976-8	2021	Subsequently, the in vitro metabolism of PTU was assessed and UGT1A9 was identified as an important UGT isoform responsible for the glucuronidation of PTU.	Propylthiouracil	151-154	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	62-68
34832976-8	2021	Subsequently, the in vitro metabolism of PTU was assessed and UGT1A9 was identified as an important UGT isoform responsible for the glucuronidation of PTU.	Propylthiouracil	151-154	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	100-103
34234489-2	2021	Objective: This study was designed to assess the impact of propylthiouracil (PTU)-induced hypothyroidism on the pancreatic islet cells and the efficacy of thymoquinone (TQ) in alleviating this impact and explore the mechanism behind it alleviating oxidative stress and affecting beta-catenin expression.	Propylthiouracil	59-75	catenin beta 1	Rattus norvegicus	279-291
34234489-2	2021	Objective: This study was designed to assess the impact of propylthiouracil (PTU)-induced hypothyroidism on the pancreatic islet cells and the efficacy of thymoquinone (TQ) in alleviating this impact and explore the mechanism behind it alleviating oxidative stress and affecting beta-catenin expression.	Propylthiouracil	77-80	catenin beta 1	Rattus norvegicus	279-291
34234489-12	2021	Conclusion: TQ alleviated PTU-induced hypothyroidism changes in insulin homeostasis and pancreatic beta cells mostly through its antioxidant effect as well as up-regulation of pancreatic beta-catenin expression.	Propylthiouracil	26-29	catenin beta 1	Rattus norvegicus	187-199
2510176-6	1989	Plasma insulin-like growth factor levels were 16% lower (P less than 0.05) in PTU-fed birds than the other treatment groups.	Propylthiouracil	78-81	insulin	Gallus gallus	7-14
35101570-0	2022	Xiao-Luo-Wan treats propylthiouracil-induced goiter with hypothyroidism in rats through the PI3K-AKT/RAS pathways based on UPLC/MS and network pharmacology.	Propylthiouracil	20-36	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
35402762-7	2022	This HLA allele was previously detected in a patient with MIP and is one of the major risk factors for agranulocytosis induced by antithyroid drugs, including PTU as well as MMI.	Propylthiouracil	159-162	major histocompatibility complex, class II, DR beta 1	Homo sapiens	5-8
2591610-6	1989	Serum IgE level was decreased gradually after replacement of methimazole by propylthiouracil.	Propylthiouracil	76-92	immunoglobulin heavy constant epsilon	Homo sapiens	6-9
34257897-5	2021	We administered thyroxine to middle-aged (13 to 14 months) male and female mice to model hyperthyroidism and TH-lowering drugs propylthiouracil (PTU) and methimazole, to induce hypothyroidism.	Propylthiouracil	127-143	tyrosine hydroxylase	Mus musculus	109-111
34257897-5	2021	We administered thyroxine to middle-aged (13 to 14 months) male and female mice to model hyperthyroidism and TH-lowering drugs propylthiouracil (PTU) and methimazole, to induce hypothyroidism.	Propylthiouracil	145-148	tyrosine hydroxylase	Mus musculus	109-111
2510176-9	1989	Compared with the other treatments, dietary PTU increased (P less than 0.01) plasma insulin levels 4.3-fold whereas TRH provided a 2.7-fold increase in plasma insulin.	Propylthiouracil	44-47	insulin	Gallus gallus	84-91
2481575-1	1989	We have investigated the influence of antithyroid drugs (methimazole and propylthiouracil) and sodium iodide on the expression of major histocompatibility (MHC) class II antigen expression in human and rat thyroid cells.	Propylthiouracil	73-89	major histocompatibility complex, class II, DR beta 6 (pseudogene)	Homo sapiens	130-177
2791985-2	1989	Type I iodothyronine deiodinase activity was inhibited with propylthiouracil (PTU), and phenol sulfotransferase activity by SO4(2-) depletion or with competitive substrates or inhibitors.	Propylthiouracil	60-76	iodothyronine deiodinase 1	Rattus norvegicus	0-31
2791985-2	1989	Type I iodothyronine deiodinase activity was inhibited with propylthiouracil (PTU), and phenol sulfotransferase activity by SO4(2-) depletion or with competitive substrates or inhibitors.	Propylthiouracil	78-81	iodothyronine deiodinase 1	Rattus norvegicus	0-31
2764120-4	1989	Fetal offspring from methimazole-, and propylthiouracil-treated dams demonstrated significant increases in pulmonary superoxide dismutase activity at 20 and 21 days of gestation and in catalase and glutathione peroxidase activities at 21 days compared with control offspring.	Propylthiouracil	39-55	catalase	Rattus norvegicus	185-193
2917684-5	1989	Over the same period plasma renin activity increased in adrenalectomized rats from 4.1 +/- 0.8 to 7.0 +/- 1.5 pmol angiotensin I (AI)/ml/h, and decreased in propylthiouracil-treated rats from 3.8 +/- 0.4 to 1.6 +/- 0.4 pmol AI/ml/h.	Propylthiouracil	157-173	renin	Rattus norvegicus	28-33
2737156-9	1989	Deiodinations were sensitive to propylthiouracil inhibition, indicating the involvement of the type I iodothyronine deiodinase.	Propylthiouracil	32-48	iodothyronine deiodinase 1	Rattus norvegicus	95-126
2659308-4	1989	In addition to an anti-insulin antibody with a high binding capacity, hyperglucagonemia (260 pg/ml with a plasma glucose level of 61 mg/dl) was observed, which returned to normal in parallel with the decrease in the insulin binding capacity of the plasma one month after beginning the treatment with propylthiouracil.	Propylthiouracil	300-316	insulin	Homo sapiens	23-30
2659308-4	1989	In addition to an anti-insulin antibody with a high binding capacity, hyperglucagonemia (260 pg/ml with a plasma glucose level of 61 mg/dl) was observed, which returned to normal in parallel with the decrease in the insulin binding capacity of the plasma one month after beginning the treatment with propylthiouracil.	Propylthiouracil	300-316	insulin	Homo sapiens	216-223
2656249-0	1989	Metabolism of 35S- and 14C-labeled propylthiouracil in a model in vitro system containing thyroid peroxidase.	Propylthiouracil	35-51	thyroid peroxidase	Homo sapiens	90-108
2656249-1	1989	In previous communications we described an in vitro model system containing highly purified thyroid peroxidase (TPO) for studying the mechanism of inhibition of thyroid hormone biosynthesis by the antithyroid drugs, 6-propylthiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI).	Propylthiouracil	216-234	thyroid peroxidase	Homo sapiens	92-110
2656249-1	1989	In previous communications we described an in vitro model system containing highly purified thyroid peroxidase (TPO) for studying the mechanism of inhibition of thyroid hormone biosynthesis by the antithyroid drugs, 6-propylthiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI).	Propylthiouracil	216-234	thyroid peroxidase	Homo sapiens	112-115
2656249-1	1989	In previous communications we described an in vitro model system containing highly purified thyroid peroxidase (TPO) for studying the mechanism of inhibition of thyroid hormone biosynthesis by the antithyroid drugs, 6-propylthiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI).	Propylthiouracil	236-239	thyroid peroxidase	Homo sapiens	92-110
2656249-1	1989	In previous communications we described an in vitro model system containing highly purified thyroid peroxidase (TPO) for studying the mechanism of inhibition of thyroid hormone biosynthesis by the antithyroid drugs, 6-propylthiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI).	Propylthiouracil	236-239	thyroid peroxidase	Homo sapiens	112-115
2656249-15	1989	The identity of these desulfurated metabolites of PTU in the TPO model system remains to be determined.	Propylthiouracil	50-53	thyroid peroxidase	Homo sapiens	61-64
2656249-20	1989	In general, the metabolism of PTU by the TPO model system resembled that previously observed with MMI.	Propylthiouracil	30-33	thyroid peroxidase	Homo sapiens	41-44
2656250-0	1989	A reexamination of the proposed inactivation of thyroid peroxidase in the rat thyroid by propylthiouracil.	Propylthiouracil	89-105	thyroid peroxidase	Rattus norvegicus	48-66
2656250-4	1989	However, the analytical procedure used in our earlier study did not exclude the possibility that sufficient PTU remained in the thyroid even after 18 h to inhibit TPO-catalyzed iodination by a reversible mechanism.	Propylthiouracil	108-111	thyroid peroxidase	Rattus norvegicus	163-166
2656250-12	1989	Based on our view that TPO is the major mediator of intrathyroidal metabolism of PTU, this observation is inconsistent with our previous proposal that TPO is inactivated after PTU injection.	Propylthiouracil	81-84	thyroid peroxidase	Rattus norvegicus	23-26
2656250-12	1989	Based on our view that TPO is the major mediator of intrathyroidal metabolism of PTU, this observation is inconsistent with our previous proposal that TPO is inactivated after PTU injection.	Propylthiouracil	176-179	thyroid peroxidase	Rattus norvegicus	151-154
2656250-13	1989	The results of the present study, therefore, lead us to withdraw our previous suggestion that TPO is inactivated after injection of PTU into rats.	Propylthiouracil	132-135	thyroid peroxidase	Rattus norvegicus	94-97
2656250-14	1989	It is more likely that inhibition of iodination by PTU in the rat thyroid involves competition between PTU and tyrosyl residues of thyroglobulin for oxidized iodine, comparable to the reversible mechanism of inhibition observed in the TPO model system.	Propylthiouracil	51-54	thyroid peroxidase	Rattus norvegicus	235-238
2730567-12	1989	Inhibition by 6-n-propyl-2-thiouracil (Ki 6.7 microM) was competitive with respect to thioredoxin and non-competitive with respect to rT3, whereas inhibition by T4 (Ki 1.3 microM) was competitive.	Propylthiouracil	14-37	thioredoxin 1	Rattus norvegicus	86-97
2974798-3	1988	After treatment with methimazole or propylthiouracil, the plasma ANP concentration fell to normal in 4 patients, while it remained high in one patient who had persistent atrial fibrillation.	Propylthiouracil	36-52	natriuretic peptide A	Homo sapiens	65-68
2630312-3	1989	PTU decreased ODC activity in intact rats and inhibited ODC activity in animals treated with T4.	Propylthiouracil	0-3	ornithine decarboxylase 1	Rattus norvegicus	14-17
2630312-3	1989	PTU decreased ODC activity in intact rats and inhibited ODC activity in animals treated with T4.	Propylthiouracil	0-3	ornithine decarboxylase 1	Rattus norvegicus	56-59
3193044-1	1988	The possible involvement of a deficit of GH and insulin-like growth factor-I (somatomedin C) (IGF-I/SMC) in mediating the effects of propylthiouracil (PTU)-induced hypothyroidism on body and skeletal growth and myelination was studied in the neonatal rat.	Propylthiouracil	133-149	insulin-like growth factor 1	Rattus norvegicus	48-76
3193044-1	1988	The possible involvement of a deficit of GH and insulin-like growth factor-I (somatomedin C) (IGF-I/SMC) in mediating the effects of propylthiouracil (PTU)-induced hypothyroidism on body and skeletal growth and myelination was studied in the neonatal rat.	Propylthiouracil	133-149	insulin-like growth factor 1	Rattus norvegicus	94-99
3193044-1	1988	The possible involvement of a deficit of GH and insulin-like growth factor-I (somatomedin C) (IGF-I/SMC) in mediating the effects of propylthiouracil (PTU)-induced hypothyroidism on body and skeletal growth and myelination was studied in the neonatal rat.	Propylthiouracil	151-154	insulin-like growth factor 1	Rattus norvegicus	48-76
3193044-2	1988	Myelination (as assessed by 2",3"-cyclic nucleotide 3"-phosphohydrolase (CNP) activity), skeletal growth (as assessed by tail length) and body weight of pups from PTU-treated mothers were significantly retarded compared with normal animals or euthyroid controls.	Propylthiouracil	163-166	2',3'-cyclic nucleotide 3' phosphodiesterase	Rattus norvegicus	28-71
2837228-1	1988	Myeloperoxidase and eosinophil peroxidase were isolated from the bone marrow cells of rats treated with or without propylthiouracil (PTU) which caused bone marrow depression.	Propylthiouracil	115-131	myeloperoxidase	Rattus norvegicus	0-15
2837228-1	1988	Myeloperoxidase and eosinophil peroxidase were isolated from the bone marrow cells of rats treated with or without propylthiouracil (PTU) which caused bone marrow depression.	Propylthiouracil	133-136	myeloperoxidase	Rattus norvegicus	0-15
2837228-2	1988	PTU treatment decreased the activity of myeloperoxidase but not of eosinophil peroxidase using guaiacol as the electron donor.	Propylthiouracil	0-3	myeloperoxidase	Homo sapiens	40-55
2837228-4	1988	EPR spectra indicated that the structure of myeloperoxidase surrounding the heme iron changed from a rhombic form into an axial one by the repeated administration of PTU.	Propylthiouracil	166-169	myeloperoxidase	Rattus norvegicus	44-59
2853896-2	1988	Propylthiouracil (PTU) was degraded by myeloperoxidase (MPO) or eosinophil peroxidase (EPO), purified from rat bone marrow, in the presence of H2O2 and Cl-.	Propylthiouracil	0-16	myeloperoxidase	Rattus norvegicus	39-54
2853896-2	1988	Propylthiouracil (PTU) was degraded by myeloperoxidase (MPO) or eosinophil peroxidase (EPO), purified from rat bone marrow, in the presence of H2O2 and Cl-.	Propylthiouracil	0-16	myeloperoxidase	Rattus norvegicus	56-59
2853896-2	1988	Propylthiouracil (PTU) was degraded by myeloperoxidase (MPO) or eosinophil peroxidase (EPO), purified from rat bone marrow, in the presence of H2O2 and Cl-.	Propylthiouracil	0-16	eosinophil peroxidase	Rattus norvegicus	64-85
2853896-2	1988	Propylthiouracil (PTU) was degraded by myeloperoxidase (MPO) or eosinophil peroxidase (EPO), purified from rat bone marrow, in the presence of H2O2 and Cl-.	Propylthiouracil	0-16	eosinophil peroxidase	Rattus norvegicus	87-90
2853896-2	1988	Propylthiouracil (PTU) was degraded by myeloperoxidase (MPO) or eosinophil peroxidase (EPO), purified from rat bone marrow, in the presence of H2O2 and Cl-.	Propylthiouracil	18-21	myeloperoxidase	Rattus norvegicus	39-54
2853896-2	1988	Propylthiouracil (PTU) was degraded by myeloperoxidase (MPO) or eosinophil peroxidase (EPO), purified from rat bone marrow, in the presence of H2O2 and Cl-.	Propylthiouracil	18-21	myeloperoxidase	Rattus norvegicus	56-59
2853896-2	1988	Propylthiouracil (PTU) was degraded by myeloperoxidase (MPO) or eosinophil peroxidase (EPO), purified from rat bone marrow, in the presence of H2O2 and Cl-.	Propylthiouracil	18-21	eosinophil peroxidase	Rattus norvegicus	64-85
2853896-2	1988	Propylthiouracil (PTU) was degraded by myeloperoxidase (MPO) or eosinophil peroxidase (EPO), purified from rat bone marrow, in the presence of H2O2 and Cl-.	Propylthiouracil	18-21	eosinophil peroxidase	Rattus norvegicus	87-90
2853896-6	1988	The characteristics of PTU degradation by MPO-H2O2-Cl- were similar to those of the chlorinating activity of the peroxidase.	Propylthiouracil	23-26	myeloperoxidase	Rattus norvegicus	42-45
2853896-8	1988	Hypochlorous acid as well as MPO-H2O2-Cl- also degraded PTU.	Propylthiouracil	56-59	myeloperoxidase	Rattus norvegicus	29-32
2853896-9	1988	Metabolites of PTU degradation by MPO-H2O2-Cl-, which were separated by C18 reversed phase h.p.l.c., were the same as those produced by hypochlorous acid.	Propylthiouracil	15-18	myeloperoxidase	Rattus norvegicus	34-37
2853896-11	1988	Of the metabolites of PTU formed by MPO-H2O2-Cl-, one was identified as PTU sulphonic acid (6-propyl-4-hydroxypyrimidine-2-sulphonate) and another seemed to be propyluracil.	Propylthiouracil	22-25	myeloperoxidase	Rattus norvegicus	36-39
3320054-3	1987	10 wk on a propylthiouracil diet down-regulates expression of alpha-MHC to near 0%.	Propylthiouracil	11-27	myosin-6-like	Oryctolagus cuniculus	62-71
3117986-1	1987	Mice given propylthiouracil, a thyroid inhibitor, and fed a diet containing a nontoxic level of rac-1(3)-palmitoyl glycerol showed the hypothermia and mortality expected for a toxic dose, but did not show these signs when linoleate or oleate was added to the diet.	Propylthiouracil	11-27	Rac family small GTPase 1	Mus musculus	96-101
2893705-6	1987	Indomethacin and aspirin, inhibitors of the cyclooxygenase component of PHS, and propylthiouracil and methimazole, inhibitors of the hydroperoxidase component of PHS, inhibited the arachidonic acid-supported covalent binding of [14C]2-bromohydroquinone by 94%, 52%, 78%, and 79% respectively.	Propylthiouracil	81-97	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	162-165
3595535-10	1987	Even though it is possible to inhibit the type II 5"-deiodinase activity with high concentrations of PTU (in the presence of low DTT concentrations), the deiodinase in kidney is about 1000-fold more sensitive to PTU.	Propylthiouracil	101-104	iodothyronine deiodinase 2	Rattus norvegicus	42-63
3118365-3	1987	Chemical thyroidectomy, produced by the administration of 6-(n-propyl)-2-thiouracil (PrSur), reduced plasma thyroxine below detection limits and significantly increased TRH mRNA in the paraventricular nucleus.	Propylthiouracil	58-83	thyrotropin releasing hormone	Rattus norvegicus	169-172
3595535-10	1987	Even though it is possible to inhibit the type II 5"-deiodinase activity with high concentrations of PTU (in the presence of low DTT concentrations), the deiodinase in kidney is about 1000-fold more sensitive to PTU.	Propylthiouracil	212-215	iodothyronine deiodinase 2	Rattus norvegicus	42-63
3116140-6	1987	Hypothyroidism induced by PTU significantly increased TRH-IR and TRH-Gly-IR levels in prostate and testis and reduced these levels in epididymis but did not affect the serum concentrations of testosterone compared with those of controls.	Propylthiouracil	26-29	thyrotropin releasing hormone	Rattus norvegicus	54-57
3116140-6	1987	Hypothyroidism induced by PTU significantly increased TRH-IR and TRH-Gly-IR levels in prostate and testis and reduced these levels in epididymis but did not affect the serum concentrations of testosterone compared with those of controls.	Propylthiouracil	26-29	thyrotropin releasing hormone	Rattus norvegicus	65-68
3112298-7	1987	The effects of dietary propylthiouracil on the hepatic mRNA levels for apolipoproteins A-I and A-IV imply a role for thyroid hormones in regulating the mRNA levels for these apolipoproteins in rat liver.	Propylthiouracil	23-39	apolipoprotein E	Rattus norvegicus	71-86
3112298-8	1987	ApoE mRNA levels in the rat liver decreased slightly after the CF-PTU diet (74 +/- 12% of normal) and after the PTU diet (73 +/- 10% of normal).	Propylthiouracil	66-69	apolipoprotein E	Rattus norvegicus	0-4
2435102-2	1987	The current in vitro study shows that 3,4-DHP, like MMI and PTU, inhibits iodination of human thyroglobulin and interferes with mitogenic activation of human lymphocytes.	Propylthiouracil	60-63	dihydropyrimidinase	Homo sapiens	42-45
3574606-3	1987	Adult animals treated with propylthiouracil (PTU; 0.2% in the mother"s food), a thyroid hormone synthesis inhibitor, for the first 2 weeks of life showed decreased glucocorticoid receptor concentrations in hippocampus, but not in hypothalamus or pituitary.	Propylthiouracil	27-43	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	164-187
3574606-3	1987	Adult animals treated with propylthiouracil (PTU; 0.2% in the mother"s food), a thyroid hormone synthesis inhibitor, for the first 2 weeks of life showed decreased glucocorticoid receptor concentrations in hippocampus, but not in hypothalamus or pituitary.	Propylthiouracil	45-48	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	164-187
3574606-6	1987	PTU administration blocked the effects of handling, such that Ha/PTU animals showed hippocampal glucocorticoid receptor concentrations that were indistinguishable from those of NHa animals.	Propylthiouracil	0-3	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	96-119
3528517-4	1986	A causal link between PTU treatment and the cholestatic jaundice was suggested by: the time of onset, typical skin rash and a positive migration inhibition factor (MIF) test to PTU.	Propylthiouracil	22-25	macrophage migration inhibitory factor	Homo sapiens	135-162
3803575-0	1986	Propylthiouracil, a selective inhibitor of NADH-cytochrome b5 reductase.	Propylthiouracil	0-16	cytochrome b5 type A	Rattus norvegicus	48-61
3803575-1	1986	Propylthiouracil inhibited the activity of NADH-cytochrome b5 reductase of rat liver microsomes using potassium ferricyanide as electron acceptor.	Propylthiouracil	0-16	cytochrome b5 type A	Rattus norvegicus	48-61
3803575-3	1986	NADH-supported reduction of cytochrome b5 was also inhibited by propylthiouracil in the reconstituted system consisting of cytochrome b5 and partially purified NADH-cytochrome b5 reductase.	Propylthiouracil	64-80	cytochrome b5 type A	Rattus norvegicus	28-41
2942390-6	1986	The findings in this study suggest 1) that acetylation of pituitary and thyroid beta EP is similarly sensitive to PTU and thyroid hormone administration and 2) that in the thyroid, but not in the pituitary, both PTU and thyroid hormones markedly lower levels of pro-opiomelanocortin-derived peptides.	Propylthiouracil	212-215	proopiomelanocortin	Rattus norvegicus	262-282
3096042-4	1986	In the adult male rat experimental hypothyroidism produced by ingestion of propylthiouracil depresses the GH secretory response to GH-releasing hormone in vivo and in vitro, reflecting the lowered pituitary stores of GH in the hypothyroid state.	Propylthiouracil	75-91	gonadotropin releasing hormone receptor	Rattus norvegicus	106-108
3096042-4	1986	In the adult male rat experimental hypothyroidism produced by ingestion of propylthiouracil depresses the GH secretory response to GH-releasing hormone in vivo and in vitro, reflecting the lowered pituitary stores of GH in the hypothyroid state.	Propylthiouracil	75-91	gonadotropin releasing hormone receptor	Rattus norvegicus	131-133
3096042-4	1986	In the adult male rat experimental hypothyroidism produced by ingestion of propylthiouracil depresses the GH secretory response to GH-releasing hormone in vivo and in vitro, reflecting the lowered pituitary stores of GH in the hypothyroid state.	Propylthiouracil	75-91	gonadotropin releasing hormone receptor	Rattus norvegicus	131-133
2952571-2	1987	The effects of propylthiouracil (PTU) treatment on renal vasopressin sensitive adenylate cyclase in young and adult rats were studied by measuring the binding of tritiated vasopressin and adenylate cyclase activation by vasopressin in kidney medulla plasma membranes.	Propylthiouracil	15-31	arginine vasopressin	Rattus norvegicus	57-68
2952571-2	1987	The effects of propylthiouracil (PTU) treatment on renal vasopressin sensitive adenylate cyclase in young and adult rats were studied by measuring the binding of tritiated vasopressin and adenylate cyclase activation by vasopressin in kidney medulla plasma membranes.	Propylthiouracil	15-31	arginine vasopressin	Rattus norvegicus	172-183
2952571-2	1987	The effects of propylthiouracil (PTU) treatment on renal vasopressin sensitive adenylate cyclase in young and adult rats were studied by measuring the binding of tritiated vasopressin and adenylate cyclase activation by vasopressin in kidney medulla plasma membranes.	Propylthiouracil	15-31	arginine vasopressin	Rattus norvegicus	172-183
2952571-2	1987	The effects of propylthiouracil (PTU) treatment on renal vasopressin sensitive adenylate cyclase in young and adult rats were studied by measuring the binding of tritiated vasopressin and adenylate cyclase activation by vasopressin in kidney medulla plasma membranes.	Propylthiouracil	33-36	arginine vasopressin	Rattus norvegicus	57-68
