PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
10913616-0	2000	Flavones and flavonols at dietary levels inhibit a transformation of aryl hydrocarbon receptor induced by dioxin.	Flavonols	13-22	aryl hydrocarbon receptor	Homo sapiens	69-94
11950788-11	2002	In contrast, all tested 5,7-dihydroxyflavones and -flavonols induced CYP1A1 activity (ethoxyresorufin deethylation).	Flavonols	51-60	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	69-75
11409965-2	2001	From seven structurally divergent groups of flavonoids, only flavonols with a free hydroxyl group at the C-3 position of the flavonoid skeleton showed high inhibitory activity to beta-carotene oxidation.	Flavonols	61-70	complement C3	Homo sapiens	105-108
11105561-2	2000	Besides their antioxidative properties and effects on the arachidonic acid metabolism including cyclooxygenase/lipoxygenase inhibition, some flavones and flavonols were previously found to show inhibitory activity on nitric oxide production by inducible nitric oxide synthase (iNOS; NOS type 2) through suppression of iNOS induction.	Flavonols	154-163	nitric oxide synthase 2, inducible	Mus musculus	244-275
11105561-2	2000	Besides their antioxidative properties and effects on the arachidonic acid metabolism including cyclooxygenase/lipoxygenase inhibition, some flavones and flavonols were previously found to show inhibitory activity on nitric oxide production by inducible nitric oxide synthase (iNOS; NOS type 2) through suppression of iNOS induction.	Flavonols	154-163	nitric oxide synthase 2, inducible	Mus musculus	277-281
11105561-2	2000	Besides their antioxidative properties and effects on the arachidonic acid metabolism including cyclooxygenase/lipoxygenase inhibition, some flavones and flavonols were previously found to show inhibitory activity on nitric oxide production by inducible nitric oxide synthase (iNOS; NOS type 2) through suppression of iNOS induction.	Flavonols	154-163	nitric oxide synthase 2, inducible	Mus musculus	318-322
11792676-2	2002	In this study, we used human liver microsomes and recombinant P450 isoforms to examine the metabolism of two flavonols, galangin and kaempferide, and one flavone, chrysin.	Flavonols	109-118	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	62-66
11792676-6	2002	In addition, CYP1A1, although less efficient, was also able to oxidize the two flavonols.	Flavonols	79-88	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	13-19
10913616-3	2000	We examined flavonoids ubiquitously expressed in plant foods as one of the best candidates, and found that the subclasses flavones and flavonols suppressed antagonistically the transformation of AhR induced by 1 nM of 2,3,7,8-tetrachlorodibenzo-p-dioxin, without exhibiting agonistic effects that transform AhR.	Flavonols	135-144	aryl hydrocarbon receptor	Homo sapiens	195-198
10913616-3	2000	We examined flavonoids ubiquitously expressed in plant foods as one of the best candidates, and found that the subclasses flavones and flavonols suppressed antagonistically the transformation of AhR induced by 1 nM of 2,3,7,8-tetrachlorodibenzo-p-dioxin, without exhibiting agonistic effects that transform AhR.	Flavonols	135-144	aryl hydrocarbon receptor	Homo sapiens	307-310
10976523-0	2000	Flavonols from Heterotheca inuloides: tyrosinase inhibitory activity and structural criteria.	Flavonols	0-9	tyrosinase	Homo sapiens	38-48
10976523-1	2000	Tyrosinase inhibitory activity of flavonols, galangin, kaempferol and quercetin, was found to come from their ability to chelate copper in the enzyme.	Flavonols	34-43	tyrosinase	Homo sapiens	0-10
10864017-9	2000	Flavonols, such as quercetin and kaempferol, inhibited the P-ST activity at low concentrations.	Flavonols	0-9	sulfotransferase family 1A member 1	Homo sapiens	59-63
11216487-6	2000	As the results, flavones and flavonols at dietary levels act as the antagonists for AhR and suppress the transformation.	Flavonols	29-38	aryl hydrocarbon receptor	Homo sapiens	84-87
9461039-7	1997	The data show that, of the flavonoids, the flavonols are the most effective inducers of quinone reductase activity in Hepa1c1c7 cells (kaempferol approximately galangin > quercetin > myricetin approximately apigenin (a flavone)) and that flavanols and flavans are ineffective.	Flavonols	43-52	crystallin, zeta	Mus musculus	88-105
9492341-4	1998	We found that naringenin, a flavanone, and quercetin and kaempferol, flavonols, inhibit estrogen binding to AFP with apparent Kds of about 5 x 10(-7) M. To our surprise, the two isoflavonoids, daidzein and genistein, have Kds of about 5 x 10(-6) M for AFP.	Flavonols	69-78	alpha-fetoprotein	Rattus norvegicus	108-111
10359656-0	1999	Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially.	Flavonols	8-17	aryl hydrocarbon receptor	Homo sapiens	62-87
10359656-0	1999	Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially.	Flavonols	8-17	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	100-106
10359656-13	1999	These results demonstrate that the dietary flavonols quercetin and kaempferol are natural, dietary ligands of the AhR that exert different effects on CYP1A1 transcription.	Flavonols	43-52	aryl hydrocarbon receptor	Homo sapiens	114-117
10359656-13	1999	These results demonstrate that the dietary flavonols quercetin and kaempferol are natural, dietary ligands of the AhR that exert different effects on CYP1A1 transcription.	Flavonols	43-52	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	150-156
9025306-5	1997	Fls gene expression was detected in pistils, anthers, petals and ovaries, the organs in which flavonols are accumulating.	Flavonols	94-103	flavonol synthase/flavanone 3-hydroxylase	Solanum tuberosum	0-3
7673925-3	1995	Flavones and flavonols exhibited a strong inhibitory effect on trypsin; the presence of hydroxyl groups at positions C-5 and C-7 in ring A is necessary for inhibition of the enzyme, while the simultaneous presence of free hydroxyl groups at positions C-3" and C-4" enhances the inhibitory activity.	Flavonols	13-22	complement C5	Homo sapiens	117-120
8720382-1	1996	Flavonols like quercetin, myricetin, and kaempferol inhibit the activity of the adenosine deaminase of endothelial cells (IC50 between 26 and 32 mumol/l), while flavones are inactive.	Flavonols	0-9	adenosine deaminase	Homo sapiens	80-99
7673925-3	1995	Flavones and flavonols exhibited a strong inhibitory effect on trypsin; the presence of hydroxyl groups at positions C-5 and C-7 in ring A is necessary for inhibition of the enzyme, while the simultaneous presence of free hydroxyl groups at positions C-3" and C-4" enhances the inhibitory activity.	Flavonols	13-22	complement C7	Homo sapiens	125-128
7673925-3	1995	Flavones and flavonols exhibited a strong inhibitory effect on trypsin; the presence of hydroxyl groups at positions C-5 and C-7 in ring A is necessary for inhibition of the enzyme, while the simultaneous presence of free hydroxyl groups at positions C-3" and C-4" enhances the inhibitory activity.	Flavonols	13-22	complement C3	Homo sapiens	251-254
7673925-3	1995	Flavones and flavonols exhibited a strong inhibitory effect on trypsin; the presence of hydroxyl groups at positions C-5 and C-7 in ring A is necessary for inhibition of the enzyme, while the simultaneous presence of free hydroxyl groups at positions C-3" and C-4" enhances the inhibitory activity.	Flavonols	13-22	complement C4A (Rodgers blood group)	Homo sapiens	260-263
7550105-6	1995	It is suggested that the inhibitory effect of Buddlejae Flos on aldose reductase is partially attributable to these flavonols or their glycosides.	Flavonols	116-125	aldo-keto reductase family 1 member B1	Rattus norvegicus	64-80
7773305-1	1995	Flavanone 3-hydroxylase (F3H) activity is necessary for the production of both flavonols and anthocyanins.	Flavonols	79-88	Flavanone 3-dioxygenase 1	Zea mays	0-23
7773305-1	1995	Flavanone 3-hydroxylase (F3H) activity is necessary for the production of both flavonols and anthocyanins.	Flavonols	79-88	Flavanone 3-dioxygenase 1	Zea mays	25-28
7773305-7	1995	Slot blot analysis showed that F3H transcript levels in young seedlings are increased by high fluence-rate white light treatment in the presence of the anthocyanin regulatory gene -r. HPLC analysis of extracts from developmentally staged anthers showed that flavonol accumulation begins at the uninucleate microspore stage, continues until maturity, and is not controlled by -r. When the expression pattern of several flavonoid biosynthetic genes was analyzed during microsporogenesis, only F3H transcript accumulation was coordinate with the appearance of flavonols in anthers.	Flavonols	557-566	Flavanone 3-dioxygenase 1	Zea mays	31-34
7475916-0	1995	Effects of flavonols on P-glycoprotein activity in cultured rat hepatocytes.	Flavonols	11-20	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	24-38
7475916-1	1995	The effects of flavonols on P-glycoprotein (Pgp) activity were studied in cultured rat hepatocytes by assessing and transmembrane transport of Rhodamine-123 (R-123) and doxorubicin (DOX).	Flavonols	15-24	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	28-42
7475916-1	1995	The effects of flavonols on P-glycoprotein (Pgp) activity were studied in cultured rat hepatocytes by assessing and transmembrane transport of Rhodamine-123 (R-123) and doxorubicin (DOX).	Flavonols	15-24	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	44-47
7475916-2	1995	In freshly-plated hepatocytes, containing a low amount of Pgp, flavonols did not affect the cellular retention of DOX, but strongly inhibited the Pgp-mediated efflux of R-123.	Flavonols	63-72	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	58-61
7475916-2	1995	In freshly-plated hepatocytes, containing a low amount of Pgp, flavonols did not affect the cellular retention of DOX, but strongly inhibited the Pgp-mediated efflux of R-123.	Flavonols	63-72	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	146-149
7475916-3	1995	In 72h-cultured hepatocytes, spontaneously overexpressing functional Pgp, flavonols inhibited R-123 efflux in a dose-dependent manner, but significantly reduced DOX retention while increasing its efflux.	Flavonols	74-83	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	69-72
7475916-5	1995	These findings indicate that flavonols, dietary compounds reported to strongly upregulate the apparent activity of Pgp in cancer cell lines, may also modulate differently the transport of putative Pgp substrates in normal rat hepatocytes.	Flavonols	29-38	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	115-118
7475916-5	1995	These findings indicate that flavonols, dietary compounds reported to strongly upregulate the apparent activity of Pgp in cancer cell lines, may also modulate differently the transport of putative Pgp substrates in normal rat hepatocytes.	Flavonols	29-38	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	197-200
7857510-4	1994	The MAO inhibiting fraction contained hypericins as well as flavonols, the COMT-inhibition fraction being mainly flavonols and xanthones.	Flavonols	113-122	catechol-O-methyltransferase	Homo sapiens	75-79
7903198-4	1993	In our attempt to find naturally occurring dietary compounds which may stimulate the P-gp-mediated efflux of carcinogens, we found that certain flavonols, kaempferol, quercetin, and galangin, are potent stimulators of the P-gp-mediated efflux of 7,12-dimethylbenz(a)-anthracene.	Flavonols	144-153	ATP binding cassette subfamily B member 1	Homo sapiens	85-89
7903198-4	1993	In our attempt to find naturally occurring dietary compounds which may stimulate the P-gp-mediated efflux of carcinogens, we found that certain flavonols, kaempferol, quercetin, and galangin, are potent stimulators of the P-gp-mediated efflux of 7,12-dimethylbenz(a)-anthracene.	Flavonols	144-153	ATP binding cassette subfamily B member 1	Homo sapiens	222-226
11607312-0	1992	Biochemical complementation of chalcone synthase mutants defines a role for flavonols in functional pollen.	Flavonols	76-85	chalcone synthase	Zea mays	31-48
7480205-3	1995	It can be supposed that the main effect of the tested flavonols is based on their inhibition of myeloperoxidase, besides inhibition of enzymes involved in activating the NADPH-oxidase, and a direct reaction with oxygen radicals.	Flavonols	54-63	myeloperoxidase	Homo sapiens	96-111
33588278-2	2021	Whithin this field sixteen novel Co(III) ternary complexes with the general formula [Co(4N)(flav)](ClO4)2, where 4N = tris(2-aminoethyl)amine (tren) or tris(2-pyridylmethyl)amine (tpa) and flav = deprotonated form of differently substituted flavonols have been synthesized, characterized, and their cytotoxicity assayed under both normoxic and hypoxic conditions.	Flavonols	241-250	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	33-40
34803449-0	2021	Determination of the interaction between the receptor binding domain of 2019-nCoV spike protein, TMPRSS2, cathepsin B and cathepsin L, and glycosidic and aglycon forms of some flavonols.	Flavonols	176-185	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	82-87
34659296-5	2021	According to the significant changes in gene expression encoding auxin transport carriers and their correlation with flavonols during stage 5, the flavonols were speculated to have a direct inhibitory effect on the expression of PIN4 encoding gene, which may inhibit the process of polar auxin transport.	Flavonols	117-126	peptidylprolyl cis/trans isomerase, NIMA-interacting 4	Homo sapiens	229-233
34659296-5	2021	According to the significant changes in gene expression encoding auxin transport carriers and their correlation with flavonols during stage 5, the flavonols were speculated to have a direct inhibitory effect on the expression of PIN4 encoding gene, which may inhibit the process of polar auxin transport.	Flavonols	147-156	peptidylprolyl cis/trans isomerase, NIMA-interacting 4	Homo sapiens	229-233
34638702-12	2021	Inhibition of the PI3-K/Akt pathway abolished the neuroprotective effect of the investigated flavonols.	Flavonols	93-102	AKT serine/threonine kinase 1	Homo sapiens	24-27
33770716-9	2021	Our results shown that the ectopic PAP1 expression led to significant accumulation of cyanidin-type anthocyanins, quercetin-type flavonols and hydroxycinnamic acids and their glycosylated derivatives.	Flavonols	129-138	phosphatidic acid phosphatase 1	Arabidopsis thaliana	35-39
34946578-4	2021	The flavonols could decrease the production of prostaglandin E2 and three pro-inflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha, and simultaneously promote the production of two anti-inflammatory cytokines IL-10 and transforming growth factor-beta.	Flavonols	4-13	interleukin 1 beta	Rattus norvegicus	101-118
34946578-4	2021	The flavonols could decrease the production of prostaglandin E2 and three pro-inflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha, and simultaneously promote the production of two anti-inflammatory cytokines IL-10 and transforming growth factor-beta.	Flavonols	4-13	interleukin 1 alpha	Rattus norvegicus	120-128
34946578-4	2021	The flavonols could decrease the production of prostaglandin E2 and three pro-inflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha, and simultaneously promote the production of two anti-inflammatory cytokines IL-10 and transforming growth factor-beta.	Flavonols	4-13	interleukin 6	Rattus norvegicus	131-135
