PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 27722727-6 2016 Additionally, an interlayer expanded siliceous zeolite SSA-1 (IEZ-SSA-1) was also successfully prepared by silylation using trichloro(methyl)silane under acidic conditions. trichloromethyl free radical 124-141 tripartite motif containing 21 Homo sapiens 55-60 30368867-7 2018 But the heme oxygenase-1 (HO-1) activator hemin attenuated the inhibitory effects of bortezomib on APRIL and CCL3. trichloromethyl free radical 109-113 heme oxygenase 1 Mus musculus 26-30 29902765-4 2018 Among these chemical hepatotoxins, CCl4 are responsible for the trichloromethyl radical resulting from biotransformation of the liver. trichloromethyl free radical 64-87 C-C motif chemokine ligand 4 Rattus norvegicus 35-39 27722727-6 2016 Additionally, an interlayer expanded siliceous zeolite SSA-1 (IEZ-SSA-1) was also successfully prepared by silylation using trichloro(methyl)silane under acidic conditions. trichloromethyl free radical 124-141 tripartite motif containing 21 Homo sapiens 62-71 14713368-1 2003 Carbon tetrachloride (CCl4) is metabolized by cytochrome P450 to form a reactive trichloromethyl radical that triggers a chain of lipid peroxidation. trichloromethyl free radical 81-104 C-C motif chemokine ligand 4 Rattus norvegicus 22-26 25164482-2 2014 It was found that under anaerobic conditions, the substrate CCl4 might undergo one or two subsequent one-electron reductions to generate different reactive metabolites, trichloromethyl radical ( CCl3) and dichlorocarbene (:CCl2) respectively. trichloromethyl free radical 169-192 C-C motif chemokine ligand 4 Homo sapiens 60-64 25164482-2 2014 It was found that under anaerobic conditions, the substrate CCl4 might undergo one or two subsequent one-electron reductions to generate different reactive metabolites, trichloromethyl radical ( CCl3) and dichlorocarbene (:CCl2) respectively. trichloromethyl free radical 169-192 C-C motif chemokine ligand 3 Homo sapiens 195-199 25164482-2 2014 It was found that under anaerobic conditions, the substrate CCl4 might undergo one or two subsequent one-electron reductions to generate different reactive metabolites, trichloromethyl radical ( CCl3) and dichlorocarbene (:CCl2) respectively. trichloromethyl free radical 169-192 C-C motif chemokine ligand 2 Homo sapiens 223-227 24639355-4 2014 Only MIP-1 chemokines, including Ccl3 and Ccl4, displayed peak expression 24 h after light exposure, and peaked earlier than the other chemokines. trichloromethyl free radical 33-37 transportin 1 Mus musculus 5-10 24639355-10 2014 The deficiency of Ccl3 also attenuated the severity of retinal degeneration in Mertk(-/-) mice. trichloromethyl free radical 18-22 MER proto-oncogene tyrosine kinase Mus musculus 79-84 22705105-5 2012 Collectively, these results identify the IL-15-dependent subset of intestinal NKp46(+) cells as an important source of CCL3, which can amplify intestinal inflammation via the recruitment of CCR1(+) inflammatory monocytes. trichloromethyl free radical 119-123 interleukin 15 Homo sapiens 41-46 22705105-5 2012 Collectively, these results identify the IL-15-dependent subset of intestinal NKp46(+) cells as an important source of CCL3, which can amplify intestinal inflammation via the recruitment of CCR1(+) inflammatory monocytes. trichloromethyl free radical 119-123 natural cytotoxicity triggering receptor 1 Homo sapiens 78-83 19496777-2 2009 Carbon tetrachloride (CCl4) treatment to rats has been more susceptible to peroxidative damage through production of reactive metabolites, namely trichloromethyl-free radicals (CCl3 and/or CCl3 OO ) as measured by thiobarbituric acid reactive species. trichloromethyl free radical 146-175 C-C motif chemokine ligand 4 Rattus norvegicus 22-26 