2952571-2	1987	The effects of propylthiouracil (PTU) treatment on renal vasopressin sensitive adenylate cyclase in young and adult rats were studied by measuring the binding of tritiated vasopressin and adenylate cyclase activation by vasopressin in kidney medulla plasma membranes.	Propylthiouracil	33-36	arginine vasopressin	Rattus norvegicus	172-183
2952571-2	1987	The effects of propylthiouracil (PTU) treatment on renal vasopressin sensitive adenylate cyclase in young and adult rats were studied by measuring the binding of tritiated vasopressin and adenylate cyclase activation by vasopressin in kidney medulla plasma membranes.	Propylthiouracil	33-36	arginine vasopressin	Rattus norvegicus	172-183
2952571-3	1987	Thyroxine therapy completely corrected the effects of PTU treatment on the vasopressin-adenylate cyclase system.	Propylthiouracil	54-57	arginine vasopressin	Rattus norvegicus	75-86
3297964-5	1987	A summary of structure-activity relationships of greater than 200 naturally occurring and synthetic ligands of rat liver type I iodothyronine deiodinase isozyme propylthiouracil-sensitive) in vitro allows the design of iodothyronine analogues which either serve as specific substrates or antagonists of iodothyronine binding and metabolizing proteins.	Propylthiouracil	161-177	iodothyronine deiodinase 1	Rattus norvegicus	121-152
3803575-3	1986	NADH-supported reduction of cytochrome b5 was also inhibited by propylthiouracil in the reconstituted system consisting of cytochrome b5 and partially purified NADH-cytochrome b5 reductase.	Propylthiouracil	64-80	cytochrome b5 type A	Rattus norvegicus	123-136
3803575-3	1986	NADH-supported reduction of cytochrome b5 was also inhibited by propylthiouracil in the reconstituted system consisting of cytochrome b5 and partially purified NADH-cytochrome b5 reductase.	Propylthiouracil	64-80	cytochrome b5 type A	Rattus norvegicus	123-136
3084458-2	1986	Treatment with steroids, propylthiouracil, propranolol, iodine, and plasmapheresis was associated with dramatic reduction in serum triiodothyronine (T3), serum thyroxine (T4), and thyroglobulin levels and prompt recovery of the patient.	Propylthiouracil	25-41	thyroglobulin	Homo sapiens	180-193
3528517-4	1986	A causal link between PTU treatment and the cholestatic jaundice was suggested by: the time of onset, typical skin rash and a positive migration inhibition factor (MIF) test to PTU.	Propylthiouracil	22-25	macrophage migration inhibitory factor	Homo sapiens	164-167
3930003-2	1985	The localization of neurons containing immunoreactive thyrotropin-releasing hormone (TRH) was examined in the hypothalamus of intact, propylthiouracil (PTU)-treated, and colchicine-treated adult rats.	Propylthiouracil	134-150	thyrotropin releasing hormone	Rattus norvegicus	85-88
3930003-2	1985	The localization of neurons containing immunoreactive thyrotropin-releasing hormone (TRH) was examined in the hypothalamus of intact, propylthiouracil (PTU)-treated, and colchicine-treated adult rats.	Propylthiouracil	152-155	thyrotropin releasing hormone	Rattus norvegicus	85-88
3838997-12	1985	Methimazole (MMI) and PTU had similar potencies in inhibiting the TPO-catalyzed coupling reaction, whereas MMI was distinctly more potent than PTU as an inhibitor of TPO-mediated iodination in vitro.	Propylthiouracil	22-25	thyroid peroxidase	Homo sapiens	66-69
3160353-3	1985	Treatment with the antithyroid drug 6-n-propyl-2-thiouracil (PTU) during the last 9 days (40 mg/kg/day) of the chronic administration of ethanol reduced hepatic oxygen consumption, resulting in a net diminution of the metabolic tolerance to ethanol, despite a further elevation in ADH activity.	Propylthiouracil	36-59	aldo-keto reductase family 1 member A1	Rattus norvegicus	281-284
3160353-3	1985	Treatment with the antithyroid drug 6-n-propyl-2-thiouracil (PTU) during the last 9 days (40 mg/kg/day) of the chronic administration of ethanol reduced hepatic oxygen consumption, resulting in a net diminution of the metabolic tolerance to ethanol, despite a further elevation in ADH activity.	Propylthiouracil	61-64	aldo-keto reductase family 1 member A1	Rattus norvegicus	281-284
4018393-3	1985	On the other hand, in Tgb samples synthesized by propylthiouracil-blocked glands, the I:D regression is no longer linear.	Propylthiouracil	49-65	thyroglobulin	Rattus norvegicus	22-25
3838997-4	1985	Thyroglobulin with low thyroid hormone content was obtained from Grave"s and follicular adenoma tissues after propylthiouracil (PTU) therapy and L-T4 therapy, respectively.	Propylthiouracil	110-126	thyroglobulin	Homo sapiens	0-13
3838997-4	1985	Thyroglobulin with low thyroid hormone content was obtained from Grave"s and follicular adenoma tissues after propylthiouracil (PTU) therapy and L-T4 therapy, respectively.	Propylthiouracil	128-131	thyroglobulin	Homo sapiens	0-13
3838997-12	1985	Methimazole (MMI) and PTU had similar potencies in inhibiting the TPO-catalyzed coupling reaction, whereas MMI was distinctly more potent than PTU as an inhibitor of TPO-mediated iodination in vitro.	Propylthiouracil	143-146	thyroid peroxidase	Homo sapiens	166-169
24874596-1	1985	The influence of neonatal hypothyroidism on the development of immunoreactivity to glial fibrillary acidic protein (GFA) was studied in parietal cortex of rats treated from birth with the antithyroid agent propylthiouracil (PTU) for 3 or 8 weeks.	Propylthiouracil	206-222	glial fibrillary acidic protein	Rattus norvegicus	83-114
2986465-8	1985	[32P]Pi incorporation into phosphatidylinositol by epinephrine and vasopressin in 28-day propylthiouracil-treated rats was lower than the control (P less than 0.01).	Propylthiouracil	89-105	arginine vasopressin	Rattus norvegicus	67-78
24874596-1	1985	The influence of neonatal hypothyroidism on the development of immunoreactivity to glial fibrillary acidic protein (GFA) was studied in parietal cortex of rats treated from birth with the antithyroid agent propylthiouracil (PTU) for 3 or 8 weeks.	Propylthiouracil	206-222	glial fibrillary acidic protein	Rattus norvegicus	116-119
24874596-3	1985	Three weeks postnatally, the density of GFA-immunoreactive structures in the cortical layers II-V was 70% lower in PTU-treated animals than in controls injected with the solvent.	Propylthiouracil	115-118	glial fibrillary acidic protein	Rattus norvegicus	40-43
24874596-5	1985	The inhibited development of GFA immunoreactivity was not persistent in animals treated with PTU for 8 weeks continuously.	Propylthiouracil	93-96	glial fibrillary acidic protein	Rattus norvegicus	29-32
6509376-3	1984	Conversely, ODC activity was decreased in 2- and 5-day-old hypothyroid rats (propylthiouracil to the mother), but it was not significantly different from normal thereafter.	Propylthiouracil	77-93	ornithine decarboxylase 1	Rattus norvegicus	12-15
6438427-0	1984	Selective induction of cytochrome b5 and NADH cytochrome b5 reductase by propylthiouracil.	Propylthiouracil	73-89	cytochrome b5 type A	Rattus norvegicus	23-36
6438427-0	1984	Selective induction of cytochrome b5 and NADH cytochrome b5 reductase by propylthiouracil.	Propylthiouracil	73-89	cytochrome b5 type A	Rattus norvegicus	46-59
6438427-6	1984	From the above evidence, repeated administration of PTU selectively induced cytochrome b5 and NADH cytochrome b5 reductase in rat liver microsomes.	Propylthiouracil	52-55	cytochrome b5 type A	Rattus norvegicus	76-89
6438427-6	1984	From the above evidence, repeated administration of PTU selectively induced cytochrome b5 and NADH cytochrome b5 reductase in rat liver microsomes.	Propylthiouracil	52-55	cytochrome b5 type A	Rattus norvegicus	99-112
6723573-4	1984	PTU abolished the effect of T4 on alpha GPD and markedly reduced its effect on 3",5"-T2 MA and ODC activity; it had little effect on cardiac hypertrophy caused by T4 treatment.	Propylthiouracil	0-3	ornithine decarboxylase 1	Rattus norvegicus	95-98
6096612-0	1984	Relationship between leukopenia and bone marrow myeloperoxidase in the rat treated with propylthiouracil.	Propylthiouracil	88-104	myeloperoxidase	Rattus norvegicus	48-63
6096612-1	1984	The relationship between the toxic effect of propylthiouracil (PTU) and myeloperoxidase activity of rat bone marrow was examined.	Propylthiouracil	45-61	myeloperoxidase	Rattus norvegicus	72-87
6096612-1	1984	The relationship between the toxic effect of propylthiouracil (PTU) and myeloperoxidase activity of rat bone marrow was examined.	Propylthiouracil	63-66	myeloperoxidase	Rattus norvegicus	72-87
6096612-2	1984	The administration of PTU for 1 or 2 weeks caused a decrease in leukocyte count with the concomitant inhibition of the activity of myeloperoxidase in the bone marrow.	Propylthiouracil	22-25	myeloperoxidase	Rattus norvegicus	131-146
6096612-6	1984	The results suggest that the mechanism of inhibition of myeloperoxidase activity by PTU given in vivo or incubated with the enzyme in vitro may be the same.	Propylthiouracil	84-87	myeloperoxidase	Rattus norvegicus	56-71
6399210-4	1984	The administration of 6-n-propyl-2-thiouracil (PTU), which was previously found to reduce hepatic oxygen consumption and to increase ADH activity, resulted in no change in the rate of ethanol metabolism in the ethanol-fed rats and an increase in the sucrose-fed controls, suggesting that increased ADH activity is more important for the development of metabolic tolerance to ethanol, in the male SH rat, than increased oxygen consumption.	Propylthiouracil	22-45	aldo-keto reductase family 1 member A1	Rattus norvegicus	133-136
6399210-4	1984	The administration of 6-n-propyl-2-thiouracil (PTU), which was previously found to reduce hepatic oxygen consumption and to increase ADH activity, resulted in no change in the rate of ethanol metabolism in the ethanol-fed rats and an increase in the sucrose-fed controls, suggesting that increased ADH activity is more important for the development of metabolic tolerance to ethanol, in the male SH rat, than increased oxygen consumption.	Propylthiouracil	22-45	aldo-keto reductase family 1 member A1	Rattus norvegicus	298-301
6399210-4	1984	The administration of 6-n-propyl-2-thiouracil (PTU), which was previously found to reduce hepatic oxygen consumption and to increase ADH activity, resulted in no change in the rate of ethanol metabolism in the ethanol-fed rats and an increase in the sucrose-fed controls, suggesting that increased ADH activity is more important for the development of metabolic tolerance to ethanol, in the male SH rat, than increased oxygen consumption.	Propylthiouracil	47-50	aldo-keto reductase family 1 member A1	Rattus norvegicus	133-136
24873959-3	1984	Activity of cardiac ODC was depressed in the PTU-treated group and putrescine and spermidine levels were markedly subnormal.	Propylthiouracil	45-48	ornithine decarboxylase 1	Rattus norvegicus	20-23
6464504-0	1984	Enhancement of glutathione S-transferase activity in rat liver by repeated administration of propylthiouracil.	Propylthiouracil	93-109	hematopoietic prostaglandin D synthase	Rattus norvegicus	15-40
6464504-1	1984	Treatment of rats with propylthiouracil for one to two weeks caused an increase in glutathione S-transferase (GST) activity of the liver cytosol, but not of the particulate fraction.	Propylthiouracil	23-39	hematopoietic prostaglandin D synthase	Rattus norvegicus	83-108
6464504-1	1984	Treatment of rats with propylthiouracil for one to two weeks caused an increase in glutathione S-transferase (GST) activity of the liver cytosol, but not of the particulate fraction.	Propylthiouracil	23-39	hematopoietic prostaglandin D synthase	Rattus norvegicus	110-113
6707550-1	1984	Serum thyroglobulin (Tg), measured by radioimmunoassay, was high in 6-propylthiouracil (PTU)-treated rats but low in thyroxine (T4)-treated animals compared with euthyroid controls.	Propylthiouracil	68-86	thyroglobulin	Rattus norvegicus	6-19
6707550-1	1984	Serum thyroglobulin (Tg), measured by radioimmunoassay, was high in 6-propylthiouracil (PTU)-treated rats but low in thyroxine (T4)-treated animals compared with euthyroid controls.	Propylthiouracil	68-86	thyroglobulin	Rattus norvegicus	21-23
6707550-1	1984	Serum thyroglobulin (Tg), measured by radioimmunoassay, was high in 6-propylthiouracil (PTU)-treated rats but low in thyroxine (T4)-treated animals compared with euthyroid controls.	Propylthiouracil	88-91	thyroglobulin	Rattus norvegicus	6-19
6707550-1	1984	Serum thyroglobulin (Tg), measured by radioimmunoassay, was high in 6-propylthiouracil (PTU)-treated rats but low in thyroxine (T4)-treated animals compared with euthyroid controls.	Propylthiouracil	88-91	thyroglobulin	Rattus norvegicus	21-23
6707550-3	1984	Thyroid cells prepared from T4-treated animals behaved similarly to cells from control rats, whereas in vitro basal release of Tg from thyroid cells prepared from PTU-treated animals was high and the response to TSH was lost.	Propylthiouracil	163-166	thyroglobulin	Rattus norvegicus	127-129
6089134-12	1984	Hypothyroidism, provoked in rat by thyroidectomy or propylthiouracil treatment, again induced a marked decrease in secretin-stimulated cardiac adenylate cyclase activity.	Propylthiouracil	52-68	secretin	Rattus norvegicus	115-123
6847836-3	1983	1) TPO is inactivated by 1-methyl-2-mercaptoimidazole and propylthiouracil even in the presence of a relatively high concentration of iodide.	Propylthiouracil	58-74	thyroid peroxidase	Homo sapiens	3-6
6861708-0	1983	Mechanism of action of thioureylene antithyroid drugs in the rat: possible inactivation of thyroid peroxidase by propylthiouracil.	Propylthiouracil	113-129	thyroid peroxidase	Rattus norvegicus	91-109
6861708-1	1983	We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide.	Propylthiouracil	65-86	thyroid peroxidase	Rattus norvegicus	147-165
6861708-1	1983	We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide.	Propylthiouracil	65-86	thyroid peroxidase	Rattus norvegicus	167-170
6861708-1	1983	We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide.	Propylthiouracil	88-91	thyroid peroxidase	Rattus norvegicus	147-165
6861708-1	1983	We have previously shown that the thioureylene antithyroid drugs 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) can inactivate thyroid peroxidase (TPO) in a model iodination system containing relatively high concentrations of iodide.	Propylthiouracil	88-91	thyroid peroxidase	Rattus norvegicus	167-170
6418878-6	1983	This study provides the first demonstration of inhibition of PHS-activated benzidine binding by propylthiouracil, methimazole, MK447, vitamin C and phenidone.	Propylthiouracil	96-112	pterin-4 alpha-carbinolamine dehydratase 1	Homo sapiens	61-64
6833495-7	1983	ELC was enhanced by the catalase inhibitor aminotriazole, and was inhibited by the peroxidase inhibitor propylthiouracil, suggesting that the enzyme is a peroxidase and that hydrogen peroxide (H(2)O(2)) is a necessary cofactor in the reaction.	Propylthiouracil	104-120	C-C motif chemokine ligand 19	Homo sapiens	0-3
6600164-6	1983	Induction of experimental hypothyroidism with propylthiouracil (PTU) and methimazole produced a relative decrease in skin EGF levels on postnatal day 8.	Propylthiouracil	46-62	epidermal growth factor	Mus musculus	122-125
6600164-6	1983	Induction of experimental hypothyroidism with propylthiouracil (PTU) and methimazole produced a relative decrease in skin EGF levels on postnatal day 8.	Propylthiouracil	64-67	epidermal growth factor	Mus musculus	122-125
7148337-3	1982	Following maternal treatment with propylthiouracil (PTU), the TPO activity markedly increased in foetuses on and after day 20 of gestation.	Propylthiouracil	52-55	thyroid peroxidase	Rattus norvegicus	62-65
6186257-1	1982	We have investigated the mechanism by which the thioureylene drugs, 1-methyl-2-mercaptoimidazole (MMI) and 6-n-propylthiouracil (PTU), inactivate thyroid peroxidase (TPO).	Propylthiouracil	107-127	thyroid peroxidase	Homo sapiens	146-164
6186257-1	1982	We have investigated the mechanism by which the thioureylene drugs, 1-methyl-2-mercaptoimidazole (MMI) and 6-n-propylthiouracil (PTU), inactivate thyroid peroxidase (TPO).	Propylthiouracil	129-132	thyroid peroxidase	Homo sapiens	146-164
7148337-3	1982	Following maternal treatment with propylthiouracil (PTU), the TPO activity markedly increased in foetuses on and after day 20 of gestation.	Propylthiouracil	34-50	thyroid peroxidase	Rattus norvegicus	62-65
6896112-0	1982	A prospective study of the differential changes in serum thyroglobulin and its autoantibodies during propylthiouracil or radioiodine therapy of patients with Graves" disease.	Propylthiouracil	101-117	thyroglobulin	Homo sapiens	57-70
7148337-5	1982	Newborn rats nursed by mothers treated with PTU had a TPO activity similar to that in controls of untreated mothers.	Propylthiouracil	44-47	thyroid peroxidase	Rattus norvegicus	54-57
6816881-4	1982	Although in the mildly hypothyroid animals (propylthiouracil-treated), hepatic metabolism of free fatty acid is shifted toward esterification to triglyceride and VLDL formation, as we reported previously, plasma HDL and apoA-I concentrations were not different from control plasma values, while the d 1.006-1.063 g/ml (IDL + LDL) lipoprotein fraction tended to be increased.	Propylthiouracil	44-60	apolipoprotein A1	Rattus norvegicus	220-226
6816881-7	1982	The depressed net output of apoA-I in vitro by perfused livers from rats treated with propylthiouracil (PTU) was not expressed in a statistically significant diminished plasma concentration of HDL or apoA-I in the intact animals.	Propylthiouracil	86-102	apolipoprotein A1	Rattus norvegicus	28-34
6816881-7	1982	The depressed net output of apoA-I in vitro by perfused livers from rats treated with propylthiouracil (PTU) was not expressed in a statistically significant diminished plasma concentration of HDL or apoA-I in the intact animals.	Propylthiouracil	104-107	apolipoprotein A1	Rattus norvegicus	28-34
6896112-5	1982	PTU caused only minor changes in the serum Tg concentration.	Propylthiouracil	0-3	thyroglobulin	Homo sapiens	43-45
6787114-4	1981	The loss in immunostaining in the PTU-treated rats was correlated with radioimmunoassay (RIA) measurements that showed a 65% reduction in anterior pituitary TRH content after 34, 70, and 98 days of PTU treatment (from 22.9--7.8 pg/mg wet wt) and a 50% reduction in TSH content after 34 days of treatment.	Propylthiouracil	34-37	thyrotropin releasing hormone	Rattus norvegicus	157-160
7053983-0	1982	Preferential inhibition of thyroxine and 3,5,3"-triiodothyronine formation by propylthiouracil and methylmercaptoimidazole in thyroid peroxidase-catalyzed iodination of thyroglobulin.	Propylthiouracil	78-94	thyroid peroxidase	Homo sapiens	126-144
7053983-10	1982	In the case of PTU, a specific inhibitory effect on coupling was also demonstrated with an incubation system in which TPO-catalyzed coupling was measured in the absence of iodination.	Propylthiouracil	15-18	thyroid peroxidase	Homo sapiens	118-121
7058886-4	1982	In propylthiouracil-induced hypothyroid pups, the developmental rise of both CBG and corticosterone was suppressed.	Propylthiouracil	3-19	serpin family A member 6	Rattus norvegicus	77-80
7223883-6	1981	Conversely, in pups made hypothyroid by administration of propylthiouracil, the normal ontogenic increase in CBG was suppressed.	Propylthiouracil	58-74	serpin family A member 6	Rattus norvegicus	109-112
6787114-6	1981	In this study, the radioimmunoassay showed that TSH content rose dramatically in the hypothyroid animals treated with PTU for 77 days and thyroxine for 2 days before death (from 8.5--64.1 mU/mg wet wt); however, the rise in TRH content was minimal (5.8--9.8 pg/mg wet wt).	Propylthiouracil	118-121	thyrotropin releasing hormone	Rattus norvegicus	224-227
6776220-6	1980	Pituitary concentrations of growth hormone, TSH, prolactin and FSH were significantly reduced by the treatment with PTU.	Propylthiouracil	116-119	gonadotropin releasing hormone receptor	Rattus norvegicus	28-42
6776220-6	1980	Pituitary concentrations of growth hormone, TSH, prolactin and FSH were significantly reduced by the treatment with PTU.	Propylthiouracil	116-119	prolactin	Rattus norvegicus	49-58
109291-3	1978	Similarly, the increased plasma TSH level following PTU treatment was significantly suppressed after iv injection of antiserum to TRH.	Propylthiouracil	52-55	thyrotropin releasing hormone	Rattus norvegicus	130-133
7355663-0	1980	Effects of propylthiouracil and methylmercaptoimidazole on thyroglobulin synthesis.	Propylthiouracil	11-27	thyroglobulin	Rattus norvegicus	59-72
7355663-6	1980	In vitro studies demonstrate that PTU and MMI inhibit Tg biosynthesis which is impaired in the polypeptide synthesis as well as in carbohydrate chains addition.	Propylthiouracil	34-37	thyroglobulin	Rattus norvegicus	54-56
436752-5	1979	Normal adult rats, treated with propylthiouracil for 60 days, also weighed considerably less than control animals and exhibited a significant drop in serum GH, IGF, and CP during this period.	Propylthiouracil	32-48	insulin-like growth factor 1	Rattus norvegicus	160-163
436767-1	1979	Thiourea, methylmercaptoimidazole, propylthiouracil, and thiouracil are all potent inhibitors of thyroid peroxidase (TPO)-catalyzed iodination.	Propylthiouracil	35-51	thyroid peroxidase	Rattus norvegicus	97-115
436767-1	1979	Thiourea, methylmercaptoimidazole, propylthiouracil, and thiouracil are all potent inhibitors of thyroid peroxidase (TPO)-catalyzed iodination.	Propylthiouracil	35-51	thyroid peroxidase	Rattus norvegicus	117-120
7357457-9	1980	Propylthiouracil treatment (0.05% PTU in the drinking water for 21 days) led to a marked increase in thyroid gland weight (550% of control) but had no significant effect on NGF concentration in any of the organs studied with the exception of kidney where a 75% reduction in NGF concentration was observed.	Propylthiouracil	0-16	nerve growth factor	Mus musculus	274-277
6245995-3	1980	Plasma glucagon level was significantly decreased and insulin significantly increased after two days of PTU administration.	Propylthiouracil	104-107	insulin	Gallus gallus	54-61
6245995-7	1980	A significant increase in the plasma insulin/glucagon ratio, along with a significant decrease in the hepatic cyclic AMP concentration, could most likely also account for the excessive hepatic triglyceride accumulation in the PTU-treated chicks.	Propylthiouracil	226-229	insulin	Gallus gallus	37-44
222814-1	1979	Rats maintained on a high-fat diet supplemented with propylthiouracil develop a hypercholesterolemia, an increased serum level of apolipoprotein (apo) E, abnormal very low density lipoproteins (VLDL) and low density lipoproteins (LDL), and a fatty liver which contains cholesterol ester as its major lipid.	Propylthiouracil	53-69	apolipoprotein E	Rattus norvegicus	130-152
743306-0	1978	Isolation of thyroglobulin messenger RNA from rats: increased yield in propylthiouracil-induced hyperplasia.	Propylthiouracil	71-87	thyroglobulin	Rattus norvegicus	13-26
109291-0	1978	Effect of active and passive immunization with TRH on plasma TSH response to propylthiouracil.	Propylthiouracil	77-93	thyrotropin releasing hormone	Rattus norvegicus	47-50
109291-2	1978	The plasma TSH response to propylthiouracil (PTU) in TRH-bovine serum albumin (BSA)-immunized rats was significantly lower than that of BSA-immunized or non-immunized rats.	Propylthiouracil	27-43	thyrotropin releasing hormone	Rattus norvegicus	53-56
