PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28435449-3	2017	In this study, we functionalized the chitosan/hydroxyapatite (CS/HA) biomimetic composite scaffold for controlled delivery of BMP2-derived peptide (P24) by the chemical grafting modification technique: firstly, P24 was conjugated with a thiolated chitosan, chitosan-4-thiobutylamidine (CS-TBA); secondly, the resultant CS-P24 was then combined with HA to prepare CS-P24/HA scaffolds.	ha	65-67	bone morphogenetic protein 2	Rattus norvegicus	126-130
29147489-8	2017	In vivo, PRP-enriched hAdMSCs seeded on HA/TCP granules induced considerable bone formation in osseous defects (P<0.05).	ha	40-42	complement component 4 binding protein alpha	Homo sapiens	9-12
27552029-2	2016	We investigated the interaction of a model protein lysozyme (Lys) with poly(L-lysine)/hyaluronic acid (PLL/HA) multilayer films.	ha	107-109	lysozyme	Homo sapiens	51-59
27772704-6	2017	The results of protein adsorption and cellular experiments showed that compared to the single TiO2 surface, the HA/TiO2 surface allowed more adsorption of serum proteins and further enhanced the alkaline phosphatase (ALP) activity of MC3T3-E1 osteoblasts.	ha	112-114	alkaline phosphatase, placental	Homo sapiens	195-215
27772704-6	2017	The results of protein adsorption and cellular experiments showed that compared to the single TiO2 surface, the HA/TiO2 surface allowed more adsorption of serum proteins and further enhanced the alkaline phosphatase (ALP) activity of MC3T3-E1 osteoblasts.	ha	112-114	alkaline phosphatase, placental	Homo sapiens	217-220
26882868-1	2016	PURPOSE: Endoscopic dextranomer/hyaluronic acid copolymer (Dx/HA) injection is a safe and efficacious treatment option for vesicoureteral reflux (VUR) in children.	ha	62-64	VUR	Homo sapiens	146-149
27555781-9	2016	Using fluorescent dyes and flow cytometry analysis, HA/ZnO nanocomposite caused G2/M cell cycle arrest and stimulated apoptosis-related increase in caspase-3 and -7 activities of the HL-60 cells.	ha	52-54	caspase 3	Homo sapiens	148-164
27064169-4	2016	Detailed mechanistic studies show that while the complexes retain the monodentate X ligand upon electrochemical reduction to Co(II) species in MeCN solution, in aqueous solution, upon reduction by ascorbate (photocatalytic conditions), [Co(II)(N4Py)(HA)](+) is formed in all cases and is the precursor to the Co(I) species which presumably reacts with a proton.	ha	250-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	125-131
27064169-4	2016	Detailed mechanistic studies show that while the complexes retain the monodentate X ligand upon electrochemical reduction to Co(II) species in MeCN solution, in aqueous solution, upon reduction by ascorbate (photocatalytic conditions), [Co(II)(N4Py)(HA)](+) is formed in all cases and is the precursor to the Co(I) species which presumably reacts with a proton.	ha	250-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	237-243
26900622-2	2016	We have recently developed a CD44 receptor targeted, hyaluronic acid-adamantamethamidyl based pendant polymer system (HA-Ad), capable of forming complexes with cationic beta-cyclodextrins (CD-PEI(+)) and pDNA.	ha	118-120	CD44 molecule (Indian blood group)	Homo sapiens	29-33
26487981-7	2015	At the gene expression level, HA/TCP coating significantly increased the expression of ALP and COLI on day 4.	ha	30-32	ATHS	Homo sapiens	87-90
26258264-5	2015	In vivo and ex vivo bioimaging of the ZW800-1-labeled HA-IFNalpha conjugate directly showed real-time biodistribution and clearance of the conjugate that are consistent with the biological behaviors analyzed by an enzyme-linked immunosorbent assay.	ha	54-56	interferon alpha 1	Homo sapiens	57-65
26112373-8	2015	The hESCs cultured in HA-Tyr hydrogels showed high expression of CD44 and pluripotency markers.	ha	22-24	CD44 molecule (Indian blood group)	Homo sapiens	65-69
