PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32770329-7	2021	Lycopene application significantly increased the expression levels of the Ku70 and Ku80 genes which have a part in DNA repair (p < 0.05).	Lycopene	0-8	X-ray repair cross complementing 6	Rattus norvegicus	74-78
1261549-3	1976	From quantitative analyses of carotenes and nuclear proportions in the heterokaryons we conclude that four copies of the carB gene product, assembled in an enzyme complex, act sequentially in the conversion of phytoene to lycopene.	Lycopene	222-230	syntaxin 8	Homo sapiens	121-125
33908429-0	2021	Lycopene attenuates di(2-ethylhexyl) phthalate-induced mitophagy in spleen by regulating the sirtuin3-mediated pathway.	Lycopene	0-8	sirtuin 3	Mus musculus	93-101
34018317-6	2021	Under high-fat diet, lycopene reduced the levels of IL-17, IL-6 and TNF-alpha in placenta (P<0.05) through the IL-17 pathway.	Lycopene	21-29	interleukin 17A	Rattus norvegicus	52-57
34018317-6	2021	Under high-fat diet, lycopene reduced the levels of IL-17, IL-6 and TNF-alpha in placenta (P<0.05) through the IL-17 pathway.	Lycopene	21-29	interleukin 6	Rattus norvegicus	59-63
34018317-6	2021	Under high-fat diet, lycopene reduced the levels of IL-17, IL-6 and TNF-alpha in placenta (P<0.05) through the IL-17 pathway.	Lycopene	21-29	tumor necrosis factor	Rattus norvegicus	68-77
34018317-6	2021	Under high-fat diet, lycopene reduced the levels of IL-17, IL-6 and TNF-alpha in placenta (P<0.05) through the IL-17 pathway.	Lycopene	21-29	interleukin 17A	Rattus norvegicus	111-116
34018317-7	2021	Furthermore, lycopene supplementation in high-fat diet increased Glrx gene and protein expression in the placenta (P<0.05), increased GSH-Px and T-AOC levels (P<0.05), decreased ROS (P<0.01) and H2 O2 levels (P<0.05) in placenta.	Lycopene	13-21	glutaredoxin	Rattus norvegicus	65-69
34018317-8	2021	In addition, lycopene supplementation in high fat diet increased the expression of Lep gene and protein in placenta and increase the level of leptin (P<0.05).	Lycopene	13-21	leptin	Rattus norvegicus	83-86
34018317-8	2021	In addition, lycopene supplementation in high fat diet increased the expression of Lep gene and protein in placenta and increase the level of leptin (P<0.05).	Lycopene	13-21	leptin	Rattus norvegicus	142-148
33975324-0	2021	Lycopene and Caffeic Acid Phenethyl Ester Affect Caspase-3 Activity, but Do Not Alter the NO Pathway in Lung Tissue Damage Induced by Cisplatin.	Lycopene	0-8	caspase 3	Rattus norvegicus	49-58
33960999-0	2021	AQP2 as a target of lycopene protects against atrazine-induced renal ionic homeostasis disturbance.	Lycopene	20-28	aquaporin 2	Mus musculus	0-4
33948854-6	2021	The anti-oxidant effect of lycopene was determined by measuring superoxide dismutase (SOD), catalase (CAT) hydrogen peroxide (H2O2), malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS).	Lycopene	27-35	superoxide dismutase 1	Homo sapiens	64-84
33948854-6	2021	The anti-oxidant effect of lycopene was determined by measuring superoxide dismutase (SOD), catalase (CAT) hydrogen peroxide (H2O2), malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS).	Lycopene	27-35	superoxide dismutase 1	Homo sapiens	86-89
33948854-6	2021	The anti-oxidant effect of lycopene was determined by measuring superoxide dismutase (SOD), catalase (CAT) hydrogen peroxide (H2O2), malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS).	Lycopene	27-35	catalase	Homo sapiens	92-100
33948854-6	2021	The anti-oxidant effect of lycopene was determined by measuring superoxide dismutase (SOD), catalase (CAT) hydrogen peroxide (H2O2), malondialdehyde (MDA), total antioxidant status (TAS) and total oxidant status (TOS).	Lycopene	27-35	catalase	Homo sapiens	102-105
33998846-7	2021	Also, only lycopene (WMD: -1.08 pg/ml, 95%CI: -2.03, -0.12, P = 0.027) led to a significant decrease in IL-6.	Lycopene	11-19	interleukin 6	Homo sapiens	104-108
34055003-0	2021	Lycopene Attenuates Hypoxia-Induced Testicular Injury by Inhibiting PROK2 Expression and Activating PI3K/AKT/mTOR Pathway in a Varicocele Adult Rat.	Lycopene	0-8	prokineticin 2	Rattus norvegicus	68-73
34055003-0	2021	Lycopene Attenuates Hypoxia-Induced Testicular Injury by Inhibiting PROK2 Expression and Activating PI3K/AKT/mTOR Pathway in a Varicocele Adult Rat.	Lycopene	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	105-108
34055003-0	2021	Lycopene Attenuates Hypoxia-Induced Testicular Injury by Inhibiting PROK2 Expression and Activating PI3K/AKT/mTOR Pathway in a Varicocele Adult Rat.	Lycopene	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	109-113
34055003-8	2021	Prokineticin 2(PROK2) and prokineticin receptor 2 (PROKR2) were overexpressed in VG (P < 0.01), and lycopene inhibited the PROK2 expression (P < 0.01).	Lycopene	100-108	prokineticin 2	Rattus norvegicus	123-128
34055003-9	2021	Proliferating cell nuclear antigen (PCNA) and sex hormones were increased by lycopene in VLG (P < 0.05).	Lycopene	77-85	proliferating cell nuclear antigen	Rattus norvegicus	0-34
34055003-9	2021	Proliferating cell nuclear antigen (PCNA) and sex hormones were increased by lycopene in VLG (P < 0.05).	Lycopene	77-85	proliferating cell nuclear antigen	Rattus norvegicus	36-40
34055003-10	2021	Lycopene restored the quality and activity of sperm by blocking PROK2 expression (P < 0.05).	Lycopene	0-8	prokineticin 2	Rattus norvegicus	64-69
34055003-13	2021	In addition, lycopene reduced levels of interleukin-1beta (IL-1beta) and interleukin-2 (IL-2) in VLG (P < 0.05), compared to NG.	Lycopene	13-21	interleukin 1 beta	Rattus norvegicus	40-57
34055003-13	2021	In addition, lycopene reduced levels of interleukin-1beta (IL-1beta) and interleukin-2 (IL-2) in VLG (P < 0.05), compared to NG.	Lycopene	13-21	interleukin 1 alpha	Rattus norvegicus	59-67
34055003-13	2021	In addition, lycopene reduced levels of interleukin-1beta (IL-1beta) and interleukin-2 (IL-2) in VLG (P < 0.05), compared to NG.	Lycopene	13-21	interleukin 2	Rattus norvegicus	73-86
34055003-13	2021	In addition, lycopene reduced levels of interleukin-1beta (IL-1beta) and interleukin-2 (IL-2) in VLG (P < 0.05), compared to NG.	Lycopene	13-21	interleukin 2	Rattus norvegicus	88-92
34055003-14	2021	Conclusions: Lycopene improved the hypoxia-induced testicular injury by inhibiting the expression of PROK2 and decreasing levels of IL-1beta and IL-2, which might show us a novel and promising treatment for varicocele testicular injury.	Lycopene	13-21	prokineticin 2	Rattus norvegicus	101-106
34055003-14	2021	Conclusions: Lycopene improved the hypoxia-induced testicular injury by inhibiting the expression of PROK2 and decreasing levels of IL-1beta and IL-2, which might show us a novel and promising treatment for varicocele testicular injury.	Lycopene	13-21	interleukin 1 alpha	Rattus norvegicus	132-140
34055003-14	2021	Conclusions: Lycopene improved the hypoxia-induced testicular injury by inhibiting the expression of PROK2 and decreasing levels of IL-1beta and IL-2, which might show us a novel and promising treatment for varicocele testicular injury.	Lycopene	13-21	interleukin 2	Rattus norvegicus	145-149
32770329-7	2021	Lycopene application significantly increased the expression levels of the Ku70 and Ku80 genes which have a part in DNA repair (p < 0.05).	Lycopene	0-8	X-ray repair cross complementing 5	Rattus norvegicus	83-87
33932206-9	2021	The lycopene + BPA group showed significantly reduced mean percentage of 8-OHdG immunopositive and mean area percentages of Bax and caspase 3 immunopositive cells and significantly reduced mean area percentage of Bcl2 immunopositive cells as compared with the BPA group.	Lycopene	4-12	BCL2 associated X, apoptosis regulator	Rattus norvegicus	124-127
33932206-9	2021	The lycopene + BPA group showed significantly reduced mean percentage of 8-OHdG immunopositive and mean area percentages of Bax and caspase 3 immunopositive cells and significantly reduced mean area percentage of Bcl2 immunopositive cells as compared with the BPA group.	Lycopene	4-12	caspase 3	Rattus norvegicus	132-141
33932206-9	2021	The lycopene + BPA group showed significantly reduced mean percentage of 8-OHdG immunopositive and mean area percentages of Bax and caspase 3 immunopositive cells and significantly reduced mean area percentage of Bcl2 immunopositive cells as compared with the BPA group.	Lycopene	4-12	BCL2, apoptosis regulator	Rattus norvegicus	213-217
33987329-5	2021	Lycopene inhibited F4/80+ macrophage and Ly6G+ neutrophil accumulation, which further decreased the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin 6 (IL-6).	Lycopene	0-8	interleukin 1 alpha	Mus musculus	170-178
33548472-6	2021	Interestingly, a major lycopene cleavage enzyme, beta-carotene 9",10"-oxygenase (BCO2), which recently has been recognized to play metabolic roles beyond cleavage function, was down-regulated by NNK/CS exposure, but this decrease was prevented by lycopene feeding.	Lycopene	23-31	beta,beta-carotene 9',10'-oxygenase	Mustela putorius furo	81-85
33548472-6	2021	Interestingly, a major lycopene cleavage enzyme, beta-carotene 9",10"-oxygenase (BCO2), which recently has been recognized to play metabolic roles beyond cleavage function, was down-regulated by NNK/CS exposure, but this decrease was prevented by lycopene feeding.	Lycopene	247-255	beta,beta-carotene 9',10'-oxygenase	Mustela putorius furo	81-85
33548472-8	2021	In conclusion, our results suggest that CS can promote development of NASH and liver fibrosis in ferrets, which is associated with downregulation of BCO2 and impairment of antioxidant system in liver; dietary lycopene may inhibit CS-promoted NASH by preventing suppression of BCO2 and decline in antioxidant network.	Lycopene	209-217	beta,beta-carotene 9',10'-oxygenase	Mustela putorius furo	276-280
33965855-0	2021	Lycopene prevents DEHP-induced hepatic oxidative stress damage by crosstalk between AHR-Nrf2 pathway.	Lycopene	0-8	aryl-hydrocarbon receptor	Mus musculus	84-87
33965855-0	2021	Lycopene prevents DEHP-induced hepatic oxidative stress damage by crosstalk between AHR-Nrf2 pathway.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	88-92
33987329-0	2021	Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	64-68
33987329-0	2021	Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells.	Lycopene	0-8	heme oxygenase 1	Mus musculus	69-73
33987329-5	2021	Lycopene inhibited F4/80+ macrophage and Ly6G+ neutrophil accumulation, which further decreased the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin 6 (IL-6).	Lycopene	0-8	interleukin 6	Mus musculus	185-198
33987329-0	2021	Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells.	Lycopene	0-8	NLR family, pyrin domain containing 3	Mus musculus	91-96
33987329-5	2021	Lycopene inhibited F4/80+ macrophage and Ly6G+ neutrophil accumulation, which further decreased the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin 6 (IL-6).	Lycopene	0-8	interleukin 6	Mus musculus	200-204
33987329-4	2021	Results: In this study, we observed that the levels of aspartate aminotransferases (AST), alanine aminotransferase (ALT), and the percentages of hepatocellular apoptosis in mice pretreated with lycopene were significantly lower than control mice.	Lycopene	194-202	glutamic pyruvic transaminase, soluble	Mus musculus	90-114
33987329-6	2021	Interestingly, lycopene induced increased autophagy in KCs, which was evidenced by elevated autophagosomes and the increased protein level of LC3B.	Lycopene	15-23	microtubule-associated protein 1 light chain 3 beta	Mus musculus	142-146
33987329-4	2021	Results: In this study, we observed that the levels of aspartate aminotransferases (AST), alanine aminotransferase (ALT), and the percentages of hepatocellular apoptosis in mice pretreated with lycopene were significantly lower than control mice.	Lycopene	194-202	glutamic pyruvic transaminase, soluble	Mus musculus	116-119
33987329-5	2021	Lycopene inhibited F4/80+ macrophage and Ly6G+ neutrophil accumulation, which further decreased the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin 6 (IL-6).	Lycopene	0-8	adhesion G protein-coupled receptor E1	Mus musculus	19-24
33987329-7	2021	In these KCs, lycopene-induced upregulation of autophagy inhibited NOD-like receptor family pyrin domain-containing 3 protein (NLRP3) inflammasome activation, which was demonstrated by the reduced mRNA and protein levels of NLRP3, cleaved caspase-1, an apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and IL-1beta.	Lycopene	14-22	NLR family, pyrin domain containing 3	Mus musculus	127-132
33987329-7	2021	In these KCs, lycopene-induced upregulation of autophagy inhibited NOD-like receptor family pyrin domain-containing 3 protein (NLRP3) inflammasome activation, which was demonstrated by the reduced mRNA and protein levels of NLRP3, cleaved caspase-1, an apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and IL-1beta.	Lycopene	14-22	NLR family, pyrin domain containing 3	Mus musculus	224-229
33987329-7	2021	In these KCs, lycopene-induced upregulation of autophagy inhibited NOD-like receptor family pyrin domain-containing 3 protein (NLRP3) inflammasome activation, which was demonstrated by the reduced mRNA and protein levels of NLRP3, cleaved caspase-1, an apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and IL-1beta.	Lycopene	14-22	caspase 1	Mus musculus	239-248
33987329-7	2021	In these KCs, lycopene-induced upregulation of autophagy inhibited NOD-like receptor family pyrin domain-containing 3 protein (NLRP3) inflammasome activation, which was demonstrated by the reduced mRNA and protein levels of NLRP3, cleaved caspase-1, an apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and IL-1beta.	Lycopene	14-22	interleukin 1 alpha	Mus musculus	344-352
33987329-8	2021	Furthermore, 3-methyladenine, an autophagy inhibitor, abolished lycopene"s inhibitory effect on the NLRP3 inflammasome in KCs, which led to increased hepatic IR injury.	Lycopene	64-72	NLR family, pyrin domain containing 3	Mus musculus	100-105
33987329-9	2021	Intriguingly, we identified that the protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) were elevated in KCs isolated from IR-stressed mice pretreated with lycopene.	Lycopene	202-210	nuclear factor, erythroid derived 2, like 2	Mus musculus	55-98
33987329-9	2021	Intriguingly, we identified that the protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) were elevated in KCs isolated from IR-stressed mice pretreated with lycopene.	Lycopene	202-210	nuclear factor, erythroid derived 2, like 2	Mus musculus	100-104
33987329-9	2021	Intriguingly, we identified that the protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) were elevated in KCs isolated from IR-stressed mice pretreated with lycopene.	Lycopene	202-210	heme oxygenase 1	Mus musculus	110-126
33987329-9	2021	Intriguingly, we identified that the protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) were elevated in KCs isolated from IR-stressed mice pretreated with lycopene.	Lycopene	202-210	heme oxygenase 1	Mus musculus	128-132
33987329-10	2021	Nrf2-siRNA or HO-1-siRNA could block the autophagy activation enhanced by lycopene in KCs, resulting in the activation of the NLRP3 inflammasome and aggravated hepatic IR injury.	Lycopene	74-82	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
33987329-10	2021	Nrf2-siRNA or HO-1-siRNA could block the autophagy activation enhanced by lycopene in KCs, resulting in the activation of the NLRP3 inflammasome and aggravated hepatic IR injury.	Lycopene	74-82	heme oxygenase 1	Mus musculus	14-18
33987329-10	2021	Nrf2-siRNA or HO-1-siRNA could block the autophagy activation enhanced by lycopene in KCs, resulting in the activation of the NLRP3 inflammasome and aggravated hepatic IR injury.	Lycopene	74-82	NLR family, pyrin domain containing 3	Mus musculus	126-131
33987329-11	2021	Conclusions: Our findings demonstrated that lycopene promoted Nrf2/HO-1 pathway activation and further suppressed the NLRP3 inflammasome via enhancing KC autophagy, which alleviated hepatic IR injury.	Lycopene	44-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	62-66
33987329-11	2021	Conclusions: Our findings demonstrated that lycopene promoted Nrf2/HO-1 pathway activation and further suppressed the NLRP3 inflammasome via enhancing KC autophagy, which alleviated hepatic IR injury.	Lycopene	44-52	heme oxygenase 1	Mus musculus	67-71
33987329-11	2021	Conclusions: Our findings demonstrated that lycopene promoted Nrf2/HO-1 pathway activation and further suppressed the NLRP3 inflammasome via enhancing KC autophagy, which alleviated hepatic IR injury.	Lycopene	44-52	NLR family, pyrin domain containing 3	Mus musculus	118-123
33668703-6	2021	The studies presented address tissue accumulation of lycopene, the modification of bioavailability due to genetic and dietary factors, and lycopene cleavage by the enzymes ss-carotene oxygenase 1 (BCO1) and ss-carotene oxygenase 2 (BCO2).	Lycopene	139-147	beta-carotene oxygenase 1	Homo sapiens	197-201
33987329-5	2021	Lycopene inhibited F4/80+ macrophage and Ly6G+ neutrophil accumulation, which further decreased the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin 6 (IL-6).	Lycopene	0-8	lymphocyte antigen 6 complex, locus G	Mus musculus	41-45
33987329-5	2021	Lycopene inhibited F4/80+ macrophage and Ly6G+ neutrophil accumulation, which further decreased the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin 6 (IL-6).	Lycopene	0-8	tumor necrosis factor	Mus musculus	110-137
33987329-5	2021	Lycopene inhibited F4/80+ macrophage and Ly6G+ neutrophil accumulation, which further decreased the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin 6 (IL-6).	Lycopene	0-8	tumor necrosis factor	Mus musculus	139-148
33987329-5	2021	Lycopene inhibited F4/80+ macrophage and Ly6G+ neutrophil accumulation, which further decreased the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and interleukin 6 (IL-6).	Lycopene	0-8	interleukin 1 beta	Mus musculus	151-168
33751809-0	2021	Lycopene inhibits IL-1beta-induced inflammation in mouse chondrocytes and mediates murine osteoarthritis.	Lycopene	0-8	interleukin 1 alpha	Mus musculus	18-26
33484250-2	2021	beta-carotene is generated from lycopene by the lycopene beta-cyclase (LCYB).	Lycopene	32-40	lycopene beta cyclase, chloroplastic	Nicotiana tabacum	71-75
33152222-8	2021	Lycopene increased the mRNA abundance of adenosine monophosphate activated protein kinase alpha (AMPK-alpha), whereas decreased the mRNA abundance of sterol regulatory element-binding protein 1, FAS and ACC compared to the control group (p<0.05).	Lycopene	0-8	sterol regulatory element binding transcription factor 1	Gallus gallus	150-193
33152222-8	2021	Lycopene increased the mRNA abundance of adenosine monophosphate activated protein kinase alpha (AMPK-alpha), whereas decreased the mRNA abundance of sterol regulatory element-binding protein 1, FAS and ACC compared to the control group (p<0.05).	Lycopene	0-8	fatty acid synthase	Gallus gallus	195-198
32718121-11	2021	Lycopene treatment significantly increased Bax expression (P < 0.0001) and decreased Bcl-2 expression (P < 0.0001) in HeLa cells.	Lycopene	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	43-46
32718121-11	2021	Lycopene treatment significantly increased Bax expression (P < 0.0001) and decreased Bcl-2 expression (P < 0.0001) in HeLa cells.	Lycopene	0-8	BCL2 apoptosis regulator	Homo sapiens	85-90
32718121-12	2021	Furthermore, lycopene markedly activated the Nrf2 expression (P < 0.001) and suppressed the NF-?B signaling pathway (P < 0.0001).	Lycopene	13-21	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
32718121-13	2021	CONCLUSION: Lycopene increases the sensitization of cervical cancer cells to cisplatin via inhibition of cell viability, up-regulation of Bax expression, and down-regulation of Bcl-2 expression.	Lycopene	12-20	BCL2 associated X, apoptosis regulator	Homo sapiens	138-141
32718121-13	2021	CONCLUSION: Lycopene increases the sensitization of cervical cancer cells to cisplatin via inhibition of cell viability, up-regulation of Bax expression, and down-regulation of Bcl-2 expression.	Lycopene	12-20	BCL2 apoptosis regulator	Homo sapiens	177-182
32718121-14	2021	Furthermore, anticancer effect of lycopene might be also associated with suppression of NF-?B-mediated inflammatory responses, and modulation of Nrf2-mediated oxidative stress.	Lycopene	34-42	NFE2 like bZIP transcription factor 2	Homo sapiens	145-149
33668703-7	2021	The current literature suggests that the majority of lycopene is cleaved eccentrically by BCO2, yet further research is needed to probe the enzymatic cleavage activity at the tissue level.	Lycopene	53-61	beta-carotene oxygenase 2	Homo sapiens	90-94
33672594-6	2021	This study aimed to investigate whether lycopene inhibits the EtOH/POA-induced increase in ROS production, zymogen activation, and expression of the inflammatory cytokine IL-6 in EtOH/POA-stimulated pancreatic acinar AR42J cells.	Lycopene	40-48	interleukin 6	Rattus norvegicus	171-175
33672594-7	2021	EtOH/POA increased the ROS levels, NADPH oxidase and NF-kappaB activities, zymogen activation, IL-6 expression, and mitochondrial dysfunction, which were inhibited by lycopene.	Lycopene	167-175	interleukin 6	Rattus norvegicus	95-99
33672594-9	2021	Therefore, lycopene inhibits EtOH/POA-induced mitochondrial dysfunction, zymogen activation, and IL-6 expression by suppressing NADPH oxidase-mediated ROS production in pancreatic acinar cells.	Lycopene	11-19	interleukin 6	Rattus norvegicus	97-101
33475360-0	2021	Lycopene Ameliorates Di(2-ethylhexyl) Phthalate-Induced Pyroptosis in Spleen via Suppression of Classic Caspase-1/NLRP3 Pathway.	Lycopene	0-8	caspase 1	Mus musculus	104-113
33546473-5	2021	In addition, Day-2 embryos and Day-6 blastocysts treated with 0.1 muM lycopene showed significantly reduced mRNA expression related to antioxidant enzymes (SOD1, SOD2, CATALASE) and apoptosis (BAX/BCL2L1 ratio).	Lycopene	70-78	superoxide dismutase 1	Sus scrofa	156-160
33546473-5	2021	In addition, Day-2 embryos and Day-6 blastocysts treated with 0.1 muM lycopene showed significantly reduced mRNA expression related to antioxidant enzymes (SOD1, SOD2, CATALASE) and apoptosis (BAX/BCL2L1 ratio).	Lycopene	70-78	superoxide dismutase 2	Sus scrofa	162-166
33546473-5	2021	In addition, Day-2 embryos and Day-6 blastocysts treated with 0.1 muM lycopene showed significantly reduced mRNA expression related to antioxidant enzymes (SOD1, SOD2, CATALASE) and apoptosis (BAX/BCL2L1 ratio).	Lycopene	70-78	catalase	Sus scrofa	168-176
33546473-5	2021	In addition, Day-2 embryos and Day-6 blastocysts treated with 0.1 muM lycopene showed significantly reduced mRNA expression related to antioxidant enzymes (SOD1, SOD2, CATALASE) and apoptosis (BAX/BCL2L1 ratio).	Lycopene	70-78	apoptosis regulator BAX	Sus scrofa	193-196
33546473-5	2021	In addition, Day-2 embryos and Day-6 blastocysts treated with 0.1 muM lycopene showed significantly reduced mRNA expression related to antioxidant enzymes (SOD1, SOD2, CATALASE) and apoptosis (BAX/BCL2L1 ratio).	Lycopene	70-78	BCL2 like 1	Sus scrofa	197-203
33672083-4	2021	Among landraces, P-44 in green fruits is highlighted for its content in carotenoids, chlorophylls, phenols, and ascorbic acid, and P-46 for its antioxidant capacity and lycopene content.	Lycopene	169-177	interferon induced protein 44	Homo sapiens	17-21
33672083-5	2021	Upon maturity, P-48, P-44, and P-41 presented higher levels of phenols and lycopene, and P-39 of phenols, carotenoid, and DPPH.	Lycopene	75-83	interferon regulatory factor 9	Homo sapiens	15-19
33672083-5	2021	Upon maturity, P-48, P-44, and P-41 presented higher levels of phenols and lycopene, and P-39 of phenols, carotenoid, and DPPH.	Lycopene	75-83	interferon induced protein 44	Homo sapiens	21-25
33672083-5	2021	Upon maturity, P-48, P-44, and P-41 presented higher levels of phenols and lycopene, and P-39 of phenols, carotenoid, and DPPH.	Lycopene	75-83	mitogen-activated protein kinase 1	Homo sapiens	31-35
33528746-2	2021	In the microalgal carotenoid biosynthetic pathway, lycopene is converted either into beta-carotene by lycopene beta-cyclase or into alpha-carotene by lycopene epsilon-cyclase (LCYE) and lycopene beta-cyclase.	Lycopene	51-59	uncharacterized protein	Chlamydomonas reinhardtii	150-174
33528746-2	2021	In the microalgal carotenoid biosynthetic pathway, lycopene is converted either into beta-carotene by lycopene beta-cyclase or into alpha-carotene by lycopene epsilon-cyclase (LCYE) and lycopene beta-cyclase.	Lycopene	51-59	uncharacterized protein	Chlamydomonas reinhardtii	176-180
33528746-3	2021	In this study, we overexpressed the LCYE gene in C. reinhardtii to estimate its effect on lycopene metabolism and lutein production.	Lycopene	90-98	uncharacterized protein	Chlamydomonas reinhardtii	36-40
33528746-6	2021	These results suggest that LCYE overexpression enhances the conversion of lycopene to alpha-carotene, which in turn improves lutein productivity.	Lycopene	74-82	uncharacterized protein	Chlamydomonas reinhardtii	27-31
33528746-8	2021	Considering that the inhibition of the lycopene cyclization steps often induces higher expression in genes upstream of metabolic branches, this result implies that the redirection from beta-carotene to alpha-carotene by LCYE overexpression might also enhance upstream gene expression, thereby leading to auxiliary beta-carotene production.	Lycopene	39-47	uncharacterized protein	Chlamydomonas reinhardtii	220-224
33475360-0	2021	Lycopene Ameliorates Di(2-ethylhexyl) Phthalate-Induced Pyroptosis in Spleen via Suppression of Classic Caspase-1/NLRP3 Pathway.	Lycopene	0-8	NLR family, pyrin domain containing 3	Mus musculus	114-119
33573002-6	2021	Dietary lycopene supplementation increased the activity of antioxidant enzymes (total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT)) (P < 0.05) and decreased the thiobarbituric acid reactive substance (TBARS) and carbonyl contents (P < 0.05).	Lycopene	8-16	catalase	Ovis aries	177-185
33385251-12	2021	Moreover, lycopene significantly reduced the level of iNOS, nNOS, and NO in the brain.	Lycopene	10-18	nitric oxide synthase 2	Rattus norvegicus	54-58
33385251-12	2021	Moreover, lycopene significantly reduced the level of iNOS, nNOS, and NO in the brain.	Lycopene	10-18	nitric oxide synthase 1	Rattus norvegicus	60-64
33183443-13	2021	The lycopene nanocarrier inhibits the proliferation of HepG2, HCCLM3 human liver cancer cells, induces apoptosis, regulates the oxidative stress response in the cell, and regulates the Nrf2/AREE antioxidant signaling pathway, thereby promoting tumor cell apoptosis.	Lycopene	4-12	NFE2 like bZIP transcription factor 2	Homo sapiens	185-189
33573002-6	2021	Dietary lycopene supplementation increased the activity of antioxidant enzymes (total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT)) (P < 0.05) and decreased the thiobarbituric acid reactive substance (TBARS) and carbonyl contents (P < 0.05).	Lycopene	8-16	catalase	Ovis aries	187-190
33531840-0	2021	Effect of Lycopene on Oral Squamous Cell Carcinoma Cell Growth by Inhibiting IGF1 Pathway.	Lycopene	10-18	insulin like growth factor 1	Homo sapiens	77-81
33531840-10	2021	And then, we investigated the changing of IGF1 signaling pathway, on the protein levels of tumor tissue after lycopene.	Lycopene	110-118	insulin like growth factor 1	Homo sapiens	42-46
33531840-14	2021	Mechanistically, ingenuity pathway analysis further revealed that IGF1 pathway participate in killing effects on OSCC after treatment of lycopene.	Lycopene	137-145	insulin like growth factor 1	Homo sapiens	66-70
33531840-15	2021	Lycopene may inhibit the pathway by regulating protein expression of IGF1, IGF binding protein (BP) 1, IGFBP3, transcription factor Jun/AP-1 (JUN), and forkhead box O1 (FOXO1).	Lycopene	0-8	insulin like growth factor 1	Homo sapiens	69-73
33531840-15	2021	Lycopene may inhibit the pathway by regulating protein expression of IGF1, IGF binding protein (BP) 1, IGFBP3, transcription factor Jun/AP-1 (JUN), and forkhead box O1 (FOXO1).	Lycopene	0-8	insulin like growth factor binding protein 3	Homo sapiens	103-109
33531840-15	2021	Lycopene may inhibit the pathway by regulating protein expression of IGF1, IGF binding protein (BP) 1, IGFBP3, transcription factor Jun/AP-1 (JUN), and forkhead box O1 (FOXO1).	Lycopene	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-140
33531840-15	2021	Lycopene may inhibit the pathway by regulating protein expression of IGF1, IGF binding protein (BP) 1, IGFBP3, transcription factor Jun/AP-1 (JUN), and forkhead box O1 (FOXO1).	Lycopene	0-8	forkhead box O1	Homo sapiens	152-167
33531840-15	2021	Lycopene may inhibit the pathway by regulating protein expression of IGF1, IGF binding protein (BP) 1, IGFBP3, transcription factor Jun/AP-1 (JUN), and forkhead box O1 (FOXO1).	Lycopene	0-8	forkhead box O1	Homo sapiens	169-174
33531840-16	2021	Conclusion: These observations indicate that lycopene regulates OSCC cell growth by inhibiting IGF1 pathway, which may be a promising agent for the treatment of OSCC.	Lycopene	45-53	insulin like growth factor 1	Homo sapiens	95-99
33220863-4	2020	During the preliminary screening, five positive Gal4 variants were isolated based on the lycopene-indicated high-throughput screening method.	Lycopene	89-97	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	48-52
33355018-1	2021	Several randomized controlled trials (RCTs) have investigated the effect of lycopene supplementation on serum levels of prostate-specific antigen (PSA) in patients with prostate cancer.	Lycopene	76-84	kallikrein related peptidase 3	Homo sapiens	120-145
33355018-1	2021	Several randomized controlled trials (RCTs) have investigated the effect of lycopene supplementation on serum levels of prostate-specific antigen (PSA) in patients with prostate cancer.	Lycopene	76-84	kallikrein related peptidase 3	Homo sapiens	147-150
33355018-3	2021	We systematically searched PubMed, Embase, and Scopus up to January 2020 to find RCTs investigating the effect of lycopene supplementation on serum levels of PSA in patients with non-metastatic prostate cancer.	Lycopene	114-122	kallikrein related peptidase 3	Homo sapiens	158-161
33355018-10	2021	Although lycopene supplementation did not produce any reduction in PSA levels overall, a significant reducing effect was observed in patients with higher levels of baseline PSA.	Lycopene	9-17	kallikrein related peptidase 3	Homo sapiens	173-176
32712090-3	2020	Compared with expression in the sham group, mTOR, pS6, p4EBP, GFAP, and Iba-1 decreased and SIRT1 increased in the lycopene group (P < 0.01).	Lycopene	115-123	mechanistic target of rapamycin kinase	Rattus norvegicus	44-48
32712090-3	2020	Compared with expression in the sham group, mTOR, pS6, p4EBP, GFAP, and Iba-1 decreased and SIRT1 increased in the lycopene group (P < 0.01).	Lycopene	115-123	glial fibrillary acidic protein	Rattus norvegicus	62-66
32712090-3	2020	Compared with expression in the sham group, mTOR, pS6, p4EBP, GFAP, and Iba-1 decreased and SIRT1 increased in the lycopene group (P < 0.01).	Lycopene	115-123	allograft inflammatory factor 1	Rattus norvegicus	72-77
32712090-3	2020	Compared with expression in the sham group, mTOR, pS6, p4EBP, GFAP, and Iba-1 decreased and SIRT1 increased in the lycopene group (P < 0.01).	Lycopene	115-123	sirtuin 1	Rattus norvegicus	92-97
33259908-0	2021	The effects of lycopene supplementation on serum insulin-like growth factor 1 (IGF-1) levels and cardiovascular disease: A dose-response meta-analysis of clinical trials.	Lycopene	15-23	insulin like growth factor 1	Homo sapiens	49-77
33259908-0	2021	The effects of lycopene supplementation on serum insulin-like growth factor 1 (IGF-1) levels and cardiovascular disease: A dose-response meta-analysis of clinical trials.	Lycopene	15-23	insulin like growth factor 1	Homo sapiens	79-84
33259908-1	2021	BACKGROUND: The results of human studies assessing the efficacy of lycopene on insulin-like growth factor 1 (IGF-1) levels are inconsistent.	Lycopene	67-75	insulin like growth factor 1	Homo sapiens	79-107
33259908-1	2021	BACKGROUND: The results of human studies assessing the efficacy of lycopene on insulin-like growth factor 1 (IGF-1) levels are inconsistent.	Lycopene	67-75	insulin like growth factor 1	Homo sapiens	109-114
33259908-2	2021	Thus, we performed a systematic review and meta-analysis to examine the effects of lycopene supplementation on serum IGF-1 levels and cardiovascular disease.	Lycopene	83-91	insulin like growth factor 1	Homo sapiens	117-122
33259908-5	2021	IGF-1 levels were non-significantly decreased in lycopene group compared to the control (WMD: -6.74 ng/ml, 95% CI: -23.01 to 9.52, p = 0.42; I2 = 94.3%).	Lycopene	49-57	insulin like growth factor 1	Homo sapiens	0-5
33259908-6	2021	Subgroup analysis revealed a significantly decrease in IGF-1 levels upon lycopene supplementation at doses >=15 mg/d (WMD: -6.40 ng/ml), intervention period <12 weeks (WMD: -6.49 ng/ml), and subjects aged >=60 years (WMD: -24.98 mg/dl).	Lycopene	73-81	insulin like growth factor 1	Homo sapiens	55-60
33259908-7	2021	In addition, lycopene intake significantly reduced IGF-1 levels upon healthy conditions (WMD: -25.59 ng/ml) when compared with cancer patients (WMD: 0.35 ng/ml).	Lycopene	13-21	insulin like growth factor 1	Homo sapiens	51-56
32712090-6	2020	Intrathecal injection of 3-MA (a mTOR agonist) or EX-527 (an inhibitor of Sirt1) partially antagonized lycopene-induced analgesia.	Lycopene	103-111	mechanistic target of rapamycin kinase	Rattus norvegicus	33-37
32712090-6	2020	Intrathecal injection of 3-MA (a mTOR agonist) or EX-527 (an inhibitor of Sirt1) partially antagonized lycopene-induced analgesia.	Lycopene	103-111	sirtuin 1	Rattus norvegicus	74-79
32712090-9	2020	The present data indicated that the SIRT1/mTOR pathway changed in the spinal dorsal horn of BIP rats; Lycopene alleviated the pain sensitization of BIP rats by regulating the SIRT1/mTOR pathway and glial activation in the spinal dorsal horn.	Lycopene	102-110	sirtuin 1	Rattus norvegicus	36-41
32712090-9	2020	The present data indicated that the SIRT1/mTOR pathway changed in the spinal dorsal horn of BIP rats; Lycopene alleviated the pain sensitization of BIP rats by regulating the SIRT1/mTOR pathway and glial activation in the spinal dorsal horn.	Lycopene	102-110	sirtuin 1	Rattus norvegicus	175-180
32712090-9	2020	The present data indicated that the SIRT1/mTOR pathway changed in the spinal dorsal horn of BIP rats; Lycopene alleviated the pain sensitization of BIP rats by regulating the SIRT1/mTOR pathway and glial activation in the spinal dorsal horn.	Lycopene	102-110	mechanistic target of rapamycin kinase	Rattus norvegicus	181-185
33097966-1	2020	Lycopene is a dark red carotenoid belonging to C40 terpenoids and is widely found in a variety of plants, especially ripe red fruits and vegetables.	Lycopene	0-8	CCR4-NOT transcription complex subunit 11	Homo sapiens	47-50
33220863-6	2020	Through combinatorial site-directed mutagenesis, the best variant Gal4T406A/V413A was obtained, which successfully increased the transcription of PGAL-driven lycopene pathway genes and led to 48 % higher lycopene accumulation relative to the wild-type Gal4.	Lycopene	158-166	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	66-70
33220863-6	2020	Through combinatorial site-directed mutagenesis, the best variant Gal4T406A/V413A was obtained, which successfully increased the transcription of PGAL-driven lycopene pathway genes and led to 48 % higher lycopene accumulation relative to the wild-type Gal4.	Lycopene	204-212	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	66-70
32592701-7	2020	Mechanistic studies revealed that lycopene treatment (20 mg/kg, 12 days) could suppress the SPS-induced increase in levels of interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha (TNF-alpha), and nitrite in the hippocampus and prefrontal cortex in mice, as well as the increased markers that indicate high levels of oxido-nitrosative stress in the hippocampus and prefrontal cortex in SPS mice.	Lycopene	34-42	interleukin 6	Mus musculus	126-139
33166770-3	2020	Previous studies showed that SlSGR1 functioned in chl degradation and lycopene accumulation during fruit ripening of tomato (Solanum lycopersicum).	Lycopene	70-78	senescence-inducible chloroplast stay-green protein 1	Solanum lycopersicum	29-35
33390957-0	2020	Lycopene Exerts Neuroprotective Effects After Hypoxic-Ischemic Brain Injury in Neonatal Rats via the Nuclear Factor Erythroid-2 Related Factor 2/Nuclear Factor-kappa-Gene Binding Pathway.	Lycopene	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	101-144
33238590-1	2020	The bone protective effects of carotenoids have been demonstrated in several studies, and the inhibition of RANKL-induced osteoclast differentiation by lycopene has also been demonstrated.	Lycopene	152-160	TNF superfamily member 11	Homo sapiens	108-113
32810585-0	2020	Lycopene ameliorates chronic stress-induced hippocampal injury and subsequent learning and memory dysfunction through inhibiting ROS/JNK signaling pathway in rats.	Lycopene	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	133-136
32885410-5	2020	Lycopene also ameliorated H2 O2 -induced damage and reduced the expression of apoptotic markers, such as Bcl-2, Bax, and cleaved caspase 3.	Lycopene	0-8	BCL2 apoptosis regulator	Homo sapiens	105-110
32885410-5	2020	Lycopene also ameliorated H2 O2 -induced damage and reduced the expression of apoptotic markers, such as Bcl-2, Bax, and cleaved caspase 3.	Lycopene	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	112-115
32885410-7	2020	Exogenous H2 O2 activated the GRP78/PERK/eIF2alpha signaling pathway, which was inhibited by pretreatment with lycopene.	Lycopene	111-119	heat shock protein family A (Hsp70) member 5	Homo sapiens	30-35
32885410-7	2020	Exogenous H2 O2 activated the GRP78/PERK/eIF2alpha signaling pathway, which was inhibited by pretreatment with lycopene.	Lycopene	111-119	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	36-40
32885410-7	2020	Exogenous H2 O2 activated the GRP78/PERK/eIF2alpha signaling pathway, which was inhibited by pretreatment with lycopene.	Lycopene	111-119	eukaryotic translation initiation factor 2A	Homo sapiens	41-50
32885410-8	2020	Finally, lycopene significantly ameliorated ER stress-induced activation and nuclear translocation of CHOP.	Lycopene	9-17	DNA damage inducible transcript 3	Homo sapiens	102-106
32885410-9	2020	Overexpression of CHOP markedly reversed the antiapoptotic effects of lycopene, indicating that it is essential for the latter"s protective effects.	Lycopene	70-78	DNA damage inducible transcript 3	Homo sapiens	18-22
32885410-10	2020	Taken together, lycopene protects neuroblastoma cells from oxidative stress and ER stress-induced damage by inhibiting the PERK-CHOP signaling pathway, which is a potential therapeutic target in neurodegenerative diseases.	Lycopene	16-24	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	123-127
32885410-10	2020	Taken together, lycopene protects neuroblastoma cells from oxidative stress and ER stress-induced damage by inhibiting the PERK-CHOP signaling pathway, which is a potential therapeutic target in neurodegenerative diseases.	Lycopene	16-24	DNA damage inducible transcript 3	Homo sapiens	128-132
33222104-6	2020	Molecular dynamics (MD) simulation revealed lycopene molecule was wrapped within the aggregates of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and PEG 6000 through extensive hydrogen bond interactions, which was experimentally validated by DSC, XRD, and FTIR spectrum analysis.	Lycopene	44-52	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	135-142
32962341-0	2020	Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1alpha-Induced PPARalpha/PPARgamma/FXR/LXR System.	Lycopene	0-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-91
32962341-0	2020	Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1alpha-Induced PPARalpha/PPARgamma/FXR/LXR System.	Lycopene	0-8	peroxisome proliferator activated receptor alpha	Homo sapiens	100-109
32962341-0	2020	Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1alpha-Induced PPARalpha/PPARgamma/FXR/LXR System.	Lycopene	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	110-119
32962341-0	2020	Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1alpha-Induced PPARalpha/PPARgamma/FXR/LXR System.	Lycopene	0-8	nuclear receptor subfamily 1 group H member 4	Homo sapiens	120-123
32592701-7	2020	Mechanistic studies revealed that lycopene treatment (20 mg/kg, 12 days) could suppress the SPS-induced increase in levels of interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha (TNF-alpha), and nitrite in the hippocampus and prefrontal cortex in mice, as well as the increased markers that indicate high levels of oxido-nitrosative stress in the hippocampus and prefrontal cortex in SPS mice.	Lycopene	34-42	interleukin 6	Mus musculus	141-145
32592701-7	2020	Mechanistic studies revealed that lycopene treatment (20 mg/kg, 12 days) could suppress the SPS-induced increase in levels of interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha (TNF-alpha), and nitrite in the hippocampus and prefrontal cortex in mice, as well as the increased markers that indicate high levels of oxido-nitrosative stress in the hippocampus and prefrontal cortex in SPS mice.	Lycopene	34-42	interleukin 1 alpha	Mus musculus	148-156
32592701-7	2020	Mechanistic studies revealed that lycopene treatment (20 mg/kg, 12 days) could suppress the SPS-induced increase in levels of interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha (TNF-alpha), and nitrite in the hippocampus and prefrontal cortex in mice, as well as the increased markers that indicate high levels of oxido-nitrosative stress in the hippocampus and prefrontal cortex in SPS mice.	Lycopene	34-42	tumor necrosis factor	Mus musculus	158-185
32592701-7	2020	Mechanistic studies revealed that lycopene treatment (20 mg/kg, 12 days) could suppress the SPS-induced increase in levels of interleukin-6 (IL-6), IL-1beta, tumor necrosis factor-alpha (TNF-alpha), and nitrite in the hippocampus and prefrontal cortex in mice, as well as the increased markers that indicate high levels of oxido-nitrosative stress in the hippocampus and prefrontal cortex in SPS mice.	Lycopene	34-42	tumor necrosis factor	Mus musculus	187-196
32592701-8	2020	Lycopene treatment (20 mg/kg, 12 days) also suppressed the SPS-induced decrease in brain derived neurotrophic factor (BDNF) levels in the hippocampus and prefrontal cortex in mice.	Lycopene	0-8	brain derived neurotrophic factor	Mus musculus	83-116
32592701-8	2020	Lycopene treatment (20 mg/kg, 12 days) also suppressed the SPS-induced decrease in brain derived neurotrophic factor (BDNF) levels in the hippocampus and prefrontal cortex in mice.	Lycopene	0-8	brain derived neurotrophic factor	Mus musculus	118-122
32574665-0	2020	Combination of luteolin and lycopene effectively protect against the "two-hit" in NAFLD through Sirt1/AMPK signal pathway.	Lycopene	28-36	sirtuin 1	Homo sapiens	96-101
32982345-8	2020	Results: The combination of lycopene with metformin maintained the beneficial effects of the isolated treatments, improving the glucose tolerance and lipid profile, lessening biomarkers of oxidative damage, and increasing the paraoxonase 1 activity.	Lycopene	28-36	paraoxonase 1	Rattus norvegicus	226-239
32765784-0	2020	Lycopene attenuates high glucose-mediated apoptosis in MPC5 podocytes by promoting autophagy via the PI3K/AKT signaling pathway.	Lycopene	0-8	AKT serine/threonine kinase 1	Homo sapiens	106-109
33376684-10	2020	Serum levels of NGAL, KIM-1, and MDA were reduced significantly in the LPN group as compared with AKI (P = 0.001), while the SOD serum level was increased to 33.	Lycopene	71-74	lipocalin 2	Rattus norvegicus	16-20
33376684-10	2020	Serum levels of NGAL, KIM-1, and MDA were reduced significantly in the LPN group as compared with AKI (P = 0.001), while the SOD serum level was increased to 33.	Lycopene	71-74	hepatitis A virus cellular receptor 1	Rattus norvegicus	22-27
32995076-10	2020	Mature-green fruits also displayed a salt-dependent higher induction in the expression of PSY1, PDS, ZDS, and LYCB, key genes of the carotenoid biosynthesis pathway, in correlation with increased lycopene, lutein, beta-carotene, and violaxanthin levels.	Lycopene	196-204	phytoene synthase 1, chloroplastic	Solanum lycopersicum	90-94
32574665-0	2020	Combination of luteolin and lycopene effectively protect against the "two-hit" in NAFLD through Sirt1/AMPK signal pathway.	Lycopene	28-36	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	102-106
32574665-8	2020	SIGNIFICANCE: Thus, luteolin and lycopene in combination can effectively ameliorate "two-hit" in NAFLD through activation of the Sirt1/AMPK pathway.	Lycopene	33-41	sirtuin 1	Homo sapiens	129-134
32574665-8	2020	SIGNIFICANCE: Thus, luteolin and lycopene in combination can effectively ameliorate "two-hit" in NAFLD through activation of the Sirt1/AMPK pathway.	Lycopene	33-41	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	135-139
32553810-5	2020	Furthermore, through western blotting analysis lycopene intervention was found to have significantly improved apoptosis cytokines by increasing the protein expression levels of PPARgamma and caspase-3, and also significantly reduced inflammatory cytokines by decreasing the protein expression of NF-kappaB and COX-2 in the esophagus tissue, especially in the 25 mg/kg of lycopene intervention group (all P < 0.05).	Lycopene	47-55	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	177-186
32544411-0	2020	Lycopene protects against central and peripheral neuropathy by inhibiting Oxaliplatin-induced ATF-6 pathway, apoptosis, inflammation and oxidative stress in brains and sciatic tissues of rats.	Lycopene	0-8	activating transcription factor 6	Rattus norvegicus	94-99
32553810-5	2020	Furthermore, through western blotting analysis lycopene intervention was found to have significantly improved apoptosis cytokines by increasing the protein expression levels of PPARgamma and caspase-3, and also significantly reduced inflammatory cytokines by decreasing the protein expression of NF-kappaB and COX-2 in the esophagus tissue, especially in the 25 mg/kg of lycopene intervention group (all P < 0.05).	Lycopene	47-55	caspase 3	Rattus norvegicus	191-200
32553810-5	2020	Furthermore, through western blotting analysis lycopene intervention was found to have significantly improved apoptosis cytokines by increasing the protein expression levels of PPARgamma and caspase-3, and also significantly reduced inflammatory cytokines by decreasing the protein expression of NF-kappaB and COX-2 in the esophagus tissue, especially in the 25 mg/kg of lycopene intervention group (all P < 0.05).	Lycopene	47-55	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	310-315
32153214-7	2020	Mechanistically, lycopene upregulated the protein expression of tyrosine receptor kinase B, which resulted in an upsurge in its downstream cascades MAPK/ERK1/2/cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway in the hippocampus of BPA-intoxicated rats.	Lycopene	17-25	mitogen activated protein kinase 3	Rattus norvegicus	153-159
32153214-7	2020	Mechanistically, lycopene upregulated the protein expression of tyrosine receptor kinase B, which resulted in an upsurge in its downstream cascades MAPK/ERK1/2/cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway in the hippocampus of BPA-intoxicated rats.	Lycopene	17-25	cAMP responsive element binding protein 1	Rattus norvegicus	199-203
32153214-7	2020	Mechanistically, lycopene upregulated the protein expression of tyrosine receptor kinase B, which resulted in an upsurge in its downstream cascades MAPK/ERK1/2/cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway in the hippocampus of BPA-intoxicated rats.	Lycopene	17-25	brain-derived neurotrophic factor	Rattus norvegicus	205-238
32153214-7	2020	Mechanistically, lycopene upregulated the protein expression of tyrosine receptor kinase B, which resulted in an upsurge in its downstream cascades MAPK/ERK1/2/cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway in the hippocampus of BPA-intoxicated rats.	Lycopene	17-25	brain-derived neurotrophic factor	Rattus norvegicus	240-244
32153214-8	2020	Furthermore, concurrent treatment of lycopene with BPA prevented apoptosis by marked decrease in Bcl-2 associated X protein (Bax) gene expression and caspase 3 activity while restoring B-cell leukemia/lymphoma-2 (Bcl-2) gene expression.	Lycopene	37-45	BCL2 associated X, apoptosis regulator	Rattus norvegicus	125-128
32153214-8	2020	Furthermore, concurrent treatment of lycopene with BPA prevented apoptosis by marked decrease in Bcl-2 associated X protein (Bax) gene expression and caspase 3 activity while restoring B-cell leukemia/lymphoma-2 (Bcl-2) gene expression.	Lycopene	37-45	caspase 3	Rattus norvegicus	150-159
32153214-8	2020	Furthermore, concurrent treatment of lycopene with BPA prevented apoptosis by marked decrease in Bcl-2 associated X protein (Bax) gene expression and caspase 3 activity while restoring B-cell leukemia/lymphoma-2 (Bcl-2) gene expression.	Lycopene	37-45	BCL2, apoptosis regulator	Rattus norvegicus	185-211
32153214-8	2020	Furthermore, concurrent treatment of lycopene with BPA prevented apoptosis by marked decrease in Bcl-2 associated X protein (Bax) gene expression and caspase 3 activity while restoring B-cell leukemia/lymphoma-2 (Bcl-2) gene expression.	Lycopene	37-45	BCL2, apoptosis regulator	Rattus norvegicus	97-102
32153214-9	2020	In conclusion, the present study provided evidence that lycopene exerted a neuroprotective effect against BPA intoxication in hippocampi of rats via its antioxidant properties, activation of MAPK/ERK pathway, and inhibiting a neuronal apoptosis which reflected on improving the learning and cognition memory.	Lycopene	56-64	mitogen activated protein kinase 3	Rattus norvegicus	196-199
32748591-5	2020	The results showed that when GPDpr and TEF1pr were used as promoters of crtE, crtB and crtI in lycopene synthesis pathway, the production of lycopene was 15.31 mg/L after 60 h fermentation in shaking flask.	Lycopene	95-103	translation elongation factor EF-1 alpha	Saccharomyces cerevisiae S288C	39-43
32813603-0	2020	Lycopene Alleviates Hepatic Hypoxia/Reoxygenation Injury Through Nrf2/HO-1 Pathway in AML12 Cell.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	65-69
32813603-0	2020	Lycopene Alleviates Hepatic Hypoxia/Reoxygenation Injury Through Nrf2/HO-1 Pathway in AML12 Cell.	Lycopene	0-8	heme oxygenase 1	Mus musculus	70-74
32813603-11	2020	Lycopene led to a reversed effect, with promotion on Nrf2 transfer from cytoplasm into nucleus and Nrf2/HO-1 pathway activation.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	53-57
32813603-11	2020	Lycopene led to a reversed effect, with promotion on Nrf2 transfer from cytoplasm into nucleus and Nrf2/HO-1 pathway activation.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	99-103
32813603-11	2020	Lycopene led to a reversed effect, with promotion on Nrf2 transfer from cytoplasm into nucleus and Nrf2/HO-1 pathway activation.	Lycopene	0-8	heme oxygenase 1	Mus musculus	104-108
32813603-13	2020	Lycopene could activate Nrf2/HO-1 pathway to protect hepatic cells against H/R injury.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	24-28
32813603-13	2020	Lycopene could activate Nrf2/HO-1 pathway to protect hepatic cells against H/R injury.	Lycopene	0-8	heme oxygenase 1	Mus musculus	29-33
32748591-5	2020	The results showed that when GPDpr and TEF1pr were used as promoters of crtE, crtB and crtI in lycopene synthesis pathway, the production of lycopene was 15.31 mg/L after 60 h fermentation in shaking flask.	Lycopene	141-149	translation elongation factor EF-1 alpha	Saccharomyces cerevisiae S288C	39-43
32659890-0	2020	Lycopene Inhibit IMQ-Induced Psoriasis-Like Inflammation by Inhibiting ICAM-1 Production in Mice.	Lycopene	0-8	intercellular adhesion molecule 1	Mus musculus	71-77
32708354-6	2020	In the cells exposed to smoke, lycopene increased 8-oxoguanine DNA glycosylase (OGG1) expression at 1 nM, 10 nM, 100 nM, and 1 muM (p < 0.05), but not at 10 muM.	Lycopene	31-39	8-oxoguanine DNA glycosylase	Homo sapiens	50-78
32708354-6	2020	In the cells exposed to smoke, lycopene increased 8-oxoguanine DNA glycosylase (OGG1) expression at 1 nM, 10 nM, 100 nM, and 1 muM (p < 0.05), but not at 10 muM.	Lycopene	31-39	8-oxoguanine DNA glycosylase	Homo sapiens	80-84
32708354-7	2020	Lycopene at lower doses also improved Nei like DNA glycosylases (NEIL1, NEIL2, NEIL3), and connexin-43 (Cx43) protein levels (p < 0.05).	Lycopene	0-8	nei like DNA glycosylase 1	Homo sapiens	65-70
32708354-7	2020	Lycopene at lower doses also improved Nei like DNA glycosylases (NEIL1, NEIL2, NEIL3), and connexin-43 (Cx43) protein levels (p < 0.05).	Lycopene	0-8	nei like DNA glycosylase 2	Homo sapiens	72-77
32708354-7	2020	Lycopene at lower doses also improved Nei like DNA glycosylases (NEIL1, NEIL2, NEIL3), and connexin-43 (Cx43) protein levels (p < 0.05).	Lycopene	0-8	nei like DNA glycosylase 3	Homo sapiens	79-84
32708354-7	2020	Lycopene at lower doses also improved Nei like DNA glycosylases (NEIL1, NEIL2, NEIL3), and connexin-43 (Cx43) protein levels (p < 0.05).	Lycopene	0-8	gap junction protein alpha 1	Homo sapiens	91-102
32708354-7	2020	Lycopene at lower doses also improved Nei like DNA glycosylases (NEIL1, NEIL2, NEIL3), and connexin-43 (Cx43) protein levels (p < 0.05).	Lycopene	0-8	gap junction protein alpha 1	Homo sapiens	104-108
32708354-8	2020	Interestingly, lycopene at lower concentrations promoted OGG1 expression within the cells exposed to smoke to an even greater extent than the cells not exposed to smoke (p < 0.01).	Lycopene	15-23	8-oxoguanine DNA glycosylase	Homo sapiens	57-61
32659890-6	2020	Therefore, it will be interesting to investigate the factors that contribute to the lycopene-mediated inhibition of ICAM-1 expression in psoriasis.	Lycopene	84-92	intercellular adhesion molecule 1	Mus musculus	116-122
32253029-0	2020	Effects of lycopene on vascular remodeling through the LXR-PI3K-AKT signaling pathway in APP/PS1 mice.	Lycopene	11-19	nuclear receptor subfamily 1, group H, member 3	Mus musculus	55-58
32606612-0	2020	Lycopene Inhibits Epithelial-Mesenchymal Transition and Promotes Apoptosis in Oral Cancer via PI3K/AKT/m-TOR Signal Pathway.	Lycopene	0-8	AKT serine/threonine kinase 1	Homo sapiens	99-102
32606612-0	2020	Lycopene Inhibits Epithelial-Mesenchymal Transition and Promotes Apoptosis in Oral Cancer via PI3K/AKT/m-TOR Signal Pathway.	Lycopene	0-8	RAR related orphan receptor C	Homo sapiens	105-108
32409479-6	2020	Furthermore, by assessing a triple phyAB1B2 mutant and fruit-specific PHYA- or PHYB2-silenced plants, we demonstrated that biosynthesis of the major tomato fruit carotenoid, lycopene, is sensitive to fruit-localized PHY-dependent temperature perception.	Lycopene	174-182	phytochrome B2	Solanum lycopersicum	79-84
32253029-0	2020	Effects of lycopene on vascular remodeling through the LXR-PI3K-AKT signaling pathway in APP/PS1 mice.	Lycopene	11-19	thymoma viral proto-oncogene 1	Mus musculus	64-67
32365333-0	2020	Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	84-88
32476138-4	2020	Moreover, the messenger RNA (mRNA) and protein expressions of NAD(P)H quinone reductase (NQO1) and heme oxygenase (HO-1) of the nuclear factor erythrocyte 2-related factor 2 (Nrf2) signaling pathway were significantly induced in petunidin, lycopene, and synergistic combinations, suggesting that the antioxidant action was through activating the Nrf2 antioxidant response pathway.	Lycopene	240-248	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	89-93
32476138-4	2020	Moreover, the messenger RNA (mRNA) and protein expressions of NAD(P)H quinone reductase (NQO1) and heme oxygenase (HO-1) of the nuclear factor erythrocyte 2-related factor 2 (Nrf2) signaling pathway were significantly induced in petunidin, lycopene, and synergistic combinations, suggesting that the antioxidant action was through activating the Nrf2 antioxidant response pathway.	Lycopene	240-248	heme oxygenase 1	Rattus norvegicus	115-119
32476138-4	2020	Moreover, the messenger RNA (mRNA) and protein expressions of NAD(P)H quinone reductase (NQO1) and heme oxygenase (HO-1) of the nuclear factor erythrocyte 2-related factor 2 (Nrf2) signaling pathway were significantly induced in petunidin, lycopene, and synergistic combinations, suggesting that the antioxidant action was through activating the Nrf2 antioxidant response pathway.	Lycopene	240-248	NFE2 like bZIP transcription factor 2	Rattus norvegicus	128-173
32476138-4	2020	Moreover, the messenger RNA (mRNA) and protein expressions of NAD(P)H quinone reductase (NQO1) and heme oxygenase (HO-1) of the nuclear factor erythrocyte 2-related factor 2 (Nrf2) signaling pathway were significantly induced in petunidin, lycopene, and synergistic combinations, suggesting that the antioxidant action was through activating the Nrf2 antioxidant response pathway.	Lycopene	240-248	NFE2 like bZIP transcription factor 2	Rattus norvegicus	175-179
32476138-4	2020	Moreover, the messenger RNA (mRNA) and protein expressions of NAD(P)H quinone reductase (NQO1) and heme oxygenase (HO-1) of the nuclear factor erythrocyte 2-related factor 2 (Nrf2) signaling pathway were significantly induced in petunidin, lycopene, and synergistic combinations, suggesting that the antioxidant action was through activating the Nrf2 antioxidant response pathway.	Lycopene	240-248	NFE2 like bZIP transcription factor 2	Rattus norvegicus	346-350
32151764-5	2020	We further found that lycopene was protective in NP tissue under oxidative stress and alleviated oxidative stress-induced apoptosis of degenerative human NPCs via Nrf2.	Lycopene	22-30	NFE2 like bZIP transcription factor 2	Homo sapiens	163-167
32151764-7	2020	In conclusion, our findings suggested that lycopene may alleviate disc degeneration under oxidative stress through the Nrf2 signaling pathway.	Lycopene	43-51	NFE2 like bZIP transcription factor 2	Homo sapiens	119-123
32466161-11	2020	Treatment with lycopene significantly increased testosterone levels, testes weight, and Bcl-2 mRNA expression, improved tubular structure and decreased malondialdehyde levels, BAX mRNA expression and TUNEL-positive cells.	Lycopene	15-23	BCL2, apoptosis regulator	Rattus norvegicus	88-93
32466161-11	2020	Treatment with lycopene significantly increased testosterone levels, testes weight, and Bcl-2 mRNA expression, improved tubular structure and decreased malondialdehyde levels, BAX mRNA expression and TUNEL-positive cells.	Lycopene	15-23	BCL2 associated X, apoptosis regulator	Rattus norvegicus	176-179
32365333-0	2020	Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation.	Lycopene	0-8	nucleoporin 62	Mus musculus	105-108
32365333-0	2020	Lycopene prevents carcinogen-induced cutaneous tumor by enhancing activation of the Nrf2 pathway through p62-triggered autophagic Keap1 degradation.	Lycopene	0-8	kelch-like ECH-associated protein 1	Mus musculus	130-135
32365333-6	2020	Lycopene stimulated the activation of antioxidant enzymes and the translocation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) that predominantly maintained intracellular redox equilibrium.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	108-112
32365333-6	2020	Lycopene stimulated the activation of antioxidant enzymes and the translocation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) that predominantly maintained intracellular redox equilibrium.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-157
32365333-8	2020	Further, lycopene enhanced the expression of autophagy protein p62.	Lycopene	9-17	nucleoporin 62	Mus musculus	63-66
32365333-10	2020	In conclusion, our study provides preclinical evidence of the chemopreventive effects of lycopene on cutaneous tumors and reveals the mechanistic link between lycopene"s stimulation of Nrf2 signaling pathway and p62-mediated degradation of Keap1 via the autophagy-lysosomal pathway.	Lycopene	159-167	nuclear factor, erythroid derived 2, like 2	Mus musculus	185-189
32365333-10	2020	In conclusion, our study provides preclinical evidence of the chemopreventive effects of lycopene on cutaneous tumors and reveals the mechanistic link between lycopene"s stimulation of Nrf2 signaling pathway and p62-mediated degradation of Keap1 via the autophagy-lysosomal pathway.	Lycopene	159-167	nucleoporin 62	Mus musculus	212-215
32365333-10	2020	In conclusion, our study provides preclinical evidence of the chemopreventive effects of lycopene on cutaneous tumors and reveals the mechanistic link between lycopene"s stimulation of Nrf2 signaling pathway and p62-mediated degradation of Keap1 via the autophagy-lysosomal pathway.	Lycopene	159-167	kelch-like ECH-associated protein 1	Mus musculus	240-245
32170789-5	2020	The genes involved in fat metabolism were analysed, and we found that lycopene significantly increased the expression of PGC1alpha, PPARalpha, RXRalpha and RARalpha in the liver, PPARgamma, RXRalpha and RXRgamma in the jejunum, and RARalpha in the duodenum (p < .05); reduced the expression of FABP1 and FABP10 in the liver, and FATP4 in the jejunum (p < .05).	Lycopene	70-78	peroxisome proliferator activated receptor alpha	Gallus gallus	132-141
32170789-5	2020	The genes involved in fat metabolism were analysed, and we found that lycopene significantly increased the expression of PGC1alpha, PPARalpha, RXRalpha and RARalpha in the liver, PPARgamma, RXRalpha and RXRgamma in the jejunum, and RARalpha in the duodenum (p < .05); reduced the expression of FABP1 and FABP10 in the liver, and FATP4 in the jejunum (p < .05).	Lycopene	70-78	retinoid X receptor alpha	Gallus gallus	143-151
32170789-5	2020	The genes involved in fat metabolism were analysed, and we found that lycopene significantly increased the expression of PGC1alpha, PPARalpha, RXRalpha and RARalpha in the liver, PPARgamma, RXRalpha and RXRgamma in the jejunum, and RARalpha in the duodenum (p < .05); reduced the expression of FABP1 and FABP10 in the liver, and FATP4 in the jejunum (p < .05).	Lycopene	70-78	retinoic acid receptor alpha	Gallus gallus	156-164
32170789-5	2020	The genes involved in fat metabolism were analysed, and we found that lycopene significantly increased the expression of PGC1alpha, PPARalpha, RXRalpha and RARalpha in the liver, PPARgamma, RXRalpha and RXRgamma in the jejunum, and RARalpha in the duodenum (p < .05); reduced the expression of FABP1 and FABP10 in the liver, and FATP4 in the jejunum (p < .05).	Lycopene	70-78	peroxisome proliferator-activated receptor gamma	Gallus gallus	179-188
32170789-5	2020	The genes involved in fat metabolism were analysed, and we found that lycopene significantly increased the expression of PGC1alpha, PPARalpha, RXRalpha and RARalpha in the liver, PPARgamma, RXRalpha and RXRgamma in the jejunum, and RARalpha in the duodenum (p < .05); reduced the expression of FABP1 and FABP10 in the liver, and FATP4 in the jejunum (p < .05).	Lycopene	70-78	retinoid X receptor alpha	Gallus gallus	190-198
32170789-5	2020	The genes involved in fat metabolism were analysed, and we found that lycopene significantly increased the expression of PGC1alpha, PPARalpha, RXRalpha and RARalpha in the liver, PPARgamma, RXRalpha and RXRgamma in the jejunum, and RARalpha in the duodenum (p < .05); reduced the expression of FABP1 and FABP10 in the liver, and FATP4 in the jejunum (p < .05).	Lycopene	70-78	retinoic acid receptor alpha	Gallus gallus	232-240
32170789-5	2020	The genes involved in fat metabolism were analysed, and we found that lycopene significantly increased the expression of PGC1alpha, PPARalpha, RXRalpha and RARalpha in the liver, PPARgamma, RXRalpha and RXRgamma in the jejunum, and RARalpha in the duodenum (p < .05); reduced the expression of FABP1 and FABP10 in the liver, and FATP4 in the jejunum (p < .05).	Lycopene	70-78	fatty acid binding protein 1	Gallus gallus	294-299
32170789-5	2020	The genes involved in fat metabolism were analysed, and we found that lycopene significantly increased the expression of PGC1alpha, PPARalpha, RXRalpha and RARalpha in the liver, PPARgamma, RXRalpha and RXRgamma in the jejunum, and RARalpha in the duodenum (p < .05); reduced the expression of FABP1 and FABP10 in the liver, and FATP4 in the jejunum (p < .05).	Lycopene	70-78	liver basic fatty acid binding protein	Gallus gallus	304-310
32170789-5	2020	The genes involved in fat metabolism were analysed, and we found that lycopene significantly increased the expression of PGC1alpha, PPARalpha, RXRalpha and RARalpha in the liver, PPARgamma, RXRalpha and RXRgamma in the jejunum, and RARalpha in the duodenum (p < .05); reduced the expression of FABP1 and FABP10 in the liver, and FATP4 in the jejunum (p < .05).	Lycopene	70-78	solute carrier family 27 member 4	Gallus gallus	329-334
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Lycopene	79-87	C-C motif chemokine ligand 2	Homo sapiens	146-151
32126272-3	2020	Owing to its potent antioxidant properties, lycopene can potentially alleviate enhanced levels of proinflammatory mediators (e.g., proinflammatory cytokines IL-8, -6, and -1, and oxidized phospholipids) and prevent NF-kappaB activation by modulating oxidative stress.	Lycopene	44-52	C-X-C motif chemokine ligand 8	Homo sapiens	157-173
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Lycopene	79-87	colony stimulating factor 1	Homo sapiens	153-158
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Lycopene	79-87	C-X-C motif chemokine ligand 10	Homo sapiens	164-171
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Lycopene	79-87	tumor necrosis factor	Homo sapiens	199-208
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Lycopene	79-87	interleukin 1 alpha	Homo sapiens	213-221
32410856-6	2020	In ECs and monocytes, three carotenoids, i.e., beta-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-alpha and IL-1beta, with CXCL-10 being the most repressed inflammatory mediator.	Lycopene	79-87	C-X-C motif chemokine ligand 10	Homo sapiens	228-235
32410856-7	2020	beta-Cryptoxanthin, lutein, and lycopene dramatically downregulated the fructose-induced CXCL-10 expression in vascular cells.	Lycopene	32-40	C-X-C motif chemokine ligand 10	Homo sapiens	89-96
32328606-3	2020	The results exhibited that lycopene did not affect cell growth, cell apoptosis, cell cycle, ROS and ATP levels of alpha cells, while it promoted the growth of beta cells, increased the ratio of S phase, reduced the ROS levels and increased the ATP levels of beta cells.	Lycopene	27-35	ATPase phospholipid transporting 8A2	Homo sapiens	244-247
32328606-4	2020	At the same time, lycopene treatment elevated the mRNA expression levels of tnfalpha, tgfbeta and hif1alpha in beta cells.	Lycopene	18-26	tumor necrosis factor	Homo sapiens	76-84
32328606-4	2020	At the same time, lycopene treatment elevated the mRNA expression levels of tnfalpha, tgfbeta and hif1alpha in beta cells.	Lycopene	18-26	transforming growth factor alpha	Homo sapiens	86-93
32328606-4	2020	At the same time, lycopene treatment elevated the mRNA expression levels of tnfalpha, tgfbeta and hif1alpha in beta cells.	Lycopene	18-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	98-107
31978713-0	2020	Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor gamma in high-fat diet-induced obese mice.	Lycopene	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	85-133
32368526-6	2020	Lycopene has its protective effect, which affects multiple IGF-1-activated signaling pathways.	Lycopene	0-8	insulin like growth factor 1	Homo sapiens	59-64
32368526-7	2020	Lycopene stimulates apoptosis through intrinsic pathways, by stimulating the pro-apoptotic factor of the mitochondrial cavity such as the Bax/Bak protein (an apoptotic promotor).	Lycopene	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	138-141
32368526-7	2020	Lycopene stimulates apoptosis through intrinsic pathways, by stimulating the pro-apoptotic factor of the mitochondrial cavity such as the Bax/Bak protein (an apoptotic promotor).	Lycopene	0-8	BCL2 antagonist/killer 1	Homo sapiens	142-145
32368526-9	2020	Hence, this study is conducted to measure the influence of lycopene on the level of IGF-1 in Indonesian human prostate cancer cells.	Lycopene	59-67	insulin like growth factor 1	Homo sapiens	84-89
32368526-14	2020	Results: The result showed that there was a significant difference in mean IGF-1 levels in the provision of various concentrations of lycopene and time of observation (p<0.05).	Lycopene	134-142	insulin like growth factor 1	Homo sapiens	75-80
32368526-15	2020	Increased level of mean IGF-1 appeared on 2microM dose of lycopene at 48 hours observation and began to decline in 72 hours observation.	Lycopene	58-66	insulin like growth factor 1	Homo sapiens	24-29
32410830-2	2020	In addition, lycopene-rich extracts obtained from red guava fruit can induce apoptosis in estrogen receptor-positive breast cancers.	Lycopene	13-21	estrogen receptor 1	Homo sapiens	90-107
31971381-0	2020	Aryl Hydrocarbon Receptor as a Target for Lycopene Preventing DEHP-Induced Spermatogenic Disorders.	Lycopene	42-50	aryl-hydrocarbon receptor	Mus musculus	0-25
31971381-7	2020	Moreover, LYC treatment decreased DEHP-induced nuclear accumulation of aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT), and the expressions of their downstream target genes such as cytochrome P450-dependent monooxygenases (CYP) 1A1, 1A2, and 1B1 were markedly reduced to normal in the LYC treatment group.	Lycopene	10-13	aryl-hydrocarbon receptor	Mus musculus	71-96
31971381-7	2020	Moreover, LYC treatment decreased DEHP-induced nuclear accumulation of aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT), and the expressions of their downstream target genes such as cytochrome P450-dependent monooxygenases (CYP) 1A1, 1A2, and 1B1 were markedly reduced to normal in the LYC treatment group.	Lycopene	10-13	aryl-hydrocarbon receptor	Mus musculus	98-101
31971381-7	2020	Moreover, LYC treatment decreased DEHP-induced nuclear accumulation of aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT), and the expressions of their downstream target genes such as cytochrome P450-dependent monooxygenases (CYP) 1A1, 1A2, and 1B1 were markedly reduced to normal in the LYC treatment group.	Lycopene	10-13	aryl hydrocarbon receptor nuclear translocator	Mus musculus	107-131
31971381-7	2020	Moreover, LYC treatment decreased DEHP-induced nuclear accumulation of aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT), and the expressions of their downstream target genes such as cytochrome P450-dependent monooxygenases (CYP) 1A1, 1A2, and 1B1 were markedly reduced to normal in the LYC treatment group.	Lycopene	10-13	aryl hydrocarbon receptor nuclear translocator	Mus musculus	133-137
31912920-6	2020	Results focused a nonsignificant (p > .05) difference in recovery of testicular Delta5 , 3beta-hydroxysteroid dehydrogenase (HSD), 17beta-HSD after direct exposure of lycopene compared to the CPA-treated group.	Lycopene	167-175	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	131-141
31912920-7	2020	On other side, lycopene exposure to the testicular tissue of CPA-treated rat (CPA+ lycopene-treated) exhibited a significant (p < .05, p < .001) rectification in testicular catalase, superoxide dismutase, peroxidase, glutathione-S-transferase activities towards the vehicle- and lycopene-treated control groups.	Lycopene	15-23	hematopoietic prostaglandin D synthase	Rattus norvegicus	217-242
31912920-7	2020	On other side, lycopene exposure to the testicular tissue of CPA-treated rat (CPA+ lycopene-treated) exhibited a significant (p < .05, p < .001) rectification in testicular catalase, superoxide dismutase, peroxidase, glutathione-S-transferase activities towards the vehicle- and lycopene-treated control groups.	Lycopene	83-91	hematopoietic prostaglandin D synthase	Rattus norvegicus	217-242
31912920-7	2020	On other side, lycopene exposure to the testicular tissue of CPA-treated rat (CPA+ lycopene-treated) exhibited a significant (p < .05, p < .001) rectification in testicular catalase, superoxide dismutase, peroxidase, glutathione-S-transferase activities towards the vehicle- and lycopene-treated control groups.	Lycopene	83-91	hematopoietic prostaglandin D synthase	Rattus norvegicus	217-242
32297350-7	2020	Lycopene (10 muM) inhibited LPA and EGF-induced proliferation of PC-3 cells, confirming previous unpublished results.	Lycopene	0-8	epidermal growth factor	Homo sapiens	36-39
32297350-8	2020	Lycopene also inhibited activation of Akt in response to LPA and EGF as assessed by immunoblotting.	Lycopene	0-8	AKT serine/threonine kinase 1	Homo sapiens	38-41
32297350-8	2020	Lycopene also inhibited activation of Akt in response to LPA and EGF as assessed by immunoblotting.	Lycopene	0-8	epidermal growth factor	Homo sapiens	65-68
32290942-10	2020	Compared with the model group, liver weight, liver index, levels of serum ALT, TG, FBG, IL-6 and IL-1beta were significantly lower in the 20, 60 mg/kg lycopene intervention groups(P<0.	Lycopene	151-159	interleukin 6	Rattus norvegicus	88-92
31044628-3	2020	Double-loaded liposomes encapsulating lycopene beta-CD complex were prepared using soy lecithin, cholesterol, and beta-CD by thin film hydration method.	Lycopene	38-46	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	47-54
31044628-3	2020	Double-loaded liposomes encapsulating lycopene beta-CD complex were prepared using soy lecithin, cholesterol, and beta-CD by thin film hydration method.	Lycopene	38-46	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	114-121
32290942-10	2020	Compared with the model group, liver weight, liver index, levels of serum ALT, TG, FBG, IL-6 and IL-1beta were significantly lower in the 20, 60 mg/kg lycopene intervention groups(P<0.	Lycopene	151-159	interleukin 1 alpha	Rattus norvegicus	97-105
31267355-0	2020	Consumption of lycopene-rich tomatoes improved glucose homeostasis in rats via an increase in leptin levels.	Lycopene	15-23	leptin	Rattus norvegicus	94-100
