PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
14519098-6	2003	Northern blot analysis also revealed that the expression of the eel testis 11beta-HSD2 gene could be induced by human chorionic gonadotropin (hCG) injection, implying a role of 11beta-HSD2 in hCG-induced 11-ketotestosterone production and spermatogenesis in the Japanese eel.	11-ketotestosterone	204-223	chorionic gonadotropin subunit beta 5	Homo sapiens	118-146
17942797-10	2008	We also combined theoretical modeling with in vitro experiments to show that the zebrafish Ar is preferentially activated by 11-ketotestosterone.	11-ketotestosterone	125-144	androgen receptor	Danio rerio	91-93
18162527-0	2008	Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.	11-ketotestosterone	125-144	cytochrome P450, family 11, subfamily b, polypeptide 1	Mus musculus	0-7
18162527-3	2008	Expression of Cyp11b1 in rodent gonads caused the production of 11-ketotestosterone (11-KT), a major fish androgen, which induces male differentiation or spermatogenesis in fish.	11-ketotestosterone	64-83	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	14-21
18162527-3	2008	Expression of Cyp11b1 in rodent gonads caused the production of 11-ketotestosterone (11-KT), a major fish androgen, which induces male differentiation or spermatogenesis in fish.	11-ketotestosterone	85-90	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	14-21
16107211-0	2005	Molecular cloning and characterization of a nuclear androgen receptor activated by 11-ketotestosterone.	11-ketotestosterone	83-102	androgen receptor	Homo sapiens	52-69
16107211-9	2005	However, comparison of the trans-activation potential of the stickleback androgen receptor with the human androgen receptor, in both human HepG2 cells and zebrafish ZFL cells, revealed preferential activation by 11-ketotestosterone of the stickleback receptor, but not of the human receptor.	11-ketotestosterone	212-231	androgen receptor	Homo sapiens	73-90
16107211-9	2005	However, comparison of the trans-activation potential of the stickleback androgen receptor with the human androgen receptor, in both human HepG2 cells and zebrafish ZFL cells, revealed preferential activation by 11-ketotestosterone of the stickleback receptor, but not of the human receptor.	11-ketotestosterone	212-231	androgen receptor	Homo sapiens	106-123
14519098-6	2003	Northern blot analysis also revealed that the expression of the eel testis 11beta-HSD2 gene could be induced by human chorionic gonadotropin (hCG) injection, implying a role of 11beta-HSD2 in hCG-induced 11-ketotestosterone production and spermatogenesis in the Japanese eel.	11-ketotestosterone	204-223	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	177-188
10464240-3	1999	We have previously identified 11-ketotestosterone (a potent androgen in teleosts) as the spermatogenesis-inducing hormone of the Japanese eel and have cloned its receptor (eAR1) cDNA from eel testis.	11-ketotestosterone	30-49	nuclear receptor subfamily 1 group D member 1	Homo sapiens	172-176
12714013-5	2003	Human chorionic gonadotropin (hCG) stimulated in vitro production of 11-ketotestosterone (11-KT) in the testicular fragments around the full moon.	11-ketotestosterone	69-88	glycoprotein hormones, alpha polypeptide	Homo sapiens	30-33
11399470-6	2001	The production of 11-ketotestosterone (11-KT) increased significantly when the testicular fragments were incubated with hCG at the first lunar quarter, while incubation of sperm preparations with 17alpha-OHP during the same moon phase resulted in a significant increase in 17alpha,20beta-dihydroxy-4-pregnen-3-one (DHP) production in the medium.	11-ketotestosterone	18-37	chorionic gonadotropin subunit beta 5	Homo sapiens	120-123
11399470-6	2001	The production of 11-ketotestosterone (11-KT) increased significantly when the testicular fragments were incubated with hCG at the first lunar quarter, while incubation of sperm preparations with 17alpha-OHP during the same moon phase resulted in a significant increase in 17alpha,20beta-dihydroxy-4-pregnen-3-one (DHP) production in the medium.	11-ketotestosterone	39-44	chorionic gonadotropin subunit beta 5	Homo sapiens	120-123