26690867-7	2015	We also demonstrated reduction of Vimentin with DOX-HA-SPION which is significantly less than both control and DOX.	ha	52-54	vimentin	Homo sapiens	34-42
24737694-9	2015	In conclusion, the results of this study demonstrated that the bone forming capacity of HA/TCP scaffolds with pre-adsorbed BMP-2 was equal at different ectopic implantation sites.	ha	88-90	bone morphogenetic protein 2	Homo sapiens	123-128
25413254-11	2015	Compared with C-HAS-treated cells, NADPH oxidase 4 mRNA expression increased in cells after DM2-HSA treatment.	ha	16-19	NADPH oxidase 4	Homo sapiens	35-50
25413254-11	2015	Compared with C-HAS-treated cells, NADPH oxidase 4 mRNA expression increased in cells after DM2-HSA treatment.	ha	16-19	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	92-95
25687053-1	2015	OBJECTIVE: This study was to investigate the effect of has-miR-150 on the proliferation and apoptosis in human acute T lymphocytic leukemia (T-ALL) cell line Jurkat, and explore its mechanism.	ha	55-58	microRNA 150	Homo sapiens	59-66
25322665-3	2015	The long-term culture of BM-MSCs with HA/TCP induced an osteoblast-like phenotype with upregulation of OSTERIX and OSTEOCALCIN, similar to what was obtained with dexamethasone and, to a higher extent, with bone morphogenetic protein 4 (BMP-4) treatment.	ha	38-40	Sp7 transcription factor	Homo sapiens	103-110
25322665-3	2015	The long-term culture of BM-MSCs with HA/TCP induced an osteoblast-like phenotype with upregulation of OSTERIX and OSTEOCALCIN, similar to what was obtained with dexamethasone and, to a higher extent, with bone morphogenetic protein 4 (BMP-4) treatment.	ha	38-40	bone gamma-carboxyglutamate protein	Homo sapiens	115-126
25322665-3	2015	The long-term culture of BM-MSCs with HA/TCP induced an osteoblast-like phenotype with upregulation of OSTERIX and OSTEOCALCIN, similar to what was obtained with dexamethasone and, to a higher extent, with bone morphogenetic protein 4 (BMP-4) treatment.	ha	38-40	bone morphogenetic protein 4	Homo sapiens	206-234
25322665-3	2015	The long-term culture of BM-MSCs with HA/TCP induced an osteoblast-like phenotype with upregulation of OSTERIX and OSTEOCALCIN, similar to what was obtained with dexamethasone and, to a higher extent, with bone morphogenetic protein 4 (BMP-4) treatment.	ha	38-40	bone morphogenetic protein 4	Homo sapiens	236-241
25322665-6	2015	Since COX-2 is significantly involved in bone healing, its induction by HA/TCP could also contribute to the therapeutic activity of MSCs for bone tissue engineering.	ha	72-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	6-11
24912815-9	2014	Our study explicitly demonstrates that CS/HA composite material improves diabetes-induced impaired osteointegration of Ti via the reactivation of Wnt/beta-catenin pathway and provides a target point for biomaterial modification to attain better clinical performance in diabetic patients.	ha	42-44	Wnt family member 3A	Homo sapiens	146-149
24842660-11	2014	Compared with Taxotere , Chol-Suc-HA-DTX NPs displayed remarkably higher cytotoxicity to CD44-positive cancer cells (MCF-7, 4T1, A549 cells).	ha	34-36	CD44 molecule (Indian blood group)	Homo sapiens	89-93
24912815-9	2014	Our study explicitly demonstrates that CS/HA composite material improves diabetes-induced impaired osteointegration of Ti via the reactivation of Wnt/beta-catenin pathway and provides a target point for biomaterial modification to attain better clinical performance in diabetic patients.	ha	42-44	catenin beta 1	Homo sapiens	150-162
24858301-4	2014	RESULTS: HA/sorbitol prevented IL-1beta-induced oxidative stress, as measured by reactive oxygen species, p47-NADPH oxidase phosphorylation, 4-hydroxynonenal (HNE) production and HNE-metabolizing glutathione-S-transferase A4-4 expression.	ha	9-11	interleukin 1 beta	Homo sapiens	31-39