19496777-2 2009 Carbon tetrachloride (CCl4) treatment to rats has been more susceptible to peroxidative damage through production of reactive metabolites, namely trichloromethyl-free radicals (CCl3 and/or CCl3 OO ) as measured by thiobarbituric acid reactive species. trichloromethyl free radical 146-175 C-C motif chemokine ligand 3 Rattus norvegicus 177-181 17645873-5 2007 CCL3 (D26A), CCL4, CCL5, CCL8 and CCL13 were able to stimulate Ca(2+) mobilisation through CCR5, although CCL3 (D26A) and CCL5 exhibited biphasic concentration-response curves. trichloromethyl free radical 106-110 C-C motif chemokine 5 Cricetulus griseus 19-23 20821823-2 2010 Carbon tetrachloride (CCl4) is known to induce hepatotoxicity after being metabolized to the highly reactive trichloromethyl free radical and its peroxy radical. trichloromethyl free radical 109-137 chemokine (C-C motif) ligand 4 Mus musculus 22-26 19336974-1 2009 Carbon tetrachloride (CCl4) is well known to induce hepatotoxicity after being metabolized to trichloromethyl free radical ((. trichloromethyl free radical 94-122 C-C motif chemokine ligand 4 Rattus norvegicus 22-26 17645873-5 2007 CCL3 (D26A), CCL4, CCL5, CCL8 and CCL13 were able to stimulate Ca(2+) mobilisation through CCR5, although CCL3 (D26A) and CCL5 exhibited biphasic concentration-response curves. trichloromethyl free radical 0-4 C-C chemokine receptor type 5 Cricetulus griseus 91-95 17645873-5 2007 CCL3 (D26A), CCL4, CCL5, CCL8 and CCL13 were able to stimulate Ca(2+) mobilisation through CCR5, although CCL3 (D26A) and CCL5 exhibited biphasic concentration-response curves. trichloromethyl free radical 0-4 C-C motif chemokine 5 Cricetulus griseus 122-126 16015368-0 2005 Variants of CCR5, which are permissive for HIV-1 infection, show distinct functional responses to CCL3, CCL4 and CCL5. trichloromethyl free radical 98-102 C-C motif chemokine receptor 5 Homo sapiens 12-16 15707062-4 2005 The potential energies associated with fragmentation of the carbon tetrachloride anion radical (CCl4-) into a trichloromethyl radical (CCl3) and a chloride ion (Cl-) were explored as a function of the carbon-chlorine bond distance during cleavage. trichloromethyl free radical 110-133 C-C motif chemokine ligand 4 Homo sapiens 96-100 15707062-4 2005 The potential energies associated with fragmentation of the carbon tetrachloride anion radical (CCl4-) into a trichloromethyl radical (CCl3) and a chloride ion (Cl-) were explored as a function of the carbon-chlorine bond distance during cleavage. trichloromethyl free radical 110-133 C-C motif chemokine ligand 3 Homo sapiens 135-139 9641253-1 1998 It has been proposed that the C-phenyl-N-tert-butylnitrone/trichloromethyl radical adduct (PBN/.CCl3) is metabolized to either the C-phenyl-N-tert-butylnitrone/carbon dioxide anion radical adduct (PBN/.CO2-) or the glutathione (GSH) and CCl4-dependent PBN radical adduct (PBN/[GSH-.CCl3]). trichloromethyl free radical 59-82 C-C motif chemokine ligand 3 Homo sapiens 96-100 12634395-2 2003 Here, we show that IL-7 induced a dose-dependent production of CCL3 (MIP-1alpha), CCL4 (MIP-1beta), and CCL5 (RANTES) in peripheral blood mononuclear cells (PBMC), ex vivo tonsil lymphoid tissue of HIV(-) individuals, and PBMC from HIV(+) individuals, suggesting that IL-7 may regulate beta-chemokine production in vivo. trichloromethyl free radical 63-67 interleukin 7 Homo sapiens 19-23 12875978-3 2003 We found an association between KC and MIP-1alpha (CCL3) production and neutrophil infiltration in the lungs of Pb-infected mice during the early acute phase of infection. trichloromethyl free radical 51-55 chemokine (C-C motif) ligand 3 Mus musculus 39-49 9641253-1 1998 It has been proposed that the C-phenyl-N-tert-butylnitrone/trichloromethyl radical