109291-2	1978	The plasma TSH response to propylthiouracil (PTU) in TRH-bovine serum albumin (BSA)-immunized rats was significantly lower than that of BSA-immunized or non-immunized rats.	Propylthiouracil	45-48	thyrotropin releasing hormone	Rattus norvegicus	53-56
744122-1	1978	A reinvestigation of the mechanism of action of methylmercaptoimidazole, propylthiouracil, and thiouracil on thyroid peroxidase (TPO) was undertaken.	Propylthiouracil	73-89	thyroid peroxidase	Rattus norvegicus	129-132
744122-2	1978	A preliminary incubation of TPO and H2O2 with methylmercaptoimidazole, propylthiouracil, or thiouracil was carried out in the absence of oxidizable substrates (i.e. I- or guaiacol).	Propylthiouracil	71-87	thyroid peroxidase	Rattus norvegicus	28-31
277090-4	1978	Ad 3) Histologically, and to some extent clinically, hepatocellular (e.g. propylthiouracil) may be distinguished from cholestatic (e.g. tolbutamide) reactions, but overlapping (e.g. phenylbutazone) and individual variations are common.	Propylthiouracil	74-90	presenilin 1	Homo sapiens	0-4
926866-0	1977	Thyroxine and propylthiouracil-induced changes in the activity of monoamine oxidase in the fetal rat.	Propylthiouracil	14-30	monoamine oxidase A	Rattus norvegicus	66-83
415831-5	1978	Normal TSH response to TRH was restored by partial thyroidectomy and in some cases by propyl thiouracil administration.	Propylthiouracil	86-103	thyrotropin releasing hormone	Homo sapiens	23-26
870309-0	1977	Growth hormone, somatomedin and cartilage sulfation in failure of catch-up growth after propylthiouracil-induced hypothyroidism in the rat.	Propylthiouracil	88-104	gonadotropin releasing hormone receptor	Rattus norvegicus	0-14
880264-0	1977	Inhibition of dopamine beta-hydroxylase by anti-thyroid agents, methimazole and propylthiouracil.	Propylthiouracil	80-96	dopamine beta-hydroxylase	Homo sapiens	14-39
870309-7	1977	Bioassayable serum somatomedin (Sm) activity decreased during PTU treatment in one of two experiments but returned to a normal level by recovery day 7.	Propylthiouracil	62-65	insulin-like growth factor 1	Rattus norvegicus	19-30
870309-7	1977	Bioassayable serum somatomedin (Sm) activity decreased during PTU treatment in one of two experiments but returned to a normal level by recovery day 7.	Propylthiouracil	62-65	insulin-like growth factor 1	Rattus norvegicus	32-34
947933-1	1976	The mechanism of inhibition of human thyroid iodide peroxidase (TPO) by 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) used in the therapy of hyperthyroid patients was studied in vitro.	Propylthiouracil	72-93	thyroid peroxidase	Homo sapiens	37-62
822970-1	1976	The inactivation of synthetic [3H]thyrotrophin-releasing hormone (TRH) by plasma was studied in rats treated with propylthiouracil (PTU) alone or with PTU and thyroxine.	Propylthiouracil	114-130	thyrotropin releasing hormone	Rattus norvegicus	66-69
822970-1	1976	The inactivation of synthetic [3H]thyrotrophin-releasing hormone (TRH) by plasma was studied in rats treated with propylthiouracil (PTU) alone or with PTU and thyroxine.	Propylthiouracil	132-135	thyrotropin releasing hormone	Rattus norvegicus	66-69
184009-2	1976	Daily intubation with propylthiouracil (PTU) for 10 days in doses of 5 to 50 mg per kg significantly reduced the elevation of SGOT activity, completely suppressed the serum ornithine carbamyltransferase changes, and reduced the degree of necrosis found 24 hr after the intragastric administration of CCl4.	Propylthiouracil	22-38	C-C motif chemokine ligand 4	Rattus norvegicus	300-304
184009-2	1976	Daily intubation with propylthiouracil (PTU) for 10 days in doses of 5 to 50 mg per kg significantly reduced the elevation of SGOT activity, completely suppressed the serum ornithine carbamyltransferase changes, and reduced the degree of necrosis found 24 hr after the intragastric administration of CCl4.	Propylthiouracil	40-43	C-C motif chemokine ligand 4	Rattus norvegicus	300-304
184009-4	1976	When PTU was given in liguid diets for 6 days, protection against CCl4 was increased.	Propylthiouracil	5-8	C-C motif chemokine ligand 4	Rattus norvegicus	66-70
184009-7	1976	Thus, it has been observed that PTU affords partial protection against some end-stage consequences of CCl4 liver injury such as cell necrosis and release of intracellular enzymes.	Propylthiouracil	32-35	C-C motif chemokine ligand 4	Rattus norvegicus	102-106
819251-3	1976	In rats made hypothyroid by treatment with propylthiouracil or by thyroidectomy, basal GH and TSH levels were significantly elevated with exaggerated responses to TRH.	Propylthiouracil	43-59	gonadotropin releasing hormone receptor	Rattus norvegicus	87-89
819251-3	1976	In rats made hypothyroid by treatment with propylthiouracil or by thyroidectomy, basal GH and TSH levels were significantly elevated with exaggerated responses to TRH.	Propylthiouracil	43-59	thyrotropin releasing hormone	Rattus norvegicus	163-166
822970-1	1976	The inactivation of synthetic [3H]thyrotrophin-releasing hormone (TRH) by plasma was studied in rats treated with propylthiouracil (PTU) alone or with PTU and thyroxine.	Propylthiouracil	151-154	thyrotropin releasing hormone	Rattus norvegicus	66-69
947933-1	1976	The mechanism of inhibition of human thyroid iodide peroxidase (TPO) by 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) used in the therapy of hyperthyroid patients was studied in vitro.	Propylthiouracil	72-93	thyroid peroxidase	Homo sapiens	64-67
947933-1	1976	The mechanism of inhibition of human thyroid iodide peroxidase (TPO) by 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) used in the therapy of hyperthyroid patients was studied in vitro.	Propylthiouracil	95-98	thyroid peroxidase	Homo sapiens	37-62
947933-1	1976	The mechanism of inhibition of human thyroid iodide peroxidase (TPO) by 6-propyl-2-thiouracil (PTU) and 1-methyl-2-mercaptoimidazole (MMI) used in the therapy of hyperthyroid patients was studied in vitro.	Propylthiouracil	95-98	thyroid peroxidase	Homo sapiens	64-67
947933-6	1976	The concentrations of PTU and MMI producing 50% inhibition of TPO were 2 x 10-6m and 8 x 10-7m, respectively, 2-Mercaptoimidazole inhibited TPO reversibly but 1-methylimidazole and imidazole did not.	Propylthiouracil	22-25	thyroid peroxidase	Homo sapiens	62-65
947933-6	1976	The concentrations of PTU and MMI producing 50% inhibition of TPO were 2 x 10-6m and 8 x 10-7m, respectively, 2-Mercaptoimidazole inhibited TPO reversibly but 1-methylimidazole and imidazole did not.	Propylthiouracil	22-25	thyroid peroxidase	Homo sapiens	140-143
947933-10	1976	TPO activity in the PTU treated thyroid homogenate was significantly lower than that in the control before dialysis, but the activity was restored to the control value after dialysis.	Propylthiouracil	20-23	thyroid peroxidase	Homo sapiens	0-3
1138879-6	1975	In a second series of experiments extremely iodine-poor thyroglobulin (smaller than 0.005%) was obtained from propylthiouracil-treated rats.	Propylthiouracil	110-126	thyroglobulin	Rattus norvegicus	56-69
1248450-3	1976	Using this increase in GH of hypothyroid rats to measure the biological effectiveness of single doses of both iodothyronines, we have shown that the administration of 6-propyl-2-thiouracil (PTU) interferes with the activity of T4, but not with that of T3.	Propylthiouracil	167-188	gonadotropin releasing hormone receptor	Rattus norvegicus	23-25
1248450-3	1976	Using this increase in GH of hypothyroid rats to measure the biological effectiveness of single doses of both iodothyronines, we have shown that the administration of 6-propyl-2-thiouracil (PTU) interferes with the activity of T4, but not with that of T3.	Propylthiouracil	190-193	gonadotropin releasing hormone receptor	Rattus norvegicus	23-25
1173483-0	1975	Role of growth hormone in the enhancement of the propylthiouracil-induced goitrogenesis by small doses of thyroxine.	Propylthiouracil	49-65	gonadotropin releasing hormone receptor	Rattus norvegicus	8-22
805160-7	1975	The serum TSH response to TRH (DELTAMUU/ml  over base line) was greater during PTU therapy than during the control period.	Propylthiouracil	79-82	thyrotropin releasing hormone	Homo sapiens	26-29
809721-8	1975	In PTU (propylthiouracil)-treated rats ingesting approximately the same amount of TRH, a plasma TSH increase failed to occur.	Propylthiouracil	3-6	thyrotropin releasing hormone	Rattus norvegicus	82-85
809721-8	1975	In PTU (propylthiouracil)-treated rats ingesting approximately the same amount of TRH, a plasma TSH increase failed to occur.	Propylthiouracil	8-24	thyrotropin releasing hormone	Rattus norvegicus	82-85
805160-10	1975	The data suggest that PTU blocks extrathyroidal conversion of T4 to T3, thus increasing pituitary TSH secretion and augmenting the TSH response to TRH.	Propylthiouracil	22-25	thyrotropin releasing hormone	Homo sapiens	147-150
4955039-0	1965	[Influence of propylthiouracil on the biosynthesis of thyroglobulin and its precursors by surviving rat thyroid slices].	Propylthiouracil	14-30	thyroglobulin	Rattus norvegicus	54-67
4629908-6	1973	TRH responsiveness was restored when T(3) levels fell to normal after propylthiouracil therapy.	Propylthiouracil	70-86	thyrotropin releasing hormone	Homo sapiens	0-3
33846035-9	2021	The mechanism could be through an accumulation of PTU in neutrophils, altering the structure of MPO and making it immunogenic.	Propylthiouracil	50-53	myeloperoxidase	Homo sapiens	96-99
13162029-0	1954	[Effect of ACTH on goiter produced by propylthiouracil].	Propylthiouracil	38-54	proopiomelanocortin	Homo sapiens	11-15
33462684-0	2021	Inhibition of lysyl oxidase stimulates TGF-beta signaling and metalloproteinases-2 and -9 expression and contributes to the disruption of ascending aorta in rats: protection by propylthiouracil.	Propylthiouracil	177-193	lysyl oxidase	Rattus norvegicus	14-27
33462684-0	2021	Inhibition of lysyl oxidase stimulates TGF-beta signaling and metalloproteinases-2 and -9 expression and contributes to the disruption of ascending aorta in rats: protection by propylthiouracil.	Propylthiouracil	177-193	transforming growth factor alpha	Rattus norvegicus	39-47
33462684-5	2021	In BAPN-treated animals, PTU reduced apoptosis, p-SMAD2 staining, MMP-2, and -9 expression, and markedly decreased the damage to the aortic wall.	Propylthiouracil	25-28	SMAD family member 2	Rattus norvegicus	50-55
33462684-5	2021	In BAPN-treated animals, PTU reduced apoptosis, p-SMAD2 staining, MMP-2, and -9 expression, and markedly decreased the damage to the aortic wall.	Propylthiouracil	25-28	matrix metallopeptidase 2	Rattus norvegicus	66-79
33462684-7	2021	We have also shown that PTU, a drug already in clinical use, protects against the effects of LOX inhibition.	Propylthiouracil	24-27	lysyl oxidase	Rattus norvegicus	93-96
14288514-0	1965	PROPYLTHIOURACIL MODIFIES THE URINARY EFFECTS OF GROWTH HORMONE AND OF ALDOSTERONE IN RATS.	Propylthiouracil	0-16	gonadotropin releasing hormone receptor	Rattus norvegicus	49-63
13936579-0	1962	In vivo effect of propylthiouracil on glucose C-14 oxidation in rat thyroid tissue.	Propylthiouracil	18-34	anti-Mullerian hormone receptor type 2	Rattus norvegicus	46-50
34047416-0	2021	Syringic acid, a novel thyroid hormone receptor-beta agonist, ameliorates propylthiouracil-induced thyroid toxicity in rats.	Propylthiouracil	74-90	thyroid hormone receptor beta	Rattus norvegicus	23-52
33150595-8	2021	Among the genes showing sustained downregulation, Creb, Arc, and Hes5 were concurrently downregulated by PTU, suggesting an association with neuronal mismigration, suppressed synaptic plasticity, and reduction in neural stem and progenitor cells.	Propylthiouracil	105-108	cAMP responsive element binding protein 1	Rattus norvegicus	50-54
33660355-0	2022	Supplement therapy with apelin for improving the TSH level and lipid disorders in PTU-induced hypothyroid rats.	Propylthiouracil	82-85	apelin	Rattus norvegicus	24-30
33660355-9	2022	co-administration of Apelin with T4 may offer valuable therapeutic benefits, specifically lowering blood plasma TSH, and lipid disorder and atherosclerosis biomarkers, in PTU-induced hypothyroid rats.	Propylthiouracil	171-174	apelin	Rattus norvegicus	21-27
31900035-10	2020	Incubation with 6-n-propylthiouracil induced an inhibition of lipid accumulation rate together with an increase in TAS2R38 and a decrease in genes involved in adipocyte differentiation.	Propylthiouracil	16-36	taste 2 receptor member 38	Homo sapiens	115-122
32964253-3	2020	Through optimization of the SERS conditions, including the volume of SA-protected AgNPs solution, pH of Britton-Robinson (BR) buffer solution and concentration of NaCl solution, linear responses were obtained for PTU and MTZ in the concentration ranges of 3.02 x 10-9-1.06 x 10-5 mol L-1 and 1.21 x 10-9-1.21 x 10-5 mol L-1, respectively.	Propylthiouracil	213-216	L1 cell adhesion molecule	Homo sapiens	284-293
32964253-4	2020	By the present method, the limits of detection (LODs) for the determination of PTU and MTZ were as low as 1.58 x 10-10 mol L-1 and 2.97 x 10-11 mol L-1.	Propylthiouracil	79-82	L1 cell adhesion molecule	Homo sapiens	123-132
33150595-8	2021	Among the genes showing sustained downregulation, Creb, Arc, and Hes5 were concurrently downregulated by PTU, suggesting an association with neuronal mismigration, suppressed synaptic plasticity, and reduction in neural stem and progenitor cells.	Propylthiouracil	105-108	nucleolar protein 3	Rattus norvegicus	56-59
33150595-8	2021	Among the genes showing sustained downregulation, Creb, Arc, and Hes5 were concurrently downregulated by PTU, suggesting an association with neuronal mismigration, suppressed synaptic plasticity, and reduction in neural stem and progenitor cells.	Propylthiouracil	105-108	hes family bHLH transcription factor 5	Rattus norvegicus	65-69
33150595-9	2021	Epha7 and Pvalb were also concurrently downregulated by PTU, suggesting an association with the reduction in late-stage progenitor cells.	Propylthiouracil	56-59	Eph receptor A7	Rattus norvegicus	0-5
33150595-9	2021	Epha7 and Pvalb were also concurrently downregulated by PTU, suggesting an association with the reduction in late-stage progenitor cells.	Propylthiouracil	56-59	parvalbumin	Rattus norvegicus	10-15
32703233-2	2020	Propylthiouracil (PTU) has been associated with drug-induced ANCA-associated vasculitis (AAV), with antibodies against myeloperoxidase (MPO) and proteinase 3 (PR3) present individually and together having been recognised.	Propylthiouracil	0-16	proteinase 3	Homo sapiens	145-157
32335798-0	2020	Comparative distribution of somatostatin and somatostatin receptors in PTU-induced hypothyroidism.	Propylthiouracil	71-74	somatostatin	Rattus norvegicus	28-40
32335798-8	2020	SST and SSTR subtypes like immunoreactivity increased significantly in follicular and parafollicular epithelial cells in the thyroid of PTU-treated rats.	Propylthiouracil	136-139	somatostatin	Rattus norvegicus	0-3
32335798-8	2020	SST and SSTR subtypes like immunoreactivity increased significantly in follicular and parafollicular epithelial cells in the thyroid of PTU-treated rats.	Propylthiouracil	136-139	somatostatin receptor 3	Rattus norvegicus	8-12
32335798-9	2020	The PTU-induced changes in the expression of SST and SSTR subtypes were suppressed by the administration of the LVT.	Propylthiouracil	4-7	somatostatin	Rattus norvegicus	45-48
32335798-9	2020	The PTU-induced changes in the expression of SST and SSTR subtypes were suppressed by the administration of the LVT.	Propylthiouracil	4-7	somatostatin receptor 3	Rattus norvegicus	53-57
32703233-0	2020	An unusual presentation of propylthiouracil-induced anti-MPO and PR3 positive ANCA vasculitis with associated anti-GBM antibodies, IgA nephropathy and an IgG4 interstitial infiltrate: a case report.	Propylthiouracil	27-43	myeloperoxidase	Homo sapiens	57-60
32703233-0	2020	An unusual presentation of propylthiouracil-induced anti-MPO and PR3 positive ANCA vasculitis with associated anti-GBM antibodies, IgA nephropathy and an IgG4 interstitial infiltrate: a case report.	Propylthiouracil	27-43	proteinase 3	Homo sapiens	65-68
32930947-14	2020	PTU lowered BDNF and thiol content and superoxide dismutase (SOD) and catalase (CAT) activities in the brain but increased malondialdehyde (MDA) and nitric oxide (NO) metabolites.	Propylthiouracil	0-3	brain-derived neurotrophic factor	Rattus norvegicus	12-16
32930947-14	2020	PTU lowered BDNF and thiol content and superoxide dismutase (SOD) and catalase (CAT) activities in the brain but increased malondialdehyde (MDA) and nitric oxide (NO) metabolites.	Propylthiouracil	0-3	catalase	Rattus norvegicus	80-83
32703233-2	2020	Propylthiouracil (PTU) has been associated with drug-induced ANCA-associated vasculitis (AAV), with antibodies against myeloperoxidase (MPO) and proteinase 3 (PR3) present individually and together having been recognised.	Propylthiouracil	0-16	myeloperoxidase	Homo sapiens	119-134
32703233-2	2020	Propylthiouracil (PTU) has been associated with drug-induced ANCA-associated vasculitis (AAV), with antibodies against myeloperoxidase (MPO) and proteinase 3 (PR3) present individually and together having been recognised.	Propylthiouracil	0-16	proteinase 3	Homo sapiens	159-162
32703233-2	2020	Propylthiouracil (PTU) has been associated with drug-induced ANCA-associated vasculitis (AAV), with antibodies against myeloperoxidase (MPO) and proteinase 3 (PR3) present individually and together having been recognised.	Propylthiouracil	0-16	myeloperoxidase	Homo sapiens	136-139
32703233-2	2020	Propylthiouracil (PTU) has been associated with drug-induced ANCA-associated vasculitis (AAV), with antibodies against myeloperoxidase (MPO) and proteinase 3 (PR3) present individually and together having been recognised.	Propylthiouracil	18-21	myeloperoxidase	Homo sapiens	119-134
32703233-2	2020	Propylthiouracil (PTU) has been associated with drug-induced ANCA-associated vasculitis (AAV), with antibodies against myeloperoxidase (MPO) and proteinase 3 (PR3) present individually and together having been recognised.	Propylthiouracil	18-21	myeloperoxidase	Homo sapiens	136-139
32703233-2	2020	Propylthiouracil (PTU) has been associated with drug-induced ANCA-associated vasculitis (AAV), with antibodies against myeloperoxidase (MPO) and proteinase 3 (PR3) present individually and together having been recognised.	Propylthiouracil	18-21	proteinase 3	Homo sapiens	145-157
32703233-2	2020	Propylthiouracil (PTU) has been associated with drug-induced ANCA-associated vasculitis (AAV), with antibodies against myeloperoxidase (MPO) and proteinase 3 (PR3) present individually and together having been recognised.	Propylthiouracil	18-21	proteinase 3	Homo sapiens	159-162
32703233-4	2020	We present a case of PTU-induced anti-MPO and PR3 positive ANCA vasculitis with associated anti-GBM antibodies, IgA nephropathy and an IgG4 interstitial infiltrate.	Propylthiouracil	21-24	myeloperoxidase	Homo sapiens	38-41
32703233-4	2020	We present a case of PTU-induced anti-MPO and PR3 positive ANCA vasculitis with associated anti-GBM antibodies, IgA nephropathy and an IgG4 interstitial infiltrate.	Propylthiouracil	21-24	proteinase 3	Homo sapiens	46-49
31508180-1	2019	Objective: The aim of the present study is to evaluate the effects of methimazole (MTZ) and propylthiouracil (PTU) treatments on osteopontin (OPN) and oxidative stress in Graves" disease (GD).	Propylthiouracil	92-108	secreted phosphoprotein 1	Homo sapiens	129-140
32579134-10	2020	All treatments attenuated significantly the propylthiouracil-elevated TSH, homocysteine, creatinine, uric acid, glucose-6-phosphatase, insulin, and malondialdehyde levels, and restored favorably the propylthiouracil-altered lipid profile, T3, T4, and endogenous antioxidant levels.	Propylthiouracil	44-60	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	112-133
31691303-11	2020	CONCLUSIONS: NaF and NaOCl solutions were able to electrochemically dissolve PTU F1 and WOGS instruments.	Propylthiouracil	77-80	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
31463706-8	2020	NOS1 protein content was increased in both PTU and L-thyroxine treatments.	Propylthiouracil	43-46	nitric oxide synthase 1	Rattus norvegicus	0-4
31697382-6	2020	Thyroperoxidase activity was determined in thyroid gland microsomes treated with PTU or MMI in vitro and ex vivo from thyroid gland microsomes prepared from exposed animals.	Propylthiouracil	81-84	thyroid peroxidase	Rattus norvegicus	0-15
31215278-10	2019	Administration of PTU attenuated thiol and superoxide dismutase (SOD), and catalase (CAT) activities in the brain tissues, whereas increased malondialdehyde (MDA) and nitric oxide (NO) metabolites.	Propylthiouracil	18-21	catalase	Rattus norvegicus	75-83
31215278-10	2019	Administration of PTU attenuated thiol and superoxide dismutase (SOD), and catalase (CAT) activities in the brain tissues, whereas increased malondialdehyde (MDA) and nitric oxide (NO) metabolites.	Propylthiouracil	18-21	catalase	Rattus norvegicus	85-88
31353729-2	2019	Rats were challenged with PTU, resulting in, increased thyroid gland weight, decreased liver weight and antioxidant activities, reduced serum tri-iodothyronine and thyroxine levels with increased thyroid stimulating hormone levels, and elevated serum aspartate aminotransferase level.	Propylthiouracil	26-29	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	251-277
30610492-3	2019	Methimazole (MMI) and propylthiouracil (PTU) therapies inhibit thyroid hormone synthesis blocking the activity of deiodinase and TPO enzymes.	Propylthiouracil	22-38	thyroid peroxidase	Homo sapiens	129-132
30610492-3	2019	Methimazole (MMI) and propylthiouracil (PTU) therapies inhibit thyroid hormone synthesis blocking the activity of deiodinase and TPO enzymes.	Propylthiouracil	40-43	thyroid peroxidase	Homo sapiens	129-132
32242301-11	2020	Further, a down regulation in the TSHR expression in thyroid was observed in AVMF or PTU treated groups.	Propylthiouracil	85-88	thyroid stimulating hormone receptor	Rattus norvegicus	34-38
32027661-3	2020	Anti-thyroid drugs methimazole and propylthiouracil have been associated with drug induced agranulocytosis (severe lower white blood cell count) in patients with B*27:05, B*38:02 and DRB1*08:03 alleles in different populations: Taiwanese, Vietnamese, Han Chinese and Caucasian.	Propylthiouracil	35-51	major histocompatibility complex, class II, DR beta 1	Homo sapiens	183-187
30789800-6	2020	All doses of Vit C increased thyroxine, protein and albumin and thiol content in in renal and liver tissues while, decreased AST, ALT and ALK-P concentration and MDA in liver and renal tissues compared to PTU group (P<0.05-P<0.001).	Propylthiouracil	205-208	vitrin	Rattus norvegicus	13-16
31922012-4	2019	In human TAS2R38 genes located on the chromosome number 7 and consist of different nucleotide polymorphism that related to detection of the phenotype of different chemical compounds such as 6-n-propylthiouracil (PROP) and phenylthiocarbamide bitterness and this Gene is the member of the TAS2R genes which are eleven pseudogenes and twenty that has roles in many biological processes.	Propylthiouracil	190-210	taste 2 receptor member 38	Homo sapiens	9-16
31922012-4	2019	In human TAS2R38 genes located on the chromosome number 7 and consist of different nucleotide polymorphism that related to detection of the phenotype of different chemical compounds such as 6-n-propylthiouracil (PROP) and phenylthiocarbamide bitterness and this Gene is the member of the TAS2R genes which are eleven pseudogenes and twenty that has roles in many biological processes.	Propylthiouracil	212-216	taste 2 receptor member 38	Homo sapiens	9-16
