PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
1874736-8	1991	An inverted repeated ATTTGN2CAAAT (where N is any nucleoside), which most likely represented the XylR recognition sequence, was identified.	Nucleosides	50-60	xylose operon regulatory protein	Pseudomonas putida	97-101
1714958-4	1991	An X-ray diffraction study has revealed that the glycosidic torsion angle of the nucleoside is in the less common syn region and this solid-state geometry is stabilized by a three-dimensional network of self-associated hydrogen-bonded molecules.	Nucleosides	81-91	synemin	Homo sapiens	114-117
1907149-4	1991	Since similar results were obtained with solubilized UDPGT (r2 = 0.87, N = 7), the affinity of the nucleosides for UDPGT was probably being assessed rather than the ability of the compounds to access the membrane-bound enzyme.	Nucleosides	99-110	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	115-120
1929298-1	1991	We describe a novel nucleoside analog, 2"-deoxy-3"-thiacytidine (BCH-189), in which the 3" carbon of the ribose ring of 2"-deoxycytidine has been replaced by a sulfur atom.	Nucleosides	20-30	chimerin 2	Homo sapiens	65-68
1710119-6	1991	In contrast, pyrazofurin and 6-azauridine, two nucleoside analogues that are assumed to interfere with OMP decarboxylase, another enzyme involved in the biosynthesis of pyrimidine ribonucleotides, potentiate the cytocidal activity of Ce-Cyd.	Nucleosides	47-57	olfactory marker protein	Homo sapiens	103-106
2026611-2	1991	The substrate specificity of TK1 and TK2 toward natural substrates and important nucleoside analogues was compared.	Nucleosides	81-91	thymidine kinase 1	Homo sapiens	29-32
2026611-2	1991	The substrate specificity of TK1 and TK2 toward natural substrates and important nucleoside analogues was compared.	Nucleosides	81-91	thymidine kinase 2	Homo sapiens	37-40
2026611-8	1991	The much lower tolerance for modifications of the deoxyribose moiety of TK2 as compared to TK1 is important for the design of new antiviral nucleoside analogues intended for use in cells with different expression of TK1 and TK2.	Nucleosides	140-150	thymidine kinase 2	Homo sapiens	72-75
2026611-8	1991	The much lower tolerance for modifications of the deoxyribose moiety of TK2 as compared to TK1 is important for the design of new antiviral nucleoside analogues intended for use in cells with different expression of TK1 and TK2.	Nucleosides	140-150	thymidine kinase 1	Homo sapiens	91-94
2026611-8	1991	The much lower tolerance for modifications of the deoxyribose moiety of TK2 as compared to TK1 is important for the design of new antiviral nucleoside analogues intended for use in cells with different expression of TK1 and TK2.	Nucleosides	140-150	thymidine kinase 1	Homo sapiens	216-219
2026611-8	1991	The much lower tolerance for modifications of the deoxyribose moiety of TK2 as compared to TK1 is important for the design of new antiviral nucleoside analogues intended for use in cells with different expression of TK1 and TK2.	Nucleosides	140-150	thymidine kinase 2	Homo sapiens	224-227
1707752-6	1991	Competition studies with natural nucleosides suggested that deoxycytidine kinase was the enzyme responsible for the metabolism to the monophosphate.	Nucleosides	33-44	deoxycytidine kinase	Homo sapiens	60-80
1874800-0	1991	Na(+)-dependent, active nucleoside transport in S49 mouse lymphoma cells and loss in AE-1 mutant deficient in facilitated nucleoside transport.	Nucleosides	122-132	solute carrier family 4 (anion exchanger), member 1	Mus musculus	85-89
1874800-5	1991	A nucleoside transport mutant of S49 cells, AE-1, lacked both the NBTI-sensitive, facilitated and Na(+)-dependent, concentrative formycin B transport activity, but Na(+)-dependent, concentrative transport of alpha-aminoisobutyrate was not affected.	Nucleosides	2-12	solute carrier family 4 (anion exchanger), member 1	Mus musculus	44-48
2025274-0	1991	Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs.	Nucleosides	133-143	thymidine kinase 1	Homo sapiens	51-75
2025274-0	1991	Comparison of the substrate specificities of human thymidine kinase 1 and 2 and deoxycytidine kinase toward antiviral and cytostatic nucleoside analogs.	Nucleosides	133-143	deoxycytidine kinase	Homo sapiens	80-100
2025274-2	1991	Cytoplasmic thymidine kinase (TK1), deoxycytidine kinase (dCK) and mitochondrial thymidine kinase (TK2) were completely purified from human leukemic spleen and their capacities to phosphorylate 43 nucleoside analogs were compared.	Nucleosides	197-207	thymidine kinase 2	Homo sapiens	99-102
1849471-3	1991	We describe here an alternative approach using the Epstein-Barr virus (EBV) encoded thymidine kinase (TK) to directly phosphorylate adducted nucleosides to give the [5"-32P]monophosphates.	Nucleosides	141-152	thymidine kinase	Human gammaherpesvirus 4	84-100
1849471-3	1991	We describe here an alternative approach using the Epstein-Barr virus (EBV) encoded thymidine kinase (TK) to directly phosphorylate adducted nucleosides to give the [5"-32P]monophosphates.	Nucleosides	141-152	thymidine kinase	Human gammaherpesvirus 4	102-104
2006182-9	1991	One hypothesis that explains the effect of methotrexate on adenosine release is that, by inhibition of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase, methotrexate induces the accumulation of AICAR, the nucleoside precursor of which (5-aminoimidazole-4-carboxamide ribonucleoside referred to hereafter as acadesine) has previously been shown to cause adenosine release from ischemic cardiac tissue.	Nucleosides	225-235	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	150-155
2209778-1	1990	5"-Nucleotidase, a prominent nucleoside-producing ectoenzyme of glial plasma membranes, was studied by enzyme cytochemistry in the superior cervical ganglion of the rat under normal conditions and after pre- and postganglionic axotomy.	Nucleosides	29-39	5' nucleotidase, ecto	Rattus norvegicus	0-15
1714001-2	1991	Such an increase in plasma adenosine levels might be of physiological importance since this nucleoside is a known inhibitor of renin release and could therefore participate in a negative feedback loop whereby angiotensin II could limit its own biosynthesis.	Nucleosides	92-102	angiotensinogen	Rattus norvegicus	209-223
1650669-8	1991	IFN-alpha 2 treatment of cells induced modifications of nucleoside (e.g., thymidine and TFT), but not nucleobase (e.g., ACV) uptake.	Nucleosides	56-66	interferon alpha 2	Homo sapiens	0-11
27463204-0	1991	2-Chlorodeoxyadenosine (2-CdA): A Potent Chemotherapeutic and Immunosuppressive Nucleoside.	Nucleosides	80-90	cytidine deaminase	Homo sapiens	26-29
1668697-6	1991	7-Deaza-2"-deoxyguanosine protected the DNA-fragment from hydrolysis by the restriction endodeoxyribonuclease Eco RI, Pst I, Bam HI, and Sma I if the nucleoside was located within the recognition site.	Nucleosides	150-160	serine peptidase inhibitor Kazal type 1	Homo sapiens	118-123
2272119-2	1990	The observed increase in membrane fluidity and the suppression of nucleoside transport were early events of the HUdR action followed by decrease of galactosylated glycan and HSPG expression.	Nucleosides	66-76	syndecan 2	Homo sapiens	174-178
1742765-5	1991	We therefore assessed the ability of this nucleoside to inhibit the positive inotropic effect of insulin, a hormone that exerts a positive inotropic effect independently of alterations in cyclic AMP.	Nucleosides	42-52	insulin	Canis lupus familiaris	97-104
2090926-2	1990	The enhancement of adenosine transport by inhibitors of adenosine deaminase (the enzyme which deaminates adenosine to inosine) and the ecto-localization of adenosine deaminase suggest a contribution of the enzyme in taking up nucleosides.	Nucleosides	226-237	adenosine deaminase	Homo sapiens	156-175
2207073-0	1990	Nucleoside inhibitors of rhodopsin kinase.	Nucleosides	0-10	G protein-coupled receptor kinase 7	Homo sapiens	25-41
2369634-3	1990	These studies and nuclear Overhauser effects support an unfolded or conformationally flexible structure for the antibiotic, and the syn and anti conformations of the nucleoside moiety were found to coexist.	Nucleosides	166-176	synemin	Homo sapiens	132-135
2200519-5	1990	The presence of guanosine or GMP at the active site of p21 leads to a marked stabilization of p21 against spontaneous denaturation when compared with the nucleotide- and nucleoside-free protein.	Nucleosides	170-180	H3 histone pseudogene 16	Homo sapiens	55-58
2200519-5	1990	The presence of guanosine or GMP at the active site of p21 leads to a marked stabilization of p21 against spontaneous denaturation when compared with the nucleotide- and nucleoside-free protein.	Nucleosides	170-180	H3 histone pseudogene 16	Homo sapiens	94-97
2195987-6	1990	The ITR highly overestimated the cytotoxicity of 5-fluoro-2"-deoxyuridine: the irreversible inhibition of thymidylate synthase by this nucleoside resulted in an ED50 value 100-fold lower than that observed with the clonogenic assay.	Nucleosides	135-145	thymidylate synthetase	Homo sapiens	106-126
2393279-2	1990	The mechanisms responsible for this synergistic activity are not known, but we hypothesize that IFN-alpha-induced alterations of nucleoside metabolism in virus-infected cells may play an important role.	Nucleosides	129-139	interferon alpha 1	Homo sapiens	96-105
2393279-7	1990	Although IFN-alpha affected the metabolism of natural nucleosides in HSV-1-infected cells, it did not significantly reduce the uptake of the antiviral guanosine analog acyclovir into HSV-1-infected cells or the amount of acyclovir-5"-triphosphate accumulated.	Nucleosides	54-65	interferon alpha 1	Homo sapiens	9-18
2393279-8	1990	Therefore, in IFN-alpha-treated cells the concentration of a natural nucleoside, thymidine, was reduced, as were the pools of all deoxyribonucleoside-5"-triphosphates.	Nucleosides	69-79	interferon alpha 1	Homo sapiens	14-23
2393279-10	1990	These data suggest that IFN-alpha-induced alterations in nucleoside metabolism may be one mechanism whereby IFN-alpha and acyclovir express synergistic antiherpes-virus activity.	Nucleosides	57-67	interferon alpha 1	Homo sapiens	24-33
2393279-10	1990	These data suggest that IFN-alpha-induced alterations in nucleoside metabolism may be one mechanism whereby IFN-alpha and acyclovir express synergistic antiherpes-virus activity.	Nucleosides	57-67	interferon alpha 1	Homo sapiens	108-117
2372377-1	1990	A combination of the gel retardation assay and interference by hydroxyl radical modification (missing nucleoside technique) was used to analyze the interaction of the glucocorticoid receptor (GR) with various glucocorticoid responsive elements (GRE).	Nucleosides	102-112	nuclear receptor subfamily 3 group C member 1	Homo sapiens	167-190
2372377-1	1990	A combination of the gel retardation assay and interference by hydroxyl radical modification (missing nucleoside technique) was used to analyze the interaction of the glucocorticoid receptor (GR) with various glucocorticoid responsive elements (GRE).	Nucleosides	102-112	nuclear receptor subfamily 3 group C member 1	Homo sapiens	192-194
1693058-3	1990	Antibody to interferon alpha/beta could completely abolish the protective activity of the nucleoside against virus infection in mice, whereas antibodies to interferons beta and gamma could not, indicating that interferon alpha was of major importance to confer protection to the animals.	Nucleosides	90-100	interferon alpha B	Mus musculus	12-33
2329126-9	1990	If the newborn brain can synthesize appropriate concentrations of adenosine, this nucleoside may play a major role in regional CBF regulation during the neonatal period.	Nucleosides	82-92	CCAAT enhancer binding protein zeta	Homo sapiens	127-130
2156693-1	1990	A theoretical model of the interactions occurring between nucleosides and the active site of adenosine deaminase.	Nucleosides	58-69	adenosine deaminase	Homo sapiens	93-112
1693058-3	1990	Antibody to interferon alpha/beta could completely abolish the protective activity of the nucleoside against virus infection in mice, whereas antibodies to interferons beta and gamma could not, indicating that interferon alpha was of major importance to confer protection to the animals.	Nucleosides	90-100	interferon alpha	Mus musculus	12-28
1967270-9	1990	Northern blot and in vitro translation analyses of poly(A+) RNA from c3Ado-treated HEC revealed that this nucleoside analog selectively decreased steady-state levels of ICAM-1 mRNA.	Nucleosides	106-116	intercellular adhesion molecule 1	Homo sapiens	169-175
2106487-4	1990	However, the addition of interferon alpha/beta in vitro significantly increased the magnitude of phagocyte activation by the nucleosides, suggesting an important role for cytokines/lymphokines in the nucleoside-induced phagocyte activation in vivo.	Nucleosides	125-136	interferon alpha	Mus musculus	25-41
2092960-8	1990	A10 may act as a nucleoside antagonist and interact very closely with adenosine units in nucleic acids and enzymes, which may interfere with protein synthesis in neoplastic cells.	Nucleosides	17-27	immunoglobulin kappa variable 6D-21 (non-functional)	Homo sapiens	0-3
2106487-4	1990	However, the addition of interferon alpha/beta in vitro significantly increased the magnitude of phagocyte activation by the nucleosides, suggesting an important role for cytokines/lymphokines in the nucleoside-induced phagocyte activation in vivo.	Nucleosides	125-135	interferon alpha	Mus musculus	25-41
34942489-1	2022	Human purine nucleoside phosphorylase (HsPNP) catalyzes reversible phosphorolysis of nucleosides and deoxynucleosides in the purine cascade.	Nucleosides	85-96	purine nucleoside phosphorylase	Homo sapiens	6-37
33771622-6	2021	Subcutaneously administered MSN-mRNA significantly enhanced in vivo translation and expression kinetics of naked mRNA in unmodified, nucleoside-modified, and HPLC purified formats.	Nucleosides	133-143	moesin	Mus musculus	28-31
33766591-2	2021	SARS-CoV-2 RNA dependent RNA polymerase (RdRp) which is almost preserved across different viral species can be a potential target for development of antiviral drugs, including nucleoside analogues (NA).	Nucleosides	176-186	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	41-45
32797897-7	2020	Sil-Glc-NCDs column can be used for separation of base, nucleosides and antibiotics etc.	Nucleosides	56-67	STIL centriolar assembly protein	Homo sapiens	0-3
10199570-7	1999	We show that exportin-t has a strong preference for tRNA with correctly processed 5" and 3" ends and nucleoside modification.	Nucleosides	101-111	exportin for tRNA	Homo sapiens	13-23
34974239-0	2022	BH+/MH+-matching method for discovery of cis-diol-containing modified nucleosides in urine by ribose-targeted solid phase extraction followed by dual-mass spectrometry platform identification.	Nucleosides	70-81	bleomycin hydrolase	Homo sapiens	0-2
34919400-1	2022	Despite its importance in the nucleoside (and nucleoside prodrug) metabolism, the structure of the active conformation of human thymidine kinase 1 (hTK1) remains elusive.	Nucleosides	30-40	thymidine kinase 1	Homo sapiens	128-146
34919400-1	2022	Despite its importance in the nucleoside (and nucleoside prodrug) metabolism, the structure of the active conformation of human thymidine kinase 1 (hTK1) remains elusive.	Nucleosides	30-40	thymidine kinase 1	Homo sapiens	148-152
34919400-1	2022	Despite its importance in the nucleoside (and nucleoside prodrug) metabolism, the structure of the active conformation of human thymidine kinase 1 (hTK1) remains elusive.	Nucleosides	46-56	thymidine kinase 1	Homo sapiens	128-146
