PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27884766-7	2017	In vitro, 10 muM GSK2256294 increased 11,12-EET-mediated vasodilation compared with vehicle (90% +- 4.2% vs 72.6% +- 6.2% maximal dilatation) and shifted the bradykinin half-maximal effective concentration (EC50) (-8.33 +- 0.172 logM vs -8.10 +- 0.118 logM; P = .001 for EC50).	11,12-epoxy-5,8,14-eicosatrienoic acid	38-47	kininogen 1	Homo sapiens	158-168
33990688-9	2021	Moreover, 11,12-EET and TPPU decreased TGF-beta1-induced p-Smad2/3 and extracellular-signal-regulated kinase (ERK) expression in primary fibroblasts from patients with IPF and fibronectin expression in Beas-2B cells.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	transforming growth factor beta 1	Homo sapiens	39-48
34142887-9	2021	In vitro, 11,12-EET treatment attenuated nicotine-induced MMP2 upregulation via SIRT1-mediated YAP deacetylation.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	matrix metallopeptidase 2	Mus musculus	58-62
34142887-9	2021	In vitro, 11,12-EET treatment attenuated nicotine-induced MMP2 upregulation via SIRT1-mediated YAP deacetylation.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	sirtuin 1	Mus musculus	80-85
34142887-9	2021	In vitro, 11,12-EET treatment attenuated nicotine-induced MMP2 upregulation via SIRT1-mediated YAP deacetylation.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	yes-associated protein 1	Mus musculus	95-98
33990688-7	2021	11,12-EET significantly decreased transforming growth factor (TGF)-beta1-induced expression of alpha-smooth muscle actin (SMA) and collagen type-I in MRC-5 cells and primary fibroblasts from IPF patients.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	transforming growth factor beta 1	Homo sapiens	34-72
2820243-10	1987	Both 5,6-EET and 11,12-EET (10(-5) M) prevented the increase in intracellular cAMP content observed in control tissues after vasopressin stimulation.	11,12-epoxy-5,8,14-eicosatrienoic acid	17-26	arginine vasopressin	Homo sapiens	125-136
33958662-5	2021	Exogenous 11,12-EET and 19,20-EDP significantly decreased PA- and IL-1beta-induced MC expression of IL-1beta and IL-6.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	interleukin 1 alpha	Homo sapiens	66-74
33958662-5	2021	Exogenous 11,12-EET and 19,20-EDP significantly decreased PA- and IL-1beta-induced MC expression of IL-1beta and IL-6.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	interleukin 1 alpha	Homo sapiens	100-108
33958662-5	2021	Exogenous 11,12-EET and 19,20-EDP significantly decreased PA- and IL-1beta-induced MC expression of IL-1beta and IL-6.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	interleukin 6	Homo sapiens	113-117
33958662-7	2021	Interestingly, 11,12-EET and 19,20-EDP significantly increased TNFalpha in IL-1beta-treated MC.	11,12-epoxy-5,8,14-eicosatrienoic acid	15-24	tumor necrosis factor	Homo sapiens	63-71
33958662-7	2021	Interestingly, 11,12-EET and 19,20-EDP significantly increased TNFalpha in IL-1beta-treated MC.	11,12-epoxy-5,8,14-eicosatrienoic acid	15-24	interleukin 1 alpha	Homo sapiens	75-83
33958662-9	2021	11,12-EET and 19,20-EDP were also found to decrease PA- and IL-1beta-induced NFkappaB-dependent transcriptional activity.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	interleukin 1 alpha	Homo sapiens	60-68
33990688-9	2021	Moreover, 11,12-EET and TPPU decreased TGF-beta1-induced p-Smad2/3 and extracellular-signal-regulated kinase (ERK) expression in primary fibroblasts from patients with IPF and fibronectin expression in Beas-2B cells.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	SMAD family member 2	Homo sapiens	59-66
33990688-9	2021	Moreover, 11,12-EET and TPPU decreased TGF-beta1-induced p-Smad2/3 and extracellular-signal-regulated kinase (ERK) expression in primary fibroblasts from patients with IPF and fibronectin expression in Beas-2B cells.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	mitogen-activated protein kinase 1	Homo sapiens	71-108
33990688-9	2021	Moreover, 11,12-EET and TPPU decreased TGF-beta1-induced p-Smad2/3 and extracellular-signal-regulated kinase (ERK) expression in primary fibroblasts from patients with IPF and fibronectin expression in Beas-2B cells.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	mitogen-activated protein kinase 1	Homo sapiens	110-113
33990688-9	2021	Moreover, 11,12-EET and TPPU decreased TGF-beta1-induced p-Smad2/3 and extracellular-signal-regulated kinase (ERK) expression in primary fibroblasts from patients with IPF and fibronectin expression in Beas-2B cells.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	fibronectin 1	Homo sapiens	176-187
33990688-11	2021	11,12-EET or sEH inhibitors could inhibit pulmonary fibrosis by regulating TGF-beta1-induced profibrotic signaling, suggesting that 11,12-EET and the regulation of EETs could serve as potential therapeutic targets for IPF treatment.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	transforming growth factor, beta 1	Mus musculus	75-84
33990688-11	2021	11,12-EET or sEH inhibitors could inhibit pulmonary fibrosis by regulating TGF-beta1-induced profibrotic signaling, suggesting that 11,12-EET and the regulation of EETs could serve as potential therapeutic targets for IPF treatment.	11,12-epoxy-5,8,14-eicosatrienoic acid	132-141	epoxide hydrolase 2, cytoplasmic	Mus musculus	13-16
33990688-11	2021	11,12-EET or sEH inhibitors could inhibit pulmonary fibrosis by regulating TGF-beta1-induced profibrotic signaling, suggesting that 11,12-EET and the regulation of EETs could serve as potential therapeutic targets for IPF treatment.	11,12-epoxy-5,8,14-eicosatrienoic acid	132-141	transforming growth factor, beta 1	Mus musculus	75-84
32452554-8	2020	Importantly, four EETs (5,6-EET, 8,9-EET, 11,12-EET, and 14,15-EET) inhibited the activation of NLRP3 inflammasome induced by LPS + ATP or LPS + nigericin in macrophages in various degree.	11,12-epoxy-5,8,14-eicosatrienoic acid	42-51	NLR family, pyrin domain containing 3	Mus musculus	96-101
33068391-6	2021	In our analysis, we profiled 48 Lipid Mediators (LMs) derived from various essential polyunsaturated fatty acids to determine potential targets regulated by SREBF1, and found that the levels of 11,12 epoxyeicosatrienoic acid (11,12-EET) were negatively associated with the number of SREBF1 alleles (p=0.006 for a linear model).	11,12-epoxy-5,8,14-eicosatrienoic acid	194-224	sterol regulatory element binding transcription factor 1	Danio rerio	157-163
33068391-6	2021	In our analysis, we profiled 48 Lipid Mediators (LMs) derived from various essential polyunsaturated fatty acids to determine potential targets regulated by SREBF1, and found that the levels of 11,12 epoxyeicosatrienoic acid (11,12-EET) were negatively associated with the number of SREBF1 alleles (p=0.006 for a linear model).	11,12-epoxy-5,8,14-eicosatrienoic acid	194-224	sterol regulatory element binding transcription factor 1	Danio rerio	283-289
33068391-6	2021	In our analysis, we profiled 48 Lipid Mediators (LMs) derived from various essential polyunsaturated fatty acids to determine potential targets regulated by SREBF1, and found that the levels of 11,12 epoxyeicosatrienoic acid (11,12-EET) were negatively associated with the number of SREBF1 alleles (p=0.006 for a linear model).	11,12-epoxy-5,8,14-eicosatrienoic acid	226-235	sterol regulatory element binding transcription factor 1	Danio rerio	283-289
33330047-12	2020	CYP2J2 knockdown restrained the release of 11,12-EET and significantly enhanced the anti-tumor effect of JWH133 on glioma.	11,12-epoxy-5,8,14-eicosatrienoic acid	43-52	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	0-6
32415198-8	2020	Further, serum levels of these specific HETEs, except for 11,12-EET, were positively correlated to the levels of some inflammatory and cardiac biomarker such as tumor necrosis factor-alpha and N-terminal pro B-type natriuretic peptide.	11,12-epoxy-5,8,14-eicosatrienoic acid	58-67	tumor necrosis factor	Homo sapiens	161-188
31954161-6	2020	Moreover, exogenous 11,12-EET addition obviously promoted I/R-induced autophagic flux and suppressed I/R-induced apoptosis through SIRT1-FoxO3a signaling activation.	11,12-epoxy-5,8,14-eicosatrienoic acid	20-29	sirtuin 1	Rattus norvegicus	131-136
31954161-6	2020	Moreover, exogenous 11,12-EET addition obviously promoted I/R-induced autophagic flux and suppressed I/R-induced apoptosis through SIRT1-FoxO3a signaling activation.	11,12-epoxy-5,8,14-eicosatrienoic acid	20-29	forkhead box O3	Rattus norvegicus	137-143
30219518-10	2018	Additionally, in vitro study demonstrated that 11, 12-epoxyeicosatrienoic acid (11, 12-EET) induced more robust tube formation and markedly increased VEGF-A and bFGF expression in hypoxia and normoxia.	11,12-epoxy-5,8,14-eicosatrienoic acid	47-78	vascular endothelial growth factor A	Rattus norvegicus	150-156
31669255-8	2020	In summary, our findings extend current knowledge of 11,12-EET signaling events and emphasize the importance of the AKT/mTOR/p70S6K pathway in hepatic 11,12-EET signaling.	11,12-epoxy-5,8,14-eicosatrienoic acid	151-160	AKT serine/threonine kinase 1	Homo sapiens	116-119
31669255-8	2020	In summary, our findings extend current knowledge of 11,12-EET signaling events and emphasize the importance of the AKT/mTOR/p70S6K pathway in hepatic 11,12-EET signaling.	11,12-epoxy-5,8,14-eicosatrienoic acid	151-160	mechanistic target of rapamycin kinase	Homo sapiens	120-124
31669255-8	2020	In summary, our findings extend current knowledge of 11,12-EET signaling events and emphasize the importance of the AKT/mTOR/p70S6K pathway in hepatic 11,12-EET signaling.	11,12-epoxy-5,8,14-eicosatrienoic acid	151-160	ribosomal protein S6 kinase B1	Homo sapiens	125-131