adduct (PBN/.CCl3) is metabolized to either the C-phenyl-N-tert-butylnitrone/carbon dioxide anion radical adduct (PBN/.CO2-) or the glutathione (GSH) and CCl4-dependent PBN radical adduct (PBN/[GSH-.CCl3]). trichloromethyl free radical 59-82 C-C motif chemokine ligand 4 Homo sapiens 237-241 9641253-1 1998 It has been proposed that the C-phenyl-N-tert-butylnitrone/trichloromethyl radical adduct (PBN/.CCl3) is metabolized to either the C-phenyl-N-tert-butylnitrone/carbon dioxide anion radical adduct (PBN/.CO2-) or the glutathione (GSH) and CCl4-dependent PBN radical adduct (PBN/[GSH-.CCl3]). trichloromethyl free radical 59-82 C-C motif chemokine ligand 3 Homo sapiens 282-286 18472838-6 1997 Supposedly the free radicals derived from CCl(4)-mainly trichloromethyl-could induce the prompt reaction of SIRS and the release of sPLA(2) as well as the formation of KPGF. trichloromethyl free radical 56-71 phospholipase A2 group IIA Rattus norvegicus 132-138 9438234-1 1997 Carbon tetrachloride (CCl4) is metabolized to trichloromethyl radical and induces liver injury with elevated serum transaminase and increased hepatic triacylglycerols (TG). trichloromethyl free radical 46-69 chemokine (C-C motif) ligand 4 Mus musculus 22-26 7834057-4 1994 Consistently, in DHEA-pretreated microsomes the protein covalent binding of the trichloromethyl radical (CCl3 degrees), is similar to that of not supplemented microsomes treated with CCl4. trichloromethyl free radical 80-103 C-C motif chemokine ligand 3 Rattus norvegicus 105-109 24214427-1 1995 Electron ionization and thermospray were used in conjunction with tandem mass spectrometry methods to identify trichloromethyl/C-phenyl-N-tert-butyl nitrone (PBN) spin adducts produced in rat liver microsomal dispersions that had been treated with reduced nicotinamide adenine dinucleotide phosphate (NADPH)-generating system and BrCCl3 (or CCl4). trichloromethyl free radical 111-126 C-C motif chemokine ligand 4 Rattus norvegicus 341-345 7699199-0 1994 Study of reproducibility of spin trapping results in the use of C-phenyl-N-tert-butyl nitrone (PBN) for trichloromethyl radical detection in CCl4 metabolism by rat liver microsomal dispersions. trichloromethyl free radical 104-127 C-C motif chemokine ligand 4 Rattus norvegicus 141-145 7725927-2 1995 Injury is mediated by reactive free radicals, mainly-CCl3 (trichloromethyl). trichloromethyl free radical 59-74 C-C motif chemokine ligand 3 Rattus norvegicus 53-57 8428969-1 1993 The stoichiometric reductive debromination of BrCCl3 to a trichloromethyl radical by myoglobin caused the prosthetic heme to become covalently cross-linked to the protein moiety and transformed myoglobin from an oxygen storage protein to an oxidase. trichloromethyl free radical 58-81 myoglobin Homo sapiens 85-94 8428969-1 1993 The stoichiometric reductive debromination of BrCCl3 to a trichloromethyl radical by myoglobin caused the prosthetic heme to become covalently cross-linked to the protein moiety and transformed myoglobin from an oxygen storage protein to an oxidase. trichloromethyl free radical 58-81 myoglobin Homo sapiens 194-203 1581896-15 1992 Microsomal reductive metabolism of PEN led to formation of a metabolite tentatively identified as a molecule formed by dimerization of the radical species produced by cleavage of chlorine from the trichloromethyl moiety of penclomedine. trichloromethyl free radical 197-212 proprotein convertase subtilisin/kexin type 1 inhibitor Mus musculus 35-38 1930739-1 1991 Carbon tetrachloride (CCl4) undergoes hepatic reductive metabolism to trichloromethyl (.CCl3) and peroxytrichloromethyl (CCl3OO.) trichloromethyl free radical 70-85 C-C motif chemokine ligand 4 Homo sapiens 22-26 1310168-3 1992 When hepatic microsomes from ethanol-treated