34919400-1	2022	Despite its importance in the nucleoside (and nucleoside prodrug) metabolism, the structure of the active conformation of human thymidine kinase 1 (hTK1) remains elusive.	Nucleosides	46-56	thymidine kinase 1	Homo sapiens	148-152
34415015-2	2021	ABC transporters mediate the translocation of a diverse range of substrates across cellular membranes, including amino acids, nucleosides, lipids, sugars and xenobiotics.	Nucleosides	126-137	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	0-3
34873989-5	2021	A remarkable change was seen in orientation at the nucleoside base region of both the ligands, which are bound with OAS1 protein from Frieswal and Sahiwal cattle.	Nucleosides	51-61	2',5'-oligoadenylate synthetase 1	Bos taurus	116-120
34905656-0	2022	5"-Phosphorylation Increases the Efficacy of Nucleoside Inhibitors of the DNA Repair Enzyme SNM1A.	Nucleosides	45-55	DNA cross-link repair 1A	Homo sapiens	92-97
34905656-4	2022	Previous studies have demonstrated the feasibility of inhibiting SNM1A using modified nucleosides appended with zinc-binding groups.	Nucleosides	86-97	DNA cross-link repair 1A	Homo sapiens	65-70
34192523-6	2021	Collectively, the data further implicate NUDT15 as a broad-spectrum metabolic regulator of nucleoside analog therapeutics, such as thiopurines and GCV.	Nucleosides	91-101	nudix hydrolase 15	Homo sapiens	41-47
34906077-7	2021	The purified recombinant horse TK1 showed broad substrate specificity, phosphorylating pyrimidine deoxyribo- and ribonucleosides and, to some extent, purine deoxynucleosides, including anticancer and antiviral nucleoside analogues.	Nucleosides	210-220	thymidine kinase 1	Equus caballus	31-34
34850656-0	2021	Plant-Derived Natural Non-Nucleoside Analog Inhibitors (NNAIs) against RNA-Dependent RNA Polymerase Complex (nsp7/nsp8/nsp12) of SARS-CoV-2.	Nucleosides	26-36	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	109-113
34884945-5	2021	The GS3 plants accumulated nucleosides related to the nucleotide salvage pathway, beta-alanine, and serotonin.	Nucleosides	27-38	glutathione synthetase, chloroplastic	Triticum aestivum	4-7
34868394-1	2021	Objective: Ribonucleotide reductase M2 (RRM2) as an enzyme that catalyzes the deoxyreduction of nucleosides to deoxyribonucleoside triphosphate (dNTP) has been extensively studied, and it plays a crucial role in regulating cell proliferation.	Nucleosides	96-107	ribonucleotide reductase regulatory subunit M2	Rattus norvegicus	11-38
34868394-1	2021	Objective: Ribonucleotide reductase M2 (RRM2) as an enzyme that catalyzes the deoxyreduction of nucleosides to deoxyribonucleoside triphosphate (dNTP) has been extensively studied, and it plays a crucial role in regulating cell proliferation.	Nucleosides	96-107	ribonucleotide reductase regulatory subunit M2	Rattus norvegicus	40-44
34806007-2	2021	Combining the 3-deoxyribofuranose part of cordycepin with the modified purine ring of a nucleoside "hit" led to the discovery of 4-amino-5-(4-chlorophenyl)-N7-(3"-deoxy-beta-d-ribofuranosyl)-pyrrolo(2,3-d)pyrimidine (Cpd1), revealing promising anti-T. cruzi activity.	Nucleosides	88-98	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	Mus musculus	217-221
34613689-4	2021	Far from merely being cautionary tales about the conduct of scientific research, these errors have had significant practical impact, by hampering a correct understanding of RdRp structure and mechanism, its inhibition by nucleoside analogues such as remdesivir, and the discovery and characterization of such analogues.	Nucleosides	221-231	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	173-177
34697820-3	2021	CD39 catalyzes the extracellular hydrolysis of nucleoside tri- and diphosphates, mainly adenosine 5"-triphosphate (ATP) and ADP, yielding adenosine monophosphate, which is further hydrolyzed by ecto-5"-nucleotidase (CD73) to produce adenosine.	Nucleosides	47-57	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	0-4
34697820-3	2021	CD39 catalyzes the extracellular hydrolysis of nucleoside tri- and diphosphates, mainly adenosine 5"-triphosphate (ATP) and ADP, yielding adenosine monophosphate, which is further hydrolyzed by ecto-5"-nucleotidase (CD73) to produce adenosine.	Nucleosides	47-57	5'-nucleotidase ecto	Homo sapiens	194-214
34697820-3	2021	CD39 catalyzes the extracellular hydrolysis of nucleoside tri- and diphosphates, mainly adenosine 5"-triphosphate (ATP) and ADP, yielding adenosine monophosphate, which is further hydrolyzed by ecto-5"-nucleotidase (CD73) to produce adenosine.	Nucleosides	47-57	5'-nucleotidase ecto	Homo sapiens	216-220
34817199-0	2022	Nucleoside-modified mRNA vaccines protect IFNAR-/- mice against Crimean Congo hemorrhagic fever virus infection.	Nucleosides	0-10	interferon (alpha and beta) receptor 1	Mus musculus	42-47
34751688-8	2021	Our work provides a theoretical basis for the multistep elevator-like transportation mechanism of nucleosides, which helps to further understand the dynamic recognition between nucleoside substrates and hCNT3 as well as the design of nucleoside anticancer drugs.	Nucleosides	98-109	solute carrier family 28 member 3	Homo sapiens	203-208
34751688-8	2021	Our work provides a theoretical basis for the multistep elevator-like transportation mechanism of nucleosides, which helps to further understand the dynamic recognition between nucleoside substrates and hCNT3 as well as the design of nucleoside anticancer drugs.	Nucleosides	177-187	solute carrier family 28 member 3	Homo sapiens	203-208
34751688-8	2021	Our work provides a theoretical basis for the multistep elevator-like transportation mechanism of nucleosides, which helps to further understand the dynamic recognition between nucleoside substrates and hCNT3 as well as the design of nucleoside anticancer drugs.	Nucleosides	234-244	solute carrier family 28 member 3	Homo sapiens	203-208
34735132-5	2021	This system performed well using only approximately 107-108 particles of exosomes to obtain modified nucleoside levels between 0.001 and 0.03, and the most striking result was that the content of m6A in exosomal small RNAs was continuously higher than that in the cells being analyzed.	Nucleosides	101-111	glycoprotein M6A	Homo sapiens	196-199
34405443-6	2021	Using mice that express a thymidine kinase (tk) "suicide gene" driven by the 3.6Col1a1 promoter (Col1-tk), proliferating osteoblast lineage cells can be ablated upon exposure to the nucleoside analog ganciclovir (GCV).	Nucleosides	182-192	collagen, type I, alpha 1	Mus musculus	80-86
34850656-0	2021	Plant-Derived Natural Non-Nucleoside Analog Inhibitors (NNAIs) against RNA-Dependent RNA Polymerase Complex (nsp7/nsp8/nsp12) of SARS-CoV-2.	Nucleosides	26-36	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	114-118
34382915-3	2021	In the present study, we discovered that RNA-derived modified nucleosides are exported to extracellular space through equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2), with ENT1 showing higher preference for modified nucleosides than ENT2.	Nucleosides	62-73	nucleoside transporters 1 and 2	None	132-163
34382915-3	2021	In the present study, we discovered that RNA-derived modified nucleosides are exported to extracellular space through equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2), with ENT1 showing higher preference for modified nucleosides than ENT2.	Nucleosides	62-73	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	165-169
34382915-3	2021	In the present study, we discovered that RNA-derived modified nucleosides are exported to extracellular space through equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2), with ENT1 showing higher preference for modified nucleosides than ENT2.	Nucleosides	62-73	solute carrier family 29 member 2	Homo sapiens	174-178
34382915-3	2021	In the present study, we discovered that RNA-derived modified nucleosides are exported to extracellular space through equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2), with ENT1 showing higher preference for modified nucleosides than ENT2.	Nucleosides	62-73	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	186-190
34382915-3	2021	In the present study, we discovered that RNA-derived modified nucleosides are exported to extracellular space through equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2), with ENT1 showing higher preference for modified nucleosides than ENT2.	Nucleosides	62-73	solute carrier family 29 member 2	Homo sapiens	247-251
34382915-3	2021	In the present study, we discovered that RNA-derived modified nucleosides are exported to extracellular space through equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2), with ENT1 showing higher preference for modified nucleosides than ENT2.	Nucleosides	230-241	nucleoside transporters 1 and 2	None	132-163
34382915-3	2021	In the present study, we discovered that RNA-derived modified nucleosides are exported to extracellular space through equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2), with ENT1 showing higher preference for modified nucleosides than ENT2.	Nucleosides	230-241	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	165-169
34382915-3	2021	In the present study, we discovered that RNA-derived modified nucleosides are exported to extracellular space through equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2), with ENT1 showing higher preference for modified nucleosides than ENT2.	Nucleosides	230-241	solute carrier family 29 member 2	Homo sapiens	174-178
34382915-3	2021	In the present study, we discovered that RNA-derived modified nucleosides are exported to extracellular space through equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2), with ENT1 showing higher preference for modified nucleosides than ENT2.	Nucleosides	230-241	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	186-190
34382915-4	2021	Pharmacological inhibition or genetic deletion of ENT1 and ENT2 significantly attenuated export of modified nucleosides thereby resulting in their accumulation in cytosol.	Nucleosides	108-119	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	50-54
34382915-4	2021	Pharmacological inhibition or genetic deletion of ENT1 and ENT2 significantly attenuated export of modified nucleosides thereby resulting in their accumulation in cytosol.	Nucleosides	108-119	solute carrier family 29 member 2	Homo sapiens	59-63
34382915-5	2021	Using mutagenesis strategy, we identified an amino acid residue in ENT1 that is involved in the discrimination of unmodified and modified nucleosides.	Nucleosides	138-149	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	67-71
34600563-10	2021	CSUR networking and dissemination facilitated development of a collaborative care network for TK2d disease, wherein participants share information and protocols to request approval from the Ministry of Health to initiate nucleoside therapy.	Nucleosides	221-231	thymidine kinase 2	Homo sapiens	94-97
34641952-1	2021	BACKGROUND: SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms.	Nucleosides	54-64	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	12-18
34641952-2	2021	Hence, SAMHD1 inhibitors are promising candidates for the sensitisation of leukaemia cells to nucleoside analogue-based therapy.	Nucleosides	94-104	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	7-13
34641952-14	2021	In 24 CNDAC-adapted acute myeloid leukaemia (AML) sublines, resistance was driven by DCK (catalyses initial nucleoside phosphorylation) loss.	Nucleosides	108-118	deoxycytidine kinase	Homo sapiens	85-88
34517419-2	2021	Remdesivir, the broad-spectrum RdRp inhibitor acts as nucleoside-analogues (NAs).	Nucleosides	54-64	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	31-35
34448542-2	2021	In this article, we identified a natural nucleoside analogue, cordycepin, that has the ability to significantly improve lysosomal function, enhance the activity of the lysosomal representative protease cathepsin B (CTSB), and promote the expression of the functional protein lysosomal-associated membrane protein 2 (LAMP2) on the lysosomal membrane.	Nucleosides	41-51	cathepsin B	Homo sapiens	202-213
34448542-2	2021	In this article, we identified a natural nucleoside analogue, cordycepin, that has the ability to significantly improve lysosomal function, enhance the activity of the lysosomal representative protease cathepsin B (CTSB), and promote the expression of the functional protein lysosomal-associated membrane protein 2 (LAMP2) on the lysosomal membrane.	Nucleosides	41-51	cathepsin B	Homo sapiens	215-219
34448542-2	2021	In this article, we identified a natural nucleoside analogue, cordycepin, that has the ability to significantly improve lysosomal function, enhance the activity of the lysosomal representative protease cathepsin B (CTSB), and promote the expression of the functional protein lysosomal-associated membrane protein 2 (LAMP2) on the lysosomal membrane.	Nucleosides	41-51	lysosomal associated membrane protein 2	Homo sapiens	275-314
34448542-2	2021	In this article, we identified a natural nucleoside analogue, cordycepin, that has the ability to significantly improve lysosomal function, enhance the activity of the lysosomal representative protease cathepsin B (CTSB), and promote the expression of the functional protein lysosomal-associated membrane protein 2 (LAMP2) on the lysosomal membrane.	Nucleosides	41-51	lysosomal associated membrane protein 2	Homo sapiens	316-321
34498979-6	2021	Treated mice showed a consistent long-term (1 year) reduction in plasma nucleoside (thymidine and deoxyuridine) levels that correlated with the presence of TYMP mRNA and functional enzyme in liver cells.	Nucleosides	72-82	thymidine phosphorylase	Mus musculus	156-160
34381204-0	2021	Addendum: Cryptic phosphorylation in nucleoside natural product biosynthesis.	Nucleosides	37-47	cripto, FRL-1, cryptic family 1	Homo sapiens	10-17
34611429-1	2021	Background: The thresholds of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (PIVKA-II) when detecting hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients with antiviral nucleoside analog (NA) remain controversial.	Nucleosides	198-208	alpha fetoprotein	Homo sapiens	30-47
34790902-3	2021	These nucleoside analogs are incorporated into replicating DNA where they inhibit DNA cytosine methyltransferases DNMT1, DNMT3A and DNMT3B through irreversible covalent interactions.	Nucleosides	6-16	DNA methyltransferase (cytosine-5) 1	Mus musculus	114-119
34790902-3	2021	These nucleoside analogs are incorporated into replicating DNA where they inhibit DNA cytosine methyltransferases DNMT1, DNMT3A and DNMT3B through irreversible covalent interactions.	Nucleosides	6-16	DNA methyltransferase 3A	Mus musculus	121-127
34790902-3	2021	These nucleoside analogs are incorporated into replicating DNA where they inhibit DNA cytosine methyltransferases DNMT1, DNMT3A and DNMT3B through irreversible covalent interactions.	Nucleosides	6-16	DNA methyltransferase 3B	Mus musculus	132-138
34611429-1	2021	Background: The thresholds of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (PIVKA-II) when detecting hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients with antiviral nucleoside analog (NA) remain controversial.	Nucleosides	198-208	alpha fetoprotein	Homo sapiens	49-52
34303192-5	2021	Here, we screened non-nucleoside antivirals and found three out of them to be strongest in binding to RdRp out of which two retained binding even using molecular dynamic simulations.	Nucleosides	22-32	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	102-106
34482229-4	2021	Herein, the synthesis of a family of squaramide- and thiosquaramide-bearing nucleoside derivatives and their evaluation as SNM1A inhibitors is reported.	Nucleosides	76-86	DNA cross-link repair 1A	Homo sapiens	123-128