32016858-0	2020	Lycopene increases metabolic activity of rat liver CYP2B, CYP2D and CYP3A.	Lycopene	0-8	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	68-73
32016858-4	2020	METHODS: We studied the in vivo effect of lycopene on the selected rat liver cytochromes P450 (CYPs): CYP1A2, CYP2B, CYP2C11, CYP2C6, CYP2D, and CYP3A.	Lycopene	42-50	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	102-108
32016858-7	2020	RESULTS: Increased CYP2B, CYP2D, and CYP3A metabolic activities were observed in animals treated with the lycopene dose of 100 mg/kg/day.	Lycopene	106-114	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	37-42
32016858-8	2020	The content of CYP3A1 protein was increased by the dose of 100 mg/kg/day and CYP3A2 protein was increased by all administered doses of lycopene.	Lycopene	135-143	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	77-83
31267355-9	2020	We concluded that in normal rats, a lycopene-rich tomato variety improved glucose tolerance via an increase in plasma leptin levels that enhanced insulin sensitivity but did not affect carotenoid accumulation or lipid metabolism.	Lycopene	36-44	leptin	Rattus norvegicus	118-124
31491956-7	2019	Lycopene reduced the level of intracellular and mitochondrial ROS and decreased the activation of the ROS-mediated EGFR/Ras/extracellular signal-regulated kinase (ERK) and p38 MAPK pathways, thus leading to attenuation of the DNA-binding activity of NF-kappaB p50/p50 and the level of COX-2 gene expression.	Lycopene	0-8	nuclear factor kappa B subunit 1	Homo sapiens	260-263
32082377-10	2019	The exposure of cells to lycopene, an antioxidant compound, restores TERT levels in infected cells, indicating that ROS are implicated in this downregulation.	Lycopene	25-33	telomerase reverse transcriptase	Homo sapiens	69-73
30921005-7	2019	In intention-to-treat analyses, there was only weak evidence that lycopene or green tea influenced some aspects of serum IGF-I, IGF-II, IGFBP-2 or IGFBP-3.	Lycopene	66-74	insulin like growth factor 1	Homo sapiens	121-126
30921005-7	2019	In intention-to-treat analyses, there was only weak evidence that lycopene or green tea influenced some aspects of serum IGF-I, IGF-II, IGFBP-2 or IGFBP-3.	Lycopene	66-74	insulin like growth factor 2	Homo sapiens	128-134
30921005-7	2019	In intention-to-treat analyses, there was only weak evidence that lycopene or green tea influenced some aspects of serum IGF-I, IGF-II, IGFBP-2 or IGFBP-3.	Lycopene	66-74	insulin like growth factor binding protein 2	Homo sapiens	136-143
30921005-7	2019	In intention-to-treat analyses, there was only weak evidence that lycopene or green tea influenced some aspects of serum IGF-I, IGF-II, IGFBP-2 or IGFBP-3.	Lycopene	66-74	insulin like growth factor binding protein 3	Homo sapiens	147-154
30921005-8	2019	In men randomized to lycopene supplements, IGFBP-2 was nonsignificantly (50.9 ng/ml; 95% confidence interval: -51.2-152.9, P=0.3) higher in comparison to placebo, whereas in men randomized to green tea supplements, IGFBP-3 was nonsignificantly (205.2 ng/ml; 95% confidence interval: -583.3-172.9, P=0.3) lower than with placebo.	Lycopene	21-29	insulin like growth factor binding protein 2	Homo sapiens	43-50
30921005-8	2019	In men randomized to lycopene supplements, IGFBP-2 was nonsignificantly (50.9 ng/ml; 95% confidence interval: -51.2-152.9, P=0.3) higher in comparison to placebo, whereas in men randomized to green tea supplements, IGFBP-3 was nonsignificantly (205.2 ng/ml; 95% confidence interval: -583.3-172.9, P=0.3) lower than with placebo.	Lycopene	21-29	insulin like growth factor binding protein 3	Homo sapiens	215-222
31408586-10	2019	Moreover, lycopene promotes IL-4-induced M2 polarization by increasing the phosphorylation levels of STAT6 and Akt in Raw 264.7 macrophages.	Lycopene	10-18	interleukin 4	Mus musculus	28-32
31408586-10	2019	Moreover, lycopene promotes IL-4-induced M2 polarization by increasing the phosphorylation levels of STAT6 and Akt in Raw 264.7 macrophages.	Lycopene	10-18	signal transducer and activator of transcription 6	Mus musculus	101-106
31408586-10	2019	Moreover, lycopene promotes IL-4-induced M2 polarization by increasing the phosphorylation levels of STAT6 and Akt in Raw 264.7 macrophages.	Lycopene	10-18	thymoma viral proto-oncogene 1	Mus musculus	111-114
31491956-0	2019	Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells.	Lycopene	0-8	epidermal growth factor receptor	Homo sapiens	32-64
31491956-0	2019	Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells.	Lycopene	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	83-99
31491956-5	2019	This study aims to investigate whether lycopene inhibits proliferation and induces apoptosis in gastric cancer AGS cells by suppressing the EGFR/Ras/MAPK and NF-kappaB-COX-2 signaling axis.	Lycopene	39-47	epidermal growth factor receptor	Homo sapiens	140-144
31491956-5	2019	This study aims to investigate whether lycopene inhibits proliferation and induces apoptosis in gastric cancer AGS cells by suppressing the EGFR/Ras/MAPK and NF-kappaB-COX-2 signaling axis.	Lycopene	39-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	168-173
31491956-6	2019	Lycopene decreased cell viability and increased apoptotic indices (DNA fragmentation, apoptosis inducing factor, cleavage of caspase-3 and caspase-9, Bax/Bcl-2 ratio).	Lycopene	0-8	caspase 3	Homo sapiens	125-134
31387231-9	2019	Lycopene has shown therapeutic effects on blood and hepatic lipids, increased high-density lipoprotein cholesterol (HDL), mitigated TNF-alpha, and malondialdehyde (MDA) and further improved the hepatic antioxidant capacity.	Lycopene	0-8	tumor necrosis factor	Rattus norvegicus	132-141
31491956-6	2019	Lycopene decreased cell viability and increased apoptotic indices (DNA fragmentation, apoptosis inducing factor, cleavage of caspase-3 and caspase-9, Bax/Bcl-2 ratio).	Lycopene	0-8	caspase 9	Homo sapiens	139-148
31491956-6	2019	Lycopene decreased cell viability and increased apoptotic indices (DNA fragmentation, apoptosis inducing factor, cleavage of caspase-3 and caspase-9, Bax/Bcl-2 ratio).	Lycopene	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	150-153
31491956-6	2019	Lycopene decreased cell viability and increased apoptotic indices (DNA fragmentation, apoptosis inducing factor, cleavage of caspase-3 and caspase-9, Bax/Bcl-2 ratio).	Lycopene	0-8	BCL2 apoptosis regulator	Homo sapiens	154-159
31491956-7	2019	Lycopene reduced the level of intracellular and mitochondrial ROS and decreased the activation of the ROS-mediated EGFR/Ras/extracellular signal-regulated kinase (ERK) and p38 MAPK pathways, thus leading to attenuation of the DNA-binding activity of NF-kappaB p50/p50 and the level of COX-2 gene expression.	Lycopene	0-8	epidermal growth factor receptor	Homo sapiens	115-119
31491956-7	2019	Lycopene reduced the level of intracellular and mitochondrial ROS and decreased the activation of the ROS-mediated EGFR/Ras/extracellular signal-regulated kinase (ERK) and p38 MAPK pathways, thus leading to attenuation of the DNA-binding activity of NF-kappaB p50/p50 and the level of COX-2 gene expression.	Lycopene	0-8	mitogen-activated protein kinase 1	Homo sapiens	163-166
31491956-7	2019	Lycopene reduced the level of intracellular and mitochondrial ROS and decreased the activation of the ROS-mediated EGFR/Ras/extracellular signal-regulated kinase (ERK) and p38 MAPK pathways, thus leading to attenuation of the DNA-binding activity of NF-kappaB p50/p50 and the level of COX-2 gene expression.	Lycopene	0-8	mitogen-activated protein kinase 1	Homo sapiens	172-175
31491956-7	2019	Lycopene reduced the level of intracellular and mitochondrial ROS and decreased the activation of the ROS-mediated EGFR/Ras/extracellular signal-regulated kinase (ERK) and p38 MAPK pathways, thus leading to attenuation of the DNA-binding activity of NF-kappaB p50/p50 and the level of COX-2 gene expression.	Lycopene	0-8	nuclear factor kappa B subunit 1	Homo sapiens	250-263
31491956-7	2019	Lycopene reduced the level of intracellular and mitochondrial ROS and decreased the activation of the ROS-mediated EGFR/Ras/extracellular signal-regulated kinase (ERK) and p38 MAPK pathways, thus leading to attenuation of the DNA-binding activity of NF-kappaB p50/p50 and the level of COX-2 gene expression.	Lycopene	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	285-290
31491956-8	2019	These results show that lycopene-induced apoptosis and inhibition of proliferation occur via inhibition of ROS-activated EGFR/Ras/ERK and p38 MAPK pathways and NF-kappaB-mediated COX-2 gene expression in AGS cells.	Lycopene	24-32	epidermal growth factor receptor	Homo sapiens	121-125
31491956-8	2019	These results show that lycopene-induced apoptosis and inhibition of proliferation occur via inhibition of ROS-activated EGFR/Ras/ERK and p38 MAPK pathways and NF-kappaB-mediated COX-2 gene expression in AGS cells.	Lycopene	24-32	mitogen-activated protein kinase 1	Homo sapiens	130-133
31491956-8	2019	These results show that lycopene-induced apoptosis and inhibition of proliferation occur via inhibition of ROS-activated EGFR/Ras/ERK and p38 MAPK pathways and NF-kappaB-mediated COX-2 gene expression in AGS cells.	Lycopene	24-32	mitogen-activated protein kinase 1	Homo sapiens	138-141
31491956-8	2019	These results show that lycopene-induced apoptosis and inhibition of proliferation occur via inhibition of ROS-activated EGFR/Ras/ERK and p38 MAPK pathways and NF-kappaB-mediated COX-2 gene expression in AGS cells.	Lycopene	24-32	prostaglandin-endoperoxide synthase 2	Homo sapiens	179-184
31480481-0	2019	Oral Administration of Microencapsulated B. Longum BAA-999 and Lycopene Modulates IGF-1/IGF-1R/IGFBP3 Protein Expressions in a Colorectal Murine Model.	Lycopene	63-71	insulin-like growth factor 1	Mus musculus	82-87
31480481-0	2019	Oral Administration of Microencapsulated B. Longum BAA-999 and Lycopene Modulates IGF-1/IGF-1R/IGFBP3 Protein Expressions in a Colorectal Murine Model.	Lycopene	63-71	insulin-like growth factor I receptor	Mus musculus	88-94
31480481-0	2019	Oral Administration of Microencapsulated B. Longum BAA-999 and Lycopene Modulates IGF-1/IGF-1R/IGFBP3 Protein Expressions in a Colorectal Murine Model.	Lycopene	63-71	insulin-like growth factor binding protein 3	Mus musculus	95-101
31186357-5	2019	We first established a lower IPA pathway for the conversion of IPAs to isoprenoid pyrophosphate intermediates that enabled the production of greater than 2 g/L geraniol from prenol as well as limonene, farnesol, diaponeurosporene, and lycopene.	Lycopene	235-243	hypoxia inducible factor 3 subunit alpha	Homo sapiens	63-67
31279748-6	2019	After lycopene treatment, the protein expression of Bax (an apoptotic protein) in SKOV3 cells increased significantly, and the protein expression of Bcl-2 (an anti-apoptotic protein) decreased significantly.	Lycopene	6-14	BCL2 associated X, apoptosis regulator	Homo sapiens	52-55
31279748-6	2019	After lycopene treatment, the protein expression of Bax (an apoptotic protein) in SKOV3 cells increased significantly, and the protein expression of Bcl-2 (an anti-apoptotic protein) decreased significantly.	Lycopene	6-14	BCL2 apoptosis regulator	Homo sapiens	149-154
31741457-0	2019	Lycopene induces apoptosis by inhibiting nuclear translocation of beta-catenin in gastric cancer cells.	Lycopene	0-8	catenin beta 1	Homo sapiens	66-78
31741457-4	2019	In the present study, we showed that lycopene reduces the viability of AGS cells by inducing DNA fragmentation and increasing the Bax/Bcl-2 ratio.	Lycopene	37-45	BCL2 associated X, apoptosis regulator	Homo sapiens	130-133
31741457-4	2019	In the present study, we showed that lycopene reduces the viability of AGS cells by inducing DNA fragmentation and increasing the Bax/Bcl-2 ratio.	Lycopene	37-45	BCL2 apoptosis regulator	Homo sapiens	134-139
31741457-9	2019	Lycopene induces apoptosis by reducing ROS levels and suppressing beta-catenin-c-myc/cyclin D1 axis.	Lycopene	0-8	catenin beta 1	Homo sapiens	66-78
31741457-9	2019	Lycopene induces apoptosis by reducing ROS levels and suppressing beta-catenin-c-myc/cyclin D1 axis.	Lycopene	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	79-84
31741457-9	2019	Lycopene induces apoptosis by reducing ROS levels and suppressing beta-catenin-c-myc/cyclin D1 axis.	Lycopene	0-8	cyclin D1	Homo sapiens	85-94
31741457-10	2019	Thus, lycopene induces apoptosis of gastric cancer cells by disrupting nuclear translocation of beta-catenin and expression of key cell survival genes.	Lycopene	6-14	catenin beta 1	Homo sapiens	96-108
31371925-12	2019	In addition, opening and the decrease of DeltaPsim were attenuated by LP and the expressions of cytochrome c, APAF-1, cleaved caspase-9 and cleaved caspase-3 were also decreased by LP.	Lycopene	181-183	apoptotic peptidase activating factor 1	Rattus norvegicus	110-116
31371925-12	2019	In addition, opening and the decrease of DeltaPsim were attenuated by LP and the expressions of cytochrome c, APAF-1, cleaved caspase-9 and cleaved caspase-3 were also decreased by LP.	Lycopene	181-183	caspase 9	Rattus norvegicus	126-135
31371925-14	2019	Furthermore, LP treatment markedly increased Bcl-2 expression, decreased Bax expression and the Bax/Bcl-2 ratio.	Lycopene	13-15	BCL2, apoptosis regulator	Rattus norvegicus	45-50
31371925-14	2019	Furthermore, LP treatment markedly increased Bcl-2 expression, decreased Bax expression and the Bax/Bcl-2 ratio.	Lycopene	13-15	BCL2 associated X, apoptosis regulator	Rattus norvegicus	73-76
31371925-14	2019	Furthermore, LP treatment markedly increased Bcl-2 expression, decreased Bax expression and the Bax/Bcl-2 ratio.	Lycopene	13-15	BCL2 associated X, apoptosis regulator	Rattus norvegicus	96-99
31371925-14	2019	Furthermore, LP treatment markedly increased Bcl-2 expression, decreased Bax expression and the Bax/Bcl-2 ratio.	Lycopene	13-15	BCL2, apoptosis regulator	Rattus norvegicus	100-105
31371925-15	2019	Conclusion: The results of the present study demonstrated that LP protects against MIRI by inhibiting MPTP opening, partly through the modulation of Bax and Bcl-2.	Lycopene	63-65	BCL2 associated X, apoptosis regulator	Rattus norvegicus	149-152
31371925-15	2019	Conclusion: The results of the present study demonstrated that LP protects against MIRI by inhibiting MPTP opening, partly through the modulation of Bax and Bcl-2.	Lycopene	63-65	BCL2, apoptosis regulator	Rattus norvegicus	157-162
31177203-6	2019	Results showed that dietary lycopene at a high dose significantly inhibited NNK/CS-induced chronic bronchitis, emphysema, and preneoplastic lesions, including squamous metaplasia and atypical adenomatous hyperplasia, as compared with the NNK/CS alone (P < 0.05).	Lycopene	28-36	citrate synthase	Homo sapiens	80-82
31177203-6	2019	Results showed that dietary lycopene at a high dose significantly inhibited NNK/CS-induced chronic bronchitis, emphysema, and preneoplastic lesions, including squamous metaplasia and atypical adenomatous hyperplasia, as compared with the NNK/CS alone (P < 0.05).	Lycopene	28-36	citrate synthase	Homo sapiens	242-244
31177203-8	2019	Furthermore, lycopene feeding significantly inhibited NNK/CS-induced accumulation of total cholesterol, and increased mRNA expression of critical genes related to the RCT (PPARalpha, LXRalpha, and ATP-binding cassette transporters ABCA1 and ABCG1) in the lungs, which were downregulated by the NNK/CS exposure.	Lycopene	13-21	citrate synthase	Homo sapiens	58-60
31177203-8	2019	Furthermore, lycopene feeding significantly inhibited NNK/CS-induced accumulation of total cholesterol, and increased mRNA expression of critical genes related to the RCT (PPARalpha, LXRalpha, and ATP-binding cassette transporters ABCA1 and ABCG1) in the lungs, which were downregulated by the NNK/CS exposure.	Lycopene	13-21	phospholipid-transporting ATPase ABCA1	Mustela putorius furo	231-236
31177203-8	2019	Furthermore, lycopene feeding significantly inhibited NNK/CS-induced accumulation of total cholesterol, and increased mRNA expression of critical genes related to the RCT (PPARalpha, LXRalpha, and ATP-binding cassette transporters ABCA1 and ABCG1) in the lungs, which were downregulated by the NNK/CS exposure.	Lycopene	13-21	ATP-binding cassette sub-family G member 1	Mustela putorius furo	241-246
31177203-8	2019	Furthermore, lycopene feeding significantly inhibited NNK/CS-induced accumulation of total cholesterol, and increased mRNA expression of critical genes related to the RCT (PPARalpha, LXRalpha, and ATP-binding cassette transporters ABCA1 and ABCG1) in the lungs, which were downregulated by the NNK/CS exposure.	Lycopene	13-21	citrate synthase	Homo sapiens	298-300
30939781-0	2019	Lycopene Inhibits Reactive Oxygen Species-Mediated NF-kappaB Signaling and Induces Apoptosis in Pancreatic Cancer Cells.	Lycopene	0-8	nuclear factor kappa B subunit 1	Homo sapiens	51-60
31017253-9	2019	Furthermore, the combination of LP and IPoC inhibited the expression of glucose-regulated protein 78 and C/EBP homologous protein, increased the phosphorylation levels of AKT, ERK1/2 and glycogen synthase kinase-3beta, repressed mitochondrial permeability transition pore opening, and reduced the expression of cytochrome c, cleaved caspase-9 and cleaved caspase-3.	Lycopene	32-34	CCAAT/enhancer binding protein gamma	Rattus norvegicus	105-110
31017253-9	2019	Furthermore, the combination of LP and IPoC inhibited the expression of glucose-regulated protein 78 and C/EBP homologous protein, increased the phosphorylation levels of AKT, ERK1/2 and glycogen synthase kinase-3beta, repressed mitochondrial permeability transition pore opening, and reduced the expression of cytochrome c, cleaved caspase-9 and cleaved caspase-3.	Lycopene	32-34	AKT serine/threonine kinase 1	Rattus norvegicus	171-174
31017253-9	2019	Furthermore, the combination of LP and IPoC inhibited the expression of glucose-regulated protein 78 and C/EBP homologous protein, increased the phosphorylation levels of AKT, ERK1/2 and glycogen synthase kinase-3beta, repressed mitochondrial permeability transition pore opening, and reduced the expression of cytochrome c, cleaved caspase-9 and cleaved caspase-3.	Lycopene	32-34	mitogen activated protein kinase 3	Rattus norvegicus	176-182
31017253-9	2019	Furthermore, the combination of LP and IPoC inhibited the expression of glucose-regulated protein 78 and C/EBP homologous protein, increased the phosphorylation levels of AKT, ERK1/2 and glycogen synthase kinase-3beta, repressed mitochondrial permeability transition pore opening, and reduced the expression of cytochrome c, cleaved caspase-9 and cleaved caspase-3.	Lycopene	32-34	glycogen synthase kinase 3 beta	Rattus norvegicus	187-217
31017253-9	2019	Furthermore, the combination of LP and IPoC inhibited the expression of glucose-regulated protein 78 and C/EBP homologous protein, increased the phosphorylation levels of AKT, ERK1/2 and glycogen synthase kinase-3beta, repressed mitochondrial permeability transition pore opening, and reduced the expression of cytochrome c, cleaved caspase-9 and cleaved caspase-3.	Lycopene	32-34	caspase 9	Rattus norvegicus	333-342
31006097-0	2019	Lycopene protects against t-BHP-induced neuronal oxidative damage and apoptosis via activation of the PI3K/Akt pathway.	Lycopene	0-8	thymoma viral proto-oncogene 1	Mus musculus	107-110
31006097-7	2019	Furthermore, lycopene reduced the ratios of Bax:Bcl-2 and cleaved caspase-3:caspase-3 and the level of cytochrome C, increased the levels of synaptophysin (SYP) and postsynaptic density 95 (PSD95) and activated the PI3K/Akt pathway.	Lycopene	13-21	BCL2-associated X protein	Mus musculus	44-47
31006097-7	2019	Furthermore, lycopene reduced the ratios of Bax:Bcl-2 and cleaved caspase-3:caspase-3 and the level of cytochrome C, increased the levels of synaptophysin (SYP) and postsynaptic density 95 (PSD95) and activated the PI3K/Akt pathway.	Lycopene	13-21	B cell leukemia/lymphoma 2	Mus musculus	48-53
31006097-7	2019	Furthermore, lycopene reduced the ratios of Bax:Bcl-2 and cleaved caspase-3:caspase-3 and the level of cytochrome C, increased the levels of synaptophysin (SYP) and postsynaptic density 95 (PSD95) and activated the PI3K/Akt pathway.	Lycopene	13-21	caspase 3	Mus musculus	66-75
30889234-8	2019	Also, lycopene treatment increased the expression of RXR-alpha, RXR-beta, and PPARgamma, important biomarkers of liver regeneration.	Lycopene	6-14	retinoid X receptor alpha	Homo sapiens	53-62
30889234-8	2019	Also, lycopene treatment increased the expression of RXR-alpha, RXR-beta, and PPARgamma, important biomarkers of liver regeneration.	Lycopene	6-14	retinoid X receptor beta	Homo sapiens	64-72
30889234-8	2019	Also, lycopene treatment increased the expression of RXR-alpha, RXR-beta, and PPARgamma, important biomarkers of liver regeneration.	Lycopene	6-14	peroxisome proliferator activated receptor gamma	Homo sapiens	78-87
31006097-7	2019	Furthermore, lycopene reduced the ratios of Bax:Bcl-2 and cleaved caspase-3:caspase-3 and the level of cytochrome C, increased the levels of synaptophysin (SYP) and postsynaptic density 95 (PSD95) and activated the PI3K/Akt pathway.	Lycopene	13-21	caspase 3	Mus musculus	76-85
31006097-7	2019	Furthermore, lycopene reduced the ratios of Bax:Bcl-2 and cleaved caspase-3:caspase-3 and the level of cytochrome C, increased the levels of synaptophysin (SYP) and postsynaptic density 95 (PSD95) and activated the PI3K/Akt pathway.	Lycopene	13-21	synaptophysin	Mus musculus	141-154
31006097-7	2019	Furthermore, lycopene reduced the ratios of Bax:Bcl-2 and cleaved caspase-3:caspase-3 and the level of cytochrome C, increased the levels of synaptophysin (SYP) and postsynaptic density 95 (PSD95) and activated the PI3K/Akt pathway.	Lycopene	13-21	synaptophysin	Mus musculus	156-159
31006097-7	2019	Furthermore, lycopene reduced the ratios of Bax:Bcl-2 and cleaved caspase-3:caspase-3 and the level of cytochrome C, increased the levels of synaptophysin (SYP) and postsynaptic density 95 (PSD95) and activated the PI3K/Akt pathway.	Lycopene	13-21	discs large MAGUK scaffold protein 4	Mus musculus	165-188
31006097-7	2019	Furthermore, lycopene reduced the ratios of Bax:Bcl-2 and cleaved caspase-3:caspase-3 and the level of cytochrome C, increased the levels of synaptophysin (SYP) and postsynaptic density 95 (PSD95) and activated the PI3K/Akt pathway.	Lycopene	13-21	discs large MAGUK scaffold protein 4	Mus musculus	190-195
31006097-7	2019	Furthermore, lycopene reduced the ratios of Bax:Bcl-2 and cleaved caspase-3:caspase-3 and the level of cytochrome C, increased the levels of synaptophysin (SYP) and postsynaptic density 95 (PSD95) and activated the PI3K/Akt pathway.	Lycopene	13-21	thymoma viral proto-oncogene 1	Mus musculus	220-223
31006097-8	2019	In conclusion, lycopene attenuated oxidative stress and reduced t-BHP-induced cell apoptosis, and the mechanism is likely related to activation of the PI3K/Akt pathway.	Lycopene	15-23	thymoma viral proto-oncogene 1	Mus musculus	156-159
31012961-8	2019	Inflammatory factors (TNF-alpha and CRP) in DM rats were also decreased by lycopene intervention.	Lycopene	75-83	tumor necrosis factor	Rattus norvegicus	22-31
31012961-8	2019	Inflammatory factors (TNF-alpha and CRP) in DM rats were also decreased by lycopene intervention.	Lycopene	75-83	C-reactive protein	Rattus norvegicus	36-39
31012961-9	2019	Total antioxidative capacity as well as the activities of antioxidants in DM rats including CAT, SOD, and GPx were increased after lycopene intervention.	Lycopene	131-139	catalase	Rattus norvegicus	92-95
30939781-4	2019	The present study was designed to determine if lycopene induces apoptosis of pancreatic cancer PANC-1 cells by decreasing intracellular and mitochondrial ROS levels, and consequently suppressing NF-kappaB activation and expression of NF-kappaB target genes including cIAP1, cIAP2, and survivin.	Lycopene	47-55	nuclear factor kappa B subunit 1	Homo sapiens	195-204
30939781-4	2019	The present study was designed to determine if lycopene induces apoptosis of pancreatic cancer PANC-1 cells by decreasing intracellular and mitochondrial ROS levels, and consequently suppressing NF-kappaB activation and expression of NF-kappaB target genes including cIAP1, cIAP2, and survivin.	Lycopene	47-55	nuclear factor kappa B subunit 1	Homo sapiens	234-243
30939781-4	2019	The present study was designed to determine if lycopene induces apoptosis of pancreatic cancer PANC-1 cells by decreasing intracellular and mitochondrial ROS levels, and consequently suppressing NF-kappaB activation and expression of NF-kappaB target genes including cIAP1, cIAP2, and survivin.	Lycopene	47-55	baculoviral IAP repeat containing 2	Homo sapiens	267-272
30939781-4	2019	The present study was designed to determine if lycopene induces apoptosis of pancreatic cancer PANC-1 cells by decreasing intracellular and mitochondrial ROS levels, and consequently suppressing NF-kappaB activation and expression of NF-kappaB target genes including cIAP1, cIAP2, and survivin.	Lycopene	47-55	baculoviral IAP repeat containing 3	Homo sapiens	274-279
30939781-5	2019	The results show that the lycopene decreased intracellular and mitochondrial ROS levels, mitochondrial function (determined by the mitochondrial membrane potential and oxygen consumption rate), NF-kappaB activity, and expression of NF-kappaB-dependent survival genes in PANC-1 cells.	Lycopene	26-34	nuclear factor kappa B subunit 1	Homo sapiens	194-203
30939781-5	2019	The results show that the lycopene decreased intracellular and mitochondrial ROS levels, mitochondrial function (determined by the mitochondrial membrane potential and oxygen consumption rate), NF-kappaB activity, and expression of NF-kappaB-dependent survival genes in PANC-1 cells.	Lycopene	26-34	nuclear factor kappa B subunit 1	Homo sapiens	232-241
30939781-6	2019	Lycopene reduced cell viability with increases in active caspase-3 and the Bax to Bcl-2 ratio in PANC-1 cells.	Lycopene	0-8	caspase 3	Homo sapiens	57-66
30939781-6	2019	Lycopene reduced cell viability with increases in active caspase-3 and the Bax to Bcl-2 ratio in PANC-1 cells.	Lycopene	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	75-78
30939781-6	2019	Lycopene reduced cell viability with increases in active caspase-3 and the Bax to Bcl-2 ratio in PANC-1 cells.	Lycopene	0-8	BCL2 apoptosis regulator	Homo sapiens	82-87
30660958-6	2019	Lycopene was able to minimize redox processes by decreasing lipid peroxidation and DNA damage, and by having an increase in the activities of SOD, CAT and GSH content.	Lycopene	0-8	catalase	Mus musculus	147-150
30409612-4	2019	When lycopene was paired with the methoxylated anthocyanins, the anti-inflammatory effect on the inhibition of the cytokine IL-8, which is a pro-inflammatory biomarker, was increased by 15-69% of the expected additive activity, indicating synergistic interaction between the compounds.	Lycopene	5-13	C-X-C motif chemokine ligand 8	Homo sapiens	124-128
30948928-0	2019	Lycopene improves the efficiency of anti-PD-1 therapy via activating IFN signaling of lung cancer cells.	Lycopene	0-8	programmed cell death 1	Mus musculus	41-45
30948928-2	2019	In this study, we aimed to investigate whether lycopene could promote the effect of anti-PD-1 treatment on lung cancer.	Lycopene	47-55	programmed cell death 1	Mus musculus	89-93
30948928-8	2019	Cell apoptosis in the tumor tissues was significantly enhanced in mice with combined lycopene and anti-PD-1 treatment in comparison with those of either lycopene or anti-PD-1 alone.	Lycopene	85-93	programmed cell death 1	Mus musculus	170-174
30948928-9	2019	Furthermore, lycopene could assist anti-PD-1 to elevate the levels of interleukin (IL)-1 and interferon (IFN) gamma while reduce the levels of IL-4 and IL-10 in the spleen of mice injected with LLC cells.	Lycopene	13-21	programmed cell death 1	Mus musculus	40-44
30948928-9	2019	Furthermore, lycopene could assist anti-PD-1 to elevate the levels of interleukin (IL)-1 and interferon (IFN) gamma while reduce the levels of IL-4 and IL-10 in the spleen of mice injected with LLC cells.	Lycopene	13-21	interleukin 4	Mus musculus	143-147
30948928-9	2019	Furthermore, lycopene could assist anti-PD-1 to elevate the levels of interleukin (IL)-1 and interferon (IFN) gamma while reduce the levels of IL-4 and IL-10 in the spleen of mice injected with LLC cells.	Lycopene	13-21	interleukin 10	Mus musculus	152-157
30948928-10	2019	Lycopene treatment increased the CD4+/CD8+ ratio in the spleen and promoted IFNgamma-expressing CD8+ T cells in tumor tissues.	Lycopene	0-8	interferon gamma	Mus musculus	76-84
30948928-11	2019	Upon IFNgamma stimulation, lycopene diminished PD-L1 expression via activating JAK and repressing phosphorylation of AKT.	Lycopene	27-35	interferon gamma	Mus musculus	5-13
30948928-11	2019	Upon IFNgamma stimulation, lycopene diminished PD-L1 expression via activating JAK and repressing phosphorylation of AKT.	Lycopene	27-35	CD274 antigen	Mus musculus	47-52
30948928-11	2019	Upon IFNgamma stimulation, lycopene diminished PD-L1 expression via activating JAK and repressing phosphorylation of AKT.	Lycopene	27-35	thymoma viral proto-oncogene 1	Mus musculus	117-120
30948928-12	2019	Conclusion: Our results have demonstrated that lycopene could be used as a potential adjuvant drug to synergistically improve the efficiency of anti-PD-1 therapy.	Lycopene	47-55	programmed cell death 1	Mus musculus	149-153
30651415-8	2019	Treatment with lycopene, a non-polar carotenoid, and fucoxanthinol, a C-8-keto carotenoid, also suppressed lipopolysaccharide-induced translocation of Toll-like receptor 4 into lipid rafts, and subsequent nitric oxide production in RAW264 macrophages.	Lycopene	15-23	toll like receptor 4	Homo sapiens	151-171
30512227-5	2019	Peroxisome proliferator-activated receptor (PPAR) signaling is identified as a major actor mediating the effects of lycopene isomers.	Lycopene	116-124	peroxisome proliferator activated receptor alpha	Homo sapiens	0-42
30512227-5	2019	Peroxisome proliferator-activated receptor (PPAR) signaling is identified as a major actor mediating the effects of lycopene isomers.	Lycopene	116-124	peroxisome proliferator activated receptor alpha	Homo sapiens	44-48
30512227-8	2019	Finally, lycopene isomers restore the TNF-alpha-blunted uptake of glucose by adipocytes via a modulation of AKT phosphorylation.	Lycopene	9-17	tumor necrosis factor	Homo sapiens	38-47
30512227-9	2019	CONCLUSION: These results show that lycopene isomers exert similar biological functions in adipocytes, linked to their ability to transactivate PPARgamma.	Lycopene	36-44	peroxisome proliferator activated receptor gamma	Homo sapiens	144-153
30801647-4	2019	RESULTS: Two BCO1 SNP genotypes were significant predictors of the change in plasma lycopene, with SNP effects differing in magnitude and direction, depending on the level of juice intake (rs12934922 x diet group P = 0.02; rs6564851 x diet group P = 0.046).	Lycopene	84-92	beta-carotene oxygenase 1	Homo sapiens	13-17
30801647-6	2019	CONCLUSIONS: In conclusion, SNPs in BCO1 and other genes may modulate human plasma and prostate tissue responses to dietary lycopene intake and warrant validation in larger, human controlled feeding intervention and cohort studies.	Lycopene	124-132	beta-carotene oxygenase 1	Homo sapiens	36-40
30705834-9	2019	Arthrobacter strains produced C50 carotenoids such as decaprenoxanthin and its glucosylated derivatives, as well as some C40 carotenoids such as lycopene which is used as synthesis precursors of the C50 carotenoids.	Lycopene	145-153	CCR4-NOT transcription complex subunit 11	Homo sapiens	121-124
31161929-13	2018	When comparing NC and NL groups, negative effects were observed in the group given lycopene in terms of MLI, PCNA, apoptosis, and IL-6 (all parameters, p = 0.001).	Lycopene	83-91	proliferating cell nuclear antigen	Rattus norvegicus	109-113
30719147-0	2019	Lycopene upregulates ZO-1 and downregulates claudin-1 through autophagy inhibition in the human cutaneous squamous cell carcinoma cell line COLO-16.	Lycopene	0-8	tight junction protein 1	Homo sapiens	21-25
30719147-0	2019	Lycopene upregulates ZO-1 and downregulates claudin-1 through autophagy inhibition in the human cutaneous squamous cell carcinoma cell line COLO-16.	Lycopene	0-8	claudin 1	Homo sapiens	44-53
30719147-5	2019	In addition, lycopene upregulated the protein levels of ZO-1 in COLO-16 and HaCaT cells but not in HEKs.	Lycopene	13-21	tight junction protein 1	Homo sapiens	56-60
30719147-6	2019	In contrast, lycopene upregulated the protein level of claudin-1 in HEKs but downregulated claudin-1 in COLO-16 cells.	Lycopene	13-21	claudin 1	Homo sapiens	55-64
30719147-6	2019	In contrast, lycopene upregulated the protein level of claudin-1 in HEKs but downregulated claudin-1 in COLO-16 cells.	Lycopene	13-21	claudin 1	Homo sapiens	91-100
30719147-8	2019	Importantly, autophagy inhibition contributed to the lycopene-induced regulation on ZO-1 and claudin-1 in COLO-16 cells.	Lycopene	53-61	tight junction protein 1	Homo sapiens	84-88
30719147-8	2019	Importantly, autophagy inhibition contributed to the lycopene-induced regulation on ZO-1 and claudin-1 in COLO-16 cells.	Lycopene	53-61	claudin 1	Homo sapiens	93-102
30719147-9	2019	Moreover, JNK inhibitor (SP600125) and MEK inhibitor (U0126) treatment abolished the increase in phosphorylated MTOR and ribosomal protein S6 as well as the increase in ZO-1 and the decrease in claudin-1 in lycopene-treated COLO-16 cells.	Lycopene	207-215	mitogen-activated protein kinase 8	Homo sapiens	10-13
30719147-9	2019	Moreover, JNK inhibitor (SP600125) and MEK inhibitor (U0126) treatment abolished the increase in phosphorylated MTOR and ribosomal protein S6 as well as the increase in ZO-1 and the decrease in claudin-1 in lycopene-treated COLO-16 cells.	Lycopene	207-215	claudin 1	Homo sapiens	194-203
30719147-11	2019	In conclusion, lycopene upregulates ZO-1 expression and downregulates claudin-1 expression through the activation of ERK, JNK and MTORC1 as well as the inhibition of autophagy in human cSCC cells.	Lycopene	15-23	tight junction protein 1	Homo sapiens	36-40
30719147-11	2019	In conclusion, lycopene upregulates ZO-1 expression and downregulates claudin-1 expression through the activation of ERK, JNK and MTORC1 as well as the inhibition of autophagy in human cSCC cells.	Lycopene	15-23	claudin 1	Homo sapiens	70-79
30719147-11	2019	In conclusion, lycopene upregulates ZO-1 expression and downregulates claudin-1 expression through the activation of ERK, JNK and MTORC1 as well as the inhibition of autophagy in human cSCC cells.	Lycopene	15-23	mitogen-activated protein kinase 1	Homo sapiens	117-120
30719147-11	2019	In conclusion, lycopene upregulates ZO-1 expression and downregulates claudin-1 expression through the activation of ERK, JNK and MTORC1 as well as the inhibition of autophagy in human cSCC cells.	Lycopene	15-23	mitogen-activated protein kinase 8	Homo sapiens	122-125
30462120-0	2018	Lycopene attenuates AFB1-induced renal injury with the activation of the Nrf2 antioxidant signaling pathway in mice.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-77
30462120-3	2018	Lycopene (LYC), a natural carotenoid, has received extensive attention due to its antioxidant effect with the activation of Nrf2.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	124-128
30462120-3	2018	Lycopene (LYC), a natural carotenoid, has received extensive attention due to its antioxidant effect with the activation of Nrf2.	Lycopene	10-13	nuclear factor, erythroid derived 2, like 2	Mus musculus	124-128
30343427-5	2019	Lycopene production was further improved by inhibiting ergosterol production via downregulation of ERG9 expression and by deleting ROX1 or MOT3 genes encoding transcriptional repressors for mevalonate and sterol biosynthetic pathways.	Lycopene	0-8	bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase	Saccharomyces cerevisiae S288C	99-103
30343427-5	2019	Lycopene production was further improved by inhibiting ergosterol production via downregulation of ERG9 expression and by deleting ROX1 or MOT3 genes encoding transcriptional repressors for mevalonate and sterol biosynthetic pathways.	Lycopene	0-8	Rox1p	Saccharomyces cerevisiae S288C	131-135
30343427-5	2019	Lycopene production was further improved by inhibiting ergosterol production via downregulation of ERG9 expression and by deleting ROX1 or MOT3 genes encoding transcriptional repressors for mevalonate and sterol biosynthetic pathways.	Lycopene	0-8	Mot3p	Saccharomyces cerevisiae S288C	139-143
30343427-8	2019	In combination with the overexpression of STB5 gene encoding a transcription factor involved in NADPH production, the final strain produced up to 41.8 mg/gDCW of lycopene, which is approximately 74.6-fold higher than that produced in the initial strain.	Lycopene	162-170	Stb5p	Saccharomyces cerevisiae S288C	42-46
30625493-0	2019	Anti-Inflammatory Effect of Lycopene on Experimental Spinal Cord Ischemia Injury via Cyclooxygenase-2 Suppression.	Lycopene	28-36	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	85-101
30625493-5	2019	Furthermore, Western blot assay revealed that lycopene treatment attenuated the SCII-induced increase in the protein levels of cyclooxygenase-2 (COX-2), nuclear factor-kappaB, and activate protein-1, as well as the reduction of heme oxygenase-1.	Lycopene	46-54	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	127-143
30625493-5	2019	Furthermore, Western blot assay revealed that lycopene treatment attenuated the SCII-induced increase in the protein levels of cyclooxygenase-2 (COX-2), nuclear factor-kappaB, and activate protein-1, as well as the reduction of heme oxygenase-1.	Lycopene	46-54	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	145-150
30625493-5	2019	Furthermore, Western blot assay revealed that lycopene treatment attenuated the SCII-induced increase in the protein levels of cyclooxygenase-2 (COX-2), nuclear factor-kappaB, and activate protein-1, as well as the reduction of heme oxygenase-1.	Lycopene	46-54	heme oxygenase 1	Rattus norvegicus	228-244
30625493-6	2019	CONCLUSION: Lycopene exerted neuroprotective functions in SCII and inhibited SCII-elicited neuroinflammation via COX-2 suppression.	Lycopene	12-20	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	113-118
30474364-3	2018	Serum lycopene concentration was negatively correlated with the levels of serum TC, TG, LDL-C, as well as the cerebral LDL-C, VEGF, and VCAM-1.	Lycopene	6-14	vascular endothelial growth factor A	Rattus norvegicus	126-130
30474364-3	2018	Serum lycopene concentration was negatively correlated with the levels of serum TC, TG, LDL-C, as well as the cerebral LDL-C, VEGF, and VCAM-1.	Lycopene	6-14	vascular cell adhesion molecule 1	Rattus norvegicus	136-142
30474364-4	2018	Serum lycopene concentration was positively correlated with the expression of Claudin-5 and the number of neurons in hippocampal CA1 and CA3.	Lycopene	6-14	claudin 5	Rattus norvegicus	78-87
30474364-4	2018	Serum lycopene concentration was positively correlated with the expression of Claudin-5 and the number of neurons in hippocampal CA1 and CA3.	Lycopene	6-14	carbonic anhydrase 1	Rattus norvegicus	129-132
30474364-4	2018	Serum lycopene concentration was positively correlated with the expression of Claudin-5 and the number of neurons in hippocampal CA1 and CA3.	Lycopene	6-14	carbonic anhydrase 3	Rattus norvegicus	137-140
31161929-13	2018	When comparing NC and NL groups, negative effects were observed in the group given lycopene in terms of MLI, PCNA, apoptosis, and IL-6 (all parameters, p = 0.001).	Lycopene	83-91	interleukin 6	Rattus norvegicus	130-134
30251044-7	2018	Furthermore, TD induced apoptosis in liver tissues as shown by DNA fragmentation and upregulation of proapoptotic Bax and Casp-3 while lycopene upregulated the antiapoptotic Bcl-2.	Lycopene	135-143	BCL2, apoptosis regulator	Rattus norvegicus	174-179
30360616-0	2018	Lycopene Triggers Nrf2-AMPK Cross Talk to Alleviate Atrazine-Induced Nephrotoxicity in Mice.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
29322841-0	2018	The effect of lycopene on cytochrome P450 isoenzymes and P-glycoprotein by using human liver microsomes and Caco-2 cell monolayer model.	Lycopene	14-22	ATP binding cassette subfamily B member 1	Homo sapiens	57-71
29322841-3	2018	The present study was performed to investigate the effects of lycopene on the CYP enzymes and P-gp activity.	Lycopene	62-70	ATP binding cassette subfamily B member 1	Homo sapiens	94-98
29322841-5	2018	Caco-2 cell monolayer model was carried out to assay lycopene on P-gp activity.	Lycopene	53-61	ATP binding cassette subfamily B member 1	Homo sapiens	65-69
29322841-6	2018	The results indicated that lycopene had a moderate inhibitory effect on CYP2E1, with IC50 value of 43.65 muM, whereas no inhibitory effects on CYP3A4, CYP2C19, CYP2D6 and CYP2E1, with IC50 values all over 100 muM.	Lycopene	27-35	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	72-78
29322841-8	2018	In conclusion, there should be required attention when lycopene are coadministered with other drugs that are metabolised by CYP2E1.	Lycopene	55-63	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	124-130
30098995-7	2018	Moreover, 1.0 mg/mL + 5 mug/mL LP + ALA addition increased SOD, CAT, and GSH-Px in spermatozoa more than 1.0 mg/mL LP and 10 mug/mL ALA (P &lt; 0.05).	Lycopene	31-33	catalase	Capra hircus	64-67
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	169-177	tumor necrosis factor	Mus musculus	110-119
30198495-4	2018	Annexin V/propidium iodide double-staining assays revealed the strong apoptotic effects of lycopene.	Lycopene	91-99	annexin A5	Mus musculus	0-9
30115814-0	2018	Lycopene ameliorates oxidative stress in the aging chicken ovary via activation of Nrf2/HO-1 pathway.	Lycopene	0-8	heme oxygenase 1	Gallus gallus	88-92
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	125-133	interleukin 1 complex	Mus musculus	46-59
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	125-133	interleukin 1 complex	Mus musculus	61-64
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	125-133	interleukin 6	Mus musculus	67-70
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	125-133	chemokine (C-X-C motif) ligand 15	Mus musculus	72-75
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	125-133	tumor necrosis factor	Mus musculus	81-108
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	125-133	tumor necrosis factor	Mus musculus	110-119
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	169-177	interleukin 1 complex	Mus musculus	46-59
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	169-177	interleukin 1 complex	Mus musculus	61-64
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	169-177	interleukin 6	Mus musculus	67-70
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	169-177	chemokine (C-X-C motif) ligand 15	Mus musculus	72-75
30198495-5	2018	The levels of inflammatory factors, including interleukin-1 (IL1), IL6, IL8, and tumor necrosis factor-alpha (TNF-alpha), in lycopene-treated cells were also reduced by lycopene treatment.	Lycopene	169-177	tumor necrosis factor	Mus musculus	81-108
29978907-6	2018	Overexpression of SlREM1 in tomato stimulates fruit ripening with an increase in ethylene production and lycopene accumulation as compared to the wild-type.	Lycopene	105-113	remorin 1	Solanum lycopersicum	18-24
29978907-7	2018	Consistently, these genes involved in ethylene and lycopene biosynthesis and ripening regulators also are upregulated in SlREM1 overexpression lines.	Lycopene	51-59	remorin 1	Solanum lycopersicum	121-127
30115814-7	2018	Lycopene rescued the decreased antioxidant capacity by increasing the activities of antioxidases and activating the Nrf2/HO-1 pathway in both D-gal-induced and naturally aged ovaries.	Lycopene	0-8	heme oxygenase 1	Gallus gallus	121-125
30115814-10	2018	In conclusion, lycopene can effectively ameliorate the oxidative stress in aging hen ovaries via the activation of the Nrf2/HO-1 pathway.	Lycopene	15-23	heme oxygenase 1	Gallus gallus	124-128
29948678-3	2018	Mice of lycopene group were gavaged with 20 mg/kg/day lycopene from PD1 to PD7 and then given 500 mg/kg/day BPA from PD8 to PD14.	Lycopene	8-16	programmed cell death 1	Mus musculus	68-71
29948678-3	2018	Mice of lycopene group were gavaged with 20 mg/kg/day lycopene from PD1 to PD7 and then given 500 mg/kg/day BPA from PD8 to PD14.	Lycopene	54-62	programmed cell death 1	Mus musculus	68-71
29948678-9	2018	Lycopene decreased Bax in testis and ovary and increased Bcl-2 in ovary tissues in the offspring mice.	Lycopene	0-8	BCL2-associated X protein	Mus musculus	19-22
29948678-9	2018	Lycopene decreased Bax in testis and ovary and increased Bcl-2 in ovary tissues in the offspring mice.	Lycopene	0-8	B cell leukemia/lymphoma 2	Mus musculus	57-62
30140366-5	2018	We found that lycopene promoted the secretion of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) from NSCs.	Lycopene	14-22	brain derived neurotrophic factor	Homo sapiens	76-109
29273675-0	2018	Vitamin E and lycopene reduce coal burning fluorosis-induced spermatogenic cell apoptosis via oxidative stress-mediated JNK and ERK signaling pathways.	Lycopene	14-22	mitogen-activated protein kinase 8	Rattus norvegicus	120-123
29273675-0	2018	Vitamin E and lycopene reduce coal burning fluorosis-induced spermatogenic cell apoptosis via oxidative stress-mediated JNK and ERK signaling pathways.	Lycopene	14-22	Eph receptor B1	Rattus norvegicus	128-131
29273675-9	2018	Further, fluoride caused the enhanced Jun N-terminal kinase (JNK, c-Jun) and extracellular signal-regulated protein kinase (ERK) phosphorylation, which was reduced by VE or lycopene.	Lycopene	173-181	mitogen-activated protein kinase 8	Rattus norvegicus	38-59
29273675-9	2018	Further, fluoride caused the enhanced Jun N-terminal kinase (JNK, c-Jun) and extracellular signal-regulated protein kinase (ERK) phosphorylation, which was reduced by VE or lycopene.	Lycopene	173-181	mitogen-activated protein kinase 8	Rattus norvegicus	61-64
29273675-9	2018	Further, fluoride caused the enhanced Jun N-terminal kinase (JNK, c-Jun) and extracellular signal-regulated protein kinase (ERK) phosphorylation, which was reduced by VE or lycopene.	Lycopene	173-181	Eph receptor B1	Rattus norvegicus	77-122
29273675-9	2018	Further, fluoride caused the enhanced Jun N-terminal kinase (JNK, c-Jun) and extracellular signal-regulated protein kinase (ERK) phosphorylation, which was reduced by VE or lycopene.	Lycopene	173-181	Eph receptor B1	Rattus norvegicus	124-127
29273675-10	2018	Thus, VE and lycopene prevent coal burning fluorosis-induced spermatogenic cell apoptosis through the suppression of oxidative stress-mediated JNK and ERK signaling pathway, which could be an alternative therapeutic strategy for the treatment of fluorosis.	Lycopene	13-21	mitogen-activated protein kinase 8	Rattus norvegicus	143-146
29273675-10	2018	Thus, VE and lycopene prevent coal burning fluorosis-induced spermatogenic cell apoptosis through the suppression of oxidative stress-mediated JNK and ERK signaling pathway, which could be an alternative therapeutic strategy for the treatment of fluorosis.	Lycopene	13-21	Eph receptor B1	Rattus norvegicus	151-154
30140366-5	2018	We found that lycopene promoted the secretion of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) from NSCs.	Lycopene	14-22	brain derived neurotrophic factor	Homo sapiens	111-115
30140366-5	2018	We found that lycopene promoted the secretion of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) from NSCs.	Lycopene	14-22	vascular endothelial growth factor A	Homo sapiens	122-156
30140366-5	2018	We found that lycopene promoted the secretion of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) from NSCs.	Lycopene	14-22	vascular endothelial growth factor A	Homo sapiens	158-162
29866038-0	2018	Tomato (Solanum lycopersicum) SlIPT4, encoding an isopentenyltransferase, is involved in leaf senescence and lycopene biosynthesis during fruit ripening.	Lycopene	109-117	adenylate isopentenyltransferase	Solanum lycopersicum	30-36
29866038-7	2018	However, down-expression of SlIPT4 generated never-red orange fruits, corresponding with a dramatic reduction of lycopene.	Lycopene	113-121	adenylate isopentenyltransferase	Solanum lycopersicum	28-34
29866038-8	2018	Among lycopene biosynthesis-related genes, the fact of remarkable decrease of ZISO transcript and upregulation of other genes, revealed that SlIPT4 regulates positively lycopene biosynthesis via directly affecting ZISO expression, and also supported the existence of regulatory loops in lycopene biosynthesis pathway.	Lycopene	6-14	adenylate isopentenyltransferase	Solanum lycopersicum	141-147
29866038-8	2018	Among lycopene biosynthesis-related genes, the fact of remarkable decrease of ZISO transcript and upregulation of other genes, revealed that SlIPT4 regulates positively lycopene biosynthesis via directly affecting ZISO expression, and also supported the existence of regulatory loops in lycopene biosynthesis pathway.	Lycopene	169-177	adenylate isopentenyltransferase	Solanum lycopersicum	141-147
29866038-8	2018	Among lycopene biosynthesis-related genes, the fact of remarkable decrease of ZISO transcript and upregulation of other genes, revealed that SlIPT4 regulates positively lycopene biosynthesis via directly affecting ZISO expression, and also supported the existence of regulatory loops in lycopene biosynthesis pathway.	Lycopene	169-177	adenylate isopentenyltransferase	Solanum lycopersicum	141-147
29866038-9	2018	Meanwhile, the accumulation of abscisic acid (ABA) was reduced and the transcripts PSY1 were increased in SlIPT4-RNAi fruits, supporting the feedback regulation between ABA and lycopene biosynthesis.	Lycopene	177-185	adenylate isopentenyltransferase	Solanum lycopersicum	106-112
29866038-10	2018	CONCLUSION: The study revealed the crucial roles of SlIPT4 in leaf senescence and the regulatory network of lycopene biosynthesis in tomato, providing a new light on the lycopene biosynthesis and fruit ripening.	Lycopene	170-178	adenylate isopentenyltransferase	Solanum lycopersicum	52-58
29439880-0	2018	Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha level by lycopene is comparable to methylprednisolone in acute pancreatitis.	Lycopene	88-96	nitric oxide synthase 2	Rattus norvegicus	15-46
29439880-10	2018	RESULTS: Lycopene group showed a significant reduction in tumor necrosis factor alpha (TNF-alpha), myeloperoxidase activity, and down-regulation of inducible nitric oxide synthase (iNOS) gene expression.	Lycopene	9-17	tumor necrosis factor	Rattus norvegicus	58-85
29439880-10	2018	RESULTS: Lycopene group showed a significant reduction in tumor necrosis factor alpha (TNF-alpha), myeloperoxidase activity, and down-regulation of inducible nitric oxide synthase (iNOS) gene expression.	Lycopene	9-17	tumor necrosis factor	Rattus norvegicus	87-96
29439880-10	2018	RESULTS: Lycopene group showed a significant reduction in tumor necrosis factor alpha (TNF-alpha), myeloperoxidase activity, and down-regulation of inducible nitric oxide synthase (iNOS) gene expression.	Lycopene	9-17	myeloperoxidase	Rattus norvegicus	99-114
29439880-10	2018	RESULTS: Lycopene group showed a significant reduction in tumor necrosis factor alpha (TNF-alpha), myeloperoxidase activity, and down-regulation of inducible nitric oxide synthase (iNOS) gene expression.	Lycopene	9-17	nitric oxide synthase 2	Rattus norvegicus	148-179
29439880-10	2018	RESULTS: Lycopene group showed a significant reduction in tumor necrosis factor alpha (TNF-alpha), myeloperoxidase activity, and down-regulation of inducible nitric oxide synthase (iNOS) gene expression.	Lycopene	9-17	nitric oxide synthase 2	Rattus norvegicus	181-185
29731858-2	2018	In the present study, the role of peroxisome proliferator-activated receptor gamma (PPARgamma) in the effect of lycopene and beta-carotene on the viability of EC109 human esophageal squamous carcinoma cells was investigated.	Lycopene	112-120	peroxisome proliferator activated receptor gamma	Homo sapiens	34-82
29315481-5	2018	When Gal4M9 was used to control the expression of PGAL -driven pathway genes, growth and production was successfully decoupled upon temperature shift during fermentation, accumulating 44% higher biomass and 177% more lycopene than the control strain with wild-type Gal4.	Lycopene	217-225	galactose-responsive transcription factor GAL4	Saccharomyces cerevisiae S288C	5-9
29216442-4	2018	The inhibitory effect of lycopene on 4-AP-evoked glutamate release was markedly reduced in the presence of the Cav2.2 (N-type) and Cav2.1 (P/Q-type) channel blocker omega-conotoxin MVIIC, but was insensitive to the intracellular Ca2+-release inhibitors dantrolene and CGP37157.	Lycopene	25-33	calcium voltage-gated channel subunit alpha1 A	Rattus norvegicus	131-137
29731858-2	2018	In the present study, the role of peroxisome proliferator-activated receptor gamma (PPARgamma) in the effect of lycopene and beta-carotene on the viability of EC109 human esophageal squamous carcinoma cells was investigated.	Lycopene	112-120	peroxisome proliferator activated receptor gamma	Homo sapiens	84-93
29731858-4	2018	The effects of lycopene and beta-carotene on the expression of PPARgamma, p21WAF1/CIP1, cyclin D1 and cyclooxygenase-2 (COX-2) were analyzed by western blotting.	Lycopene	15-23	cyclin dependent kinase inhibitor 1A	Homo sapiens	74-86
29731858-4	2018	The effects of lycopene and beta-carotene on the expression of PPARgamma, p21WAF1/CIP1, cyclin D1 and cyclooxygenase-2 (COX-2) were analyzed by western blotting.	Lycopene	15-23	prostaglandin-endoperoxide synthase 2	Homo sapiens	102-118
29731858-7	2018	Lycopene and beta-carotene treatments upregulated the expression of PPARgamma and p21WAF1/CIP1, and downregulated the expression of cyclin D1 and COX-2.	Lycopene	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	68-77
29731858-7	2018	Lycopene and beta-carotene treatments upregulated the expression of PPARgamma and p21WAF1/CIP1, and downregulated the expression of cyclin D1 and COX-2.	Lycopene	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	90-94
29731858-7	2018	Lycopene and beta-carotene treatments upregulated the expression of PPARgamma and p21WAF1/CIP1, and downregulated the expression of cyclin D1 and COX-2.	Lycopene	0-8	cyclin D1	Homo sapiens	132-141
29731858-7	2018	Lycopene and beta-carotene treatments upregulated the expression of PPARgamma and p21WAF1/CIP1, and downregulated the expression of cyclin D1 and COX-2.	Lycopene	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	146-151
29731858-8	2018	These modulatory effects of the carotenoid treatments were suppressed by GW9662, suggesting that the inhibition of EC109 cell viability by lycopene and beta-carotene involves PPARgamma signaling pathways and the modulation of p21WAF1/CIP1, cyclin D1 and COX-2 expression.	Lycopene	139-147	peroxisome proliferator activated receptor gamma	Homo sapiens	175-184
29731858-8	2018	These modulatory effects of the carotenoid treatments were suppressed by GW9662, suggesting that the inhibition of EC109 cell viability by lycopene and beta-carotene involves PPARgamma signaling pathways and the modulation of p21WAF1/CIP1, cyclin D1 and COX-2 expression.	Lycopene	139-147	cyclin dependent kinase inhibitor 1A	Homo sapiens	226-238
29731858-8	2018	These modulatory effects of the carotenoid treatments were suppressed by GW9662, suggesting that the inhibition of EC109 cell viability by lycopene and beta-carotene involves PPARgamma signaling pathways and the modulation of p21WAF1/CIP1, cyclin D1 and COX-2 expression.	Lycopene	139-147	cyclin D1	Homo sapiens	240-249
29731858-8	2018	These modulatory effects of the carotenoid treatments were suppressed by GW9662, suggesting that the inhibition of EC109 cell viability by lycopene and beta-carotene involves PPARgamma signaling pathways and the modulation of p21WAF1/CIP1, cyclin D1 and COX-2 expression.	Lycopene	139-147	prostaglandin-endoperoxide synthase 2	Homo sapiens	254-259
29643937-9	2018	Transcriptional changes of INO1 gene and CTT1 gene confirmed that endogenous lycopene can decrease oxidative stress and improve intracellular environment.	Lycopene	77-85	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	27-31
29643937-9	2018	Transcriptional changes of INO1 gene and CTT1 gene confirmed that endogenous lycopene can decrease oxidative stress and improve intracellular environment.	Lycopene	77-85	catalase T	Saccharomyces cerevisiae S288C	41-45
29528226-6	2018	Our results indicated that SlMYC2 might be involved in MeJA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels.	Lycopene	179-187	transcription factor MYC2	Solanum lycopersicum	27-33
29805971-7	2018	However, L-PC had superior activity in these terms, presumably due to the presence of lycopene, a powerful antioxidant, in the L-PC-Lycosome structure.	Lycopene	86-94	proprotein convertase subtilisin/kexin type 7	Homo sapiens	9-13
29805971-7	2018	However, L-PC had superior activity in these terms, presumably due to the presence of lycopene, a powerful antioxidant, in the L-PC-Lycosome structure.	Lycopene	86-94	proprotein convertase subtilisin/kexin type 7	Homo sapiens	127-131
29266812-1	2018	SCOPE: Beta-carotene-15,15"-oxygenase (BCO1) and beta-carotene-9",10"-oxygenase (BCO2) metabolize lycopene to biologically active metabolites, which can ameliorate nonalcoholic fatty liver disease (NAFLD).	Lycopene	98-106	beta-carotene oxygenase 1	Mus musculus	39-43
29266812-1	2018	SCOPE: Beta-carotene-15,15"-oxygenase (BCO1) and beta-carotene-9",10"-oxygenase (BCO2) metabolize lycopene to biologically active metabolites, which can ameliorate nonalcoholic fatty liver disease (NAFLD).	Lycopene	98-106	beta-carotene oxygenase 2	Mus musculus	81-85
29475907-8	2018	LPS-stimulated Cox2, Nos2 and Tnfa gene expression was inhibited by 50 muM beta-carotene and lycopene, and by 0.5-1% TBB.	Lycopene	93-101	nitric oxide synthase 2, inducible	Mus musculus	21-25
29475907-8	2018	LPS-stimulated Cox2, Nos2 and Tnfa gene expression was inhibited by 50 muM beta-carotene and lycopene, and by 0.5-1% TBB.	Lycopene	93-101	tumor necrosis factor	Mus musculus	30-34
29475907-7	2018	RESULTS: Hmox1 mRNA, but not Cox2 and Nos2 mRNA, was up-regulated by 100 muM beta-carotene and lycopene, and by 0.125% TBB.	Lycopene	95-103	heme oxygenase 1	Mus musculus	9-14
29903284-5	2018	Finally, to observe lycopene "s activating effect on nuclear-translocation of Nrf2, L02 cells" nuclear protein was extracted to detect Nrf2 protein content, and also, mRNA expression level of Nrf2 target genes HO-1 and NQO1 was assayed to verify this mechanism.	Lycopene	20-28	NFE2 like bZIP transcription factor 2	Homo sapiens	78-82
29475907-8	2018	LPS-stimulated Cox2, Nos2 and Tnfa gene expression was inhibited by 50 muM beta-carotene and lycopene, and by 0.5-1% TBB.	Lycopene	93-101	prostaglandin-endoperoxide synthase 2	Mus musculus	15-19
29195132-7	2018	After intragastric pretreatment with lycopene, inflammatory cytokines were significantly reduced and lycopene also reversed the Abeta1-42 induced up-regulation of TLR4 and NF-kappaB p65 mRNA and protein expressions at the choroid plexus.	Lycopene	37-45	toll-like receptor 4	Rattus norvegicus	163-167
29195132-7	2018	After intragastric pretreatment with lycopene, inflammatory cytokines were significantly reduced and lycopene also reversed the Abeta1-42 induced up-regulation of TLR4 and NF-kappaB p65 mRNA and protein expressions at the choroid plexus.	Lycopene	101-109	toll-like receptor 4	Rattus norvegicus	163-167
29195132-8	2018	These results provided a novel evidence that lycopene significantly improved cognitive deficits and were accompanied by the attenuation of inflammatory injury via blocking the activation of NF-kappaB p65 and TLR4 expressions and production of cytokines, thereby endorsing its usefulness for diminishing beta-amyloid deposition in the hippocampus tissues.	Lycopene	45-53	toll-like receptor 4	Rattus norvegicus	208-212
29629346-9	2018	Molecular analysis of the ovarian tumors revealed that lycopene reduced the expression of NF-kappaB while increasing the expression of nuclear factor erythroid 2 and its major target protein, heme oxygenase 1.	Lycopene	55-63	heme oxygenase 1	Gallus gallus	192-208
29629346-10	2018	In addition, lycopene supplementation decreased the expression of STAT3 by inducing the protein inhibitor of activated STAT3 expression in the ovarian tissues.	Lycopene	13-21	signal transducer and activator of transcription 3	Gallus gallus	66-71
29629346-10	2018	In addition, lycopene supplementation decreased the expression of STAT3 by inducing the protein inhibitor of activated STAT3 expression in the ovarian tissues.	Lycopene	13-21	signal transducer and activator of transcription 3	Gallus gallus	119-124
29903284-5	2018	Finally, to observe lycopene "s activating effect on nuclear-translocation of Nrf2, L02 cells" nuclear protein was extracted to detect Nrf2 protein content, and also, mRNA expression level of Nrf2 target genes HO-1 and NQO1 was assayed to verify this mechanism.	Lycopene	20-28	NAD(P)H quinone dehydrogenase 1	Homo sapiens	219-223
29903284-7	2018	Lycopene also increased nuclear Nrf2 protein content and enhanced the expression of its target genes HO-1 and NQO1.	Lycopene	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	32-36
29903284-7	2018	Lycopene also increased nuclear Nrf2 protein content and enhanced the expression of its target genes HO-1 and NQO1.	Lycopene	0-8	NAD(P)H quinone dehydrogenase 1	Homo sapiens	110-114
29409499-14	2018	Lycopene also plays an anti-injury role by promoting the release of the inhibitory neurotransmitter GABA and 5-HT, which enhances the protective effect, and by upregulating the anti-apoptotic bcl-2.	Lycopene	0-8	BCL2, apoptosis regulator	Rattus norvegicus	192-197
28974442-0	2017	Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-kappaB transcriptional pathway.	Lycopene	19-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115
28703352-2	2018	In tomato (Solanum lycopersicum), we demonstrate additional bottlenecks exist in the poly-cis-transformation of phytoene to lycopene in the context of ripening-induced PSY1 expression and activity and reveal phytoene desaturase (PDS), as a target for manipulation towards elevated lycopene content in maturing tomato fruit.	Lycopene	124-132	phytoene synthase 1, chloroplastic	Solanum lycopersicum	168-172
28703352-2	2018	In tomato (Solanum lycopersicum), we demonstrate additional bottlenecks exist in the poly-cis-transformation of phytoene to lycopene in the context of ripening-induced PSY1 expression and activity and reveal phytoene desaturase (PDS), as a target for manipulation towards elevated lycopene content in maturing tomato fruit.	Lycopene	124-132	15-cis-phytoene desaturase, chloroplastic/chromoplastic	Solanum lycopersicum	229-232
28899454-11	2018	Lutein, beta-carotene, and lycopene LOQs in ready-to-feed nutritionals were estimated to be 0.4, 0.1, and 0.3 microg/100 g, respectively.	Lycopene	27-35	TARBP2 subunit of RISC loading complex	Homo sapiens	36-40
29174038-0	2017	Lycopene amends LPS induced oxidative stress and hypertriglyceridemia via modulating PCSK-9 expression and Apo-CIII mediated lipoprotein lipase activity.	Lycopene	0-8	proprotein convertase subtilisin/kexin type 9	Homo sapiens	85-91
29174038-0	2017	Lycopene amends LPS induced oxidative stress and hypertriglyceridemia via modulating PCSK-9 expression and Apo-CIII mediated lipoprotein lipase activity.	Lycopene	0-8	apolipoprotein C3	Homo sapiens	107-115
29174038-0	2017	Lycopene amends LPS induced oxidative stress and hypertriglyceridemia via modulating PCSK-9 expression and Apo-CIII mediated lipoprotein lipase activity.	Lycopene	0-8	lipoprotein lipase	Homo sapiens	125-143
29174038-1	2017	This study was undertaken to uncover the regulatory role of lycopene in targeting lipopolysaccharide (LPS) induced oxidative stress and inflammatory cascades and subsequent regulation of proprotein convertase subtilisin/kexin type-9 (PCSK-9) expression via sterol regulatory element binding protein-2 (SREBP-2) and hepatocyte nuclear factor-1alpha (HNF-1alpha).	Lycopene	60-68	proprotein convertase subtilisin/kexin type 9	Homo sapiens	187-232
29174038-1	2017	This study was undertaken to uncover the regulatory role of lycopene in targeting lipopolysaccharide (LPS) induced oxidative stress and inflammatory cascades and subsequent regulation of proprotein convertase subtilisin/kexin type-9 (PCSK-9) expression via sterol regulatory element binding protein-2 (SREBP-2) and hepatocyte nuclear factor-1alpha (HNF-1alpha).	Lycopene	60-68	proprotein convertase subtilisin/kexin type 9	Homo sapiens	234-240
29174038-1	2017	This study was undertaken to uncover the regulatory role of lycopene in targeting lipopolysaccharide (LPS) induced oxidative stress and inflammatory cascades and subsequent regulation of proprotein convertase subtilisin/kexin type-9 (PCSK-9) expression via sterol regulatory element binding protein-2 (SREBP-2) and hepatocyte nuclear factor-1alpha (HNF-1alpha).	Lycopene	60-68	sterol regulatory element binding transcription factor 2	Homo sapiens	257-300
29174038-1	2017	This study was undertaken to uncover the regulatory role of lycopene in targeting lipopolysaccharide (LPS) induced oxidative stress and inflammatory cascades and subsequent regulation of proprotein convertase subtilisin/kexin type-9 (PCSK-9) expression via sterol regulatory element binding protein-2 (SREBP-2) and hepatocyte nuclear factor-1alpha (HNF-1alpha).	Lycopene	60-68	sterol regulatory element binding transcription factor 2	Homo sapiens	302-309
29174038-1	2017	This study was undertaken to uncover the regulatory role of lycopene in targeting lipopolysaccharide (LPS) induced oxidative stress and inflammatory cascades and subsequent regulation of proprotein convertase subtilisin/kexin type-9 (PCSK-9) expression via sterol regulatory element binding protein-2 (SREBP-2) and hepatocyte nuclear factor-1alpha (HNF-1alpha).	Lycopene	60-68	HNF1 homeobox A	Homo sapiens	315-347
29174038-1	2017	This study was undertaken to uncover the regulatory role of lycopene in targeting lipopolysaccharide (LPS) induced oxidative stress and inflammatory cascades and subsequent regulation of proprotein convertase subtilisin/kexin type-9 (PCSK-9) expression via sterol regulatory element binding protein-2 (SREBP-2) and hepatocyte nuclear factor-1alpha (HNF-1alpha).	Lycopene	60-68	HNF1 homeobox A	Homo sapiens	349-359
28941679-7	2017	The results from this study provided useful information for producing small-sized lycopene nanodispersions with a narrow PDI and good stability for application in beverage products.	Lycopene	82-90	peptidyl arginine deiminase 1	Homo sapiens	121-124
29046014-7	2018	However, CRY1a positively regulated levels of soluble sugars, phytofluene, phytoene, lycopene, and ss-carotene in the fruits.	Lycopene	85-93	cryptochrome 1	Solanum lycopersicum	9-14
28585698-0	2018	Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway.	Lycopene	0-8	forkhead box O3	Homo sapiens	104-110
28585698-0	2018	Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway.	Lycopene	0-8	CREB regulated transcription coactivator 2	Mus musculus	123-129
28585698-0	2018	Lycopene Protects Keratinocytes Against UVB Radiation-Induced Carcinogenesis via Negative Regulation of FOXO3a Through the mTORC2/AKT Signaling Pathway.	Lycopene	0-8	AKT serine/threonine kinase 1	Homo sapiens	130-133
28585698-3	2018	Herein, we investigated the role of FOXO3a signaling in the anti-cancer effects of lycopene.	Lycopene	83-91	forkhead box O3	Homo sapiens	36-42
28585698-4	2018	Results showed that lycopene pretreatment attenuated UVB-induced cell hyper-proliferation and promoted apoptosis, accompanied by decreased cyclin-dependent kinase 2 (CDK2) and CDK4 complex in both human keratinocytes and SKH-1 hairless mice.	Lycopene	20-28	cyclin dependent kinase 2	Homo sapiens	139-164
28585698-4	2018	Results showed that lycopene pretreatment attenuated UVB-induced cell hyper-proliferation and promoted apoptosis, accompanied by decreased cyclin-dependent kinase 2 (CDK2) and CDK4 complex in both human keratinocytes and SKH-1 hairless mice.	Lycopene	20-28	cyclin dependent kinase 2	Homo sapiens	166-170
28585698-4	2018	Results showed that lycopene pretreatment attenuated UVB-induced cell hyper-proliferation and promoted apoptosis, accompanied by decreased cyclin-dependent kinase 2 (CDK2) and CDK4 complex in both human keratinocytes and SKH-1 hairless mice.	Lycopene	20-28	cyclin dependent kinase 4	Homo sapiens	176-180
28585698-6	2018	Gene ablation of FOXO3a attenuated lycopene-induced decrease in cell hyper-proliferation, CDK2, and CDK4 complex, indicating a critical role of FOXO3a in the lycopene-induced anti-proliferative effect of keratinocytes during UVB irradiation.	Lycopene	35-43	forkhead box O3	Homo sapiens	17-23
28585698-6	2018	Gene ablation of FOXO3a attenuated lycopene-induced decrease in cell hyper-proliferation, CDK2, and CDK4 complex, indicating a critical role of FOXO3a in the lycopene-induced anti-proliferative effect of keratinocytes during UVB irradiation.	Lycopene	35-43	cyclin dependent kinase 2	Homo sapiens	90-94
28585698-6	2018	Gene ablation of FOXO3a attenuated lycopene-induced decrease in cell hyper-proliferation, CDK2, and CDK4 complex, indicating a critical role of FOXO3a in the lycopene-induced anti-proliferative effect of keratinocytes during UVB irradiation.	Lycopene	35-43	cyclin dependent kinase 4	Homo sapiens	100-104
28585698-6	2018	Gene ablation of FOXO3a attenuated lycopene-induced decrease in cell hyper-proliferation, CDK2, and CDK4 complex, indicating a critical role of FOXO3a in the lycopene-induced anti-proliferative effect of keratinocytes during UVB irradiation.	Lycopene	35-43	forkhead box O3	Homo sapiens	144-150
28585698-6	2018	Gene ablation of FOXO3a attenuated lycopene-induced decrease in cell hyper-proliferation, CDK2, and CDK4 complex, indicating a critical role of FOXO3a in the lycopene-induced anti-proliferative effect of keratinocytes during UVB irradiation.	Lycopene	158-166	forkhead box O3	Homo sapiens	17-23
28585698-6	2018	Gene ablation of FOXO3a attenuated lycopene-induced decrease in cell hyper-proliferation, CDK2, and CDK4 complex, indicating a critical role of FOXO3a in the lycopene-induced anti-proliferative effect of keratinocytes during UVB irradiation.	Lycopene	158-166	cyclin dependent kinase 4	Homo sapiens	100-104
28585698-6	2018	Gene ablation of FOXO3a attenuated lycopene-induced decrease in cell hyper-proliferation, CDK2, and CDK4 complex, indicating a critical role of FOXO3a in the lycopene-induced anti-proliferative effect of keratinocytes during UVB irradiation.	Lycopene	158-166	forkhead box O3	Homo sapiens	144-150
28585698-7	2018	Transfection with FOXO3a siRNA inhibited the lycopene-induced increase in cell apoptosis, BAX and cleaved PARP expression.	Lycopene	45-53	forkhead box O3	Homo sapiens	18-24
28585698-7	2018	Transfection with FOXO3a siRNA inhibited the lycopene-induced increase in cell apoptosis, BAX and cleaved PARP expression.	Lycopene	45-53	BCL2 associated X, apoptosis regulator	Homo sapiens	90-93
28585698-7	2018	Transfection with FOXO3a siRNA inhibited the lycopene-induced increase in cell apoptosis, BAX and cleaved PARP expression.	Lycopene	45-53	collagen type XI alpha 2 chain	Homo sapiens	106-110
28585698-8	2018	Moreover, loss of AKT induced further accelerated lycopene-induced FOXO3a dephosphorylation, while loss of mechanistic target of rapamycin complex 2 (mTORC2) by transfection with RICTOR siRNA induced levels of AKT phosphorylation comparable to those obtained with lycopene.	Lycopene	50-58	AKT serine/threonine kinase 1	Homo sapiens	18-21
28585698-8	2018	Moreover, loss of AKT induced further accelerated lycopene-induced FOXO3a dephosphorylation, while loss of mechanistic target of rapamycin complex 2 (mTORC2) by transfection with RICTOR siRNA induced levels of AKT phosphorylation comparable to those obtained with lycopene.	Lycopene	50-58	forkhead box O3	Homo sapiens	67-73
28585698-8	2018	Moreover, loss of AKT induced further accelerated lycopene-induced FOXO3a dephosphorylation, while loss of mechanistic target of rapamycin complex 2 (mTORC2) by transfection with RICTOR siRNA induced levels of AKT phosphorylation comparable to those obtained with lycopene.	Lycopene	50-58	RPTOR independent companion of MTOR complex 2	Homo sapiens	179-185
28585698-8	2018	Moreover, loss of AKT induced further accelerated lycopene-induced FOXO3a dephosphorylation, while loss of mechanistic target of rapamycin complex 2 (mTORC2) by transfection with RICTOR siRNA induced levels of AKT phosphorylation comparable to those obtained with lycopene.	Lycopene	50-58	AKT serine/threonine kinase 1	Homo sapiens	210-213
28585698-8	2018	Moreover, loss of AKT induced further accelerated lycopene-induced FOXO3a dephosphorylation, while loss of mechanistic target of rapamycin complex 2 (mTORC2) by transfection with RICTOR siRNA induced levels of AKT phosphorylation comparable to those obtained with lycopene.	Lycopene	264-272	CREB regulated transcription coactivator 2	Mus musculus	150-156
28585698-8	2018	Moreover, loss of AKT induced further accelerated lycopene-induced FOXO3a dephosphorylation, while loss of mechanistic target of rapamycin complex 2 (mTORC2) by transfection with RICTOR siRNA induced levels of AKT phosphorylation comparable to those obtained with lycopene.	Lycopene	264-272	RPTOR independent companion of MTOR complex 2	Homo sapiens	179-185
28585698-9	2018	In contrast, overexpression of AKT or mTORC2 decreased the effects of lycopene on the expression of FOXO3a as well as AKT phosphorylation, suggesting that lycopene depends on the negative modulation of mTORC2/AKT signaling.	Lycopene	70-78	AKT serine/threonine kinase 1	Homo sapiens	31-34
28585698-9	2018	In contrast, overexpression of AKT or mTORC2 decreased the effects of lycopene on the expression of FOXO3a as well as AKT phosphorylation, suggesting that lycopene depends on the negative modulation of mTORC2/AKT signaling.	Lycopene	70-78	CREB regulated transcription coactivator 2	Mus musculus	38-44
