PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33053533-11	2020	Newly diagnosed diabetic patients with hypertension combined with PA has a higher hypertension compared with the patients without PA.In newly diagnosed diabetic patients with hypertension, PAC may be related to insulin resistance.	pac	189-192	insulin	Homo sapiens	211-218
33227294-10	2021	CHAT rs1258267 showed marginal association with PAC in dominant model.	pac	48-51	choline O-acetyltransferase	Homo sapiens	0-4
33344896-2	2020	Here, we investigate how electron paramagnetic resonance (EPR) spectroscopy of spin-labeled fatty acid (FA) molecules binding to human serum albumin (HSA) in human serum is a suitable method for the identification of patients with PAC through detection of PAC-induced changes of FA binding to albumin.	pac	231-234	albumin	Homo sapiens	135-148
33344896-2	2020	Here, we investigate how electron paramagnetic resonance (EPR) spectroscopy of spin-labeled fatty acid (FA) molecules binding to human serum albumin (HSA) in human serum is a suitable method for the identification of patients with PAC through detection of PAC-induced changes of FA binding to albumin.	pac	256-259	albumin	Homo sapiens	135-148
32117763-7	2020	We found that compared to the controls, PAC treatment suppressed cell proliferation and promoted apoptosis in MGC-803 and SGC-7901 cells, and the Notch/PTEN/AKT axis was involved in the activating PAC-induced apoptosis.	pac	197-200	phosphatase and tensin homolog	Homo sapiens	152-156
32375110-9	2020	Overall, this study could offer guidance for water treatment plants with respect to the selection of PAC to solve the odor problems caused by various compounds (e.g., DMDS or 2-MIB), and the modification of PAC, aiming at more efficient odor removal.	pac	101-104	MIB E3 ubiquitin protein ligase 1	Homo sapiens	177-180
31811895-5	2020	P-selectin expression was significantly increased after the application of PAC.	pac	75-78	selectin P	Homo sapiens	0-10
32117763-7	2020	We found that compared to the controls, PAC treatment suppressed cell proliferation and promoted apoptosis in MGC-803 and SGC-7901 cells, and the Notch/PTEN/AKT axis was involved in the activating PAC-induced apoptosis.	pac	197-200	AKT serine/threonine kinase 1	Homo sapiens	157-160
32117763-8	2020	PAC treatment led to decreased levels of Notch (NTM), NICD, pPTEN, and pAKT compared to controls.	pac	0-3	neurotrimin	Homo sapiens	48-51
32117763-11	2020	This work reveals that PAC induces the apoptosis by suppressing activation of Notch receptor proteolytic cleavage and subsequently blocking the PTEN/AKT signaling axis in gastric cancer cells.	pac	23-26	phosphatase and tensin homolog	Homo sapiens	144-148
32117763-11	2020	This work reveals that PAC induces the apoptosis by suppressing activation of Notch receptor proteolytic cleavage and subsequently blocking the PTEN/AKT signaling axis in gastric cancer cells.	pac	23-26	AKT serine/threonine kinase 1	Homo sapiens	149-152
31521128-11	2019	CONCLUSIONS: CD8+ TIL and CD68+ TAM statuses were identified as independent prognostic factors that may be integrated into the current TNM staging system to refine risk stratification and to better predict the survival benefit from PAC in patients with GC.	pac	232-235	CD8a molecule	Homo sapiens	13-16
31878336-9	2019	We conclude that the PS2 mutation is sufficient to impair SO PAC and accelerate network dysfunctions in amyloid-accumulating mice.	pac	61-64	presenilin 2	Mus musculus	21-24
31205201-7	2019	CONCLUSION: Our results revealed that higher PAC values are strongly associated with some metabolic variables, as triglycerides, UAE, cIMT, worse ABI and major prevalence of carotid plaques that, together with elevated blood pressure values, are strictly correlated with higher risk of atherosclerosis and cardiovascular complications.	pac	45-48	CIMT	Homo sapiens	134-138
29594833-6	2019	The immunohistochemical staining pattern was consistent with PAC, as the tumor cells showed diffuse positivity for cytokeratin, vimentin and S-100, and focal positivity for bcl-2, alpha-SMA and EMA.	pac	61-64	vimentin	Homo sapiens	128-136