31289700-5	2019	The downstream target gene Pvalb was significantly downregulated in brains from young rats after in utero exposure to propylthiouracil (PTU), a medicinal drug inhibiting TH synthesis.	Propylthiouracil	118-134	parvalbumin	Rattus norvegicus	27-32
31289700-5	2019	The downstream target gene Pvalb was significantly downregulated in brains from young rats after in utero exposure to propylthiouracil (PTU), a medicinal drug inhibiting TH synthesis.	Propylthiouracil	136-139	parvalbumin	Rattus norvegicus	27-32
31005965-11	2019	In the GWASs, the highest associations were for bitter taste (rs1726866-TAS2R38, with P = 7.74 x 10-18 for phenylthiocarbamide and P = 3.96 x 10-19 for 6-n-propylthiouracil).	Propylthiouracil	152-172	taste 2 receptor member 38	Homo sapiens	72-79
31508180-1	2019	Objective: The aim of the present study is to evaluate the effects of methimazole (MTZ) and propylthiouracil (PTU) treatments on osteopontin (OPN) and oxidative stress in Graves" disease (GD).	Propylthiouracil	92-108	secreted phosphoprotein 1	Homo sapiens	142-145
31508180-1	2019	Objective: The aim of the present study is to evaluate the effects of methimazole (MTZ) and propylthiouracil (PTU) treatments on osteopontin (OPN) and oxidative stress in Graves" disease (GD).	Propylthiouracil	110-113	secreted phosphoprotein 1	Homo sapiens	129-140
31508180-1	2019	Objective: The aim of the present study is to evaluate the effects of methimazole (MTZ) and propylthiouracil (PTU) treatments on osteopontin (OPN) and oxidative stress in Graves" disease (GD).	Propylthiouracil	110-113	secreted phosphoprotein 1	Homo sapiens	142-145
31508180-9	2019	OPN level significantly decreased in the GD group taking PTU treatment; however OPN levels in the group taking MTZ treatment did not change significantly when compared to the pretreatment value.	Propylthiouracil	57-60	secreted phosphoprotein 1	Homo sapiens	0-3
31508180-10	2019	Conclusion: PTU treatment is more effective in decreasing OPN and oxidative stress in GD patients, when compared to the MTZ treatment.	Propylthiouracil	12-15	secreted phosphoprotein 1	Homo sapiens	58-61
30523115-4	2019	In the present study, to assess how RLC phosphorylation influences length-dependent myosin function as myosin motor speed varies, we used a propylthiouracil (PTU) diet to induce &gt;95% expression of the slower beta-myosin heavy chain isoform in rat cardiac ventricles.	Propylthiouracil	140-156	myosin heavy chain 7	Rattus norvegicus	211-234
30769017-5	2019	Further, cardiac-specific overexpression of Med13 in mice that were treated with propylthiouracil (PTU), an inhibitor of the biosynthesis of the active TH, triiodothyronine (T3), resulted in resistance to PTU-dependent decreases in cardiac contractility.	Propylthiouracil	81-97	mediator complex subunit 13	Mus musculus	44-49
30769017-5	2019	Further, cardiac-specific overexpression of Med13 in mice that were treated with propylthiouracil (PTU), an inhibitor of the biosynthesis of the active TH, triiodothyronine (T3), resulted in resistance to PTU-dependent decreases in cardiac contractility.	Propylthiouracil	99-102	mediator complex subunit 13	Mus musculus	44-49
30769017-5	2019	Further, cardiac-specific overexpression of Med13 in mice that were treated with propylthiouracil (PTU), an inhibitor of the biosynthesis of the active TH, triiodothyronine (T3), resulted in resistance to PTU-dependent decreases in cardiac contractility.	Propylthiouracil	205-208	mediator complex subunit 13	Mus musculus	44-49
30906468-5	2019	Furthermore, the specific knockdown of connexin-32 (Cx32; a major GJ component protein in hepatocytes) using small interfering RNA was observed to decrease necrosis, intracellular PTU content and the level of reactive oxygen species (ROS) following PTU exposure.	Propylthiouracil	180-183	gap junction protein, beta 1	Rattus norvegicus	39-50
30906468-5	2019	Furthermore, the specific knockdown of connexin-32 (Cx32; a major GJ component protein in hepatocytes) using small interfering RNA was observed to decrease necrosis, intracellular PTU content and the level of reactive oxygen species (ROS) following PTU exposure.	Propylthiouracil	180-183	gap junction protein, beta 1	Rattus norvegicus	52-56
30906468-5	2019	Furthermore, the specific knockdown of connexin-32 (Cx32; a major GJ component protein in hepatocytes) using small interfering RNA was observed to decrease necrosis, intracellular PTU content and the level of reactive oxygen species (ROS) following PTU exposure.	Propylthiouracil	249-252	gap junction protein, beta 1	Rattus norvegicus	39-50
30906468-5	2019	Furthermore, the specific knockdown of connexin-32 (Cx32; a major GJ component protein in hepatocytes) using small interfering RNA was observed to decrease necrosis, intracellular PTU content and the level of reactive oxygen species (ROS) following PTU exposure.	Propylthiouracil	249-252	gap junction protein, beta 1	Rattus norvegicus	52-56
30906468-6	2019	These observations demonstrated that suppressing GJ Cx32 could confer protection against PTU-induced cytotoxicity through decreasing the accumulation of PTU and ROS.	Propylthiouracil	89-92	gap junction protein, beta 1	Rattus norvegicus	52-56
30906468-6	2019	These observations demonstrated that suppressing GJ Cx32 could confer protection against PTU-induced cytotoxicity through decreasing the accumulation of PTU and ROS.	Propylthiouracil	153-156	gap junction protein, beta 1	Rattus norvegicus	52-56
31027105-2	2019	An experimental animal study recently demonstrated that disordered NETs induced by propylthiouracil (PTU) could contribute to the production of MPO anti-neutrophil cytoplasmic antibody (ANCA) and the development of ANCA-associated vasculitis (AAV).	Propylthiouracil	83-99	myeloperoxidase	Homo sapiens	144-147
31027105-2	2019	An experimental animal study recently demonstrated that disordered NETs induced by propylthiouracil (PTU) could contribute to the production of MPO anti-neutrophil cytoplasmic antibody (ANCA) and the development of ANCA-associated vasculitis (AAV).	Propylthiouracil	101-104	myeloperoxidase	Homo sapiens	144-147
30448381-7	2019	Morpholino knockdown of TH transporter mct8 and treatment with 6-propyl-2-thiouracil (PTU) was used to reduce cellular uptake and production of TH, an effect that was associated with downregulation of dio3-b at 120 hpf.	Propylthiouracil	63-84	iodothyronine deiodinase 3b	Danio rerio	201-207
30448381-7	2019	Morpholino knockdown of TH transporter mct8 and treatment with 6-propyl-2-thiouracil (PTU) was used to reduce cellular uptake and production of TH, an effect that was associated with downregulation of dio3-b at 120 hpf.	Propylthiouracil	86-89	iodothyronine deiodinase 3b	Danio rerio	201-207
30367912-3	2019	In the present study, we report that PTU administration to rat induces hepatic epigenetic changes by upregulating expression of DNMT1, DNMT3a, DNMT3b, MBD4, MeCP2, p53 and Gadd45a and down-regulation of PCNA and C/EBP-beta.	Propylthiouracil	37-40	DNA methyltransferase 1	Rattus norvegicus	128-133
30367912-3	2019	In the present study, we report that PTU administration to rat induces hepatic epigenetic changes by upregulating expression of DNMT1, DNMT3a, DNMT3b, MBD4, MeCP2, p53 and Gadd45a and down-regulation of PCNA and C/EBP-beta.	Propylthiouracil	37-40	DNA methyltransferase 3 alpha	Rattus norvegicus	135-141
30367912-3	2019	In the present study, we report that PTU administration to rat induces hepatic epigenetic changes by upregulating expression of DNMT1, DNMT3a, DNMT3b, MBD4, MeCP2, p53 and Gadd45a and down-regulation of PCNA and C/EBP-beta.	Propylthiouracil	37-40	DNA methyltransferase 3 beta	Rattus norvegicus	143-149
30367912-3	2019	In the present study, we report that PTU administration to rat induces hepatic epigenetic changes by upregulating expression of DNMT1, DNMT3a, DNMT3b, MBD4, MeCP2, p53 and Gadd45a and down-regulation of PCNA and C/EBP-beta.	Propylthiouracil	37-40	methyl-CpG binding domain 4 DNA glycosylase	Rattus norvegicus	151-155
30367912-3	2019	In the present study, we report that PTU administration to rat induces hepatic epigenetic changes by upregulating expression of DNMT1, DNMT3a, DNMT3b, MBD4, MeCP2, p53 and Gadd45a and down-regulation of PCNA and C/EBP-beta.	Propylthiouracil	37-40	methyl CpG binding protein 2	Rattus norvegicus	157-162
30367912-3	2019	In the present study, we report that PTU administration to rat induces hepatic epigenetic changes by upregulating expression of DNMT1, DNMT3a, DNMT3b, MBD4, MeCP2, p53 and Gadd45a and down-regulation of PCNA and C/EBP-beta.	Propylthiouracil	37-40	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	164-167
30367912-3	2019	In the present study, we report that PTU administration to rat induces hepatic epigenetic changes by upregulating expression of DNMT1, DNMT3a, DNMT3b, MBD4, MeCP2, p53 and Gadd45a and down-regulation of PCNA and C/EBP-beta.	Propylthiouracil	37-40	growth arrest and DNA-damage-inducible, alpha	Rattus norvegicus	172-179
30367912-3	2019	In the present study, we report that PTU administration to rat induces hepatic epigenetic changes by upregulating expression of DNMT1, DNMT3a, DNMT3b, MBD4, MeCP2, p53 and Gadd45a and down-regulation of PCNA and C/EBP-beta.	Propylthiouracil	37-40	proliferating cell nuclear antigen	Rattus norvegicus	203-207
30367912-3	2019	In the present study, we report that PTU administration to rat induces hepatic epigenetic changes by upregulating expression of DNMT1, DNMT3a, DNMT3b, MBD4, MeCP2, p53 and Gadd45a and down-regulation of PCNA and C/EBP-beta.	Propylthiouracil	37-40	CCAAT/enhancer binding protein beta	Rattus norvegicus	212-222
30367912-5	2019	On the other hand, co-administration of curcumin, a polyphenol extract from the rhizome of Curcuma longa L, along with PTU ameliorates PTU- induced oxidative stress and epigenetic parameters except for the expression of MBD4.	Propylthiouracil	119-122	methyl-CpG binding domain 4 DNA glycosylase	Rattus norvegicus	220-224
30367912-5	2019	On the other hand, co-administration of curcumin, a polyphenol extract from the rhizome of Curcuma longa L, along with PTU ameliorates PTU- induced oxidative stress and epigenetic parameters except for the expression of MBD4.	Propylthiouracil	135-138	methyl-CpG binding domain 4 DNA glycosylase	Rattus norvegicus	220-224
30413058-3	2018	The previously solved X-ray crystal structure of the PTU bound to mammalian lactoperoxidase (LPO) reveals that the LPO-PTU binding site is basically a hydrophobic channel.	Propylthiouracil	53-56	lactoperoxidase	Homo sapiens	93-96
30413058-3	2018	The previously solved X-ray crystal structure of the PTU bound to mammalian lactoperoxidase (LPO) reveals that the LPO-PTU binding site is basically a hydrophobic channel.	Propylthiouracil	53-56	lactoperoxidase	Homo sapiens	115-118
30413058-3	2018	The previously solved X-ray crystal structure of the PTU bound to mammalian lactoperoxidase (LPO) reveals that the LPO-PTU binding site is basically a hydrophobic channel.	Propylthiouracil	119-122	lactoperoxidase	Homo sapiens	93-96
30413058-3	2018	The previously solved X-ray crystal structure of the PTU bound to mammalian lactoperoxidase (LPO) reveals that the LPO-PTU binding site is basically a hydrophobic channel.	Propylthiouracil	119-122	lactoperoxidase	Homo sapiens	115-118
29234621-0	2017	Neonatal Exposure to 6-n-Propyl-Thiouracil, an Anti-Thyroid Drug, Alters Expression of Hepatic DNA Methyltransferases, Methyl CpG-Binding Proteins, Gadd45a, p53, and PCNA in Adult Male Rats.	Propylthiouracil	21-42	growth arrest and DNA-damage-inducible, alpha	Rattus norvegicus	148-155
29896255-0	2018	Therapeutic effects of acupuncture with MOK, a polyherbal medicine, on PTU-induced hypothyroidism in rats.	Propylthiouracil	71-74	MOK protein kinase	Rattus norvegicus	40-43
29896255-4	2018	MOK was administered by acupuncture on the acupoints around the thyroid gland of PTU-induced hypothyroidism rats once daily for 2 weeks following hypothyroidism induction.	Propylthiouracil	81-84	MOK protein kinase	Rattus norvegicus	0-3
29896255-5	2018	Administration of MOK pharmacopuncture significantly increased the PTU-induced decrease in body temperature of hypothyroidism rats.	Propylthiouracil	67-70	MOK protein kinase	Rattus norvegicus	18-21
30137252-1	2018	TAS2R38 gene variants, which confer sensitivity to specific bitter tastants (e.g., 6-n-propylthiouracil), have been repeatedly associated with lower alcohol use via greater bitterness perception, but research exploring TAS2R38 variation in relation to smoking shows mixed results.	Propylthiouracil	83-103	taste 2 receptor member 38	Homo sapiens	0-7
30137252-8	2018	As expected, there was a relationship between TAS2R38 diplotype and 6-n-propylthiouracil bitterness.	Propylthiouracil	68-88	taste 2 receptor member 38	Homo sapiens	46-53
29888703-0	2018	PR3-ANCA: a potential biomarker of disease activity for propylthiouracil-induced ANCA-associated vasculitis.	Propylthiouracil	56-72	proteinase 3	Homo sapiens	0-3
29290043-10	2018	PTU administration attenuated thiol and BDNF content as well as the activities of superoxide dismutase (SOD) and catalase (CAT) in the brain tissues while increased molondialdehyde (MDA).	Propylthiouracil	0-3	brain-derived neurotrophic factor	Rattus norvegicus	40-44
29290043-10	2018	PTU administration attenuated thiol and BDNF content as well as the activities of superoxide dismutase (SOD) and catalase (CAT) in the brain tissues while increased molondialdehyde (MDA).	Propylthiouracil	0-3	catalase	Rattus norvegicus	113-121
29688449-4	2018	CD-1 mice could readily use vapor cues from quinine hydrochloride, denatonium benzoate (DB), and 6-propyl-2-thiouracil to avoid their taste.	Propylthiouracil	97-118	CD1 antigen complex	Mus musculus	0-4
29228274-5	2018	An initial set of 18 chemicals was used to establish the assay, along with the known DIO1 inhibitor 6-propylthiouracil as a positive control.	Propylthiouracil	100-118	iodothyronine deiodinase 1	Homo sapiens	85-89
29364392-5	2018	The PTU also increased malondialdehyde and nitric oxide metabolites in the brain while reduced the thiol content and superoxide dismutase and catalase activities and serum T4 level.	Propylthiouracil	4-7	catalase	Rattus norvegicus	142-150
27406012-10	2017	After acute stress induction, increased MPO and MDA levels in heart and elevated MPO activity in liver were inhibited in PTU-treated HIE group.	Propylthiouracil	121-124	myeloperoxidase	Rattus norvegicus	40-43
27406012-10	2017	After acute stress induction, increased MPO and MDA levels in heart and elevated MPO activity in liver were inhibited in PTU-treated HIE group.	Propylthiouracil	121-124	myeloperoxidase	Rattus norvegicus	81-84
27406012-11	2017	In MIE rats, increased MPO and declined GSH levels of the gastric tissue and small intestine, and elevated MDA levels of gastric tissue were reversed in PTU-treated MIE group.	Propylthiouracil	153-156	myeloperoxidase	Rattus norvegicus	23-26
29234621-0	2017	Neonatal Exposure to 6-n-Propyl-Thiouracil, an Anti-Thyroid Drug, Alters Expression of Hepatic DNA Methyltransferases, Methyl CpG-Binding Proteins, Gadd45a, p53, and PCNA in Adult Male Rats.	Propylthiouracil	21-42	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	157-160
29234621-0	2017	Neonatal Exposure to 6-n-Propyl-Thiouracil, an Anti-Thyroid Drug, Alters Expression of Hepatic DNA Methyltransferases, Methyl CpG-Binding Proteins, Gadd45a, p53, and PCNA in Adult Male Rats.	Propylthiouracil	21-42	proliferating cell nuclear antigen	Rattus norvegicus	166-170
29234621-3	2017	Objectives: The objectives of the study were to investigate the effects of neonatal exposure of PTU on the expression of DNA methyltransferases (DNMTs), methyl-DNA binding proteins (MBDs), Gadd45a, p53, and proliferating cell nuclear antigen (PCNA) in adult rat liver.	Propylthiouracil	96-99	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	198-201
29234621-3	2017	Objectives: The objectives of the study were to investigate the effects of neonatal exposure of PTU on the expression of DNA methyltransferases (DNMTs), methyl-DNA binding proteins (MBDs), Gadd45a, p53, and proliferating cell nuclear antigen (PCNA) in adult rat liver.	Propylthiouracil	96-99	proliferating cell nuclear antigen	Rattus norvegicus	207-241
29234621-3	2017	Objectives: The objectives of the study were to investigate the effects of neonatal exposure of PTU on the expression of DNA methyltransferases (DNMTs), methyl-DNA binding proteins (MBDs), Gadd45a, p53, and proliferating cell nuclear antigen (PCNA) in adult rat liver.	Propylthiouracil	96-99	proliferating cell nuclear antigen	Rattus norvegicus	243-247
29234621-5	2017	Results: Persistent exposure to PTU from birth caused significant downregulation of expression of DNMT1 and DNMT3a and upregulation of DNMT3b, MBD4, and Gadd45a without any damage to DNA.	Propylthiouracil	32-35	DNA methyltransferase 1	Rattus norvegicus	98-103
29234621-5	2017	Results: Persistent exposure to PTU from birth caused significant downregulation of expression of DNMT1 and DNMT3a and upregulation of DNMT3b, MBD4, and Gadd45a without any damage to DNA.	Propylthiouracil	32-35	DNA methyltransferase 3 alpha	Rattus norvegicus	108-114
29234621-5	2017	Results: Persistent exposure to PTU from birth caused significant downregulation of expression of DNMT1 and DNMT3a and upregulation of DNMT3b, MBD4, and Gadd45a without any damage to DNA.	Propylthiouracil	32-35	DNA methyltransferase 3 beta	Rattus norvegicus	135-141
29234621-5	2017	Results: Persistent exposure to PTU from birth caused significant downregulation of expression of DNMT1 and DNMT3a and upregulation of DNMT3b, MBD4, and Gadd45a without any damage to DNA.	Propylthiouracil	32-35	methyl-CpG binding domain 4 DNA glycosylase	Rattus norvegicus	143-147
29234621-5	2017	Results: Persistent exposure to PTU from birth caused significant downregulation of expression of DNMT1 and DNMT3a and upregulation of DNMT3b, MBD4, and Gadd45a without any damage to DNA.	Propylthiouracil	32-35	growth arrest and DNA-damage-inducible, alpha	Rattus norvegicus	153-160
29234621-6	2017	Although MeCp2 transcripts were significantly low in the liver of adult rats after persistent exposure to PTU compared to controls, its translated products were significantly higher than in controls.	Propylthiouracil	106-109	methyl CpG binding protein 2	Rattus norvegicus	9-14
29234621-7	2017	The expression of p53 and PCNA in PTU-treated rats was significantly higher and lower, respectively, than that in control rats.	Propylthiouracil	34-37	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	18-21
29234621-7	2017	The expression of p53 and PCNA in PTU-treated rats was significantly higher and lower, respectively, than that in control rats.	Propylthiouracil	34-37	proliferating cell nuclear antigen	Rattus norvegicus	26-30
28471544-7	2017	Hypothyroidism induced by 6-propyl-2-thiouracil (PTU) markedly decreased testicular glucose level with considerable reduction in expression level of GLUT3 and GLUT8.	Propylthiouracil	26-47	solute carrier family 2 (facilitated glucose transporter), member 3	Mus musculus	149-154
29181135-0	2017	Graves" Disease Thyrotoxicosis and Propylthiouracil Related Agranulocytosis Successfully Treated with Therapeutic Plasma Exchange and G-CSF Followed by Total Thyroidectomy.	Propylthiouracil	35-51	colony stimulating factor 3	Homo sapiens	134-139
28652185-1	2017	Polymorphisms in bitter taste receptor gene TAS2R38 alter the ability to sense the intensity of bitterness of phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).	Propylthiouracil	140-160	taste 2 receptor member 38	Homo sapiens	44-51
28652185-1	2017	Polymorphisms in bitter taste receptor gene TAS2R38 alter the ability to sense the intensity of bitterness of phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).	Propylthiouracil	162-166	taste 2 receptor member 38	Homo sapiens	44-51
28471544-7	2017	Hypothyroidism induced by 6-propyl-2-thiouracil (PTU) markedly decreased testicular glucose level with considerable reduction in expression level of GLUT3 and GLUT8.	Propylthiouracil	26-47	solute carrier family 2, (facilitated glucose transporter), member 8	Mus musculus	159-164
28471544-7	2017	Hypothyroidism induced by 6-propyl-2-thiouracil (PTU) markedly decreased testicular glucose level with considerable reduction in expression level of GLUT3 and GLUT8.	Propylthiouracil	49-52	solute carrier family 2 (facilitated glucose transporter), member 3	Mus musculus	149-154
28471544-7	2017	Hypothyroidism induced by 6-propyl-2-thiouracil (PTU) markedly decreased testicular glucose level with considerable reduction in expression level of GLUT3 and GLUT8.	Propylthiouracil	49-52	solute carrier family 2, (facilitated glucose transporter), member 8	Mus musculus	159-164
28471544-9	2017	There was also a rise in germ cell apoptosis with increased expression of caspase-3 in PTU-treated mice.	Propylthiouracil	87-90	caspase 3	Mus musculus	74-83
27768856-11	2017	Propylthiouracil inhibits TA4 generation.	Propylthiouracil	0-16	trace amine associated receptor 6	Homo sapiens	26-29
28127705-3	2017	After delivery, they were randomly divided into six groups and treated: (1) Control; (2) Propylthiouracil (PTU) which 0.005% PTU in their drinking; (3-5) Propylthiouracil- Vit C groups; besides PTU, dams in these groups received 10, 100 and 500 mg/kg Vit C respectively, (6) one group as a positive control; the intact rats received an effective dose, 100 mg/kg Vit.	Propylthiouracil	154-170	vitrin	Rattus norvegicus	172-175
28127705-7	2017	PTU increased time latency and traveled distance during 5 days in MWM while, reduced the spent time in target quadrant in MWM and step-trough latency (STL) in PA. PTU decreased thiol content, superoxide dismutase (SOD) and catalase (CAT) activities in the brain while, increased molondialdehyde (MDA).	Propylthiouracil	0-3	catalase	Rattus norvegicus	223-231
28127705-7	2017	PTU increased time latency and traveled distance during 5 days in MWM while, reduced the spent time in target quadrant in MWM and step-trough latency (STL) in PA. PTU decreased thiol content, superoxide dismutase (SOD) and catalase (CAT) activities in the brain while, increased molondialdehyde (MDA).	Propylthiouracil	0-3	catalase	Rattus norvegicus	233-236
28509121-12	2017	Although there are many reports on patients developing MPO-ANCA-positive crescentic glomerulonephritis after the administration of PTU, we report on a relatively rare case in which interstitial nephritis occurred after the administration of PTU.	Propylthiouracil	131-134	myeloperoxidase	Homo sapiens	55-58
28487220-2	2017	Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.	Propylthiouracil	202-222	odorant binding protein 2A	Homo sapiens	71-77
28487220-2	2017	Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.	Propylthiouracil	224-228	odorant binding protein 2A	Homo sapiens	71-77
28291538-0	2017	[Pyoderma gangrenosum associated with anti-proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) induced by propylthiouracil].	Propylthiouracil	116-132	proteinase 3	Homo sapiens	43-55
28291538-0	2017	[Pyoderma gangrenosum associated with anti-proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) induced by propylthiouracil].	Propylthiouracil	116-132	proteinase 3	Homo sapiens	95-103