28585698-9	2018	In contrast, overexpression of AKT or mTORC2 decreased the effects of lycopene on the expression of FOXO3a as well as AKT phosphorylation, suggesting that lycopene depends on the negative modulation of mTORC2/AKT signaling.	Lycopene	70-78	forkhead box O3	Homo sapiens	100-106
28585698-9	2018	In contrast, overexpression of AKT or mTORC2 decreased the effects of lycopene on the expression of FOXO3a as well as AKT phosphorylation, suggesting that lycopene depends on the negative modulation of mTORC2/AKT signaling.	Lycopene	70-78	CREB regulated transcription coactivator 2	Mus musculus	202-208
28585698-9	2018	In contrast, overexpression of AKT or mTORC2 decreased the effects of lycopene on the expression of FOXO3a as well as AKT phosphorylation, suggesting that lycopene depends on the negative modulation of mTORC2/AKT signaling.	Lycopene	155-163	AKT serine/threonine kinase 1	Homo sapiens	31-34
28585698-9	2018	In contrast, overexpression of AKT or mTORC2 decreased the effects of lycopene on the expression of FOXO3a as well as AKT phosphorylation, suggesting that lycopene depends on the negative modulation of mTORC2/AKT signaling.	Lycopene	155-163	CREB regulated transcription coactivator 2	Mus musculus	38-44
28585698-10	2018	Taken together, our findings demonstrate that the mTORC2/AKT/FOXO3a axis plays a critical role in the anti-proliferative and pro-apoptotic effects of lycopene in UVB-induced photocarcinogenesis.	Lycopene	150-158	CREB regulated transcription coactivator 2	Mus musculus	50-56
28585698-10	2018	Taken together, our findings demonstrate that the mTORC2/AKT/FOXO3a axis plays a critical role in the anti-proliferative and pro-apoptotic effects of lycopene in UVB-induced photocarcinogenesis.	Lycopene	150-158	AKT serine/threonine kinase 1	Homo sapiens	57-60
28585698-10	2018	Taken together, our findings demonstrate that the mTORC2/AKT/FOXO3a axis plays a critical role in the anti-proliferative and pro-apoptotic effects of lycopene in UVB-induced photocarcinogenesis.	Lycopene	150-158	forkhead box O3	Homo sapiens	61-67
29174038-3	2017	Lycopene treatment down-regulated hepatocyte PCSK-9 expression via down-regulation of HNF-1alpha, whereas, LDL-receptor (LDL-R) was up-regulated by subsequent up-regulation of SREBP-2.	Lycopene	0-8	proprotein convertase subtilisin/kexin type 9	Homo sapiens	45-51
29174038-3	2017	Lycopene treatment down-regulated hepatocyte PCSK-9 expression via down-regulation of HNF-1alpha, whereas, LDL-receptor (LDL-R) was up-regulated by subsequent up-regulation of SREBP-2.	Lycopene	0-8	HNF1 homeobox A	Homo sapiens	86-96
29174038-3	2017	Lycopene treatment down-regulated hepatocyte PCSK-9 expression via down-regulation of HNF-1alpha, whereas, LDL-receptor (LDL-R) was up-regulated by subsequent up-regulation of SREBP-2.	Lycopene	0-8	sterol regulatory element binding transcription factor 2	Homo sapiens	176-183
29174038-4	2017	PPI studies showed that lycopene diminishes the affinity of Apo-CIII to complex with LPL (DeltaG: -917.1 Kcal/mol) resulting in increased LPL functionality and TRLs clearance.	Lycopene	24-32	apolipoprotein C3	Homo sapiens	60-68
29174038-4	2017	PPI studies showed that lycopene diminishes the affinity of Apo-CIII to complex with LPL (DeltaG: -917.1 Kcal/mol) resulting in increased LPL functionality and TRLs clearance.	Lycopene	24-32	lipoprotein lipase	Homo sapiens	85-88
29174038-4	2017	PPI studies showed that lycopene diminishes the affinity of Apo-CIII to complex with LPL (DeltaG: -917.1 Kcal/mol) resulting in increased LPL functionality and TRLs clearance.	Lycopene	24-32	lipoprotein lipase	Homo sapiens	138-141
29174038-5	2017	Moreover, lycopene also ameliorated LPS stimulated oxidative-stress via enhanced total antioxidant and HDL associated PON-1 activity in addition to down-regulate the expression and plasma level of inflammatory mediators.	Lycopene	10-18	paraoxonase 1	Homo sapiens	118-123
29174038-6	2017	Based on above findings, we concluded that lycopene exhibits dual role in targeting LPS induced oxidative stress and hypertriglyceridemia via down-regulation of PCSK-9, making greater no.	Lycopene	43-51	proprotein convertase subtilisin/kexin type 9	Homo sapiens	161-167
28974442-0	2017	Supplementation of lycopene attenuates oxidative stress induced neuroinflammation and cognitive impairment via Nrf2/NF-kappaB transcriptional pathway.	Lycopene	19-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	116-125
28758404-6	2017	The current study was designed to appraise the ability of lycopene to prevent mitochondrial dysfunction during the d-GalN/LPS-induced FHF.	Lycopene	58-66	galanin and GMAP prepropeptide	Rattus norvegicus	117-121
29578200-4	2017	This study was aimed to evaluate the anti-EMT properties of bio-active compounds epigallocatechin gallate (EGCG), curcumin and lycopene as inhibitors of EMT induced by transforming growth factor beta 1 (TGF-beta1) in cultured ARPE-19 cells.	Lycopene	127-135	transforming growth factor beta 1	Homo sapiens	168-201
29578200-4	2017	This study was aimed to evaluate the anti-EMT properties of bio-active compounds epigallocatechin gallate (EGCG), curcumin and lycopene as inhibitors of EMT induced by transforming growth factor beta 1 (TGF-beta1) in cultured ARPE-19 cells.	Lycopene	127-135	transforming growth factor beta 1	Homo sapiens	203-212
28472825-0	2017	Lycopene Improves Insulin Sensitivity through Inhibition of STAT3/Srebp-1c-Mediated Lipid Accumulation and Inflammation in Mice fed a High-Fat Diet.	Lycopene	0-8	signal transducer and activator of transcription 3	Mus musculus	60-65
28472825-0	2017	Lycopene Improves Insulin Sensitivity through Inhibition of STAT3/Srebp-1c-Mediated Lipid Accumulation and Inflammation in Mice fed a High-Fat Diet.	Lycopene	0-8	sterol regulatory element binding transcription factor 1	Mus musculus	66-74
28472825-5	2017	We found that Lycopene notably prevented the increase of IL-1beta, TNFalpha and CRP levels in mice fed HFD.	Lycopene	14-22	interleukin 1 beta	Mus musculus	57-65
28472825-5	2017	We found that Lycopene notably prevented the increase of IL-1beta, TNFalpha and CRP levels in mice fed HFD.	Lycopene	14-22	tumor necrosis factor	Mus musculus	67-75
28472825-5	2017	We found that Lycopene notably prevented the increase of IL-1beta, TNFalpha and CRP levels in mice fed HFD.	Lycopene	14-22	C-reactive protein, pentraxin-related	Mus musculus	80-83
28472825-7	2017	Lycopene suppressed the increase of the expression of Srebp-1c, FAS and ACC-1 in mice fed HFD.	Lycopene	0-8	sterol regulatory element binding transcription factor 1	Mus musculus	54-62
28472825-7	2017	Lycopene suppressed the increase of the expression of Srebp-1c, FAS and ACC-1 in mice fed HFD.	Lycopene	0-8	acetyl-Coenzyme A carboxylase alpha	Mus musculus	72-77
28472825-8	2017	The administration of Lycopene notably prevented the expression and phosphorylation of STAT3 in livers of mice induced by HFD.	Lycopene	22-30	signal transducer and activator of transcription 3	Mus musculus	87-92
28472825-9	2017	The treatment of adenovirus carrying STAT3 significantly suppressed the decrease of Srebp-1c expression induced by Lycopene.	Lycopene	115-123	signal transducer and activator of transcription 3	Mus musculus	37-42
28472825-9	2017	The treatment of adenovirus carrying STAT3 significantly suppressed the decrease of Srebp-1c expression induced by Lycopene.	Lycopene	115-123	sterol regulatory element binding transcription factor 1	Mus musculus	84-92
28472825-11	2017	In conclusion, in the current study, we found that Lycopene prevented STAT3 signaling and inhibited Srebp-1c and downstream gene expression, resulting in inhibition of lipid accumulation, inflammation, insulin resistance and metabolic dysfunction.	Lycopene	51-59	signal transducer and activator of transcription 3	Mus musculus	70-75
28472825-11	2017	In conclusion, in the current study, we found that Lycopene prevented STAT3 signaling and inhibited Srebp-1c and downstream gene expression, resulting in inhibition of lipid accumulation, inflammation, insulin resistance and metabolic dysfunction.	Lycopene	51-59	sterol regulatory element binding transcription factor 1	Mus musculus	100-108
28651168-14	2017	There was an increase in the levels of tumor necrosis factor-alpha, interferon-gamma and interleukin-10 after exposure to CS, and these effects were suppressed by both doses of lycopene.	Lycopene	177-185	tumor necrosis factor	Mus musculus	39-66
28651168-14	2017	There was an increase in the levels of tumor necrosis factor-alpha, interferon-gamma and interleukin-10 after exposure to CS, and these effects were suppressed by both doses of lycopene.	Lycopene	177-185	interferon gamma	Mus musculus	68-84
28651168-14	2017	There was an increase in the levels of tumor necrosis factor-alpha, interferon-gamma and interleukin-10 after exposure to CS, and these effects were suppressed by both doses of lycopene.	Lycopene	177-185	interleukin 10	Mus musculus	89-103
28758404-11	2017	The d-GalN/LPS-induced impairment in ATP production and increased enzyme activities were effectively prevented by the lycopene administration.	Lycopene	118-126	galanin and GMAP prepropeptide	Rattus norvegicus	6-10
28758404-14	2017	The carotenoid lycopene combatted oxidative stress, scavenged free radicals, prevented ROS generation, and inhibited the toxic effects of d-GalN/LPS during FHF.	Lycopene	15-23	galanin and GMAP prepropeptide	Rattus norvegicus	140-144
28689962-0	2017	Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration.	Lycopene	38-46	nuclear factor, erythroid derived 2, like 2	Mus musculus	57-61
28813012-6	2017	We investigated whether lycopene inhibits amyloid-beta-stimulated apoptosis through reducing ROS and inhibiting mitochondrial dysfunction and NF-kappaB-mediated Nucling expression in neuronal SH-SY5Y cells.	Lycopene	24-32	uveal autoantigen with coiled-coil domains and ankyrin repeats	Homo sapiens	161-168
28813012-11	2017	Lycopene inhibited apoptosis by reducing ROS, and by inhibiting mitochondrial dysfunction and NF-kappaB-target gene Nucling expression in neuronal cells.	Lycopene	0-8	uveal autoantigen with coiled-coil domains and ankyrin repeats	Homo sapiens	116-123
28723216-0	2017	Lycopene Inhibits Metastasis of Human Liver Adenocarcinoma SK-Hep-1 Cells by Downregulation of NADPH Oxidase 4 Protein Expression.	Lycopene	0-8	NADPH oxidase 4	Homo sapiens	95-110
28723216-3	2017	However, the role of NOX4 in the anti-metastatic action of lycopene remains unknown.	Lycopene	59-67	NADPH oxidase 4	Homo sapiens	21-25
28723216-5	2017	We showed that lycopene significantly inhibited NOX4 protein expression, with the strongest inhibition of 64.3 +- 10.2% (P &lt; 0.05) at 2.5 muM lycopene.	Lycopene	15-23	NADPH oxidase 4	Homo sapiens	48-52
28723216-6	2017	Lycopene also significantly inhibited NOX4 mRNA expression, NOX activity, and intracellular ROS levels in SK-Hep-1 cells.	Lycopene	0-8	NADPH oxidase 4	Homo sapiens	38-42
28723216-7	2017	We then determined the effects of lycopene on transforming growth factor beta (TGF-beta)-induced metastasis.	Lycopene	34-42	transforming growth factor beta 1	Homo sapiens	46-77
28723216-7	2017	We then determined the effects of lycopene on transforming growth factor beta (TGF-beta)-induced metastasis.	Lycopene	34-42	transforming growth factor beta 1	Homo sapiens	79-87
28723216-9	2017	All these TGF-beta-induced effects were antagonized by the incubation of SK-Hep-1 cells with lycopene (2.5 muM).	Lycopene	93-101	transforming growth factor beta 1	Homo sapiens	10-18
28723216-10	2017	Using transient transfection of siRNA against NOX4, we found that the downregulation of NOX4 could mimic lycopene by inhibiting cell migration and the activities of MMP-9 and MMP-2 during the incubation with or without TGF-beta on SK-Hep-1 cells.	Lycopene	105-113	NADPH oxidase 4	Homo sapiens	46-50
28723216-10	2017	Using transient transfection of siRNA against NOX4, we found that the downregulation of NOX4 could mimic lycopene by inhibiting cell migration and the activities of MMP-9 and MMP-2 during the incubation with or without TGF-beta on SK-Hep-1 cells.	Lycopene	105-113	NADPH oxidase 4	Homo sapiens	88-92
28723216-10	2017	Using transient transfection of siRNA against NOX4, we found that the downregulation of NOX4 could mimic lycopene by inhibiting cell migration and the activities of MMP-9 and MMP-2 during the incubation with or without TGF-beta on SK-Hep-1 cells.	Lycopene	105-113	matrix metallopeptidase 9	Homo sapiens	165-170
28723216-10	2017	Using transient transfection of siRNA against NOX4, we found that the downregulation of NOX4 could mimic lycopene by inhibiting cell migration and the activities of MMP-9 and MMP-2 during the incubation with or without TGF-beta on SK-Hep-1 cells.	Lycopene	105-113	matrix metallopeptidase 2	Homo sapiens	175-180
28723216-10	2017	Using transient transfection of siRNA against NOX4, we found that the downregulation of NOX4 could mimic lycopene by inhibiting cell migration and the activities of MMP-9 and MMP-2 during the incubation with or without TGF-beta on SK-Hep-1 cells.	Lycopene	105-113	transforming growth factor beta 1	Homo sapiens	219-227
28723216-11	2017	The results demonstrate that the downregulation of NOX4 plays a crucial role in the anti-metastatic action of lycopene in SK-Hep-1 cells.	Lycopene	110-118	NADPH oxidase 4	Homo sapiens	51-55
28412198-2	2017	Thus, the current study was premeditated not only to evaluate the role of lycopene in targeting the inhibition of PCSK-9 via modulation of genes involved in cholesterol homeostasis in HFD rats but also to examine a correlation between HFD induced inflammatory cascades and subsequent regulation of PCSK-9 expression.	Lycopene	74-82	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	114-120
28412198-5	2017	The results from our molecular informatics studies confirmed that lycopene, while occupying the active site of PCSK-9 crystal structure, reduces the affinity of PCSK-9 to complex with EGF-A of LDL-R, whereas, atorvastatin makes PCSK-9-EGF-A complex formation more feasible than both of PCSK-9-EGF-A alone and Lycopene-PCSK-9-EGF-A complex.	Lycopene	66-74	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	111-117
28412198-5	2017	The results from our molecular informatics studies confirmed that lycopene, while occupying the active site of PCSK-9 crystal structure, reduces the affinity of PCSK-9 to complex with EGF-A of LDL-R, whereas, atorvastatin makes PCSK-9-EGF-A complex formation more feasible than both of PCSK-9-EGF-A alone and Lycopene-PCSK-9-EGF-A complex.	Lycopene	66-74	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	161-167
28412198-5	2017	The results from our molecular informatics studies confirmed that lycopene, while occupying the active site of PCSK-9 crystal structure, reduces the affinity of PCSK-9 to complex with EGF-A of LDL-R, whereas, atorvastatin makes PCSK-9-EGF-A complex formation more feasible than both of PCSK-9-EGF-A alone and Lycopene-PCSK-9-EGF-A complex.	Lycopene	66-74	low density lipoprotein receptor	Rattus norvegicus	193-198
28412198-5	2017	The results from our molecular informatics studies confirmed that lycopene, while occupying the active site of PCSK-9 crystal structure, reduces the affinity of PCSK-9 to complex with EGF-A of LDL-R, whereas, atorvastatin makes PCSK-9-EGF-A complex formation more feasible than both of PCSK-9-EGF-A alone and Lycopene-PCSK-9-EGF-A complex.	Lycopene	66-74	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	161-167
28412198-5	2017	The results from our molecular informatics studies confirmed that lycopene, while occupying the active site of PCSK-9 crystal structure, reduces the affinity of PCSK-9 to complex with EGF-A of LDL-R, whereas, atorvastatin makes PCSK-9-EGF-A complex formation more feasible than both of PCSK-9-EGF-A alone and Lycopene-PCSK-9-EGF-A complex.	Lycopene	66-74	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	161-167
28412198-5	2017	The results from our molecular informatics studies confirmed that lycopene, while occupying the active site of PCSK-9 crystal structure, reduces the affinity of PCSK-9 to complex with EGF-A of LDL-R, whereas, atorvastatin makes PCSK-9-EGF-A complex formation more feasible than both of PCSK-9-EGF-A alone and Lycopene-PCSK-9-EGF-A complex.	Lycopene	66-74	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	161-167
28412198-5	2017	The results from our molecular informatics studies confirmed that lycopene, while occupying the active site of PCSK-9 crystal structure, reduces the affinity of PCSK-9 to complex with EGF-A of LDL-R, whereas, atorvastatin makes PCSK-9-EGF-A complex formation more feasible than both of PCSK-9-EGF-A alone and Lycopene-PCSK-9-EGF-A complex.	Lycopene	309-317	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	111-117
28412198-5	2017	The results from our molecular informatics studies confirmed that lycopene, while occupying the active site of PCSK-9 crystal structure, reduces the affinity of PCSK-9 to complex with EGF-A of LDL-R, whereas, atorvastatin makes PCSK-9-EGF-A complex formation more feasible than both of PCSK-9-EGF-A alone and Lycopene-PCSK-9-EGF-A complex.	Lycopene	309-317	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	161-167
28412198-5	2017	The results from our molecular informatics studies confirmed that lycopene, while occupying the active site of PCSK-9 crystal structure, reduces the affinity of PCSK-9 to complex with EGF-A of LDL-R, whereas, atorvastatin makes PCSK-9-EGF-A complex formation more feasible than both of PCSK-9-EGF-A alone and Lycopene-PCSK-9-EGF-A complex.	Lycopene	309-317	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	161-167
28412198-5	2017	The results from our molecular informatics studies confirmed that lycopene, while occupying the active site of PCSK-9 crystal structure, reduces the affinity of PCSK-9 to complex with EGF-A of LDL-R, whereas, atorvastatin makes PCSK-9-EGF-A complex formation more feasible than both of PCSK-9-EGF-A alone and Lycopene-PCSK-9-EGF-A complex.	Lycopene	309-317	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	161-167
28412198-5	2017	The results from our molecular informatics studies confirmed that lycopene, while occupying the active site of PCSK-9 crystal structure, reduces the affinity of PCSK-9 to complex with EGF-A of LDL-R, whereas, atorvastatin makes PCSK-9-EGF-A complex formation more feasible than both of PCSK-9-EGF-A alone and Lycopene-PCSK-9-EGF-A complex.	Lycopene	309-317	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	161-167
28412198-6	2017	Based on above results, it can be concluded that lycopene exhibits potent hypolipidemic activities via molecular mechanisms that are either identical (HMGR inhibition) or distinct from that of statins (down-regulation of PCSK-9 mRNA synthesis).	Lycopene	49-57	proprotein convertase subtilisin/kexin type 9	Rattus norvegicus	221-227
28689962-8	2017	Nrf2-controlled genes Ho-1, Nqo-1, and Gclm by qRT-PCR and Nrf2 in the nucleus were upregulated in 661 W cells exposed astaxanthin, adonixanthin, echinenone, and lycopene.	Lycopene	162-170	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
28689962-8	2017	Nrf2-controlled genes Ho-1, Nqo-1, and Gclm by qRT-PCR and Nrf2 in the nucleus were upregulated in 661 W cells exposed astaxanthin, adonixanthin, echinenone, and lycopene.	Lycopene	162-170	glutamate-cysteine ligase, modifier subunit	Mus musculus	39-43
28689962-10	2017	Moreover, pretreatment with adonixanthin or lycopene only before light exposure protected against light-induced cell damage and Nrf2 silencing canceled these effects.	Lycopene	44-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	128-132
28689962-11	2017	These findings indicate that the more potent astaxanthin analogs, adonixanthin and lycopene, protect against light-induced cell damage through not only an anti-oxidative response but also through Nrf2 activation.	Lycopene	83-91	nuclear factor, erythroid derived 2, like 2	Mus musculus	196-200
28440398-0	2017	Lycopene inhibits NF-kappaB activation and adhesion molecule expression through Nrf2-mediated heme oxygenase-1 in endothelial cells.	Lycopene	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84
27884046-6	2017	Administration of rosmarinic acid and lycopene decreased elevated serum creatinine, blood urea nitrogen, renal malondialdehyde and immunoexpression of the proapoptotic protein (Bax), autophagic marker protein (LC3/B), and inducible nitric oxide synthase (iNOS) induced by gentamicin.	Lycopene	38-46	BCL2 associated X, apoptosis regulator	Rattus norvegicus	177-180
27884046-6	2017	Administration of rosmarinic acid and lycopene decreased elevated serum creatinine, blood urea nitrogen, renal malondialdehyde and immunoexpression of the proapoptotic protein (Bax), autophagic marker protein (LC3/B), and inducible nitric oxide synthase (iNOS) induced by gentamicin.	Lycopene	38-46	annexin A3	Rattus norvegicus	210-215
27884046-6	2017	Administration of rosmarinic acid and lycopene decreased elevated serum creatinine, blood urea nitrogen, renal malondialdehyde and immunoexpression of the proapoptotic protein (Bax), autophagic marker protein (LC3/B), and inducible nitric oxide synthase (iNOS) induced by gentamicin.	Lycopene	38-46	nitric oxide synthase 2	Rattus norvegicus	222-253
28670494-7	2017	Immunostaining of tumor and metastatic tissues for Ki67 revealed that lycopene reduced the number of proliferating cancer cells.	Lycopene	70-78	antigen identified by monoclonal antibody Ki 67	Mus musculus	51-55
28670494-8	2017	Lycopene decreased the expression of the ovarian cancer biomarker, CA125.	Lycopene	0-8	mucin 16	Mus musculus	67-72
27406859-2	2017	We tested whether a lycopene-rich tomato intervention could reduce the levels of prostate specific antigen (PSA) in prostate cancer patients.	Lycopene	20-28	kallikrein related peptidase 3	Homo sapiens	108-111
27406859-6	2017	In separate post-hoc analyses, we observed that median PSA-values decreased by 1% in patients with the highest increases in plasma lycopene, selenium and C20:5 n-3 fatty acid, compared to an 8.5% increase in the patients with the lowest increase in lycopene, selenium and C20:5 n-3 fatty acid (p = 0.003).	Lycopene	131-139	kallikrein related peptidase 3	Homo sapiens	55-58
27406859-6	2017	In separate post-hoc analyses, we observed that median PSA-values decreased by 1% in patients with the highest increases in plasma lycopene, selenium and C20:5 n-3 fatty acid, compared to an 8.5% increase in the patients with the lowest increase in lycopene, selenium and C20:5 n-3 fatty acid (p = 0.003).	Lycopene	249-257	kallikrein related peptidase 3	Homo sapiens	55-58
27406859-7	2017	Also, PSA decreased in patients with the highest increase in lycopene alone (p = 0.009).	Lycopene	61-69	kallikrein related peptidase 3	Homo sapiens	6-9
28440398-0	2017	Lycopene inhibits NF-kappaB activation and adhesion molecule expression through Nrf2-mediated heme oxygenase-1 in endothelial cells.	Lycopene	0-8	heme oxygenase 1	Homo sapiens	94-110
28440398-4	2017	We demonstrate that lycopene inhibits the adhesion of tumor necrosis factor alpha (TNFalpha)-stimulated monocytes to endothelial cells and suppresses the expression of intercellular cell adhesion molecule-1 (ICAM-1) at the transcriptional level.	Lycopene	20-28	tumor necrosis factor	Homo sapiens	54-81
28440398-4	2017	We demonstrate that lycopene inhibits the adhesion of tumor necrosis factor alpha (TNFalpha)-stimulated monocytes to endothelial cells and suppresses the expression of intercellular cell adhesion molecule-1 (ICAM-1) at the transcriptional level.	Lycopene	20-28	tumor necrosis factor	Homo sapiens	83-91
28440398-4	2017	We demonstrate that lycopene inhibits the adhesion of tumor necrosis factor alpha (TNFalpha)-stimulated monocytes to endothelial cells and suppresses the expression of intercellular cell adhesion molecule-1 (ICAM-1) at the transcriptional level.	Lycopene	20-28	intercellular adhesion molecule 1	Homo sapiens	168-206
28440398-4	2017	We demonstrate that lycopene inhibits the adhesion of tumor necrosis factor alpha (TNFalpha)-stimulated monocytes to endothelial cells and suppresses the expression of intercellular cell adhesion molecule-1 (ICAM-1) at the transcriptional level.	Lycopene	20-28	intercellular adhesion molecule 1	Homo sapiens	208-214
28440398-5	2017	Moreover, lycopene was found to exert its inhibitory effects by blocking the degradation of the inhibitory protein, IkappaBalpha, following 6 h of pre-treatment.	Lycopene	10-18	NFKB inhibitor alpha	Homo sapiens	116-128
28440398-6	2017	In TNFalpha-stimulated endothelial cells, nuclear factor-kappaB (NF-kappaB) nuclear translocation and transcriptional activity were abolished by up to 12 h of lycopene pre-treatment.	Lycopene	159-167	tumor necrosis factor	Homo sapiens	3-11
28440398-8	2017	Subsequently, lycopene induced nuclear factor-erythroid 2 related factor 2 (Nrf2) activation, leading to the increased expression of downstream of heme oxygenase-1 (HO-1).	Lycopene	14-22	NFE2 like bZIP transcription factor 2	Homo sapiens	31-74
28440398-8	2017	Subsequently, lycopene induced nuclear factor-erythroid 2 related factor 2 (Nrf2) activation, leading to the increased expression of downstream of heme oxygenase-1 (HO-1).	Lycopene	14-22	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
28440398-8	2017	Subsequently, lycopene induced nuclear factor-erythroid 2 related factor 2 (Nrf2) activation, leading to the increased expression of downstream of heme oxygenase-1 (HO-1).	Lycopene	14-22	heme oxygenase 1	Homo sapiens	147-163
28440398-8	2017	Subsequently, lycopene induced nuclear factor-erythroid 2 related factor 2 (Nrf2) activation, leading to the increased expression of downstream of heme oxygenase-1 (HO-1).	Lycopene	14-22	heme oxygenase 1	Homo sapiens	165-169
28440398-9	2017	The use of siRNA targeting HO-1 blocked the inhibitory effects of lycopene on IkappaB degradation and ICAM-1 expression.	Lycopene	66-74	heme oxygenase 1	Homo sapiens	27-31
28440398-9	2017	The use of siRNA targeting HO-1 blocked the inhibitory effects of lycopene on IkappaB degradation and ICAM-1 expression.	Lycopene	66-74	intercellular adhesion molecule 1	Homo sapiens	102-108
28440398-10	2017	The inhibitory effects of lycopene thus appear to be mediated through its induction of Nrf2-mediated HO-1 expression.	Lycopene	26-34	NFE2 like bZIP transcription factor 2	Homo sapiens	87-91
28440398-10	2017	The inhibitory effects of lycopene thus appear to be mediated through its induction of Nrf2-mediated HO-1 expression.	Lycopene	26-34	heme oxygenase 1	Homo sapiens	101-105
28440398-11	2017	Therefore, the findings of the present study indicate that lycopene suppresses the activation of TNFalpha-induced signaling pathways through the upregulation of Nrf2-mediated HO-1 expression.	Lycopene	59-67	tumor necrosis factor	Homo sapiens	97-105
28440398-11	2017	Therefore, the findings of the present study indicate that lycopene suppresses the activation of TNFalpha-induced signaling pathways through the upregulation of Nrf2-mediated HO-1 expression.	Lycopene	59-67	NFE2 like bZIP transcription factor 2	Homo sapiens	161-165
28440398-11	2017	Therefore, the findings of the present study indicate that lycopene suppresses the activation of TNFalpha-induced signaling pathways through the upregulation of Nrf2-mediated HO-1 expression.	Lycopene	59-67	heme oxygenase 1	Homo sapiens	175-179
27928873-0	2017	Lycopene inhibits regulator of calcineurin 1-mediated apoptosis by reducing oxidative stress and down-regulating Nucling in neuronal cells.	Lycopene	0-8	regulator of calcineurin 1	Homo sapiens	18-44
27928873-0	2017	Lycopene inhibits regulator of calcineurin 1-mediated apoptosis by reducing oxidative stress and down-regulating Nucling in neuronal cells.	Lycopene	0-8	uveal autoantigen with coiled-coil domains and ankyrin repeats	Homo sapiens	113-120
27928873-4	2017	The present study is to investigate whether lycopene inhibits apoptosis by reducing ROS levels, NF-kappaB activation, expression of the apoptosis regulator Nucling, cell viability, and indices of apoptosis (cytochrome c release, caspase-3 activation) in RCAN1-overexpressing neuronal cells.	Lycopene	44-52	cytochrome c, somatic	Homo sapiens	207-219
27928873-4	2017	The present study is to investigate whether lycopene inhibits apoptosis by reducing ROS levels, NF-kappaB activation, expression of the apoptosis regulator Nucling, cell viability, and indices of apoptosis (cytochrome c release, caspase-3 activation) in RCAN1-overexpressing neuronal cells.	Lycopene	44-52	caspase 3	Homo sapiens	229-238
27928873-4	2017	The present study is to investigate whether lycopene inhibits apoptosis by reducing ROS levels, NF-kappaB activation, expression of the apoptosis regulator Nucling, cell viability, and indices of apoptosis (cytochrome c release, caspase-3 activation) in RCAN1-overexpressing neuronal cells.	Lycopene	44-52	uveal autoantigen with coiled-coil domains and ankyrin repeats	Homo sapiens	156-163
27928873-4	2017	The present study is to investigate whether lycopene inhibits apoptosis by reducing ROS levels, NF-kappaB activation, expression of the apoptosis regulator Nucling, cell viability, and indices of apoptosis (cytochrome c release, caspase-3 activation) in RCAN1-overexpressing neuronal cells.	Lycopene	44-52	regulator of calcineurin 1	Homo sapiens	254-259
27928873-6	2017	Lycopene decreased intracellular and mitochondrial ROS levels, NF-kappaB activity, and Nucling expression while it reversed decrease in mitochondrial membrane potential, mitochondrial respiration, and glycolytic function in RCAN1-overexpressing cells.	Lycopene	0-8	uveal autoantigen with coiled-coil domains and ankyrin repeats	Homo sapiens	87-94
27928873-6	2017	Lycopene decreased intracellular and mitochondrial ROS levels, NF-kappaB activity, and Nucling expression while it reversed decrease in mitochondrial membrane potential, mitochondrial respiration, and glycolytic function in RCAN1-overexpressing cells.	Lycopene	0-8	regulator of calcineurin 1	Homo sapiens	224-229
28386381-8	2017	RESULTS: In cells treated with lycopene and LPS, the mRNA expression of TNF-alpha, IL-1beta, IL-6, iNOS, and COX-2 were decreased significantly in a dose-dependent manner (P &lt; 0.05).	Lycopene	31-39	tumor necrosis factor	Homo sapiens	72-81
27928873-7	2017	Lycopene inhibited cell death, DNA fragmentation, caspase-3 activation, and cytochrome c release in RCAN1-overexpressing cells.	Lycopene	0-8	caspase 3	Homo sapiens	50-59
27928873-7	2017	Lycopene inhibited cell death, DNA fragmentation, caspase-3 activation, and cytochrome c release in RCAN1-overexpressing cells.	Lycopene	0-8	cytochrome c, somatic	Homo sapiens	76-88
27928873-7	2017	Lycopene inhibited cell death, DNA fragmentation, caspase-3 activation, and cytochrome c release in RCAN1-overexpressing cells.	Lycopene	0-8	regulator of calcineurin 1	Homo sapiens	100-105
27928873-8	2017	CONCLUSION: Lycopene inhibits RCAN1-mediated apoptosis by reducing ROS levels and by inhibiting NF-kappaB activation, Nucling induction, and the increase in apoptotic indices in neuronal cells.	Lycopene	12-20	regulator of calcineurin 1	Homo sapiens	30-35
27928873-8	2017	CONCLUSION: Lycopene inhibits RCAN1-mediated apoptosis by reducing ROS levels and by inhibiting NF-kappaB activation, Nucling induction, and the increase in apoptotic indices in neuronal cells.	Lycopene	12-20	uveal autoantigen with coiled-coil domains and ankyrin repeats	Homo sapiens	118-125
28407181-11	2017	Moreover, lycopene could also upregulate the expression of p53 and Bax mRNAs in MCF-7 cells.	Lycopene	10-18	tumor protein p53	Homo sapiens	59-62
28407181-11	2017	Moreover, lycopene could also upregulate the expression of p53 and Bax mRNAs in MCF-7 cells.	Lycopene	10-18	BCL2 associated X, apoptosis regulator	Homo sapiens	67-70
28407181-12	2017	In conclusion, lycopene inhibits proliferation and facilitates apoptosis of MCF-7 cells in vitro, possibly by regulating the expression of p53 and Bax.	Lycopene	15-23	tumor protein p53	Homo sapiens	139-142
28407181-12	2017	In conclusion, lycopene inhibits proliferation and facilitates apoptosis of MCF-7 cells in vitro, possibly by regulating the expression of p53 and Bax.	Lycopene	15-23	BCL2 associated X, apoptosis regulator	Homo sapiens	147-150
28386381-8	2017	RESULTS: In cells treated with lycopene and LPS, the mRNA expression of TNF-alpha, IL-1beta, IL-6, iNOS, and COX-2 were decreased significantly in a dose-dependent manner (P &lt; 0.05).	Lycopene	31-39	interleukin 1 beta	Homo sapiens	83-91
28386381-8	2017	RESULTS: In cells treated with lycopene and LPS, the mRNA expression of TNF-alpha, IL-1beta, IL-6, iNOS, and COX-2 were decreased significantly in a dose-dependent manner (P &lt; 0.05).	Lycopene	31-39	interleukin 6	Homo sapiens	93-97
28386381-8	2017	RESULTS: In cells treated with lycopene and LPS, the mRNA expression of TNF-alpha, IL-1beta, IL-6, iNOS, and COX-2 were decreased significantly in a dose-dependent manner (P &lt; 0.05).	Lycopene	31-39	nitric oxide synthase 2	Homo sapiens	99-103
28386381-8	2017	RESULTS: In cells treated with lycopene and LPS, the mRNA expression of TNF-alpha, IL-1beta, IL-6, iNOS, and COX-2 were decreased significantly in a dose-dependent manner (P &lt; 0.05).	Lycopene	31-39	prostaglandin-endoperoxide synthase 2	Homo sapiens	109-114
28386381-10	2017	The protein expressions of NF-kappaB and JNK were decreased significantly according to lycopene concertation (P &lt; 0.05).	Lycopene	87-95	nuclear factor kappa B subunit 1	Homo sapiens	27-36
28386381-10	2017	The protein expressions of NF-kappaB and JNK were decreased significantly according to lycopene concertation (P &lt; 0.05).	Lycopene	87-95	mitogen-activated protein kinase 8	Homo sapiens	41-44
28386381-11	2017	CONCLUSIONS: Lycopene restrains NF-kappaB and JNK activation, which causes inflammation, and suppresses the expression of TNF-alpha, IL-1beta, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells.	Lycopene	13-21	nuclear factor kappa B subunit 1	Homo sapiens	32-41
28386381-11	2017	CONCLUSIONS: Lycopene restrains NF-kappaB and JNK activation, which causes inflammation, and suppresses the expression of TNF-alpha, IL-1beta, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells.	Lycopene	13-21	mitogen-activated protein kinase 8	Homo sapiens	46-49
28386381-11	2017	CONCLUSIONS: Lycopene restrains NF-kappaB and JNK activation, which causes inflammation, and suppresses the expression of TNF-alpha, IL-1beta, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells.	Lycopene	13-21	tumor necrosis factor	Homo sapiens	122-131
28386381-11	2017	CONCLUSIONS: Lycopene restrains NF-kappaB and JNK activation, which causes inflammation, and suppresses the expression of TNF-alpha, IL-1beta, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells.	Lycopene	13-21	interleukin 1 beta	Homo sapiens	133-141
28386381-11	2017	CONCLUSIONS: Lycopene restrains NF-kappaB and JNK activation, which causes inflammation, and suppresses the expression of TNF-alpha, IL-1beta, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells.	Lycopene	13-21	interleukin 6	Homo sapiens	143-147
28386381-11	2017	CONCLUSIONS: Lycopene restrains NF-kappaB and JNK activation, which causes inflammation, and suppresses the expression of TNF-alpha, IL-1beta, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells.	Lycopene	13-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	149-154
28386381-11	2017	CONCLUSIONS: Lycopene restrains NF-kappaB and JNK activation, which causes inflammation, and suppresses the expression of TNF-alpha, IL-1beta, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells.	Lycopene	13-21	nitric oxide synthase 2	Homo sapiens	160-164
28345329-0	2017	Lycopene Extracts from Different Tomato-Based Food Products Induce Apoptosis in Cultured Human Primary Prostate Cancer Cells and Regulate TP53, Bax and Bcl-2 Transcript Expression Carotenoids are the main tomato components, especially lycopene.	Lycopene	0-8	tumor protein p53	Homo sapiens	138-142
28345329-0	2017	Lycopene Extracts from Different Tomato-Based Food Products Induce Apoptosis in Cultured Human Primary Prostate Cancer Cells and Regulate TP53, Bax and Bcl-2 Transcript Expression Carotenoids are the main tomato components, especially lycopene.	Lycopene	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	144-147
28345329-0	2017	Lycopene Extracts from Different Tomato-Based Food Products Induce Apoptosis in Cultured Human Primary Prostate Cancer Cells and Regulate TP53, Bax and Bcl-2 Transcript Expression Carotenoids are the main tomato components, especially lycopene.	Lycopene	0-8	BCL2 apoptosis regulator	Homo sapiens	152-157
28345329-5	2017	Using real time PCR assay, we found that lycopene promotedan upregulation of TP53 and Bax transcript expression and also downregulation of Bcl-2 expression in PCa cells.	Lycopene	41-49	tumor protein p53	Homo sapiens	77-81
28345329-5	2017	Using real time PCR assay, we found that lycopene promotedan upregulation of TP53 and Bax transcript expression and also downregulation of Bcl-2 expression in PCa cells.	Lycopene	41-49	BCL2 associated X, apoptosis regulator	Homo sapiens	86-89
28345329-5	2017	Using real time PCR assay, we found that lycopene promotedan upregulation of TP53 and Bax transcript expression and also downregulation of Bcl-2 expression in PCa cells.	Lycopene	41-49	BCL2 apoptosis regulator	Homo sapiens	139-144
27989599-6	2017	Lycopene improved hepatotoxicity acting as an antioxidant, reduced GSSG and regulated tGSH and CAT levels, reduced oxidative damage primarily by decreasing protein carbonylation, promoted the downregulation of MMP-2 and reduced areas of necrosis improving the general appearance of the lesion in C57BL/6 mice.	Lycopene	0-8	catalase	Mus musculus	95-98
27807077-0	2017	beta-Carotene 9",10" Oxygenase Modulates the Anticancer Activity of Dietary Tomato or Lycopene on Prostate Carcinogenesis in the TRAMP Model.	Lycopene	86-94	aquaporin PIP1-5	Solanum lycopersicum	129-134
27807077-4	2017	Both tomato- and lycopene-fed TRAMP:Bco2-/- mice had significantly greater serum concentrations of total, 5-cis, other cis, and all-trans lycopene than TRAMP:Bco2+/+ mice.	Lycopene	17-25	aquaporin PIP1-5	Solanum lycopersicum	30-35
27807077-4	2017	Both tomato- and lycopene-fed TRAMP:Bco2-/- mice had significantly greater serum concentrations of total, 5-cis, other cis, and all-trans lycopene than TRAMP:Bco2+/+ mice.	Lycopene	17-25	beta-carotene oxygenase 2	Mus musculus	36-40
27807077-4	2017	Both tomato- and lycopene-fed TRAMP:Bco2-/- mice had significantly greater serum concentrations of total, 5-cis, other cis, and all-trans lycopene than TRAMP:Bco2+/+ mice.	Lycopene	17-25	tumor necrosis factor receptor superfamily, member 25	Mus musculus	152-157
27807077-4	2017	Both tomato- and lycopene-fed TRAMP:Bco2-/- mice had significantly greater serum concentrations of total, 5-cis, other cis, and all-trans lycopene than TRAMP:Bco2+/+ mice.	Lycopene	17-25	beta-carotene oxygenase 2	Mus musculus	158-162
27807077-7	2017	Overall, dietary tomato and lycopene inhibited the progression of prostate cancer in TRAMP in a Bco2 genotype-specific manner, potentially implicating the anticancer activity of lycopene cleavage products.	Lycopene	28-36	aquaporin PIP1-5	Solanum lycopersicum	85-90
27807077-7	2017	Overall, dietary tomato and lycopene inhibited the progression of prostate cancer in TRAMP in a Bco2 genotype-specific manner, potentially implicating the anticancer activity of lycopene cleavage products.	Lycopene	28-36	beta-carotene oxygenase 2	Mus musculus	96-100
27989599-6	2017	Lycopene improved hepatotoxicity acting as an antioxidant, reduced GSSG and regulated tGSH and CAT levels, reduced oxidative damage primarily by decreasing protein carbonylation, promoted the downregulation of MMP-2 and reduced areas of necrosis improving the general appearance of the lesion in C57BL/6 mice.	Lycopene	0-8	matrix metallopeptidase 2	Mus musculus	210-215
27973616-7	2016	The relative expression level of 28 genes covering ripening-associated transcription factors, ethylene biosynthesis, ethylene signal pathway, chlorophyll binding proteins, lycopene and aroma biosynthesis, and defense pathway, showed that SlEIN2 influences ripening inhibitor (RIN) in a feedback loop, thus controlling the expression of several other genes.	Lycopene	172-180	ethylene signaling protein	Solanum lycopersicum	238-244
28656152-0	2017	The Effects of Lycopene and Insulin on Histological Changes and the Expression Level of Bcl-2 Family Genes in the Hippocampus of Streptozotocin-Induced Diabetic Rats.	Lycopene	15-23	BCL2, apoptosis regulator	Rattus norvegicus	88-93
28656152-1	2017	The aim of this study was to evaluate the effects of antioxidants lycopene and insulin on histological changes and expression of Bcl-2 family genes in the hippocampus of streptozotocin-induced type 1 diabetic rats.	Lycopene	66-74	BCL2, apoptosis regulator	Rattus norvegicus	129-134
28656152-5	2017	Furthermore, insulin and lycopene alone or together reduced the expression of Bax, but increased Bcl-2 and Bcl-xL levels in DI, DL, and DIL rats, especially when compared to group D (p &lt; 0.001).	Lycopene	25-33	BCL2 associated X, apoptosis regulator	Rattus norvegicus	78-81
28656152-5	2017	Furthermore, insulin and lycopene alone or together reduced the expression of Bax, but increased Bcl-2 and Bcl-xL levels in DI, DL, and DIL rats, especially when compared to group D (p &lt; 0.001).	Lycopene	25-33	BCL2, apoptosis regulator	Rattus norvegicus	97-102
28656152-5	2017	Furthermore, insulin and lycopene alone or together reduced the expression of Bax, but increased Bcl-2 and Bcl-xL levels in DI, DL, and DIL rats, especially when compared to group D (p &lt; 0.001).	Lycopene	25-33	Bcl2-like 1	Rattus norvegicus	107-113
27973616-9	2016	Silencing SlEIN2 ultimately results in lycopene biosynthesis inhibition, which is the reason why tomato does not turn red, and this gene also affects the expression of several defense-associated genes.	Lycopene	39-47	ethylene signaling protein	Solanum lycopersicum	10-16
27990087-14	2016	The MDA level and the activities of CAT, GPx, SOD, and GST were significantly lower in the furan + lycopene group than in the furan group (p&lt;0.05).	Lycopene	99-107	catalase	Rattus norvegicus	36-39
28028366-6	2016	RESULTS: A significant decrease was observed in the levels of serum AST (2.07-fold), ALT (2.95-fold), and the blood lipid TG (2.34-fold) and TC (1.66-fold) in the dose of 20 mg/kg Ly-treated rats (P &lt; 0.01), compared to the model group.	Lycopene	180-182	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	68-71
27631138-5	2016	Results showed that Sarcandra glabra and lycopene could significantly ameliorate LPS-induced histopathological injuries, improve the anti-oxidative activities of rats, decrease the levels of TNF-alpha and IL-6, suppress the activations of MAPK and transcription factor NF-kappaB and reverse the disturbed metabolism towards the normal status.	Lycopene	41-49	tumor necrosis factor	Rattus norvegicus	191-200
27631138-5	2016	Results showed that Sarcandra glabra and lycopene could significantly ameliorate LPS-induced histopathological injuries, improve the anti-oxidative activities of rats, decrease the levels of TNF-alpha and IL-6, suppress the activations of MAPK and transcription factor NF-kappaB and reverse the disturbed metabolism towards the normal status.	Lycopene	41-49	interleukin 6	Rattus norvegicus	205-209
27678388-0	2016	Efficacy of lycopene on modulation of renal antioxidant enzymes, ACE and ACE gene expression in hyperlipidaemic rats.	Lycopene	12-20	angiotensin I converting enzyme	Rattus norvegicus	65-68
27694342-7	2016	An isobaric tags for relative and absolute quantification-based quantitative proteomic analysis further indicated that the abundance of a set of proteins involved in fruit ripening was altered by suppressing SlVIF expression, including proteins associated with lycopene generation and ethylene synthesis.	Lycopene	261-269	vacuolar invertase inhibitor	Solanum lycopersicum	208-213
27406826-0	2016	Mitochondrial beta-Carotene 9",10" Oxygenase Modulates Prostate Cancer Growth via NF-kappaB Inhibition: A Lycopene-Independent Function.	Lycopene	106-114	beta-carotene oxygenase 2	Homo sapiens	14-44
27406826-0	2016	Mitochondrial beta-Carotene 9",10" Oxygenase Modulates Prostate Cancer Growth via NF-kappaB Inhibition: A Lycopene-Independent Function.	Lycopene	106-114	nuclear factor kappa B subunit 1	Homo sapiens	82-91
27406826-2	2016	The enzyme beta-carotene 9",10"-oxygenase (BCO2), which catalyzes asymmetric cleavage of several carotenoids, is the principal regulator of lycopene metabolism, but the range of BCO2 biological functions is incompletely understood.	Lycopene	140-148	beta-carotene oxygenase 2	Homo sapiens	11-41
27406826-2	2016	The enzyme beta-carotene 9",10"-oxygenase (BCO2), which catalyzes asymmetric cleavage of several carotenoids, is the principal regulator of lycopene metabolism, but the range of BCO2 biological functions is incompletely understood.	Lycopene	140-148	beta-carotene oxygenase 2	Homo sapiens	43-47
27406826-6	2016	Treatment with lycopene or its metabolite, apo-10-lycopenal, also increased bco2 expression and reduced cell proliferation in androgen-sensitive cell lines, but lycopene neither altered bco2 expression nor cell growth in androgen-resistant cells.	Lycopene	15-23	beta-carotene oxygenase 2	Homo sapiens	76-80
27406826-10	2016	Moreover, these findings describe previously unanticipated functions of BCO2 that are independent of its enzymatic role in lycopene metabolism.	Lycopene	123-131	beta-carotene oxygenase 2	Homo sapiens	72-76
27678388-0	2016	Efficacy of lycopene on modulation of renal antioxidant enzymes, ACE and ACE gene expression in hyperlipidaemic rats.	Lycopene	12-20	angiotensin I converting enzyme	Rattus norvegicus	73-76
27678388-1	2016	INTRODUCTION: We aimed to evaluate the efficacy of lycopene on renal tissue antioxidant enzymes and angiotensin converting enzyme (ACE) gene expression and serum activity in diet-induced hyperlipidaemia.	Lycopene	51-59	angiotensin I converting enzyme	Rattus norvegicus	100-129
27678388-1	2016	INTRODUCTION: We aimed to evaluate the efficacy of lycopene on renal tissue antioxidant enzymes and angiotensin converting enzyme (ACE) gene expression and serum activity in diet-induced hyperlipidaemia.	Lycopene	51-59	angiotensin I converting enzyme	Rattus norvegicus	131-134
27678388-6	2016	Lycopene supplementation significantly decreased plasma urea and creatinine, serum ACE, renal tissue malonyldialdehyde level and C-reactive protein level, while it increased tissue antioxidant enzymes level and total protein.	Lycopene	0-8	angiotensin I converting enzyme	Rattus norvegicus	83-86
27678388-6	2016	Lycopene supplementation significantly decreased plasma urea and creatinine, serum ACE, renal tissue malonyldialdehyde level and C-reactive protein level, while it increased tissue antioxidant enzymes level and total protein.	Lycopene	0-8	C-reactive protein	Rattus norvegicus	129-147
27678388-8	2016	CONCLUSIONS: This finding suggests that supplementation of lycopene is effective for renal antioxidant enzymes, ACE gene expression and ACE serum level in hyperlipidaemic rats.	Lycopene	59-67	angiotensin I converting enzyme	Rattus norvegicus	112-115
27678388-8	2016	CONCLUSIONS: This finding suggests that supplementation of lycopene is effective for renal antioxidant enzymes, ACE gene expression and ACE serum level in hyperlipidaemic rats.	Lycopene	59-67	angiotensin I converting enzyme	Rattus norvegicus	136-139
27609268-0	2016	Depression-like behaviors and heme oxygenase-1 are regulated by Lycopene in lipopolysaccharide-induced neuroinflammation.	Lycopene	64-72	heme oxygenase 1	Homo sapiens	30-46
27609268-9	2016	Moreover, lycopene relieved neuronal cell injury in hippocampal CA1 regions.	Lycopene	10-18	carbonic anhydrase 1	Homo sapiens	64-67
27609268-10	2016	Furthermore, lycopene decreased LPS-induced expression of IL-1beta and HO-1 in the hippocampus together with decreasing level of IL-6 and TNF-alpha in the plasma.	Lycopene	13-21	interleukin 1 beta	Homo sapiens	58-66
27609268-10	2016	Furthermore, lycopene decreased LPS-induced expression of IL-1beta and HO-1 in the hippocampus together with decreasing level of IL-6 and TNF-alpha in the plasma.	Lycopene	13-21	heme oxygenase 1	Homo sapiens	71-75
27609268-10	2016	Furthermore, lycopene decreased LPS-induced expression of IL-1beta and HO-1 in the hippocampus together with decreasing level of IL-6 and TNF-alpha in the plasma.	Lycopene	13-21	interleukin 6	Homo sapiens	129-133
27609268-10	2016	Furthermore, lycopene decreased LPS-induced expression of IL-1beta and HO-1 in the hippocampus together with decreasing level of IL-6 and TNF-alpha in the plasma.	Lycopene	13-21	tumor necrosis factor	Homo sapiens	138-147
27609268-11	2016	Taken together, these results suggest that lycopene can attenuate LPS-induced inflammation and depression-like behaviors, which may be involved in regulating HO-1 in the hippocampus.	Lycopene	43-51	heme oxygenase 1	Homo sapiens	158-162
27357536-10	2016	The expression of the proinflammatory factors TNF-alpha and NF-kB increased markedly 48 h after SCI, and their upregulation was significantly attenuated by lycopene treatment.	Lycopene	156-164	tumor necrosis factor	Mus musculus	46-55
27357536-11	2016	The expression of molecules that protect tight junctions, zonula occluden-1 and claudin-5, was upregulated by lycopene treatment after SCI.	Lycopene	110-118	claudin 5	Mus musculus	80-89
27582593-14	2016	Treatment with sodium valproate and lycopene significantly restored the seizure score, latency, thiobarbituric acid reactive substance, reduced glutathione, catalase, superoxide dismutase, and gamma-aminobutyric acid levels near to normal compared to pentylenetetrazol.	Lycopene	36-44	catalase	Mus musculus	157-165
27143479-8	2016	In further contrast to BCO1, purified recombinant chicken BCO2 also catalyzes the oxidative cleavage of 9-cis-beta-carotene and the non-provitamin A carotenoids zeaxanthin and lutein, and is inactive with all-trans-lycopene and beta-apocarotenoids.	Lycopene	205-223	beta-carotene oxygenase 2	Gallus gallus	58-62
26548547-1	2016	This study initially aimed to depict the molecular rationale evolving the role of lycopene in inhibiting the enzymatic activity of beta-hydroxy-beta-methylglutaryl-CoA (HMG-CoA) reductase via in vitro and in silico analysis.	Lycopene	82-90	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	131-187
27583358-0	2016	Plasma Lycopene Is Associated with Pizza and Pasta Consumption in Middle-Aged and Older African American and White Adults in the Southeastern USA in a Cross-Sectional Study.	Lycopene	7-15	solute carrier family 45 member 1	Homo sapiens	45-50
27583358-11	2016	CONCLUSIONS: In the SCCS population, pizza and pasta were the main sources of dietary lycopene and their intake was associated with plasma lycopene concentration.	Lycopene	86-94	solute carrier family 45 member 1	Homo sapiens	47-52
27583358-11	2016	CONCLUSIONS: In the SCCS population, pizza and pasta were the main sources of dietary lycopene and their intake was associated with plasma lycopene concentration.	Lycopene	139-147	solute carrier family 45 member 1	Homo sapiens	47-52
27102619-0	2016	Lycopene ameliorates atrazine-induced oxidative damage in adrenal cortex of male rats by activation of the Nrf2/HO-1 pathway.	Lycopene	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	107-111
27102619-0	2016	Lycopene ameliorates atrazine-induced oxidative damage in adrenal cortex of male rats by activation of the Nrf2/HO-1 pathway.	Lycopene	0-8	heme oxygenase 1	Rattus norvegicus	112-116
27102619-11	2016	These effects may be attributed to the antioxidative property of lycopene and its ability to activate the Nrf2/HO-1 pathway.	Lycopene	65-73	NFE2 like bZIP transcription factor 2	Rattus norvegicus	106-110
27102619-11	2016	These effects may be attributed to the antioxidative property of lycopene and its ability to activate the Nrf2/HO-1 pathway.	Lycopene	65-73	heme oxygenase 1	Rattus norvegicus	111-115
28852735-5	2016	Western blotting showed that Lycopene significantly enhanced LC3-I, p-ERK proteins expression.	Lycopene	29-37	mitogen-activated protein kinase 1	Homo sapiens	70-73
28852735-8	2016	CONCLUSION: Lycopene treatment inhibited HGC-27 cells growth by activating ERK.	Lycopene	12-20	mitogen-activated protein kinase 1	Homo sapiens	75-78
26779636-0	2016	Lycopene acts through inhibition of IkappaB kinase to suppress NF-kappaB signaling in human prostate and breast cancer cells.	Lycopene	0-8	nuclear factor kappa B subunit 1	Homo sapiens	63-72
26779636-1	2016	We studied the effect of the potent dietary antioxidant lycopene on multiple points along the nuclear factor kappa B (NF-kappaB) signaling pathway in prostate and breast cancer cells.	Lycopene	56-64	nuclear factor kappa B subunit 1	Homo sapiens	94-116
26779636-1	2016	We studied the effect of the potent dietary antioxidant lycopene on multiple points along the nuclear factor kappa B (NF-kappaB) signaling pathway in prostate and breast cancer cells.	Lycopene	56-64	nuclear factor kappa B subunit 1	Homo sapiens	118-127
26779636-4	2016	Furthermore, the same degree of inhibition by lycopene was observed for NF-kappaB transcriptional activity, as determined by reporter gene assay.	Lycopene	46-54	nuclear factor kappa B subunit 1	Homo sapiens	72-81
26779636-5	2016	Concomitant with this, immunofluorescence staining of lycopene-treated cells showed a significant suppression (&gt;=25 %) of TNF-induced NF-kappaB p65 subunit nuclear translocation.	Lycopene	54-62	tumor necrosis factor	Homo sapiens	125-128
26779636-5	2016	Concomitant with this, immunofluorescence staining of lycopene-treated cells showed a significant suppression (&gt;=25 %) of TNF-induced NF-kappaB p65 subunit nuclear translocation.	Lycopene	54-62	nuclear factor kappa B subunit 1	Homo sapiens	137-146
26779636-6	2016	Further probing of lycopene"s effects on upstream elements of the NF-kappaB pathway showed a 25 % inhibition of both activity of recombinant IkappaB kinase beta (IKKbeta) kinase in a cell-free in vitro assay, as well as activity of IKKbeta immunoprecipitated from MDA-MB-231 cells treated with lycopene.	Lycopene	19-27	nuclear factor kappa B subunit 1	Homo sapiens	66-75
26779636-6	2016	Further probing of lycopene"s effects on upstream elements of the NF-kappaB pathway showed a 25 % inhibition of both activity of recombinant IkappaB kinase beta (IKKbeta) kinase in a cell-free in vitro assay, as well as activity of IKKbeta immunoprecipitated from MDA-MB-231 cells treated with lycopene.	Lycopene	19-27	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	141-160
26779636-6	2016	Further probing of lycopene"s effects on upstream elements of the NF-kappaB pathway showed a 25 % inhibition of both activity of recombinant IkappaB kinase beta (IKKbeta) kinase in a cell-free in vitro assay, as well as activity of IKKbeta immunoprecipitated from MDA-MB-231 cells treated with lycopene.	Lycopene	19-27	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	162-169
26779636-6	2016	Further probing of lycopene"s effects on upstream elements of the NF-kappaB pathway showed a 25 % inhibition of both activity of recombinant IkappaB kinase beta (IKKbeta) kinase in a cell-free in vitro assay, as well as activity of IKKbeta immunoprecipitated from MDA-MB-231 cells treated with lycopene.	Lycopene	19-27	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	232-239
26779636-6	2016	Further probing of lycopene"s effects on upstream elements of the NF-kappaB pathway showed a 25 % inhibition of both activity of recombinant IkappaB kinase beta (IKKbeta) kinase in a cell-free in vitro assay, as well as activity of IKKbeta immunoprecipitated from MDA-MB-231 cells treated with lycopene.	Lycopene	294-302	nuclear factor kappa B subunit 1	Homo sapiens	66-75
26779636-6	2016	Further probing of lycopene"s effects on upstream elements of the NF-kappaB pathway showed a 25 % inhibition of both activity of recombinant IkappaB kinase beta (IKKbeta) kinase in a cell-free in vitro assay, as well as activity of IKKbeta immunoprecipitated from MDA-MB-231 cells treated with lycopene.	Lycopene	294-302	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	141-160
26779636-6	2016	Further probing of lycopene"s effects on upstream elements of the NF-kappaB pathway showed a 25 % inhibition of both activity of recombinant IkappaB kinase beta (IKKbeta) kinase in a cell-free in vitro assay, as well as activity of IKKbeta immunoprecipitated from MDA-MB-231 cells treated with lycopene.	Lycopene	294-302	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	162-169
26779636-7	2016	In conclusion, the anticancer properties of lycopene may occur through inhibition of the NF-kappaB signaling pathway, beginning at the early stage of cytoplasmic IKK kinase activity, which then leads to reduced NF-kappaB-responsive gene regulation.	Lycopene	44-52	nuclear factor kappa B subunit 1	Homo sapiens	89-98
26779636-7	2016	In conclusion, the anticancer properties of lycopene may occur through inhibition of the NF-kappaB signaling pathway, beginning at the early stage of cytoplasmic IKK kinase activity, which then leads to reduced NF-kappaB-responsive gene regulation.	Lycopene	44-52	nuclear factor kappa B subunit 1	Homo sapiens	211-220
27155396-0	2016	Lycopene inhibits ICAM-1 expression and NF-kappaB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells.	Lycopene	0-8	intercellular adhesion molecule 1	Homo sapiens	18-24
27155396-0	2016	Lycopene inhibits ICAM-1 expression and NF-kappaB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells.	Lycopene	0-8	nuclear factor kappa B subunit 1	Homo sapiens	40-49
27155396-16	2016	SIGNIFICANCE: The Nrf2-regulated antioxidant property plays a pivotal role in the anti-inflammatory mechanism underlying the inhibition of NF-kappaB activation in lycopene-treated ARPE-19 cells.	Lycopene	163-171	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
27197028-5	2016	The current study evaluated whether the antinociceptive effect of lycopene is mediated through the modulation of Cx43 expression in spinal astrocytes.	Lycopene	66-74	gap junction protein, alpha 1	Mus musculus	113-117
27155396-0	2016	Lycopene inhibits ICAM-1 expression and NF-kappaB activation by Nrf2-regulated cell redox state in human retinal pigment epithelial cells.	Lycopene	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	64-68
27197028-6	2016	MAIN METHODS: The effect of lycopene on Cx43 expression was examined in cultured rat spinal astrocytes.	Lycopene	28-36	gap junction protein, alpha 1	Rattus norvegicus	40-44
27155396-16	2016	SIGNIFICANCE: The Nrf2-regulated antioxidant property plays a pivotal role in the anti-inflammatory mechanism underlying the inhibition of NF-kappaB activation in lycopene-treated ARPE-19 cells.	Lycopene	163-171	nuclear factor kappa B subunit 1	Homo sapiens	139-148
27155396-9	2016	KEY FINDINGS: Lycopene could reduce TNF-alpha-induced monocyte adhesion and H2O2- induced cell damage in RPE cells.	Lycopene	14-22	tumor necrosis factor	Homo sapiens	36-45
27197028-7	2016	The effect of intrathecal lycopene on Cx43 expression and neuropathic pain were evaluated in mice with partial sciatic nerve ligation (PSNL).	Lycopene	26-34	gap junction protein, alpha 1	Mus musculus	38-42
27155396-10	2016	Furthermore, lycopene inhibits ICAM-1 expression and abolishes NF-kappaB activation for up to 12h in TNFalpha-treated RPE cells.	Lycopene	13-21	intercellular adhesion molecule 1	Homo sapiens	31-37
27197028-8	2016	KEY FINDINGS: Treatment of cultured rat spinal astrocytes with lycopene reversed TNF-induced downregulation of Cx43 protein expression through a transcription-independent mechanism.	Lycopene	63-71	tumor necrosis factor	Rattus norvegicus	81-84
27197028-8	2016	KEY FINDINGS: Treatment of cultured rat spinal astrocytes with lycopene reversed TNF-induced downregulation of Cx43 protein expression through a transcription-independent mechanism.	Lycopene	63-71	gap junction protein, alpha 1	Rattus norvegicus	111-115
27155396-10	2016	Furthermore, lycopene inhibits ICAM-1 expression and abolishes NF-kappaB activation for up to 12h in TNFalpha-treated RPE cells.	Lycopene	13-21	nuclear factor kappa B subunit 1	Homo sapiens	63-72
27197028-10	2016	In addition, repeated, but not single, intrathecal treatment with lycopene of mice with a partial sciatic nerve ligation significantly prevented not only the downregulation of Cx43 expression in spinal dorsal horn but mechanical hypersensitivity as well.	Lycopene	66-74	gap junction protein, alpha 1	Mus musculus	176-180
27155396-10	2016	Furthermore, lycopene inhibits ICAM-1 expression and abolishes NF-kappaB activation for up to 12h in TNFalpha-treated RPE cells.	Lycopene	13-21	tumor necrosis factor	Homo sapiens	101-109
27197028-11	2016	SIGNIFICANCE: The current findings suggest a significant spinal mechanism that mediates the analgesic effect of lycopene, through the restoration of normal spinal Cx43 expression.	Lycopene	112-120	gap junction protein, alpha 1	Mus musculus	163-167
27155396-11	2016	Lycopene upregulates Nrf2 levels in nuclear extracts and increases the transactivity of antioxidant response elements.	Lycopene	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
27155396-12	2016	The use of Nrf2 siRNA blocks the inhibitory effect of lycopene in TNF-alpha-induced ICAM-1 expression and NF-kappaB activation.	Lycopene	54-62	NFE2 like bZIP transcription factor 2	Homo sapiens	11-15
27155396-12	2016	The use of Nrf2 siRNA blocks the inhibitory effect of lycopene in TNF-alpha-induced ICAM-1 expression and NF-kappaB activation.	Lycopene	54-62	tumor necrosis factor	Homo sapiens	66-75
27155396-12	2016	The use of Nrf2 siRNA blocks the inhibitory effect of lycopene in TNF-alpha-induced ICAM-1 expression and NF-kappaB activation.	Lycopene	54-62	intercellular adhesion molecule 1	Homo sapiens	84-90
27155396-14	2016	We found that lycopene increases intracellular GSH levels and GCL expression.	Lycopene	14-22	glutamate-cysteine ligase catalytic subunit	Homo sapiens	62-65
27155396-15	2016	Following lycopene treatment, TNF-alpha-induced ROS production was abolished.	Lycopene	10-18	tumor necrosis factor	Homo sapiens	30-39
26816095-6	2016	Additionally, lycopene ameliorated Abeta-induced mitochondrial morphological alteration, opening of the mitochondrial permeability transition pores and the consequent cytochrome c release.	Lycopene	14-22	amyloid beta precursor protein	Rattus norvegicus	35-40
27283141-7	2016	alpha-Carotene, beta-carotene, lutein/zeaxanthin, and lycopene showed a protective effect on ER-/PR+ or ER-/PR- breast cancer.	Lycopene	54-62	estrogen receptor 1	Homo sapiens	93-95
27283141-7	2016	alpha-Carotene, beta-carotene, lutein/zeaxanthin, and lycopene showed a protective effect on ER-/PR+ or ER-/PR- breast cancer.	Lycopene	54-62	progesterone receptor	Homo sapiens	97-99
27283141-7	2016	alpha-Carotene, beta-carotene, lutein/zeaxanthin, and lycopene showed a protective effect on ER-/PR+ or ER-/PR- breast cancer.	Lycopene	54-62	estrogen receptor 1	Homo sapiens	104-106
27283141-7	2016	alpha-Carotene, beta-carotene, lutein/zeaxanthin, and lycopene showed a protective effect on ER-/PR+ or ER-/PR- breast cancer.	Lycopene	54-62	progesterone receptor	Homo sapiens	108-110
26816095-7	2016	Lycopene also improved mitochondrial complex activities and restored ATP levels in Abeta-treated neuron.	Lycopene	0-8	amyloid beta precursor protein	Rattus norvegicus	83-88
26816095-3	2016	We observed previously that lycopene, a member of the carotenoid family of phytochemicals, could counteract neuronal apoptosis and cell damage induced by Abeta and other neurotoxic substances, and that this neuroprotective action somehow involved the mitochondria.	Lycopene	28-36	amyloid beta precursor protein	Rattus norvegicus	154-159
26816095-9	2016	Those results indicate that lycopene protects mitochondria against Abeta-induced damages, at least in part by inhibiting mitochondrial oxidative stress and improving mitochondrial function.	Lycopene	28-36	amyloid beta precursor protein	Rattus norvegicus	67-72
26816095-4	2016	The present study aims to investigate the effects of lycopene on mitochondria in cultured rat cortical neurons exposed to Abeta.	Lycopene	53-61	amyloid beta precursor protein	Rattus norvegicus	122-127
26816095-5	2016	It was found that lycopene attenuated Abeta-induced oxidative stress, as evidenced by the decreased intracellular reactive oxygen species generation and mitochondria-derived superoxide production.	Lycopene	18-26	amyloid beta precursor protein	Rattus norvegicus	38-43
26816095-10	2016	These beneficial effects of lycopene may account for its protection against Abeta-induced neurotoxicity.	Lycopene	28-36	amyloid beta precursor protein	Rattus norvegicus	76-81
26936958-9	2016	Moreover, increasing dietary lycopene level suppressed muscle Keap1 expression and enhanced muscle Nrf2 expression, which had increased by 150% and decreased by 40%, respectively in response to HS.	Lycopene	29-37	kelch like ECH associated protein 1	Gallus gallus	62-67
27035331-3	2016	In the present study, pretreatment with lycopene was observed to protect SH-SY5Y neuroblastoma cells against H2O2-induced death via inhibition of apoptosis resulting from activation of caspase-3 and translocation of apoptosis inducing factor (AIF) to the nucleus.	Lycopene	40-48	caspase 3	Homo sapiens	185-194
27035331-3	2016	In the present study, pretreatment with lycopene was observed to protect SH-SY5Y neuroblastoma cells against H2O2-induced death via inhibition of apoptosis resulting from activation of caspase-3 and translocation of apoptosis inducing factor (AIF) to the nucleus.	Lycopene	40-48	apoptosis inducing factor mitochondria associated 1	Homo sapiens	216-241
27035331-3	2016	In the present study, pretreatment with lycopene was observed to protect SH-SY5Y neuroblastoma cells against H2O2-induced death via inhibition of apoptosis resulting from activation of caspase-3 and translocation of apoptosis inducing factor (AIF) to the nucleus.	Lycopene	40-48	apoptosis inducing factor mitochondria associated 1	Homo sapiens	243-246
27035331-5	2016	Additionally, lycopene counteracted H2O2-induced mitochondrial dysfunction, which was evidenced by suppression of mitochondrial permeability transition pore opening, attenuation of the decline of the mitochondrial membrane potential, and inhibition of the increase of Bax and decrease of Bcl-2 levels within the mitochondria.	Lycopene	14-22	BCL2 associated X, apoptosis regulator	Homo sapiens	268-271
27035331-5	2016	Additionally, lycopene counteracted H2O2-induced mitochondrial dysfunction, which was evidenced by suppression of mitochondrial permeability transition pore opening, attenuation of the decline of the mitochondrial membrane potential, and inhibition of the increase of Bax and decrease of Bcl-2 levels within the mitochondria.	Lycopene	14-22	BCL2 apoptosis regulator	Homo sapiens	288-293
25818123-12	2016	This same dose of lycopene also significantly decreased high malondialdehyde level and myeloperoxidase activity, and increased the activity of antioxidant enzymes (with the exception of catalase) in tissue.	Lycopene	18-26	myeloperoxidase	Rattus norvegicus	87-102
26900785-0	2016	Lycopene modulates cholinergic dysfunction, Bcl-2/Bax balance, and antioxidant enzymes gene transcripts in monosodium glutamate (E621) induced neurotoxicity in a rat model.	Lycopene	0-8	BCL2, apoptosis regulator	Rattus norvegicus	44-49
26900785-0	2016	Lycopene modulates cholinergic dysfunction, Bcl-2/Bax balance, and antioxidant enzymes gene transcripts in monosodium glutamate (E621) induced neurotoxicity in a rat model.	Lycopene	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	50-53
26900785-5	2016	Glutathione S-transferase (GST), superoxide dismutase (SOD), and catalase (CAT) activities and gene expression were increased and glutathione content was reduced in the MSG-challenged rats, and these effects were ameliorated by lycopene.	Lycopene	228-236	hematopoietic prostaglandin D synthase	Rattus norvegicus	0-25
26900785-6	2016	Furthermore, MSG induced apoptosis in brain tissues reflected in upregulation of pro-apoptotic Bax while lycopene upregulated the anti-apoptotic Bcl-2.	Lycopene	105-113	BCL2, apoptosis regulator	Rattus norvegicus	145-150
26900785-7	2016	Our results indicate that lycopene appears to be highly effective in relieving the toxic effects of MSG by inhibiting lipid peroxidation and inducing modifications in the activity of cholinesterase and antioxidant pathways.	Lycopene	26-34	butyrylcholinesterase	Rattus norvegicus	183-197
25818123-12	2016	This same dose of lycopene also significantly decreased high malondialdehyde level and myeloperoxidase activity, and increased the activity of antioxidant enzymes (with the exception of catalase) in tissue.	Lycopene	18-26	catalase	Rattus norvegicus	186-194
26893492-2	2016	One of the enzymes in carotenoid biosynthesis is lycopene beta-cyclase (LCYB) that catalyzes the conversion of lycopene into beta-carotene.	Lycopene	49-57	lycopene beta cyclase, chloroplastic	Nicotiana tabacum	72-76
27313849-5	2016	IGF-1 concentrations were significantly positively associated with serum concentrations of lycopene, beta-carotene, alpha-carotene, beta-cryptoxanthin and lutein/zeaxanthin in men and women.	Lycopene	91-99	insulin like growth factor 1	Homo sapiens	0-5
27313849-7	2016	The IGF-1:IGFBP-3 molar ratio was significantly positively associated with serum concentrations of lycopene, beta-carotene and alpha-carotene in men and with beta-carotene in women.	Lycopene	99-107	insulin like growth factor 1	Homo sapiens	4-9
27313849-7	2016	The IGF-1:IGFBP-3 molar ratio was significantly positively associated with serum concentrations of lycopene, beta-carotene and alpha-carotene in men and with beta-carotene in women.	Lycopene	99-107	insulin like growth factor binding protein 3	Homo sapiens	10-17
26549245-7	2016	Lycopene treatment suppressed the OVX-induced increase in bone turnover, as indicated by changes in biomarkers of bone metabolism: serum osteocalcin (s-OC), serum N-terminal propeptide of type 1 collagen (s-PINP), serum crosslinked carboxyterminal telopeptides (s-CTX-1), and urinary deoxypyridinoline (u-DPD).	Lycopene	0-8	bone gamma-carboxyglutamate protein	Rattus norvegicus	137-148
26861389-0	2016	A Common Variant in the SETD7 Gene Predicts Serum Lycopene Concentrations.	Lycopene	50-58	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	24-29
26861389-6	2016	Variant rs7680948 on chromosome 4, located in the intron region of the SETD7 gene, was significantly associated with serum lycopene concentrations (p = 3.41 x 10(-9)).	Lycopene	123-131	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	71-76
26861389-7	2016	Our findings also provided nominal support for the association previously noted between SCARB1 and serum lycopene concentrations, although with a different SNP (rs11057841) in the region.	Lycopene	105-113	scavenger receptor class B member 1	Homo sapiens	88-94
26861389-8	2016	This study identified a novel locus associated with serum lycopene concentrations and our results raise a number of intriguing possibilities regarding the nature of the relationship between SETD7 and lycopene, both of which have been independently associated with prostate cancer.	Lycopene	58-66	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	190-195
26861389-8	2016	This study identified a novel locus associated with serum lycopene concentrations and our results raise a number of intriguing possibilities regarding the nature of the relationship between SETD7 and lycopene, both of which have been independently associated with prostate cancer.	Lycopene	200-208	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	190-195
26950150-7	2016	Intravenous administration of lycopene to achieve 1 muM concentration in circulating blood significantly suppressed MI, ROS production, and JNK phosphorylation in the cardiac tissue of mice during in vivo regional I/R.	Lycopene	30-38	mitogen-activated protein kinase 8	Mus musculus	140-143
26817504-0	2016	Dietary lycopene intake and risk of prostate cancer defined by ERG protein expression.	Lycopene	8-16	ETS transcription factor ERG	Homo sapiens	63-66
26847233-0	2016	MicroRNA-let-7f-1 is induced by lycopene and inhibits cell proliferation and triggers apoptosis in prostate cancer.	Lycopene	32-40	microRNA let-7f-1	Homo sapiens	0-17
26847233-3	2016	PC3 cells were treated with different concentrations of lycopene for 24 and 48 h, the level of protein kinase B (AKT2) was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blotting.	Lycopene	56-64	AKT serine/threonine kinase 2	Homo sapiens	113-117
26847233-6	2016	It was observed that lycopene downregulated the expression of AKT2 and upregulated the expression of miR-let-7f-1 in PC3 cells.	Lycopene	21-29	AKT serine/threonine kinase 2	Homo sapiens	62-66
26847233-6	2016	It was observed that lycopene downregulated the expression of AKT2 and upregulated the expression of miR-let-7f-1 in PC3 cells.	Lycopene	21-29	microRNA let-7f-1	Homo sapiens	105-113
26847233-9	2016	The results of the current study indicate that miR-let-7f-1 is involved in the anticancer effects of lycopene and serves an important role in the inhibition of prostate cancer progression through the downregulation of AKT2.	Lycopene	101-109	microRNA let-7f-1	Homo sapiens	51-59
26847233-9	2016	The results of the current study indicate that miR-let-7f-1 is involved in the anticancer effects of lycopene and serves an important role in the inhibition of prostate cancer progression through the downregulation of AKT2.	Lycopene	101-109	AKT serine/threonine kinase 2	Homo sapiens	218-222
26585352-8	2016	SNPs rs25489 in XRCC1, rs699473 in SOD3 and rs1052133 in OGG1 modified these associations for alpha-carotene, beta-carotene and lycopene, respectively (P &lt;= 0.05).	Lycopene	128-136	X-ray repair cross complementing 1	Homo sapiens	16-21