30753889-14	2019	We provide multiple lines of evidence that PAC in the human STN reflects the locking of spiking activity to network beta oscillations and that this coupling progressively increases with the duration of beta-bursts.	pac	43-46	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	60-63
29908843-14	2018	In conclusion, miR-210 modulates PAC functions and improves their therapeutic potential in limb ischemia.	pac	33-36	microRNA 210	Mus musculus	15-22
30583158-8	2019	When exposed to PAC concentrations ranging from 0.09 to 8.9 mug/L, the frogs displayed no observable malformations, but expressed significant increases of cyp1a mRNA levels (2- to 25-fold; indicating a suitable biomarker of exposure); however, when concentrations were of 46.6 mug/L or higher, both malformed frog phenotype and induction of cyp1a mRNA level (>250-fold) were measured (indicating a suitable biomarker of response).	pac	16-19	cytochrome P450 family 27 subfamily B member 1	Xenopus tropicalis	155-160
30583158-8	2019	When exposed to PAC concentrations ranging from 0.09 to 8.9 mug/L, the frogs displayed no observable malformations, but expressed significant increases of cyp1a mRNA levels (2- to 25-fold; indicating a suitable biomarker of exposure); however, when concentrations were of 46.6 mug/L or higher, both malformed frog phenotype and induction of cyp1a mRNA level (>250-fold) were measured (indicating a suitable biomarker of response).	pac	16-19	cytochrome P450 family 27 subfamily B member 1	Xenopus tropicalis	341-346
30583158-10	2019	In sum, cyp1a mRNA level is a highly sensitive endpoint to measure subtle molecular changes induced by PAC exposure in the frog embryos and larvae, and data suggest that PAC concentration higher than 46 mug/L would be toxic to the developing S. tropicalis.	pac	103-106	cytochrome P450 family 27 subfamily B member 1	Xenopus tropicalis	8-13
30072757-6	2018	However, PAC following NR2A-preferring antagonism was distinct from all other conditions.	pac	9-12	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	23-27
29789689-10	2018	PTH was positively associated with PAC (r = 0.119, p < 0.05) and ARR (r = 0.136, p < 0.05).	pac	35-38	parathyroid hormone	Homo sapiens	0-3
27199259-12	2016	Treatment with PAC suppressed intratumoral production of the Treg -attractant CCL22 and Treg /MDSC-attractant, CXCL12, while increasing the production of the CTL attractant, CXCL10.	pac	15-18	C-C motif chemokine ligand 22	Homo sapiens	78-83
29486299-10	2018	Strong PAC in CA3 occurred between the phase of slow-wave oscillations (<1 Hz) and the amplitude of faster rhythms (50-180 Hz), with the strongest bouts of high-frequency activity occurring preferentially on the ascending phase of the slow wave.	pac	7-10	carbonic anhydrase 3	Rattus norvegicus	14-17
29765539-7	2018	Sixty-six of the 76 (86%) PAC showed positive staining for CRM1, and 10 (14%) were completely negative.	pac	26-29	exportin 1	Homo sapiens	59-63
29166707-37	2017	Cy3-si435-PAC nanoparticles can be effectively uptaked by HL-1 cells and suppress NF-kappaB-p65 mRNA expression.	pac	10-13	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	82-91
29166707-37	2017	Cy3-si435-PAC nanoparticles can be effectively uptaked by HL-1 cells and suppress NF-kappaB-p65 mRNA expression.	pac	10-13	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	92-95
29163532-17	2017	IL-2 measurements in cocultures of rat peripheral blood lymphocytes with PAC indicated that PAC injection induced some T-cell hyporesponsiveness that was not enhanced in the cohorts additionally receiving MSC.	pac	73-76	interleukin 2	Rattus norvegicus	0-4
29163532-17	2017	IL-2 measurements in cocultures of rat peripheral blood lymphocytes with PAC indicated that PAC injection induced some T-cell hyporesponsiveness that was not enhanced in the cohorts additionally receiving MSC.	pac	92-95	interleukin 2	Rattus norvegicus	0-4
29965254-4	2017	When the dosage of PAC was 20 mg L-1 and the adsorption time ranged from 10 to 30 min, the removal rates of 3.30 mg L-1 dissolved organic carbon were 20.7%-31.9% for intracellular organic matter (IOM) and 12.6%-19.0% for extracellular organic matter (EOM).	pac	19-22	immunoglobulin kappa variable 1-16	Homo sapiens	33-36