28291538-4	2017	To our knowledge, there are no clinical reports describing the association of pyoderma gangrenosum (PG) and anti-proteinase3-ANCA (PR3-ANCA) induced by PTU, with ANCA levels decreasing after antithyroid drug withdrawal.	Propylthiouracil	152-155	proteinase 3	Homo sapiens	131-134
26754589-0	2016	Propylthiouracil, Perchlorate, and Thyroid-Stimulating Hormone Modulate High Concentrations of Iodide Instigated Mitochondrial Superoxide Production in the Thyroids of Metallothionein I/II Knockout Mice.	Propylthiouracil	0-16	metallothionein 1	Mus musculus	168-185
29332900-3	2017	Because hypophysectomy may decrease the secretion of thyroid stimulated hormone (TSH), we assessed whether the regulation of brain protein synthesis was mediated by changes in the plasma concentrations of thyroid hormone and ghrelin in the 6-propyl-2-thiouracil (PTU, thyroid inhibitor)-treated or control adult rats fed ornithine.	Propylthiouracil	240-261	ghrelin and obestatin prepropeptide	Rattus norvegicus	225-232
29332900-8	2017	The results suggest that dietary ornithine likely increases the rate of brain protein synthesis in control and PTU-treated rats, and that the ornithine-induced increase in the GH concentration may stimulate mainly brain protein synthesis via ghrelin.	Propylthiouracil	111-114	ghrelin and obestatin prepropeptide	Rattus norvegicus	242-249
27663841-0	2016	Exogenous apelin changes alpha and beta myosin heavy chain mRNA expression and improves cardiac function in PTU-induced hypothyroid rats.	Propylthiouracil	108-111	apelin	Rattus norvegicus	10-16
27942960-3	2016	Sprague-Dawley rats possessing ~99% alpha-MHC were treated with propylthiouracil to result in 100% beta-MHC.	Propylthiouracil	64-80	major histocompatibility complex, class I, C	Homo sapiens	104-107
27216871-2	2016	Administration of the goitrogen propylthiouracil (PTU) reduces TH production by inhibiting thyroperoxidase (TPO), an enzyme that oxidizes iodide for the synthesis of TH.	Propylthiouracil	50-53	thyroid peroxidase	Rattus norvegicus	91-106
27216871-2	2016	Administration of the goitrogen propylthiouracil (PTU) reduces TH production by inhibiting thyroperoxidase (TPO), an enzyme that oxidizes iodide for the synthesis of TH.	Propylthiouracil	50-53	thyroid peroxidase	Rattus norvegicus	108-111
26599303-7	2016	High-resolution HLA typing confirmed that HLA-B*38:02:01 was associated with carbimazole (CMZ)/methimazole (MMI)-induced agranulocytosis (OR = 265.5; 95% CI = 27.9-2528.0; P = 2.5 x 10(-14)), but not associated with propylthiouracil (PTU).	Propylthiouracil	216-232	major histocompatibility complex, class I, B	Homo sapiens	42-47
26599303-7	2016	High-resolution HLA typing confirmed that HLA-B*38:02:01 was associated with carbimazole (CMZ)/methimazole (MMI)-induced agranulocytosis (OR = 265.5; 95% CI = 27.9-2528.0; P = 2.5 x 10(-14)), but not associated with propylthiouracil (PTU).	Propylthiouracil	234-237	major histocompatibility complex, class I, B	Homo sapiens	42-47
26892488-2	2016	Hypothyroidism was induced in young-adult rats by the administration of 6-n-propyl-2-thiouracil (PTU) in tap water for 21 days.	Propylthiouracil	72-95	nuclear RNA export factor 1	Rattus norvegicus	105-108
26892488-2	2016	Hypothyroidism was induced in young-adult rats by the administration of 6-n-propyl-2-thiouracil (PTU) in tap water for 21 days.	Propylthiouracil	97-100	nuclear RNA export factor 1	Rattus norvegicus	105-108
27138342-1	2016	The ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene.	Propylthiouracil	51-71	taste 2 receptor member 38	Homo sapiens	118-125
27138342-1	2016	The ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene.	Propylthiouracil	73-77	taste 2 receptor member 38	Homo sapiens	118-125
26754589-7	2016	CONCLUSION: We concluded that PTU, KClO4, or TSH relieved the mitochondrial oxidative stress induced by high concentrations of iodide in the thyroids of both MT-I/II KO and WT mice.	Propylthiouracil	30-33	metallothionein 1	Mus musculus	158-168
27257510-3	2016	CASE PRESENTATION: A 43-year-old woman with Graves" disease developed pulmonary vasculitis and diffuse alveolar hemorrhage (DAH) associated with ANCA against myeloperoxidase and proteinase-3 that was confirmed by computed tomography (CT) and bronchoscopy and treated with PTU.	Propylthiouracil	272-275	myeloperoxidase	Homo sapiens	158-173
26606422-4	2016	Graded exposure to propylthiouracil (PTU) during development produced dose-dependent reductions in mRNA expression of nerve growth factor (Ngf) in whole hippocampus of neonates.	Propylthiouracil	19-35	nerve growth factor	Rattus norvegicus	118-137
26606422-4	2016	Graded exposure to propylthiouracil (PTU) during development produced dose-dependent reductions in mRNA expression of nerve growth factor (Ngf) in whole hippocampus of neonates.	Propylthiouracil	37-40	nerve growth factor	Rattus norvegicus	118-137
26459835-0	2016	Neonatal Persistent Exposure to 6-Propyl-2-thiouracil, a Thyroid-Disrupting Chemical, Differentially Modulates Expression of Hepatic Catalase and C/EBP-beta in Adult Rats.	Propylthiouracil	32-53	catalase	Rattus norvegicus	133-141
26459835-0	2016	Neonatal Persistent Exposure to 6-Propyl-2-thiouracil, a Thyroid-Disrupting Chemical, Differentially Modulates Expression of Hepatic Catalase and C/EBP-beta in Adult Rats.	Propylthiouracil	32-53	CCAAT/enhancer binding protein beta	Rattus norvegicus	146-156
27257510-3	2016	CASE PRESENTATION: A 43-year-old woman with Graves" disease developed pulmonary vasculitis and diffuse alveolar hemorrhage (DAH) associated with ANCA against myeloperoxidase and proteinase-3 that was confirmed by computed tomography (CT) and bronchoscopy and treated with PTU.	Propylthiouracil	272-275	proteinase 3	Homo sapiens	178-190
26027918-3	2015	We analyzed the effect of chronic 6-propyl-2-thiouracil (PTU)-induced HypoT in the expression of nuclear receptors, co-regulators and oxytocin receptor (OTR) on lactation (L) days 2, 7 and 14.	Propylthiouracil	34-55	oxytocin receptor	Rattus norvegicus	134-151
26459835-1	2016	Persistent exposure of rats to 6-propyl-2-thiouracil (PTU) from birth resulted in decreases in plasma thyroid hormone (TH) levels and hepatic expression of catalase and CCAAT enhancer binding protein beta (C/EBP-beta).	Propylthiouracil	31-52	catalase	Rattus norvegicus	156-164
26459835-1	2016	Persistent exposure of rats to 6-propyl-2-thiouracil (PTU) from birth resulted in decreases in plasma thyroid hormone (TH) levels and hepatic expression of catalase and CCAAT enhancer binding protein beta (C/EBP-beta).	Propylthiouracil	31-52	CCAAT/enhancer binding protein beta	Rattus norvegicus	169-204
26459835-1	2016	Persistent exposure of rats to 6-propyl-2-thiouracil (PTU) from birth resulted in decreases in plasma thyroid hormone (TH) levels and hepatic expression of catalase and CCAAT enhancer binding protein beta (C/EBP-beta).	Propylthiouracil	31-52	CCAAT/enhancer binding protein beta	Rattus norvegicus	206-216
26459835-1	2016	Persistent exposure of rats to 6-propyl-2-thiouracil (PTU) from birth resulted in decreases in plasma thyroid hormone (TH) levels and hepatic expression of catalase and CCAAT enhancer binding protein beta (C/EBP-beta).	Propylthiouracil	54-57	catalase	Rattus norvegicus	156-164
26459835-1	2016	Persistent exposure of rats to 6-propyl-2-thiouracil (PTU) from birth resulted in decreases in plasma thyroid hormone (TH) levels and hepatic expression of catalase and CCAAT enhancer binding protein beta (C/EBP-beta).	Propylthiouracil	54-57	CCAAT/enhancer binding protein beta	Rattus norvegicus	169-204
26459835-1	2016	Persistent exposure of rats to 6-propyl-2-thiouracil (PTU) from birth resulted in decreases in plasma thyroid hormone (TH) levels and hepatic expression of catalase and CCAAT enhancer binding protein beta (C/EBP-beta).	Propylthiouracil	54-57	CCAAT/enhancer binding protein beta	Rattus norvegicus	206-216
26459835-3	2016	PTU withdrawal on 30 days of birth restored TH levels and C/EBP-beta to control rats in adulthood.	Propylthiouracil	0-3	CCAAT/enhancer binding protein beta	Rattus norvegicus	58-68
26459835-5	2016	The results suggest that downregulation of adult hepatic catalase gene in response to persistent neonatal PTU exposure may not solely be attributed to thyroid-disrupting properties of PTU.	Propylthiouracil	106-109	catalase	Rattus norvegicus	57-65
26459835-5	2016	The results suggest that downregulation of adult hepatic catalase gene in response to persistent neonatal PTU exposure may not solely be attributed to thyroid-disrupting properties of PTU.	Propylthiouracil	184-187	catalase	Rattus norvegicus	57-65
26459835-6	2016	It is possible that besides thyroid-disrupting behavior, PTU may impair expression of hepatic catalase by altering methylation pattern of its promoter.	Propylthiouracil	57-60	catalase	Rattus norvegicus	94-102
28116157-4	2016	PTU administration reduced thiol content, superoxide dismutase (SOD), and catalase (CAT) activities in the cerebellar tissues while increasing malondialdehyde (MDA) and nitric oxide (NO) metabolites.	Propylthiouracil	0-3	catalase	Rattus norvegicus	74-82
28116157-4	2016	PTU administration reduced thiol content, superoxide dismutase (SOD), and catalase (CAT) activities in the cerebellar tissues while increasing malondialdehyde (MDA) and nitric oxide (NO) metabolites.	Propylthiouracil	0-3	catalase	Rattus norvegicus	84-87
26552761-2	2015	Furthermore, SNPs in T2R38 influence the sensitivity to 6-n-propylthiouracil (PROP) and are associated with caries risk/protection.	Propylthiouracil	56-76	taste 2 receptor member 38	Homo sapiens	21-26
26552761-2	2015	Furthermore, SNPs in T2R38 influence the sensitivity to 6-n-propylthiouracil (PROP) and are associated with caries risk/protection.	Propylthiouracil	78-82	taste 2 receptor member 38	Homo sapiens	21-26
25832883-3	2015	AIMS: To determine whether two common haplotypes of TAS2R38 (proline-alanine-valine [PAV] and alanine-valine-isoleucine [AVI]), which have been associated, respectively, with bitter taste or a lack of bitter taste produced by propylthiouracil, are associated with preference for menthol cigarettes.	Propylthiouracil	226-242	taste 2 receptor member 38	Homo sapiens	52-59
26146959-9	2015	With PTU treatment, significant thyroid enlargement and hyperplasia occurred in both TPO-KRAS(G12D) and TPO-KRAS(WT) littermates.	Propylthiouracil	5-8	thyroid peroxidase	Mus musculus	85-88
26146959-9	2015	With PTU treatment, significant thyroid enlargement and hyperplasia occurred in both TPO-KRAS(G12D) and TPO-KRAS(WT) littermates.	Propylthiouracil	5-8	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	89-93
26146959-9	2015	With PTU treatment, significant thyroid enlargement and hyperplasia occurred in both TPO-KRAS(G12D) and TPO-KRAS(WT) littermates.	Propylthiouracil	5-8	thyroid peroxidase	Mus musculus	104-107
26146959-9	2015	With PTU treatment, significant thyroid enlargement and hyperplasia occurred in both TPO-KRAS(G12D) and TPO-KRAS(WT) littermates.	Propylthiouracil	5-8	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	108-112
26367462-3	2015	Here, we investigated the possible involvement of gamma-secretase-mediated Notch3 signaling in PTU-inhibited PAH.	Propylthiouracil	95-98	notch receptor 3	Rattus norvegicus	75-81
26367462-6	2015	Immunocyto, histochemistry, and western blot showed that PTU treatment attenuated the activation of Notch3 signaling in PASMCs from monocrotaline-treated rats, which was mediated via inhibition of gamma-secretase expression especially its presenilin enhancer 2 (Pen-2) subunit.	Propylthiouracil	57-60	notch receptor 3	Rattus norvegicus	100-106
26367462-10	2015	Propylthiouracil attenuates experimental PAH via suppression of the gamma-secretase-mediated Notch3 signaling especially its presenilin enhancer 2 (Pen-2) subunit.	Propylthiouracil	0-16	notch receptor 3	Rattus norvegicus	93-99
26633377-5	2015	We observed that methimazole, thiouracil, methylthiouracil, propylthiouracil, ambazone, and thioacetazone inhibited mushroom tyrosinase.	Propylthiouracil	60-76	tyrosinase	Mus musculus	125-135
26027918-3	2015	We analyzed the effect of chronic 6-propyl-2-thiouracil (PTU)-induced HypoT in the expression of nuclear receptors, co-regulators and oxytocin receptor (OTR) on lactation (L) days 2, 7 and 14.	Propylthiouracil	34-55	oxytocin receptor	Rattus norvegicus	153-156
26027918-3	2015	We analyzed the effect of chronic 6-propyl-2-thiouracil (PTU)-induced HypoT in the expression of nuclear receptors, co-regulators and oxytocin receptor (OTR) on lactation (L) days 2, 7 and 14.	Propylthiouracil	57-60	oxytocin receptor	Rattus norvegicus	134-151
26027918-3	2015	We analyzed the effect of chronic 6-propyl-2-thiouracil (PTU)-induced HypoT in the expression of nuclear receptors, co-regulators and oxytocin receptor (OTR) on lactation (L) days 2, 7 and 14.	Propylthiouracil	57-60	oxytocin receptor	Rattus norvegicus	153-156
26247243-4	2015	OBJECTIVE: This study aimed at evaluating the prophylactic effect of apelin on HR changes and QRS voltage that occur in propylthiouracil (PTU)-induced hypothyroid rats.	Propylthiouracil	120-136	apelin	Rattus norvegicus	69-75
26247243-4	2015	OBJECTIVE: This study aimed at evaluating the prophylactic effect of apelin on HR changes and QRS voltage that occur in propylthiouracil (PTU)-induced hypothyroid rats.	Propylthiouracil	138-141	apelin	Rattus norvegicus	69-75
26247243-9	2015	CONCLUSION: The co-administration of apelin and T4 showed a protective effect on QRS voltage and HR in PTU-induced hypothyroid rats.	Propylthiouracil	103-106	apelin	Rattus norvegicus	37-43
25847082-1	2015	The present study reports the effect of 6-n-propylthiouracil (PTU)-induced hypothyroidism on oxidative stress parameter, lipid peroxidation (LPx) and major antioxidant enzyme expressions such as superoxide dismutase (SOD: SOD1 and SOD2) and catalase (CAT) in cerebral cortex rat brain during postnatal persistent (90 days PTU treatment from birth) and transient (30 days PTU treatment from birth followed by PTU withdrawal for 60 days) hypothyroidism.	Propylthiouracil	40-60	superoxide dismutase 1	Rattus norvegicus	217-220
25962824-7	2015	In the clinics, the DIO1-specific inhibitor propylthiouracil is in use for treatment of severe hyperthyroidism.	Propylthiouracil	44-60	iodothyronine deiodinase 1	Homo sapiens	20-24
26001785-4	2015	Because of this restriction, we modeled the binding mode of propylthiouracil, a weak inhibitor of CYB5R3 (IC50 = ~275 muM), and used it as a guide to predict thiouracil-biased inhibitors from the set of commercially available compounds in the ZINC database.	Propylthiouracil	60-76	cytochrome b5 reductase 3	Rattus norvegicus	98-104
26001785-5	2015	Using this approach, we validated two new potent derivatives of propylthiouracil, ZINC05626394 (IC50 = 10.81 muM) and ZINC39395747 (IC50 = 9.14 muM), both of which inhibit CYB5R3 activity in cultured cells.	Propylthiouracil	64-80	cytochrome b5 reductase 3	Rattus norvegicus	172-178
25999325-3	2015	A well-characterized example is the variable perception of bitter compounds such as 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC), which can be accounted for at the molecular level by polymorphic variants in the specific type 2 taste receptor (TAS2R38).	Propylthiouracil	84-104	taste 2 receptor member 38	Homo sapiens	256-263
25999325-3	2015	A well-characterized example is the variable perception of bitter compounds such as 6-n-propylthiouracil (PROP) and phenylthiocarbamide (PTC), which can be accounted for at the molecular level by polymorphic variants in the specific type 2 taste receptor (TAS2R38).	Propylthiouracil	106-110	taste 2 receptor member 38	Homo sapiens	256-263
26090297-1	2015	The objective of this work was to develop a rapid screening method to identify the three single nucleotide polymorphisms (SNPs) in the TAS2R38 gene, with the aim of providing a significant contribution to studies designed to assess sensitivity to the bitter taste of 6-n-propylthiouracil (PROP).	Propylthiouracil	267-287	taste 2 receptor member 38	Homo sapiens	135-142
26090297-1	2015	The objective of this work was to develop a rapid screening method to identify the three single nucleotide polymorphisms (SNPs) in the TAS2R38 gene, with the aim of providing a significant contribution to studies designed to assess sensitivity to the bitter taste of 6-n-propylthiouracil (PROP).	Propylthiouracil	289-293	taste 2 receptor member 38	Homo sapiens	135-142
26103639-2	2015	PROP tasting is primarily controlled by polymorphisms in the TAS2R38 gene.	Propylthiouracil	0-4	taste 2 receptor member 38	Homo sapiens	61-68
25847082-1	2015	The present study reports the effect of 6-n-propylthiouracil (PTU)-induced hypothyroidism on oxidative stress parameter, lipid peroxidation (LPx) and major antioxidant enzyme expressions such as superoxide dismutase (SOD: SOD1 and SOD2) and catalase (CAT) in cerebral cortex rat brain during postnatal persistent (90 days PTU treatment from birth) and transient (30 days PTU treatment from birth followed by PTU withdrawal for 60 days) hypothyroidism.	Propylthiouracil	40-60	superoxide dismutase 1	Rattus norvegicus	222-226
25847082-1	2015	The present study reports the effect of 6-n-propylthiouracil (PTU)-induced hypothyroidism on oxidative stress parameter, lipid peroxidation (LPx) and major antioxidant enzyme expressions such as superoxide dismutase (SOD: SOD1 and SOD2) and catalase (CAT) in cerebral cortex rat brain during postnatal persistent (90 days PTU treatment from birth) and transient (30 days PTU treatment from birth followed by PTU withdrawal for 60 days) hypothyroidism.	Propylthiouracil	40-60	superoxide dismutase 2	Rattus norvegicus	231-235
25847082-1	2015	The present study reports the effect of 6-n-propylthiouracil (PTU)-induced hypothyroidism on oxidative stress parameter, lipid peroxidation (LPx) and major antioxidant enzyme expressions such as superoxide dismutase (SOD: SOD1 and SOD2) and catalase (CAT) in cerebral cortex rat brain during postnatal persistent (90 days PTU treatment from birth) and transient (30 days PTU treatment from birth followed by PTU withdrawal for 60 days) hypothyroidism.	Propylthiouracil	62-65	superoxide dismutase 1	Rattus norvegicus	217-220
25847082-1	2015	The present study reports the effect of 6-n-propylthiouracil (PTU)-induced hypothyroidism on oxidative stress parameter, lipid peroxidation (LPx) and major antioxidant enzyme expressions such as superoxide dismutase (SOD: SOD1 and SOD2) and catalase (CAT) in cerebral cortex rat brain during postnatal persistent (90 days PTU treatment from birth) and transient (30 days PTU treatment from birth followed by PTU withdrawal for 60 days) hypothyroidism.	Propylthiouracil	62-65	superoxide dismutase 1	Rattus norvegicus	222-226
25847082-1	2015	The present study reports the effect of 6-n-propylthiouracil (PTU)-induced hypothyroidism on oxidative stress parameter, lipid peroxidation (LPx) and major antioxidant enzyme expressions such as superoxide dismutase (SOD: SOD1 and SOD2) and catalase (CAT) in cerebral cortex rat brain during postnatal persistent (90 days PTU treatment from birth) and transient (30 days PTU treatment from birth followed by PTU withdrawal for 60 days) hypothyroidism.	Propylthiouracil	62-65	superoxide dismutase 2	Rattus norvegicus	231-235
24972880-4	2015	Maternal exposure to PTU in the drinking water during gestation and/or lactation resulted into changes in the activities of acetylcholinesterase and two important adenosinetriphosphatases (Na(+),K(+)- and Mg(2+)-ATPase), that seemed to take place in a CNS-region-specific manner and that were dependent upon the PTU-exposure timeframe followed.	Propylthiouracil	21-24	acetylcholinesterase	Rattus norvegicus	124-144
25499719-7	2015	At day 10, T4-treated rats presented increased VEGF and PGF gene expression, while PTU-treated rats showed increased rPlf gene expression.	Propylthiouracil	83-86	periostin	Rattus norvegicus	117-121
25499719-9	2015	At day 14, PTU-treated rats showed reduced VEGF, PGF, and rPlf gene expression.	Propylthiouracil	11-14	vascular endothelial growth factor A	Rattus norvegicus	43-47
25499719-9	2015	At day 14, PTU-treated rats showed reduced VEGF, PGF, and rPlf gene expression.	Propylthiouracil	11-14	periostin	Rattus norvegicus	58-62
25499719-10	2015	PTU-treated group showed reduced VEGF immunostaining in the placental labyrinth at 14 and 19 days of gestation but it showed increased VEGF immunostaining in the spongiotrophoblast layer at day 14.	Propylthiouracil	0-3	vascular endothelial growth factor A	Rattus norvegicus	33-37
25499719-10	2015	PTU-treated group showed reduced VEGF immunostaining in the placental labyrinth at 14 and 19 days of gestation but it showed increased VEGF immunostaining in the spongiotrophoblast layer at day 14.	Propylthiouracil	0-3	vascular endothelial growth factor A	Rattus norvegicus	135-139
25499719-11	2015	PTU-treated rats showed increased Flk-1 expression at 14 days of gestation.	Propylthiouracil	0-3	kinase insert domain receptor	Rattus norvegicus	34-39
25208313-10	2015	Renal and hepatic failures were attributed to PTU-induced c-ANCA production as other serological workup was negative.	Propylthiouracil	46-49	proteinase 3	Homo sapiens	58-64
25937486-5	2015	The unexpected double myeloperoxidase/proteinase 3-ANCA positivity triggered a multidisciplinary diagnostic work-up and resulted in the diagnosis of a clinically overt PTU-induced AAV.	Propylthiouracil	168-171	myeloperoxidase	Homo sapiens	22-37
25937486-5	2015	The unexpected double myeloperoxidase/proteinase 3-ANCA positivity triggered a multidisciplinary diagnostic work-up and resulted in the diagnosis of a clinically overt PTU-induced AAV.	Propylthiouracil	168-171	proteinase 3	Homo sapiens	38-50
25760705-5	2015	Propylthiouracil (PTU) is a potent antithyroid drug that acts by inhibiting the function of TPO.	Propylthiouracil	0-16	thyroid peroxidase	Homo sapiens	92-95
25760705-5	2015	Propylthiouracil (PTU) is a potent antithyroid drug that acts by inhibiting the function of TPO.	Propylthiouracil	18-21	thyroid peroxidase	Homo sapiens	92-95
25760705-8	2015	In order to determine the mode of its binding to peroxidases, the structure of the complex of LPO with PTU has been determined.	Propylthiouracil	103-106	lactoperoxidase	Homo sapiens	94-97
25760705-9	2015	It showed that PTU binds to LPO in the substrate-binding site on the distal haem side.	Propylthiouracil	15-18	lactoperoxidase	Homo sapiens	28-31
25760705-10	2015	The IC50 values for the inhibition of LPO and TPO by PTU are 47 and 30 microM, respectively.	Propylthiouracil	53-56	lactoperoxidase	Homo sapiens	38-41
25760705-10	2015	The IC50 values for the inhibition of LPO and TPO by PTU are 47 and 30 microM, respectively.	Propylthiouracil	53-56	thyroid peroxidase	Homo sapiens	46-49
25166026-2	2014	This review describes genetic factors that may contribute to PROP sensitivity including: (1) the variants of the TAS2R38 bitter receptor with their different affinities for the stimulus; (2) the gene that controls the gustin protein that acts as a salivary trophic factor for fungiform taste papillae; and (3) other specific salivary proteins that could be involved in facilitating the binding of the PROP molecule with its receptor.	Propylthiouracil	61-65	taste 2 receptor member 38	Homo sapiens	113-120
25287107-2	2014	Non-transgenic (NTG) and t/t mice were fed 6-n-propyl-2-thiouracil (PTU) to induce 100% expression of beta-MyHC.	Propylthiouracil	43-66	myosin heavy chain, cardiac muscle complex	Mus musculus	107-111