14519098-6	2003	Northern blot analysis also revealed that the expression of the eel testis 11beta-HSD2 gene could be induced by human chorionic gonadotropin (hCG) injection, implying a role of 11beta-HSD2 in hCG-induced 11-ketotestosterone production and spermatogenesis in the Japanese eel.	11-ketotestosterone	204-223	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	75-86
3666426-7	1987	Within 1 week after hCG injection, plasma levels of free and glucuroconjugated androgens (testosterone and 11-oxotestosterone) rose significantly in intact and hypophysectomized fish.	11-ketotestosterone	107-125	chorionic gonadotropin subunit beta 5	Homo sapiens	20-23
1936914-3	1991	Testis fragments incubated in vitro respond to hCG in a time- and dose-dependent manner with a resultant increase in the secretion of testosterone (T) and 11-ketotestosterone (11-KT).	11-ketotestosterone	155-174	chorionic gonadotropin subunit beta 5	Homo sapiens	47-50
10491628-0	1999	Recombinant human insulin-like growth factor I stimulates all stages of 11-ketotestosterone-induced spermatogenesis in the Japanese eel, Anguilla japonica, in vitro.	11-ketotestosterone	72-91	insulin like growth factor 1	Homo sapiens	18-46
34951635-11	2022	In multivariable analysis, 11-OHT and 11-KetoT, directly, and FT, inversely, remained significant independent predictors of insulin sensitivity.	11-ketotestosterone	38-46	insulin	Homo sapiens	124-131
32629108-0	2020	The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1.	11-ketotestosterone	24-43	aldo-keto reductase family 1 member D1	Homo sapiens	72-78
33974560-2	2021	Studies have identified 11-ketotestosterone (11KT) as a potent AR agonist, but it is unknown if 11KT is present at physiologically-relevant concentrations in CRPC patients to drive AR activation.	11-ketotestosterone	24-43	androgen receptor	Homo sapiens	63-65
33974560-2	2021	Studies have identified 11-ketotestosterone (11KT) as a potent AR agonist, but it is unknown if 11KT is present at physiologically-relevant concentrations in CRPC patients to drive AR activation.	11-ketotestosterone	45-49	androgen receptor	Homo sapiens	63-65
33444228-11	2021	Conclusions: 11-Oxygenated androgens are the preferred substrates for androgen activation by AKR1C3 in PBMCs, primarily conveyed by natural killer cell AKR1C3 activity, yielding 11-ketotestosterone the major active androgen in PBMCs.	11-ketotestosterone	178-197	aldo-keto reductase family 1 member C3	Homo sapiens	93-99
33444228-11	2021	Conclusions: 11-Oxygenated androgens are the preferred substrates for androgen activation by AKR1C3 in PBMCs, primarily conveyed by natural killer cell AKR1C3 activity, yielding 11-ketotestosterone the major active androgen in PBMCs.	11-ketotestosterone	178-197	aldo-keto reductase family 1 member C3	Homo sapiens	152-158
31955242-10	2020	In addition, in vitro gonadal culture with 17alpha-methyltetosterone (MT) and 11-ketotestosterone (11-KT) administration and in vivo knockout of cyp11c1 demonstrated that igf3 expression is regulated by androgens, suggesting that Igf3 acts downstream of androgens in fish spermatogenesis.	11-ketotestosterone	78-97	insulin-like growth factor 3	Danio rerio	171-175
32629108-0	2020	The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1.	11-ketotestosterone	24-43	steroid 5 alpha-reductase 2	Homo sapiens	83-89
32629108-0	2020	The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1.	11-ketotestosterone	24-43	steroid 5 alpha-reductase 1	Homo sapiens	98-104
32629108-5	2020	We show that inactivation of 11-ketotestosterone is predominantly driven by AKR1D1, which efficiently catalyses the 5beta-reduction of 11-ketotestosterone, committing it to a metabolic pathway that terminates in 11-ketoetiocholanolone.	11-ketotestosterone	29-48	aldo-keto reductase family 1 member D1	Homo sapiens	76-82
32629108-5	2020	We show that inactivation of 11-ketotestosterone is predominantly driven by AKR1D1, which efficiently catalyses the 5beta-reduction of 11-ketotestosterone, committing it to a metabolic pathway that terminates in 11-ketoetiocholanolone.	11-ketotestosterone	135-154	aldo-keto reductase family 1 member D1	Homo sapiens	76-82