24858301-4	2014	RESULTS: HA/sorbitol prevented IL-1beta-induced oxidative stress, as measured by reactive oxygen species, p47-NADPH oxidase phosphorylation, 4-hydroxynonenal (HNE) production and HNE-metabolizing glutathione-S-transferase A4-4 expression.	ha	9-11	pleckstrin	Homo sapiens	106-109
23790635-7	2013	Finally, blockade of Rho-kinase activity with Y27632 or protein kinase-Ngamma activity with Ro31-8220 significantly decreased the HA (HAS or HAL)-mediated changes in epidermal function in aged mouse skin.	ha	134-137	histidine ammonia lyase	Mus musculus	130-132
24858301-7	2014	Examination of signaling pathway components disclosed that HA/sorbitol prevented IL-1beta-induced p38 mitogen-activated protein kinase and nuclear factor-kappa B activation, but not that of extracellular signal-regulated kinases 1 and 2.	ha	59-61	interleukin 1 beta	Homo sapiens	81-89
24033386-8	2013	PAFR protein expression was significantly downregulated in both cell types by both Y-27632 and HA-1077, with comparable profiles.	ha	95-97	platelet activating factor receptor	Homo sapiens	0-4
23910342-1	2013	The novel interpenetrating (HA+beta-TCP)/MgCa composites were fabricated by infiltrating MgCa alloy into porous HA+beta-TCP using suction casting technique.	ha	28-31	attractin	Homo sapiens	89-93
24144758-7	2013	SCAP with HA/TCP could regenerate pulp-dentin complex-like tissue in nude mice.	ha	10-12	SREBF chaperone	Mus musculus	0-4
23853490-1	2013	We aimed to investigate the clinical value of persistent but downgraded vesicoureteral reflux (VUR) after dextranomer/hyaluronic acid (Dx/HA) injection in children.	ha	138-140	VUR	Homo sapiens	95-98
23384419-4	2013	By confocal microscopy and flow cytometry analyses, we demonstrate that the cellular uptake into a highly CD44-expressing pancreatic adenocarcinoma cell line is higher with HA-conjugated (12kDa>4.8kDa) than non-conjugated liposomes.	ha	173-175	CD44 molecule (Indian blood group)	Homo sapiens	106-110
25428093-7	2013	In addition, the sintering tests show that the Se-HA powders with the Se/P ratio of 0.1 have thermal stability at 900  C for 2 h; hence they have great potential in the fabrication of bone repair scaffolds.	ha	50-52	membrane metalloendopeptidase like 1	Homo sapiens	70-74
23328125-9	2013	Histological studies confirmed that tumor tissues in mice treated with IFN-alpha2a-incorporated HA-Tyr hydrogels showed lower cell density, with more apoptotic and less proliferating cells compared with tissues treated with an IFN-alpha2a solution.	ha	96-98	interferon alpha 2	Mus musculus	227-237
23328125-3	2013	IFN-alpha2a-incorporated HA-Tyr hydrogels of varying stiffness were formed by changing the H2O2 concentration.	ha	25-27	interferon alpha 2	Mus musculus	0-10
23328125-8	2013	The tumor regression study revealed that IFN-alpha2a-incorporated HA-Tyr hydrogels effectively inhibited tumor growth, while the injection of an IFN-alpha2a solution did not demonstrate antitumor efficacy.	ha	66-68	interferon alpha 2	Mus musculus	41-51
23328125-9	2013	Histological studies confirmed that tumor tissues in mice treated with IFN-alpha2a-incorporated HA-Tyr hydrogels showed lower cell density, with more apoptotic and less proliferating cells compared with tissues treated with an IFN-alpha2a solution.	ha	96-98	interferon alpha 2	Mus musculus	71-81
23135410-0	2013	Evaluation of collagen/heparin coated TCP/HA granules for long-term delivery of BMP-2.	ha	42-44	bone morphogenetic protein 2	Homo sapiens	80-85
22522300-0	2012	Spectroscopic analyses on sonocatalytic damage to bovine serum albumin (BSA) induced by ZnO/hydroxylapatite (ZnO/HA) composite under ultrasonic irradiation.	ha	113-115	albumin	Homo sapiens	57-70
22811486-9	2012	Immunoblot analysis demonstrated activation of Rho-kinase in glomeruli of antipodocyte serum-treated mice, which was prevented by HA-1077.	ha	130-132	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	47-57
22522300-2	2012	The sonocatalytic activities of ZnO/HA composite was carried out through the damage of bovine serum albumin (BSA) in aqueous solution.	ha	36-38	albumin	Homo sapiens	94-107
