PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2552440-4	1989	ATPase (dATPase) is specific for adenine nucleotides; ATP and dATP, but not CTP, UTP, or GTP, are hydrolyzed.	2'-deoxyadenosine triphosphate	8-12	Vacuolar H[+] ATPase 14kD subunit 1	Drosophila melanogaster	0-6
2538159-5	1989	Thymidylate kinase could utilize either ATP or dATP as an efficient phosphate donor, and showed substrate specificity for dTMP.	2'-deoxyadenosine triphosphate	47-51	deoxythymidylate kinase	Homo sapiens	0-18
2673351-7	1989	In the absence of SSB protein, the rate of joint molecule and product formation in the DNA strand exchange reaction is greater in the presence of dATP than in the presence of rATP.	2'-deoxyadenosine triphosphate	146-150	single-stranded DNA-binding protein	Escherichia coli	18-21
2673351-8	1989	The rate of product formation in the dATP-dependent reaction is also faster than the rATP-dependent reaction when SSB protein is added to the ssDNA before recA protein; the rate of rATP-dependent product formation is inhibited 10-fold under these conditions.	2'-deoxyadenosine triphosphate	37-41	single-stranded DNA-binding protein	Escherichia coli	114-117
3091344-8	1986	Currently, the authors are exploiting BuPdGTP, BuPdGDP, and similar butylanilino derivatives of dATP to probe the active site of pol alpha and to develop other N2-substituted analogues which can bind selectively to the substrate sites of other important polymerases and nucleotide binding proteins.	2'-deoxyadenosine triphosphate	96-100	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	129-138
3049549-4	1988	We found that RecA1202 and RecA1211 proteins, in contrast to RecA+, can use natural NTPs other than ATP and dATP as cofactors in the cleavage of LexA repressor.	2'-deoxyadenosine triphosphate	108-112	DNA repair system	Escherichia coli	145-149
3049549-5	1988	The effectiveness of NTPs in promoting LexA cleavage by RecA1202 and RecA1211 proteins decreased in roughly the following order: dATP greater than ATP greater than UTP greater than ATP-gamma S greater than dCTP greater than CTP greater than dGTP greater than GTP greater than TTP.	2'-deoxyadenosine triphosphate	129-133	DNA repair system	Escherichia coli	39-43
2839505-5	1988	Of the common nucleoside triphosphates, only ATP and dATP were hydrolyzed by the VETF-associated ATPase.	2'-deoxyadenosine triphosphate	53-57	dynein axonemal heavy chain 8	Homo sapiens	97-103
2839144-6	1988	The purine 5"-nucleotidase is inhibited by Pi, and is strongly stimulated by ATP, dATP and GTP, and by glycerate 2,3-bisphosphate.	2'-deoxyadenosine triphosphate	82-86	5'-nucleotidase ecto	Homo sapiens	11-26
3112523-4	1987	Abnormalities in the metabolism of the nucleotide substrates for polymerization are likely to be of major importance in mutants designated Aph-2 and Aph-3, as there were marked alterations in the dCTP and dATP pool sizes.	2'-deoxyadenosine triphosphate	205-209	alphaprotein 2	Mus musculus	139-144
3473993-2	1987	The kinase prefers phosvitin over casein (Vmax phosvitin greater than Vmax casein; apparent Km 0.5 microM phosvitin and 3.3 microM casein) and utilizes as cosubstrate ATP (apparent Km 3-4 microM), GTP (apparent Km 4-5 microM) and other purine nucleoside triphosphates, including dATP and dGTP but not pyrimidine nucleoside triphosphates.	2'-deoxyadenosine triphosphate	279-283	casein kinase 2 beta	Homo sapiens	19-28
3473993-2	1987	The kinase prefers phosvitin over casein (Vmax phosvitin greater than Vmax casein; apparent Km 0.5 microM phosvitin and 3.3 microM casein) and utilizes as cosubstrate ATP (apparent Km 3-4 microM), GTP (apparent Km 4-5 microM) and other purine nucleoside triphosphates, including dATP and dGTP but not pyrimidine nucleoside triphosphates.	2'-deoxyadenosine triphosphate	279-283	casein kinase 2 beta	Homo sapiens	47-56
3473993-2	1987	The kinase prefers phosvitin over casein (Vmax phosvitin greater than Vmax casein; apparent Km 0.5 microM phosvitin and 3.3 microM casein) and utilizes as cosubstrate ATP (apparent Km 3-4 microM), GTP (apparent Km 4-5 microM) and other purine nucleoside triphosphates, including dATP and dGTP but not pyrimidine nucleoside triphosphates.	2'-deoxyadenosine triphosphate	279-283	casein kinase 2 beta	Homo sapiens	47-56
3500370-3	1987	The dATP concentrations in HCL, BCL and TCL increased from means of 2.9, 1.8 and 3.0 to 100.3, 68.2 and 51.3 pmol/10(6) cells respectively after 2 h with 10(-5) M dCF and 10(-4)M deoxyadenosine.	2'-deoxyadenosine triphosphate	4-8	ras homolog family member J	Homo sapiens	40-43
3539181-5	1986	In addition, studies performed in the presence of single-stranded DNA demonstrated that the affinity of ATP, dATP, ATP-gamma-S, and AMP-PNP for recA protein is significantly increased.	2'-deoxyadenosine triphosphate	109-113	RAD51 recombinase	Homo sapiens	144-148
4055759-6	1985	We examined the ability of dATP/ATP to cross-link to eIF-4A and found that it cross-links less efficiently (approximately 60-fold on a molar basis) compared to the cross-linking obtained for the eIF-4A component of the cap-binding protein complex.	2'-deoxyadenosine triphosphate	27-31	eukaryotic translation initiation factor 4A1	Homo sapiens	53-59
4055759-7	1985	Irradiation of purified eIF-4A together with the cap-binding protein complex in the presence of [alpha-32P]dATP resulted in greater than additive labeling of the eIF-4A component of the cap-binding protein complex and purified eIF-4A, suggesting a synergistic interaction between purified eIF-4A, the cap-binding protein complex, and dATP/ATP.	2'-deoxyadenosine triphosphate	107-111	eukaryotic translation initiation factor 4A1	Homo sapiens	24-30
4055759-7	1985	Irradiation of purified eIF-4A together with the cap-binding protein complex in the presence of [alpha-32P]dATP resulted in greater than additive labeling of the eIF-4A component of the cap-binding protein complex and purified eIF-4A, suggesting a synergistic interaction between purified eIF-4A, the cap-binding protein complex, and dATP/ATP.	2'-deoxyadenosine triphosphate	107-111	eukaryotic translation initiation factor 4A1	Homo sapiens	162-168
4055759-7	1985	Irradiation of purified eIF-4A together with the cap-binding protein complex in the presence of [alpha-32P]dATP resulted in greater than additive labeling of the eIF-4A component of the cap-binding protein complex and purified eIF-4A, suggesting a synergistic interaction between purified eIF-4A, the cap-binding protein complex, and dATP/ATP.	2'-deoxyadenosine triphosphate	107-111	eukaryotic translation initiation factor 4A1	Homo sapiens	162-168
4055759-7	1985	Irradiation of purified eIF-4A together with the cap-binding protein complex in the presence of [alpha-32P]dATP resulted in greater than additive labeling of the eIF-4A component of the cap-binding protein complex and purified eIF-4A, suggesting a synergistic interaction between purified eIF-4A, the cap-binding protein complex, and dATP/ATP.	2'-deoxyadenosine triphosphate	107-111	eukaryotic translation initiation factor 4A1	Homo sapiens	162-168
3172342-1	1988	The transition step from the p3-dAMP initiation complex to the first elongated products, p3-(dAMP)2 and p3-(dAMP)3, requires a dATP concentration higher than that needed for the initiation reaction or for the further elongation of the p3-(dAMP)3 complex.	2'-deoxyadenosine triphosphate	127-131	exosome component 10	Homo sapiens	89-99
3172342-1	1988	The transition step from the p3-dAMP initiation complex to the first elongated products, p3-(dAMP)2 and p3-(dAMP)3, requires a dATP concentration higher than that needed for the initiation reaction or for the further elongation of the p3-(dAMP)3 complex.	2'-deoxyadenosine triphosphate	127-131	exosome component 10	Homo sapiens	104-114
3172342-1	1988	The transition step from the p3-dAMP initiation complex to the first elongated products, p3-(dAMP)2 and p3-(dAMP)3, requires a dATP concentration higher than that needed for the initiation reaction or for the further elongation of the p3-(dAMP)3 complex.	2'-deoxyadenosine triphosphate	127-131	exosome component 10	Homo sapiens	235-245
3050447-5	1988	F-dATP was able to completely substitute for dATP using DNA polymerase alpha and gamma, but not with DNA polymerase beta.	2'-deoxyadenosine triphosphate	2-6	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	56-76
3498909-1	1987	In thymocytes of C3HA mice carrying the transplantable and ortoaminoazotoluene induced hepatomas at the time of their intense growth a drastic decrease in adenosine deaminase activity set in and 3-4-fold augmentation of intracellular concentration of dATP and dGTP, potential inhibitors of ribonucleoside diphosphate reductase was observed, leading to the reduction of the DNA synthesis.	2'-deoxyadenosine triphosphate	251-255	adenosine deaminase	Mus musculus	155-174
3438251-7	1987	The Km for individual dNTP with all three species of TdT is quite similar and decreases in the order dCTP greater than dTTP greater than dATP greater than dGTP.	2'-deoxyadenosine triphosphate	137-141	DNA nucleotidylexotransferase	Bos taurus	53-56
3466358-8	1986	Transformants with FPGS activity that showed a human enzyme preference for dATP also had folate polyglutamate chain lengths characteristic of the human enzyme.	2'-deoxyadenosine triphosphate	75-79	folylpolyglutamate synthase	Homo sapiens	19-23
3539181-3	1986	Quantitative analysis of the cross-linking inhibition studies using a variety of nucleotide cofactors as competitors has shown that the binding affinity of adenine-containing nucleotides for recA protein decreases in the following order: ATP-gamma-S greater than dATP greater than ATP greater than adenylyl beta,gamma-imidodiphosphate (AMP-PNP) much greater than adenylyl beta,gamma-methylenediphosphate (AMP-PCP) approximately adenine.	2'-deoxyadenosine triphosphate	263-267	RAD51 recombinase	Homo sapiens	191-195
2943735-8	1986	Radioactive ATP and dATP can be photocross-linked to factor A by UV irradiation.	2'-deoxyadenosine triphosphate	20-24	general transcription factor 3A L homeolog	Xenopus laevis	53-61
3915049-3	1985	Although many of the kinetic properties of the enzyme remain unaltered in cells at high MPD, changes in the extent and kinetic mechanism of inhibition of CDP and ADP reductase activity by dATP, the overall negative effector of ribonucleotide reductase, were observed.	2'-deoxyadenosine triphosphate	188-192	cut like homeobox 1	Homo sapiens	154-157
3931053-4	1985	BuAdATP, like BuPdGTP, also inhibits pol alpha-catalysed reactions directed by non-complementary, thymine-deficient templates, and it does so via a mechanism subject to specific antagonism by its natural homolog, dATP.	2'-deoxyadenosine triphosphate	3-7	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	37-46
3876835-6	1985	Interestingly, both thymocytes and tonsil-derived B-lymphocytes, and a partially ADA deficient B lymphoblast line, accumulated detectable amounts of dATP even in the absence of ADA inhibition.	2'-deoxyadenosine triphosphate	149-153	adenosine deaminase	Homo sapiens	81-84
3876835-9	1985	ADA inhibited thymocytes and tonsillar B-lymphocytes accumulated very high dATP levels, which were sustained to an equal extent by both over a 60-min period; PBMs accumulated the lowest values.	2'-deoxyadenosine triphosphate	75-79	adenosine deaminase	Homo sapiens	0-3
3993904-6	1985	Epsilon dATP binds about twofold tighter than dATP to terminal transferase, but has a twofold-lower catalytic rate.	2'-deoxyadenosine triphosphate	8-12	DNA nucleotidylexotransferase	Homo sapiens	54-74
3838797-2	1985	Severe genetic deficiency of ADA leads to an immunological deficiency state in which T-lymphoid cells are selectively destroyed by the accumulation of toxic levels of deoxyadenosine and deoxy-ATP.	2'-deoxyadenosine triphosphate	186-195	adenosine deaminase	Homo sapiens	29-32
3993904-6	1985	Epsilon dATP binds about twofold tighter than dATP to terminal transferase, but has a twofold-lower catalytic rate.	2'-deoxyadenosine triphosphate	46-50	DNA nucleotidylexotransferase	Homo sapiens	54-74
3856251-2	1985	cDNAs corresponding to murine IFN-alpha and murine IFN-beta labeled by nick-translation to high specific activity (2-4 X 10(8) dpm/micrograms) with alpha-35S-labeled dATP were used as probes for hybridization with IFN mRNA in mouse C-243 cells induced with Newcastle disease virus.	2'-deoxyadenosine triphosphate	166-170	interferon beta 1, fibroblast	Mus musculus	51-59
6387175-11	1984	Hydroxyurea, EDTA, dATP, and dTTP inhibited CDP reduction, setting this reductase apart from T4 reductase, which is not inhibited by dATP, and from herpesvirus reductase, which requires no activation and is insensitive to deoxyribonucleoside triphosphate inhibition.	2'-deoxyadenosine triphosphate	133-137	ttp	Drosophila melanogaster	29-33
6334686-2	1984	It was found that in the presence of deoxycoformycin, an inhibitor of adenosine deaminase, deoxyadenosine was the only product of deoxy-ATP catabolism.	2'-deoxyadenosine triphosphate	130-139	adenosine deaminase	Homo sapiens	70-89
6208191-4	1984	The ATPase hydrolyzed the gamma phosphate from only ATP or dATP.	2'-deoxyadenosine triphosphate	59-63	dynein axonemal heavy chain 8	Homo sapiens	4-10
6147383-2	1984	Low activities of the ectoenzymes ecto-5"-nucleotidase and ecto-ATPase have each been associated with deoxyadenosine sensitivity and dATP accumulation in human T-lymphoblasts.	2'-deoxyadenosine triphosphate	133-137	5'-nucleotidase ecto	Homo sapiens	34-54
6424986-4	1984	Detailed metabolic experiments comparing viability and deoxynucleotide accumulation showed that B cell lines of malignant origin also accumulated high levels of dATP from 2"-deoxyadenosine (dAR), and dGTP from 2"-deoxyguanosine (dGR) as effectively as T cells--even without inhibitors, however, dAR reduced cell viability only when ADA was inhibited by dCF, whilst dGR was equally toxic with or without inhibitor, even to a line which accumulated no dGTP.	2'-deoxyadenosine triphosphate	161-165	Allatostatin A receptor 2	Drosophila melanogaster	190-193
6332978-5	1984	dAdo caused elevation of the dATP pool to a similar extent in G1, S, and G2 - M-enriched cell fractions, but did not cause a fall in the dCTP pool.	2'-deoxyadenosine triphosphate	29-33	ado	Drosophila melanogaster	0-4
6332978-6	1984	These findings indicate that dAdo induces a G1 block via elevation of dATP pools, apparently independently of inhibition of ribonucleotide reductase.	2'-deoxyadenosine triphosphate	70-74	ado	Drosophila melanogaster	29-33
6610485-2	1984	The addition of deoxyadenosine to ADA-inhibited (but not to uninhibited) cells generated increased dATP pools (up to 50-fold greater than controls) and depressed the mitogen response.	2'-deoxyadenosine triphosphate	99-103	adenosine deaminase	Homo sapiens	34-37
6424679-11	1984	A partially HGPRT deficient line formed extremely high dATP levels, well in excess of those formed by the T-cell line CEM.	2'-deoxyadenosine triphosphate	55-59	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	12-17
6362851-2	1984	In the presence of dipyridamole and 2"-deoxyadenosine and when adenosine deaminase was inhibited with deoxycoformycin, the L1210 leukemia cell which is a non-T-, non-B-cell type accumulated dATP like a T-cell type.	2'-deoxyadenosine triphosphate	190-194	adenosine deaminase	Mus musculus	63-82
6142725-5	1984	ATPases B, C2, and C3 hydrolyze dATP as efficiently as ATP, whereas C1 does not.	2'-deoxyadenosine triphosphate	32-36	complement component 3	Mus musculus	11-21
6698284-7	1984	Human GMP synthetase is inhibited by ATP, dATP, azaserine, and hydroxylamine.	2'-deoxyadenosine triphosphate	42-46	guanine monophosphate synthase	Homo sapiens	6-20
6098441-5	1984	The apparent Km of the enzyme for dUTP and dTTP was approximately 20 mumol/l while the apparent Km for dATP, ATP, dCTP, CTP and UTP was in the range of 65-80 mumol/l.	2'-deoxyadenosine triphosphate	103-107	ttp	Drosophila melanogaster	43-47
6187447-1	1983	In the presence of the adenosine deaminase inhibitor erythro-9-[3(2-hydroxynonyl)]adenine microM concentrations of 2"-deoxyadenosine (dAdo) are toxic to nondividing human lymphoid cells and induce G1-phase arrest in T-leukemic lymphoblasts, effects which appear to be independent of ribonucleotide reductase inhibition by accumulated 2"-deoxyadenosine 5"-triphosphate.	2'-deoxyadenosine triphosphate	334-367	adenosine deaminase	Homo sapiens	23-42
6414755-5	1983	The initial finding of detectable amounts of deoxy-ATP and deoxy-GTP in mononuclear cells from children with two distinct inherited immunodeficiency disorders [adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) deficiency respectively] many have been due to contamination by nucleated erythrocytes as well as platelets in non-defibrinated preparations.	2'-deoxyadenosine triphosphate	45-54	adenosine deaminase	Homo sapiens	160-179
6414755-6	1983	Defibrination before nucleotide extraction of mononuclear cells from a patient with T-cell leukaemic/lymphoma treated with the ADA inhibitor deoxycoformycin enabled the demonstration of grossly raised deoxy-ATP levels relative to deoxy-ADP levels (ratio 16.1:1), associated with severe ATP depletion.	2'-deoxyadenosine triphosphate	201-210	adenosine deaminase	Homo sapiens	127-130
6603241-3	1983	We have found that non-T, non-B acute lymphoblastic leukemia cells with low ecto-5"-nucleotidase and high adenosine deaminase activities increase their dATP pools by greater than tenfold when exposed to deoxyadenosine and an inhibitor of adenosine deaminase in culture.	2'-deoxyadenosine triphosphate	152-156	5'-nucleotidase ecto	Homo sapiens	76-96
6187447-1	1983	In the presence of the adenosine deaminase inhibitor erythro-9-[3(2-hydroxynonyl)]adenine microM concentrations of 2"-deoxyadenosine (dAdo) are toxic to nondividing human lymphoid cells and induce G1-phase arrest in T-leukemic lymphoblasts, effects which appear to be independent of ribonucleotide reductase inhibition by accumulated 2"-deoxyadenosine 5"-triphosphate.	2'-deoxyadenosine triphosphate	334-367	ado	Drosophila melanogaster	134-138
6958362-5	1982	On the other hand, potentiation of MTX toxicity by purines was associated with substantial increases in deoxyadenosine 5"-triphosphate levels in conjunction with low deoxythymidine 5"-triphosphate levels.	2'-deoxyadenosine triphosphate	104-134	metaxin 1	Homo sapiens	35-38
6290030-5	1982	Increasing concentrations of adenosine 5"-triphosphate and deoxyadenosine 5"-triphosphate from 0 to 3 mM enhanced 5"-nucleotidase activity up to 7-fold.	2'-deoxyadenosine triphosphate	59-89	5'-nucleotidase ecto	Homo sapiens	114-129
6752137-7	1982	Natural feedback inhibitors dATP or dTTP inhibited incorporation of labeled ribo-CDP into deoxyribonucleotides and into DNA to the same extent.	2'-deoxyadenosine triphosphate	28-32	cut like homeobox 1	Homo sapiens	81-84
6290030-8	1982	The activation of this 5"-nucleotidase by deoxyadenosine 5"-triphosphate, combined with the relative inability of the enzyme to dephosphorylate deoxyadenosine 5"-monophosphate, conceivably may contribute to the adenine nucleotide degradation induced by deoxyadenosine in normal and malignant lymphocytes.	2'-deoxyadenosine triphosphate	42-72	5'-nucleotidase ecto	Homo sapiens	23-38
6980665-2	1982	Incubation with dCF and AdR resulted in a significant rise of dATP concentrations in all groups (the highest rises occurring in the leukaemic groups particularly in AML and Thy-ALL).	2'-deoxyadenosine triphosphate	62-66	aldo-keto reductase family 1 member B	Homo sapiens	24-27
6281270-0	1982	Effects of mutational loss of adenosine kinase and deoxycytidine kinase on deoxyATP accumulation and deoxyadenosine toxicity in cultured CEM human T-lymphoblastoid cells.	2'-deoxyadenosine triphosphate	75-83	adenosine kinase	Homo sapiens	30-46
7082375-1	1982	A reciprocal relationship between erythrocyte ATP and deoxy-ATP levels has been noted in an immunodeficient child with adenosine deaminase (ADA) deficiency during therapy with red cell transfusions.	2'-deoxyadenosine triphosphate	54-63	adenosine deaminase	Homo sapiens	119-138
6980023-1	1982	dATP, dADP, and dAMP equalled or exceeded the depleted levels of ATP, ADP, and AMP in erythrocytes from two children with adenosine deaminase (ADA; EC 3.5.4.4) deficiency.	2'-deoxyadenosine triphosphate	0-4	adenosine deaminase	Homo sapiens	122-141
6980023-1	1982	dATP, dADP, and dAMP equalled or exceeded the depleted levels of ATP, ADP, and AMP in erythrocytes from two children with adenosine deaminase (ADA; EC 3.5.4.4) deficiency.	2'-deoxyadenosine triphosphate	0-4	adenosine deaminase	Homo sapiens	143-146
6978147-2	1982	In the presence of an inhibitor of adenosine deaminase, micromolar concentrations of dAdo caused elevation of deoxyadenosine-5"-triphosphate (dATP) pools and in vitro lysis of non-dividing PBL and CLL lymphocytes.	2'-deoxyadenosine triphosphate	110-140	adenosine deaminase	Homo sapiens	35-54
6978147-2	1982	In the presence of an inhibitor of adenosine deaminase, micromolar concentrations of dAdo caused elevation of deoxyadenosine-5"-triphosphate (dATP) pools and in vitro lysis of non-dividing PBL and CLL lymphocytes.	2'-deoxyadenosine triphosphate	142-146	adenosine deaminase	Homo sapiens	35-54
6980005-1	1982	The accumulation of deoxyadenosine triphosphate (dATP) in erythrocytes of mice treated with the adenosine deaminase inhibitor deoxycoformycin was studied in an attempt to establish and evaluate a model system for the study of at least some biochemical aspects of hereditary adenosine deaminase deficiency.	2'-deoxyadenosine triphosphate	20-47	adenosine deaminase	Mus musculus	96-115
6980005-1	1982	The accumulation of deoxyadenosine triphosphate (dATP) in erythrocytes of mice treated with the adenosine deaminase inhibitor deoxycoformycin was studied in an attempt to establish and evaluate a model system for the study of at least some biochemical aspects of hereditary adenosine deaminase deficiency.	2'-deoxyadenosine triphosphate	49-53	adenosine deaminase	Mus musculus	96-115
6283540-1	1982	Loss of ATP accompanying accumulation of dATP has recently been reported to occur in the erythrocytes and lymphoblasts of patients with T lymphocytic leukemia during treatment with deoxycoformycin, an inhibitor of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) that causes the accumulation of deoxyadenosine.	2'-deoxyadenosine triphosphate	41-45	adenosine deaminase	Homo sapiens	214-233
6283540-1	1982	Loss of ATP accompanying accumulation of dATP has recently been reported to occur in the erythrocytes and lymphoblasts of patients with T lymphocytic leukemia during treatment with deoxycoformycin, an inhibitor of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) that causes the accumulation of deoxyadenosine.	2'-deoxyadenosine triphosphate	41-45	adenosine deaminase	Homo sapiens	235-259
7082375-1	1982	A reciprocal relationship between erythrocyte ATP and deoxy-ATP levels has been noted in an immunodeficient child with adenosine deaminase (ADA) deficiency during therapy with red cell transfusions.	2'-deoxyadenosine triphosphate	54-63	adenosine deaminase	Homo sapiens	140-143
7024267-8	1981	The isolated mutant protein M1 from dGuo-200-1 cells has a CDP reductase activity which is stimulated by dATP, unlike the wild type enzyme which is inhibited by dATP.	2'-deoxyadenosine triphosphate	105-109	cut-like homeobox 1	Mus musculus	59-62
6244157-6	1980	It shows rigorous specificity for AMP (dAMP) was phosphate acceptor but is rather unspecific for the triphosphate donor since, UTP, CTP, ITP and GTP may substitute for ATP (dATP).	2'-deoxyadenosine triphosphate	173-177	ATPase phospholipid transporting 8A2	Homo sapiens	168-171
6261008-5	1981	This latter enzyme was similar to the herpes simplex virus-induced reductase described by others in its lack of requirement for Mg2 and its resistance to inhibition by dTTP and dATP; in addition, we found that it was inhibited by ATP, whereas the enzyme from control cells displayed an absolute requirement for the nucleotide.	2'-deoxyadenosine triphosphate	177-181	mucin 7, secreted	Homo sapiens	128-131
7000802-3	1980	ADP and CDP reductase was characterized for its response to the positive effectors, ATP and dGTP, the negative effector dATP, and the reducing agent dithiothreitol.	2'-deoxyadenosine triphosphate	120-124	WD and tetratricopeptide repeats 1	Homo sapiens	0-11
6965496-5	1980	These elevated concentrations of adenosine, deoxyadenosine, and dATP are similar to those we observed in another older adenosine deaminase-deficient patient and may explain the impaired immune function and lymphopenia seen at birth.	2'-deoxyadenosine triphosphate	64-68	adenosine deaminase	Homo sapiens	119-138