34946578-4	2021	The flavonols could decrease the production of prostaglandin E2 and three pro-inflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha, and simultaneously promote the production of two anti-inflammatory cytokines IL-10 and transforming growth factor-beta.	Flavonols	4-13	tumor necrosis factor	Rattus norvegicus	141-168
34946578-4	2021	The flavonols could decrease the production of prostaglandin E2 and three pro-inflammatory cytokines interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha, and simultaneously promote the production of two anti-inflammatory cytokines IL-10 and transforming growth factor-beta.	Flavonols	4-13	interleukin 10	Rattus norvegicus	247-252
34946578-5	2021	The Western-blot results verified that the flavonols could suppress the LPS-induced expression of TLR4 and phosphorylated IkappaBalpha and p65, while the molecular docking results also illustrated that the flavonols could bind with TLR4 and NF-kappaB to yield energy decreases of -(21.9-28.6) kJ/mol.	Flavonols	43-52	toll-like receptor 4	Rattus norvegicus	98-102
34946578-5	2021	The Western-blot results verified that the flavonols could suppress the LPS-induced expression of TLR4 and phosphorylated IkappaBalpha and p65, while the molecular docking results also illustrated that the flavonols could bind with TLR4 and NF-kappaB to yield energy decreases of -(21.9-28.6) kJ/mol.	Flavonols	43-52	NFKB inhibitor alpha	Rattus norvegicus	122-134
34946578-5	2021	The Western-blot results verified that the flavonols could suppress the LPS-induced expression of TLR4 and phosphorylated IkappaBalpha and p65, while the molecular docking results also illustrated that the flavonols could bind with TLR4 and NF-kappaB to yield energy decreases of -(21.9-28.6) kJ/mol.	Flavonols	43-52	synaptotagmin 1	Rattus norvegicus	139-142
34946578-5	2021	The Western-blot results verified that the flavonols could suppress the LPS-induced expression of TLR4 and phosphorylated IkappaBalpha and p65, while the molecular docking results also illustrated that the flavonols could bind with TLR4 and NF-kappaB to yield energy decreases of -(21.9-28.6) kJ/mol.	Flavonols	43-52	toll-like receptor 4	Rattus norvegicus	232-236
34946578-5	2021	The Western-blot results verified that the flavonols could suppress the LPS-induced expression of TLR4 and phosphorylated IkappaBalpha and p65, while the molecular docking results also illustrated that the flavonols could bind with TLR4 and NF-kappaB to yield energy decreases of -(21.9-28.6) kJ/mol.	Flavonols	206-215	toll-like receptor 4	Rattus norvegicus	98-102
34946578-5	2021	The Western-blot results verified that the flavonols could suppress the LPS-induced expression of TLR4 and phosphorylated IkappaBalpha and p65, while the molecular docking results also illustrated that the flavonols could bind with TLR4 and NF-kappaB to yield energy decreases of -(21.9-28.6) kJ/mol.	Flavonols	206-215	NFKB inhibitor alpha	Rattus norvegicus	122-134
34946578-5	2021	The Western-blot results verified that the flavonols could suppress the LPS-induced expression of TLR4 and phosphorylated IkappaBalpha and p65, while the molecular docking results also illustrated that the flavonols could bind with TLR4 and NF-kappaB to yield energy decreases of -(21.9-28.6) kJ/mol.	Flavonols	206-215	synaptotagmin 1	Rattus norvegicus	139-142
34946578-5	2021	The Western-blot results verified that the flavonols could suppress the LPS-induced expression of TLR4 and phosphorylated IkappaBalpha and p65, while the molecular docking results also illustrated that the flavonols could bind with TLR4 and NF-kappaB to yield energy decreases of -(21.9-28.6) kJ/mol.	Flavonols	206-215	toll-like receptor 4	Rattus norvegicus	232-236
34946578-6	2021	Furthermore, an inhibitor BAY 11-7082 blocked the NF-kappaB signaling pathway by inhibiting the expression of phosphorylated IkappaBalpha/p65 and thus mediated the production of IL-6/IL-10 as the flavonols did, which confirmed the assessed anti-inflammatory effect of the flavonols.	Flavonols	196-205	interleukin 6	Rattus norvegicus	178-182
34946578-6	2021	Furthermore, an inhibitor BAY 11-7082 blocked the NF-kappaB signaling pathway by inhibiting the expression of phosphorylated IkappaBalpha/p65 and thus mediated the production of IL-6/IL-10 as the flavonols did, which confirmed the assessed anti-inflammatory effect of the flavonols.	Flavonols	196-205	interleukin 10	Rattus norvegicus	183-188
34946578-6	2021	Furthermore, an inhibitor BAY 11-7082 blocked the NF-kappaB signaling pathway by inhibiting the expression of phosphorylated IkappaBalpha/p65 and thus mediated the production of IL-6/IL-10 as the flavonols did, which confirmed the assessed anti-inflammatory effect of the flavonols.	Flavonols	272-281	NFKB inhibitor alpha	Rattus norvegicus	125-137
34946578-6	2021	Furthermore, an inhibitor BAY 11-7082 blocked the NF-kappaB signaling pathway by inhibiting the expression of phosphorylated IkappaBalpha/p65 and thus mediated the production of IL-6/IL-10 as the flavonols did, which confirmed the assessed anti-inflammatory effect of the flavonols.	Flavonols	272-281	synaptotagmin 1	Rattus norvegicus	138-141
34946578-6	2021	Furthermore, an inhibitor BAY 11-7082 blocked the NF-kappaB signaling pathway by inhibiting the expression of phosphorylated IkappaBalpha/p65 and thus mediated the production of IL-6/IL-10 as the flavonols did, which confirmed the assessed anti-inflammatory effect of the flavonols.	Flavonols	272-281	interleukin 6	Rattus norvegicus	178-182
34946578-6	2021	Furthermore, an inhibitor BAY 11-7082 blocked the NF-kappaB signaling pathway by inhibiting the expression of phosphorylated IkappaBalpha/p65 and thus mediated the production of IL-6/IL-10 as the flavonols did, which confirmed the assessed anti-inflammatory effect of the flavonols.	Flavonols	272-281	interleukin 10	Rattus norvegicus	183-188
34946578-8	2021	It is highlighted that the flavonols could antagonize the LPS-caused IEC-6 cells inflammation via suppressing TLR4/NF-kappaB activation, but heat treatment of the flavonols led to reduced anti-inflammatory efficacy.	Flavonols	27-36	toll-like receptor 4	Rattus norvegicus	110-114
34679762-0	2021	Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-kappaB and p53 Pathways in Neurodegeneration.	Flavonols	64-73	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
34679762-0	2021	Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-kappaB and p53 Pathways in Neurodegeneration.	Flavonols	64-73	nuclear factor kappa B subunit 1	Homo sapiens	91-100
34679762-0	2021	Anti-Oxidative, Anti-Inflammatory and Anti-Apoptotic Effects of Flavonols: Targeting Nrf2, NF-kappaB and p53 Pathways in Neurodegeneration.	Flavonols	64-73	tumor protein p53	Homo sapiens	105-108
34679762-7	2021	Herein, we review the current understanding of the therapeutic potential and limitations of flavonols in neuroprotection, with emphasis on their anti-oxidative, anti-inflammatory and anti-apoptotic effects along the Nrf2, NF-kappaB and p53 pathways.	Flavonols	92-101	NFE2 like bZIP transcription factor 2	Homo sapiens	216-220
34679762-7	2021	Herein, we review the current understanding of the therapeutic potential and limitations of flavonols in neuroprotection, with emphasis on their anti-oxidative, anti-inflammatory and anti-apoptotic effects along the Nrf2, NF-kappaB and p53 pathways.	Flavonols	92-101	nuclear factor kappa B subunit 1	Homo sapiens	222-231
34679762-7	2021	Herein, we review the current understanding of the therapeutic potential and limitations of flavonols in neuroprotection, with emphasis on their anti-oxidative, anti-inflammatory and anti-apoptotic effects along the Nrf2, NF-kappaB and p53 pathways.	Flavonols	92-101	tumor protein p53	Homo sapiens	236-239
34803449-2	2021	In this research, the interactions between specific flavonols and the 2019-nCoV receptor binding domain (RBD), transmembrane protease, serine 2 (TMPRSS2), and cathepsins (CatB and CatL) were analyzed.	Flavonols	52-61	cathepsin B	Homo sapiens	171-175
34803449-2	2021	In this research, the interactions between specific flavonols and the 2019-nCoV receptor binding domain (RBD), transmembrane protease, serine 2 (TMPRSS2), and cathepsins (CatB and CatL) were analyzed.	Flavonols	52-61	cathepsin L	Homo sapiens	180-184
34151085-4	2021	Meanwhile, pretreatment of the cells with these flavonols for 24 and 48 h before the indomethacin exposure could alleviate cytotoxicity and especially barrier loss, resulting in increased cell viability and transepithelial resistance, decreased LDH release, ROS production, and paracellular permeability, together with the promoted expression of three tight junction proteins zonula occluden-1, occludin, and claudin-1.	Flavonols	48-57	occludin	Rattus norvegicus	395-403
34177989-8	2021	Our study demonstrated that LaPT2 from white lupin is responsible for the biosynthesis of prenylated flavonoids, in particular flavonols, which could be utilized as phytoalexin for plant defense and bioactive flavonoid compounds for human health.	Flavonols	127-136	5'-nucleotidase, cytosolic IIIA	Homo sapiens	45-50
34151085-5	2021	Moreover, the intracellular Ca2+ concentration and expression levels of p-JNK and p-Src arisen from the indomethacin damage were also reduced by the flavonols, suggesting an inhibited calcium-mediated JNK/Src activation.	Flavonols	149-158	mitogen-activated protein kinase 8	Rattus norvegicus	74-77
34151085-5	2021	Moreover, the intracellular Ca2+ concentration and expression levels of p-JNK and p-Src arisen from the indomethacin damage were also reduced by the flavonols, suggesting an inhibited calcium-mediated JNK/Src activation.	Flavonols	149-158	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	84-87
34151085-5	2021	Moreover, the intracellular Ca2+ concentration and expression levels of p-JNK and p-Src arisen from the indomethacin damage were also reduced by the flavonols, suggesting an inhibited calcium-mediated JNK/Src activation.	Flavonols	149-158	mitogen-activated protein kinase 8	Rattus norvegicus	201-204
34151085-5	2021	Moreover, the intracellular Ca2+ concentration and expression levels of p-JNK and p-Src arisen from the indomethacin damage were also reduced by the flavonols, suggesting an inhibited calcium-mediated JNK/Src activation.	Flavonols	149-158	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	205-208
34065200-6	2021	This effect was attributed to flavonols, which might also account for the ability of RNLE to impair TNF-alpha/IL-4-induced TSLP release in a cAMP-independent manner.	Flavonols	30-39	tumor necrosis factor	Homo sapiens	100-109
34065200-6	2021	This effect was attributed to flavonols, which might also account for the ability of RNLE to impair TNF-alpha/IL-4-induced TSLP release in a cAMP-independent manner.	Flavonols	30-39	interleukin 4	Homo sapiens	110-114
34065200-6	2021	This effect was attributed to flavonols, which might also account for the ability of RNLE to impair TNF-alpha/IL-4-induced TSLP release in a cAMP-independent manner.	Flavonols	30-39	thymic stromal lymphopoietin	Homo sapiens	123-127
34151085-4	2021	Meanwhile, pretreatment of the cells with these flavonols for 24 and 48 h before the indomethacin exposure could alleviate cytotoxicity and especially barrier loss, resulting in increased cell viability and transepithelial resistance, decreased LDH release, ROS production, and paracellular permeability, together with the promoted expression of three tight junction proteins zonula occluden-1, occludin, and claudin-1.	Flavonols	48-57	claudin 1	Rattus norvegicus	409-418
35636503-0	2022	Substrate-selective positive allosteric modulation of PTPRD"s phosphatase by flavonols.	Flavonols	77-86	protein tyrosine phosphatase receptor type D	Homo sapiens	54-59
35636503-5	2022	We also report discovery that quercetin and other flavonols, though not closely-related flavones, enhance rates of PTPRD"s dephosphorylation of a group of these candidate substrate PTPPs but not others.	Flavonols	50-59	protein tyrosine phosphatase receptor type D	Homo sapiens	115-120
35063619-2	2022	However, whether myricetin and other homologous dietary flavonols affect the activities of UDP-glucuronosyltransferases (UGT) enzymes and facilitated food-drug interactions remains unclear.	Flavonols	56-65	beta-1,3-glucuronyltransferase 2	Homo sapiens	91-119
35630816-3	2022	Flavanone 3-hydroxylase (F3H) catalyzes the conversion of naringenin into dihydroflavonols and is responsible for the biosynthesis of flavonols and anthocyanidins.	Flavonols	134-143	flavanone 3-hydroxylase	Nicotiana tabacum	0-23
35630816-3	2022	Flavanone 3-hydroxylase (F3H) catalyzes the conversion of naringenin into dihydroflavonols and is responsible for the biosynthesis of flavonols and anthocyanidins.	Flavonols	134-143	flavanone 3-hydroxylase	Nicotiana tabacum	25-28
35063619-2	2022	However, whether myricetin and other homologous dietary flavonols affect the activities of UDP-glucuronosyltransferases (UGT) enzymes and facilitated food-drug interactions remains unclear.	Flavonols	56-65	beta-1,3-glucuronyltransferase 2	Homo sapiens	121-124
35039839-7	2022	In Arabidopsis, over-expression of miR172 reduced flavonoid (including anthocyanins and flavonols) concentration and RNA transcript abundance of flavonoid genes in plantlets cultured on medium containing 7% sucrose.	Flavonols	88-97	MIR172a	Arabidopsis thaliana	35-41
35164310-5	2022	HPLC and MS/MS analyses of the enzymatic products showed that the VvANS-catalyzed oxidative transformation of (+)-dihydroflavonols, such as dihydroquercetin, dihydrokaempferol and dihydromyricetin, leads only to the corresponding flavonols.	Flavonols	230-239	leucoanthocyanidin dioxygenase	Vitis vinifera	66-71
3729991-8	1986	Evidence is presented that the mitochondrial respiratory bursts induced by both flavonols and their auto-oxidation resulted in the generation of O-2 and H2O2.	Flavonols	80-89	immunoglobulin kappa variable 1D-39	Homo sapiens	145-148
3497895-6	1987	These peroxyl radicals cannot be observed directly, but their reactions with the two flavonols, kaempferol and quercetin, acting as radical-scavenging antioxidants, produced strongly absorbing aroxyl radicals (ArO.).	Flavonols	85-94	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	210-213
33831169-0	2021	Involvement of the R2R3-MYB transcription factors MYB21 and its homologs in regulating the stamen flavonols accumulation in Arabidopsis.	Flavonols	98-107	myb domain protein 21	Arabidopsis thaliana	50-55
33831169-2	2021	Commonly found flavonols are synthesized from dihydroflavonols by flavonol synthase (FLS).	Flavonols	15-24	flavonol synthase 1	Arabidopsis thaliana	66-83
33831169-2	2021	Commonly found flavonols are synthesized from dihydroflavonols by flavonol synthase (FLS).	Flavonols	15-24	flavonol synthase 1	Arabidopsis thaliana	85-88
34009430-9	2021	CONCLUSIONS: Higher intakes of dietary flavonoids, specifically flavonols and flavan-3-ols, could be associated with better long-term treatment outcomes in nAMD patients receiving anti-VEGF therapy.	Flavonols	64-73	vascular endothelial growth factor A	Homo sapiens	185-189
34056184-5	2021	Molecular interactions between flavonols (kaempferol, quercetin, and myricetin) with human/murine CCL2 orthologs and their monomeric/dimeric variants were systematically investigated using a combination of biophysical approaches.	Flavonols	31-40	chemokine (C-C motif) ligand 2	Mus musculus	98-102