29965254-4	2017	When the dosage of PAC was 20 mg L-1 and the adsorption time ranged from 10 to 30 min, the removal rates of 3.30 mg L-1 dissolved organic carbon were 20.7%-31.9% for intracellular organic matter (IOM) and 12.6%-19.0% for extracellular organic matter (EOM).	pac	19-22	immunoglobulin kappa variable 1-16	Homo sapiens	116-119
28668625-3	2017	PAC-coated SS significantly increased the covalent attachment of apoA-I, compared to SS alone.	pac	0-3	apolipoprotein A-I	Mus musculus	65-71
27539822-8	2017	For MCHM concentrations ranging from 2 to 5mgL-1 in the treatment plant, PAC concentrations of 0.1-1.4mgL-1 would be required to lower both MCHM isomers to the CDC screening level.	pac	73-76	LLGL scribble cell polarity complex component 1	Homo sapiens	102-107
27199259-12	2016	Treatment with PAC suppressed intratumoral production of the Treg -attractant CCL22 and Treg /MDSC-attractant, CXCL12, while increasing the production of the CTL attractant, CXCL10.	pac	15-18	C-X-C motif chemokine ligand 12	Homo sapiens	111-117
27199259-12	2016	Treatment with PAC suppressed intratumoral production of the Treg -attractant CCL22 and Treg /MDSC-attractant, CXCL12, while increasing the production of the CTL attractant, CXCL10.	pac	15-18	C-X-C motif chemokine ligand 10	Homo sapiens	174-180
24053644-8	2014	Additionally, angiogenic capacity of PAC Nrf2(-/-) in in vivo Matrigel assay and PAC mobilization in response to hind limb ischemia of Nrf2(-/-) mice were impaired.	pac	37-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	41-45
27186686-1	2016	The addition of powdered activated carbon (PAC) is an effective measure to cope with seasonal taste and odor (T&O) problems caused by 2-methylisoborneol (2-MIB) and trans-1, 10-dimethyl-trans-9-decalol (geosmin) in drinking water.	pac	43-46	MIB E3 ubiquitin protein ligase 1	Homo sapiens	160-163
27399788-1	2016	This study assessed the issue of membrane fouling in a Hybrid Membrane Process (HMP) due to the export of powdered activated carbon (PAC) fines from a pretreatment contactor.	pac	133-136	inner membrane mitochondrial protein	Homo sapiens	80-83
30035925-11	2016	Adding PAC(180 mesh) at a dosage of 15 mg L-1 into source water with the concentration of styrene was 0.02 mg L-1, which is the limited value in sanitary standard for drinking water, the concentration could be reduced to 0.001 mg L-1 and the removal rate of styrene was as high as 95.5% .	pac	7-10	immunoglobulin kappa variable 1-16	Homo sapiens	42-45
30035925-11	2016	Adding PAC(180 mesh) at a dosage of 15 mg L-1 into source water with the concentration of styrene was 0.02 mg L-1, which is the limited value in sanitary standard for drinking water, the concentration could be reduced to 0.001 mg L-1 and the removal rate of styrene was as high as 95.5% .	pac	7-10	immunoglobulin kappa variable 1-16	Homo sapiens	110-113
30035925-11	2016	Adding PAC(180 mesh) at a dosage of 15 mg L-1 into source water with the concentration of styrene was 0.02 mg L-1, which is the limited value in sanitary standard for drinking water, the concentration could be reduced to 0.001 mg L-1 and the removal rate of styrene was as high as 95.5% .	pac	7-10	immunoglobulin kappa variable 1-16	Homo sapiens	110-113
27246611-10	2016	CONCLUSION: SNPs of ERCC2/XPD and ERCC5/XPG may independently and jointly predict survival of ESCC patients treated with PAC in this study population.	pac	121-124	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	20-25
27246611-10	2016	CONCLUSION: SNPs of ERCC2/XPD and ERCC5/XPG may independently and jointly predict survival of ESCC patients treated with PAC in this study population.	pac	121-124	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	26-29
27246611-10	2016	CONCLUSION: SNPs of ERCC2/XPD and ERCC5/XPG may independently and jointly predict survival of ESCC patients treated with PAC in this study population.	pac	121-124	ERCC excision repair 5, endonuclease	Homo sapiens	34-39
27246611-10	2016	CONCLUSION: SNPs of ERCC2/XPD and ERCC5/XPG may independently and jointly predict survival of ESCC patients treated with PAC in this study population.	pac	121-124	ERCC excision repair 5, endonuclease	Homo sapiens	40-43