or control rats were incubated with CCl4 and the spin trapping agent alpha-phenyl-N-tert-butylnitrone (PBN), the ESR signal of the trichloromethyl radical adduct of PBN was of similar intensity in both groups. trichloromethyl free radical 176-199 C-C motif chemokine ligand 4 Rattus norvegicus 81-85 1310168-5 1992 When PBN and CCl4 were administered to rats, liver extracts contained ESR signals resulting primarily from the trichloromethyl radical adduct of PBN, and the signals were of similar intensity in both experimental groups. trichloromethyl free radical 111-134 C-C motif chemokine ligand 4 Rattus norvegicus 13-17 1310168-9 1992 The data in this report fail to support the hypothesis that a single dose of ethanol stimulates the hepatic metabolism of CCl4 to the trichloromethyl radical. trichloromethyl free radical 134-157 C-C motif chemokine ligand 4 Rattus norvegicus 122-126 1310168-10 1992 Alternatively, ethanol may potentiate CCl4 toxicity by affecting some critical metabolic step subsequent to trichloromethyl radical formation. trichloromethyl free radical 108-131 C-C motif chemokine ligand 4 Rattus norvegicus 38-42 1930739-1 1991 Carbon tetrachloride (CCl4) undergoes hepatic reductive metabolism to trichloromethyl (.CCl3) and peroxytrichloromethyl (CCl3OO.) trichloromethyl free radical 70-85 C-C motif chemokine ligand 3 Homo sapiens 88-92 1645621-8 1991 Evidence to support this hypothesis was developed by adding bovine serum albumin (BSA) to an aqueous solution of the trichloromethyl radical adduct of PBN. trichloromethyl free radical 117-140 albumin Rattus norvegicus 67-80 2869522-2 1985 These hepatotoxic effects of CCl4 are dependent upon its metabolic activation in the liver endoplasmic reticulum to reactive intermediates, including the trichloromethyl free radical. trichloromethyl free radical 154-182 C-C motif chemokine ligand 4 Rattus norvegicus 29-33 2156156-1 1990 Carbon tetrachloride and bromotrichloromethane are both metabolized by cytochrome P-450 in the presence of phenyl-N-t-butyl nitrone PBN) to the PBN/trichloromethyl (PBN/.CCl3) and the PBN carbon dioxide anion (PBN/.CO2-) radical adducts in the liver. trichloromethyl free radical 148-163 C-C motif chemokine ligand 3 Homo sapiens 170-174 34913455-2 2022 Here we investigate the photodissociation dynamics of the trichloromethyl radical, CCl3 after excitation in the ultraviolet. trichloromethyl free radical 58-81 C-C motif chemokine ligand 3 Homo sapiens 83-87 3245227-5 1988 Analysis of the hepatic lipid extracts revealed a signal due to the trichloromethyl radical (CCl3) adduct of PBN. trichloromethyl free radical 68-91 C-C motif chemokine ligand 3 Rattus norvegicus 93-97 2825631-3 1987 Isolated rat liver mitochondria incubated under hypoxic conditions with succinate and ADP were found able to activate CCl4 to a free-radical species identified as trichloromethyl free radical (CCl3) by e.s.r. trichloromethyl free radical 163-191 C-C motif chemokine ligand 4 Rattus norvegicus 118-122 2825631-3 1987 Isolated rat liver mitochondria incubated under hypoxic conditions with succinate and ADP were found able to activate CCl4 to a free-radical species identified as trichloromethyl free radical (CCl3) by e.s.r. trichloromethyl free radical 163-191 C-C motif chemokine ligand 3 Rattus norvegicus 193-197 3526996-6 1986 Metabolism of CCl4 to the trichloromethyl radical by the hepatic mixed-function oxidase system results in the initiation of lipid peroxidation, protein-lipid cross linkages, and trichloromethyl adducts with DNA, protein, and lipid. trichloromethyl free radical 26-49 C-C motif chemokine ligand 4 Homo sapiens 14-18 34917083-6 2021 Moreover, Ccl3 contributed to the high signature score of C-C motif chemokine receptor 1 (Ccr1)-positive