30219518-10	2018	Additionally, in vitro study demonstrated that 11, 12-epoxyeicosatrienoic acid (11, 12-EET) induced more robust tube formation and markedly increased VEGF-A and bFGF expression in hypoxia and normoxia.	11,12-epoxy-5,8,14-eicosatrienoic acid	47-78	fibroblast growth factor 2	Rattus norvegicus	161-165
30219518-10	2018	Additionally, in vitro study demonstrated that 11, 12-epoxyeicosatrienoic acid (11, 12-EET) induced more robust tube formation and markedly increased VEGF-A and bFGF expression in hypoxia and normoxia.	11,12-epoxy-5,8,14-eicosatrienoic acid	80-90	vascular endothelial growth factor A	Rattus norvegicus	150-156
30219518-10	2018	Additionally, in vitro study demonstrated that 11, 12-epoxyeicosatrienoic acid (11, 12-EET) induced more robust tube formation and markedly increased VEGF-A and bFGF expression in hypoxia and normoxia.	11,12-epoxy-5,8,14-eicosatrienoic acid	80-90	fibroblast growth factor 2	Rattus norvegicus	161-165
30219518-11	2018	Finally, western blot analyses uncovered that CYP2J2 and 11, 12-EET promoted angiogenesis via the Jagged1/Notch1 signaling pathway.	11,12-epoxy-5,8,14-eicosatrienoic acid	57-67	jagged canonical Notch ligand 1	Rattus norvegicus	98-105
30219518-11	2018	Finally, western blot analyses uncovered that CYP2J2 and 11, 12-EET promoted angiogenesis via the Jagged1/Notch1 signaling pathway.	11,12-epoxy-5,8,14-eicosatrienoic acid	57-67	notch receptor 1	Rattus norvegicus	106-112
29066182-9	2017	Inhibition of ER stress suppressed sEH upregulation, resulting in an increase of 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	81-90	epoxide hydrolase 2	Homo sapiens	35-38
29552858-4	2018	The effects of OP-D and 11,12-EET on phosphorylation of JNK/c-Jun induced by Ang II were measured by Western blot and RT-PCR with the help of JNK specific inhibitor SP600125 and CYP450 isozymes selective inhibitor 6-(2-propargyloxyphenyl) hexanoic acid (PPOH).	11,12-epoxy-5,8,14-eicosatrienoic acid	24-33	mitogen-activated protein kinase 8	Homo sapiens	56-59
29552858-4	2018	The effects of OP-D and 11,12-EET on phosphorylation of JNK/c-Jun induced by Ang II were measured by Western blot and RT-PCR with the help of JNK specific inhibitor SP600125 and CYP450 isozymes selective inhibitor 6-(2-propargyloxyphenyl) hexanoic acid (PPOH).	11,12-epoxy-5,8,14-eicosatrienoic acid	24-33	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	60-65
29552858-4	2018	The effects of OP-D and 11,12-EET on phosphorylation of JNK/c-Jun induced by Ang II were measured by Western blot and RT-PCR with the help of JNK specific inhibitor SP600125 and CYP450 isozymes selective inhibitor 6-(2-propargyloxyphenyl) hexanoic acid (PPOH).	11,12-epoxy-5,8,14-eicosatrienoic acid	24-33	angiogenin	Homo sapiens	77-80
29777058-3	2018	14,15-EET, 11,12-EET, arachidonic acid, and the GPR40 agonist GW9508 increase intracellular calcium concentrations in human GPR40-overexpressing HEK293 cells (EC50 = 0.58 +- 0.08 mum, 0.91 +- 0.08 mum, 3.9 +- 0.06 mum, and 19 +- 0.37 nm, respectively).	11,12-epoxy-5,8,14-eicosatrienoic acid	11-20	free fatty acid receptor 1	Homo sapiens	124-129
29777058-11	2018	Moreover, siRNA-mediated GPR40 silencing decreased 11,12-EET-induced ERK phosphorylation.	11,12-epoxy-5,8,14-eicosatrienoic acid	51-60	free fatty acid receptor 1	Homo sapiens	25-30
29777058-13	2018	We conclude that epoxidation of arachidonic acid to EETs enhances GPR40 agonist activity and that 11,12-EET stimulation of GPR40 increases Cx43 and COX-2 expression in ECs via ERK phosphorylation.	11,12-epoxy-5,8,14-eicosatrienoic acid	98-107	free fatty acid receptor 1	Homo sapiens	123-128
29777058-13	2018	We conclude that epoxidation of arachidonic acid to EETs enhances GPR40 agonist activity and that 11,12-EET stimulation of GPR40 increases Cx43 and COX-2 expression in ECs via ERK phosphorylation.	11,12-epoxy-5,8,14-eicosatrienoic acid	98-107	gap junction protein alpha 1	Homo sapiens	139-143
29777058-13	2018	We conclude that epoxidation of arachidonic acid to EETs enhances GPR40 agonist activity and that 11,12-EET stimulation of GPR40 increases Cx43 and COX-2 expression in ECs via ERK phosphorylation.	11,12-epoxy-5,8,14-eicosatrienoic acid	98-107	prostaglandin-endoperoxide synthase 2	Homo sapiens	148-153
29345370-10	2018	Treatment of eosinophils with t-TUCB significantly inhibited eosinophil migration, an effect that was mirrored by treatment with 11,12-EET, by inhibiting intracellular signaling events such as ERK (1/2) activation and eotaxin-1-induced calcium flux.	11,12-epoxy-5,8,14-eicosatrienoic acid	129-138	mitogen-activated protein kinase 3	Mus musculus	193-201
29427791-9	2018	Similarly, exogenous 11,12-EET addition significantly restored ethanol-induced neonatal rat cardiomyocyte autophagic flux impairment and inhibited apoptosis, both of which were mediated by AMPK/mTOR signaling pathway in vitro.	11,12-epoxy-5,8,14-eicosatrienoic acid	21-30	mechanistic target of rapamycin kinase	Rattus norvegicus	194-198
27753791-8	2017	In addition, in vitro experiments revealed that both TPPU and EETs (11,12-EET and 14,15-EET) suppressed the expression of IL-1beta and TNF-alpha, and LDH release in RAW264.7 cells.	11,12-epoxy-5,8,14-eicosatrienoic acid	68-77	interleukin 1 beta	Mus musculus	122-130
28587983-6	2017	Furthermore, treatment with exogenous 11,12-EET attenuated endothelial inflammation induced by Ang II as evidenced by inhibited NF-kappaB nuclear translocation, increased IkappaBalpha expression and decreased inflammation factor level.	11,12-epoxy-5,8,14-eicosatrienoic acid	38-47	NFKB inhibitor alpha	Homo sapiens	171-183
28554983-7	2017	In in vitro studies, cardiac fibroblast activation, proliferation, migration, and collagen production induced by Ang II were associated with activation of the Galpha12/13/RhoA/ROCK pathway, which was inhibited by exogenous 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	223-232	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	113-119
28554983-7	2017	In in vitro studies, cardiac fibroblast activation, proliferation, migration, and collagen production induced by Ang II were associated with activation of the Galpha12/13/RhoA/ROCK pathway, which was inhibited by exogenous 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	223-232	guanine nucleotide binding protein, alpha 12	Mus musculus	159-167
28554983-7	2017	In in vitro studies, cardiac fibroblast activation, proliferation, migration, and collagen production induced by Ang II were associated with activation of the Galpha12/13/RhoA/ROCK pathway, which was inhibited by exogenous 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	223-232	ras homolog family member A	Mus musculus	171-175
28554983-8	2017	Moreover, silencing of Galpha12/13 or RhoA exerted similar effects as 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	70-79	guanine nucleotide binding protein, alpha 12	Mus musculus	23-34
28554983-9	2017	Furthermore, inhibitory effects of 11,12-EET on Galpha12/13 were blocked by NO/cGMP pathway inhibitors.	11,12-epoxy-5,8,14-eicosatrienoic acid	35-44	guanine nucleotide binding protein, alpha 12	Mus musculus	48-56
29050342-0	2017	Role of the CYP3A4-mediated 11,12-epoxyeicosatrienoic acid pathway in the development of tamoxifen-resistant breast cancer.	11,12-epoxy-5,8,14-eicosatrienoic acid	28-58	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	12-18
29050342-3	2017	Here, we found that CYP3A4 expression and its epoxy-product, 11,12-epoxyeicosatrienoic acid (11,12-EET) was enhanced in tamoxifen (TAM)-resistant MCF-7 (TAMR-MCF-7) breast cancer cells compared to control MCF-7 cells.	11,12-epoxy-5,8,14-eicosatrienoic acid	61-91	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	20-26
29050342-3	2017	Here, we found that CYP3A4 expression and its epoxy-product, 11,12-epoxyeicosatrienoic acid (11,12-EET) was enhanced in tamoxifen (TAM)-resistant MCF-7 (TAMR-MCF-7) breast cancer cells compared to control MCF-7 cells.	11,12-epoxy-5,8,14-eicosatrienoic acid	93-102	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	20-26
27753791-8	2017	In addition, in vitro experiments revealed that both TPPU and EETs (11,12-EET and 14,15-EET) suppressed the expression of IL-1beta and TNF-alpha, and LDH release in RAW264.7 cells.	11,12-epoxy-5,8,14-eicosatrienoic acid	68-77	tumor necrosis factor	Mus musculus	135-144
27416746-7	2016	The CYP2J2 metabolites, 11,12-EET, activated AMPKalpha2 to induce nuclear translocation of p-Akt1 selectively, which increased the production of ANP and therefore inhibited the development of cardiac hypertrophy.	11,12-epoxy-5,8,14-eicosatrienoic acid	24-33	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	45-55
28384353-4	2017	A novel epoxide hydrolase, EPHX3, was recently identified by sequence homology and also exhibits epoxide hydrolase activity in vitro with a substrate preference for 9,10-epoxyoctadecamonoenoic acid (EpOME) and 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	210-219	epoxide hydrolase 3	Mus musculus	27-32
27966642-4	2016	Exogenous addition of 11,12-EET or 19,20-EDP when combined with 12-(3-adamantane-1-yl-ureido)-dodecanoic acid (AUDA), an inhibitor of epoxide hydrolysis, inhibited VCAM-1 and ICAM-1 expression and protein levels; conversely the diol product of 19,20-EDP hydrolysis, 19,20-DHDP, induced VCAM1 and ICAM1 expression.	11,12-epoxy-5,8,14-eicosatrienoic acid	22-31	vascular cell adhesion molecule 1	Homo sapiens	164-170
27966642-4	2016	Exogenous addition of 11,12-EET or 19,20-EDP when combined with 12-(3-adamantane-1-yl-ureido)-dodecanoic acid (AUDA), an inhibitor of epoxide hydrolysis, inhibited VCAM-1 and ICAM-1 expression and protein levels; conversely the diol product of 19,20-EDP hydrolysis, 19,20-DHDP, induced VCAM1 and ICAM1 expression.	11,12-epoxy-5,8,14-eicosatrienoic acid	22-31	intercellular adhesion molecule 1	Homo sapiens	175-181