26633299-6	2015	Similarly, chronic exposure of cultured human PAC to nicotine (0.5 muM, 48 h) significantly inhibited thiamin uptake, which was also associated with a decrease in expression of THTR-1 and THTR-2 proteins and mRNAs.	pac	46-49	solute carrier family 19 member 2	Homo sapiens	177-183
26633299-6	2015	Similarly, chronic exposure of cultured human PAC to nicotine (0.5 muM, 48 h) significantly inhibited thiamin uptake, which was also associated with a decrease in expression of THTR-1 and THTR-2 proteins and mRNAs.	pac	46-49	solute carrier family 19 member 3	Homo sapiens	188-194
26210030-10	2015	Adsorption onto accumulating PAC in the top layer of the filter bed led to improved OMP adsorption with increasing filter runtime.	pac	29-32	olfactory marker protein	Homo sapiens	84-87
26359025-14	2015	The basal PAC level and its response to upright posture are differently associated with ACTH level in Cushing"s syndrome.	pac	10-13	proopiomelanocortin	Homo sapiens	88-92
25214397-3	2014	First we established that biotin uptake by PAC is Na(+) dependent and carrier mediated and involves sodium-dependent multivitamin transporter (SMVT).	pac	43-46	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	Mus musculus	100-141
25214397-3	2014	First we established that biotin uptake by PAC is Na(+) dependent and carrier mediated and involves sodium-dependent multivitamin transporter (SMVT).	pac	43-46	solute carrier family 5 (sodium-dependent vitamin transporter), member 6	Mus musculus	143-147
24607314-3	2014	OMP removal from wastewater treatment plant (WWTP) effluents as a point source is a preferred option with removal by adsorption onto powdered activated carbon (PAC) and OMP transformation to presumably harmless compounds by ozonation as the most promising techniques.	pac	160-163	olfactory marker protein	Homo sapiens	0-3
26844277-2	2015	Our goal was to compare the effectiveness of different PAC screening strategies in BRCA2 mutation carriers, from the standpoint of life expectancy.	pac	55-58	BRCA2 DNA repair associated	Homo sapiens	83-88
25777071-10	2015	PAC was independently related to incident cardiovascular mortality exclusively in patients with elevated PTH and vice versa.	pac	0-3	parathyroid hormone	Homo sapiens	105-108
25332235-5	2015	Using the PAC-based approach, we inhibited the proteasome to "trap" ubiquitylated substrates on the SCF(FBXW11) E3 complex.	pac	10-13	KIT ligand	Homo sapiens	100-103
25332235-5	2015	Using the PAC-based approach, we inhibited the proteasome to "trap" ubiquitylated substrates on the SCF(FBXW11) E3 complex.	pac	10-13	F-box and WD repeat domain containing 11	Homo sapiens	104-110
24525018-7	2014	Chronic alcohol exposure of PAC also led to a significant reduction in the expression of the SP1 transcription factor, which upon correction (via expression) led to the prevention of alcohol inhibitory effects on not only the activity of SLC19A2 and SLC19A3 promoters but also on the expression of THTR-1 and -2 mRNA and thiamin uptake.	pac	28-31	solute carrier family 19 (thiamine transporter), member 2	Mus musculus	238-245
24525018-7	2014	Chronic alcohol exposure of PAC also led to a significant reduction in the expression of the SP1 transcription factor, which upon correction (via expression) led to the prevention of alcohol inhibitory effects on not only the activity of SLC19A2 and SLC19A3 promoters but also on the expression of THTR-1 and -2 mRNA and thiamin uptake.	pac	28-31	solute carrier family 19, member 3	Mus musculus	250-257
24525018-7	2014	Chronic alcohol exposure of PAC also led to a significant reduction in the expression of the SP1 transcription factor, which upon correction (via expression) led to the prevention of alcohol inhibitory effects on not only the activity of SLC19A2 and SLC19A3 promoters but also on the expression of THTR-1 and -2 mRNA and thiamin uptake.	pac	28-31	solute carrier family 19 (thiamine transporter), member 2	Mus musculus	298-311
24525018-8	2014	These results demonstrate that the inhibitory effect of chronic alcohol exposure on physiological/molecular parameters of thiamin uptake by PAC is mediated via specific cis-regulatory elements in SLC19A2 and SLC19A3 minimal promoters.	pac	140-143	solute carrier family 19 (thiamine transporter), member 2	Mus musculus	196-203