macrophages. trichloromethyl free radical 10-14 chemokine (C-C motif) receptor 1 Mus musculus 58-88 34917083-6 2021 Moreover, Ccl3 contributed to the high signature score of C-C motif chemokine receptor 1 (Ccr1)-positive macrophages. trichloromethyl free radical 10-14 chemokine (C-C motif) receptor 1 Mus musculus 90-94 24480-0 1978 Spin-trapping of the trichloromethyl radical produced during enzymic NADPH oxidation in the presence of carbon tetrachloride or bromotrichloromethane. trichloromethyl free radical 21-44 spindlin 1 Rattus norvegicus 0-4 7082330-6 1982 This polypeptide, which was shown to disappear from liver microsomes following treatment of rats with CCl4 was demonstrated in the accompanying report to be the form of cytochrome P-450 specifically required for production of the highly reactive trichloromethyl radical in a reconstituted monooxygenase system. trichloromethyl free radical 247-270 C-C motif chemokine ligand 4 Rattus norvegicus 103-107 7082330-6 1982 This polypeptide, which was shown to disappear from liver microsomes following treatment of rats with CCl4 was demonstrated in the accompanying report to be the form of cytochrome P-450 specifically required for production of the highly reactive trichloromethyl radical in a reconstituted monooxygenase system. trichloromethyl free radical 247-270 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 170-186 7082331-0 1982 Specificity of a phenobarbital-induced cytochrome P-450 for metabolism of carbon tetrachloride to the trichloromethyl radical. trichloromethyl free radical 102-125 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 39-55 7082331-2 1982 Data are also presented which show that this form of cytochrome P-450 was capable of generating the trichloromethyl radical from CCl4 in a reconstituted system containing the purified cytochrome, NADPH-cytochrome P-450 reductase, NADPH, CCl4, and the spin-trapping agent, phenyl-t-butyl nitrone. trichloromethyl free radical 100-123 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 53-69 7082331-2 1982 Data are also presented which show that this form of cytochrome P-450 was capable of generating the trichloromethyl radical from CCl4 in a reconstituted system containing the purified cytochrome, NADPH-cytochrome P-450 reductase, NADPH, CCl4, and the spin-trapping agent, phenyl-t-butyl nitrone. trichloromethyl free radical 100-123 C-C motif chemokine ligand 4 Rattus norvegicus 129-133 7082331-2 1982 Data are also presented which show that this form of cytochrome P-450 was capable of generating the trichloromethyl radical from CCl4 in a reconstituted system containing the purified cytochrome, NADPH-cytochrome P-450 reductase, NADPH, CCl4, and the spin-trapping agent, phenyl-t-butyl nitrone. trichloromethyl free radical 100-123 cytochrome p450 oxidoreductase Rattus norvegicus 196-228 7082331-2 1982 Data are also presented which show that this form of cytochrome P-450 was capable of generating the trichloromethyl radical from CCl4 in a reconstituted system containing the purified cytochrome, NADPH-cytochrome P-450 reductase, NADPH, CCl4, and the spin-trapping agent, phenyl-t-butyl nitrone. trichloromethyl free radical 100-123 C-C motif chemokine ligand 4 Rattus norvegicus 237-241 6700577-7 1984 The first step of the reaction is the cytochrome P-450-dependent reductive dechlorination of CCl4 to trichloromethyl radical (CCl3.). trichloromethyl free radical 101-124 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 38-54 6700577-7 1984 The first step of the reaction is the cytochrome P-450-dependent reductive dechlorination of CCl4 to trichloromethyl radical (CCl3.). trichloromethyl free radical 101-124 C-C motif chemokine ligand 4 Rattus norvegicus 93-97 6700577-7 1984 The first step of the