34576219-0	2021	Discovery of a Non-Nucleoside SETD2 Methyltransferase Inhibitor against Acute Myeloid Leukemia.	Nucleosides	19-29	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	30-35
34482229-5	2021	A gel electrophoresis assay was used to identify nucleoside derivatives bearing an N-hydroxysquaramide or squaric acid moiety at the 3"-position, and a thymidine derivative bearing a 5"-thiosquaramide, as candidate SNM1A inhibitors.	Nucleosides	49-59	DNA cross-link repair 1A	Homo sapiens	215-220
34435786-2	2021	We synthesized truncated nucleoside derivatives and discovered 6c (Ki = 2.40 nM) as a potent human A3 adenosine receptor (hA3AR) agonist, and subtle chemical modification induced a shift from antagonist to agonist.	Nucleosides	25-35	adenosine A3 receptor	Homo sapiens	122-127
34275128-1	2021	BACKGROUND AND OBJECTIVES: Equilibrative nucleoside transporter (ENT) 1 is a widely-expressed drug transporter, handling nucleoside analogues as well as endogenous nucleosides.	Nucleosides	121-131	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	27-71
34480004-5	2021	TYMP catalyzes the first step in the catabolism of thymidine, which competitively inhibits intratumoral accumulation of the nucleoside analog PET probe 3"-deoxy-3"-(18F)fluorothymidine ((18F)FLT).	Nucleosides	124-134	thymidine phosphorylase	Homo sapiens	0-4
34275128-1	2021	BACKGROUND AND OBJECTIVES: Equilibrative nucleoside transporter (ENT) 1 is a widely-expressed drug transporter, handling nucleoside analogues as well as endogenous nucleosides.	Nucleosides	164-175	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	27-71
34275128-11	2021	This point likely merits attention in terms of possible drug-drug interactions, notably for nucleoside analogues, whose ENT1-mediated uptake into their target cells may be hampered by co-administrated TKIs such as lorlatinib.	Nucleosides	92-102	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	120-124
34258331-1	2021	Equilibrative nucleoside transporter 1 (ENT1) transfers nucleosides, such as adenosine, across plasma membranes.	Nucleosides	56-67	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	40-44
34462431-8	2021	This uridine-dependent resistance to DHODH inhibitors can be abrogated by dipyridamole, an FDA-approved drug that blocks nucleoside transport.	Nucleosides	121-131	dihydroorotate dehydrogenase (quinone)	Homo sapiens	37-42
34462431-10	2021	These findings suggest that a combination of targeting DHODH and nucleoside transport is a promising strategy to overcome intrinsic resistance to DHODH-based cancer therapeutics.	Nucleosides	65-75	dihydroorotate dehydrogenase (quinone)	Homo sapiens	146-151
34354677-4	2021	Nucleoside analogs are the most promising RdRp inhibitors and have shown effectiveness in vitro, as well as in clinical settings.	Nucleosides	0-10	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	42-46
34354677-5	2021	One limitation of such RdRp inhibitors is the removal of incorporated nucleoside analogs by SARS-CoV-2 exonuclease (ExoN).	Nucleosides	70-80	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	23-27
34143495-7	2021	Relaxin-2 significantly modified the hepatic levels of 19 glycerophospholipids, 2 saturated (SFA) and 1 monounsaturated (MUFA) fatty acids (FA), 3 diglycerides, 1 sphingomyelin, 2 aminoacids, 5 nucleosides, 2 nucleotides, 1 carboxylic acid, 1 redox electron carrier, and 1 vitamin.	Nucleosides	194-205	relaxin 2	Homo sapiens	0-9
34258331-1	2021	Equilibrative nucleoside transporter 1 (ENT1) transfers nucleosides, such as adenosine, across plasma membranes.	Nucleosides	56-67	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	0-38
34103491-0	2021	Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema.	Nucleosides	0-10	vascular endothelial growth factor C	Mus musculus	20-25
34103491-3	2021	Here, we utilized nucleoside-modified mRNA encapsulated in lipid nanoparticles (LNPs) encoding murine Vascular Endothelial Growth Factor C (VEGFC) to stimulate lymphatic growth and function and reduce experimental lymphedema in mouse models.	Nucleosides	18-28	vascular endothelial growth factor C	Mus musculus	102-138
34103491-3	2021	Here, we utilized nucleoside-modified mRNA encapsulated in lipid nanoparticles (LNPs) encoding murine Vascular Endothelial Growth Factor C (VEGFC) to stimulate lymphatic growth and function and reduce experimental lymphedema in mouse models.	Nucleosides	18-28	vascular endothelial growth factor C	Mus musculus	140-145
35395178-6	2022	Our work represents a substantial step in generating potent, selective, and non-nucleoside inhibitors of DNMT1.	Nucleosides	80-90	DNA methyltransferase 1	Homo sapiens	105-110
35306047-3	2022	We have previously found that mutations in DNMT3A, one of the most commonly mutated genes in acute myeloid leukemia and associated with poor prognosis, predisposed cells to DNA damage and cell killing by cytarabine, cladribine, and other nucleoside analogs, which coincided with PARP1 dysfunction and DNA repair defect (Venugopal et al, 2021).	Nucleosides	238-248	DNA methyltransferase 3 alpha	Homo sapiens	43-49
35306047-3	2022	We have previously found that mutations in DNMT3A, one of the most commonly mutated genes in acute myeloid leukemia and associated with poor prognosis, predisposed cells to DNA damage and cell killing by cytarabine, cladribine, and other nucleoside analogs, which coincided with PARP1 dysfunction and DNA repair defect (Venugopal et al, 2021).	Nucleosides	238-248	poly(ADP-ribose) polymerase 1	Homo sapiens	279-284
35193822-1	2022	Thymidine phosphorylase (TP) catalyzes the reversible phosphorolysis of thymidine, maintaining nucleoside homeostasis for DNA repair and replication.	Nucleosides	95-105	thymidine phosphorylase	Homo sapiens	0-23
35193822-1	2022	Thymidine phosphorylase (TP) catalyzes the reversible phosphorolysis of thymidine, maintaining nucleoside homeostasis for DNA repair and replication.	Nucleosides	95-105	thymidine phosphorylase	Homo sapiens	25-27
34531748-4	2021	5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is a cell permeable nucleoside with pleiotropic effects on anti-inflammatory and antioxidant stress that binds with adenosine monophosphate protein kinase (AMPK) and induces AMPK activation.	Nucleosides	74-84	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	170-208
34531748-4	2021	5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is a cell permeable nucleoside with pleiotropic effects on anti-inflammatory and antioxidant stress that binds with adenosine monophosphate protein kinase (AMPK) and induces AMPK activation.	Nucleosides	74-84	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	210-214
34531748-4	2021	5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is a cell permeable nucleoside with pleiotropic effects on anti-inflammatory and antioxidant stress that binds with adenosine monophosphate protein kinase (AMPK) and induces AMPK activation.	Nucleosides	74-84	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	228-232
34455933-4	2021	A unique collection of nucleoside analogs was screened against the SARS-CoV-2 helicase protein, for which a molecular docking experiment was executed to depict the selected ligand"s binding affinity with the SARS-CoV-2 helicase proteins.	Nucleosides	23-33	helicase for meiosis 1	Homo sapiens	78-86
34455933-4	2021	A unique collection of nucleoside analogs was screened against the SARS-CoV-2 helicase protein, for which a molecular docking experiment was executed to depict the selected ligand"s binding affinity with the SARS-CoV-2 helicase proteins.	Nucleosides	23-33	helicase for meiosis 1	Homo sapiens	219-227
34102301-8	2021	Besides, the production of IL-6 in LPS/IFN-gamma induced THP-1 cells was also decreased by both nucleosides.	Nucleosides	96-107	interleukin 6	Homo sapiens	27-31
34102301-8	2021	Besides, the production of IL-6 in LPS/IFN-gamma induced THP-1 cells was also decreased by both nucleosides.	Nucleosides	96-107	interferon gamma	Homo sapiens	39-48
34128837-2	2021	We now show that ENT2, a transporter that regulates nucleoside flux at the BBB, may offer an unexpected path to circumventing this barrier to allow targeting of brain tumors with an anti-DNA autoantibody.	Nucleosides	52-62	solute carrier family 29 member 2	Homo sapiens	17-21
34276356-4	2021	Methods: Remdesivir and its active nucleoside metabolite GS-441524 were used to treat TGF-beta stimulated renal fibroblasts (NRK-49F) and human renal epithelial (HK2) cells.	Nucleosides	35-45	transforming growth factor alpha	Homo sapiens	86-94
34085252-0	2021	Quantification of Modified Nucleosides in the Context of NAIL-MS.	Nucleosides	27-38	CD244 molecule	Homo sapiens	57-61
35473877-6	2022	The as-prepared adsorbent coupled with high performance liquid chromatography was used for analysis of four nucleosides including cytidine, uridine, guanosine, and adenosine in urine sample with the detection limits in range of 0.002-0.005 mug mL-1 and the quantitative limits in range of 0.008-0.018 mug mL-1.	Nucleosides	108-119	L1 cell adhesion molecule	Mus musculus	244-248
35473877-6	2022	The as-prepared adsorbent coupled with high performance liquid chromatography was used for analysis of four nucleosides including cytidine, uridine, guanosine, and adenosine in urine sample with the detection limits in range of 0.002-0.005 mug mL-1 and the quantitative limits in range of 0.008-0.018 mug mL-1.	Nucleosides	108-119	L1 cell adhesion molecule	Mus musculus	305-309
35486677-5	2022	In contrast to cancer cells, where succinate dehydrogenase (SDH)/complex II inactivation drives cell transformation and growth, SDH/complex II deficiency in T cells caused proliferation and survival defects when the TCA cycle was truncated, blocking carbon flux to support nucleoside biosynthesis.	Nucleosides	273-283	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	60-63
35486677-6	2022	Replenishing the intracellular nucleoside pool partially relieved the dependence of T cells on SDH/complex II for proliferation and survival.	Nucleosides	31-41	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	95-98
35333330-3	2022	Unlike FTO, ALKBH5 efficiently catalyzes fragmentation of its proposed nascent hemiaminal intermediate to give formaldehyde and a demethylated nucleoside.	Nucleosides	143-153	alkB homolog 5, RNA demethylase	Homo sapiens	12-18
35439003-7	2022	Born-Oppenheimer molecular dynamics trajectory calculations of the dinucleotides and nucleoside pairs indicated rapid exothermic proton transfer from noncanonical T+  to A in both dAT+  and dA dT+ , leading to charge and radical separation.	Nucleosides	85-95	Dopamine transporter	Drosophila melanogaster	180-183
35411000-0	2022	CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma.	Nucleosides	68-78	carnitine palmitoyltransferase 1A	Rattus norvegicus	0-5
35411000-9	2022	Periodic activation of CPT1A increases the content of nucleoside metabolic intermediates promoting cell cycle progression in NPC cells.	Nucleosides	54-64	carnitine palmitoyltransferase 1a, liver	Mus musculus	23-28
35458631-0	2022	In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions.	Nucleosides	128-139	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	40-71
35458631-0	2022	In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions.	Nucleosides	128-139	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	73-77
35458631-1	2022	Inhibition of human DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) by different chiral lipophilic nucleoside derivatives was studied.	Nucleosides	108-118	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	71-75
35458631-3	2022	It was shown that D-lipophilic nucleoside derivatives manifested higher inhibition activity than their L-analogs, and configuration of the carbohydrate moiety can influence the mechanism of Tdp1 inhibition.	Nucleosides	31-41	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	190-194
35152062-1	2022	Various adenosine receptor nucleoside-like ligands were found to modulate ATP hydrolysis by the multidrug transporter ABCG2.	Nucleosides	27-37	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	118-123
35278429-6	2022	Here, we report the successful synthesis of a series of miR-30c analogs by using different chemically modified nucleosides.	Nucleosides	111-122	microRNA 30c-1	Homo sapiens	56-63
35119848-2	2022	Single-nucleoside polymorphisms of the human gene for the enzyme, Cdkal1 that post-transcriptionally modifies t6A37 to ms2t6A37 in tRNAUUULys3, correlate with type 2 diabetes mellitus.	Nucleosides	7-17	CDK5 regulatory subunit associated protein 1 like 1	Homo sapiens	66-72
35257725-0	2022	In vitro and in vivo efficacy of a novel nucleoside analog H44 against Crimean-Congo hemorrhagic fever virus.	Nucleosides	41-51	histocompatibility 44	Mus musculus	59-62
35085896-4	2022	Nucleosides and nucleobases could be effectively determined in hydrophilic interaction chromatography mode, and the separation performance of the Sil-Ur-DD was found to be even superior to that of the commercial XAmide column.	Nucleosides	0-11	STIL centriolar assembly protein	Homo sapiens	146-149
35222844-6	2022	Remarkably, the nucleoside antibiotic tunicamycin, which targets UDP-N-acetylglucosamine:dolichyl-phosphate N-acetylglucosaminephosphotransferase (ALG7) and N-glycosylation in other organisms, induces a delayed-death effect and inhibits parasite growth during the second IDC after treatment.	Nucleosides	16-26	dolichyl-phosphate N-acetylglucosaminephosphotransferase 1	Homo sapiens	147-151
2554903-3	1989	The decreased guanylate pools may explain the 30% reduction in cyclic GMP levels and GTPase activity measured after the treatment with the nucleosides.	Nucleosides	139-150	5'-nucleotidase, cytosolic II	Mus musculus	70-73
2553165-7	1989	The size and distribution of the 27.2 antigen on T cell subsets suggested that it might be the enzyme ecto-5" nucleotidase (NT), a phosphatidylinositol-linked enzyme that catalyzes dephosphorylation of monophosphate nucleotides to their respective nucleosides.	Nucleosides	248-259	5'-nucleotidase ecto	Homo sapiens	102-122
35221865-13	2022	Nucleoside transporters, such as ENT1, are vital in the uptake of synthetic nucleoside analogue drugs, used in cancer and viral chemotherapy.	Nucleosides	76-86	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	33-37
2549034-2	1989	Deoxycytidine kinase (dC kinase) is the rate-limiting enzyme in the anabolism of important anticancer and retroviral nucleoside derivatives.	Nucleosides	117-127	deoxycytidine kinase	Homo sapiens	0-20
2788493-0	1989	Mechanism of adenosine triphosphate catabolism induced by deoxyadenosine and by nucleoside analogues in adenosine deaminase-inhibited human erythrocytes.	Nucleosides	80-90	adenosine deaminase	Homo sapiens	104-123
2968343-11	1988	The data indicate that a peptide sequence of fragment A2 is involved in the binding of the nucleoside moiety of UTP and possibly belongs to the nucleotide domain of the ATPase in addition to the sequence of fragment A1 which contains the phosphorylation residue.	Nucleosides	91-101	dynein axonemal heavy chain 8	Homo sapiens	169-175
2562807-7	1989	Preincubation with cyclic AMP followed by insulin had an additive effect on nucleoside incorporation [160 +/- 4% (n = 3) above basal].	Nucleosides	76-86	insulin	Homo sapiens	42-49
2849455-2	1988	The nucleoside allopurinol riboside-3-thiocarboxamide (APR-TC; 4-(5H)oxo-1-beta-D-ribofuranosylpyrazolo[3,4,d]pyrimidine-3-thioca rboxamide) demonstrates potent in vitro antiviral activity against various DNA and RNA viruses and cytostatic activity against a variety of cell lines in culture.	Nucleosides	4-14	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	55-58