26585352-8	2016	SNPs rs25489 in XRCC1, rs699473 in SOD3 and rs1052133 in OGG1 modified these associations for alpha-carotene, beta-carotene and lycopene, respectively (P &lt;= 0.05).	Lycopene	128-136	superoxide dismutase 3	Homo sapiens	35-39
26585352-8	2016	SNPs rs25489 in XRCC1, rs699473 in SOD3 and rs1052133 in OGG1 modified these associations for alpha-carotene, beta-carotene and lycopene, respectively (P &lt;= 0.05).	Lycopene	128-136	8-oxoguanine DNA glycosylase	Homo sapiens	57-61
26585352-10	2016	Among men with Gleason score &lt;= 3 + 4, higher lycopene levels were associated with lower FGA (P = 0.04).	Lycopene	49-57	fibrinogen alpha chain	Homo sapiens	92-95
26848958-0	2016	Correction: Lycopene and Beta-Carotene Induce Growth Inhibition and Proapoptotic Effects on ACTH-Secreting Pituitary Adenoma Cells.	Lycopene	12-20	proopiomelanocortin	Homo sapiens	92-96
26549245-10	2016	Lycopene treatment down-regulated osteoclast differentiation concurrent with up-regulating osteoblast together with glutathione peroxidase (GPx) catalase (CAT) and superoxide dismutase (SOD) activities.	Lycopene	0-8	catalase	Rattus norvegicus	145-153
26549245-10	2016	Lycopene treatment down-regulated osteoclast differentiation concurrent with up-regulating osteoblast together with glutathione peroxidase (GPx) catalase (CAT) and superoxide dismutase (SOD) activities.	Lycopene	0-8	catalase	Rattus norvegicus	155-158
28721756-10	2016	Treatments with lycopene in the colitis decreased MDA, total sialic acid and DNA fragmentation levels, while SOD activity (p &lt; 0.05), TAS (in colon p &lt; 0.05; in serum p &lt; 0.01), CPN (p &lt; 0.05) and Fe levels (p &lt; 0.05) were significantly increased.	Lycopene	16-24	ceruloplasmin	Rattus norvegicus	187-190
26664697-7	2016	In irradiated cells, lycopene preexposure resulted in overexpression of BAX gene compared to nonexposed irradiated cells.	Lycopene	21-29	BCL2 associated X, apoptosis regulator	Homo sapiens	72-75
26572165-0	2016	Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway.	Lycopene	27-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	124-128
26572165-0	2016	Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway.	Lycopene	27-35	heme oxygenase 1	Rattus norvegicus	129-133
26572165-10	2016	Lycopene increased the expression levels of Nrf2 and HO-1, indicating that the Nrf2/HO-1 signaling pathway may be involved in the neuroprotective effect of lycopene.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	44-48
26572165-10	2016	Lycopene increased the expression levels of Nrf2 and HO-1, indicating that the Nrf2/HO-1 signaling pathway may be involved in the neuroprotective effect of lycopene.	Lycopene	0-8	heme oxygenase 1	Mus musculus	53-57
26572165-10	2016	Lycopene increased the expression levels of Nrf2 and HO-1, indicating that the Nrf2/HO-1 signaling pathway may be involved in the neuroprotective effect of lycopene.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
26572165-10	2016	Lycopene increased the expression levels of Nrf2 and HO-1, indicating that the Nrf2/HO-1 signaling pathway may be involved in the neuroprotective effect of lycopene.	Lycopene	0-8	heme oxygenase 1	Mus musculus	84-88
26572165-10	2016	Lycopene increased the expression levels of Nrf2 and HO-1, indicating that the Nrf2/HO-1 signaling pathway may be involved in the neuroprotective effect of lycopene.	Lycopene	156-164	nuclear factor, erythroid derived 2, like 2	Mus musculus	44-48
26572165-10	2016	Lycopene increased the expression levels of Nrf2 and HO-1, indicating that the Nrf2/HO-1 signaling pathway may be involved in the neuroprotective effect of lycopene.	Lycopene	156-164	heme oxygenase 1	Mus musculus	53-57
26572165-10	2016	Lycopene increased the expression levels of Nrf2 and HO-1, indicating that the Nrf2/HO-1 signaling pathway may be involved in the neuroprotective effect of lycopene.	Lycopene	156-164	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83
26572165-10	2016	Lycopene increased the expression levels of Nrf2 and HO-1, indicating that the Nrf2/HO-1 signaling pathway may be involved in the neuroprotective effect of lycopene.	Lycopene	156-164	heme oxygenase 1	Mus musculus	84-88
26572165-11	2016	The present study revealed that lycopene protects the brain from global ischemic injury, which is associated with its antiapoptotic effect and the activation of the Nrf2/HO-1 signaling pathway.	Lycopene	32-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	165-169
26572165-11	2016	The present study revealed that lycopene protects the brain from global ischemic injury, which is associated with its antiapoptotic effect and the activation of the Nrf2/HO-1 signaling pathway.	Lycopene	32-40	heme oxygenase 1	Mus musculus	170-174
26482064-10	2016	Stratified analysis by menopausal status and oestrogen receptor (ER)/progesterone receptor (PR) showed that serum alpha-carotene, beta-carotene, lycopene and lutein/zeaxanthin were inversely associated with breast cancer risk among premenopausal women and among all subtypes of ER or PR status.	Lycopene	145-153	progesterone receptor	Homo sapiens	69-90
27833962-11	2016	Lycopene increased the expression of connexin-43 in the primordial, secondary and large antral follicles in the ovaries of diabetic animals.	Lycopene	0-8	gap junction protein, alpha 1	Rattus norvegicus	37-48
26535076-4	2015	Although H2O2 (200 muM) increased intracellular ROS levels in human MSCs, lycopene (10 muM) pretreatment suppressed H2O2-induced ROS generation and increased survival.	Lycopene	74-82	latexin	Homo sapiens	87-90
26453763-5	2015	Lycopene treatment reduced Abeta1-42 secretion in SH-SY5Y cells overexpressing the Swedish mutant form of human beta-amyloid precursor protein (APPsw).	Lycopene	0-8	amyloid beta precursor protein	Homo sapiens	112-142
26453763-6	2015	Next, we found lycopene can down-regulate expression level of beta-amyloid precursor protein(APP) in APPsw cells.	Lycopene	15-23	amyloid beta precursor protein	Homo sapiens	62-92
26165176-9	2015	Percent increase in beta-cryptoxanthin, cis-lutein/zeaxanthin and all-trans-lycopene were associated with lower PSA levels at 6 months only.	Lycopene	66-84	kallikrein related peptidase 3	Homo sapiens	112-115
26535076-5	2015	H2O2-induced ROS increased the levels of phosphorylated p38 mitogen activated protein kinase (MAPK), Jun-N-terminal kinase (JNK), ataxia telangiectasia mutated (ATM), and p53, which were inhibited by lycopene pretreatment.	Lycopene	200-208	ATM serine/threonine kinase	Homo sapiens	161-164
26535076-6	2015	Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment.	Lycopene	13-21	poly(ADP-ribose) polymerase 1	Homo sapiens	71-101
26535076-6	2015	Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment.	Lycopene	13-21	poly(ADP-ribose) polymerase 1	Homo sapiens	103-109
26535076-6	2015	Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment.	Lycopene	13-21	caspase 3	Homo sapiens	115-124
26535076-6	2015	Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment.	Lycopene	13-21	BCL2 apoptosis regulator	Homo sapiens	157-174
26535076-6	2015	Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment.	Lycopene	13-21	BCL2 apoptosis regulator	Homo sapiens	176-181
26535076-6	2015	Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment.	Lycopene	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	187-213
26535076-6	2015	Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment.	Lycopene	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	215-218
26535076-7	2015	Moreover, lycopene significantly increased manganese superoxide dismutase (MnSOD) expression and decreased cellular ROS levels via the PI3K-Akt pathway.	Lycopene	10-18	superoxide dismutase 2	Homo sapiens	43-73
26535076-7	2015	Moreover, lycopene significantly increased manganese superoxide dismutase (MnSOD) expression and decreased cellular ROS levels via the PI3K-Akt pathway.	Lycopene	10-18	superoxide dismutase 2	Homo sapiens	75-80
26264562-0	2015	Lycopene reduces cholesterol absorption through the downregulation of Niemann-Pick C1-like 1 in Caco-2 cells.	Lycopene	0-8	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	70-92
26264562-6	2015	We found that lycopene dose dependently inhibited cholesterol absorption and the expression of NPC1L1 protein and NPC1L1 mRNA.	Lycopene	14-22	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	95-101
26264562-6	2015	We found that lycopene dose dependently inhibited cholesterol absorption and the expression of NPC1L1 protein and NPC1L1 mRNA.	Lycopene	14-22	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	114-120
26264562-7	2015	The inhibitory effects of lycopene on cholesterol absorption and NPC1L1 expression could be prevented by blockade of the LXRalpha pathway.	Lycopene	26-34	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	65-71
26264562-7	2015	The inhibitory effects of lycopene on cholesterol absorption and NPC1L1 expression could be prevented by blockade of the LXRalpha pathway.	Lycopene	26-34	nuclear receptor subfamily 1 group H member 3	Homo sapiens	121-129
26264562-8	2015	CONCLUSION: This study provides the first evidence that lycopene inhibits cholesterol absorption in the intestinal cells and this inhibitory effect of lycopene is mediated, at least in part, by LXRalpha-NPC1L1 signaling pathway.	Lycopene	151-159	nuclear receptor subfamily 1 group H member 3	Homo sapiens	194-202
26264562-8	2015	CONCLUSION: This study provides the first evidence that lycopene inhibits cholesterol absorption in the intestinal cells and this inhibitory effect of lycopene is mediated, at least in part, by LXRalpha-NPC1L1 signaling pathway.	Lycopene	151-159	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	203-209
26179622-11	2015	When ZWF1 and POS5 were overexpressed in a carotenoid-producing S. cerevisiae strain individually, the total yield of lycopene and beta-carotene increased by 59 9% and 81 4%, respectively, and the final product beta-carotene yield increased by 18 8% and 65 6% respectively.	Lycopene	118-126	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	5-9
26179622-11	2015	When ZWF1 and POS5 were overexpressed in a carotenoid-producing S. cerevisiae strain individually, the total yield of lycopene and beta-carotene increased by 59 9% and 81 4%, respectively, and the final product beta-carotene yield increased by 18 8% and 65 6% respectively.	Lycopene	118-126	NADH kinase	Saccharomyces cerevisiae S288C	14-18
26179622-5	2015	When ZWF1 was overexpressed (Sc-EYBIZH+I), glucose-6-phosphate dehydrogenase activity increased by 103-fold, the transcription level of crtE and crtI increased significantly, the lycopene and beta-carotene yield increased to 2 29 +- 0 06 and 0 38 +- 0 02 mg l(-1) respectively.	Lycopene	179-187	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	5-9
26179622-6	2015	When POS5 was overexpressed (Sc-EYBIPH+I), NAD kinase activity increased by 5 5-fold, the transcription level of crtE, crtYB and crtI increased obviously, the lycopene and beta-carotene yield increased to 2 50 +- 0 11 and 0 53 +- 0 03 mg l(-1) respectively.	Lycopene	159-167	NADH kinase	Saccharomyces cerevisiae S288C	5-9
25656550-8	2015	I/R-injury decreased the protein level of a key activator of mt transcription, mitochondrial transcription factor A (Tfam), which was blocked by lycopene.	Lycopene	145-153	transcription factor A, mitochondrial	Rattus norvegicus	117-121
26453295-0	2015	Lycopene powers the inhibition of glycation-induced diabetic nephropathy: a novel approach to halt the AGE-RAGE axis menace.	Lycopene	0-8	advanced glycosylation end product-specific receptor	Rattus norvegicus	107-111
26453295-5	2015	We observed that treatment with lycopene decelerated the ribose induced AGE formation in HK-2 cells and in rat kidneys thereby downregulating the expression RAGE.	Lycopene	32-40	advanced glycosylation end product-specific receptor	Rattus norvegicus	157-161
26453295-9	2015	Thus lycopene provides protection against development of diabetic nephropathy and ameliorates renal function by halting AGE-RAGE axis.	Lycopene	5-13	advanced glycosylation end product-specific receptor	Rattus norvegicus	124-128
25656550-9	2015	The protective effect of lycopene on mtDNA was associated with a reduction in mitochondrial ROS production and stabilization of Tfam.	Lycopene	25-33	transcription factor A, mitochondrial	Rattus norvegicus	128-132
26291709-7	2015	Our results showed that lycopene was able to prevent TG-induced ER stress as reflected by attenuating the protein expression of GRP78 and CHOP/GADD153 compared to TG group, significantly improve TG-caused a loss of cell viability and decrease apoptosis in TG-treated cardiomyocytes.	Lycopene	24-32	heat shock protein 5	Mus musculus	128-133
26291709-7	2015	Our results showed that lycopene was able to prevent TG-induced ER stress as reflected by attenuating the protein expression of GRP78 and CHOP/GADD153 compared to TG group, significantly improve TG-caused a loss of cell viability and decrease apoptosis in TG-treated cardiomyocytes.	Lycopene	24-32	DNA-damage inducible transcript 3	Mus musculus	138-142
26291709-7	2015	Our results showed that lycopene was able to prevent TG-induced ER stress as reflected by attenuating the protein expression of GRP78 and CHOP/GADD153 compared to TG group, significantly improve TG-caused a loss of cell viability and decrease apoptosis in TG-treated cardiomyocytes.	Lycopene	24-32	DNA-damage inducible transcript 3	Mus musculus	143-150
25932745-0	2015	Lycopene inhibits cyclic strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme oxygenase-1 in human umbilical vein endothelial cells.	Lycopene	0-8	endothelin 1	Homo sapiens	40-52
26104400-8	2015	Dietary lycopene intake linearly increased the plasma antioxidant vitamin E level (p&lt;0.001), total antioxidant capacity (T-AOC, p&lt;0.05), and activities of catalase (CAT, p&lt;0.01), glutathione peroxidase (GSH-Px, p&lt;0.05) and superoxide dismutase (SOD, p&lt;0.05).	Lycopene	8-16	catalase	Ovis aries	161-169
26104400-8	2015	Dietary lycopene intake linearly increased the plasma antioxidant vitamin E level (p&lt;0.001), total antioxidant capacity (T-AOC, p&lt;0.05), and activities of catalase (CAT, p&lt;0.01), glutathione peroxidase (GSH-Px, p&lt;0.05) and superoxide dismutase (SOD, p&lt;0.05).	Lycopene	8-16	catalase	Ovis aries	171-174
26104400-10	2015	In liver, dietary lycopene inclusion showed similar antioxidant effects with respect to activities of CAT (p&lt;0.05, linearly) and SOD (p&lt;0.001, linearly).	Lycopene	18-26	catalase	Ovis aries	102-105
25932745-0	2015	Lycopene inhibits cyclic strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme oxygenase-1 in human umbilical vein endothelial cells.	Lycopene	0-8	heme oxygenase 1	Homo sapiens	143-159
25932745-8	2015	Conversely, lycopene treatment enhanced heme oxygenase-1 (HO-1) gene expression through the activation of phosphoinositide 3-kinase (PI3K)/Akt pathway, followed by induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation; in addition, HO-1 silencing partially inhibited the repressive effects of lycopene on strain-induced ET-1 expression.	Lycopene	12-20	NFE2 like bZIP transcription factor 2	Homo sapiens	226-230
25932745-4	2015	This study investigated the effects of lycopene on cyclic strain-induced ET-1 gene expression in human umbilical vein endothelial cells (HUVECs) and identified the signal transduction pathways that are involved in this process.	Lycopene	39-47	endothelin 1	Homo sapiens	73-77
25932745-8	2015	Conversely, lycopene treatment enhanced heme oxygenase-1 (HO-1) gene expression through the activation of phosphoinositide 3-kinase (PI3K)/Akt pathway, followed by induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation; in addition, HO-1 silencing partially inhibited the repressive effects of lycopene on strain-induced ET-1 expression.	Lycopene	12-20	heme oxygenase 1	Homo sapiens	268-272
25932745-6	2015	Lycopene inhibited strain-induced ET-1 expression through the suppression of reactive oxygen species (ROS) generation through attenuation of p22(phox) mRNA expression and NAD(P)H oxidase activity.	Lycopene	0-8	endothelin 1	Homo sapiens	34-38
25932745-8	2015	Conversely, lycopene treatment enhanced heme oxygenase-1 (HO-1) gene expression through the activation of phosphoinositide 3-kinase (PI3K)/Akt pathway, followed by induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation; in addition, HO-1 silencing partially inhibited the repressive effects of lycopene on strain-induced ET-1 expression.	Lycopene	12-20	endothelin 1	Homo sapiens	356-360
25932745-6	2015	Lycopene inhibited strain-induced ET-1 expression through the suppression of reactive oxygen species (ROS) generation through attenuation of p22(phox) mRNA expression and NAD(P)H oxidase activity.	Lycopene	0-8	calcineurin like EF-hand protein 1	Homo sapiens	141-144
25932745-8	2015	Conversely, lycopene treatment enhanced heme oxygenase-1 (HO-1) gene expression through the activation of phosphoinositide 3-kinase (PI3K)/Akt pathway, followed by induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation; in addition, HO-1 silencing partially inhibited the repressive effects of lycopene on strain-induced ET-1 expression.	Lycopene	329-337	heme oxygenase 1	Homo sapiens	58-62
25932745-8	2015	Conversely, lycopene treatment enhanced heme oxygenase-1 (HO-1) gene expression through the activation of phosphoinositide 3-kinase (PI3K)/Akt pathway, followed by induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation; in addition, HO-1 silencing partially inhibited the repressive effects of lycopene on strain-induced ET-1 expression.	Lycopene	329-337	NFE2 like bZIP transcription factor 2	Homo sapiens	181-224
25932745-9	2015	In summary, our study showed, for the first time, that lycopene inhibits cyclic strain-induced ET-1 gene expression through the suppression of ROS generation and induction of HO-1 in HUVECs.	Lycopene	55-63	endothelin 1	Homo sapiens	95-99
25932745-9	2015	In summary, our study showed, for the first time, that lycopene inhibits cyclic strain-induced ET-1 gene expression through the suppression of ROS generation and induction of HO-1 in HUVECs.	Lycopene	55-63	heme oxygenase 1	Homo sapiens	175-179
25932745-7	2015	Furthermore, lycopene inhibited strain-induced ET-1 secretion by reducing ROS-mediated extrace-llular signal-regulated kinase (ERK) phosphorylation.	Lycopene	13-21	endothelin 1	Homo sapiens	47-51
25932745-8	2015	Conversely, lycopene treatment enhanced heme oxygenase-1 (HO-1) gene expression through the activation of phosphoinositide 3-kinase (PI3K)/Akt pathway, followed by induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation; in addition, HO-1 silencing partially inhibited the repressive effects of lycopene on strain-induced ET-1 expression.	Lycopene	12-20	heme oxygenase 1	Homo sapiens	40-56
25932745-8	2015	Conversely, lycopene treatment enhanced heme oxygenase-1 (HO-1) gene expression through the activation of phosphoinositide 3-kinase (PI3K)/Akt pathway, followed by induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation; in addition, HO-1 silencing partially inhibited the repressive effects of lycopene on strain-induced ET-1 expression.	Lycopene	12-20	heme oxygenase 1	Homo sapiens	58-62
25932745-8	2015	Conversely, lycopene treatment enhanced heme oxygenase-1 (HO-1) gene expression through the activation of phosphoinositide 3-kinase (PI3K)/Akt pathway, followed by induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation; in addition, HO-1 silencing partially inhibited the repressive effects of lycopene on strain-induced ET-1 expression.	Lycopene	12-20	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	106-131
25932745-8	2015	Conversely, lycopene treatment enhanced heme oxygenase-1 (HO-1) gene expression through the activation of phosphoinositide 3-kinase (PI3K)/Akt pathway, followed by induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation; in addition, HO-1 silencing partially inhibited the repressive effects of lycopene on strain-induced ET-1 expression.	Lycopene	12-20	AKT serine/threonine kinase 1	Homo sapiens	139-142
25932745-8	2015	Conversely, lycopene treatment enhanced heme oxygenase-1 (HO-1) gene expression through the activation of phosphoinositide 3-kinase (PI3K)/Akt pathway, followed by induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation; in addition, HO-1 silencing partially inhibited the repressive effects of lycopene on strain-induced ET-1 expression.	Lycopene	12-20	NFE2 like bZIP transcription factor 2	Homo sapiens	181-224
25672622-3	2015	Health-promoting nutrients and other factors act, at least in part by raising Nrf2 including: many phenolic antioxidants; gamma- and delta-tocopherols and tocotrienols; long chain omega-3 fatty acids DHA and EPA; many carotenoids of which lycopene may be the most active; isothiocyanates from cruciferous vegetables; sulfur compounds from allium vegetables; terpenoids.	Lycopene	239-247	NFE2 like bZIP transcription factor 2	Homo sapiens	78-82
25888837-5	2015	Lycopene further embarked diminishing effect on oxidative stress through synchronising lipid and protein peroxidation along with regulating the enzymatic activity of SOD and catalase.	Lycopene	0-8	catalase	Rattus norvegicus	174-182
25888837-6	2015	Lycopene also modified the levels of immunoregulatory cytokines (IL- 1beta and IL-6) favourably.	Lycopene	0-8	interleukin 1 beta	Rattus norvegicus	65-74
25888837-6	2015	Lycopene also modified the levels of immunoregulatory cytokines (IL- 1beta and IL-6) favourably.	Lycopene	0-8	interleukin 6	Rattus norvegicus	79-83
25689917-9	2015	The immunohistochemical experiment exhibited that lycopene intake contributed to attenuation of nuclear factor-kappa B (NF-kappaB) and tumor necrosis factor alpha (TNF-alpha) expressions in kidney tissue.	Lycopene	50-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	96-118
25689917-9	2015	The immunohistochemical experiment exhibited that lycopene intake contributed to attenuation of nuclear factor-kappa B (NF-kappaB) and tumor necrosis factor alpha (TNF-alpha) expressions in kidney tissue.	Lycopene	50-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-129
25689917-9	2015	The immunohistochemical experiment exhibited that lycopene intake contributed to attenuation of nuclear factor-kappa B (NF-kappaB) and tumor necrosis factor alpha (TNF-alpha) expressions in kidney tissue.	Lycopene	50-58	tumor necrosis factor	Mus musculus	135-162
25689917-9	2015	The immunohistochemical experiment exhibited that lycopene intake contributed to attenuation of nuclear factor-kappa B (NF-kappaB) and tumor necrosis factor alpha (TNF-alpha) expressions in kidney tissue.	Lycopene	50-58	tumor necrosis factor	Mus musculus	164-173
25689917-10	2015	Moreover, intrarenal HO-1 level was up-regulated in the presence of lycopene.	Lycopene	68-76	heme oxygenase 1	Mus musculus	21-25
26082367-1	2015	OBJECTIVE: To investigate the effect of Lycopene (Lyc) on Ang II induced oxidative stress in H9c2 cell line derived from rat cardiac tissue,and to explore related mechanisms.	Lycopene	40-48	angiogenin	Rattus norvegicus	58-61
26082367-1	2015	OBJECTIVE: To investigate the effect of Lycopene (Lyc) on Ang II induced oxidative stress in H9c2 cell line derived from rat cardiac tissue,and to explore related mechanisms.	Lycopene	40-43	angiogenin	Rattus norvegicus	58-61
25682699-5	2015	Lycopene was also effective in protecting against the decrease in glutathione-S-transferase, glutathione peroxidase, glutathione reductase and delta-aminolevulinic acid dehydratase activities caused by ZEA in the testes.	Lycopene	0-8	hematopoietic prostaglandin D synthase	Mus musculus	66-91
25682699-5	2015	Lycopene was also effective in protecting against the decrease in glutathione-S-transferase, glutathione peroxidase, glutathione reductase and delta-aminolevulinic acid dehydratase activities caused by ZEA in the testes.	Lycopene	0-8	glutathione reductase	Mus musculus	117-138
25632967-0	2015	Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats.	Lycopene	0-8	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	48-59
25632967-0	2015	Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats.	Lycopene	0-8	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	93-104
25632967-0	2015	Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats.	Lycopene	0-8	sirtuin 1	Rattus norvegicus	106-111
25632967-0	2015	Lycopene-rich tomato oleoresin modulates plasma adiponectin concentration and mRNA levels of adiponectin, SIRT1, and FoxO1 in adipose tissue of obese rats.	Lycopene	0-8	forkhead box O1	Rattus norvegicus	117-122
25632967-1	2015	AIM: To investigate whether lycopene can modulate adiponectin levels and SIRT1 and FoxO1 gene expression in the adipose tissue of diet-induced obese rats.	Lycopene	28-36	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	50-61
25632967-1	2015	AIM: To investigate whether lycopene can modulate adiponectin levels and SIRT1 and FoxO1 gene expression in the adipose tissue of diet-induced obese rats.	Lycopene	28-36	sirtuin 1	Rattus norvegicus	73-78
25632967-7	2015	In addition, the lycopene supplementation upregulated mRNA expressions of SIRT1, FoxO1, and FAT/CD36 but downregulated PPARgamma in adipose tissue of obese rats.	Lycopene	17-25	sirtuin 1	Rattus norvegicus	74-79
25632967-7	2015	In addition, the lycopene supplementation upregulated mRNA expressions of SIRT1, FoxO1, and FAT/CD36 but downregulated PPARgamma in adipose tissue of obese rats.	Lycopene	17-25	forkhead box O1	Rattus norvegicus	81-86
25602702-0	2015	Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model.	Lycopene	0-8	TSC complex subunit 2	Rattus norvegicus	55-59
25602702-3	2015	This study examines the role of a lycopene-rich diet in the development of RCC in the TSC2 mutant Eker rat model.	Lycopene	34-42	TSC complex subunit 2	Rattus norvegicus	86-90
25602702-14	2015	In conclusion, dietary supplementation with lycopene attenuates the development of renal cell cancers in the predisposed TSC2 mutant Eker rat model.	Lycopene	44-52	TSC complex subunit 2	Rattus norvegicus	121-125
25687103-0	2015	Engineering of global regulator cAMP receptor protein (CRP) in Escherichia coli for improved lycopene production.	Lycopene	93-101	catabolite gene activator protein	Escherichia coli	32-53
25687103-0	2015	Engineering of global regulator cAMP receptor protein (CRP) in Escherichia coli for improved lycopene production.	Lycopene	93-101	catabolite gene activator protein	Escherichia coli	55-58
25687103-2	2015	In this study, engineering of the cAMP receptor protein (CRP) was explored with the aim of subtly balancing entire pathway networks and potentially improving lycopene production without significant genetic intervention in other pathways.	Lycopene	158-166	catabolite gene activator protein	Escherichia coli	34-55
25687103-2	2015	In this study, engineering of the cAMP receptor protein (CRP) was explored with the aim of subtly balancing entire pathway networks and potentially improving lycopene production without significant genetic intervention in other pathways.	Lycopene	158-166	catabolite gene activator protein	Escherichia coli	57-60
25687103-5	2015	The best mutant gene (mcrp26) was integrated into the genome of E. coli BW25113-BIE to replace the wild-type crp gene (MT-1), which resulted in a higher lycopene production (18.49mg/g DCW) compared to the original strain (WT).	Lycopene	153-161	catabolite gene activator protein	Escherichia coli	23-26
25689917-11	2015	Our findings provide the evidence that lycopene protects kidney cells from STZ-induced lesions via inhibiting NF-kappaB signal pathway for anti-inflammation and attenuating oxidative stress for anti-dysmetabolism.	Lycopene	39-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-119
25682699-5	2015	Lycopene was also effective in protecting against the decrease in glutathione-S-transferase, glutathione peroxidase, glutathione reductase and delta-aminolevulinic acid dehydratase activities caused by ZEA in the testes.	Lycopene	0-8	aminolevulinate, delta-, dehydratase	Mus musculus	143-180
25385104-8	2015	Lycopene treatment, especially in the colistin plus lycopene (20 mg/kg) group, significantly downregulated the expression of NF-kappaB mRNA (P &lt; 0.01) but upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both P &lt; 0.01) in the kidney compared with the results seen with the colistin group.	Lycopene	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-134
25644336-8	2015	RESULTS: In the meta-analysis, the scavenger receptor class B, member 1 (SCARB1) gene, which encodes for a cholesterol membrane transporter, was significantly associated with lycopene concentrations (rs1672879; P &lt; 2.68 x 10(-9)).	Lycopene	175-183	scavenger receptor class B member 1	Homo sapiens	35-71
25644336-8	2015	RESULTS: In the meta-analysis, the scavenger receptor class B, member 1 (SCARB1) gene, which encodes for a cholesterol membrane transporter, was significantly associated with lycopene concentrations (rs1672879; P &lt; 2.68 x 10(-9)).	Lycopene	175-183	scavenger receptor class B member 1	Homo sapiens	73-79
25644336-10	2015	In addition, 2 regions were significantly associated with serum lycopene concentrations in African Americans: the slit homolog 3 gene (SLIT3), which serves as a molecular guidance cue in cellular migration, and the dehydrogenase/reductase (SDR family) member 2 (DHRS2) gene, which codes for an oxidoreductase that mitigates the breakdown of steroids.	Lycopene	64-72	slit guidance ligand 3	Homo sapiens	114-128
25644336-10	2015	In addition, 2 regions were significantly associated with serum lycopene concentrations in African Americans: the slit homolog 3 gene (SLIT3), which serves as a molecular guidance cue in cellular migration, and the dehydrogenase/reductase (SDR family) member 2 (DHRS2) gene, which codes for an oxidoreductase that mitigates the breakdown of steroids.	Lycopene	64-72	slit guidance ligand 3	Homo sapiens	135-140
25644336-10	2015	In addition, 2 regions were significantly associated with serum lycopene concentrations in African Americans: the slit homolog 3 gene (SLIT3), which serves as a molecular guidance cue in cellular migration, and the dehydrogenase/reductase (SDR family) member 2 (DHRS2) gene, which codes for an oxidoreductase that mitigates the breakdown of steroids.	Lycopene	64-72	dehydrogenase/reductase 2	Homo sapiens	215-260
25644336-10	2015	In addition, 2 regions were significantly associated with serum lycopene concentrations in African Americans: the slit homolog 3 gene (SLIT3), which serves as a molecular guidance cue in cellular migration, and the dehydrogenase/reductase (SDR family) member 2 (DHRS2) gene, which codes for an oxidoreductase that mitigates the breakdown of steroids.	Lycopene	64-72	dehydrogenase/reductase 2	Homo sapiens	262-267
25644336-10	2015	In addition, 2 regions were significantly associated with serum lycopene concentrations in African Americans: the slit homolog 3 gene (SLIT3), which serves as a molecular guidance cue in cellular migration, and the dehydrogenase/reductase (SDR family) member 2 (DHRS2) gene, which codes for an oxidoreductase that mitigates the breakdown of steroids.	Lycopene	64-72	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	294-308
25644347-5	2015	RESULTS: Lycopene or APO10LA supplementation reduced hepatic steatosis incidence (78% and 72%, respectively) and severity in BCO2-KO male mice.	Lycopene	9-17	beta-carotene oxygenase 2	Mus musculus	125-129
25644347-11	2015	CONCLUSIONS: Our data suggest that lycopene and APO10LA inhibit HSFD-induced steatosis in BCO2-KO male mice through differential mechanisms.	Lycopene	35-43	beta-carotene oxygenase 2	Mus musculus	90-94
25410533-0	2015	Lycopene protects pancreatic acinar cells against severe acute pancreatitis by abating the oxidative stress through JNK pathway.	Lycopene	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	116-119
25410533-2	2015	Utilizing a rat model, we found that lycopene administration protected against SAP, as indicated by the decreased levels of serum amylase and C-reactive protein.	Lycopene	37-45	C-reactive protein	Rattus norvegicus	142-160
25410533-4	2015	The serum levels of tumor necrosis factor-alpha, interleukin-6, macrophage inflammatory protein-1alpha, and monocyte chemotactic protein-1 were decreased by lycopene.	Lycopene	157-165	tumor necrosis factor	Rattus norvegicus	20-47
25410533-4	2015	The serum levels of tumor necrosis factor-alpha, interleukin-6, macrophage inflammatory protein-1alpha, and monocyte chemotactic protein-1 were decreased by lycopene.	Lycopene	157-165	interleukin 6	Rattus norvegicus	49-62
25410533-4	2015	The serum levels of tumor necrosis factor-alpha, interleukin-6, macrophage inflammatory protein-1alpha, and monocyte chemotactic protein-1 were decreased by lycopene.	Lycopene	157-165	C-C motif chemokine ligand 3	Rattus norvegicus	64-102
25410533-4	2015	The serum levels of tumor necrosis factor-alpha, interleukin-6, macrophage inflammatory protein-1alpha, and monocyte chemotactic protein-1 were decreased by lycopene.	Lycopene	157-165	C-C motif chemokine ligand 2	Rattus norvegicus	108-138
25410533-5	2015	The decreased reactive oxygen species (ROS) content in the pancreatic tissues of the lycopene-treated group were indirectly evaluated by measuring the levels of myeloperoxidase, lipid peroxidase, and superoxide dismutase.	Lycopene	85-93	myeloperoxidase	Rattus norvegicus	161-176
25410533-6	2015	Lycopene protected acinar cells against necrosis and apoptosis by relieving the mitochondrial and endoplasmic stress caused by ROS which was shown in electron microscopy and immunohistochemistry staining of active nuclear factor-kappaB p65.	Lycopene	0-8	synaptotagmin 1	Rattus norvegicus	236-239
25410533-9	2015	Lycopene exerts protective effects against SAP in rats that may be related to its anti-inflammatory property through inhibiting the expression of damage-associated molecular patterns, and anti-oxidative property which can thus maintain cellular homeostasis and prevent the phosphorylation of JNK pathway.	Lycopene	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	292-295
25385104-0	2015	Lycopene attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	82-86
25385104-0	2015	Lycopene attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway.	Lycopene	0-8	heme oxygenase 1	Mus musculus	87-91
25385104-8	2015	Lycopene treatment, especially in the colistin plus lycopene (20 mg/kg) group, significantly downregulated the expression of NF-kappaB mRNA (P &lt; 0.01) but upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both P &lt; 0.01) in the kidney compared with the results seen with the colistin group.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	188-231
25385104-8	2015	Lycopene treatment, especially in the colistin plus lycopene (20 mg/kg) group, significantly downregulated the expression of NF-kappaB mRNA (P &lt; 0.01) but upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both P &lt; 0.01) in the kidney compared with the results seen with the colistin group.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	233-237
25385104-8	2015	Lycopene treatment, especially in the colistin plus lycopene (20 mg/kg) group, significantly downregulated the expression of NF-kappaB mRNA (P &lt; 0.01) but upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both P &lt; 0.01) in the kidney compared with the results seen with the colistin group.	Lycopene	0-8	heme oxygenase 1	Mus musculus	243-247
25385104-8	2015	Lycopene treatment, especially in the colistin plus lycopene (20 mg/kg) group, significantly downregulated the expression of NF-kappaB mRNA (P &lt; 0.01) but upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both P &lt; 0.01) in the kidney compared with the results seen with the colistin group.	Lycopene	52-60	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-134
25385104-10	2015	This effect may be attributed to the antioxidative property of lycopene and its ability to activate the Nrf2/HO-1 pathway.	Lycopene	63-71	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-108
25385104-10	2015	This effect may be attributed to the antioxidative property of lycopene and its ability to activate the Nrf2/HO-1 pathway.	Lycopene	63-71	heme oxygenase 1	Mus musculus	109-113
25323011-2	2015	The nuclear factor kappaB (NF-kappaB) signaling pathway could promote inflammation and apoptosis and it has been demonstrated that lycopene inhibits cigarette smoke extract-mediated NF-kappaB activation.	Lycopene	131-139	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	19-25
25323011-2	2015	The nuclear factor kappaB (NF-kappaB) signaling pathway could promote inflammation and apoptosis and it has been demonstrated that lycopene inhibits cigarette smoke extract-mediated NF-kappaB activation.	Lycopene	131-139	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	27-36
25323011-2	2015	The nuclear factor kappaB (NF-kappaB) signaling pathway could promote inflammation and apoptosis and it has been demonstrated that lycopene inhibits cigarette smoke extract-mediated NF-kappaB activation.	Lycopene	131-139	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	182-191
25323011-3	2015	Therefore, it was hypothesized that the NF-kappaB signaling pathway may be a key target of lycopene in the reversal of ventricular remodeling post MI.	Lycopene	91-99	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	40-49
25323011-9	2015	Lycopene reduced the expression of TGF-beta1, collagen I, collagen III, TNF-alpha, IL-1beta, caspase-3, -8 and -9 and inhibited the activation of the NF-kappaB signaling pathway.	Lycopene	0-8	transforming growth factor, beta 1	Mus musculus	35-44
25323011-9	2015	Lycopene reduced the expression of TGF-beta1, collagen I, collagen III, TNF-alpha, IL-1beta, caspase-3, -8 and -9 and inhibited the activation of the NF-kappaB signaling pathway.	Lycopene	0-8	tumor necrosis factor	Mus musculus	72-81
25323011-9	2015	Lycopene reduced the expression of TGF-beta1, collagen I, collagen III, TNF-alpha, IL-1beta, caspase-3, -8 and -9 and inhibited the activation of the NF-kappaB signaling pathway.	Lycopene	0-8	interleukin 1 beta	Mus musculus	83-91
25323011-9	2015	Lycopene reduced the expression of TGF-beta1, collagen I, collagen III, TNF-alpha, IL-1beta, caspase-3, -8 and -9 and inhibited the activation of the NF-kappaB signaling pathway.	Lycopene	0-8	caspase 3	Mus musculus	93-113
25323011-9	2015	Lycopene reduced the expression of TGF-beta1, collagen I, collagen III, TNF-alpha, IL-1beta, caspase-3, -8 and -9 and inhibited the activation of the NF-kappaB signaling pathway.	Lycopene	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	150-159
25323011-11	2015	Lycopene may inhibit the NF-kappaB signaling pathway thereby reducing the inflammatory response and cardiomyocyte apoptosis post-MI, which could be a key mechanism of lycopene in attenuating ventricular remodeling.	Lycopene	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	25-34
25323011-11	2015	Lycopene may inhibit the NF-kappaB signaling pathway thereby reducing the inflammatory response and cardiomyocyte apoptosis post-MI, which could be a key mechanism of lycopene in attenuating ventricular remodeling.	Lycopene	167-175	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	25-34
25491370-8	2014	The results of yeast one-hybrid experiment demonstrated that SlNAC1 can interact with the regulatory regions of genes related lycopene and ethylene synthesis.	Lycopene	126-134	NAC domain protein	Solanum lycopersicum	61-67
26075038-7	2015	NAD(H) depletion in primary astrocytes was prevented by pretreatment with 1 muM of lycopene for 3.5 hours.	Lycopene	83-91	latexin	Homo sapiens	76-79
26075038-8	2015	Unexpectedly, in U251 cells lycopene treatment at concentrations &gt;= 5 muM resulted in significant reductions in [NAD(H)].	Lycopene	28-36	latexin	Homo sapiens	73-76
25293877-2	2014	We recently showed that apo-10"-lycopenoic acid, a lycopene metabolite generated by beta-carotene-9",10"-oxygenase (BCO2), inhibited carcinogen-initiated, high-fat diet (HFD)-promoted liver inflammation, and hepatic tumorigenesis development.	Lycopene	51-59	beta-carotene oxygenase 2	Mus musculus	116-120
25293877-7	2014	Lycopene supplementation in BCO2-KO mice suppressed oncogenic signals, including Met mRNA, beta-catenin protein, and mTOR complex 1 activation, which was associated with increased hepatic microRNA (miR)-199a/b and miR214 levels.	Lycopene	0-8	beta-carotene oxygenase 2	Mus musculus	28-32
25315431-0	2014	Dietary tomato and lycopene impact androgen signaling- and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis.	Lycopene	19-27	translocating chain-associating membrane protein 1	Mus musculus	111-116
25293877-5	2014	Intriguingly, lycopene chemopreventive effects in wild-type mice were associated with reduced hepatic proinflammatory signaling (phosphorylation of NK-kappaB p65 and STAT3; IL6 protein) and inflammatory foci.	Lycopene	14-22	signal transducer and activator of transcription 3	Mus musculus	166-171
25293877-7	2014	Lycopene supplementation in BCO2-KO mice suppressed oncogenic signals, including Met mRNA, beta-catenin protein, and mTOR complex 1 activation, which was associated with increased hepatic microRNA (miR)-199a/b and miR214 levels.	Lycopene	0-8	mechanistic target of rapamycin kinase	Mus musculus	117-121
25293877-5	2014	Intriguingly, lycopene chemopreventive effects in wild-type mice were associated with reduced hepatic proinflammatory signaling (phosphorylation of NK-kappaB p65 and STAT3; IL6 protein) and inflammatory foci.	Lycopene	14-22	interleukin 6	Mus musculus	173-176
25293877-7	2014	Lycopene supplementation in BCO2-KO mice suppressed oncogenic signals, including Met mRNA, beta-catenin protein, and mTOR complex 1 activation, which was associated with increased hepatic microRNA (miR)-199a/b and miR214 levels.	Lycopene	0-8	microRNA 615	Mus musculus	198-201
25293877-6	2014	In contrast, the protective effects of lycopene in BCO2-KO but not in wild-type mice were associated with reduced hepatic endoplasmic reticulum stress-mediated unfolded protein response (ER(UPR)), through decreasing ER(UPR)-mediated protein kinase RNA-activated like kinase-eukaryotic initiation factor 2alpha activation, and inositol requiring 1alpha-X-box-binding protein 1 signaling.	Lycopene	39-47	beta-carotene oxygenase 2	Mus musculus	51-55
25039074-8	2014	Silencing SlNCED1 or SlCYP707A2 by VIGS significantly altered the transcripts of a set of both ABA-responsive and ripening-related genes, including ABA-signalling genes (PYL1, PP2C1, and SnRK2.2), lycopene-synthesis genes (SlBcyc, SlPSY1 and SlPDS), and cell wall-degrading genes (SlPG1, SlEXP, and SlXET) during ripening.	Lycopene	197-205	abscisic acid 8'-hydroxylase 1	Solanum lycopersicum	21-31
25293877-7	2014	Lycopene supplementation in BCO2-KO mice suppressed oncogenic signals, including Met mRNA, beta-catenin protein, and mTOR complex 1 activation, which was associated with increased hepatic microRNA (miR)-199a/b and miR214 levels.	Lycopene	0-8	microRNA 214	Mus musculus	214-220
25293877-8	2014	These results provided novel experimental evidence that dietary lycopene can prevent HFD-promoted HCC incidence and multiplicity in mice, and may elicit different mechanisms depending on BCO2 expression.	Lycopene	64-72	beta-carotene oxygenase 2	Mus musculus	187-191
25383746-0	2014	Lycopene supplementation reduces TNF-alpha via RAGE in the kidney of obese rats.	Lycopene	0-8	tumor necrosis factor	Rattus norvegicus	33-42
25073513-0	2014	Effect of lycopene isolated from Chlorella marina on proliferation and apoptosis in human prostate cancer cell line PC-3.	Lycopene	10-18	chromobox 8	Homo sapiens	116-120
25066110-0	2014	Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in beta-amyloid induced Alzheimer s disease.	Lycopene	24-32	brain-derived neurotrophic factor	Rattus norvegicus	77-81
25066110-9	2014	Chronic administration of lycopene resulted in an improvement in memory retention, attenuation of mitochondrial-oxidative damage, reduced neuro-inflammation and restoration of BDNF level in beta-A1-42 treated rats.	Lycopene	26-34	brain-derived neurotrophic factor	Rattus norvegicus	176-180
25110555-12	2014	Moreover, lycopene blocked phosphorylation of p38 MAPK in EPCs (P &lt; 0.05).	Lycopene	10-18	mitogen-activated protein kinase 14	Homo sapiens	46-54
25141990-5	2014	Among the tested carotenoids, lycopene (IC(50) = 0.24 +- 0.05 muM) was the most efficient to prevent the hemolysis, followed by beta-carotene (0.32 +- 0.02 muM), lutein (0.38 +- 0.02 muM), and zeaxanthin (0.43 +- 0.02 muM).	Lycopene	30-38	latexin	Homo sapiens	62-65
25141990-5	2014	Among the tested carotenoids, lycopene (IC(50) = 0.24 +- 0.05 muM) was the most efficient to prevent the hemolysis, followed by beta-carotene (0.32 +- 0.02 muM), lutein (0.38 +- 0.02 muM), and zeaxanthin (0.43 +- 0.02 muM).	Lycopene	30-38	latexin	Homo sapiens	156-159
25141990-5	2014	Among the tested carotenoids, lycopene (IC(50) = 0.24 +- 0.05 muM) was the most efficient to prevent the hemolysis, followed by beta-carotene (0.32 +- 0.02 muM), lutein (0.38 +- 0.02 muM), and zeaxanthin (0.43 +- 0.02 muM).	Lycopene	30-38	latexin	Homo sapiens	156-159
25141990-5	2014	Among the tested carotenoids, lycopene (IC(50) = 0.24 +- 0.05 muM) was the most efficient to prevent the hemolysis, followed by beta-carotene (0.32 +- 0.02 muM), lutein (0.38 +- 0.02 muM), and zeaxanthin (0.43 +- 0.02 muM).	Lycopene	30-38	latexin	Homo sapiens	156-159
25153631-1	2014	Lycopene epsilon-cyclase (epsilon-LCY) is a key enzyme that catalyzes the synthesis of alpha-branch carotenoids through the cyclization of lycopene.	Lycopene	139-147	lycopene epsilon cyclase, chloroplastic	Nicotiana tabacum	0-37
25110555-16	2014	Further, the underlying molecular mechanism of the protective effects of lycopene against HG-induced EPC injury may involve the p38 MAPK signal transduction pathway.	Lycopene	73-81	mitogen-activated protein kinase 14	Homo sapiens	128-131
25110555-17	2014	Specifically, lycopene was shown to inhibit HG-induced EPC injury by inhibiting p38 MAPKs.	Lycopene	14-22	mitogen-activated protein kinase 14	Homo sapiens	80-83
25197372-9	2014	Administration of lycopene decreased the levels of MDA content and expression of CTGF, increased Akt/PKB phosphorylation and SOD activity in diabetic renal tissues.	Lycopene	18-26	cellular communication network factor 2	Rattus norvegicus	81-85
24781038-8	2014	Furthermore, mice that were administered lycopene exhibited higher levels of translocation of nuclear-factor-erythroid-2-related factor 2 into the nucleus compared with the vehicle-treated and model mice.	Lycopene	41-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	94-137
25197372-9	2014	Administration of lycopene decreased the levels of MDA content and expression of CTGF, increased Akt/PKB phosphorylation and SOD activity in diabetic renal tissues.	Lycopene	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
25197372-9	2014	Administration of lycopene decreased the levels of MDA content and expression of CTGF, increased Akt/PKB phosphorylation and SOD activity in diabetic renal tissues.	Lycopene	18-26	AKT serine/threonine kinase 1	Rattus norvegicus	101-104
25197372-10	2014	CONCLUSIONS: Lycopene protects against development of diabetic nephropathy and ameliorates renal function via improving oxidative status and regulating p-Akt and CTGF.	Lycopene	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	154-157
25197372-10	2014	CONCLUSIONS: Lycopene protects against development of diabetic nephropathy and ameliorates renal function via improving oxidative status and regulating p-Akt and CTGF.	Lycopene	13-21	cellular communication network factor 2	Rattus norvegicus	162-166
24985027-8	2014	beta-cryptoxanthin (P=0.04) and lycopene (P=0.02) inversely correlated with CSF and plasma IL-6 respectively.	Lycopene	32-40	interleukin 6	Homo sapiens	91-95
25004019-0	2014	Retraction: Lycopene inhibits NF-kB-mediated IL-8 expression and changes redox and PPARgamma signalling in cigarette smoke-stimulated macrophages.	Lycopene	12-20	peroxisome proliferator activated receptor gamma	Homo sapiens	83-92
25076850-7	2014	RESULTS: 24 hour incubation of prostate cell lines with 1.15micromol/l lycopene showed a 40% reduction of cellular motility in case of PC3 cells, 58% in DU145 cells and no effect was observed for PNT2 cells.	Lycopene	71-79	chromobox 8	Homo sapiens	135-138
25076850-8	2014	A dose related inhibition of cell adhesion to a basement membrane in the form of Matrigel  was observed in all three cell lines and it reached statistical significance for PC3 and PNT2 cells at lycopene concentrations &gt;=1.15micromol/l.	Lycopene	194-202	chromobox 8	Homo sapiens	172-175
24554029-4	2014	Western blot and FQRT-PCR analysis showed that Lycopene decreased pERK and extracellular signal-regulated kinase (ERK) protein and mRNA expression in a dose-dependent manner.	Lycopene	47-55	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	66-70
24831707-5	2014	NDPS1 transgenic fruits produced NPP-derived monoterpenes, including nerol, neral and geranial, while displaying reduced lycopene content.	Lycopene	121-129	dimethylallylcistransferase CPT1, chloroplastic	Solanum lycopersicum	0-5
24831707-7	2014	Unexpectedly, PHS1xNDPS1 fruits showed recovery of lycopene levels compared to NDPS1 fruits, suggesting that redirection of metabolic flux is only partially responsible for the reduction in carotenoids.	Lycopene	51-59	beta-phellandrene synthase (neryl-diphosphate-cyclizing), chloroplastic	Solanum lycopersicum	14-24
24831707-7	2014	Unexpectedly, PHS1xNDPS1 fruits showed recovery of lycopene levels compared to NDPS1 fruits, suggesting that redirection of metabolic flux is only partially responsible for the reduction in carotenoids.	Lycopene	51-59	dimethylallylcistransferase CPT1, chloroplastic	Solanum lycopersicum	19-24
24831707-8	2014	In vitro assays demonstrated that NPP serves as an inhibitor of geranylgeranyl diphosphate synthase, thus its consumption by PHS1 leads to recovery of lycopene levels.	Lycopene	151-159	beta-phellandrene synthase (neryl-diphosphate-cyclizing), chloroplastic	Solanum lycopersicum	125-129
24943973-10	2014	Further investigation revealed that lycopene could activate phosphoinositide-3 kinase (PI3K)/Akt.	Lycopene	36-44	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	60-85
24943973-10	2014	Further investigation revealed that lycopene could activate phosphoinositide-3 kinase (PI3K)/Akt.	Lycopene	36-44	thymoma viral proto-oncogene 1	Mus musculus	93-96
24943973-11	2014	Pretreatment with PI3K/Akt inhibitors prevented the protective effect of lycopene on MSCs.	Lycopene	73-81	thymoma viral proto-oncogene 1	Mus musculus	23-26
24554029-4	2014	Western blot and FQRT-PCR analysis showed that Lycopene decreased pERK and extracellular signal-regulated kinase (ERK) protein and mRNA expression in a dose-dependent manner.	Lycopene	47-55	mitogen-activated protein kinase 1	Homo sapiens	67-70
24554029-5	2014	These findings demonstrate that Lycopene inhibited gastric cancer HGC-27 cells growth and stimulated its apoptosis via the suppressing ERK signaling pathway.	Lycopene	32-40	mitogen-activated protein kinase 1	Homo sapiens	135-138
24554029-4	2014	Western blot and FQRT-PCR analysis showed that Lycopene decreased pERK and extracellular signal-regulated kinase (ERK) protein and mRNA expression in a dose-dependent manner.	Lycopene	47-55	mitogen-activated protein kinase 1	Homo sapiens	75-112
26417268-9	2014	Interestingly, dietary vitamin C (p = 0.001), tocopherols (p = 0.009) and lycopene (p = 0.038) were positively associated with ARE activity and showed an inverse correlation (p = 0.004, p = 0.029 and p = 0.021, respectively) with the methylation of some selected CpG sites of the PON1 gene.	Lycopene	74-82	paraoxonase 1	Homo sapiens	280-284
24213878-0	2014	Protective effect of lycopene on cardiac function and myocardial fibrosis after acute myocardial infarction in rats via the modulation of p38 and MMP-9.	Lycopene	21-29	mitogen activated protein kinase 14	Rattus norvegicus	138-141
24531880-4	2014	However, administration of lycopene in combination with cisplatin resulted in a reduction in the serum urea-N (124.3 vs. 62.4) and creatinine (1.37 vs. 0.40) levels and the kidney efflux transporters MRP2 and MRP4 proteins in the kidneys.	Lycopene	27-35	ATP binding cassette subfamily C member 2	Rattus norvegicus	200-204
24531880-4	2014	However, administration of lycopene in combination with cisplatin resulted in a reduction in the serum urea-N (124.3 vs. 62.4) and creatinine (1.37 vs. 0.40) levels and the kidney efflux transporters MRP2 and MRP4 proteins in the kidneys.	Lycopene	27-35	ATP binding cassette subfamily C member 4	Rattus norvegicus	209-213
24531880-5	2014	Administration of lycopene to acute renal injury-induced rats largely upregulated the organic anion transporters (OAT1 and 3) and organic cation transporters (OCT1 and 2) to decrease the side effects of cisplatin.	Lycopene	18-26	solute carrier family 22 member 6	Rattus norvegicus	114-124
24531880-5	2014	Administration of lycopene to acute renal injury-induced rats largely upregulated the organic anion transporters (OAT1 and 3) and organic cation transporters (OCT1 and 2) to decrease the side effects of cisplatin.	Lycopene	18-26	solute carrier family 22 member 1	Rattus norvegicus	159-169
24397737-6	2014	Lycopene induced strong and sustained activation of the ERK1/2, with concomitant cyclin D1 suppression and p21 upregulation in these three cell lines.	Lycopene	0-8	mitogen-activated protein kinase 3	Homo sapiens	56-62
24397737-6	2014	Lycopene induced strong and sustained activation of the ERK1/2, with concomitant cyclin D1 suppression and p21 upregulation in these three cell lines.	Lycopene	0-8	cyclin D1	Homo sapiens	81-90
24397737-6	2014	Lycopene induced strong and sustained activation of the ERK1/2, with concomitant cyclin D1 suppression and p21 upregulation in these three cell lines.	Lycopene	0-8	H3 histone pseudogene 16	Homo sapiens	107-110
24397737-7	2014	In triple negative cells, lycopene inhibited the phosphorylation of Akt and its downstream molecule mTOR, followed by subsequent upregulation of proapoptotic Bax without affecting anti-apoptotic Bcl-xL.	Lycopene	26-34	AKT serine/threonine kinase 1	Homo sapiens	68-71
24397737-7	2014	In triple negative cells, lycopene inhibited the phosphorylation of Akt and its downstream molecule mTOR, followed by subsequent upregulation of proapoptotic Bax without affecting anti-apoptotic Bcl-xL.	Lycopene	26-34	mechanistic target of rapamycin kinase	Homo sapiens	100-104
24397737-7	2014	In triple negative cells, lycopene inhibited the phosphorylation of Akt and its downstream molecule mTOR, followed by subsequent upregulation of proapoptotic Bax without affecting anti-apoptotic Bcl-xL.	Lycopene	26-34	BCL2 associated X, apoptosis regulator	Homo sapiens	158-161
24680933-0	2014	Efficient production of lycopene in Saccharomyces cerevisiae by expression of synthetic crt genes from a plasmid harboring the ADH2 promoter.	Lycopene	24-32	alcohol dehydrogenase ADH2	Saccharomyces cerevisiae S288C	127-131
24680933-7	2014	These results suggest the excellence of using the synthetic crt genes and the ADH2 promoter in generation of recombinant S. cerevisiae that produces a high level of lycopene.	Lycopene	165-173	alcohol dehydrogenase ADH2	Saccharomyces cerevisiae S288C	78-82
24323485-9	2014	Indeed, lycopene (1 muM) led to a further 2.5-fold rise in the UVA-induced HO-1 expression.	Lycopene	8-16	heme oxygenase 1	Solanum lycopersicum	75-79
24486304-4	2014	KEY FINDINGS: When tBHP was used to induce lipid peroxidation, lycopene was the most efficient carotenoid (IC50=2.2 +- 0.4 muM), while lutein was the most efficient (IC50=2.5 +- 0.7 muM) when peroxyl radicals (ROO) were generated by AAPH.	Lycopene	63-71	latexin	Homo sapiens	123-126
24486304-4	2014	KEY FINDINGS: When tBHP was used to induce lipid peroxidation, lycopene was the most efficient carotenoid (IC50=2.2 +- 0.4 muM), while lutein was the most efficient (IC50=2.5 +- 0.7 muM) when peroxyl radicals (ROO) were generated by AAPH.	Lycopene	63-71	latexin	Homo sapiens	182-185
26328145-17	2014	The mean CAT levels in the control group were higher than in the lycopene group (p&gt;0.05).	Lycopene	65-73	catalase	Rattus norvegicus	9-12
24213878-0	2014	Protective effect of lycopene on cardiac function and myocardial fibrosis after acute myocardial infarction in rats via the modulation of p38 and MMP-9.	Lycopene	21-29	matrix metallopeptidase 9	Rattus norvegicus	146-151
24213878-9	2014	Lycopene attenuated the MI-induced increase in MMP-9 and type I collagen expression, and inhibited p38 activation.	Lycopene	0-8	matrix metallopeptidase 9	Rattus norvegicus	47-72
24213878-9	2014	Lycopene attenuated the MI-induced increase in MMP-9 and type I collagen expression, and inhibited p38 activation.	Lycopene	0-8	mitogen activated protein kinase 14	Rattus norvegicus	99-102
24213878-11	2014	The data indicated that lycopene improved the cardiac function and ventricular remodeling by inhibiting p38 activation and MMP-9 expression.	Lycopene	24-32	mitogen activated protein kinase 14	Rattus norvegicus	104-107
24213878-11	2014	The data indicated that lycopene improved the cardiac function and ventricular remodeling by inhibiting p38 activation and MMP-9 expression.	Lycopene	24-32	matrix metallopeptidase 9	Rattus norvegicus	123-128
24219141-8	2014	Lycopene treatment led to a 4.2 (p &lt; 0.03) and a 4.6 (p &lt; 0.05) fold decrease in VEGF mRNA levels, in normal peritoneal and adhesion fibroblasts, respectively.	Lycopene	0-8	vascular endothelial growth factor A	Homo sapiens	87-91
24890168-0	2014	Lycopene can reduce prostate-specific antigen velocity in a phase II clinical study in Chinese population.	Lycopene	0-8	kallikrein related peptidase 3	Homo sapiens	20-45
24219141-9	2014	Lycopene treatment led to a 7.0 fold decrease in TGF-beta1 mRNA levels, in adhesion fibroblasts (p &lt; 0.03).	Lycopene	0-8	transforming growth factor beta 1	Homo sapiens	49-58
24851879-0	2014	The effect of lycopene on the PI3K/Akt signalling pathway in prostate cancer.	Lycopene	14-22	AKT serine/threonine kinase 1	Homo sapiens	35-38
24851879-8	2014	In this review, the effect of lycopene on PI3K/Akt pathway is summarised, which could be one of major mechanisms for anti-cancer activity of lycopene.	Lycopene	30-38	AKT serine/threonine kinase 1	Homo sapiens	47-50
24851879-8	2014	In this review, the effect of lycopene on PI3K/Akt pathway is summarised, which could be one of major mechanisms for anti-cancer activity of lycopene.	Lycopene	141-149	AKT serine/threonine kinase 1	Homo sapiens	47-50
24890168-3	2014	We investigated the effect of whole-tomato supplement lycopene on the prostate-specific antigen velocity in selected prostate cancer patients.	Lycopene	54-62	kallikrein related peptidase 3	Homo sapiens	70-95
24890168-18	2014	CONCLUSION: Administration of lycopene was able to reduce PSA velocity in this study group.	Lycopene	30-38	kallikrein related peptidase 3	Homo sapiens	58-61
25487946-11	2014	However, lycopene significantly increased GSH, CAT, GPx and SOD levels but decreased formation of TBARS production and NO in rats with priapism.	Lycopene	9-17	catalase	Rattus norvegicus	47-50
25089049-11	2014	In our study, the highest retention parameters for lutein, lycopene and beta-carotene were observed for C30 and C18 stationary phase.	Lycopene	59-67	Bardet-Biedl syndrome 9	Homo sapiens	112-115
24971153-0	2014	Lycopene Inhibits Urotensin-II-Induced Cardiomyocyte Hypertrophy in Neonatal Rat Cardiomyocytes.	Lycopene	0-8	urotensin 2	Rattus norvegicus	18-30
24971153-1	2014	This study investigated how lycopene affected urotensin-II- (U-II-) induced cardiomyocyte hypertrophy and the possible implicated mechanisms.	Lycopene	28-36	urotensin 2	Rattus norvegicus	46-58
24971153-1	2014	This study investigated how lycopene affected urotensin-II- (U-II-) induced cardiomyocyte hypertrophy and the possible implicated mechanisms.	Lycopene	28-36	urotensin 2	Rattus norvegicus	61-66
24971153-3	2014	The lycopene (3-10  mu M) pretreatment significantly inhibited the U-II-induced cardiomyocyte hypertrophy, decreased the production of U-II-induced reactive oxygen species (ROS), and reduced the level of NAD(P)H oxidase-4 expression.	Lycopene	4-12	urotensin 2	Rattus norvegicus	67-71
24971153-3	2014	The lycopene (3-10  mu M) pretreatment significantly inhibited the U-II-induced cardiomyocyte hypertrophy, decreased the production of U-II-induced reactive oxygen species (ROS), and reduced the level of NAD(P)H oxidase-4 expression.	Lycopene	4-12	urotensin 2	Rattus norvegicus	135-139
24971153-3	2014	The lycopene (3-10  mu M) pretreatment significantly inhibited the U-II-induced cardiomyocyte hypertrophy, decreased the production of U-II-induced reactive oxygen species (ROS), and reduced the level of NAD(P)H oxidase-4 expression.	Lycopene	4-12	NADPH oxidase 4	Rattus norvegicus	204-221
24971153-4	2014	Lycopene further inhibited the U-II-induced phosphorylation of the redox-sensitive extracellular signal-regulated kinases.	Lycopene	0-8	urotensin 2	Rattus norvegicus	31-35
24971153-5	2014	Moreover, lycopene treatment prevented the increase in the phosphorylation of serine-threonine kinase Akt and glycogen synthase kinase-3beta (GSK-3 beta ) caused by U-II without affecting the protein levels of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN).	Lycopene	10-18	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
24971153-5	2014	Moreover, lycopene treatment prevented the increase in the phosphorylation of serine-threonine kinase Akt and glycogen synthase kinase-3beta (GSK-3 beta ) caused by U-II without affecting the protein levels of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN).	Lycopene	10-18	glycogen synthase kinase 3 beta	Rattus norvegicus	110-140
24971153-5	2014	Moreover, lycopene treatment prevented the increase in the phosphorylation of serine-threonine kinase Akt and glycogen synthase kinase-3beta (GSK-3 beta ) caused by U-II without affecting the protein levels of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN).	Lycopene	10-18	glycogen synthase kinase 3 beta	Rattus norvegicus	142-152
24971153-5	2014	Moreover, lycopene treatment prevented the increase in the phosphorylation of serine-threonine kinase Akt and glycogen synthase kinase-3beta (GSK-3 beta ) caused by U-II without affecting the protein levels of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN).	Lycopene	10-18	urotensin 2	Rattus norvegicus	165-169
24971153-5	2014	Moreover, lycopene treatment prevented the increase in the phosphorylation of serine-threonine kinase Akt and glycogen synthase kinase-3beta (GSK-3 beta ) caused by U-II without affecting the protein levels of the phosphatase and tensin homolog deleted on chromosome 10 (PTEN).	Lycopene	10-18	phosphatase and tensin homolog	Rattus norvegicus	271-275
24971153-6	2014	However, lycopene increased the PTEN activity level, suggesting that lycopene prevents ROS-induced PTEN inactivation.	Lycopene	9-17	phosphatase and tensin homolog	Rattus norvegicus	32-36
24971153-6	2014	However, lycopene increased the PTEN activity level, suggesting that lycopene prevents ROS-induced PTEN inactivation.	Lycopene	69-77	phosphatase and tensin homolog	Rattus norvegicus	32-36
24971153-6	2014	However, lycopene increased the PTEN activity level, suggesting that lycopene prevents ROS-induced PTEN inactivation.	Lycopene	69-77	phosphatase and tensin homolog	Rattus norvegicus	99-103
24971153-7	2014	These findings imply that lycopene yields antihypertrophic effects that can prevent the activation of the Akt/GSK-3 beta hypertrophic pathway by modulating PTEN inactivation through U-II treatment.	Lycopene	26-34	AKT serine/threonine kinase 1	Rattus norvegicus	106-109
24971153-7	2014	These findings imply that lycopene yields antihypertrophic effects that can prevent the activation of the Akt/GSK-3 beta hypertrophic pathway by modulating PTEN inactivation through U-II treatment.	Lycopene	26-34	glycogen synthase kinase 3 beta	Rattus norvegicus	110-120
24971153-7	2014	These findings imply that lycopene yields antihypertrophic effects that can prevent the activation of the Akt/GSK-3 beta hypertrophic pathway by modulating PTEN inactivation through U-II treatment.	Lycopene	26-34	phosphatase and tensin homolog	Rattus norvegicus	156-160
24971153-7	2014	These findings imply that lycopene yields antihypertrophic effects that can prevent the activation of the Akt/GSK-3 beta hypertrophic pathway by modulating PTEN inactivation through U-II treatment.	Lycopene	26-34	urotensin 2	Rattus norvegicus	182-186
24971153-8	2014	Thus, the data indicate that lycopene prevented U-II-induced cardiomyocyte hypertrophy through a mechanism involving the inhibition of redox signaling.	Lycopene	29-37	urotensin 2	Rattus norvegicus	48-52
25389438-0	2014	The Effects of Lycopene on the Methylation of the GSTP1 Promoter and Global Methylation in Prostatic Cancer Cell Lines PC3 and LNCaP.	Lycopene	15-23	glutathione S-transferase pi 1	Homo sapiens	50-55
25389438-3	2014	However, it is unknown whether lycopene reactivates the tumor suppressor gene glutathioneS-transferase-pi (GSTP1) by demethylation of the hypermethylated CpGs that act to silence the GSTP1 promoter.	Lycopene	31-39	glutathione S-transferase pi 1	Homo sapiens	107-112
25389438-3	2014	However, it is unknown whether lycopene reactivates the tumor suppressor gene glutathioneS-transferase-pi (GSTP1) by demethylation of the hypermethylated CpGs that act to silence the GSTP1 promoter.	Lycopene	31-39	glutathione S-transferase pi 1	Homo sapiens	183-188
25389438-4	2014	Here, we demonstrated that lycopene treatment significantly decreased the methylation levels of the GSTP1 promoter and increased the mRNA and protein levels of GSTP1 in an androgen-independent PC-3 cell line.	Lycopene	27-35	glutathione S-transferase pi 1	Homo sapiens	100-105
25389438-4	2014	Here, we demonstrated that lycopene treatment significantly decreased the methylation levels of the GSTP1 promoter and increased the mRNA and protein levels of GSTP1 in an androgen-independent PC-3 cell line.	Lycopene	27-35	glutathione S-transferase pi 1	Homo sapiens	160-165
25389438-6	2014	DNA methyltransferase (DNMT) 3A protein levels were downregulated in PC-3 cells following lycopene treatment; however, DNMT1 and DNMT3B levels were unchanged.	Lycopene	90-98	DNA methyltransferase 3 alpha	Homo sapiens	0-31
24891766-0	2014	Lycopene modulates THP1 and Caco2 cells inflammatory state through transcriptional and nontranscriptional processes.	Lycopene	0-8	GLI family zinc finger 2	Homo sapiens	19-23
24891766-1	2014	We revisited the action of a carotenoid, the lycopene, on the expression of proinflammatory genes, reactive oxygen species (ROS) production, and metalloprotease (MMP9) activity.	Lycopene	45-53	matrix metallopeptidase 9	Homo sapiens	162-166
24891766-4	2014	In THP1 cells, short term pretreatment (2 h) with a low concentration (2 muM) of lycopene reinforce proinflammatory gene expression.	Lycopene	81-89	GLI family zinc finger 2	Homo sapiens	3-7
24891766-5	2014	The extent of the effect of lycopene is dependent on the proinflammtory stimulus (PMA, LPS or TNF) used.	Lycopene	28-36	tumor necrosis factor	Homo sapiens	94-97
24891766-6	2014	Lycopene enhanced MMP9 secretion via a c-AMP-dependent process, and reduced ROS production at higher concentrations than 2 muM.	Lycopene	0-8	matrix metallopeptidase 9	Homo sapiens	18-22
23906616-0	2014	Antineuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-alpha1/heme oxygenase-1 pathways.	Lycopene	33-41	heme oxygenase 1	Mus musculus	116-132
23906616-5	2014	In this study, we investigated the signaling pathways involved in lycopene-inhibited expression of cyclooxygenase (COX)-2 and inflammation mediators in BV-2 microglia, mouse primary cultured microglia, and rat primary cultured microglia.	Lycopene	66-74	cytochrome c oxidase II, mitochondrial	Mus musculus	99-121
23906616-10	2014	Interestingly, we also found that lycopene increased phospho-AMPKalpha1 accumulation in the nucleus in microglia.	Lycopene	34-42	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	61-71
23906616-11	2014	Preincubation of cells with HO-1 and AMPK selective pharmacological inhibitors dramatically reversed the inhibitory effect of lycopene on LPS-induced COX-2 and prostaglandin E2 production.	Lycopene	126-134	heme oxygenase 1	Mus musculus	28-32
23906616-6	2014	Lycopene inhibited the enhancement of lipopolysaccharide (LPS)-induced nuclear factor-kappaB (NF-kappaB) and activator protein 1 (AP-1) DNA binding activity.	Lycopene	0-8	jun proto-oncogene	Mus musculus	109-128
23906616-11	2014	Preincubation of cells with HO-1 and AMPK selective pharmacological inhibitors dramatically reversed the inhibitory effect of lycopene on LPS-induced COX-2 and prostaglandin E2 production.	Lycopene	126-134	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	37-41
23906616-11	2014	Preincubation of cells with HO-1 and AMPK selective pharmacological inhibitors dramatically reversed the inhibitory effect of lycopene on LPS-induced COX-2 and prostaglandin E2 production.	Lycopene	126-134	cytochrome c oxidase II, mitochondrial	Mus musculus	150-155
23906616-6	2014	Lycopene inhibited the enhancement of lipopolysaccharide (LPS)-induced nuclear factor-kappaB (NF-kappaB) and activator protein 1 (AP-1) DNA binding activity.	Lycopene	0-8	jun proto-oncogene	Mus musculus	130-134
23906616-12	2014	Transfection of microglia with HO-1 and AMPKalpha small interfering RNA (siRNA) also effectively reversed the inhibitory effect of lycopene on LPS-induced COX-2 expression.	Lycopene	131-139	heme oxygenase 1	Mus musculus	31-35
23906616-12	2014	Transfection of microglia with HO-1 and AMPKalpha small interfering RNA (siRNA) also effectively reversed the inhibitory effect of lycopene on LPS-induced COX-2 expression.	Lycopene	131-139	cytochrome c oxidase II, mitochondrial	Mus musculus	155-160
23906616-7	2014	In the present study, we demonstrated that lycopene inhibits LPS-induced COX-2 expression through heme oxygenase-1 (HO-1) activation.	Lycopene	43-51	cytochrome c oxidase II, mitochondrial	Mus musculus	73-78
23906616-14	2014	These findings suggest that lycopene-inhibited LPS-induced COX-2 expression is mediated by HO-1 activation through the AMPK pathway.	Lycopene	28-36	cytochrome c oxidase II, mitochondrial	Mus musculus	59-64
23906616-7	2014	In the present study, we demonstrated that lycopene inhibits LPS-induced COX-2 expression through heme oxygenase-1 (HO-1) activation.	Lycopene	43-51	heme oxygenase 1	Mus musculus	98-114
23906616-14	2014	These findings suggest that lycopene-inhibited LPS-induced COX-2 expression is mediated by HO-1 activation through the AMPK pathway.	Lycopene	28-36	heme oxygenase 1	Mus musculus	91-95
23906616-7	2014	In the present study, we demonstrated that lycopene inhibits LPS-induced COX-2 expression through heme oxygenase-1 (HO-1) activation.	Lycopene	43-51	heme oxygenase 1	Mus musculus	116-120
23906616-14	2014	These findings suggest that lycopene-inhibited LPS-induced COX-2 expression is mediated by HO-1 activation through the AMPK pathway.	Lycopene	28-36	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	119-123
23906616-8	2014	Our results also demonstrate that stimulation with lycopene increases the phosphorylation of liver kinase B1 (LKB1), calmodulin-dependent protein kinase II (CaMKII), and adenosine monophosphate-activated protein kinase (AMPK)-alpha1.	Lycopene	51-59	serine/threonine kinase 11	Mus musculus	93-108
23906616-8	2014	Our results also demonstrate that stimulation with lycopene increases the phosphorylation of liver kinase B1 (LKB1), calmodulin-dependent protein kinase II (CaMKII), and adenosine monophosphate-activated protein kinase (AMPK)-alpha1.	Lycopene	51-59	serine/threonine kinase 11	Mus musculus	110-114
23906616-8	2014	Our results also demonstrate that stimulation with lycopene increases the phosphorylation of liver kinase B1 (LKB1), calmodulin-dependent protein kinase II (CaMKII), and adenosine monophosphate-activated protein kinase (AMPK)-alpha1.	Lycopene	51-59	calcium/calmodulin-dependent protein kinase II alpha	Mus musculus	117-155
23906616-8	2014	Our results also demonstrate that stimulation with lycopene increases the phosphorylation of liver kinase B1 (LKB1), calmodulin-dependent protein kinase II (CaMKII), and adenosine monophosphate-activated protein kinase (AMPK)-alpha1.	Lycopene	51-59	calcium/calmodulin-dependent protein kinase II alpha	Mus musculus	157-163
23906616-8	2014	Our results also demonstrate that stimulation with lycopene increases the phosphorylation of liver kinase B1 (LKB1), calmodulin-dependent protein kinase II (CaMKII), and adenosine monophosphate-activated protein kinase (AMPK)-alpha1.	Lycopene	51-59	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	220-224
23906616-9	2014	Treatment with AMPK inhibitors effectively antagonized lycopene-stimulated HO-1 expression.	Lycopene	55-63	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mus musculus	15-19
23906616-9	2014	Treatment with AMPK inhibitors effectively antagonized lycopene-stimulated HO-1 expression.	Lycopene	55-63	heme oxygenase 1	Mus musculus	75-79
23749762-10	2014	Simultaneous supplementation of lycopene to PCBs-exposed rats resulted in significant decrease in the oxidative stress markers as that of control, while the AR, ERalpha, and ERbeta gene expressions were near to control.	Lycopene	32-40	estrogen receptor 1	Rattus norvegicus	161-168
24660901-0	2014	Orally administered lycopene attenuates diethylnitrosamine-induced hepatocarcinogenesis in rats by modulating Nrf-2/HO-1 and Akt/mTOR pathways.	Lycopene	20-28	NFE2 like bZIP transcription factor 2	Rattus norvegicus	110-115
24660901-0	2014	Orally administered lycopene attenuates diethylnitrosamine-induced hepatocarcinogenesis in rats by modulating Nrf-2/HO-1 and Akt/mTOR pathways.	Lycopene	20-28	heme oxygenase 1	Rattus norvegicus	116-120
24660901-0	2014	Orally administered lycopene attenuates diethylnitrosamine-induced hepatocarcinogenesis in rats by modulating Nrf-2/HO-1 and Akt/mTOR pathways.	Lycopene	20-28	AKT serine/threonine kinase 1	Rattus norvegicus	125-128