6458284-1	1981	Ecto-ATPase in rat cauda-epididymal intact spermatozoa has a high degree of substrate specificity for the hydrolysis of ATP and dATP rather than of ADP, AMP, GTP, dGTP, CTP, dCTP, TTP and UTP.	2'-deoxyadenosine triphosphate	128-132	CEA cell adhesion molecule 1	Rattus norvegicus	0-11
6166246-3	1981	Ara-ATP and ara-CTP inhibited the DNA polymerase test competitively with respect to dATP and dCTP, respectively.	2'-deoxyadenosine triphosphate	84-88	cut up	Drosophila melanogaster	16-19
6997299-8	1980	The reduced activity of ribonucleotide reductase in the simulated adenosine deaminase-deficient HeLa cells provides direct evidence for the thesis that adenosine deaminase deficiency disease is mediated through elevated levels of dATP which inhibit ribonucleotide reductase.	2'-deoxyadenosine triphosphate	230-234	adenosine deaminase	Homo sapiens	66-85
6254019-0	1980	Resistance of an adenosine kinase-deficient human lymphoblastoid cell line to effects of deoxyadenosine on growth, S-adenosylhomocysteine hydrolase inactivation, and dATP accumulation.	2'-deoxyadenosine triphosphate	166-170	adenosine kinase	Homo sapiens	17-33
6254019-1	1980	Accumulation of dATP derived from 2"-deoxyadenosine (dAdo), causing inhibition of ribonucleotide reductase and depletion of the other deoxynucleotide substrates required for DNA synthesis, has been suggested as the cause of the lymphopenia and immune defect in inheritable deficiency of adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4).	2'-deoxyadenosine triphosphate	16-20	adenosine deaminase	Homo sapiens	308-332
6244157-7	1980	ATP and MgATP (dATP was not tested) bind to the enzyme with dissociation constants of 0.122 and 0.132 mM respectively, while AMP (dAMP was not tested), UTP, CTP, ITP and GTP binding could not be detected by the dialysis equilibrium technique used.	2'-deoxyadenosine triphosphate	15-19	ATPase phospholipid transporting 8A2	Homo sapiens	0-3
313967-1	1979	The rate of DNA synthesis in cultured diploid fibroblasts, nonmalignant human cells, is decreased by 50 microM 2"-deoxyadenosine when adenosine deaminase is inhibited and 2"-deoxyadenosine is phosphorylated to dATP.	2'-deoxyadenosine triphosphate	210-214	adenosine deaminase	Homo sapiens	134-153
468845-7	1979	ATP inhibits the reaction catalyzed by terminal transferase isolated from human lymphoblasts due to mutual recognition of ATP and dATP by a common site on the enzyme.	2'-deoxyadenosine triphosphate	130-134	DNA nucleotidylexotransferase	Homo sapiens	39-59
53071-7	1975	The apparent Km values for dTTP, dATP, dCTP, and dGTP were 0.71, 0.75, 0.42, and 0.39 muM, respectively.	2'-deoxyadenosine triphosphate	33-37	latexin	Homo sapiens	86-89
227649-5	1978	Studies of these cells provide evidence supporting both cyclic AMP- and dATP-mediated immunosuppressive mechanisms in ADA--SCID.	2'-deoxyadenosine triphosphate	72-76	adenosine deaminase	Homo sapiens	118-121
272665-6	1978	We propose that deoxyadenosine, a substrate of adenosine deaminase, is the potentially toxic substrate in adenosine deaminase deficiency, and that the mediator of the toxic effect is dATP, a recognized potent inhibitor of ribonucleotide reductase.	2'-deoxyadenosine triphosphate	183-187	adenosine deaminase	Homo sapiens	47-66
600797-2	1977	The two-step procedure involves the chemical synthesis of the mononucleotide followed by its enzymic conversion to the triphosphate with myokinase (EC 2.7.4.3) and pyruvate kinase (EC 2.7.1.40) in the presence of trace amounts of dATP or ATP to prime the reaction.	2'-deoxyadenosine triphosphate	230-234	adenylate kinase 1	Homo sapiens	137-146
147874-2	1978	At or near a fork in duplex DNA, rep ATPase action is different from what it is on DNA lacking secondary structure (single-stranded): (i) Km for ATP is lower, (ii) specificity is for ATP and dATP with no action on other nucleoside triphosphates, (iii) sensitivity to certain ATP analogs is reduced, (iv) presence of a DNA-nicking enzyme (e.g. cistron A protein induced by phiX174) is required, and (v) Escherichia coli DNA binding protein facilitates rather than inhibits.	2'-deoxyadenosine triphosphate	191-195	replication protein	Escherichia coli	33-36
4541475-2	1973	Thymidine, deoxyguanosine, and deoxycytidine kinase activities were found to be optimal with deoxyadenosine triphosphate as the phosphoryl donor, whereas deoxycytidine triphosphate was the optimal donor for deoxyadenosine kinase activity.	2'-deoxyadenosine triphosphate	93-120	deoxycytidine kinase	Homo sapiens	31-51
33132160-5	2021	This allows Apaf-1 to bind dATP or ATP and to form the apoptosome, which activates caspase-9.	2'-deoxyadenosine triphosphate	27-31	apoptotic peptidase activating factor 1	Homo sapiens	12-18
34056415-11	2021	The C-terminal truncated DDX3X investigated here hydrolyzes only cytidine triphosphate (CTP) in the absence of RNA and CTP, adenosine triphosphate (ATP), and deoxyribose adenosine triphosphate (dATP) in the presence of RNA.	2'-deoxyadenosine triphosphate	194-198	DEAD-box helicase 3 X-linked	Homo sapiens	25-30
4536970-2	1972	Methotrexate caused a fall in the dTTP pool ranging from 38% to 88% and a rise in the dATP pool ranging from 24% to 185%.A rise in the free intracellular pool of dATP is thought to inhibit both rubonucleotide reduction and polynucleotide ligase, an enzyme concerned in DNA synthesis and repair.	2'-deoxyadenosine triphosphate	162-166	DNA ligase 4	Homo sapiens	223-244
33132160-5	2021	This allows Apaf-1 to bind dATP or ATP and to form the apoptosome, which activates caspase-9.	2'-deoxyadenosine triphosphate	27-31	caspase 9	Homo sapiens	83-92
32787210-1	2020	A unique member of the family of cobalamin (Cbl)-dependent radical S-adenosylmethionine (SAM) enzymes, OxsB, catalyzes the ring constriction of deoxyadenosine triphosphate (dATP) to the base oxetane aldehyde phosphate, a crucial precursor for oxetanocin A (OXT-A), which is an antitumor, antiviral, and antibacterial compound.	2'-deoxyadenosine triphosphate	144-171	oxytocin/neurophysin I prepropeptide	Homo sapiens	257-260
33135886-7	2020	In sum, our results suggest a model wherein dimeric SAMHD1 exists as a "hold state" in the cytosol, ready to be activated by dATP concentrations, where the "tunability" of this activation is further regulated by the redox state of the enzyme.	2'-deoxyadenosine triphosphate	125-129	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	52-58
32787210-1	2020	A unique member of the family of cobalamin (Cbl)-dependent radical S-adenosylmethionine (SAM) enzymes, OxsB, catalyzes the ring constriction of deoxyadenosine triphosphate (dATP) to the base oxetane aldehyde phosphate, a crucial precursor for oxetanocin A (OXT-A), which is an antitumor, antiviral, and antibacterial compound.	2'-deoxyadenosine triphosphate	173-177	oxytocin/neurophysin I prepropeptide	Homo sapiens	257-260
32685845-7	2020	Steady-state and end-point activity assays, in tandem with mass-spectrometric analyses, reveal that the observed hydrolysis of all alleged HBx substrates, ATP, dATP, and GTP, is contingent on the presence of the GroEL chaperone, which preferentially copurifies as a contaminant with GST-HBx and MBP-HBx.	2'-deoxyadenosine triphosphate	160-164	X protein	Hepatitis B virus	139-142
32685845-7	2020	Steady-state and end-point activity assays, in tandem with mass-spectrometric analyses, reveal that the observed hydrolysis of all alleged HBx substrates, ATP, dATP, and GTP, is contingent on the presence of the GroEL chaperone, which preferentially copurifies as a contaminant with GST-HBx and MBP-HBx.	2'-deoxyadenosine triphosphate	160-164	heat shock protein family D (Hsp60) member 1	Homo sapiens	212-217
32144205-3	2020	We here show that MTH1 efficiently catalyzes the hydrolysis of N6-methyl-dATP to N6-methyl-dAMP and further report that N6-methylation of dATP drastically increases the MTH1 activity.	2'-deoxyadenosine triphosphate	73-77	nudix hydrolase 1	Homo sapiens	18-22
32213600-8	2020	Steady-state kinetic analysis of reverse transcription and RNA primer extension showed that hpol eta favors the addition of dATP and dGTP opposite 1,N 6-εrA.	2'-deoxyadenosine triphosphate	124-128	endothelin receptor type A	Homo sapiens	97-100
32144205-3	2020	We here show that MTH1 efficiently catalyzes the hydrolysis of N6-methyl-dATP to N6-methyl-dAMP and further report that N6-methylation of dATP drastically increases the MTH1 activity.	2'-deoxyadenosine triphosphate	73-77	nudix hydrolase 1	Homo sapiens	169-173
31296733-6	2019	In cells, GTP and dATP are the likely physiological activators of two adjacent allosteric sites, AL1 (GTP) and AL2 (dATP), that bridge monomer-monomer interfaces to stabilise the protein homotetramer.	2'-deoxyadenosine triphosphate	18-22	ephrin A5	Homo sapiens	97-100
32039434-2	2020	Cisplatin has been shown to predominantly induce G to T mutations and Pt-GG permits significant misincorporation of dATP by human DNA polymerase beta (polbeta).	2'-deoxyadenosine triphosphate	116-120	DNA polymerase beta	Homo sapiens	130-149
31296733-6	2019	In cells, GTP and dATP are the likely physiological activators of two adjacent allosteric sites, AL1 (GTP) and AL2 (dATP), that bridge monomer-monomer interfaces to stabilise the protein homotetramer.	2'-deoxyadenosine triphosphate	116-120	ephrin A5	Homo sapiens	97-100
29440226-5	2018	Converting the first nucleotide of the repeat synthesized from dG to dA through the telomerase template mutation, hTR-51U, correspondingly shifts telomerase repeat addition activity stimulation to dATP-dependent.	2'-deoxyadenosine triphosphate	197-201	telomerase RNA component	Homo sapiens	114-117
31286773-8	2019	The already low nucleotide incorporation fidelity of hPolkappa was further decreased by 10-fold during lesion bypass, and thus, incorrect nucleotides, especially dATP, were incorporated opposite dGC8-N-ABA with comparable efficiencies as correct dCTP.	2'-deoxyadenosine triphosphate	162-166	DNA polymerase lambda	Homo sapiens	53-62
31175919-11	2019	The Ppn1 hydrolyzed dATP, while Ppx1 did not.	2'-deoxyadenosine triphosphate	20-24	endopolyphosphatase	Saccharomyces cerevisiae S288C	4-8
29968274-1	2018	A deoxyadenosine triphosphate (dATP) analogue for DNA labeling was synthesized with the 1-methylcyclopropene (1MCP) group at the 7-position of 7-deaza-2"-deoxyadenosine and applied for primer extension experiments.	2'-deoxyadenosine triphosphate	2-29	CD46 molecule	Homo sapiens	111-114
29968274-1	2018	A deoxyadenosine triphosphate (dATP) analogue for DNA labeling was synthesized with the 1-methylcyclopropene (1MCP) group at the 7-position of 7-deaza-2"-deoxyadenosine and applied for primer extension experiments.	2'-deoxyadenosine triphosphate	31-35	CD46 molecule	Homo sapiens	111-114
29968274-2	2018	The real-time kinetic data reveals that this 1MCP-modified dATP analogue is incorporated into DNA much faster than that of the similarly 1MCP-modified deoxyuridine triphosphate (dUTP) analogue.	2'-deoxyadenosine triphosphate	59-63	CD46 molecule	Homo sapiens	46-49
31110001-1	2019	The naturally occurring nucleotide 2-deoxy-adenosine 5"-triphosphate (dATP) can be used by cardiac muscle as an alternative energy substrate for myosin chemomechanical activity.	2'-deoxyadenosine triphosphate	35-68	myosin heavy chain 14	Homo sapiens	145-151
31110001-1	2019	The naturally occurring nucleotide 2-deoxy-adenosine 5"-triphosphate (dATP) can be used by cardiac muscle as an alternative energy substrate for myosin chemomechanical activity.	2'-deoxyadenosine triphosphate	70-74	myosin heavy chain 14	Homo sapiens	145-151
31110001-4	2019	Exploiting dATP as a molecular probe, we assess how small changes in myosin structure translate to electrostatic-based changes in sarcomere function to augment contractility in cardiac muscle.	2'-deoxyadenosine triphosphate	11-15	myosin heavy chain 14	Homo sapiens	69-75
31110001-8	2019	The dATP-mediated structural alterations in myosin reported here may provide insight into an improved criterion for the design or selection of small molecules to be developed as therapeutic agents to treat systolic dysfunction.	2'-deoxyadenosine triphosphate	4-8	myosin heavy chain 14	Homo sapiens	44-50
29905846-12	2018	Molecular simulations of the 11-mer peptide-dC cross-links bound to human polymerases eta and kappa revealed that the peptide fits well on the DNA major groove side, and the modified dC forms a stable mismatch with incoming dATP via wobble base pairing in the polymerase active site.	2'-deoxyadenosine triphosphate	224-228	endothelin receptor type A	Homo sapiens	86-89
29891696-4	2018	Here we used CRISPR-Cas9 mutagenesis to show that phagocyte intoxication involves uptake of dAdo via the human equilibrative nucleoside transporter 1, dAdo conversion to dAMP by deoxycytidine kinase and adenosine kinase, and signaling via subsequent dATP formation to activate caspase-3-induced cell death.	2'-deoxyadenosine triphosphate	250-254	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	111-149
29460780-3	2018	Here, we present a 3.3-A resolution structure by cryo-electron microscopy (EM) of a dATP-inhibited state of human RNR.	2'-deoxyadenosine triphosphate	84-88	nuclear receptor subfamily 2 group E member 3	Homo sapiens	114-117
28684739-8	2017	The variant SdbhKSKIP241-245RVRKS showed higher activity than Dbh on the incorporation of dCTP (correct) and dATP (incorrect) opposite the G (normal) or 8-oxoG(damaged) template base.	2'-deoxyadenosine triphosphate	109-113	dopamine beta-hydroxylase	Homo sapiens	62-65
28735680-6	2017	The rate-limiting enzyme of dNTP synthesis, ribonucleotide reductase, is inhibited by endogenous levels of deoxyATP (dATP) present at fertilization and is activated as dATP is depleted via DNA polymerization.	2'-deoxyadenosine triphosphate	107-115	Ribonucleoside diphosphate reductase small subunit	Drosophila melanogaster	44-68
28735680-6	2017	The rate-limiting enzyme of dNTP synthesis, ribonucleotide reductase, is inhibited by endogenous levels of deoxyATP (dATP) present at fertilization and is activated as dATP is depleted via DNA polymerization.	2'-deoxyadenosine triphosphate	117-121	Ribonucleoside diphosphate reductase small subunit	Drosophila melanogaster	44-68
28735680-6	2017	The rate-limiting enzyme of dNTP synthesis, ribonucleotide reductase, is inhibited by endogenous levels of deoxyATP (dATP) present at fertilization and is activated as dATP is depleted via DNA polymerization.	2'-deoxyadenosine triphosphate	168-172	Ribonucleoside diphosphate reductase small subunit	Drosophila melanogaster	44-68
27592241-4	2017	Subsequently, TdT can catalyze the elongation of the signal probes and formation of many G-quadruplex sequence replicates with the presence of dGTP and dATP at a molar ratio of 6:4.	2'-deoxyadenosine triphosphate	152-156	DNA nucleotidylexotransferase	Homo sapiens	14-17
28097776-3	2017	When 2-deoxy ATP (dATP) is used, it acts as a myosin activator, enhancing cross-bridge binding and cycling.	2'-deoxyadenosine triphosphate	18-22	myosin X	Sus scrofa	46-52
28097776-6	2017	We show with molecular dynamics simulations that the binding of dADP.Pi (dATP hydrolysis products) to myosin alters the structure and dynamics of the nucleotide binding pocket, myosin cleft conformation, and actin binding sites, which collectively yield a myosin conformation that we predict favors weak, electrostatic binding to actin.	2'-deoxyadenosine triphosphate	73-77	myosin X	Sus scrofa	102-108
28097776-6	2017	We show with molecular dynamics simulations that the binding of dADP.Pi (dATP hydrolysis products) to myosin alters the structure and dynamics of the nucleotide binding pocket, myosin cleft conformation, and actin binding sites, which collectively yield a myosin conformation that we predict favors weak, electrostatic binding to actin.	2'-deoxyadenosine triphosphate	73-77	myosin X	Sus scrofa	177-183
28097776-8	2017	These results highlight alterations to myosin that enhance cross-bridge formation and reveal a potential mechanism that may underlie dATP-induced improvements in cardiac function.	2'-deoxyadenosine triphosphate	133-137	myosin X	Sus scrofa	39-45
28036343-8	2016	Results of the elastic net regression showed weak relationships between IL-1Ra and FTC-triphosphate and deoxyadenosine triphosphate exposures, and MIP-1beta, age and TFV-diphosphate exposures.	2'-deoxyadenosine triphosphate	104-131	interleukin 1 receptor antagonist	Homo sapiens	72-78
27471153-6	2016	BbvCI, output DNA existed in hybridization complex was released from electrode and participated in the next hybridization process, accompanying with the cleave of HP2 to expose substantial 3"-OH group, which could be extended into a long ssDNA nanotail with the aid of TdT and deoxyadenosine triphosphate (dATP).	2'-deoxyadenosine triphosphate	277-304	DNA nucleotidylexotransferase	Homo sapiens	269-272
27471153-6	2016	BbvCI, output DNA existed in hybridization complex was released from electrode and participated in the next hybridization process, accompanying with the cleave of HP2 to expose substantial 3"-OH group, which could be extended into a long ssDNA nanotail with the aid of TdT and deoxyadenosine triphosphate (dATP).	2'-deoxyadenosine triphosphate	306-310	DNA nucleotidylexotransferase	Homo sapiens	269-272
26807524-3	2016	The presence of Hg(2+) leads to DNA hybridization, in which complementary DNA was captured onto the biosensor surface, which subsequently catalyzed the addition of deoxynucleotides (dNTP) containing biotinlated 2"-deoxyadenosine 5"-triphosphate (biotin-dATP) by terminal deoxynucleotidyl transferase (TdT).	2'-deoxyadenosine triphosphate	211-244	DNA nucleotidylexotransferase	Homo sapiens	262-299
27809838-9	2016	Its helicase activity is dependent on divalent cations (Cu2+, Mg2+, Ni+2 or Zn+2) and ATP or dATP but is inhibited by high NaCl concentration (>100 mM).	2'-deoxyadenosine triphosphate	93-97	helicase for meiosis 1	Homo sapiens	4-12
27226627-4	2016	In steady-state kinetic analysis, hpol eta preferred to incorporate dATP and dGTP, compared with dTTP.	2'-deoxyadenosine triphosphate	68-72	endothelin receptor type A	Homo sapiens	39-42
26807524-3	2016	The presence of Hg(2+) leads to DNA hybridization, in which complementary DNA was captured onto the biosensor surface, which subsequently catalyzed the addition of deoxynucleotides (dNTP) containing biotinlated 2"-deoxyadenosine 5"-triphosphate (biotin-dATP) by terminal deoxynucleotidyl transferase (TdT).	2'-deoxyadenosine triphosphate	211-244	DNA nucleotidylexotransferase	Homo sapiens	301-304
26862665-6	2016	We found that the second-order mant-dATP binding rate of cTnI-ND mouse cardiac myofibrils was 3-fold faster than that of wild-type myofibrils at low Ca(2+) concentrations.	2'-deoxyadenosine triphosphate	36-40	troponin I, cardiac 3	Mus musculus	57-61
26497964-3	2016	2-Deoxyadenosine triphosphate (dATP) can be used by myosin and is a superior energy substrate over ATP for cross-bridge formation and increased systolic function.	2'-deoxyadenosine triphosphate	0-29	myosin heavy chain 14	Homo sapiens	52-58
26455538-3	2016	D-ATP can be detected from 1 to 25 muM in a linear range and a detection limit (LOD) of 3 muM can be reached.	2'-deoxyadenosine triphosphate	0-5	latexin	Homo sapiens	35-38
26455538-3	2016	D-ATP can be detected from 1 to 25 muM in a linear range and a detection limit (LOD) of 3 muM can be reached.	2'-deoxyadenosine triphosphate	0-5	latexin	Homo sapiens	90-93
26497964-3	2016	2-Deoxyadenosine triphosphate (dATP) can be used by myosin and is a superior energy substrate over ATP for cross-bridge formation and increased systolic function.	2'-deoxyadenosine triphosphate	31-35	myosin heavy chain 14	Homo sapiens	52-58
26497964-13	2016	Our findings suggest that myosin utilization of dATP improves cardiac myofibril contractile properties of naturally occurring DCM canine samples, restoring them to NF levels, without compromising relaxation.	2'-deoxyadenosine triphosphate	48-52	myosin heavy chain 14	Homo sapiens	26-32
26631121-2	2015	Active caspases in dATP-activated lysates are detected by fluorimetry using a tetrapeptide substrate (DEVD) tagged with a fluorophore (AFC), which, when released, produces a real-time readout for caspase-3 and -7 (DEVDase) activity.	2'-deoxyadenosine triphosphate	19-23	caspase 9	Homo sapiens	7-15
26731175-9	2016	Negative associations were observed between p16(INK4a) expression and each of FTC-triphosphate (r=-0.45), deoxyadenosine triphosphate (dATP; r=-0.47) and deoxycytidine triphosphate (dCTP; r=-0.57) AUCs (P-values <0.02).	2'-deoxyadenosine triphosphate	106-133	cyclin dependent kinase inhibitor 2A	Homo sapiens	44-47
26731175-9	2016	Negative associations were observed between p16(INK4a) expression and each of FTC-triphosphate (r=-0.45), deoxyadenosine triphosphate (dATP; r=-0.47) and deoxycytidine triphosphate (dCTP; r=-0.57) AUCs (P-values <0.02).	2'-deoxyadenosine triphosphate	106-133	cyclin dependent kinase inhibitor 2A	Homo sapiens	48-53
26731175-9	2016	Negative associations were observed between p16(INK4a) expression and each of FTC-triphosphate (r=-0.45), deoxyadenosine triphosphate (dATP; r=-0.47) and deoxycytidine triphosphate (dCTP; r=-0.57) AUCs (P-values <0.02).	2'-deoxyadenosine triphosphate	135-139	cyclin dependent kinase inhibitor 2A	Homo sapiens	48-53
26631121-2	2015	Active caspases in dATP-activated lysates are detected by fluorimetry using a tetrapeptide substrate (DEVD) tagged with a fluorophore (AFC), which, when released, produces a real-time readout for caspase-3 and -7 (DEVDase) activity.	2'-deoxyadenosine triphosphate	19-23	caspase 3	Homo sapiens	196-212
26265044-3	2015	As one of the major components of apoptosomes, apoptotic protease activating factor 1 (Apaf-1) facilitates the formation of apoptosomes containing cytochrome c (Cyto-c) and deoxyadenosine triphosphate (dATP).	2'-deoxyadenosine triphosphate	173-200	apoptotic peptidase activating factor 1	Homo sapiens	47-85
26543158-6	2015	Structural comparison with autoinhibited Apaf-1 revealed how dATP binding triggers a set of conformational changes that results in the formation of the apoptosome.	2'-deoxyadenosine triphosphate	61-65	apoptotic peptidase activating factor 1	Homo sapiens	41-47
26265044-3	2015	As one of the major components of apoptosomes, apoptotic protease activating factor 1 (Apaf-1) facilitates the formation of apoptosomes containing cytochrome c (Cyto-c) and deoxyadenosine triphosphate (dATP).	2'-deoxyadenosine triphosphate	202-206	apoptotic peptidase activating factor 1	Homo sapiens	87-93
26265044-3	2015	As one of the major components of apoptosomes, apoptotic protease activating factor 1 (Apaf-1) facilitates the formation of apoptosomes containing cytochrome c (Cyto-c) and deoxyadenosine triphosphate (dATP).	2'-deoxyadenosine triphosphate	173-200	apoptotic peptidase activating factor 1	Homo sapiens	87-93
26265044-3	2015	As one of the major components of apoptosomes, apoptotic protease activating factor 1 (Apaf-1) facilitates the formation of apoptosomes containing cytochrome c (Cyto-c) and deoxyadenosine triphosphate (dATP).	2'-deoxyadenosine triphosphate	202-206	apoptotic peptidase activating factor 1	Homo sapiens	47-85
26100204-0	2015	Kinetics of the ATP and dATP-mediated formation of a functionally-active RecA-ssDNA complex.	2'-deoxyadenosine triphosphate	24-28	RAD51 recombinase	Homo sapiens	73-77
26100204-1	2015	The kinetics of the ATP and dATP-mediated formation of a functionally-active RecA-ssDNA complex were examined by stopped-flow fluorescence spectroscopy, using a modified version of the RecA protein that contains a fluorescent reporter group in the ssDNA binding site.	2'-deoxyadenosine triphosphate	28-32	RAD51 recombinase	Homo sapiens	77-81
26100204-1	2015	The kinetics of the ATP and dATP-mediated formation of a functionally-active RecA-ssDNA complex were examined by stopped-flow fluorescence spectroscopy, using a modified version of the RecA protein that contains a fluorescent reporter group in the ssDNA binding site.	2'-deoxyadenosine triphosphate	28-32	RAD51 recombinase	Homo sapiens	185-189
26100204-2	2015	The results indicated that: i) an active RecA-ssDNA complex was formed more rapidly on dT200 than on dT50 when either ATP or dATP was provided as the nucleotide cofactor, and ii) active complex formation occurred more rapidly with dATP than with ATP on either dT50 or dT200.	2'-deoxyadenosine triphosphate	125-129	RAD51 recombinase	Homo sapiens	41-45
26100204-2	2015	The results indicated that: i) an active RecA-ssDNA complex was formed more rapidly on dT200 than on dT50 when either ATP or dATP was provided as the nucleotide cofactor, and ii) active complex formation occurred more rapidly with dATP than with ATP on either dT50 or dT200.	2'-deoxyadenosine triphosphate	231-235	RAD51 recombinase	Homo sapiens	41-45