25287107-2	2014	Non-transgenic (NTG) and t/t mice were fed 6-n-propyl-2-thiouracil (PTU) to induce 100% expression of beta-MyHC.	Propylthiouracil	68-71	myosin heavy chain, cardiac muscle complex	Mus musculus	107-111
25287107-5	2014	In myocardium expressing beta-MyHC, values for k(-ADP) were higher in t/t(PTU) (24.8 +- 1.0 s(-1)) compared to NTG(PTU) (15.6 +- 1.3 s(-1), P &lt; 0.01), and k(+ATP) was not different.	Propylthiouracil	74-77	myosin heavy chain, cardiac muscle complex	Mus musculus	30-34
24945955-8	2014	In contrast, Cyb5R3 inhibitors (6-propyl-2-thiouracil, p-chloromercuriobenzoate, quercetin, mersalyl, and ebselen) showed similar patterns of inhibition of ROS generation and cytochrome c reduction.	Propylthiouracil	32-53	cytochrome b5 reductase 3	Homo sapiens	13-19
24945955-8	2014	In contrast, Cyb5R3 inhibitors (6-propyl-2-thiouracil, p-chloromercuriobenzoate, quercetin, mersalyl, and ebselen) showed similar patterns of inhibition of ROS generation and cytochrome c reduction.	Propylthiouracil	32-53	cytochrome c, somatic	Homo sapiens	175-187
25166026-2	2014	This review describes genetic factors that may contribute to PROP sensitivity including: (1) the variants of the TAS2R38 bitter receptor with their different affinities for the stimulus; (2) the gene that controls the gustin protein that acts as a salivary trophic factor for fungiform taste papillae; and (3) other specific salivary proteins that could be involved in facilitating the binding of the PROP molecule with its receptor.	Propylthiouracil	61-65	carbonic anhydrase 6	Homo sapiens	218-224
24595920-5	2014	Significantly increased activities of CAT and GPx were observed in 15 and 30 days PTU-treated rats.	Propylthiouracil	82-85	catalase	Rattus norvegicus	38-41
24610585-4	2014	The detection limits for methimazole, 6-methyl-2-thiouracil, 6-propyl-2-thiouracil, and 2-thiouracil were 0.1, 0.05, 0.05, and 0.01 muM, respectively.	Propylthiouracil	61-82	latexin	Homo sapiens	132-135
24811726-6	2014	PTU treatment increased surviving cell fraction at 2 Gy (SF2) from 56.9 +- 3.6 in controls to 75.0 +- 3.5 (p &lt; 0.05) and diminished radiation-induced apoptosis.	Propylthiouracil	0-3	serine and arginine rich splicing factor 1	Homo sapiens	57-60
24811726-9	2014	Forskolin (p &lt; 0.01) and dibutyryl cAMP (p &lt; 0.05) mimicked the effect of PTU on SF2.	Propylthiouracil	80-83	serine and arginine rich splicing factor 1	Homo sapiens	87-90
24604622-7	2014	In ApoE knockout mice, PTU-induced hypothyroidism triggered early VSMC apoptosis, increased oxidative stress, and accelerated atherosclerosis development.	Propylthiouracil	23-26	apolipoprotein E	Mus musculus	3-7
24272591-0	2014	Lupus nephritis with positive myeloperoxidase/proteinase 3-antineutrophil cytoplasmic autoantibody that developed after 17 years of propylthiouracil therapy.	Propylthiouracil	132-148	myeloperoxidase	Homo sapiens	30-45
24272591-0	2014	Lupus nephritis with positive myeloperoxidase/proteinase 3-antineutrophil cytoplasmic autoantibody that developed after 17 years of propylthiouracil therapy.	Propylthiouracil	132-148	proteinase 3	Homo sapiens	46-58
24783056-3	2013	PTU is both an inhibitor of TPO and type 1 deiodinase (D1), which catalyzes TH deiodination at both aromatic rings.	Propylthiouracil	0-3	thyroid peroxidase	Homo sapiens	28-31
24534176-1	2014	Recent reports suggest that polymorphisms in the carbonic anhydrase gene CA6 (also known as gustin) may explain additional variation in the bitterness of 6-n-propylthiouracil beyond that explained by variation in the bitter receptor gene TAS2R38.	Propylthiouracil	154-174	carbonic anhydrase 6	Homo sapiens	73-76
24534176-1	2014	Recent reports suggest that polymorphisms in the carbonic anhydrase gene CA6 (also known as gustin) may explain additional variation in the bitterness of 6-n-propylthiouracil beyond that explained by variation in the bitter receptor gene TAS2R38.	Propylthiouracil	154-174	carbonic anhydrase 6	Homo sapiens	92-98
24534176-1	2014	Recent reports suggest that polymorphisms in the carbonic anhydrase gene CA6 (also known as gustin) may explain additional variation in the bitterness of 6-n-propylthiouracil beyond that explained by variation in the bitter receptor gene TAS2R38.	Propylthiouracil	154-174	taste 2 receptor member 38	Homo sapiens	238-245
23780506-1	2014	This study was designed to show the effect of propylthiouracil treatment on sCD40L, high-sensitivity C-reactive protein, and fetuin-A levels on subjects with subclinical hyperthyroidism.	Propylthiouracil	46-62	C-reactive protein	Homo sapiens	101-119
23780506-1	2014	This study was designed to show the effect of propylthiouracil treatment on sCD40L, high-sensitivity C-reactive protein, and fetuin-A levels on subjects with subclinical hyperthyroidism.	Propylthiouracil	46-62	alpha 2-HS glycoprotein	Homo sapiens	125-133
23780506-7	2014	In subclinical hyperthyroidism patients, high fetuin-A levels before propylthiouracil treatment and decreases in these levels after treatment in cases with subclinical hyperthyroidism indicated the possibility of preventing long-term cardiac complications with propylthiouracil treatment.	Propylthiouracil	261-277	alpha 2-HS glycoprotein	Homo sapiens	46-54
23878414-6	2013	Still, there is ample evidence to indicate allelic variation in TAS2R38 predicts variation in bitterness of synthetic pharmaceuticals (e.g., propylthiouracil) and natural plant compounds (e.g., goitrin), and this variation associates with differential intake of alcohol and vegetables.	Propylthiouracil	141-157	taste 2 receptor member 38	Homo sapiens	64-71
24286160-14	2013	The increase in cutaneous and pulmonary expression of VEGF, ERK, Ras, and Rho in mice treated with HOCl was significantly prevented in mice co-administered with PTU.	Propylthiouracil	161-164	vascular endothelial growth factor A	Mus musculus	54-58
24025627-1	2013	BACKGROUND: Alleles of the receptor gene TAS2R38 are responsible in part for the variation in bitter taste perception of 6-n-propylthiouracil (PROP) and structurally similar compounds (eg, glucosinolates in cruciferous vegetables).	Propylthiouracil	121-141	taste 2 receptor member 38	Homo sapiens	41-48
24025627-1	2013	BACKGROUND: Alleles of the receptor gene TAS2R38 are responsible in part for the variation in bitter taste perception of 6-n-propylthiouracil (PROP) and structurally similar compounds (eg, glucosinolates in cruciferous vegetables).	Propylthiouracil	143-147	taste 2 receptor member 38	Homo sapiens	41-48
23224024-5	2013	In this review, we interpret the association of disordered NETs with autoimmune diseases, especially propylthiouracil-induced MPO-ANCA-associated vasculitis.	Propylthiouracil	101-117	myeloperoxidase	Homo sapiens	126-129
24286160-14	2013	The increase in cutaneous and pulmonary expression of VEGF, ERK, Ras, and Rho in mice treated with HOCl was significantly prevented in mice co-administered with PTU.	Propylthiouracil	161-164	mitogen-activated protein kinase 1	Mus musculus	60-63
23632915-1	2013	Mutational polymorphism in the TAS2R38 bitter taste receptor is a key determinant of threshold taste detection of isolated compounds, such as phenylthiocarbamide (PTC) and propylthiouracil (PROP), as well as complex orosensation-mediated traits such as diet choice and smoking habits.	Propylthiouracil	172-188	taste 2 receptor member 38	Homo sapiens	31-38
23632915-1	2013	Mutational polymorphism in the TAS2R38 bitter taste receptor is a key determinant of threshold taste detection of isolated compounds, such as phenylthiocarbamide (PTC) and propylthiouracil (PROP), as well as complex orosensation-mediated traits such as diet choice and smoking habits.	Propylthiouracil	190-194	taste 2 receptor member 38	Homo sapiens	31-38
23682719-0	2013	Crescentic glomerulonephritis due to IgA nephropathy or propylthiouracil-induced Mpo-Anca positive vasculitis?	Propylthiouracil	56-72	myeloperoxidase	Homo sapiens	81-84
23599216-5	2013	For example, common alleles for the genes TAS2R9 and TAS2R38 explain variable response to the bitter drugs ofloxacin in vitro and propylthiouracil in vivo.	Propylthiouracil	130-146	taste 2 receptor member 9	Homo sapiens	42-48
23599216-5	2013	For example, common alleles for the genes TAS2R9 and TAS2R38 explain variable response to the bitter drugs ofloxacin in vitro and propylthiouracil in vivo.	Propylthiouracil	130-146	taste 2 receptor member 38	Homo sapiens	53-60
23741366-3	2013	Here, we investigate the molecular determinants of the interaction of the TAS2R38 bitter taste receptor with its agonists phenylthiocarbamide (PTC) and propylthiouracil (PROP).	Propylthiouracil	152-168	taste 2 receptor member 38	Homo sapiens	74-81
23741366-3	2013	Here, we investigate the molecular determinants of the interaction of the TAS2R38 bitter taste receptor with its agonists phenylthiocarbamide (PTC) and propylthiouracil (PROP).	Propylthiouracil	170-174	taste 2 receptor member 38	Homo sapiens	74-81
23321072-5	2013	RESULTS: The results showed that apoptosis cells and activity of caspase3 were increased in the iodine-deficient and PTU-treatment rats (P &lt; 0.05, respectively).	Propylthiouracil	117-120	caspase 3	Rattus norvegicus	65-73
23321072-6	2013	The iodine-deficient and PTU-treatment pups showed significantly lower level of synaptotagmin-1 and PSD-95 in hippocampus than that of controls (P &lt; 0.05, respectively).	Propylthiouracil	25-28	synaptotagmin 1	Rattus norvegicus	80-95
23321072-6	2013	The iodine-deficient and PTU-treatment pups showed significantly lower level of synaptotagmin-1 and PSD-95 in hippocampus than that of controls (P &lt; 0.05, respectively).	Propylthiouracil	25-28	discs large MAGUK scaffold protein 4	Rattus norvegicus	100-106
23123290-2	2013	Mice and rats were fed an iodine-deficient, propylthiouracil diet resulting in ~100% expression of beta-MyHC in the ventricles.	Propylthiouracil	44-60	myosin heavy chain 13	Rattus norvegicus	104-108
23150524-8	2013	Abnormal cilia polarization, abnormal cilia-driven leftward flow at the gastrocoel roof plate (GRP), and aberrant expression of both Coco and Pitx2c were associated with abnormal LR symmetry observed following PTU exposure.	Propylthiouracil	210-213	DAN domain family member 5, BMP antagonist	Xenopus tropicalis	133-137
23150524-8	2013	Abnormal cilia polarization, abnormal cilia-driven leftward flow at the gastrocoel roof plate (GRP), and aberrant expression of both Coco and Pitx2c were associated with abnormal LR symmetry observed following PTU exposure.	Propylthiouracil	210-213	paired like homeodomain 2	Xenopus tropicalis	142-148
24252385-0	2013	Epitope analysis of anti-myeloperoxidase antibodies in propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis.	Propylthiouracil	55-71	myeloperoxidase	Homo sapiens	25-40
24252385-1	2013	INTRODUCTION: Increasing evidence has suggested that linear epitopes of antineutrophil cytoplasmic antibody (ANCA) directed to myeloperoxidase (MPO) might provide clues to the pathogenesis of propylthiouracil (PTU)-induced ANCA-associated vasculitis (AAV).	Propylthiouracil	192-208	myeloperoxidase	Homo sapiens	127-142
24252385-1	2013	INTRODUCTION: Increasing evidence has suggested that linear epitopes of antineutrophil cytoplasmic antibody (ANCA) directed to myeloperoxidase (MPO) might provide clues to the pathogenesis of propylthiouracil (PTU)-induced ANCA-associated vasculitis (AAV).	Propylthiouracil	192-208	myeloperoxidase	Homo sapiens	144-147
24252385-1	2013	INTRODUCTION: Increasing evidence has suggested that linear epitopes of antineutrophil cytoplasmic antibody (ANCA) directed to myeloperoxidase (MPO) might provide clues to the pathogenesis of propylthiouracil (PTU)-induced ANCA-associated vasculitis (AAV).	Propylthiouracil	210-213	myeloperoxidase	Homo sapiens	127-142
24252385-1	2013	INTRODUCTION: Increasing evidence has suggested that linear epitopes of antineutrophil cytoplasmic antibody (ANCA) directed to myeloperoxidase (MPO) might provide clues to the pathogenesis of propylthiouracil (PTU)-induced ANCA-associated vasculitis (AAV).	Propylthiouracil	210-213	myeloperoxidase	Homo sapiens	144-147
24252385-2	2013	This study mapped epitopes of MPO-ANCA in sera from patients with PTU-induced MPO-ANCA (with or without vasculitis) and primary AAV, aiming to analyze certain epitopes associated with the development of PTU-induced AAV.	Propylthiouracil	66-69	myeloperoxidase	Homo sapiens	30-33
24252385-2	2013	This study mapped epitopes of MPO-ANCA in sera from patients with PTU-induced MPO-ANCA (with or without vasculitis) and primary AAV, aiming to analyze certain epitopes associated with the development of PTU-induced AAV.	Propylthiouracil	66-69	myeloperoxidase	Homo sapiens	78-81
24252385-2	2013	This study mapped epitopes of MPO-ANCA in sera from patients with PTU-induced MPO-ANCA (with or without vasculitis) and primary AAV, aiming to analyze certain epitopes associated with the development of PTU-induced AAV.	Propylthiouracil	203-206	myeloperoxidase	Homo sapiens	30-33
24252385-4	2013	Sera from 17 patients with PTU-induced AAV, 17 patients with PTU-induced MPO-ANCA but without clinical evidence of vasculitis, and 64 patients with primary AAV were collected at presentation.	Propylthiouracil	61-64	myeloperoxidase	Homo sapiens	73-76
24252385-7	2013	RESULTS: Compared with patients with PTU-induced MPO-ANCA but without clinical vasculitis, sera from PTU-induced AAV patients showed significantly higher reactivity against the H1 fragment of MPO (optical density values: 0.17 (0.10 to 0.35) versus 0.10 (0.04 to 0.21), P = 0.038) and could recognize a significantly higher number of fragments (two (none to four) versus one (none to two), P = 0.026).	Propylthiouracil	37-40	myeloperoxidase	Homo sapiens	49-52
24252385-7	2013	RESULTS: Compared with patients with PTU-induced MPO-ANCA but without clinical vasculitis, sera from PTU-induced AAV patients showed significantly higher reactivity against the H1 fragment of MPO (optical density values: 0.17 (0.10 to 0.35) versus 0.10 (0.04 to 0.21), P = 0.038) and could recognize a significantly higher number of fragments (two (none to four) versus one (none to two), P = 0.026).	Propylthiouracil	37-40	myeloperoxidase	Homo sapiens	192-195
24252385-10	2013	CONCLUSIONS: Linear epitopes of MPO molecules might be associated closely with PTU-induced AAV.	Propylthiouracil	79-82	myeloperoxidase	Homo sapiens	32-35
23555788-1	2013	The genetic predisposition to taste 6-n-propylthiouracil (PROP) varies among individuals and is associated with salivary levels of Ps-1 and II-2 peptides, belonging to the basic proline-rich protein family (bPRP).	Propylthiouracil	36-56	taste 2 receptor member 62 pseudogene	Homo sapiens	131-144
23535535-2	2013	Variation of one bitter taste receptor gene, TAS2R38, which is associated with the differential sensitivity to phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP), has been demonstrated to affect the dietary intake pattern.	Propylthiouracil	141-161	taste 2 receptor member 38	Homo sapiens	45-52
23535535-2	2013	Variation of one bitter taste receptor gene, TAS2R38, which is associated with the differential sensitivity to phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP), has been demonstrated to affect the dietary intake pattern.	Propylthiouracil	163-167	taste 2 receptor member 38	Homo sapiens	45-52
23548722-1	2013	BACKGROUND/AIMS: Variations in bitter receptor gene TAS2R38 affect the perception of bitter-tasting compound 6-n-propylthiouracil (PROP).	Propylthiouracil	109-129	taste 2 receptor member 38	Homo sapiens	52-59
23548722-1	2013	BACKGROUND/AIMS: Variations in bitter receptor gene TAS2R38 affect the perception of bitter-tasting compound 6-n-propylthiouracil (PROP).	Propylthiouracil	131-135	taste 2 receptor member 38	Homo sapiens	52-59
22987056-3	2013	Significantly decreased activities of superoxide dismutase (SOD) and catalase (CAT) along with the translated products of SOD1 and SOD2 were observed in 7, 15 and 30 days old PTU-treated rats as compared to their respective controls.	Propylthiouracil	175-178	superoxide dismutase 1	Rattus norvegicus	60-63
22987056-3	2013	Significantly decreased activities of superoxide dismutase (SOD) and catalase (CAT) along with the translated products of SOD1 and SOD2 were observed in 7, 15 and 30 days old PTU-treated rats as compared to their respective controls.	Propylthiouracil	175-178	catalase	Rattus norvegicus	69-77
22987056-3	2013	Significantly decreased activities of superoxide dismutase (SOD) and catalase (CAT) along with the translated products of SOD1 and SOD2 were observed in 7, 15 and 30 days old PTU-treated rats as compared to their respective controls.	Propylthiouracil	175-178	catalase	Rattus norvegicus	79-82
22987056-3	2013	Significantly decreased activities of superoxide dismutase (SOD) and catalase (CAT) along with the translated products of SOD1 and SOD2 were observed in 7, 15 and 30 days old PTU-treated rats as compared to their respective controls.	Propylthiouracil	175-178	superoxide dismutase 1	Rattus norvegicus	122-126
22987056-3	2013	Significantly decreased activities of superoxide dismutase (SOD) and catalase (CAT) along with the translated products of SOD1 and SOD2 were observed in 7, 15 and 30 days old PTU-treated rats as compared to their respective controls.	Propylthiouracil	175-178	superoxide dismutase 2	Rattus norvegicus	131-135
22987056-4	2013	However, increase in translated product of CAT was seen in all age groups of PTU-treated rats.	Propylthiouracil	77-80	catalase	Rattus norvegicus	43-46
23174149-4	2013	OBJECTIVE: To analyze during early pregnancy expression of sodium/iodide symporter (NIS) and pendrin at the feto-maternal interface in situ in first trimester placentas, in vitro during human trophoblastic cell differentiation in presence or not of PTU.	Propylthiouracil	249-252	solute carrier family 5 member 5	Homo sapiens	84-87
23555788-1	2013	The genetic predisposition to taste 6-n-propylthiouracil (PROP) varies among individuals and is associated with salivary levels of Ps-1 and II-2 peptides, belonging to the basic proline-rich protein family (bPRP).	Propylthiouracil	58-62	taste 2 receptor member 62 pseudogene	Homo sapiens	131-144
22777766-0	2012	Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis.	Propylthiouracil	50-66	myeloperoxidase	Rattus norvegicus	183-198
22777766-3	2012	Propylthiouracil (PTU), an antithyroid drug, is associated with a risk of MPO antineutrophil cytoplasmic antibody (ANCA) production and MPO ANCA-associated vasculitis (MPO AAV).	Propylthiouracil	0-16	myeloperoxidase	Rattus norvegicus	74-77
22777766-3	2012	Propylthiouracil (PTU), an antithyroid drug, is associated with a risk of MPO antineutrophil cytoplasmic antibody (ANCA) production and MPO ANCA-associated vasculitis (MPO AAV).	Propylthiouracil	0-16	myeloperoxidase	Rattus norvegicus	136-139
22777766-3	2012	Propylthiouracil (PTU), an antithyroid drug, is associated with a risk of MPO antineutrophil cytoplasmic antibody (ANCA) production and MPO ANCA-associated vasculitis (MPO AAV).	Propylthiouracil	0-16	myeloperoxidase	Rattus norvegicus	136-139
22777766-3	2012	Propylthiouracil (PTU), an antithyroid drug, is associated with a risk of MPO antineutrophil cytoplasmic antibody (ANCA) production and MPO ANCA-associated vasculitis (MPO AAV).	Propylthiouracil	18-21	myeloperoxidase	Rattus norvegicus	74-77
22777766-3	2012	Propylthiouracil (PTU), an antithyroid drug, is associated with a risk of MPO antineutrophil cytoplasmic antibody (ANCA) production and MPO ANCA-associated vasculitis (MPO AAV).	Propylthiouracil	18-21	myeloperoxidase	Rattus norvegicus	136-139
22777766-3	2012	Propylthiouracil (PTU), an antithyroid drug, is associated with a risk of MPO antineutrophil cytoplasmic antibody (ANCA) production and MPO ANCA-associated vasculitis (MPO AAV).	Propylthiouracil	18-21	myeloperoxidase	Rattus norvegicus	136-139
22777766-4	2012	This study was undertaken to clarify the mechanism of MPO ANCA production, using the PTU-induced model of MPO AAV.	Propylthiouracil	85-88	myeloperoxidase	Rattus norvegicus	54-57
22777766-4	2012	This study was undertaken to clarify the mechanism of MPO ANCA production, using the PTU-induced model of MPO AAV.	Propylthiouracil	85-88	myeloperoxidase	Rattus norvegicus	106-109
22777766-11	2012	When rats were given oral PTU with intraperitoneal injection of PMA, pauci-immune glomerulonephritis and pulmonary capillaritis occurred with MPO ANCA production in the serum.	Propylthiouracil	26-29	myeloperoxidase	Rattus norvegicus	142-145
22656649-0	2012	3D structure prediction of TAS2R38 bitter receptors bound to agonists phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).	Propylthiouracil	100-120	taste 2 receptor member 38	Homo sapiens	27-34
22542736-4	2012	Direct exposure to PTU decreased the melanin content, up-regulated mRNA expressions of oculocutaneous albinism type 2 (OCA2), tyrosinase (TYR), dopachrometautomerase (DCT), tyrosinase-related protein 1 (TYRP1) and silver (SILV), and increased the protein expressions of TYR and SILV.	Propylthiouracil	19-22	oculocutaneous albinism II	Danio rerio	87-117
22542736-4	2012	Direct exposure to PTU decreased the melanin content, up-regulated mRNA expressions of oculocutaneous albinism type 2 (OCA2), tyrosinase (TYR), dopachrometautomerase (DCT), tyrosinase-related protein 1 (TYRP1) and silver (SILV), and increased the protein expressions of TYR and SILV.	Propylthiouracil	19-22	oculocutaneous albinism II	Danio rerio	119-123
22542736-4	2012	Direct exposure to PTU decreased the melanin content, up-regulated mRNA expressions of oculocutaneous albinism type 2 (OCA2), tyrosinase (TYR), dopachrometautomerase (DCT), tyrosinase-related protein 1 (TYRP1) and silver (SILV), and increased the protein expressions of TYR and SILV.	Propylthiouracil	19-22	tyrosinase	Danio rerio	126-136
22542736-4	2012	Direct exposure to PTU decreased the melanin content, up-regulated mRNA expressions of oculocutaneous albinism type 2 (OCA2), tyrosinase (TYR), dopachrometautomerase (DCT), tyrosinase-related protein 1 (TYRP1) and silver (SILV), and increased the protein expressions of TYR and SILV.	Propylthiouracil	19-22	tyrosinase	Danio rerio	138-141
22542736-4	2012	Direct exposure to PTU decreased the melanin content, up-regulated mRNA expressions of oculocutaneous albinism type 2 (OCA2), tyrosinase (TYR), dopachrometautomerase (DCT), tyrosinase-related protein 1 (TYRP1) and silver (SILV), and increased the protein expressions of TYR and SILV.	Propylthiouracil	19-22	tyrosinase-related protein 1a	Danio rerio	173-201
22542736-4	2012	Direct exposure to PTU decreased the melanin content, up-regulated mRNA expressions of oculocutaneous albinism type 2 (OCA2), tyrosinase (TYR), dopachrometautomerase (DCT), tyrosinase-related protein 1 (TYRP1) and silver (SILV), and increased the protein expressions of TYR and SILV.	Propylthiouracil	19-22	tyrosinase-related protein 1a	Danio rerio	203-208
22542736-4	2012	Direct exposure to PTU decreased the melanin content, up-regulated mRNA expressions of oculocutaneous albinism type 2 (OCA2), tyrosinase (TYR), dopachrometautomerase (DCT), tyrosinase-related protein 1 (TYRP1) and silver (SILV), and increased the protein expressions of TYR and SILV.	Propylthiouracil	19-22	tyrosinase	Danio rerio	203-206
22522343-4	2012	SOD1 activity remained unchanged in persistent (PTU-treatment from birth to 90days old) hypothyroid rats as compared to euthyroid.	Propylthiouracil	48-51	superoxide dismutase 1	Rattus norvegicus	0-4