22350800-6	2012	RESULTS: Polymer conjugates bearing HA oligomers at the size of 10 oligosaccharides and above (HA(10-14)) bind actively and profoundly to CD44-overexpressing ovarian cancer cells (SK-OV-3) and internalize to the greatest extent relative to HA-polymer conjugates of 8 oligomers and below (HA(4-8)).	ha	36-38	CD44 molecule (Indian blood group)	Homo sapiens	138-142
21593487-6	2011	The survival compounds Y-27632, HA-1077, and H-8 all strongly inhibit the kinases ROCK and PRK2, highlighting the important role of these kinases in EC cell survival.	ha	32-34	protein kinase N2	Homo sapiens	91-95
21318627-7	2011	In conclusion, by presenting strong osteogenic commitment of hMSCs in vitro, the PCL/HA-AL microspheres have the potential to be used as an injectable vehicle for local therapy of bone defect.	ha	85-87	PHD finger protein 1	Homo sapiens	81-84
21277020-3	2011	In this work, anti-Flt1 peptide (GGNQWFI) was chemically conjugated to tetra-n-butyl ammonium modified hyaluronate (HA-TBA) via amide bond formation in dimethyl sulfoxide (DMSO) using benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP).	ha	116-118	Fms related receptor tyrosine kinase 1	Rattus norvegicus	19-23
20041154-8	2009	All of these enzymes reacted with HA-tagged vinyl sulfone derivatives of SUMO-2 (HA-SU2-VS) but not SUMO-1 (HA-SU1-VS), suggesting that they act primarily on SUMO-2 and -3.	ha	34-36	small ubiquitin-like modifier 2 S homeolog	Xenopus laevis	73-79
21239738-3	2011	In this study, we investigated the role of CD44 in o-HA-induced proliferation and tube formation of human umbilical vein endothelial cells (HUVECs) and explored the molecular mechanisms underlying the angiogenesis process.	ha	53-55	CD44 molecule (Indian blood group)	Homo sapiens	43-47
20883178-3	2010	This work describes the formation and characterization of hyaluronic acid-chitosan (HA/CS) nanoparticles for the delivery of two pro-angiogenic growth factors: vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF-BB).	ha	84-86	vascular endothelial growth factor A	Homo sapiens	160-194
20883178-8	2010	Moreover, HA/CS nanoparticles were able to entrap efficiently both growth factors, reaching association values of 94% and 54% for VEGF and PDGF, respectively.	ha	10-12	vascular endothelial growth factor A	Homo sapiens	130-134
20368325-1	2010	OBJECTIVE: Published success rates of dextranomer/hyaluronic acid (Dx/HA) injection for pediatric vesicoureteral reflux (VUR) vary widely.	ha	70-72	VUR	Homo sapiens	121-124
20041154-8	2009	All of these enzymes reacted with HA-tagged vinyl sulfone derivatives of SUMO-2 (HA-SU2-VS) but not SUMO-1 (HA-SU1-VS), suggesting that they act primarily on SUMO-2 and -3.	ha	34-36	small ubiquitin-like modifier 2 S homeolog	Xenopus laevis	158-171
20041154-8	2009	All of these enzymes reacted with HA-tagged vinyl sulfone derivatives of SUMO-2 (HA-SU2-VS) but not SUMO-1 (HA-SU1-VS), suggesting that they act primarily on SUMO-2 and -3.	ha	81-83	small ubiquitin-like modifier 2 S homeolog	Xenopus laevis	73-79
20041154-8	2009	All of these enzymes reacted with HA-tagged vinyl sulfone derivatives of SUMO-2 (HA-SU2-VS) but not SUMO-1 (HA-SU1-VS), suggesting that they act primarily on SUMO-2 and -3.	ha	81-83	small ubiquitin-like modifier 2 S homeolog	Xenopus laevis	158-171
19567779-9	2009	The ability of morphine withdrawal to activate ERK that phosphorylates TH at Ser31 was reduced by HA-1004.	ha	98-100	Eph receptor B1	Rattus norvegicus	47-50
19567779-9	2009	The ability of morphine withdrawal to activate ERK that phosphorylates TH at Ser31 was reduced by HA-1004.	ha	98-100	tyrosine hydroxylase	Rattus norvegicus	71-73
16629647-5	2006	A strong relationship was found between HA/ABT and AST/ABT (r=0.755 P<0.0001).	ha	40-42	solute carrier family 17 member 5	Homo sapiens	51-54