2466014-1	1988	The antitumor activity of 5-aza-2"-deoxycytidine (5-aza-dCyd), a nucleoside analog, was established in human head and neck cancer xenografts, transplanted in nude mice.	Nucleosides	65-75	Cyd	Drosophila melanogaster	56-60
3141901-2	1988	The snRNP particles in active splicing extracts are selectively bound to the immunoaffinity matrix, and are then gently eluted by competition with an excess of free nucleoside.	Nucleosides	165-175	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	4-9
3261757-2	1988	In the presence of coformycin, an adenosine deaminase inhibitor, or formycin B, a purine nucleoside phosphorylase inhibitor, DNA cleavage was induced by these nucleosides at concentrations of less than 50 microM.	Nucleosides	159-170	purine nucleoside phosphorylase	Homo sapiens	82-113
2851322-8	1988	Several dG nucleosides in the CAP site appear to be altered from the conventional C2"-endo/anti conformation.	Nucleosides	11-22	catabolite gene activator protein	Escherichia coli	30-33
2840503-9	1988	These new nucleosides were studied in comparison with the corresponding 2"-deoxy-erythro-pentofuranosyl derivatives, for their inhibitory activity against cellular thymidylate synthase (TS) and [3H]TdR incorporation into DNA, cytotoxicity against HL-60 cells, and antiviral activity against herpes simplex types 1 and 2 (HSV-1 and -2).	Nucleosides	10-21	thymidylate synthetase	Homo sapiens	164-184
2498637-6	1989	A number of nucleosides and nucleotides were synthesized and used to define structural requirements for P site-mediated inhibition of a detergent-solubilized adenylate cyclase from rat brain.	Nucleosides	12-23	dacapo	Drosophila melanogaster	0-1
2498637-6	1989	A number of nucleosides and nucleotides were synthesized and used to define structural requirements for P site-mediated inhibition of a detergent-solubilized adenylate cyclase from rat brain.	Nucleosides	12-23	dacapo	Drosophila melanogaster	24-25
2751707-3	1989	Relative efficiency of the mono- and dinucleotide donors depends on the 5"-terminal nucleoside moiety of the dinucleotide: upon ligation with the minimal phosphate acceptor GpUpC, dinucleotides pApA, pApC, and pApU are more effective than nucleotide diphosphate pAp; pGpC is more effective than pGp; efficiencies of pCpC and pCp are almost identical, and efficiency of pUpU is slightly lower than that of pUp.	Nucleosides	84-94	pappalysin 1	Homo sapiens	194-198
2751707-3	1989	Relative efficiency of the mono- and dinucleotide donors depends on the 5"-terminal nucleoside moiety of the dinucleotide: upon ligation with the minimal phosphate acceptor GpUpC, dinucleotides pApA, pApC, and pApU are more effective than nucleotide diphosphate pAp; pGpC is more effective than pGp; efficiencies of pCpC and pCp are almost identical, and efficiency of pUpU is slightly lower than that of pUp.	Nucleosides	84-94	protocadherin 8	Homo sapiens	200-204
2751707-3	1989	Relative efficiency of the mono- and dinucleotide donors depends on the 5"-terminal nucleoside moiety of the dinucleotide: upon ligation with the minimal phosphate acceptor GpUpC, dinucleotides pApA, pApC, and pApU are more effective than nucleotide diphosphate pAp; pGpC is more effective than pGp; efficiencies of pCpC and pCp are almost identical, and efficiency of pUpU is slightly lower than that of pUp.	Nucleosides	84-94	phosphoglycolate phosphatase	Homo sapiens	267-270
2558538-0	1989	Mechanism of ATP catabolism induced by deoxyadenosine and other nucleosides in adenosine deaminase-inhibited human erythrocytes.	Nucleosides	64-75	adenosine deaminase	Homo sapiens	79-98
2560324-4	1989	beta-ARPP is a substrate, albeit poor, for adenosine deaminase and solutions of the beta-anomer of this nucleoside and its monophosphate anomerize over time to give alpha- and beta-mixtures.	Nucleosides	104-114	ankyrin repeat domain 2	Homo sapiens	5-9
2560324-4	1989	beta-ARPP is a substrate, albeit poor, for adenosine deaminase and solutions of the beta-anomer of this nucleoside and its monophosphate anomerize over time to give alpha- and beta-mixtures.	Nucleosides	104-114	adenosine deaminase	Homo sapiens	43-62
2838807-0	1988	Synthesis of decadeoxyribonucleotides containing 5-modified uracils and their interactions with restriction endonucleases Bgl II, Sau 3AI and Mbo I (nucleosides and nucleotides 82).	Nucleosides	149-160	LPS responsive beige-like anchor protein	Homo sapiens	122-125
2836001-3	1988	These nucleoside analogues can also inhibit, by chain-terminating additions, the primitive lymphoid DNA polymerase, terminal deoxynucleotidyl transferase (TdT).	Nucleosides	6-16	DNA nucleotidylexotransferase	Homo sapiens	116-153
2836001-3	1988	These nucleoside analogues can also inhibit, by chain-terminating additions, the primitive lymphoid DNA polymerase, terminal deoxynucleotidyl transferase (TdT).	Nucleosides	6-16	DNA nucleotidylexotransferase	Homo sapiens	155-158
3355597-7	1988	Adenosine kinase apparently was not solely responsible for the phosphorylation of the nucleosides because a cell line that lacked this enzyme converted 3-deazaadenosine to phosphates.	Nucleosides	86-97	adenosine kinase	Mus musculus	0-16
2454388-7	1988	When neplanocin A and adenosine were incubated in cell lysates, rapid conversion to neplanocin D and inosine, respectively, were observed, illustrating the affinity of these nucleosides for cellular adenosine deaminase.	Nucleosides	174-185	adenosine deaminase	Mus musculus	199-218
3375071-2	1988	Condensation on a tetradecanucleotide template of hexa(penta)- and undecanucleotides differing only in the terminal nucleoside residue have been performed using water-soluble carbodiimide as a condensing agent.	Nucleosides	116-126	hexosaminidase subunit alpha	Homo sapiens	50-54
3802103-4	1987	The DNA from FUra-treated S-49 cells was purified by cesium chloride gradient centrifugation and degraded to nucleosides by DNase I and Crotalus atrox snake venom.	Nucleosides	109-120	deoxyribonuclease I	Mus musculus	124-131
2822457-6	1987	PyrNase and dNase may be complementary systems that serve physiologically to clear the cytosol of RNA and DNA degradation products during maturation of erythroid elements by conversion of nucleotide monophosphates to diffusible nucleosides.	Nucleosides	228-239	Deoxyribonuclease II	Drosophila melanogaster	12-17
3119605-2	1987	This nucleoside is cleaved by methylthioadenosine phosphorylase (MTA Pase) to adenine and 5-methylthioribose-I-phosphate in mammalian cells.	Nucleosides	5-15	methylthioadenosine phosphorylase	Homo sapiens	30-63
3119605-2	1987	This nucleoside is cleaved by methylthioadenosine phosphorylase (MTA Pase) to adenine and 5-methylthioribose-I-phosphate in mammalian cells.	Nucleosides	5-15	methylthioadenosine phosphorylase	Homo sapiens	65-73
2442198-2	1987	The activation of ADPRP is important for DNA repair and replication, and also has been postulated to play a role in the pathogenesis of lymphocyte dysfunction associated with chronic inflammatory diseases, and inborn errors of nucleoside metabolism.	Nucleosides	227-237	poly(ADP-ribose) polymerase 1	Homo sapiens	18-23
3607288-1	1987	We examined the ability of high concentrations of the naturally occurring nucleoside deoxycytidine (dCyd) to reverse the cytotoxicity of high (eg, greater than or equal to 10(-5) mol/L) concentrations of 1-B-D arabinofuranosylcytosine (Ara-C) toward normal (CFU-GM) and leukemic myeloid progenitor cells (L-CFU).	Nucleosides	74-84	Cyd	Drosophila melanogaster	100-104
3297306-2	1987	The enzymatic sites at which AD and other nucleoside analogues exert their cytotoxic effects have been postulated to include protein carboxylmethyltransferase (PCM), AdoHcy hydrolase, and ribonucleotide reductase.	Nucleosides	42-52	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	Mus musculus	125-158
3582674-0	1987	Role of nucleoside components and internucleotide phosphate groups of oligodeoxyribonucleotide template in its binding to human DNA polymerase alpha.	Nucleosides	8-18	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	128-148
3437464-7	1987	Experiments of [3H]thymidine autoradiography combined with immunofluorescence showed that a greater proportion of the LB1+ cells incorporated the radioactive nucleoside into their nuclei as compared to the 04+ cells.	Nucleosides	158-168	cytoskeleton associated protein 2	Homo sapiens	118-121
3030122-7	1987	We obtained cells (designated LLC-PK1-FBPase+) that express FBPase activity and are capable of growing in the complete absence of sugars or nucleosides.	Nucleosides	140-151	fructose-bisphosphatase 1	Sus scrofa	38-44
3494190-0	1987	Residual nitrobenzylthioinosine-resistant nucleoside transport in a transport mutant (AE1) of S49 murine T-lymphoma cells.	Nucleosides	42-52	solute carrier family 4 (anion exchanger), member 1	Mus musculus	86-89
3494190-2	1987	Residual nucleoside entry into AE1 cells occurred via two routes, nonmediated permeation and saturable, non-concentrative transport with broad substrate specificity and a Michaelis-Menten constant approximating that for thymidine transport in wild-type cells.	Nucleosides	9-19	solute carrier family 4 (anion exchanger), member 1	Mus musculus	31-34
3494190-3	1987	However, in contrast to nucleoside transport in wild-type cells, residual nucleoside transport in AE1 cells was resistant to inhibition by nitrobenzylthioinosine.	Nucleosides	74-84	solute carrier family 4 (anion exchanger), member 1	Mus musculus	98-101
3697153-2	1987	The substrate properties of these nucleosides, which are in the fixed syn conformation, have been examined in the uridine phosphorylase system.	Nucleosides	34-45	synemin	Homo sapiens	70-73
3115933-5	1987	Moreover, the nucleoside transport capacity, estimated from the binding of the radiolabeled nucleoside analogue, [3H]nitrobenzylthioinosine, showed a good correlation with ara-CTP accumulation.	Nucleosides	14-24	solute carrier family 25 member 1	Homo sapiens	176-179
3115933-5	1987	Moreover, the nucleoside transport capacity, estimated from the binding of the radiolabeled nucleoside analogue, [3H]nitrobenzylthioinosine, showed a good correlation with ara-CTP accumulation.	Nucleosides	92-102	solute carrier family 25 member 1	Homo sapiens	176-179
3115933-7	1987	We conclude that the cellular nucleoside transport capacity is the most important factor for the formation and accumulation of ara-CTP in the cells.	Nucleosides	30-40	solute carrier family 25 member 1	Homo sapiens	131-134
3783592-2	1986	This isomerization is characterized by a change in spectral properties and by a greater than 10-fold decrease in potency for those nucleosides that act as potent inhibitors of cytidine deaminase in their ribofuranose form.	Nucleosides	131-142	cytidine deaminase	Homo sapiens	176-194
3771789-6	1986	A myeloma protein that reacted with poly(G), poly(I), or poly(dT) also bound to the corresponding nucleosides or nucleotides conjugated to bovine serum albumin.	Nucleosides	98-109	albumin	Homo sapiens	146-159
3093064-1	1986	5"-Methylthioadenosine (MTA) is a naturally occurring nucleoside which is degraded by MTA phosphorylase (MTAase) to adenine and methylthioribose-1-phosphate in all normal mammalian cells.	Nucleosides	54-64	methylthioadenosine phosphorylase	Homo sapiens	86-103
3718228-6	1986	Similarly, Cd2+ inhibits the uptake of [2-14C]-thymidine and its incorporation into foetal DNA, whereas Hg2+ reduces the placental and foetal uptake, but has little or no effect on the utilization of the nucleoside.	Nucleosides	204-214	Cd2 molecule	Rattus norvegicus	11-14
3740298-5	1986	Isoproterenol alone elevated the release of adenosine into coronary effluents of isoproterenol-stimulated hearts, and adenosine deaminase prevented the release of the nucleoside.	Nucleosides	167-177	adenosine deaminase	Rattus norvegicus	118-137
3707127-9	1986	Results support the existence of several RNase A regions with affinity for purine nucleosides.	Nucleosides	82-93	ribonuclease pancreatic	Bos taurus	41-48
3000575-10	1986	The monophosphate donor specificity, divalent metal, high salt requirement, and nucleoside acceptor specificity of this enzyme activity paralleled that of a 5"-nucleotidase (EC 3.1.3.5) which catalyzes inosine phosphorylation.	Nucleosides	80-90	5'-nucleotidase ecto	Homo sapiens	157-172
3484740-5	1986	The addition of submicromolar concentrations of either p-nitrobenzylthioinosine or dipyridamole, two potent inhibitors of nucleoside transport, to wild type cells mimicked the phenotype of the AE1 cells with respect to hypoxanthine.	Nucleosides	122-132	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	193-196
3020902-0	1986	Regulation of deoxyadenosine and nucleoside analog phosphorylation by human placental adenosine kinase.	Nucleosides	33-43	adenosine kinase	Homo sapiens	86-102
3020902-7	1986	The high Km values for phosphorylation of dadenosine and adenine arabinoside suggest that adenosine kinase may be less likely to phosphorylate these nucleosides in vivo than other enzymes with lower Km values.	Nucleosides	149-160	adenosine kinase	Homo sapiens	90-106
3954325-1	1986	A sensitive radioimmunoassay has been developed for an unusual urinary nucleoside, N6-succinyladenosine (N6-SAR).	Nucleosides	71-81	sarcosine dehydrogenase	Homo sapiens	108-111
2423469-5	1986	Nucleoside analysis after alkaline hydrolysis of the RNA synthesized by the endogenous polymerase II suggested that the increased activity was due to a greater number of actively transcribing polymerase II molecules on the DNA.	Nucleosides	0-10	RNA polymerase II, I and III subunit F	Rattus norvegicus	87-100
2423469-5	1986	Nucleoside analysis after alkaline hydrolysis of the RNA synthesized by the endogenous polymerase II suggested that the increased activity was due to a greater number of actively transcribing polymerase II molecules on the DNA.	Nucleosides	0-10	RNA polymerase II, I and III subunit F	Rattus norvegicus	192-205
4053028-7	1985	This paper provides the first documentation of in vitro inhibition of dihydropyrimidine dehydrogenase activity by nucleosides.	Nucleosides	114-125	dihydropyrimidine dehydrogenase	Rattus norvegicus	70-101
4058445-5	1985	The impairment of repair accuracy was evaluated by comparing the frequency of mutations at the HGPRT locus (induction of resistance to 6TG) in irradiated cells incubated with deoxynucleosides or allowed to carry on repair synthesis in nucleoside-free medium.	Nucleosides	180-190	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	95-100
3877729-2	1985	The nucleoside transport-deficient S49 T lymphoma cell line, AE1, however, was almost as capable of incorporating thymidine into TTP as the wild type parent provided thymidine was administered at a sufficiently high concentration.	Nucleosides	4-14	solute carrier family 4 (anion exchanger), member 1	Mus musculus	61-64
3877729-4	1985	In contrast, AE1 cells were highly resistant to almost all other cytotoxic nucleosides including the thymidine analogs, 5-bromodeoxyuridine and 5-fluoro-2"-deoxyuridine 5"-monophosphate.	Nucleosides	75-86	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	13-16
2999129-0	1985	Regulation of deoxyadenosine and nucleoside analog phosphorylation by human placental adenosine kinase.	Nucleosides	33-43	adenosine kinase	Homo sapiens	86-102
2999129-12	1985	The high Km values for phosphorylation of deoxyadenosine and adenine arabinoside suggest that adenosine kinase may be less likely to phosphorylate these nucleosides in vivo than other enzymes with lower Km values.	Nucleosides	153-164	adenosine kinase	Homo sapiens	94-110