32629108-6	2020	We demonstrate that 5alpha-reduction of 11-ketotestosterone is catalysed by SRD5A2, but not SRD5A1, and terminates in 11-ketoandrosterone, but is only responsible for a minority of 11-ketotestosterone inactivation.	11-ketotestosterone	40-59	steroid 5 alpha-reductase 2	Homo sapiens	76-82
32629108-6	2020	We demonstrate that 5alpha-reduction of 11-ketotestosterone is catalysed by SRD5A2, but not SRD5A1, and terminates in 11-ketoandrosterone, but is only responsible for a minority of 11-ketotestosterone inactivation.	11-ketotestosterone	40-59	steroid 5 alpha-reductase 1	Homo sapiens	92-98
32001324-7	2020	It is proposed that the effects of hCG on ovarian development in previtellogenic eels could be indirect as a significant increase in plasma levels of 11-ketotestosterone (11-KT) was found in eels treated with hCG.	11-ketotestosterone	150-169	chorionic gonadotropin subunit beta 5	Homo sapiens	35-38
32222764-0	2020	Zebrafish cyp11c1 knockout reveals the roles of 11-ketotestosterone and cortisol in sexual development and reproduction.	11-ketotestosterone	48-67	cytochrome P450, family 11, subfamily C, polypeptide 1	Danio rerio	10-17
32222764-4	2020	In this study, we generated a zebrafish mutant of cyp11c1 (cyp11c1-/-) and utilized it to clarify the roles of 11-KT and cortisol in sexual development and reproduction.	11-ketotestosterone	111-116	cytochrome P450, family 11, subfamily C, polypeptide 1	Danio rerio	50-57
32001324-7	2020	It is proposed that the effects of hCG on ovarian development in previtellogenic eels could be indirect as a significant increase in plasma levels of 11-ketotestosterone (11-KT) was found in eels treated with hCG.	11-ketotestosterone	150-169	chorionic gonadotropin subunit beta 5	Homo sapiens	209-212
32001324-7	2020	It is proposed that the effects of hCG on ovarian development in previtellogenic eels could be indirect as a significant increase in plasma levels of 11-ketotestosterone (11-KT) was found in eels treated with hCG.	11-ketotestosterone	171-176	chorionic gonadotropin subunit beta 5	Homo sapiens	35-38
32001324-7	2020	It is proposed that the effects of hCG on ovarian development in previtellogenic eels could be indirect as a significant increase in plasma levels of 11-ketotestosterone (11-KT) was found in eels treated with hCG.	11-ketotestosterone	171-176	chorionic gonadotropin subunit beta 5	Homo sapiens	209-212
30825506-0	2019	The 11beta-hydroxysteroid dehydrogenase isoforms: pivotal catalytic activities yield potent C11-oxy C19 steroids with 11betaHSD2 favouring 11-ketotestosterone, 11-ketoandrostenedione and 11-ketoprogesterone biosynthesis.	11-ketotestosterone	139-158	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	118-128
31837141-8	2020	Loss of foxh1 resulted in significantly decreased Cyp19a1a and increased Cyp11b2 expression, consistent with significantly lower concentrations of serum estradiol-17beta (E2) and higher concentrations of 11-Ketotestosterone (11-KT).	11-ketotestosterone	204-223	forkhead box H1	Mus musculus	8-13
31837141-8	2020	Loss of foxh1 resulted in significantly decreased Cyp19a1a and increased Cyp11b2 expression, consistent with significantly lower concentrations of serum estradiol-17beta (E2) and higher concentrations of 11-Ketotestosterone (11-KT).	11-ketotestosterone	225-230	forkhead box H1	Mus musculus	8-13
31614207-9	2020	This system is also applicable to detect the conversion of 11-ketoandrostenedione to 11-ketotestosterone by HSD17B3.	11-ketotestosterone	85-104	hydroxysteroid 17-beta dehydrogenase 3	Homo sapiens	108-115
31039398-7	2019	In LNCaP cells expressing CYP17A1, 11alphaOHP4 and 11betaOHP4 were metabolised with negligible substrate, 4%, remaining after 48 h, while the steroid substrate 11beta,17alpha-dihydroxyprogesterone (21dF) was metabolised to C11-keto C19 steroids yielding 11-ketotestosterone.	11-ketotestosterone	254-273	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	26-33