23378726-8	2013	RESULTS: Among the five SNPs tested, only MFRP rs3814762 and HSP70 rs1043618 showed a nominal association with PAC.	pac	111-114	membrane frizzled-related protein	Homo sapiens	42-46
24525018-8	2014	These results demonstrate that the inhibitory effect of chronic alcohol exposure on physiological/molecular parameters of thiamin uptake by PAC is mediated via specific cis-regulatory elements in SLC19A2 and SLC19A3 minimal promoters.	pac	140-143	solute carrier family 19, member 3	Mus musculus	208-215
24041966-7	2013	Moreover, PAC were highly resistant to complement-mediated lysis and primarily responded to human complement by releasing IL-6 and IL-8.	pac	10-13	interleukin 6	Homo sapiens	122-126
24041966-7	2013	Moreover, PAC were highly resistant to complement-mediated lysis and primarily responded to human complement by releasing IL-6 and IL-8.	pac	10-13	C-X-C motif chemokine ligand 8	Homo sapiens	131-135
24447746-10	2014	CONCLUSIONS: This study revealed that appropriate PAC use effectively decreases in-hospital mortality in AHFS patients, particularly those with lower SBP or receiving inotropic therapy, suggesting that real-world PAC use could improve AHFS management.	pac	50-53	selenium binding protein 1	Homo sapiens	150-153
24447746-10	2014	CONCLUSIONS: This study revealed that appropriate PAC use effectively decreases in-hospital mortality in AHFS patients, particularly those with lower SBP or receiving inotropic therapy, suggesting that real-world PAC use could improve AHFS management.	pac	213-216	selenium binding protein 1	Homo sapiens	150-153
23378726-8	2013	RESULTS: Among the five SNPs tested, only MFRP rs3814762 and HSP70 rs1043618 showed a nominal association with PAC.	pac	111-114	heat shock protein family A (Hsp70) member 4	Homo sapiens	61-66
19936334-11	2009	Levels of PSA were significantly higher in patients with PAC and bone metastases compared with those with no bone metastases (P<0.001).	pac	57-60	kallikrein related peptidase 3	Homo sapiens	10-13
23306264-4	2013	Comparison with previous work using powdered activated carbon (PAC) revealed that for organic removal above 60% the use of GAC media incurs a significantly lower carbon usage rate than PAC.	pac	63-66	glutaminase	Homo sapiens	123-126
22524681-4	2012	The obtained results also suggest that the PAC model of acetone is likely to be fully miscible with other water models, at least with SPC and TIP4P, as well.	pac	43-46	proline rich protein gene cluster	Homo sapiens	134-137
19901341-4	2009	Our results indicate that PAC sites function as Dot6/Tod6-dependent repressor elements in vivo.	pac	26-29	Dot6p	Saccharomyces cerevisiae S288C	48-52
19901341-4	2009	Our results indicate that PAC sites function as Dot6/Tod6-dependent repressor elements in vivo.	pac	26-29	Tod6p	Saccharomyces cerevisiae S288C	53-57
23238349-2	2012	Experimental evidence suggests that liver metastasis of PAC is mediated by CXCL12/CXCR4 signaling and can be inhibited by CXCR4 antagonist.	pac	56-59	C-X-C motif chemokine ligand 12	Homo sapiens	75-81
23238349-2	2012	Experimental evidence suggests that liver metastasis of PAC is mediated by CXCL12/CXCR4 signaling and can be inhibited by CXCR4 antagonist.	pac	56-59	C-X-C motif chemokine receptor 4	Homo sapiens	82-87
23238349-2	2012	Experimental evidence suggests that liver metastasis of PAC is mediated by CXCL12/CXCR4 signaling and can be inhibited by CXCR4 antagonist.	pac	56-59	C-X-C motif chemokine receptor 4	Homo sapiens	122-127
17941686-6	2007	PAC was evaluated by the Ferric Reducing Ability of Plasma assay (FRAP), and the Oxygen Radical Absorbance Capacity assay using fluorescein (ORAC-FL).	pac	0-3	mechanistic target of rapamycin kinase	Homo sapiens	25-64
17941686-6	2007	PAC was evaluated by the Ferric Reducing Ability of Plasma assay (FRAP), and the Oxygen Radical Absorbance Capacity assay using fluorescein (ORAC-FL).	pac	0-3	mechanistic target of rapamycin kinase	Homo sapiens	66-70
12628781-4	2003	The effectiveness of PAC in the selective adsorption of ADN from aqueous solutions of ADN (ADN-F) and ADN in presence of sulfate (SO(4)(2-)) and nitrate (NO(3)(-)) ions (ADN-PS) was examined and compared using batch and column methods.	pac	21-24	complement factor D	Homo sapiens	91-96