2413989-0	1985	Increased sensitivity to oxanosine, a novel nucleoside antibiotic, of rat kidney cells upon expression of the integrated viral src gene.	Nucleosides	44-54	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	127-130
3900206-3	1985	However, addition of optimal concentrations of the nucleoside, 7-methyl-8-oxoguanosine (7m8oGuo), to cultures containing antigen and IL 2 resulted in marked amplification of the underlying antibody response.	Nucleosides	51-61	interleukin 2	Homo sapiens	133-137
3875570-10	1985	In addition, the antiproliferative effect of both core compounds and their corresponding nucleosides could be potentiated by the addition of the adenosine deaminase inhibitor, deoxycoformycin.	Nucleosides	89-100	adenosine deaminase	Homo sapiens	145-164
3893160-14	1985	But after insulin, the nucleoside elicited vigorous coronary dilatation.	Nucleosides	23-33	LOC105613195	Ovis aries	10-17
3919063-3	1985	The present study was conducted to determine whether these nucleoside analogs and their dinucleotide derivatives interfere with NAD metabolism and in particular with the NAD-dependent enzyme, poly(ADP-ribose) polymerase.	Nucleosides	59-69	poly (ADP-ribose) polymerase family, member 1	Mus musculus	192-219
4040603-3	1985	Transformants expressing DHFR were selected by growth in media lacking nucleosides and contained low numbers of t-PA genes and DHFR genes.	Nucleosides	71-82	dihydrofolate reductase	Cricetulus griseus	25-29
4000960-2	1985	The results show that despite distinct differences in structure and the glycosyl bond stability, the hydrolysis of wyosine proceeds via cleavage of the C-N bond by A-1 mechanism, analogously to simple nucleosides.	Nucleosides	201-212	BCL2 related protein A1	Homo sapiens	164-167
6096813-0	1984	Synthesis of deoxyoligonucleotides containing 7-deazaadenine: recognition and cleavage by restriction endonuclease Bgl II and Sau 3AI (nucleosides and nucleotides Part 55).	Nucleosides	135-146	LPS responsive beige-like anchor protein	Homo sapiens	115-118
3919749-3	1985	These abnormal nucleosides were not found in urine of azathioprine treated patients or in 30 normal controls but were easily detected in urine from proven cases of PNP and ADA deficiency suggesting lack of in vivo inhibition of PNP and ADA by azathioprine.	Nucleosides	15-26	adenosine deaminase	Homo sapiens	172-175
3018063-2	1985	The pyridine cofactors NADPH and NADH, riboflavin, and the nucleosides 2-thiouracil and 4-thiouridine were found to sensitize the transmission of photon energy from solar radiation and monochromatic radiation (290, 334, 365, and 405 nm) to oxygen, resulting in O2- formation, as detected by superoxide dismutase-inhibitable cytochrome c reduction.	Nucleosides	59-70	cytochrome c, somatic	Homo sapiens	324-336
3874406-6	1985	The results indicate the importance of adenosine deaminase in the inactivation of nucleoside analogues and are discussed vis-a-vis the possible practical application of this inhibitor in both experimental and therapeutic applications.	Nucleosides	82-92	adenosine deaminase	Homo sapiens	39-58
6332827-7	1984	An adenosine deaminase-deficient and a purine nucleoside phosphorylase-deficient cell line, both of B cell origin, exhibited sensitivities to the nucleosides similar to those of the normal B cell lines.	Nucleosides	146-157	adenosine deaminase	Homo sapiens	3-22
6498213-3	1984	Preliminary study did not show the elevation of urinary 5"-methylthioadenosine level in malignant patients, suggesting that the cleaving enzyme, 5"-methylthioadenosine phosphorylase, very efficiently removes this nucleoside in vivo.	Nucleosides	213-223	methylthioadenosine phosphorylase	Homo sapiens	145-181
6467191-0	1984	Inactivation and reactivation of intracellular S-adenosylhomocysteinase in the presence of nucleoside analogues in rat hepatocytes.	Nucleosides	91-101	adenosylhomocysteinase	Rattus norvegicus	47-71
6467191-1	1984	Several nucleoside analogues, some of which are potent inactivators of isolated S-adenosylhomocysteinase (AdoHcyase), were tested with respect to their effect on intracellular AdoHcyase and S-adenosylhomocysteine (AdoHcy) catabolism in intact rat hepatocytes.	Nucleosides	8-18	adenosylhomocysteinase	Rattus norvegicus	80-104
6467191-1	1984	Several nucleoside analogues, some of which are potent inactivators of isolated S-adenosylhomocysteinase (AdoHcyase), were tested with respect to their effect on intracellular AdoHcyase and S-adenosylhomocysteine (AdoHcy) catabolism in intact rat hepatocytes.	Nucleosides	8-18	adenosylhomocysteinase	Rattus norvegicus	106-115
6467191-10	1984	Factors determining the effect of nucleoside analogues on intracellular AdoHcyase are discussed.	Nucleosides	34-44	adenosylhomocysteinase	Rattus norvegicus	72-81
4027943-4	1985	The results of the nucleoside incorporation were consistent with a thymidylate synthetase block; however, other explanations are offered.	Nucleosides	19-29	thymidylate synthetase	Homo sapiens	67-89
6400930-9	1984	(c) The Nt is considerable stabilized and simultaneously the Sg+ is strongly destabilized in the syn-type nucleosides relative to the anti-type.	Nucleosides	106-117	synemin	Homo sapiens	97-100
6462921-2	1984	Correlation with x-ray results permits the following Raman assignments for nucleoside conformers: C3"-endo/syn G, 623 +/- 1; C2"-endo/syn G, 671 +/- 2; C2"-endo/anti C, 782 +/- 1; C2"endo/anti T, 650 +/- 5 and ca.	Nucleosides	75-85	synemin	Homo sapiens	107-110
6462921-2	1984	Correlation with x-ray results permits the following Raman assignments for nucleoside conformers: C3"-endo/syn G, 623 +/- 1; C2"-endo/syn G, 671 +/- 2; C2"-endo/anti C, 782 +/- 1; C2"endo/anti T, 650 +/- 5 and ca.	Nucleosides	75-85	synemin	Homo sapiens	134-137
6609265-7	1984	In conclusion, either an early event in T-cell mitogenesis is highly susceptible to nucleoside toxicity or a mechanism independent of ADA is acquired during T-cell activation that allows proliferating T-cells to resist toxic concentrations of nucleoside.	Nucleosides	243-253	adenosine deaminase	Rattus norvegicus	134-137
6332827-7	1984	An adenosine deaminase-deficient and a purine nucleoside phosphorylase-deficient cell line, both of B cell origin, exhibited sensitivities to the nucleosides similar to those of the normal B cell lines.	Nucleosides	146-157	purine nucleoside phosphorylase	Homo sapiens	39-70
6697574-1	1984	In this study, we examine the influence of the intravenous administration of nucleoside-coupled spleen cells on the spontaneous development of murine lupus nephritis in young and adult BWF1 mice.	Nucleosides	77-87	WD repeat and FYVE domain containing 3	Mus musculus	185-189
6697574-3	1984	Rather, in young mice administration of nucleoside-coupled spleen cells accelerates the appearance of anti-DNA antibody suggesting that BWF1 have a specific defect in the immunoregulation of anti-DNA antibody production.	Nucleosides	40-50	WD repeat and FYVE domain containing 3	Mus musculus	136-140
6420188-3	1984	Only nucleosides were excreted during GTP catabolism by PNP deficient cells and the main product was guanosine.	Nucleosides	5-16	purine nucleoside phosphorylase	Homo sapiens	56-59
6684328-1	1983	Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2.	Nucleosides	59-69	adenosine deaminase	Cavia porcellus	143-162
6692823-0	1984	Studies on the dynamic syn-anti equilibrium in purine nucleosides and nucleotides with the aid of 1H and 13C NMR spectroscopy.	Nucleosides	54-65	synemin	Homo sapiens	23-26
6692823-1	1984	Analyses of 1H and 13C NMR spectra have been utilized to extend studies on the dynamic equilibrium syn-anti about the glycosidic bond of purine nucleosides and nucleotides.	Nucleosides	144-155	synemin	Homo sapiens	99-102
6320196-6	1984	Variations in substrate specificity, pH optima, kinetics, and sensitivity to inactivation by Pb2+ indicated the existence of multiple 5"-nucleotidase isozymes in normal erythrocytes: PyrNase and deoxyribonucleotidase(s) that might function physiologically in the conversion of DNA-derived nucleotides to diffusible nucleosides.	Nucleosides	315-326	5'-nucleotidase ecto	Homo sapiens	134-149
6319559-1	1983	Inhibition constants (Kis) were used as an estimate of the ability of various nucleoside analogues to be recognized as substrates by the deoxythymidine kinases (dTKs) of a 5-methoxymethyldeoxyuridine-resistant (MMdUr) mutant of herpes simplex virus type 1 (HSV-1) and its parent wild-type (wt).	Nucleosides	78-88	U2AF homology motif kinase 1	Homo sapiens	22-25
6673453-0	1983	Effect of glutamine and nucleosides on prolactin secretion in the rat.	Nucleosides	24-35	prolactin	Rattus norvegicus	39-48
6673453-1	1983	The effect of glutamine and some nucleosides (cytidine and uridine) on basal and stimulated prolactin release was investigated in vivo and in vitro.	Nucleosides	33-44	prolactin	Rattus norvegicus	92-101
6673453-6	1983	These results suggest that both glutamine and the nucleosides cytidine and uridine may influence the activity of the hypothalamic-hypophyseal-prolactin axis, probably via an interference with endogenous neurotransmitters.	Nucleosides	50-61	prolactin	Rattus norvegicus	142-151
6603986-2	1983	Erythropoietin at 400 mU/ml caused a 40-80 fold increase in the incorporation of the labeled nucleoside.	Nucleosides	93-103	erythropoietin	Mus musculus	0-14
6688440-2	1983	By using a highly sensitive fluorimetric assay and collecting specimens into an inhibitor of adenosine deaminase, we have accurately measured purine nucleoside and hypoxanthine-xanthine levels in arterial and venous blood, in cerebrospinal fluid and in bone marrow aspirates.	Nucleosides	149-159	adenosine deaminase	Homo sapiens	93-112
6683781-3	1983	Such cellular incorporation is particularly difficult to achieve because this nucleoside is rapidly demethylated by adenosine deaminase.	Nucleosides	78-88	adenosine deaminase	Cricetulus griseus	116-135
6411095-8	1983	It is postulated that the corresponding adenine analog 5"-phosphorylated nucleotides are the primary active metabolites of these MTA analogs, having been formed by the cleavage of these nucleosides to free adenine analogs by MTAPase, followed by the conversion of these base analogs to analog nucleotides by adenine phosphoribosyltransferase and the enzymes of adenine nucleotide phosphorylation.	Nucleosides	186-197	methylthioadenosine phosphorylase	Homo sapiens	225-232
6411095-8	1983	It is postulated that the corresponding adenine analog 5"-phosphorylated nucleotides are the primary active metabolites of these MTA analogs, having been formed by the cleavage of these nucleosides to free adenine analogs by MTAPase, followed by the conversion of these base analogs to analog nucleotides by adenine phosphoribosyltransferase and the enzymes of adenine nucleotide phosphorylation.	Nucleosides	186-197	adenine phosphoribosyltransferase	Homo sapiens	308-341
6304066-10	1983	These results support an uptake mechanism of the AMP-derived adenosine in which the adenosine formed by ecto-5"-nucleotidase in the blood-sinusoidal plasma membrane of hepatocytes, is taken up by the nucleoside transport system located at the plasma membrane side by side with ecto-5"-nucleotidase.	Nucleosides	200-210	5' nucleotidase, ecto	Rattus norvegicus	104-124
6304066-10	1983	These results support an uptake mechanism of the AMP-derived adenosine in which the adenosine formed by ecto-5"-nucleotidase in the blood-sinusoidal plasma membrane of hepatocytes, is taken up by the nucleoside transport system located at the plasma membrane side by side with ecto-5"-nucleotidase.	Nucleosides	200-210	5' nucleotidase, ecto	Rattus norvegicus	277-297
6405798-3	1983	The nucleoside also caused an increased release of beta-glucuronidase, a lysosomal enzyme.	Nucleosides	4-14	glucuronidase, beta	Mus musculus	51-69
6840085-3	1983	We found a high anti-syn activation energy in the case of the pyrimidine nucleosides C and m5C, whereas for the purine nucleosides G, m6G, m7G and m8G only moderate anti-syn energetic barriers were calculated.	Nucleosides	73-84	synemin	Homo sapiens	21-24
6840085-3	1983	We found a high anti-syn activation energy in the case of the pyrimidine nucleosides C and m5C, whereas for the purine nucleosides G, m6G, m7G and m8G only moderate anti-syn energetic barriers were calculated.	Nucleosides	73-84	synemin	Homo sapiens	170-173
6860359-3	1983	Developmental profiles of enzymes of nucleoside metabolism showed adenosine deaminase and purine nucleoside phosphorylase to be greatest in thymus around day 20 and to decrease for animals older than 60 days.	Nucleosides	37-47	adenosine deaminase	Mus musculus	66-85
6337875-2	1983	When no hormones were present, N6-phenylisopropyladenosine had little or no effect; however, the nucleoside potentiated insulin inhibition of catecholamine-stimulated events, such as lipolysis, and, conversely, diminished or blocked catecholamine inhibition of insulin-stimulated processes, such as 2-deoxyglucose uptake, glucose oxidation and esterification, even under conditions where N6-phenylisopropyladenosine, alone, was ineffective in reversing catecholamine actions.	Nucleosides	97-107	insulin	Homo sapiens	120-127
6337875-2	1983	When no hormones were present, N6-phenylisopropyladenosine had little or no effect; however, the nucleoside potentiated insulin inhibition of catecholamine-stimulated events, such as lipolysis, and, conversely, diminished or blocked catecholamine inhibition of insulin-stimulated processes, such as 2-deoxyglucose uptake, glucose oxidation and esterification, even under conditions where N6-phenylisopropyladenosine, alone, was ineffective in reversing catecholamine actions.	Nucleosides	97-107	insulin	Homo sapiens	261-268
6664873-0	1983	Introduction of carbon substituents at C-2 position of purine nucleosides.	Nucleosides	62-73	complement C2	Homo sapiens	39-42
6304349-3	1983	Further, it was inhibited to a lesser degree than the WT dTK by the nucleoside analogs MMdU and arabinosylthymine (araT), which suggests that one of the effects of the mutation was a selective alteration in substrate recognition by the dTK.	Nucleosides	68-78	Tachykinin	Drosophila melanogaster	57-60
6304349-3	1983	Further, it was inhibited to a lesser degree than the WT dTK by the nucleoside analogs MMdU and arabinosylthymine (araT), which suggests that one of the effects of the mutation was a selective alteration in substrate recognition by the dTK.	Nucleosides	68-78	Tachykinin	Drosophila melanogaster	236-239
6304349-11	1983	These findings suggest that a mutation in the dTK polypeptide has affected recognition not only of nucleoside substrates but of the nucleotide substrate dTMP as well, which agrees with the suggestion of Chen et al.	Nucleosides	99-109	Tachykinin	Drosophila melanogaster	46-49
6407475-2	1983	The effects of a number of nucleosides related to 5"-methylthioadenosine on the activities of S-adenosylhomocysteine hydrolase, 5"-methylthioadenosine phosphorylase, spermidine synthase and spermine synthase were investigated.	Nucleosides	27-38	methylthioadenosine phosphorylase	Homo sapiens	128-164
6100584-9	1983	For uptake of purine nucleotides sequential action of ecto-5"-nucleotidase (ecto-5"-NT), nucleoside carrier and intracellular metabolism is necessary.	Nucleosides	89-99	5'-nucleotidase ecto	Homo sapiens	54-74
6100584-9	1983	For uptake of purine nucleotides sequential action of ecto-5"-nucleotidase (ecto-5"-NT), nucleoside carrier and intracellular metabolism is necessary.	Nucleosides	89-99	5'-nucleotidase ecto	Homo sapiens	76-86