reaction is the cytochrome P-450-dependent reductive dechlorination of CCl4 to trichloromethyl radical (CCl3.). trichloromethyl free radical 101-124 C-C motif chemokine ligand 3 Rattus norvegicus 126-130 6288023-7 1982 The results obtained with the spin trap N-benzylidene-2-methylpropylamine N-oxide ("phenyl t-butyl nitrone") (PBN) and [13C]carbon tetrachloride provide unequivocal evidence for the formation and trapping of the trichloromethyl free radical in these systems. trichloromethyl free radical 212-240 spindlin 1 Rattus norvegicus 30-34 7089997-4 1982 The enhanced susceptibility to CC1(4) induced by fasting seemed to be due to the accelerated bioactivation of CC1(4) to the toxic trichloromethyl free radical. trichloromethyl free radical 130-158 Cardiac cell morphology QTL 1 Rattus norvegicus 31-34 7089997-4 1982 The enhanced susceptibility to CC1(4) induced by fasting seemed to be due to the accelerated bioactivation of CC1(4) to the toxic trichloromethyl free radical. trichloromethyl free radical 130-158 Cardiac cell morphology QTL 1 Rattus norvegicus 110-113 7291720-1 1981 Trichloromethyl free radicals from CCl4, chemically produced by benzoyl peroxide catalysis, interact with the four DNA bases. trichloromethyl free radical 0-29 C-C motif chemokine ligand 4 Homo sapiens 35-39 7394319-1 1980 Trichloromethyl free radicals produced from CCl4 in a benzoyl-peroxide catalyzed chemical reaction are able to interact with several aminoacid esters. trichloromethyl free radical 0-29 C-C motif chemokine ligand 4 Homo sapiens 44-48 1133769-10 1975 A new hypothesis is put forward which states that the activation of CCl4 to trichloromethyl free radicals takes place at two sites on the reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 electron-transport chain of liver microsomes. trichloromethyl free radical 76-105 C-C motif chemokine ligand 4 Rattus norvegicus 68-72 1133769-10 1975 A new hypothesis is put forward which states that the activation of CCl4 to trichloromethyl free radicals takes place at two sites on the reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 electron-transport chain of liver microsomes. trichloromethyl free radical 76-105 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 190-206 32194558-13 2020 Lastly, selective blockage of CCR1/CCR5 (Met-RANTES therapy) in chronically infected ccl3+/+ mice reversed pivotal electrical abnormalities (bradycardia, prolonged PR, and QTc interval), in correlation with reduced TNF and, mainly, CCL3 levels in the heart tissue. trichloromethyl free radical 85-89 chemokine (C-C motif) receptor 1 Mus musculus 30-34 32194558-13 2020 Lastly, selective blockage of CCR1/CCR5 (Met-RANTES therapy) in chronically infected ccl3+/+ mice reversed pivotal electrical abnormalities (bradycardia, prolonged PR, and QTc interval), in correlation with reduced TNF and, mainly, CCL3 levels in the heart tissue. trichloromethyl free radical 85-89 chemokine (C-C motif) receptor 5 Mus musculus 35-39 24480-4 1978 A computer-simulated ESR spectrum for the trichloromethyl adduct of phenyl-t-butyl nitrone can reproduce the essential features of the spectrum of the spin-trapped radical produced enzymically from CCl4. trichloromethyl free radical 42-57 spindlin 1 Rattus norvegicus 151-155 24480-4 1978 A computer-simulated ESR spectrum for the trichloromethyl adduct of phenyl-t-butyl nitrone can reproduce the essential features of the spectrum of the spin-trapped radical produced enzymically from CCl4. trichloromethyl free radical 42-57 C-C motif chemokine ligand 4 Rattus norvegicus 198-202 24480-5 1978 A mechanism is proposed for the formation of the trichloromethyl radical from CCl4 or BrCCl3. trichloromethyl free radical 49-72 C-C motif chemokine ligand 4 Rattus norvegicus 78-82