30825506-4	2019	The apparent Km and Vmax values indicate the more prominent 11betaHSD2 activity towards 11beta-hydroxy androstenedione, 11beta-hydroxytestosterone and 11beta-hydroxyprogesterone in contrast to the 11betaHSD1 reduction of the C11-keto steroids, as was demonstrated in the LNCaP cell model in the production of 11-ketotestosterone and 11-ketodihydrotestosterone.	11-ketotestosterone	309-328	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	60-70
30825506-6	2019	In addition, 11betaHSD2 activity, catalysing 11-ketotestosterone biosynthesis, was shown to be key in the production of prostate specific antigen and in the progression of prostate cancer to castration resistant prostate cancer.	11-ketotestosterone	45-64	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	13-23
30825506-6	2019	In addition, 11betaHSD2 activity, catalysing 11-ketotestosterone biosynthesis, was shown to be key in the production of prostate specific antigen and in the progression of prostate cancer to castration resistant prostate cancer.	11-ketotestosterone	45-64	kallikrein related peptidase 3	Homo sapiens	120-145
30659898-4	2019	In the present study, we found that testosterone (T) and 11-ketotestosterone (11-KT) exhibited stimulatory effects on the expression of ep1 in the olfactory rosette in vivo and ex vivo.	11-ketotestosterone	57-76	prostaglandin E receptor 1	Homo sapiens	136-139
30659898-4	2019	In the present study, we found that testosterone (T) and 11-ketotestosterone (11-KT) exhibited stimulatory effects on the expression of ep1 in the olfactory rosette in vivo and ex vivo.	11-ketotestosterone	78-83	prostaglandin E receptor 1	Homo sapiens	136-139
29196300-6	2018	Further study shows that 11-ketotestosterone (11-KT) and 17beta-estradiol (E2) levels are significantly decreased in Zmettl3m/m , and defective gamete maturation is accompanied by decreased overall m6A modification levels and disrupted expression of genes critical for sex hormone synthesis and gonadotropin signaling in Zmettl3m/m Thus, our study provides the first in vivo evidence that loss of Mettl3 leads to failed gamete maturation and significantly reduced fertility in zebrafish.	11-ketotestosterone	25-44	methyltransferase like 3	Danio rerio	397-403
29931764-14	2018	A marked increase in plasma level of testosterone and 11-ketotestosterone was observed after hCG treatment in C. punctata.	11-ketotestosterone	54-73	chorionic gonadotropin subunit beta 5	Homo sapiens	93-96
27519632-2	2017	However, recent evidence has demonstrated that 11OHA4 is the precursor to the potent androgenic 11-oxygenated steroids, 11-ketotestosterone and 11-ketodihydrotestosterone, that bind and activate the human androgen receptor similarly to testosterone and DHT.	11-ketotestosterone	120-139	androgen receptor	Homo sapiens	205-222
28711705-5	2017	Expression of BMP15 showed positive correlation with seasonally changing testicular 17beta-estradiol but negatively with testicular testosterone and 11-ketotestosterone.	11-ketotestosterone	149-168	bone morphogenetic protein 15	Homo sapiens	14-19
28711705-6	2017	In vitro treatment of testis with recombinant human BMP15 enhanced the production of estradiol-17beta but concurrently suppressed the production of testosterone and 11-ketotestosterone in testis.	11-ketotestosterone	165-184	bone morphogenetic protein 15	Homo sapiens	52-57
28801581-0	2017	Bpifcl modulates kiss2 expression under the influence of 11-ketotestosterone in female zebrafish.	11-ketotestosterone	57-76	BPI fold containing family C, like	Danio rerio	0-6
28801581-6	2017	Exposure of female zebrafish to 11-ketotestosterone decreased bpifcl and kiss2 mRNA expression.	11-ketotestosterone	32-51	BPI fold containing family C, like	Danio rerio	62-68
28801581-6	2017	Exposure of female zebrafish to 11-ketotestosterone decreased bpifcl and kiss2 mRNA expression.	11-ketotestosterone	32-51	kisspeptin 2	Danio rerio	73-78