26100204-3	2015	The dependence on both the identity of the nucleotide cofactor and the length of the ssDNA effector indicated that active complex formation occurs by a cooperative mechanism and that dATP is more effective than ATP in mediating the interactions between RecA monomers that drive this process.	2'-deoxyadenosine triphosphate	183-187	RAD51 recombinase	Homo sapiens	253-257
26100204-4	2015	Interestingly, the time courses of dATP-mediated active complex formation were closely similar to those that were obtained with ATPgammaS, an effectively non-hydrolyzable ATP analog that strongly stabilizes the active conformation of the RecA-ssDNA complex.	2'-deoxyadenosine triphosphate	35-39	RAD51 recombinase	Homo sapiens	238-242
26100204-5	2015	These results provide mechanistic insight into the enhanced ssDNA binding and DNA strand exchange activities that are observed when dATP is provided in place of ATP in RecA biochemical assays.	2'-deoxyadenosine triphosphate	132-136	RAD51 recombinase	Homo sapiens	168-172
25288794-3	2014	Here, we present the crystal structures of SAMHD1 catalytic core (residues 113-626) tetramers, complexed with mixtures of nucleotides, including dGTP/dATP, dGTP/dCTP, dGTP/dTTP, and dGTP/dUTP.	2'-deoxyadenosine triphosphate	150-154	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	43-49
25876005-0	2015	Ribonucleotide reductase-mediated increase in dATP improves cardiac performance via myosin activation in a large animal model of heart failure.	2'-deoxyadenosine triphosphate	46-50	myosin heavy chain 14	Homo sapiens	84-90
25749797-10	2015	Upon T cell receptor activation, the levels of all analytes, with the notable exceptions of deoxyadenosine triphosphate and deoxyguanosine triphosphate, were found to be elevated in CD4 T cells.	2'-deoxyadenosine triphosphate	92-119	CD4 molecule	Homo sapiens	182-185
25875700-2	2015	Deficiency of the purine salvage enzyme ADA leads to the build-up of the toxic metabolites, deoxyadenosine triphosphate and deoxyadenosine.	2'-deoxyadenosine triphosphate	92-119	adenosine deaminase	Homo sapiens	40-43
25666608-10	2015	In x-ray structures of hpol eta with a non-hydrolyzable analog of dATP or dGTP opposite an abasic site, H-bonding was observed between the phosphate 5" to the abasic site and water H-bonded to N1 and N6 of A and N1 and O6 of G nucleoside triphosphate analogs, offering an explanation for what appears to be a "purine rule."	2'-deoxyadenosine triphosphate	66-70	endothelin receptor type A	Homo sapiens	28-31
25288794-5	2014	In addition, we present biochemical analyses of GTP-induced SAMHD1 full-length tetramerization and the structure of SAMHD1 catalytic core tetramer in complex with GTP/dATP, revealing the structural basis of GTP-mediated SAMHD1 activation.	2'-deoxyadenosine triphosphate	167-171	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	116-122
25288794-5	2014	In addition, we present biochemical analyses of GTP-induced SAMHD1 full-length tetramerization and the structure of SAMHD1 catalytic core tetramer in complex with GTP/dATP, revealing the structural basis of GTP-mediated SAMHD1 activation.	2'-deoxyadenosine triphosphate	167-171	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	116-122
25367944-1	2014	IRBIT inhibits ribonucleotide reductase (RNR) by stabilizing dATP binding to the RNR activity site.	2'-deoxyadenosine triphosphate	61-65	adenosylhomocysteinase like 1	Homo sapiens	0-5
24759104-8	2014	That hpol eta discriminates against dATP exclusively at the insertion stage is confirmed by structures of ternary complexes that allow visualization of the extension step.	2'-deoxyadenosine triphosphate	36-40	endothelin receptor type A	Homo sapiens	10-13
24828500-11	2014	The apparent Km for dATP at site 2 is ~10 mum for mouse and 1 mum for human SAMHD1, for dTTP the corresponding values are 50 and 2 mum.	2'-deoxyadenosine triphosphate	20-24	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	76-82
25237103-4	2014	Here, we show that the metazoan protein IRBIT forms a deoxyadenosine triphosphate (dATP)-dependent complex with RNR, which stabilizes dATP in the activity site of RNR and thus inhibits the enzyme.	2'-deoxyadenosine triphosphate	54-81	adenosylhomocysteinase like 1	Homo sapiens	40-45
25237103-4	2014	Here, we show that the metazoan protein IRBIT forms a deoxyadenosine triphosphate (dATP)-dependent complex with RNR, which stabilizes dATP in the activity site of RNR and thus inhibits the enzyme.	2'-deoxyadenosine triphosphate	83-87	adenosylhomocysteinase like 1	Homo sapiens	40-45
25237103-4	2014	Here, we show that the metazoan protein IRBIT forms a deoxyadenosine triphosphate (dATP)-dependent complex with RNR, which stabilizes dATP in the activity site of RNR and thus inhibits the enzyme.	2'-deoxyadenosine triphosphate	134-138	adenosylhomocysteinase like 1	Homo sapiens	40-45
24987139-2	2014	In this protocol, cytosolic extracts prepared from cell culture are incubated with cytochrome c and adenosine triphosphate (dATP), leading to the oligomerization of apoptotic protease activating factor-1 (APAF-1) and the formation of the apoptosome.	2'-deoxyadenosine triphosphate	124-128	apoptotic peptidase activating factor 1	Homo sapiens	165-203
24987139-2	2014	In this protocol, cytosolic extracts prepared from cell culture are incubated with cytochrome c and adenosine triphosphate (dATP), leading to the oligomerization of apoptotic protease activating factor-1 (APAF-1) and the formation of the apoptosome.	2'-deoxyadenosine triphosphate	124-128	apoptotic peptidase activating factor 1	Homo sapiens	205-211
24626292-3	2014	Treatment of cytosol samples with cytochrome c (cyt-c) and dATP induced proteolytic processing of procaspase-9 to caspase-9, which was followed by procaspase-3 processing to caspase-3, and by generation of caspase-3-like activity in 5 of 7 studied NSCLC cell lines.	2'-deoxyadenosine triphosphate	59-63	caspase 9	Homo sapiens	101-110
24626292-3	2014	Treatment of cytosol samples with cytochrome c (cyt-c) and dATP induced proteolytic processing of procaspase-9 to caspase-9, which was followed by procaspase-3 processing to caspase-3, and by generation of caspase-3-like activity in 5 of 7 studied NSCLC cell lines.	2'-deoxyadenosine triphosphate	59-63	caspase 3	Homo sapiens	147-159
24626292-10	2014	Taken together, the present study provides evidence that the apoptosome apparatus is functional in the majority of NSCLCs and that its sensitivity to the (cyt-c + dATP)-mediated activation is often enhanced in NSCLCs compared to lungs.	2'-deoxyadenosine triphosphate	163-167	cytochrome c, somatic	Homo sapiens	155-160
24626292-3	2014	Treatment of cytosol samples with cytochrome c (cyt-c) and dATP induced proteolytic processing of procaspase-9 to caspase-9, which was followed by procaspase-3 processing to caspase-3, and by generation of caspase-3-like activity in 5 of 7 studied NSCLC cell lines.	2'-deoxyadenosine triphosphate	59-63	caspase 3	Homo sapiens	150-159
24626292-3	2014	Treatment of cytosol samples with cytochrome c (cyt-c) and dATP induced proteolytic processing of procaspase-9 to caspase-9, which was followed by procaspase-3 processing to caspase-3, and by generation of caspase-3-like activity in 5 of 7 studied NSCLC cell lines.	2'-deoxyadenosine triphosphate	59-63	caspase 3	Homo sapiens	174-183
24626292-4	2014	Further analysis demonstrated formation of high-Mr Apaf-1 complexes associated with cleaved caspase-9 in the (cyt-c + dATP)-responsive COLO-699 and CALU-1 cells.	2'-deoxyadenosine triphosphate	118-122	apoptotic peptidase activating factor 1	Homo sapiens	51-57
24626292-4	2014	Further analysis demonstrated formation of high-Mr Apaf-1 complexes associated with cleaved caspase-9 in the (cyt-c + dATP)-responsive COLO-699 and CALU-1 cells.	2'-deoxyadenosine triphosphate	118-122	caspase 9	Homo sapiens	92-101
24626292-4	2014	Further analysis demonstrated formation of high-Mr Apaf-1 complexes associated with cleaved caspase-9 in the (cyt-c + dATP)-responsive COLO-699 and CALU-1 cells.	2'-deoxyadenosine triphosphate	118-122	cytochrome c, somatic	Homo sapiens	110-115
24626292-6	2014	Thermal pre-treatment of cell-free cytosols in the absence of exogenous cyt-c and dATP lead to formation of Apaf-1 aggregates, unable to recruit and activate procaspase-9 in the presence of cyt-c and dATP, and to generate caspase-3-like activity.	2'-deoxyadenosine triphosphate	82-86	apoptotic peptidase activating factor 1	Homo sapiens	108-114
24626292-7	2014	Further studies showed that the treatment with cyt-c and dATP induced a substantially higher increase of caspase-3-like activity in cytosol samples from NSCLC tumours compared to matched lungs.	2'-deoxyadenosine triphosphate	57-61	caspase 3	Homo sapiens	105-114
23267011-9	2013	In contrast to wild-type pol beta, the ternary complex of the R283K mutant with an incoming dATP-analogue and templating 8-oxoG resembles a G-A mismatched structure with 8-oxoG adopting an anti-conformation.	2'-deoxyadenosine triphosphate	92-96	DNA polymerase beta	Homo sapiens	25-33
24148759-2	2014	Although DmTpc1 has a low affinity for model [Pt(dien)(N7-5"-dGTP)] and cis-[Pt(NH3)2(py)(N7-5"-dGTP)] compared to dATP it"s well known that DNA platination level of few metal atoms per double-stranded molecule may account for the pharmacological activity of platinum based antitumor drugs.	2'-deoxyadenosine triphosphate	115-119	Thiamine pyrophosphate carrier protein 1	Drosophila melanogaster	9-15
24097443-6	2014	These Pols successfully synthesize opposite 3meC; Pol iota preferentially misincorporates dTTP and Pol eta dATP.	2'-deoxyadenosine triphosphate	107-111	endothelin receptor type A	Homo sapiens	103-106
23630267-3	2013	Overwhelming evidence suggests that DNA polymerase eta (Pol eta) is responsible for converting the WA motif to WG by misincorporating dGTP opposite the templating T. To elucidate the molecular mechanism, crystal structures and kinetics of human Pol eta substituting dGTP for dATP in four sequence contexts, TA, AA, GA, and CA, have been determined and compared.	2'-deoxyadenosine triphosphate	275-279	DNA polymerase eta	Homo sapiens	36-54
23392349-6	2013	This study demonstrated that mice lacking ADA developed COPD manifestations in association with elevated dAdo and dATP levels and increased apoptosis in the lung.	2'-deoxyadenosine triphosphate	114-118	adenosine deaminase	Mus musculus	42-45
22062585-8	2012	Using purified NOD1 protein for nucleotide binding studies by the Fluorescence Polarization Assay (FPA) method, we determined that NOD1 binds preferentially to ATP over ADP and AMP or dATP.	2'-deoxyadenosine triphosphate	184-188	nucleotide binding oligomerization domain containing 1	Homo sapiens	15-19
23717197-2	2013	Here we analyze molecular dynamics simulations of DNA polymerase mu (pol mu) bound to different non-cognate incoming nucleotides including A:dCTP, A:dGTP, A(syn):dGTP, A:dATP, A(syn):dATP, T:dCTP, and T:dGTP to study the structure-function relationships involved with aberrant base pairs in the conformational pathway; while a pol mu complex with the A:dTTP base pair is available, no solved non-cognate structures are available.	2'-deoxyadenosine triphosphate	170-174	DNA polymerase mu	Homo sapiens	50-67
23717197-2	2013	Here we analyze molecular dynamics simulations of DNA polymerase mu (pol mu) bound to different non-cognate incoming nucleotides including A:dCTP, A:dGTP, A(syn):dGTP, A:dATP, A(syn):dATP, T:dCTP, and T:dGTP to study the structure-function relationships involved with aberrant base pairs in the conformational pathway; while a pol mu complex with the A:dTTP base pair is available, no solved non-cognate structures are available.	2'-deoxyadenosine triphosphate	170-174	DNA polymerase mu	Homo sapiens	69-75
23717197-2	2013	Here we analyze molecular dynamics simulations of DNA polymerase mu (pol mu) bound to different non-cognate incoming nucleotides including A:dCTP, A:dGTP, A(syn):dGTP, A:dATP, A(syn):dATP, T:dCTP, and T:dGTP to study the structure-function relationships involved with aberrant base pairs in the conformational pathway; while a pol mu complex with the A:dTTP base pair is available, no solved non-cognate structures are available.	2'-deoxyadenosine triphosphate	183-187	DNA polymerase mu	Homo sapiens	50-67
23717197-2	2013	Here we analyze molecular dynamics simulations of DNA polymerase mu (pol mu) bound to different non-cognate incoming nucleotides including A:dCTP, A:dGTP, A(syn):dGTP, A:dATP, A(syn):dATP, T:dCTP, and T:dGTP to study the structure-function relationships involved with aberrant base pairs in the conformational pathway; while a pol mu complex with the A:dTTP base pair is available, no solved non-cognate structures are available.	2'-deoxyadenosine triphosphate	183-187	DNA polymerase mu	Homo sapiens	69-75
23717197-8	2013	Taken together, our studies propose the following order for difficulty of non-cognate system insertions by pol mu: T:dGTP<A(syn):dATP<T:dCTP<A:dGTP<A(syn):dGTP<A:dCTP<A:dATP.	2'-deoxyadenosine triphosphate	132-136	DNA polymerase mu	Homo sapiens	107-113
23717197-8	2013	Taken together, our studies propose the following order for difficulty of non-cognate system insertions by pol mu: T:dGTP<A(syn):dATP<T:dCTP<A:dGTP<A(syn):dGTP<A:dCTP<A:dATP.	2'-deoxyadenosine triphosphate	132-136	synemin	Homo sapiens	127-130
23717197-8	2013	Taken together, our studies propose the following order for difficulty of non-cognate system insertions by pol mu: T:dGTP<A(syn):dATP<T:dCTP<A:dGTP<A(syn):dGTP<A:dCTP<A:dATP.	2'-deoxyadenosine triphosphate	132-136	synemin	Homo sapiens	162-165
23717197-8	2013	Taken together, our studies propose the following order for difficulty of non-cognate system insertions by pol mu: T:dGTP<A(syn):dATP<T:dCTP<A:dGTP<A(syn):dGTP<A:dCTP<A:dATP.	2'-deoxyadenosine triphosphate	187-191	DNA polymerase mu	Homo sapiens	107-113
23717197-8	2013	Taken together, our studies propose the following order for difficulty of non-cognate system insertions by pol mu: T:dGTP<A(syn):dATP<T:dCTP<A:dGTP<A(syn):dGTP<A:dCTP<A:dATP.	2'-deoxyadenosine triphosphate	187-191	synemin	Homo sapiens	127-130
23717197-8	2013	Taken together, our studies propose the following order for difficulty of non-cognate system insertions by pol mu: T:dGTP<A(syn):dATP<T:dCTP<A:dGTP<A(syn):dGTP<A:dCTP<A:dATP.	2'-deoxyadenosine triphosphate	187-191	synemin	Homo sapiens	162-165
22178760-6	2012	The DNA base excision repair enzyme DNA polymerase (pol) beta is presented with gap-filling synthesis opposite 8-oxoG during repair and has similar insertion efficiencies for dCTP and dATP.	2'-deoxyadenosine triphosphate	184-188	DNA polymerase beta	Homo sapiens	40-61
24217394-4	2013	Here we report the 1.8-A crystal structure of homotetrameric SAMHD1 in complex with the allosteric activator and substrate dGTP/dATP.	2'-deoxyadenosine triphosphate	128-132	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	61-67
22062585-8	2012	Using purified NOD1 protein for nucleotide binding studies by the Fluorescence Polarization Assay (FPA) method, we determined that NOD1 binds preferentially to ATP over ADP and AMP or dATP.	2'-deoxyadenosine triphosphate	184-188	nucleotide binding oligomerization domain containing 1	Homo sapiens	131-135
21463108-6	2011	Both dATP and CdATP cause an initial accumulation of DNA strand breaks in lymphocytes and this results in the activation of p53, the release of cytochrome c from mitochondria, and apoptosis.	2'-deoxyadenosine triphosphate	5-9	tumor protein p53	Homo sapiens	124-127
21739967-8	2011	Compared to the dCTP G base pair, the dATP G mismatch has fewer GSA configurations with short distances between O(nuc) and P(alpha) atoms and between the oxygen in the scissile P-O bond (O(lg)) and the nearest structural water.	2'-deoxyadenosine triphosphate	38-42	nucleobindin 1	Homo sapiens	114-117
23300702-6	2012	Our results further imply that, in addition to the dATP increase by dCK activation in tumor cells, dCK may also involve in the apoptotic regulation.	2'-deoxyadenosine triphosphate	51-55	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	68-71
21925507-2	2011	In the current study we hypothesized that cellular [dATP] could be increased by viral-mediated overexpression of the ribonucleotide reductase (Rrm1 and Rrm2) complex, which would increase contractility of adult rat cardiomyocytes.	2'-deoxyadenosine triphosphate	52-56	ribonucleotide reductase catalytic subunit M1	Rattus norvegicus	143-147
21925507-2	2011	In the current study we hypothesized that cellular [dATP] could be increased by viral-mediated overexpression of the ribonucleotide reductase (Rrm1 and Rrm2) complex, which would increase contractility of adult rat cardiomyocytes.	2'-deoxyadenosine triphosphate	52-56	ribonucleotide reductase regulatory subunit M2	Rattus norvegicus	152-156
21628579-2	2011	alpha binds NDP substrates (CDP, UDP, ADP, and GDP, C site) as well as ATP and dNTPs (dATP, dGTP, TTP) allosteric effectors that control enzyme activity (A site) and substrate specificity (S site).	2'-deoxyadenosine triphosphate	86-90	norrin cystine knot growth factor NDP	Homo sapiens	12-15
21628579-2	2011	alpha binds NDP substrates (CDP, UDP, ADP, and GDP, C site) as well as ATP and dNTPs (dATP, dGTP, TTP) allosteric effectors that control enzyme activity (A site) and substrate specificity (S site).	2'-deoxyadenosine triphosphate	86-90	cut like homeobox 1	Homo sapiens	28-31
21463108-6	2011	Both dATP and CdATP cause an initial accumulation of DNA strand breaks in lymphocytes and this results in the activation of p53, the release of cytochrome c from mitochondria, and apoptosis.	2'-deoxyadenosine triphosphate	5-9	cytochrome c, somatic	Homo sapiens	144-156
21304950-2	2011	We recently proposed a method of detection of Pol iota activity in animal cell extracts, based on primer extension opposite the template T with a high concentration of only two nucleotides, dGTP and dATP (incorporation of "G" versus "A" method of Gening, abbreviated as "misGvA").	2'-deoxyadenosine triphosphate	199-203	DNA polymerase mu	Homo sapiens	46-54
21790018-0	2011	[Changing of filamentation dynamics of RecA protein, induced by D112R amino acid substitution or ATP to dATP replacement, results in filament steadiness TO THE RecX protein action].	2'-deoxyadenosine triphosphate	104-108	RAD51 recombinase	Homo sapiens	39-43
21790018-6	2011	On the other hand, after the replacement of ATP by dATP, the wild-type RecA protein, changing the dynamics of filamentation on ssDNA, also becomes more resistant to RecX.	2'-deoxyadenosine triphosphate	51-55	RAD51 recombinase	Homo sapiens	71-75
21193798-4	2011	RecA K72R filaments do not form in the presence of ATP but do so when dATP is provided.	2'-deoxyadenosine triphosphate	70-74	RAD51 recombinase	Homo sapiens	0-4
21336276-3	2011	RR is allosterically regulated by its activator ATP and its inhibitor dATP, which regulate RR activity by inducing oligomerization of RR1.	2'-deoxyadenosine triphosphate	70-74	ribonucleotide reductase catalytic subunit M1	Homo sapiens	134-137
21336276-4	2011	Here, we report the first X-ray structures of human RR1 bound to TTP alone, dATP alone, TTP-GDP, TTP-ATP, and TTP-dATP.	2'-deoxyadenosine triphosphate	76-80	ribonucleotide reductase catalytic subunit M1	Homo sapiens	52-55
21336276-6	2011	At physiological dATP concentrations, RR1 forms inactive hexamers.	2'-deoxyadenosine triphosphate	17-21	ribonucleotide reductase catalytic subunit M1	Homo sapiens	38-41
19759017-9	2009	The crystallographic structures of pol beta bound to gapped DNA with an AP site analog (tertrahydrofuran) in the gap (binary complex) and with an incoming nonhydrolyzable dATP analog (ternary complex) were solved.	2'-deoxyadenosine triphosphate	171-175	DNA polymerase beta	Homo sapiens	35-43
20406820-6	2010	Here we show that 2"-deoxy-ATP (dATP), but not 3"-deoxy-ATP, increases the activity of G551D-CFTR by approximately 8-fold.	2'-deoxyadenosine triphosphate	32-36	CF transmembrane conductance regulator	Homo sapiens	93-97
20118258-5	2010	ORF735 existed in solution as a salt-stable dimer and was capable of assembling into a salt-sensitive oligomer that was significantly larger than a hexamer in the presence of a divalent cation (Mg(2+)) and an adenine nucleotide (ATP, dATP, or ADP) or its analog (ATPgammaS or AMPPNP).	2'-deoxyadenosine triphosphate	234-238	hypothetical protein	Saccharolobus solfataricus P2	0-6
21297999-2	2011	This process can be recapitulated using recombinant Apaf-1 and CC in the presence of nucleotides ATP or dATP [(d)ATP] or using fresh cytosol and CC without the need of exogenous nucleotides.	2'-deoxyadenosine triphosphate	104-108	apoptotic peptidase activating factor 1	Homo sapiens	52-58
21297999-2	2011	This process can be recapitulated using recombinant Apaf-1 and CC in the presence of nucleotides ATP or dATP [(d)ATP] or using fresh cytosol and CC without the need of exogenous nucleotides.	2'-deoxyadenosine triphosphate	104-108	cytochrome c, somatic	Homo sapiens	63-65
21220123-6	2011	In particular, Dark has "lost" a loop in the nucleotide-binding pocket, which opens a path for possible dATP exchange in the apoptosome.	2'-deoxyadenosine triphosphate	104-108	dk	Drosophila melanogaster	15-19
19801675-2	2009	Binding of mitochondrially released cytochrome c and of dATP or ATP to Apaf-1 induces the formation of the heptameric apoptosome complex, which in turn activates procaspase-9.	2'-deoxyadenosine triphosphate	56-60	apoptotic peptidase activating factor 1	Homo sapiens	71-77
19542228-3	2009	Unlike its archaeal homolog Dpo4, hPol kappa bypasses this lesion in an error-prone fashion by inserting mainly dATP.	2'-deoxyadenosine triphosphate	112-116	DNA polymerase lambda	Homo sapiens	34-44
19383546-1	2009	The apoptotic protease activating factor (Apaf-1) is a protein that binds to cytochrome c, and in the presence of dATP/ATP oligomerizes to assume the role of an adaptor platform for activating the caspase-9 zymogen.	2'-deoxyadenosine triphosphate	114-118	apoptotic peptidase activating factor 1	Homo sapiens	42-48
19383546-1	2009	The apoptotic protease activating factor (Apaf-1) is a protein that binds to cytochrome c, and in the presence of dATP/ATP oligomerizes to assume the role of an adaptor platform for activating the caspase-9 zymogen.	2'-deoxyadenosine triphosphate	114-118	caspase 9	Homo sapiens	197-206
19542228-5	2009	Crystal structures of ternary hPol kappa complexes with adducted template-primer DNA reveal non-productive (dGTP and dATP) alignments of incoming nucleotide and 8-oxoG.	2'-deoxyadenosine triphosphate	117-121	DNA polymerase lambda	Homo sapiens	30-40
19492058-0	2009	Structure of human DNA polymerase kappa inserting dATP opposite an 8-OxoG DNA lesion.	2'-deoxyadenosine triphosphate	50-54	DNA polymerase kappa	Homo sapiens	19-39
19580325-6	2009	Consistent with these results, both DNA polymerases efficiently polymerize dGTP and dATP when tC and tCo are in the template strand.	2'-deoxyadenosine triphosphate	84-88	TCO	Homo sapiens	101-104
19325570-2	2009	The hierarchical ordering of caspases has been clearly established using dATP-activated cell lysates to model the intrinsic pathway induced by initial mitochondrial perturbation.	2'-deoxyadenosine triphosphate	73-77	caspase 2	Homo sapiens	29-37
19419960-8	2009	As a consequence, RecA-RFP is proficient for DNA strand exchange with dATP or at lower pH.	2'-deoxyadenosine triphosphate	70-74	RAD51 recombinase	Homo sapiens	18-22
19419960-8	2009	As a consequence, RecA-RFP is proficient for DNA strand exchange with dATP or at lower pH.	2'-deoxyadenosine triphosphate	70-74	tripartite motif containing 27	Homo sapiens	23-26
19492058-3	2009	To understand the basis of Polkappa"s preference for insertion of an A opposite 8-oxoG lesion, we have solved the structure of Polkappa in ternary complex with a template-primer presenting 8-oxoG in the active site and with dATP as the incoming nucleotide.	2'-deoxyadenosine triphosphate	224-228	DNA polymerase lambda	Homo sapiens	27-35
19492058-3	2009	To understand the basis of Polkappa"s preference for insertion of an A opposite 8-oxoG lesion, we have solved the structure of Polkappa in ternary complex with a template-primer presenting 8-oxoG in the active site and with dATP as the incoming nucleotide.	2'-deoxyadenosine triphosphate	224-228	DNA polymerase lambda	Homo sapiens	127-135
19492058-6	2009	There is no steric hindrance to accommodating 8-oxoG in the syn conformation for Hoogsteen base-paring with incoming dATP.	2'-deoxyadenosine triphosphate	117-121	synemin	Homo sapiens	60-63
19368886-3	2009	We present here three structures of human Poliota in complex with DNAs containing an abasic lesion and dGTP, dTTP, or dATP as the incoming nucleotide.	2'-deoxyadenosine triphosphate	118-122	DNA polymerase mu	Homo sapiens	42-49
19118655-0	2009	Comparative proteomics analysis of caspase-9-protein complexes in untreated and cytochrome c/dATP stimulated lysates of NSCLC cells.	2'-deoxyadenosine triphosphate	93-97	caspase 9	Homo sapiens	35-44