16361055-0	2006	Determination of the optimum conditions in the removal of Bomaplex Red CR-L dye from the textile wastewater using O3, H2O2, HCO3- and PAC.	pac	134-137	interleukin 31 receptor A	Homo sapiens	71-75
9740621-9	1998	Therefore, hypertension and myocardial fibrosis induced by NO blockade may be due in part to an elevation of PAC caused by increased AT1-R in the adrenal gland.	pac	109-112	angiotensin II receptor, type 1a	Rattus norvegicus	133-138
10685608-2	2000	There was an increase in thiobarbituric acid-reactive-substances (TBARS) (60%) and in protein-associated carbonyls (PAC) (20%) in the myelin from aTf injected rats in comparison to myelin from controls, indicating a higher susceptibility to peroxidation.	pac	116-119	glial cell derived neurotrophic factor	Rattus norvegicus	146-149
8171214-5	1994	The enzyme system responsible for PAC activation is the mixed-function oxidase system and, in particular, cytochrome P-450.	pac	34-37	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	106-122
8868295-6	1996	injection of NPY (3 nmol/kg) raised plasma ALDO concentration (PAC), but not that of B (PBC); this effect of NPY was blocked by the simultaneous injection of PYX-2 (300 nmol/kg).	pac	63-66	neuropeptide Y	Rattus norvegicus	13-16
8868295-8	1996	infusion with NPY (3 nmol/kg/h for 7 days) increased PAC (but not PBC) and induced a marked hypertrophy of the zona glomerulosa (ZG) and its parenchymal cells; dispersed ZG cells obtained from NPY-infused rats displayed a significantly enhanced basal and maximally agonist-stimulated ALDO production.	pac	53-56	neuropeptide Y	Rattus norvegicus	14-17
8141353-6	1994	Iso and PAC increased MVO2 nearly equally, to approximately twice control, but produced directionally opposite changes in PCr/ATP: a significant decrease with PAC (control 1.52 +/- 0.06, PAC 1.35 +/- 0.06, means +/- SE) but a significant increase with Iso (to 1.72 +/- 0.07).	pac	8-11	ADCYAP receptor type I	Sus scrofa	187-192
8141353-6	1994	Iso and PAC increased MVO2 nearly equally, to approximately twice control, but produced directionally opposite changes in PCr/ATP: a significant decrease with PAC (control 1.52 +/- 0.06, PAC 1.35 +/- 0.06, means +/- SE) but a significant increase with Iso (to 1.72 +/- 0.07).	pac	159-162	ADCYAP receptor type I	Sus scrofa	187-192
8582487-10	1995	The increase of PAC in response to 2-hour ambulation or AII infusion was inhibited by Nif, but no inhibition of aldosterone response to ACTH was observed (Study 2).	pac	16-19	angiotensinogen	Homo sapiens	56-59
8344211-7	1993	TGF alpha-induced PAc and PAm activities were observed by 6 and 15 h of incubation, respectively, and increased rapidly between 15-21 h. LH (100 ng/ml) attenuated TGF alpha-induced PA activity by 15 h in cultures of granulosa cells from F1 and F3, but not F5-6, follicles.	pac	18-21	transforming growth factor alpha	Homo sapiens	0-9
8344211-7	1993	TGF alpha-induced PAc and PAm activities were observed by 6 and 15 h of incubation, respectively, and increased rapidly between 15-21 h. LH (100 ng/ml) attenuated TGF alpha-induced PA activity by 15 h in cultures of granulosa cells from F1 and F3, but not F5-6, follicles.	pac	18-21	transforming growth factor alpha	Homo sapiens	163-172
8344211-9	1993	TGF beta (2-100 ng/ml) stimulated PAc activity in a dose-dependent manner only in cultures of granulosa cells from F5-6 follicles and significantly enhanced TGF alpha-induced PAc and PAm activities in cell cultures from F3 and F5-6, but not F1, follicles.	pac	34-37	transforming growth factor beta 1	Homo sapiens	0-8
8344211-9	1993	TGF beta (2-100 ng/ml) stimulated PAc activity in a dose-dependent manner only in cultures of granulosa cells from F5-6 follicles and significantly enhanced TGF alpha-induced PAc and PAm activities in cell cultures from F3 and F5-6, but not F1, follicles.	pac	34-37	DLEC1 cilia and flagella associated protein	Homo sapiens	115-119
8344211-9	1993	TGF beta (2-100 ng/ml) stimulated PAc activity in a dose-dependent manner only in cultures of granulosa cells from F5-6 follicles and significantly enhanced TGF alpha-induced PAc and PAm activities in cell cultures from F3 and F5-6, but not F1, follicles.	pac	175-178	transforming growth factor beta 1	Homo sapiens	0-8