33948972-8	2021	Plant responses to the pre-treatment were notably different: (1) H2 O2 increased the activity of catalase (CAT, EC 1.11.1.6), phenylalanine ammonia lyase (PAL; EC 4.3.1.5) and peroxidase activities (POD, EC 1.11.1.7), and (2) the combined treatment induced epidermal flavonols which were key to drought tolerance.	Flavonols	267-276	catalase isozyme 1	Nicotiana tabacum	97-105
33923487-8	2021	Flavones, flavonols, flavanones, and isoflavones are the main subclasses of flavonoids reported as AhR modulators.	Flavonols	10-19	aryl hydrocarbon receptor	Homo sapiens	99-102
32916406-3	2021	In the present study, we identified 44 flavonols and chlorogenic acid in 30 samples of Highbush and Rabbiteye blueberry, using HPLC-DAD-ESI-MSn.	Flavonols	39-48	moesin	Homo sapiens	140-143
34056184-6	2021	Fluorescence studies have unveiled that flavonols interact with CCL2 orthologs specifically but with differential affinities.	Flavonols	40-49	chemokine (C-C motif) ligand 2	Mus musculus	64-68
34056184-8	2021	The NMR- and computational docking-based outcomes have strongly suggested that the flavonols interact with CCL2, comprising the N-terminal and beta1- and beta3-sheets.	Flavonols	83-92	chemokine (C-C motif) ligand 2	Mus musculus	107-111
34056184-8	2021	The NMR- and computational docking-based outcomes have strongly suggested that the flavonols interact with CCL2, comprising the N-terminal and beta1- and beta3-sheets.	Flavonols	83-92	BCL2 related protein A1	Homo sapiens	143-159
34056184-10	2021	Further, the binding surface of these flavonols to CCL2 orthologs was observed to be extensively overlapped with that of the receptor/GAG-binding surface, thus suggesting attenuation of CCL2-CCR2/GAG interactions in their presence.	Flavonols	38-47	chemokine (C-C motif) ligand 2	Mus musculus	51-55
34056184-10	2021	Further, the binding surface of these flavonols to CCL2 orthologs was observed to be extensively overlapped with that of the receptor/GAG-binding surface, thus suggesting attenuation of CCL2-CCR2/GAG interactions in their presence.	Flavonols	38-47	chemokine (C-C motif) ligand 2	Mus musculus	186-190
34056184-10	2021	Further, the binding surface of these flavonols to CCL2 orthologs was observed to be extensively overlapped with that of the receptor/GAG-binding surface, thus suggesting attenuation of CCL2-CCR2/GAG interactions in their presence.	Flavonols	38-47	C-C motif chemokine receptor 2	Homo sapiens	191-195
34056184-11	2021	Considering the pivotal role of CCL2 during monocyte/macrophage trafficking and the immunomodulatory features of these flavonols, their direct interactions highlight the promising role of flavonols as nutraceuticals.	Flavonols	188-197	chemokine (C-C motif) ligand 2	Mus musculus	32-36
33276066-3	2021	Cell pretreatment with 5 mumol/L flavonols also resisted cell barrier dysfunction by increasing transepithelial resistance, reducing paracellular permeability, and promoting mRNA and protein expression of three tight junction proteins zonula occluden-1, occludin, and claudin-1.	Flavonols	33-42	occludin	Rattus norvegicus	254-262
33568298-2	2021	WRKY11 promotes the biosynthesis of flavonoids in apple, but the molecular mechanism of WRKY11 regulating flavonols biosynthesis, and whether WRKY11 plays the same roles in other plants species remains to be further studied.	Flavonols	106-115	probable WRKY transcription factor 7	Malus domestica	88-94
33568298-2	2021	WRKY11 promotes the biosynthesis of flavonoids in apple, but the molecular mechanism of WRKY11 regulating flavonols biosynthesis, and whether WRKY11 plays the same roles in other plants species remains to be further studied.	Flavonols	106-115	probable WRKY transcription factor 7	Malus domestica	88-94
33986761-4	2021	Ectopic expression of AtCXE20 in Arabidopsis and maize resulted in phenotypes characteristic of strigolactone (SL)-deficient mutants, including increased branching and tillering, decreased plant height, delayed senescence, hyposensitivity to ethylene, and reduced flavonols.	Flavonols	264-273	carboxyesterase 20	Arabidopsis thaliana	22-29
33249077-0	2021	Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin-converting enzyme II receptor (ACE2).	Flavonols	0-9	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	82-87
33249077-0	2021	Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin-converting enzyme II receptor (ACE2).	Flavonols	0-9	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	135-139
33249077-0	2021	Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin-converting enzyme II receptor (ACE2).	Flavonols	0-9	angiotensin converting enzyme 2	Homo sapiens	188-192
33249077-5	2021	In this context, the present study reviews the efficacy of many dietary flavonols as potential antiviral drugs targeting the SARS-CoV-2 enzymes and proteins including Chymotrypsin-Like Protease (3CLpro), Papain Like protease (PLpro), Spike protein (S protein) and RNA-dependent RNA polymerase (RdRp), and also their ability to interact with the angiotensin-converting enzyme II (ACE2) receptor.	Flavonols	72-81	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	226-231
33249077-5	2021	In this context, the present study reviews the efficacy of many dietary flavonols as potential antiviral drugs targeting the SARS-CoV-2 enzymes and proteins including Chymotrypsin-Like Protease (3CLpro), Papain Like protease (PLpro), Spike protein (S protein) and RNA-dependent RNA polymerase (RdRp), and also their ability to interact with the angiotensin-converting enzyme II (ACE2) receptor.	Flavonols	72-81	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	234-239
33249077-5	2021	In this context, the present study reviews the efficacy of many dietary flavonols as potential antiviral drugs targeting the SARS-CoV-2 enzymes and proteins including Chymotrypsin-Like Protease (3CLpro), Papain Like protease (PLpro), Spike protein (S protein) and RNA-dependent RNA polymerase (RdRp), and also their ability to interact with the angiotensin-converting enzyme II (ACE2) receptor.	Flavonols	72-81	vitronectin	Homo sapiens	249-258
33249077-5	2021	In this context, the present study reviews the efficacy of many dietary flavonols as potential antiviral drugs targeting the SARS-CoV-2 enzymes and proteins including Chymotrypsin-Like Protease (3CLpro), Papain Like protease (PLpro), Spike protein (S protein) and RNA-dependent RNA polymerase (RdRp), and also their ability to interact with the angiotensin-converting enzyme II (ACE2) receptor.	Flavonols	72-81	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	294-298
33276066-3	2021	Cell pretreatment with 5 mumol/L flavonols also resisted cell barrier dysfunction by increasing transepithelial resistance, reducing paracellular permeability, and promoting mRNA and protein expression of three tight junction proteins zonula occluden-1, occludin, and claudin-1.	Flavonols	33-42	claudin 1	Rattus norvegicus	268-277
33276066-4	2021	Although indomethacin injury increased intracellular Ca2+ concentration ([Ca2+]i) and consequently caused JNK/Src activation, the flavonols could decrease [Ca2+]i and attenuate the calcium-mediated JNK/Src activation.	Flavonols	130-139	mitogen-activated protein kinase 8	Rattus norvegicus	198-201
33276066-4	2021	Although indomethacin injury increased intracellular Ca2+ concentration ([Ca2+]i) and consequently caused JNK/Src activation, the flavonols could decrease [Ca2+]i and attenuate the calcium-mediated JNK/Src activation.	Flavonols	130-139	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	202-205
33011286-5	2021	The results from real-time PCR and western-blot assays indicated that the cells treated with heated and unheated flavonols of 5 mumol/L dosage had up-regulated mRNA (1.13-1.81 folds) and protein (1.15-5.11 folds) expression for zonula occluden-1, occludin, and claudin-1 that are vital to the tight junctions (TJ) of the cells.	Flavonols	113-122	occludin	Rattus norvegicus	247-255
33011286-5	2021	The results from real-time PCR and western-blot assays indicated that the cells treated with heated and unheated flavonols of 5 mumol/L dosage had up-regulated mRNA (1.13-1.81 folds) and protein (1.15-5.11 folds) expression for zonula occluden-1, occludin, and claudin-1 that are vital to the tight junctions (TJ) of the cells.	Flavonols	113-122	claudin 1	Rattus norvegicus	261-270
32526471-2	2020	Toxicology research of HBCD on Arabidopsis thaliana (Col and fls1-3) not only shows the toxic effect of HBCD on plants, but also indicates that flavonols could improve plant resistance to HBCD, including root length, shoot biomass and chlorophyll content.	Flavonols	144-153	flavonol synthase 1	Arabidopsis thaliana	61-67
32696979-3	2020	In this study, two FLS genes were shown to be expressed synchronously with the flower development- and tissue- specific biosynthesis of flavonols in Freesia hybrida.	Flavonols	136-145	flavonol synthase 1	Arabidopsis thaliana	19-22
33839683-4	2021	We observed the tt4 and fls1 mutants, which produce no flavonols, have increased lateral root emergence.	Flavonols	55-64	flavonol synthase 1	Arabidopsis thaliana	24-28
31319297-0	2019	Flavonols and 4-thioflavonols as potential acetylcholinesterase and butyrylcholinesterase inhibitors: Synthesis, structure-activity relationship and molecular docking studies.	Flavonols	0-9	butyrylcholinesterase	Homo sapiens	68-89
32637131-4	2020	CsMYB60 activated CsFLS and CsLAR by binding to their promoters and directly or indirectly promoted the expression of CsbHLH42, CsMYC1, CsWD40, and CsTATA-box binding protein, resulting in the formation of complexes of these four proteins to increase the expression of Cs4CL and interact with CsTATA-box binding protein to regulate the expression of CsCHS, thereby regulating the biosynthesis of flavonols and PAs in cucumber.	Flavonols	396-405	TATA-box-binding protein	Cucumis sativus	148-174
32340142-6	2020	These properties could be attributed to the polyphenols, mainly anthocyanins and flavonols, detected by RP-HPLC-DAD-ESI-MSn.	Flavonols	81-90	moesin	Homo sapiens	120-123
31996451-7	2020	In Cox proportional hazards models, dietary intakes of flavonols were inversely associated with incident Alzheimer dementia in models adjusted for age, sex, education, APOE e4, and participation in cognitive and physical activities.	Flavonols	55-64	apolipoprotein E	Homo sapiens	168-172
32038672-7	2019	We further demonstrated that NtCHS-overexpressing plants and NtPT2-overexpressing plants also had increased flavonol and P accumulation and higher tolerance to low Pi stress, showing a similar phenotype to NtMYB12-overexpressing transgenic tobacco under low Pi stress.	Flavonols	108-116	inorganic phosphate transporter 1-4-like	Nicotiana tabacum	61-66
32038672-8	2019	These results suggested that tobacco NtMYB12 acts as a phosphorus starvation response enhancement factor and regulates NtCHS and NtPT2 expression, which results in increased flavonol and P accumulation and enhances tolerance to low Pi stress.	Flavonols	174-182	inorganic phosphate transporter 1-4-like	Nicotiana tabacum	129-134
31880932-1	2020	4G-alpha-Glucopyranosylrutin (monoglucosylrutin, MGR) is a flavonol glycoside with quercetin as an aglycone, is pale yellow in color, and engages in both copigmentation and anticopigmentation.	Flavonols	59-77	MGR6	Homo sapiens	49-52
32388479-2	2020	Quercetin and certain other planar flavones/flavonols can inhibit CK2 in high nanomolar concentrations; this may explain quercetin"s ability to slow the proliferation of RNA viruses in cell cultures and in mice.	Flavonols	44-53	casein kinase 2, alpha prime polypeptide	Mus musculus	66-69
30326823-7	2020	Flavonols and flavanones showed ROS scavenger activity (P < 0.05), attenuation of caspase-3 and -9 activation (P < 0.05) and restoration of the reduced chymotrypsin-like activity of proteasome 20S (P < 0.05) upon H2O2 exposure of APPswe cells.	Flavonols	0-9	caspase 3	Homo sapiens	85-101
32079157-7	2020	Together, these findings indicate a role of AtMyb12 in promoting the early stages of Cyst nematode infection, while flavonols produced through the action of AtFLS1 are essential for plant defense.	Flavonols	116-125	flavonol synthase 1	Arabidopsis thaliana	157-163
31944087-1	2020	BACKGROUND AND OBJECTIVE: Flavonols in plants are catalyzed by flavonol synthase (FLS) enzyme.	Flavonols	26-35	flavonol synthase 1	Arabidopsis thaliana	82-85
31609578-0	2019	Structure-Dependent Modulation of Substrate Binding and Biodegradation Activity of Pirin Proteins toward Plant Flavonols.	Flavonols	111-120	pirin	Homo sapiens	83-88
31894062-3	2019	Among tested flavonoids, the para substituted chloro containing flavonol (OF2) and flavone (F2) revealed a considerable in-vitro AChE and BuChE % inhibition with an IC50 values.	Flavonols	64-72	acetylcholinesterase	Mus musculus	129-133
30510558-4	2018	Following transient and stable expression in Nicotiana and Arabidopsis, respectively, the GSTs were recovered using Strep-Tactin affinity chromatography and the bound ligands desorbed and characterized by LC-MS. AtGSTF2 predominantly bound phenolic derivatives including S-glutathionylated lignanamides and methylated variants of the flavonols kaempferol and quercetin.	Flavonols	334-343	glutathione S-transferase PHI 2	Arabidopsis thaliana	212-219
30755473-4	2019	Here, metabolome and transcriptome analyses of anthers from mutant and overexpression genotypes revealed that Arabidopsis MYB99, a putative ortholog of the petunia (Petunia hybrida) floral scent regulator ODORANT1 (ODO1), controls the exclusive production of tapetum diglycosylated flavonols and hydroxycinnamic acid amides.	Flavonols	282-291	myb domain protein 99	Arabidopsis thaliana	122-127
31013947-6	2019	The flavonols were more active than the flavones against LDL oxidation, suggesting that hydroxyl group at C-3 and the catechol moiety at B-ring may play important roles in protecting LDL from oxidation.	Flavonols	4-13	complement C3	Homo sapiens	106-109
30567381-4	2018	The flavonols 3h, 3i, 3k, 3l and 3p exhibited moderate inhibitory effect against AChE, but significant inhibition against BChE.	Flavonols	4-13	acetylcholinesterase (Cartwright blood group)	Homo sapiens	81-85
30567381-4	2018	The flavonols 3h, 3i, 3k, 3l and 3p exhibited moderate inhibitory effect against AChE, but significant inhibition against BChE.	Flavonols	4-13	butyrylcholinesterase	Homo sapiens	122-126
29068268-0	2018	Structural insights into the binding mode of flavonols with the active site of matrix metalloproteinase-9 through molecular docking and molecular dynamic simulations studies.	Flavonols	45-54	matrix metallopeptidase 9	Homo sapiens	79-105
30380747-6	2018	OFIE, hydrolyzed (hdl) OFIE, and several flavonols induced the transcriptional activities of both CYP2B6 and CYP3A4 genes in HepG2 cells.	Flavonols	41-50	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	98-104
30380747-6	2018	OFIE, hydrolyzed (hdl) OFIE, and several flavonols induced the transcriptional activities of both CYP2B6 and CYP3A4 genes in HepG2 cells.	Flavonols	41-50	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	109-115
