PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25888628-8	2015	This proof-of-concept study with dTALEs for locus-specific epigenomic manipulation validates the selected CpG methylation of CRMP4 gene as an independent biomarker for diagnosis and prognosis of prostate cancer metastasis and opens up a novel avenue for mechanistic research on cancer biology.	dtales	33-39	dihydropyrimidinase like 3	Homo sapiens	125-130
24667606-3	2014	Here we tested whether dTALEs can be used to target genes whose expression is controlled by Wnt/beta-catenin signaling.	dtales	23-29	catenin beta 1	Homo sapiens	96-108
24667606-9	2014	The TALE-SIDs repressed AXIN2 and MYC expression in these cells, which suggests that dTALEs could offer an effective therapeutic strategy for the treatment of colorectal cancer.	dtales	85-91	axin 2	Homo sapiens	24-29
24667606-9	2014	The TALE-SIDs repressed AXIN2 and MYC expression in these cells, which suggests that dTALEs could offer an effective therapeutic strategy for the treatment of colorectal cancer.	dtales	85-91	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	34-37
22387464-6	2012	In contrast to their similar in vitro properties, transcriptional activation of oct4 by these distinct dTALEs varied up to 25-fold.	dtales	103-109	POU class 5 homeobox 1	Homo sapiens	80-84
22387464-7	2012	While dTALEs efficiently upregulated transcription of the active oct4 promoter in embryonic stem cells (ESCs) they failed to activate the silenced oct4 promoter in ESC-derived neural stem cells (NSCs), indicating that as for endogenous transcription factors also dTALE activity is limited by repressive epigenetic mechanisms.	dtales	6-12	POU class 5 homeobox 1	Homo sapiens	65-69
22387464-9	2012	Notably, demethylation of the oct4 promoter occurred only if chemical inhibitors and dTALEs were applied together but not upon treatment with inhibitors or dTALEs only.	dtales	85-91	POU class 5 homeobox 1	Homo sapiens	30-34
22387464-9	2012	Notably, demethylation of the oct4 promoter occurred only if chemical inhibitors and dTALEs were applied together but not upon treatment with inhibitors or dTALEs only.	dtales	156-162	POU class 5 homeobox 1	Homo sapiens	30-34