24660901-0	2014	Orally administered lycopene attenuates diethylnitrosamine-induced hepatocarcinogenesis in rats by modulating Nrf-2/HO-1 and Akt/mTOR pathways.	Lycopene	20-28	mechanistic target of rapamycin kinase	Rattus norvegicus	129-133
24660901-7	2014	Lycopene significantly reversed these biochemical changes and increased the expression of NF-E-2-related factor-2)/heme oxygenase-1, and it decreased NF-kappaB/cyclooxygenase-2, inhibiting the inflammatory cascade and activating antioxidant signaling (P &lt; 0.05).	Lycopene	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	90-113
24660901-7	2014	Lycopene significantly reversed these biochemical changes and increased the expression of NF-E-2-related factor-2)/heme oxygenase-1, and it decreased NF-kappaB/cyclooxygenase-2, inhibiting the inflammatory cascade and activating antioxidant signaling (P &lt; 0.05).	Lycopene	0-8	heme oxygenase 1	Rattus norvegicus	115-131
24660901-7	2014	Lycopene significantly reversed these biochemical changes and increased the expression of NF-E-2-related factor-2)/heme oxygenase-1, and it decreased NF-kappaB/cyclooxygenase-2, inhibiting the inflammatory cascade and activating antioxidant signaling (P &lt; 0.05).	Lycopene	0-8	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	160-176
24660901-8	2014	Lycopene also decreased DEN-induced increases in phosphorylated mammalian target of rapamycin (p-mTOR), phosphorylated p70 ribosomal protein S6 kinase 1, phosphorylated 4E-binding protein 1, and protein kinase B (P &lt; 0.05).	Lycopene	0-8	mechanistic target of rapamycin kinase	Homo sapiens	64-93
24660901-8	2014	Lycopene also decreased DEN-induced increases in phosphorylated mammalian target of rapamycin (p-mTOR), phosphorylated p70 ribosomal protein S6 kinase 1, phosphorylated 4E-binding protein 1, and protein kinase B (P &lt; 0.05).	Lycopene	0-8	mechanistic target of rapamycin kinase	Homo sapiens	97-101
24660901-8	2014	Lycopene also decreased DEN-induced increases in phosphorylated mammalian target of rapamycin (p-mTOR), phosphorylated p70 ribosomal protein S6 kinase 1, phosphorylated 4E-binding protein 1, and protein kinase B (P &lt; 0.05).	Lycopene	0-8	protein tyrosine kinase 2 beta	Homo sapiens	195-211
24660901-9	2014	Lycopene is an active chemopreventive agent that offers protection against DEN-induced hepatocarcinogenesis by inhibiting NF-kappaB and mTOR pathways.	Lycopene	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	136-140
23749762-10	2014	Simultaneous supplementation of lycopene to PCBs-exposed rats resulted in significant decrease in the oxidative stress markers as that of control, while the AR, ERalpha, and ERbeta gene expressions were near to control.	Lycopene	32-40	estrogen receptor 2	Rattus norvegicus	174-180
23973661-5	2013	Normally, pro-lycopene is further isomerized by CRTISO (carotenoid isomerase) to yield all-trans-lycopene, which is further cyclized to beta-carotene in melon fruit.	Lycopene	10-22	prolycopene isomerase, chloroplastic	Cucumis melo	48-54
24028090-2	2013	OBJECTIVE: This study explores the effect of lycopene against oxidative damage during experimental hepatitis, induced by D-galactosamine/lipopolysaccharide (D-GalN/LPS).	Lycopene	45-53	galanin and GMAP prepropeptide	Rattus norvegicus	159-163
24028090-3	2013	MATERIALS AND METHODS: Experimental rats were pretreated with lycopene intraperitoneally for 6 d (10 mg/kg body weight/day) and then induced by D-GalN/LPS.	Lycopene	62-70	galanin and GMAP prepropeptide	Rattus norvegicus	146-150
24028090-7	2013	RESULTS: The elevated level of lipid peroxides induced by D-GalN/LPS was significantly (p &lt; 0.05) reverted in lycopene pretreated animals.	Lycopene	113-121	galanin and GMAP prepropeptide	Rattus norvegicus	60-64
24028090-8	2013	Lycopene administration restored (p &lt; 0.05) the decreased activities of enzymatic and nonenzymatic antioxidant markers during D-GalN/LPS induction.	Lycopene	0-8	galanin and GMAP prepropeptide	Rattus norvegicus	131-135
24028090-9	2013	The DNA strand breaks (72.3 muM) generated during d-GalN/LPS toxic injury was significantly reduced (35.5 muM) upon pretreatment with lycopene as observed by reduced tail movement in comet assay.	Lycopene	134-142	galanin and GMAP prepropeptide	Rattus norvegicus	52-56
24187135-9	2013	Surprisingly, BCO1 catalyzed the oxidative cleavage of lycopene to yield acycloretinal with a catalytic efficiency similar to that of beta-carotene.	Lycopene	55-63	beta-carotene oxygenase 1	Homo sapiens	14-18
23973661-5	2013	Normally, pro-lycopene is further isomerized by CRTISO (carotenoid isomerase) to yield all-trans-lycopene, which is further cyclized to beta-carotene in melon fruit.	Lycopene	10-22	prolycopene isomerase, chloroplastic	Cucumis melo	56-76
23973661-5	2013	Normally, pro-lycopene is further isomerized by CRTISO (carotenoid isomerase) to yield all-trans-lycopene, which is further cyclized to beta-carotene in melon fruit.	Lycopene	87-105	prolycopene isomerase, chloroplastic	Cucumis melo	48-54
23973661-5	2013	Normally, pro-lycopene is further isomerized by CRTISO (carotenoid isomerase) to yield all-trans-lycopene, which is further cyclized to beta-carotene in melon fruit.	Lycopene	87-105	prolycopene isomerase, chloroplastic	Cucumis melo	56-76
23632237-0	2013	Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats.	Lycopene	0-8	leptin	Rattus norvegicus	95-101
23632237-0	2013	Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats.	Lycopene	0-8	resistin	Rattus norvegicus	103-111
23632237-0	2013	Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats.	Lycopene	0-8	interleukin 6	Rattus norvegicus	116-120
23632237-9	2013	Although lycopene supplementation did not affect BW or adiposity, it significantly decreased leptin, resistin and IL-6 gene expression in epididymal adipose tissue and plasma concentrations.	Lycopene	9-17	leptin	Rattus norvegicus	93-99
23632237-9	2013	Although lycopene supplementation did not affect BW or adiposity, it significantly decreased leptin, resistin and IL-6 gene expression in epididymal adipose tissue and plasma concentrations.	Lycopene	9-17	resistin	Rattus norvegicus	101-109
23632237-9	2013	Although lycopene supplementation did not affect BW or adiposity, it significantly decreased leptin, resistin and IL-6 gene expression in epididymal adipose tissue and plasma concentrations.	Lycopene	9-17	interleukin 6	Rattus norvegicus	114-118
23632237-11	2013	Lycopene affects adipokines by reducing leptin, resistin and plasma IL-6 levels.	Lycopene	0-8	leptin	Rattus norvegicus	40-46
23632237-11	2013	Lycopene affects adipokines by reducing leptin, resistin and plasma IL-6 levels.	Lycopene	0-8	resistin	Rattus norvegicus	48-56
23632237-11	2013	Lycopene affects adipokines by reducing leptin, resistin and plasma IL-6 levels.	Lycopene	0-8	interleukin 6	Rattus norvegicus	68-72
23746934-4	2013	WST-1 assay showed that lycopene induces a biphasic effect on PC-3 cells with a modest increase in proliferation at 1-5 muM, no change at 10-25 muM and a decrease at 50-100 muM doses in culture.	Lycopene	24-32	latexin	Homo sapiens	144-147
23746934-4	2013	WST-1 assay showed that lycopene induces a biphasic effect on PC-3 cells with a modest increase in proliferation at 1-5 muM, no change at 10-25 muM and a decrease at 50-100 muM doses in culture.	Lycopene	24-32	latexin	Homo sapiens	144-147
23746934-4	2013	WST-1 assay showed that lycopene induces a biphasic effect on PC-3 cells with a modest increase in proliferation at 1-5 muM, no change at 10-25 muM and a decrease at 50-100 muM doses in culture.	Lycopene	24-32	latexin	Homo sapiens	120-123
23746934-6	2013	Lycopene also augmented the anti-proliferative effect of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, but not Doxorubicin or Taxol, in prostate cancer.	Lycopene	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	57-105
23746934-6	2013	Lycopene also augmented the anti-proliferative effect of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, but not Doxorubicin or Taxol, in prostate cancer.	Lycopene	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	107-116
23746934-7	2013	Flow cytometry analyses showed that lycopene, in combination with chemotherapeutic agents and PPARgamma agonists, induced modest cell cycle arrest with significant increase in cell death by apoptosis and necrosis on prostate cancer.	Lycopene	36-44	peroxisome proliferator activated receptor gamma	Homo sapiens	94-103
24020124-0	2013	Lycopene protects against LPS-induced proinflammatory cytokine cascade in HUVECs.	Lycopene	0-8	interferon regulatory factor 6	Homo sapiens	26-29
24014574-1	2013	Lycopene biosynthesis in tomato (Solanum lycopersicum) fruits has been proposed to proceed through a poly-cis pathway catalyzed by phytoene synthase (PSY), two desaturases (phytoene desaturase [PDS] and zeta-carotene desaturase [ZDS]), and two cis-trans isomerases (zeta-carotene isomerase [ZISO] and prolycopene isomerase [CrtISO]).	Lycopene	0-8	zeta-carotene desaturase, chloroplastic/chromoplastic	Solanum lycopersicum	203-227
24014574-1	2013	Lycopene biosynthesis in tomato (Solanum lycopersicum) fruits has been proposed to proceed through a poly-cis pathway catalyzed by phytoene synthase (PSY), two desaturases (phytoene desaturase [PDS] and zeta-carotene desaturase [ZDS]), and two cis-trans isomerases (zeta-carotene isomerase [ZISO] and prolycopene isomerase [CrtISO]).	Lycopene	0-8	prolycopene isomerase, chloroplastic	Solanum lycopersicum	324-330
24014574-6	2013	Isomeric composition of fruits silenced at different metabolic steps suggested the existence of three functional units, comprising PSY1, PDS/ZISO, and ZDS/CrtISO, and responsible for the synthesis of 15-cis-phytoene, 9,9"-di-cis-zeta-carotene, and all-trans-lycopene, respectively.	Lycopene	248-266	prolycopene isomerase, chloroplastic	Solanum lycopersicum	155-161
24034573-7	2013	The diets did not modulate these genotypic perturbations, but lycopene and tomato powder significantly decreased serum insulin-like growth factor 1.	Lycopene	62-70	insulin-like growth factor 1	Mus musculus	119-147
23332503-7	2013	Lycopene supplementation with OTA increased GPx1 activity and GSH levels, and decreased apoptotic cell death in both cortex and medulla vs. control.	Lycopene	0-8	glutathione peroxidase 1	Rattus norvegicus	44-48
23008219-0	2013	Spectroscopic study of the interaction between lycopene and bovine serum albumin.	Lycopene	47-55	albumin	Homo sapiens	67-80
23008219-1	2013	The interaction of lycopene with bovine serum albumin (BSA) in aqueous solution was studied by fluorescence quenching, three-dimensional fluorescence and circular dichroism spectroscopy.	Lycopene	19-27	albumin	Homo sapiens	40-53
24228387-3	2013	Administration of lycopene (LycT) extracted from tomato to DOX treated mice showed a significant reduction in serum creatinine and urea levels which were associated with significantly low levels of LPO and significantly enhanced level of GSH and related antioxidant enzymes activity (GPx, GR and CAT) when compared to DOX group.	Lycopene	18-26	glutathione peroxidase	Solanum lycopersicum	284-287
24228387-3	2013	Administration of lycopene (LycT) extracted from tomato to DOX treated mice showed a significant reduction in serum creatinine and urea levels which were associated with significantly low levels of LPO and significantly enhanced level of GSH and related antioxidant enzymes activity (GPx, GR and CAT) when compared to DOX group.	Lycopene	18-26	catalase	Mus musculus	296-299
24020124-3	2013	The result showed that lycopene treatment significantly suppressed the response of HUVECs to LPS and reduced the levels of proinflammatory cytokines.	Lycopene	23-31	interferon regulatory factor 6	Homo sapiens	93-96
24020124-4	2013	Also, lycopene increased KLF2 expression, while it inhibited the activation TLR4 and its downstream ERK and the NF-kappaB signaling pathway in HUVECs.	Lycopene	6-14	Kruppel like factor 2	Homo sapiens	25-29
24020124-4	2013	Also, lycopene increased KLF2 expression, while it inhibited the activation TLR4 and its downstream ERK and the NF-kappaB signaling pathway in HUVECs.	Lycopene	6-14	toll like receptor 4	Homo sapiens	76-80
24020124-4	2013	Also, lycopene increased KLF2 expression, while it inhibited the activation TLR4 and its downstream ERK and the NF-kappaB signaling pathway in HUVECs.	Lycopene	6-14	mitogen-activated protein kinase 1	Homo sapiens	100-103
24020124-4	2013	Also, lycopene increased KLF2 expression, while it inhibited the activation TLR4 and its downstream ERK and the NF-kappaB signaling pathway in HUVECs.	Lycopene	6-14	nuclear factor kappa B subunit 1	Homo sapiens	112-121
23246157-2	2013	Since the assembly of Toll-like receptor 4 (TLR4) in lipid rafts is a key element in LPS induced signaling, we investigated whether this process would be influenced by lycopene.	Lycopene	168-176	toll-like receptor 4	Mus musculus	44-48
23035738-0	2013	Protective role of lycopene against Aroclor 1254-induced changes on GLUT4 in the skeletal muscles of adult male rat.	Lycopene	19-27	solute carrier family 2 member 4	Rattus norvegicus	68-73
24175569-7	2013	However, lycopene administration to the rotenone treated animals increased the activities of SOD, GSH-Px and CAT when compared to rotenone treated animals in substantia nigra and right striatum.	Lycopene	9-17	catalase	Mus musculus	109-112
24175569-9	2013	Along with this, the number of TH decreased, alpha-SYN increased and LC3-B positive neurons increased in rotenone administered animals, which were reversed on lycopene treatment.	Lycopene	159-167	microtubule-associated protein 1 light chain 3 beta	Mus musculus	69-74
23246157-0	2013	Lycopene suppresses proinflammatory response in lipopolysaccharide-stimulated macrophages by inhibiting ROS-induced trafficking of TLR4 to lipid raft-like domains.	Lycopene	0-8	toll-like receptor 4	Mus musculus	131-135
23246157-1	2013	We recently showed that lycopene inhibited lipopolysaccharide (LPS)-induced productions of nitric oxide (NO) and interleukin-6 (IL-6) in murine RAW264.7 macrophages by mechanisms related to inhibition of ERK and nuclear factor-kappaB.	Lycopene	24-32	interleukin 6	Mus musculus	113-126
23246157-1	2013	We recently showed that lycopene inhibited lipopolysaccharide (LPS)-induced productions of nitric oxide (NO) and interleukin-6 (IL-6) in murine RAW264.7 macrophages by mechanisms related to inhibition of ERK and nuclear factor-kappaB.	Lycopene	24-32	interleukin 6	Mus musculus	128-132
23246157-3	2013	We found that pretreatment of RAW264.7 cells with lycopene inhibited LPS-induced recruitment of TLR4 into fractions - enriched with lipid raft marker.	Lycopene	50-58	toll-like receptor 4	Mus musculus	96-100
23246157-4	2013	By the methods of immunoprecipitation and immunoblotting, we also found that lycopene inhibited the subsequent formation of the complex of TLR4 with its adaptors including myeloid differentiation primary-response protein 88 and TIR domain-containing adaptor-inducing IFN-beta.	Lycopene	77-85	toll-like receptor 4	Mus musculus	139-143
23246157-5	2013	We also found that the lycopene induced inhibition was associated with reduced formation of reactive oxygen species (ROS), which was an upstream mechanism for the effects of lycopene, because treating the cells with the antioxidant N-acetyl-l-cysteine and NADPH oxidase inhibitor diphenyleneiodonium chloride significantly inhibited LPS-induced recruitment of TLR4 into lipid raft-like domains as well as the production of proinflammatory molecule NO and IL-6.	Lycopene	23-31	toll-like receptor 4	Mus musculus	360-364
23246157-5	2013	We also found that the lycopene induced inhibition was associated with reduced formation of reactive oxygen species (ROS), which was an upstream mechanism for the effects of lycopene, because treating the cells with the antioxidant N-acetyl-l-cysteine and NADPH oxidase inhibitor diphenyleneiodonium chloride significantly inhibited LPS-induced recruitment of TLR4 into lipid raft-like domains as well as the production of proinflammatory molecule NO and IL-6.	Lycopene	23-31	interleukin 6	Mus musculus	455-459
23246157-5	2013	We also found that the lycopene induced inhibition was associated with reduced formation of reactive oxygen species (ROS), which was an upstream mechanism for the effects of lycopene, because treating the cells with the antioxidant N-acetyl-l-cysteine and NADPH oxidase inhibitor diphenyleneiodonium chloride significantly inhibited LPS-induced recruitment of TLR4 into lipid raft-like domains as well as the production of proinflammatory molecule NO and IL-6.	Lycopene	174-182	toll-like receptor 4	Mus musculus	360-364
23246157-5	2013	We also found that the lycopene induced inhibition was associated with reduced formation of reactive oxygen species (ROS), which was an upstream mechanism for the effects of lycopene, because treating the cells with the antioxidant N-acetyl-l-cysteine and NADPH oxidase inhibitor diphenyleneiodonium chloride significantly inhibited LPS-induced recruitment of TLR4 into lipid raft-like domains as well as the production of proinflammatory molecule NO and IL-6.	Lycopene	174-182	interleukin 6	Mus musculus	455-459
23246157-6	2013	Thus, our findings suggest that lycopene may prevent LPS-induced TLR4 assembly into lipid rafts through reducing intracellular ROS level.	Lycopene	32-40	toll-like receptor 4	Mus musculus	65-69
23667519-10	2013	These results show that lycopene and beta-carotene were able to negatively modulate events related to the malignant phenotype of AtT-20 cells, through a mechanism that could involve changes in the expression of connexin 43, Skp2 and p27(kip1); and suggest that these compounds might provide a novel pharmacological approach to the treatment of Cushing"s disease.	Lycopene	24-32	cyclin-dependent kinase inhibitor 1B	Mus musculus	233-236
23667519-10	2013	These results show that lycopene and beta-carotene were able to negatively modulate events related to the malignant phenotype of AtT-20 cells, through a mechanism that could involve changes in the expression of connexin 43, Skp2 and p27(kip1); and suggest that these compounds might provide a novel pharmacological approach to the treatment of Cushing"s disease.	Lycopene	24-32	cyclin-dependent kinase inhibitor 1B	Mus musculus	237-241
23667519-0	2013	Lycopene and beta-carotene induce growth inhibition and proapoptotic effects on ACTH-secreting pituitary adenoma cells.	Lycopene	0-8	pro-opiomelanocortin-alpha	Mus musculus	80-84
23483004-6	2013	Proteins that were most affected by lycopene were those involved in antioxidant responses, cytoprotection, apoptosis, growth inhibition, androgen receptor signaling, and the Akt/mTOR cascade.	Lycopene	36-44	AKT serine/threonine kinase 1	Homo sapiens	174-177
23667519-6	2013	Also, carotenoids induced apoptosis after 96 h. Lycopene and beta-carotene decreased the secretion of ACTH in AtT20 cells in a dose-dependent manner.	Lycopene	48-56	pro-opiomelanocortin-alpha	Mus musculus	102-106
23667519-10	2013	These results show that lycopene and beta-carotene were able to negatively modulate events related to the malignant phenotype of AtT-20 cells, through a mechanism that could involve changes in the expression of connexin 43, Skp2 and p27(kip1); and suggest that these compounds might provide a novel pharmacological approach to the treatment of Cushing"s disease.	Lycopene	24-32	gap junction protein, alpha 1	Mus musculus	211-222
23667519-10	2013	These results show that lycopene and beta-carotene were able to negatively modulate events related to the malignant phenotype of AtT-20 cells, through a mechanism that could involve changes in the expression of connexin 43, Skp2 and p27(kip1); and suggest that these compounds might provide a novel pharmacological approach to the treatment of Cushing"s disease.	Lycopene	24-32	S-phase kinase-associated protein 2	Mus musculus	224-228
23483004-6	2013	Proteins that were most affected by lycopene were those involved in antioxidant responses, cytoprotection, apoptosis, growth inhibition, androgen receptor signaling, and the Akt/mTOR cascade.	Lycopene	36-44	mechanistic target of rapamycin kinase	Homo sapiens	178-182
23431043-3	2013	Carotenoids, including lutein and lycopene, enhanced MMP-9 activity in RAW264.7 macrophages.	Lycopene	34-42	matrix metallopeptidase 9	Mus musculus	53-58
23060410-6	2013	However, pretreatment with LCP significantly (p &lt; 0.05) attenuated ISP-induced cardiac dysfunction as evidenced by improved SAP, DAP, MAP, HR, (+-)LVdP/dt and reduced LVEDP.	Lycopene	27-30	amyloid P component, serum	Rattus norvegicus	127-130
23060410-6	2013	However, pretreatment with LCP significantly (p &lt; 0.05) attenuated ISP-induced cardiac dysfunction as evidenced by improved SAP, DAP, MAP, HR, (+-)LVdP/dt and reduced LVEDP.	Lycopene	27-30	death-associated protein	Rattus norvegicus	132-135
23060410-7	2013	Pretreatment with LCP also significantly (p &lt; 0.05) prevented the depletion of antioxidants (SOD, CAT, GSHPx and GSH), myocyte injury marker enzymes (CK-MB and LDH) and inhibited lipid peroxidation and MDA formation in the heart.	Lycopene	18-21	catalase	Rattus norvegicus	101-104
23060410-7	2013	Pretreatment with LCP also significantly (p &lt; 0.05) prevented the depletion of antioxidants (SOD, CAT, GSHPx and GSH), myocyte injury marker enzymes (CK-MB and LDH) and inhibited lipid peroxidation and MDA formation in the heart.	Lycopene	18-21	glutathione peroxidase 1	Rattus norvegicus	106-111
23333602-0	2013	Study on the expression of c-Fos protein in the brain of rats after ingestion of food rich in lycopene.	Lycopene	94-102	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	27-32
23076637-8	2013	Lycopene was able to restore body weight, serum testosterone, StAR mRNA, TOC, NOx levels, and PARP activity with significant decrease in HSP-70 mRNA, and DNA damage.	Lycopene	0-8	steroidogenic acute regulatory protein	Rattus norvegicus	62-66
23076637-8	2013	Lycopene was able to restore body weight, serum testosterone, StAR mRNA, TOC, NOx levels, and PARP activity with significant decrease in HSP-70 mRNA, and DNA damage.	Lycopene	0-8	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	137-143
23406468-0	2013	A STAY-GREEN protein SlSGR1 regulates lycopene and beta-carotene accumulation by interacting directly with SlPSY1 during ripening processes in tomato.	Lycopene	38-46	senescence-inducible chloroplast stay-green protein 1	Solanum lycopersicum	21-27
23406468-0	2013	A STAY-GREEN protein SlSGR1 regulates lycopene and beta-carotene accumulation by interacting directly with SlPSY1 during ripening processes in tomato.	Lycopene	38-46	phytoene synthase 1, chloroplastic	Solanum lycopersicum	107-113
23406468-3	2013	We report that SlSGR1 can regulate tomato (Solanum lycopersicum) lycopene accumulation through direct interaction with a key carotenoid synthetic enzyme SlPSY1, and can inhibit its activity.	Lycopene	65-73	senescence-inducible chloroplast stay-green protein 1	Solanum lycopersicum	15-21
23406468-3	2013	We report that SlSGR1 can regulate tomato (Solanum lycopersicum) lycopene accumulation through direct interaction with a key carotenoid synthetic enzyme SlPSY1, and can inhibit its activity.	Lycopene	65-73	phytoene synthase 1, chloroplastic	Solanum lycopersicum	153-159
23406468-4	2013	This interaction with SlSGR1 mediates lycopene accumulation during tomato fruit maturation.	Lycopene	38-46	senescence-inducible chloroplast stay-green protein 1	Solanum lycopersicum	22-28
23406468-5	2013	We confirmed this inhibitory activity in bacteria engineered to produce lycopene, where the introduction of SlSGR1 reduced dramatically lycopene biosynthesis.	Lycopene	72-80	senescence-inducible chloroplast stay-green protein 1	Solanum lycopersicum	108-114
23406468-5	2013	We confirmed this inhibitory activity in bacteria engineered to produce lycopene, where the introduction of SlSGR1 reduced dramatically lycopene biosynthesis.	Lycopene	136-144	senescence-inducible chloroplast stay-green protein 1	Solanum lycopersicum	108-114
23406468-6	2013	The repression of SlSGR1 in transgenic tomato fruits resulted in altered accumulation patterns of phytoene and lycopene, whilst simultaneously elevating SlPSY1 mRNA accumulation and plastid conversion at the early stages of fruit ripening, resulting in increased lycopene and beta-carotene (four- and nine-fold, respectively) in red ripe fruits.	Lycopene	111-119	senescence-inducible chloroplast stay-green protein 1	Solanum lycopersicum	18-24
23406468-6	2013	The repression of SlSGR1 in transgenic tomato fruits resulted in altered accumulation patterns of phytoene and lycopene, whilst simultaneously elevating SlPSY1 mRNA accumulation and plastid conversion at the early stages of fruit ripening, resulting in increased lycopene and beta-carotene (four- and nine-fold, respectively) in red ripe fruits.	Lycopene	263-271	senescence-inducible chloroplast stay-green protein 1	Solanum lycopersicum	18-24
22718574-6	2013	Lycopene altered the expression levels of proteins such as Cytokeratin 8/18 (CK8/18), CK19 and their post translational status.	Lycopene	0-8	keratin 8	Homo sapiens	59-75
22718574-6	2013	Lycopene altered the expression levels of proteins such as Cytokeratin 8/18 (CK8/18), CK19 and their post translational status.	Lycopene	0-8	keratin 8	Homo sapiens	77-83
22718574-6	2013	Lycopene altered the expression levels of proteins such as Cytokeratin 8/18 (CK8/18), CK19 and their post translational status.	Lycopene	0-8	keratin 19	Homo sapiens	86-90
22718574-8	2013	Lycopene was shown to modulate cell cycle proteins such as beta tubulin, CK8/18, CK19 and heat shock proteins.	Lycopene	0-8	keratin 8	Homo sapiens	73-79
22718574-8	2013	Lycopene was shown to modulate cell cycle proteins such as beta tubulin, CK8/18, CK19 and heat shock proteins.	Lycopene	0-8	keratin 19	Homo sapiens	81-85
29220836-0	2013	Correction: Lycopene Inhibits NF-kB-Mediated IL-8 Expression and Changes Redox and PPARgamma Signalling in Cigarette Smoke-Stimulated Macrophages.	Lycopene	12-20	peroxisome proliferator activated receptor gamma	Homo sapiens	83-92
22704783-8	2013	These results demonstrate that lycopene has a potent anti-angiogenic effect and that these effect may be associated with its up-regulation of IL-12 and IFN-gamma.	Lycopene	31-39	interferon gamma	Homo sapiens	152-161
22704783-6	2013	We further examined the effects of lycopene stimulation on cytokine levels in MNC and showed that, as compared to the control, lycopene (10 mumol/L) significantly (P&lt;.001) up-regulated interleukin (IL)-12 by 163% and interferon (IFN)-gamma by 531%.	Lycopene	127-135	interferon gamma	Homo sapiens	220-242
23129580-0	2013	Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC.	Lycopene	0-8	hepatocyte nuclear factor 4 alpha	Homo sapiens	67-70
23129580-0	2013	Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC.	Lycopene	0-8	APC regulator of WNT signaling pathway	Homo sapiens	112-115
23129580-10	2013	Lycopene, a plant-derived antioxidant, synergistically increased QC activity and inhibited Wnt-TCF signaling in cancer cells without affecting the MCF-10A normal breast cell line.	Lycopene	0-8	hepatocyte nuclear factor 4 alpha	Homo sapiens	95-98
23347319-5	2013	Administration of lycopene at the dose of 2.5 mg/kg bw per day significantly reduced serum glucose, TC, TG, ALT, and AST levels, and increased serum insulin levels, but there were no improvements in food-water intake and body weight change parameters in lycopene-treated diabetic rats.	Lycopene	18-26	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	117-120
23859041-5	2013	DUSP genes interacted with carbohydrates, mutagen index, calories, calcium, vitamin D, lycopene, dietary fats, folic acid, and selenium.	Lycopene	87-95	dual specificity phosphatase 5	Homo sapiens	0-4
24283422-4	2013	Both sodium copper chlorophyllin (SCC) and lycopene in EEWS were identified by ultraperformance liquid chromatography-photodiode array-electrospray ionization-mass spectroscopy (UPLC-PDA-ESI-MS/MSn) as major components at m/z 722.64 and 535.45, respectively.	Lycopene	43-51	moesin	Homo sapiens	194-197
24053141-6	2013	Using real time PCR assay, lycopene also induced apoptosis in prostate cancer cells with altered gene expression of Bax and Bcl-2.	Lycopene	27-35	BCL2 associated X, apoptosis regulator	Homo sapiens	116-119
24053141-6	2013	Using real time PCR assay, lycopene also induced apoptosis in prostate cancer cells with altered gene expression of Bax and Bcl-2.	Lycopene	27-35	BCL2 apoptosis regulator	Homo sapiens	124-129
22989703-3	2013	In the present study, we evaluated and compared the antioxidant efficacy of the lycopene eccentric cleavage products apo-10"-lycopenoic acid and apo-14"-lycopenoic acid in counteracting the oxidative effects of H(2)O(2) and cigarette smoke extract (CSE) in THP-1 macrophages.	Lycopene	80-88	GLI family zinc finger 2	Homo sapiens	257-262
22819555-11	2013	Lycopene increased in serum and HDL(2&amp;3) following both lycopene interventions (P&lt;.001, for all), while SAA decreased in serum following the lycopene supplement and in HDL(3) following both lycopene interventions (P&lt;.05 for all).	Lycopene	148-156	serum amyloid A1 cluster	Homo sapiens	111-114
22819555-11	2013	Lycopene increased in serum and HDL(2&amp;3) following both lycopene interventions (P&lt;.001, for all), while SAA decreased in serum following the lycopene supplement and in HDL(3) following both lycopene interventions (P&lt;.05 for all).	Lycopene	148-156	serum amyloid A1 cluster	Homo sapiens	111-114
22819555-12	2013	PON-1 activity increased in serum and HDL(2&amp;3) in both lycopene groups (P&lt;.05, for all).	Lycopene	59-67	paraoxonase 1	Homo sapiens	0-5
22819555-13	2013	Furthermore, the activity of CETP decreased in serum following the lycopene supplement, while the activity of LCAT increased in serum and HDL(3) following both lycopene interventions (P&lt;.05 for all).	Lycopene	67-75	cholesteryl ester transfer protein	Homo sapiens	29-33
22819555-13	2013	Furthermore, the activity of CETP decreased in serum following the lycopene supplement, while the activity of LCAT increased in serum and HDL(3) following both lycopene interventions (P&lt;.05 for all).	Lycopene	160-168	lecithin-cholesterol acyltransferase	Homo sapiens	110-114
22819555-14	2013	These results demonstrate that in moderately overweight, middle-aged subjects, increasing lycopene intake leads to changes to HDL(2&amp;3), which we suggest enhanced their antiatherogenic properties.	Lycopene	90-98	junctophilin 3	Homo sapiens	126-137
22137263-0	2012	Lycopene and the LXRalpha agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARgamma-LXRalpha-ABCA1 pathway.	Lycopene	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	139-148
23053559-3	2012	In particular, the characterization and study of beta-carotene 9",10"-oxygenase has shown that this enzyme can catalyze the excentric cleavage of both provitamin and non-provitamin A carotenoids to form apo-10"-carotenoids, including apo-10"-lycopenoids from lycopene.	Lycopene	259-267	beta-carotene oxygenase 2	Homo sapiens	49-79
23593578-2	2012	METHODS: The efficacy of lycopene was validated during D-Gal/LPS induced hepatitis by analyzing the activity of lipid metabolizing enzymes such as lipoprotein lipase (LPL), lecithin-cholesterol acyl transferase (LCAT) and hepatic triglyceride lipase (HTGL).	Lycopene	25-33	lipoprotein lipase	Rattus norvegicus	147-165
23593578-2	2012	METHODS: The efficacy of lycopene was validated during D-Gal/LPS induced hepatitis by analyzing the activity of lipid metabolizing enzymes such as lipoprotein lipase (LPL), lecithin-cholesterol acyl transferase (LCAT) and hepatic triglyceride lipase (HTGL).	Lycopene	25-33	lipoprotein lipase	Rattus norvegicus	167-170
23593578-2	2012	METHODS: The efficacy of lycopene was validated during D-Gal/LPS induced hepatitis by analyzing the activity of lipid metabolizing enzymes such as lipoprotein lipase (LPL), lecithin-cholesterol acyl transferase (LCAT) and hepatic triglyceride lipase (HTGL).	Lycopene	25-33	lecithin cholesterol acyltransferase	Rattus norvegicus	173-210
23593578-2	2012	METHODS: The efficacy of lycopene was validated during D-Gal/LPS induced hepatitis by analyzing the activity of lipid metabolizing enzymes such as lipoprotein lipase (LPL), lecithin-cholesterol acyl transferase (LCAT) and hepatic triglyceride lipase (HTGL).	Lycopene	25-33	lecithin cholesterol acyltransferase	Rattus norvegicus	212-216
22978712-0	2012	Lycopene counteracts the hepatic response to 7,12-dimethylbenz[a]anthracene by altering the expression of Bax, Bcl-2, caspases, and oxidative stress biomarkers.	Lycopene	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	106-109
22978712-0	2012	Lycopene counteracts the hepatic response to 7,12-dimethylbenz[a]anthracene by altering the expression of Bax, Bcl-2, caspases, and oxidative stress biomarkers.	Lycopene	0-8	BCL2, apoptosis regulator	Rattus norvegicus	111-116
22978712-0	2012	Lycopene counteracts the hepatic response to 7,12-dimethylbenz[a]anthracene by altering the expression of Bax, Bcl-2, caspases, and oxidative stress biomarkers.	Lycopene	0-8	caspase 9	Rattus norvegicus	118-126
22978712-4	2012	OBJECTIVE: In this study, we report the effect of lycopene on 7,12-dimethylbenz[a]-anthracene (DMBA)-induced expression of Bax, Bcl-2, caspases, and oxidative stres biomarkers in the liver.	Lycopene	50-58	BCL2 associated X, apoptosis regulator	Rattus norvegicus	123-126
22978712-4	2012	OBJECTIVE: In this study, we report the effect of lycopene on 7,12-dimethylbenz[a]-anthracene (DMBA)-induced expression of Bax, Bcl-2, caspases, and oxidative stres biomarkers in the liver.	Lycopene	50-58	BCL2, apoptosis regulator	Rattus norvegicus	128-133
22978712-4	2012	OBJECTIVE: In this study, we report the effect of lycopene on 7,12-dimethylbenz[a]-anthracene (DMBA)-induced expression of Bax, Bcl-2, caspases, and oxidative stres biomarkers in the liver.	Lycopene	50-58	caspase 9	Rattus norvegicus	135-143
22978712-9	2012	Lycopene reversed the changes in the respective groups, and decreased the level of Bcl-2 to 25%, while increasing the Bax to 42% when compared to DMBA control.	Lycopene	0-8	BCL2, apoptosis regulator	Rattus norvegicus	83-88
22978712-9	2012	Lycopene reversed the changes in the respective groups, and decreased the level of Bcl-2 to 25%, while increasing the Bax to 42% when compared to DMBA control.	Lycopene	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	118-121
22978712-10	2012	Lycopene increased the expression of caspase-3 (82.09%) and caspase-9 (58.96%), and attenuated the level of hepatic malondialdehyde (41%) and 8-isoprostane (40%) when compared to the respective controls.	Lycopene	0-8	caspase 3	Rattus norvegicus	37-46
22978712-10	2012	Lycopene increased the expression of caspase-3 (82.09%) and caspase-9 (58.96%), and attenuated the level of hepatic malondialdehyde (41%) and 8-isoprostane (40%) when compared to the respective controls.	Lycopene	0-8	caspase 9	Rattus norvegicus	60-69
22978712-13	2012	CONCLUSION: The study reports that lycopene counteracts the hepatic response to DMBA by altering the expression of Bax, Bcl-2, caspases, and oxidative stress biomarkers in animal model.	Lycopene	35-43	BCL2 associated X, apoptosis regulator	Rattus norvegicus	115-118
22978712-13	2012	CONCLUSION: The study reports that lycopene counteracts the hepatic response to DMBA by altering the expression of Bax, Bcl-2, caspases, and oxidative stress biomarkers in animal model.	Lycopene	35-43	BCL2, apoptosis regulator	Rattus norvegicus	120-125
22978712-13	2012	CONCLUSION: The study reports that lycopene counteracts the hepatic response to DMBA by altering the expression of Bax, Bcl-2, caspases, and oxidative stress biomarkers in animal model.	Lycopene	35-43	caspase 9	Rattus norvegicus	127-135
22850611-10	2012	In contrast, zeaxanthin had a significant negative association with VCAM-1 (P=0.001) and apoE (P=0.022) .Lycopene was inversely associated with VCAM-1(P=0.011) and LDL (P=0.046).	Lycopene	105-113	vascular cell adhesion molecule 1	Homo sapiens	144-150
22968990-0	2012	Lycopene inhibits hepatic steatosis via microRNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet.	Lycopene	0-8	fatty acid binding protein 7, brain	Mus musculus	78-106
22968990-7	2012	Lycopene normalized the downregulation of miR-21, which led to the downregulation of fatty acid-binding protein 7 (FABP7), a direct target of miR-21, at both the transcriptional and translational levels.	Lycopene	0-8	microRNA 21a	Mus musculus	42-48
22968990-7	2012	Lycopene normalized the downregulation of miR-21, which led to the downregulation of fatty acid-binding protein 7 (FABP7), a direct target of miR-21, at both the transcriptional and translational levels.	Lycopene	0-8	fatty acid binding protein 7, brain	Mus musculus	85-113
22968990-7	2012	Lycopene normalized the downregulation of miR-21, which led to the downregulation of fatty acid-binding protein 7 (FABP7), a direct target of miR-21, at both the transcriptional and translational levels.	Lycopene	0-8	fatty acid binding protein 7, brain	Mus musculus	115-120
22968990-7	2012	Lycopene normalized the downregulation of miR-21, which led to the downregulation of fatty acid-binding protein 7 (FABP7), a direct target of miR-21, at both the transcriptional and translational levels.	Lycopene	0-8	microRNA 21a	Mus musculus	142-148
23136376-4	2012	Whereas the single lines only showed very mild alterations in fruit pigmentation, the double silenced lines exhibited an orange-ripe fruit phenotype due to highly reduced lycopene levels, suggesting that FUL1 and FUL2 have a redundant function in fruit ripening.	Lycopene	171-179	agamous-like MADS-box protein AGL8 homolog	Solanum lycopersicum	204-208
23136376-4	2012	Whereas the single lines only showed very mild alterations in fruit pigmentation, the double silenced lines exhibited an orange-ripe fruit phenotype due to highly reduced lycopene levels, suggesting that FUL1 and FUL2 have a redundant function in fruit ripening.	Lycopene	171-179	transcription factor FRUITFULL	Solanum lycopersicum	213-217
22152988-3	2012	The objective of the present study was to investigate whether lycopene and beta-carotene in micelles (M), at concentrations that could be reached via the diet (10-25 mug/ml) could aid in the reduction of TNF-alpha plus IL-1beta-induced inflammation of Caco-2 human epithelial cells.	Lycopene	62-70	tumor necrosis factor	Homo sapiens	204-213
22152988-3	2012	The objective of the present study was to investigate whether lycopene and beta-carotene in micelles (M), at concentrations that could be reached via the diet (10-25 mug/ml) could aid in the reduction of TNF-alpha plus IL-1beta-induced inflammation of Caco-2 human epithelial cells.	Lycopene	62-70	interleukin 1 beta	Homo sapiens	219-227
22152988-8	2012	Only one protein was differentially regulated by lycopene (profilin-1).	Lycopene	49-57	profilin 1	Homo sapiens	59-69
22356815-0	2012	Lycopene inhibits caspase-3 activity and reduces oxidative organ damage in a rat model of thermal injury.	Lycopene	0-8	caspase 3	Rattus norvegicus	18-27
22137263-0	2012	Lycopene and the LXRalpha agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARgamma-LXRalpha-ABCA1 pathway.	Lycopene	0-8	ATP binding cassette subfamily A member 1	Homo sapiens	158-163
22137263-1	2012	In our previous study, we demonstrated that lycopene can inhibit the proliferation of androgen-dependent prostate LNCaP cancer cells through the activation of the peroxisome proliferator-activated receptor gamma (PPARgamma)-liver X receptor alpha (LXRalpha)-ATP-binding cassette transporter 1 (ABCA1) pathway.	Lycopene	44-52	peroxisome proliferator activated receptor gamma	Homo sapiens	213-222
22137263-1	2012	In our previous study, we demonstrated that lycopene can inhibit the proliferation of androgen-dependent prostate LNCaP cancer cells through the activation of the peroxisome proliferator-activated receptor gamma (PPARgamma)-liver X receptor alpha (LXRalpha)-ATP-binding cassette transporter 1 (ABCA1) pathway.	Lycopene	44-52	nuclear receptor subfamily 1 group H member 3	Homo sapiens	248-256
22137263-1	2012	In our previous study, we demonstrated that lycopene can inhibit the proliferation of androgen-dependent prostate LNCaP cancer cells through the activation of the peroxisome proliferator-activated receptor gamma (PPARgamma)-liver X receptor alpha (LXRalpha)-ATP-binding cassette transporter 1 (ABCA1) pathway.	Lycopene	44-52	ATP binding cassette subfamily A member 1	Homo sapiens	294-299
22137263-4	2012	We show that lycopene significantly increased protein and mRNA expression of PPARgamma, LXRalpha and ABCA1 and cholesterol efflux (i.e., decreased cellular cholesterol and increased cholesterol in culture medium).	Lycopene	13-21	peroxisome proliferator activated receptor gamma	Homo sapiens	77-86
22137263-4	2012	We show that lycopene significantly increased protein and mRNA expression of PPARgamma, LXRalpha and ABCA1 and cholesterol efflux (i.e., decreased cellular cholesterol and increased cholesterol in culture medium).	Lycopene	13-21	nuclear receptor subfamily 1 group H member 3	Homo sapiens	88-96
22137263-4	2012	We show that lycopene significantly increased protein and mRNA expression of PPARgamma, LXRalpha and ABCA1 and cholesterol efflux (i.e., decreased cellular cholesterol and increased cholesterol in culture medium).	Lycopene	13-21	ATP binding cassette subfamily A member 1	Homo sapiens	101-106
22137263-5	2012	Lycopene (10 muM) in the presence of a specific antagonist of PPARgamma (GW9662) or of LXRalpha (GGPP) restored the proliferation of DU145 cells and significantly suppressed lycopene-induced protein and mRNA expression of PPARgamma and LXRalpha and cholesterol efflux.	Lycopene	0-8	latexin	Homo sapiens	13-16
22137263-5	2012	Lycopene (10 muM) in the presence of a specific antagonist of PPARgamma (GW9662) or of LXRalpha (GGPP) restored the proliferation of DU145 cells and significantly suppressed lycopene-induced protein and mRNA expression of PPARgamma and LXRalpha and cholesterol efflux.	Lycopene	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	62-71
22137263-0	2012	Lycopene and the LXRalpha agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARgamma-LXRalpha-ABCA1 pathway.	Lycopene	0-8	nuclear receptor subfamily 1 group H member 3	Homo sapiens	149-157
22760978-8	2012	Lycopene also significantly inhibited CD69 expression (by up to 12%) as well as IL-2 secretion (by up to 29%).	Lycopene	0-8	CD69 molecule	Homo sapiens	38-42
22137263-5	2012	Lycopene (10 muM) in the presence of a specific antagonist of PPARgamma (GW9662) or of LXRalpha (GGPP) restored the proliferation of DU145 cells and significantly suppressed lycopene-induced protein and mRNA expression of PPARgamma and LXRalpha and cholesterol efflux.	Lycopene	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	222-231
22137263-5	2012	Lycopene (10 muM) in the presence of a specific antagonist of PPARgamma (GW9662) or of LXRalpha (GGPP) restored the proliferation of DU145 cells and significantly suppressed lycopene-induced protein and mRNA expression of PPARgamma and LXRalpha and cholesterol efflux.	Lycopene	0-8	nuclear receptor subfamily 1 group H member 3	Homo sapiens	236-244
22137263-5	2012	Lycopene (10 muM) in the presence of a specific antagonist of PPARgamma (GW9662) or of LXRalpha (GGPP) restored the proliferation of DU145 cells and significantly suppressed lycopene-induced protein and mRNA expression of PPARgamma and LXRalpha and cholesterol efflux.	Lycopene	174-182	nuclear receptor subfamily 1 group H member 3	Homo sapiens	87-95
22137263-6	2012	Liver X receptor alpha knockdown by siRNA against LXRalpha significantly promoted the proliferation of DU145 cells, whereas si-LXRalpha knockdown followed by incubation with lycopene (10 muM) restored the proliferation to the control level.	Lycopene	174-182	latexin	Homo sapiens	187-190
22137263-7	2012	Furthermore, lycopene in combination with the LXRalpha agonist T0901317 exhibited synergistic effects on cell proliferation and protein expression of PPARgamma, LXRalpha and ABCA1.	Lycopene	13-21	peroxisome proliferator activated receptor gamma	Homo sapiens	150-159
22137263-7	2012	Furthermore, lycopene in combination with the LXRalpha agonist T0901317 exhibited synergistic effects on cell proliferation and protein expression of PPARgamma, LXRalpha and ABCA1.	Lycopene	13-21	nuclear receptor subfamily 1 group H member 3	Homo sapiens	161-169
22137263-7	2012	Furthermore, lycopene in combination with the LXRalpha agonist T0901317 exhibited synergistic effects on cell proliferation and protein expression of PPARgamma, LXRalpha and ABCA1.	Lycopene	13-21	ATP binding cassette subfamily A member 1	Homo sapiens	174-179
22137263-8	2012	These results demonstrate that lycopene can inhibit DU145 cell proliferation via PPARgamma-LXRalpha-ABCA1 pathway and that lycopene and T0901317 exhibit synergistic effects.	Lycopene	31-39	peroxisome proliferator activated receptor gamma	Homo sapiens	81-90
22137263-8	2012	These results demonstrate that lycopene can inhibit DU145 cell proliferation via PPARgamma-LXRalpha-ABCA1 pathway and that lycopene and T0901317 exhibit synergistic effects.	Lycopene	31-39	nuclear receptor subfamily 1 group H member 3	Homo sapiens	91-99
22137263-8	2012	These results demonstrate that lycopene can inhibit DU145 cell proliferation via PPARgamma-LXRalpha-ABCA1 pathway and that lycopene and T0901317 exhibit synergistic effects.	Lycopene	31-39	ATP binding cassette subfamily A member 1	Homo sapiens	100-105
22588536-0	2012	The effect of lycopene treatment on ACE activity in rats with experimental diabetes.	Lycopene	14-22	angiotensin I converting enzyme	Rattus norvegicus	36-39
22512312-0	2012	(13Z)- and (9Z)-lycopene isomers are major intermediates in the oxidative degradation of lycopene by cigarette smoke and Sin-1.	Lycopene	16-24	MAPK associated protein 1	Homo sapiens	121-126
22512312-0	2012	(13Z)- and (9Z)-lycopene isomers are major intermediates in the oxidative degradation of lycopene by cigarette smoke and Sin-1.	Lycopene	89-97	MAPK associated protein 1	Homo sapiens	121-126
22760978-8	2012	Lycopene also significantly inhibited CD69 expression (by up to 12%) as well as IL-2 secretion (by up to 29%).	Lycopene	0-8	interleukin 2	Homo sapiens	80-84
22033431-6	2012	The activities of superoxide dismutase, catalase, and glutathione peroxidase were found to be significantly higher when compared to rats treated with Lyco alone.	Lycopene	150-154	catalase	Rattus norvegicus	40-48
22429818-0	2012	Inhibitory effects of lycopene on HMGB1-mediated pro-inflammatory responses in both cellular and animal models.	Lycopene	22-30	high mobility group box 1	Homo sapiens	34-39
22429818-3	2012	The potential anti-inflammatory roles of lycopene in HMGB1-mediated proinflammatory responses in both primary human umbilical vein endothelial cells (HUVECs) and animal were investigated.	Lycopene	41-49	high mobility group box 1	Homo sapiens	53-58
22554571-10	2012	The superoxide dismutase, catalase and glutathione peroxidase activities as well as the glutathione levels were significantly increased with lycopene administration, while glutathione-S-transferase activity was significantly decreased.	Lycopene	141-149	glutathione peroxidase 1	Oncorhynchus mykiss	39-61
22429818-6	2012	Lycopene inhibited lipopolysaccharide (LPS)-mediated release of HMGB1, expression of HMGB1-mediated tumor necrosis factor (TNF)-secretory phospholipase A2 (sPLA2)-IIA, and HMGB1-mediated pro-inflammatory signaling responses in endothelial cells.	Lycopene	0-8	high mobility group box 1	Homo sapiens	64-69
22429818-6	2012	Lycopene inhibited lipopolysaccharide (LPS)-mediated release of HMGB1, expression of HMGB1-mediated tumor necrosis factor (TNF)-secretory phospholipase A2 (sPLA2)-IIA, and HMGB1-mediated pro-inflammatory signaling responses in endothelial cells.	Lycopene	0-8	high mobility group box 1	Homo sapiens	85-90
22429818-6	2012	Lycopene inhibited lipopolysaccharide (LPS)-mediated release of HMGB1, expression of HMGB1-mediated tumor necrosis factor (TNF)-secretory phospholipase A2 (sPLA2)-IIA, and HMGB1-mediated pro-inflammatory signaling responses in endothelial cells.	Lycopene	0-8	tumor necrosis factor	Homo sapiens	100-121
22429818-6	2012	Lycopene inhibited lipopolysaccharide (LPS)-mediated release of HMGB1, expression of HMGB1-mediated tumor necrosis factor (TNF)-secretory phospholipase A2 (sPLA2)-IIA, and HMGB1-mediated pro-inflammatory signaling responses in endothelial cells.	Lycopene	0-8	tumor necrosis factor	Homo sapiens	123-126
22429818-6	2012	Lycopene inhibited lipopolysaccharide (LPS)-mediated release of HMGB1, expression of HMGB1-mediated tumor necrosis factor (TNF)-secretory phospholipase A2 (sPLA2)-IIA, and HMGB1-mediated pro-inflammatory signaling responses in endothelial cells.	Lycopene	0-8	phospholipase A2 group X	Homo sapiens	156-161
22429818-6	2012	Lycopene inhibited lipopolysaccharide (LPS)-mediated release of HMGB1, expression of HMGB1-mediated tumor necrosis factor (TNF)-secretory phospholipase A2 (sPLA2)-IIA, and HMGB1-mediated pro-inflammatory signaling responses in endothelial cells.	Lycopene	0-8	high mobility group box 1	Homo sapiens	85-90
22429818-8	2012	These findings suggest that lycopene promotes barrier integrity, inhibits monocyte adhesion and migration to HMGB1 activating HUVECs by blocking activation of proinflammatory cytokines and expression of CAMs and HMGB1 receptors, thereby showing its usefulness as a therapy for vascular inflammatory diseases.	Lycopene	28-36	high mobility group box 1	Homo sapiens	109-114
22429818-8	2012	These findings suggest that lycopene promotes barrier integrity, inhibits monocyte adhesion and migration to HMGB1 activating HUVECs by blocking activation of proinflammatory cytokines and expression of CAMs and HMGB1 receptors, thereby showing its usefulness as a therapy for vascular inflammatory diseases.	Lycopene	28-36	high mobility group box 1	Homo sapiens	212-217
22648617-5	2012	The aim of this study was to investigate the potential of orally administered lycopene and all-trans retinoic acid (ATRA) for the induction of the retinoic acid receptor (RAR) in a transgenic retinoic acid response-element (RARE)-reporter mouse system.	Lycopene	78-86	retinoic acid receptor, alpha	Mus musculus	171-174
22531693-7	2012	For rectal cancer we observed the following interactions after adjustment for multiple comparisons: HIF1A and vitamin E, NOS2A (3SNPs) with calcium; MPO with lutein; HIF1A with lycopene; NOS2A with selenium; EPX and NOS2A with aspirin/NSAID use; HIF1A, MPO, and NOS2A (3 SNPs) with cigarette smoking.	Lycopene	177-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	166-171
22531693-7	2012	For rectal cancer we observed the following interactions after adjustment for multiple comparisons: HIF1A and vitamin E, NOS2A (3SNPs) with calcium; MPO with lutein; HIF1A with lycopene; NOS2A with selenium; EPX and NOS2A with aspirin/NSAID use; HIF1A, MPO, and NOS2A (3 SNPs) with cigarette smoking.	Lycopene	177-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	166-171
22707264-0	2012	Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways.	Lycopene	0-8	matrix metallopeptidase 2	Homo sapiens	71-76
22707264-0	2012	Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways.	Lycopene	0-8	plasminogen activator, urokinase	Homo sapiens	77-80
22707264-0	2012	Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways.	Lycopene	0-8	kinase insert domain receptor	Homo sapiens	96-102
22707264-0	2012	Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways.	Lycopene	0-8	AKT serine/threonine kinase 1	Homo sapiens	117-120
22707264-0	2012	Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways.	Lycopene	0-8	mitogen-activated protein kinase 1	Homo sapiens	125-128
22707264-0	2012	Lycopene inhibits angiogenesis both in vitro and in vivo by inhibiting MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways.	Lycopene	0-8	mitogen-activated protein kinase 1	Homo sapiens	129-132
22707264-4	2012	Furthermore, the in vivo matrigel plug assay in mice demonstrated that lycopene implanted s.c. at the highest dose used (400 mug/plug) completely inhibited the formation of vascular endothelial cells induced by vascular endothelial growth factor (VEGF).	Lycopene	71-79	vascular endothelial growth factor A	Mus musculus	211-245
22707264-4	2012	Furthermore, the in vivo matrigel plug assay in mice demonstrated that lycopene implanted s.c. at the highest dose used (400 mug/plug) completely inhibited the formation of vascular endothelial cells induced by vascular endothelial growth factor (VEGF).	Lycopene	71-79	vascular endothelial growth factor A	Mus musculus	247-251
22707264-5	2012	As expected, lycopene inhibited tube formation, invasion, and migration in HUVECs, and such actions were accompanied by reduced activities of matrix metalloproteinase-2, urokinase-type plasminogen activator, and protein expression of Rac1, and by enhancing protein expression of tissue inhibitors of metalloproteinase-2 and plasminogen activator inhibitor-1.	Lycopene	13-21	matrix metallopeptidase 2	Homo sapiens	142-168
22707264-5	2012	As expected, lycopene inhibited tube formation, invasion, and migration in HUVECs, and such actions were accompanied by reduced activities of matrix metalloproteinase-2, urokinase-type plasminogen activator, and protein expression of Rac1, and by enhancing protein expression of tissue inhibitors of metalloproteinase-2 and plasminogen activator inhibitor-1.	Lycopene	13-21	plasminogen activator, urokinase	Homo sapiens	170-206
22707264-5	2012	As expected, lycopene inhibited tube formation, invasion, and migration in HUVECs, and such actions were accompanied by reduced activities of matrix metalloproteinase-2, urokinase-type plasminogen activator, and protein expression of Rac1, and by enhancing protein expression of tissue inhibitors of metalloproteinase-2 and plasminogen activator inhibitor-1.	Lycopene	13-21	Rac family small GTPase 1	Homo sapiens	234-238
22707264-5	2012	As expected, lycopene inhibited tube formation, invasion, and migration in HUVECs, and such actions were accompanied by reduced activities of matrix metalloproteinase-2, urokinase-type plasminogen activator, and protein expression of Rac1, and by enhancing protein expression of tissue inhibitors of metalloproteinase-2 and plasminogen activator inhibitor-1.	Lycopene	13-21	serpin family E member 1	Homo sapiens	300-357
22707264-6	2012	Moreover, lycopene attenuated VEGF receptor-2 (VEGFR2)-mediated phosphorylation of extracellular signal-regulated kinase (ERK), p38, and Akt as well as protein expression of PI3K.	Lycopene	10-18	kinase insert domain receptor	Homo sapiens	30-45
22707264-6	2012	Moreover, lycopene attenuated VEGF receptor-2 (VEGFR2)-mediated phosphorylation of extracellular signal-regulated kinase (ERK), p38, and Akt as well as protein expression of PI3K.	Lycopene	10-18	kinase insert domain receptor	Homo sapiens	47-53
22707264-6	2012	Moreover, lycopene attenuated VEGF receptor-2 (VEGFR2)-mediated phosphorylation of extracellular signal-regulated kinase (ERK), p38, and Akt as well as protein expression of PI3K.	Lycopene	10-18	mitogen-activated protein kinase 1	Homo sapiens	83-120
22707264-6	2012	Moreover, lycopene attenuated VEGF receptor-2 (VEGFR2)-mediated phosphorylation of extracellular signal-regulated kinase (ERK), p38, and Akt as well as protein expression of PI3K.	Lycopene	10-18	mitogen-activated protein kinase 1	Homo sapiens	122-125
22707264-6	2012	Moreover, lycopene attenuated VEGF receptor-2 (VEGFR2)-mediated phosphorylation of extracellular signal-regulated kinase (ERK), p38, and Akt as well as protein expression of PI3K.	Lycopene	10-18	mitogen-activated protein kinase 1	Homo sapiens	128-131
22707264-6	2012	Moreover, lycopene attenuated VEGF receptor-2 (VEGFR2)-mediated phosphorylation of extracellular signal-regulated kinase (ERK), p38, and Akt as well as protein expression of PI3K.	Lycopene	10-18	AKT serine/threonine kinase 1	Homo sapiens	137-140
22707264-8	2012	The anti-angiogenic activity of lycopene may involve inhibition of MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways.	Lycopene	32-40	matrix metallopeptidase 2	Homo sapiens	67-72
22707264-8	2012	The anti-angiogenic activity of lycopene may involve inhibition of MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways.	Lycopene	32-40	plasminogen activator, urokinase	Homo sapiens	73-76
22707264-8	2012	The anti-angiogenic activity of lycopene may involve inhibition of MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways.	Lycopene	32-40	kinase insert domain receptor	Homo sapiens	92-98
22707264-8	2012	The anti-angiogenic activity of lycopene may involve inhibition of MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways.	Lycopene	32-40	AKT serine/threonine kinase 1	Homo sapiens	113-116
22707264-8	2012	The anti-angiogenic activity of lycopene may involve inhibition of MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways.	Lycopene	32-40	mitogen-activated protein kinase 1	Homo sapiens	121-124
22707264-8	2012	The anti-angiogenic activity of lycopene may involve inhibition of MMP-2/uPA system through VEGFR2-mediated PI3K-Akt and ERK/p38 signaling pathways.	Lycopene	32-40	mitogen-activated protein kinase 1	Homo sapiens	125-128
22648617-8	2012	We conclude that lycopene can induce RAR-transcriptional activation in mice and lycopene might be a precursor of still non-identified biologically active metabolites.	Lycopene	17-25	retinoic acid receptor, alpha	Mus musculus	37-40
22648619-0	2012	Lycopene attenuates LPS-induced TNF-alpha secretion in macrophages and inflammatory markers in adipocytes exposed to macrophage-conditioned media.	Lycopene	0-8	tumor necrosis factor	Homo sapiens	32-41
22648619-3	2012	Because lycopene possesses anti-inflammatory properties, we hypothesize that lycopene could reduce the production of TNF-alpha by macrophages and thus interfere in the cross-talk between macrophages and adipocytes.	Lycopene	8-16	tumor necrosis factor	Homo sapiens	117-126
22648619-3	2012	Because lycopene possesses anti-inflammatory properties, we hypothesize that lycopene could reduce the production of TNF-alpha by macrophages and thus interfere in the cross-talk between macrophages and adipocytes.	Lycopene	77-85	tumor necrosis factor	Homo sapiens	117-126
22648619-4	2012	METHODS AND RESULTS: We demonstrated that physiological concentrations of lycopene were able to attenuate the lipopolysaccharide (LPS)-mediated induction of TNF-alpha in RAW 264.7 macrophages, at both the mRNA and protein levels.	Lycopene	74-82	tumor necrosis factor	Homo sapiens	157-166
22648619-6	2012	It appeared that the LPS-activation of both JNK and NF-kappaB signaling pathways was modulated by lycopene.	Lycopene	98-106	mitogen-activated protein kinase 8	Homo sapiens	44-47
22111515-8	2012	One candidate for impact on trans-lycopene and beta-carotene accumulation was functionally charaterized, SlERF6, revealing that it indeed influences carotenoid biosynthesis and additional ripening phenotypes.	Lycopene	28-42	ethylene response factor	Solanum lycopersicum	105-111
22226662-9	2012	Also, changes in plasma total carotenoid and lycopene concentration were inversely correlated with the changes in IL-6 production in LPS-activated PBMCs.	Lycopene	45-53	interleukin 6	Homo sapiens	114-118
22260728-1	2012	Lycopene and its metabolite apo-10"-lycopenoic acid have been shown to induce phase II detoxifying/antioxidant enzymes through activation of the nuclear factor erythroid-derived 2-like 2 (Nrf2)-antioxidant response element (ARE) transcription system.	Lycopene	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	145-186
22259190-9	2012	Because SIRT1 plays a key role in lipid homeostasis, the present study suggests that the lycopene metabolite, ALA, protects against the development of steatosis in ob/ob mice by upregulating SIRT1 gene expression and activity.	Lycopene	89-97	sirtuin 1	Mus musculus	8-13
22259190-9	2012	Because SIRT1 plays a key role in lipid homeostasis, the present study suggests that the lycopene metabolite, ALA, protects against the development of steatosis in ob/ob mice by upregulating SIRT1 gene expression and activity.	Lycopene	89-97	sirtuin 1	Mus musculus	191-196
22260728-6	2012	In addition, the activation time of lycopene on nuclear Nrf2 accumulation is slower than that of apo-8"-lycopenal, suggesting that the chemopreventive effects of lycopene may be partially attributed to its metabolites.	Lycopene	162-170	NFE2 like bZIP transcription factor 2	Homo sapiens	56-60
22260728-1	2012	Lycopene and its metabolite apo-10"-lycopenoic acid have been shown to induce phase II detoxifying/antioxidant enzymes through activation of the nuclear factor erythroid-derived 2-like 2 (Nrf2)-antioxidant response element (ARE) transcription system.	Lycopene	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	188-192
22260728-6	2012	In addition, the activation time of lycopene on nuclear Nrf2 accumulation is slower than that of apo-8"-lycopenal, suggesting that the chemopreventive effects of lycopene may be partially attributed to its metabolites.	Lycopene	36-44	NFE2 like bZIP transcription factor 2	Homo sapiens	56-60
21987235-0	2012	Does lycopene offer human LDL any protection against myeloperoxidase activity?	Lycopene	5-13	myeloperoxidase	Homo sapiens	53-68
22309082-0	2012	Modulation of MMP-9 pathway by lycopene in macrophages and fibroblasts exposed to cigarette smoke.	Lycopene	31-39	matrix metallopeptidase 9	Homo sapiens	14-19
22309082-3	2012	However, at the moment, it is unknown if lycopene may inhibit cigarette smoke-induced MMP-9 expression.	Lycopene	41-49	matrix metallopeptidase 9	Homo sapiens	86-91
22309082-4	2012	Presently, we examined the inhibitory mechanism of lycopene on MMP-9 induction in cultured human macrophages (THP-1 cells), in isolated rat alveolar macrophages (AMs) and in cultured RAT-1 fibroblasts, all cellular sources of MMP-9, exposed to cigarette smoke extract (CSE).	Lycopene	51-59	matrix metallopeptidase 9	Homo sapiens	63-68
22309082-6	2012	A 8 h-lycopene pre-treatment (0.5-2 muM) reduced CSE-mediated MMP-9 induction in a dose- and time-dependent manner.	Lycopene	6-14	matrix metallopeptidase 9	Homo sapiens	62-67
22309082-8	2012	Moreover, lycopene inhibited CSE-induced ERK1/2 and NF-kappaB activation in a dose-dependent manner.	Lycopene	10-18	mitogen-activated protein kinase 3	Homo sapiens	41-47
22309082-9	2012	Lycopene-mediated inhibition of MMP-9 was reversed by mevalonate and associated with a reduced expression of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.	Lycopene	0-8	matrix metallopeptidase 9	Homo sapiens	32-37
22309082-9	2012	Lycopene-mediated inhibition of MMP-9 was reversed by mevalonate and associated with a reduced expression of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.	Lycopene	0-8	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	109-166
22309082-10	2012	Taken together, these results suggest that lycopene may inhibit CSE-mediated MMP-9 induction, primarily by blocking prenylation of Ras in a signaling pathway, in which MEK1/2-ERK1/2 and NF-kappaB are involved.	Lycopene	43-51	matrix metallopeptidase 9	Homo sapiens	77-82
22309082-10	2012	Taken together, these results suggest that lycopene may inhibit CSE-mediated MMP-9 induction, primarily by blocking prenylation of Ras in a signaling pathway, in which MEK1/2-ERK1/2 and NF-kappaB are involved.	Lycopene	43-51	mitogen-activated protein kinase kinase 1	Homo sapiens	168-174
22309082-10	2012	Taken together, these results suggest that lycopene may inhibit CSE-mediated MMP-9 induction, primarily by blocking prenylation of Ras in a signaling pathway, in which MEK1/2-ERK1/2 and NF-kappaB are involved.	Lycopene	43-51	mitogen-activated protein kinase 3	Homo sapiens	175-181
21987235-7	2012	Lycopene does react with the products of myeloperoxidase in solvent, but played no role in protecting against enzyme derived oxidation of human LDL.	Lycopene	0-8	myeloperoxidase	Homo sapiens	41-56
21334870-5	2012	The present study is the first to demonstrate that the anti-proliferative effect of lycopene on LNCaP cells involves the activation of the PPARgamma-LXRalpha-ABCA1 pathway, leading to reduced cellular total cholesterol levels.	Lycopene	84-92	ATP binding cassette subfamily A member 1	Homo sapiens	158-163
22162208-0	2012	beta-Carotene and lycopene affect endothelial response to TNF-alpha reducing nitro-oxidative stress and interaction with monocytes.	Lycopene	18-26	tumor necrosis factor	Homo sapiens	58-67
22428131-4	2012	Lycopene may control redox-sensitive molecular targets, affecting enzyme activities and expressions and modulating the activation of MAPKs and transcription factors, such as NF-kappaB and AP-1, Nrf2.	Lycopene	0-8	MADS-box transcription factor MADS-MC	Solanum lycopersicum	188-192
21334870-0	2012	Lycopene inhibits the proliferation of androgen-dependent human prostate tumor cells through activation of PPARgamma-LXRalpha-ABCA1 pathway.	Lycopene	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	107-116
21334870-0	2012	Lycopene inhibits the proliferation of androgen-dependent human prostate tumor cells through activation of PPARgamma-LXRalpha-ABCA1 pathway.	Lycopene	0-8	nuclear receptor subfamily 1 group H member 3	Homo sapiens	117-125
23226382-9	2012	Moreover, the loss of mitochondrial membrane potential, a decline in cellular ATP levels, a reduction in the amount of cytochrome c translocated to the cytoplasm and caspase-3 activation were observed in lycopene-treated cultures.	Lycopene	204-212	caspase 3	Mus musculus	166-175
21334870-0	2012	Lycopene inhibits the proliferation of androgen-dependent human prostate tumor cells through activation of PPARgamma-LXRalpha-ABCA1 pathway.	Lycopene	0-8	ATP binding cassette subfamily A member 1	Homo sapiens	126-131
21334870-2	2012	This study examined whether the anti-proliferative effect of lycopene on androgen-dependent human prostate cancer (LNCaP) cells involves the up-regulation of the expression of PPARgamma and LXRalpha.	Lycopene	61-69	peroxisome proliferator activated receptor gamma	Homo sapiens	176-185
21334870-2	2012	This study examined whether the anti-proliferative effect of lycopene on androgen-dependent human prostate cancer (LNCaP) cells involves the up-regulation of the expression of PPARgamma and LXRalpha.	Lycopene	61-69	nuclear receptor subfamily 1 group H member 3	Homo sapiens	190-198
21334870-4	2012	LXRalpha knockdown by siRNA against LXRalpha significantly enhanced the proliferation of LNCaP cells, whereas si-LXRalpha knockdown followed by incubation with lycopene (10 muM) restored the proliferation to the control level.	Lycopene	160-168	latexin	Homo sapiens	173-176
21334870-5	2012	The present study is the first to demonstrate that the anti-proliferative effect of lycopene on LNCaP cells involves the activation of the PPARgamma-LXRalpha-ABCA1 pathway, leading to reduced cellular total cholesterol levels.	Lycopene	84-92	peroxisome proliferator activated receptor gamma	Homo sapiens	139-148
21334870-5	2012	The present study is the first to demonstrate that the anti-proliferative effect of lycopene on LNCaP cells involves the activation of the PPARgamma-LXRalpha-ABCA1 pathway, leading to reduced cellular total cholesterol levels.	Lycopene	84-92	nuclear receptor subfamily 1 group H member 3	Homo sapiens	149-157
22211877-4	2012	We found that both apo-8"-lycopenal and lycopene inhibited the invasion and migration of SK-Hep-1 cells, and the effect of apo-8"-lycopenal was stronger than that of lycopene at the same concentration (10 muM).	Lycopene	40-48	latexin	Homo sapiens	205-208
21517710-10	2011	Exogenous administration of lycopene to diabetic rats caused a dose-dependent decrease of serum glucose and ox-LDL levels, an increase of aortic SOD activity, NO levels, and cNOS activity, and a decrease of aortic MDA levels and iNOS activity.	Lycopene	28-36	nitric oxide synthase 3	Rattus norvegicus	174-178
21963687-1	2011	Apo-10"-lycopenoic acid (apo-10-lycac), a metabolite of lycopene, has been shown to possess potent biological activities, notably via the retinoic acid receptors (RAR).	Lycopene	56-64	retinoic acid receptor, alpha	Mus musculus	138-161
21963687-1	2011	Apo-10"-lycopenoic acid (apo-10-lycac), a metabolite of lycopene, has been shown to possess potent biological activities, notably via the retinoic acid receptors (RAR).	Lycopene	56-64	retinoic acid receptor, alpha	Mus musculus	163-166
22044877-3	2011	The present study aims to investigate whether lycopene could provide protective effects against Abeta-induced neurotoxicity in primary cultured rat cortical neurons.	Lycopene	46-54	amyloid beta precursor protein	Rattus norvegicus	96-101
22044877-6	2011	In addition, lycopene inhibited the reactive oxygen species generation and mitochondrial membrane potential depolarization caused by Abeta(25-35).	Lycopene	13-21	amyloid beta precursor protein	Rattus norvegicus	133-138
22044877-7	2011	Lycopene also restored the levels of proapoptotic Bax, antiapoptotic Bcl-2, and inhibited caspase-3 activation.	Lycopene	0-8	BCL2 associated X, apoptosis regulator	Rattus norvegicus	50-53
22044877-7	2011	Lycopene also restored the levels of proapoptotic Bax, antiapoptotic Bcl-2, and inhibited caspase-3 activation.	Lycopene	0-8	BCL2, apoptosis regulator	Rattus norvegicus	69-74
22044877-7	2011	Lycopene also restored the levels of proapoptotic Bax, antiapoptotic Bcl-2, and inhibited caspase-3 activation.	Lycopene	0-8	caspase 3	Rattus norvegicus	90-99
21517710-10	2011	Exogenous administration of lycopene to diabetic rats caused a dose-dependent decrease of serum glucose and ox-LDL levels, an increase of aortic SOD activity, NO levels, and cNOS activity, and a decrease of aortic MDA levels and iNOS activity.	Lycopene	28-36	nitric oxide synthase 2	Rattus norvegicus	229-233
22029620-7	2011	Lycopene levels were correlated with MDA (r = -0.50; p &lt; 0.01), LDL-c (r = -0.38; p = 0.01) levels, the LDL-c/HDL-c index (r = -0.33; p = 0.03) and GPx activity (r = 0.30; p = 0.03).	Lycopene	0-8	component of oligomeric golgi complex 2	Homo sapiens	67-72
21923160-0	2011	Cancer chemopreventive effects of lycopene: suppression of MMP-7 expression and cell invasion in human colon cancer cells.	Lycopene	34-42	matrix metallopeptidase 7	Homo sapiens	59-64
22029620-7	2011	Lycopene levels were correlated with MDA (r = -0.50; p &lt; 0.01), LDL-c (r = -0.38; p = 0.01) levels, the LDL-c/HDL-c index (r = -0.33; p = 0.03) and GPx activity (r = 0.30; p = 0.03).	Lycopene	0-8	component of oligomeric golgi complex 2	Homo sapiens	107-112
21923160-6	2011	Our results demonstrated that lycopene significantly inhibited leptin-mediated cell invasion and MMP-7 expression in human colon cancer HT-29 cells.	Lycopene	30-38	matrix metallopeptidase 7	Homo sapiens	97-102
22029620-8	2011	Regression models showed that lycopene levels were correlated with LDL-c (beta estimated = -31.59; p = 0.04), while gender was correlated with the TC/HDL-c index and triglycerides.	Lycopene	30-38	component of oligomeric golgi complex 2	Homo sapiens	67-72
21923160-9	2011	Lycopene could effectively inhibit the phosphorylation of Akt, glycogen synthase kinase-3beta (GSK-3beta) and ERK 1/2 proteins.	Lycopene	0-8	AKT serine/threonine kinase 1	Homo sapiens	58-61
21744871-5	2011	The results demonstrated that lycopene significantly suppressed the nuclear expression of PCNA and beta-catenin proteins in tumor tissues.	Lycopene	30-38	proliferating cell nuclear antigen	Mus musculus	90-94
21923160-9	2011	Lycopene could effectively inhibit the phosphorylation of Akt, glycogen synthase kinase-3beta (GSK-3beta) and ERK 1/2 proteins.	Lycopene	0-8	glycogen synthase kinase 3 beta	Homo sapiens	63-93
21923160-9	2011	Lycopene could effectively inhibit the phosphorylation of Akt, glycogen synthase kinase-3beta (GSK-3beta) and ERK 1/2 proteins.	Lycopene	0-8	glycogen synthase kinase 3 beta	Homo sapiens	95-104
21923160-9	2011	Lycopene could effectively inhibit the phosphorylation of Akt, glycogen synthase kinase-3beta (GSK-3beta) and ERK 1/2 proteins.	Lycopene	0-8	mitogen-activated protein kinase 3	Homo sapiens	110-117
21923160-10	2011	The molecular mechanisms of lycopene were in part through decreases in nuclear levels of AP-1 and beta-catenin proteins.	Lycopene	28-36	catenin beta 1	Homo sapiens	98-110
21923160-11	2011	These novel findings suggested that lycopene could act as a chemopreventive agent to suppress MMP-7 expression and leptin-mediated cell invasion in human colon cancer HT-29 cells.	Lycopene	36-44	matrix metallopeptidase 7	Homo sapiens	94-99
21262865-5	2011	Results obtained showed that, the combined treatment (epicatechin + lycopene) exert its effects (100%) against toxic effects against lead by lowering the liver enzymes alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and gamma glutamyle transferase (GGT) activities and decrease lipid peroixdation (MDA) and enhances the superoxide dismutase (SOD) activity.	Lycopene	68-76	gamma-glutamyltransferase 1	Rattus norvegicus	257-284
21262865-5	2011	Results obtained showed that, the combined treatment (epicatechin + lycopene) exert its effects (100%) against toxic effects against lead by lowering the liver enzymes alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and gamma glutamyle transferase (GGT) activities and decrease lipid peroixdation (MDA) and enhances the superoxide dismutase (SOD) activity.	Lycopene	68-76	gamma-glutamyltransferase 1	Rattus norvegicus	286-289
21208793-3	2011	Incubation of THP-1 cells with lycopene (0.5-2 muM) dose-dependently reduced intracellular total cholesterol.	Lycopene	31-39	latexin	Homo sapiens	47-50
21208793-5	2011	In addition, lycopene enhanced RhoA levels in the cytosolic fraction, activating peroxisome proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha expressions.	Lycopene	13-21	ras homolog family member A	Homo sapiens	31-35
21208793-5	2011	In addition, lycopene enhanced RhoA levels in the cytosolic fraction, activating peroxisome proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha expressions.	Lycopene	13-21	peroxisome proliferator activated receptor gamma	Homo sapiens	81-129