22522343-5	2012	However, a decreased activity of SOD1 was recorded in transient (PTU-treatment from birth to 30days then withdrawal till 90days old) hypothyroid rats with respect to control rats.	Propylthiouracil	65-68	superoxide dismutase 1	Rattus norvegicus	33-37
22919057-7	2012	Thrb(PV/+)mice treated with PTU (Thrb(PV/+)-PTU) spontaneously developed FTC similar to human thyroid cancer, but wild-type siblings treated with PTU did not.	Propylthiouracil	28-31	thyroid hormone receptor beta	Mus musculus	0-4
22919057-7	2012	Thrb(PV/+)mice treated with PTU (Thrb(PV/+)-PTU) spontaneously developed FTC similar to human thyroid cancer, but wild-type siblings treated with PTU did not.	Propylthiouracil	28-31	thyroid hormone receptor beta	Mus musculus	33-37
22919057-7	2012	Thrb(PV/+)mice treated with PTU (Thrb(PV/+)-PTU) spontaneously developed FTC similar to human thyroid cancer, but wild-type siblings treated with PTU did not.	Propylthiouracil	44-47	thyroid hormone receptor beta	Mus musculus	0-4
22919057-7	2012	Thrb(PV/+)mice treated with PTU (Thrb(PV/+)-PTU) spontaneously developed FTC similar to human thyroid cancer, but wild-type siblings treated with PTU did not.	Propylthiouracil	44-47	thyroid hormone receptor beta	Mus musculus	33-37
22919057-7	2012	Thrb(PV/+)mice treated with PTU (Thrb(PV/+)-PTU) spontaneously developed FTC similar to human thyroid cancer, but wild-type siblings treated with PTU did not.	Propylthiouracil	44-47	thyroid hormone receptor beta	Mus musculus	0-4
22919057-7	2012	Thrb(PV/+)mice treated with PTU (Thrb(PV/+)-PTU) spontaneously developed FTC similar to human thyroid cancer, but wild-type siblings treated with PTU did not.	Propylthiouracil	44-47	thyroid hormone receptor beta	Mus musculus	33-37
22076484-4	2012	The decreased translated products (SOD1 and SOD2) and the unchanged activity of SOD in cerebral cortex of PTU-treated rats were increased on supplementation of curcumin to the hypothyroid rats.	Propylthiouracil	106-109	superoxide dismutase 1	Rattus norvegicus	35-39
22076484-4	2012	The decreased translated products (SOD1 and SOD2) and the unchanged activity of SOD in cerebral cortex of PTU-treated rats were increased on supplementation of curcumin to the hypothyroid rats.	Propylthiouracil	106-109	superoxide dismutase 2	Rattus norvegicus	44-48
22076484-5	2012	Declined translated products of SOD1 and SOD2 in cerebellum of PTU-treated rats were alleviated on administration of curcumin to hypothyroid rats.	Propylthiouracil	63-66	superoxide dismutase 1	Rattus norvegicus	32-36
22076484-5	2012	Declined translated products of SOD1 and SOD2 in cerebellum of PTU-treated rats were alleviated on administration of curcumin to hypothyroid rats.	Propylthiouracil	63-66	superoxide dismutase 2	Rattus norvegicus	41-45
22656649-1	2012	The G protein-coupled receptor (GPCR) TAS2R38 is a bitter taste receptor that can respond to bitter compounds such as phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).	Propylthiouracil	148-168	taste 2 receptor member 38	Homo sapiens	38-45
22656649-1	2012	The G protein-coupled receptor (GPCR) TAS2R38 is a bitter taste receptor that can respond to bitter compounds such as phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).	Propylthiouracil	170-174	taste 2 receptor member 38	Homo sapiens	38-45
22656649-0	2012	3D structure prediction of TAS2R38 bitter receptors bound to agonists phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).	Propylthiouracil	122-126	taste 2 receptor member 38	Homo sapiens	27-34
21825964-2	2012	The aim of this study is to investigate the CIMT in patients with Graves" hyperthyroidism and the effect of propylthiouracil (PTU) therapy on CIMT.	Propylthiouracil	108-124	CIMT	Homo sapiens	142-146
21909131-8	2012	To understand the role of TH in thyroid carcinogenesis, we blocked the production of TH by treating Thrb(PV/PV) mice with propylthiouracil (Thrb(PV/PV)-PTU mice) and compared the development of thyroid cancer in Thrb(PV/PV)-PTU and untreated Thrb(PV/PV) mice.	Propylthiouracil	122-138	thyroid hormone receptor beta	Mus musculus	140-144
21909131-8	2012	To understand the role of TH in thyroid carcinogenesis, we blocked the production of TH by treating Thrb(PV/PV) mice with propylthiouracil (Thrb(PV/PV)-PTU mice) and compared the development of thyroid cancer in Thrb(PV/PV)-PTU and untreated Thrb(PV/PV) mice.	Propylthiouracil	122-138	thyroid hormone receptor beta	Mus musculus	140-144
21909131-8	2012	To understand the role of TH in thyroid carcinogenesis, we blocked the production of TH by treating Thrb(PV/PV) mice with propylthiouracil (Thrb(PV/PV)-PTU mice) and compared the development of thyroid cancer in Thrb(PV/PV)-PTU and untreated Thrb(PV/PV) mice.	Propylthiouracil	122-138	thyroid hormone receptor beta	Mus musculus	140-144
22595232-9	2012	Dcx protein levels in the cerebella of iodine-deficient and PTU-treated rats were significantly downregulated on PND14.	Propylthiouracil	60-63	doublecortin	Rattus norvegicus	0-3
22595232-10	2012	Interestingly, iodine deficiency and PTU treatment upregulated the levels of Dcx protein on PND21 and 28.	Propylthiouracil	37-40	doublecortin	Rattus norvegicus	77-80
22595232-11	2012	Reelin expressions in iodine-deficient and PTU-treated rats were significantly decreased on PND14 and 21.	Propylthiouracil	43-46	reelin	Rattus norvegicus	0-6
21825964-2	2012	The aim of this study is to investigate the CIMT in patients with Graves" hyperthyroidism and the effect of propylthiouracil (PTU) therapy on CIMT.	Propylthiouracil	126-129	CIMT	Homo sapiens	142-146
21825964-5	2012	CIMT was measured before and after the PTU therapy in patients with Graves" hyperthyroidism.	Propylthiouracil	39-42	CIMT	Homo sapiens	0-4
21825964-11	2012	Treatment of Graves" hyperthyroidism with PTU decreases the CIMT.	Propylthiouracil	42-45	CIMT	Homo sapiens	60-64
22253429-0	2012	Reduced hippocampal brain-derived neurotrophic factor (BDNF) in neonatal rats after prenatal exposure to propylthiouracil (PTU).	Propylthiouracil	105-121	brain-derived neurotrophic factor	Rattus norvegicus	20-53
22253429-0	2012	Reduced hippocampal brain-derived neurotrophic factor (BDNF) in neonatal rats after prenatal exposure to propylthiouracil (PTU).	Propylthiouracil	105-121	brain-derived neurotrophic factor	Rattus norvegicus	55-59
22253429-0	2012	Reduced hippocampal brain-derived neurotrophic factor (BDNF) in neonatal rats after prenatal exposure to propylthiouracil (PTU).	Propylthiouracil	123-126	brain-derived neurotrophic factor	Rattus norvegicus	20-53
22253429-0	2012	Reduced hippocampal brain-derived neurotrophic factor (BDNF) in neonatal rats after prenatal exposure to propylthiouracil (PTU).	Propylthiouracil	123-126	brain-derived neurotrophic factor	Rattus norvegicus	55-59
22253429-7	2012	BDNF levels were measured by ELISA at 3 or 7 d after birth in different regions of the brains of rats exposed to propylthiouracil (PTU) in the drinking water.	Propylthiouracil	113-129	brain-derived neurotrophic factor	Rattus norvegicus	0-4
22348574-3	2012	OBJECTIVE: To report a case of a 57-year-old woman with hyperthyroidism who developed myeloperoxidase (MPO)-ANCA erythema nodosum after PTU treatment for 11 months.	Propylthiouracil	136-139	myeloperoxidase	Homo sapiens	86-101
22348574-3	2012	OBJECTIVE: To report a case of a 57-year-old woman with hyperthyroidism who developed myeloperoxidase (MPO)-ANCA erythema nodosum after PTU treatment for 11 months.	Propylthiouracil	136-139	myeloperoxidase	Homo sapiens	103-106
21611807-7	2011	The upregulation of caveolin-1 and the downregulation of synaptotagmin-1 were observed in both iodine-deficient and PTU-treated rats.	Propylthiouracil	116-119	caveolin 1	Rattus norvegicus	20-30
22024186-9	2012	PTU-induced hypothyroidism delayed the appearance of StarD6 immunopositive cells until P7.	Propylthiouracil	0-3	StAR-related lipid transfer domain containing 6	Rattus norvegicus	53-59
22024186-10	2012	Moreover, the nuclear localization of StarD6 in PTU-treated rats was not obvious at P14.	Propylthiouracil	48-51	StAR-related lipid transfer domain containing 6	Rattus norvegicus	38-44
22538212-2	2012	PRESENTATION AND INTERVENTION: A 28-year-old woman with PTU-treated hyperthyroidism presented with fever, purpura, pulmonary cavitations and ANCA to myeloperoxidase, bactericidal/permeability-increasing protein (BPI), proteinase-3 and elastase.	Propylthiouracil	56-59	myeloperoxidase	Homo sapiens	149-164
22538212-2	2012	PRESENTATION AND INTERVENTION: A 28-year-old woman with PTU-treated hyperthyroidism presented with fever, purpura, pulmonary cavitations and ANCA to myeloperoxidase, bactericidal/permeability-increasing protein (BPI), proteinase-3 and elastase.	Propylthiouracil	56-59	bactericidal permeability increasing protein	Homo sapiens	166-210
22538212-2	2012	PRESENTATION AND INTERVENTION: A 28-year-old woman with PTU-treated hyperthyroidism presented with fever, purpura, pulmonary cavitations and ANCA to myeloperoxidase, bactericidal/permeability-increasing protein (BPI), proteinase-3 and elastase.	Propylthiouracil	56-59	bactericidal permeability increasing protein	Homo sapiens	212-215
22538212-2	2012	PRESENTATION AND INTERVENTION: A 28-year-old woman with PTU-treated hyperthyroidism presented with fever, purpura, pulmonary cavitations and ANCA to myeloperoxidase, bactericidal/permeability-increasing protein (BPI), proteinase-3 and elastase.	Propylthiouracil	56-59	proteinase 3	Homo sapiens	218-243
22312435-6	2012	PROP super-tastings was strongly associated with the "taster" variant (PAV haplotype) of TAS2R38 and the A allele of rs2274333 polymorphism in the gustin gene and nontasting was associated with the minor alleles at both loci.	Propylthiouracil	0-4	taste 2 receptor member 38	Homo sapiens	89-96
22312435-6	2012	PROP super-tastings was strongly associated with the "taster" variant (PAV haplotype) of TAS2R38 and the A allele of rs2274333 polymorphism in the gustin gene and nontasting was associated with the minor alleles at both loci.	Propylthiouracil	0-4	carbonic anhydrase 6	Homo sapiens	147-153
22312435-8	2012	These data show for the first time that responsiveness to PROP is associated with salivary levels of II-2 peptide and Ps-1 protein, which are products of the PRB1 gene.	Propylthiouracil	58-62	taste 2 receptor member 62 pseudogene	Homo sapiens	118-122
22312435-8	2012	These data show for the first time that responsiveness to PROP is associated with salivary levels of II-2 peptide and Ps-1 protein, which are products of the PRB1 gene.	Propylthiouracil	58-62	proline rich protein BstNI subfamily 1	Homo sapiens	158-162
21611807-7	2011	The upregulation of caveolin-1 and the downregulation of synaptotagmin-1 were observed in both iodine-deficient and PTU-treated rats.	Propylthiouracil	116-119	synaptotagmin 1	Rattus norvegicus	57-72
21910767-11	2011	In support of this hypothesis, hypothyroxinaemia induced by propylthiouracil treatment of dams decreased the number of beta-galactosidase-positive neurones in cortical layer 2/3 of newborn Slco1c1-Cre/Rosa26 mice.	Propylthiouracil	60-76	galactosidase, beta 1	Mus musculus	119-137
21910767-11	2011	In support of this hypothesis, hypothyroxinaemia induced by propylthiouracil treatment of dams decreased the number of beta-galactosidase-positive neurones in cortical layer 2/3 of newborn Slco1c1-Cre/Rosa26 mice.	Propylthiouracil	60-76	solute carrier organic anion transporter family, member 1c1	Mus musculus	189-196
21910767-11	2011	In support of this hypothesis, hypothyroxinaemia induced by propylthiouracil treatment of dams decreased the number of beta-galactosidase-positive neurones in cortical layer 2/3 of newborn Slco1c1-Cre/Rosa26 mice.	Propylthiouracil	60-76	gene trap ROSA 26, Philippe Soriano	Mus musculus	201-207
22027146-13	2011	Both long term treatment with 6-propyl-2-thiouracil and short-term treatment with 0.05% methimazole/1% sodium perchlorate (both treatments render mice hypothyroid) resulted in up-regulation of Barhl1.	Propylthiouracil	30-51	BarH like homeobox 1	Mus musculus	193-199
22001906-4	2011	Though unresponsive to glucocorticoids, treatment with anti-thyroid hormone drugs (propylthiouracil or methimazole) completely rescues SMRT-induced RDS, suggesting an unrecognized and essential role for the thyroid hormone receptor (TR) in lung development.	Propylthiouracil	83-99	nuclear receptor co-repressor 2	Mus musculus	135-139
21964592-11	2011	Hypothyroidism induced by low-iodine diet and oral propylthiouracil revealed a blunted TSH response in Pitx2(flox/-);Tg(Tshb-cre) mice.	Propylthiouracil	51-67	paired-like homeodomain transcription factor 2	Mus musculus	103-108
21964592-11	2011	Hypothyroidism induced by low-iodine diet and oral propylthiouracil revealed a blunted TSH response in Pitx2(flox/-);Tg(Tshb-cre) mice.	Propylthiouracil	51-67	thyroid stimulating hormone, beta subunit	Mus musculus	120-124
21820424-0	2011	Clinical efficacy of propylthiouracil and its influence on prolactin in psoriatic patients.	Propylthiouracil	21-37	prolactin	Homo sapiens	59-68
21820424-3	2011	Hence, the objective is to find the effect of PTU on PRL level in psoriatic patients.	Propylthiouracil	46-49	prolactin	Homo sapiens	53-56
21820424-10	2011	CONCLUSION: Since PRL is a growth hormone involved in hyperproliferation of keratinocytes, this study reveals the antiproliferative effect of PTU.	Propylthiouracil	142-145	prolactin	Homo sapiens	18-21
20951798-0	2011	Akt1 protects against germ cell apoptosis in the postnatal mouse testis following lactational exposure to 6-N-propylthiouracil.	Propylthiouracil	106-126	thymoma viral proto-oncogene 1	Mus musculus	0-4
21669406-2	2011	We determined if propylthiouracil (PTU)-induced hypothyroidismin hamsters (HH) altered dopamine D1 receptor expression, D1 receptor-modulated ventilation, and ventilatory chemoreflex activation by hypoxia or hypercapnia.	Propylthiouracil	17-33	dopamine receptor D1	Homo sapiens	87-107
21669406-2	2011	We determined if propylthiouracil (PTU)-induced hypothyroidismin hamsters (HH) altered dopamine D1 receptor expression, D1 receptor-modulated ventilation, and ventilatory chemoreflex activation by hypoxia or hypercapnia.	Propylthiouracil	35-38	dopamine receptor D1	Homo sapiens	87-107
21163912-3	2011	The most studied phenotype is propylthiouracil bitterness, which is mediated primarily by the TAS2R38 gene and possibly others.	Propylthiouracil	30-46	taste 2 receptor member 38	Homo sapiens	94-101
22513421-4	2011	Neonatally administered PTU promoted a delay in the differentiation of Sertoli cells as evaluated by the expression of clusterin using immunohistochemistry and RT-PCR.	Propylthiouracil	24-27	clusterin	Rattus norvegicus	119-128
22513421-5	2011	Clusterin had different expression levels in control and PTU-treated animals, but under both conditions the highest levels were found in 35-day-old rats.	Propylthiouracil	57-60	clusterin	Rattus norvegicus	0-9
22513421-6	2011	In addition, clusterin displayed a cytoplasmic localization in control testes, but appeared located in the nucleus in PTU-treated animals.	Propylthiouracil	118-121	clusterin	Rattus norvegicus	13-22
22513421-8	2011	The expression levels of proapoptotic genes like BAX or BAD were different between control and PTU-treated rats; although in both groups the highest level was found at the same age (days).	Propylthiouracil	95-98	BCL2 associated X, apoptosis regulator	Rattus norvegicus	49-52
20980355-8	2011	Human PROP sensitivity is determined by the combination of each of these 3 polymorphisms within the TAS2R38 gene.	Propylthiouracil	6-10	taste 2 receptor member 38	Homo sapiens	100-107
21631296-3	2011	Sensitivity to PROP is a heritable trait based on the TAS2R38 gene on chromosome 7q34.	Propylthiouracil	15-19	taste 2 receptor member 38	Homo sapiens	54-61
21631296-4	2011	In a recent study we demonstrated an association between PROP sensitivity and the single-nucleotide polymorphism (SNP) rs2274333 (+292A/G) within a coding sequence of the gustin/carbonic anhydrase VI gene.	Propylthiouracil	57-61	carbonic anhydrase 6	Homo sapiens	171-177
21273639-0	2011	Proliferating cell nuclear antigen as a molecular biomarker for spermatogenesis in PTU-induced hypothyroidism of rats.	Propylthiouracil	83-86	proliferating cell nuclear antigen	Rattus norvegicus	0-34
21422690-3	2011	She was diagnosed with Evans syndrome associated with Graves" disease and treated with propylthiouracil without corticosteroids, which normalized her thyroglobulin level.	Propylthiouracil	87-103	thyroglobulin	Homo sapiens	150-163
19997993-7	2011	Without going through water maze test, iodine-deficient and 15 ppm PTU-treatment groups showed significantly lower CaMKII and calmodulin and significantly higher calcineurin than the controls in hippocampal CA1 and CA3 regions (P &lt; 0.05).	Propylthiouracil	67-70	calmodulin 1	Rattus norvegicus	126-136
19997993-7	2011	Without going through water maze test, iodine-deficient and 15 ppm PTU-treatment groups showed significantly lower CaMKII and calmodulin and significantly higher calcineurin than the controls in hippocampal CA1 and CA3 regions (P &lt; 0.05).	Propylthiouracil	67-70	carbonic anhydrase 1	Rattus norvegicus	207-210
19997993-7	2011	Without going through water maze test, iodine-deficient and 15 ppm PTU-treatment groups showed significantly lower CaMKII and calmodulin and significantly higher calcineurin than the controls in hippocampal CA1 and CA3 regions (P &lt; 0.05).	Propylthiouracil	67-70	carbonic anhydrase 3	Rattus norvegicus	215-218
19874374-7	2010	This may be because PTU binds to myeloperoxidase (MPO) inside neutrophils, altering its configuration and thus causing antibody formation to this abnormal MPO-PTU configuration, which would not be detected by standard laboratory techniques.	Propylthiouracil	20-23	myeloperoxidase	Homo sapiens	33-48
20551074-3	2010	Individuals vary in ability to perceive synthetic compounds similar to goitrin, such as 6-propyl-2-thiouracil (PROP) and phenylthiocarbamide (PTC), as the result of mutations in the TAS2R38 gene, which encodes a bitter taste receptor.	Propylthiouracil	88-109	taste 2 receptor member 38	Homo sapiens	182-189
20551074-3	2010	Individuals vary in ability to perceive synthetic compounds similar to goitrin, such as 6-propyl-2-thiouracil (PROP) and phenylthiocarbamide (PTC), as the result of mutations in the TAS2R38 gene, which encodes a bitter taste receptor.	Propylthiouracil	111-115	taste 2 receptor member 38	Homo sapiens	182-189
20605662-2	2010	Detection of antineutrophil cytoplasmic antibodies (ANCA) against myeloperoxidase, proteinase 3 and elastase led to suspect PTU induced vasculitis.	Propylthiouracil	124-127	myeloperoxidase	Homo sapiens	66-81
20605662-2	2010	Detection of antineutrophil cytoplasmic antibodies (ANCA) against myeloperoxidase, proteinase 3 and elastase led to suspect PTU induced vasculitis.	Propylthiouracil	124-127	proteinase 3	Homo sapiens	83-108
20631203-0	2010	Sensitivity to 6-n-propylthiouracil is associated with gustin (carbonic anhydrase VI) gene polymorphism, salivary zinc, and body mass index in humans.	Propylthiouracil	15-35	carbonic anhydrase 6	Homo sapiens	55-61
20631203-1	2010	BACKGROUND: The individual ability to taste 6-n-propylthiouracil (PROP) may be correlated with body mass index (BMI) and differences in the salivary proteins involved in taste function, such as the zinc-dependent enzyme gustin, which is a trophic factor of taste buds.	Propylthiouracil	44-64	carbonic anhydrase 6	Homo sapiens	220-226
20631203-1	2010	BACKGROUND: The individual ability to taste 6-n-propylthiouracil (PROP) may be correlated with body mass index (BMI) and differences in the salivary proteins involved in taste function, such as the zinc-dependent enzyme gustin, which is a trophic factor of taste buds.	Propylthiouracil	66-70	carbonic anhydrase 6	Homo sapiens	220-226
20631203-2	2010	OBJECTIVE: We investigated the possible association of PROP taste responsiveness with gustin gene polymorphism rs2274333 (A/G), salivary ionic zinc concentrations, and BMI.	Propylthiouracil	55-59	carbonic anhydrase 6	Homo sapiens	86-92
20631203-11	2010	Our data showed a direct association between PROP sensitivity and a polymorphism in the gustin gene that is hypothesized to affect its function.	Propylthiouracil	45-49	carbonic anhydrase 6	Homo sapiens	88-94
20924043-0	2010	Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic acute regulatory protein expression in rat granulosa cells.	Propylthiouracil	23-39	steroidogenic acute regulatory protein	Rattus norvegicus	91-129
20924043-4	2010	Notably, we found that PTU treatment enhanced the conversion of cholesterol into pregnenolone, whereas the protein level of the cytochrome P450 side-chain cleavage enzyme (P450scc, which is the enzyme responding to this conversion) was not affected.	Propylthiouracil	23-26	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	172-179
20924043-5	2010	Interestingly, the levels of steroidogenic acute regulatory protein (StAR) in both total cell lysate and the mitochondrial fraction were significantly increased by PTU treatment.	Propylthiouracil	164-167	steroidogenic acute regulatory protein	Rattus norvegicus	29-67
20924043-5	2010	Interestingly, the levels of steroidogenic acute regulatory protein (StAR) in both total cell lysate and the mitochondrial fraction were significantly increased by PTU treatment.	Propylthiouracil	164-167	steroidogenic acute regulatory protein	Rattus norvegicus	69-73
19874374-7	2010	This may be because PTU binds to myeloperoxidase (MPO) inside neutrophils, altering its configuration and thus causing antibody formation to this abnormal MPO-PTU configuration, which would not be detected by standard laboratory techniques.	Propylthiouracil	20-23	myeloperoxidase	Homo sapiens	50-53
19874374-7	2010	This may be because PTU binds to myeloperoxidase (MPO) inside neutrophils, altering its configuration and thus causing antibody formation to this abnormal MPO-PTU configuration, which would not be detected by standard laboratory techniques.	Propylthiouracil	20-23	myeloperoxidase	Homo sapiens	155-158
19874374-7	2010	This may be because PTU binds to myeloperoxidase (MPO) inside neutrophils, altering its configuration and thus causing antibody formation to this abnormal MPO-PTU configuration, which would not be detected by standard laboratory techniques.	Propylthiouracil	159-162	myeloperoxidase	Homo sapiens	50-53
19874374-7	2010	This may be because PTU binds to myeloperoxidase (MPO) inside neutrophils, altering its configuration and thus causing antibody formation to this abnormal MPO-PTU configuration, which would not be detected by standard laboratory techniques.	Propylthiouracil	159-162	myeloperoxidase	Homo sapiens	155-158
19779476-8	2010	PROP nontaster males had higher BMI z-scores than taster-males and females in both groups (P &lt; 0.05), but due to a three-way interaction between PROP phenotype, TAS2R38 genotype, and sex, this relationship was only true for children who were homozygous for the bitter-insensitive allele (P &lt; 0.0005).	Propylthiouracil	0-4	taste 2 receptor member 38	Homo sapiens	164-171
20123122-6	2010	A distinct increase in cell proliferation as indicated by proliferating cell nuclear antigen (PCNA) immunoreactivity was observed in the internal granular layer of cerebellum of 7 days old hypothyroid rats and significant drop in PCNA positive cells in the cerebellar molecular layer and internal granular layer of 30 days old PTU treated rats as compared to controls.	Propylthiouracil	327-330	proliferating cell nuclear antigen	Rattus norvegicus	94-98