8344211-9	1993	TGF beta (2-100 ng/ml) stimulated PAc activity in a dose-dependent manner only in cultures of granulosa cells from F5-6 follicles and significantly enhanced TGF alpha-induced PAc and PAm activities in cell cultures from F3 and F5-6, but not F1, follicles.	pac	175-178	transforming growth factor alpha	Homo sapiens	157-166
34388137-3	2021	The goal of our study was the characterization of beta6-integrin (ITGB6) as a novel serum tumor marker for refined diagnosis and prognosis of PAC.	pac	142-145	integrin subunit beta 6	Homo sapiens	66-71
8507897-5	1993	In BFA-treated PAC, beta-COP was concentrated in large (0.5-1.0 micron) aggregates closely associated with remnant Golgi membranes.	pac	15-18	COPI coat complex subunit beta 2	Homo sapiens	20-28
8507897-7	1993	In ATP-depleted PAC, beta-COP was not detected on Golgi membranes but was concentrated in similar large aggregates found on the cis side of the Golgi stacks.	pac	16-19	COPI coat complex subunit beta 2	Homo sapiens	21-29
1333833-2	1992	In dexamethasone-treated rats, both NT and ACTH evoked a clearcut ZG-cell hypertrophy, but only NT was able to raise PAC.	pac	117-120	neurotensin	Rattus norvegicus	96-98
1407418-8	1992	However, also under these conditions of profound adrenal atrophy AVP was still able to notably raise PAC, while NT was ineffective.	pac	101-104	arginine vasopressin	Rattus norvegicus	65-68
1843269-8	1991	These findings suggest that hANP suppresses PAC regardless of electrocyte imbalances and/or volume change induced by kidney dysfunction and that the kidney may be important in degrading hANP.	pac	44-47	natriuretic peptide A	Homo sapiens	28-32
34388137-10	2021	Given the limited specificity and sensitivity of currently used carbohydrate antigen 19-9-based assays, ITGB6 may have the potential to improve the diagnostic accuracy for PAC.	pac	172-175	integrin subunit beta 6	Homo sapiens	104-109
34035168-5	2021	We found that prespacers are bound by both Cas1 (presumably, as part of the Cas1-Cas2 integrase) and Cas3, implying direct physical association of the interference and adaptation machineries as part of PAC.	pac	202-205	BCAR1 scaffold protein, Cas family member	Homo sapiens	43-47
34035168-5	2021	We found that prespacers are bound by both Cas1 (presumably, as part of the Cas1-Cas2 integrase) and Cas3, implying direct physical association of the interference and adaptation machineries as part of PAC.	pac	202-205	embryonal Fyn-associated substrate	Homo sapiens	101-105
34609407-11	2021	Our results sustain the role of HOXB13 and TFF3 in the stratification of PAC.	pac	73-76	homeobox B13	Homo sapiens	32-38
34124069-4	2021	Because Tyrosine-protein phosphatase non-receptor type 9 (PTPN9) is reported to be a negative regulator of stem cell differentiation and angiogenesis signaling, we investigated its effect on PAC activity in the context of OIR.	pac	191-194	protein tyrosine phosphatase, non-receptor type 9	Rattus norvegicus	8-56
34609407-11	2021	Our results sustain the role of HOXB13 and TFF3 in the stratification of PAC.	pac	73-76	trefoil factor 3	Homo sapiens	43-47
6092533-1	1984	The binding of Fe(III)-polyaminocarboxylate (pac) complexes to mitochondrial ferricytochrome c and ferrocytochrome c has been studied by NMR and four binding sites on cytochrome c have been defined.	pac	45-48	cytochrome c, somatic	Homo sapiens	82-94
35557476-7	2022	Since additional immunohistochemistry revealed that tumor cells were diffusely positive for both NKX3.1 and PSMA, the cytological diagnosis was suspected metastatic PAC.	pac	165-168	folate hydrolase 1	Homo sapiens	108-112
3569605-14	1987	administration of OT (0.1 approximately 0.2 IU/min) suppressed angiotensin II-induced increase of PAC and elevation of blood pressure in both EH and NT.	pac	98-101	angiotensinogen	Homo sapiens	63-77
35344825-2	2022	MATERIALS AND METHODS: MEDLINE, EMBASE, Cochrane library and Web of Science were systematically screened to identify most relevant studies on patients with CS comparing PAC use to non-use during hospital stay.	pac	169-172	citrate synthase	Homo sapiens	156-158
35344825-9	2022	CONCLUSIONS: PAC was associated with lower incidence of short-term mortality in CS pooling adjusted observational studies.	pac	13-16	citrate synthase	Homo sapiens	80-82