21208793-5	2011	In addition, lycopene enhanced RhoA levels in the cytosolic fraction, activating peroxisome proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha expressions.	Lycopene	13-21	peroxisome proliferator activated receptor gamma	Homo sapiens	131-140
21208793-6	2011	Concomitant addition of lycopene and the PPARgamma inhibitor GW9662 or lycopene and mevalonate blocked the carotenoid-induced increase in ABCA1 and cav-1 expressions.	Lycopene	24-32	ATP binding cassette subfamily A member 1	Homo sapiens	138-143
21208793-6	2011	Concomitant addition of lycopene and the PPARgamma inhibitor GW9662 or lycopene and mevalonate blocked the carotenoid-induced increase in ABCA1 and cav-1 expressions.	Lycopene	24-32	caveolin 1	Homo sapiens	148-153
21208793-6	2011	Concomitant addition of lycopene and the PPARgamma inhibitor GW9662 or lycopene and mevalonate blocked the carotenoid-induced increase in ABCA1 and cav-1 expressions.	Lycopene	71-79	ATP binding cassette subfamily A member 1	Homo sapiens	138-143
21208793-6	2011	Concomitant addition of lycopene and the PPARgamma inhibitor GW9662 or lycopene and mevalonate blocked the carotenoid-induced increase in ABCA1 and cav-1 expressions.	Lycopene	71-79	caveolin 1	Homo sapiens	148-153
21208793-7	2011	These results imply a potential role of lycopene in attenuating foam cell formation and, therefore, in preventing atherosclerosis by a cascade mechanism involving inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, RhoA inactivation and subsequent increase in PPARgamma and liver X receptor alpha activities and enhancement of ABCA1 and cav-1 expressions.	Lycopene	40-48	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	177-224
21208793-7	2011	These results imply a potential role of lycopene in attenuating foam cell formation and, therefore, in preventing atherosclerosis by a cascade mechanism involving inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, RhoA inactivation and subsequent increase in PPARgamma and liver X receptor alpha activities and enhancement of ABCA1 and cav-1 expressions.	Lycopene	40-48	ras homolog family member A	Homo sapiens	226-230
21208793-7	2011	These results imply a potential role of lycopene in attenuating foam cell formation and, therefore, in preventing atherosclerosis by a cascade mechanism involving inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, RhoA inactivation and subsequent increase in PPARgamma and liver X receptor alpha activities and enhancement of ABCA1 and cav-1 expressions.	Lycopene	40-48	peroxisome proliferator activated receptor gamma	Homo sapiens	271-280
21208793-7	2011	These results imply a potential role of lycopene in attenuating foam cell formation and, therefore, in preventing atherosclerosis by a cascade mechanism involving inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, RhoA inactivation and subsequent increase in PPARgamma and liver X receptor alpha activities and enhancement of ABCA1 and cav-1 expressions.	Lycopene	40-48	ATP binding cassette subfamily A member 1	Homo sapiens	338-343
21208793-7	2011	These results imply a potential role of lycopene in attenuating foam cell formation and, therefore, in preventing atherosclerosis by a cascade mechanism involving inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, RhoA inactivation and subsequent increase in PPARgamma and liver X receptor alpha activities and enhancement of ABCA1 and cav-1 expressions.	Lycopene	40-48	caveolin 1	Homo sapiens	348-353
21672580-3	2011	This review focuses on the role of carotenoids like retinoic acid (RA), all trans retinoic acid (ATRA), lycopene and beta-carotene in prevention of AD symptoms primarily through inhibition of amyloid beta (Abeta) formation, deposition and fibril formation either by reducing the levels of p35 or inhibiting corresponding enzymes.	Lycopene	104-112	amyloid beta precursor protein	Homo sapiens	192-204
21672580-3	2011	This review focuses on the role of carotenoids like retinoic acid (RA), all trans retinoic acid (ATRA), lycopene and beta-carotene in prevention of AD symptoms primarily through inhibition of amyloid beta (Abeta) formation, deposition and fibril formation either by reducing the levels of p35 or inhibiting corresponding enzymes.	Lycopene	104-112	amyloid beta precursor protein	Homo sapiens	206-211
21744871-5	2011	The results demonstrated that lycopene significantly suppressed the nuclear expression of PCNA and beta-catenin proteins in tumor tissues.	Lycopene	30-38	catenin (cadherin associated protein), beta 1	Mus musculus	99-111
21744871-6	2011	Consumption of lycopene could also augment the E-cadherin adherent molecule and nuclear levels of cell cycle inhibitor p21(CIP1/WAF1) protein.	Lycopene	15-23	cadherin 1	Mus musculus	47-57
21744871-6	2011	Consumption of lycopene could also augment the E-cadherin adherent molecule and nuclear levels of cell cycle inhibitor p21(CIP1/WAF1) protein.	Lycopene	15-23	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	119-122
21744871-6	2011	Consumption of lycopene could also augment the E-cadherin adherent molecule and nuclear levels of cell cycle inhibitor p21(CIP1/WAF1) protein.	Lycopene	15-23	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	123-127
21744871-6	2011	Consumption of lycopene could also augment the E-cadherin adherent molecule and nuclear levels of cell cycle inhibitor p21(CIP1/WAF1) protein.	Lycopene	15-23	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	128-132
21744871-7	2011	The chemopreventive effects of lycopene were associated with suppression of COX-2, PGE(2), and phosphorylated ERK1/2 proteins.	Lycopene	31-39	cytochrome c oxidase II, mitochondrial	Mus musculus	76-81
21744871-7	2011	The chemopreventive effects of lycopene were associated with suppression of COX-2, PGE(2), and phosphorylated ERK1/2 proteins.	Lycopene	31-39	mitogen-activated protein kinase 3	Mus musculus	110-116
21744871-8	2011	Furthermore, the inhibitory effects of lycopene were inversely correlated with the plasma levels of matrix metalloproteinase 9 (MMP-9) in tumor-bearing mice.	Lycopene	39-47	matrix metallopeptidase 9	Mus musculus	100-126
21744871-8	2011	Furthermore, the inhibitory effects of lycopene were inversely correlated with the plasma levels of matrix metalloproteinase 9 (MMP-9) in tumor-bearing mice.	Lycopene	39-47	matrix metallopeptidase 9	Mus musculus	128-133
21487789-5	2011	Further studies revealed that lycopene suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and activation of nuclear factor-kappaB (NF-kappaB), CD14 and Toll-like receptor-4 (TLR4).	Lycopene	30-38	tumor necrosis factor	Homo sapiens	68-95
21377758-9	2011	The results indicated that the yellow phenotype observed in Pds-silenced fruit was mainly due to the lack of the red-colored lycopene and therefore to a more pronounced contribution of the yellow-orange carotenoids (lutein, violaxanthin, and zeaxanthin) to the final color of the fruits.	Lycopene	125-133	15-cis-phytoene desaturase, chloroplastic/chromoplastic	Solanum lycopersicum	60-63
21487789-5	2011	Further studies revealed that lycopene suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and activation of nuclear factor-kappaB (NF-kappaB), CD14 and Toll-like receptor-4 (TLR4).	Lycopene	30-38	tumor necrosis factor	Homo sapiens	97-106
21487789-5	2011	Further studies revealed that lycopene suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and activation of nuclear factor-kappaB (NF-kappaB), CD14 and Toll-like receptor-4 (TLR4).	Lycopene	30-38	nuclear factor kappa B subunit 1	Homo sapiens	126-147
21487789-5	2011	Further studies revealed that lycopene suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and activation of nuclear factor-kappaB (NF-kappaB), CD14 and Toll-like receptor-4 (TLR4).	Lycopene	30-38	nuclear factor kappa B subunit 1	Homo sapiens	149-158
21487789-5	2011	Further studies revealed that lycopene suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and activation of nuclear factor-kappaB (NF-kappaB), CD14 and Toll-like receptor-4 (TLR4).	Lycopene	30-38	CD14 molecule	Homo sapiens	161-165
21487789-5	2011	Further studies revealed that lycopene suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and activation of nuclear factor-kappaB (NF-kappaB), CD14 and Toll-like receptor-4 (TLR4).	Lycopene	30-38	toll like receptor 4	Homo sapiens	170-190
21487789-5	2011	Further studies revealed that lycopene suppressed the production of tumor necrosis factor-alpha (TNF-alpha) and activation of nuclear factor-kappaB (NF-kappaB), CD14 and Toll-like receptor-4 (TLR4).	Lycopene	30-38	toll like receptor 4	Homo sapiens	192-196
21487789-6	2011	CONCLUSION: These findings suggest that lycopene has barrier integrity activity, and inhibitory activity on cell adhesion and migration to endothelial cells by blocking the activation of NF-kappaB, CD14 and TLR4 expression and production of TNF-alpha, thereby endorsing its usefulness as therapy for vascular inflammatory diseases.	Lycopene	40-48	nuclear factor kappa B subunit 1	Homo sapiens	187-196
21487789-6	2011	CONCLUSION: These findings suggest that lycopene has barrier integrity activity, and inhibitory activity on cell adhesion and migration to endothelial cells by blocking the activation of NF-kappaB, CD14 and TLR4 expression and production of TNF-alpha, thereby endorsing its usefulness as therapy for vascular inflammatory diseases.	Lycopene	40-48	CD14 molecule	Homo sapiens	198-202
21487789-6	2011	CONCLUSION: These findings suggest that lycopene has barrier integrity activity, and inhibitory activity on cell adhesion and migration to endothelial cells by blocking the activation of NF-kappaB, CD14 and TLR4 expression and production of TNF-alpha, thereby endorsing its usefulness as therapy for vascular inflammatory diseases.	Lycopene	40-48	toll like receptor 4	Homo sapiens	207-211
21487789-6	2011	CONCLUSION: These findings suggest that lycopene has barrier integrity activity, and inhibitory activity on cell adhesion and migration to endothelial cells by blocking the activation of NF-kappaB, CD14 and TLR4 expression and production of TNF-alpha, thereby endorsing its usefulness as therapy for vascular inflammatory diseases.	Lycopene	40-48	tumor necrosis factor	Homo sapiens	241-250
20952175-3	2011	In agreement with this hypothesis, we observed a decrease of inflammatory markers such as IL-6, MCP-1 and IL-1beta at both the mRNA and protein level when explants of epididymal adipose tissue from mice fed with a high-fat diet were incubated with lycopene ex vivo.	Lycopene	248-256	interleukin 6	Mus musculus	90-94
20952175-6	2011	In both preadipocytes and differentiated 3T3-L1 adipocytes, lycopene preincubation for 24 h decreased the TNFalpha-mediated induction of IL-6 and MCP-1.	Lycopene	60-68	tumor necrosis factor	Homo sapiens	106-114
20952175-6	2011	In both preadipocytes and differentiated 3T3-L1 adipocytes, lycopene preincubation for 24 h decreased the TNFalpha-mediated induction of IL-6 and MCP-1.	Lycopene	60-68	interleukin 6	Homo sapiens	137-141
20952175-6	2011	In both preadipocytes and differentiated 3T3-L1 adipocytes, lycopene preincubation for 24 h decreased the TNFalpha-mediated induction of IL-6 and MCP-1.	Lycopene	60-68	C-C motif chemokine ligand 2	Homo sapiens	146-151
20952175-9	2011	In transient transfections, a decrease of the luciferase gene reporter under control of NF-kappaB responsive element was observed for cells incubated in the presence of lycopene and TNFalpha compared to TNFalpha alone.	Lycopene	169-177	nuclear factor kappa B subunit 1	Homo sapiens	88-97
20952175-9	2011	In transient transfections, a decrease of the luciferase gene reporter under control of NF-kappaB responsive element was observed for cells incubated in the presence of lycopene and TNFalpha compared to TNFalpha alone.	Lycopene	169-177	tumor necrosis factor	Homo sapiens	203-211
20952175-10	2011	The involvement of the NF-kappaB pathway was confirmed by the modulation of IKKalpha/beta phosphorylation by lycopene.	Lycopene	109-117	nuclear factor kappa B subunit 1	Homo sapiens	23-32
20952175-10	2011	The involvement of the NF-kappaB pathway was confirmed by the modulation of IKKalpha/beta phosphorylation by lycopene.	Lycopene	109-117	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	76-84
21216390-10	2011	A decreased percentage of PCNA-positive nuclei was associated with lycopene treatment.	Lycopene	67-75	proliferating cell nuclear antigen	Rattus norvegicus	26-30
21216390-12	2011	Increased E-cadherin and beta-catenin immunoexpression was recorded in the lycopene treated group in comparison to the carcinogen group.	Lycopene	75-83	cadherin 1	Rattus norvegicus	10-20
21216390-12	2011	Increased E-cadherin and beta-catenin immunoexpression was recorded in the lycopene treated group in comparison to the carcinogen group.	Lycopene	75-83	catenin beta 1	Rattus norvegicus	25-37
21986126-7	2011	In lycopene + radiotherapy groups, malondialdehyde levels decreased significantly and GSH levels, GSH-Px and SOD activity increased significantly compared with radiotherapy groups.	Lycopene	3-11	glutathione peroxidase 1	Rattus norvegicus	98-104
21598989-9	2011	However, the decrease in Skp2 levels in cells treated with 5gg or lycopene did not translate to p27 upregulation.	Lycopene	66-74	S-phase kinase associated protein 2	Homo sapiens	25-29
21598989-12	2011	Furthermore, our results reveal that FoxO1 protein was increased after 5gg, quercetin, curcumin and lycopene treatment.	Lycopene	100-108	forkhead box O1	Homo sapiens	37-42
21421019-0	2011	Lycopene inhibits DNA damage and reduces hMTH1 mRNA expression in the liver of Mongolian gerbils treated with ferric nitrilotriacetate.	Lycopene	0-8	nudix hydrolase 1	Homo sapiens	41-46
21421019-6	2011	Supplemental lycopene completely inhibited Comet formation (P&lt;0.001) and significantly suppressed 8-oxo-dG levels and hMTH1 expression in a dose-dependent manner.	Lycopene	13-21	nudix hydrolase 1	Homo sapiens	121-126
21484151-0	2011	Lycopene inhibits IL-6 expression in cerulein-stimulated pancreatic acinar cells.	Lycopene	0-8	interleukin 6	Homo sapiens	18-22
21484151-10	2011	Lycopene inhibited the cerulein-induced increase in intracellular ROS, NF-kappaB activation, and IL-6 expression in pancreatic acinar cells in a dose-dependent manner.	Lycopene	0-8	nuclear factor kappa B subunit 1	Homo sapiens	71-80
21484151-10	2011	Lycopene inhibited the cerulein-induced increase in intracellular ROS, NF-kappaB activation, and IL-6 expression in pancreatic acinar cells in a dose-dependent manner.	Lycopene	0-8	interleukin 6	Homo sapiens	97-101
21484151-11	2011	In conclusion, lycopene may be beneficial in the prevention and/or treatment of acute pancreatitis by inhibiting the activation of NF-kappaB and the expression of inflammatory cytokines through reduction in intracellular levels of ROS in pancreatic acinar cells.	Lycopene	15-23	nuclear factor kappa B subunit 1	Homo sapiens	131-140
20580031-8	2011	Brachial-ankle pulse wave velocity inversely correlated with serum lycopene after adjustment for the above confounders, blood pressure, insulin resistance, and oxidative stress (r = -0.136, P &lt; .05).	Lycopene	67-75	insulin	Homo sapiens	136-143
21103921-3	2011	We hypothesized that lycopene or fish oil supplements would down-regulate insulin-like growth factor-1 (IGF-1) and cyclooxygenase 2 (COX-2) gene expression, respectively, reflecting putative proliferation (IGF-1) and inflammatory (COX-2) pathways relevant to carcinogenesis.	Lycopene	21-29	insulin like growth factor 1	Homo sapiens	104-109
21103921-3	2011	We hypothesized that lycopene or fish oil supplements would down-regulate insulin-like growth factor-1 (IGF-1) and cyclooxygenase 2 (COX-2) gene expression, respectively, reflecting putative proliferation (IGF-1) and inflammatory (COX-2) pathways relevant to carcinogenesis.	Lycopene	21-29	insulin like growth factor 1	Homo sapiens	206-211
21598989-0	2011	1,2,3,4,6-penta-O-galloyl-beta-D-glucose, quercetin, curcumin and lycopene induce cell-cycle arrest in MDA-MB-231 and BT474 cells through downregulation of Skp2 protein.	Lycopene	66-74	S-phase kinase associated protein 2	Homo sapiens	156-160
21335507-7	2011	In the placebo arm, a 10 mug/dL increase in lycopene was associated with a 7% (95% CI: 14-0) reduced risk of cancer diagnosed following an elevated PSA or abnormal DRE, which are cancers that best match those detected in screened populations.	Lycopene	44-52	kallikrein related peptidase 3	Homo sapiens	148-151
21462328-5	2011	High-dosage lycopene and beta-carotene significantly decreased the expression of proliferating cell nuclear antigen in tumor tissues and increased the levels of insulin-like growth factor-binding protein-3 in plasma.	Lycopene	12-20	insulin-like growth factor binding protein 3	Mus musculus	161-205
21462328-6	2011	In addition, high-dosage lycopene supplementation significantly decreased the vascular endothelial growth factor (VEGF) levels in plasma.	Lycopene	25-33	vascular endothelial growth factor A	Mus musculus	78-112
21462328-6	2011	In addition, high-dosage lycopene supplementation significantly decreased the vascular endothelial growth factor (VEGF) levels in plasma.	Lycopene	25-33	vascular endothelial growth factor A	Mus musculus	114-118
21462328-8	2011	CONCLUSION: Lycopene and beta-carotene supplementation suppressed the growth of prostate tumor cells, and the effects are likely associated with reduction of proliferation (attenuation of proliferating cell nuclear antigen expression) and with interference of the insulin-like growth factor 1 signaling (increased plasma insulin-like growth factor-binding protein-3 levels).	Lycopene	12-20	insulin-like growth factor binding protein 3	Mus musculus	321-365
21462328-9	2011	Furthermore, the inhibition of VEGF by lycopene suggests that the antitumor mechanisms of lycopene also involve anti-angiogenesis.	Lycopene	39-47	vascular endothelial growth factor A	Mus musculus	31-35
21462328-9	2011	Furthermore, the inhibition of VEGF by lycopene suggests that the antitumor mechanisms of lycopene also involve anti-angiogenesis.	Lycopene	90-98	vascular endothelial growth factor A	Mus musculus	31-35
20573495-0	2011	Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-kappaB nuclear binding and increase in PPARgamma expression.	Lycopene	0-8	nuclear factor kappa B subunit 1	Homo sapiens	110-119
20573495-0	2011	Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-kappaB nuclear binding and increase in PPARgamma expression.	Lycopene	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	152-161
21403837-0	2011	Lycopene enhances docetaxel"s effect in castration-resistant prostate cancer associated with insulin-like growth factor I receptor levels.	Lycopene	0-8	insulin like growth factor 1 receptor	Homo sapiens	93-130
21403837-4	2011	The growth-inhibitory effect of lycopene on PCa cell lines was positively associated with insulin-like growth factor I receptor (IGF-IR) levels.	Lycopene	32-40	insulin like growth factor 1 receptor	Homo sapiens	90-127
21403837-4	2011	The growth-inhibitory effect of lycopene on PCa cell lines was positively associated with insulin-like growth factor I receptor (IGF-IR) levels.	Lycopene	32-40	insulin like growth factor 1 receptor	Homo sapiens	129-135
21403837-5	2011	In addition, lycopene treatment enhanced the growth-inhibitory effect of docetaxel more effectively on DU145 cells with IGF-IR high expression than on those PCa cell lines with IGF-IR low expression.	Lycopene	13-21	insulin like growth factor 1 receptor	Homo sapiens	120-126
21403837-5	2011	In addition, lycopene treatment enhanced the growth-inhibitory effect of docetaxel more effectively on DU145 cells with IGF-IR high expression than on those PCa cell lines with IGF-IR low expression.	Lycopene	13-21	insulin like growth factor 1 receptor	Homo sapiens	177-183
21403837-7	2011	Lycopene inhibited IGF-IR activation through inhibiting IGF-I stimulation and by increasing the expression and secretion of IGF-BP3.	Lycopene	0-8	insulin like growth factor 1 receptor	Homo sapiens	19-25
21403837-7	2011	Lycopene inhibited IGF-IR activation through inhibiting IGF-I stimulation and by increasing the expression and secretion of IGF-BP3.	Lycopene	0-8	insulin like growth factor 1	Homo sapiens	19-24
21403837-7	2011	Lycopene inhibited IGF-IR activation through inhibiting IGF-I stimulation and by increasing the expression and secretion of IGF-BP3.	Lycopene	0-8	insulin like growth factor binding protein 3	Homo sapiens	124-131
21391123-0	2011	A tomato lycopene complex protects the kidney from cisplatin-induced injury via affecting oxidative stress as well as Bax, Bcl-2, and HSPs expression.	Lycopene	9-17	BCL2 associated X, apoptosis regulator	Rattus norvegicus	118-121
20392623-0	2011	Dietary lycopene supplementation suppresses Th2 responses and lung eosinophilia in a mouse model of allergic asthma.	Lycopene	8-16	heart and neural crest derivatives expressed 2	Mus musculus	44-47
20392623-5	2011	BALB/c mice receiving lycopene supplement or control were intraperitoneally sensitised and intranasally challenged with ovalbumin (OVA) to induce AAD.	Lycopene	22-30	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	120-129
21391123-10	2011	Renal Bax protein expression was significantly higher in the cisplatin-treated rats than in the control rats, and tomato lycopene complex treatment significantly reduced Bax expression (P &lt; 0.001).	Lycopene	121-129	BCL2 associated X, apoptosis regulator	Rattus norvegicus	170-173
21391123-12	2011	The expression of renal HSP60 and HSP70 was significantly lower in tomato lycopene complex + cisplatin-treated rats than in rats treated with cisplatin alone (P &lt; 0.001).	Lycopene	74-82	heat shock protein 70	Solanum lycopersicum	34-39
20400267-9	2010	RESEARCH METHODS AND PROCEDURES: The inhibitory action of lycopene on CYP1 enzymes was assessed in recombinant protein and cell culture using ethoxyresorufin-O-deethylase assay.	Lycopene	58-66	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	70-74
21625550-0	2011	Lycopene inhibits NF-kB-mediated IL-8 expression and changes redox and PPARgamma signalling in cigarette smoke-stimulated macrophages.	Lycopene	0-8	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	18-23
21625550-0	2011	Lycopene inhibits NF-kB-mediated IL-8 expression and changes redox and PPARgamma signalling in cigarette smoke-stimulated macrophages.	Lycopene	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
21625550-0	2011	Lycopene inhibits NF-kB-mediated IL-8 expression and changes redox and PPARgamma signalling in cigarette smoke-stimulated macrophages.	Lycopene	0-8	peroxisome proliferator activated receptor gamma	Homo sapiens	71-80
21625550-3	2011	The aim of this study was to investigate the role of lycopene on the production of the pro-inflammatory cytokine IL-8 induced by cigarette smoke and the possible mechanisms implicated.	Lycopene	53-61	C-X-C motif chemokine ligand 8	Homo sapiens	113-117
21625550-6	2011	Lycopene pre-treatment resulted in a significant inhibition of CSE-induced IL-8 expression at both mRNA and protein levels.	Lycopene	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
21625550-8	2011	Lycopene suppressed CSE-induced NF-kB DNA binding, NF-kB/p65 nuclear translocation and phosphorylation of IKKalpha and IkBalpha.	Lycopene	0-8	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	32-37
21625550-8	2011	Lycopene suppressed CSE-induced NF-kB DNA binding, NF-kB/p65 nuclear translocation and phosphorylation of IKKalpha and IkBalpha.	Lycopene	0-8	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	51-56
21625550-8	2011	Lycopene suppressed CSE-induced NF-kB DNA binding, NF-kB/p65 nuclear translocation and phosphorylation of IKKalpha and IkBalpha.	Lycopene	0-8	RELA proto-oncogene, NF-kB subunit	Homo sapiens	57-60
21625550-8	2011	Lycopene suppressed CSE-induced NF-kB DNA binding, NF-kB/p65 nuclear translocation and phosphorylation of IKKalpha and IkBalpha.	Lycopene	0-8	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	106-127
21625550-10	2011	Lycopene further inhibited CSE-induced phosphorylation of the redox-sensitive ERK1/2, JNK and p38 MAPKs.	Lycopene	0-8	mitogen-activated protein kinase 3	Homo sapiens	78-84
21625550-10	2011	Lycopene further inhibited CSE-induced phosphorylation of the redox-sensitive ERK1/2, JNK and p38 MAPKs.	Lycopene	0-8	mitogen-activated protein kinase 8	Homo sapiens	86-89
21625550-10	2011	Lycopene further inhibited CSE-induced phosphorylation of the redox-sensitive ERK1/2, JNK and p38 MAPKs.	Lycopene	0-8	mitogen-activated protein kinase 1	Homo sapiens	94-97
21625550-13	2011	Taken together, our data indicate that lycopene prevented CSE-induced IL-8 production through a mechanism involving an inactivation of NF-kB.	Lycopene	39-47	C-X-C motif chemokine ligand 8	Homo sapiens	70-74
21625550-13	2011	Taken together, our data indicate that lycopene prevented CSE-induced IL-8 production through a mechanism involving an inactivation of NF-kB.	Lycopene	39-47	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	135-140
21625550-15	2011	The ability of lycopene in inhibiting IL-8 production, NF-kB/p65 nuclear translocation, and redox signalling and in increasing PPARgamma expression was also found in isolated rat alveolar macrophages exposed to CSE.	Lycopene	15-23	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
21625550-15	2011	The ability of lycopene in inhibiting IL-8 production, NF-kB/p65 nuclear translocation, and redox signalling and in increasing PPARgamma expression was also found in isolated rat alveolar macrophages exposed to CSE.	Lycopene	15-23	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	55-60
21625550-15	2011	The ability of lycopene in inhibiting IL-8 production, NF-kB/p65 nuclear translocation, and redox signalling and in increasing PPARgamma expression was also found in isolated rat alveolar macrophages exposed to CSE.	Lycopene	15-23	synaptotagmin 1	Rattus norvegicus	61-64
21625550-15	2011	The ability of lycopene in inhibiting IL-8 production, NF-kB/p65 nuclear translocation, and redox signalling and in increasing PPARgamma expression was also found in isolated rat alveolar macrophages exposed to CSE.	Lycopene	15-23	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	127-136
20400267-12	2010	RESULTS: Lycopene inhibited recombinant CYP1A1 and CYP1B1 with estimated K(i)s in the micromolar range.	Lycopene	9-17	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	40-46
20400267-12	2010	RESULTS: Lycopene inhibited recombinant CYP1A1 and CYP1B1 with estimated K(i)s in the micromolar range.	Lycopene	9-17	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	51-57
20953409-4	2010	Inflammation, steatosis, alpha-smooth muscle actin (alpha-SMA), and cytochrome P450 2E1 (CYP 2E1) expression increased significantly in the rats fed HFD and decreased in the rats administered by lycopene.	Lycopene	195-203	actin gamma 2, smooth muscle	Rattus norvegicus	25-50
20953409-4	2010	Inflammation, steatosis, alpha-smooth muscle actin (alpha-SMA), and cytochrome P450 2E1 (CYP 2E1) expression increased significantly in the rats fed HFD and decreased in the rats administered by lycopene.	Lycopene	195-203	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	68-87
20953409-4	2010	Inflammation, steatosis, alpha-smooth muscle actin (alpha-SMA), and cytochrome P450 2E1 (CYP 2E1) expression increased significantly in the rats fed HFD and decreased in the rats administered by lycopene.	Lycopene	195-203	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	89-96
20953409-6	2010	Supplementation with lycopene lowered serum MDA and tumor necrosis factor (TNF-alpha) levels and elevated liver GSH level (P &lt; .001).	Lycopene	21-29	tumor necrosis factor-like	Rattus norvegicus	52-73
20953409-6	2010	Supplementation with lycopene lowered serum MDA and tumor necrosis factor (TNF-alpha) levels and elevated liver GSH level (P &lt; .001).	Lycopene	21-29	tumor necrosis factor	Rattus norvegicus	75-84
20687227-0	2010	Chemoprevention of prostate cancer with lycopene in the TRAMP model.	Lycopene	40-48	tumor necrosis factor receptor superfamily, member 25	Mus musculus	56-61
20603177-0	2010	Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene.	Lycopene	111-119	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
20603177-0	2010	Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene.	Lycopene	111-119	heme oxygenase 1	Rattus norvegicus	5-9
20603177-3	2010	This study reports that lycopene mitigates the nephrotoxic effect of cisplatin in rat through Nrf2-mediated induction of heme oxygenase-1 (HO-1).	Lycopene	24-32	NFE2 like bZIP transcription factor 2	Rattus norvegicus	94-98
20603177-3	2010	This study reports that lycopene mitigates the nephrotoxic effect of cisplatin in rat through Nrf2-mediated induction of heme oxygenase-1 (HO-1).	Lycopene	24-32	heme oxygenase 1	Rattus norvegicus	121-137
20603177-3	2010	This study reports that lycopene mitigates the nephrotoxic effect of cisplatin in rat through Nrf2-mediated induction of heme oxygenase-1 (HO-1).	Lycopene	24-32	heme oxygenase 1	Rattus norvegicus	139-143
20603177-6	2010	Western blot analysis of renal Nrf2, HO-1 and NF-kappaB p65 showed that cisplatin-induced decrease in the levels of Nrf-2 and HO-1 was counteracted by lycopene.	Lycopene	151-159	NFE2 like bZIP transcription factor 2	Rattus norvegicus	31-35
20603177-6	2010	Western blot analysis of renal Nrf2, HO-1 and NF-kappaB p65 showed that cisplatin-induced decrease in the levels of Nrf-2 and HO-1 was counteracted by lycopene.	Lycopene	151-159	heme oxygenase 1	Rattus norvegicus	37-41
20603177-6	2010	Western blot analysis of renal Nrf2, HO-1 and NF-kappaB p65 showed that cisplatin-induced decrease in the levels of Nrf-2 and HO-1 was counteracted by lycopene.	Lycopene	151-159	NFE2 like bZIP transcription factor 2	Rattus norvegicus	116-121
20603177-6	2010	Western blot analysis of renal Nrf2, HO-1 and NF-kappaB p65 showed that cisplatin-induced decrease in the levels of Nrf-2 and HO-1 was counteracted by lycopene.	Lycopene	151-159	heme oxygenase 1	Rattus norvegicus	126-130
20603177-9	2010	The study suggests that Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene, and reduces inflammation by inhibiting NF-kappaB.	Lycopene	135-143	NFE2 like bZIP transcription factor 2	Rattus norvegicus	24-28
20603177-9	2010	The study suggests that Nrf2/HO-1 signaling pathway may be the prime target for chemoprevention of cisplatin-induced nephrotoxicity by lycopene, and reduces inflammation by inhibiting NF-kappaB.	Lycopene	135-143	heme oxygenase 1	Rattus norvegicus	29-33
20699249-4	2010	Incubation of the Ras-activated prostatic carcinoma LNCaP cells with a 24 h lycopene treatment (2.5-10 muM) dose dependently reduced intracellular total cholesterol by decreasing 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase expression and by inactivating Ras, as evidenced by its translocation from cell membranes to cytosol.	Lycopene	76-84	latexin	Homo sapiens	103-106
20699249-4	2010	Incubation of the Ras-activated prostatic carcinoma LNCaP cells with a 24 h lycopene treatment (2.5-10 muM) dose dependently reduced intracellular total cholesterol by decreasing 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase expression and by inactivating Ras, as evidenced by its translocation from cell membranes to cytosol.	Lycopene	76-84	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	179-236
20731353-4	2010	When grown with [U]-13C-glucose and treated with CPTA, hp-1 suspensions yielded highly enriched 13C-lycopene with 45% of lycopene in the M+40 form and 88% in the M+35 to M+40 isotopomer range.	Lycopene	100-108	DNA damage-binding protein 1	Solanum lycopersicum	55-59
20676966-4	2010	The results showed that lycopene and simvastatin applied together reduced TNFalpha and IFNgamma secretion, and abolished the increased production of the proinflammatory cytokine IL-1gamma caused by incubation with simvastatin only, an observation suggesting that simultaneous administration of both substances may reduce inflammatory responses.	Lycopene	24-32	tumor necrosis factor	Homo sapiens	74-82
20860968-0	2010	Effects of lycopene, indole-3-carbinol, and luteolin on nitric oxide production and iNOS expression are organ-specific in rats.	Lycopene	11-19	nitric oxide synthase 2	Rattus norvegicus	84-88
20860968-2	2010	The aim of this study was to see how natural compounds luteolin, indole-3-carbinol, and lycopene modify NO production in rat tissues and change the expression of the iNOS gene and protein.	Lycopene	88-96	nitric oxide synthase 2	Rattus norvegicus	166-170
20860968-6	2010	Lycopene increased the iNOS gene transcription rate in the brain cortex of LPS-treated animals.	Lycopene	0-8	nitric oxide synthase 2	Rattus norvegicus	23-27
20431935-6	2010	The protective effect of the mutant allele of the COX-2 polymorphism was more pronounced among subjects with high plasma levels of beta-cryptoxanthin, lycopene, beta-carotene, or selenium (&gt;or=median) [e.g., OR (95% CI): 0.37 (0.15, 0.86) (AG/GG vs. AA) for beta-cryptoxanthin].	Lycopene	151-159	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55
20676966-4	2010	The results showed that lycopene and simvastatin applied together reduced TNFalpha and IFNgamma secretion, and abolished the increased production of the proinflammatory cytokine IL-1gamma caused by incubation with simvastatin only, an observation suggesting that simultaneous administration of both substances may reduce inflammatory responses.	Lycopene	24-32	interferon gamma	Homo sapiens	87-95
20676966-4	2010	The results showed that lycopene and simvastatin applied together reduced TNFalpha and IFNgamma secretion, and abolished the increased production of the proinflammatory cytokine IL-1gamma caused by incubation with simvastatin only, an observation suggesting that simultaneous administration of both substances may reduce inflammatory responses.	Lycopene	24-32	interleukin 18	Homo sapiens	178-187
20819671-0	2010	Effect of lycopene on androgen receptor and prostate-specific antigen velocity.	Lycopene	10-18	androgen receptor	Homo sapiens	22-39
20840669-13	2010	In vitro, increased expression of AKR1C2 and prostaglandin F2alpha correlated with cytoprotection against anticancer drugs and lycopene.	Lycopene	127-135	aldo-keto reductase family 1 member C2	Homo sapiens	34-40
20819671-0	2010	Effect of lycopene on androgen receptor and prostate-specific antigen velocity.	Lycopene	10-18	kallikrein related peptidase 3	Homo sapiens	44-69
20819671-16	2010	CONCLUSIONS: Lycopene as an antioxidant dietary factor could significantly inhibit DNA synthesis in a dose-dependent pattern; the result revealed lycopene might inhibit androgen receptor gene element activity and expression.	Lycopene	13-21	androgen receptor	Homo sapiens	169-186
20819671-16	2010	CONCLUSIONS: Lycopene as an antioxidant dietary factor could significantly inhibit DNA synthesis in a dose-dependent pattern; the result revealed lycopene might inhibit androgen receptor gene element activity and expression.	Lycopene	146-154	androgen receptor	Homo sapiens	169-186
20819671-2	2010	This study was carried out to evaluate the impact of the dietary factor lycopene on DNA synthesis, activity and expression of the androgen receptor gene element in prostate LnCaP cells and to report our pilot phase II study investigating its effect on prostate-specific antigen velocity over one year.	Lycopene	72-80	androgen receptor	Homo sapiens	130-147
20819671-5	2010	A transient transfection of a plasmid DNA recombinant containing an androgen receptor element-luciferase (ARE-Luc) report gene into LnCaP cells was developed and the impact of different concentrations of lycopene on the androgen receptor element was reflected by quantitative analysis of the luciferase enzyme function.	Lycopene	204-212	androgen receptor	Homo sapiens	220-237
20819671-7	2010	The phase II pilot study patients (n=41) previously diagnosed with prostate cancer were enrolled and given lycopene supplement, 10 mg per day, and response was measured by observing changes in the plasma prostate-specific antigen (PSA) levels.	Lycopene	107-115	kallikrein related peptidase 3	Homo sapiens	204-235
20819671-10	2010	We showed for the first time that lycopene inhibited the activity of the androgen receptor gene element in a dose-related manner.	Lycopene	34-42	androgen receptor	Homo sapiens	73-90
21485652-7	2010	With regard to 8-OHdG levels in non-tumorous liver tissue at 8 months of age, EGCG showed no significant inhibitory effects and lycopene showed significant inhibitory effects only in XPA +/- mice.	Lycopene	128-136	xeroderma pigmentosum, complementation group A	Mus musculus	183-186
20482279-0	2010	Effect of lycopene on caspase-3 enzyme activation in liver of methanol-intoxicated rats: comparison with fomepizole.	Lycopene	10-18	caspase 3	Rattus norvegicus	22-31
20482279-9	2010	Similarly, lycopene and fomepizole decreased methanol-induced caspase-3 activity.	Lycopene	11-19	caspase 3	Rattus norvegicus	62-71
20482279-12	2010	It was demonstrated for the first time that both lycopene and fomepizole prevent methanol-induced hepatic injury by reducing the increase of lipid oxidation and caspase-3 activation.	Lycopene	49-57	caspase 3	Rattus norvegicus	161-170
20392890-11	2010	Cell incubation with sera from men who consumed purified lycopene led to significant up-regulation of IGFBP-3, c-fos, and uPAR compared with sera collected after placebo consumption.	Lycopene	57-65	insulin like growth factor binding protein 3	Homo sapiens	102-109
20392890-11	2010	Cell incubation with sera from men who consumed purified lycopene led to significant up-regulation of IGFBP-3, c-fos, and uPAR compared with sera collected after placebo consumption.	Lycopene	57-65	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	111-116
20392890-11	2010	Cell incubation with sera from men who consumed purified lycopene led to significant up-regulation of IGFBP-3, c-fos, and uPAR compared with sera collected after placebo consumption.	Lycopene	57-65	plasminogen activator, urokinase receptor	Homo sapiens	122-126
20074268-7	2010	LP and EA treatments to AR-treated rats markedly decreased abnormal sperm rates, testicular thiobarbituric acid reactive substances level, and increased the glutathione (GSH) level, GSH-peroxidase, catalase activities and epidiymal sperm concentration as compared with the alone AR group.	Lycopene	0-2	catalase	Rattus norvegicus	198-206
20460582-2	2010	The reaction is catalyzed by lycopene beta-cyclase (LCY-B), which converts lycopene into beta-carotene, and by capsanthin-capsorubin synthase (CCS), which is mainly dedicated to the synthesis of kappa-cyclic carotenoids (capsanthin and capsorubin) but also has LCY-B activity.	Lycopene	29-37	lycopene beta cyclase, chloroplastic/chromoplastic	Capsicum annuum	52-57
20460582-2	2010	The reaction is catalyzed by lycopene beta-cyclase (LCY-B), which converts lycopene into beta-carotene, and by capsanthin-capsorubin synthase (CCS), which is mainly dedicated to the synthesis of kappa-cyclic carotenoids (capsanthin and capsorubin) but also has LCY-B activity.	Lycopene	29-37	lycopene beta cyclase, chloroplastic/chromoplastic	Capsicum annuum	261-266
20460582-2	2010	The reaction is catalyzed by lycopene beta-cyclase (LCY-B), which converts lycopene into beta-carotene, and by capsanthin-capsorubin synthase (CCS), which is mainly dedicated to the synthesis of kappa-cyclic carotenoids (capsanthin and capsorubin) but also has LCY-B activity.	Lycopene	75-83	lycopene beta cyclase, chloroplastic/chromoplastic	Capsicum annuum	52-57
20460582-2	2010	The reaction is catalyzed by lycopene beta-cyclase (LCY-B), which converts lycopene into beta-carotene, and by capsanthin-capsorubin synthase (CCS), which is mainly dedicated to the synthesis of kappa-cyclic carotenoids (capsanthin and capsorubin) but also has LCY-B activity.	Lycopene	75-83	lycopene beta cyclase, chloroplastic/chromoplastic	Capsicum annuum	261-266
20026158-5	2010	Treatment with lycopene, synbiotic or their combination significantly increased apoptosis, reduced the PCNA and p53 labeling indexes and the development of classical ACF and mucin-negative ACF.	Lycopene	15-23	proliferating cell nuclear antigen	Rattus norvegicus	103-107
20335404-4	2010	This step, mediated by a putative Z-ISO, was predicted to occur in the sequence of redox reactions that are coupled to an electron transport chain and convert the colorless 15-cis-phytoene to the red-colored all-trans-lycopene.	Lycopene	208-226	15-cis-zeta-carotene isomerase	Arabidopsis thaliana	34-39
19551842-5	2010	Results showed that both LY and TE supplementations significantly decreased the number of altered hepatic foci expressing the placental form of glutathione S-transferase in the livers of HFD-fed rats.	Lycopene	25-27	hematopoietic prostaglandin D synthase	Rattus norvegicus	144-169
20237770-6	2010	Lycopene reduced PDGF-AA signaling, including phosphorylation in PDGFR-alpha and its downstream protein kinases/enzymes.	Lycopene	0-8	platelet derived growth factor receptor alpha	Homo sapiens	65-76
27683352-0	2010	Antioxidant Effects of Lycopene and Ubiquinol-10 on the Oxidative Stress in Rat Hepatocytes Induced by Tert-Buthyl Hydroperoxide.	Lycopene	23-31	telomerase reverse transcriptase	Rattus norvegicus	103-107
20026158-5	2010	Treatment with lycopene, synbiotic or their combination significantly increased apoptosis, reduced the PCNA and p53 labeling indexes and the development of classical ACF and mucin-negative ACF.	Lycopene	15-23	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	112-115
20459036-10	2010	Compared with the model group and control group, the expression of HIF-1 alpha mRNA of cortex in the high dose lycopene (20 mg/kg bw) group was up-regulated; while the expression of Bcl-2 mRNA of cortex was up-regulated only in the low dose lycopene (5 mg/kg bw) group.	Lycopene	111-119	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	67-78
20449542-6	2010	When the lycopene pre-treated animals were challenged with DMBA, a decrease in micronucleated cell score was observed, which was in corroboration with the observed decrease in LDH and ALP activities and LPO levels.	Lycopene	9-17	alopecia, recessive	Mus musculus	184-187
20449542-6	2010	When the lycopene pre-treated animals were challenged with DMBA, a decrease in micronucleated cell score was observed, which was in corroboration with the observed decrease in LDH and ALP activities and LPO levels.	Lycopene	9-17	lactoperoxidase	Mus musculus	203-206
20459036-10	2010	Compared with the model group and control group, the expression of HIF-1 alpha mRNA of cortex in the high dose lycopene (20 mg/kg bw) group was up-regulated; while the expression of Bcl-2 mRNA of cortex was up-regulated only in the low dose lycopene (5 mg/kg bw) group.	Lycopene	111-119	BCL2, apoptosis regulator	Rattus norvegicus	182-187
20459036-10	2010	Compared with the model group and control group, the expression of HIF-1 alpha mRNA of cortex in the high dose lycopene (20 mg/kg bw) group was up-regulated; while the expression of Bcl-2 mRNA of cortex was up-regulated only in the low dose lycopene (5 mg/kg bw) group.	Lycopene	241-249	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	67-78
19693648-0	2010	Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-kappaB in macrophages.	Lycopene	0-8	interleukin 6	Mus musculus	39-43
19693648-0	2010	Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-kappaB in macrophages.	Lycopene	0-8	mitogen-activated protein kinase 1	Mus musculus	87-90
19693648-0	2010	Lycopene suppresses LPS-induced NO and IL-6 production by inhibiting the activation of ERK, p38MAPK, and NF-kappaB in macrophages.	Lycopene	0-8	mitogen-activated protein kinase 14	Mus musculus	92-99
19693648-3	2010	RESULTS: Lycopene inhibited LPS-induced production of nitric oxide (NO) and interleukin-6 (IL-6) with decreased mRNAs of inducible nitric oxide synthase and IL-6 but had no effect on TNF-alpha.	Lycopene	9-17	interleukin 6	Mus musculus	76-89
19693648-3	2010	RESULTS: Lycopene inhibited LPS-induced production of nitric oxide (NO) and interleukin-6 (IL-6) with decreased mRNAs of inducible nitric oxide synthase and IL-6 but had no effect on TNF-alpha.	Lycopene	9-17	interleukin 6	Mus musculus	91-95
19693648-3	2010	RESULTS: Lycopene inhibited LPS-induced production of nitric oxide (NO) and interleukin-6 (IL-6) with decreased mRNAs of inducible nitric oxide synthase and IL-6 but had no effect on TNF-alpha.	Lycopene	9-17	interleukin 6	Mus musculus	157-161
19693648-3	2010	RESULTS: Lycopene inhibited LPS-induced production of nitric oxide (NO) and interleukin-6 (IL-6) with decreased mRNAs of inducible nitric oxide synthase and IL-6 but had no effect on TNF-alpha.	Lycopene	9-17	tumor necrosis factor	Mus musculus	183-192
19693648-5	2010	Moreover, lycopene blocked the phosphorylation of ERK1/2 and p38 MAP kinase but not c-Jun NH(2)-terminal kinase.	Lycopene	10-18	mitogen-activated protein kinase 3	Mus musculus	50-56
19693648-5	2010	Moreover, lycopene blocked the phosphorylation of ERK1/2 and p38 MAP kinase but not c-Jun NH(2)-terminal kinase.	Lycopene	10-18	mitogen-activated protein kinase 14	Mus musculus	61-64
19693648-8	2010	CONCLUSION: Lycopene inhibits the inflammatory response of RAW 264.7 cells to LPS through inhibiting ERK/p38 MAP kinase and the NF-kappaB pathway.	Lycopene	12-20	mitogen-activated protein kinase 1	Mus musculus	101-104
19693648-8	2010	CONCLUSION: Lycopene inhibits the inflammatory response of RAW 264.7 cells to LPS through inhibiting ERK/p38 MAP kinase and the NF-kappaB pathway.	Lycopene	12-20	mitogen-activated protein kinase 14	Mus musculus	105-108
20664283-0	2010	Paraoxonase 1 polymorphisms 172T A and 584A G modify the association between serum concentrations of the antioxidant lycopene and bone turnover markers and oxidative stress parameters in women 25-70 years of age.	Lycopene	117-125	paraoxonase 1	Homo sapiens	0-13
19157829-6	2010	Lycopene prevented the arrest in G0/G1 phase of cell cycle induced by the oxysterol and counteracted the increased expression of p53 and p21.	Lycopene	0-8	tumor protein p53	Homo sapiens	129-132
19157829-6	2010	Lycopene prevented the arrest in G0/G1 phase of cell cycle induced by the oxysterol and counteracted the increased expression of p53 and p21.	Lycopene	0-8	H3 histone pseudogene 16	Homo sapiens	137-140
20664283-3	2010	The aim of this study was to determine whether PON1 genotypes modified the association between lycopene and bone turnover markers and oxidative stress parameters.	Lycopene	95-103	paraoxonase 1	Homo sapiens	47-51
20664283-10	2010	CONCLUSIONS: These findings show that PON1 polymorphisms modify the association between serum concentrations of lycopene and oxidative stress parameters and bone turnover markers and may, therefore, moderate the risk of osteoporosis.	Lycopene	112-120	paraoxonase 1	Homo sapiens	38-42
19886649-6	2009	Comparatively, ROO-beta-CAR(*) is less likely to react with O(2) than ROO-LYC(*).	Lycopene	74-77	CXADR pseudogene 1	Homo sapiens	24-27
20046059-5	2010	For example, SAMP1 line is used to study the anti-aging effect of the antioxidant containing foods and various anti-oxidants, such as coenzyme Q10, vitamin C, lycopene.	Lycopene	159-167	transmembrane protein 201	Mus musculus	13-18
20975915-7	2009	In the present study, five antioxidants, namely lycopene, ascorbic acid, alpha-tocopherol, curcumin and curcumin dipiperoyl ester which are potent scavengers of reactive oxygen species (ROS) have been docked to HIF-1 alpha modeled protein in order to assess their binding and consequently, their inhibitory activity.	Lycopene	48-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	211-222
19915967-2	2009	In this study, we investigated the effects of lycopene on the oxidative injury and apoptosis of endothelial cells induced by H(2)O(2), and the effects of lycopene on the expression of p53, caspase-3 mRNA in injured cells.	Lycopene	154-162	tumor protein p53	Homo sapiens	184-187
20553078-10	2009	Serum IGFBP-3 levels decreased with increasing serum lycopene levels in women and with increasing serum zeaxanthin/lutein levels in men.	Lycopene	53-61	insulin like growth factor binding protein 3	Homo sapiens	6-13
19915967-11	2009	Similarly, lycopene significantly diminished the apoptosis ratio of oxidative injured cells, and also downregulated the expressions of p53 and caspase-3 mRNA induced by H(2)O(2).	Lycopene	11-19	tumor protein p53	Homo sapiens	135-138
19915967-11	2009	Similarly, lycopene significantly diminished the apoptosis ratio of oxidative injured cells, and also downregulated the expressions of p53 and caspase-3 mRNA induced by H(2)O(2).	Lycopene	11-19	caspase 3	Homo sapiens	143-152
19915967-13	2009	CONCLUSIONS: Lycopene can decrease the oxidative injury of endothelial cells induced by H(2)O(2), can attenuate the expression of p53 and caspase-3 mRNA in injured cells, and can diminish the apoptosis of injured cells.	Lycopene	13-21	tumor protein p53	Homo sapiens	130-133
19915967-13	2009	CONCLUSIONS: Lycopene can decrease the oxidative injury of endothelial cells induced by H(2)O(2), can attenuate the expression of p53 and caspase-3 mRNA in injured cells, and can diminish the apoptosis of injured cells.	Lycopene	13-21	caspase 3	Homo sapiens	138-147
19723106-3	2009	In the present study, we aim to investigate whether lycopene protects oxidative stress-induced cell death of pancreatic acinar AR42J cells by preventing the loss of Ku70 in the nucleus.	Lycopene	52-60	X-ray repair cross complementing 6	Rattus norvegicus	165-169
19664603-0	2009	Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppression of PI3K/Akt and MAPK pathways.	Lycopene	0-8	AKT serine/threonine kinase 1	Homo sapiens	99-102
19664603-6	2009	Lycopene shows no effect on ARPE19 cell adhesion and is found to inhibit PDGF-BB-induced tyrosine phosphorylation and the underlying signaling pathways of PI3K, Akt, ERK and p38 activation.	Lycopene	0-8	AKT serine/threonine kinase 1	Homo sapiens	161-164
19664603-6	2009	Lycopene shows no effect on ARPE19 cell adhesion and is found to inhibit PDGF-BB-induced tyrosine phosphorylation and the underlying signaling pathways of PI3K, Akt, ERK and p38 activation.	Lycopene	0-8	mitogen-activated protein kinase 1	Homo sapiens	166-169
19664603-6	2009	Lycopene shows no effect on ARPE19 cell adhesion and is found to inhibit PDGF-BB-induced tyrosine phosphorylation and the underlying signaling pathways of PI3K, Akt, ERK and p38 activation.	Lycopene	0-8	mitogen-activated protein kinase 14	Homo sapiens	174-177
19664603-8	2009	Taken together, our results demonstrate that lycopene inhibits PDGF-BB-induced ARPE19 cell migration through inhibition of PI3K/Akt, ERK and p38 activation.	Lycopene	45-53	AKT serine/threonine kinase 1	Homo sapiens	128-131
19664603-8	2009	Taken together, our results demonstrate that lycopene inhibits PDGF-BB-induced ARPE19 cell migration through inhibition of PI3K/Akt, ERK and p38 activation.	Lycopene	45-53	mitogen-activated protein kinase 1	Homo sapiens	133-136
19664603-8	2009	Taken together, our results demonstrate that lycopene inhibits PDGF-BB-induced ARPE19 cell migration through inhibition of PI3K/Akt, ERK and p38 activation.	Lycopene	45-53	mitogen-activated protein kinase 14	Homo sapiens	141-144
19452524-7	2009	Ibuprofen-type drugs, IL6 polymorphisms (rs1800796) and dietary alpha-tocopherol and lycopene significantly altered likelihood of having a TP53 mutation.	Lycopene	85-93	tumor protein p53	Homo sapiens	139-143
20030056-1	2009	OBJECTIVE: Lycopene epsilon cyclase (LCYE) is the key enzyme in the lutein synthesis pathway and catalyses linear lycopene to form cyclic epsilon-carotene, a presucursor of lutein.	Lycopene	114-122	uncharacterized protein	Chlamydomonas reinhardtii	37-41
20030056-6	2009	Furthermore, the E. coli strain containing the pAC-LYC plasmid which could accumulate lycopene was used for the functional confirmation of LCYE from C. protothecoides CS-41.	Lycopene	86-94	uncharacterized protein	Chlamydomonas reinhardtii	139-143
19627101-6	2009	In nonpolar environments the reactivity of the studied carotenoids toward peroxyl radical follows the trend LYC &gt; TOR &gt; BC, whereas in aqueous solutions it is TOR &gt; LYC &gt; BC.	Lycopene	108-111	RAR related orphan receptor C	Homo sapiens	117-120
19723106-7	2009	Lycopene inhibited glucose/glucose oxidase-induced cell death by preventing nuclear loss of Ku70 and a decrease in Ku-DNA-binding activity of AR42J cells.	Lycopene	0-8	X-ray repair cross complementing 6	Rattus norvegicus	92-96
19723106-8	2009	In conclusion, lycopene may be beneficial for the treatment of oxidative stress-induced cell death by preventing loss of DNA repair protein Ku70.	Lycopene	15-23	X-ray repair cross complementing 6	Rattus norvegicus	140-144
19447983-5	2009	Results showed that the accumulation of the tocopherol and lycopene into mixed micelles in MFGM-stabilized emulsions was around 2-fold greater than in emulsions stabilized with conventional milk proteins.	Lycopene	59-67	milk fat globule EGF and factor V/VIII domain containing	Bos taurus	91-95
18824341-8	2009	Preincubation of airway epithelial cells with lycopene (dissolved in tetrahydrofuran) delivered lycopene into the cells and resulted in a 24% reduction in interleukin-6 after rhinovirus-1B infection, 31% reduction in IP-10 after rhinovirus-43 infection and 85% reduction in rhinovirus-1B replication.	Lycopene	46-54	interleukin 6	Homo sapiens	155-168
18824341-8	2009	Preincubation of airway epithelial cells with lycopene (dissolved in tetrahydrofuran) delivered lycopene into the cells and resulted in a 24% reduction in interleukin-6 after rhinovirus-1B infection, 31% reduction in IP-10 after rhinovirus-43 infection and 85% reduction in rhinovirus-1B replication.	Lycopene	46-54	C-X-C motif chemokine ligand 10	Homo sapiens	217-222
19384236-7	2009	Among participants with CIMT&gt; or =0.8 mm, body mass index, blood pressures, total cholesterol, LDL cholesterol, triglycerides, uric acid, C-reactive protein, and fibrinogen were significantly higher, whereas concentrations of vitamin A, vitamin E, lycopene, and beta-carotene were all significantly lower when compared with participants who did not show evidence of carotid atherosclerosis (P&lt;0.001).	Lycopene	251-259	fibrinogen beta chain	Homo sapiens	165-175
18824341-9	2009	Lycopene also decreased the release of IL-6 and IP-10 following exposure to lipopolysaccharide.	Lycopene	0-8	interleukin 6	Homo sapiens	39-43
18824341-9	2009	Lycopene also decreased the release of IL-6 and IP-10 following exposure to lipopolysaccharide.	Lycopene	0-8	C-X-C motif chemokine ligand 10	Homo sapiens	48-53
19392686-5	2009	A similar carotene cyclization profile is seen when LcyE is introduced into lycopene-accumulating Escherichia coli cells, suggesting that the carotenoid profile in the endosperm tissue of the lcyB mutant is largely due to the activity of LCYE in the absence of LCYB.	Lycopene	76-84	Lycopene epsilon cyclase, chloroplastic	Zea mays	52-56
19121922-1	2009	OBJECTIVE: We tested the hypothesis that lycopene supplementation reduces the expression of oxidant-responsive heme oxygenase-1 (HO-1) in basal conditions and in response to an oxidant challenge and determined whether this is temporally associated with increased cell viability.	Lycopene	41-49	heme oxygenase 1	Homo sapiens	111-127
18708285-11	2009	Furthermore, treatment of lycopene and EPA also synergistically blocked the activation of downstream mTOR molecule.	Lycopene	26-34	mechanistic target of rapamycin kinase	Homo sapiens	101-105
18708285-12	2009	Immunocytochemical staining results revealed that lycopene and EPA could also up-regulate the expression of apoptotic proteins such as Bax and Fas ligand to suppress cell survival.	Lycopene	50-58	BCL2 associated X, apoptosis regulator	Homo sapiens	135-138
18708285-12	2009	Immunocytochemical staining results revealed that lycopene and EPA could also up-regulate the expression of apoptotic proteins such as Bax and Fas ligand to suppress cell survival.	Lycopene	50-58	Fas ligand	Homo sapiens	143-153
18708285-14	2009	The inhibitory effects of lycopene and EPA on cell proliferation of human colon cancer HT-29 cells were, in part, associated with the down-regulation of the PI-3K/Akt/mTOR signaling pathway.	Lycopene	26-34	AKT serine/threonine kinase 1	Homo sapiens	163-166
18708285-14	2009	The inhibitory effects of lycopene and EPA on cell proliferation of human colon cancer HT-29 cells were, in part, associated with the down-regulation of the PI-3K/Akt/mTOR signaling pathway.	Lycopene	26-34	mechanistic target of rapamycin kinase	Homo sapiens	167-171
19121922-1	2009	OBJECTIVE: We tested the hypothesis that lycopene supplementation reduces the expression of oxidant-responsive heme oxygenase-1 (HO-1) in basal conditions and in response to an oxidant challenge and determined whether this is temporally associated with increased cell viability.	Lycopene	41-49	heme oxygenase 1	Homo sapiens	129-133
19121922-2	2009	METHODS: We determined basal and stimulated ex vivo expression of HO-1 and cell viability in lymphocytes from volunteers after lycopene supplementation.	Lycopene	127-135	heme oxygenase 1	Homo sapiens	66-70
18662427-8	2009	Plasma lycopene concentrations were significantly different (P &lt; 0.05) in women who had different SNP variants in intestinal fatty acid binding protein (I-FABP).	Lycopene	7-15	fatty acid binding protein 2	Homo sapiens	117-154
18662427-8	2009	Plasma lycopene concentrations were significantly different (P &lt; 0.05) in women who had different SNP variants in intestinal fatty acid binding protein (I-FABP).	Lycopene	7-15	fatty acid binding protein 2	Homo sapiens	156-162
20067883-11	2009	The antiproliferative action of lycopene alone and in combination with docetaxel was also confirmed in immunohistochemical examination (decreased the percentage of PCNA and Ki67 positive cells).	Lycopene	32-40	proliferating cell nuclear antigen	Homo sapiens	164-168
20067883-12	2009	Also retinol (10 muM) and lycopene (20 and 50 muM) combined with estradiol (0.01 muM) statistically decreased the percentage of proliferating cells compared to the control (p&lt;0.0001) and estradiol (p&lt;0.01, p&lt;0.0001) group (63.5%+/-14.8, 61.0%+/-20.6, 15.0%+/-5.5 respectively).	Lycopene	26-34	latexin	Homo sapiens	46-49
20067883-5	2009	The aim of the study was to determine the effects of vitamin A family compounds (retinol, beta-carotene, lycopene, all-trans -, 9-cis - and 13-cis retinoic acid) on the growth and proliferation of CRL-11731 endometrioid ovary cancer cell line and on docetaxel and estradiol activity in this culture.	Lycopene	105-113	interleukin 31 receptor A	Homo sapiens	197-200
20067883-12	2009	Also retinol (10 muM) and lycopene (20 and 50 muM) combined with estradiol (0.01 muM) statistically decreased the percentage of proliferating cells compared to the control (p&lt;0.0001) and estradiol (p&lt;0.01, p&lt;0.0001) group (63.5%+/-14.8, 61.0%+/-20.6, 15.0%+/-5.5 respectively).	Lycopene	26-34	latexin	Homo sapiens	46-49
20067883-15	2009	beta-carotene, lycopene and all-trans retinoic acid alone and in combination with docetaxel were found to influence the expression of bcl-2 and p53 antigen in the cells examined.	Lycopene	15-23	BCL2 apoptosis regulator	Homo sapiens	134-139
20067883-15	2009	beta-carotene, lycopene and all-trans retinoic acid alone and in combination with docetaxel were found to influence the expression of bcl-2 and p53 antigen in the cells examined.	Lycopene	15-23	tumor protein p53	Homo sapiens	144-147
20155615-7	2009	Lycopene modulates several of the aforementioned pathways, providing a promising rationale for prostate cancer risk reduction by lycopene: In many experimental setups, lycopene reduced inflammatory signals, prevented oxidative DNA damage, modulated the expression or activity of IGF axis members, of Wnt/beta-catenin and androgen signalling, and enhanced gap junctional communication.	Lycopene	0-8	catenin beta 1	Homo sapiens	304-316
20155615-7	2009	Lycopene modulates several of the aforementioned pathways, providing a promising rationale for prostate cancer risk reduction by lycopene: In many experimental setups, lycopene reduced inflammatory signals, prevented oxidative DNA damage, modulated the expression or activity of IGF axis members, of Wnt/beta-catenin and androgen signalling, and enhanced gap junctional communication.	Lycopene	168-176	catenin beta 1	Homo sapiens	304-316
19164258-7	2009	beta-Cryptoxanthin, lycopene, and lutein/zeaxanthin concentrations were inversely related to interleukin-6 concentrations.	Lycopene	20-28	interleukin 6	Homo sapiens	93-106
19071209-0	2009	Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats.	Lycopene	34-42	steroidogenic acute regulatory protein	Rattus norvegicus	111-115
19901932-6	2009	An inverse association was observed between lycopene intake and PSA levels in six studies.	Lycopene	44-52	aminopeptidase puromycin sensitive	Homo sapiens	64-67
19071209-0	2009	Studies on the protective role of lycopene against polychlorinated biphenyls (Aroclor 1254)-induced changes in StAR protein and cytochrome P450 scc enzyme expression on Leydig cells of adult rats.	Lycopene	34-42	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	128-147
19071209-5	2009	The present study was conducted to elucidate the protective role of lycopene against Aroclor 1254-induced changes in Leydig cellular steroidogenic acute regulatory (StAR) protein, cytochrome P450 side chain cleavage (P450 scc) enzyme expression and 3beta-hydroxy steroid dehydrogenase (3beta-HSD) activity.	Lycopene	68-76	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	249-284
19071209-5	2009	The present study was conducted to elucidate the protective role of lycopene against Aroclor 1254-induced changes in Leydig cellular steroidogenic acute regulatory (StAR) protein, cytochrome P450 side chain cleavage (P450 scc) enzyme expression and 3beta-hydroxy steroid dehydrogenase (3beta-HSD) activity.	Lycopene	68-76	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	286-295
19071209-21	2009	However, simultaneous supplementation of lycopene improved Leydig cellular StAR protein, cytochrome P450 scc expression and activity of 3beta-HSD.	Lycopene	41-49	steroidogenic acute regulatory protein	Rattus norvegicus	75-79
19071209-21	2009	However, simultaneous supplementation of lycopene improved Leydig cellular StAR protein, cytochrome P450 scc expression and activity of 3beta-HSD.	Lycopene	41-49	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	89-108
19071209-21	2009	However, simultaneous supplementation of lycopene improved Leydig cellular StAR protein, cytochrome P450 scc expression and activity of 3beta-HSD.	Lycopene	41-49	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	136-145
18638450-0	2008	Lycopene suppresses ovalbumin-induced airway inflammation in a murine model of asthma.	Lycopene	0-8	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	20-29
18930254-7	2008	A significant decrease in prostate specific antigen was observed in some studies using a low fat vegan diet, soy beverage or lycopene supplement.	Lycopene	125-133	kallikrein related peptidase 3	Homo sapiens	26-51
18682897-7	2008	The activities of SOD, CAT, and GPx were found to be significantly high than lyco alone treated rats.	Lycopene	77-81	catalase	Rattus norvegicus	23-26
18784358-10	2008	However, men with the MnSOD Ala/Ala genotype who had low long-term lycopene status had a higher risk of aggressive prostate cancer compared with individuals with the other genotypes.	Lycopene	67-75	superoxide dismutase 2	Homo sapiens	22-27
19022959-1	2008	15,15"-carotenoid monooxygenase (CMO I) is generally recognized as the central carotenoid cleavage enzyme responsible for converting provitamin A carotenoids to vitamin A, while having little affinity for nonprovitamin A carotenoids, such as lycopene.	Lycopene	242-250	beta-carotene oxygenase 1	Mus musculus	33-38
19022959-3	2008	CMO I KO mice fed lycopene (Lyc-KO) exhibited significant decreases in hepatic, spleen, and thymus lycopene concentrations and significant increases in prostate, seminal vesicles, testes, and brain lycopene concentrations compared with WT mice fed lycopene (Lyc-WT).	Lycopene	18-26	beta-carotene oxygenase 1	Mus musculus	0-5
19022959-3	2008	CMO I KO mice fed lycopene (Lyc-KO) exhibited significant decreases in hepatic, spleen, and thymus lycopene concentrations and significant increases in prostate, seminal vesicles, testes, and brain lycopene concentrations compared with WT mice fed lycopene (Lyc-WT).	Lycopene	99-107	beta-carotene oxygenase 1	Mus musculus	0-5
19022959-3	2008	CMO I KO mice fed lycopene (Lyc-KO) exhibited significant decreases in hepatic, spleen, and thymus lycopene concentrations and significant increases in prostate, seminal vesicles, testes, and brain lycopene concentrations compared with WT mice fed lycopene (Lyc-WT).	Lycopene	99-107	beta-carotene oxygenase 1	Mus musculus	0-5
19022959-3	2008	CMO I KO mice fed lycopene (Lyc-KO) exhibited significant decreases in hepatic, spleen, and thymus lycopene concentrations and significant increases in prostate, seminal vesicles, testes, and brain lycopene concentrations compared with WT mice fed lycopene (Lyc-WT).	Lycopene	99-107	beta-carotene oxygenase 1	Mus musculus	0-5
19022959-8	2008	In conclusion, CMO I KO mice fed low levels of vitamin A have altered lycopene biodistribution and isomer patterns and do not cleave beta-carotene to vitamin A at appreciable levels.	Lycopene	70-78	beta-carotene oxygenase 1	Mus musculus	15-20
18930254-8	2008	While not often reported as an end point, a significant increase in prostate specific antigen doubling time was observed in a study on lycopene supplementation.	Lycopene	135-143	kallikrein related peptidase 3	Homo sapiens	68-93
18638450-1	2008	In this study, we attempt to determine whether lycopene regulates inflammatory mediators in the ovalbumin (OVA)-induced murine asthma model.	Lycopene	47-55	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	96-105
18638450-4	2008	Administration of lycopene also resulted in a significant inhibition of the infiltration of inflammatory immunocytes into the bronchoalveolar lavage, and attenuated the gelatinolytic activity of matrix metalloproteinase-9 and the expression of eosinophil peroxidase.	Lycopene	18-26	matrix metallopeptidase 9	Mus musculus	195-221
18638450-4	2008	Administration of lycopene also resulted in a significant inhibition of the infiltration of inflammatory immunocytes into the bronchoalveolar lavage, and attenuated the gelatinolytic activity of matrix metalloproteinase-9 and the expression of eosinophil peroxidase.	Lycopene	18-26	eosinophil peroxidase	Mus musculus	244-265
18638450-5	2008	Additionally, lycopene reduced the increased levels of GATA-3 mRNA level and IL-4 expression in OVA-challenged mice.	Lycopene	14-22	GATA binding protein 3	Mus musculus	55-61
18638450-5	2008	Additionally, lycopene reduced the increased levels of GATA-3 mRNA level and IL-4 expression in OVA-challenged mice.	Lycopene	14-22	interleukin 4	Mus musculus	77-81
18638450-6	2008	However, it increased T-bet mRNA level and IFN-gamma expression in lycopene-challenged mice.	Lycopene	67-75	T-box 21	Mus musculus	22-27
18638450-6	2008	However, it increased T-bet mRNA level and IFN-gamma expression in lycopene-challenged mice.	Lycopene	67-75	interferon gamma	Mus musculus	43-52
19513255-1	2008	Fruits harvested from tomato (Solanum lycopersicum) plants carrying mutations at the DAMAGED DNA BINDING PROTEIN 1 gene (SlDDB1; hp-1 and hp-1(w)) are characterized by significantly elevated levels of lycopene and several other phytonutrients.	Lycopene	201-209	DNA damage-binding protein 1	Solanum lycopersicum	121-127
18566994-0	2008	Enzymatic metabolites of lycopene induce Nrf2-mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells.	Lycopene	25-33	NFE2 like bZIP transcription factor 2	Homo sapiens	41-45
18566994-7	2008	These data strongly suggest that the anti-carcinogenic and antioxidant functions of lycopene may be mediated by apo-10"-lycopenoids via activating Nrf2 and inducing phase II detoxifying/antioxidant enzymes.	Lycopene	84-92	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
18713349-6	2008	Therefore, in ACS-suppression transgenic tomato fruits, the low levels of 6-methyl-5-hepten-2-one, 6-methyl-5-hepten-2-ol was due to decreased lycopene accumulation, not ethylene production.	Lycopene	143-151	1-aminocyclopropane-1-carboxylate synthase 2	Solanum lycopersicum	14-17
18537129-8	2008	Lycopene treatment suppressed Akt activation and non-phosphorylated beta-catenin protein level in human colon cancer cells.	Lycopene	0-8	catenin beta 1	Homo sapiens	68-80
18641187-0	2008	Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1.	Lycopene	0-8	scavenger receptor class B, member 1	Mus musculus	67-100
18641187-2	2008	The aim of this work was therefore to determine whether SR-BI and NPC1L1 (Niemann-Pick C1-like 1), another cholesterol transporter, are implicated in absorption of lycopene, the 3rd main carotenoid of the human diet.	Lycopene	164-172	scavenger receptor class B member 1	Homo sapiens	56-61
18641187-2	2008	The aim of this work was therefore to determine whether SR-BI and NPC1L1 (Niemann-Pick C1-like 1), another cholesterol transporter, are implicated in absorption of lycopene, the 3rd main carotenoid of the human diet.	Lycopene	164-172	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	66-72
18641187-2	2008	The aim of this work was therefore to determine whether SR-BI and NPC1L1 (Niemann-Pick C1-like 1), another cholesterol transporter, are implicated in absorption of lycopene, the 3rd main carotenoid of the human diet.	Lycopene	164-172	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	74-96
18641187-5	2008	Plasma lycopene concentrations were approximately 10-fold higher (P &lt; 0.001) in mice overexpressing SR-BI in the intestine than in wild-type mice, confirming the involvement of SR-BI in lycopene absorption.	Lycopene	7-15	scavenger receptor class B, member 1	Mus musculus	103-108
18641187-5	2008	Plasma lycopene concentrations were approximately 10-fold higher (P &lt; 0.001) in mice overexpressing SR-BI in the intestine than in wild-type mice, confirming the involvement of SR-BI in lycopene absorption.	Lycopene	189-197	scavenger receptor class B, member 1	Mus musculus	180-185
18641187-8	2008	Thus, the present data show that lycopene absorption is, at least in part, mediated by SR-BI but not by NPC1L1.	Lycopene	33-41	scavenger receptor class B member 1	Homo sapiens	87-92
18055235-3	2008	The aim of the present study was to explore the antinociceptive effect of lycopene and its effect on tumour necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) release in streptozotocin induced diabetic mice.	Lycopene	74-82	tumor necrosis factor	Mus musculus	131-140
18055235-7	2008	Lycopene also inhibited the TNF-alpha and NO release in a dose dependent manner.	Lycopene	0-8	tumor necrosis factor	Mus musculus	28-37
18055235-8	2008	These results indicate an antinociceptive activity of lycopene possibly through its inhibitory action on NO and TNF-alpha release and point towards its potential to attenuate diabetic neuropathic pain.	Lycopene	54-62	tumor necrosis factor	Mus musculus	112-121
18567756-0	2008	High dose lycopene supplementation increases hepatic cytochrome P4502E1 protein and inflammation in alcohol-fed rats.	Lycopene	10-18	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	53-71
18567756-9	2008	Notably, lycopene supplementation at the higher dose significantly induced hepatic CYP2E1 protein, TNFalpha mRNA, and the incidence of inflammatory foci in the alcohol-fed rats but not in the control rats.	Lycopene	9-17	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	83-89
18567756-9	2008	Notably, lycopene supplementation at the higher dose significantly induced hepatic CYP2E1 protein, TNFalpha mRNA, and the incidence of inflammatory foci in the alcohol-fed rats but not in the control rats.	Lycopene	9-17	tumor necrosis factor	Rattus norvegicus	99-107
18537129-0	2008	Lycopene inhibits growth of human colon cancer cells via suppression of the Akt signaling pathway.	Lycopene	0-8	AKT serine/threonine kinase 1	Homo sapiens	76-79
18537129-6	2008	Thus we investigated the inhibitory effects of lycopene on the Akt signaling pathway in human colon cancer HT-29 cells.	Lycopene	47-55	AKT serine/threonine kinase 1	Homo sapiens	63-66
18537129-8	2008	Lycopene treatment suppressed Akt activation and non-phosphorylated beta-catenin protein level in human colon cancer cells.	Lycopene	0-8	AKT serine/threonine kinase 1	Homo sapiens	30-33
18537129-9	2008	Immunocytochemical results indicated that lycopene increased the phosphorylated form of beta-catenin proteins.	Lycopene	42-50	catenin beta 1	Homo sapiens	88-100
18537129-11	2008	Furthermore, lycopene significantly increased nuclear cyclin-dependent kinase inhibitor p27(kip)abundance and inhibited phosphorylation of the retinoblastoma tumor suppressor protein in human colon cancer cells.	Lycopene	13-21	interferon alpha inducible protein 27	Homo sapiens	88-91
18537129-12	2008	In conclusion, lycopene inhibited cell proliferation of human colon cancer cells via suppression of the Akt signaling pathway and downstream targeted molecules.	Lycopene	15-23	AKT serine/threonine kinase 1	Homo sapiens	104-107
18439578-10	2008	Taken together, we provided here the first evidence showing that lycopene is able to inhibit TNF-alpha-induced NF-kappaB activation, ICAM-1 expression, and monocyte-endothelial interaction, suggesting an anti-inflammatory role of lycopene and possibly explaining in part why lycopene can prevent cardiovascular diseases.	Lycopene	65-73	tumor necrosis factor	Homo sapiens	93-102
18439578-10	2008	Taken together, we provided here the first evidence showing that lycopene is able to inhibit TNF-alpha-induced NF-kappaB activation, ICAM-1 expression, and monocyte-endothelial interaction, suggesting an anti-inflammatory role of lycopene and possibly explaining in part why lycopene can prevent cardiovascular diseases.	Lycopene	65-73	nuclear factor kappa B subunit 1	Homo sapiens	111-120