27966642-4	2016	Exogenous addition of 11,12-EET or 19,20-EDP when combined with 12-(3-adamantane-1-yl-ureido)-dodecanoic acid (AUDA), an inhibitor of epoxide hydrolysis, inhibited VCAM-1 and ICAM-1 expression and protein levels; conversely the diol product of 19,20-EDP hydrolysis, 19,20-DHDP, induced VCAM1 and ICAM1 expression.	11,12-epoxy-5,8,14-eicosatrienoic acid	22-31	vascular cell adhesion molecule 1	Homo sapiens	286-291
27966642-4	2016	Exogenous addition of 11,12-EET or 19,20-EDP when combined with 12-(3-adamantane-1-yl-ureido)-dodecanoic acid (AUDA), an inhibitor of epoxide hydrolysis, inhibited VCAM-1 and ICAM-1 expression and protein levels; conversely the diol product of 19,20-EDP hydrolysis, 19,20-DHDP, induced VCAM1 and ICAM1 expression.	11,12-epoxy-5,8,14-eicosatrienoic acid	22-31	intercellular adhesion molecule 1	Homo sapiens	296-301
28332266-5	2017	The vasodilator response induced by 11, 12-EET was significantly decreased in tissues obtained from diabetic animals, but this was significantly corrected through inhibition of sEH.	11,12-epoxy-5,8,14-eicosatrienoic acid	36-46	epoxide hydrolase 2	Rattus norvegicus	177-180
27681558-4	2016	Here, we show that chronic treatment of AVP-deficient Brattleboro rats with the AVP V2 receptor analog desmopressin (dDAVP; 5 ng/h, 3 days) significantly lowered renal EET levels (-56 +- 3% for 5,6-EET, -50 +- 3.4% for 11,12-EET, and -60 +- 3.7% for 14,15-EET).	11,12-epoxy-5,8,14-eicosatrienoic acid	219-228	arginine vasopressin	Rattus norvegicus	40-43
27681558-4	2016	Here, we show that chronic treatment of AVP-deficient Brattleboro rats with the AVP V2 receptor analog desmopressin (dDAVP; 5 ng/h, 3 days) significantly lowered renal EET levels (-56 +- 3% for 5,6-EET, -50 +- 3.4% for 11,12-EET, and -60 +- 3.7% for 14,15-EET).	11,12-epoxy-5,8,14-eicosatrienoic acid	219-228	arginine vasopressin	Rattus norvegicus	80-83
27416746-7	2016	The CYP2J2 metabolites, 11,12-EET, activated AMPKalpha2 to induce nuclear translocation of p-Akt1 selectively, which increased the production of ANP and therefore inhibited the development of cardiac hypertrophy.	11,12-epoxy-5,8,14-eicosatrienoic acid	24-33	thymoma viral proto-oncogene 1	Mus musculus	93-97
27079253-5	2016	APPROACH/RESULTS: When stabilized by an sEH inhibitor (seHi), 11,12-EET at a physiologically low dose (0.1nM) reduced cytokine-stimulated upregulation of adhesion molecules on human aorta endothelial cells (HAEC) and monocyte adhesion under shear flow through marked depolarization of the HAEC when combined with TNFalpha.	11,12-epoxy-5,8,14-eicosatrienoic acid	62-71	epoxide hydrolase 2	Homo sapiens	40-43
27079253-5	2016	APPROACH/RESULTS: When stabilized by an sEH inhibitor (seHi), 11,12-EET at a physiologically low dose (0.1nM) reduced cytokine-stimulated upregulation of adhesion molecules on human aorta endothelial cells (HAEC) and monocyte adhesion under shear flow through marked depolarization of the HAEC when combined with TNFalpha.	11,12-epoxy-5,8,14-eicosatrienoic acid	62-71	tumor necrosis factor	Homo sapiens	313-321
26489615-6	2015	Pretreatment with 11, 12-EET also significantly blocked TNF-alpha-induced ROS production.	11,12-epoxy-5,8,14-eicosatrienoic acid	18-28	tumor necrosis factor	Homo sapiens	56-65
26489615-8	2015	Furthermore, the ability of 11, 12-EET to protect cells against TNF-alpha-induced apoptosis via oxidative stress was abrogated by transient transfection with Nrf2-specific small interfering RNA (siRNA).	11,12-epoxy-5,8,14-eicosatrienoic acid	28-38	tumor necrosis factor	Homo sapiens	64-73
26489615-8	2015	Furthermore, the ability of 11, 12-EET to protect cells against TNF-alpha-induced apoptosis via oxidative stress was abrogated by transient transfection with Nrf2-specific small interfering RNA (siRNA).	11,12-epoxy-5,8,14-eicosatrienoic acid	28-38	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
25139746-11	2014	CONCLUSION: Our findings demonstrate a novel role of the NO-cGMP-PKG pathway in the inhibition of 11,12-EET-induced smooth muscle hyperpolarization and relaxation via PKG-mediated phosphorylation of TRPC1.	11,12-epoxy-5,8,14-eicosatrienoic acid	98-107	protein kinase cGMP-dependent 1	Homo sapiens	65-68
25815455-10	2015	TRPV4 may form a heteromeric channel with TRPC6 as the two channels coimmunoprecipitate from PASMC and as there is no additive effect of TRPC and TRPV4 inhibition on Ca influx in response to the agonist, 11,12-epoxyeicosatrienoic acid.	11,12-epoxy-5,8,14-eicosatrienoic acid	204-234	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	0-5
25511389-2	2015	Previous reports suggested that 11,12-epoxyeicosatrienoic acid (11,12-EET) is an important endothelial-derived hyperpolarizing factor (EDHF) in human LIMAs and that EETs act through large conductance Ca2+-activated K+ channels (KCa1.1) to induce smooth muscle cell hyperpolarization and relaxation in these tissues.	11,12-epoxy-5,8,14-eicosatrienoic acid	32-62	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	228-234
25511389-2	2015	Previous reports suggested that 11,12-epoxyeicosatrienoic acid (11,12-EET) is an important endothelial-derived hyperpolarizing factor (EDHF) in human LIMAs and that EETs act through large conductance Ca2+-activated K+ channels (KCa1.1) to induce smooth muscle cell hyperpolarization and relaxation in these tissues.	11,12-epoxy-5,8,14-eicosatrienoic acid	64-73	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	228-234
25511389-8	2015	The present study revealed that 11,12-EET targets the TRPV4-TRPC1-KCa1.1 complex to induce smooth muscle cell hyperpolarization and vascular relaxation in human LIMAs.	11,12-epoxy-5,8,14-eicosatrienoic acid	32-41	transient receptor potential cation channel subfamily V member 4	Homo sapiens	54-59
25511389-8	2015	The present study revealed that 11,12-EET targets the TRPV4-TRPC1-KCa1.1 complex to induce smooth muscle cell hyperpolarization and vascular relaxation in human LIMAs.	11,12-epoxy-5,8,14-eicosatrienoic acid	32-41	transient receptor potential cation channel subfamily C member 1	Homo sapiens	60-65
25511389-8	2015	The present study revealed that 11,12-EET targets the TRPV4-TRPC1-KCa1.1 complex to induce smooth muscle cell hyperpolarization and vascular relaxation in human LIMAs.	11,12-epoxy-5,8,14-eicosatrienoic acid	32-41	potassium calcium-activated channel subfamily M alpha 1	Homo sapiens	66-72
25618409-8	2015	In in vitro studies, 11,12-EET(1 mumol/L) treatment attenuated cardiomyocyte hypertrophy and remodelling-related protein (collagen I, TGF-beta1, TIMP1) expression by inhibiting the oxidative stress-mediated NF-kappaB pathway via PPAR-gamma activation.	11,12-epoxy-5,8,14-eicosatrienoic acid	21-30	transforming growth factor, beta 1	Mus musculus	134-143
25618409-8	2015	In in vitro studies, 11,12-EET(1 mumol/L) treatment attenuated cardiomyocyte hypertrophy and remodelling-related protein (collagen I, TGF-beta1, TIMP1) expression by inhibiting the oxidative stress-mediated NF-kappaB pathway via PPAR-gamma activation.	11,12-epoxy-5,8,14-eicosatrienoic acid	21-30	tissue inhibitor of metalloproteinase 1	Mus musculus	145-150
25618409-8	2015	In in vitro studies, 11,12-EET(1 mumol/L) treatment attenuated cardiomyocyte hypertrophy and remodelling-related protein (collagen I, TGF-beta1, TIMP1) expression by inhibiting the oxidative stress-mediated NF-kappaB pathway via PPAR-gamma activation.	11,12-epoxy-5,8,14-eicosatrienoic acid	21-30	peroxisome proliferator activated receptor gamma	Mus musculus	229-239
25618409-9	2015	Furthermore, conditioned media from neonatal cardiomyocytes treated with 11,12-EET inhibited activation of cardiac fibroblasts and TGF-beta1/smad pathway.	11,12-epoxy-5,8,14-eicosatrienoic acid	73-82	transforming growth factor, beta 1	Mus musculus	131-140
25139746-0	2014	Nitric oxide and protein kinase G act on TRPC1 to inhibit 11,12-EET-induced vascular relaxation.	11,12-epoxy-5,8,14-eicosatrienoic acid	58-67	protein kinase cGMP-dependent 1	Homo sapiens	17-33
25139746-0	2014	Nitric oxide and protein kinase G act on TRPC1 to inhibit 11,12-EET-induced vascular relaxation.	11,12-epoxy-5,8,14-eicosatrienoic acid	58-67	transient receptor potential cation channel subfamily C member 1	Homo sapiens	41-46
25139746-6	2014	The inhibitory actions of SNAP and 8-Br-cGMP on 11,12-EET-induced membrane hyperpolarization and vascular relaxation were reversed by hydroxocobalamin, an NO scavenger; ODQ, a guanylyl cyclase inhibitor; and KT5823, a protein kinase G (PKG) inhibitor.	11,12-epoxy-5,8,14-eicosatrienoic acid	48-57	protein kinase cGMP-dependent 1	Homo sapiens	218-234
25139746-6	2014	The inhibitory actions of SNAP and 8-Br-cGMP on 11,12-EET-induced membrane hyperpolarization and vascular relaxation were reversed by hydroxocobalamin, an NO scavenger; ODQ, a guanylyl cyclase inhibitor; and KT5823, a protein kinase G (PKG) inhibitor.	11,12-epoxy-5,8,14-eicosatrienoic acid	48-57	protein kinase cGMP-dependent 1	Homo sapiens	236-239
25467970-4	2015	Treatment with 11,12-EET or 14,15-EET attenuated the CSE-induced release of interleukin (IL)-8 by inhibiting the phosphorylation of p38 mitogen-activated protein kinases (MAPKs).	11,12-epoxy-5,8,14-eicosatrienoic acid	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	76-94
25870948-10	2015	In vitro data further confirmed the anti-inflammatory effect of CYP2J2 overexpression and 11,12-EET, an effect that may probably be mediated by PPARgamma activation.	11,12-epoxy-5,8,14-eicosatrienoic acid	90-99	peroxisome proliferator activated receptor gamma	Homo sapiens	144-153