30380657-7	2018	Intakes of anthocyanins, catechins, and flavonols were strongly inversely associated with cardiovascular disease risk (anthocyanins: Hazard Ratio (HR)for a 1-point increment of 10 mg/day = 0.98 (0.96-0.99, p = 0.03, HRT3vs.T1 = 0.66 (0.52-0.83), ptrend = 0.0003; catechins: HRfor a 1-point increment of 10 mg/day = 0.98 (0.96-0.99), p = 0.02, HRT3vs.T1 = 0.74 (0.60-0.91), ptrend = 0.004; flavonols: HRfor a 1-point increment of 10 mg/day = 0.94 (0.90-0.99), p = 0.02, HRT3vs.T1 = 0.75 (0.61-0.94), ptrend = 0.006).	Flavonols	40-49	hes related family bHLH transcription factor with YRPW motif like	Homo sapiens	216-220
30380657-7	2018	Intakes of anthocyanins, catechins, and flavonols were strongly inversely associated with cardiovascular disease risk (anthocyanins: Hazard Ratio (HR)for a 1-point increment of 10 mg/day = 0.98 (0.96-0.99, p = 0.03, HRT3vs.T1 = 0.66 (0.52-0.83), ptrend = 0.0003; catechins: HRfor a 1-point increment of 10 mg/day = 0.98 (0.96-0.99), p = 0.02, HRT3vs.T1 = 0.74 (0.60-0.91), ptrend = 0.004; flavonols: HRfor a 1-point increment of 10 mg/day = 0.94 (0.90-0.99), p = 0.02, HRT3vs.T1 = 0.75 (0.61-0.94), ptrend = 0.006).	Flavonols	40-49	hes related family bHLH transcription factor with YRPW motif like	Homo sapiens	343-347
29953891-0	2018	Importance of the hydroxyl substituents in the B-ring of plant flavonols on their preferential binding interactions with VEGF G-quadruplex DNA: Multi-spectroscopic and molecular modeling studies.	Flavonols	63-72	vascular endothelial growth factor A	Homo sapiens	121-125
28978264-0	2018	Interaction of two flavonols with fat mass and obesity-associated protein investigated by fluorescence quenching and molecular docking.	Flavonols	19-28	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	34-73
28978264-1	2018	The binding of two flavonols with fat mass and obesity-associated protein (FTO) was studied using fluorescence spectroscopy, Stern-Volmer kinetics, UV-Vis absorption, and molecular docking.	Flavonols	19-28	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	34-73
28978264-1	2018	The binding of two flavonols with fat mass and obesity-associated protein (FTO) was studied using fluorescence spectroscopy, Stern-Volmer kinetics, UV-Vis absorption, and molecular docking.	Flavonols	19-28	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	75-78
30010959-9	2018	Metabolite and gene expression analysis also suggests a negative role for CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) in accumulation of flavonols in response to low temperature.	Flavonols	131-140	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	74-104
30010959-9	2018	Metabolite and gene expression analysis also suggests a negative role for CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) in accumulation of flavonols in response to low temperature.	Flavonols	131-140	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	106-110
30010959-10	2018	Overexpression of AtMYB12 enhanced accumulation of flavonols under low temperature in a light-dependent manner.	Flavonols	51-60	myb domain protein 12	Arabidopsis thaliana	18-25
29778797-0	2018	Discovery of potent alpha-glucosidase inhibitor flavonols: Insights into mechanism of action through inhibition kinetics and docking simulations.	Flavonols	48-57	sucrase-isomaltase	Homo sapiens	20-37
29068268-4	2018	The results show that flavonols can convincingly bind to active site of MMP-9 as demonstrated by their stable interactions at the S1" specificity pocket and favourable binding energies.	Flavonols	22-31	matrix metallopeptidase 9	Homo sapiens	72-77
28259640-4	2017	NADP(H)-dependent 17beta-HSD from the filamentous fungus Cochliobolus lunatus (17beta-HSDcl) has been the subject of extensive biochemical, kinetic and quantitative structure-activity relationship studies that have shown that the flavonols are the most potent inhibitors.	Flavonols	230-239	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	18-28
29505161-5	2018	In this study, we found that flavonols indirectly modify the rhm1 helical petal phenotype by altering rhamnose flux to the cell wall.	Flavonols	29-38	rhamnose biosynthesis 1	Arabidopsis thaliana	61-65
29505161-6	2018	Given this finding, we further investigated the relationship between flavonols and the cell wall in rhm1 cotyledons.	Flavonols	69-78	rhamnose biosynthesis 1	Arabidopsis thaliana	100-104
29403524-13	2018	These flavonols are endogenous inhibitors of auxin transport in planta; auxin levels in both roots and shoots of the cad1-3 mutant were in fact lower than those of the wild-type.	Flavonols	6-15	cinnamyl-alcohol dehydrogenase	Arabidopsis thaliana	117-121
28742839-0	2017	Flavonols reduce aortic atherosclerosis lesion area in apolipoprotein E deficient mice: A systematic review and meta-analysis.	Flavonols	0-9	apolipoprotein E	Mus musculus	55-71
28742839-9	2017	Sub-analyses suggested that the flavonols (SMD 1.31, 95% CI 0.66, 1.91) but not the flavan-3-ols (SMD 0.33, 95% CI -0.19, 0.85) significantly decreased atherosclerosis area.	Flavonols	32-41	small nuclear ribonucleoprotein D1	Mus musculus	43-48
28742839-12	2017	Based on the included studies, the flavonols appear to be the most effective flavonoids for reducing aortic atherosclerotic lesion area in apolipoprotein E deficient mice.	Flavonols	35-44	apolipoprotein E	Mus musculus	139-155
26498393-4	2015	Herein we report an in vitro inhibition study of human (h) CA isoforms hCAs I, II, IV, VII and XII with a panel of natural polyphenols including flavones, flavonols, flavanones, flavanols, isoflavones and depsides, some of which extracted from Quercus ilex and Salvia miltiorrhiza.	Flavonols	155-164	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	71-90
28165500-3	2017	Flavonols have been shown to alter auxin transport activity and changes in flavonol accumulation in the Arabidopsis thaliana rol1-2 mutant cause defects in auxin transport and seedling development.	Flavonols	0-9	rhamnose biosynthesis 1	Arabidopsis thaliana	125-131
27911811-2	2016	SULT1A1, the predominant isoform in adult liver, harbors two noninteracting allosteric sites, each of which binds a different molecular family: the catechins (naturally occurring flavonols) and nonsteroidal antiinflammatory drugs (NSAIDs).	Flavonols	179-188	sulfotransferase family 1A member 1	Homo sapiens	0-7
25724173-7	2016	Flavonols and resveratrol significantly reduced also the endothelial expression and release of M-CSF.	Flavonols	0-9	colony stimulating factor 1	Homo sapiens	95-100
26565375-8	2016	The related natural flavonols, kaempferol and quercetin were less potent inhibitors of TRPC5.	Flavonols	20-29	transient receptor potential cation channel subfamily C member 5	Homo sapiens	87-92
28232125-10	2017	We concluded that observed inhibition of CYP2E1 and CYP3A by some flavonols were not gender-dependent.	Flavonols	66-75	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	41-47
28232125-10	2017	We concluded that observed inhibition of CYP2E1 and CYP3A by some flavonols were not gender-dependent.	Flavonols	66-75	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	52-57
28165500-7	2017	In vivo analysis of PINOID action, a kinase known to influence PIN protein localization in a PP2A-antagonistic manner, revealed a negative impact of flavonols on PINOID activity.	Flavonols	149-158	serine/threonine protein phosphatase 2A	Arabidopsis thaliana	93-97
27041117-0	2016	Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor.	Flavonols	77-86	vitamin D receptor	Homo sapiens	104-122
27041117-4	2016	Therefore, we investigated systematically whether quercetin and other flavonols are agonists of rVDR, mouse VDR (mVDR), or human VDR (hVDR).	Flavonols	70-79	vitamin D receptor	Rattus norvegicus	96-100
26773068-9	2016	The prorelaxant effect retained in these structurally similar flavonols provides a novel pharmacological method for dual inhibition of PLCbeta and PDE4 and therefore may serve as a potential treatment option for acute ASM constriction.	Flavonols	62-71	phospholipase C, beta 1	Mus musculus	135-142
26773068-9	2016	The prorelaxant effect retained in these structurally similar flavonols provides a novel pharmacological method for dual inhibition of PLCbeta and PDE4 and therefore may serve as a potential treatment option for acute ASM constriction.	Flavonols	62-71	sphingomyelin phosphodiesterase 1	Homo sapiens	218-221
26793227-5	2015	Comparisons of expression patterns of gene related to the flavonoid biosynthesis indicated that disequilibrium expression of flavonol synthase (FLS) and dihydroflavonol-4-reductase (DFR) genes determined the accumulation of flavonols and anothcyanins in both red and white flowers of seven species.	Flavonols	224-233	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	125-142
26793227-5	2015	Comparisons of expression patterns of gene related to the flavonoid biosynthesis indicated that disequilibrium expression of flavonol synthase (FLS) and dihydroflavonol-4-reductase (DFR) genes determined the accumulation of flavonols and anothcyanins in both red and white flowers of seven species.	Flavonols	224-233	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	144-147
26793227-5	2015	Comparisons of expression patterns of gene related to the flavonoid biosynthesis indicated that disequilibrium expression of flavonol synthase (FLS) and dihydroflavonol-4-reductase (DFR) genes determined the accumulation of flavonols and anothcyanins in both red and white flowers of seven species.	Flavonols	224-233	dihydroflavonol-4-reductase	Nicotiana tabacum	153-180
26793227-5	2015	Comparisons of expression patterns of gene related to the flavonoid biosynthesis indicated that disequilibrium expression of flavonol synthase (FLS) and dihydroflavonol-4-reductase (DFR) genes determined the accumulation of flavonols and anothcyanins in both red and white flowers of seven species.	Flavonols	224-233	dihydroflavonol-4-reductase	Nicotiana tabacum	182-185
26793227-9	2015	On this basis, we propose a model in which FLS and DFR gene-products compete for common substrates in order to direct the biosynthesis of flavonols and anthocyanins, respectively, thereby determining white vs. red coloration of flowers.	Flavonols	138-147	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	43-46
26793227-9	2015	On this basis, we propose a model in which FLS and DFR gene-products compete for common substrates in order to direct the biosynthesis of flavonols and anthocyanins, respectively, thereby determining white vs. red coloration of flowers.	Flavonols	138-147	dihydroflavonol-4-reductase	Nicotiana tabacum	51-54
26497596-2	2015	A number of transcription factors have been used to upregulate-specific branches of phenylpropanoid metabolism, but by far the most effective has been the fruit-specific expression of AtMYB12 in tomato, which resulted in as much as 10% of fruit dry weight accumulating as flavonols and hydroxycinnamates.	Flavonols	272-281	myb domain protein 12	Arabidopsis thaliana	184-191
25981047-10	2015	This study demonstrated that AtMYB11 can be strategically used for enhancing the health beneficial flavonols in species other than Arabidopsis.	Flavonols	99-108	myb domain protein 11	Arabidopsis thaliana	29-36
26238175-9	2015	Overall, flavonols activate PXR in an analogue-specific and species-dependent manner.	Flavonols	9-18	nuclear receptor subfamily 1 group I member 2	Homo sapiens	28-31
26238175-11	2015	Understanding the structure-activity relationship of flavonols in hPXR activation may facilitate nutraceutical development efforts in the treatment of PXR-associated intestinal diseases, such as inflammatory bowel disease.	Flavonols	53-62	nuclear receptor subfamily 1 group I member 2	Homo sapiens	66-70
26238175-11	2015	Understanding the structure-activity relationship of flavonols in hPXR activation may facilitate nutraceutical development efforts in the treatment of PXR-associated intestinal diseases, such as inflammatory bowel disease.	Flavonols	53-62	nuclear receptor subfamily 1 group I member 2	Homo sapiens	67-70
26442064-3	2015	Dihydroflavonol 4-reductase (DFR) is a vital enzyme of the flavonoid pathway which displays major impact on the formation of anthocyanins, flavan 3-ols and flavonols.	Flavonols	156-165	putative anthocyanidin reductase	Gossypium hirsutum	0-27
26442064-3	2015	Dihydroflavonol 4-reductase (DFR) is a vital enzyme of the flavonoid pathway which displays major impact on the formation of anthocyanins, flavan 3-ols and flavonols.	Flavonols	156-165	putative anthocyanidin reductase	Gossypium hirsutum	29-32
26071529-9	2015	Among these, the transcripts coding for MYB and bZIP transcription factors, methyltranferases, and glucosyltranferases specific for flavonols, proteins, and factors belonging to the UV-B signalling pathway and co-localizing with the QTL regions are proposed as candidate genes for the fine regulation of flavonol content and composition in mature grapes.	Flavonols	132-141	MYB proto-oncogene, transcription factor	Homo sapiens	40-43
25712349-7	2015	A mixture of all flavonols significantly increased mRNA expression of the main glucose transporter Glut1 in HepG2 cells.	Flavonols	17-26	solute carrier family 2 member 1	Homo sapiens	99-104
26206248-9	2015	Taken together, results demonstrate that modulation of primary carbon metabolism and other pathways by AtMYB12 in tomato may lead to sufficient substrate supply for enhanced content of phenolics in general and flavonols in particular.	Flavonols	210-219	myb domain protein 12	Arabidopsis thaliana	103-110
25867625-12	2015	Moreover, the increased accumulation of the flavonols quercetin and kaempferol appears closely related to the increase of PAL5, chalcone synthase (CHS) and flavonol synthase/flavanone 3-hydroxylase-like (FLS) genes.	Flavonols	44-53	phenylalanine ammonia-lyase	Solanum lycopersicum	122-126
25867625-12	2015	Moreover, the increased accumulation of the flavonols quercetin and kaempferol appears closely related to the increase of PAL5, chalcone synthase (CHS) and flavonol synthase/flavanone 3-hydroxylase-like (FLS) genes.	Flavonols	44-53	chalcone synthase 1	Solanum lycopersicum	128-145
25867625-12	2015	Moreover, the increased accumulation of the flavonols quercetin and kaempferol appears closely related to the increase of PAL5, chalcone synthase (CHS) and flavonol synthase/flavanone 3-hydroxylase-like (FLS) genes.	Flavonols	44-53	LOC101250319	Solanum lycopersicum	156-202
25867625-12	2015	Moreover, the increased accumulation of the flavonols quercetin and kaempferol appears closely related to the increase of PAL5, chalcone synthase (CHS) and flavonol synthase/flavanone 3-hydroxylase-like (FLS) genes.	Flavonols	44-53	LOC101250319	Solanum lycopersicum	204-207
25442631-4	2015	More interestingly, it was the flavonols, not the flavanols, which showed the inhibitory activities against alpha-glucosidase and pancreatic lipase.	Flavonols	31-40	sucrase-isomaltase	Homo sapiens	108-125
25541401-1	2015	Photophysical properties of a bioactive flavonol which can be used as a model for polyhydroxylated natural flavonols, 3,6-diHydroxyflavone (3,6-diHF) in cyclodextrins (CDs)/bovine serum albumin (BSA) systems have been studied by absorption and fluorescence spectroscopy.	Flavonols	107-116	albumin	Homo sapiens	180-193
25622620-0	2015	Evaluation of flavonols and derivatives as human cathepsin B inhibitor.	Flavonols	14-23	cathepsin B	Homo sapiens	49-60
25444741-8	2015	Insulin and insulin resistance were inversely correlated with intakes of flavones and flavonols among the male subjects.	Flavonols	86-95	insulin	Homo sapiens	0-7