19351147-2	2009	DNA pol beta K(d) values for the alpha,beta-CF(2) and unmodified dNTPs, alpha,beta-NH dUTP, and the alpha,beta-CH(2) analogues of dATP and dGTP are discussed in relation to the conformations of alpha,beta-CF(2) dTTP versus alpha,beta-NH dUTP bound into the enzyme active site.	2'-deoxyadenosine triphosphate	130-134	DNA polymerase beta	Homo sapiens	0-12
19018008-6	2008	Inhibition of adenosine kinase and deoxycytidine kinase prevented the accumulation of dATP and restored thymocyte differentiation and proliferation.	2'-deoxyadenosine triphosphate	86-90	adenosine kinase	Homo sapiens	14-30
19188081-11	2009	Secondarily, a hypothesis is developed for why the V/eta-class might preferentially do cellular dATP insertion opposite [+ta]-B[a]P-N(2)-dG: the small chimney forces adduct-dG lower in the active site, possibly leading to catalysis using a non-canonical dNTP shape that permits syn-adenine:adduct-dG base pairing.	2'-deoxyadenosine triphosphate	96-100	endothelin receptor type A	Homo sapiens	53-56
19220460-6	2009	The k(cat)/K(m) (s(-1) m(-1)) values were 3.11 x 10(4), 4.49 x 10(3) and 1.87 x 10(3) for dCTP, dATP and dTTP, respectively, and RS21-C6 did not hydrolyze dGTP.	2'-deoxyadenosine triphosphate	96-100	dCTP pyrophosphatase 1	Homo sapiens	129-136
18835811-4	2008	The specificity site binds ATP, dATP, dTTP, or dGTP and determines the substrate to be reduced, whereas the overall activity site binds dATP (inhibitor) or ATP.	2'-deoxyadenosine triphosphate	136-140	ttp	Drosophila melanogaster	38-42
19002498-5	2009	It was overexpressed as approximately 50 kDa His-tag fusion protein, and ATP hydrolysis assay of recombinant enzyme showed that either ATP or dATP was required for the unwinding activity, indicating BmL3-helicase as an ATP/dATP-dependent RNA helicase.	2'-deoxyadenosine triphosphate	142-146	DEAD-box helicase 19A	Homo sapiens	238-250
19002498-5	2009	It was overexpressed as approximately 50 kDa His-tag fusion protein, and ATP hydrolysis assay of recombinant enzyme showed that either ATP or dATP was required for the unwinding activity, indicating BmL3-helicase as an ATP/dATP-dependent RNA helicase.	2'-deoxyadenosine triphosphate	223-227	DEAD-box helicase 19A	Homo sapiens	238-250
19333786-2	2008	Activation of caspase-9 is a multi-step process that requires dATP or ATP and involves at least two proteins, cytochrome c and Apaf-1.	2'-deoxyadenosine triphosphate	62-66	caspase 9	Homo sapiens	14-23
19120024-9	2008	dATP was a preferential substrate for synthesis catalyzed by DNA polymerase beta.	2'-deoxyadenosine triphosphate	0-4	DNA polymerase beta	Homo sapiens	61-80
18395187-6	2008	Proteolytic activation of caspases was also affected, as the activation of procaspase-3 and procaspase-9 in HL-60 cell extracts induced by cytochrome c and dATP was inhibited by pre-incubation with GSSG.	2'-deoxyadenosine triphosphate	156-160	caspase 3	Homo sapiens	75-104
18600545-1	2008	Thymocytes lacking adenosine deaminase (ADA) activity, a purine metabolism enzyme, accumulate intracellular dATP and consequently undergo apoptosis during development.	2'-deoxyadenosine triphosphate	108-112	adenosine deaminase	Homo sapiens	19-38
18600545-1	2008	Thymocytes lacking adenosine deaminase (ADA) activity, a purine metabolism enzyme, accumulate intracellular dATP and consequently undergo apoptosis during development.	2'-deoxyadenosine triphosphate	108-112	adenosine deaminase	Homo sapiens	40-43
18600545-2	2008	We have analyzed the effect of ADA enzyme inhibition in human thymocyte suspension cultures with regard to accumulation of intracellular dATP and induction of apoptosis.	2'-deoxyadenosine triphosphate	137-141	adenosine deaminase	Homo sapiens	31-34
18600545-3	2008	We demonstrate that while inhibition of deoxycytidine kinase will prevent the accumulation of dATP and induction of apoptosis to a large degree, inhibition of both deoxycytidine kinase and adenosine kinase completely abrogates the accumulation of dATP and significantly reduces the induction of apoptosis.	2'-deoxyadenosine triphosphate	94-98	deoxycytidine kinase	Homo sapiens	40-60
18600545-3	2008	We demonstrate that while inhibition of deoxycytidine kinase will prevent the accumulation of dATP and induction of apoptosis to a large degree, inhibition of both deoxycytidine kinase and adenosine kinase completely abrogates the accumulation of dATP and significantly reduces the induction of apoptosis.	2'-deoxyadenosine triphosphate	247-251	deoxycytidine kinase	Homo sapiens	164-184
19333786-5	2008	The model predicts that the activation begins with binding of dATP to Apaf-1, which initiates the interaction between Apaf-1 and cytochrome c, thus forming a complex that oligomerizes into an active caspase-9 holoenzyme via a linear binding model with cooperative interaction rather than through network formation.	2'-deoxyadenosine triphosphate	62-66	apoptotic peptidase activating factor 1	Homo sapiens	70-76
19333786-5	2008	The model predicts that the activation begins with binding of dATP to Apaf-1, which initiates the interaction between Apaf-1 and cytochrome c, thus forming a complex that oligomerizes into an active caspase-9 holoenzyme via a linear binding model with cooperative interaction rather than through network formation.	2'-deoxyadenosine triphosphate	62-66	apoptotic peptidase activating factor 1	Homo sapiens	118-124
19333786-5	2008	The model predicts that the activation begins with binding of dATP to Apaf-1, which initiates the interaction between Apaf-1 and cytochrome c, thus forming a complex that oligomerizes into an active caspase-9 holoenzyme via a linear binding model with cooperative interaction rather than through network formation.	2'-deoxyadenosine triphosphate	62-66	cytochrome c, somatic	Homo sapiens	129-141
19333786-5	2008	The model predicts that the activation begins with binding of dATP to Apaf-1, which initiates the interaction between Apaf-1 and cytochrome c, thus forming a complex that oligomerizes into an active caspase-9 holoenzyme via a linear binding model with cooperative interaction rather than through network formation.	2'-deoxyadenosine triphosphate	62-66	caspase 9	Homo sapiens	199-208
18305394-5	2008	The rank order of agonist potency for IL-10 production was 2"-3"-O-(4-benzoyl)-benzoyl ATP (BzATP)=dATP>2-methylthio-ADP (2-meSADP).	2'-deoxyadenosine triphosphate	99-103	interleukin 10	Rattus norvegicus	38-43
18439902-2	2008	The Apaf-1/cytochrome c complex then oligomerizes either into heptameric caspase-9-activating apoptosome, which subsequently activates caspase-3 and caspase-7, or bigger inactive aggregates, depending on the availability of nucleotide dATP/ATP.	2'-deoxyadenosine triphosphate	235-239	apoptotic peptidase activating factor 1	Homo sapiens	4-10
18439902-2	2008	The Apaf-1/cytochrome c complex then oligomerizes either into heptameric caspase-9-activating apoptosome, which subsequently activates caspase-3 and caspase-7, or bigger inactive aggregates, depending on the availability of nucleotide dATP/ATP.	2'-deoxyadenosine triphosphate	235-239	cytochrome c, somatic	Homo sapiens	11-23
18439902-2	2008	The Apaf-1/cytochrome c complex then oligomerizes either into heptameric caspase-9-activating apoptosome, which subsequently activates caspase-3 and caspase-7, or bigger inactive aggregates, depending on the availability of nucleotide dATP/ATP.	2'-deoxyadenosine triphosphate	235-239	caspase 9	Homo sapiens	73-82
18662568-3	2008	The assembly of the mammalian apoptosome, which is responsible for the activation of caspase-9, involves Apaf-1 and requires cytochrome c and ATP/dATP binding.	2'-deoxyadenosine triphosphate	146-150	caspase 9	Homo sapiens	85-94
17483456-0	2007	Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling.	2'-deoxyadenosine triphosphate	26-30	NLR family pyrin domain containing 3	Homo sapiens	0-9
17680812-1	2007	Adenosine deaminase (ADA) deficiency is an inherited disorder which leads to elevated cellular levels of deoxyadenosine triphosphate (dATP) and systemic accumulation of its precursor, 2-deoxyadenosine.	2'-deoxyadenosine triphosphate	105-132	adenosine deaminase	Homo sapiens	0-19
17680812-1	2007	Adenosine deaminase (ADA) deficiency is an inherited disorder which leads to elevated cellular levels of deoxyadenosine triphosphate (dATP) and systemic accumulation of its precursor, 2-deoxyadenosine.	2'-deoxyadenosine triphosphate	105-132	adenosine deaminase	Homo sapiens	21-24
17680812-1	2007	Adenosine deaminase (ADA) deficiency is an inherited disorder which leads to elevated cellular levels of deoxyadenosine triphosphate (dATP) and systemic accumulation of its precursor, 2-deoxyadenosine.	2'-deoxyadenosine triphosphate	134-138	adenosine deaminase	Homo sapiens	0-19
17680812-1	2007	Adenosine deaminase (ADA) deficiency is an inherited disorder which leads to elevated cellular levels of deoxyadenosine triphosphate (dATP) and systemic accumulation of its precursor, 2-deoxyadenosine.	2'-deoxyadenosine triphosphate	134-138	adenosine deaminase	Homo sapiens	21-24
17483456-5	2007	We demonstrate that purified cryopyrin binds ATP, dATP, and ATP-agarose, but not CTP, GTP, or UTP, and exhibits ATPase activity.	2'-deoxyadenosine triphosphate	50-54	NLR family pyrin domain containing 3	Homo sapiens	29-38
17379327-2	2007	Caspase-9 binds to Apaf-1 in the presence of cytochrome c and dATP/ATP, and is activated by self-cleavage.	2'-deoxyadenosine triphosphate	62-66	caspase 9	Homo sapiens	0-9
17379327-2	2007	Caspase-9 binds to Apaf-1 in the presence of cytochrome c and dATP/ATP, and is activated by self-cleavage.	2'-deoxyadenosine triphosphate	62-66	apoptotic peptidase activating factor 1	Homo sapiens	19-25
17483456-0	2007	Cryopyrin/NALP3 binds ATP/dATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling.	2'-deoxyadenosine triphosphate	26-30	NLR family pyrin domain containing 3	Homo sapiens	10-15
17313689-2	2007	To interpret in atomic and energetic detail how pol beta processes 8-oxoG, we apply transition path sampling to delineate closing pathways of pol beta 8-oxoG complexes with dCTP and dATP incoming nucleotides and compare the results to those of the nonlesioned G:dCTP and G:dATPanalogues.	2'-deoxyadenosine triphosphate	182-186	DNA polymerase beta	Homo sapiens	48-56
17293403-0	2007	Differing conformational pathways before and after chemistry for insertion of dATP versus dCTP opposite 8-oxoG in DNA polymerase beta.	2'-deoxyadenosine triphosphate	78-82	DNA polymerase beta	Homo sapiens	114-133
17293403-1	2007	To elucidate how human DNA polymerase beta (pol beta) discriminates dATP from dCTP when processing 8-oxoguanine (8-oxoG), we analyze a series of dynamics simulations before and after the chemical step with dATP and dCTP opposite an 8-oxoG template started from partially open complexes of pol beta.	2'-deoxyadenosine triphosphate	68-72	DNA polymerase beta	Homo sapiens	23-42
17293403-1	2007	To elucidate how human DNA polymerase beta (pol beta) discriminates dATP from dCTP when processing 8-oxoguanine (8-oxoG), we analyze a series of dynamics simulations before and after the chemical step with dATP and dCTP opposite an 8-oxoG template started from partially open complexes of pol beta.	2'-deoxyadenosine triphosphate	68-72	DNA polymerase beta	Homo sapiens	44-52
17293403-1	2007	To elucidate how human DNA polymerase beta (pol beta) discriminates dATP from dCTP when processing 8-oxoguanine (8-oxoG), we analyze a series of dynamics simulations before and after the chemical step with dATP and dCTP opposite an 8-oxoG template started from partially open complexes of pol beta.	2'-deoxyadenosine triphosphate	206-210	DNA polymerase beta	Homo sapiens	23-42
17293403-1	2007	To elucidate how human DNA polymerase beta (pol beta) discriminates dATP from dCTP when processing 8-oxoguanine (8-oxoG), we analyze a series of dynamics simulations before and after the chemical step with dATP and dCTP opposite an 8-oxoG template started from partially open complexes of pol beta.	2'-deoxyadenosine triphosphate	206-210	DNA polymerase beta	Homo sapiens	44-52
17293403-2	2007	Analyses reveal that the thumb closing of pol beta before chemistry is hampered when the incorrect nucleotide dATP is bound opposite 8-oxoG; the unfavorable interaction between active-site residue Tyr(271) and dATP that causes an anti to syn change in the 8-oxoG (syn):dATP complex explains this slow motion, in contrast to the 8-oxoG (anti):dCTP system.	2'-deoxyadenosine triphosphate	110-114	DNA polymerase beta	Homo sapiens	42-50
17293403-2	2007	Analyses reveal that the thumb closing of pol beta before chemistry is hampered when the incorrect nucleotide dATP is bound opposite 8-oxoG; the unfavorable interaction between active-site residue Tyr(271) and dATP that causes an anti to syn change in the 8-oxoG (syn):dATP complex explains this slow motion, in contrast to the 8-oxoG (anti):dCTP system.	2'-deoxyadenosine triphosphate	210-214	DNA polymerase beta	Homo sapiens	42-50
17293403-2	2007	Analyses reveal that the thumb closing of pol beta before chemistry is hampered when the incorrect nucleotide dATP is bound opposite 8-oxoG; the unfavorable interaction between active-site residue Tyr(271) and dATP that causes an anti to syn change in the 8-oxoG (syn):dATP complex explains this slow motion, in contrast to the 8-oxoG (anti):dCTP system.	2'-deoxyadenosine triphosphate	210-214	DNA polymerase beta	Homo sapiens	42-50
17313689-2	2007	To interpret in atomic and energetic detail how pol beta processes 8-oxoG, we apply transition path sampling to delineate closing pathways of pol beta 8-oxoG complexes with dCTP and dATP incoming nucleotides and compare the results to those of the nonlesioned G:dCTP and G:dATPanalogues.	2'-deoxyadenosine triphosphate	182-186	DNA polymerase beta	Homo sapiens	142-150
17313689-7	2007	CONCLUSION: These results suggest that the lower insertion efficiency (larger Km) for dATP compared to dCTP opposite 8-oxoG is caused by a less stable closed-form of pol beta, destabilized by unfavorable interactions between Tyr271 and the mispair.	2'-deoxyadenosine triphosphate	86-90	DNA polymerase beta	Homo sapiens	166-174
16251271-0	2005	Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1.	2'-deoxyadenosine triphosphate	61-65	cytochrome c, somatic	Equus caballus	40-52
16310803-2	2006	To study this process, we assembled a large Dark complex in the presence of dATP.	2'-deoxyadenosine triphosphate	76-80	Death-associated APAF1-related killer	Drosophila melanogaster	44-48
16767158-7	2006	In a cell-free assay, cytochrome c and dATP treatment of cell extracts after immunodepletion of either caspase-3 or caspase-9 indicates that caspase-10 is activated downstream of caspase-9.	2'-deoxyadenosine triphosphate	39-43	caspase 3	Homo sapiens	103-112
16767158-7	2006	In a cell-free assay, cytochrome c and dATP treatment of cell extracts after immunodepletion of either caspase-3 or caspase-9 indicates that caspase-10 is activated downstream of caspase-9.	2'-deoxyadenosine triphosphate	39-43	caspase 9	Homo sapiens	116-125
16767158-7	2006	In a cell-free assay, cytochrome c and dATP treatment of cell extracts after immunodepletion of either caspase-3 or caspase-9 indicates that caspase-10 is activated downstream of caspase-9.	2'-deoxyadenosine triphosphate	39-43	caspase 10	Homo sapiens	141-151
16767158-7	2006	In a cell-free assay, cytochrome c and dATP treatment of cell extracts after immunodepletion of either caspase-3 or caspase-9 indicates that caspase-10 is activated downstream of caspase-9.	2'-deoxyadenosine triphosphate	39-43	caspase 9	Homo sapiens	179-188
17005674-6	2006	Furthermore, Delta97nsP4 is unable to transfer other nucleotides (UTP, CTP, GTP, and dATP) to the acceptor RNA in the absence or presence of other nucleotides.	2'-deoxyadenosine triphosphate	85-89	solute carrier family 10 member 4	Homo sapiens	13-24
16621731-1	2006	In human and rodent cells, MTH1, an oxidized purine nucleoside triphosphatase, efficiently hydrolyzes oxidized dGTP, GTP, dATP and ATP such as 2"-deoxy-8-oxoguanosine triphosphate (8-oxo-dGTP) and 2"-deoxy-2-hydroxyadenosine triphosphate (2-OH-dATP) in nucleotide pools, thus avoiding their incorporation into DNA or RNA.	2'-deoxyadenosine triphosphate	122-126	nudix hydrolase 1	Homo sapiens	27-31
16670300-4	2006	dATP was highly elevated in ADA-deficient cultures, and the recovery of alphabeta TCR(+) thymocytes was inhibited by 94%, indicating that the later stages of thymocyte differentiation are also dependent upon ADA.	2'-deoxyadenosine triphosphate	0-4	adenosine deaminase	Mus musculus	28-31
16670300-4	2006	dATP was highly elevated in ADA-deficient cultures, and the recovery of alphabeta TCR(+) thymocytes was inhibited by 94%, indicating that the later stages of thymocyte differentiation are also dependent upon ADA.	2'-deoxyadenosine triphosphate	0-4	adenosine deaminase	Mus musculus	208-211
16640590-3	2006	We show here that viable parasites prominently inhibited the activation of caspase 3/7 induced by cytochrome c, dATP and dithiothreitol in cytosolic extracts of human-derived Jurkat leukemic T cells.	2'-deoxyadenosine triphosphate	112-116	caspase 3	Homo sapiens	75-84
16376858-9	2006	In allosteric regulation assay, the effect of activation or inhibition of hRRM1 with ATP or dATP suggested that these effectors could regulate RR activity independent of different RR small subunits.	2'-deoxyadenosine triphosphate	92-96	ribonucleotide reductase catalytic subunit M1	Homo sapiens	74-79
16213654-4	2006	The expression of the gene encoding mGluR6 was studied by in situ hybridization in the retina, using an [(35)S]dATP-labeled oligonucleotide probe.	2'-deoxyadenosine triphosphate	111-115	glutamate receptor, ionotropic, kainate 2 (beta 2)	Mus musculus	36-42
16251271-4	2005	Apaf-1 contains a dATP as a cofactor.	2'-deoxyadenosine triphosphate	18-22	apoptotic peptidase activating factor 1	Equus caballus	0-6
16251271-5	2005	Cytochrome c binding to Apaf-1 induces hydrolysis of dATP to dADP, which is subsequently replaced by exogenous dATP.	2'-deoxyadenosine triphosphate	53-57	cytochrome c, somatic	Equus caballus	0-12
16251271-5	2005	Cytochrome c binding to Apaf-1 induces hydrolysis of dATP to dADP, which is subsequently replaced by exogenous dATP.	2'-deoxyadenosine triphosphate	53-57	apoptotic peptidase activating factor 1	Equus caballus	24-30
16251271-5	2005	Cytochrome c binding to Apaf-1 induces hydrolysis of dATP to dADP, which is subsequently replaced by exogenous dATP.	2'-deoxyadenosine triphosphate	111-115	cytochrome c, somatic	Equus caballus	0-12
16251271-5	2005	Cytochrome c binding to Apaf-1 induces hydrolysis of dATP to dADP, which is subsequently replaced by exogenous dATP.	2'-deoxyadenosine triphosphate	111-115	apoptotic peptidase activating factor 1	Equus caballus	24-30
16271896-1	2005	Apaf-1 and cytochrome c coassemble in the presence of dATP to form the apoptosome.	2'-deoxyadenosine triphosphate	54-58	apoptotic peptidase activating factor 1	Homo sapiens	0-6
16285726-6	2005	Analysis of the proton shift of Met282 that results from formation of an abortive Pol beta-gapped DNA-dATP complex is consistent with an open to closed conformational change of the enzyme predicted from crystal structures.	2'-deoxyadenosine triphosphate	102-106	DNA polymerase beta	Homo sapiens	82-90
16271896-1	2005	Apaf-1 and cytochrome c coassemble in the presence of dATP to form the apoptosome.	2'-deoxyadenosine triphosphate	54-58	cytochrome c, somatic	Homo sapiens	11-23
15533835-5	2005	These results suggest that the Orf17 protein may be involved in the hydrolysis of oxidized dATP and dADP.	2'-deoxyadenosine triphosphate	91-95	putative transposase	Escherichia coli	31-36
15882992-6	2005	We find that the NBS domain of CARD12 contains a nucleotide-binding pocket with specificity for ATP/dATP.	2'-deoxyadenosine triphosphate	100-104	NLR family CARD domain containing 4	Homo sapiens	31-37
15848173-7	2005	The cleavage of C3 via calcium-dependent proteolysis is independent of caspase 9; lysate exposure to calcium prevents further cleavage and activation by the cytochrome c and dATP pathway.	2'-deoxyadenosine triphosphate	174-178	caspase 3	Homo sapiens	16-18
15794635-10	2005	Activity assays show that ATP and dATP, but not ADP or AMP, bind to the processed Csp9 p35/p10.	2'-deoxyadenosine triphosphate	34-38	caspase 9	Homo sapiens	82-86
15794635-10	2005	Activity assays show that ATP and dATP, but not ADP or AMP, bind to the processed Csp9 p35/p10.	2'-deoxyadenosine triphosphate	34-38	S100 calcium binding protein A10	Homo sapiens	91-94
15752710-2	2005	Formation of dATP requires phosphorylation of deoxyadenosine by deoxycytidine kinase (dCK), the main nucleoside salvage enzyme in lymphoid cells.	2'-deoxyadenosine triphosphate	13-17	deoxycytidine kinase	Homo sapiens	64-84
15752710-2	2005	Formation of dATP requires phosphorylation of deoxyadenosine by deoxycytidine kinase (dCK), the main nucleoside salvage enzyme in lymphoid cells.	2'-deoxyadenosine triphosphate	13-17	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	86-89
15752710-8	2005	dCK activity was found to be downregulated by growth factor and MAP kinase signalling, providing a potential tool to slow the rate of dATP accumulation in adenosine deaminase deficiency.	2'-deoxyadenosine triphosphate	134-138	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	0-3
16173754-2	2005	We report, using path sampling simulations and a reaction network model, strikingly different transition states in DNA polymerase beta"s conformational closing for correct dCTP versus incorrect dATP incoming nucleotide opposite a template G. The cascade of transition states leads to differing active-site assembly processes toward the "two-metal-ion catalysis" geometry.	2'-deoxyadenosine triphosphate	194-198	DNA polymerase beta	Homo sapiens	115-134
15855170-4	2005	Among nucleotide cofactors, the DNA unwinding by Hmi1p was found to occur efficiently only in the presence of ATP and dATP.	2'-deoxyadenosine triphosphate	118-122	ATP-dependent 3'-5' DNA helicase	Saccharomyces cerevisiae S288C	49-54
15829969-3	2005	During apoptosis, Apaf-1 binds to cytochrome c and in the presence of ATP/dATP forms an apoptosome, leading to the recruitment and activation of the initiator caspase, caspase-9 (ref.	2'-deoxyadenosine triphosphate	74-78	apoptotic peptidase activating factor 1	Homo sapiens	18-24
15829969-3	2005	During apoptosis, Apaf-1 binds to cytochrome c and in the presence of ATP/dATP forms an apoptosome, leading to the recruitment and activation of the initiator caspase, caspase-9 (ref.	2'-deoxyadenosine triphosphate	74-78	caspase 9	Homo sapiens	159-166
15829969-3	2005	During apoptosis, Apaf-1 binds to cytochrome c and in the presence of ATP/dATP forms an apoptosome, leading to the recruitment and activation of the initiator caspase, caspase-9 (ref.	2'-deoxyadenosine triphosphate	74-78	caspase 9	Homo sapiens	168-177
15829969-9	2005	Apaf-1 binds to and hydrolyses ATP/dATP and their analogues.	2'-deoxyadenosine triphosphate	35-39	apoptotic peptidase activating factor 1	Homo sapiens	0-6
15794635-1	2005	ATP or dATP is a required activator of Apaf-1 for formation of the Apoptosome and thereby activation of caspase-9 (Csp9) [Zou, H., Henzel, W. J., Liu, X., Lutschg, A., and Wang, X.	2'-deoxyadenosine triphosphate	7-11	apoptotic peptidase activating factor 1	Homo sapiens	39-45
15794635-1	2005	ATP or dATP is a required activator of Apaf-1 for formation of the Apoptosome and thereby activation of caspase-9 (Csp9) [Zou, H., Henzel, W. J., Liu, X., Lutschg, A., and Wang, X.	2'-deoxyadenosine triphosphate	7-11	caspase 9	Homo sapiens	104-113
15794635-1	2005	ATP or dATP is a required activator of Apaf-1 for formation of the Apoptosome and thereby activation of caspase-9 (Csp9) [Zou, H., Henzel, W. J., Liu, X., Lutschg, A., and Wang, X.	2'-deoxyadenosine triphosphate	7-11	caspase 9	Homo sapiens	115-119
15794635-3	2005	Here we demonstrate that dATP or ATP may have an additional role in controlling Apaf-1-mediated Csp9 activation.	2'-deoxyadenosine triphosphate	25-29	apoptotic peptidase activating factor 1	Homo sapiens	80-86
15794635-3	2005	Here we demonstrate that dATP or ATP may have an additional role in controlling Apaf-1-mediated Csp9 activation.	2'-deoxyadenosine triphosphate	25-29	caspase 9	Homo sapiens	96-100
15794635-4	2005	In the presence of cytochrome c (CytC), dATP or ATP binds to Apaf-1 and triggers heptamerization of Apaf-1 leading to the activation of Csp9.	2'-deoxyadenosine triphosphate	40-44	cytochrome c, somatic	Homo sapiens	19-31
15794635-4	2005	In the presence of cytochrome c (CytC), dATP or ATP binds to Apaf-1 and triggers heptamerization of Apaf-1 leading to the activation of Csp9.	2'-deoxyadenosine triphosphate	40-44	cytochrome c, somatic	Homo sapiens	33-37