25139746-11	2014	CONCLUSION: Our findings demonstrate a novel role of the NO-cGMP-PKG pathway in the inhibition of 11,12-EET-induced smooth muscle hyperpolarization and relaxation via PKG-mediated phosphorylation of TRPC1.	11,12-epoxy-5,8,14-eicosatrienoic acid	98-107	protein kinase cGMP-dependent 1	Homo sapiens	167-170
25139746-11	2014	CONCLUSION: Our findings demonstrate a novel role of the NO-cGMP-PKG pathway in the inhibition of 11,12-EET-induced smooth muscle hyperpolarization and relaxation via PKG-mediated phosphorylation of TRPC1.	11,12-epoxy-5,8,14-eicosatrienoic acid	98-107	transient receptor potential cation channel subfamily C member 1	Homo sapiens	199-204
24763066-4	2014	In primary cultures of human endothelial cells, (+-)-11,12-EET led to the rapid (30 seconds) translocation a TRPC6-V5 fusion protein, an effect reproduced by 11(R),12(S)-EET, but not by 11(S),12(R)-EET or (+-)-14,15-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	48-62	transient receptor potential cation channel subfamily C member 6	Homo sapiens	109-114
25017038-7	2014	Moreover, pretreatment with 11,12-EET significantly blocked TNF-alpha-induced ROS production.	11,12-epoxy-5,8,14-eicosatrienoic acid	28-37	tumor necrosis factor	Homo sapiens	60-69
24966089-10	2014	Also, patch-clamp experiments demonstrated that 11,12-EET, a major Cyp2c44 product, but not AA inhibited ENaC activity in the cortical CD of KO mice.	11,12-epoxy-5,8,14-eicosatrienoic acid	48-57	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	67-74
24966089-10	2014	Also, patch-clamp experiments demonstrated that 11,12-EET, a major Cyp2c44 product, but not AA inhibited ENaC activity in the cortical CD of KO mice.	11,12-epoxy-5,8,14-eicosatrienoic acid	48-57	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	105-109
24486707-8	2014	In addition, we confirmed that 11,12-EET suppresses phosphorylation of p38, degradation of IkappaBalpha, and activation of NF-kappaB (p65), whereas 14,15-EET can significantly suppress the phosphorylation of p38 and Erk1/2.	11,12-epoxy-5,8,14-eicosatrienoic acid	31-40	synaptotagmin 1	Rattus norvegicus	134-137
24486707-4	2014	We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular adhesion molecule-1 (ICAM-1), E-selectin, and monocyte chemoattractant protein-1 (MCP-1) in a concentration-dependent manner.	11,12-epoxy-5,8,14-eicosatrienoic acid	38-47	intercellular adhesion molecule 1	Rattus norvegicus	117-150
24058654-8	2013	Epoxygenase inhibition using a non-selective inhibitor SKF525A or a selective CYP2J2 inhibitor Compound 4, inhibited E. coli particle phagocytosis, which could be specifically reversed by 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	188-197	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	78-84
24486707-4	2014	We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular adhesion molecule-1 (ICAM-1), E-selectin, and monocyte chemoattractant protein-1 (MCP-1) in a concentration-dependent manner.	11,12-epoxy-5,8,14-eicosatrienoic acid	38-47	intercellular adhesion molecule 1	Rattus norvegicus	152-158
24486707-4	2014	We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular adhesion molecule-1 (ICAM-1), E-selectin, and monocyte chemoattractant protein-1 (MCP-1) in a concentration-dependent manner.	11,12-epoxy-5,8,14-eicosatrienoic acid	38-47	selectin E	Rattus norvegicus	161-171
24486707-4	2014	We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular adhesion molecule-1 (ICAM-1), E-selectin, and monocyte chemoattractant protein-1 (MCP-1) in a concentration-dependent manner.	11,12-epoxy-5,8,14-eicosatrienoic acid	38-47	C-C motif chemokine ligand 2	Rattus norvegicus	177-211
24486707-4	2014	We determined that pre-treatment with 11,12-EET or 14,15-EET attenuated the ox-LDL-induced expression and release of intercellular adhesion molecule-1 (ICAM-1), E-selectin, and monocyte chemoattractant protein-1 (MCP-1) in a concentration-dependent manner.	11,12-epoxy-5,8,14-eicosatrienoic acid	38-47	C-C motif chemokine ligand 2	Rattus norvegicus	213-218
24486707-5	2014	In addition, the ox-LDL-induced expression of CYP2J4 was upregulated by 11,12-EET and 14,15-EET (1muM).	11,12-epoxy-5,8,14-eicosatrienoic acid	72-81	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	46-52
24486707-8	2014	In addition, we confirmed that 11,12-EET suppresses phosphorylation of p38, degradation of IkappaBalpha, and activation of NF-kappaB (p65), whereas 14,15-EET can significantly suppress the phosphorylation of p38 and Erk1/2.	11,12-epoxy-5,8,14-eicosatrienoic acid	31-40	mitogen activated protein kinase 14	Rattus norvegicus	71-74
24486707-8	2014	In addition, we confirmed that 11,12-EET suppresses phosphorylation of p38, degradation of IkappaBalpha, and activation of NF-kappaB (p65), whereas 14,15-EET can significantly suppress the phosphorylation of p38 and Erk1/2.	11,12-epoxy-5,8,14-eicosatrienoic acid	31-40	NFKB inhibitor alpha	Rattus norvegicus	91-103
24058654-6	2013	The CYP2J2 arachidonic acid products 11,12-EET and 14,15-EET inhibited LPS induced TNFalpha release.	11,12-epoxy-5,8,14-eicosatrienoic acid	37-46	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	4-10
22184322-5	2012	In contrast, 11,12-epoxyeicosatrienoic acid, a Cyp2c44 metabolite, inhibited ENaC in the wt and Cyp2c44(-/-) mice.	11,12-epoxy-5,8,14-eicosatrienoic acid	13-43	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	47-54
23835530-7	2013	We also found that 11,12-EET and 14,15-EET significantly inhibited TGF-beta1-stimulated PASMC migration.	11,12-epoxy-5,8,14-eicosatrienoic acid	19-28	transforming growth factor beta 1	Homo sapiens	67-76
23302865-10	2013	Stimulation of serine/threonine protein phosphatase 2A (PP2A) contributes to 11,12-EET-induced activation of big conductance K channels and vasodilation in preglomerular arterioles.	11,12-epoxy-5,8,14-eicosatrienoic acid	77-86	protein phosphatase 2 phosphatase activator	Homo sapiens	56-60
23176298-13	2013	Both TUPS and 11,12-EET significantly decreased this isoprenaline-mediated induction of ANP, BNP and EPHX2.	11,12-epoxy-5,8,14-eicosatrienoic acid	14-23	natriuretic peptide B	Rattus norvegicus	93-96
23176298-13	2013	Both TUPS and 11,12-EET significantly decreased this isoprenaline-mediated induction of ANP, BNP and EPHX2.	11,12-epoxy-5,8,14-eicosatrienoic acid	14-23	epoxide hydrolase 2	Rattus norvegicus	101-106
22717287-0	2012	Upregulation of cytochrome P450 2J3/11,12-epoxyeicosatrienoic acid inhibits apoptosis in neonatal rat cardiomyocytes by a caspase-dependent pathway.	11,12-epoxy-5,8,14-eicosatrienoic acid	36-66	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	16-35
22717287-2	2012	The endogenous cytochrome P450 2J3/11,12-epoxyeicosatrienoic acid (CYP2J3/11,12-EET) is upregulated by IPost, but not IPC, in the rat heart.	11,12-epoxy-5,8,14-eicosatrienoic acid	35-65	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	15-34
22717287-2	2012	The endogenous cytochrome P450 2J3/11,12-epoxyeicosatrienoic acid (CYP2J3/11,12-EET) is upregulated by IPost, but not IPC, in the rat heart.	11,12-epoxy-5,8,14-eicosatrienoic acid	35-65	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	67-73
22184322-5	2012	In contrast, 11,12-epoxyeicosatrienoic acid, a Cyp2c44 metabolite, inhibited ENaC in the wt and Cyp2c44(-/-) mice.	11,12-epoxy-5,8,14-eicosatrienoic acid	13-43	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	77-81
22184322-5	2012	In contrast, 11,12-epoxyeicosatrienoic acid, a Cyp2c44 metabolite, inhibited ENaC in the wt and Cyp2c44(-/-) mice.	11,12-epoxy-5,8,14-eicosatrienoic acid	13-43	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	96-103
23029390-6	2012	Direct administration of 11,12-EET also increased pulmonary artery pressure, and both the sEH-I and 11,12-EET effects were prevented by iberiotoxin and absent in BKbeta(1)(-/-) mice.	11,12-epoxy-5,8,14-eicosatrienoic acid	25-34	epoxide hydrolase 2, cytoplasmic	Mus musculus	90-93
23029390-9	2012	In these cells, 11,12-EET elicited an iberiotoxin-sensitive loss of mitochondrial membrane potential (JC-1 fluorescence) leading to plasma membrane depolarization, an effect not observed in BKbeta(1)(-/-) cells.	11,12-epoxy-5,8,14-eicosatrienoic acid	16-25	potassium large conductance calcium-activated channel, subfamily M, beta member 1	Mus musculus	190-199
21697242-14	2011	We conclude that 11,12-EET, 8,9-EET, and 14,15-EET are endogenously formed eicosanoids that modulate ENaC activity in the collecting duct.	11,12-epoxy-5,8,14-eicosatrienoic acid	17-26	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	101-105
21846841-4	2011	11,12-EET pretreatment increased expression of the antioxidant enzymes superoxide dismutase and catalase and inhibited ATO-induced apoptosis.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	catalase	Homo sapiens	96-104
21846841-5	2011	11,12-EET also prevented the ATO-induced activation of p38 mitogen-activated protein kinase, c-Jun NH(2)-terminal kinase, caspase-3, and caspase-9.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	caspase 3	Homo sapiens	122-131
21846841-5	2011	11,12-EET also prevented the ATO-induced activation of p38 mitogen-activated protein kinase, c-Jun NH(2)-terminal kinase, caspase-3, and caspase-9.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	caspase 9	Homo sapiens	137-146
21697242-2	2011	Previous studies have indicated that arachidonic acid (AA) and its metabolite 11,12-EET but not other regioisomers of EETs inhibit ENaC activity in the collecting duct.	11,12-epoxy-5,8,14-eicosatrienoic acid	78-87	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	131-135
21167292-7	2011	Selective inhibition of CYP2C9 decreased tumor cell proliferation (KYSE30, PT1590 and OE19) in vitro, which was abolished by 11,12-epoxyeicosatrienoic acid (11,12-EET).	11,12-epoxy-5,8,14-eicosatrienoic acid	125-155	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	24-30