25444741-8	2015	Insulin and insulin resistance were inversely correlated with intakes of flavones and flavonols among the male subjects.	Flavonols	86-95	insulin	Homo sapiens	12-19
25580686-0	2015	The role of selected flavonols in tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) expression on activated RAW 264.7 macrophages.	Flavonols	21-30	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	102-107
25580686-3	2015	In this study, the expression level of TRAIL-R1 on murine RAW264.7 macrophages in the presence of selected flavonols: galangin, kaempferol, kaempferide and quercetin, which differ from their phenyl ring substituents, were studied.	Flavonols	107-116	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	39-44
25622620-6	2015	The results demonstrated polyhydroxylated flavonols as promising inhibitors of catB.	Flavonols	42-51	cathepsin B	Homo sapiens	79-83
25315603-4	2014	The elevated flavonols are required for the growth effect, because the transparent testa4 mutation reverses the noa1 mutant root elongation phenotype.	Flavonols	13-22	P-loop containing nucleoside triphosphate hydrolases superfamily protein	Arabidopsis thaliana	112-116
25518925-2	2015	In this study, we analyzed the effect of flavonols on MMP-9 expression in phorbol-12-myristate-13-acetate (PMA)-induced human fibrosarcoma HT-1080 cells.	Flavonols	41-50	matrix metallopeptidase 9	Homo sapiens	54-59
25518925-8	2015	Therefore, these flavonols could be used as chemopreventive agents to lower the risk of diseases involving MMP-9.	Flavonols	17-26	matrix metallopeptidase 9	Homo sapiens	107-112
25468534-10	2015	A comparison of a wide spectrum of beta-glucosides showed that recombinant BGLU15 preferentially hydrolyses the 3-O-beta-glucosides of flavonols, but does not attack quercetin 3-O-alpha-rhamnoside, quercetin 3-O-beta-galactoside and rutin.	Flavonols	135-144	beta glucosidase 15	Arabidopsis thaliana	75-81
25143139-9	2014	The AChE inhibitions generally increase with the increasing affinities of flavonoids within the class, especially for flavones and flavonols.	Flavonols	131-140	acetylcholinesterase (Cartwright blood group)	Homo sapiens	4-8
25006027-3	2014	Complementation of are with the p35S:F3H transgene reduced naringenin and increased flavonols to wild-type levels.	Flavonols	84-93	flavanone 3-dioxygenase	Solanum lycopersicum	32-40
24954290-2	2014	Flavonols exert a favourable effect on endothelium-derived vasodilation via the stimulation of nitric oxide-synthase (NOS), the increased availability of l-arginine (NO donor) and the decreased degradation of NO.	Flavonols	0-9	nitric oxide synthase 2	Homo sapiens	95-116
24492725-4	2014	Coumarins, flavonols, and catechin inhibited hMATE1 activity.	Flavonols	11-20	solute carrier family 47 member 1	Homo sapiens	45-51
25026921-0	2014	Apple flavonols and n-3 polyunsaturated fatty acid-rich fish oil lowers blood C-reactive protein in rats with hypercholesterolemia and acute inflammation.	Flavonols	6-15	C-reactive protein	Rattus norvegicus	78-96
24846090-5	2014	The results suggest that AtMYB111 expression in transgenic tobacco enhances expression of genes of the phenylpropanoid pathway leading to an elevated content of flavonols.	Flavonols	161-170	myb domain protein 111	Arabidopsis thaliana	25-33
24720993-6	2014	It was found that flavonols (quercetin and myricetin) and flavans (epicatechin gallate (ECG) and epigallocatechin (EGC)) showed higher TOD inhibitory activity than flavones and flavanones.	Flavonols	18-27	monoamine oxidase B	Homo sapiens	135-138
24353343-3	2014	Compared with the RG diet, the MYB10 diet contained elevated concentrations of the flavonoid subclasses anthocyanins, flavanol monomers (epicatechin) and oligomers (procyanidin B2), and flavonols (quercetin glycosides), but other plant secondary metabolites were largely unaltered.	Flavonols	186-195	transcription factor MYB113-like	Malus domestica	31-36
24102754-0	2014	Co-expression of Arabidopsis transcription factor, AtMYB12, and soybean isoflavone synthase, GmIFS1, genes in tobacco leads to enhanced biosynthesis of isoflavones and flavonols resulting in osteoprotective activity.	Flavonols	168-177	myb domain protein 12	Arabidopsis thaliana	51-58
23050660-2	2012	To define the functional features of two such families of compounds, the flavonols and the ethyl caffeates, we have determined the high-resolution structures of representative inhibitors in complex with human pancreatic alpha-amylase.	Flavonols	73-82	amylase alpha 2A	Homo sapiens	209-233
24118612-4	2013	Seedlings and seeds of mTCP3 plants were found to hyper-accumulate flavonols, anthocyanins and proanthocyanidins, whereas levels of proanthocyanidins were slightly reduced in TCP3SRDX plants.	Flavonols	67-76	t-complex protein 3	Mus musculus	23-28
24118612-4	2013	Seedlings and seeds of mTCP3 plants were found to hyper-accumulate flavonols, anthocyanins and proanthocyanidins, whereas levels of proanthocyanidins were slightly reduced in TCP3SRDX plants.	Flavonols	67-76	chaperonin-containing T-complex subunit CCT3	Saccharomyces cerevisiae S288C	24-28
23801300-4	2013	Two UGTs isolated from Arabidopsis thaliana, AtUGT78D2 and AtUGT78D3, showed 89 % amino acid sequence similarity (75 % amino acid sequence identity) and both attached a sugar to the 3-hydroxyl group of flavonols using a UDP-sugar.	Flavonols	202-211	UDP-glucosyl transferase 78D2	Arabidopsis thaliana	45-54
23801300-4	2013	Two UGTs isolated from Arabidopsis thaliana, AtUGT78D2 and AtUGT78D3, showed 89 % amino acid sequence similarity (75 % amino acid sequence identity) and both attached a sugar to the 3-hydroxyl group of flavonols using a UDP-sugar.	Flavonols	202-211	UDP-glucosyl transferase 78D3	Arabidopsis thaliana	59-68
23760261-2	2013	In this context, we have examined five classes of plant-derived flavonoids (flavonols, flavones, flavanones, catechins, and cyanidin) for their ability to regulate cytokine release induced by the Toll-like receptor 2 (TLR2) agonist Pam3CSK4.	Flavonols	76-85	toll like receptor 2	Homo sapiens	196-216
23760261-3	2013	We found that the flavonols selectively co-stimulated IL-1beta secretion but had no impact on the secretion of IL-6.	Flavonols	18-27	interleukin 1 beta	Homo sapiens	54-62
23760261-6	2013	In contrast, the methylated flavonols enhanced IL-1beta gene expression through transcriptional regulation, involving mechanisms that operate downstream of the initial NF-kappaB and STAT1 activation events.	Flavonols	28-37	interleukin 1 beta	Homo sapiens	47-55
23760261-6	2013	In contrast, the methylated flavonols enhanced IL-1beta gene expression through transcriptional regulation, involving mechanisms that operate downstream of the initial NF-kappaB and STAT1 activation events.	Flavonols	28-37	signal transducer and activator of transcription 1	Homo sapiens	182-187
23279849-8	2013	Comparing the activities of morin with those of four structurally related flavonols demonstrated the importance of hydroxyl groups in the B ring in inhibiting STAT3 activation.	Flavonols	74-83	signal transducer and activator of transcription 3	Homo sapiens	159-164
22980861-4	2012	It was found that all the three dietary flavonols could ameliorate the oxidative stress, enhance the activity of Na(+),K(+)-ATPase and regulate the expression of ERK-CREB pathway in mice.	Flavonols	40-49	mitogen-activated protein kinase 1	Mus musculus	162-165
22980861-4	2012	It was found that all the three dietary flavonols could ameliorate the oxidative stress, enhance the activity of Na(+),K(+)-ATPase and regulate the expression of ERK-CREB pathway in mice.	Flavonols	40-49	cAMP responsive element binding protein 1	Mus musculus	166-170
23809009-8	2013	The flavonols 3-Hydroxyflavone, galangin, quercetin and tamarixetin transactivated the ligand-binding domain of hCAR-WT, but only 3-hydroxyflavone recruited SRC-1, SRC-2 and SRC-3 to the receptor.	Flavonols	4-13	CXADR Ig-like cell adhesion molecule	Homo sapiens	112-116
23809009-8	2013	The flavonols 3-Hydroxyflavone, galangin, quercetin and tamarixetin transactivated the ligand-binding domain of hCAR-WT, but only 3-hydroxyflavone recruited SRC-1, SRC-2 and SRC-3 to the receptor.	Flavonols	4-13	nuclear receptor coactivator 2	Homo sapiens	164-169
23809009-8	2013	The flavonols 3-Hydroxyflavone, galangin, quercetin and tamarixetin transactivated the ligand-binding domain of hCAR-WT, but only 3-hydroxyflavone recruited SRC-1, SRC-2 and SRC-3 to the receptor.	Flavonols	4-13	nuclear receptor coactivator 3	Homo sapiens	174-179
23180627-6	2013	Once produced in the gut by digestion, glucose is absorbed by SGLT1 and GLUT2 transporters, inhibited by flavonols and flavonol glycosides, phlorizin and green tea catechins.	Flavonols	105-114	solute carrier family 5 member 1	Homo sapiens	62-67
23180627-6	2013	Once produced in the gut by digestion, glucose is absorbed by SGLT1 and GLUT2 transporters, inhibited by flavonols and flavonol glycosides, phlorizin and green tea catechins.	Flavonols	105-114	solute carrier family 2 member 2	Homo sapiens	72-77
21557334-1	2012	In vitro studies have found that flavanol epigallocatechin (EGC) and flavonols, but not flavanol epicatechin (EC), activate glutathione S-transferases (GSTs), a family of phase II enzymes that detoxify reactive oxygen species, such as catechol estrogen metabolites.	Flavonols	69-78	glutathione S-transferase mu 1	Homo sapiens	152-156
22258746-2	2012	Whereas CCoAOMT1 displays a strong preference for caffeoyl coenzyme A, COMT1 preferentially methylates 5-hydroxyferuloyl CoA derivatives and also performs methylation of flavonols with vicinal aromatic dihydroxy groups, such as quercetin.	Flavonols	170-179	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	8-16
22258746-2	2012	Whereas CCoAOMT1 displays a strong preference for caffeoyl coenzyme A, COMT1 preferentially methylates 5-hydroxyferuloyl CoA derivatives and also performs methylation of flavonols with vicinal aromatic dihydroxy groups, such as quercetin.	Flavonols	170-179	O-methyltransferase 1	Arabidopsis thaliana	71-76
29243607-3	2012	The active components were identified as prenylated flavonols (2-4) that inhibited two related human cholinesterases in a dose-dependent manner, with IC50"s ranging between 0.8 and 3.1muM and between 0.5 and 24.7muM against human acetylcholinesterase (hAChE) and butylcholinesterase (BChE), respectively.	Flavonols	52-61	acetylcholinesterase (Cartwright blood group)	Homo sapiens	252-257
29243607-3	2012	The active components were identified as prenylated flavonols (2-4) that inhibited two related human cholinesterases in a dose-dependent manner, with IC50"s ranging between 0.8 and 3.1muM and between 0.5 and 24.7muM against human acetylcholinesterase (hAChE) and butylcholinesterase (BChE), respectively.	Flavonols	52-61	butyrylcholinesterase	Homo sapiens	263-282
29243607-3	2012	The active components were identified as prenylated flavonols (2-4) that inhibited two related human cholinesterases in a dose-dependent manner, with IC50"s ranging between 0.8 and 3.1muM and between 0.5 and 24.7muM against human acetylcholinesterase (hAChE) and butylcholinesterase (BChE), respectively.	Flavonols	52-61	butyrylcholinesterase	Homo sapiens	284-288
29243607-5	2012	Flavonols (2-4) showed mixed inhibition kinetics as well as slow and time-dependent reversible inhibition toward hAChE.	Flavonols	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-118
21557334-6	2012	Urinary excretion of flavonols and flavanols, particularly EGC (P = 0.02), was significantly higher among women null for GSTM1 than those positive for GSTM1.	Flavonols	21-30	glutathione S-transferase mu 1	Homo sapiens	121-126
21557334-6	2012	Urinary excretion of flavonols and flavanols, particularly EGC (P = 0.02), was significantly higher among women null for GSTM1 than those positive for GSTM1.	Flavonols	21-30	glutathione S-transferase mu 1	Homo sapiens	151-156
21557334-7	2012	Flavonols and flavanols (EGC in particular) were associated with a reduced risk of breast cancer among those null for GSTM1 and GSTT1, with a P-value of 0.04 for the interaction between EGC and GSTM1 polymorphism.	Flavonols	0-9	glutathione S-transferase mu 1	Homo sapiens	118-123
21557334-7	2012	Flavonols and flavanols (EGC in particular) were associated with a reduced risk of breast cancer among those null for GSTM1 and GSTT1, with a P-value of 0.04 for the interaction between EGC and GSTM1 polymorphism.	Flavonols	0-9	glutathione S-transferase theta 1	Homo sapiens	128-133
21557334-7	2012	Flavonols and flavanols (EGC in particular) were associated with a reduced risk of breast cancer among those null for GSTM1 and GSTT1, with a P-value of 0.04 for the interaction between EGC and GSTM1 polymorphism.	Flavonols	0-9	glutathione S-transferase mu 1	Homo sapiens	194-199
21557334-8	2012	In contrast, among women possessing both GSTM1 and GSTT1, breast cancer risk increased with levels of flavonols, particularly kaempferol.	Flavonols	102-111	glutathione S-transferase mu 1	Homo sapiens	41-46
21557334-8	2012	In contrast, among women possessing both GSTM1 and GSTT1, breast cancer risk increased with levels of flavonols, particularly kaempferol.	Flavonols	102-111	glutathione S-transferase theta 1	Homo sapiens	51-56
22352375-8	2012	In conclusion, molecular docking studies explain why SULT1A3 exclusively mediates sulfonation at the 7-OH position of flavones/flavonols, and correlation studies indicate that SULT1A3 is the main isoform responsible for flavonoid sulfonation in the Caco-2 cells.	Flavonols	127-136	sulfotransferase family 1A member 3	Homo sapiens	53-60
22352375-8	2012	In conclusion, molecular docking studies explain why SULT1A3 exclusively mediates sulfonation at the 7-OH position of flavones/flavonols, and correlation studies indicate that SULT1A3 is the main isoform responsible for flavonoid sulfonation in the Caco-2 cells.	Flavonols	127-136	sulfotransferase family 1A member 3	Homo sapiens	176-183
21472492-0	2011	Regioselective glucuronidation of flavonols by six human UGT1A isoforms.	Flavonols	34-43	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	57-62
22307611-5	2012	Using reduction-of-function and overexpression approaches in parallel, we demonstrate that the WRKY23 transcription factor is needed for proper root growth and development by stimulating the local biosynthesis of flavonols.	Flavonols	213-222	WRKY DNA-binding protein 23	Arabidopsis thaliana	95-101
22249996-9	2012	The dependence of the PAL feedback inhibition on flavonols was confirmed by chemical complementation of tt4 ugt78d1 ugt78d2 using naringenin, a downstream flavonoid intermediate, which restored the PAL repression.	Flavonols	49-58	UDP-glucosyl transferase 78D1	Arabidopsis thaliana	108-115
22249996-9	2012	The dependence of the PAL feedback inhibition on flavonols was confirmed by chemical complementation of tt4 ugt78d1 ugt78d2 using naringenin, a downstream flavonoid intermediate, which restored the PAL repression.	Flavonols	49-58	UDP-glucosyl transferase 78D2	Arabidopsis thaliana	116-123
22300659-6	2012	Counter screening, where the ability of these chosen flavonols to inhibit caspase 8 binding to itself was assessed, demonstrated that myricetin, morin and quercetin inhibited GST-E6 and His-caspase 8 binding in a specific manner.	Flavonols	53-62	caspase 8	Homo sapiens	74-83