18439578-0	2008	Lycopene inhibits TNF-alpha-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion.	Lycopene	0-8	tumor necrosis factor	Homo sapiens	18-27
18439578-10	2008	Taken together, we provided here the first evidence showing that lycopene is able to inhibit TNF-alpha-induced NF-kappaB activation, ICAM-1 expression, and monocyte-endothelial interaction, suggesting an anti-inflammatory role of lycopene and possibly explaining in part why lycopene can prevent cardiovascular diseases.	Lycopene	65-73	intercellular adhesion molecule 1	Homo sapiens	133-139
18439578-0	2008	Lycopene inhibits TNF-alpha-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion.	Lycopene	0-8	intercellular adhesion molecule 1	Homo sapiens	48-54
18439578-10	2008	Taken together, we provided here the first evidence showing that lycopene is able to inhibit TNF-alpha-induced NF-kappaB activation, ICAM-1 expression, and monocyte-endothelial interaction, suggesting an anti-inflammatory role of lycopene and possibly explaining in part why lycopene can prevent cardiovascular diseases.	Lycopene	230-238	tumor necrosis factor	Homo sapiens	93-102
18439578-4	2008	In the present study, we studied the effect of lycopene on TNF-alpha-induced signaling in human umbilical endothelial cells (HUVECs).	Lycopene	47-55	tumor necrosis factor	Homo sapiens	59-68
18439578-10	2008	Taken together, we provided here the first evidence showing that lycopene is able to inhibit TNF-alpha-induced NF-kappaB activation, ICAM-1 expression, and monocyte-endothelial interaction, suggesting an anti-inflammatory role of lycopene and possibly explaining in part why lycopene can prevent cardiovascular diseases.	Lycopene	230-238	tumor necrosis factor	Homo sapiens	93-102
18439578-5	2008	We found that TNF-alpha-induced intercellular adhesion molecule-1 (ICAM-1) expression in HUVECs was inhibited by lycopene, whereas cyclooxygenase-2 (COX-2) and platelet-endothelial cell adhesion molecule (PECAM-1) expression were not affected.	Lycopene	113-121	tumor necrosis factor	Homo sapiens	14-23
18439578-5	2008	We found that TNF-alpha-induced intercellular adhesion molecule-1 (ICAM-1) expression in HUVECs was inhibited by lycopene, whereas cyclooxygenase-2 (COX-2) and platelet-endothelial cell adhesion molecule (PECAM-1) expression were not affected.	Lycopene	113-121	intercellular adhesion molecule 1	Homo sapiens	32-65
18167141-2	2008	Its colour is due to the high content of lycopene whose synthesis is activated by the phytoene synthase 1 (PSY1) enzyme, encoded by Psy1 which is distinct from Psy2.	Lycopene	41-49	phytoene synthase 1, chloroplastic	Solanum lycopersicum	107-111
18439578-5	2008	We found that TNF-alpha-induced intercellular adhesion molecule-1 (ICAM-1) expression in HUVECs was inhibited by lycopene, whereas cyclooxygenase-2 (COX-2) and platelet-endothelial cell adhesion molecule (PECAM-1) expression were not affected.	Lycopene	113-121	intercellular adhesion molecule 1	Homo sapiens	67-73
18439578-6	2008	A further analysis indicated that lycopene attenuated TNF-alpha-induced IkappaB phosphorylation, NF-kappaB expression, and NF-kappaB p65 translocation from cytosol to nucleus.	Lycopene	34-42	tumor necrosis factor	Homo sapiens	54-63
18439578-6	2008	A further analysis indicated that lycopene attenuated TNF-alpha-induced IkappaB phosphorylation, NF-kappaB expression, and NF-kappaB p65 translocation from cytosol to nucleus.	Lycopene	34-42	nuclear factor kappa B subunit 1	Homo sapiens	97-106
18439578-6	2008	A further analysis indicated that lycopene attenuated TNF-alpha-induced IkappaB phosphorylation, NF-kappaB expression, and NF-kappaB p65 translocation from cytosol to nucleus.	Lycopene	34-42	nuclear factor kappa B subunit 1	Homo sapiens	123-132
18439578-6	2008	A further analysis indicated that lycopene attenuated TNF-alpha-induced IkappaB phosphorylation, NF-kappaB expression, and NF-kappaB p65 translocation from cytosol to nucleus.	Lycopene	34-42	RELA proto-oncogene, NF-kB subunit	Homo sapiens	133-136
18439578-7	2008	In line with this, TNF-alpha-induced NF-kappaB-DNA but not AP1-DNA complexes formation was inhibited by lycopene, as determined by the electrophoretic mobility shift assay (EMSA).	Lycopene	104-112	tumor necrosis factor	Homo sapiens	19-28
18439578-7	2008	In line with this, TNF-alpha-induced NF-kappaB-DNA but not AP1-DNA complexes formation was inhibited by lycopene, as determined by the electrophoretic mobility shift assay (EMSA).	Lycopene	104-112	nuclear factor kappa B subunit 1	Homo sapiens	37-46
18283040-0	2008	Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells.	Lycopene	0-8	insulin like growth factor 1	Homo sapiens	18-23
18283040-0	2008	Lycopene inhibits IGF-I signal transduction and growth in normal prostate epithelial cells by decreasing DHT-modulated IGF-I production in co-cultured reactive stromal cells.	Lycopene	0-8	insulin like growth factor 1	Homo sapiens	119-124
18283040-10	2008	Lycopene consumption is inversely related to human prostate cancer risk and inhibits IGF-I and androgen signaling in rat prostate cancer.	Lycopene	0-8	insulin like growth factor 1	Homo sapiens	85-90
18283040-11	2008	In this study, lycopene, in dietary concentrations, reversed DHT effects of 6S cells on NPE cell death, decreased 6S cell IGF-I production by reducing AR and beta-catenin nuclear localization and inhibited IGF-I-stimulated NPE and PREC growth, perhaps by attenuating IGF-I"s effects on serine phosphorylation of Akt and GSK3beta and tyrosine phosphorylation of GSK3.	Lycopene	15-23	insulin like growth factor 1	Homo sapiens	122-127
18283040-11	2008	In this study, lycopene, in dietary concentrations, reversed DHT effects of 6S cells on NPE cell death, decreased 6S cell IGF-I production by reducing AR and beta-catenin nuclear localization and inhibited IGF-I-stimulated NPE and PREC growth, perhaps by attenuating IGF-I"s effects on serine phosphorylation of Akt and GSK3beta and tyrosine phosphorylation of GSK3.	Lycopene	15-23	androgen receptor	Homo sapiens	151-153
18283040-11	2008	In this study, lycopene, in dietary concentrations, reversed DHT effects of 6S cells on NPE cell death, decreased 6S cell IGF-I production by reducing AR and beta-catenin nuclear localization and inhibited IGF-I-stimulated NPE and PREC growth, perhaps by attenuating IGF-I"s effects on serine phosphorylation of Akt and GSK3beta and tyrosine phosphorylation of GSK3.	Lycopene	15-23	catenin beta 1	Homo sapiens	158-170
18283040-11	2008	In this study, lycopene, in dietary concentrations, reversed DHT effects of 6S cells on NPE cell death, decreased 6S cell IGF-I production by reducing AR and beta-catenin nuclear localization and inhibited IGF-I-stimulated NPE and PREC growth, perhaps by attenuating IGF-I"s effects on serine phosphorylation of Akt and GSK3beta and tyrosine phosphorylation of GSK3.	Lycopene	15-23	insulin like growth factor 1	Homo sapiens	206-211
18283040-11	2008	In this study, lycopene, in dietary concentrations, reversed DHT effects of 6S cells on NPE cell death, decreased 6S cell IGF-I production by reducing AR and beta-catenin nuclear localization and inhibited IGF-I-stimulated NPE and PREC growth, perhaps by attenuating IGF-I"s effects on serine phosphorylation of Akt and GSK3beta and tyrosine phosphorylation of GSK3.	Lycopene	15-23	insulin like growth factor 1	Homo sapiens	206-211
18283040-11	2008	In this study, lycopene, in dietary concentrations, reversed DHT effects of 6S cells on NPE cell death, decreased 6S cell IGF-I production by reducing AR and beta-catenin nuclear localization and inhibited IGF-I-stimulated NPE and PREC growth, perhaps by attenuating IGF-I"s effects on serine phosphorylation of Akt and GSK3beta and tyrosine phosphorylation of GSK3.	Lycopene	15-23	AKT serine/threonine kinase 1	Homo sapiens	312-315
18283040-11	2008	In this study, lycopene, in dietary concentrations, reversed DHT effects of 6S cells on NPE cell death, decreased 6S cell IGF-I production by reducing AR and beta-catenin nuclear localization and inhibited IGF-I-stimulated NPE and PREC growth, perhaps by attenuating IGF-I"s effects on serine phosphorylation of Akt and GSK3beta and tyrosine phosphorylation of GSK3.	Lycopene	15-23	glycogen synthase kinase 3 beta	Homo sapiens	320-328
18287363-4	2008	Plasma levels of matrix metalloproteinase (MMP)-2 and vascular endothelial growth factor (VEGF) increased gradually in tumor-injected mice (tumor controls) following tumor injection but were markedly lowered by lycopene or beta-carotene supplementation.	Lycopene	211-219	matrix metallopeptidase 2	Mus musculus	17-49
18287363-4	2008	Plasma levels of matrix metalloproteinase (MMP)-2 and vascular endothelial growth factor (VEGF) increased gradually in tumor-injected mice (tumor controls) following tumor injection but were markedly lowered by lycopene or beta-carotene supplementation.	Lycopene	211-219	vascular endothelial growth factor A	Mus musculus	54-88
18287363-4	2008	Plasma levels of matrix metalloproteinase (MMP)-2 and vascular endothelial growth factor (VEGF) increased gradually in tumor-injected mice (tumor controls) following tumor injection but were markedly lowered by lycopene or beta-carotene supplementation.	Lycopene	211-219	vascular endothelial growth factor A	Mus musculus	90-94
18287363-7	2008	High-lycopene supplementation also decreased the positive rate of proliferating cellular nuclear antigen (PCNA), the level of VEGF, and protein expressions of PCNA, MMP-9, and VEGF in lung tissues.	Lycopene	5-13	proliferating cell nuclear antigen	Homo sapiens	66-104
18287363-7	2008	High-lycopene supplementation also decreased the positive rate of proliferating cellular nuclear antigen (PCNA), the level of VEGF, and protein expressions of PCNA, MMP-9, and VEGF in lung tissues.	Lycopene	5-13	proliferating cell nuclear antigen	Homo sapiens	106-110
18287363-7	2008	High-lycopene supplementation also decreased the positive rate of proliferating cellular nuclear antigen (PCNA), the level of VEGF, and protein expressions of PCNA, MMP-9, and VEGF in lung tissues.	Lycopene	5-13	vascular endothelial growth factor A	Homo sapiens	126-130
18285342-6	2008	Additionally the Arabidopsis, maize, and tomato CCD1 enzymes all cleaved lycopene to generate 6-methyl-5-hepten-2-one.	Lycopene	73-81	white cap1	Zea mays	48-52
18287363-7	2008	High-lycopene supplementation also decreased the positive rate of proliferating cellular nuclear antigen (PCNA), the level of VEGF, and protein expressions of PCNA, MMP-9, and VEGF in lung tissues.	Lycopene	5-13	proliferating cell nuclear antigen	Homo sapiens	159-163
18287363-7	2008	High-lycopene supplementation also decreased the positive rate of proliferating cellular nuclear antigen (PCNA), the level of VEGF, and protein expressions of PCNA, MMP-9, and VEGF in lung tissues.	Lycopene	5-13	matrix metallopeptidase 9	Homo sapiens	165-170
18287363-7	2008	High-lycopene supplementation also decreased the positive rate of proliferating cellular nuclear antigen (PCNA), the level of VEGF, and protein expressions of PCNA, MMP-9, and VEGF in lung tissues.	Lycopene	5-13	vascular endothelial growth factor A	Homo sapiens	176-180
18287363-8	2008	However, high-lycopene increased the protein expression of nm23-H1 (an antimetastatic gene) by 133% (P &lt; 0.001).	Lycopene	14-22	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	59-66
18167141-8	2008	Quantitative real time PCR analysis showed that Psy2 transcript was present in all tested plant tissues, whereas Psy1 transcript could be detected in chromoplast-containing tissues, particularly in fruit where it activates and boosts lycopene accumulation.	Lycopene	234-242	phytoene synthase 1, chloroplastic	Solanum lycopersicum	113-117
18167141-2	2008	Its colour is due to the high content of lycopene whose synthesis is activated by the phytoene synthase 1 (PSY1) enzyme, encoded by Psy1 which is distinct from Psy2.	Lycopene	41-49	phytoene synthase 1, chloroplastic	Solanum lycopersicum	132-136
19083398-7	2008	These findings suggest that the suppression of oxidative stress, the reduction of plasma TNF-alpha and NO levels, and the down-regulation of TNF-alpha in lungs contribute to the alleviation of PF in rats administered lycopene.	Lycopene	217-225	tumor necrosis factor	Rattus norvegicus	89-98
19083398-7	2008	These findings suggest that the suppression of oxidative stress, the reduction of plasma TNF-alpha and NO levels, and the down-regulation of TNF-alpha in lungs contribute to the alleviation of PF in rats administered lycopene.	Lycopene	217-225	tumor necrosis factor	Rattus norvegicus	141-150
18156403-7	2008	The 6-mo lycopene supplementation decreased PSA levels in men (P &lt; 0.05), whereas there was no change in the placebo group.	Lycopene	9-17	kallikrein related peptidase 3	Homo sapiens	44-47
18389438-6	2008	Lycopene induced a dose-dependent increase in IL1beta, and TNFalpha production and a decrease in IL-2, IL-10 and IFNgamma secretion, whereas that of IL-6 and IL-1ra was not affected.	Lycopene	0-8	interleukin 1 beta	Homo sapiens	46-53
18389438-6	2008	Lycopene induced a dose-dependent increase in IL1beta, and TNFalpha production and a decrease in IL-2, IL-10 and IFNgamma secretion, whereas that of IL-6 and IL-1ra was not affected.	Lycopene	0-8	tumor necrosis factor	Homo sapiens	59-67
18389438-6	2008	Lycopene induced a dose-dependent increase in IL1beta, and TNFalpha production and a decrease in IL-2, IL-10 and IFNgamma secretion, whereas that of IL-6 and IL-1ra was not affected.	Lycopene	0-8	interleukin 2	Homo sapiens	97-101
18389438-6	2008	Lycopene induced a dose-dependent increase in IL1beta, and TNFalpha production and a decrease in IL-2, IL-10 and IFNgamma secretion, whereas that of IL-6 and IL-1ra was not affected.	Lycopene	0-8	interleukin 10	Homo sapiens	103-108
18389438-6	2008	Lycopene induced a dose-dependent increase in IL1beta, and TNFalpha production and a decrease in IL-2, IL-10 and IFNgamma secretion, whereas that of IL-6 and IL-1ra was not affected.	Lycopene	0-8	interferon gamma	Homo sapiens	113-121
18936536-9	2008	CONCLUSIONS: Low plasma concentrations of antioxidant vitamins (A, E, beta-carotene) and lycopene were associated with early carotid atherosclerotic lesions as measured by CIMT.	Lycopene	89-97	CIMT	Homo sapiens	172-176
18181168-6	2008	But, lycopene (2 microM, once per week for 2 weeks) did induce demethylation of RARbeta2 and the HIN-1 genes in the noncancer MCF10A fibrocystic breast cells.	Lycopene	5-13	OTU deubiquitinase 4	Homo sapiens	97-102
17950366-7	2007	PDGF-BB-induced phosphorylation of PDGF receptor beta (PDGFR-beta), extracellular signal-regulated kinase 1/2 (ERK1/2), p38, and c-Jun N-terminal kinase (JNK) was attenuated by lycopene in a concentration-dependent manner, whereas the total expression of each protein was not affected.	Lycopene	177-185	mitogen-activated protein kinase 8	Homo sapiens	129-152
17959141-3	2007	The aim of this study was to compare the effects of red tomato, yellow tomato (devoid of lycopene) and lycopene on Connexin43 (Cx43) expression, a protein regulating cell growth, on a prostate cancer cell line expressing the androgen receptor.	Lycopene	103-111	gap junction protein, alpha 1	Rattus norvegicus	115-125
17911344-7	2007	Lycopene also reduced the relative abundance of mRNA transcripts for scavenger receptor A (SR-A) in THP-1 macrophages treated with aggLDL.	Lycopene	0-8	macrophage scavenger receptor 1	Homo sapiens	69-89
17911344-7	2007	Lycopene also reduced the relative abundance of mRNA transcripts for scavenger receptor A (SR-A) in THP-1 macrophages treated with aggLDL.	Lycopene	0-8	macrophage scavenger receptor 1	Homo sapiens	91-95
17911344-7	2007	Lycopene also reduced the relative abundance of mRNA transcripts for scavenger receptor A (SR-A) in THP-1 macrophages treated with aggLDL.	Lycopene	0-8	GLI family zinc finger 2	Homo sapiens	100-105
17911344-8	2007	These findings suggest that lycopene may reduce macrophage foam cell formation induced by modified LDL by decreasing lipid synthesis and downregulating the activity and expression of SR-A.	Lycopene	28-36	macrophage scavenger receptor 1	Homo sapiens	183-187
17911344-9	2007	However, these effects are accompanied by impaired secretion of the anti-inflammatory cytokine IL-10, suggesting that lycopene may also exert a concomitant proinflammatory effect.	Lycopene	118-126	interleukin 10	Homo sapiens	95-100
18444168-2	2008	We conducted a randomized, placebo-controlled, double-blind, crossover trial to evaluate whether tomato-derived lycopene supplementation (30 mg/day for 2 mo) decreases serum levels of total IGF-I in premenopausal women with 1) a history of breast cancer (n=24) or 2) a high familial breast cancer risk (n=36).	Lycopene	112-120	insulin like growth factor 1	Homo sapiens	190-195
17911344-6	2007	In addition, lycopene inhibited IL-10 secretion by up to 74% regardless of the presence of nLDL or aggLDL but did not affect IL-1beta or TNF-alpha release.	Lycopene	13-21	interleukin 10	Homo sapiens	32-37
17991659-0	2007	Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer.	Lycopene	0-8	insulin like growth factor binding protein 1	Homo sapiens	46-97
17991659-2	2007	Lycopene intake is inversely associated with cancer risk, and experimental studies have shown that it may affect the IGF system, possibly through an effect on IGF-binding proteins (IGFBPs).	Lycopene	0-8	insulin like growth factor binding protein 1	Homo sapiens	181-187
17991659-3	2007	OBJECTIVE: The objective of our study was to investigate the effect of an 8-wk supplementation with tomato-derived lycopene (30 mg/d) on serum concentrations of total IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3.	Lycopene	115-123	insulin like growth factor 1	Homo sapiens	167-172
17991659-3	2007	OBJECTIVE: The objective of our study was to investigate the effect of an 8-wk supplementation with tomato-derived lycopene (30 mg/d) on serum concentrations of total IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3.	Lycopene	115-123	insulin like growth factor binding protein 1	Homo sapiens	182-189
17991659-3	2007	OBJECTIVE: The objective of our study was to investigate the effect of an 8-wk supplementation with tomato-derived lycopene (30 mg/d) on serum concentrations of total IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3.	Lycopene	115-123	insulin like growth factor binding protein 2	Homo sapiens	191-198
17991659-3	2007	OBJECTIVE: The objective of our study was to investigate the effect of an 8-wk supplementation with tomato-derived lycopene (30 mg/d) on serum concentrations of total IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3.	Lycopene	115-123	insulin like growth factor binding protein 3	Homo sapiens	204-211
17991659-5	2007	RESULTS: Lycopene supplementation significantly (P = 0.01) increased serum IGFBP-1 concentrations in women (median relative difference between serum IGFBP-1 concentrations after lycopene supplementation and after placebo, 21.7%).	Lycopene	9-17	insulin like growth factor binding protein 1	Homo sapiens	75-82
17991659-5	2007	RESULTS: Lycopene supplementation significantly (P = 0.01) increased serum IGFBP-1 concentrations in women (median relative difference between serum IGFBP-1 concentrations after lycopene supplementation and after placebo, 21.7%).	Lycopene	9-17	insulin like growth factor binding protein 1	Homo sapiens	149-156
17991659-6	2007	Serum IGFBP-2 concentrations were higher in both men and women after lycopene supplementation than after placebo, but to a lesser extent (mean relative difference 8.2%; 95% CI: 0.7%, 15.6% in men and 7.8%; 95% CI: -5.0%, 20.6% in women).	Lycopene	69-77	insulin like growth factor binding protein 2	Homo sapiens	6-13
17991659-8	2007	CONCLUSIONS: This is the first study known to show that lycopene supplementation may increase circulating IGFBP-1 and IGFBP-2 concentrations.	Lycopene	56-64	insulin like growth factor binding protein 1	Homo sapiens	106-113
17991659-8	2007	CONCLUSIONS: This is the first study known to show that lycopene supplementation may increase circulating IGFBP-1 and IGFBP-2 concentrations.	Lycopene	56-64	insulin like growth factor binding protein 2	Homo sapiens	118-125
17299493-0	2007	Effect of lycopene supplementation on insulin-like growth factor-1 and insulin-like growth factor binding protein-3: a double-blind, placebo-controlled trial.	Lycopene	10-18	insulin like growth factor 1	Homo sapiens	38-115
17299493-1	2007	OBJECTIVE: Studies have suggested a link between lycopene and insulin-like growth factor-1 (IGF-1).	Lycopene	49-57	insulin like growth factor 1	Homo sapiens	62-90
17299493-1	2007	OBJECTIVE: Studies have suggested a link between lycopene and insulin-like growth factor-1 (IGF-1).	Lycopene	49-57	insulin like growth factor 1	Homo sapiens	92-97
17299493-2	2007	The aim of this study was to test the effect of lycopene supplementation on IGF-1 and binding protein-3 (IGFBP-3) status in healthy male volunteers.	Lycopene	48-56	insulin like growth factor binding protein 3	Homo sapiens	76-103
17299493-2	2007	The aim of this study was to test the effect of lycopene supplementation on IGF-1 and binding protein-3 (IGFBP-3) status in healthy male volunteers.	Lycopene	48-56	insulin like growth factor binding protein 3	Homo sapiens	105-112
17299493-9	2007	Change in lycopene concentration was associated with the change in IGFBP-3 in the intervention group (r=0.78; P=0.008; n=10).	Lycopene	10-18	insulin like growth factor binding protein 3	Homo sapiens	67-74
17299493-11	2007	However, the association between change in lycopene concentration and change in IGFBP-3 in the intervention group suggests a potential effect of lycopene supplementation on IGFBP-3.	Lycopene	43-51	insulin like growth factor binding protein 3	Homo sapiens	80-87
17299493-11	2007	However, the association between change in lycopene concentration and change in IGFBP-3 in the intervention group suggests a potential effect of lycopene supplementation on IGFBP-3.	Lycopene	43-51	insulin like growth factor binding protein 3	Homo sapiens	173-180
17299493-11	2007	However, the association between change in lycopene concentration and change in IGFBP-3 in the intervention group suggests a potential effect of lycopene supplementation on IGFBP-3.	Lycopene	145-153	insulin like growth factor binding protein 3	Homo sapiens	80-87
17299493-11	2007	However, the association between change in lycopene concentration and change in IGFBP-3 in the intervention group suggests a potential effect of lycopene supplementation on IGFBP-3.	Lycopene	145-153	insulin like growth factor binding protein 3	Homo sapiens	173-180
17438348-0	2007	Immunohistochemical expression of RARalpha, RARbeta, and Cx43 in breast tumor cell lines after treatment with lycopene and correlation with RT-QPCR.	Lycopene	110-118	retinoic acid receptor alpha	Homo sapiens	34-42
17846065-2	2007	Mutants (delta-4, -8, -12 and -16) produced lycopene-derived red colour, but mutants (delta-17, -18, -19, -20, -23, -57 and -70) did not.	Lycopene	44-52	delta like canonical Notch ligand 4	Rattus norvegicus	9-33
17438348-0	2007	Immunohistochemical expression of RARalpha, RARbeta, and Cx43 in breast tumor cell lines after treatment with lycopene and correlation with RT-QPCR.	Lycopene	110-118	gap junction protein alpha 1	Homo sapiens	57-61
18095570-7	2007	CONCLUSION: Lycopene can induce apoptosis of PC-3, change the cell cycle distribution and downregulate the expression of cyclin D1 and bcl-2 and upregulate the expression of bax and then restrain cell proliferation.	Lycopene	12-20	BCL2 associated X, apoptosis regulator	Homo sapiens	174-177
17420169-2	2007	We recently showed that lycopene can be converted to apo-10"-lycopenoids [Hu et al.	Lycopene	24-32	anterior polar opacity	Mus musculus	53-56
17477920-0	2007	Lycopene, quercetin and tyrosol prevent macrophage activation induced by gliadin and IFN-gamma.	Lycopene	0-8	interferon gamma	Homo sapiens	85-94
17477920-2	2007	We have studied the effect of the lycopene, quercetin and tyrosol natural antioxidants on the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene expression in RAW 264.7 macrophages stimulated by gliadin in association with IFN-gamma.	Lycopene	34-42	nitric oxide synthase 2	Homo sapiens	94-125
17477920-2	2007	We have studied the effect of the lycopene, quercetin and tyrosol natural antioxidants on the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene expression in RAW 264.7 macrophages stimulated by gliadin in association with IFN-gamma.	Lycopene	34-42	nitric oxide synthase 2	Homo sapiens	127-131
17477920-2	2007	We have studied the effect of the lycopene, quercetin and tyrosol natural antioxidants on the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) gene expression in RAW 264.7 macrophages stimulated by gliadin in association with IFN-gamma.	Lycopene	34-42	prostaglandin-endoperoxide synthase 2	Homo sapiens	137-153
17477920-3	2007	The IFN-gamma plus gliadin combination treatment was capable of enhancing iNOS and COX-2 gene expression and nuclear factor-kappaB (NF-kappaB), interferon regulatory factor-1 (IRF-1) and signal transducer and activator of transcription-1alpha (STAT-1alpha) activation induced by reactive oxygen species generation at 24 h. Lycopene, quercetin and tyrosol inhibited all these effects.	Lycopene	323-331	interferon gamma	Homo sapiens	4-13
18095570-0	2007	[Effect of lycopene on proliferation and cell cycle of hormone refractory prostate cancer PC-3 cell line].	Lycopene	11-19	proprotein convertase subtilisin/kexin type 1	Homo sapiens	90-94
18095570-1	2007	OBJECTIVE: To investigate the effects of lycopene on proliferation of human prostate cancer cell line PC-3 and explore its effecting mechanism.	Lycopene	41-49	proprotein convertase subtilisin/kexin type 1	Homo sapiens	102-106
18095570-5	2007	RESULTS: The growth and DNA synthesis of PC-3 cell were inhibited with the lycopene concentration increased, and lycopene also could change the cell cycle distribution, i. e. increasing the proportion of G0/G1 phase and descending the proportion of S and G2/M phase, and induce the apoptosis.	Lycopene	75-83	proprotein convertase subtilisin/kexin type 1	Homo sapiens	41-45
18095570-7	2007	CONCLUSION: Lycopene can induce apoptosis of PC-3, change the cell cycle distribution and downregulate the expression of cyclin D1 and bcl-2 and upregulate the expression of bax and then restrain cell proliferation.	Lycopene	12-20	proprotein convertase subtilisin/kexin type 1	Homo sapiens	45-49
18095570-7	2007	CONCLUSION: Lycopene can induce apoptosis of PC-3, change the cell cycle distribution and downregulate the expression of cyclin D1 and bcl-2 and upregulate the expression of bax and then restrain cell proliferation.	Lycopene	12-20	cyclin D1	Homo sapiens	121-130
18095570-7	2007	CONCLUSION: Lycopene can induce apoptosis of PC-3, change the cell cycle distribution and downregulate the expression of cyclin D1 and bcl-2 and upregulate the expression of bax and then restrain cell proliferation.	Lycopene	12-20	BCL2 apoptosis regulator	Homo sapiens	135-140
17554202-10	2007	The plasma concentration of insulin-like growth factor-I decreased significantly by about 25% after tomato lycopene extract supplementation as compared with the placebo-treated group (P&lt;0.05).	Lycopene	107-115	insulin like growth factor 1	Homo sapiens	28-56
17554202-12	2007	Given that high plasma levels of insulin-like growth factor-I have been suggested as a risk factor for various types of cancer including colon cancer, the results support our suggestion that tomato lycopene extract has a role in the prevention of colon and possibly other types of cancer.	Lycopene	198-206	insulin like growth factor 1	Homo sapiens	33-61
17420169-11	2007	These observations demonstrate that apo-10"-lycopenoic acid is a biological active metabolite of lycopene and suggest that apo-10"-lycopenoic acid is a potential chemopreventive agent against lung tumorigenesis.	Lycopene	97-105	anterior polar opacity	Mus musculus	36-39
17049831-0	2007	Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1.	Lycopene	0-8	matrix metallopeptidase 9	Homo sapiens	18-44
17049831-0	2007	Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1.	Lycopene	0-8	nuclear factor kappa B subunit 1	Homo sapiens	99-121
17049831-0	2007	Lycopene inhibits matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear factor-kappa B and stimulatory protein-1.	Lycopene	0-8	Sp1 transcription factor	Homo sapiens	126-147
17049831-3	2007	Here, we used SK-Hep-1 cells (from a human hepatoma) to test whether lycopene exerts its anti-invasion activity via down-regulation of the expression of matrix metalloproteinase (MMP)-9, an important enzyme in the degradation of basement membrane in cancer invasion.	Lycopene	69-77	matrix metallopeptidase 9	Homo sapiens	153-185
17049831-6	2007	We showed that lycopene (1-10 microM) significantly inhibited SK-Hep-1 invasion (P&lt;.05) and that this effect correlated with the inhibition of MMP-9 at the levels of enzyme activity (r(2)=.94, P&lt;.001), protein expression (r(2)=.80, P=.007) and mRNA expression (r(2)=.94, P&lt;.001).	Lycopene	15-23	matrix metallopeptidase 9	Homo sapiens	146-151
17049831-7	2007	Lycopene also significantly inhibited the binding abilities of NF-kappaB and Sp1 and decreased, to some extent, the expression of insulin-like growth factor-1 receptor (IGF-1R) and the intracellular level of reactive oxygen species (P&lt;.05).	Lycopene	0-8	nuclear factor kappa B subunit 1	Homo sapiens	63-72
17049831-7	2007	Lycopene also significantly inhibited the binding abilities of NF-kappaB and Sp1 and decreased, to some extent, the expression of insulin-like growth factor-1 receptor (IGF-1R) and the intracellular level of reactive oxygen species (P&lt;.05).	Lycopene	0-8	insulin like growth factor 1 receptor	Homo sapiens	130-167
17049831-7	2007	Lycopene also significantly inhibited the binding abilities of NF-kappaB and Sp1 and decreased, to some extent, the expression of insulin-like growth factor-1 receptor (IGF-1R) and the intracellular level of reactive oxygen species (P&lt;.05).	Lycopene	0-8	insulin like growth factor 1 receptor	Homo sapiens	169-175
17049831-8	2007	The antioxidant effect of lycopene appeared to play a minor role in its inhibition of MMP-9 and invasion activity of SK-Hep-1 cells because coincubation of cells with lycopene plus hydrogen peroxide abolished the antioxidant effect but did not significantly affect the anti-invasion ability of lycopene.	Lycopene	26-34	matrix metallopeptidase 9	Homo sapiens	86-91
17049831-9	2007	Thus, lycopene decreases the invasive ability of SK-Hep-1 cells by inhibiting MMP-9 expression and suppressing the binding activity of NF-kappaB and Sp1.	Lycopene	6-14	matrix metallopeptidase 9	Homo sapiens	78-83
17049831-9	2007	Thus, lycopene decreases the invasive ability of SK-Hep-1 cells by inhibiting MMP-9 expression and suppressing the binding activity of NF-kappaB and Sp1.	Lycopene	6-14	nuclear factor kappa B subunit 1	Homo sapiens	135-144
17049831-10	2007	These effects of lycopene may be related to the down-regulation of IGF-1R, while the antioxidant activity of lycopene appears to play a minor role.	Lycopene	17-25	insulin like growth factor 1 receptor	Homo sapiens	67-73
17328921-6	2007	These findings demonstrate that the incorporation of lycopene into CRLPs decreases their uptake by HepG2 cells and suggest that this effect is due to differential interaction with the LDL receptor and the LRP-receptor-mediated pathways, and may also involve binding of the particles to HSPG.	Lycopene	53-61	low density lipoprotein receptor	Homo sapiens	184-196
17449016-5	2007	We found that preincubation of PDGF-BB with lycopene resulted in a marked inhibition on PDGF-BB-induced PDGF receptor-beta (PDGFR-beta), PLCgamma, and ERK1/2 phosphorylation in rat A10 SMCs and primary cultured aortic SMCs.	Lycopene	44-52	platelet derived growth factor receptor beta	Rattus norvegicus	124-134
17449016-5	2007	We found that preincubation of PDGF-BB with lycopene resulted in a marked inhibition on PDGF-BB-induced PDGF receptor-beta (PDGFR-beta), PLCgamma, and ERK1/2 phosphorylation in rat A10 SMCs and primary cultured aortic SMCs.	Lycopene	44-52	mitogen activated protein kinase 3	Rattus norvegicus	151-157
17219202-0	2007	Effect of lycopene on insulin-like growth factor-I, IGF binding protein-3 and IGF type-I receptor in prostate cancer cells.	Lycopene	10-18	insulin like growth factor binding protein 3	Homo sapiens	52-73
17219202-10	2007	Lycopene, at a dose of 40 microM, significantly increased the level of IGFBP-3.	Lycopene	0-8	insulin like growth factor binding protein 3	Homo sapiens	71-78
17219202-11	2007	Lycopene-induced apoptosis was confirmed by annexin V and PI binding.	Lycopene	0-8	annexin A5	Homo sapiens	44-53
17219202-13	2007	There was a significant decrease in the IGF-IR expression after the cells were treated with lycopene and IGF-I.	Lycopene	92-100	insulin like growth factor 1 receptor	Homo sapiens	40-46
17219202-13	2007	There was a significant decrease in the IGF-IR expression after the cells were treated with lycopene and IGF-I.	Lycopene	92-100	insulin like growth factor 1	Homo sapiens	40-45
17328921-6	2007	These findings demonstrate that the incorporation of lycopene into CRLPs decreases their uptake by HepG2 cells and suggest that this effect is due to differential interaction with the LDL receptor and the LRP-receptor-mediated pathways, and may also involve binding of the particles to HSPG.	Lycopene	53-61	LDL receptor related protein 1	Homo sapiens	205-208
17337101-6	2007	Immunoblot screening indicated that lycopene"s antiproliferative effects are likely achieved through a block in G1/S transition mediated by decreased levels of cyclins D1 and E and cyclin dependent kinase 4 and suppressed Retinoblastoma phosphorylation.	Lycopene	36-44	cyclin D1	Homo sapiens	160-176
17337101-6	2007	Immunoblot screening indicated that lycopene"s antiproliferative effects are likely achieved through a block in G1/S transition mediated by decreased levels of cyclins D1 and E and cyclin dependent kinase 4 and suppressed Retinoblastoma phosphorylation.	Lycopene	36-44	cyclin dependent kinase 4	Homo sapiens	181-206
17927495-4	2007	In this Phase II clinical trial, we investigated the efficacy of lycopene alone or in combination with soy isoflavones on serum PSA levels in men with prostate cancer.	Lycopene	65-73	kallikrein related peptidase 3	Homo sapiens	128-131
17896580-1	2007	OBJECTIVE: The aim of this study was to assess the relationship between lycopene and insulin-like growth factor-1 levels in a healthy male population.	Lycopene	72-80	insulin like growth factor 1	Homo sapiens	85-113
17896580-2	2007	DESIGN: Insulin-like growth factor-1 status was assessed in healthy men aged 30-49 years (n = 104) with either high or low lycopene concentrations.	Lycopene	123-131	insulin like growth factor 1	Homo sapiens	8-36
17995901-0	2007	Lycopene inhibits LPS-induced proinflammatory mediator inducible nitric oxide synthase in mouse macrophage cells.	Lycopene	0-8	toll-like receptor 4	Mus musculus	18-21
17995901-0	2007	Lycopene inhibits LPS-induced proinflammatory mediator inducible nitric oxide synthase in mouse macrophage cells.	Lycopene	0-8	nitric oxide synthase 2, inducible	Mus musculus	55-86
17995901-3	2007	Treatment with lycopene (10 microM) inhibited lipopolysaccharide (LPS)-stimulated nitric oxide (NO) production (40% compared with the control).	Lycopene	15-23	toll-like receptor 4	Mus musculus	66-69
17995901-4	2007	Western blotting and reverse transcription-polymerase chain reaction (RT-PCR) analysis showed that lycopene treatment decreased LPS-induced inducible nitric oxide synthase (iNOS) protein and mRNA expression in RAW 264.7 cells, respectively.	Lycopene	99-107	toll-like receptor 4	Mus musculus	128-131
17995901-4	2007	Western blotting and reverse transcription-polymerase chain reaction (RT-PCR) analysis showed that lycopene treatment decreased LPS-induced inducible nitric oxide synthase (iNOS) protein and mRNA expression in RAW 264.7 cells, respectively.	Lycopene	99-107	nitric oxide synthase 2, inducible	Mus musculus	140-171
17995901-4	2007	Western blotting and reverse transcription-polymerase chain reaction (RT-PCR) analysis showed that lycopene treatment decreased LPS-induced inducible nitric oxide synthase (iNOS) protein and mRNA expression in RAW 264.7 cells, respectively.	Lycopene	99-107	nitric oxide synthase 2, inducible	Mus musculus	173-177
17995901-5	2007	These results suggest that lycopene has anti-inflammatory activity by inhibiting iNOS proteins and mRNA expressions in mouse macrophage cell lines.	Lycopene	27-35	nitric oxide synthase 2, inducible	Mus musculus	81-85
17571945-1	2007	This unblinded, randomized, Phase I clinical trial was conducted to determine whether lycopene supplementation lowered serum prostate specific antigen (PSA), surrogate endpoint for prostate cancer initiation or progression, in men with elevated prostate cancer risk.	Lycopene	86-94	kallikrein related peptidase 3	Homo sapiens	125-150
17571945-1	2007	This unblinded, randomized, Phase I clinical trial was conducted to determine whether lycopene supplementation lowered serum prostate specific antigen (PSA), surrogate endpoint for prostate cancer initiation or progression, in men with elevated prostate cancer risk.	Lycopene	86-94	kallikrein related peptidase 3	Homo sapiens	152-155
17571945-9	2007	We conclude that the PSA lowering response to antioxidant supplementation observed in previous 3-wk studies in men awaiting prostatectomy may have been a transient response, perhaps not specific to lycopene.	Lycopene	198-206	kallikrein related peptidase 3	Homo sapiens	21-24
17140762-7	2007	The induction of GJIC by lycopene was confirmed by an increased expression of connexin 43.	Lycopene	25-33	gap junction protein alpha 1	Homo sapiens	78-89
17304333-17	2007	CONCLUSION: Lycopene might attenuate lipopolysaccharide-induced impairment of lungs and improve ALI prognosis by increasing the phagocytic function of PAMs significantly and restraining the secretion of TNF-alpha and IL-8.	Lycopene	12-20	tumor necrosis factor	Rattus norvegicus	203-212
17640163-5	2007	Results demonstrated that both lycopene, in an alpha -cyclodextrin water soluble carrier, and lutein inhibited malignant AT3 cells in a concentration and time-dependent manner.	Lycopene	31-39	angiotensin II receptor, type 1b	Rattus norvegicus	121-124
17927495-11	2007	The data suggest that lycopene and soy isoflavones have activity in prostate cancer patients with PSA relapse disease and may delay progression of both hormone-refractory and hormone-sensitive prostate cancer.	Lycopene	22-30	kallikrein related peptidase 3	Homo sapiens	98-101
16835502-0	2006	Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways.	Lycopene	45-53	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	151-167
17092735-6	2006	The hp-1 mutant also had the highest chlorophyll and total carotenoid concentrations, comprised mostly of lycopene in red ripe fruit; whereas, beta-carotene comprised 90% of the carotenoids in B.	Lycopene	106-114	DNA damage-binding protein 1	Solanum lycopersicum	4-8
16906286-8	2006	Dietary ingestion of 50 g of tomato paste per day for 10 weeks significantly reduced mean plasma PSA levels in patients with benign prostate hyperplasia, probably as a result of the high amount of lycopene in tomato paste.	Lycopene	197-205	kallikrein related peptidase 3	Homo sapiens	97-100
16565789-0	2006	Lycopene inhibition of IGF-induced cancer cell growth depends on the level of cyclin D1.	Lycopene	0-8	cyclin D1	Homo sapiens	78-87
16565789-6	2006	We have previously demonstrated that slowdown of serum-stimulated cell cycle progression from G1 to S phase by lycopene correlates with reduction in cyclin D1 levels, suggesting that the expression of this protein is a main target for lycopene"s action.	Lycopene	235-243	cyclin D1	Homo sapiens	149-158
16565789-7	2006	AIM OF THE STUDY: To determine whether the reported reduction in cyclin D1 level is the key mechanism for lycopene and atRA inhibitory action on IGF-I-induced cell cycle progression.	Lycopene	106-114	cyclin D1	Homo sapiens	65-74
16565789-9	2006	Cell treatment with lycopene and atRA inhibited IGF-I-stimulated cell cycle progression from G1 to S phase and decreased retinoblastoma protein (pRb) phosphorylation.	Lycopene	20-28	insulin like growth factor 1	Homo sapiens	48-53
16565789-9	2006	Cell treatment with lycopene and atRA inhibited IGF-I-stimulated cell cycle progression from G1 to S phase and decreased retinoblastoma protein (pRb) phosphorylation.	Lycopene	20-28	RB transcriptional corepressor 1	Homo sapiens	145-148
16565789-12	2006	Our results showed that ectopic expression of cyclin D1 can overcome cell cycle inhibition caused by lycopene and atRA.	Lycopene	101-109	cyclin D1	Homo sapiens	46-55
17056806-5	2006	Some changes in prostatic and testicular steroidogenic enzyme mRNA expression were found; in particular, prostate 17 beta-hydroxysteroid dehydrogenase 4 mRNA expression in castrated rats fed lycopene or tomato powder was 1.7-fold that of the sham-operated, control-fed group.	Lycopene	191-199	hydroxysteroid (17-beta) dehydrogenase 4	Rattus norvegicus	114-152
17121935-5	2006	Levels of prostate-specific antigen secreted into the incubation medium by LNCaP cells were reduced 55% as a result of lycopene treatment at 1.48 micromol/L.	Lycopene	119-127	kallikrein related peptidase 3	Homo sapiens	10-35
17121935-6	2006	The binding of lycopene to the ligand-binding domain of the human androgen receptor was carried out, but lycopene was not found to be a ligand for this receptor.	Lycopene	15-23	androgen receptor	Homo sapiens	66-83
16837203-12	2006	Lycopene and lycophyll were predicted to bind with high affinity in the superficial cleft at the interface of the beta-barrel and the catalytic domain of 5-LOX (the "cleavage site").	Lycopene	0-8	arachidonate 5-lipoxygenase	Homo sapiens	154-159
16837203-14	2006	In addition, the two bioactive metabolites of lycopene were predicted to bind to the catalytic site with high affinity--therefore suggesting potential direct competitive inhibition of 5-LOX activity that should be shared by both lycopene and lycophyll after in vivo supplementation, particularly in the case of the dial metabolite.	Lycopene	46-54	arachidonate 5-lipoxygenase	Homo sapiens	184-189
16837203-14	2006	In addition, the two bioactive metabolites of lycopene were predicted to bind to the catalytic site with high affinity--therefore suggesting potential direct competitive inhibition of 5-LOX activity that should be shared by both lycopene and lycophyll after in vivo supplementation, particularly in the case of the dial metabolite.	Lycopene	229-237	arachidonate 5-lipoxygenase	Homo sapiens	184-189
16565789-13	2006	CONCLUSIONS: Our findings suggest that attenuation of cyclin Dl levels by lycopene and atRA is an important mechanism for the reduction of the mitogenic action of IGF-I.	Lycopene	74-82	insulin like growth factor 1	Homo sapiens	163-168
16835502-0	2006	Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways.	Lycopene	45-53	nitric oxide synthase 2	Rattus norvegicus	172-203
16672231-5	2006	The cleavage activity of ferret CMO2 was higher toward lycopene cis-isomers as compared with beta-carotene as substrate.	Lycopene	55-63	beta-carotene oxygenase 2	Mus musculus	32-36
16672231-7	2006	Furthermore, all-trans-lycopene supplementation in ferrets resulted in significant accumulation of cis-isomers of lycopene and the formation of apo-10"-lycopenol, as well as up-regulation of the CMO2 expression in lung tissues.	Lycopene	13-31	beta-carotene oxygenase 2	Mus musculus	195-199
16672231-3	2006	Here we provide information on the biochemical characterization of CMO2 of the ferret, a model for human carotenoid metabolism, in terms of the kinetic analysis of beta-carotene/lycopene cleavage into beta-apo-10"-carotenal/apo-10"-lycopenal in vitro and the formation of apo-10"-lycopenoids in ferrets in vivo.	Lycopene	178-186	beta-carotene oxygenase 2	Mus musculus	67-71
16672231-7	2006	Furthermore, all-trans-lycopene supplementation in ferrets resulted in significant accumulation of cis-isomers of lycopene and the formation of apo-10"-lycopenol, as well as up-regulation of the CMO2 expression in lung tissues.	Lycopene	23-31	beta-carotene oxygenase 2	Mus musculus	195-199
16672231-9	2006	Our finding of bioconversion of cis-isomers of lycopene into apo-10"-lycopenoids by CMO2 is significant because cis-isomers of lycopene are a predominant form of lycopene in mammalian tissues and apo-lycopenoids may have specific biological activities related to human health.	Lycopene	47-55	beta-carotene oxygenase 2	Mus musculus	84-88
16672231-9	2006	Our finding of bioconversion of cis-isomers of lycopene into apo-10"-lycopenoids by CMO2 is significant because cis-isomers of lycopene are a predominant form of lycopene in mammalian tissues and apo-lycopenoids may have specific biological activities related to human health.	Lycopene	127-135	beta-carotene oxygenase 2	Mus musculus	84-88
16672231-9	2006	Our finding of bioconversion of cis-isomers of lycopene into apo-10"-lycopenoids by CMO2 is significant because cis-isomers of lycopene are a predominant form of lycopene in mammalian tissues and apo-lycopenoids may have specific biological activities related to human health.	Lycopene	127-135	beta-carotene oxygenase 2	Mus musculus	84-88
16702320-0	2006	Apo-8"-lycopenal and apo-12"-lycopenal are metabolic products of lycopene in rat liver.	Lycopene	65-73	aminopeptidase O	Rattus norvegicus	0-3
16702320-0	2006	Apo-8"-lycopenal and apo-12"-lycopenal are metabolic products of lycopene in rat liver.	Lycopene	65-73	aminopeptidase O	Rattus norvegicus	21-24
16702320-8	2006	These data show that lycopene is cleaved in vivo by rats at different positions to produce apo-12"-lycopenal, and other unidentified metabolites in addition to apo-8"-lycopenal.	Lycopene	21-29	aminopeptidase O	Rattus norvegicus	91-94
16702320-8	2006	These data show that lycopene is cleaved in vivo by rats at different positions to produce apo-12"-lycopenal, and other unidentified metabolites in addition to apo-8"-lycopenal.	Lycopene	21-29	aminopeptidase O	Rattus norvegicus	160-163
16702320-9	2006	Apo-8"-lycopenal and the putative apo-12"-lycopenal are identified as lycopene metabolites in rat liver in vivo.	Lycopene	70-78	aminopeptidase O	Rattus norvegicus	0-3
16702320-9	2006	Apo-8"-lycopenal and the putative apo-12"-lycopenal are identified as lycopene metabolites in rat liver in vivo.	Lycopene	70-78	aminopeptidase O	Rattus norvegicus	34-37
16514180-5	2006	Lycopene decreased the gelatinolytic activities of both matrix metalloproteinase (MMP)-2 and MMP-9, which were secreted from the SK-Hep1 cells.	Lycopene	0-8	matrix metallopeptidase 2	Homo sapiens	56-88
16549453-0	2006	Dietary lycopene downregulates carotenoid 15,15"-monooxygenase and PPAR-gamma in selected rat tissues.	Lycopene	8-16	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	67-77
16549453-2	2006	The objectives of this study were to clone the rat CMO2 gene, determine whether feeding lycopene for different lengths of time (3-37 d) altered the expression of genes related to carotenoid cleavage [CMO1, CMO2 and peroxisomal proliferator-activated receptor gamma (PPAR-gamma)] or increased the activity of selected phase I and phase II detoxification enzymes in rat tissues.	Lycopene	88-96	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	215-264
16549453-2	2006	The objectives of this study were to clone the rat CMO2 gene, determine whether feeding lycopene for different lengths of time (3-37 d) altered the expression of genes related to carotenoid cleavage [CMO1, CMO2 and peroxisomal proliferator-activated receptor gamma (PPAR-gamma)] or increased the activity of selected phase I and phase II detoxification enzymes in rat tissues.	Lycopene	88-96	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	266-276
16549453-5	2006	CMO1 and PPAR-gamma expression were decreased in the kidney and adrenal with lycopene intake (P &lt; 0.05), whereas CMO2 expression was reduced only in the kidney.	Lycopene	77-85	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	9-19
16549453-7	2006	Lycopene intake decreased a PPAR-gamma target gene, fatty acid binding protein 3 (FABP3), in the kidney and adrenal (P &lt; 0.05).	Lycopene	0-8	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	28-38
16549453-7	2006	Lycopene intake decreased a PPAR-gamma target gene, fatty acid binding protein 3 (FABP3), in the kidney and adrenal (P &lt; 0.05).	Lycopene	0-8	fatty acid binding protein 3	Rattus norvegicus	52-80
16549453-7	2006	Lycopene intake decreased a PPAR-gamma target gene, fatty acid binding protein 3 (FABP3), in the kidney and adrenal (P &lt; 0.05).	Lycopene	0-8	fatty acid binding protein 3	Rattus norvegicus	82-87
16549453-8	2006	Thus, these data show that although the intake of 0.25 g lycopene/kg diet does not induce hepatic P450 detoxification enzymes, lycopene feeding alters CMO1, PPAR-gamma, and FABP3 mRNA expression in selected rat tissues with a moderate effect on kidney CMO2 expression.	Lycopene	127-135	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	157-167
16549453-8	2006	Thus, these data show that although the intake of 0.25 g lycopene/kg diet does not induce hepatic P450 detoxification enzymes, lycopene feeding alters CMO1, PPAR-gamma, and FABP3 mRNA expression in selected rat tissues with a moderate effect on kidney CMO2 expression.	Lycopene	127-135	fatty acid binding protein 3	Rattus norvegicus	173-178
16514180-5	2006	Lycopene decreased the gelatinolytic activities of both matrix metalloproteinase (MMP)-2 and MMP-9, which were secreted from the SK-Hep1 cells.	Lycopene	0-8	matrix metallopeptidase 9	Homo sapiens	93-98
16365067-12	2006	Lycopene prevented smoke-induced changes in p21(Waf1/Cip1), Bax-1, cleaved caspase 3, cyclin D1, and PCNA in a dose-dependent fashion.	Lycopene	0-8	G1/S-specific cyclin-D1	Mustela putorius furo	86-95
16365067-12	2006	Lycopene prevented smoke-induced changes in p21(Waf1/Cip1), Bax-1, cleaved caspase 3, cyclin D1, and PCNA in a dose-dependent fashion.	Lycopene	0-8	proliferating cell nuclear antigen	Mustela putorius furo	101-105
16301113-7	2005	RESULTS: Our results show that lycopene can delay or prevent HGPIN from developing into occult prostate cancer, and there exists an inverse relationship between lycopene and prostate-specific antigen.	Lycopene	161-169	kallikrein related peptidase 3	Homo sapiens	174-199
16125832-12	2005	On the other hand, administration of simultaneous lycopene to rats produced amelioration in MDA and GSH levels and GSH-Px and CAT activities when compared with gentamicin group.	Lycopene	50-58	catalase	Rattus norvegicus	126-129
16965236-0	2006	Lycopene intake and prostate cancer risk: effect modification by plasma antioxidants and the XRCC1 genotype.	Lycopene	0-8	X-ray repair cross complementing 1	Homo sapiens	93-98
16965236-2	2006	We hypothesize that an effect of lycopene may be modified by XRCC1 genotype and other antioxidants.	Lycopene	33-41	X-ray repair cross complementing 1	Homo sapiens	61-66
16965236-10	2006	Although limited by small sample size, these findings indicate that the association between lycopene and prostate cancer is complex and may be modified by other antioxidants and by XRCC1 genotype.	Lycopene	92-100	X-ray repair cross complementing 1	Homo sapiens	181-186
16983396-0	2006	Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study.	Lycopene	0-8	kallikrein related peptidase 3	Homo sapiens	130-155
16197586-0	2005	Lycopene supplementation attenuated xanthine oxidase and myeloperoxidase activities in skeletal muscle tissues of rats after exhaustive exercise.	Lycopene	0-8	myeloperoxidase	Rattus norvegicus	57-72
15549328-0	2005	Lycopene enhances UVA-induced DNA damage and expression of heme oxygenase-1 in cultured mouse embryo fibroblasts.	Lycopene	0-8	heme oxygenase 1	Mus musculus	59-75
16194683-6	2005	In addition, lycopene (6 and 12 micromol/L) significantly increased the formations of cyclic GMP and nitrate but not cyclic AMP in human platelets.	Lycopene	13-21	5'-nucleotidase, cytosolic II	Homo sapiens	93-96
15549328-3	2005	AIM OF THE STUDY: We examined whether lycopene inhibits ultraviolet A (UVA)-induced DNA damage and the expression of heme oxygenase-1 (HO-1).	Lycopene	38-46	heme oxygenase 1	Mus musculus	135-139
15549328-12	2005	In addition, lycopene enhanced UVA-induced HO-1 expression by ca.	Lycopene	13-21	heme oxygenase 1	Mus musculus	43-47
15549328-15	2005	When cells were incubated with lycopene that had been pre-irradiated with UVA without subjecting the cells to further UVA irradiation, cellular DNA damage and expression of HO-1 were markedly increased, and these effects of irradiated lycopene were concentration-dependent.	Lycopene	31-39	heme oxygenase 1	Mus musculus	173-177
15549328-15	2005	When cells were incubated with lycopene that had been pre-irradiated with UVA without subjecting the cells to further UVA irradiation, cellular DNA damage and expression of HO-1 were markedly increased, and these effects of irradiated lycopene were concentration-dependent.	Lycopene	235-243	heme oxygenase 1	Mus musculus	173-177
16030430-0	2005	Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis.	Lycopene	35-43	BCL2, apoptosis regulator	Rattus norvegicus	76-81
16140886-0	2005	Lycopene inhibits cell migration and invasion and upregulates Nm23-H1 in a highly invasive hepatocarcinoma, SK-Hep-1 cells.	Lycopene	0-8	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	62-69
16140886-4	2005	Here, we tested the possibility that lycopene may inhibit cancer cell metastasis by upregulating the expression of nm23-H1, a metastasis suppressor gene, in SK-Hep-1 cells, a highly invasive hepatoma cell line, and we determined migration and invasion activities and the expression of nm23-H1 protein and mRNA.	Lycopene	37-45	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	115-122
16140886-4	2005	Here, we tested the possibility that lycopene may inhibit cancer cell metastasis by upregulating the expression of nm23-H1, a metastasis suppressor gene, in SK-Hep-1 cells, a highly invasive hepatoma cell line, and we determined migration and invasion activities and the expression of nm23-H1 protein and mRNA.	Lycopene	37-45	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	285-292
16140886-7	2005	In contrast to the effects on migration and invasion, lycopene enhanced nm23-H1 expression at both the protein and mRNA levels; the effects were also bell shaped, and at 5 micromol/L, lycopene enhanced nm23-H1 protein and mRNA expressions by 220 +/- 33 and 153 +/- 22% (P &lt; 0.01), respectively.	Lycopene	54-62	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	72-79
16140886-7	2005	In contrast to the effects on migration and invasion, lycopene enhanced nm23-H1 expression at both the protein and mRNA levels; the effects were also bell shaped, and at 5 micromol/L, lycopene enhanced nm23-H1 protein and mRNA expressions by 220 +/- 33 and 153 +/- 22% (P &lt; 0.01), respectively.	Lycopene	184-192	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	202-209
16140886-10	2005	We conclude that lycopene has significant antimigration and anti-invasion activity, and that this effect is associated with its induction of nm23-H1 expression.	Lycopene	17-25	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	141-148
16030430-2	2005	The present study was undertaken to investigate the apoptosis-inducing potential of a combination of S-allylcysteine (SAC), an organosulphur constituent of garlic and lycopene, a tomato carotenoid during N-methyl-N"-nitro-N-nitroso-guanidine (MNNG) and saturated sodium chloride (S-NaCl)-induced gastric carcinogenesis in Wistar rats using the apoptosis-associated proteins Bcl-2, Bax, Bim, caspase 8 and caspase 3 as markers.	Lycopene	167-175	BCL2, apoptosis regulator	Rattus norvegicus	374-379
16030430-2	2005	The present study was undertaken to investigate the apoptosis-inducing potential of a combination of S-allylcysteine (SAC), an organosulphur constituent of garlic and lycopene, a tomato carotenoid during N-methyl-N"-nitro-N-nitroso-guanidine (MNNG) and saturated sodium chloride (S-NaCl)-induced gastric carcinogenesis in Wistar rats using the apoptosis-associated proteins Bcl-2, Bax, Bim, caspase 8 and caspase 3 as markers.	Lycopene	167-175	BCL2 associated X, apoptosis regulator	Rattus norvegicus	381-384
16030430-0	2005	Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis.	Lycopene	35-43	BCL2 associated X, apoptosis regulator	Rattus norvegicus	83-86
16030430-0	2005	Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis.	Lycopene	35-43	Bcl2-like 11	Rattus norvegicus	88-104
16030430-2	2005	The present study was undertaken to investigate the apoptosis-inducing potential of a combination of S-allylcysteine (SAC), an organosulphur constituent of garlic and lycopene, a tomato carotenoid during N-methyl-N"-nitro-N-nitroso-guanidine (MNNG) and saturated sodium chloride (S-NaCl)-induced gastric carcinogenesis in Wistar rats using the apoptosis-associated proteins Bcl-2, Bax, Bim, caspase 8 and caspase 3 as markers.	Lycopene	167-175	Bcl2-like 11	Rattus norvegicus	386-389
16030430-2	2005	The present study was undertaken to investigate the apoptosis-inducing potential of a combination of S-allylcysteine (SAC), an organosulphur constituent of garlic and lycopene, a tomato carotenoid during N-methyl-N"-nitro-N-nitroso-guanidine (MNNG) and saturated sodium chloride (S-NaCl)-induced gastric carcinogenesis in Wistar rats using the apoptosis-associated proteins Bcl-2, Bax, Bim, caspase 8 and caspase 3 as markers.	Lycopene	167-175	caspase 8	Rattus norvegicus	391-400
15769132-0	2005	Characterization of a tomato polyphenol oxidase and its role in browning and lycopene content.	Lycopene	77-85	polyphenol oxidase B, chloroplastic	Solanum lycopersicum	29-47
16030430-2	2005	The present study was undertaken to investigate the apoptosis-inducing potential of a combination of S-allylcysteine (SAC), an organosulphur constituent of garlic and lycopene, a tomato carotenoid during N-methyl-N"-nitro-N-nitroso-guanidine (MNNG) and saturated sodium chloride (S-NaCl)-induced gastric carcinogenesis in Wistar rats using the apoptosis-associated proteins Bcl-2, Bax, Bim, caspase 8 and caspase 3 as markers.	Lycopene	167-175	caspase 3	Rattus norvegicus	405-414
15951253-0	2005	Quantification by affinity perfusion chromatography of phosphorylated BRCAl and BRCA2 proteins from tumor cells after lycopene treatment.	Lycopene	118-126	BRCA2 DNA repair associated	Homo sapiens	80-85
15951253-8	2005	Treatment with 10 microM lycopene increased P-BRCA1 and P-BRCA2 in the breast tumor cell line MCF7 but not in MDA-MB-231 or MCF-10a, breast tumor or fibrocystic cell lines, respectively.	Lycopene	25-33	BRCA2 DNA repair associated	Homo sapiens	58-63
15769132-9	2005	Results from storage tests seem to relate PPO activity with color changes associated with browning and lycopene degradation, because lycopene is an antioxidant agent that reconstitutes the polyphenols oxidized by the action of PPO.	Lycopene	103-111	polyphenol oxidase B, chloroplastic	Solanum lycopersicum	42-45
15251168-1	2004	The purpose of this study was to demonstrate the effects of lycopene, the major tomato carotenoid, on the expression of the BRCA1 and BRCA2 genes in three breast tumour cell lines, MCF-7, HBL-100, MDA-MB-231 and the fibrocystic breast cell line MCF-10a.	Lycopene	60-68	BRCA1 DNA repair associated	Homo sapiens	124-129
15734720-6	2005	After washing monolayers, analyses by high-performance liquid chromatography (HPLC) showed that cellular accumulation of lycopene was 5.5 +/- 0.8, 14.0 +/- 3.2, and 36.7 +/- 12.3 pmole/10(6) cells for 0.3, 1.0, and 3.0 muM, respectively, and not detected in control cells.	Lycopene	121-129	latexin	Homo sapiens	219-222
15734720-10	2005	Subsequently, we demonstrated that increasing concentrations of lycopene significantly (P &lt; 0.05) reduced mitochondrial transmembrane potential, induced the release of mitochondrial cytochrome c, and increased annexin V binding, confirming induction of apoptosis.	Lycopene	64-72	cytochrome c, somatic	Homo sapiens	185-197
15734720-10	2005	Subsequently, we demonstrated that increasing concentrations of lycopene significantly (P &lt; 0.05) reduced mitochondrial transmembrane potential, induced the release of mitochondrial cytochrome c, and increased annexin V binding, confirming induction of apoptosis.	Lycopene	64-72	annexin A5	Homo sapiens	213-222
15545302-10	2005	In summary, we show for the first time that lycopene reduced local prostatic androgen signaling, IGF-I expression, and basal inflammatory signals in normal prostate tissue.	Lycopene	44-52	insulin-like growth factor 1	Rattus norvegicus	97-102
16573373-4	2005	In contrast, we observed no significant associations for total lycopenes, all-trans-lycopene, and cis-lycopene isomer peaks 2, 3, and 5, although high levels of cis-lycopene isomer peak 1 were inversely associated with risk.	Lycopene	161-173	pseudopodium enriched atypical kinase 1	Homo sapiens	181-187
15618424-5	2005	Tomato CRY2 overexpressors show phenotypes similar to but distinct from their Arabidopsis counterparts (hypocotyl and internode shortening under both low- and high-fluence blue light), but also several novel ones, including a high-pigment phenotype, resulting in overproduction of anthocyanins and chlorophyll in leaves and of flavonoids and lycopene in fruits.	Lycopene	342-350	cryptochrome 2	Arabidopsis thaliana	7-11
15456992-2	2004	We assessed whether dietary intake of total energy, protein, alcohol, phytoestrogens and related foods, and tomatoes and lycopene was associated with plasma levels of IGF-I and IGF binding proteins (IGFBPs) in Dutch women.	Lycopene	121-129	insulin like growth factor 1	Homo sapiens	167-172
15456992-2	2004	We assessed whether dietary intake of total energy, protein, alcohol, phytoestrogens and related foods, and tomatoes and lycopene was associated with plasma levels of IGF-I and IGF binding proteins (IGFBPs) in Dutch women.	Lycopene	121-129	insulin like growth factor binding protein 1	Homo sapiens	199-205
15336318-4	2004	After adjustment for race, sex, age, and total cholesterol, serum concentration of GGT across all deciles was inversely associated with serum concentrations of alpha-carotene, beta-carotene, beta-cryptoxanthin, zeaxanthin/lutein, lycopene, and vitamin C (p for trend &lt;.01, respectively).	Lycopene	230-238	gamma-glutamyltransferase light chain family member 3	Homo sapiens	83-86
15379981-5	2004	We found that lycopene down-regulates the expression of costimulatory molecules (CD80 and CD86) and major histocompatibility complex type II molecules.	Lycopene	14-22	CD80 antigen	Mus musculus	81-85
15379981-5	2004	We found that lycopene down-regulates the expression of costimulatory molecules (CD80 and CD86) and major histocompatibility complex type II molecules.	Lycopene	14-22	CD86 antigen	Mus musculus	90-94
15379981-6	2004	We also determined that lycopene-treated DC were poor stimulators of naive allogeneic T-cell proliferation and induced lower levels of interleukin-2 in responding T cells.	Lycopene	24-32	interleukin 2	Mus musculus	135-148
15379981-8	2004	Additionally, lycopene was able to inhibit mitogen-activated protein kinases, such as ERK1/2, p38 and JNK, and the transcription factor, nuclear factor-kappaB.	Lycopene	14-22	mitogen-activated protein kinase 3	Mus musculus	86-92
15379981-8	2004	Additionally, lycopene was able to inhibit mitogen-activated protein kinases, such as ERK1/2, p38 and JNK, and the transcription factor, nuclear factor-kappaB.	Lycopene	14-22	mitogen-activated protein kinase 14	Mus musculus	94-97
15379981-8	2004	Additionally, lycopene was able to inhibit mitogen-activated protein kinases, such as ERK1/2, p38 and JNK, and the transcription factor, nuclear factor-kappaB.	Lycopene	14-22	mitogen-activated protein kinase 8	Mus musculus	102-105
15612488-4	2004	RESULTS: Compared with model rats, SOD and GSH-Px in the group of LP administrated were increased and MDA were decreased significantly (P &lt; 0.05).	Lycopene	66-68	glutathione peroxidase 1	Rattus norvegicus	43-49
15251168-1	2004	The purpose of this study was to demonstrate the effects of lycopene, the major tomato carotenoid, on the expression of the BRCA1 and BRCA2 genes in three breast tumour cell lines, MCF-7, HBL-100, MDA-MB-231 and the fibrocystic breast cell line MCF-10a.	Lycopene	60-68	BRCA2 DNA repair associated	Homo sapiens	134-139
15251168-6	2004	These preliminary results on the effects of lycopene on the expression of BRCA1 and BRCA2 oncosuppressor genes in breast cancer may reflect cross-talk between the oestrogen and retinoic acid receptor (RAR) pathways.	Lycopene	44-52	BRCA1 DNA repair associated	Homo sapiens	74-79
15251168-6	2004	These preliminary results on the effects of lycopene on the expression of BRCA1 and BRCA2 oncosuppressor genes in breast cancer may reflect cross-talk between the oestrogen and retinoic acid receptor (RAR) pathways.	Lycopene	44-52	BRCA2 DNA repair associated	Homo sapiens	84-89
15084515-9	2004	In addition, lycopene down-regulated prostatic IGF-I and IL-6 expression.	Lycopene	13-21	insulin like growth factor 1	Homo sapiens	47-52
15084515-9	2004	In addition, lycopene down-regulated prostatic IGF-I and IL-6 expression.	Lycopene	13-21	interleukin 6	Homo sapiens	57-61
14608044-5	2003	To elucidate whether lycopene modulates cyclins involved in cell cycle progression, protein expressions of cyclins D1 and E were analyzed.	Lycopene	21-29	cyclin D1	Homo sapiens	107-123
15032813-2	2004	The hp-1 mutant was chosen for this study because the reportedly higher lycopene and ascorbic acid (AsA) contents of the fruit may alter its tolerance to photooxidative stress.	Lycopene	72-80	DNA damage-binding protein 1	Solanum lycopersicum	4-8
15032813-6	2004	Lycopene concentrations in ripe red fruit were about 5 times higher in hp-1 than in "Rutgers".	Lycopene	0-8	DNA damage-binding protein 1	Solanum lycopersicum	71-75
14652003-2	2003	After incubation with THP-1 macrophages (48h), chylomicron remnant-like particles containing lycopene (lycCRLPs) as compared to those without (CRLPs) caused significantly more lipid accumulation in the cells, and this was due to increases in both the triacylglycerol (+100%) and cholesterol (+62%) content.	Lycopene	93-101	GLI family zinc finger 2	Homo sapiens	22-27
14512033-5	2003	RESULTS: In the critically-ill group circulating concentrations of C-reactive protein and malondialdehyde were significantly higher (P&lt;0.05) and cholesterol, triglyceride, alpha-tocopherol, lutein, lycopene, alpha- and beta-carotene were all significantly lower (P&lt;0.01) compared with the control group.	Lycopene	201-209	C-reactive protein	Homo sapiens	67-85
12947436-5	2003	RESULTS: C-reactive protein concentration (dichotomized at the sex-specific 85th percentile) was inversely and significantly associated with concentrations of retinol, retinyl esters, vitamin C, alpha-carotene, beta-carotene, cryptoxanthin, lutein/zeaxanthin, lycopene, and selenium after adjustment for age, sex, race or ethnicity, education, cotinine concentration, body mass index, leisure-time physical activity, and aspirin use.	Lycopene	260-268	C-reactive protein	Homo sapiens	9-27
12930422-12	2003	CONCLUSION: Adding lycopene to orchidectomy produced a more reliable and consistent decrease in serum PSA level; it not only shrinks the primary tumour but also diminishes the secondary tumours, providing better relief from bone pain and lower urinary tract symptoms, and improving survival compared with orchidectomy alone.	Lycopene	19-27	kallikrein related peptidase 3	Homo sapiens	102-105
12968069-6	2003	We report that in this cell line, lycopene has a potentially unwanted effect of upregulating expression of the urokinase plasminogen activator receptor and facilitating invasion while failing to significantly inhibit proliferation or to induce detectable levels of the gap junctional protein connexin 43 expression.	Lycopene	34-42	plasminogen activator, urokinase receptor	Homo sapiens	111-151
12968069-6	2003	We report that in this cell line, lycopene has a potentially unwanted effect of upregulating expression of the urokinase plasminogen activator receptor and facilitating invasion while failing to significantly inhibit proliferation or to induce detectable levels of the gap junctional protein connexin 43 expression.	Lycopene	34-42	gap junction protein alpha 1	Homo sapiens	292-303
12670473-2	2003	The aim of this study was to investigate whether lycopene, a carotenoid with high anti-oxidant capacity, protects HepG2 cells expressing CYP2E1 against AA toxicity.	Lycopene	49-57	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	137-143
12921892-15	2003	A significant restoration in the activities of superoxide dismutase (P &lt; 0.05) and catalase and glutathione S-transferase (P &lt; 0.01), with no effect on glutathione peroxidase, was observed in the lycopene-supplemented group.	Lycopene	202-210	hematopoietic prostaglandin D synthase	Rattus norvegicus	99-124
12935316-0	2003	Lycopene I--effect on osteoclasts: lycopene inhibits basal and parathyroid hormone-stimulated osteoclast formation and mineral resorption mediated by reactive oxygen species in rat bone marrow cultures.	Lycopene	35-43	parathyroid hormone	Rattus norvegicus	63-82
12935316-7	2003	Results showed that lycopene inhibited TRAP + formation of multinucleated cells in both vehicle- and PTH-treated cultures.	Lycopene	20-28	acid phosphatase 5, tartrate resistant	Rattus norvegicus	39-43
12935316-10	2003	In conclusion, we have shown that lycopene inhibits basal and PTH-stimulated osteoclastic mineral resorption and formation of TRAP + multinucleated osteoclasts, as well as the ROS produced by osteoclasts.	Lycopene	34-42	acid phosphatase 5, tartrate resistant	Rattus norvegicus	126-130
12914795-0	2003	Lycopene attenuates alcoholic apoptosis in HepG2 cells expressing CYP2E1.	Lycopene	0-8	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	66-72
12810641-3	2003	However, little is known regarding whether lycopene can inhibit cigarette smoke-induced lung carcinogenesis through modulation of IGF-I/IGFBP-3, cell proliferation, and apoptosis.	Lycopene	43-51	insulin like growth factor 1	Homo sapiens	130-135
12810641-3	2003	However, little is known regarding whether lycopene can inhibit cigarette smoke-induced lung carcinogenesis through modulation of IGF-I/IGFBP-3, cell proliferation, and apoptosis.	Lycopene	43-51	insulin-like growth factor-binding protein 3	Mustela putorius furo	136-143
12810641-5	2003	We found that ferrets supplemented with lycopene and exposed to smoke had significantly higher plasma IGFBP-3 levels (P &lt; 0.01) and a lower IGF-I/IGFBP-3 ratio (P &lt; 0.01) than ferrets exposed to smoke alone.	Lycopene	40-48	insulin-like growth factor-binding protein 3	Mustela putorius furo	102-109
12810641-5	2003	We found that ferrets supplemented with lycopene and exposed to smoke had significantly higher plasma IGFBP-3 levels (P &lt; 0.01) and a lower IGF-I/IGFBP-3 ratio (P &lt; 0.01) than ferrets exposed to smoke alone.	Lycopene	40-48	insulin like growth factor 1	Homo sapiens	143-148
12810641-5	2003	We found that ferrets supplemented with lycopene and exposed to smoke had significantly higher plasma IGFBP-3 levels (P &lt; 0.01) and a lower IGF-I/IGFBP-3 ratio (P &lt; 0.01) than ferrets exposed to smoke alone.	Lycopene	40-48	insulin-like growth factor-binding protein 3	Mustela putorius furo	149-156
12810641-6	2003	Both low- and high-dose lycopene supplementations substantially inhibited smoke-induced squamous metaplasia and PCNA expression in the lungs of ferrets.	Lycopene	24-32	proliferating cell nuclear antigen	Mustela putorius furo	112-116
12810641-13	2003	In conclusion, lycopene may mediate its protective effects against smoke-induced lung carcinogenesis in ferrets through up-regulating IGFBP-3 and down-regulating phosphorylation of BAD, which promote apoptosis and inhibit cell proliferation.	Lycopene	15-23	insulin-like growth factor-binding protein 3	Mustela putorius furo	134-141
12741936-7	2003	There were significant inverse linear relationships between concentrations of CRP and plasma concentrations of the antioxidants lycopene, beta-carotene, cryptoxanthin and retinol.	Lycopene	128-136	C-reactive protein	Homo sapiens	78-81
12468619-0	2002	Lycopene inhibits proliferation and enhances gap-junction communication of KB-1 human oral tumor cells.	Lycopene	0-8	folate receptor 1 pseudogene 1	Homo sapiens	75-79
15087271-3	2003	Application of lycopene dose dependently inhibited UVB-induced ornithine decarboxylase (P &lt; 0.05) and myeloperoxidase (P &lt; 0.05) and significantly reduced bifold skin thickness (P &lt; 0.05).	Lycopene	15-23	ornithine decarboxylase 1	Homo sapiens	63-86
15087271-5	2003	Application of topical lycopene prevented the cleavage of caspase-3.	Lycopene	23-31	caspase 3	Homo sapiens	58-67
15087271-7	2003	Topical application of lycopene significantly reversed UVB-induced PCNA inhibition, and normal PCNA staining was restored in the lycopene-treated skin.	Lycopene	23-31	proliferating cell nuclear antigen	Homo sapiens	67-71
15087271-7	2003	Topical application of lycopene significantly reversed UVB-induced PCNA inhibition, and normal PCNA staining was restored in the lycopene-treated skin.	Lycopene	129-137	proliferating cell nuclear antigen	Homo sapiens	95-99
15087273-3	2003	Lycopene exerted a significant inhibitory effect on KB-1 cell proliferation inducing a dose-dependent downregulation of proliferating cell nuclear antigen (PCNA) associated with upregulation of connexin-43 (Cx-43) expression, whereas in the normal oral mucosal cells lycopene did not affect either PCNA expression, which was very low, or the expression of Cx-43, which was basically very high.	Lycopene	0-8	proliferating cell nuclear antigen	Homo sapiens	120-154