35507302-10	2022	In addition, the use of S100, MSA, p40, and c-Kit provide additional layers of information helpful to differentiate PAC from adenoid cystic carcinoma, one of challenging differential diagnoses.	pac	116-119	tumor protein p63	Homo sapiens	35-38
35507302-10	2022	In addition, the use of S100, MSA, p40, and c-Kit provide additional layers of information helpful to differentiate PAC from adenoid cystic carcinoma, one of challenging differential diagnoses.	pac	116-119	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	44-49
35612936-4	2022	Four single-center before-and-after studies and one multicenter registry study have demonstrated improved outcomes in patients with CS, potentially driven by increased pulmonary artery catheter (PAC) utilization and earlier (and more appropriate) initiation of MCS.	pac	195-198	citrate synthase	Homo sapiens	132-134
35044789-9	2022	The combined 2DG and CAR T cell therapy was successful against multiple carcinomas besides PAC, including those arising from the lung, ovary, and bladder, and with different clinically relevant CAR specificities, such as CD44v6 and CEA.	pac	91-94	nuclear receptor subfamily 1, group I, member 3	Mus musculus	21-24
7032984-3	1981	PAC increased dose-dependently upon infusion rates of angiotensin II (0.2, 0.4, 0.8, 1.0, 1.2, 2.5 and 5.0 ng/kg/min) on each occasion, but aldosterone responsiveness to infused angiotensin II (change and percentage from base line levels) was not altered by the suppression of endogenous ACTH secretion with dexamethasone with each incremental infusion of the octapeptide.	pac	0-3	angiotensinogen	Homo sapiens	54-68
6274907-7	1982	AII in the presence of vehicle increased PAC from 5.4 +/- 1.3 to 19.9 +/- 2.9 ng/100 ml; AII in the presence of dopamine increased PAC from 4.8 +/- 0.5 to 19.5 +/- 1.8 ng/100 ml (P = NS).	pac	41-44	angiotensinogen	Homo sapiens	0-3
6277835-9	1982	These results indicate that during exercise acute hypoxia changes the usual close relationship between PAC and PRA by reducing ACE activity.	pac	103-106	angiotensin I converting enzyme	Homo sapiens	127-130
12002592-7	1983	It was concluded that heart failure in the dog increases PAC, most likely because of renin-angiotensin-aldosterone-system activation, and that the increase is related directly to the clinical status of the patient.	pac	57-60	renin	Canis lupus familiaris	85-90
6757774-7	1982	The adrenal responses of PAC to angiotensin II may also be impaired.	pac	25-28	angiotensinogen	Homo sapiens	32-46
7032984-3	1981	PAC increased dose-dependently upon infusion rates of angiotensin II (0.2, 0.4, 0.8, 1.0, 1.2, 2.5 and 5.0 ng/kg/min) on each occasion, but aldosterone responsiveness to infused angiotensin II (change and percentage from base line levels) was not altered by the suppression of endogenous ACTH secretion with dexamethasone with each incremental infusion of the octapeptide.	pac	0-3	angiotensinogen	Homo sapiens	178-192
7032984-3	1981	PAC increased dose-dependently upon infusion rates of angiotensin II (0.2, 0.4, 0.8, 1.0, 1.2, 2.5 and 5.0 ng/kg/min) on each occasion, but aldosterone responsiveness to infused angiotensin II (change and percentage from base line levels) was not altered by the suppression of endogenous ACTH secretion with dexamethasone with each incremental infusion of the octapeptide.	pac	0-3	proopiomelanocortin	Homo sapiens	288-292
33713943-7	2021	On the other hand, MAGI2 was detected in 91.1% of PAC versus 17.2% of NPH.	pac	50-53	membrane associated guanylate kinase, WW and PDZ domain containing 2	Homo sapiens	19-24
33713943-12	2021	CONCLUSION: This study recommends using both ERG and MAGI2 in a cocktail for better diagnostic validity of PAC.	pac	107-110	ETS transcription factor ERG	Homo sapiens	45-48
33713943-12	2021	CONCLUSION: This study recommends using both ERG and MAGI2 in a cocktail for better diagnostic validity of PAC.	pac	107-110	membrane associated guanylate kinase, WW and PDZ domain containing 2	Homo sapiens	53-58
33925729-9	2021	Both Nec-1 and RIPK1K45A modification inhibited TLCS- and FAEE-induced PAC necrosis in vitro.	pac	71-74	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	15-20