6299600-7	1983	Ac-4 HAQO-modified DNA is thermally destabilized: when 1% of the bases of DNA were modified by Ac-4 HAQO, its melting temperature decreased 1.2 degrees C. Enzymatic degradation of Ac-4 HAQO-modified native and denatured DNA"s to nucleosides was performed.	Nucleosides	229-240	adenylate cyclase 4	Homo sapiens	0-4
6299600-7	1983	Ac-4 HAQO-modified DNA is thermally destabilized: when 1% of the bases of DNA were modified by Ac-4 HAQO, its melting temperature decreased 1.2 degrees C. Enzymatic degradation of Ac-4 HAQO-modified native and denatured DNA"s to nucleosides was performed.	Nucleosides	229-240	adenylate cyclase 4	Homo sapiens	95-99
6299600-7	1983	Ac-4 HAQO-modified DNA is thermally destabilized: when 1% of the bases of DNA were modified by Ac-4 HAQO, its melting temperature decreased 1.2 degrees C. Enzymatic degradation of Ac-4 HAQO-modified native and denatured DNA"s to nucleosides was performed.	Nucleosides	229-240	adenylate cyclase 4	Homo sapiens	95-99
6664873-1	1983	A series of new purine nucleosides which have carbon substituents at their C-2 position were synthesized by non-aqueous diazotization/deamination of 2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)purine (1) with isoamyl nitrite in aromatic solvents and by palladium-catalyzed alkynylation of 2-iodo-adenosine (4) with terminal alkynes.	Nucleosides	23-34	complement C2	Homo sapiens	75-78
7154718-4	1982	The extent and duration of the accumulation was increased by multiple doses of arabinosyladenine and by giving the nucleoside in combination with erythro-9-(2-hydroxy-3-nonyl)-adenine, a potent inhibitor of adenosine deaminase, which significantly increased its concentration in the liver.	Nucleosides	115-125	adenosine deaminase	Rattus norvegicus	207-226
6845818-1	1983	The nucleoside antibiotic formycin, 7-amino-3-(beta-D-ribofuranosyl)pyrazolo(4,3-d)pyrimidine, a structural analogue of adenosine, is deaminated about 10-fold faster by adenosine deaminase than adenosine itself, and is therefore a superior substrate for both routine assays and kinetic studies with the purified enzyme.	Nucleosides	4-14	adenosine deaminase	Homo sapiens	169-188
6279182-3	1982	In case of brain PDE, on the contrary, the effect of the nucleosides was much more pronounced in the enzyme preparation coupled with the protein activator, calmodulin.	Nucleosides	57-68	calmodulin 1	Homo sapiens	156-166
6178581-8	1982	Insulin apparently stimulates the uptake of phosphorylation (or both) of free nucleosides.	Nucleosides	78-89	insulin	Homo sapiens	0-7
6285720-7	1982	These studies indicate that cotherapy with ara-A and an adenosine deaminase inhibitor was a reasonable alternative therapy for keratitis due to mutants resistant to therapy with nucleoside analogs which require the virus-specified deoxypyrimidine kinase or DNA polymerase, while ara-A alone was not an effective alternative.	Nucleosides	178-188	adenosine deaminase	Homo sapiens	56-75
7108531-5	1982	The most prominent nucleoside in the 5"-penultimate position was 6-methyl-2"-O-methyladenosine [m6A(m)] followed by 2"-O-methyladenosine [A(m)], which together contributed to nearly 70% of both cap 1 and cap 2 structures.	Nucleosides	19-29	cyclase associated actin cytoskeleton regulatory protein 1	Rattus norvegicus	194-199
7044591-3	1982	A comparison of the mechanism of action of VP16-213 and podophyllotoxin has revealed that although both drugs inhibit the uptake of nucleosides into HeLa cells, they exhibit other biological properties which are quite distinct.	Nucleosides	132-143	host cell factor C1	Homo sapiens	43-47
7108531-5	1982	The most prominent nucleoside in the 5"-penultimate position was 6-methyl-2"-O-methyladenosine [m6A(m)] followed by 2"-O-methyladenosine [A(m)], which together contributed to nearly 70% of both cap 1 and cap 2 structures.	Nucleosides	19-29	cyclase associated actin cytoskeleton regulatory protein 2	Rattus norvegicus	204-209
7317429-5	1981	Relative to S49 cells, AE1 cells were resistant to the antiproliferative effects of tubercidin and showdomycin, but differences between the two cell lines in sensitivity toward arabinosyladenine were minor, suggesting that nucleoside transport activity was required for cytotoxicity of tubercidin and showdomycin, but not for that of arabinosyladenine.	Nucleosides	223-233	solute carrier family 4 (anion exchanger), member 1	Mus musculus	23-26
6785725-6	1981	The e domain, however, is found to be of major importance in several chemically modified furanoses including certain pyrimidine deoxynucleosides damaged by radiation and various nucleosides and nucleotides forced by bulky substituents on the base into unusual syn glycosyl arrangements.	Nucleosides	133-144	synemin	Homo sapiens	260-263
6277103-11	1981	After enzymatic digestion of DNA BaP-nucleoside adducts are detected by HPLC.	Nucleosides	37-47	prohibitin 2	Rattus norvegicus	33-36
6789872-4	1981	The other enzyme, purine nucleoside phosphorylase (PN Pase), catalyzed the synthesis of the product nucleoside by utilizing the pentose 1-phosphate ester generated from the phosphorolysis of the pyrimidine nucleoside.	Nucleosides	25-35	purine nucleoside phosphorylase	Homo sapiens	51-58
519007-3	1979	The subsequent nucleoside treatment (up to 15 and 20 days) accelerates to a different degree the reparative processes after CCl4 withdrawal.	Nucleosides	15-25	C-C motif chemokine ligand 4	Rattus norvegicus	124-128
7470463-2	1981	S-Adenosylhomocysteine hydrolase from lupin seeds is able to utilize all of these nucleosides except inosine to synthesize analogues of S-adenosylhomocysteine.	Nucleosides	82-93	adenosylhomocysteinase	Homo sapiens	0-32
7470463-2	1981	S-Adenosylhomocysteine hydrolase from lupin seeds is able to utilize all of these nucleosides except inosine to synthesize analogues of S-adenosylhomocysteine.	Nucleosides	82-93	5'-nucleotidase, cytosolic IIIA	Homo sapiens	38-43
7028853-2	1981	This purine nucleoside has been shown to possess antiviral activity against several ADN viruses, including herpes simplex virus, but it is ineffective against ARN viruses.	Nucleosides	12-22	complement factor D	Homo sapiens	84-87
6108130-9	1980	Inhibition of IMP dehydrogenase activity by mycophenolic acid caused a 12- and 3-fold increase in the rate of production of labelled base and nucleoside in the parent and HGPRT- cells respectively.	Nucleosides	142-152	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	171-176
7191477-7	1980	The model discussed here is an example of this most emphatic distinctiveness, as the nucleosides at the 5" ends of the intercalation sites are C-3"-endo and syn and at the 3" ends are C-2"-endo and anti.	Nucleosides	85-96	synemin	Homo sapiens	157-160
7379208-8	1980	Both the total binding and specific metabolite-nucleoside adducts in the placenta correlated with fluorometrically measured aryl hydrocarbon hydroxylase (AHH) activity and with the amount of dihydrodiol formed.	Nucleosides	47-57	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	124-152
7379208-8	1980	Both the total binding and specific metabolite-nucleoside adducts in the placenta correlated with fluorometrically measured aryl hydrocarbon hydroxylase (AHH) activity and with the amount of dihydrodiol formed.	Nucleosides	47-57	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	154-157
16592840-6	1980	The circular dichroism spectra of 3-deazaadenosine, 8-(alpha-hydroxyisopropyl)-adenosine, and other purine nucleosides having a strong preference for the syn conformation are presented and compared with the theoretical results.	Nucleosides	107-118	synemin	Homo sapiens	154-157
90084-3	1979	Further evidence that the adenosine effect is related to changes in cAMP levels is that the nucleoside inhibits only in the first stage of antigen-induced histamine release and fails to inhibit the release caused by ionophore A23187.	Nucleosides	92-102	cathelicidin antimicrobial peptide	Homo sapiens	68-72
7408842-0	1980	NMR studies in the syn-anti dynamic equilibrium in purine nucleosides and nucleotides.	Nucleosides	58-69	synemin	Homo sapiens	19-22
7408842-1	1980	The syn in equilibrium anti equilibrium conformation about the glycosidic bond of purine nucleosides and 5"-nucleotides in different solvent systems has been investigated by means of 1H NMR spectroscopy.	Nucleosides	89-100	synemin	Homo sapiens	4-7
7408842-5	1980	The measured values of the vicinal coupling constants between H-1" and the C-8 and C-4 carbons were employed to evaluate approximately the glycosidic angles chi of the nucleosides in the conformations syn and anti.	Nucleosides	168-179	homeobox C8	Homo sapiens	75-78
7408842-5	1980	The measured values of the vicinal coupling constants between H-1" and the C-8 and C-4 carbons were employed to evaluate approximately the glycosidic angles chi of the nucleosides in the conformations syn and anti.	Nucleosides	168-179	complement C4A (Rodgers blood group)	Homo sapiens	83-86
7408842-5	1980	The measured values of the vicinal coupling constants between H-1" and the C-8 and C-4 carbons were employed to evaluate approximately the glycosidic angles chi of the nucleosides in the conformations syn and anti.	Nucleosides	168-179	synemin	Homo sapiens	201-204
552391-3	1979	The nucleosides in each group are separated by isocratic elution from a preparative Partisil 10-SCX column and high-performance liquid chromatography at ambient temperature.	Nucleosides	4-15	scleraxis bHLH transcription factor	Rattus norvegicus	96-99
470943-3	1979	A method for determining the equilibrium constant of sin-anti-states in the aqueous solution of purine and pyrimidine nucleotides and nucleosides has been proposed.	Nucleosides	134-145	embryonal Fyn-associated substrate	Homo sapiens	53-56
38755-6	1979	The results suggest that the enzyme which degrades nucleoside-5"-phosphate to nucleoside and inorganic phosphate is not acid phosphatase but 5"-nucleotidase.	Nucleosides	51-61	5'-nucleotidase ecto	Homo sapiens	141-156
497209-8	1979	The comparison has been extended to syn nucleosides which show opposite trends in the sugar conformation and g+ distribution.	Nucleosides	40-51	synemin	Homo sapiens	36-39
436113-1	1979	N6(Methylnitroso) adenosine (M6(NO)Ado) is found readily under acidic conditions by the interaction of nitrite with 6-methyladenosine, a naturally-occurring nucleoside.	Nucleosides	157-167	homeobox A7	Mus musculus	29-38
87197-0	1979	Inhibition of human lung cyclic GMP and cyclic AMP phosphodiesterases by certain nucleosides, nucleotides, and pharmacological phosphodiesterase inhibitors.	Nucleosides	81-92	5'-nucleotidase, cytosolic II	Homo sapiens	32-35
105760-3	1979	Nucleoside analog inhibition studies have been conducted on thyroidal purine nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) which catalyzed an ordered bi-bi type mechanism where the first substrate is inorganic phosphate and the last product is ribose 1-phosphate.	Nucleosides	0-10	purine nucleoside phosphorylase	Homo sapiens	103-154
105760-6	1979	These studies together with alternate substrate studies indicate that nucleoside binding requires a functional group capable of hydrogen bonding at the 6-position of the purine ring and that the orientation of the bound substrate may be syn.	Nucleosides	70-80	synemin	Homo sapiens	237-240
758311-5	1979	Growth rate and transport studies indicate that the lack of expression of the nucleoside transport in AE1 cells is recessive in intraspecies cell-cell hybrids.	Nucleosides	78-88	solute carrier family 4 (anion exchanger), member 1	Mus musculus	102-105
284380-0	1979	Conformation of nucleosides: circular dichroism study on the syn-anti conformational equilibrium of 2-substituted benzimidazole nucleosides.	Nucleosides	16-27	synemin	Homo sapiens	61-64
718950-6	1978	Adenosine deaminase abolished the inhibitory effect of the nucleoside, whilst theophylline had no effect on activity either in the absence or presence of adenosine.	Nucleosides	59-69	adenosine deaminase	Bos taurus	0-19
232427-1	1979	The activity of uridine kinase, a key enzyme in the salvage pathway for pyrimidine bases and nucleosides and for the activation of the corresponding chemotherapeutic analogs, varied 10-fold in a series of human colon adenosarcomas; similar variations were observed with other tumor types.	Nucleosides	93-104	uridine-cytidine kinase 2	Homo sapiens	16-30
739982-3	1978	The analysis of terminal pNp nucleotides revealed a relatively high ratio of pPyp in the cleaved dsRNA, whereas the nucleosides in 5"-terminal pNp of ssRNA showed nearly random distribution.	Nucleosides	116-127	purine nucleoside phosphorylase	Rattus norvegicus	143-146
149137-0	1978	Effect of phosphate esters, nucleotides and nucleosides on 5"-nucleotidase of cultured mouse macrophages.	Nucleosides	44-55	5' nucleotidase, ecto	Mus musculus	59-74
206294-5	1978	For the inhibitory activity of pNp to occur, the intactness of the nucleoside moiety as a whole was shown to be necessary, the activity level depending on the structure of both the base and the sugar components.	Nucleosides	67-77	purine nucleoside phosphorylase	Homo sapiens	31-34
207871-4	1978	Inhibition of vasopressin-induced water movement is half-maximal at the following alkaloid concentrations: colchicine, 1.8 X 10(-6) M; podophyllotoxin, 5 X 10(-7)M; and vinblastine, 1 X 10(-7)M. The characteristics of the specificity, time-dependence and temperature-dependence of the inhibitory effect of colchicine are similar to the characteristics of the interaction of this drug with tubulin in vitro, and they differ from those of its effect on nucleoside transport.	Nucleosides	451-461	arginine vasopressin	Homo sapiens	14-25
77682-6	1978	The corresponding nucleosides, uridine and cytidine, show a preference for syn (chiCN=240 degrees) and gg and anti(chiCN=0 degrees) and gg , respectively.	Nucleosides	18-29	synemin	Homo sapiens	75-78
96828-0	1978	Purification and nucleoside composition of a Q* - containing aspartic acid tRNA from Drosophila.	Nucleosides	17-27	transfer RNA:Lysine-TTT 2-2	Drosophila melanogaster	75-79
205837-2	1978	The structure of this novel nucleoside was shown to be N6, O2"-dimethyladenosine (m6Am) by mass spectrometry of its trimethylsilyl derivative and by comparison with the mass spectra of N6- and O-2" monmethyl model compounds.	Nucleosides	28-38	immunoglobulin kappa variable 1D-39	Homo sapiens	185-196
623761-3	1978	The results indicate an anti conformation for Xcn and a gg conformation for phiC(4")-C(5") for C(2")-endo 8-aza analogs compared to the syn and gg conformation for the corresponding purine nucleosides.	Nucleosides	189-200	synemin	Homo sapiens	136-139
203511-1	1978	The effect of cya and crp mutations on the expression of the activity of nucleoside catabolizing genes has been studied in Escherichia coli.	Nucleosides	73-83	catabolite gene activator protein	Escherichia coli	22-25
115663-2	1978	After each transfusion with PNP-containing erythrocytes a decrease in accumulated nucleosides and their deoxy compounds was observed, whereas uric acid excretion and serum uric acid increased.	Nucleosides	82-93	purine nucleoside phosphorylase	Homo sapiens	28-31
203511-2	1978	It is found that cya and crp mutants lose their ability to grow on nucleosides as carbon sources in spite of the preservation of the basal levels of nucleoside catabolizing enzymes, found in cell-free extracts of cya and crp mutants.	Nucleosides	67-78	catabolite gene activator protein	Escherichia coli	25-28
911810-0	1977	Modified nucleosides and conformation of anticodon loops: crystal structure of t6A and g6A.	Nucleosides	9-20	dimethylarginine dimethylaminohydrolase 2	Homo sapiens	87-90
922011-7	1977	In the other case, when the syn and anti conformations are sterically accessible, the orientation of the base may be completely different from one nucleoside to the other.	Nucleosides	147-157	synemin	Homo sapiens	28-31