28213303-6	2017	Gene expression and plasma steroid level analyses demonstrated the suppressed mRNA levels of the key genes (such as gnrh3, fshbeta and lhbeta in brain and dmrt1, sf1, cyp17a1 and cyp11b2 in testis) in HPG axis and decreased 11-ketotestosterone (11-KT) levels in plasma.	11-ketotestosterone	224-243	gonadotropin-releasing hormone 3	Danio rerio	116-121
28213303-6	2017	Gene expression and plasma steroid level analyses demonstrated the suppressed mRNA levels of the key genes (such as gnrh3, fshbeta and lhbeta in brain and dmrt1, sf1, cyp17a1 and cyp11b2 in testis) in HPG axis and decreased 11-ketotestosterone (11-KT) levels in plasma.	11-ketotestosterone	224-243	follicle stimulating hormone subunit beta	Danio rerio	123-130
28213303-6	2017	Gene expression and plasma steroid level analyses demonstrated the suppressed mRNA levels of the key genes (such as gnrh3, fshbeta and lhbeta in brain and dmrt1, sf1, cyp17a1 and cyp11b2 in testis) in HPG axis and decreased 11-ketotestosterone (11-KT) levels in plasma.	11-ketotestosterone	224-243	luteinizing hormone subunit beta	Danio rerio	135-141
28213303-6	2017	Gene expression and plasma steroid level analyses demonstrated the suppressed mRNA levels of the key genes (such as gnrh3, fshbeta and lhbeta in brain and dmrt1, sf1, cyp17a1 and cyp11b2 in testis) in HPG axis and decreased 11-ketotestosterone (11-KT) levels in plasma.	11-ketotestosterone	224-243	cytochrome P450, family 11, subfamily C, polypeptide 1	Danio rerio	179-186
28838139-7	2017	Downregulation of Cyp19a1a and serum estradiol-17beta level, and upregulation of Cyp11b2 and serum 11-ketotestosterone level were observed in foxl2-/- XX fish.	11-ketotestosterone	99-118	forkhead box protein L2	Oreochromis niloticus	142-147
27345701-2	2017	Androstenedione (A4), 11beta-hydroxyandrostenedione (11OHA4) and 11beta-hydroxytestosterone (11OHT) are metabolised to potent androgen receptor (AR) agonists, dihydrotestosterone (DHT), 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT).	11-ketotestosterone	186-205	androgen receptor	Homo sapiens	126-143
26762230-5	2016	A significant increase in plasma E2 along with a decrease in plasma 11-keto testosterone was also observed in males, which was accompanied by up-regulation of CYP19a and inhibition of CYP11b transcription in the testis.	11-ketotestosterone	68-88	cytochrome P450, family 19, subfamily A, polypeptide 1a	Danio rerio	159-165
27497664-10	2016	The results showed that synthetic Kiss2 administration increased the expression of GnRH I, fshbeta and lhbeta mRNA in the brain and increased 17beta-estradiol (E2) and 11-ketotestosterone (11-KT) levels in the plasma.	11-ketotestosterone	168-187	kisspeptin 2	Oreochromis niloticus	34-39
26762230-5	2016	A significant increase in plasma E2 along with a decrease in plasma 11-keto testosterone was also observed in males, which was accompanied by up-regulation of CYP19a and inhibition of CYP11b transcription in the testis.	11-ketotestosterone	68-88	cytochrome P450, family 11, subfamily C, polypeptide 1	Danio rerio	184-190
27044511-7	2016	The reduction of Rspo1 expression by transcription activator-like (TAL) effector nuclease (TALEN) caused retarded ovarian development, the ectopic expression of male-dominant genes, and increased serum 11-ketotestosterone.	11-ketotestosterone	202-221	R-spondin-1	Oreochromis niloticus	17-22
27044511-8	2016	Intriguingly, a deficiency of Rspo1 in XY fish caused a delay in spermatogenesis, the inhibition of igf3 and amh expression and a reduction in serum 11-ketotestosterone.	11-ketotestosterone	149-168	R-spondin-1	Oreochromis niloticus	30-35
26308493-6	2015	The induction of sult2st3 and cyp2k22 by 11-ketotestosterone was repressed by co-exposure to the androgen receptor antagonist nilutamide supporting a potential androgen receptor mediated regulation.	11-ketotestosterone	41-60	sulfotransferase family 2, cytosolic sulfotransferase 3	Danio rerio	17-25
26308493-6	2015	The induction of sult2st3 and cyp2k22 by 11-ketotestosterone was repressed by co-exposure to the androgen receptor antagonist nilutamide supporting a potential androgen receptor mediated regulation.	11-ketotestosterone	41-60	cytochrome P450, family 2, subfamily K, polypeptide 22	Danio rerio	30-37