21697242-5	2011	Single-channel patch-clamp experiments revealed that 8,9-EET, 14,15-EET, and 11,12-EET all decrease ENaC activity.	11,12-epoxy-5,8,14-eicosatrienoic acid	77-86	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	100-104
21167292-7	2011	Selective inhibition of CYP2C9 decreased tumor cell proliferation (KYSE30, PT1590 and OE19) in vitro, which was abolished by 11,12-epoxyeicosatrienoic acid (11,12-EET).	11,12-epoxy-5,8,14-eicosatrienoic acid	157-166	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	24-30
19122972-6	2009	11,12-EET, a metabolite of AA via the cytochrome P450 epoxygenase pathway, significantly inhibited the ENaC NPo, whereas 20-HETE, a metabolite of AA via the hydroxylase pathway, only caused a small inhibition of the ENaC NPo, to a similar degree as that seen with ETYA and LA.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	103-107
19717402-9	2010	The prothrombotic effects of CYP2C9 inhibition in vivo were reversed by exogenous superfusion with 11,12-epoxyeicosatrienoic acids.	11,12-epoxy-5,8,14-eicosatrienoic acid	99-130	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	29-35
19617407-5	2009	Furthermore, 11,12-epoxyeicosatrienoic acid (EET), a putative endothelium-derived hyperpolarizing factor, activated a TRPV4-like cation current and hyperpolarized the membrane of vascular smooth muscle cells, resulting in the dilation of mesenteric arteries from WT mice.	11,12-epoxy-5,8,14-eicosatrienoic acid	13-43	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	118-123
19617407-5	2009	Furthermore, 11,12-epoxyeicosatrienoic acid (EET), a putative endothelium-derived hyperpolarizing factor, activated a TRPV4-like cation current and hyperpolarized the membrane of vascular smooth muscle cells, resulting in the dilation of mesenteric arteries from WT mice.	11,12-epoxy-5,8,14-eicosatrienoic acid	45-48	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	118-123
20804500-4	2010	An epidermal growth factor receptor (EGFR) kinase inhibitor (AG494) or a PI3 kinase inhibitor (LY294002) inhibited cell migration and reduced 11,12-EET-induced cell migration.	11,12-epoxy-5,8,14-eicosatrienoic acid	142-151	epidermal growth factor receptor	Homo sapiens	3-35
20804500-4	2010	An epidermal growth factor receptor (EGFR) kinase inhibitor (AG494) or a PI3 kinase inhibitor (LY294002) inhibited cell migration and reduced 11,12-EET-induced cell migration.	11,12-epoxy-5,8,14-eicosatrienoic acid	142-151	epidermal growth factor receptor	Homo sapiens	37-41
20804500-6	2010	11,12-EET induced cell stretching and myosin-actin microfilament formation as well as increased phosphorylation of EGFR and Akt (Ser473), while 14,15-EEZE inhibited these effects.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	myosin heavy chain 14	Homo sapiens	38-44
20804500-6	2010	11,12-EET induced cell stretching and myosin-actin microfilament formation as well as increased phosphorylation of EGFR and Akt (Ser473), while 14,15-EEZE inhibited these effects.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	epidermal growth factor receptor	Homo sapiens	115-119
20804500-6	2010	11,12-EET induced cell stretching and myosin-actin microfilament formation as well as increased phosphorylation of EGFR and Akt (Ser473), while 14,15-EEZE inhibited these effects.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	AKT serine/threonine kinase 1	Homo sapiens	124-127
20595684-7	2010	Instead, suppression of sEH activity seemed to be responsible for the 11,12-EET-mediated enhanced inhibition of ENaC in animals on a high-potassium diet.	11,12-epoxy-5,8,14-eicosatrienoic acid	70-79	epoxide hydrolase 2	Rattus norvegicus	24-27
20595684-10	2010	In conclusion, high dietary potassium enhances the inhibitory effect of AA and 11,12-EET on ENaC by increasing CYP epoxygenase activity and decreasing sEH activity, respectively.	11,12-epoxy-5,8,14-eicosatrienoic acid	79-88	epoxide hydrolase 2	Rattus norvegicus	151-154
19122972-6	2009	11,12-EET, a metabolite of AA via the cytochrome P450 epoxygenase pathway, significantly inhibited the ENaC NPo, whereas 20-HETE, a metabolite of AA via the hydroxylase pathway, only caused a small inhibition of the ENaC NPo, to a similar degree as that seen with ETYA and LA.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	216-220
19122972-9	2009	The opposite effects of 11,12-EET and prostaglandin (PG) implicate different mechanisms in regulation of ENaC activity by activation of epoxygenase and cyclooxygenase.	11,12-epoxy-5,8,14-eicosatrienoic acid	24-33	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	105-109
19105833-2	2008	One of the CYP2J2 products, 11, 12-epoxyeicosatrienoic acid, has several vasoprotective effects.	11,12-epoxy-5,8,14-eicosatrienoic acid	28-59	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	11-17
18340006-5	2008	11,12-EET treatment also increased EphB4 expression in isolated mouse mesenteric arteries as well as in the vessels that developed in 11,12-EET-impregnated Matrigel plugs.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	Eph receptor B4	Mus musculus	35-40
18776712-9	2008	Exogenous 11,12-EET and 14,15-DHET induced reporter activity in HUAEC and Hep3B cells concomitant with increased levels of hypoxia-inducible factor-1alpha (HIF-1alpha), which is a key factor in the hypoxia response, but 11,12-DHET and 14,15-EET did not.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-154
18776712-9	2008	Exogenous 11,12-EET and 14,15-DHET induced reporter activity in HUAEC and Hep3B cells concomitant with increased levels of hypoxia-inducible factor-1alpha (HIF-1alpha), which is a key factor in the hypoxia response, but 11,12-DHET and 14,15-EET did not.	11,12-epoxy-5,8,14-eicosatrienoic acid	10-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	156-166
18417544-5	2008	The notion that the inhibitory effect of AA was mediated by CYP epoxygenase-dependent metabolites was further supported by the observation that application of 100 nM 11,12-epoxyeicosatrienoic acid (EET) mimicked the effect of AA and inhibited the basolateral 18-pS K channels.	11,12-epoxy-5,8,14-eicosatrienoic acid	166-196	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	60-63
18417544-5	2008	The notion that the inhibitory effect of AA was mediated by CYP epoxygenase-dependent metabolites was further supported by the observation that application of 100 nM 11,12-epoxyeicosatrienoic acid (EET) mimicked the effect of AA and inhibited the basolateral 18-pS K channels.	11,12-epoxy-5,8,14-eicosatrienoic acid	198-201	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	60-63
18340006-3	2008	METHODS AND RESULTS: CYP2C9 overexpression as well as stimulation with 11,12-EET (up to 48 hours) time-dependently increased EphB4 expression in endothelial cells.	11,12-epoxy-5,8,14-eicosatrienoic acid	71-80	Eph receptor B4	Mus musculus	125-130
18192241-8	2008	Importantly, 11,12-EET-induced activation of Akt kinase and transactivation of the epidermal growth factor (EGF) receptor was also inhibited by SKI-II.	11,12-epoxy-5,8,14-eicosatrienoic acid	13-22	epidermal growth factor receptor	Homo sapiens	83-121
18192241-10	2008	Furthermore, knockdown of SK1 expression by specific siRNA also inhibited 11,12-EET-induced EC proliferation and migration, whereas SK2 siRNA knockdown was without effect.	11,12-epoxy-5,8,14-eicosatrienoic acid	74-83	sphingosine kinase 1	Homo sapiens	26-29
18192241-11	2008	CONCLUSION: These results suggest that SK1 is an important mediator of the 11,12-EET-induced angiogenic effects in human ECs.	11,12-epoxy-5,8,14-eicosatrienoic acid	75-84	sphingosine kinase 1	Homo sapiens	39-42
18288354-10	2008	These results indicate that 11,12-EET preconditioning and postconditioning can protect myocardium from IR injury by improving mitochondrial functions, up-regulating the activities of Na(+)-K(+)-ATPase and SDH, and down-regulating the activity of Ca(2+)-ATPase in mitochondria.	11,12-epoxy-5,8,14-eicosatrienoic acid	28-37	serine dehydratase	Rattus norvegicus	205-208
17932624-1	2008	The present study was to test the hypothesis that 11,12-epoxyeicosatrienoic acid (11,12-EET), a metabolic product of arachidonic acid by cytochrome P450 epoxygenase, regulates nitric oxide (NO) generation of the L-arginine/NO synthase (NOS) pathway in human platelets.	11,12-epoxy-5,8,14-eicosatrienoic acid	50-80	nitric oxide synthase 2	Homo sapiens	212-234
17932624-1	2008	The present study was to test the hypothesis that 11,12-epoxyeicosatrienoic acid (11,12-EET), a metabolic product of arachidonic acid by cytochrome P450 epoxygenase, regulates nitric oxide (NO) generation of the L-arginine/NO synthase (NOS) pathway in human platelets.	11,12-epoxy-5,8,14-eicosatrienoic acid	82-91	nitric oxide synthase 2	Homo sapiens	212-234
16234312-13	2006	Because 11,12-epoxyeicosatrienoic acid (11,12-EET) inhibits ENaC activity in the CCD (Wei Y, Lin DH, Kemp R, Yaddanapudi GSS, Nasjletti A, Falck JR, and Wang WH.	11,12-epoxy-5,8,14-eicosatrienoic acid	8-38	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	60-64
17164143-0	2007	11,12-epoxyeicosatrienoic acid stimulates heme-oxygenase-1 in endothelial cells.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-30	heme oxygenase 1	Rattus norvegicus	42-58
17164143-2	2007	Confocal microscopy analysis of immunostaining of HO-1 and HO-2 in cultured endothelial cells treated with 11,12-EET (1 microM) showed an increase in florescence of HO-1 protein in the various cellular compartments, but not of HO-2.	11,12-epoxy-5,8,14-eicosatrienoic acid	107-116	heme oxygenase 1	Rattus norvegicus	50-63