15794635-4	2005	In the presence of cytochrome c (CytC), dATP or ATP binds to Apaf-1 and triggers heptamerization of Apaf-1 leading to the activation of Csp9.	2'-deoxyadenosine triphosphate	40-44	apoptotic peptidase activating factor 1	Homo sapiens	61-67
15794635-4	2005	In the presence of cytochrome c (CytC), dATP or ATP binds to Apaf-1 and triggers heptamerization of Apaf-1 leading to the activation of Csp9.	2'-deoxyadenosine triphosphate	40-44	apoptotic peptidase activating factor 1	Homo sapiens	100-106
15794635-4	2005	In the presence of cytochrome c (CytC), dATP or ATP binds to Apaf-1 and triggers heptamerization of Apaf-1 leading to the activation of Csp9.	2'-deoxyadenosine triphosphate	40-44	caspase 9	Homo sapiens	136-140
15794635-5	2005	At concentrations greater than 1 mM, dATP or ATP also functions as a negative regulator of apoptosis by binding to and inhibiting Csp9.	2'-deoxyadenosine triphosphate	37-41	caspase 9	Homo sapiens	130-134
15741329-8	2005	The finding that ATP and dATP are unique among the nucleotides in being able to turn non-native states of cyt c back to native conformation is discussed in the light of cyt c involvement in cell apoptosis.	2'-deoxyadenosine triphosphate	25-29	cytochrome c, somatic	Equus caballus	106-111
15741329-8	2005	The finding that ATP and dATP are unique among the nucleotides in being able to turn non-native states of cyt c back to native conformation is discussed in the light of cyt c involvement in cell apoptosis.	2'-deoxyadenosine triphosphate	25-29	cytochrome c, somatic	Equus caballus	169-174
15779915-1	2005	Recombinant human thymidine kinase 2 (hTK2) expressed in Escherichia coli has been found to bind tightly a substoichiometric amount of deoxyribonucleoside triphosphates (dTTP > dCTP >> dATP), known to be strong feedback inhibitors of the enzyme.	2'-deoxyadenosine triphosphate	194-198	thymidine kinase 2	Homo sapiens	18-36
15779915-1	2005	Recombinant human thymidine kinase 2 (hTK2) expressed in Escherichia coli has been found to bind tightly a substoichiometric amount of deoxyribonucleoside triphosphates (dTTP > dCTP >> dATP), known to be strong feedback inhibitors of the enzyme.	2'-deoxyadenosine triphosphate	194-198	thymidine kinase 2	Homo sapiens	38-42
15220459-3	2004	Characterization of the nsp13-associated nucleoside triphosphatase (NTPase) activities revealed that all natural ribonucleotides and nucleotides are substrates of nsp13, with ATP, dATP, and GTP being hydrolyzed most efficiently.	2'-deoxyadenosine triphosphate	180-184	inosine triphosphatase	Homo sapiens	41-66
15816525-1	2005	A mouse leukemia L1210 cell line (Y8), selected for resistance to deoxyadenosine, has a markedly altered phenotypic expression that includes loss of sensitivity to dATP as an allosteric inhibitor of ribonucleotide reductase, increased expression of c-myc, c-fos and WAF1/p21, but decreased expression of p53.	2'-deoxyadenosine triphosphate	164-168	FBJ osteosarcoma oncogene	Mus musculus	256-261
15816525-1	2005	A mouse leukemia L1210 cell line (Y8), selected for resistance to deoxyadenosine, has a markedly altered phenotypic expression that includes loss of sensitivity to dATP as an allosteric inhibitor of ribonucleotide reductase, increased expression of c-myc, c-fos and WAF1/p21, but decreased expression of p53.	2'-deoxyadenosine triphosphate	164-168	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	266-270
15816525-1	2005	A mouse leukemia L1210 cell line (Y8), selected for resistance to deoxyadenosine, has a markedly altered phenotypic expression that includes loss of sensitivity to dATP as an allosteric inhibitor of ribonucleotide reductase, increased expression of c-myc, c-fos and WAF1/p21, but decreased expression of p53.	2'-deoxyadenosine triphosphate	164-168	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	271-274
15816525-1	2005	A mouse leukemia L1210 cell line (Y8), selected for resistance to deoxyadenosine, has a markedly altered phenotypic expression that includes loss of sensitivity to dATP as an allosteric inhibitor of ribonucleotide reductase, increased expression of c-myc, c-fos and WAF1/p21, but decreased expression of p53.	2'-deoxyadenosine triphosphate	164-168	transformation related protein 53, pseudogene	Mus musculus	304-307
15571254-0	2004	Selective increase of dATP pools upon activation of deoxycytidine kinase in lymphocytes: implications in apoptosis.	2'-deoxyadenosine triphosphate	22-26	deoxycytidine kinase	Homo sapiens	52-72
15571254-2	2004	In light of this, the potential contribution of dCK activation to apoptosis induction--presumably by supplying dATP or its analogues for the apoptosome formation--deserves consideration.	2'-deoxyadenosine triphosphate	111-115	sticky	Drosophila melanogaster	48-51
15571254-6	2004	We assume that dCK activation elicited by cellular damage might be a proapoptotic factor in terms of generating dATP well before the release of cytochrome c and deoxyguanosine kinase from mitochondria.	2'-deoxyadenosine triphosphate	112-116	sticky	Drosophila melanogaster	15-18
15496593-6	2004	Interestingly, this dNTP triphosphohydrolase (dNTPase) activity requires the presence of dATP or dTTP in the dNTP mixture.	2'-deoxyadenosine triphosphate	89-93	NTPase	Drosophila melanogaster	46-53
15220459-3	2004	Characterization of the nsp13-associated nucleoside triphosphatase (NTPase) activities revealed that all natural ribonucleotides and nucleotides are substrates of nsp13, with ATP, dATP, and GTP being hydrolyzed most efficiently.	2'-deoxyadenosine triphosphate	180-184	inosine triphosphatase	Homo sapiens	68-74
14633241-7	2003	The in situ hybridization was carried out on 20 microm cryosections using [35S]dATP-labelled oligonucleotide probe for ENT1 mRNA.	2'-deoxyadenosine triphosphate	79-83	solute carrier family 29 member 1	Rattus norvegicus	119-123
15520873-8	2004	Activation of dCK was paralleled by elevated levels of intracellular dATP, raising the possibility that dCK activation is linked to the induction of apoptosis.	2'-deoxyadenosine triphosphate	69-73	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	14-17
15520873-8	2004	Activation of dCK was paralleled by elevated levels of intracellular dATP, raising the possibility that dCK activation is linked to the induction of apoptosis.	2'-deoxyadenosine triphosphate	69-73	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	104-107
15140959-6	2004	Characterization of the nsp13-associated (deoxy)nucleoside triphosphatase ([dNTPase) activities revealed that all natural nucleotides and deoxynucleotides are substrates of nsp13, with ATP, dATP, and GTP being hydrolyzed slightly more efficiently than other nucleotides.	2'-deoxyadenosine triphosphate	190-194	NTPase	Drosophila melanogaster	76-83
15044458-3	2004	The crystal structure of the MMAB sequence homologue from Thermoplasma acidophilum (TA1434; GenBank identification number gi 16082403) was determined to a resolution of 1.5 A. TA1434 was confirmed to be an ATP:cobalamin adenosyltransferase, which depended absolutely on divalent metal ions (Mg2+ > Mn2+ > Co2+) and only used ATP or dATP as adenosyl donors.	2'-deoxyadenosine triphosphate	338-342	metabolism of cobalamin associated B	Homo sapiens	29-33
15101558-6	2004	By contrast, cytochrome c plus dATP could induce a significant increase of caspase-3-like activity in cytosol only in some NSCLC cell lines and in subsets of studied NSCLC tissues and lungs, while procaspase-3 and -7 were detectably processed only in NSCLC tissues which showed a high (cytochrome c+dATP)-induced caspase-3-like activity.	2'-deoxyadenosine triphosphate	31-35	caspase 3	Homo sapiens	75-84
15101558-6	2004	By contrast, cytochrome c plus dATP could induce a significant increase of caspase-3-like activity in cytosol only in some NSCLC cell lines and in subsets of studied NSCLC tissues and lungs, while procaspase-3 and -7 were detectably processed only in NSCLC tissues which showed a high (cytochrome c+dATP)-induced caspase-3-like activity.	2'-deoxyadenosine triphosphate	31-35	caspase 3	Homo sapiens	197-216
15101558-6	2004	By contrast, cytochrome c plus dATP could induce a significant increase of caspase-3-like activity in cytosol only in some NSCLC cell lines and in subsets of studied NSCLC tissues and lungs, while procaspase-3 and -7 were detectably processed only in NSCLC tissues which showed a high (cytochrome c+dATP)-induced caspase-3-like activity.	2'-deoxyadenosine triphosphate	31-35	cytochrome c, somatic	Homo sapiens	286-298
15101558-6	2004	By contrast, cytochrome c plus dATP could induce a significant increase of caspase-3-like activity in cytosol only in some NSCLC cell lines and in subsets of studied NSCLC tissues and lungs, while procaspase-3 and -7 were detectably processed only in NSCLC tissues which showed a high (cytochrome c+dATP)-induced caspase-3-like activity.	2'-deoxyadenosine triphosphate	31-35	caspase 3	Homo sapiens	200-209
15101558-6	2004	By contrast, cytochrome c plus dATP could induce a significant increase of caspase-3-like activity in cytosol only in some NSCLC cell lines and in subsets of studied NSCLC tissues and lungs, while procaspase-3 and -7 were detectably processed only in NSCLC tissues which showed a high (cytochrome c+dATP)-induced caspase-3-like activity.	2'-deoxyadenosine triphosphate	299-303	cytochrome c, somatic	Homo sapiens	13-25
15101558-6	2004	By contrast, cytochrome c plus dATP could induce a significant increase of caspase-3-like activity in cytosol only in some NSCLC cell lines and in subsets of studied NSCLC tissues and lungs, while procaspase-3 and -7 were detectably processed only in NSCLC tissues which showed a high (cytochrome c+dATP)-induced caspase-3-like activity.	2'-deoxyadenosine triphosphate	299-303	caspase 3	Homo sapiens	75-84
14555239-9	2003	dATP levels were normalized and thymocyte development was rescued in cultures treated with an inhibitor of adenosine kinase, the enzyme that phosphorylates deoxyadenosine to dAMP.	2'-deoxyadenosine triphosphate	0-4	adenosine kinase	Homo sapiens	107-123
14607964-7	2003	A comparison of levels of the ADA substrates, adenosine and 2"-deoxyadenosine, as well resulting dATP levels and S-adenosylhomocysteine hydrolase inhibition in bone marrow and spleen suggested that dATP accumulation in ADA-deficient spleens may be responsible for impaired B cell development.	2'-deoxyadenosine triphosphate	198-202	S-adenosylhomocysteine hydrolase	Mus musculus	113-145
14607964-7	2003	A comparison of levels of the ADA substrates, adenosine and 2"-deoxyadenosine, as well resulting dATP levels and S-adenosylhomocysteine hydrolase inhibition in bone marrow and spleen suggested that dATP accumulation in ADA-deficient spleens may be responsible for impaired B cell development.	2'-deoxyadenosine triphosphate	198-202	adenosine deaminase	Mus musculus	219-222
14555239-11	2003	In contrast, dATP levels remained elevated in ADA-deficient FTOCs with fetal thymuses from Bcl-2 transgenic mice.	2'-deoxyadenosine triphosphate	13-17	B cell leukemia/lymphoma 2	Mus musculus	91-96
12748189-13	2003	The DinG helicase does not discriminate between ribonucleotide and deoxyribonucleotide triphosphates, and it unwinds duplex DNA with similar efficiency in the presence of ATP or dATP.	2'-deoxyadenosine triphosphate	178-182	ring finger protein 2	Homo sapiens	4-8
12927538-4	2003	Moreover, Pol beta can efficiently incorporate rCTP opposite G in the absence of dCTP and, to a lesser extent, rATP opposite T in the absence of dATP and rGTP opposite C in the absence of dGTP.	2'-deoxyadenosine triphosphate	145-149	DNA polymerase beta	Homo sapiens	10-18
12694532-10	2003	dATP, a final metabolite of adenine and 2"-dA, is suggested to inhibit ATR, resulting in PCC.	2'-deoxyadenosine triphosphate	0-4	serine/threonine-protein kinase ATR	Mesocricetus auratus	71-74
12665508-6	2003	We show here that specific expression of GRP78 blocks caspase-7 activation by etoposide both in vivo and in vitro, and this effect can be reversed by addition of dATP in a cell-free system.	2'-deoxyadenosine triphosphate	162-166	heat shock protein family A (Hsp70) member 5	Homo sapiens	41-46
12665508-6	2003	We show here that specific expression of GRP78 blocks caspase-7 activation by etoposide both in vivo and in vitro, and this effect can be reversed by addition of dATP in a cell-free system.	2'-deoxyadenosine triphosphate	162-166	caspase 7	Homo sapiens	54-63
12685655-7	2003	The prevention of proteolysis was also confirmed by both the following results: one is the inhibition of in vitro caspase-3/7 and -9 activation in cell lysates exposed to UVB in the presence of cytochrome c and dATP, which was caused by the production of ROS, and the other is the inhibition of in vitro caspase-3/7 activation in the presence of active caspase-9.	2'-deoxyadenosine triphosphate	211-215	caspase 3	Mus musculus	114-132
12506111-2	2003	Binding of cytochrome c and dATP to Apaf-1 in the cytosol leads to the assembly of a heptameric complex in which each Apaf-1 subunit is bound noncovalently to a procaspase-9 subunit via their respective CARD domains.	2'-deoxyadenosine triphosphate	28-32	apoptotic peptidase activating factor 1	Homo sapiens	36-42
12506111-2	2003	Binding of cytochrome c and dATP to Apaf-1 in the cytosol leads to the assembly of a heptameric complex in which each Apaf-1 subunit is bound noncovalently to a procaspase-9 subunit via their respective CARD domains.	2'-deoxyadenosine triphosphate	28-32	apoptotic peptidase activating factor 1	Homo sapiens	118-124
12685655-7	2003	The prevention of proteolysis was also confirmed by both the following results: one is the inhibition of in vitro caspase-3/7 and -9 activation in cell lysates exposed to UVB in the presence of cytochrome c and dATP, which was caused by the production of ROS, and the other is the inhibition of in vitro caspase-3/7 activation in the presence of active caspase-9.	2'-deoxyadenosine triphosphate	211-215	caspase 3	Mus musculus	114-123
12793746-4	2002	After landing, we labeled space-radiation-induced DNA strand breaks by enzymatic incorporation of [3H]-dATP with terminal deoxyribo-nucleotidyl transferase (TdT).	2'-deoxyadenosine triphosphate	103-107	DNA nucleotidylexotransferase	Homo sapiens	113-155
12644689-5	2003	The At4CL2 mutant M293P/K320L was studied in more detail and was also found to catalyze the synthesis of additional dinucleoside polyphosphates such as diadenosine 5",5"""-P(1),P(5)-pentaphosphate and dAp(4)dA from the appropriate substrates, p(4)A and dATP, respectively.	2'-deoxyadenosine triphosphate	253-257	4-coumarate:CoA ligase 2	Arabidopsis thaliana	4-10
12644689-5	2003	The At4CL2 mutant M293P/K320L was studied in more detail and was also found to catalyze the synthesis of additional dinucleoside polyphosphates such as diadenosine 5",5"""-P(1),P(5)-pentaphosphate and dAp(4)dA from the appropriate substrates, p(4)A and dATP, respectively.	2'-deoxyadenosine triphosphate	253-257	cropped	Drosophila melanogaster	201-209
14708088-7	2003	Conversely, when also an inhibitor of adenosine kinase was added to the incubation mixture, dATP was not formed, and the toxic and apoptotic effect of the combination was completely reverted.	2'-deoxyadenosine triphosphate	92-96	adenosine kinase	Homo sapiens	38-54
12388548-5	2002	pol beta mostly incorporates the correct dATP opposite the 3"-terminus of both CPD and the (6-4) photoproduct but can also misinsert dCTP at a frequency of 32 and 26%, respectively.	2'-deoxyadenosine triphosphate	41-45	DNA polymerase beta	Homo sapiens	0-8
12578384-5	2003	Analysis of the a-site D57N variant of mR1, which differs from wild-type mR1 (wt-mR1) in that its RR activity is activated by both ATP and dATP, demonstrates that dATP activation of the D57N variant RR arises from a blockage in the formation of mR1(4b) from mR1(4a), and provides strong evidence that mR1(4a) forms active complexes with mR2(2).	2'-deoxyadenosine triphosphate	139-143	major histocompatibility complex, class I-related	Mus musculus	39-42
12578384-5	2003	Analysis of the a-site D57N variant of mR1, which differs from wild-type mR1 (wt-mR1) in that its RR activity is activated by both ATP and dATP, demonstrates that dATP activation of the D57N variant RR arises from a blockage in the formation of mR1(4b) from mR1(4a), and provides strong evidence that mR1(4a) forms active complexes with mR2(2).	2'-deoxyadenosine triphosphate	163-167	major histocompatibility complex, class I-related	Mus musculus	39-42
12578384-5	2003	Analysis of the a-site D57N variant of mR1, which differs from wild-type mR1 (wt-mR1) in that its RR activity is activated by both ATP and dATP, demonstrates that dATP activation of the D57N variant RR arises from a blockage in the formation of mR1(4b) from mR1(4a), and provides strong evidence that mR1(4a) forms active complexes with mR2(2).	2'-deoxyadenosine triphosphate	163-167	ribonucleotide reductase M2	Mus musculus	337-340
12578384-6	2003	We further demonstrate that (a) differences in the effects of ATP versus dATP binding to the a-site of wt-mR1 provide specific mechanisms by which the dATP/ATP ratio in mammalian cells could modulate in vivo RR enzymatic activity, (b) the comprehensive model is valid over a range of Mg(2+) concentrations that include in vivo concentrations, and (c) equilibrium constants derived for the comprehensive model can be used to simulate the distribution of R1 among dimer, tetramer, and hexamer forms in vivo.	2'-deoxyadenosine triphosphate	73-77	major histocompatibility complex, class I-related	Mus musculus	106-109
12578384-6	2003	We further demonstrate that (a) differences in the effects of ATP versus dATP binding to the a-site of wt-mR1 provide specific mechanisms by which the dATP/ATP ratio in mammalian cells could modulate in vivo RR enzymatic activity, (b) the comprehensive model is valid over a range of Mg(2+) concentrations that include in vivo concentrations, and (c) equilibrium constants derived for the comprehensive model can be used to simulate the distribution of R1 among dimer, tetramer, and hexamer forms in vivo.	2'-deoxyadenosine triphosphate	73-77	major histocompatibility complex, class I-related	Mus musculus	107-109
12578384-6	2003	We further demonstrate that (a) differences in the effects of ATP versus dATP binding to the a-site of wt-mR1 provide specific mechanisms by which the dATP/ATP ratio in mammalian cells could modulate in vivo RR enzymatic activity, (b) the comprehensive model is valid over a range of Mg(2+) concentrations that include in vivo concentrations, and (c) equilibrium constants derived for the comprehensive model can be used to simulate the distribution of R1 among dimer, tetramer, and hexamer forms in vivo.	2'-deoxyadenosine triphosphate	151-155	major histocompatibility complex, class I-related	Mus musculus	106-109
12578384-6	2003	We further demonstrate that (a) differences in the effects of ATP versus dATP binding to the a-site of wt-mR1 provide specific mechanisms by which the dATP/ATP ratio in mammalian cells could modulate in vivo RR enzymatic activity, (b) the comprehensive model is valid over a range of Mg(2+) concentrations that include in vivo concentrations, and (c) equilibrium constants derived for the comprehensive model can be used to simulate the distribution of R1 among dimer, tetramer, and hexamer forms in vivo.	2'-deoxyadenosine triphosphate	151-155	major histocompatibility complex, class I-related	Mus musculus	107-109
12439591-6	2002	The caspase cascade is activated by the release of cytochrome c, which is initiated by the formation of apoptosomes consisting of procaspase-9, Apaf-1 and cytochrome c in the presence of dATP, and results in the activation of caspase-9 and caspase-3, thereby leading to apoptosis.	2'-deoxyadenosine triphosphate	187-191	cytochrome c, somatic	Homo sapiens	51-63
12439591-6	2002	The caspase cascade is activated by the release of cytochrome c, which is initiated by the formation of apoptosomes consisting of procaspase-9, Apaf-1 and cytochrome c in the presence of dATP, and results in the activation of caspase-9 and caspase-3, thereby leading to apoptosis.	2'-deoxyadenosine triphosphate	187-191	caspase 3	Homo sapiens	240-249
11926999-2	2002	Our recent studies demonstrated that rat GlcNAc 2-epimerase has a ten-times higher affinity for ATP, dATP, and ddATP than the human enzyme [Takahashi, S. et al.	2'-deoxyadenosine triphosphate	101-105	renin binding protein	Rattus norvegicus	41-59
12171961-6	2002	METHODS: Mucin mRNA was detected by in situ hybridisation using [(35)S]dATP labelled oligonucleotide probes.	2'-deoxyadenosine triphosphate	71-75	LOC100508689	Homo sapiens	9-14
12181327-4	2002	Purified recombinant HDHB hydrolyzed ATP and dATP in the presence of single-stranded DNA, displayed robust 5"-3" DNA helicase activity, and interacted physically and functionally with DNA polymerase alpha-primase.	2'-deoxyadenosine triphosphate	45-49	DNA helicase B	Homo sapiens	21-25
12163459-0	2002	Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulation.	2'-deoxyadenosine triphosphate	108-112	adenosine kinase	Mus musculus	0-16
12163459-0	2002	Adenosine kinase inhibition promotes survival of fetal adenosine deaminase-deficient thymocytes by blocking dATP accumulation.	2'-deoxyadenosine triphosphate	108-112	adenosine deaminase	Mus musculus	55-74
12163459-6	2002	In ADA-inhibited FTOCs rescued with a Bcl-2 transgene, however, dATP levels were superelevated, suggesting that cells failing positive and negative selection continued to contribute to the accumulation of ADA substrates.	2'-deoxyadenosine triphosphate	64-68	B cell leukemia/lymphoma 2	Mus musculus	38-43
12215208-8	2002	dATP/ATP and reducing factors including Trx determine the manifestation of cell death, apoptosis or necrosis, by regulating the activation process and the activity of redox-sensitive caspases.	2'-deoxyadenosine triphosphate	0-4	thioredoxin	Homo sapiens	40-43
11903057-7	2002	With respect to NTPase activity, eIF4A hydrolysed only ATP or dATP in the presence of RNAs, whereas HCV NS3 helicase could hydrolyse all ribo- and deoxyribo-NTPs in an RNA-independent manner.	2'-deoxyadenosine triphosphate	62-66	eukaryotic translation initiation factor 4A1	Homo sapiens	33-38
11903057-8	2002	In parallel, only ATP or dATP could drive the unwinding activity of eIF4A whereas HCV NS3 could function with all eight standard NTPs and dNTPs.	2'-deoxyadenosine triphosphate	25-29	eukaryotic translation initiation factor 4A1	Homo sapiens	68-73
11821144-0	2002	Kinetic analysis of [35S]dATP alpha S interaction with P2y(1) nucleotide receptor.	2'-deoxyadenosine triphosphate	25-29	purinergic receptor P2Y1	Homo sapiens	55-61
11415444-7	2001	In control dATP-activated lysates, Apaf-1 oligomerized to a biologically active caspase processing approximately 700 kDa complex and an inactive approximately 1.4 MDa complex.	2'-deoxyadenosine triphosphate	11-15	apoptotic peptidase activating factor 1	Homo sapiens	35-41
11912132-8	2002	UMP/CMPK used all of the nucleoside triphosphates as phosphate donors, with ATP and dATP being the best donors and CTP being the poorest.	2'-deoxyadenosine triphosphate	84-88	cytidine/uridine monophosphate kinase 1	Homo sapiens	0-3
11912132-8	2002	UMP/CMPK used all of the nucleoside triphosphates as phosphate donors, with ATP and dATP being the best donors and CTP being the poorest.	2'-deoxyadenosine triphosphate	84-88	cytidine/uridine monophosphate kinase 1	Homo sapiens	4-8
11781084-4	2002	In this model, nucleotide binding to the specificity site (s-site) drives formation of an active R1(2)R2(2) dimer, ATP or dATP binding to the adenine-specific site (a-site) results in formation of an inactive tetramer, and ATP binding to the newly described hexamerization site (h-site) drives formation of active R1(6)R2(6) hexamer.	2'-deoxyadenosine triphosphate	122-126	major histocompatibility complex, class I-related	Mus musculus	97-99
11781084-4	2002	In this model, nucleotide binding to the specificity site (s-site) drives formation of an active R1(2)R2(2) dimer, ATP or dATP binding to the adenine-specific site (a-site) results in formation of an inactive tetramer, and ATP binding to the newly described hexamerization site (h-site) drives formation of active R1(6)R2(6) hexamer.	2'-deoxyadenosine triphosphate	122-126	ribonucleotide reductase M2	Mus musculus	102-104
11781084-4	2002	In this model, nucleotide binding to the specificity site (s-site) drives formation of an active R1(2)R2(2) dimer, ATP or dATP binding to the adenine-specific site (a-site) results in formation of an inactive tetramer, and ATP binding to the newly described hexamerization site (h-site) drives formation of active R1(6)R2(6) hexamer.	2'-deoxyadenosine triphosphate	122-126	major histocompatibility complex, class I-related	Mus musculus	314-316
