PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20128807-0	2010	SZ-685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway.	SZ 685C	0-7	AKT serine/threonine kinase 1	Homo sapiens	113-116
20128807-3	2010	SZ-685C-induced apoptosis was assessed by Annexin V-fluorescein isothiocyanate/propidium iodide staining, terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay and analysis of caspase activation.	SZ 685C	0-7	annexin A5	Homo sapiens	42-51
20128807-6	2010	SZ-685C had a direct apoptosis-inducing effect through both the extrinsic and intrinsic apoptotic pathways, as shown by activation of caspase-8 and 9 as well as effector caspase-3 and poly (ADP-ribose) polymerase.	SZ 685C	0-7	caspase 8	Homo sapiens	134-143
20128807-6	2010	SZ-685C had a direct apoptosis-inducing effect through both the extrinsic and intrinsic apoptotic pathways, as shown by activation of caspase-8 and 9 as well as effector caspase-3 and poly (ADP-ribose) polymerase.	SZ 685C	0-7	caspase 3	Homo sapiens	170-212
20128807-8	2010	Furthermore, the pro-apoptotic protein Bim was up-regulated by SZ-685C treatment consistent with FOXO dephosphorylation.	SZ 685C	63-70	BCL2 like 11	Homo sapiens	39-42
20128807-9	2010	CONCLUSIONS AND IMPLICATIONS: SZ-685C could induce apoptosis through the Akt/FOXO pathway, which consequently leads to the observed anti-tumour effect both in vitro and in vivo.	SZ 685C	30-37	AKT serine/threonine kinase 1	Homo sapiens	73-76
20128807-10	2010	Our data suggest that SZ-685C may be a potentially promising Akt inhibitor and anti-cancer drug candidate.	SZ 685C	22-29	AKT serine/threonine kinase 1	Homo sapiens	61-64
23564023-0	2013	SZ-685C exhibits potent anticancer activity in both radiosensitive and radioresistant NPC cells through the miR-205-PTEN-Akt pathway.	SZ 685C	0-7	microRNA 205	Homo sapiens	108-115
25806467-0	2015	The marine metabolite SZ-685C induces apoptosis in primary human nonfunctioning pituitary adenoma cells by inhibition of the Akt pathway in vitro.	SZ 685C	22-29	AKT serine/threonine kinase 1	Homo sapiens	125-128
25806467-9	2015	Notably, the protein expression levels of Akt were decreased when the primary human NFPA cells were treated with SZ-685C.	SZ 685C	113-120	AKT serine/threonine kinase 1	Homo sapiens	42-45
25806467-10	2015	Here, we show that SZ-685C induces apoptosis of human NFPA cells through inhibition of the Akt pathway in vitro.	SZ 685C	19-26	AKT serine/threonine kinase 1	Homo sapiens	91-94
23564023-0	2013	SZ-685C exhibits potent anticancer activity in both radiosensitive and radioresistant NPC cells through the miR-205-PTEN-Akt pathway.	SZ 685C	0-7	phosphatase and tensin homolog	Homo sapiens	116-120
23564023-0	2013	SZ-685C exhibits potent anticancer activity in both radiosensitive and radioresistant NPC cells through the miR-205-PTEN-Akt pathway.	SZ 685C	0-7	AKT serine/threonine kinase 1	Homo sapiens	121-124
23564023-5	2013	SZ-685C was expected to abrogate the radioresistance of CNE2 cells through the miR-205-PTEN-Akt pathway.	SZ 685C	0-7	microRNA 205	Homo sapiens	79-86
23564023-5	2013	SZ-685C was expected to abrogate the radioresistance of CNE2 cells through the miR-205-PTEN-Akt pathway.	SZ 685C	0-7	phosphatase and tensin homolog	Homo sapiens	87-91
23564023-5	2013	SZ-685C was expected to abrogate the radioresistance of CNE2 cells through the miR-205-PTEN-Akt pathway.	SZ 685C	0-7	AKT serine/threonine kinase 1	Homo sapiens	92-95
22690138-0	2012	A marine anthraquinone SZ-685C overrides adriamycin-resistance in breast cancer cells through suppressing Akt signaling.	SZ 685C	23-30	AKT serine/threonine kinase 1	Homo sapiens	106-109
23317100-0	2013	A novel marine drug, SZ-685C, induces apoptosis of MMQ pituitary tumor cells by downregulating miR-200c.	SZ 685C	21-28	microRNA 200c	Rattus norvegicus	95-103
23317100-16	2013	Furthermore, the overexpression of miR-200c weakened the effect of SZ-685C-induced apoptosis of MMQ cells.	SZ 685C	67-74	microRNA 200c	Rattus norvegicus	35-43
23317100-17	2013	CONCLUSIONS: Our results suggest that SZ-685C induces MMQ cell apoptosis in a miR-200c-dependent manner.	SZ 685C	38-45	microRNA 200c	Rattus norvegicus	78-86
22690138-5	2012	In this context, SZ-685C, an agent that has been previously shown, as such, to suppress Akt signaling, is expected to increase the efficacy of chemotherapy.	SZ 685C	17-24	AKT serine/threonine kinase 1	Homo sapiens	88-91
22690138-6	2012	Our current study investigated whether SZ-685C can override chemoresistance through inhibiting Akt signaling in human breast cancer cells.	SZ 685C	39-46	AKT serine/threonine kinase 1	Homo sapiens	95-98
22690138-8	2012	We found that SZ-685C suppressed the Akt pathway and induced apoptosis in MCF-7/ADR and MCF-7/Akt cells that are resistant to ADR treatment, leading to antitumor effects both in vitro and in vivo.	SZ 685C	14-21	AKT serine/threonine kinase 1	Homo sapiens	37-40
22690138-8	2012	We found that SZ-685C suppressed the Akt pathway and induced apoptosis in MCF-7/ADR and MCF-7/Akt cells that are resistant to ADR treatment, leading to antitumor effects both in vitro and in vivo.	SZ 685C	14-21	AKT serine/threonine kinase 1	Homo sapiens	94-97