19024309-1	2008	OBJECTIVE: Osteoblasts behaviors were investigated when cultured in the presence of silver-hydroxyapatite/titania nanoparticles (nAg-HA/TiO2) in vitro.	ha	133-135	sodium voltage-gated channel alpha subunit 7	Rattus norvegicus	129-132
18991642-6	2008	This augmented responsiveness to methacholine involves the phosphorylation of myosin phosphatase targeting protein 1 (MYPT1) via Rho-kinase, however, it is attenuated by pre-treatment with Rho-kinase inhibitors such as Y-27632 and HA-1077.	ha	231-233	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	78-116
18991642-6	2008	This augmented responsiveness to methacholine involves the phosphorylation of myosin phosphatase targeting protein 1 (MYPT1) via Rho-kinase, however, it is attenuated by pre-treatment with Rho-kinase inhibitors such as Y-27632 and HA-1077.	ha	231-233	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	118-123
17761835-8	2007	Furthermore, wortmannin abrogated the reduction of serum ALT level by HA-1077 in rats with acute liver injury induced by CCl4, suggesting that the activation of PI3-kinase/Akt pathway may be involved in the hepatocyte-protective effect by Rho-kinase inhibitor in vivo.	ha	70-72	C-C motif chemokine ligand 4	Rattus norvegicus	121-125
17761835-8	2007	Furthermore, wortmannin abrogated the reduction of serum ALT level by HA-1077 in rats with acute liver injury induced by CCl4, suggesting that the activation of PI3-kinase/Akt pathway may be involved in the hepatocyte-protective effect by Rho-kinase inhibitor in vivo.	ha	70-72	AKT serine/threonine kinase 1	Rattus norvegicus	172-175
16471577-7	2006	The reaction occurring at the second peak is a concerted proton and electron transfer (CPET) in which the electron is transferred to superoxide and a proton is transferred from HA to the superoxide, forming HO2- and A- in a concerted process.	ha	177-179	heme oxygenase 2	Homo sapiens	207-210
16359211-3	2005	In this study, we tried to determine the efficacy of dextranomer/hyaluronic acid copolymer (Dx/HA) injection for the treatment of VUR in renal-transplant candidates.	ha	95-97	VUR	Homo sapiens	130-133
15569838-4	2004	The effect of thrombin was prevented by C3 exoenzyme or the HMG-CoA reductase inhibitor fluvastatin, which inhibit RhoA, or by the ROCK inhibitors Y-27632 and HA-1077.	ha	159-161	coagulation factor II, thrombin	Homo sapiens	14-22
14501658-1	2003	PURPOSE: Endoscopic injection of dextranomer/hyaluronic acid (Dx/HA) copolymer is an increasingly established treatment for primary vesicoureteral reflux (VUR) in children.	ha	65-67	VUR	Homo sapiens	155-158
14500131-5	2004	ET-1 (0.1 nM) alone did not produce any significant contraction, but it markedly potentiated the magnitude (223% of control) and rate (149% of control) of contraction in response to OxyHb, which was attenuated by the inhibitors of Rho kinase Y-27632 and HA-1077.	ha	254-256	endothelin-1	Oryctolagus cuniculus	0-4
15457544-8	2004	Spam1 on the surface of caudal sperm was shown to mediate the increase in acrosome reactions induced by the synergistic effects of HA and progesterone, as confirmed in sperm from the Rb(6.16) translocation-bearing mice which are Spam1 mutants.	ha	131-133	sperm adhesion molecule 1	Mus musculus	0-5
12603161-7	2003	When NEA and methyl pyruvate are coadsorbed in the presence of H(a), STM reveals entities that could correspond to a 1:1 docking complex between the prochiral reactant and the chiral modifier.	ha	63-67	sulfotransferase family 1A member 3	Homo sapiens	69-72
12761303-8	2003	Biochemical, BIAcore and computer modeling analyses demonstrated that HA-A bound selectively to the N-terminal 8 kDa DNA template-binding domain of DNA polymerase beta, and HA-A inhibited the ssDNA binding activity.	ha	70-72	DNA polymerase beta	Homo sapiens	148-167
12562894-2	2003	To check the recent suggestion that Rho kinase is involved in the TRH-induced r-ERG current suppression, the hormonal effects were studied in cells pretreated with the Rho kinase inhibitors Y-27632 and HA-1077.	ha	202-204	thyrotropin releasing hormone	Rattus norvegicus	66-69