11781084-4	2002	In this model, nucleotide binding to the specificity site (s-site) drives formation of an active R1(2)R2(2) dimer, ATP or dATP binding to the adenine-specific site (a-site) results in formation of an inactive tetramer, and ATP binding to the newly described hexamerization site (h-site) drives formation of active R1(6)R2(6) hexamer.	2'-deoxyadenosine triphosphate	122-126	ribonucleotide reductase M2	Mus musculus	319-321
12182888-6	2002	Immunoreactivity to P2Y(1) receptor (P2Y(1)-IR) exhibited similar distribution patterns to [alpha(33)P]dATP binding, with a clear topographic profile.	2'-deoxyadenosine triphosphate	103-107	purinergic receptor P2Y1	Rattus norvegicus	20-26
11785937-8	2001	Either ATP or dATP is required for the unwinding activity, indicating that VrRHI is an ATP/dATP-dependent RNA helicase.	2'-deoxyadenosine triphosphate	91-95	DEAD-box ATP-dependent RNA helicase 7	Vigna radiata	106-118
11720284-6	2001	We also show that, unlike the human tri-snRNP, the yeast tri-snRNP dissociated upon addition of ATP or dATP.	2'-deoxyadenosine triphosphate	103-107	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	61-66
11553774-5	2001	JFC1, which also hydrolyzed dATP, has a relatively high affinity for ATP, with a K(M) value of 58 microM, and a k(cat) value of 2.27 per min.	2'-deoxyadenosine triphosphate	28-32	synaptotagmin like 1	Homo sapiens	0-4
11516099-6	2001	Activation of B-CLL lysates with dATP results in the formation of an approximately 700 kDa caspase-activating apoptosome complex containing Apaf-1.	2'-deoxyadenosine triphosphate	33-37	apoptotic peptidase activating factor 1	Homo sapiens	140-146
11901173-6	2002	In vitro, DRONC was recruited to a >700-kD complex, similar to the mammalian apoptosome in cell extracts supplemented with cytochrome c and dATP.	2'-deoxyadenosine triphosphate	143-147	Death regulator Nedd2-like caspase	Drosophila melanogaster	10-15
11872716-7	2002	As is the case with the E. coli RecA protein, the use of dATP as a cofactor permits more facile displacement of bound SSB protein from ssDNA.	2'-deoxyadenosine triphosphate	57-61	single-stranded DNA-binding protein	Escherichia coli	118-121
11779177-7	2002	Unlike its mammalian homologue Apaf-1, CED-4 exhibited a marked preference for ATP over dATP in filter binding studies and in competition experiments.	2'-deoxyadenosine triphosphate	88-92	apoptotic peptidase activating factor 1	Homo sapiens	39-44
11726282-8	2001	The human GlcNAc 2-epimerase activity could not be detected in the absence of a nucleotide, whereas ATP, dATP, ddATP, ADP, and GTP enhanced the human GlcNAc 2-epimerase activity.	2'-deoxyadenosine triphosphate	105-109	renin binding protein	Homo sapiens	150-168
11697897-8	2001	Comparison of the steady-state kinetic parameters for both reactions, suggested that dATP, l-(beta)-dCTP and l-(beta)-dTTP, specifically reduced a rate limiting step present in the helicase, but not in the NTPase, reaction pathway.	2'-deoxyadenosine triphosphate	85-89	helicase for meiosis 1	Homo sapiens	181-189
11697897-8	2001	Comparison of the steady-state kinetic parameters for both reactions, suggested that dATP, l-(beta)-dCTP and l-(beta)-dTTP, specifically reduced a rate limiting step present in the helicase, but not in the NTPase, reaction pathway.	2'-deoxyadenosine triphosphate	85-89	inosine triphosphatase	Homo sapiens	206-212
11520805-2	2001	Once released, cytochrome c cooperates with apoptotic protease-activating factor-1 and deoxyadenosine triphosphate in caspase-9 activation and initiation of the apoptotic protease cascade.	2'-deoxyadenosine triphosphate	87-114	cytochrome c, somatic	Homo sapiens	15-27
11520805-2	2001	Once released, cytochrome c cooperates with apoptotic protease-activating factor-1 and deoxyadenosine triphosphate in caspase-9 activation and initiation of the apoptotic protease cascade.	2'-deoxyadenosine triphosphate	87-114	caspase 9	Homo sapiens	118-127
11697650-3	2001	dATP effectively induces caspase-3 activation in cytosol from monocytoid cells, but not in that from non-monocytoid cells, suggesting that dATP-dependent caspase-3 activation is involved in the preferential induction of apoptosis in monocytoid leukemia cells.	2'-deoxyadenosine triphosphate	0-4	caspase 3	Homo sapiens	25-34
11697650-3	2001	dATP effectively induces caspase-3 activation in cytosol from monocytoid cells, but not in that from non-monocytoid cells, suggesting that dATP-dependent caspase-3 activation is involved in the preferential induction of apoptosis in monocytoid leukemia cells.	2'-deoxyadenosine triphosphate	0-4	caspase 3	Homo sapiens	154-163
11697650-3	2001	dATP effectively induces caspase-3 activation in cytosol from monocytoid cells, but not in that from non-monocytoid cells, suggesting that dATP-dependent caspase-3 activation is involved in the preferential induction of apoptosis in monocytoid leukemia cells.	2'-deoxyadenosine triphosphate	139-143	caspase 3	Homo sapiens	25-34
11697650-3	2001	dATP effectively induces caspase-3 activation in cytosol from monocytoid cells, but not in that from non-monocytoid cells, suggesting that dATP-dependent caspase-3 activation is involved in the preferential induction of apoptosis in monocytoid leukemia cells.	2'-deoxyadenosine triphosphate	139-143	caspase 3	Homo sapiens	154-163
11489842-9	2001	These results demonstrate that a wild-type p53 cell line can be radiosensitized by dFdCyd, presumably because it was able to deplete dATP levels and progress through the cell cycle for at least 24 h after drug and radiation treatment.	2'-deoxyadenosine triphosphate	133-137	tumor protein p53	Homo sapiens	43-46
11425472-3	2001	UTR1p specifically phosphorylated NAD in the presence of ATP, dATP, or CTP as phosphoryl donors, and was most active at pH 8.0, 30 degrees C. Km values of UTR1p for NAD and ATP were determined to be 0.50 mM and 0.60 mM, respectively.	2'-deoxyadenosine triphosphate	62-66	NADH/NAD(+) kinase	Saccharomyces cerevisiae S288C	0-5
11294860-6	2001	The redistribution of dGK from the mitochondria to the cytosol may be of importance for the activation of apoptotic purine nucleoside cofactors such as dATP and demonstrates that mitochondrial matrix proteins may selectively leak out during apoptosis.	2'-deoxyadenosine triphosphate	152-156	Diacyl glycerol kinase	Drosophila melanogaster	22-25
11425472-3	2001	UTR1p specifically phosphorylated NAD in the presence of ATP, dATP, or CTP as phosphoryl donors, and was most active at pH 8.0, 30 degrees C. Km values of UTR1p for NAD and ATP were determined to be 0.50 mM and 0.60 mM, respectively.	2'-deoxyadenosine triphosphate	62-66	NADH/NAD(+) kinase	Saccharomyces cerevisiae S288C	155-160
11264002-1	2001	Apaf-1 plays a crucial role in the cytochrome c/dATP-dependent activation of caspase-9 and -3.	2'-deoxyadenosine triphosphate	48-52	apoptotic peptidase activating factor 1	Homo sapiens	0-6
11376687-9	2001	MTH1 but not MutT efficiently hydrolyzes two forms of oxidized dATP, 2-hydroxy-dATP and 8-oxo-dATP, as well as 8-oxo-dGTP and 8-oxo-GTP.	2'-deoxyadenosine triphosphate	63-67	nudix hydrolase 1	Homo sapiens	0-4
11550094-1	2001	Cytochrome c and dATP/ATP induce oligomerization of Apaf-1 into two distinct apoptosome complexes: an approximately 700 kDa complex, which recruits and activates caspases-9, -3 and -7, and an approximately 1.4 MDa complex, which recruits and processes caspase-9, but does not efficiently activate effector caspases.	2'-deoxyadenosine triphosphate	17-21	apoptotic peptidase activating factor 1	Homo sapiens	52-58
11550094-1	2001	Cytochrome c and dATP/ATP induce oligomerization of Apaf-1 into two distinct apoptosome complexes: an approximately 700 kDa complex, which recruits and activates caspases-9, -3 and -7, and an approximately 1.4 MDa complex, which recruits and processes caspase-9, but does not efficiently activate effector caspases.	2'-deoxyadenosine triphosphate	17-21	caspase 9	Homo sapiens	162-183
11550094-1	2001	Cytochrome c and dATP/ATP induce oligomerization of Apaf-1 into two distinct apoptosome complexes: an approximately 700 kDa complex, which recruits and activates caspases-9, -3 and -7, and an approximately 1.4 MDa complex, which recruits and processes caspase-9, but does not efficiently activate effector caspases.	2'-deoxyadenosine triphosphate	17-21	caspase 9	Homo sapiens	252-261
11550094-1	2001	Cytochrome c and dATP/ATP induce oligomerization of Apaf-1 into two distinct apoptosome complexes: an approximately 700 kDa complex, which recruits and activates caspases-9, -3 and -7, and an approximately 1.4 MDa complex, which recruits and processes caspase-9, but does not efficiently activate effector caspases.	2'-deoxyadenosine triphosphate	17-21	caspase 9	Homo sapiens	162-170
11550094-3	2001	We subsequently determined that caspase-3 cleaved Apaf-1 within its CED-4 domain (SVTD(271) downward arrowS) in both dATP-activated lysates and apoptotic cells to form a prominent approximately 30 kDa (p30) N-terminal fragment.	2'-deoxyadenosine triphosphate	117-121	caspase 3	Homo sapiens	32-41
11550094-3	2001	We subsequently determined that caspase-3 cleaved Apaf-1 within its CED-4 domain (SVTD(271) downward arrowS) in both dATP-activated lysates and apoptotic cells to form a prominent approximately 30 kDa (p30) N-terminal fragment.	2'-deoxyadenosine triphosphate	117-121	apoptotic peptidase activating factor 1	Homo sapiens	50-56
11550094-4	2001	Purified recombinant Apaf-1 p30 fragment weakly inhibited dATP-dependent activation of caspase-3 in vitro.	2'-deoxyadenosine triphosphate	58-62	apoptotic peptidase activating factor 1	Homo sapiens	21-27
11550094-4	2001	Purified recombinant Apaf-1 p30 fragment weakly inhibited dATP-dependent activation of caspase-3 in vitro.	2'-deoxyadenosine triphosphate	58-62	caspase 3	Homo sapiens	87-96
11264002-1	2001	Apaf-1 plays a crucial role in the cytochrome c/dATP-dependent activation of caspase-9 and -3.	2'-deoxyadenosine triphosphate	48-52	cytochrome c, somatic	Homo sapiens	35-47
11264002-1	2001	Apaf-1 plays a crucial role in the cytochrome c/dATP-dependent activation of caspase-9 and -3.	2'-deoxyadenosine triphosphate	48-52	caspase 9	Homo sapiens	77-93
11230124-1	2001	During apoptosis, release of cytochrome c initiates dATP-dependent oligomerization of Apaf-1 and formation of the apoptosome.	2'-deoxyadenosine triphosphate	52-56	cytochrome c, somatic	Homo sapiens	29-41
11230124-1	2001	During apoptosis, release of cytochrome c initiates dATP-dependent oligomerization of Apaf-1 and formation of the apoptosome.	2'-deoxyadenosine triphosphate	52-56	apoptotic peptidase activating factor 1	Homo sapiens	86-92
11230124-4	2001	We demonstrate that XIAP, an inhibitor-of-apoptosis protein, is normally present in high molecular weight complexes in unactivated cell lysates, but directly interacts with the apoptosome in cytochrome c/dATP-activated lysates.	2'-deoxyadenosine triphosphate	204-208	X-linked inhibitor of apoptosis	Homo sapiens	20-24
11501068-5	2000	DNA fragments of about 1.0 kb in length were obtained by RT-PCR from RNA isolated from these cells and were detected by FUT2-specific [alpha-32P]dATP labeled DNA probes.	2'-deoxyadenosine triphosphate	145-149	fucosyltransferase 2	Homo sapiens	120-124
11076872-5	2000	METHODS: Mucin mRNA was detected by in situ hybridisation using [(35)S] dATP labelled oligonucleotide probes.	2'-deoxyadenosine triphosphate	72-76	LOC100508689	Homo sapiens	9-14
11071652-2	2000	To explain why deoxyadenosine and its analogs are toxic to a cell that is not undergoing replicative DNA synthesis, several mechanisms have been proposed, including the direct binding of dATP to the pro-apoptotic factor Apaf-1 and the activation of the caspase-9 and -3 pathways.	2'-deoxyadenosine triphosphate	187-191	apoptotic peptidase activating factor 1	Homo sapiens	220-226
11071652-2	2000	To explain why deoxyadenosine and its analogs are toxic to a cell that is not undergoing replicative DNA synthesis, several mechanisms have been proposed, including the direct binding of dATP to the pro-apoptotic factor Apaf-1 and the activation of the caspase-9 and -3 pathways.	2'-deoxyadenosine triphosphate	187-191	caspase 9	Homo sapiens	253-269
11392817-4	2001	The low size DNA fragments (0.2, 0.4 and 11.0 kb) were observed only following stress (a 5 min swimming in water bath) by means of alpha-32P-dATP incorporation mediated by TdT reaction.	2'-deoxyadenosine triphosphate	141-145	deoxynucleotidyltransferase, terminal	Mus musculus	172-175
11035811-0	2000	Cytochrome c binding to Apaf-1: the effects of dATP and ionic strength.	2'-deoxyadenosine triphosphate	47-51	cytochrome c, somatic	Homo sapiens	0-12
11067867-2	2000	C57BL/6 fetal thymuses treated with the specific ADA inhibitor 2"-deoxycoformycin exhibited features of the human disease, including accumulation of dATP and inhibition of S-adenosylhomocysteine hydrolase enzyme activity.	2'-deoxyadenosine triphosphate	149-153	adenosine deaminase	Homo sapiens	49-52
11035811-0	2000	Cytochrome c binding to Apaf-1: the effects of dATP and ionic strength.	2'-deoxyadenosine triphosphate	47-51	apoptotic peptidase activating factor 1	Homo sapiens	24-30
11035811-3	2000	Here, we show through fluorescence polarization experiments that cytochrome c can bind to Apaf-1 in the absence of dATP; when dATP is added to the cytochrome c.Apaf-1 complex, further assembly occurs to produce the apoptosome.	2'-deoxyadenosine triphosphate	115-119	cytochrome c, somatic	Homo sapiens	65-77
11035811-3	2000	Here, we show through fluorescence polarization experiments that cytochrome c can bind to Apaf-1 in the absence of dATP; when dATP is added to the cytochrome c.Apaf-1 complex, further assembly occurs to produce the apoptosome.	2'-deoxyadenosine triphosphate	126-130	cytochrome c, somatic	Homo sapiens	65-77
11035811-3	2000	Here, we show through fluorescence polarization experiments that cytochrome c can bind to Apaf-1 in the absence of dATP; when dATP is added to the cytochrome c.Apaf-1 complex, further assembly occurs to produce the apoptosome.	2'-deoxyadenosine triphosphate	126-130	apoptotic peptidase activating factor 1	Homo sapiens	90-96
11035811-3	2000	Here, we show through fluorescence polarization experiments that cytochrome c can bind to Apaf-1 in the absence of dATP; when dATP is added to the cytochrome c.Apaf-1 complex, further assembly occurs to produce the apoptosome.	2'-deoxyadenosine triphosphate	126-130	cytochrome c, somatic	Homo sapiens	147-159
10940292-2	2000	Using a nucleotide binding assay, we found that Apaf-1 alone bound dATP poorly and the nucleotide binding to Apaf-1 was significantly stimulated by cytochrome c.	2'-deoxyadenosine triphosphate	67-71	apoptotic peptidase activating factor 1	Homo sapiens	48-54
11035811-3	2000	Here, we show through fluorescence polarization experiments that cytochrome c can bind to Apaf-1 in the absence of dATP; when dATP is added to the cytochrome c.Apaf-1 complex, further assembly occurs to produce the apoptosome.	2'-deoxyadenosine triphosphate	126-130	apoptotic peptidase activating factor 1	Homo sapiens	160-166
10940292-8	2000	These data indicate that the key event in Apaf-1-mediated caspase-9 activation is cytochrome c-induced dATP binding to Apaf-1.	2'-deoxyadenosine triphosphate	103-107	caspase 9	Homo sapiens	58-67
10940292-8	2000	These data indicate that the key event in Apaf-1-mediated caspase-9 activation is cytochrome c-induced dATP binding to Apaf-1.	2'-deoxyadenosine triphosphate	103-107	cytochrome c, somatic	Homo sapiens	82-94
10940292-3	2000	The binding of dATP to Apaf-1 induces the formation of a multimeric Apaf-1.	2'-deoxyadenosine triphosphate	15-19	apoptotic peptidase activating factor 1	Homo sapiens	23-29
10940292-8	2000	These data indicate that the key event in Apaf-1-mediated caspase-9 activation is cytochrome c-induced dATP binding to Apaf-1.	2'-deoxyadenosine triphosphate	103-107	apoptotic peptidase activating factor 1	Homo sapiens	119-125
10940292-3	2000	The binding of dATP to Apaf-1 induces the formation of a multimeric Apaf-1.	2'-deoxyadenosine triphosphate	15-19	apoptotic peptidase activating factor 1	Homo sapiens	68-74
10940292-5	2000	Procaspase-9 also synergistically promotes dATP binding to Apaf-1 in a cytochrome c-dependent manner.	2'-deoxyadenosine triphosphate	43-47	apoptotic peptidase activating factor 1	Homo sapiens	59-65
10940292-5	2000	Procaspase-9 also synergistically promotes dATP binding to Apaf-1 in a cytochrome c-dependent manner.	2'-deoxyadenosine triphosphate	43-47	cytochrome c, somatic	Homo sapiens	71-83
10940292-8	2000	These data indicate that the key event in Apaf-1-mediated caspase-9 activation is cytochrome c-induced dATP binding to Apaf-1.	2'-deoxyadenosine triphosphate	103-107	apoptotic peptidase activating factor 1	Homo sapiens	42-48
11015299-2	2000	Treatment with the potent P2Y(11) receptor activator dATP evoked an elevated intracellular Ca(2+) concentration ([Ca(2+)](i)) and inositol 1,4,5-trisphosphate (IP(3)) production that was sustained for longer than 30 min.	2'-deoxyadenosine triphosphate	53-57	purinergic receptor P2Y11	Homo sapiens	26-33
10806214-5	2000	Caspase-3 cleavage and DNA fragmentation were detected in cytosolic fractions from normal cells upon addition of dATP, but not from preheated U937 or U937/hsp70 cells.	2'-deoxyadenosine triphosphate	113-117	caspase 3	Homo sapiens	0-9
11003619-5	2000	Similarly, in vitro activation of hepatoma cell lysates with 2"-deoxyadenosine 5"-triphosphate (dATP) results in the formation of the approximately 700-kd apoptosome complex, which recruits and processes caspases-3 and -7.	2'-deoxyadenosine triphosphate	61-94	caspase 3	Rattus norvegicus	204-221
11003619-5	2000	Similarly, in vitro activation of hepatoma cell lysates with 2"-deoxyadenosine 5"-triphosphate (dATP) results in the formation of the approximately 700-kd apoptosome complex, which recruits and processes caspases-3 and -7.	2'-deoxyadenosine triphosphate	96-100	caspase 3	Rattus norvegicus	204-221
11003619-6	2000	Z-VAD.FMK [benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone], the pan-caspase inhibitor totally inhibits dATP-stimulated caspase activation but does not block the assembly of the large Apaf-1 containing apoptosome complex.	2'-deoxyadenosine triphosphate	111-115	apoptotic peptidase activating factor 1	Rattus norvegicus	191-197
11036238-1	2000	The distribution and cellular localization of dopamine D1A and D1B receptor mRNAs in the forebrain and midbrain of the domestic chick were examined using in situ hybridization histochemistry with 35[S]-dATP labeled oligonucleotide probes, visualized with film and emulsion autoradiography.	2'-deoxyadenosine triphosphate	202-206	dopamine receptor D5	Gallus gallus	46-75
11185963-4	2000	Activated caspase-8 is known to propagate the apoptotic signal either by directly cleaving and activating downstream caspases or by cleaving the BH3 Bcl2-interacting protein, which leads to the release of cytochrome c from mitochondria, triggering activation of caspase-9 in a complex with dATP and Apaf-1.	2'-deoxyadenosine triphosphate	290-294	caspase 8	Mus musculus	10-19
10816561-9	2000	In [(3)H]NECA displacement assays, GRP94 displayed binding interactions with ATP, dATP, ADP, AMP, cAMP, and adenosine, but not GTP, CTP, or UTP.	2'-deoxyadenosine triphosphate	82-86	heat shock protein 90 beta family member 1	Homo sapiens	35-40
10934467-1	2000	Release of cytochrome c from mitochondria by apoptotic signals induces ATP/dATP-dependent formation of the oligomeric Apaf-1-caspase-9 apoptosome.	2'-deoxyadenosine triphosphate	75-79	cytochrome c, somatic	Homo sapiens	11-23
10934467-1	2000	Release of cytochrome c from mitochondria by apoptotic signals induces ATP/dATP-dependent formation of the oligomeric Apaf-1-caspase-9 apoptosome.	2'-deoxyadenosine triphosphate	75-79	apoptotic peptidase activating factor 1	Homo sapiens	118-124
10769169-13	2000	c/dATP stimulated caspase-9 processing and downstreamcaspase activation were significantly suppressed in the presence ofTPCK and APF.	2'-deoxyadenosine triphosphate	2-6	caspase 9	Rattus norvegicus	18-27
10862031-8	2000	This and 2 other cell lines carrying APAF1 deletions also exhibited defects in dATP-mediated caspase-3 activation.	2'-deoxyadenosine triphosphate	79-83	apoptotic peptidase activating factor 1	Homo sapiens	37-42
10862031-8	2000	This and 2 other cell lines carrying APAF1 deletions also exhibited defects in dATP-mediated caspase-3 activation.	2'-deoxyadenosine triphosphate	79-83	caspase 3	Homo sapiens	93-102
10653647-3	2000	For wild-type pol beta, there is a 2:1 preference for incorporation of dCTP over dATP opposite 8-oxodG using a 5"-phosphorylated 4-base gap substrate.	2'-deoxyadenosine triphosphate	81-85	DNA polymerase beta	Homo sapiens	14-22
10766770-5	2000	Here we report that dATP hydrolysis by An3 is stimulated approximately 6-fold by total RNA from X. laevis oocytes, whereas poly(U) RNA fails to enhance hydrolysis, suggesting the existence of a specific RNA activator for An3.	2'-deoxyadenosine triphosphate	20-24	DEAD-box helicase 3 X-linked S homeolog	Xenopus laevis	39-42
10766770-5	2000	Here we report that dATP hydrolysis by An3 is stimulated approximately 6-fold by total RNA from X. laevis oocytes, whereas poly(U) RNA fails to enhance hydrolysis, suggesting the existence of a specific RNA activator for An3.	2'-deoxyadenosine triphosphate	20-24	DEAD-box helicase 3 X-linked S homeolog	Xenopus laevis	221-224
10722681-2	2000	Apaf-1 is an important apoptotic signaling molecule that can activate procaspase-9 in a cytochrome c/dATP-dependent fashion.	2'-deoxyadenosine triphosphate	101-105	apoptotic peptidase activating factor 1	Homo sapiens	0-6
10722681-2	2000	Apaf-1 is an important apoptotic signaling molecule that can activate procaspase-9 in a cytochrome c/dATP-dependent fashion.	2'-deoxyadenosine triphosphate	101-105	cytochrome c, somatic	Homo sapiens	88-100
10722681-7	2000	Functional analysis of all identified Apaf-1 isoforms demonstrated that only those with the additional WD-40 repeat activated procaspase 9 in vitro in response to cytochrome c and dATP, while the NH(2)-terminal insert was not required for this activity.	2'-deoxyadenosine triphosphate	180-184	apoptotic peptidase activating factor 1	Homo sapiens	38-44
10692394-4	2000	We now demonstrate that dATP activation of cell lysates results in the formation of two large Apaf-1-containing apoptosome complexes with M(r) values of approximately 1.4 MDa and approximately 700 kDa.	2'-deoxyadenosine triphosphate	24-28	apoptotic peptidase activating factor 1	Homo sapiens	94-100
10671558-8	2000	Furthermore, direct cleavage of caspase-9 by calpain blocks dATP and cytochrome-c induced caspase-3 activation.	2'-deoxyadenosine triphosphate	60-64	caspase 9	Homo sapiens	32-41
10687948-2	2000	When cells receive apoptotic stimuli, mitochondria releases cytochrome c which then binds to Apaf-1, the mammalian Ced-4 homologue, together with dATP.	2'-deoxyadenosine triphosphate	146-150	cytochrome c, somatic	Homo sapiens	60-72
10687948-2	2000	When cells receive apoptotic stimuli, mitochondria releases cytochrome c which then binds to Apaf-1, the mammalian Ced-4 homologue, together with dATP.	2'-deoxyadenosine triphosphate	146-150	apoptotic peptidase activating factor 1	Homo sapiens	115-120
10617581-2	2000	We previously demonstrated that that the 5"-triphosphate metabolite of 2CdA (2CdATP), similar to dATP, can cooperate with cytochrome c and apoptosis protein-activating factor-1 (APAF-1) to trigger a caspase pathway in a HeLa cell-free system.	2'-deoxyadenosine triphosphate	79-83	cytochrome c, somatic	Homo sapiens	122-134
10617581-2	2000	We previously demonstrated that that the 5"-triphosphate metabolite of 2CdA (2CdATP), similar to dATP, can cooperate with cytochrome c and apoptosis protein-activating factor-1 (APAF-1) to trigger a caspase pathway in a HeLa cell-free system.	2'-deoxyadenosine triphosphate	79-83	apoptotic peptidase activating factor 1	Homo sapiens	139-176
10617581-2	2000	We previously demonstrated that that the 5"-triphosphate metabolite of 2CdA (2CdATP), similar to dATP, can cooperate with cytochrome c and apoptosis protein-activating factor-1 (APAF-1) to trigger a caspase pathway in a HeLa cell-free system.	2'-deoxyadenosine triphosphate	79-83	apoptotic peptidase activating factor 1	Homo sapiens	178-184
10428844-3	1999	Immunoblotting revealed that incubation of HL-60 cytosol at 30 degrees C in the presence of cytochrome c and ATP (or dATP) resulted in activation of procaspases-3, -6, and -7 but not -2 and -8.	2'-deoxyadenosine triphosphate	117-121	caspase 3	Homo sapiens	149-174
10619022-2	1999	Like mammalian APAF-1, HAC-1 can activate caspases in a dATP-dependent manner in vitro.	2'-deoxyadenosine triphosphate	56-60	apoptotic peptidase activating factor 1	Homo sapiens	15-21