26308493-6	2015	The induction of sult2st3 and cyp2k22 by 11-ketotestosterone was repressed by co-exposure to the androgen receptor antagonist nilutamide supporting a potential androgen receptor mediated regulation.	11-ketotestosterone	41-60	androgen receptor	Danio rerio	97-114
26308493-6	2015	The induction of sult2st3 and cyp2k22 by 11-ketotestosterone was repressed by co-exposure to the androgen receptor antagonist nilutamide supporting a potential androgen receptor mediated regulation.	11-ketotestosterone	41-60	androgen receptor	Danio rerio	160-177
26308493-7	2015	Sensitivity (expressed as EC50 values) of sult2st3 and cyp2k22 gene expression induction after exposure to other steroidal hormones (11-ketotestosterone ~ testosterone > progesterone > cortisol > ethinylestradiol) correlated with their known binding affinities to zebrafish androgen receptor.	11-ketotestosterone	133-152	sulfotransferase family 2, cytosolic sulfotransferase 3	Danio rerio	42-50
26308493-7	2015	Sensitivity (expressed as EC50 values) of sult2st3 and cyp2k22 gene expression induction after exposure to other steroidal hormones (11-ketotestosterone ~ testosterone > progesterone > cortisol > ethinylestradiol) correlated with their known binding affinities to zebrafish androgen receptor.	11-ketotestosterone	133-152	cytochrome P450, family 2, subfamily K, polypeptide 22	Danio rerio	55-62
24105480-6	2013	In addition, disruption of Dmrt1 in XY fish resulted in increased foxl2 and cyp19a1a expression and serum estradiol-17beta and 11-ketotestosterone levels.	11-ketotestosterone	127-146	doublesex- and mab-3-related transcription factor 1	Oreochromis niloticus	27-32
25818047-5	2015	In vitro AR activation assay revealed that these three BFRs down-regulate 11-ketotestosterone (KT) mediated zAR activation.	11-ketotestosterone	74-93	dynein axonemal assembly factor 11	Danio rerio	9-11
25818047-5	2015	In vitro AR activation assay revealed that these three BFRs down-regulate 11-ketotestosterone (KT) mediated zAR activation.	11-ketotestosterone	74-93	dynein axonemal assembly factor 11	Danio rerio	108-111
25818047-5	2015	In vitro AR activation assay revealed that these three BFRs down-regulate 11-ketotestosterone (KT) mediated zAR activation.	11-ketotestosterone	95-97	dynein axonemal assembly factor 11	Danio rerio	9-11
25818047-5	2015	In vitro AR activation assay revealed that these three BFRs down-regulate 11-ketotestosterone (KT) mediated zAR activation.	11-ketotestosterone	95-97	dynein axonemal assembly factor 11	Danio rerio	108-111
22031714-6	2012	Increased Cyp11b expression in d-males was reflected by elevated 11-ketotestosterone plasma values.	11-ketotestosterone	65-84	cytochrome P450 11B, mitochondrial	Oreochromis niloticus	10-16
22796344-3	2012	In fish, 11beta-HSD2 has a dual role by inactivating glucocorticoids and generating the major androgen 11-ketotestosterone.	11-ketotestosterone	103-122	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	9-20
20713648-0	2010	Effects of reproductive stage and 11-ketotestosterone on LPL mRNA levels in the ovary of the shortfinned eel.	11-ketotestosterone	34-53	lipoprotein lipase	Homo sapiens	57-60
21310154-7	2011	The plasma levels of testosterone and 11-ketotestosterone also increased in response to hCG administration, likely as a result of the induction of the expression of steroidogenic enzymes by hCG.	11-ketotestosterone	38-57	chorionic gonadotropin subunit beta 5	Homo sapiens	88-91
21310154-7	2011	The plasma levels of testosterone and 11-ketotestosterone also increased in response to hCG administration, likely as a result of the induction of the expression of steroidogenic enzymes by hCG.	11-ketotestosterone	38-57	chorionic gonadotropin subunit beta 5	Homo sapiens	190-193
20713648-2	2010	Also, the effects of 11-ketotestosterone (11-KT) on LPL mRNA levels were investigated in vivo and in vitro.	11-ketotestosterone	21-40	lipoprotein lipase	Homo sapiens	52-55