20412599-6	2010	Downregulation of doublecortin and upregulation of NCAM-180 were observed in iodine-deficient and 15 ppm PTU-treated rats from PN14 on.	Propylthiouracil	105-108	doublecortin	Rattus norvegicus	18-30
20412599-6	2010	Downregulation of doublecortin and upregulation of NCAM-180 were observed in iodine-deficient and 15 ppm PTU-treated rats from PN14 on.	Propylthiouracil	105-108	neural cell adhesion molecule 1	Rattus norvegicus	51-55
20168071-0	2009	[A case of MPO-ANCA positive vasculitis associated with alveolar hemorrhage and progressive glomerulonephritis following propylthiouracil treatment, the interval was 6 years and 4 months].	Propylthiouracil	121-137	myeloperoxidase	Homo sapiens	11-14
20194094-0	2010	Influences of hypertonic and hypovolemic treatments on vasopressin response in propylthiouracil (PTU) induced hypothyroid rat and effect on supplementation with L-thyroxine.	Propylthiouracil	79-95	arginine vasopressin	Rattus norvegicus	55-66
20194094-0	2010	Influences of hypertonic and hypovolemic treatments on vasopressin response in propylthiouracil (PTU) induced hypothyroid rat and effect on supplementation with L-thyroxine.	Propylthiouracil	97-100	arginine vasopressin	Rattus norvegicus	55-66
20194094-1	2010	This study was performed to investigate the effects of L-thyroxine treatment on plasma vasopressin (AVP) levels in rats with hypothyroidism induced by propylthiouracil (PTU).	Propylthiouracil	151-167	arginine vasopressin	Rattus norvegicus	87-98
20194094-10	2010	Vasopressin responses to basal, hypovolemic and hypertonic stimulations were the lowest in the PTU group (P &lt; 0.001).	Propylthiouracil	95-98	arginine vasopressin	Rattus norvegicus	0-11
20194094-11	2010	The results of the present study show that basal and stimulated plasma vasopressin levels are reduced in PTU-induced hypothyroidism.	Propylthiouracil	105-108	arginine vasopressin	Rattus norvegicus	71-82
20041985-5	2010	PTU produced a stepwise decrease in serum total T(4), and a stepwise increase in serum thyroid-stimulating hormone (TSH), in type 2 deiodinase mRNA expression and enzyme activity in the brain, and in the expression of the mRNA encoding the tri-iodothyronine (T(3)) transporter MCT8 in the postnatal day (P) 15 cortex.	Propylthiouracil	0-3	solute carrier family 16 member 2	Rattus norvegicus	277-281
20029917-3	2010	These studies reveal that the antithyroid drugs methimazole (MMI), 6-n-propyl-2-thiouracil (PTU), and 6-methyl-2-thiouracil (MTU), which contain thione moieties, significantly reduce the tyrosine nitration of both BSA and cytochrome c.	Propylthiouracil	67-90	cytochrome c, somatic	Homo sapiens	222-234
19633808-0	2010	Propylthiouracil, independent of its antithyroid effect, promotes vascular smooth muscle cells differentiation via PTEN induction.	Propylthiouracil	0-16	phosphatase and tensin homolog	Rattus norvegicus	115-119
19633808-4	2010	In vitro, PTU may convert VSMCs from a serum-induced dedifferentiation state to a differentiated state, as indicated by a spindle-shaped morphology and an increase in the expression of SMC differentiation marker contractile proteins, including calponin and smooth muscle (SM)-myosin heavy chain (SM-MHC).	Propylthiouracil	10-13	myosin heavy chain 11	Rattus norvegicus	257-294
19633808-4	2010	In vitro, PTU may convert VSMCs from a serum-induced dedifferentiation state to a differentiated state, as indicated by a spindle-shaped morphology and an increase in the expression of SMC differentiation marker contractile proteins, including calponin and smooth muscle (SM)-myosin heavy chain (SM-MHC).	Propylthiouracil	10-13	myosin heavy chain 11	Rattus norvegicus	296-302
19633808-6	2010	Furthermore, PTU enhanced the expression of PTEN and inhibition of PTEN by siRNA knockdown blocked PTU-induced activation of contractile proteins expression and promoter activity.	Propylthiouracil	13-16	phosphatase and tensin homolog	Rattus norvegicus	44-48
19633808-6	2010	Furthermore, PTU enhanced the expression of PTEN and inhibition of PTEN by siRNA knockdown blocked PTU-induced activation of contractile proteins expression and promoter activity.	Propylthiouracil	99-102	phosphatase and tensin homolog	Rattus norvegicus	44-48
19633808-6	2010	Furthermore, PTU enhanced the expression of PTEN and inhibition of PTEN by siRNA knockdown blocked PTU-induced activation of contractile proteins expression and promoter activity.	Propylthiouracil	99-102	phosphatase and tensin homolog	Rattus norvegicus	67-71
19633808-7	2010	In the rat carotid injury model, PTU reversed the down-regulation of contractile proteins and up-regulated PTEN in the neointima induced by balloon injury.	Propylthiouracil	33-36	phosphatase and tensin homolog	Rattus norvegicus	107-111
19633808-8	2010	Propylthiouracil promotes VSMC differentiation, at lest in part, via induction of the PTEN-mediated pathway.	Propylthiouracil	0-16	phosphatase and tensin homolog	Rattus norvegicus	86-90
19851036-0	2010	A long-term follow-up of serum myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) in patients with Graves disease treated with propylthiouracil.	Propylthiouracil	141-157	myeloperoxidase	Homo sapiens	86-89
19851036-1	2010	Propylthiouracil (PTU) is known to induce myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) in patients with Graves disease (GD).	Propylthiouracil	0-16	myeloperoxidase	Homo sapiens	97-100
19851036-1	2010	Propylthiouracil (PTU) is known to induce myeloperoxidase antineutrophil cytoplasmic antibodies (MPO-ANCA) in patients with Graves disease (GD).	Propylthiouracil	18-21	myeloperoxidase	Homo sapiens	97-100
19851036-2	2010	Previously, we showed that serum MPO-ANCA were frequently seen in patients with GD treated with PTU.	Propylthiouracil	96-99	myeloperoxidase	Homo sapiens	33-36
19851036-6	2010	The initial MPO-ANCA levels were significantly higher in those antibody titers remained positive for longer than 5 years (n=5) than in those titers turned to be negative within 5 years after PTU withdrawal (n=3) (203 +/- 256 EU and 22 +/- 2 EU, respectively, P=0.04), but there were no significant differences in age, gender, duration of PTU therapy or dosage of PTU.	Propylthiouracil	191-194	myeloperoxidase	Homo sapiens	12-15
19851036-6	2010	The initial MPO-ANCA levels were significantly higher in those antibody titers remained positive for longer than 5 years (n=5) than in those titers turned to be negative within 5 years after PTU withdrawal (n=3) (203 +/- 256 EU and 22 +/- 2 EU, respectively, P=0.04), but there were no significant differences in age, gender, duration of PTU therapy or dosage of PTU.	Propylthiouracil	338-341	myeloperoxidase	Homo sapiens	12-15
19851036-6	2010	The initial MPO-ANCA levels were significantly higher in those antibody titers remained positive for longer than 5 years (n=5) than in those titers turned to be negative within 5 years after PTU withdrawal (n=3) (203 +/- 256 EU and 22 +/- 2 EU, respectively, P=0.04), but there were no significant differences in age, gender, duration of PTU therapy or dosage of PTU.	Propylthiouracil	338-341	myeloperoxidase	Homo sapiens	12-15
19851036-7	2010	Among 5 patients who continued PTU therapy, 2 patients with initially low MPO-ANCA titers turned to having negative antibody.	Propylthiouracil	31-34	myeloperoxidase	Homo sapiens	74-77
19851036-9	2010	The long-term follow-up study suggests that higher MPO-ANCA levels remain positive for years after PTU withdrawal but are rarely associated with vasculitis.	Propylthiouracil	99-102	myeloperoxidase	Homo sapiens	51-54
19774650-1	2010	The pre-equilibrium capillary zone electrophoretic (pre-eq CZE) method to determine association constants of active anionic forms of antithyroid drugs: 6-n-propyl-2-thiouracil (PTU), 6-methyl-2-thiouracil (MTU), 2-thiouracil (TU) with bovine serum albumin (BSA) under physiological pH 7.4 has been developed for the first time.	Propylthiouracil	177-180	albumin	Homo sapiens	242-255
19782709-2	2010	The principal genetic determinants of phenotypic variation in PROP taste sensitivity are alleles of the TAS2R38 gene, which encodes a chemosensory receptor sensitive to thiourea compounds including PROP and phenylthiocarbamide.	Propylthiouracil	62-66	taste 2 receptor member 38	Homo sapiens	104-111
19782709-2	2010	The principal genetic determinants of phenotypic variation in PROP taste sensitivity are alleles of the TAS2R38 gene, which encodes a chemosensory receptor sensitive to thiourea compounds including PROP and phenylthiocarbamide.	Propylthiouracil	198-202	taste 2 receptor member 38	Homo sapiens	104-111
21526716-4	2010	Mice fed a diet of propylthiouracil (PTU, an inhibitor of T3 synthesis) for 2 weeks dramatically reduce aMHC mRNA expression and increase bMHC mRNA levels to high levels, while a subsequent withdrawal of PTU diet for 2 weeks completely reverses the T3-mediated changes in MHC expression.	Propylthiouracil	19-35	myosin, heavy polypeptide 7, cardiac muscle, beta	Mus musculus	138-142
21526716-4	2010	Mice fed a diet of propylthiouracil (PTU, an inhibitor of T3 synthesis) for 2 weeks dramatically reduce aMHC mRNA expression and increase bMHC mRNA levels to high levels, while a subsequent withdrawal of PTU diet for 2 weeks completely reverses the T3-mediated changes in MHC expression.	Propylthiouracil	37-40	myosin, heavy polypeptide 7, cardiac muscle, beta	Mus musculus	138-142
20021662-7	2009	Iodine-deficient and 15 ppm PTU-treatment groups demonstrated significantly lower level of total and phosphorylated ERK1/2 and CREB than the controls on PN14, PN21 and PN28 (P &lt; 0.05, respectively).	Propylthiouracil	28-31	mitogen activated protein kinase 3	Rattus norvegicus	116-122
20021662-7	2009	Iodine-deficient and 15 ppm PTU-treatment groups demonstrated significantly lower level of total and phosphorylated ERK1/2 and CREB than the controls on PN14, PN21 and PN28 (P &lt; 0.05, respectively).	Propylthiouracil	28-31	cAMP responsive element binding protein 1	Rattus norvegicus	127-131
19720542-0	2009	Binding of 6-propyl-2-thiouracil to human serum albumin destabilized by chemical denaturants.	Propylthiouracil	11-32	albumin	Homo sapiens	42-55
19669106-7	2009	We observed a similar reduction in HMW-TPO in CHO-TPO cells cultured in propylthiouracil (10 microM and above).	Propylthiouracil	72-88	thyroid peroxidase	Homo sapiens	39-42
19669106-7	2009	We observed a similar reduction in HMW-TPO in CHO-TPO cells cultured in propylthiouracil (10 microM and above).	Propylthiouracil	72-88	thyroid peroxidase	Homo sapiens	50-53
18717240-1	2008	Propylthiouracil (PTU) can induce anti-myeloperoxidase (MPO-ANCA) positive vasculitis.	Propylthiouracil	0-16	myeloperoxidase	Homo sapiens	39-54
19233274-2	2009	PTU was administered from birth to postnatal day 10 (P10) or P21, leading to decreased neural stem cell/progenitor proliferation in the dentate gyrus, as well as significantly fewer granule cells and reduced hippocampal volume.	Propylthiouracil	0-3	KRAS proto-oncogene, GTPase	Rattus norvegicus	61-64
19233274-5	2009	Quantitative PCR revealed decreased FGF-2, NGF, Wnt3a, and VEGF-A hippocampal expression during PTU treatment, with recovery in adulthood.	Propylthiouracil	96-99	fibroblast growth factor 2	Rattus norvegicus	36-41
19233274-5	2009	Quantitative PCR revealed decreased FGF-2, NGF, Wnt3a, and VEGF-A hippocampal expression during PTU treatment, with recovery in adulthood.	Propylthiouracil	96-99	Wnt family member 3A	Rattus norvegicus	48-53
19233274-5	2009	Quantitative PCR revealed decreased FGF-2, NGF, Wnt3a, and VEGF-A hippocampal expression during PTU treatment, with recovery in adulthood.	Propylthiouracil	96-99	vascular endothelial growth factor A	Rattus norvegicus	59-65
19233274-6	2009	Pro-apoptotic Bax was up-regulated, and anti-apoptotic Bcl-2 was down-regulated, during PTU treatment, both of which were normalized in the adult brain.	Propylthiouracil	88-91	BCL2 associated X, apoptosis regulator	Rattus norvegicus	14-17
19233274-6	2009	Pro-apoptotic Bax was up-regulated, and anti-apoptotic Bcl-2 was down-regulated, during PTU treatment, both of which were normalized in the adult brain.	Propylthiouracil	88-91	BCL2, apoptosis regulator	Rattus norvegicus	55-60
19022883-6	2009	Feedback within the hypothalamic-pituitary-thyroid axis was impaired in PAM(+/-) mice made hypothyroid using a low iodine/propylthiouracil diet.	Propylthiouracil	122-138	peptidylglycine alpha-amidating monooxygenase	Mus musculus	72-75
19260531-0	2009	[A case of MPO-ANCA positive vasculitis associated with multiple pulmonary nodules following propylthiouracil treatment].	Propylthiouracil	93-109	myeloperoxidase	Homo sapiens	11-14
19260531-8	2009	The case of MPO-ANCA positive vasculitis associated with multiple pulmonary nodules following propylthiouracil treatment is very rare.	Propylthiouracil	94-110	myeloperoxidase	Homo sapiens	12-15
18339710-8	2008	These reactions were completely inhibited by the Dio1-specific inhibitor 6n-propyl-2-thiouracil (PTU).	Propylthiouracil	73-95	iodothyronine deiodinase 1	Homo sapiens	49-53
18339710-8	2008	These reactions were completely inhibited by the Dio1-specific inhibitor 6n-propyl-2-thiouracil (PTU).	Propylthiouracil	97-100	iodothyronine deiodinase 1	Homo sapiens	49-53
18339710-9	2008	Dio2 containing preparations also deiodinated rT(3)AM and 3",5"-T2AM at the phenolic rings but in a PTU-insensitive fashion.	Propylthiouracil	100-103	iodothyronine deiodinase 2	Homo sapiens	0-4
18334584-0	2008	Beneficial effects of propylthiouracil plus L-thyroxine treatment in a patient with a mutation in MCT8.	Propylthiouracil	22-38	solute carrier family 16 member 2	Homo sapiens	98-102
19520777-8	2009	In rats with hypothyroidism induced by thyroidectomy and 6-propyl-2-thiouracil treatment, the expression of CAR and CYP2B1 was strongly repressed.	Propylthiouracil	57-78	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	108-111
19520777-8	2009	In rats with hypothyroidism induced by thyroidectomy and 6-propyl-2-thiouracil treatment, the expression of CAR and CYP2B1 was strongly repressed.	Propylthiouracil	57-78	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	116-122
19124011-0	2009	Perinatal exposure to PTU decreases expression of Arc, Homer 1, Egr 1 and Kcna 1 in the rat cerebral cortex and hippocampus.	Propylthiouracil	22-25	homer scaffold protein 1	Rattus norvegicus	55-62
19124011-0	2009	Perinatal exposure to PTU decreases expression of Arc, Homer 1, Egr 1 and Kcna 1 in the rat cerebral cortex and hippocampus.	Propylthiouracil	22-25	early growth response 1	Rattus norvegicus	64-69
19124011-0	2009	Perinatal exposure to PTU decreases expression of Arc, Homer 1, Egr 1 and Kcna 1 in the rat cerebral cortex and hippocampus.	Propylthiouracil	22-25	potassium voltage-gated channel subfamily A member 1	Rattus norvegicus	74-80
19301200-2	2009	Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that withdrawal of PTU resulted in clinical remission and significant decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA.	Propylthiouracil	24-40	myeloperoxidase	Homo sapiens	177-192
19301200-2	2009	Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that withdrawal of PTU resulted in clinical remission and significant decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA.	Propylthiouracil	24-40	myeloperoxidase	Homo sapiens	194-197
19301200-2	2009	Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that withdrawal of PTU resulted in clinical remission and significant decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA.	Propylthiouracil	42-45	myeloperoxidase	Homo sapiens	177-192
19301200-2	2009	Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that withdrawal of PTU resulted in clinical remission and significant decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA.	Propylthiouracil	42-45	myeloperoxidase	Homo sapiens	194-197
19301200-2	2009	Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that withdrawal of PTU resulted in clinical remission and significant decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA.	Propylthiouracil	91-94	myeloperoxidase	Homo sapiens	177-192
19301200-2	2009	Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that withdrawal of PTU resulted in clinical remission and significant decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA.	Propylthiouracil	91-94	myeloperoxidase	Homo sapiens	194-197
19335842-1	2009	A recent development in the field of vasculitis is the increasing recognition that certain medications such as propylthiouracil can induce anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV).	Propylthiouracil	111-127	adeno-associated virus integration site 1	Homo sapiens	208-211
18838505-6	2009	alpha-Lipoic acid and 6-propyl-2-thiouracil were evaluated for selectivity of inhibition of CPR and b(5)R activities, respectively, using recombinant enzymes and HLMs, as well as for effects on CYP3A-mediated triazolam hydroxylation in HLMs with either NADH or beta-NADPH.	Propylthiouracil	22-43	cytochrome p450 oxidoreductase	Homo sapiens	92-95
20484932-1	2009	BACKGROUND/AIMS: TAS2R38 belongs to the TAS2R bitter taste receptor gene family and polymorphisms are associated with differences in bitter taste perception of phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).	Propylthiouracil	190-210	taste 2 receptor member 38	Homo sapiens	17-24
20484932-1	2009	BACKGROUND/AIMS: TAS2R38 belongs to the TAS2R bitter taste receptor gene family and polymorphisms are associated with differences in bitter taste perception of phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).	Propylthiouracil	212-216	taste 2 receptor member 38	Homo sapiens	17-24
18719631-1	2008	OBJECTIVE: Variation in the bitter-taste receptor gene, TAS2R38 confers the ability to taste 6-n-propylthiouracil (PROP).	Propylthiouracil	93-113	taste 2 receptor member 38	Homo sapiens	56-63
18719631-1	2008	OBJECTIVE: Variation in the bitter-taste receptor gene, TAS2R38 confers the ability to taste 6-n-propylthiouracil (PROP).	Propylthiouracil	115-119	taste 2 receptor member 38	Homo sapiens	56-63
18334584-14	2008	CONCLUSIONS: 1) When thyroid hormone production was reduced by PTU, high doses of LT(4) (3.7 microg/kg.d) were needed to normalize serum TSH, confirming that mutation of MCT8 is a cause of resistance to thyroid hormone.	Propylthiouracil	63-66	solute carrier family 16 member 2	Homo sapiens	170-174
18717240-1	2008	Propylthiouracil (PTU) can induce anti-myeloperoxidase (MPO-ANCA) positive vasculitis.	Propylthiouracil	0-16	myeloperoxidase	Homo sapiens	56-59
18717240-1	2008	Propylthiouracil (PTU) can induce anti-myeloperoxidase (MPO-ANCA) positive vasculitis.	Propylthiouracil	18-21	myeloperoxidase	Homo sapiens	39-54
18717240-1	2008	Propylthiouracil (PTU) can induce anti-myeloperoxidase (MPO-ANCA) positive vasculitis.	Propylthiouracil	18-21	myeloperoxidase	Homo sapiens	56-59
18717240-10	2008	PTU was discontinued in patients with vasculitis and positive for MPO-ANCA.	Propylthiouracil	0-3	myeloperoxidase	Homo sapiens	66-69
18717240-11	2008	Our findings show a high prevalence of MPO-ANCA positivity and a significantly higher percentage of vasculitis among these patients, suggesting that patients taking PTU should be closely observed for the appearance of MPO-ANCA and signs of vasculitis, especially patients GD who have been treated for a long time.	Propylthiouracil	165-168	myeloperoxidase	Homo sapiens	39-42
18717240-11	2008	Our findings show a high prevalence of MPO-ANCA positivity and a significantly higher percentage of vasculitis among these patients, suggesting that patients taking PTU should be closely observed for the appearance of MPO-ANCA and signs of vasculitis, especially patients GD who have been treated for a long time.	Propylthiouracil	165-168	myeloperoxidase	Homo sapiens	218-221
17611791-0	2008	Propylthiouracil induced C-ANCA positive agranulocytosis complicating Graves" thyrotoxicosis in pregnancy.	Propylthiouracil	0-16	proteinase 3	Homo sapiens	25-31
18192211-4	2008	PTU treatment made animals hypothyroid and that resulted in total replacement of cardiac alpha-MHC with the beta-MHC isoform.	Propylthiouracil	0-3	myosin, heavy polypeptide 6, cardiac muscle, alpha	Mus musculus	89-98
18192211-4	2008	PTU treatment made animals hypothyroid and that resulted in total replacement of cardiac alpha-MHC with the beta-MHC isoform.	Propylthiouracil	0-3	myosin, heavy polypeptide 7, cardiac muscle, beta	Mus musculus	108-116
18192211-5	2008	Addition of fructose in the PTU diet led to reexpression of the alpha-MHC isoform to a significant level.	Propylthiouracil	28-31	myosin, heavy polypeptide 6, cardiac muscle, alpha	Mus musculus	64-73
18192211-6	2008	Similar induction of alpha-MHC expression was also seen when PTU diet was combined with resveratrol, an agonist of sirtuin (SIRT) 1 deacetylase.	Propylthiouracil	61-64	myosin, heavy polypeptide 6, cardiac muscle, alpha	Mus musculus	21-30
18055877-6	2008	Carbimazole inhibited NF-kappaB via the small GTPase Rac-1, whereas propylthiouracil inhibited the phosphorylation of IkappaBalpha by its kinase inhibitor of kappaB kinase alpha.	Propylthiouracil	68-84	NFKB inhibitor alpha	Homo sapiens	118-130
18390212-0	2008	[The expression rule of proliferating cell nuclear antigen in rat thyroid of hyperplasia induced by propylthiouracil].	Propylthiouracil	100-116	proliferating cell nuclear antigen	Rattus norvegicus	24-58
18316471-0	2008	Propylthiouracil-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis.	Propylthiouracil	0-16	vimentin	Rattus norvegicus	63-71
18390212-1	2008	OBJECTIVE: To study the expression rule of proliferating cell nuclear antigen (PCNA) in thyroid when the hyperplasia of male rat thyroid is induced by propylthiouracil (PTU).	Propylthiouracil	151-167	proliferating cell nuclear antigen	Rattus norvegicus	43-77
18390212-1	2008	OBJECTIVE: To study the expression rule of proliferating cell nuclear antigen (PCNA) in thyroid when the hyperplasia of male rat thyroid is induced by propylthiouracil (PTU).	Propylthiouracil	151-167	proliferating cell nuclear antigen	Rattus norvegicus	79-83
18390212-1	2008	OBJECTIVE: To study the expression rule of proliferating cell nuclear antigen (PCNA) in thyroid when the hyperplasia of male rat thyroid is induced by propylthiouracil (PTU).	Propylthiouracil	169-172	proliferating cell nuclear antigen	Rattus norvegicus	43-77
18390212-1	2008	OBJECTIVE: To study the expression rule of proliferating cell nuclear antigen (PCNA) in thyroid when the hyperplasia of male rat thyroid is induced by propylthiouracil (PTU).	Propylthiouracil	169-172	proliferating cell nuclear antigen	Rattus norvegicus	79-83
18390212-4	2008	RESULTS: Compared with the control group, the PCNA level in the thyroid of rats given PTU for 3 days significantly increased (P &lt; 0.05),and reached the highest expression when it was 6 days, but then when it was 9 days and 12 days, the PCNA expression showed a descending tendency.	Propylthiouracil	86-89	proliferating cell nuclear antigen	Rattus norvegicus	46-50
18390212-4	2008	RESULTS: Compared with the control group, the PCNA level in the thyroid of rats given PTU for 3 days significantly increased (P &lt; 0.05),and reached the highest expression when it was 6 days, but then when it was 9 days and 12 days, the PCNA expression showed a descending tendency.	Propylthiouracil	86-89	proliferating cell nuclear antigen	Rattus norvegicus	239-243
18044264-0	2007	Analysis of MPO-ANCA subtypes in a patient with propylthiouracil-induced vasculitis with multiple complications.	Propylthiouracil	48-64	myeloperoxidase	Homo sapiens	12-15