12562894-5	2003	Further experiments indicated that the effect of HA-1077 correlated with its ability to inhibit protein kinase C (PKC).	ha	49-51	protein kinase C, gamma	Rattus norvegicus	96-112
12562894-5	2003	Further experiments indicated that the effect of HA-1077 correlated with its ability to inhibit protein kinase C (PKC).	ha	49-51	protein kinase C, gamma	Rattus norvegicus	114-117
12023886-8	2002	On the other hand, the ROK inhibitors Y-27632 and HA-1077 abolished the tonic component of K+-induced contraction, and slightly reduced the phasic component.	ha	50-52	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	23-26
12506136-6	2003	ROK inhibition with Y-27632 or HA-1077, but not protein kinase C inhibition with Ro 31-8220, blunted ET B-induced vasoconstriction.	ha	31-33	endothelin receptor type B	Rattus norvegicus	101-105
12067241-5	2002	In contrast, two other Rho-kinase inhibitors, HA-1077 at 30 microM and Y-27632 at 10-30 microM, inhibited the phosphorylation of MARCKS in the cells stimulated by LPA and PDBu.	ha	46-48	myristoylated alanine rich protein kinase C substrate	Homo sapiens	129-135
11865276-1	2002	OBJECTIVES: Dextranomer/hyaluronic acid (Dx/HA) copolymer has favorable properties for endoscopic treatment of vesico-ureteral reflux (VUR).	ha	44-46	VUR	Homo sapiens	111-133
11865276-1	2002	OBJECTIVES: Dextranomer/hyaluronic acid (Dx/HA) copolymer has favorable properties for endoscopic treatment of vesico-ureteral reflux (VUR).	ha	44-46	VUR	Homo sapiens	135-138
11024216-1	2000	OBJECTIVE: To identify the receptor of hyaluronic acid mediated motility (RHAMM), expression pattern(s) in the gastric mucosa with various lesions and to elucidate the effect of hyaluronic acid(HA) on in vitro RHAMM expression.	ha	75-77	hyaluronan mediated motility receptor	Homo sapiens	27-72
10796042-2	2000	METHODS: The effect of diclofenac/HA on angiogenesis was determined by choriocapillary endothelial cells on Matrigel stimulated by vascular endothelial growth factor (VEGF).	ha	34-36	vascular endothelial growth factor A	Oryctolagus cuniculus	131-165
10806200-3	2000	Geldanamycin (GA) and herbimycin (HA), specific inhibitors of the cytosolic chaperone HSP 90 and its endoplasmic reticulum homologue GRP 94, were shown to accelerate degradation of the EGF-R and of its homologue p185(c-)(erbB-2).	ha	34-36	heat shock protein 90 beta family member 1	Homo sapiens	133-139
10806200-3	2000	Geldanamycin (GA) and herbimycin (HA), specific inhibitors of the cytosolic chaperone HSP 90 and its endoplasmic reticulum homologue GRP 94, were shown to accelerate degradation of the EGF-R and of its homologue p185(c-)(erbB-2).	ha	34-36	epidermal growth factor receptor	Homo sapiens	185-190
10806200-3	2000	Geldanamycin (GA) and herbimycin (HA), specific inhibitors of the cytosolic chaperone HSP 90 and its endoplasmic reticulum homologue GRP 94, were shown to accelerate degradation of the EGF-R and of its homologue p185(c-)(erbB-2).	ha	34-36	erb-b2 receptor tyrosine kinase 2	Homo sapiens	212-227
10796042-2	2000	METHODS: The effect of diclofenac/HA on angiogenesis was determined by choriocapillary endothelial cells on Matrigel stimulated by vascular endothelial growth factor (VEGF).	ha	34-36	vascular endothelial growth factor A	Oryctolagus cuniculus	167-171
10796042-7	2000	RESULTS: Diclofenac/HA, 180, 90 microg/ml, inhibited tube formation to 24% and 55% of the standard group (Media Ham"s F12 plus 5% fetal calf serum and 50 ng/ml VEGF) respectively (P<0.01).	ha	20-22	vascular endothelial growth factor A	Oryctolagus cuniculus	160-164
11043824-7	2000	Here, we report the first evidence of post-translational modification of c-Myb by ubiquitin in vivo using HA-labeled ubiquitin.	ha	106-108	MYB proto-oncogene, transcription factor	Homo sapiens	73-78