10619022-2	1999	Like mammalian APAF-1, HAC-1 can activate caspases in a dATP-dependent manner in vitro.	2'-deoxyadenosine triphosphate	56-60	tripartite motif containing 3	Homo sapiens	23-28
10646859-6	2000	Biochemically, the intracellular ratio of dATP:dTTP increased substantially in JH-1 cells as cells progressed into early S-phase compared with JH-2 cells, which remained in G1 phase.	2'-deoxyadenosine triphosphate	42-46	immunoglobulin heavy joining 1	Homo sapiens	79-83
10646859-10	2000	Both JH-1 and JH-2 cells, synchronized in late G1 and following growth stimulation, now progressed into S-phase identically (<24 h), with similarly increased dATP:dTTP ratios under dThd withdrawal conditions.	2'-deoxyadenosine triphosphate	161-165	immunoglobulin heavy joining 2	Homo sapiens	14-18
10544189-9	1999	We conclude that HSP27 inhibits etoposide-induced apoptosis by preventing cytochrome c and dATP-triggered activity of caspase-9, downstream of cytochrome c release.	2'-deoxyadenosine triphosphate	91-95	heat shock protein family B (small) member 1	Homo sapiens	17-22
10544189-9	1999	We conclude that HSP27 inhibits etoposide-induced apoptosis by preventing cytochrome c and dATP-triggered activity of caspase-9, downstream of cytochrome c release.	2'-deoxyadenosine triphosphate	91-95	caspase 9	Homo sapiens	118-127
10544189-9	1999	We conclude that HSP27 inhibits etoposide-induced apoptosis by preventing cytochrome c and dATP-triggered activity of caspase-9, downstream of cytochrome c release.	2'-deoxyadenosine triphosphate	91-95	cytochrome c, somatic	Homo sapiens	143-155
10428844-5	1999	ATP and dATP levels in intact HL-60 cells were higher than required for caspase activation in vitro and did not change before caspase activation in situ.	2'-deoxyadenosine triphosphate	8-12	caspase 6	Homo sapiens	72-79
10364241-4	1999	However, when dATP is added to the cytochrome c-bound Apaf-1 complex, complete oligomerization occurs, suggesting that oligomerization is driven by hydrolysis of dATP.	2'-deoxyadenosine triphosphate	14-18	cytochrome c, somatic	Homo sapiens	35-47
10409627-4	1999	Apaf-1 dimerization was repressed by the C-terminal half of the molecule, which contains multiple WD-40 repeats, but this repression was overcome in the presence of cytochrome c and dATP.	2'-deoxyadenosine triphosphate	182-186	apoptotic peptidase activating factor 1	Homo sapiens	0-6
10393175-0	1999	Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis.	2'-deoxyadenosine triphosphate	25-29	apoptotic peptidase activating factor 1	Homo sapiens	48-54
10393175-0	1999	Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis.	2'-deoxyadenosine triphosphate	25-29	caspase 9	Homo sapiens	64-73
10393175-3	1999	The product of this Apaf-1 cDNA activated procaspase-9 in a cytochrome c and dATP/ATP-dependent manner.	2'-deoxyadenosine triphosphate	77-81	apoptotic peptidase activating factor 1	Homo sapiens	20-26
10393175-4	1999	We used this Apaf-1 to show that Apaf-1 requires dATP/ATP hydrolysis to interact with cytochrome c, self-associate and bind to procaspase-9.	2'-deoxyadenosine triphosphate	49-53	apoptotic peptidase activating factor 1	Homo sapiens	13-19
10393175-4	1999	We used this Apaf-1 to show that Apaf-1 requires dATP/ATP hydrolysis to interact with cytochrome c, self-associate and bind to procaspase-9.	2'-deoxyadenosine triphosphate	49-53	apoptotic peptidase activating factor 1	Homo sapiens	33-39
10393175-4	1999	We used this Apaf-1 to show that Apaf-1 requires dATP/ATP hydrolysis to interact with cytochrome c, self-associate and bind to procaspase-9.	2'-deoxyadenosine triphosphate	49-53	cytochrome c, somatic	Homo sapiens	86-98
10373420-0	1999	The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein.	2'-deoxyadenosine triphosphate	22-26	nudix hydrolase 1	Homo sapiens	76-81
10373420-2	1999	We report here that hMTH1 hydrolyzed 2-hydroxy-dATP (2-OH-dATP) and 8-hydroxy-dATP (8-OH-dATP), oxidized forms of dATP, but not (R)-8,5"-cyclo-dATP, 5-hydroxy-dCTP, and 5-formyl-dUTP.	2'-deoxyadenosine triphosphate	47-51	nudix hydrolase 1	Homo sapiens	20-25
10393175-6	1999	Mutation of Met368 to Leu enabled Apaf-1 to self-associate and bind procaspase-9 independent of cytochrome c, though still requiring dATP/ATP for these activities.	2'-deoxyadenosine triphosphate	133-137	apoptotic peptidase activating factor 1	Homo sapiens	34-40
10364241-4	1999	However, when dATP is added to the cytochrome c-bound Apaf-1 complex, complete oligomerization occurs, suggesting that oligomerization is driven by hydrolysis of dATP.	2'-deoxyadenosine triphosphate	14-18	apoptotic peptidase activating factor 1	Homo sapiens	54-60
10364241-4	1999	However, when dATP is added to the cytochrome c-bound Apaf-1 complex, complete oligomerization occurs, suggesting that oligomerization is driven by hydrolysis of dATP.	2'-deoxyadenosine triphosphate	162-166	cytochrome c, somatic	Homo sapiens	35-47
10364241-4	1999	However, when dATP is added to the cytochrome c-bound Apaf-1 complex, complete oligomerization occurs, suggesting that oligomerization is driven by hydrolysis of dATP.	2'-deoxyadenosine triphosphate	162-166	apoptotic peptidase activating factor 1	Homo sapiens	54-60
10336418-6	1999	Interestingly, we found that DNA duplex was unwound by the recombinant TIP49a in the presence of ATP or dATP.	2'-deoxyadenosine triphosphate	104-108	RuvB-like AAA ATPase 1	Rattus norvegicus	71-77
10369688-10	1999	Bypass DNA synthesis by the XP-V polymerase occurred only in the presence of dATP, indicating that it can incorporate only dATP to bypass a di-thymine lesion.	2'-deoxyadenosine triphosphate	77-81	DNA polymerase eta	Homo sapiens	28-32
10369688-10	1999	Bypass DNA synthesis by the XP-V polymerase occurred only in the presence of dATP, indicating that it can incorporate only dATP to bypass a di-thymine lesion.	2'-deoxyadenosine triphosphate	123-127	DNA polymerase eta	Homo sapiens	28-32
10231368-1	1999	The RecA protein requires ATP or dATP for its coprotease and strand exchange activities.	2'-deoxyadenosine triphosphate	33-37	RAD51 recombinase	Homo sapiens	4-8
10206961-2	1999	APAF-1 binds and hydrolyzes ATP or dATP to ADP or dADP, respectively.	2'-deoxyadenosine triphosphate	35-39	apoptotic peptidase activating factor 1	Homo sapiens	0-6
10085063-1	1999	The recombinant form of the proapoptotic caspase-9 purified following expression in Escherichia coli is processed at Asp315, but largely inactive; however, when added to cytosolic extracts of human 293 cells it is activated 2000-fold in the presence of cytochrome c and dATP.	2'-deoxyadenosine triphosphate	270-274	caspase 9	Homo sapiens	41-50
10206961-3	1999	The hydrolysis of ATP/dATP and the binding of cytochrome c promote APAF-1 oligomerization, forming a large multimeric APAF-1.cytochrome c complex.	2'-deoxyadenosine triphosphate	22-26	apoptotic peptidase activating factor 1	Homo sapiens	67-73
10206961-3	1999	The hydrolysis of ATP/dATP and the binding of cytochrome c promote APAF-1 oligomerization, forming a large multimeric APAF-1.cytochrome c complex.	2'-deoxyadenosine triphosphate	22-26	apoptotic peptidase activating factor 1	Homo sapiens	118-124
10206961-3	1999	The hydrolysis of ATP/dATP and the binding of cytochrome c promote APAF-1 oligomerization, forming a large multimeric APAF-1.cytochrome c complex.	2'-deoxyadenosine triphosphate	22-26	cytochrome c, somatic	Homo sapiens	125-137
10205158-7	1999	In in vitro systems, recombinant Hsp60 and Hsp10 accelerated the activation of pro-caspase-3 by cytochrome c and dATP in an ATP-dependent manner, consistent with their function as chaperones.	2'-deoxyadenosine triphosphate	113-117	heat shock protein family D (Hsp60) member 1	Homo sapiens	33-38
10205158-7	1999	In in vitro systems, recombinant Hsp60 and Hsp10 accelerated the activation of pro-caspase-3 by cytochrome c and dATP in an ATP-dependent manner, consistent with their function as chaperones.	2'-deoxyadenosine triphosphate	113-117	heat shock protein family E (Hsp10) member 1	Homo sapiens	43-48
10205158-7	1999	In in vitro systems, recombinant Hsp60 and Hsp10 accelerated the activation of pro-caspase-3 by cytochrome c and dATP in an ATP-dependent manner, consistent with their function as chaperones.	2'-deoxyadenosine triphosphate	113-117	caspase 3	Homo sapiens	79-92
10021389-7	1999	Addition of dATP (which stimulates the procaspase-processing factor Apaf-1 [8] [9]) overcame inhibition of caspase activation by Bcl-2, but did not prevent the control of cytochrome c release from mitochondria by Bcl-2.	2'-deoxyadenosine triphosphate	12-16	apoptotic peptidase activating factor 1	Homo sapiens	68-74
10079104-4	1999	Exposure of the transfected cells to 2"-deoxyadenosine and an ADA inhibitor increased the dATP pool and resulted in a marked increase in A-T insertions at recombination junctions, with an overall decreased frequency of V(D)J recombination.	2'-deoxyadenosine triphosphate	90-94	adenosine deaminase	Homo sapiens	62-65
10021389-7	1999	Addition of dATP (which stimulates the procaspase-processing factor Apaf-1 [8] [9]) overcame inhibition of caspase activation by Bcl-2, but did not prevent the control of cytochrome c release from mitochondria by Bcl-2.	2'-deoxyadenosine triphosphate	12-16	BCL2 apoptosis regulator	Homo sapiens	129-134
10021389-7	1999	Addition of dATP (which stimulates the procaspase-processing factor Apaf-1 [8] [9]) overcame inhibition of caspase activation by Bcl-2, but did not prevent the control of cytochrome c release from mitochondria by Bcl-2.	2'-deoxyadenosine triphosphate	12-16	BCL2 apoptosis regulator	Homo sapiens	213-218
9787175-0	1998	Human monocytoid leukemia cells are highly sensitive to apoptosis induced by 2"-deoxycoformycin and 2"-deoxyadenosine: association with dATP-dependent activation of caspase-3.	2'-deoxyadenosine triphosphate	136-140	caspase 3	Homo sapiens	165-174
9826508-5	1998	Active nucleotides (ATP, dATP) changed the DNA binding mode of XRad51.1.	2'-deoxyadenosine triphosphate	25-29	RAD51 recombinase S homeolog	Xenopus laevis	63-71
9826508-7	1998	Dissociation of XRad51.1 from DNA was accelerated by ATP and dATP, as was dissociation of RecA from DNA.	2'-deoxyadenosine triphosphate	61-65	RAD51 recombinase S homeolog	Xenopus laevis	16-24
10611963-9	1999	This pathway is regulated at several steps, including the release of cytochrome c from the mitochondria, the binding and hydrolysis of dATP/ATP by Apaf-1, and the inhibition of caspase activation by the proteins that belong to the inhibitors of apoptosis (IAP).	2'-deoxyadenosine triphosphate	135-139	cytochrome c, somatic	Homo sapiens	69-81
10611963-9	1999	This pathway is regulated at several steps, including the release of cytochrome c from the mitochondria, the binding and hydrolysis of dATP/ATP by Apaf-1, and the inhibition of caspase activation by the proteins that belong to the inhibitors of apoptosis (IAP).	2'-deoxyadenosine triphosphate	135-139	apoptotic peptidase activating factor 1	Homo sapiens	147-153
10611963-9	1999	This pathway is regulated at several steps, including the release of cytochrome c from the mitochondria, the binding and hydrolysis of dATP/ATP by Apaf-1, and the inhibition of caspase activation by the proteins that belong to the inhibitors of apoptosis (IAP).	2'-deoxyadenosine triphosphate	135-139	caspase 6	Homo sapiens	177-184
9787175-10	1998	However, dATP effectively induced CPP32 activation in cytosol from monocytoid cells, but not in that from nonmonocytoid cells, suggesting that dATP-dependent CPP32 activation is at least partly involved in the preferential induction of apoptosis in monocytoid leukemia cells.	2'-deoxyadenosine triphosphate	143-147	caspase 3	Homo sapiens	34-39
9787175-10	1998	However, dATP effectively induced CPP32 activation in cytosol from monocytoid cells, but not in that from nonmonocytoid cells, suggesting that dATP-dependent CPP32 activation is at least partly involved in the preferential induction of apoptosis in monocytoid leukemia cells.	2'-deoxyadenosine triphosphate	9-13	caspase 3	Homo sapiens	34-39
9787175-10	1998	However, dATP effectively induced CPP32 activation in cytosol from monocytoid cells, but not in that from nonmonocytoid cells, suggesting that dATP-dependent CPP32 activation is at least partly involved in the preferential induction of apoptosis in monocytoid leukemia cells.	2'-deoxyadenosine triphosphate	143-147	caspase 3	Homo sapiens	158-163
9787175-10	1998	However, dATP effectively induced CPP32 activation in cytosol from monocytoid cells, but not in that from nonmonocytoid cells, suggesting that dATP-dependent CPP32 activation is at least partly involved in the preferential induction of apoptosis in monocytoid leukemia cells.	2'-deoxyadenosine triphosphate	9-13	caspase 3	Homo sapiens	158-163
9753651-4	1998	The dATP-dependent and swelling-independent release of cytochrome c from mitochondria is not inhibitable by the protease inhibitor z-VAD, suggesting that it is not mediated by upstream caspases.	2'-deoxyadenosine triphosphate	4-8	cytochrome c, somatic	Homo sapiens	55-67
9756935-4	1998	ATP and dATP, the only nucleotides hydrolyzed by Dna2, served to stimulate Dna2 to utilize duplex DNA, indicating their hydrolysis is required.	2'-deoxyadenosine triphosphate	8-12	bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2	Saccharomyces cerevisiae S288C	49-53
9756935-4	1998	ATP and dATP, the only nucleotides hydrolyzed by Dna2, served to stimulate Dna2 to utilize duplex DNA, indicating their hydrolysis is required.	2'-deoxyadenosine triphosphate	8-12	bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2	Saccharomyces cerevisiae S288C	75-79
9753651-0	1998	dATP causes specific release of cytochrome C from mitochondria.	2'-deoxyadenosine triphosphate	0-4	cytochrome c, somatic	Homo sapiens	32-44
9753651-3	1998	By contrast, it was observed that dATP is a potent inducer that caused release of cytochrome c in a swelling independent manner, i.e. even in the presence of osmotic support by PEG-1000; in addition this release of cytochrome c is inhibitable by cyclosporin A.	2'-deoxyadenosine triphosphate	34-38	cytochrome c, somatic	Homo sapiens	82-94
9753651-3	1998	By contrast, it was observed that dATP is a potent inducer that caused release of cytochrome c in a swelling independent manner, i.e. even in the presence of osmotic support by PEG-1000; in addition this release of cytochrome c is inhibitable by cyclosporin A.	2'-deoxyadenosine triphosphate	34-38	cytochrome c, somatic	Homo sapiens	215-227
9611231-4	1998	Hydrolysis of dATP or ATP, and to a lesser extent hydrolysis of dCTP or CTP, supports WRN-catalyzed strand-displacement.	2'-deoxyadenosine triphosphate	14-18	WRN RecQ like helicase	Homo sapiens	86-89
9689121-3	1998	The present experiments demonstrate that the 5"-triphosphate metabolite of 2CdA (2CdA-5"-triphosphate), similar to dATP, can cooperate with cytochrome c and Apaf-1 to activate caspase-3 in a cell free system.	2'-deoxyadenosine triphosphate	115-119	cytochrome c, somatic	Homo sapiens	140-152
9689121-3	1998	The present experiments demonstrate that the 5"-triphosphate metabolite of 2CdA (2CdA-5"-triphosphate), similar to dATP, can cooperate with cytochrome c and Apaf-1 to activate caspase-3 in a cell free system.	2'-deoxyadenosine triphosphate	115-119	apoptotic peptidase activating factor 1	Homo sapiens	157-163
9689121-3	1998	The present experiments demonstrate that the 5"-triphosphate metabolite of 2CdA (2CdA-5"-triphosphate), similar to dATP, can cooperate with cytochrome c and Apaf-1 to activate caspase-3 in a cell free system.	2'-deoxyadenosine triphosphate	115-119	caspase 3	Homo sapiens	176-185
9722988-7	1998	However, CdA induces major depletions of dTTP, dGTP and dATP in CCRF-CEM cells and F-Ara-A induces a major accumulation of dATP in Raji cells.	2'-deoxyadenosine triphosphate	56-60	cytidine deaminase	Homo sapiens	9-12
9345319-3	1997	L-dCTP inhibited dCK non-competitively with 2"-deoxycytidine (D-dCyd) and competitively with phosphate donor D-ATP.	2'-deoxyadenosine triphosphate	109-114	sticky	Drosophila melanogaster	17-20
9592148-5	1998	The purified, recombinant AtDRH1 was capable of unwinding double-stranded RNA in the presence of ATP or dATP and of hydrolyzing ATP.	2'-deoxyadenosine triphosphate	104-108	DEAD box RNA helicase 1	Arabidopsis thaliana	26-32
9545297-4	1998	In the presence of ATP or dATP, unwinding of duplex DNA or a DNA-RNA heteroduplex by the recombinant Sgs1 fragment was readily observed.	2'-deoxyadenosine triphosphate	26-30	ATP-dependent DNA helicase SGS1	Saccharomyces cerevisiae S288C	101-105
9598997-1	1998	Previous studies have shown that Apaf-1 and caspase-9 in the presence of cytochrome c and dATP can form an initiating complex for an apoptotic protease cascade.	2'-deoxyadenosine triphosphate	90-94	apoptotic peptidase activating factor 1	Homo sapiens	33-39
9598997-1	1998	Previous studies have shown that Apaf-1 and caspase-9 in the presence of cytochrome c and dATP can form an initiating complex for an apoptotic protease cascade.	2'-deoxyadenosine triphosphate	90-94	caspase 9	Homo sapiens	44-53
9634002-9	1998	In contrast, a profound inhibition of dCTP and a decreased sensitivity to dATP inhibition was observed in M2-D, X-D, and HUR clones.	2'-deoxyadenosine triphosphate	74-78	ELAV like RNA binding protein 1	Homo sapiens	121-124
9463483-6	1998	A marked increase in the dATP to dTTP ratio was seen with FUra with or without IFN-alpha + gamma.	2'-deoxyadenosine triphosphate	25-29	interferon alpha 1	Homo sapiens	79-88
9395538-4	1997	We show here that the transcript release activity of factor 2 requires ATP or dATP and that adenosine 5"-O-(thiotriphosphate) (ATPgammaS), adenosine 5"-(beta,gamma-imino)triphosphate (AMP-PNP), or other NTPs do not support the activity.	2'-deoxyadenosine triphosphate	78-82	lodestar	Drosophila melanogaster	53-61
9361033-4	1997	In general, severity of disease correlates inversely with the amount of residual ADA expressed by the mutant enzymes and directly with the accumulation of the toxic metabolites deoxyATP and deoxyadenosine.	2'-deoxyadenosine triphosphate	177-185	adenosine deaminase	Homo sapiens	81-84
9390557-3	1997	Caspase-9 and Apaf-1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome c and dATP, an event that leads to caspase-9 activation.	2'-deoxyadenosine triphosphate	135-139	caspase 9	Homo sapiens	0-9
9390557-3	1997	Caspase-9 and Apaf-1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome c and dATP, an event that leads to caspase-9 activation.	2'-deoxyadenosine triphosphate	135-139	apoptotic peptidase activating factor 1	Homo sapiens	14-20
9390557-3	1997	Caspase-9 and Apaf-1 bind to each other via their respective NH2-terminal CED-3 homologous domains in the presence of cytochrome c and dATP, an event that leads to caspase-9 activation.	2'-deoxyadenosine triphosphate	135-139	caspase 9	Homo sapiens	164-173
9390557-6	1997	Mutation of the active site of caspase-9 attenuated the activation of caspase-3 and cellular apoptotic response in vivo, indicating that caspase-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP.	2'-deoxyadenosine triphosphate	247-251	caspase 9	Homo sapiens	31-40
9390557-6	1997	Mutation of the active site of caspase-9 attenuated the activation of caspase-3 and cellular apoptotic response in vivo, indicating that caspase-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP.	2'-deoxyadenosine triphosphate	247-251	caspase 3	Homo sapiens	70-79
9390557-6	1997	Mutation of the active site of caspase-9 attenuated the activation of caspase-3 and cellular apoptotic response in vivo, indicating that caspase-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP.	2'-deoxyadenosine triphosphate	247-251	caspase 9	Homo sapiens	137-146
9390557-6	1997	Mutation of the active site of caspase-9 attenuated the activation of caspase-3 and cellular apoptotic response in vivo, indicating that caspase-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP.	2'-deoxyadenosine triphosphate	247-251	cytochrome c, somatic	Homo sapiens	230-242
9305914-8	1997	Displacement of DNA fragments by the DNA helicase suggested that it migrated along single-stranded DNA in the 3" to 5" direction, and the DNA helicase activity was detected only in the presence of hydrolyzable ATP or dATP.	2'-deoxyadenosine triphosphate	217-221	helicase for meiosis 1	Homo sapiens	41-49
9305914-8	1997	Displacement of DNA fragments by the DNA helicase suggested that it migrated along single-stranded DNA in the 3" to 5" direction, and the DNA helicase activity was detected only in the presence of hydrolyzable ATP or dATP.	2'-deoxyadenosine triphosphate	217-221	helicase for meiosis 1	Homo sapiens	142-150
9288776-5	1997	Synergy between butyrate and staurosporine was due to the presence of a factor in the cytosol of butyrate-primed cells which enhanced over 7-fold the activation of caspase-3 induced by the addition of cytochrome c and dATP to isolated cytosol.	2'-deoxyadenosine triphosphate	218-222	caspase 3	Homo sapiens	164-173
9048887-8	1997	An3 protein was able to resolve the duplex formed by an in vitro substrate, in the presence of ATP or dATP.	2'-deoxyadenosine triphosphate	102-106	DEAD-box helicase 3 X-linked S homeolog	Xenopus laevis	0-3
9364479-1	1997	Highly abundant, saturable and specific binding sites for [35S]2"-deoxyadenosine 5"-O-(1-thio) triphosphate ([35S]dATP alpha S, Kd: 9 +/- 2 nM; Bmax: 39 +/- 8 pmol/mg protein) are present in adult rat brain membranes and have characteristics consistent with those expected for a P2Y1 receptor.	2'-deoxyadenosine triphosphate	114-118	purinergic receptor P2Y1	Rattus norvegicus	279-283
9277354-4	1997	Nuclear proteins from flow-conditioned human aortic endothelial cells (HAEC) were analyzed by electrophoretic mobility shift assay using [gamma-32P]dATP-labeled NF-kappa B-specific oligonucleotide.	2'-deoxyadenosine triphosphate	148-152	nuclear factor kappa B subunit 1	Homo sapiens	161-171
9240460-1	1997	An orphan G protein-coupled receptor, termed 6H1, with approximately 30% sequence identity to P2Y receptors has been proposed to be a P2Y receptor (p2y5) based solely on a radioligand binding assay with [35S]dATP alphaS [Webb et al.	2'-deoxyadenosine triphosphate	208-212	lysophosphatidic acid receptor 6	Homo sapiens	148-152
9276690-2	1997	For all the enzymes examined except firefly luciferase (including hexokinase, polynucleotide kinase, T4 DNA ligase, and T4 RNA ligase) ATP could be replaced with dATP, contradicting previous data.	2'-deoxyadenosine triphosphate	162-166	hexokinase 1	Homo sapiens	66-76
9207227-1	1997	A recently cloned G protein-coupled receptor (named the p2y7 receptor) with relatively low sequence identity to previously cloned P2Y receptors was proposed to be a member of this family of receptors on the basis of both a radioligand binding assay with [35S]dATP alphaS and an inositol phosphate response to ATP in COS-7 cells transiently transfected with receptor cDNA.	2'-deoxyadenosine triphosphate	259-263	leukotriene B4 receptor	Homo sapiens	56-60
8841119-5	1996	Non-template-directed nucleotidyl transfer is also observed when pol beta-DNA cocrystals are soaked in the presence of dATP and Zn2+, but the reaction products differ in that the sugar moiety of the incorporated nucleotide appears distorted or otherwise cleaved, in agreement with reports that Zn2+ may act as a polymerase inhibitor rather than as a mutagen [Sirover, M. A., & Loeb, L. A.	2'-deoxyadenosine triphosphate	119-123	DNA polymerase beta	Homo sapiens	65-73
8798731-2	1996	The product of the Escherichia coli orf17 gene is a novel nucleoside triphosphate pyrophosphohydrolase with a preference for dATP over the other canonical (deoxy)nucleoside triphosphates, and it catalyzes the hydrolysis of dATP through a nucleophilic attack at the beta-phosphorus to produce dAMP and inorganic pyrophosphate.	2'-deoxyadenosine triphosphate	125-129	putative transposase	Escherichia coli	36-41
8798731-2	1996	The product of the Escherichia coli orf17 gene is a novel nucleoside triphosphate pyrophosphohydrolase with a preference for dATP over the other canonical (deoxy)nucleoside triphosphates, and it catalyzes the hydrolysis of dATP through a nucleophilic attack at the beta-phosphorus to produce dAMP and inorganic pyrophosphate.	2'-deoxyadenosine triphosphate	223-227	putative transposase	Escherichia coli	36-41
9016352-8	1997	The human P2X4 receptor displays a very similar agonist potency profile to that of rat P2X4 (ATP > > 2-methylthio-ATP > or = CTP > alpha, beta-methylene-ATP > dATP) but has a notably higher sensitivity for the antagonists suramin, pyridoxal-phosphate-6-azophenyl-2",4"-disulfonic acid, and bromphenol blue.	2'-deoxyadenosine triphosphate	174-178	purinergic receptor P2X 4	Rattus norvegicus	10-14