896486-1	1977	Extensive incorporation of oxygen-18 at position O4 of the pyrimidine nucleus results from exchange between H218O and nucleosides or bases in 1N HC1 at 100 degrees.	Nucleosides	118-129	CYCS pseudogene 39	Homo sapiens	145-148
884102-3	1977	The chemical shift of the ribose C2"-H and especially the difference in chemical shifts between the C1"-H and C2"-H resonances clearly indicated whether the nucleoside exists in a syn glycosyl conformation (the C8-dimethylamino derivatives) or as a flexible syn-anti mixture (the monomethylamino and amino derivatives).	Nucleosides	157-167	synemin	Homo sapiens	180-183
884102-3	1977	The chemical shift of the ribose C2"-H and especially the difference in chemical shifts between the C1"-H and C2"-H resonances clearly indicated whether the nucleoside exists in a syn glycosyl conformation (the C8-dimethylamino derivatives) or as a flexible syn-anti mixture (the monomethylamino and amino derivatives).	Nucleosides	157-167	synemin	Homo sapiens	258-261
195585-3	1977	Further, comparisons of the Km values of isolated uridine kinases with those for cellular uptake of pyrimidine nucleosides and their rate of intracellular phosphorylation suggest that nucleoside-transport systems play a rate-limiting role in nucleoside analogue activation and consequently that it is impossible to estimate the Km of uridine kinase in the intact cell.	Nucleosides	111-121	uridine-cytidine kinase 2	Homo sapiens	50-64
888401-4	1977	Out of the necrosis area 5-nucleotidase maintained the high activity but both "non-adenosine" pathway of AMP degradation and adenosine splitting were inhibited; this promoted the nucleoside formation and maintained its level in the tissue.	Nucleosides	179-189	5'-nucleotidase ecto	Canis lupus familiaris	25-39
557343-6	1977	The modified nucleic acids were completely hydrolyzed to nucleosides by the combination of venom exonuclease, deoxyribonuclease I and alkaline phosphatase.	Nucleosides	57-68	deoxyribonuclease 1	Bos taurus	110-129
564429-1	1977	At 5 microgram/ml, insulin stimulates hexose, A-system amino acid, and nucleoside transport by serum-starved chick embryo fibroblasts (CEF).	Nucleosides	71-81	insulin	Gallus gallus	19-26
875640-1	1977	A comparison of the mechanism of action of VP 16-213 and podophyllotoxin has revealed that although both drugs inhibit nucleoside uptake in HeLa cells, they exhibit other biological properties which are quite distinct.	Nucleosides	119-129	host cell factor C1	Homo sapiens	43-48
1069980-1	1976	One of the factors required for the antiviral activity of the synthetic nucleoside, ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide), is the ability of the molecule to adopt the substrate conformation specified by the enzyme for which it is a competitive inhibitor, inosine 5"-phosphate dehydrogenase (IMP:NAD+ oxidoreductase, EC 1.2.1.14).	Nucleosides	72-82	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	326-340
999951-4	1976	Nucleosides fingerprint analysis of each iso-tRNA species confirms the anticodon structures previously suggested for tRNA2Ala (IGC), tRNA2bGly (U-CC) (U-CC) and tRNA2bSer (IGA).	Nucleosides	0-11	acetylglucosaminyltransferase	Bombyx mori	133-142
186698-1	1976	The regulation of the synthesis of nucleoside metabolizing enzymes has been studied in cya and crp mutant strains of Escherichia coli.	Nucleosides	35-45	catabolite gene activator protein	Escherichia coli	95-98
186698-4	1976	It also seems that nucleosides serve as poor carbon sources for cya and crp mutants; this could not solely be explained by low levels of nucleoside metabolizing enzymes nor by a deficiency in nucleoside uptake.	Nucleosides	19-30	catabolite gene activator protein	Escherichia coli	72-75
186698-4	1976	It also seems that nucleosides serve as poor carbon sources for cya and crp mutants; this could not solely be explained by low levels of nucleoside metabolizing enzymes nor by a deficiency in nucleoside uptake.	Nucleosides	19-29	catabolite gene activator protein	Escherichia coli	72-75
822276-0	1976	Multiple regulation of nucleoside catabolizing enzymes: effects of a polar dra mutation on the deo enzymes.	Nucleosides	23-33	solute carrier family 26 member 3	Homo sapiens	75-78
932021-2	1976	Kinetic constants were determined for 34 nucleoside substrates of deoxycytidine kinase (EC 2.7.1.74) from calf thymus.	Nucleosides	41-51	deoxycytidine kinase	Bos taurus	66-86
1024588-2	1976	amylozyma 9a has endonucleolytic character of the action on RNA, it splits in RNA 5"-phosphodiester bonds of GpXp type (where X is any nucleoside).	Nucleosides	135-145	glutathione peroxidase 3	Homo sapiens	109-113
174715-4	1976	The only internal methylated nucleoside, N6-methyladenosine (m6A), was found exclusively as m6ApC and Apm6ApC after digestion with RNase A, T1, and alkaline phosphatase.	Nucleosides	29-39	ribonuclease A family member 1, pancreatic	Homo sapiens	131-138
175792-0	1976	Affect of spleen and snake venom phosphodiesterases on nucleotides containing nucleosides in the syn conformation.	Nucleosides	78-89	synemin	Homo sapiens	97-100
1148239-6	1975	A nucleoside with ultraviolet spectral properties similar to N-4-acetylcytidine was found in tRNA-Lys-5 and a nucleoside with chromatographic properties the same as N-[9-beta-D-ribofuranosyl)-purin-6-yl-carbamoyl] threonine was found in tRNA-Lys-2.	Nucleosides	2-12	transfer RNA:Lysine-CTT 1-3	Drosophila melanogaster	237-247
1035127-5	1976	The exogenously added nucleoside caused inhibition of cell growth within 3 h and cell death within 36 h at concentrations as low as 0.4 muM.	Nucleosides	22-32	latexin	Homo sapiens	136-139
173983-0	1975	Structural requirements for activity of nucleosides as substrates for adenosine kinase: orientation of substituents on the pentofuranosyl ring.	Nucleosides	40-51	adenosine kinase	Homo sapiens	70-86
51874-1	1975	BALB/c and SJL mice were treated with nucleosides-IgG1 as a tolerogen, before either primary or secondary immunization with nucleosides-keyhole limpet hemocyanin.	Nucleosides	38-49	LOC105243590	Mus musculus	50-54
51874-4	1975	Multiple doses of nucleosides-IgG1 tolerogen given before the primary or secondary immunization effectively suppressed the secondary and tertiary anti-nucleoside responses.	Nucleosides	18-29	LOC105243590	Mus musculus	30-34
51874-4	1975	Multiple doses of nucleosides-IgG1 tolerogen given before the primary or secondary immunization effectively suppressed the secondary and tertiary anti-nucleoside responses.	Nucleosides	18-28	LOC105243590	Mus musculus	30-34
1176969-1	1975	A synthetic nucleoside analogue 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboamide (ribavirin or RTCA) inhibits the replication of tissue culture of influenza B virus and also a wide range of influenza A viruses of human, animal and avian origin.	Nucleosides	12-22	RNA 3'-terminal phosphate cyclase	Homo sapiens	97-101
1176969-3	1975	The inhibitory effects of RTCA on influenza A virus replication in tissue culture is reversed by a molar excess of guanosine or zanthosine which suggests that the compound acts at an early stage of virus RNA synthesis prior to the utilisation of the latter nucleosides.	Nucleosides	257-268	RNA 3'-terminal phosphate cyclase	Homo sapiens	26-30
1148239-6	1975	A nucleoside with ultraviolet spectral properties similar to N-4-acetylcytidine was found in tRNA-Lys-5 and a nucleoside with chromatographic properties the same as N-[9-beta-D-ribofuranosyl)-purin-6-yl-carbamoyl] threonine was found in tRNA-Lys-2.	Nucleosides	110-120	transfer RNA:Lysine-CTT 1-3	Drosophila melanogaster	237-247
1151968-3	1975	A number of nucleosides of 2-azaadenine (4-amino-7H-imidazo[4,5-d]-1,2,3-triazine) were prepared by a previously described route, and some of these were deaminated by means of adenosine deaminase.	Nucleosides	12-23	adenosine deaminase	Homo sapiens	176-195
1111552-0	1975	A possible association between the nucleoside transport system of human erythrocytes and adenosine deaminase.	Nucleosides	35-45	adenosine deaminase	Homo sapiens	89-108
46255-1	1975	The administration of nucleosides coupled covalently to the copolymer of D-glutamic acid and D-lysine (D-GL) or to its stereoisomer, L-GL, induces a state of nucleoside (NUC)-specific tolerance in inbred SJL and BALB/c mice, irrespective of their immune status at the time of treatment.	Nucleosides	22-33	legless	Mus musculus	133-137
46255-1	1975	The administration of nucleosides coupled covalently to the copolymer of D-glutamic acid and D-lysine (D-GL) or to its stereoisomer, L-GL, induces a state of nucleoside (NUC)-specific tolerance in inbred SJL and BALB/c mice, irrespective of their immune status at the time of treatment.	Nucleosides	22-32	legless	Mus musculus	133-137
1109791-9	1975	ara-C was the predominant nucleoside present in hydrolysates of ara-CTP fractions.	Nucleosides	26-36	solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1	Mus musculus	68-71
4835378-0	1974	Conformation of nucleosides: circular dichroism study of solvent effect on the syn-anti conformational equilibrium of pyrimidine nucleosides.	Nucleosides	16-27	synemin	Homo sapiens	79-82
10793738-2	1974	The mechanism of formation of this novel nucleoside was elucidated using adenosine tritiated at C-8 and C-2, and was found to deformylate exclusively at C-2.	Nucleosides	41-51	complement C2	Rattus norvegicus	104-107
10793738-2	1974	The mechanism of formation of this novel nucleoside was elucidated using adenosine tritiated at C-8 and C-2, and was found to deformylate exclusively at C-2.	Nucleosides	41-51	complement C2	Rattus norvegicus	153-156
4415066-4	1974	For nucleosides in non-standard conformation (i.e. syn-conformation of guanine in GpGpCp) the physical alteractions may be seen in those cases, when the substituting group affects the initial conformation or the interplane base contacts via, for instance, blocking NH(2)-group of guanine in GpUp.	Nucleosides	4-15	synemin	Homo sapiens	51-54
5941210-0	1966	Tryptophan pyrrolase activity: effects of cyclic-AMP, purines, pyrimidines, nucleosides, and nucleotides.	Nucleosides	76-87	tryptophan 2,3-dioxygenase	Homo sapiens	0-20
4521417-1	1974	Cytidine deaminase, an enzyme that catalyses the deamination of both cytidine and its nucleoside analogues including the antineoplastic agents cytosine arabinoside (ara-C) and 5-azacytidine (5-azaC), has been partially purified from normal and leukemic human granulocytes.	Nucleosides	86-96	cytidine deaminase	Homo sapiens	0-18
5317637-0	1971	The effects of some nucleosides and dithiothreitol on the stability and activity of liver phenylalanine hydroxylase.	Nucleosides	20-31	phenylalanine hydroxylase	Homo sapiens	90-115
5550253-0	1971	Molecular conformation of orotidine, a naturally occurring nucleoside, in the syn conformation in aqueous solution.	Nucleosides	59-69	synemin	Homo sapiens	78-81
11945362-1	1970	The nucleoside was crystallized from aqueous methanol as its iodide monohydrate in space group P2(1).	Nucleosides	4-14	H3 histone pseudogene 16	Homo sapiens	95-100
5448239-3	1970	Conformational analysis of nucleosides and nucleotides with syn glycosidic torsional angle.	Nucleosides	27-38	synemin	Homo sapiens	60-63
4596141-2	1974	The sites within the tRNA sequence of nucleosides methylated by the action of enzymes from mouse colon, rat kidney and tumours of these tissues acting on tRNA(Asp) from yeast and on tRNA(Glu) (2), tRNA(fMet) and tRNA(Val) (1) from Escherichia coli were determined.	Nucleosides	38-49	mitochondrially encoded tRNA glycine	Homo sapiens	182-194
4542340-1	1973	Four nucleosides were covalently bound to isogeneic mouse immunoglobulin G (IgG) and injected into New Zealand mice.	Nucleosides	5-16	immunoglobulin heavy variable V1-62	Mus musculus	58-74
4542340-1	1973	Four nucleosides were covalently bound to isogeneic mouse immunoglobulin G (IgG) and injected into New Zealand mice.	Nucleosides	5-16	immunoglobulin heavy variable V1-62	Mus musculus	76-79
4355790-0	1973	Nucleoside transport in normal and polyoma-transformed cells: kinetic differences following adenosine and serum or insulin stimulation.	Nucleosides	0-10	insulin	Homo sapiens	115-122
5012976-0	1972	Mechanism of the isotopic exchange of the C-8 hydrogen of purines in nucleosides and in deoxyribonucleic acid.	Nucleosides	69-80	homeobox C8	Homo sapiens	42-45
33909515-6	2021	EXPERT OPINION: : Considerable advances have been reported in the design of nucleotide/nucleoside-based CD73 inhibitors, after the X-ray crystal structure of the enzyme in complex with the non-hydrolyzable ADP analog, adenosine (alpha,beta)-methylene diphosphate (AMPCP), was reported.	Nucleosides	87-97	5'-nucleotidase ecto	Homo sapiens	104-108
14240591-0	1964	CONVERSION OF NUCLEOSIDE TO SEDOHEPTULOSE MONOPHOSPHATE BY MOUSE LIVER INJURED WITH CCL-4.	Nucleosides	14-24	chemokine (C-C motif) ligand 4	Mus musculus	84-89
14253597-1	1964	I. INHIBITION OF ADENOSINE DEAMINASE BY ISOSTERIC NUCLEOSIDES.	Nucleosides	50-61	adenosine deaminase	Homo sapiens	17-36
33576905-3	2021	For this, we analyzed the interaction of extracellular nucleotides and nucleosides with the purinergic receptors P1 and P2, as well as the influence of ectonucleotidase enzymes (CD39 and CD73) on tumor progression.	Nucleosides	71-82	crystallin gamma F, pseudogene	Homo sapiens	113-122
34000809-3	2021	In this paper, we show that the combination of geometry optimizations with the HF-3c method with single point energies at the RI-MP2 level results in accurate results for the puckering potential energy surface (PES) of DNA and RNA nucleosides while significantly reducing the necessary computational time.	Nucleosides	231-242	tryptase pseudogene 1	Homo sapiens	129-132
5443531-0	1970	The interaction of the nucleoside analogues, formycins A and B, with xanthine oxidase and hepatic aldehyde oxidase.	Nucleosides	23-33	aldehyde oxidase 1	Homo sapiens	98-114
33979727-0	2021	SAMHD1 mutations in mantle cell lymphoma are recurrent and confer in vitro resistance to nucleoside analogues.	Nucleosides	89-99	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
33939417-3	2021	Here we use structural information available for ADAR2-RNA complexes to guide the design of nucleoside analogs for the position in the guide strand that contacts a conserved glutamic acid residue in ADARs (E488 in human ADAR2), which flips the adenosine into the ADAR active site for deamination.	Nucleosides	92-102	adenosine deaminase RNA specific B1	Homo sapiens	49-54
33939417-3	2021	Here we use structural information available for ADAR2-RNA complexes to guide the design of nucleoside analogs for the position in the guide strand that contacts a conserved glutamic acid residue in ADARs (E488 in human ADAR2), which flips the adenosine into the ADAR active site for deamination.	Nucleosides	92-102	adenosine deaminase RNA specific B1	Homo sapiens	220-225
33939417-3	2021	Here we use structural information available for ADAR2-RNA complexes to guide the design of nucleoside analogs for the position in the guide strand that contacts a conserved glutamic acid residue in ADARs (E488 in human ADAR2), which flips the adenosine into the ADAR active site for deamination.	Nucleosides	92-102	adenosine deaminase RNA specific	Homo sapiens	49-53
33841878-1	2021	Background: Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-COV2) depends on RNA-dependent RNA polymerase (RdRp) enzyme complex for its genomic replications and thus can be inhibited by nucleoside analogues.	Nucleosides	192-202	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	113-117