17164143-2	2007	Confocal microscopy analysis of immunostaining of HO-1 and HO-2 in cultured endothelial cells treated with 11,12-EET (1 microM) showed an increase in florescence of HO-1 protein in the various cellular compartments, but not of HO-2.	11,12-epoxy-5,8,14-eicosatrienoic acid	107-116	heme oxygenase 1	Rattus norvegicus	50-54
17164143-2	2007	Confocal microscopy analysis of immunostaining of HO-1 and HO-2 in cultured endothelial cells treated with 11,12-EET (1 microM) showed an increase in florescence of HO-1 protein in the various cellular compartments, but not of HO-2.	11,12-epoxy-5,8,14-eicosatrienoic acid	107-116	heme oxygenase 2	Rattus norvegicus	59-63
17164143-5	2007	Upregulation of HO-1 by 11,12-EET, as well as 8,9-EET, was associated with an increase in HO activity, which was inhibited by stannous mesoporphirin (10 microM).	11,12-epoxy-5,8,14-eicosatrienoic acid	24-33	heme oxygenase 1	Rattus norvegicus	16-20
16904368-6	2006	11,12-EET (5 muM) did not change TNP-ATP binding K(D) to GST-Kir6.2C, but B(max) was reduced by half.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	latexin	Homo sapiens	13-16
16904368-7	2006	The effect of 11,12-EET was dose-dependent, and 8,9- and 14,15-EETs were as effective as 11,12-EET in inhibiting TNP-ATP binding to GST-Kir6.2C.	11,12-epoxy-5,8,14-eicosatrienoic acid	14-23	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	132-143
16904368-7	2006	The effect of 11,12-EET was dose-dependent, and 8,9- and 14,15-EETs were as effective as 11,12-EET in inhibiting TNP-ATP binding to GST-Kir6.2C.	11,12-epoxy-5,8,14-eicosatrienoic acid	89-98	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	132-143
17652182-9	2007	Addition of 11,12-EET or 8-bromo-cAMP significantly reversed the MS-PPOH- or monoclonal antibody-induced changes in I(to,peak) and APD in CYP2J2 Tr cells.	11,12-epoxy-5,8,14-eicosatrienoic acid	12-21	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	138-144
16839864-2	2006	One of the CYP2J2 products, 11,12-epoxyeicosatrienoic acid, has several vasoprotective effects.	11,12-epoxy-5,8,14-eicosatrienoic acid	28-58	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	11-17
16234312-13	2006	Because 11,12-epoxyeicosatrienoic acid (11,12-EET) inhibits ENaC activity in the CCD (Wei Y, Lin DH, Kemp R, Yaddanapudi GSS, Nasjletti A, Falck JR, and Wang WH.	11,12-epoxy-5,8,14-eicosatrienoic acid	40-49	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	60-64
16234312-15	2006	Addition of 11,12-EET inhibited ENaC channels in the CCD in which adenosine-induced inhibition was blocked by AACOCF3.	11,12-epoxy-5,8,14-eicosatrienoic acid	12-21	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	32-36
15895105-6	2005	Bradykinin-induced myocyte hyperpolarizations were also reduced by 14,15-EEZE-mSI (14,15-EEZE-methylsulfonylimide) (5,6- and 14,15-EET antagonist), whereas those to exogenous 11,12-EET were unaffected.	11,12-epoxy-5,8,14-eicosatrienoic acid	175-184	kininogen 1	Homo sapiens	0-10
16141533-3	2005	The IC50 value for production of 11,12-epoxy-5,8,14-eicosatrienoic acid (11,12-EET) by CYP4A2 and 4A3 averaged 12.7 nM and 22.0 nM, respectively.	11,12-epoxy-5,8,14-eicosatrienoic acid	33-71	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	87-93
16141533-3	2005	The IC50 value for production of 11,12-epoxy-5,8,14-eicosatrienoic acid (11,12-EET) by CYP4A2 and 4A3 averaged 12.7 nM and 22.0 nM, respectively.	11,12-epoxy-5,8,14-eicosatrienoic acid	73-82	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	87-93
16269659-4	2005	In patch-clamp experiments using freshly isolated cerebral myocytes, outwardly rectifying whole-cell currents with properties consistent with those of expressed TRPV4 channels were evoked by the TRPV4 agonist 4alpha-phorbol 12,13-didecanoate (4alpha-PDD) (5 micromol/L) and the endothelium-derived arachidonic acid metabolite 11,12 epoxyeicosatrienoic acid (11,12 EET) (300 nmol/L).	11,12-epoxy-5,8,14-eicosatrienoic acid	326-356	transient receptor potential cation channel subfamily V member 4	Homo sapiens	161-166
16269659-4	2005	In patch-clamp experiments using freshly isolated cerebral myocytes, outwardly rectifying whole-cell currents with properties consistent with those of expressed TRPV4 channels were evoked by the TRPV4 agonist 4alpha-phorbol 12,13-didecanoate (4alpha-PDD) (5 micromol/L) and the endothelium-derived arachidonic acid metabolite 11,12 epoxyeicosatrienoic acid (11,12 EET) (300 nmol/L).	11,12-epoxy-5,8,14-eicosatrienoic acid	326-356	transient receptor potential cation channel subfamily V member 4	Homo sapiens	195-200
15652503-1	2005	Arachidonic acid is oxidized by cytochromes P450 2C (CYP2C) to epoxyeicosatrienoic acids (EETs), possessing vasoactive properties, with 11,12-EET as the endothelium derived hyperpolarization factor.	11,12-epoxy-5,8,14-eicosatrienoic acid	136-145	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	32-51
15652503-1	2005	Arachidonic acid is oxidized by cytochromes P450 2C (CYP2C) to epoxyeicosatrienoic acids (EETs), possessing vasoactive properties, with 11,12-EET as the endothelium derived hyperpolarization factor.	11,12-epoxy-5,8,14-eicosatrienoic acid	136-145	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	53-58
14592496-0	2003	11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-30	tumor necrosis factor	Homo sapiens	86-95
15545402-7	2004	The notion that the inhibitory effect of AA is mediated by CYP-epoxygenase-dependent metabolites is also supported by the observation that application of 200 nM 11,12-epoxyeicosatrienoic acid (EET) inhibited ENaC in the CCD.	11,12-epoxy-5,8,14-eicosatrienoic acid	161-191	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	59-62
15545402-7	2004	The notion that the inhibitory effect of AA is mediated by CYP-epoxygenase-dependent metabolites is also supported by the observation that application of 200 nM 11,12-epoxyeicosatrienoic acid (EET) inhibited ENaC in the CCD.	11,12-epoxy-5,8,14-eicosatrienoic acid	161-191	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	208-212
15545402-7	2004	The notion that the inhibitory effect of AA is mediated by CYP-epoxygenase-dependent metabolites is also supported by the observation that application of 200 nM 11,12-epoxyeicosatrienoic acid (EET) inhibited ENaC in the CCD.	11,12-epoxy-5,8,14-eicosatrienoic acid	193-196	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	59-62
15545402-7	2004	The notion that the inhibitory effect of AA is mediated by CYP-epoxygenase-dependent metabolites is also supported by the observation that application of 200 nM 11,12-epoxyeicosatrienoic acid (EET) inhibited ENaC in the CCD.	11,12-epoxy-5,8,14-eicosatrienoic acid	193-196	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	208-212
15545402-9	2004	Also, application of 11,12-EET can still reduce ENaC activity in the presence of MS-PPOH, suggesting that 11,12-EET is a mediator for the AA-induced inhibition of ENaC.	11,12-epoxy-5,8,14-eicosatrienoic acid	21-30	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	48-52
15545402-9	2004	Also, application of 11,12-EET can still reduce ENaC activity in the presence of MS-PPOH, suggesting that 11,12-EET is a mediator for the AA-induced inhibition of ENaC.	11,12-epoxy-5,8,14-eicosatrienoic acid	21-30	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	163-167
15545402-9	2004	Also, application of 11,12-EET can still reduce ENaC activity in the presence of MS-PPOH, suggesting that 11,12-EET is a mediator for the AA-induced inhibition of ENaC.	11,12-epoxy-5,8,14-eicosatrienoic acid	106-115	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	48-52
15545402-9	2004	Also, application of 11,12-EET can still reduce ENaC activity in the presence of MS-PPOH, suggesting that 11,12-EET is a mediator for the AA-induced inhibition of ENaC.	11,12-epoxy-5,8,14-eicosatrienoic acid	106-115	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	163-167
14718251-12	2004	We conclude that 11,12-EET is the likely mediator of A2A R-induced dilation of rat PGMV.	11,12-epoxy-5,8,14-eicosatrienoic acid	17-26	adenosine A2a receptor	Rattus norvegicus	53-58
14742258-8	2004	In both cases, CYP2C23 was the major isoform responsible for 11,12-EET formation.	11,12-epoxy-5,8,14-eicosatrienoic acid	61-70	cytochrome P450, family 2, subfamily c, polypeptide 23	Rattus norvegicus	15-22
14592496-0	2003	11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-30	vascular cell adhesion molecule 1	Homo sapiens	104-110
14592496-0	2003	11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression.	11,12-epoxy-5,8,14-eicosatrienoic acid	32-41	tumor necrosis factor	Homo sapiens	86-95
14592496-0	2003	11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression.	11,12-epoxy-5,8,14-eicosatrienoic acid	32-41	vascular cell adhesion molecule 1	Homo sapiens	104-110
12586744-1	2003	Cytochrome P450 (CYP) epoxygenase products, such as 11,12-epoxyeicosatrienoic acid (EET), stimulate endothelial cell proliferation.	11,12-epoxy-5,8,14-eicosatrienoic acid	52-82	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
12819236-12	2003	Finally, expression and activity of CYP450 enzymes was elevated in CBDL kidneys, resulting in significantly greater production of the vasodilating 11,12-EET and 14,15-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	147-156	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	36-42
12582005-10	2003	The cytochrome P-450 epoxyeicosatrienoic acid (EET) metabolite 14,15-EET (5 x 10(-7) M) inhibited both apical and basolateral cotransport, whereas 8,9-EET and 11,12-EET had no significant effect.	11,12-epoxy-5,8,14-eicosatrienoic acid	159-168	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	4-20