22300659-6	2012	Counter screening, where the ability of these chosen flavonols to inhibit caspase 8 binding to itself was assessed, demonstrated that myricetin, morin and quercetin inhibited GST-E6 and His-caspase 8 binding in a specific manner.	Flavonols	53-62	caspase 8	Homo sapiens	190-199
22153059-5	2011	During the roasting process, tree nut isoflavones, flavanols and flavonols were found to be more resistant to heat than the anthocyanins, PAC and trans-resveratrol.	Flavonols	65-74	NUT midline carcinoma family member 1	Homo sapiens	34-37
21472492-2	2011	We aimed to determine the regioselective glucuronidation of four model flavonols using six expressed human UGT1A isoforms (UGT1A1, 1A3, 1A7, 1A8, 1A9, 1A10).	Flavonols	71-80	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	107-112
21472492-2	2011	We aimed to determine the regioselective glucuronidation of four model flavonols using six expressed human UGT1A isoforms (UGT1A1, 1A3, 1A7, 1A8, 1A9, 1A10).	Flavonols	71-80	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	123-129
21472492-3	2011	METHODS: In vitro reaction kinetic profiles of six UGT1A-mediated metabolism of four flavonols (all with 7-OH group) were characterized; kinetic parameters (K(m), V(max) and CL(int) = V(max)/K(m)) were determined.	Flavonols	85-94	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	51-56
21472492-8	2011	CONCLUSION: UGT1A isoforms displayed distinct positional preferences between 3-OH and 7-OH of flavonols.	Flavonols	94-103	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	12-17
20460144-10	2010	All three tested flavonols significantly (P<0.01) inhibited histamine content at 10 mg/kg, and phospholipase A(2) (PLA(2)) and EPO activities at 30 mg/kg (p.o.)	Flavonols	17-26	erythropoietin	Cavia porcellus	130-133
21502189-3	2011	The rol1-2 (for repressor of lrx1) mutation of Arabidopsis (Arabidopsis thaliana) induces aberrant accumulation of flavonols and a cell-growth phenotype in the shoot.	Flavonols	115-124	rhamnose biosynthesis 1	Arabidopsis thaliana	4-10
21502189-3	2011	The rol1-2 (for repressor of lrx1) mutation of Arabidopsis (Arabidopsis thaliana) induces aberrant accumulation of flavonols and a cell-growth phenotype in the shoot.	Flavonols	115-124	leucine-rich repeat/extensin 1	Arabidopsis thaliana	29-33
21502189-5	2011	Indeed, the identification of several transparent testa, myb, and fls1 (for flavonol synthase1) alleles in a rol1-2 suppressor screen provides genetic evidence that flavonols interfere with shoot development in rol1-2 seedlings.	Flavonols	165-174	flavonol synthase 1	Arabidopsis thaliana	66-70
21502189-5	2011	Indeed, the identification of several transparent testa, myb, and fls1 (for flavonol synthase1) alleles in a rol1-2 suppressor screen provides genetic evidence that flavonols interfere with shoot development in rol1-2 seedlings.	Flavonols	165-174	rhamnose biosynthesis 1	Arabidopsis thaliana	109-115
21502189-5	2011	Indeed, the identification of several transparent testa, myb, and fls1 (for flavonol synthase1) alleles in a rol1-2 suppressor screen provides genetic evidence that flavonols interfere with shoot development in rol1-2 seedlings.	Flavonols	165-174	rhamnose biosynthesis 1	Arabidopsis thaliana	211-217
21502189-8	2011	Inhibition of flavonol biosynthesis in rol1-2 fls1-3 restores naphthalene-1-acetic acid transport to wild-type levels, indicating a very specific mode of action of flavonols on the auxin transport machinery.	Flavonols	164-173	rhamnose biosynthesis 1	Arabidopsis thaliana	39-45
21502189-8	2011	Inhibition of flavonol biosynthesis in rol1-2 fls1-3 restores naphthalene-1-acetic acid transport to wild-type levels, indicating a very specific mode of action of flavonols on the auxin transport machinery.	Flavonols	164-173	flavonol synthase 1	Arabidopsis thaliana	46-50
21329749-8	2011	The inhibitory potency of flavonols on CYP1A1 activity in presence of B[a]P was much stronger for the aglycones than for the 3-O-rutinosides, explaining the slight effect observed with the GBE, mainly composed of glycosylated flavonoids.	Flavonols	26-35	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	39-45
21278283-8	2011	These results indicate that two of the major flavonols found in green tea have a substantial effect on the function of OATPs expressed in enterocytes and hepatocytes and can potentially alter the pharmacokinetics of drugs and other OATP substrates.	Flavonols	45-54	solute carrier organic anion transporter family member 1A2	Homo sapiens	119-123
21077260-1	2011	It was previously reported that prenylated flavonols from Sophora flavescens are inhibitors of rat lens aldose reductase (RLAR), human recombinant aldose reductase (HRAR), advanced glycation endproducts (AGE), beta-secretase (BACE1) and cholinesterases (ChE).	Flavonols	43-52	aldo-keto reductase family 1 member B1	Rattus norvegicus	104-120
21077260-1	2011	It was previously reported that prenylated flavonols from Sophora flavescens are inhibitors of rat lens aldose reductase (RLAR), human recombinant aldose reductase (HRAR), advanced glycation endproducts (AGE), beta-secretase (BACE1) and cholinesterases (ChE).	Flavonols	43-52	aldo-keto reductase family 1 member B	Homo sapiens	147-163
21077260-1	2011	It was previously reported that prenylated flavonols from Sophora flavescens are inhibitors of rat lens aldose reductase (RLAR), human recombinant aldose reductase (HRAR), advanced glycation endproducts (AGE), beta-secretase (BACE1) and cholinesterases (ChE).	Flavonols	43-52	beta-secretase 1	Homo sapiens	226-231
22145036-6	2011	Flavonol synthase (FLS) is an important enzyme of flavonoid pathway that catalyzes the formation of flavonols.	Flavonols	100-109	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	0-17
22145036-6	2011	Flavonol synthase (FLS) is an important enzyme of flavonoid pathway that catalyzes the formation of flavonols.	Flavonols	100-109	flavonol synthase/flavanone 3-hydroxylase-like	Nicotiana tabacum	19-22
20444210-10	2010	These results confirm that KAN4 is a regulatory protein which modulates the content of flavonols and PA in Arabidopsis seeds.	Flavonols	87-96	Homeodomain-like superfamily protein	Arabidopsis thaliana	27-31
21487097-2	2011	Anthocyanins and flavonols are derived from Phe and share common precursors, dihydroflavonols, which are substrates for both flavonol synthase and dihydroflavonol 4-reductase.	Flavonols	17-26	dihydroflavonol 4-reductase	Arabidopsis thaliana	147-174
21068207-0	2011	Three-dimensional quantitative structure-activity relationship studies on UGT1A9-mediated 3-O-glucuronidation of natural flavonols using a pharmacophore-based comparative molecular field analysis model.	Flavonols	121-130	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	74-80
21068207-3	2011	This article aims to construct position (3-OH)-specific comparative molecular field analysis (CoMFA) models to describe UDP-glucuronosyltransferase (UGT) 1A9-mediated glucuronidation of flavonols, which can be used to design poor UGT1A9 substrates.	Flavonols	186-195	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	120-157
21068207-4	2011	The kinetics of recombinant UGT1A9-mediated 3-O-glucuronidation of 30 flavonols was characterized, and kinetic parameters (K(m), V(max), CL(int)) were obtained.	Flavonols	70-79	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	28-34
21068207-6	2011	To model UGT1A9-mediated glucuronidation, 30 flavonols were split into the training (23 compounds) and test (7 compounds) sets.	Flavonols	45-54	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	9-15
21068207-10	2011	In conclusion, the approach of coupling CoMFA analysis with a pharmacophore-based structural alignment is viable for constructing a predictive model for regiospecific glucuronidation rates of flavonols by UGT1A9.	Flavonols	192-201	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	205-211
20383790-5	2010	RESULTS: Flavonols inhibited the secretion of allergic mediators in RBL-2H3 cells and suppressed the CD23 mRNA expression and p38 MAPK activation in IL-4 stimulated Caco-2 cells.	Flavonols	9-18	Fc epsilon receptor II	Rattus norvegicus	101-105
20383790-5	2010	RESULTS: Flavonols inhibited the secretion of allergic mediators in RBL-2H3 cells and suppressed the CD23 mRNA expression and p38 MAPK activation in IL-4 stimulated Caco-2 cells.	Flavonols	9-18	interleukin 4	Rattus norvegicus	149-153
20383790-6	2010	Flavonols also suppressed IgE-OVA induced extra signal-regulated protein kinase (ERK) activation and chemokine release.	Flavonols	0-9	immunoglobulin heavy constant epsilon	Homo sapiens	26-29
20383790-6	2010	Flavonols also suppressed IgE-OVA induced extra signal-regulated protein kinase (ERK) activation and chemokine release.	Flavonols	0-9	mitogen-activated protein kinase 1	Homo sapiens	81-84
20450880-4	2010	Flavones and flavonols suppressed the TCDD-induced nuclear translocation of the AhR and dissociation of its partner proteins, heat shock protein 90 and X-associated protein 2, whereas flavanones and catechins did not.	Flavonols	13-22	aryl-hydrocarbon receptor	Mus musculus	80-83
20580386-1	2010	Cabernet Sauvignon 3",5"-O-methyltransferase showing strong preference for anthocyanins and glycosylated flavonols.	Flavonols	105-114	O-methyltransferase	Vitis vinifera	25-44
20621794-8	2010	Transfer of UGT78K1 into the Arabidopsis T-DNA mutant (ugt78d2) deficient in anthocyanidin and flavonol 3-O-glucosyltransferase activity, restored the accumulation of anthocyanins and flavonols, suggesting the in vivo function of the enzyme as a flavonoid 3-O-glucosyltransferase.	Flavonols	184-193	UDP-glucose:flavonoid 3-O-glucosyltransferase	Glycine max	12-19
20696580-4	2010	Flavones and flavonols indicated relatively strong inhibitory effects on CYP1s compared with flavanone that does not have the double bond between C-positions 2 and 3 on the C-ring.	Flavonols	13-22	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	73-77
20696580-6	2010	In particular, methoxy types of flavones and flavonols such as chrysoeriol and isorhamnetin showed strong and selective inhibition against CYP1B1.	Flavonols	45-54	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	139-145
20059741-3	2010	By homology with an Arabidopsis flavonol synthase (AtFLS1), we cloned a maize gene encoding a protein (ZmFLS1) capable of converting the dihydrokaempferol (DHK) and dihydroquercetin (DHQ) dihydroflavonols to the corresponding flavonols, kaempferol (K) and quercetin (Q).	Flavonols	195-204	flavonol synthase 1	Arabidopsis thaliana	51-57
20153296-2	2010	In this work we analyzed the effect of a group of 20 structurally related flavonoids, including flavones, flavonols and isoflavones, on the production of vascular endothelial growth factor (VEGF) induced by hypoxia in NCI-H157 cells.	Flavonols	106-115	vascular endothelial growth factor A	Homo sapiens	154-188
20153296-2	2010	In this work we analyzed the effect of a group of 20 structurally related flavonoids, including flavones, flavonols and isoflavones, on the production of vascular endothelial growth factor (VEGF) induced by hypoxia in NCI-H157 cells.	Flavonols	106-115	vascular endothelial growth factor A	Homo sapiens	190-194
20484173-0	2010	Interleukin-6 as a potential indicator for prevention of high-risk adenoma recurrence by dietary flavonols in the polyp prevention trial.	Flavonols	97-106	interleukin 6	Homo sapiens	0-13
20484173-3	2010	We estimated odds ratios and 95% confidence intervals (95% CI) to determine whether serum IL-6 was associated with colorectal adenoma recurrence and flavonol intake and thus may serve as a risk indicator and as a response indicator to dietary flavonols.	Flavonols	243-252	interleukin 6	Homo sapiens	90-94
20484173-5	2010	Intake of flavonols, especially of isorhamnetin, kaempferol, and quercetin, was inversely associated with serum IL-6 concentrations (highest versus lowest flavonol intake quartile, 1.80 versus 2.20 pg/mL) and high-risk (OR, 0.51; 95% CI, 0.26-0.98) and advanced adenoma recurrence (OR, 0.17; 95% CI, 0.06-0.50).	Flavonols	10-19	interleukin 6	Homo sapiens	112-116
20484173-8	2010	Our results suggest that serum IL-6 may serve as a risk indicator and as a response indicator to dietary flavonols for colorectal cancer prevention.	Flavonols	105-114	interleukin 6	Homo sapiens	31-35
20415488-0	2010	Evaluation of inhibitory actions of flavonols and related substances on lysophospholipase d activity of serum autotaxin by a convenient assay using a chromogenic substrate.	Flavonols	36-45	phospholipase B1	Homo sapiens	72-89
20415488-0	2010	Evaluation of inhibitory actions of flavonols and related substances on lysophospholipase d activity of serum autotaxin by a convenient assay using a chromogenic substrate.	Flavonols	36-45	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	110-119
20415488-4	2010	Flavonols, phenolic acids, free fatty acids, and N-acyltyrosines inhibited lysoPLD activity in a micromolar range.	Flavonols	0-9	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	75-82
19917299-0	2010	Anti-depressant natural flavonols modulate BDNF and beta amyloid in neurons and hippocampus of double TgAD mice.	Flavonols	24-33	brain derived neurotrophic factor	Mus musculus	43-47
19917299-4	2010	We report here that ginkgo flavonols quercetin and kaempferol stimulates depression-related signaling pathways involving brain-derived neurotrophic factor BDNF/phosphorylation of cyclic AMP response element binding protein CREB/postsynaptic density proteins PSD95, and reduces amyloid-beta peptide (Abeta) in neurons isolated from double transgenic AD mouse (TgAPPswe/PS1e9).	Flavonols	27-36	brain derived neurotrophic factor	Mus musculus	155-159
20190095-3	2010	We have expressed an Arabidopsis (Arabidopsis thaliana) transcription factor, AtMYB12, in tobacco (Nicotiana tabacum), which resulted in enhanced expression of genes involved in the phenylpropanoid pathway, leading to severalfold higher accumulation of flavonols.	Flavonols	253-262	myb domain protein 12	Arabidopsis thaliana	78-85
21117316-5	2010	The article discusses recent reports on the EpRE-mediated induction of NQO1 (NAD(P)H: quinone oxidoreductase) gene expression by the flavonoids (flavonols, flavones and flavan-3-oles) and the role of pro-oxidant properties of the flavonoids in the mechanism of this induction.	Flavonols	145-154	NAD(P)H quinone dehydrogenase 1	Homo sapiens	71-75
21117316-5	2010	The article discusses recent reports on the EpRE-mediated induction of NQO1 (NAD(P)H: quinone oxidoreductase) gene expression by the flavonoids (flavonols, flavones and flavan-3-oles) and the role of pro-oxidant properties of the flavonoids in the mechanism of this induction.	Flavonols	145-154	crystallin zeta	Homo sapiens	86-108
19433090-3	2009	Nevertheless, other FLS activities must be present, because A. thalianafls1 mutants still accumulate significant amounts of flavonols.	Flavonols	124-133	flavonol synthase 1	Arabidopsis thaliana	20-23
19487249-0	2009	Inhibition of human CYP2B6-catalyzed bupropion hydroxylation by Ginkgo biloba extract: effect of terpene trilactones and flavonols.	Flavonols	121-130	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	20-26