2598315-2	1989	However, this accelerative activity was significantly lower than that induced by heparin with high affinity for AT III (HA-heparin), probably due to the formation of the binary complexes of HA-heparin-AT III as well as that composed of thrombin and heparin with low affinity for AT III (LA-heparin).	ha	120-122	serpin family C member 1	Homo sapiens	112-118
8929814-6	1996	The effects of anisoosmolarity on PEPCK mRNA levels in H4IIE cells were largely abolished in the presence of the protein kinase inhibitors H-7, H-89 and HA-1004.	ha	153-155	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	34-39
7488743-2	1995	Microdensitometric analyses revealed that, in the absence of ionophore-mediated calcium influx, PHF-1 levels were reduced by approximately half in cultures treated with HA-1004 or W-7, but were not reduced by H-7.	ha	169-171	PHD finger protein 1	Homo sapiens	96-101
10375657-7	1999	On the other hand, the rCBF response abolished by 1000 microg/kg of (+)-3-amino-1-hydroxy-2-pyrrolidone (HA-966), an antagonist of the glycine modulatory site on the N-methyl-d-aspartate (NMDA) receptors, was not restored by FK960 (1000 microg/kg, i.v.).	ha	105-107	CCAAT/enhancer binding protein zeta	Rattus norvegicus	23-27
9762012-8	1998	GH primary transcripts were increased by FK506, and the effects were blocked by H-89 and HA-1004.	ha	89-91	gonadotropin releasing hormone receptor	Rattus norvegicus	0-2
9562572-7	1998	Manipulation of joint cavity development, using oligosaccharides of HA, disrupted joint formation and was associated with decreases in CD44 and actin filament expression as well as decreased hyaluronan synthetic capability.	ha	68-70	CD44 molecule (Indian blood group)	Gallus gallus	135-139
8982703-7	1996	These findings suggest that 90-kDa S6 kinase is unrelated or insufficient to mediate activation of glycogen synthase and that unidentified pathway(s) sensitive to H-7 or HA-1077 would be involved in the activation of glycogen synthase by insulin or EGF in 3Y1 fibroblasts.	ha	170-172	insulin	Homo sapiens	238-245
8982703-7	1996	These findings suggest that 90-kDa S6 kinase is unrelated or insufficient to mediate activation of glycogen synthase and that unidentified pathway(s) sensitive to H-7 or HA-1077 would be involved in the activation of glycogen synthase by insulin or EGF in 3Y1 fibroblasts.	ha	170-172	epidermal growth factor	Homo sapiens	249-252
2598315-2	1989	However, this accelerative activity was significantly lower than that induced by heparin with high affinity for AT III (HA-heparin), probably due to the formation of the binary complexes of HA-heparin-AT III as well as that composed of thrombin and heparin with low affinity for AT III (LA-heparin).	ha	120-122	serpin family C member 1	Homo sapiens	201-207
2598315-2	1989	However, this accelerative activity was significantly lower than that induced by heparin with high affinity for AT III (HA-heparin), probably due to the formation of the binary complexes of HA-heparin-AT III as well as that composed of thrombin and heparin with low affinity for AT III (LA-heparin).	ha	120-122	coagulation factor II, thrombin	Homo sapiens	236-244
2598315-2	1989	However, this accelerative activity was significantly lower than that induced by heparin with high affinity for AT III (HA-heparin), probably due to the formation of the binary complexes of HA-heparin-AT III as well as that composed of thrombin and heparin with low affinity for AT III (LA-heparin).	ha	120-122	serpin family C member 1	Homo sapiens	201-207
31612121-1	2019	Purpose: Endoscopic dextranomer/hyaluronic acid (Dx/HA) injection is a common treatment for vesicoureteral reflux (VUR) with excellent reported short-term clinical success rates.	ha	52-54	VUR	Homo sapiens	115-118
2955213-5	1987	The dechlorinated analogues, HA-100 and HA-142, markedly decreased the affinity for MLC-kinase, suggesting that the inhibitory effect of isoquinolinesulfonamide derivatives depends upon hydrophobicity of the compounds.	ha	29-31	myosin light chain kinase	Homo sapiens	84-94