14529287-4	2003	Rat heart FABP (H-FABP) and rat liver FABP were potent inhibitors of 11,12-EET and 14,15-EET conversion to DHET.	11,12-epoxy-5,8,14-eicosatrienoic acid	69-78	fatty acid binding protein 2	Rattus norvegicus	10-14
14529287-4	2003	Rat heart FABP (H-FABP) and rat liver FABP were potent inhibitors of 11,12-EET and 14,15-EET conversion to DHET.	11,12-epoxy-5,8,14-eicosatrienoic acid	69-78	fatty acid binding protein 3	Rattus norvegicus	16-22
14529287-4	2003	Rat heart FABP (H-FABP) and rat liver FABP were potent inhibitors of 11,12-EET and 14,15-EET conversion to DHET.	11,12-epoxy-5,8,14-eicosatrienoic acid	69-78	fatty acid binding protein 2	Rattus norvegicus	18-22
14529287-5	2003	The resultant inhibition curves were best described by a substrate depletion model, with K(d) = 0.17 +/- 0.01 microM for H-FABP binding to 11,12-EET, suggesting that FABP acts by reducing EET availability to sEH.	11,12-epoxy-5,8,14-eicosatrienoic acid	139-148	fatty acid binding protein 3	Rattus norvegicus	121-127
14529287-5	2003	The resultant inhibition curves were best described by a substrate depletion model, with K(d) = 0.17 +/- 0.01 microM for H-FABP binding to 11,12-EET, suggesting that FABP acts by reducing EET availability to sEH.	11,12-epoxy-5,8,14-eicosatrienoic acid	139-148	fatty acid binding protein 2	Rattus norvegicus	123-127
14529287-5	2003	The resultant inhibition curves were best described by a substrate depletion model, with K(d) = 0.17 +/- 0.01 microM for H-FABP binding to 11,12-EET, suggesting that FABP acts by reducing EET availability to sEH.	11,12-epoxy-5,8,14-eicosatrienoic acid	139-148	epoxide hydrolase 2	Rattus norvegicus	208-211
12773534-0	2003	11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-30	cyclin dependent kinase inhibitor 1B	Homo sapiens	120-127
12773534-3	2003	Incubation of human umbilical vein endothelial cells with 11,12-EET induced a time- and dose-dependent decrease in p27Kip1 protein expression, whereas p21Cip1 was not significantly affected.	11,12-epoxy-5,8,14-eicosatrienoic acid	58-67	cyclin dependent kinase inhibitor 1B	Homo sapiens	115-122
12773534-5	2003	11,12-EET also stimulated the time-dependent phosphorylation of Akt and of the forkhead factors FOXO1 and FOXO3a, effects prevented by the phosphatidylinositol 3-kinase inhibitor LY 294002.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	AKT serine/threonine kinase 1	Homo sapiens	64-67
12773534-5	2003	11,12-EET also stimulated the time-dependent phosphorylation of Akt and of the forkhead factors FOXO1 and FOXO3a, effects prevented by the phosphatidylinositol 3-kinase inhibitor LY 294002.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	forkhead box O1	Homo sapiens	96-101
12773534-5	2003	11,12-EET also stimulated the time-dependent phosphorylation of Akt and of the forkhead factors FOXO1 and FOXO3a, effects prevented by the phosphatidylinositol 3-kinase inhibitor LY 294002.	11,12-epoxy-5,8,14-eicosatrienoic acid	0-9	forkhead box O3	Homo sapiens	106-112
12773534-6	2003	Transfection of endothelial cells with either a dominant-negative or an "Akt-resistant"/constitutively active FOXO3a mutant reversed the 11,12-EET-induced down-regulation of p27Kip1, whereas transfection of a constitutive active Akt decreased p27Kip1 expression independently of the presence or absence of 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	137-146	AKT serine/threonine kinase 1	Homo sapiens	73-76
12773534-6	2003	Transfection of endothelial cells with either a dominant-negative or an "Akt-resistant"/constitutively active FOXO3a mutant reversed the 11,12-EET-induced down-regulation of p27Kip1, whereas transfection of a constitutive active Akt decreased p27Kip1 expression independently of the presence or absence of 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	137-146	forkhead box O3	Homo sapiens	110-116
12773534-6	2003	Transfection of endothelial cells with either a dominant-negative or an "Akt-resistant"/constitutively active FOXO3a mutant reversed the 11,12-EET-induced down-regulation of p27Kip1, whereas transfection of a constitutive active Akt decreased p27Kip1 expression independently of the presence or absence of 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	137-146	cyclin dependent kinase inhibitor 1B	Homo sapiens	174-181
12773534-6	2003	Transfection of endothelial cells with either a dominant-negative or an "Akt-resistant"/constitutively active FOXO3a mutant reversed the 11,12-EET-induced down-regulation of p27Kip1, whereas transfection of a constitutive active Akt decreased p27Kip1 expression independently of the presence or absence of 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	137-146	AKT serine/threonine kinase 1	Homo sapiens	229-232
12773534-6	2003	Transfection of endothelial cells with either a dominant-negative or an "Akt-resistant"/constitutively active FOXO3a mutant reversed the 11,12-EET-induced down-regulation of p27Kip1, whereas transfection of a constitutive active Akt decreased p27Kip1 expression independently of the presence or absence of 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	137-146	cyclin dependent kinase inhibitor 1B	Homo sapiens	243-250
12773534-6	2003	Transfection of endothelial cells with either a dominant-negative or an "Akt-resistant"/constitutively active FOXO3a mutant reversed the 11,12-EET-induced down-regulation of p27Kip1, whereas transfection of a constitutive active Akt decreased p27Kip1 expression independently of the presence or absence of 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	306-315	forkhead box O3	Homo sapiens	110-116
12876297-1	2003	Cytochrome P-450 monooxygenase (epoxygenase)-derived arachidonic acid (AA) metabolites, including 11,12-epoxyeicosatrienoic acid (11,12-EET), possess anti-inflammatory and antipyretic properties.	11,12-epoxy-5,8,14-eicosatrienoic acid	98-128	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	0-30
12876297-1	2003	Cytochrome P-450 monooxygenase (epoxygenase)-derived arachidonic acid (AA) metabolites, including 11,12-epoxyeicosatrienoic acid (11,12-EET), possess anti-inflammatory and antipyretic properties.	11,12-epoxy-5,8,14-eicosatrienoic acid	130-139	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	0-30
12876297-9	2003	Preincubation of a murine COX-2 preparation for 0-5 min with three concentrations of 11,12-EET (1, 5, and 10 microM) inhibited the oxygenation of [14C]-labeled AA by the enzyme.	11,12-epoxy-5,8,14-eicosatrienoic acid	85-94	cytochrome c oxidase II, mitochondrial	Mus musculus	26-31
12876297-10	2003	The inhibitory effect of 11,12-EET on COX-2 was time-and-concentration-dependent, suggesting a mechanism-based inhibition.	11,12-epoxy-5,8,14-eicosatrienoic acid	25-34	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	38-43
12586744-1	2003	Cytochrome P450 (CYP) epoxygenase products, such as 11,12-epoxyeicosatrienoic acid (EET), stimulate endothelial cell proliferation.	11,12-epoxy-5,8,14-eicosatrienoic acid	52-82	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
12586744-1	2003	Cytochrome P450 (CYP) epoxygenase products, such as 11,12-epoxyeicosatrienoic acid (EET), stimulate endothelial cell proliferation.	11,12-epoxy-5,8,14-eicosatrienoic acid	84-87	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-15
12586744-1	2003	Cytochrome P450 (CYP) epoxygenase products, such as 11,12-epoxyeicosatrienoic acid (EET), stimulate endothelial cell proliferation.	11,12-epoxy-5,8,14-eicosatrienoic acid	84-87	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	17-20
11585587-0	2001	Hypothalamic 11,12-epoxyeicosatrienoic acid attenuates fever induced by central interleukin-1beta in the rat.	11,12-epoxy-5,8,14-eicosatrienoic acid	13-43	interleukin 1 beta	Rattus norvegicus	80-97
12124379-5	2002	CYP4A1 exhibited a preference for 8,9-EET, whereas CYP4A2, CYP4A3, and CYP4A8 preferred 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	88-97	cytochrome P450 family 4 subfamily A member 11	Homo sapiens	51-57
11867622-10	2002	Overexpression of CYP 2C9 significantly increased the expression of MKP-1, as did incubation with 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	98-107	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	18-25
11867622-10	2002	Overexpression of CYP 2C9 significantly increased the expression of MKP-1, as did incubation with 11,12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	98-107	dual specificity phosphatase 1	Homo sapiens	68-73
11893556-2	2002	The present study determined whether these novel signaling nucleotides participate in 11,12-epoxyeicosatrienoic acid (11,12-EET)-induced activation of the K(Ca) channels in CASMCs.	11,12-epoxy-5,8,14-eicosatrienoic acid	86-116	casein kappa	Homo sapiens	155-160
11893556-2	2002	The present study determined whether these novel signaling nucleotides participate in 11,12-epoxyeicosatrienoic acid (11,12-EET)-induced activation of the K(Ca) channels in CASMCs.	11,12-epoxy-5,8,14-eicosatrienoic acid	118-127	casein kappa	Homo sapiens	155-160
11893556-9	2002	The NAD glycohydrolase inhibitor cibacron blue 3GA (3GA, 100 microM) significantly attenuated 11,12-EET-induced increase in the K(Ca) channel activity in CASMCs.	11,12-epoxy-5,8,14-eicosatrienoic acid	94-103	casein kappa	Homo sapiens	128-133
11893556-13	2002	These results indicate that 11,12-EET stimulates the production of ADPR and that intracellular ADPR is an important signaling molecule mediating 11,12-EET-induced activation of the K(Ca) channels in CASMCs and consequently results in vasodilation of coronary artery.	11,12-epoxy-5,8,14-eicosatrienoic acid	28-37	casein kappa	Homo sapiens	181-186