8663040-5	1996	Mice with limited ADA expression exhibited profound disturbances in purine metabolism, including thymus-specific accumulations of deoxyadenosine and dATP, and inhibition of S-adenosylhomocysteine hydrolase in the thymus, spleen, and, to a lesser extent, the liver.	2'-deoxyadenosine triphosphate	149-153	adenosine deaminase	Mus musculus	18-21
8674058-7	1996	In vitro DNA primer extension assays indicated that Cl-F-ara-ATP competed with dATP for incorporation into A sites of the extending DNA strand catalyzed by both human DNA polymerases alpha and epsilon.	2'-deoxyadenosine triphosphate	79-83	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	167-188
8687383-2	1996	In haemopoietic BAF3 cells, IL-3 withdrawal leads to a rapid decrease in the size of dATP, dTTP and dGTP pools without affecting dCTP levels.	2'-deoxyadenosine triphosphate	85-89	interleukin 3	Mus musculus	28-32
7698229-10	1995	Our experiments also revealed that apart from binding ATP and G-rich DNA, nucleolin directly bound GTP, dATP, and dGTP, but not dCTP, dTTP, or dUTP.	2'-deoxyadenosine triphosphate	104-108	nucleolin	Mus musculus	74-83
8636980-4	1996	In the presence of dATP, mixed filaments are formed on dsDNA or ssDNA in which the RecA K72R content approximately reflects the proportion of the K72R mutant in the total RecA protein present when the filament is formed.	2'-deoxyadenosine triphosphate	19-23	RAD51 recombinase	Homo sapiens	83-87
8636980-4	1996	In the presence of dATP, mixed filaments are formed on dsDNA or ssDNA in which the RecA K72R content approximately reflects the proportion of the K72R mutant in the total RecA protein present when the filament is formed.	2'-deoxyadenosine triphosphate	19-23	RAD51 recombinase	Homo sapiens	171-175
8621437-6	1996	With RecA K72R protein, the formation of the hybrid DNA product of strand exchange is greatly affected by the concentration of Mg2+ in ways that reflect the concentration of a Mg.dATP complex.	2'-deoxyadenosine triphosphate	179-183	RAD51 recombinase	Homo sapiens	5-9
8823494-5	1996	The addition of IFN to 5FU resulted in greater depletion of dTTP levels over treatment with 5FU alone by up to fourfold, and markedly augmented the dATP/dTTP ratio.	2'-deoxyadenosine triphosphate	148-152	interferon alpha 1	Homo sapiens	16-19
7782501-5	1995	Double label in situ hybridization with 35S-dATP- and digoxygenin-dUTP-tailed oligonucleotide probes demonstrated that mGluR5 message is highly expressed by enkephalinergic striatal neurons but is not detectable in cholinergic or somatostatin interneurons.	2'-deoxyadenosine triphosphate	44-48	glutamate receptor, ionotropic, kainate 1	Mus musculus	119-125
7547923-7	1995	Second, binding of the ATP analogues AMP-PNP, dATP, and ATP gamma S to nucleotide-free hsc70 had very little further effect on the properties of the nucleotide-free hsc70.	2'-deoxyadenosine triphosphate	46-50	heat shock protein family A (Hsp70) member 8	Homo sapiens	87-92
7702640-0	1995	5,10-Dideazatetrahydrofolic acid reduces toxicity and deoxyadenosine triphosphate pool, expansion in cultured L1210 cells treated with inhibitors of thymidylate synthase.	2'-deoxyadenosine triphosphate	54-81	thymidylate synthase	Mus musculus	149-169
7567152-2	1995	Two 20-base oligomers complementary to bases 872-891 of human p53 cDNA with a single nucleotide difference in the third position of codon 249 were end-labelled with biotin-conjugated dATP using terminal deoxynucleotidyltransferase (TdT).	2'-deoxyadenosine triphosphate	183-187	tumor protein p53	Homo sapiens	62-65
7567152-2	1995	Two 20-base oligomers complementary to bases 872-891 of human p53 cDNA with a single nucleotide difference in the third position of codon 249 were end-labelled with biotin-conjugated dATP using terminal deoxynucleotidyltransferase (TdT).	2'-deoxyadenosine triphosphate	183-187	DNA nucleotidylexotransferase	Homo sapiens	194-230
17180017-5	1995	The Cl-dATP/dATP ratio was 0.03 in Cl-dA treated 697/Bcl 2 cells but nearly 6 in treated 697 cells.	2'-deoxyadenosine triphosphate	7-11	BCL2 apoptosis regulator	Homo sapiens	53-58
7540049-2	1995	To demonstrate DSB, biotin-labeled and unlabeled dATPs with terminal deoxynucleotidyl transferase (TdT) were added to the many 3-hydroxyl termini of DNA fragments generated in the apoptotic cells.	2'-deoxyadenosine triphosphate	49-54	DNA nucleotidylexotransferase	Homo sapiens	60-97
7540049-2	1995	To demonstrate DSB, biotin-labeled and unlabeled dATPs with terminal deoxynucleotidyl transferase (TdT) were added to the many 3-hydroxyl termini of DNA fragments generated in the apoptotic cells.	2'-deoxyadenosine triphosphate	49-54	DNA nucleotidylexotransferase	Homo sapiens	99-102
7737162-6	1995	PC-1 was also labeled with [alpha-32P]ATP and [35S]dATP[alpha S].	2'-deoxyadenosine triphosphate	51-55	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	0-4
17180017-6	1995	Bcl 2 overproduction also suppressed the accumulation of dAMP, dADP and dATP in cells exposed to 2"-deoxyadenosine in the presence of pentostatin to abrogate the pronounced inversion of ATP/dATP pools associated with 2"-deoxyadenosine exposure.	2'-deoxyadenosine triphosphate	72-76	BCL2 apoptosis regulator	Homo sapiens	0-5
17180017-6	1995	Bcl 2 overproduction also suppressed the accumulation of dAMP, dADP and dATP in cells exposed to 2"-deoxyadenosine in the presence of pentostatin to abrogate the pronounced inversion of ATP/dATP pools associated with 2"-deoxyadenosine exposure.	2'-deoxyadenosine triphosphate	190-194	BCL2 apoptosis regulator	Homo sapiens	0-5
8056767-8	1994	DNA-dependent ATPase Q1 hydrolyzed ATP and dATP and Q2 hydrolyzed ATP preferentially among the nucleotides tested.	2'-deoxyadenosine triphosphate	43-47	RecQ like helicase	Homo sapiens	0-23
7816611-7	1994	Since dCTP, dATP and dTTP are required for formation of a pTP-CAT initiation intermediate, we explain our results by conformational changes occurring in the polymerase during initiation leading to disruption of both the interaction between the polymerase and NFI as well as the interaction between NFI and the DNA.	2'-deoxyadenosine triphosphate	12-16	nuclear factor I C	Homo sapiens	259-262
7896756-14	1994	For other ATP analogues (dATP, ADP, and dADP), similar spectral changes were observed, and their Kd values ranged from 19 to 54 microM.	2'-deoxyadenosine triphosphate	25-29	ATPase	Escherichia coli	10-13
7952290-2	1994	Hybridization with [35S]dATP-labelled oligonucleotide probes revealed the expression of four of the NMDA receptor subunits (NR1, NR2A, NR2B and NR2C) and three of the high-affinity kainate receptor subunits (KA2, GluR6 and GluR7) in the retina.	2'-deoxyadenosine triphosphate	24-28	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	124-127
7952290-2	1994	Hybridization with [35S]dATP-labelled oligonucleotide probes revealed the expression of four of the NMDA receptor subunits (NR1, NR2A, NR2B and NR2C) and three of the high-affinity kainate receptor subunits (KA2, GluR6 and GluR7) in the retina.	2'-deoxyadenosine triphosphate	24-28	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	129-133
7952290-2	1994	Hybridization with [35S]dATP-labelled oligonucleotide probes revealed the expression of four of the NMDA receptor subunits (NR1, NR2A, NR2B and NR2C) and three of the high-affinity kainate receptor subunits (KA2, GluR6 and GluR7) in the retina.	2'-deoxyadenosine triphosphate	24-28	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	135-139
8163485-8	1994	The Km for the other substrate, DNA initiator (dA)50) in the presence of dATP remained essentially the same as that of wild-type TdT for all mutants except D343E.	2'-deoxyadenosine triphosphate	73-77	DNA nucleotidylexotransferase	Homo sapiens	129-132
8007973-6	1994	The antirepressor first coeluted with TFIIH, was depleted from this fraction by antibodies directed against the TFIIH subunit p62, was dependent on either ATP or dATP, and then was inhibited by the ATP analogs AMP-PNP and ATP gamma S. Relief of HMG2-mediated repression as well as basal promoter function of TFIIH may involve a helicase that coelutes with TFIIH and displays similar nucleotide specificities.	2'-deoxyadenosine triphosphate	162-166	general transcription factor IIH subunit 1	Homo sapiens	38-43
8007973-6	1994	The antirepressor first coeluted with TFIIH, was depleted from this fraction by antibodies directed against the TFIIH subunit p62, was dependent on either ATP or dATP, and then was inhibited by the ATP analogs AMP-PNP and ATP gamma S. Relief of HMG2-mediated repression as well as basal promoter function of TFIIH may involve a helicase that coelutes with TFIIH and displays similar nucleotide specificities.	2'-deoxyadenosine triphosphate	162-166	general transcription factor IIH subunit 1	Homo sapiens	112-117
8007973-6	1994	The antirepressor first coeluted with TFIIH, was depleted from this fraction by antibodies directed against the TFIIH subunit p62, was dependent on either ATP or dATP, and then was inhibited by the ATP analogs AMP-PNP and ATP gamma S. Relief of HMG2-mediated repression as well as basal promoter function of TFIIH may involve a helicase that coelutes with TFIIH and displays similar nucleotide specificities.	2'-deoxyadenosine triphosphate	162-166	nucleoporin 62	Homo sapiens	126-129
8007973-6	1994	The antirepressor first coeluted with TFIIH, was depleted from this fraction by antibodies directed against the TFIIH subunit p62, was dependent on either ATP or dATP, and then was inhibited by the ATP analogs AMP-PNP and ATP gamma S. Relief of HMG2-mediated repression as well as basal promoter function of TFIIH may involve a helicase that coelutes with TFIIH and displays similar nucleotide specificities.	2'-deoxyadenosine triphosphate	162-166	high mobility group box 2	Homo sapiens	245-249
8007973-6	1994	The antirepressor first coeluted with TFIIH, was depleted from this fraction by antibodies directed against the TFIIH subunit p62, was dependent on either ATP or dATP, and then was inhibited by the ATP analogs AMP-PNP and ATP gamma S. Relief of HMG2-mediated repression as well as basal promoter function of TFIIH may involve a helicase that coelutes with TFIIH and displays similar nucleotide specificities.	2'-deoxyadenosine triphosphate	162-166	general transcription factor IIH subunit 1	Homo sapiens	112-117
8007973-6	1994	The antirepressor first coeluted with TFIIH, was depleted from this fraction by antibodies directed against the TFIIH subunit p62, was dependent on either ATP or dATP, and then was inhibited by the ATP analogs AMP-PNP and ATP gamma S. Relief of HMG2-mediated repression as well as basal promoter function of TFIIH may involve a helicase that coelutes with TFIIH and displays similar nucleotide specificities.	2'-deoxyadenosine triphosphate	162-166	general transcription factor IIH subunit 1	Homo sapiens	112-117
7516581-5	1994	The location of Mn2+ and deoxyadenosine triphosphate in pol beta confirms the role of the invariant aspartates in metal ion and deoxynucleoside triphosphate binding.	2'-deoxyadenosine triphosphate	25-52	DNA polymerase beta	Rattus norvegicus	56-64
7873126-2	1994	In situ hybridization experiments, conducted using a [35S]d-ATP-labelled deoxyoligonucleotide probe and a densitometric analysis of autoradiograms, showed that repeated d-amphetamine moderately increased the TH mRNA level (by ca.	2'-deoxyadenosine triphosphate	58-63	tyrosine hydroxylase	Rattus norvegicus	208-210
8380408-3	1993	Helicase activity is coupled to the hydrolysis of ATP or dATP and to a lesser extent to CTP, dCTP, or UTP.	2'-deoxyadenosine triphosphate	57-61	helicase for meiosis 1	Homo sapiens	0-8
8387369-4	1993	Characterization of DNA helicases after further purification on heparin column revealed that the DNA helicase in the DNA polymerase alpha fraction required ATP (or dCTP) in addition to ATP (or dATP).	2'-deoxyadenosine triphosphate	193-197	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	117-137
8287725-1	1993	In this study, [a-32p]dATP labelled probes of c-myc, N-ras and c-erb B genes were employed to perform dot blot hybridisation with DNA extracted from 17 cases of primary ovarian cancer, 3 cases of recurrent ovarian cancer, 2 cases of germ cell ovarian cancer, 5 cases of serous cysadonoma and 4 cases of normal ovarian tissue.	2'-deoxyadenosine triphosphate	22-26	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	46-51
8287725-1	1993	In this study, [a-32p]dATP labelled probes of c-myc, N-ras and c-erb B genes were employed to perform dot blot hybridisation with DNA extracted from 17 cases of primary ovarian cancer, 3 cases of recurrent ovarian cancer, 2 cases of germ cell ovarian cancer, 5 cases of serous cysadonoma and 4 cases of normal ovarian tissue.	2'-deoxyadenosine triphosphate	22-26	NRAS proto-oncogene, GTPase	Homo sapiens	53-58
8364254-11	1993	These results show that cell lines which have increased levels of ribonucleotide reductase activity (HU and ED2) or loss of feedback inhibition by dATP (ED2 and Y8) are still sensitive to dFdCyd.	2'-deoxyadenosine triphosphate	147-151	unconventional SNARE in the ER 1 homolog (S. cerevisiae)	Mus musculus	153-156
1310978-6	1992	ATPase C1 hydrolyzed ATP only among the ribo- and deoxyribonucleoside triphosphates tested, and this fact distinguished ATPase C1 from ATPases B, C2, and C3, because the latter enzymes are capable of hydrolyzing both ATP and dATP.	2'-deoxyadenosine triphosphate	225-229	dynein, axonemal, heavy chain 8	Mus musculus	0-6
1459861-5	1992	A synthetic SVS II oligonucleotide probe was 3" end-labeled (tailed) with either digoxigenin-11-dUTP or [35S]dATP.	2'-deoxyadenosine triphosphate	109-113	semenogelin 1	Rattus norvegicus	12-18
1406581-3	1992	[alpha-32P]ATP was cross-linked to the SopA protein by UV irradiation; this cross-linking was observed only in the presence of magnesium ion, and was competitively inhibited in the presence of non-radioactive ATP, ADP and dATP, but not other NTPs or dNTPs.	2'-deoxyadenosine triphosphate	222-226	plasmid-partitioning protein SopA	Escherichia coli	39-43
1358759-5	1992	Assembling complexes become resistant to regulation by the bound proteins, but activation by UBX is restored upon ATP or dATP addition, and regulation by both proteins is restored after the addition of all four nucleoside triphosphates and transcription initiation.	2'-deoxyadenosine triphosphate	121-125	Ultrabithorax	Drosophila melanogaster	93-96
1310978-6	1992	ATPase C1 hydrolyzed ATP only among the ribo- and deoxyribonucleoside triphosphates tested, and this fact distinguished ATPase C1 from ATPases B, C2, and C3, because the latter enzymes are capable of hydrolyzing both ATP and dATP.	2'-deoxyadenosine triphosphate	225-229	dynein, axonemal, heavy chain 8	Mus musculus	120-126
1310978-6	1992	ATPase C1 hydrolyzed ATP only among the ribo- and deoxyribonucleoside triphosphates tested, and this fact distinguished ATPase C1 from ATPases B, C2, and C3, because the latter enzymes are capable of hydrolyzing both ATP and dATP.	2'-deoxyadenosine triphosphate	225-229	complement C3	Homo sapiens	146-156
1659321-6	1991	Substrate specificity studies show that the relative activity of nucleoside diphosphates (NDP) as phosphate acceptors is in the order of dTDP greater than CDP greater than UDP greater than dUDP greater than GDP greater than or equal to dGDP greater than dCDP greater than dADP greater than ADP; and the relative activity of triphosphate donors is in the order of UTP greater than dTTP greater than CTP greater than dCTP greater than dATP greater than ATP greater than or equal to dGTP greater than GTP.	2'-deoxyadenosine triphosphate	433-437	TAR DNA-binding protein-43 homolog	Drosophila melanogaster	137-141
1730240-5	1992	Both rat liver DNA ligases were inhibited by deoxyadenosinetriphosphate, however this inhibition was competitive with respect to ATP, for DNA ligase I (Ki 22 microM) and non-competitive for the 100-kDa DNA ligase (Ki 170 microM).	2'-deoxyadenosine triphosphate	45-71	DNA ligase 1	Rattus norvegicus	138-150
2369732-4	1990	Six-h incubations with 5, 10, and 20 microM 2"-deoxyadenosine increased dATP pools 4.8-, 8-, and 14.5-fold, respectively, with 59-, 34-, and 43-fold increases in HPRT mutant fractions.	2'-deoxyadenosine triphosphate	72-76	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	162-166
1707752-13	1991	Inhibition of DNA polymerase alpha was competitive with respect to dATP (Ki of 1 microM).	2'-deoxyadenosine triphosphate	67-71	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	14-34
1988950-3	1991	The arrests in the d(TC)n sequences were eliminated when dATP or dGTP was replaced with the analogue 7-deaza dATP or 7-deaza dGTP, respectively, or when the templates were preincubated with the Escherichia coli single-strand binding protein (SSB).	2'-deoxyadenosine triphosphate	57-61	single-strand binding protein	Escherichia coli	211-240
1988950-3	1991	The arrests in the d(TC)n sequences were eliminated when dATP or dGTP was replaced with the analogue 7-deaza dATP or 7-deaza dGTP, respectively, or when the templates were preincubated with the Escherichia coli single-strand binding protein (SSB).	2'-deoxyadenosine triphosphate	57-61	single-strand binding protein	Escherichia coli	242-245
1986259-4	1991	The APRT-deficient subclones were found to have significantly decreased levels of dATP and dTTP nucleotides and decreased levels of all four ribonucleoside triphosphates (ATP, GTP, CTP and UTP) relative to wild-type cells.	2'-deoxyadenosine triphosphate	82-86	adenine phosphoribosyl transferase	Mus musculus	4-8
1680289-6	1991	This mutation in homozygous form appears to be associated with very severe disease, since the patient had perinatal onset of clinical manifestations of SCID, the highest concentration of the toxic metabolite deoxyATP in nine patients studied, and a relatively poor immunologic response during the initial 2 years of therapy with polyethylene glycol-adenosine deaminase.	2'-deoxyadenosine triphosphate	208-216	adenosine deaminase	Homo sapiens	349-368
1911876-0	1991	Deoxyadenosine triphosphate acting as an energy-transferring molecule in adenosine deaminase inhibited human erythrocytes.	2'-deoxyadenosine triphosphate	0-27	adenosine deaminase	Homo sapiens	73-92
1911876-1	1991	Deoxyadenosine triphosphate (dATP) is present in adenosine deaminase (ADA)-deficient or ADA-inhibited human red cells and in the red cells of the opossum Didelphis virginiana.	2'-deoxyadenosine triphosphate	0-27	adenosine deaminase	Homo sapiens	49-68
1911876-1	1991	Deoxyadenosine triphosphate (dATP) is present in adenosine deaminase (ADA)-deficient or ADA-inhibited human red cells and in the red cells of the opossum Didelphis virginiana.	2'-deoxyadenosine triphosphate	29-33	adenosine deaminase	Homo sapiens	49-68
1703021-4	1991	The fraction of primers elongated by pol alpha was reduced by araATP only when elongation was dependent upon the dATP concentration.	2'-deoxyadenosine triphosphate	113-117	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	37-46
2176614-3	1990	In the presence of poly(dT).r(pA)10 template.primer complex and NaF, we observed AMP, ADP, ATP, PPi and dATP to be competitive inhibitors of the FK-catalyzed DNA polymerization.	2'-deoxyadenosine triphosphate	104-108	C-X-C motif chemokine ligand 8	Homo sapiens	64-67
1974653-7	1990	By in situ hybridization with a [35S]dATP-labeled IFN-gamma cDNA probe, only the AGM1-bearing cells were found to contain detectable IFN-gamma gene transcripts.	2'-deoxyadenosine triphosphate	37-41	interferon gamma	Homo sapiens	50-59
2111815-8	1990	Specific complex formation between ATP and eIF-2 is shown 1) by effective retention of Met-tRNAf- and mRNA-binding activities on ATP-agarose and by the ability of free ATP, but not GTP, CTP, or UTP, to effect elution of eIF-2 from this substrate; 2) by eIF-2-dependent retention of [alpha-32P]ATP or dATP on nitrocellulose filters and its inhibition by excess ATP, but not by GTP, CTP, or UTP.	2'-deoxyadenosine triphosphate	300-304	eukaryotic translation initiation factor 2 subunit beta	Homo sapiens	43-48
34860508-6	2021	Results demonstrate that hPol iota primarily incorporates deoxycytidine triphosphate (dCTP) and thymidine triphosphate (dTTP) across from 6-oxo-M1dG with approximately equal efficiency, whereas deoxyadenosine triphosphate (dATP) and deoxyguanosine triphosphate (dGTP) are poor substrates.	2'-deoxyadenosine triphosphate	223-227	DNA polymerase mu	Homo sapiens	25-34
2104881-4	1990	Nuclei from the nonproliferating cells (+/- IL-3) showed essentially no incorporation of [3H]thymidine during a 16-h incubation with a mixture of unlabeled GTP, ATP, UTP, CTP, dGTP, dATP, dCTP, and [3H]dTTP.	2'-deoxyadenosine triphosphate	182-186	interleukin 3	Mus musculus	44-48
2161489-2	1990	In the presence of NaF which is a selective inhibitor of 3"----5"-exonuclease center, AMP is an inhibitor of polymerization competitive with respect to dATP.	2'-deoxyadenosine triphosphate	152-156	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
34546339-7	2022	Additionally, it was observed that DNA polymerase eta inserted dATP opposite guanine in acetaldehyde-treated oligonucleotides, suggesting that acetaldehyde induced GG to TT transversions.	2'-deoxyadenosine triphosphate	63-67	DNA polymerase eta	Homo sapiens	35-53
34188055-2	2021	We present structures of PrimPol insertion complexes with a DNA template-primer and correct dCTP or erroneous dATP opposite the lesion, as well as extension complexes with C or A as a 3"-terminal primer base.	2'-deoxyadenosine triphosphate	110-114	primase and DNA directed polymerase	Homo sapiens	25-32
34145298-3	2021	Here, crystal structures and kinetics of Pol mu substituting dGTP for dATP on gapped DNA substrates containing templating T were determined and compared.	2'-deoxyadenosine triphosphate	70-74	DNA polymerase mu	Homo sapiens	41-47
35170357-4	2022	Here we show that the bifunctional kinase/RNase-IRE1alpha-a central mediator of the unfolded protein response (UPR) to endoplasmic reticulum (ER) stress is a critical promoter of DATP abundance and function.	2'-deoxyadenosine triphosphate	179-183	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	48-57
35610266-4	2022	We show the Rev1 R324 protein-template forms sub-optimal hydrogen bonds with incoming dTTP, dGTP, and dATP that prevents Rev1 from adopting a catalytically competent conformation.	2'-deoxyadenosine triphosphate	102-106	REV1 DNA directed polymerase	Homo sapiens	121-125
35170357-9	2022	Thus, IRE1alpha coordinates a network of stress pathways that conspire to entrap injured cells in the DATP state.	2'-deoxyadenosine triphosphate	102-106	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	6-15
35170357-10	2022	Pharmacologic blockade of IRE1alpha signaling helps resolve the DATP state, thereby ameliorating fibrosis and promoting salutary lung regeneration.	2'-deoxyadenosine triphosphate	64-68	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	26-35
35170357-5	2022	Administration of a nanomolar-potent, mono-selective kinase inhibitor of IRE1alpha (KIRA8)-or conditional epithelial IRE1alpha gene knockout-both reduce DATP cell number and fibrosis in the bleomycin model, indicating that IRE1alpha cell-autonomously promotes transition into the DATP state.	2'-deoxyadenosine triphosphate	280-284	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	73-82
35170357-5	2022	Administration of a nanomolar-potent, mono-selective kinase inhibitor of IRE1alpha (KIRA8)-or conditional epithelial IRE1alpha gene knockout-both reduce DATP cell number and fibrosis in the bleomycin model, indicating that IRE1alpha cell-autonomously promotes transition into the DATP state.	2'-deoxyadenosine triphosphate	280-284	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	117-126
35170357-5	2022	Administration of a nanomolar-potent, mono-selective kinase inhibitor of IRE1alpha (KIRA8)-or conditional epithelial IRE1alpha gene knockout-both reduce DATP cell number and fibrosis in the bleomycin model, indicating that IRE1alpha cell-autonomously promotes transition into the DATP state.	2'-deoxyadenosine triphosphate	280-284	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	223-232
35142337-2	2022	Here, associations between activated endocervical CD4+ T cell numbers and higher deoxyadenosine triphosphate (dATP) concentrations suggest that competition for intracellular metabolites within HIV target cells may reduce the efficacy of antiretroviral-based PrEP in women with GI.	2'-deoxyadenosine triphosphate	81-108	CD4 molecule	Homo sapiens	50-53
35142337-2	2022	Here, associations between activated endocervical CD4+ T cell numbers and higher deoxyadenosine triphosphate (dATP) concentrations suggest that competition for intracellular metabolites within HIV target cells may reduce the efficacy of antiretroviral-based PrEP in women with GI.	2'-deoxyadenosine triphosphate	110-114	CD4 molecule	Homo sapiens	50-53