15087273-3	2003	Lycopene exerted a significant inhibitory effect on KB-1 cell proliferation inducing a dose-dependent downregulation of proliferating cell nuclear antigen (PCNA) associated with upregulation of connexin-43 (Cx-43) expression, whereas in the normal oral mucosal cells lycopene did not affect either PCNA expression, which was very low, or the expression of Cx-43, which was basically very high.	Lycopene	0-8	proliferating cell nuclear antigen	Homo sapiens	156-160
15087273-3	2003	Lycopene exerted a significant inhibitory effect on KB-1 cell proliferation inducing a dose-dependent downregulation of proliferating cell nuclear antigen (PCNA) associated with upregulation of connexin-43 (Cx-43) expression, whereas in the normal oral mucosal cells lycopene did not affect either PCNA expression, which was very low, or the expression of Cx-43, which was basically very high.	Lycopene	0-8	gap junction protein alpha 1	Homo sapiens	194-205
15087273-3	2003	Lycopene exerted a significant inhibitory effect on KB-1 cell proliferation inducing a dose-dependent downregulation of proliferating cell nuclear antigen (PCNA) associated with upregulation of connexin-43 (Cx-43) expression, whereas in the normal oral mucosal cells lycopene did not affect either PCNA expression, which was very low, or the expression of Cx-43, which was basically very high.	Lycopene	0-8	gap junction protein alpha 1	Homo sapiens	207-212
15087273-3	2003	Lycopene exerted a significant inhibitory effect on KB-1 cell proliferation inducing a dose-dependent downregulation of proliferating cell nuclear antigen (PCNA) associated with upregulation of connexin-43 (Cx-43) expression, whereas in the normal oral mucosal cells lycopene did not affect either PCNA expression, which was very low, or the expression of Cx-43, which was basically very high.	Lycopene	0-8	proliferating cell nuclear antigen	Homo sapiens	298-302
15087273-3	2003	Lycopene exerted a significant inhibitory effect on KB-1 cell proliferation inducing a dose-dependent downregulation of proliferating cell nuclear antigen (PCNA) associated with upregulation of connexin-43 (Cx-43) expression, whereas in the normal oral mucosal cells lycopene did not affect either PCNA expression, which was very low, or the expression of Cx-43, which was basically very high.	Lycopene	0-8	gap junction protein alpha 1	Homo sapiens	356-361
15087273-6	2003	Lycopene induced Cx-43 expression in KB-1 cells grown by the organotypic raft method, similar to KB-1 cells grown as monolayers.	Lycopene	0-8	gap junction protein alpha 1	Homo sapiens	17-22
12910307-1	2003	Oral treatment with lycopene (per os) in doses of 10 or 50 mg/kg for 2 weeks led to accumulation of lycopene in the liver, liver microsomes, and blood plasma, increased total plasma antioxidant activity, inhibited LPO in the liver, and decreased solubilization of lysosomal enzymes.	Lycopene	20-28	lactoperoxidase	Rattus norvegicus	214-217
14769539-0	2003	Inhibitory effects of lutein and lycopene on placental glutathione S-transferase-positive preneoplastic lesions and DNA strand breakage induced in Wistar rats by the resistant hepatocyte model of hepatocarcinogenesis.	Lycopene	33-41	hematopoietic prostaglandin D synthase	Rattus norvegicus	55-80
12468619-5	2002	Lycopene strongly and dose dependently inhibited proliferation of KB-1 human oral tumor cells.	Lycopene	0-8	folate receptor 1 pseudogene 1	Homo sapiens	66-70
12468619-7	2002	Lycopene (3 and 7 micro mol/L) significantly upregulated both the transcription (P &lt; 0.005) and the expression (P &lt; 0.05) of connexin 43, a key protein in the formation of gap-junctional communication.	Lycopene	0-8	gap junction protein alpha 1	Homo sapiens	131-142
11489752-11	2001	Expression of connexin 43 in cancerous prostate tissue was 0.63 +/- 0.19 absorbance in the lycopene group compared with 0.25 +/- 0.08 in the control group (P = 0.13).	Lycopene	91-99	gap junction protein alpha 1	Homo sapiens	14-25
12424331-7	2002	We were not able to separate the effects of lycopene from other carotenoids or antioxidants administered in this study; however, lycopene is the predominant carotenoid in V-8 (it represents 88% of total carotenoids).	Lycopene	129-137	immunoglobulin superfamily member 3	Homo sapiens	171-174
12424332-7	2002	In the second study, we assessed the association between plasma concentration of lycopene and intima-media thickness of the common carotid artery wall (CCA-IMT) in a cross-sectional analysis of the Antioxidant Supplementation in the Atherosclerosis Prevention (ASAP) study data in 520 asymptomatic men and women.	Lycopene	81-89	microtubule associated protein 9	Homo sapiens	261-265
12424335-7	2002	Studies using human and animal cells have identified a gene, connexin 43, whose expression is upregulated by lycopene and which allows direct intercellular gap junctional communication (GJC).	Lycopene	109-117	gap junction protein alpha 1	Homo sapiens	61-72
12057767-7	2002	Indeed, in the presence of 0.5-1.0 microM beta-carotene or lycopene, the UVA-induced MMP-1 mRNA was further increased by 1.5-2-fold.	Lycopene	59-67	matrix metallopeptidase 1	Homo sapiens	85-90
12057767-10	2002	Indeed, beta-carotene or lycopene (0.5-1.0 microM) led to a further 1.5-fold rise in the UVA-induced HO-1 mRNA levels.	Lycopene	25-33	heme oxygenase 1	Homo sapiens	101-105
12057767-12	2002	Lycopene and beta-carotene did not protect on their own but in the presence of vitamin E, their stability in culture was improved and the rise in MMP-1 mRNA expression was suppressed, suggesting a requirement for antioxidant protection of the carotenoids against formation of oxidative derivatives that can influence the cellular and molecular responses.	Lycopene	0-8	matrix metallopeptidase 1	Homo sapiens	146-151
12056790-7	2002	In normal subjects and cancer patients, C-reactive protein concentrations were inversely correlated with circulating concentrations of retinol (r(2)=0.162), alpha-tocopherol (r(2)=0.297), lutein (r(2)=0.256), lycopene (r(2)=-0.171), alpha-(r(2)=0.140) and beta-carotene (r(2)=0.254): (all P&lt;0.001).	Lycopene	209-217	C-reactive protein	Homo sapiens	40-58
12324296-9	2002	C-reactive protein concentrations were inversely related to beta-carotene (P &lt; 0.001), lutein and zeaxanthin (P &lt; 0.001), and lycopene (P = 0.023) concentrations.	Lycopene	132-140	C-reactive protein	Homo sapiens	0-18
12399171-2	2002	The existence of a carotenoid isomerase (CrtISO) mediating cis-to-trans isomerization has been suspected ever since the description of the tomato tangerine mutant in the early 1940s, whose fruits accumulate a poly-cis-isomer of lycopene.	Lycopene	228-236	prolycopene isomerase, chloroplastic	Solanum lycopersicum	19-39
12399171-2	2002	The existence of a carotenoid isomerase (CrtISO) mediating cis-to-trans isomerization has been suspected ever since the description of the tomato tangerine mutant in the early 1940s, whose fruits accumulate a poly-cis-isomer of lycopene.	Lycopene	228-236	prolycopene isomerase, chloroplastic	Solanum lycopersicum	41-47
12091493-6	2002	Marked carotenoid interactions were observed between LYC/beta-C and beta-C/alpha-C.	Lycopene	53-56	colony stimulating factor 2 receptor subunit beta	Homo sapiens	57-63
11868053-7	2002	A statistically significant correlation was found between lycopene and IMTmax (r = 0.42, P =.014) at univariate analysis, which persisted at multivariate analysis (P &lt;.05) and was independent of low-density lipoprotein cholesterol, creatinine clearance, and plasma insulin.	Lycopene	58-66	insulin	Homo sapiens	268-275
11840838-7	2001	Furthermore, the level of myeloperoxidase (MPO) was significantly lower in the lycopene-treated group compared to the control group.	Lycopene	79-87	myeloperoxidase	Rattus norvegicus	26-41
11840838-7	2001	Furthermore, the level of myeloperoxidase (MPO) was significantly lower in the lycopene-treated group compared to the control group.	Lycopene	79-87	myeloperoxidase	Rattus norvegicus	43-46
11588908-11	2001	The number of GST-P-positive areas within the HCC lesions was greater in the TJ-9 group than in the control or lycopene group (p = 0.024 and p = 0.012, respectively).	Lycopene	111-119	glutathione S-transferase pi 1	Rattus norvegicus	14-19
11437362-0	2001	Effects of acyclo-retinoic acid and lycopene on activation of the retinoic acid receptor and proliferation of mammary cancer cells.	Lycopene	36-44	retinoic acid receptor alpha	Homo sapiens	66-88
11437362-3	2001	The inhibition of human mammary cancer (MCF-7) cell growth and the transactivation of the retinoic acid receptor (RAR) reporter gene by synthetic acyclo-retinoic acid, the open chain analog of retinoic acid, was compared to the effects of lycopene and retinoic acid in the same systems.	Lycopene	239-247	retinoic acid receptor alpha	Homo sapiens	114-117
11226339-4	2001	We reported earlier that the Arabidopsis thaliana lycopene epsilon-cyclase (LCYe) adds one epsilon-ring to the symmetrical linear substrate lycopene, whereas the structurally related lycopene beta-cyclase (LCYb) adds two beta-rings.	Lycopene	50-58	Lycopene beta/epsilon cyclase protein	Arabidopsis thaliana	76-80
11226339-7	2001	The product of the lettuce cDNA, similar in sequence to the Arabidopsis LCYe (77% amino acid identity), efficiently converted lycopene into the bicyclic epsilon-carotene in a heterologous Escherichia coli system.	Lycopene	126-134	Lycopene beta/epsilon cyclase protein	Arabidopsis thaliana	72-76
11226339-9	2001	A single amino acid was found to act as a molecular switch: lettuce LCYe mutant H457L added only one epsilon-ring to lycopene, whereas the complementary Arabidopsis LCYe mutant, L448H, added two epsilon-rings.	Lycopene	117-125	Lycopene beta/epsilon cyclase protein	Arabidopsis thaliana	68-72
11423993-0	2001	Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27(Kip1) in the cyclin E-cdk2 complexes.	Lycopene	0-8	interferon alpha inducible protein 27	Homo sapiens	150-153
11423993-0	2001	Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27(Kip1) in the cyclin E-cdk2 complexes.	Lycopene	0-8	cyclin dependent kinase inhibitor 1B	Homo sapiens	154-158
11423993-0	2001	Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27(Kip1) in the cyclin E-cdk2 complexes.	Lycopene	0-8	cyclin dependent kinase 2	Homo sapiens	176-180
11423993-8	2001	Lycopene caused a decrease in cyclin D1 and D3 levels whereas cyclin E levels did not change.	Lycopene	0-8	cyclin D1	Homo sapiens	30-39
11423993-12	2001	These results suggest that lycopene inhibits cell cycle progression via reduction of the cyclin D level and retention of p27 in cyclin E--cdk2, thus leading to inhibition of G(1) CDK activities.	Lycopene	27-35	interferon alpha inducible protein 27	Homo sapiens	121-124
11423993-12	2001	These results suggest that lycopene inhibits cell cycle progression via reduction of the cyclin D level and retention of p27 in cyclin E--cdk2, thus leading to inhibition of G(1) CDK activities.	Lycopene	27-35	cyclin dependent kinase 2	Homo sapiens	138-142
10856518-8	2000	Pre-incubation of HAEC with beta-carotene, lutein and lycopene significantly reduced VCAM-1 expression by 29, 28, and 13%, respectively.	Lycopene	54-62	vascular cell adhesion molecule 1	Homo sapiens	85-91
10856518-10	2000	Pre-treatment with beta-carotene, lutein and lycopene significantly reduced the expression of ICAM-1 by 11, 14, and 18%, respectively.	Lycopene	45-53	intercellular adhesion molecule 1	Homo sapiens	94-100
10856518-11	2000	While other carotenoids were ineffective, lycopene attenuated both IL-1beta-stimulated and spontaneous HAEC adhesion to U937 monocytic cells by 20 and 25%, respectively.	Lycopene	42-50	interleukin 1 beta	Homo sapiens	67-75
10620348-2	2000	Lycopene, a nonprovitamin A carotenoid and its possible oxidation product, acyclo-retinoic acid, were tested for their effect on GJC, on stabilization of connexin43 mRNA, and on the transactivation of the RAR-beta2-promoter in vitro.	Lycopene	0-8	gap junction protein alpha 1	Homo sapiens	154-164
10514025-0	1999	Effect of lycopene on lipid peroxidation and glutathione-dependent enzymes induced by T-2 toxin in vivo.	Lycopene	10-18	solute carrier family 25 member 5	Homo sapiens	86-89
10798222-0	2000	Lycopene interferes with cell cycle progression and insulin-like growth factor I signaling in mammary cancer cells.	Lycopene	0-8	insulin like growth factor 1	Homo sapiens	52-80
10798222-2	2000	The aim of this study was to determine whether the mitogenic activity of IGF-I in mammary cancer cells can be reduced by the dietary carotenoid lycopene.	Lycopene	144-152	insulin like growth factor 1	Homo sapiens	73-78
10798222-4	2000	Growth stimulation of MCF7 mammary cancer cells by IGF-I was markedly reduced by physiological concentrations of lycopene.	Lycopene	113-121	insulin like growth factor 1	Homo sapiens	51-56
10798222-6	2000	Lycopene treatment markedly reduced the IGF-I stimulation of tyrosine phosphorylation of insulin receptor substrate 1 and binding capacity of the AP-1 transcription complex.	Lycopene	0-8	insulin like growth factor 1	Homo sapiens	40-45
10798222-6	2000	Lycopene treatment markedly reduced the IGF-I stimulation of tyrosine phosphorylation of insulin receptor substrate 1 and binding capacity of the AP-1 transcription complex.	Lycopene	0-8	insulin receptor substrate 1	Homo sapiens	89-117
10798222-10	2000	Collectively, the above data suggest that the inhibitory effects of lycopene on MCF7 cell growth are not due to the toxicity of the carotenoid but, rather, to interference in IGF-I receptor signaling and cell cycle progression.	Lycopene	68-76	insulin like growth factor 1 receptor	Homo sapiens	175-189
9168909-0	1997	Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages.	Lycopene	30-38	low density lipoprotein receptor	Mus musculus	128-140
9914519-0	1999	Two Arabidopsis thaliana carotene desaturases, phytoene desaturase and zeta-carotene desaturase, expressed in Escherichia coli, catalyze a poly-cis pathway to yield pro-lycopene.	Lycopene	165-177	zeta-carotene desaturase	Arabidopsis thaliana	71-95
10227052-6	1999	Lycopene alone induced cell differentiation as measured by phorbol ester-dependent reduction of nitro blue tetrazolium and expression of the cell surface antigen CD14.	Lycopene	0-8	CD14 molecule	Homo sapiens	162-166
10205893-12	1999	During fruit development, the mRNA levels for the lycopene-producing enzymes phytoene synthase (PSY) and phytoene desaturase (PDS) increase, while the mRNA levels of the genes for the lycopene beta- and epsilon-cyclases, which convert lycopene to either beta- or delta-carotene, respectively, decline and completely disappear.	Lycopene	50-58	phytoene synthase 1, chloroplastic	Solanum lycopersicum	96-99
10205893-12	1999	During fruit development, the mRNA levels for the lycopene-producing enzymes phytoene synthase (PSY) and phytoene desaturase (PDS) increase, while the mRNA levels of the genes for the lycopene beta- and epsilon-cyclases, which convert lycopene to either beta- or delta-carotene, respectively, decline and completely disappear.	Lycopene	50-58	15-cis-phytoene desaturase, chloroplastic/chromoplastic	Solanum lycopersicum	105-124
9725998-0	1998	Inhibition of PhIP mutagenicity by caffeine, lycopene, daidzein, and genistein.	Lycopene	45-53	pleckstrin homology domain interacting protein	Homo sapiens	14-18
9725998-6	1998	Other antioxidants such as lycopene, the active antioxidant from tomatoes, and daidzein and genistein from soy products, also had a dose-related inhibition of the mutagenicity of PhIP.	Lycopene	27-35	pleckstrin homology domain interacting protein	Homo sapiens	179-183
9639691-12	1998	Finally, it could be demonstrated that the number of BaP or CP induced micronuclei in polychromatic erythrocytes in bone-marrow of mice was reduced significantly by the carotenoids lycopene, canthaxanthin, lutein and beta-cryptoxanthin (25-46%).	Lycopene	181-189	prohibitin 2	Mus musculus	53-56
9526506-6	1998	Sepals of fruit on transgenic tomato plants that expressed TAG1 ectopically were induced by low temperature to ripen in vivo, producing lycopene and undergoing cell wall softening as is characteristic of pericarpic tissue.	Lycopene	136-144	floral homeotic protein AGAMOUS	Solanum lycopersicum	59-63
9268918-11	1997	Alpha-carotene, canthaxanthin and lycopene also inhibited cell proliferation at 1 microM and increased alkaline phosphatase activity and osteopontin mRNA expression, but less potently so than beta-carotene.	Lycopene	34-42	secreted phosphoprotein 1	Mus musculus	137-148
9168909-5	1997	However, unlike LDL derived cholesterol, which also suppresses macrophage LDL receptor activity, lycopene and beta-carotene augmented the activity of the macrophage LDL receptor, similarly to the effect of fluvasfatin.	Lycopene	97-105	low density lipoprotein receptor	Mus musculus	165-177
8910913-10	1996	With unprimed spleen cells, lycopene suppressed Th2 clone-mediated Ab production.	Lycopene	28-36	heart and neural crest derivatives expressed 2	Mus musculus	48-51
8883384-2	1996	The mRNA for HMG2 accumulates to high level during fruit ripening, in a pattern that coincides with the synthesis of the carotenoid lycopene.	Lycopene	132-140	3-hydroxy-3-methylglutaryl-coenzyme A reductase 2	Solanum lycopersicum	13-17
9075202-5	1997	In contrast, the phenoxyl radicals generated from phenol (by native myeloperoxidase in HL-60 cells or HRP/H2O2 in model systems) effectively oxidized beta-carotene and other carotenoids (canthaxanthin, lutein, lycopene).	Lycopene	210-218	myeloperoxidase	Homo sapiens	68-83
9110357-7	1997	Acetaminophen use (p = 0.05), coffee consumption (p = 0.05) and plasma lycopene (p = 0.06) were positively associated with CYP1A2 activity.	Lycopene	71-79	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	123-129
9383786-8	1997	Lycopene does not appear to act through its antioxidant properties, but rather through its modulating effect on the liver enzyme activating DEN, cytochrome P-450 2E1.	Lycopene	0-8	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	145-165
8740725-5	1996	The peripheral CD4/CD8 ratio was partially augmented by lycopene treatment which resulted from an increased CD4+ subpopulation.	Lycopene	56-64	CD4 antigen	Mus musculus	15-18
8740725-5	1996	The peripheral CD4/CD8 ratio was partially augmented by lycopene treatment which resulted from an increased CD4+ subpopulation.	Lycopene	56-64	CD4 antigen	Mus musculus	108-111
34530111-0	2022	Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1.	Lycopene	0-8	insulin	Homo sapiens	21-28
1281116-5	1992	Physical quenchers of singlet oxygen such as lycopene, beta-carotene, and alpha-tocopherol all reduced the calphostin C-induced inactivation of PKC.	Lycopene	45-53	proline rich transmembrane protein 2	Homo sapiens	144-147
33034714-7	2021	Moreover, lycopene reduced the hepatic levels of thiobarbituric acid reactive substances and tumor necrosis factor-alpha as well as the hepatic activity of myeloperoxidase that were markedly elevated by EE.	Lycopene	10-18	tumor necrosis factor	Rattus norvegicus	93-120
33034714-7	2021	Moreover, lycopene reduced the hepatic levels of thiobarbituric acid reactive substances and tumor necrosis factor-alpha as well as the hepatic activity of myeloperoxidase that were markedly elevated by EE.	Lycopene	10-18	myeloperoxidase	Rattus norvegicus	156-171
34988307-6	2022	Moreover, dietary supplementation of 200 mg/kg lycopene significantly increased slow myosin heavy chain (MyHC) protein level and slow-twitch fiber percentage, and decreased fast MyHC protein level and fast-twitch fiber percentage (P < 0.05), suggesting that the addition of 200 mg/kg lycopene to the diet of finishing pigs promoted muscle fiber type conversion from fast-twitch to slow-twitch.	Lycopene	47-55	myosin heavy chain 3	Sus scrofa	85-103
34988307-6	2022	Moreover, dietary supplementation of 200 mg/kg lycopene significantly increased slow myosin heavy chain (MyHC) protein level and slow-twitch fiber percentage, and decreased fast MyHC protein level and fast-twitch fiber percentage (P < 0.05), suggesting that the addition of 200 mg/kg lycopene to the diet of finishing pigs promoted muscle fiber type conversion from fast-twitch to slow-twitch.	Lycopene	47-55	myosin heavy chain 3	Sus scrofa	105-109
34988307-6	2022	Moreover, dietary supplementation of 200 mg/kg lycopene significantly increased slow myosin heavy chain (MyHC) protein level and slow-twitch fiber percentage, and decreased fast MyHC protein level and fast-twitch fiber percentage (P < 0.05), suggesting that the addition of 200 mg/kg lycopene to the diet of finishing pigs promoted muscle fiber type conversion from fast-twitch to slow-twitch.	Lycopene	284-292	myosin heavy chain 3	Sus scrofa	85-103
34988307-6	2022	Moreover, dietary supplementation of 200 mg/kg lycopene significantly increased slow myosin heavy chain (MyHC) protein level and slow-twitch fiber percentage, and decreased fast MyHC protein level and fast-twitch fiber percentage (P < 0.05), suggesting that the addition of 200 mg/kg lycopene to the diet of finishing pigs promoted muscle fiber type conversion from fast-twitch to slow-twitch.	Lycopene	284-292	myosin heavy chain 3	Sus scrofa	105-109
34699919-0	2022	Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1/PINK1/mitophagy axis and mitochondrial unfolded protein response.	Lycopene	0-8	sirtuin 1	Mus musculus	94-99
34699919-0	2022	Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1/PINK1/mitophagy axis and mitochondrial unfolded protein response.	Lycopene	0-8	PTEN induced putative kinase 1	Mus musculus	100-105
34530111-0	2022	Lycopene ameliorates insulin resistance and increases muscle capillary density in aging via activation of SIRT1.	Lycopene	0-8	sirtuin 1	Homo sapiens	106-111
34716962-8	2022	Lycopene also increased Treg differentiation in splenic naive CD4+ T cells.	Lycopene	0-8	CD4 antigen	Mus musculus	62-65
34716962-10	2022	The expression levels of IL4, IL-9, and IL-13 mRNA in colonic mucosa were also significantly reduced by lycopene.	Lycopene	104-112	interleukin 4	Mus musculus	25-28
34716962-10	2022	The expression levels of IL4, IL-9, and IL-13 mRNA in colonic mucosa were also significantly reduced by lycopene.	Lycopene	104-112	interleukin 9	Mus musculus	30-34
34716962-10	2022	The expression levels of IL4, IL-9, and IL-13 mRNA in colonic mucosa were also significantly reduced by lycopene.	Lycopene	104-112	interleukin 13	Mus musculus	40-45
34716962-11	2022	IL-9 is known to induce proliferation of mast cells, and we found that lycopene-feeding significantly reduced the number of mast cells in the colonic mucosa of FA mice.	Lycopene	71-79	interleukin 9	Mus musculus	0-4
34964896-0	2022	beta-carotene Oxygenase 2 Genotype Modulates the Impact of Dietary Lycopene On Gene Expression During Early TRAMP Prostate Carcinogenesis.	Lycopene	67-75	dermatopontin	Mus musculus	108-113
34964896-2	2022	Genetically-driven murine prostate carcinogenesis (TRAMP model) is inhibited by lycopene- or tomato-feeding, and these effects are modulated by beta-carotene oxygenase 2 (Bco2) genotype.	Lycopene	80-88	dermatopontin	Mus musculus	51-56
34964896-7	2022	In comparison, lycopene- and tomato-feeding modestly modulate strong procarcinogenic TRAMP signaling.	Lycopene	15-23	aquaporin PIP1-5	Solanum lycopersicum	85-90
34964896-9	2022	The impact of Bco2 genotype was limited to a subset of lycopene-impacted genes (Apc, Mto1, Nfkb1, and Rbm39).	Lycopene	55-63	beta-carotene oxygenase 2	Mus musculus	14-18
34670089-0	2021	Lycopene Preventing DEHP-Induced Renal Cell Damage Is Targeted by Aryl Hydrocarbon Receptor.	Lycopene	0-8	aryl-hydrocarbon receptor	Mus musculus	66-91
34945647-8	2021	The synergistic group (lycopene:quercetin = 1:5) increased the expression of SR-BI compared to individual lycopene treatment in HUVEC and Caco-2 cells.	Lycopene	23-31	scavenger receptor class B member 1	Homo sapiens	77-82
34945647-8	2021	The synergistic group (lycopene:quercetin = 1:5) increased the expression of SR-BI compared to individual lycopene treatment in HUVEC and Caco-2 cells.	Lycopene	106-114	scavenger receptor class B member 1	Homo sapiens	77-82
34571190-0	2021	Maintaining blood retinal barrier homeostasis to attenuate retinal ischemia-reperfusion injury by targeting the KEAP1/NRF2/ARE pathway with lycopene.	Lycopene	140-148	kelch like ECH associated protein 1	Homo sapiens	112-117
34571190-0	2021	Maintaining blood retinal barrier homeostasis to attenuate retinal ischemia-reperfusion injury by targeting the KEAP1/NRF2/ARE pathway with lycopene.	Lycopene	140-148	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
34848692-9	2021	On the other hand, the expression of the carotenoid biosynthesis genes SlPSY1 and SlZISO was also suppressed and directly regulated by SlZHD17, which induced uneven pigmentation and decreased the lycopene content in fruits with SlZHD17 suppression at the ripe stage.	Lycopene	196-204	phytoene synthase 1, chloroplastic	Solanum lycopersicum	71-77
34729976-3	2021	Notably, when compared to the DSS group, the protein expression levels of TLR4, TRIF, and p-NF-kappaB p65 in the mice colon tissue were downregulated and those of tight junction-related proteins were upregulated in the LP + DSS group, with the most significant effect observed in the 10 mg/kg LP + DSS group.	Lycopene	219-221	toll-like receptor adaptor molecule 2	Mus musculus	80-84
34729976-3	2021	Notably, when compared to the DSS group, the protein expression levels of TLR4, TRIF, and p-NF-kappaB p65 in the mice colon tissue were downregulated and those of tight junction-related proteins were upregulated in the LP + DSS group, with the most significant effect observed in the 10 mg/kg LP + DSS group.	Lycopene	293-295	toll-like receptor 4	Mus musculus	74-78
34729976-3	2021	Notably, when compared to the DSS group, the protein expression levels of TLR4, TRIF, and p-NF-kappaB p65 in the mice colon tissue were downregulated and those of tight junction-related proteins were upregulated in the LP + DSS group, with the most significant effect observed in the 10 mg/kg LP + DSS group.	Lycopene	293-295	toll-like receptor adaptor molecule 2	Mus musculus	80-84
34729976-4	2021	These results confirmed that the upregulation of tight junction-related protein expression after blocking the TLR4/TRIF/NF-kappaB signaling pathway may be one of the mechanisms through which LP prevents UC.	Lycopene	191-193	toll-like receptor 4	Mus musculus	110-114
34729976-4	2021	These results confirmed that the upregulation of tight junction-related protein expression after blocking the TLR4/TRIF/NF-kappaB signaling pathway may be one of the mechanisms through which LP prevents UC.	Lycopene	191-193	toll-like receptor adaptor molecule 2	Mus musculus	115-119
34729976-4	2021	These results confirmed that the upregulation of tight junction-related protein expression after blocking the TLR4/TRIF/NF-kappaB signaling pathway may be one of the mechanisms through which LP prevents UC.	Lycopene	191-193	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-129
34098435-0	2021	pH-Dependent complexation between beta-lactoglobulin and lycopene: Multi-spectroscopy, molecular docking and dynamic simulation study.	Lycopene	57-65	phenylalanine hydroxylase	Homo sapiens	0-2
34098435-1	2021	This study aims to investigate the effect of pH levels (pH 7.0 and pH 8.1) on binding ability of beta-lactoglobulin (beta-LG) with lycopene (LYC) and elucidate interaction mechanisms using multi-spectroscopy and molecular docking study.	Lycopene	131-139	phenylalanine hydroxylase	Homo sapiens	45-47
34098435-1	2021	This study aims to investigate the effect of pH levels (pH 7.0 and pH 8.1) on binding ability of beta-lactoglobulin (beta-LG) with lycopene (LYC) and elucidate interaction mechanisms using multi-spectroscopy and molecular docking study.	Lycopene	131-139	phenylalanine hydroxylase	Homo sapiens	56-58
34098435-1	2021	This study aims to investigate the effect of pH levels (pH 7.0 and pH 8.1) on binding ability of beta-lactoglobulin (beta-LG) with lycopene (LYC) and elucidate interaction mechanisms using multi-spectroscopy and molecular docking study.	Lycopene	131-139	phenylalanine hydroxylase	Homo sapiens	67-69
34098435-1	2021	This study aims to investigate the effect of pH levels (pH 7.0 and pH 8.1) on binding ability of beta-lactoglobulin (beta-LG) with lycopene (LYC) and elucidate interaction mechanisms using multi-spectroscopy and molecular docking study.	Lycopene	141-144	phenylalanine hydroxylase	Homo sapiens	45-47
34098435-1	2021	This study aims to investigate the effect of pH levels (pH 7.0 and pH 8.1) on binding ability of beta-lactoglobulin (beta-LG) with lycopene (LYC) and elucidate interaction mechanisms using multi-spectroscopy and molecular docking study.	Lycopene	141-144	phenylalanine hydroxylase	Homo sapiens	56-58
34098435-1	2021	This study aims to investigate the effect of pH levels (pH 7.0 and pH 8.1) on binding ability of beta-lactoglobulin (beta-LG) with lycopene (LYC) and elucidate interaction mechanisms using multi-spectroscopy and molecular docking study.	Lycopene	141-144	phenylalanine hydroxylase	Homo sapiens	67-69
34874147-5	2021	As compared to the native Cu2+-inducible CUP1 promoter, the CuIGR4 system amplified the response to copper by as much as 2.7 folds, resulting in 72-fold induction of EGFP expression and a 33-fold change in lycopene production (3-100 mg/L) with addition of 20 muM copper.	Lycopene	206-214	metallothionein CUP1	Saccharomyces cerevisiae S288C	41-45
34945647-4	2021	Lycopene combined with quercetin at ratio 1:5 showed stronger ROS scavenging activities, increased 18, 12, and 12 Cellular antioxidant activity (CAA) units in HUVEC, Caco-2, and L-02 cells, respectively, and promoted SOD and CAT activities than individual component.	Lycopene	0-8	catalase	Homo sapiens	225-228
34866548-5	2021	In the duodenum, interleukin-1beta (IL-1beta), nuclear factor-kappaB and tumor necrosis factor-alpha contents were decreased (p < 0.05) in 200 mg/kg lycopene group.	Lycopene	149-157	interleukin-1 beta	Sus scrofa	17-34
34866548-5	2021	In the duodenum, interleukin-1beta (IL-1beta), nuclear factor-kappaB and tumor necrosis factor-alpha contents were decreased (p < 0.05) in 200 mg/kg lycopene group.	Lycopene	149-157	interleukin-1 beta	Sus scrofa	36-44
34866548-6	2021	In the jejunum, IL-1beta content was reduced (p < 0.05) and IL-1beta mRNA expression was down-regulated (p = 0.046) in 200 mg/kg lycopene group.	Lycopene	129-137	interleukin-1 beta	Sus scrofa	16-24
34866548-6	2021	In the jejunum, IL-1beta content was reduced (p < 0.05) and IL-1beta mRNA expression was down-regulated (p = 0.046) in 200 mg/kg lycopene group.	Lycopene	129-137	interleukin-1 beta	Sus scrofa	60-68
34729976-0	2021	Preventive Effect of Lycopene in Dextran Sulfate Sodium-Induced Ulcerative Colitis Mice through the Regulation of TLR4/TRIF/NF-kappaB Signaling Pathway and Tight Junctions.	Lycopene	21-29	toll-like receptor 4	Mus musculus	114-118
34729976-0	2021	Preventive Effect of Lycopene in Dextran Sulfate Sodium-Induced Ulcerative Colitis Mice through the Regulation of TLR4/TRIF/NF-kappaB Signaling Pathway and Tight Junctions.	Lycopene	21-29	toll-like receptor adaptor molecule 2	Mus musculus	119-123
34729976-0	2021	Preventive Effect of Lycopene in Dextran Sulfate Sodium-Induced Ulcerative Colitis Mice through the Regulation of TLR4/TRIF/NF-kappaB Signaling Pathway and Tight Junctions.	Lycopene	21-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	124-133
34729976-3	2021	Notably, when compared to the DSS group, the protein expression levels of TLR4, TRIF, and p-NF-kappaB p65 in the mice colon tissue were downregulated and those of tight junction-related proteins were upregulated in the LP + DSS group, with the most significant effect observed in the 10 mg/kg LP + DSS group.	Lycopene	219-221	toll-like receptor 4	Mus musculus	74-78
34670089-10	2021	In addition, LYC treatment reduced nuclear accumulation of DEHP-induced aromatic hydrocarbon receptor (AhR) and AhR nuclear transporter (Arnt), and its downstream target genes such as cytochrome P450-dependent monooxygenase (CYP) 1A1, 1A2, and 1B1 expression significantly decreased to normal in the LYC treatment group.	Lycopene	13-16	aryl-hydrocarbon receptor	Mus musculus	103-106
34670089-10	2021	In addition, LYC treatment reduced nuclear accumulation of DEHP-induced aromatic hydrocarbon receptor (AhR) and AhR nuclear transporter (Arnt), and its downstream target genes such as cytochrome P450-dependent monooxygenase (CYP) 1A1, 1A2, and 1B1 expression significantly decreased to normal in the LYC treatment group.	Lycopene	13-16	aryl hydrocarbon receptor nuclear translocator	Mus musculus	112-135
34670089-10	2021	In addition, LYC treatment reduced nuclear accumulation of DEHP-induced aromatic hydrocarbon receptor (AhR) and AhR nuclear transporter (Arnt), and its downstream target genes such as cytochrome P450-dependent monooxygenase (CYP) 1A1, 1A2, and 1B1 expression significantly decreased to normal in the LYC treatment group.	Lycopene	13-16	aryl hydrocarbon receptor nuclear translocator	Mus musculus	137-141
34670089-10	2021	In addition, LYC treatment reduced nuclear accumulation of DEHP-induced aromatic hydrocarbon receptor (AhR) and AhR nuclear transporter (Arnt), and its downstream target genes such as cytochrome P450-dependent monooxygenase (CYP) 1A1, 1A2, and 1B1 expression significantly decreased to normal in the LYC treatment group.	Lycopene	13-16	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	184-238
34859851-4	2021	RESULTS: In osteogenic medium, lycopene supplementation dose-dependently enhanced osteoblast differentiation, as evidenced by the transcription of Alpl, Runx2, Col1a1, Sp7, and Bglap, higher alkaline phosphatase activity, osteocalcin secretion and extracellular matrix mineralisation seen with Alizarin red S staining, and increased haem oxygenase levels.	Lycopene	31-39	alkaline phosphatase, biomineralization associated	Rattus norvegicus	147-151
34386819-9	2021	RESULTS: Serum concentrations of lycopene (52% lower), phytoene (26% lower), and alpha-tocopherol (22% lower) were decreased in TP-fed irradiated mice (TP-Rad) compared with TP-fed sham mice (P < 0.05).	Lycopene	33-41	Ras-related associated with diabetes	Mus musculus	155-158
34796193-7	2021	Through transcriptomics and translatomics joint analysis, we narrowed the range of functional genes to 112 DEGs and found that lycopene may affect lipid metabolism by regulating the expression of LPIN1 at the transcriptional and translational levels.	Lycopene	127-135	lipin 1	Mus musculus	196-201
34859851-4	2021	RESULTS: In osteogenic medium, lycopene supplementation dose-dependently enhanced osteoblast differentiation, as evidenced by the transcription of Alpl, Runx2, Col1a1, Sp7, and Bglap, higher alkaline phosphatase activity, osteocalcin secretion and extracellular matrix mineralisation seen with Alizarin red S staining, and increased haem oxygenase levels.	Lycopene	31-39	RUNX family transcription factor 2	Rattus norvegicus	153-158
34859851-4	2021	RESULTS: In osteogenic medium, lycopene supplementation dose-dependently enhanced osteoblast differentiation, as evidenced by the transcription of Alpl, Runx2, Col1a1, Sp7, and Bglap, higher alkaline phosphatase activity, osteocalcin secretion and extracellular matrix mineralisation seen with Alizarin red S staining, and increased haem oxygenase levels.	Lycopene	31-39	collagen type I alpha 1 chain	Rattus norvegicus	160-166
34859851-4	2021	RESULTS: In osteogenic medium, lycopene supplementation dose-dependently enhanced osteoblast differentiation, as evidenced by the transcription of Alpl, Runx2, Col1a1, Sp7, and Bglap, higher alkaline phosphatase activity, osteocalcin secretion and extracellular matrix mineralisation seen with Alizarin red S staining, and increased haem oxygenase levels.	Lycopene	31-39	Sp7 transcription factor	Rattus norvegicus	168-171
34859851-4	2021	RESULTS: In osteogenic medium, lycopene supplementation dose-dependently enhanced osteoblast differentiation, as evidenced by the transcription of Alpl, Runx2, Col1a1, Sp7, and Bglap, higher alkaline phosphatase activity, osteocalcin secretion and extracellular matrix mineralisation seen with Alizarin red S staining, and increased haem oxygenase levels.	Lycopene	31-39	bone gamma-carboxyglutamate protein	Rattus norvegicus	177-182
34859851-4	2021	RESULTS: In osteogenic medium, lycopene supplementation dose-dependently enhanced osteoblast differentiation, as evidenced by the transcription of Alpl, Runx2, Col1a1, Sp7, and Bglap, higher alkaline phosphatase activity, osteocalcin secretion and extracellular matrix mineralisation seen with Alizarin red S staining, and increased haem oxygenase levels.	Lycopene	31-39	bone gamma-carboxyglutamate protein	Rattus norvegicus	222-233
34859851-5	2021	By contrast, lycopene in adipogenic medium inhibited adipocyte differentiation evidenced by decreases in the transcription of Tnfsf11, Tnfrsf11b, Pparg, Lpl, and Fabp4 and reduced fat accumulation observed by Oil Red O staining.	Lycopene	13-21	TNF superfamily member 11	Rattus norvegicus	126-133
34859851-5	2021	By contrast, lycopene in adipogenic medium inhibited adipocyte differentiation evidenced by decreases in the transcription of Tnfsf11, Tnfrsf11b, Pparg, Lpl, and Fabp4 and reduced fat accumulation observed by Oil Red O staining.	Lycopene	13-21	TNF receptor superfamily member 11B	Rattus norvegicus	135-144
34859851-5	2021	By contrast, lycopene in adipogenic medium inhibited adipocyte differentiation evidenced by decreases in the transcription of Tnfsf11, Tnfrsf11b, Pparg, Lpl, and Fabp4 and reduced fat accumulation observed by Oil Red O staining.	Lycopene	13-21	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	146-151
34859851-5	2021	By contrast, lycopene in adipogenic medium inhibited adipocyte differentiation evidenced by decreases in the transcription of Tnfsf11, Tnfrsf11b, Pparg, Lpl, and Fabp4 and reduced fat accumulation observed by Oil Red O staining.	Lycopene	13-21	lipoprotein lipase	Rattus norvegicus	153-156
34859851-5	2021	By contrast, lycopene in adipogenic medium inhibited adipocyte differentiation evidenced by decreases in the transcription of Tnfsf11, Tnfrsf11b, Pparg, Lpl, and Fabp4 and reduced fat accumulation observed by Oil Red O staining.	Lycopene	13-21	fatty acid binding protein 4	Rattus norvegicus	162-167
34224857-0	2021	Lycopene attenuates Staphylococcus aureus-induced inflammation via inhibiting alpha-Hemolysin expression.	Lycopene	0-8	AT695_RS11870	Staphylococcus aureus	78-93
34479060-10	2021	Histopathological study with hematoxylin-eosin staining and cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9), vasoactive intestinal peptide (VIP) expression found that lycopene suppresses inflammation with both nasal administration and increased dose.	Lycopene	180-188	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	60-76
34479060-10	2021	Histopathological study with hematoxylin-eosin staining and cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9), vasoactive intestinal peptide (VIP) expression found that lycopene suppresses inflammation with both nasal administration and increased dose.	Lycopene	180-188	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	78-83
34479060-10	2021	Histopathological study with hematoxylin-eosin staining and cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9), vasoactive intestinal peptide (VIP) expression found that lycopene suppresses inflammation with both nasal administration and increased dose.	Lycopene	180-188	matrix metallopeptidase 9	Rattus norvegicus	86-112
34479060-10	2021	Histopathological study with hematoxylin-eosin staining and cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9), vasoactive intestinal peptide (VIP) expression found that lycopene suppresses inflammation with both nasal administration and increased dose.	Lycopene	180-188	matrix metallopeptidase 9	Rattus norvegicus	114-119
34479060-10	2021	Histopathological study with hematoxylin-eosin staining and cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9), vasoactive intestinal peptide (VIP) expression found that lycopene suppresses inflammation with both nasal administration and increased dose.	Lycopene	180-188	vasoactive intestinal peptide	Rattus norvegicus	122-151
34479060-10	2021	Histopathological study with hematoxylin-eosin staining and cyclooxygenase-2 (COX-2), matrix metalloproteinase-9 (MMP-9), vasoactive intestinal peptide (VIP) expression found that lycopene suppresses inflammation with both nasal administration and increased dose.	Lycopene	180-188	vasoactive intestinal peptide	Rattus norvegicus	153-156
34224857-9	2021	In conclusion, Lycopene restrains S. aureus-induced inflammation via inhibiting alpha-Hemolysin expression.	Lycopene	15-23	AT695_RS11870	Staphylococcus aureus	80-95
34573125-0	2021	Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling.	Lycopene	0-8	kelch-like ECH-associated protein 1	Mus musculus	100-105
34925809-10	2021	In the lycopene group (10 mg/kg), sperm concentration, the levels of TAC, and catalase (CAT) activity were improved so the levels of ROS, MDA, and %DNA damage were reduced compared with varicocele group.	Lycopene	7-15	catalase	Rattus norvegicus	78-86
34925809-10	2021	In the lycopene group (10 mg/kg), sperm concentration, the levels of TAC, and catalase (CAT) activity were improved so the levels of ROS, MDA, and %DNA damage were reduced compared with varicocele group.	Lycopene	7-15	catalase	Rattus norvegicus	88-91
34611420-8	2021	Only alpha-carotene, trans-beta-carotene, cis-beta-carotene, trans-lycopene and retinol were associated with HE4, with beta coefficients of -0.102, -0.027, -0.506, -0.131 and -0.054, respectively.	Lycopene	61-75	WAP four-disulfide core domain 2	Homo sapiens	109-112
34633271-14	2021	These findings were also improved by immunohistochemical analysis of GFAP, VEGF, caspase3, and histopathological examinations, in which pretreatment of rats with lycopene and chrysin reversed all clonidine-induced alterations.	Lycopene	162-170	glial fibrillary acidic protein	Rattus norvegicus	69-73
34633271-14	2021	These findings were also improved by immunohistochemical analysis of GFAP, VEGF, caspase3, and histopathological examinations, in which pretreatment of rats with lycopene and chrysin reversed all clonidine-induced alterations.	Lycopene	162-170	vascular endothelial growth factor A	Rattus norvegicus	75-79
34633271-14	2021	These findings were also improved by immunohistochemical analysis of GFAP, VEGF, caspase3, and histopathological examinations, in which pretreatment of rats with lycopene and chrysin reversed all clonidine-induced alterations.	Lycopene	162-170	caspase 3	Rattus norvegicus	81-89
34378595-4	2021	Lycopene supplementation reduced the plasma TG, LEP and AST levels (P < 0.05).	Lycopene	0-8	leptin	Rattus norvegicus	48-51
34378595-6	2021	Lycopene increased the activity of HSL and the expression of ATGL in the liver (P < 0.05), and the activity of ACC and mRNA expression of HMGCR and ACC were decreased (P < 0.05).	Lycopene	0-8	lipase E, hormone sensitive type	Rattus norvegicus	35-38
34378595-6	2021	Lycopene increased the activity of HSL and the expression of ATGL in the liver (P < 0.05), and the activity of ACC and mRNA expression of HMGCR and ACC were decreased (P < 0.05).	Lycopene	0-8	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	138-143
34378595-9	2021	Maternal lycopene supplementation decreased the activities of ACC and FAS in the liver and decreased the expression of PPARgamma, ACC and PLIN1 (P < 0.05).	Lycopene	9-17	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	119-128
34378595-9	2021	Maternal lycopene supplementation decreased the activities of ACC and FAS in the liver and decreased the expression of PPARgamma, ACC and PLIN1 (P < 0.05).	Lycopene	9-17	perilipin 1	Rattus norvegicus	138-143
34573125-0	2021	Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling.	Lycopene	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	106-110
34428895-0	2021	Lycopene Reduces Cholesterol Absorption and Prevents Atherosclerosis in ApoE-/- Mice by Downregulating HNF-1alpha and NPC1L1 Expression.	Lycopene	0-8	apolipoprotein E	Mus musculus	72-76
34428895-0	2021	Lycopene Reduces Cholesterol Absorption and Prevents Atherosclerosis in ApoE-/- Mice by Downregulating HNF-1alpha and NPC1L1 Expression.	Lycopene	0-8	HNF1 homeobox A	Mus musculus	103-113
34428895-0	2021	Lycopene Reduces Cholesterol Absorption and Prevents Atherosclerosis in ApoE-/- Mice by Downregulating HNF-1alpha and NPC1L1 Expression.	Lycopene	0-8	NPC1 like intracellular cholesterol transporter 1	Mus musculus	118-124
34428895-1	2021	Our previous study showed that lycopene reduced the absorption of cholesterol in Caco-2 cells through inhibiting Niemann-Pick C1-Like 1 (NPC1L1) expression.	Lycopene	31-39	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	137-143
34428895-6	2021	Lycopene also downregulated the expression of NPC1L1 and hepatocyte nuclear factor-1alpha (HNF-1alpha) in the small intestine.	Lycopene	0-8	NPC1 like intracellular cholesterol transporter 1	Mus musculus	46-52
34428895-6	2021	Lycopene also downregulated the expression of NPC1L1 and hepatocyte nuclear factor-1alpha (HNF-1alpha) in the small intestine.	Lycopene	0-8	HNF1 homeobox A	Mus musculus	57-89
34428895-6	2021	Lycopene also downregulated the expression of NPC1L1 and hepatocyte nuclear factor-1alpha (HNF-1alpha) in the small intestine.	Lycopene	0-8	HNF1 homeobox A	Mus musculus	91-101
34428895-8	2021	These results indicated that lycopene inhibited intestinal cholesterol absorption and protected against HFD-induced atherosclerosis through inhibiting HNF-1alpha and NPC1L1 expression.	Lycopene	29-37	HNF1 homeobox A	Mus musculus	151-161
34428895-8	2021	These results indicated that lycopene inhibited intestinal cholesterol absorption and protected against HFD-induced atherosclerosis through inhibiting HNF-1alpha and NPC1L1 expression.	Lycopene	29-37	NPC1 like intracellular cholesterol transporter 1	Mus musculus	166-172
34545285-1	2021	Objective: To investigate the effects of lycopene-loaded microemulsion (LME) on the cognitive function and neurogenesis in the dentate gyrus (DG) of the hippocampus and subventricular (SVZ) region of rats with amyloid beta- (Abeta-) induced Alzheimer"s disease (AD) and its mechanism based on the Wnt/beta-catenin pathway.	Lycopene	41-49	Wnt family member 3A	Rattus norvegicus	297-300
34545285-1	2021	Objective: To investigate the effects of lycopene-loaded microemulsion (LME) on the cognitive function and neurogenesis in the dentate gyrus (DG) of the hippocampus and subventricular (SVZ) region of rats with amyloid beta- (Abeta-) induced Alzheimer"s disease (AD) and its mechanism based on the Wnt/beta-catenin pathway.	Lycopene	41-49	amyloid beta precursor protein	Rattus norvegicus	225-230
34545285-1	2021	Objective: To investigate the effects of lycopene-loaded microemulsion (LME) on the cognitive function and neurogenesis in the dentate gyrus (DG) of the hippocampus and subventricular (SVZ) region of rats with amyloid beta- (Abeta-) induced Alzheimer"s disease (AD) and its mechanism based on the Wnt/beta-catenin pathway.	Lycopene	41-49	catenin beta 1	Rattus norvegicus	301-313
34545285-0	2021	Lycopene-Loaded Microemulsion Regulates Neurogenesis in Rats with Abeta-Induced Alzheimer"s Disease Rats Based on the Wnt/beta-catenin Pathway.	Lycopene	0-8	Wnt family member 3A	Rattus norvegicus	118-121
34294819-5	2021	Palmitic acid overload caused significant (p < 0.05) increases in adenosine deaminase, monoamine oxidase-A, nucleotides tri-phosphatase, 5"-nucleotidase, acetylcholine esterase, and myeloperoxidase activities, and malondialdehyde (MDA) levels which were reduced significantly in the lycopene-treated groups.	Lycopene	283-291	myeloperoxidase	Rattus norvegicus	137-197
34545285-0	2021	Lycopene-Loaded Microemulsion Regulates Neurogenesis in Rats with Abeta-Induced Alzheimer"s Disease Rats Based on the Wnt/beta-catenin Pathway.	Lycopene	0-8	catenin beta 1	Rattus norvegicus	122-134
34485361-5	2021	In lycopene experimental groups, the amount of gastric juice were lower than that in the gastric injury control group; the levels of T-SOD, and the levels of MDA and inflammatory factors (MMP-9 and MCP-1) decreased.	Lycopene	3-11	matrix metallopeptidase 9	Mus musculus	188-193
34485361-5	2021	In lycopene experimental groups, the amount of gastric juice were lower than that in the gastric injury control group; the levels of T-SOD, and the levels of MDA and inflammatory factors (MMP-9 and MCP-1) decreased.	Lycopene	3-11	mast cell protease 1	Mus musculus	198-203
34485361-8	2021	In lycopene control group, the levels of MTL, T-SOD, and NO increased, but the levels of ALT and AST decreased, indicating that lycopene has a protective effect on the stomach and liver when ethanol wasn"t taken.	Lycopene	128-136	glutamic pyruvic transaminase, soluble	Mus musculus	89-92
34165166-0	2021	Lycopene prevents oxygen-glucose deprivation-induced autophagic death in SH-SY5Y cells via inhibition of the oxidative stress-activated AMPK/mTOR pathway.	Lycopene	0-8	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	136-140
34165166-0	2021	Lycopene prevents oxygen-glucose deprivation-induced autophagic death in SH-SY5Y cells via inhibition of the oxidative stress-activated AMPK/mTOR pathway.	Lycopene	0-8	mechanistic target of rapamycin kinase	Homo sapiens	141-145
34165166-7	2021	Notably, lycopene was shown not only to prevent OGD-induced SH-SY5Y cell death, but was also able to effectively inhibit OGD-induced upregulation of ATG5 and LC3II, and downregulation of p62 in a dose-dependent manner.	Lycopene	9-17	autophagy related 5	Homo sapiens	149-153
34165166-7	2021	Notably, lycopene was shown not only to prevent OGD-induced SH-SY5Y cell death, but was also able to effectively inhibit OGD-induced upregulation of ATG5 and LC3II, and downregulation of p62 in a dose-dependent manner.	Lycopene	9-17	nucleoporin 62	Homo sapiens	187-190
34165166-8	2021	Mechanistically, it was suggested that lycopene inhibited OGD-induced activation of the AMPK/mTOR pathway via attenuation of oxidative stress by maintaining the intracellular antioxidant glutathione (GSH).	Lycopene	39-47	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	88-92
34165166-8	2021	Mechanistically, it was suggested that lycopene inhibited OGD-induced activation of the AMPK/mTOR pathway via attenuation of oxidative stress by maintaining the intracellular antioxidant glutathione (GSH).	Lycopene	39-47	mechanistic target of rapamycin kinase	Homo sapiens	93-97
34165166-9	2021	Furthermore, the inhibitory role of lycopene in GSH depletion was found to be associated with the prevention of OGD-induced depletion of intracellular cysteine and downregulation of xCT.	Lycopene	36-44	solute carrier family 7 member 11	Homo sapiens	182-185
34165166-10	2021	Collectively, the present study demonstrated that lycopene protected SH-SY5Y cells against OGD-induced autophagic death by inhibiting oxidative stress-dependent activation of the AMPK/mTOR pathway.	Lycopene	50-58	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	179-183
34165166-10	2021	Collectively, the present study demonstrated that lycopene protected SH-SY5Y cells against OGD-induced autophagic death by inhibiting oxidative stress-dependent activation of the AMPK/mTOR pathway.	Lycopene	50-58	mechanistic target of rapamycin kinase	Homo sapiens	184-188
34294819-8	2021	Furthermore, upregulated expressions of Interleukin-1beta, Interleukin-6, and NF-kB-p65 in the PA control were attenuated, while decreased Interleukine-10 expression was upregulated due to lycopene treatment.	Lycopene	189-197	interleukin 1 beta	Rattus norvegicus	40-57
34294819-8	2021	Furthermore, upregulated expressions of Interleukin-1beta, Interleukin-6, and NF-kB-p65 in the PA control were attenuated, while decreased Interleukine-10 expression was upregulated due to lycopene treatment.	Lycopene	189-197	interleukin 6	Rattus norvegicus	59-72
34294819-8	2021	Furthermore, upregulated expressions of Interleukin-1beta, Interleukin-6, and NF-kB-p65 in the PA control were attenuated, while decreased Interleukine-10 expression was upregulated due to lycopene treatment.	Lycopene	189-197	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	78-84
34294819-8	2021	Furthermore, upregulated expressions of Interleukin-1beta, Interleukin-6, and NF-kB-p65 in the PA control were attenuated, while decreased Interleukine-10 expression was upregulated due to lycopene treatment.	Lycopene	189-197	synaptotagmin 1	Rattus norvegicus	84-87
34294819-10	2021	This study concludes that lycopene ameliorated PA-induced neuroinflammation, probably via attenuation of oxidative stress, and downregulation of TLR4/ NF-kappaB -p65 axis.	Lycopene	26-34	toll-like receptor 4	Rattus norvegicus	145-149
34294819-10	2021	This study concludes that lycopene ameliorated PA-induced neuroinflammation, probably via attenuation of oxidative stress, and downregulation of TLR4/ NF-kappaB -p65 axis.	Lycopene	26-34	synaptotagmin 1	Rattus norvegicus	162-165
34138692-6	2021	The effect of thymoquinone and lycopene compounds on the GR activity purified from human erythrocytes was researched.	Lycopene	31-39	glutathione-disulfide reductase	Homo sapiens	57-59
34138692-0	2021	Inhibition effect of thymoquinone and lycopene compounds on glutathione reductase enzyme activity purified from human erythrocytes.	Lycopene	38-46	glutathione-disulfide reductase	Homo sapiens	60-81
34138692-12	2021	In this study, it was concluded that antioxidant compounds thymoquinone and lycopene, which have an inhibitory effect on GR activity, may have a therapeutic effect on cancer disease.	Lycopene	76-84	glutathione-disulfide reductase	Homo sapiens	121-123
35533600-0	2022	Lycopene enhances the sensitivity of castration-resistant prostate cancer to enzalutamide through the AKT/EZH2/ androgen receptor signaling pathway.	Lycopene	0-8	AKT serine/threonine kinase 1	Homo sapiens	102-105
34311540-6	2021	The effect mechanisms of lycopene are related to the regulation of several signal transduction pathways, such as PI3K/Akt pathway, modulation of insulin-like growth factors system, the suppression of activity of sex steroid hormones, the modification of relevant gene expression, and the alteration of mitochondrial function.	Lycopene	25-33	AKT serine/threonine kinase 1	Homo sapiens	118-121
34311540-6	2021	The effect mechanisms of lycopene are related to the regulation of several signal transduction pathways, such as PI3K/Akt pathway, modulation of insulin-like growth factors system, the suppression of activity of sex steroid hormones, the modification of relevant gene expression, and the alteration of mitochondrial function.	Lycopene	25-33	insulin	Homo sapiens	145-152
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Lycopene	179-187	interleukin 1 alpha	Rattus norvegicus	44-52
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Lycopene	179-187	interleukin 2	Rattus norvegicus	54-58
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Lycopene	179-187	interleukin 6	Rattus norvegicus	60-64
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Lycopene	179-187	tumor necrosis factor	Rattus norvegicus	66-74
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Lycopene	179-187	mast cell protease 1-like 1	Rattus norvegicus	76-80
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Lycopene	179-187	C-C motif chemokine ligand 3	Rattus norvegicus	85-95
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Lycopene	354-362	interleukin 1 alpha	Rattus norvegicus	44-52
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Lycopene	354-362	interleukin 2	Rattus norvegicus	54-58
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Lycopene	354-362	interleukin 6	Rattus norvegicus	60-64
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Lycopene	354-362	tumor necrosis factor	Rattus norvegicus	66-74
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Lycopene	354-362	mast cell protease 1-like 1	Rattus norvegicus	76-80
34914324-7	2021	The expressions of the inflammatory factors IL-1beta, IL-2, IL-6, TNFalpha, MCP1 and MIP-1alpha in the prostate tissue were all dramatically decreased in the quercetin, curcumin, lycopene and combination therapy groups compared with those in the normal controls (P < 0.01), even lower in the combination therapy group than in the quercetin, curcumin and lycopene groups (P < 0.05).	Lycopene	354-362	C-C motif chemokine ligand 3	Rattus norvegicus	85-95
34914324-10	2021	Conclusions: Lycopene combined with quercetin and curcumin is more effective than any of the three drugs used alone in the treatment of CP/CPPS, which may be associated with its alleviation of inflammatory response and oxidative stress by interaction between the NF-kappaB, MAPKs and Nrf2 signaling pathways.	Lycopene	13-21	NFE2 like bZIP transcription factor 2	Rattus norvegicus	284-288
34095308-8	2021	After analyzing stability and reactivity, 5 phytochemicals, i.e., SilybinC, Isopomiferin, Lycopene, SilydianinB, and Silydianin are identified as novel and potent candidates for the inhibition of HR1 domain in SARS-CoV-2 spike protein.	Lycopene	90-98	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	221-226
35533600-0	2022	Lycopene enhances the sensitivity of castration-resistant prostate cancer to enzalutamide through the AKT/EZH2/ androgen receptor signaling pathway.	Lycopene	0-8	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	106-110
35533600-0	2022	Lycopene enhances the sensitivity of castration-resistant prostate cancer to enzalutamide through the AKT/EZH2/ androgen receptor signaling pathway.	Lycopene	0-8	androgen receptor	Homo sapiens	112-129
35533600-6	2022	In addition, the expression of p-AKT, p-EZH2 and androgen receptor (AR) were significantly down-regulated in 22RV1 and C4-2B cells and the proliferation and invasion of CRPC cells were inhibited after treatment with lycopene, while SC79 (an AKT agonist) markedly rescue this effect.	Lycopene	216-224	AKT serine/threonine kinase 1	Homo sapiens	33-36
35533600-6	2022	In addition, the expression of p-AKT, p-EZH2 and androgen receptor (AR) were significantly down-regulated in 22RV1 and C4-2B cells and the proliferation and invasion of CRPC cells were inhibited after treatment with lycopene, while SC79 (an AKT agonist) markedly rescue this effect.	Lycopene	216-224	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	40-44
35533600-6	2022	In addition, the expression of p-AKT, p-EZH2 and androgen receptor (AR) were significantly down-regulated in 22RV1 and C4-2B cells and the proliferation and invasion of CRPC cells were inhibited after treatment with lycopene, while SC79 (an AKT agonist) markedly rescue this effect.	Lycopene	216-224	androgen receptor	Homo sapiens	49-66
35533600-6	2022	In addition, the expression of p-AKT, p-EZH2 and androgen receptor (AR) were significantly down-regulated in 22RV1 and C4-2B cells and the proliferation and invasion of CRPC cells were inhibited after treatment with lycopene, while SC79 (an AKT agonist) markedly rescue this effect.	Lycopene	216-224	androgen receptor	Homo sapiens	68-70
35533600-6	2022	In addition, the expression of p-AKT, p-EZH2 and androgen receptor (AR) were significantly down-regulated in 22RV1 and C4-2B cells and the proliferation and invasion of CRPC cells were inhibited after treatment with lycopene, while SC79 (an AKT agonist) markedly rescue this effect.	Lycopene	216-224	AKT serine/threonine kinase 1	Homo sapiens	241-244
35533600-8	2022	These results suggest that the enhanced antitumor effects of enzalutamide by lycopene may be related to the reduction of AR protein levels through lycopene-mediated inhibition of AKT/EZH2 pathway, which may provide a new approach to improve the efficacy of enzalutamide in CRPC.	Lycopene	77-85	androgen receptor	Homo sapiens	121-123
35533600-8	2022	These results suggest that the enhanced antitumor effects of enzalutamide by lycopene may be related to the reduction of AR protein levels through lycopene-mediated inhibition of AKT/EZH2 pathway, which may provide a new approach to improve the efficacy of enzalutamide in CRPC.	Lycopene	77-85	AKT serine/threonine kinase 1	Homo sapiens	179-182
35533600-8	2022	These results suggest that the enhanced antitumor effects of enzalutamide by lycopene may be related to the reduction of AR protein levels through lycopene-mediated inhibition of AKT/EZH2 pathway, which may provide a new approach to improve the efficacy of enzalutamide in CRPC.	Lycopene	77-85	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	183-187
35533600-8	2022	These results suggest that the enhanced antitumor effects of enzalutamide by lycopene may be related to the reduction of AR protein levels through lycopene-mediated inhibition of AKT/EZH2 pathway, which may provide a new approach to improve the efficacy of enzalutamide in CRPC.	Lycopene	147-155	androgen receptor	Homo sapiens	121-123
35533600-8	2022	These results suggest that the enhanced antitumor effects of enzalutamide by lycopene may be related to the reduction of AR protein levels through lycopene-mediated inhibition of AKT/EZH2 pathway, which may provide a new approach to improve the efficacy of enzalutamide in CRPC.	Lycopene	147-155	AKT serine/threonine kinase 1	Homo sapiens	179-182
35533600-8	2022	These results suggest that the enhanced antitumor effects of enzalutamide by lycopene may be related to the reduction of AR protein levels through lycopene-mediated inhibition of AKT/EZH2 pathway, which may provide a new approach to improve the efficacy of enzalutamide in CRPC.	Lycopene	147-155	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	183-187
35183682-0	2022	The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling.	Lycopene	51-59	Kelch-like ECH-associated protein 1	Rattus norvegicus	162-167
35183682-0	2022	The combination of nicotinamide mononucleotide and lycopene prevents cognitive impairment and attenuates oxidative damage in D-galactose induced aging models via Keap1-Nrf2 signaling.	Lycopene	51-59	NFE2 like bZIP transcription factor 2	Rattus norvegicus	168-172
34999039-0	2022	Co-delivery of siRNA and lycopene encapsulated hybrid lipid nanoparticles for dual silencing of insulin-like growth factor 1 receptor in MCF-7 breast cancer cell line.	Lycopene	25-33	insulin like growth factor 1 receptor	Homo sapiens	96-133
35120355-10	2022	In addition, lycopene upregulated endothelial nitric oxide synthase (eNOS), protein kinase B (Akt) and phosphatidylinositol 3-kinases (PI3K), and downregulated vascular endothelial growth factor receptor 2 (VEGFR-2) protein expressions (p<0.05) in the livers of the BDL rats.	Lycopene	13-21	nitric oxide synthase 3	Rattus norvegicus	34-67
35120355-10	2022	In addition, lycopene upregulated endothelial nitric oxide synthase (eNOS), protein kinase B (Akt) and phosphatidylinositol 3-kinases (PI3K), and downregulated vascular endothelial growth factor receptor 2 (VEGFR-2) protein expressions (p<0.05) in the livers of the BDL rats.	Lycopene	13-21	nitric oxide synthase 3	Rattus norvegicus	69-73
35120355-10	2022	In addition, lycopene upregulated endothelial nitric oxide synthase (eNOS), protein kinase B (Akt) and phosphatidylinositol 3-kinases (PI3K), and downregulated vascular endothelial growth factor receptor 2 (VEGFR-2) protein expressions (p<0.05) in the livers of the BDL rats.	Lycopene	13-21	AKT serine/threonine kinase 1	Rattus norvegicus	94-97
35120355-10	2022	In addition, lycopene upregulated endothelial nitric oxide synthase (eNOS), protein kinase B (Akt) and phosphatidylinositol 3-kinases (PI3K), and downregulated vascular endothelial growth factor receptor 2 (VEGFR-2) protein expressions (p<0.05) in the livers of the BDL rats.	Lycopene	13-21	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	103-133
35120355-10	2022	In addition, lycopene upregulated endothelial nitric oxide synthase (eNOS), protein kinase B (Akt) and phosphatidylinositol 3-kinases (PI3K), and downregulated vascular endothelial growth factor receptor 2 (VEGFR-2) protein expressions (p<0.05) in the livers of the BDL rats.	Lycopene	13-21	kinase insert domain receptor	Rattus norvegicus	160-205
35120355-10	2022	In addition, lycopene upregulated endothelial nitric oxide synthase (eNOS), protein kinase B (Akt) and phosphatidylinositol 3-kinases (PI3K), and downregulated vascular endothelial growth factor receptor 2 (VEGFR-2) protein expressions (p<0.05) in the livers of the BDL rats.	Lycopene	13-21	kinase insert domain receptor	Rattus norvegicus	207-214
35120355-11	2022	CONCLUSION: Lycopene ameliorated liver fibrosis, hyperdynamic circulation and pathological angiogenesis in biliary cirrhotic rats, possibly through the modulation of intrahepatic Akt/PI3K/eNOS and VEGFR-2 pathways.	Lycopene	12-20	AKT serine/threonine kinase 1	Rattus norvegicus	179-182
35120355-11	2022	CONCLUSION: Lycopene ameliorated liver fibrosis, hyperdynamic circulation and pathological angiogenesis in biliary cirrhotic rats, possibly through the modulation of intrahepatic Akt/PI3K/eNOS and VEGFR-2 pathways.	Lycopene	12-20	nitric oxide synthase 3	Rattus norvegicus	188-192
35120355-11	2022	CONCLUSION: Lycopene ameliorated liver fibrosis, hyperdynamic circulation and pathological angiogenesis in biliary cirrhotic rats, possibly through the modulation of intrahepatic Akt/PI3K/eNOS and VEGFR-2 pathways.	Lycopene	12-20	kinase insert domain receptor	Rattus norvegicus	197-204
35260874-0	2022	Lycopene ameliorates atrazine-induced pyroptosis in spleen by suppressing the Ox-mtDNA/Nlrp3 inflammasome pathway.	Lycopene	0-8	NLR family pyrin domain containing 3	Homo sapiens	87-92
35260874-9	2022	The results also provided evidence that lycopene had a potential role in the prevention of Nlrp3 inflammasome activation by depleting the ox-mtDNA.	Lycopene	40-48	NLR family pyrin domain containing 3	Homo sapiens	91-96
35445391-9	2022	Results showed that lycopene promoted an increase in ALP in situ detection as well as a significant increase in mineralized nodules deposition and expression of genes Runx2 and Bglap when compared with the OVX group.	Lycopene	20-28	PDZ and LIM domain 3	Rattus norvegicus	53-56
35445391-9	2022	Results showed that lycopene promoted an increase in ALP in situ detection as well as a significant increase in mineralized nodules deposition and expression of genes Runx2 and Bglap when compared with the OVX group.	Lycopene	20-28	RUNX family transcription factor 2	Rattus norvegicus	167-172
35445391-9	2022	Results showed that lycopene promoted an increase in ALP in situ detection as well as a significant increase in mineralized nodules deposition and expression of genes Runx2 and Bglap when compared with the OVX group.	Lycopene	20-28	bone gamma-carboxyglutamate protein	Rattus norvegicus	177-182
35192223-0	2022	The effects of lycopene supplementation on insulin-like growth factor-1 and insulin-like growth factor binding proteins: A systematic review of randomized controlled trials.	Lycopene	15-23	insulin like growth factor 1	Homo sapiens	43-71
35192223-1	2022	Lycopene has been posited to regulate insulin-like growth factor-1 (IGF-1).	Lycopene	0-8	insulin like growth factor 1	Homo sapiens	38-66
35192223-1	2022	Lycopene has been posited to regulate insulin-like growth factor-1 (IGF-1).	Lycopene	0-8	insulin like growth factor 1	Homo sapiens	68-73
35192223-2	2022	We aimed to conduct a systematic review of the effects of lycopene on circulating IGF-1 and insulin-like growth factor binding proteins (IGFBPs) in adults.	Lycopene	58-66	insulin like growth factor 1	Homo sapiens	82-87
35192223-2	2022	We aimed to conduct a systematic review of the effects of lycopene on circulating IGF-1 and insulin-like growth factor binding proteins (IGFBPs) in adults.	Lycopene	58-66	insulin like growth factor binding protein 1	Homo sapiens	137-143
35192223-5	2022	Eleven studies examined the effect of lycopene supplementation on IGF-1, one of which reported a significant reduction.	Lycopene	38-46	insulin like growth factor 1	Homo sapiens	66-71
35192223-8	2022	More research is needed to explore the effect of lycopene on IGF-1 system.	Lycopene	49-57	insulin like growth factor 1	Homo sapiens	61-66
35592276-10	2022	Although the administration of lycopene (10 mg/kg) in rats with varicocele improved sperm viability and membrane integrity, Johnson"s score, and Bax expression compared to the varicocele group.	Lycopene	31-39	BCL2 associated X, apoptosis regulator	Rattus norvegicus	145-148
35222796-0	2022	Lycopene Improves Bone Quality and Regulates AGE/RAGE/NF-kB Signaling Pathway in High-Fat Diet-Induced Obese Mice.	Lycopene	0-8	renin binding protein	Mus musculus	45-48
35151443-3	2022	To decipher whether PSY2-mediated carotenogenesis operates in ripening fruits, we blocked the in vivo activity of lycopene-beta-cyclases in fruits of several carotenoids and ripening mutants by CPTA (2-(4-Chlorophenylthio)triethylamine hydrochloride), an inhibitor of lycopene-beta-cyclases.	Lycopene	114-122	phytoene synthase 2, chloroplastic	Solanum lycopersicum	20-24
35222796-0	2022	Lycopene Improves Bone Quality and Regulates AGE/RAGE/NF-kB Signaling Pathway in High-Fat Diet-Induced Obese Mice.	Lycopene	0-8	advanced glycosylation end product-specific receptor	Mus musculus	49-53
35222796-11	2022	Conclusion: Lycopene may improve bone quality through its antioxidant properties, which may be linked with the regulation of the AGE/RAGE/NF-kB signaling pathway in obese mice.	Lycopene	12-20	renin binding protein	Mus musculus	129-132
35222796-11	2022	Conclusion: Lycopene may improve bone quality through its antioxidant properties, which may be linked with the regulation of the AGE/RAGE/NF-kB signaling pathway in obese mice.	Lycopene	12-20	advanced glycosylation end product-specific receptor	Mus musculus	133-137
35096612-9	2021	In the placebo arm, significant associations were observed among men with higher serum lycopene for APEX1-rs1760944 and NQO1-rs1800566, or higher serum beta-cryptoxanthin for ERCC4-rs1800067.	Lycopene	87-95	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	100-105
35164673-13	2022	CONCLUSION: Taken together, this study firstly confirmed PD-L1 expression and signaling are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in TSCC.	Lycopene	106-114	mitogen-activated protein kinase 1	Homo sapiens	140-143
35164673-0	2022	Programmed death-ligand 1 signaling and expression are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in tongue squamous cell carcinoma.	Lycopene	69-77	AKT serine/threonine kinase 1	Homo sapiens	87-90
35164673-0	2022	Programmed death-ligand 1 signaling and expression are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in tongue squamous cell carcinoma.	Lycopene	69-77	zinc fingers and homeoboxes 2	Homo sapiens	95-98
35164673-0	2022	Programmed death-ligand 1 signaling and expression are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in tongue squamous cell carcinoma.	Lycopene	69-77	mitogen-activated protein kinase kinase 7	Homo sapiens	99-102
35164673-0	2022	Programmed death-ligand 1 signaling and expression are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in tongue squamous cell carcinoma.	Lycopene	69-77	mitogen-activated protein kinase 1	Homo sapiens	103-106
35164673-3	2022	On the other hand, lycopene showed antitumor effects and chemotherapy/radiotherapy-enhancing effects by mechanisms closely correlated with PD-L1.	Lycopene	19-27	CD274 molecule	Homo sapiens	139-144
35164673-4	2022	PURPOSE: We aimed to explore whether the mechanisms of PD-L1 signaling and regulation are reversible by lycopene treatment in TSCC.	Lycopene	104-112	CD274 molecule	Homo sapiens	55-60
35164673-12	2022	Lycopene reversed PD-L1 signaling and expression by mechanisms opposite to PD-L1 upregulation but similar to PD-L1 knockdown.	Lycopene	0-8	CD274 molecule	Homo sapiens	18-23
35164673-13	2022	CONCLUSION: Taken together, this study firstly confirmed PD-L1 expression and signaling are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in TSCC.	Lycopene	106-114	CD274 molecule	Homo sapiens	57-62
35164673-13	2022	CONCLUSION: Taken together, this study firstly confirmed PD-L1 expression and signaling are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in TSCC.	Lycopene	106-114	AKT serine/threonine kinase 1	Homo sapiens	124-127
35164673-13	2022	CONCLUSION: Taken together, this study firstly confirmed PD-L1 expression and signaling are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in TSCC.	Lycopene	106-114	zinc fingers and homeoboxes 2	Homo sapiens	132-135
35164673-13	2022	CONCLUSION: Taken together, this study firstly confirmed PD-L1 expression and signaling are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in TSCC.	Lycopene	106-114	mitogen-activated protein kinase kinase 7	Homo sapiens	136-139
35096612-10	2021	In the finasteride arm, stronger associations were observed among men with lower serum lycopene for NOS3-rs1799983, higher serum alpha-carotene, beta-carotene, and beta-cryptoxanthin for LIG3-rs1052536, or lower serum retinol for SOD2-rs1799725.	Lycopene	87-95	nitric oxide synthase 3	Homo sapiens	100-104
35282004-0	2022	New associations of serum beta-carotene, lycopene, and zeaxanthin concentrations with NR1H3, APOB, RDH12, AND CYP genes.	Lycopene	41-49	nuclear receptor subfamily 1 group H member 3	Homo sapiens	86-91
35282004-0	2022	New associations of serum beta-carotene, lycopene, and zeaxanthin concentrations with NR1H3, APOB, RDH12, AND CYP genes.	Lycopene	41-49	peptidylprolyl isomerase G	Homo sapiens	110-113
35282004-9	2022	Retinol dehydrogenase 12 (RDH12) "functional partner" polymorphism rs756473 (p = 7.422 x 10-5) was associated with higher lycopene concentration.	Lycopene	122-130	retinol dehydrogenase 12	Homo sapiens	0-24
35282004-9	2022	Retinol dehydrogenase 12 (RDH12) "functional partner" polymorphism rs756473 (p = 7.422 x 10-5) was associated with higher lycopene concentration.	Lycopene	122-130	retinol dehydrogenase 12	Homo sapiens	26-31
35282004-12	2022	Zeaxanthin, lycopene, and beta-carotene serum concentrations might depend on genetic variation in NR1H3, APOB, RDH12 and CYP2C9, CYP2C18, and CYP2C19 genes.	Lycopene	12-20	retinol dehydrogenase 12	Homo sapiens	111-116