11893556-13	2002	These results indicate that 11,12-EET stimulates the production of ADPR and that intracellular ADPR is an important signaling molecule mediating 11,12-EET-induced activation of the K(Ca) channels in CASMCs and consequently results in vasodilation of coronary artery.	11,12-epoxy-5,8,14-eicosatrienoic acid	145-154	casein kappa	Homo sapiens	181-186
12016269-8	2002	Indeed, forskolin and 8-bromo-cAMP exert similar inhibitory effects on SMC migration as 11,12-EET and the effects of 11,12-EET were blocked by cAMP and protein kinase A (PKA) inhibitors.	11,12-epoxy-5,8,14-eicosatrienoic acid	88-97	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	170-173
12016269-8	2002	Indeed, forskolin and 8-bromo-cAMP exert similar inhibitory effects on SMC migration as 11,12-EET and the effects of 11,12-EET were blocked by cAMP and protein kinase A (PKA) inhibitors.	11,12-epoxy-5,8,14-eicosatrienoic acid	117-126	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	152-168
12016269-8	2002	Indeed, forskolin and 8-bromo-cAMP exert similar inhibitory effects on SMC migration as 11,12-EET and the effects of 11,12-EET were blocked by cAMP and protein kinase A (PKA) inhibitors.	11,12-epoxy-5,8,14-eicosatrienoic acid	117-126	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	170-173
11393683-0	2001	Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid.	11,12-epoxy-5,8,14-eicosatrienoic acid	118-148	angiotensinogen	Rattus norvegicus	43-57
11510882-6	2001	The CYP 2C product 11,12-epoxyeicosatrienoic acid (11,12-EET) also activated tyrosine kinases, Erk1/2 and p38 MAP kinase.	11,12-epoxy-5,8,14-eicosatrienoic acid	19-49	mitogen-activated protein kinase 3	Homo sapiens	95-101
11510882-6	2001	The CYP 2C product 11,12-epoxyeicosatrienoic acid (11,12-EET) also activated tyrosine kinases, Erk1/2 and p38 MAP kinase.	11,12-epoxy-5,8,14-eicosatrienoic acid	19-49	mitogen-activated protein kinase 14	Homo sapiens	106-120
11510882-6	2001	The CYP 2C product 11,12-epoxyeicosatrienoic acid (11,12-EET) also activated tyrosine kinases, Erk1/2 and p38 MAP kinase.	11,12-epoxy-5,8,14-eicosatrienoic acid	51-60	mitogen-activated protein kinase 3	Homo sapiens	95-101
11510882-6	2001	The CYP 2C product 11,12-epoxyeicosatrienoic acid (11,12-EET) also activated tyrosine kinases, Erk1/2 and p38 MAP kinase.	11,12-epoxy-5,8,14-eicosatrienoic acid	51-60	mitogen-activated protein kinase 14	Homo sapiens	106-120
11510882-7	2001	Overexpression of CYP 2C8 in native porcine coronary artery endothelial cells resulted in an increase in endothelial 11,12-EET production and Erk1/2 phosphorylation compared to that detected in untreated cells or cells transfected with an antisense CYP 2C8.	11,12-epoxy-5,8,14-eicosatrienoic acid	117-126	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	18-25
11279071-3	2001	In vascular endothelial cells, physiological concentrations of EETs, particularly 11,12-EET, or overexpression of the endothelial epoxygenase, CYP2J2, increased tissue plasminogen activator (t-PA) expression by 2.5-fold without affecting plasminogen activator inhibitor-1 expression.	11,12-epoxy-5,8,14-eicosatrienoic acid	82-91	plasminogen activator, tissue type	Homo sapiens	161-195
11393683-12	2001	Interestingly, elevation of 11,12-EET-SI levels to 100 nmol reversed the enhanced vascular reactivity to angiotensin II associated with angiotensin II hypertension.	11,12-epoxy-5,8,14-eicosatrienoic acid	28-37	angiotensinogen	Rattus norvegicus	105-119
11393683-12	2001	Interestingly, elevation of 11,12-EET-SI levels to 100 nmol reversed the enhanced vascular reactivity to angiotensin II associated with angiotensin II hypertension.	11,12-epoxy-5,8,14-eicosatrienoic acid	28-37	angiotensinogen	Rattus norvegicus	136-150
10519554-3	1999	Here we show that the induction of cytochrome P450 (CYP) 2C8/34 in native porcine coronary artery endothelial cells by beta-naphthoflavone enhances the formation of 11,12-epoxyeicosatrienoic acid, as well as EDHF-mediated hyperpolarization and relaxation.	11,12-epoxy-5,8,14-eicosatrienoic acid	165-195	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	35-60
11170430-8	2001	H-FABP affinity for 5,6-EET and 11,12-EET (K(d)" of approximately 0.4 microM) was approximately 20-fold greater than for DHETs (K(d)" of approximately 8 microM).	11,12-epoxy-5,8,14-eicosatrienoic acid	32-41	fatty acid binding protein 3	Homo sapiens	0-6
9931138-1	1999	The current study determined the contribution of protein kinase-A (PKA) and protein kinase-G (PKG) to the vasodilation elicited by the N-methylsulfonimide analog of 11,12-epoxyeicosatrienoic acid (11, 12-EET).	11,12-epoxy-5,8,14-eicosatrienoic acid	165-195	protein kinase cGMP-dependent 1	Homo sapiens	76-92
10362749-10	1999	Moreover, the ability of CYP4A2 and -4A3 to catalyze the formation of two opposing biologically active metabolites, 20-HETE and 11, 12-epoxyeicosatrienoic acid, may be of great significance to the regulation of vascular tone.	11,12-epoxy-5,8,14-eicosatrienoic acid	128-159	cytochrome P450, family 4, subfamily a, polypeptide 2	Rattus norvegicus	25-31
9931138-1	1999	The current study determined the contribution of protein kinase-A (PKA) and protein kinase-G (PKG) to the vasodilation elicited by the N-methylsulfonimide analog of 11,12-epoxyeicosatrienoic acid (11, 12-EET).	11,12-epoxy-5,8,14-eicosatrienoic acid	165-195	protein kinase cGMP-dependent 1	Homo sapiens	94-97
9931138-1	1999	The current study determined the contribution of protein kinase-A (PKA) and protein kinase-G (PKG) to the vasodilation elicited by the N-methylsulfonimide analog of 11,12-epoxyeicosatrienoic acid (11, 12-EET).	11,12-epoxy-5,8,14-eicosatrienoic acid	197-207	protein kinase cGMP-dependent 1	Homo sapiens	94-97
9781934-12	1998	Both 14,15-epoxyeicosatrienoic acid (EET) and 11,12-EET increased the open probabilities of K(Ca) channels in cell-attached patches.	11,12-epoxy-5,8,14-eicosatrienoic acid	46-55	casein kappa	Homo sapiens	92-97
9242187-6	1997	Preincubation with 14,15-EET, 11,12-EET, 14,15-DHET, and 11,12-DHET augmented the magnitude and duration of bradykinin-induced relaxation, whereas endothelium-independent relaxations to aprikalim and sodium nitroprusside were not potentiated.	11,12-epoxy-5,8,14-eicosatrienoic acid	30-39	kininogen 1	Homo sapiens	108-118
9721182-6	1998	Based on coelution with authentic standards on reverse-phase HPLC, themajor metabolites were tentatively identified asfollows: CYP2C29 and CYP2C39 produced 14, 15-cis-epoxyeicosatrienoic acid (EET); CYP2C37 produced 12-hydroxyeicosatetraenoic acid (HETE); CYP2C38 produced 11,12-EET; and CYP2C40 produced an unidentified metabolite that coeluted with 16-,17-, and 18-HETEs.	11,12-epoxy-5,8,14-eicosatrienoic acid	273-282	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	127-134
9721182-6	1998	Based on coelution with authentic standards on reverse-phase HPLC, themajor metabolites were tentatively identified asfollows: CYP2C29 and CYP2C39 produced 14, 15-cis-epoxyeicosatrienoic acid (EET); CYP2C37 produced 12-hydroxyeicosatetraenoic acid (HETE); CYP2C38 produced 11,12-EET; and CYP2C40 produced an unidentified metabolite that coeluted with 16-,17-, and 18-HETEs.	11,12-epoxy-5,8,14-eicosatrienoic acid	273-282	cytochrome P450, family 2, subfamily c, polypeptide 39	Mus musculus	139-146
9721182-6	1998	Based on coelution with authentic standards on reverse-phase HPLC, themajor metabolites were tentatively identified asfollows: CYP2C29 and CYP2C39 produced 14, 15-cis-epoxyeicosatrienoic acid (EET); CYP2C37 produced 12-hydroxyeicosatetraenoic acid (HETE); CYP2C38 produced 11,12-EET; and CYP2C40 produced an unidentified metabolite that coeluted with 16-,17-, and 18-HETEs.	11,12-epoxy-5,8,14-eicosatrienoic acid	273-282	cytochrome P450, family 2. subfamily c, polypeptide 37	Mus musculus	199-206
9721182-6	1998	Based on coelution with authentic standards on reverse-phase HPLC, themajor metabolites were tentatively identified asfollows: CYP2C29 and CYP2C39 produced 14, 15-cis-epoxyeicosatrienoic acid (EET); CYP2C37 produced 12-hydroxyeicosatetraenoic acid (HETE); CYP2C38 produced 11,12-EET; and CYP2C40 produced an unidentified metabolite that coeluted with 16-,17-, and 18-HETEs.	11,12-epoxy-5,8,14-eicosatrienoic acid	273-282	cytochrome P450, family 2, subfamily c, polypeptide 38	Mus musculus	256-263
9721182-6	1998	Based on coelution with authentic standards on reverse-phase HPLC, themajor metabolites were tentatively identified asfollows: CYP2C29 and CYP2C39 produced 14, 15-cis-epoxyeicosatrienoic acid (EET); CYP2C37 produced 12-hydroxyeicosatetraenoic acid (HETE); CYP2C38 produced 11,12-EET; and CYP2C40 produced an unidentified metabolite that coeluted with 16-,17-, and 18-HETEs.	11,12-epoxy-5,8,14-eicosatrienoic acid	273-282	cytochrome P450, family 2, subfamily c, polypeptide 40	Mus musculus	288-295
9518732-20	1998	Extracellular administration of 11, 12-epoxyeicosatrienoic acid, one of the P450-mediated metabolites of arachidonic acid, enhanced ICa and intracellular cAMP content.	11,12-epoxy-5,8,14-eicosatrienoic acid	32-63	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	76-80
9139707-11	1997	Based on these data, we conclude that (a) CYP2J3 is one of the predominant enzymes responsible for the oxidation of endogenous arachidonic acid pools in rat heart myocytes and (b) 11,12-epoxyeicosatrienoic acid may play an important functional role in the response of the heart to ischemia.	11,12-epoxy-5,8,14-eicosatrienoic acid	180-210	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	42-48
8954571-13	1996	Microsomes prepared from isolated renal microvessels selectively expressed CYP4A2 protein and readily metabolized arachidonic acid to two major metabolites, 20-HETE and 11,12-DHET, the hydrolytic metabolite of 11, 12-EET.	11,12-epoxy-5,8,14-eicosatrienoic acid	210-220	cytochrome P450, family 4, subfamily a, polypeptide 2	Rattus norvegicus	75-81