19487249-5	2009	Therefore, we investigated the effect of G. biloba extract and some of its chemical constituents (terpene trilactones and flavonols) on the in vitro catalytic activity of CYP2B6 as assessed by the bupropion hydroxylation assay with recombinant enzyme and hepatic microsomes.	Flavonols	122-131	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	171-177
19617894-11	2009	CONCLUSION: These data show that the flavonols quercetin and kaempferol have higher anti-invasion potency and higher MMP-3 inhibitory activity than isoflavones genistein, genistin and daidzein.	Flavonols	37-46	matrix metallopeptidase 3	Homo sapiens	117-122
19914244-5	2010	Therefore, these flavones and flavonols utilize alternative mechanisms to influence the transcriptional activities of ERRgamma and PGC-1alpha.	Flavonols	30-39	estrogen related receptor gamma	Homo sapiens	118-126
19914244-5	2010	Therefore, these flavones and flavonols utilize alternative mechanisms to influence the transcriptional activities of ERRgamma and PGC-1alpha.	Flavonols	30-39	PPARG coactivator 1 alpha	Homo sapiens	131-141
19741049-5	2009	Transcript analysis of VvMYBF1 throughout grape berry development revealed its expression during flowering and in skins of ripening berries, which correlates with the accumulation of flavonols and expression of VvFLS1.	Flavonols	183-192	R2R3 MYB 12 transcription factor	Vitis vinifera	23-30
19433090-5	2009	This enzyme is therefore likely responsible for the formation of flavonols in the ldox/fls1-2 double mutant.	Flavonols	65-74	leucoanthocyanidin dioxygenase	Arabidopsis thaliana	82-86
19433090-5	2009	This enzyme is therefore likely responsible for the formation of flavonols in the ldox/fls1-2 double mutant.	Flavonols	65-74	flavonol synthase 1	Arabidopsis thaliana	87-91
19433090-6	2009	These double mutant and biochemical data demonstrate for the first time that LDOX is capable of catalyzing the in planta formation of flavonols.	Flavonols	134-143	leucoanthocyanidin dioxygenase	Arabidopsis thaliana	77-81
17869316-4	2008	On the other hand, some flavones such as apigenin, flavonols such as quercetin, and anthraquinones such as emodin, showed notable inhibitory effects on the in vitro activation of AhR induced by the dioxin [2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)].	Flavonols	51-60	aryl hydrocarbon receptor	Homo sapiens	179-182
19244381-0	2009	The flavonols quercetin, kaempferol, and myricetin inhibit hepatocyte growth factor-induced medulloblastoma cell migration.	Flavonols	4-13	hepatocyte growth factor	Homo sapiens	59-83
19244381-3	2009	Using immunoblotting procedures, we observed that the dietary-derived flavonols quercetin, kaempferol, and myricetin inhibited HGF/Met signaling in a medulloblastoma cell line (DAOY), preventing the formation of actin-rich membrane ruffles and resulting in the inhibition of Met-induced cell migration in Boyden chambers.	Flavonols	70-79	hepatocyte growth factor	Homo sapiens	127-130
19074529-0	2009	Mechanism of CYP2C9 inhibition by flavones and flavonols.	Flavonols	47-56	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	13-19
19074529-1	2009	This article describes an in vitro investigation of the inhibition of cytochrome P450 (P450) 2C9 by a series of flavonoids made up of flavones (flavone, 6-hydroxyflavone, 7-hydroxyflavone, chrysin, baicalein, apigenin, luteolin, scutellarein, and wogonin) and flavonols (galangin, fisetin, kaempferol, morin, and quercetin).	Flavonols	260-269	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-96
19020811-2	2009	Since the activity of the other MDR transporter, P-glycoprotein, is sensitive to membrane perturbation, we aimed to check whether the changes in lipid bilayer properties induced by flavones (apigenin, acacetin) and flavonols (morin, myricetin) were related to their MRP1 inhibitory activity.	Flavonols	215-224	ATP binding cassette subfamily B member 1	Homo sapiens	49-63
19129169-6	2009	Flavonols were the most drastically reduced flavonoids following shading and leaf removal treatments, related to the reduced expression of FLAVONOL SYNTHASE 4 and its putative transcriptional regulator MYB12.	Flavonols	0-9	R2R3 MYB 12 transcription factor	Vitis vinifera	202-207
18998159-1	2009	Flavonol synthase (FLS) (EC-number 1.14.11.23), the enzyme that catalyses the conversion of flavonols into dihydroflavonols, is part of the flavonoid biosynthesis pathway.	Flavonols	92-101	flavonol synthase 1	Arabidopsis thaliana	0-17
18998159-1	2009	Flavonol synthase (FLS) (EC-number 1.14.11.23), the enzyme that catalyses the conversion of flavonols into dihydroflavonols, is part of the flavonoid biosynthesis pathway.	Flavonols	92-101	flavonol synthase 1	Arabidopsis thaliana	19-22
18331776-6	2008	It was found that the treatment of OE33 cells with flavones and flavonols caused G2/M arrest through up-regulation of GADD45beta and 14-3-3sigma and down-regulation of cyclin B1 at the mRNA and protein levels, and induced p53-independent mitochondrial-mediated apoptosis through up-regulation of PIG3 and cleavage of caspase-9 and caspase-3.	Flavonols	64-73	growth arrest and DNA damage inducible beta	Homo sapiens	118-144
18643978-3	2008	AtMYB12 is able to induce the expression of additional target genes in tobacco, leading to the accumulation of very high levels of flavonols.	Flavonols	131-140	myb domain protein 12	Arabidopsis thaliana	0-7
18657430-1	2008	Flavanone 3beta-hydroxylase (F3H; EC 1.14.11.9) is a 2-oxoglutarate dependent dioxygenase that catalyzes the synthesis of dihydrokaempferol, the common precursor for three major classes of 3-hydroxy flavonoids, the flavonols, anthocyanins, and proanthocyanidins.	Flavonols	215-224	flavanone 3-hydroxylase	Arabidopsis thaliana	0-27
18657430-1	2008	Flavanone 3beta-hydroxylase (F3H; EC 1.14.11.9) is a 2-oxoglutarate dependent dioxygenase that catalyzes the synthesis of dihydrokaempferol, the common precursor for three major classes of 3-hydroxy flavonoids, the flavonols, anthocyanins, and proanthocyanidins.	Flavonols	215-224	flavanone 3-hydroxylase	Arabidopsis thaliana	29-32
18700775-5	2008	Of the compounds investigated, the majority of flavones, flavonols, flavanones, and isoflavones were bound to betaLG.	Flavonols	57-66	beta-lactoglobulin	Bos taurus	110-116
18645237-0	2008	Structural evidence for the inhibition of grape dihydroflavonol 4-reductase by flavonols.	Flavonols	79-88	dihydroflavonol 4-reductase	Vitis vinifera	48-75
18645237-8	2008	The results suggest that flavonols could be inhibitors of the activity of DFR towards dihydroflavonols.	Flavonols	25-34	dihydroflavonol 4-reductase	Vitis vinifera	74-77
18467451-2	2008	This apparent redundancy suggests the possibility that Arabidopsis uses multiple isoforms of FLS with different substrate specificities to mediate the production of the flavonols, quercetin and kaempferol, in a tissue-specific and inducible manner.	Flavonols	169-178	flavonol synthase 1	Arabidopsis thaliana	93-96
18718912-5	2008	Application of nanomolar concentrations of flavonols to pin2 roots is sufficient to partially restore root gravitropism.	Flavonols	43-52	telomeric repeat binding factor 1	Homo sapiens	56-60
19008647-3	2008	To find activators or inhibitors to SIRT1, we examined thirty-six polyphenols, including stilbenes, chalcones, flavanones, and flavonols, with the SIRT1 deacetylase activity assay using the acetylated peptide of p53 as a substrate.	Flavonols	127-136	sirtuin 1	Homo sapiens	147-152
18507367-2	2008	Four flavonols and three flavones, out of the 19 flavonoids tested, exhibited IC50 values less than 100 microM against human salivary alpha-amylase activity.	Flavonols	5-14	amylase alpha 1A	Homo sapiens	125-147
18331776-6	2008	It was found that the treatment of OE33 cells with flavones and flavonols caused G2/M arrest through up-regulation of GADD45beta and 14-3-3sigma and down-regulation of cyclin B1 at the mRNA and protein levels, and induced p53-independent mitochondrial-mediated apoptosis through up-regulation of PIG3 and cleavage of caspase-9 and caspase-3.	Flavonols	64-73	cyclin B1	Homo sapiens	168-177
18331776-6	2008	It was found that the treatment of OE33 cells with flavones and flavonols caused G2/M arrest through up-regulation of GADD45beta and 14-3-3sigma and down-regulation of cyclin B1 at the mRNA and protein levels, and induced p53-independent mitochondrial-mediated apoptosis through up-regulation of PIG3 and cleavage of caspase-9 and caspase-3.	Flavonols	64-73	tumor protein p53	Homo sapiens	222-225
18331776-6	2008	It was found that the treatment of OE33 cells with flavones and flavonols caused G2/M arrest through up-regulation of GADD45beta and 14-3-3sigma and down-regulation of cyclin B1 at the mRNA and protein levels, and induced p53-independent mitochondrial-mediated apoptosis through up-regulation of PIG3 and cleavage of caspase-9 and caspase-3.	Flavonols	64-73	tumor protein p53 inducible protein 3	Homo sapiens	296-300
18331776-6	2008	It was found that the treatment of OE33 cells with flavones and flavonols caused G2/M arrest through up-regulation of GADD45beta and 14-3-3sigma and down-regulation of cyclin B1 at the mRNA and protein levels, and induced p53-independent mitochondrial-mediated apoptosis through up-regulation of PIG3 and cleavage of caspase-9 and caspase-3.	Flavonols	64-73	caspase 9	Homo sapiens	317-326
18331776-6	2008	It was found that the treatment of OE33 cells with flavones and flavonols caused G2/M arrest through up-regulation of GADD45beta and 14-3-3sigma and down-regulation of cyclin B1 at the mRNA and protein levels, and induced p53-independent mitochondrial-mediated apoptosis through up-regulation of PIG3 and cleavage of caspase-9 and caspase-3.	Flavonols	64-73	caspase 3	Homo sapiens	331-340
18567791-3	2008	Flavonols in the cell are glycosylated, and the repressor of lrx1 (rol1) mutants of Arabidopsis thaliana, affected in rhamnose biosynthesis, have a modified flavonol glycosylation profile.	Flavonols	0-9	leucine-rich repeat/extensin 1	Arabidopsis thaliana	61-65
18567791-3	2008	Flavonols in the cell are glycosylated, and the repressor of lrx1 (rol1) mutants of Arabidopsis thaliana, affected in rhamnose biosynthesis, have a modified flavonol glycosylation profile.	Flavonols	0-9	rhamnose biosynthesis 1	Arabidopsis thaliana	67-71
18414005-0	2008	Accumulation of flavonols in response to ultraviolet-B irradiation in soybean is related to induction of flavanone 3-beta-hydroxylase and flavonol synthase.	Flavonols	16-25	flavonol synthase	Glycine max	138-155
18295609-0	2008	Flavonols and flavones as BACE-1 inhibitors: structure-activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features.	Flavonols	0-9	beta-secretase 1	Homo sapiens	26-32
18473744-5	2008	Studies on these isoforms with a range of environmental chemicals and dietary components have shown that SULT 1A1 is significantly inhibited by flavonoids; all flavones and flavonols with a 3",4"-dihydroxy motif had an IC(50) of < 100 nm against 3 microM 4-nitrophenol as the standard substrate.	Flavonols	173-182	sulfotransferase family 1A member 1	Homo sapiens	105-113
18333618-0	2008	Influence of B-ring hydroxylation on interactions of flavonols with bovine serum albumin.	Flavonols	53-62	albumin	Homo sapiens	75-88
18321380-4	2008	Based on enzyme studies, the recombinant UGT is a 7-O-glycosyltransferase whose natural substrates include both anthocyanidins and flavonols such as kaempferol and quercetin.	Flavonols	131-140	hydroquinone glucosyltransferase-like	Solanum tuberosum	54-73
17886198-3	2007	Against recombinant human MMP-1, flavonols such as quercetin and kaempferol were strong inhibitors with IC50 values of 39.6 and 43.7 microM, respectively, while flavones such as apigenin and wogonin showed only weak inhibitory activity.	Flavonols	33-42	matrix metallopeptidase 1	Homo sapiens	26-31
17693661-5	2007	Here we demonstrated that 3,3",4",5,5",7-hexahydroxyflavone (myricetin), one of the major flavonols in red wine, is a novel inhibitor of MEK1 activity and transformation of JB6 P+ mouse epidermal cells.	Flavonols	90-99	mitogen-activated protein kinase kinase 1	Homo sapiens	137-141
17384531-6	2007	Analyses of structure-activity relationships of 45 flavones, flavonols and their related compounds showed that luteolin, ayanin, apigenin and fisetin were the strongest inhibitors of IL-4 production with an IC(50) value of 2-5 microM and determined a fundamental structure for the inhibitory activity.	Flavonols	61-70	interleukin 4	Mus musculus	183-187
17141727-0	2007	Differential effects of flavonols on inactivation of alpha1-antitrypsin induced by hypohalous acids and the myeloperoxidase-hydrogen peroxide-halide system.	Flavonols	24-33	serpin family A member 1	Homo sapiens	53-71
17601828-7	2007	TT12 does not transport glycosylated flavonols and procyanidin dimers, and a direct transport activity for catechin-3-O-glucoside, a glucosylated flavan-3-ol, was not detectable.	Flavonols	37-46	MATE efflux family protein	Arabidopsis thaliana	0-4
17601828-8	2007	However, catechin-3-O-glucoside inhibited TT12-mediated transport of cyanidin-3-O-glucoside in a dose-dependent manner, while flavan-3-ol aglycones and glycosylated flavonols had no effect on anthocyanin transport.	Flavonols	165-174	MATE efflux family protein	Arabidopsis thaliana	42-46
17141727-3	2007	The flavonols rutin, quercetin, myricetin, and kaempferol inhibited the inactivation of alpha1-antitrypsin by HOCl and HOBr with rutin having the most pronounced effect.	Flavonols	4-13	serpin family A member 1	Homo sapiens	88-106
17268053-4	2007	On the other hand, flavone and flavonols such as rutin (a 3-glycosidic flavone), quercitrin (a 3-glycosidic flavonol), myricetin, and kaempferol (flavonols), respectively, lowered the CL intensity to a greater extent at low concentrations (<0.1 microM) when catalase was present than when catalase was absent, indicating that these flavonoids activate catalase.	Flavonols	31-40	catalase	Homo sapiens	261-269
17268053-4	2007	On the other hand, flavone and flavonols such as rutin (a 3-glycosidic flavone), quercitrin (a 3-glycosidic flavonol), myricetin, and kaempferol (flavonols), respectively, lowered the CL intensity to a greater extent at low concentrations (<0.1 microM) when catalase was present than when catalase was absent, indicating that these flavonoids activate catalase.	Flavonols	31-40	catalase	Homo sapiens	292-300
17268053-4	2007	On the other hand, flavone and flavonols such as rutin (a 3-glycosidic flavone), quercitrin (a 3-glycosidic flavonol), myricetin, and kaempferol (flavonols), respectively, lowered the CL intensity to a greater extent at low concentrations (<0.1 microM) when catalase was present than when catalase was absent, indicating that these flavonoids activate catalase.	Flavonols	31-40	catalase	Homo sapiens	292-300
17172639-3	2007	Robust inhibition of glucose and fructose transport by GLUT2 expressed in Xenopus laevis oocytes was produced by the flavonols myricetin, fisetin, the widely consumed flavonoid quercetin, and its glucoside precursor isoquercitrin [corrected].	Flavonols	117-126	solute carrier family 2 member 2 S homeolog	Xenopus laevis	55-60
15912140-0	2005	Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells.	Flavonols	0-9	protein kinase C theta	Homo sapiens	89-111
17635218-5	2007	Moreover, tapetum-specific overexpression of AtDOF4;2 led to pollen grains devoid of flavonols.	Flavonols	85-94	Dof-type zinc finger domain-containing protein	Arabidopsis thaliana	45-53