20584991-6	2010	Furthermore, treatments of human chorionic gonadotropin and 11-ketotestosterone in vitro up-regulated sox9a mRNA levels in the testicular slices at 12 and 24 h time points, suggesting that gonadotropins might stimulate sox9 expression.	11-ketotestosterone	60-79	SRY-box transcription factor 9	Homo sapiens	102-106
20219674-2	2010	The open reading frame of 11beta-HSD2 was then transfected to COS-7 cells, which converted 11beta-hydroxytestosterone (11-OHT) to 11-ketotestosterone (11-KT).	11-ketotestosterone	130-149	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	26-37
20219674-2	2010	The open reading frame of 11beta-HSD2 was then transfected to COS-7 cells, which converted 11beta-hydroxytestosterone (11-OHT) to 11-ketotestosterone (11-KT).	11-ketotestosterone	151-156	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	26-37
20219674-7	2010	Rate of conversion of 11-OHT to 11-KT by testicular microsomes during different testicular phases and after hCG administration corroborated well with the expression of 11beta-HSD2.	11-ketotestosterone	32-37	chorionic gonadotropin subunit beta 5	Homo sapiens	108-111
20219674-7	2010	Rate of conversion of 11-OHT to 11-KT by testicular microsomes during different testicular phases and after hCG administration corroborated well with the expression of 11beta-HSD2.	11-ketotestosterone	32-37	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	168-179
19494047-4	2009	Time-resolved fluorescent immunoassay showed that arsenic suppressed hCG-induced synthesis of 11-ketotestosterone (11-KT) in testicular fragments incubated with 0.0001-100 microM arsenic and hCG for 18 h. A 0.1 microM (7 microg/l) dose of arsenic which is lower than the World Health Organization drinking water quality guideline of 10 microg/l most effectively reduced 11-KT production.	11-ketotestosterone	94-113	chorionic gonadotropin subunit beta 5	Homo sapiens	69-72
19494047-4	2009	Time-resolved fluorescent immunoassay showed that arsenic suppressed hCG-induced synthesis of 11-ketotestosterone (11-KT) in testicular fragments incubated with 0.0001-100 microM arsenic and hCG for 18 h. A 0.1 microM (7 microg/l) dose of arsenic which is lower than the World Health Organization drinking water quality guideline of 10 microg/l most effectively reduced 11-KT production.	11-ketotestosterone	115-120	chorionic gonadotropin subunit beta 5	Homo sapiens	69-72
19494047-4	2009	Time-resolved fluorescent immunoassay showed that arsenic suppressed hCG-induced synthesis of 11-ketotestosterone (11-KT) in testicular fragments incubated with 0.0001-100 microM arsenic and hCG for 18 h. A 0.1 microM (7 microg/l) dose of arsenic which is lower than the World Health Organization drinking water quality guideline of 10 microg/l most effectively reduced 11-KT production.	11-ketotestosterone	115-120	chorionic gonadotropin subunit beta 5	Homo sapiens	191-194
19494047-4	2009	Time-resolved fluorescent immunoassay showed that arsenic suppressed hCG-induced synthesis of 11-ketotestosterone (11-KT) in testicular fragments incubated with 0.0001-100 microM arsenic and hCG for 18 h. A 0.1 microM (7 microg/l) dose of arsenic which is lower than the World Health Organization drinking water quality guideline of 10 microg/l most effectively reduced 11-KT production.	11-ketotestosterone	370-375	chorionic gonadotropin subunit beta 5	Homo sapiens	69-72
19494047-4	2009	Time-resolved fluorescent immunoassay showed that arsenic suppressed hCG-induced synthesis of 11-ketotestosterone (11-KT) in testicular fragments incubated with 0.0001-100 microM arsenic and hCG for 18 h. A 0.1 microM (7 microg/l) dose of arsenic which is lower than the World Health Organization drinking water quality guideline of 10 microg/l most effectively reduced 11-KT production.	11-ketotestosterone	370-375	chorionic gonadotropin subunit beta 5	Homo sapiens	191-194
20654577-1	2010	11Beta-hydroxysteroid dehydrogenase-type 2 (11beta-HSD2) regulates the local concentration of cortisol that can activate the glucocorticoid receptor and mineralocorticoid receptor, as well as the concentration of 11-keto-testosterone, the active androgen in fish.	11-ketotestosterone	213-233	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	44-55