31498349-6	2019	The cyclic voltammograms obtained with H2AA in solution at Au/[CuII(4-mbpy-Bz-SMe)2]2+ as the working electrode showed a one-electron reaction leading to the ascorbyl radical (HA ), which was detected by EPR.	ha	176-178	H2A clustered histone 8	Homo sapiens	39-43
32151083-0	2020	Exercise Promotes the Osteoinduction of HA/beta-TCP Biomaterials via the Wnt Signaling Pathway.	ha	40-42	wingless-type MMTV integration site family, member 1	Mus musculus	73-76
30802715-11	2019	RESULTS: Ha-EtOAc inhibited the LPS-induced production of NO and decreased the release of TNF-alpha, IL-6 and IL-1beta in RAW264.7 cells in a dose-dependent manner.	ha	9-11	tumor necrosis factor	Mus musculus	90-99
31229855-3	2019	Herein, we constructed a positive feedback nanoamplifier by encapsulating glucose oxidase (GOx) in the ferric ions contained metal organic framework (MIL-100), and coating the nanoparticles with polydopamine modified hyaluronic acid (HA-PDA).	ha	234-236	hydroxyacid oxidase 1, liver	Mus musculus	91-94
30802715-11	2019	RESULTS: Ha-EtOAc inhibited the LPS-induced production of NO and decreased the release of TNF-alpha, IL-6 and IL-1beta in RAW264.7 cells in a dose-dependent manner.	ha	9-11	interleukin 6	Mus musculus	101-105
30802715-11	2019	RESULTS: Ha-EtOAc inhibited the LPS-induced production of NO and decreased the release of TNF-alpha, IL-6 and IL-1beta in RAW264.7 cells in a dose-dependent manner.	ha	9-11	interleukin 1 beta	Mus musculus	110-118
30403471-4	2018	Polydopamine-modified hyaluronic acid (HA-PDA) is coated on the MIL-100 surface to construct engineering MOF nanoparticles (MCH NPs).	ha	39-41	modifier of chinchilla	Mus musculus	124-127
29675477-2	2018	Dextranomer/hyaluronic acid (Dx/HA) is the most commonly used bulking agent for the treatment of VUR.	ha	32-34	VUR	Homo sapiens	97-100
30243219-3	2018	Mucin adhesion study showed that the amount of mucin adhered to NAC-HA-PTX micelles was 1.98-fold greater than that of hyaluronic acid-paclitaxel (HA-PTX) micelles.	ha	68-70	synuclein alpha	Homo sapiens	64-67
29936386-3	2018	A CD44 receptor targeting and endosome-pH sensitive dual functionalized hyaluronic acid-deoxycholic acid-histidine (HA-DOCA-His) micellar formulation was developed to overcome MDR, and a CD44 receptor targeting hyaluronic acid-deoxycholic acid (HA-DOCA) micelles was used as a comparison.	ha	116-118	CD44 antigen	Mus musculus	187-191
30559650-5	2018	The astroglial response was also explored by co-immunostaining for GFAP and S100b together with p-JNK and it was found to be particularly exacerbated in the MPTP+NAC+HA-1077 group.	ha	166-168	glial fibrillary acidic protein	Mus musculus	67-71
30559650-5	2018	The astroglial response was also explored by co-immunostaining for GFAP and S100b together with p-JNK and it was found to be particularly exacerbated in the MPTP+NAC+HA-1077 group.	ha	166-168	S100 protein, beta polypeptide, neural	Mus musculus	76-81
30559650-5	2018	The astroglial response was also explored by co-immunostaining for GFAP and S100b together with p-JNK and it was found to be particularly exacerbated in the MPTP+NAC+HA-1077 group.	ha	166-168	mitogen-activated protein kinase 8	Mus musculus	98-101
30203959-11	2018	The conformational stability analyses and more than 94% esterase activity of released bovine serum albumin (BSA) from (CS/HA) microcapsules conformed that the structural integrity and bioactivity were well preserved during the encapsulation and release process.	ha	122-124	albumin	Homo sapiens	93-106
28993291-3	2018	We conducted an analysis of 28 crystal structures of the serine-threonine kinase, p21-activated kinase 4 (PAK4), including three newly determined structures in complex with staurosporine, FRAX486, and fasudil (HA-1077).	ha	210-212	p21 (RAC1) activated kinase 4	Homo sapiens	82-104