17083738-9	2006	Most interestingly was the opposite temporal fluctuation in transcript abundance between early responsive genes in defense (CHS and IFS1) and F3H, the gene encoding a pivotal enzyme in the synthesis of anthocyanins, proanthocyanidins and flavonols.	Flavonols	238-247	isoflavone synthase 1	Glycine max	132-136
17083738-9	2006	Most interestingly was the opposite temporal fluctuation in transcript abundance between early responsive genes in defense (CHS and IFS1) and F3H, the gene encoding a pivotal enzyme in the synthesis of anthocyanins, proanthocyanidins and flavonols.	Flavonols	238-247	flavanone 3-hydroxylase	Glycine max	142-145
16787048-12	2006	It is possible that an absorption mechanism other than the SGLT1 is involved, which has a structural preference toward flavonols.	Flavonols	119-128	solute carrier family 5 (sodium/glucose cotransporter), member 1	Mus musculus	59-64
16169200-5	2006	These flavonols at approximately 0.5 LD50 doses suppressed the vascular endothelial growth factor (VEGF)-stimulated HUVEC tubular structure formation by: M (47%) > Q (37%) > K (15%) > G (14%), which was not linearly associated with their numbers of -OH moieties.	Flavonols	6-15	vascular endothelial growth factor A	Homo sapiens	63-97
16169200-5	2006	These flavonols at approximately 0.5 LD50 doses suppressed the vascular endothelial growth factor (VEGF)-stimulated HUVEC tubular structure formation by: M (47%) > Q (37%) > K (15%) > G (14%), which was not linearly associated with their numbers of -OH moieties.	Flavonols	6-15	vascular endothelial growth factor A	Homo sapiens	99-103
16249367-2	2006	We have synthesized a new beta-lactam with an N-linked galloyl moiety, the latter identified as strategic in conferring anti-LE properties to some flavonols.	Flavonols	147-156	elastase, neutrophil expressed	Homo sapiens	125-127
16358292-1	2006	Common substitution positions of flavonols are at C-5 and C-7; 6-substituted flavonol derivatives are rarely found in natural sources.	Flavonols	33-42	complement C5	Homo sapiens	50-53
16358292-1	2006	Common substitution positions of flavonols are at C-5 and C-7; 6-substituted flavonol derivatives are rarely found in natural sources.	Flavonols	33-42	complement C7	Homo sapiens	58-61
16434028-8	2006	In RAW264.7 cells, a monocyte/macrophage precursor for osteoclasts, both kaempferol and quercetin dose-dependently inhibited the receptor activator of NF-kappaB ligand (RANKL)-induced immediate-early oncogene c-fos expression at 6 h. After 3-5 days, both flavonols robustly inhibited RANKL-induced expression of the osteoclastic differentiation markers, RANK and calcitonin receptor.	Flavonols	255-264	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	129-167
16434028-8	2006	In RAW264.7 cells, a monocyte/macrophage precursor for osteoclasts, both kaempferol and quercetin dose-dependently inhibited the receptor activator of NF-kappaB ligand (RANKL)-induced immediate-early oncogene c-fos expression at 6 h. After 3-5 days, both flavonols robustly inhibited RANKL-induced expression of the osteoclastic differentiation markers, RANK and calcitonin receptor.	Flavonols	255-264	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	169-174
16434028-9	2006	Consistent with down regulation of these osteoclastic differentiation markers, both flavonols strongly attenuated the RANKL-induced formation of multinucleated osteoclasts.	Flavonols	84-93	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	118-123
15912140-8	2005	These flavonols suppressed intracellular calcium ion elevations in a dose-response manner, with morin being the weakest; they also inhibited phosphorylation of the calcium-insensitive protein kinase C theta (PKC theta).	Flavonols	6-15	protein kinase C theta	Homo sapiens	184-206
15912140-8	2005	These flavonols suppressed intracellular calcium ion elevations in a dose-response manner, with morin being the weakest; they also inhibited phosphorylation of the calcium-insensitive protein kinase C theta (PKC theta).	Flavonols	6-15	protein kinase C theta	Homo sapiens	208-217
15821875-1	2005	Chalcone synthase (CHS), chalcone flavanone isomerase (CFI), flavanone 3-hydroxylase (F3H) and flavonol synthase (FLS) catalyze successive steps in the biosynthetic pathway leading to the production of flavonols.	Flavonols	202-211	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	25-53
15832817-5	2005	Thus, flavonols only inhibited transcription factor AP-1 activation, whereas isoflavones suppressed the DNA binding activation of NF-kappaB and C/EBPbeta.	Flavonols	6-15	jun proto-oncogene	Mus musculus	52-56
15688188-9	2005	Both flavonols increased nuclear ERbeta protein and decreased ERalpha protein of osteoclast progenitors.	Flavonols	5-14	estrogen receptor 2	Homo sapiens	33-39
15688188-9	2005	Both flavonols increased nuclear ERbeta protein and decreased ERalpha protein of osteoclast progenitors.	Flavonols	5-14	estrogen receptor 1	Homo sapiens	62-69
15688188-12	2005	Thus, the anti-resorbing properties of flavonols are mainly mediated by ER proteins through the inhibition of RANK protein or the activation of caspases.	Flavonols	39-48	caspase 8	Homo sapiens	144-152
15828450-2	2005	This study demonstrates that some putative flavonoids, i.e., flavonols (quercetin and kaempferol) and isoflavones (genistein and daidzein) markedly increase the sensitivity of the multidrug-resistant human cervical carcinoma KB-V1 cells (high Pgp expression) to vinblastine and paclitaxel dose-dependently, and also decrease the relative resistance of these anti-cancer-drugs in KB-V1 cells.	Flavonols	61-70	ATP binding cassette subfamily B member 1	Homo sapiens	243-246
15828450-5	2005	The flavonols increased the inhibitory effectiveness of Pgp activity in MDR KB-V1 cells more than isoflavones.	Flavonols	4-13	ATP binding cassette subfamily B member 1	Homo sapiens	56-59
15828450-6	2005	Only treatment with flavonols up to 48 h was able to significantly decrease the Pgp expression in a dose-dependent manner in KB-V1 cells.	Flavonols	20-29	ATP binding cassette subfamily B member 1	Homo sapiens	80-83
15828450-7	2005	These findings provide evidence that flavonols reduced Pgp expression and function resulting in the inhibition of Pgp activity, but isoflavones modulated intracellular drug levels by inhibiting Pgp function with no effect on Pgp expression.	Flavonols	37-46	ATP binding cassette subfamily B member 1	Homo sapiens	55-58
15828450-7	2005	These findings provide evidence that flavonols reduced Pgp expression and function resulting in the inhibition of Pgp activity, but isoflavones modulated intracellular drug levels by inhibiting Pgp function with no effect on Pgp expression.	Flavonols	37-46	ATP binding cassette subfamily B member 1	Homo sapiens	114-117
15828450-7	2005	These findings provide evidence that flavonols reduced Pgp expression and function resulting in the inhibition of Pgp activity, but isoflavones modulated intracellular drug levels by inhibiting Pgp function with no effect on Pgp expression.	Flavonols	37-46	ATP binding cassette subfamily B member 1	Homo sapiens	114-117
15828450-7	2005	These findings provide evidence that flavonols reduced Pgp expression and function resulting in the inhibition of Pgp activity, but isoflavones modulated intracellular drug levels by inhibiting Pgp function with no effect on Pgp expression.	Flavonols	37-46	ATP binding cassette subfamily B member 1	Homo sapiens	114-117
15923334-8	2005	Quantitative real time reverse transcription-PCR using these mutant plants showed MYB12 to be a transcriptional regulator of CHALCONE SYNTHASE and FLAVONOL SYNTHASE in planta, the gene products of which are indispensable for the biosynthesis of flavonols.	Flavonols	245-254	myb domain protein 12	Arabidopsis thaliana	82-87
15923334-8	2005	Quantitative real time reverse transcription-PCR using these mutant plants showed MYB12 to be a transcriptional regulator of CHALCONE SYNTHASE and FLAVONOL SYNTHASE in planta, the gene products of which are indispensable for the biosynthesis of flavonols.	Flavonols	245-254	Chalcone and stilbene synthase family protein	Arabidopsis thaliana	125-142
15914907-2	2005	Our previous study found that flavones and flavonols at dietary levels suppress AhR transformation.	Flavonols	43-52	aryl-hydrocarbon receptor	Mus musculus	80-83
15832299-5	2005	While for catechin and epicatechin the first ionizable OH group occurs in ring 1 and the second ionizable group in ring 2, in flavonols the first deprotonation occurs in ring 2 and the second in ring 1.	Flavonols	126-135	ring finger protein 2	Homo sapiens	115-121
15832299-5	2005	While for catechin and epicatechin the first ionizable OH group occurs in ring 1 and the second ionizable group in ring 2, in flavonols the first deprotonation occurs in ring 2 and the second in ring 1.	Flavonols	126-135	ring finger protein 2	Homo sapiens	170-176
15832299-5	2005	While for catechin and epicatechin the first ionizable OH group occurs in ring 1 and the second ionizable group in ring 2, in flavonols the first deprotonation occurs in ring 2 and the second in ring 1.	Flavonols	126-135	ring finger protein 1	Homo sapiens	195-201
15821875-1	2005	Chalcone synthase (CHS), chalcone flavanone isomerase (CFI), flavanone 3-hydroxylase (F3H) and flavonol synthase (FLS) catalyze successive steps in the biosynthetic pathway leading to the production of flavonols.	Flavonols	202-211	Chalcone-flavanone isomerase family protein	Arabidopsis thaliana	55-58
15821875-1	2005	Chalcone synthase (CHS), chalcone flavanone isomerase (CFI), flavanone 3-hydroxylase (F3H) and flavonol synthase (FLS) catalyze successive steps in the biosynthetic pathway leading to the production of flavonols.	Flavonols	202-211	flavanone 3-hydroxylase	Arabidopsis thaliana	61-84
15821875-1	2005	Chalcone synthase (CHS), chalcone flavanone isomerase (CFI), flavanone 3-hydroxylase (F3H) and flavonol synthase (FLS) catalyze successive steps in the biosynthetic pathway leading to the production of flavonols.	Flavonols	202-211	flavanone 3-hydroxylase	Arabidopsis thaliana	86-89
15821875-1	2005	Chalcone synthase (CHS), chalcone flavanone isomerase (CFI), flavanone 3-hydroxylase (F3H) and flavonol synthase (FLS) catalyze successive steps in the biosynthetic pathway leading to the production of flavonols.	Flavonols	202-211	flavonol synthase 1	Arabidopsis thaliana	95-112
15043421-0	2004	Effects of natural flavones and flavonols on the kinase activity of Cdk5.	Flavonols	32-41	cyclin dependent kinase 5	Homo sapiens	68-72
15013846-0	2004	Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway.	Flavonols	42-51	alkaline phosphatase, placental	Homo sapiens	80-100
15013846-0	2004	Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway.	Flavonols	42-51	mitogen-activated protein kinase 1	Homo sapiens	145-148
15013846-3	2004	In this study, we investigated the in vitro effect of two widespread flavonols, quercetin and kaempferol, on alkaline phosphatase (ALP) activity in MG-63 cultured human osteoblasts.	Flavonols	69-78	alkaline phosphatase, placental	Homo sapiens	109-129
15013846-3	2004	In this study, we investigated the in vitro effect of two widespread flavonols, quercetin and kaempferol, on alkaline phosphatase (ALP) activity in MG-63 cultured human osteoblasts.	Flavonols	69-78	alkaline phosphatase, placental	Homo sapiens	131-134
15013846-4	2004	We found that both flavonols significantly increased ALP activity.	Flavonols	19-28	alkaline phosphatase, placental	Homo sapiens	53-56
15013846-6	2004	Western blot studies confirmed that ERK is rapidly activated in cells treated by both flavonols.	Flavonols	86-95	mitogen-activated protein kinase 1	Homo sapiens	36-39
15013846-8	2004	The data presented in this study support the conclusion that, in MG-63 osteoblasts (i) the increase in ALP activity by flavonols involves a rapid stimulation of ERK activation but also involves the ER, and that (ii) the activation of ERK by flavonols occurs most likely downstream of the ERs activation.	Flavonols	119-128	alkaline phosphatase, placental	Homo sapiens	103-106
15013846-8	2004	The data presented in this study support the conclusion that, in MG-63 osteoblasts (i) the increase in ALP activity by flavonols involves a rapid stimulation of ERK activation but also involves the ER, and that (ii) the activation of ERK by flavonols occurs most likely downstream of the ERs activation.	Flavonols	119-128	mitogen-activated protein kinase 1	Homo sapiens	161-164
15013846-8	2004	The data presented in this study support the conclusion that, in MG-63 osteoblasts (i) the increase in ALP activity by flavonols involves a rapid stimulation of ERK activation but also involves the ER, and that (ii) the activation of ERK by flavonols occurs most likely downstream of the ERs activation.	Flavonols	119-128	mitogen-activated protein kinase 1	Homo sapiens	234-237
15013846-8	2004	The data presented in this study support the conclusion that, in MG-63 osteoblasts (i) the increase in ALP activity by flavonols involves a rapid stimulation of ERK activation but also involves the ER, and that (ii) the activation of ERK by flavonols occurs most likely downstream of the ERs activation.	Flavonols	241-250	alkaline phosphatase, placental	Homo sapiens	103-106
15013846-8	2004	The data presented in this study support the conclusion that, in MG-63 osteoblasts (i) the increase in ALP activity by flavonols involves a rapid stimulation of ERK activation but also involves the ER, and that (ii) the activation of ERK by flavonols occurs most likely downstream of the ERs activation.	Flavonols	241-250	mitogen-activated protein kinase 1	Homo sapiens	234-237
14969565-4	2004	A red wine fraction rich in polymeric flavanols and a white wine one rich in phenolic acids, flavonols, and tyrosol strongly lowered Hsp27 levels.	Flavonols	93-102	heat shock protein family B (small) member 1	Homo sapiens	133-138
15072439-10	2004	Certain natural flavonols (e.g., kaempferol, quercetin, and galangin) are potent stimulators of the Pgp-mediated efflux of 7,12-dimethylbenz(a)-anthracene (a carcinogen).	Flavonols	16-25	ATP binding cassette subfamily B member 1	Homo sapiens	100-103
15630228-2	2004	We have previously demonstrated that certain natural flavones and flavonols at the dietary levels suppress AhR transformation.	Flavonols	66-75	aryl-hydrocarbon receptor	Mus musculus	107-110
14646171-5	2003	These results suggested that the impairment of mast cell degranulation by several flavonoids classified into flavones and flavonols might be mediated via inhibition of the intracellular activation of Syk.	Flavonols	122-131	spleen associated tyrosine kinase	Homo sapiens	200-203
14646185-4	2003	Among them, flavones, flavonols, anthraquinones, piperine, coumestrol, brevifolincarboxylic acid, and resveratrol showed marked inhibitory effects on AhR-based bioassay activation by TCDD, and their effects were dose dependent.	Flavonols	22-31	aryl hydrocarbon receptor	Homo sapiens	150-153
14750022-18	2003	However, if the C-3 hydroxy group on the C-ring of flavonols, but not flavones which lack this hydroxy group, is methoxylated, the relaxant effects may increase.	Flavonols	51-60	complement C3	Cavia porcellus	16-19
14977446-3	2003	Flavones, flavonols, and chalcone are the most potent inhibitors of production of TNF-alpha.	Flavonols	10-19	tumor necrosis factor	Mus musculus	82-91