33533561-2	2021	Bi-allelic TYMP mutations lead to deficient thymidine phosphorylase (TP) activity, toxic accumulation of plasma nucleosides (thymidine and deoxyuridine), nucleotide pool imbalances, and mitochondrial DNA (mtDNA) instability.	Nucleosides	112-123	thymidine phosphorylase	Homo sapiens	11-15
33556871-4	2021	The present article provides an overview of these small-molecule therapeutics based on insights from medicinal chemistry research and focuses on RNA-dependent RNA polymerase (RdRp) inhibitors, such as the nucleoside analogues remdesivir, favipiravir and ribavirin.	Nucleosides	205-215	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	175-179
33621788-0	2021	Elevated levels of oxidized nucleosides in individuals with the JAK2V617F mutation from a general population study.	Nucleosides	28-39	Janus kinase 2	Homo sapiens	64-68
32991685-1	2021	Adenosine is an endogenous nucleoside that plays a major role in the physiology and physiopathology of the coronary artery system, mainly by activating its A2A receptors (A2AR).	Nucleosides	27-37	adenosine A2a receptor	Homo sapiens	156-169
32991685-1	2021	Adenosine is an endogenous nucleoside that plays a major role in the physiology and physiopathology of the coronary artery system, mainly by activating its A2A receptors (A2AR).	Nucleosides	27-37	adenosine A2a receptor	Homo sapiens	171-175
33867522-0	2021	CPA-seq reveals small ncRNAs with methylated nucleosides and diverse termini.	Nucleosides	45-56	carboxypeptidase A1, pancreatic	Mus musculus	0-3
33867522-3	2021	Here we develop Cap-Clip acid pyrophosphatase (Cap-Clip), T4 polynucleotide kinase (PNK) and AlkB/AlkB(D135S)-facilitated small ncRNA sequencing (CPA-seq) to detect and quantify sRNAs with terminus multiplicities and nucleoside methylations.	Nucleosides	217-227	carboxypeptidase A1, pancreatic	Mus musculus	146-149
33867522-9	2021	CPA-seq is a powerful tool with high sensitivity and specificity for profiling sRNAs with methylated nucleosides and diverse termini.	Nucleosides	101-112	carboxypeptidase A1, pancreatic	Mus musculus	0-3
33727336-1	2021	The nucleoside adenosine accumulates extracellularly in solid tumors and inhibits CD8+ T cells by activating adenosine receptors.	Nucleosides	4-14	CD8a molecule	Homo sapiens	82-85
33544954-2	2021	ALKBH8 is a methyltransferase of the highly variable wobble nucleoside position in the anticodon loop of tRNA and thus plays a critical role in tRNA modification by preserving codon recognition and preventing errors in amino acid incorporation during translation.	Nucleosides	60-70	alkB homolog 8, tRNA methyltransferase	Homo sapiens	0-6
32770088-2	2021	Both are nucleoside analog pro-drugs processed by pyrimidine metabolism into a deoxynucleotide analog that depletes the key epigenetic regulator DNA methyltranseferase 1 (DNMT1).	Nucleosides	9-19	DNA methyltransferase 1	Homo sapiens	145-169
32770088-2	2021	Both are nucleoside analog pro-drugs processed by pyrimidine metabolism into a deoxynucleotide analog that depletes the key epigenetic regulator DNA methyltranseferase 1 (DNMT1).	Nucleosides	9-19	DNA methyltransferase 1	Homo sapiens	171-176
33715357-0	2021	Symmetric Nucleosides as Potent Purine Nucleoside Phosphorylase Inhibitors.	Nucleosides	10-21	purine nucleoside phosphorylase	Homo sapiens	32-63
33715357-4	2021	Here, we study the binding of human purine nucleoside phosphorylase (PNP) to some bidirectional symmetric nucleosides, a class of nucleoside analogues that are more flexible due to the absence of sugar pucker restraints.	Nucleosides	106-117	purine nucleoside phosphorylase	Homo sapiens	36-67
33715357-4	2021	Here, we study the binding of human purine nucleoside phosphorylase (PNP) to some bidirectional symmetric nucleosides, a class of nucleoside analogues that are more flexible due to the absence of sugar pucker restraints.	Nucleosides	106-117	purine nucleoside phosphorylase	Homo sapiens	69-72
33715357-4	2021	Here, we study the binding of human purine nucleoside phosphorylase (PNP) to some bidirectional symmetric nucleosides, a class of nucleoside analogues that are more flexible due to the absence of sugar pucker restraints.	Nucleosides	43-53	purine nucleoside phosphorylase	Homo sapiens	69-72
33715357-5	2021	We compared the binding energies of PNP-symmetric nucleosides to the binding energies of PNP-inosine/Imm-H (a transition-state analogue), by means of 200 ns long all-atom explicit-solvent Gaussian accelerated molecular dynamics simulations followed by energetics estimation using the MM-PBSA methodology.	Nucleosides	50-61	purine nucleoside phosphorylase	Homo sapiens	36-39
33715357-6	2021	Quite interestingly, we observed that a few symmetric nucleosides, namely, nu3 and nu4, showed strong binding with PNP (-14.1 and -12.6 kcal/mol, respectively), higher than inosine (-6.3 kcal/mol) and Imm-H (-9.6 kcal/mol).	Nucleosides	54-65	purine nucleoside phosphorylase	Homo sapiens	115-118
33655751-2	2021	Nucleoside analogs such as Remdesivir and beta-d-N4-hydroxycytidine are antiviral candidates and may function as chain terminators or induce viral mutations, thus impairing RdRp function.	Nucleosides	0-10	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	173-177
33655751-4	2021	To gain a structural understanding of the binding of this and several other nucleoside analogs in the precatalytic state, molecular models were developed that predict the noncovalent interactions to a complex of SARS-CoV-2 RdRp, RNA, and catalytic metal cations.	Nucleosides	76-86	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	223-227
33649228-8	2021	Finally, we show the proliferative defect in PPIP5K KO cells can be significantly rescued either by addition of inosine monophosphate or a nucleoside mixture or by stable expression of PPIP5K activity.	Nucleosides	139-149	inositol-pentakisphosphate 2-kinase	Homo sapiens	45-51
33755983-7	2021	Furthermore, we evidenced the ability of remdesivir, tenofovir, emtricitabine, and lamivudine to be incorporated in SARS-CoV-2 RdRp in the same protein pocket where poses the corresponding natural nucleoside substrates with comparable Ki and activating similar interactions.	Nucleosides	197-207	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	127-131
33472058-3	2021	In this study, we explored the physiological role of these extracellular modified nucleosides and found that N6-methyladenosine (m6A), widely recognized as an epigenetic mark in RNA, acts as a ligand for the human adenosine A3 receptor, for which it has greater affinity than unmodified adenosine.	Nucleosides	82-93	glycoprotein M6A	Homo sapiens	129-132
33472058-3	2021	In this study, we explored the physiological role of these extracellular modified nucleosides and found that N6-methyladenosine (m6A), widely recognized as an epigenetic mark in RNA, acts as a ligand for the human adenosine A3 receptor, for which it has greater affinity than unmodified adenosine.	Nucleosides	82-93	adenosine A3 receptor	Homo sapiens	214-235
32970317-1	2021	PURPOSE: Purine metabolism involves various intracellular and extracellular enzymes, including cN-II and CD73 that dephosphorylate intracellular and extracellular nucleoside monophosphates into their corresponding nucleosides.	Nucleosides	214-225	5'-nucleotidase, cytosolic II	Homo sapiens	95-100
32970317-1	2021	PURPOSE: Purine metabolism involves various intracellular and extracellular enzymes, including cN-II and CD73 that dephosphorylate intracellular and extracellular nucleoside monophosphates into their corresponding nucleosides.	Nucleosides	214-225	5'-nucleotidase ecto	Homo sapiens	105-109
33504774-2	2021	Here, we establish an efficient, safe, non-integrative method to transiently express hepatocyte-growth-factor (HGF) and epidermal-growth-factor (EGF) in hepatocytes via nucleoside-modified, lipid-nanoparticle-encapsulated mRNA (mRNA-LNP) delivery in mice.	Nucleosides	169-179	hepatocyte growth factor	Mus musculus	85-109
33494674-6	2021	The major drawbacks to DNMT1-targeted cancer therapy are the adverse effects arising from nucleoside and non-nucleoside based DNMT1 inhibitors.	Nucleosides	90-100	DNA methyltransferase 1	Homo sapiens	23-28
33494674-6	2021	The major drawbacks to DNMT1-targeted cancer therapy are the adverse effects arising from nucleoside and non-nucleoside based DNMT1 inhibitors.	Nucleosides	109-119	DNA methyltransferase 1	Homo sapiens	23-28
33316720-4	2021	It is learned that the introduction of the sterically hindered nucleoside at the specific position of siRNA, severely affects siRNA-RISC complex formation.	Nucleosides	63-73	serine carboxypeptidase 1	Homo sapiens	132-136
32827233-1	2021	A highly nucleobase discriminating metalated nucleoside analog, 3-fluoro-2-mercuri-6-methylaniline, was incorporated into an oligonucleotide molecular beacon.	Nucleosides	45-55	ubiquitin like 5	Homo sapiens	151-157
33452242-5	2021	In existing RNAs, we observe a time-dependent constant loss of modified nucleosides which is masked by post-transcriptional methylation mechanisms and thus undetectable without NAIL-MS. During alkylation stress, NAIL-MS reveals an adaptation of tRNA modifications in new transcripts but not existing ones.	Nucleosides	72-83	CD244 molecule	Homo sapiens	177-181
33452242-5	2021	In existing RNAs, we observe a time-dependent constant loss of modified nucleosides which is masked by post-transcriptional methylation mechanisms and thus undetectable without NAIL-MS. During alkylation stress, NAIL-MS reveals an adaptation of tRNA modifications in new transcripts but not existing ones.	Nucleosides	72-83	CD244 molecule	Homo sapiens	212-216
33430727-6	2021	In order to find compounds with better pharmacokinetic properties as DOT1L inhibitors, other types of non-nucleoside skeletons have also been reported successively.	Nucleosides	106-116	DOT1 like histone lysine methyltransferase	Homo sapiens	69-74
33435514-7	2021	Overall, our studies advance the understanding of requirements for nucleoside-derived inhibitors for SNM1A and indicate that groups containing a negatively charged group in close proximity to a metal chelator, such as hydroxamic acid malonates, are promising structures in the design of inhibitors.	Nucleosides	67-77	DNA cross-link repair 1A	Homo sapiens	101-106
33257873-0	2021	Cryptic phosphorylation in nucleoside natural product biosynthesis.	Nucleosides	27-37	cripto, FRL-1, cryptic family 1	Homo sapiens	0-7
33257873-3	2021	This phosphorylation is a unique cryptic modification as it is introduced in the third of seven steps during aminohexuronic acid (AHA) nucleoside biosynthesis, retained throughout the pathway"s duration, and is removed in the last step of the pathway.	Nucleosides	135-145	cripto, FRL-1, cryptic family 1	Homo sapiens	33-40
33257873-4	2021	Bioinformatic analysis of reported nucleoside biosynthetic gene clusters indicates the presence of cryptic phosphorylation in other pathways and the importance of functional characterization of kinases in nucleoside biosynthetic pathways in general.	Nucleosides	35-45	cripto, FRL-1, cryptic family 1	Homo sapiens	99-106
33075425-1	2021	Most nucleoside anticancer drugs show a primary resistance to p53-deficient or p53-mutated cancer cells and are limited in the clinic to the treatment of hematological malignancies.	Nucleosides	5-15	tumor protein p53	Homo sapiens	62-65
33075425-1	2021	Most nucleoside anticancer drugs show a primary resistance to p53-deficient or p53-mutated cancer cells and are limited in the clinic to the treatment of hematological malignancies.	Nucleosides	5-15	tumor protein p53	Homo sapiens	79-82
33504774-2	2021	Here, we establish an efficient, safe, non-integrative method to transiently express hepatocyte-growth-factor (HGF) and epidermal-growth-factor (EGF) in hepatocytes via nucleoside-modified, lipid-nanoparticle-encapsulated mRNA (mRNA-LNP) delivery in mice.	Nucleosides	169-179	epidermal growth factor	Mus musculus	120-143
33504774-2	2021	Here, we establish an efficient, safe, non-integrative method to transiently express hepatocyte-growth-factor (HGF) and epidermal-growth-factor (EGF) in hepatocytes via nucleoside-modified, lipid-nanoparticle-encapsulated mRNA (mRNA-LNP) delivery in mice.	Nucleosides	169-179	epidermal growth factor	Mus musculus	145-148
33504804-1	2021	The exonuclease activity of Apurinic/apyrimidinic endonuclease 1 (APE1) is responsible for processing matched/mismatched terminus in various DNA repair pathways and for removing nucleoside analogs associated with drug resistance.	Nucleosides	178-188	apurinic/apyrimidinic endonuclease 1	None	28-64
33504804-1	2021	The exonuclease activity of Apurinic/apyrimidinic endonuclease 1 (APE1) is responsible for processing matched/mismatched terminus in various DNA repair pathways and for removing nucleoside analogs associated with drug resistance.	Nucleosides	178-188	ape1	None	66-70
33504774-2	2021	Here, we establish an efficient, safe, non-integrative method to transiently express hepatocyte-growth-factor (HGF) and epidermal-growth-factor (EGF) in hepatocytes via nucleoside-modified, lipid-nanoparticle-encapsulated mRNA (mRNA-LNP) delivery in mice.	Nucleosides	169-179	hepatocyte growth factor	Mus musculus	111-114
33052071-9	2021	Chimeric CD39-CD73-ECD proteins were superior in converting triphosphate and diphosphate nucleotides into nucleosides when compared with ALP-ECD and HAP-ECD.	Nucleosides	106-117	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	9-13
33052071-9	2021	Chimeric CD39-CD73-ECD proteins were superior in converting triphosphate and diphosphate nucleotides into nucleosides when compared with ALP-ECD and HAP-ECD.	Nucleosides	106-117	5'-nucleotidase ecto	Homo sapiens	14-18
32633831-5	2021	In this review, we discuss the antiviral potential of RdRp inhibitors (mainly nucleoside analogs) with an aim to provide a comprehensive account of drug discovery on SARS-CoV-2.	Nucleosides	78-88	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	54-58
33290908-5	2021	We computationally screened a library of 190 triazole-modified nucleoside analogs for complementarity to the t1A-binding pocket of hAgo2.	Nucleosides	63-73	argonaute RISC catalytic component 2	Homo sapiens	131-136
33290908-8	2021	In particular, a triazole-modified nucleoside bearing an ester substituent imparted a nine-fold and five-fold increase in activity for both anti-miR21 and anti-miR122 at 300 and 5 nM, respectively.	Nucleosides	35-45	microRNA 21	Homo sapiens	145-150
33290908-8	2021	In particular, a triazole-modified nucleoside bearing an ester substituent imparted a nine-fold and five-fold increase in activity for both anti-miR21 and anti-miR122 at 300 and 5 nM, respectively.	Nucleosides	35-45	microRNA 122	Homo sapiens	160-166
33140501-2	2021	5-Fluorouracil (5-FU) is an anticancer nucleoside analog that both inhibits thymidylate synthase (TS) and causes DNA damage via the misincorporation of FdUTP and dUTP into DNA under the conditions of dTTP depletion.	Nucleosides	39-49	thymidylate synthetase	Homo sapiens	76-96
33328545-9	2020	Our work provided a nanomedicine platform for targeted co-delivery of nucleoside analog therapeutics and anthracycline anticancer drugs to achieve synergistic treatment of HER2+ cancer.	Nucleosides	70-80	erb-b2 receptor tyrosine kinase 2	Homo sapiens	172-176
34048668-2	2021	In the present study, the interaction of remdesivir and its nucleoside analog GS-441524 with OATP4C1 was evaluated to provide the detailed information about its renal handling.	Nucleosides	60-70	solute carrier organic anion transporter family member 4C1	Homo sapiens	93-100
33325691-2	2020	Removal of binding affinity to A3AR was achieved by 1"-homologation, and PPARgamma/delta dual modulation was derived from the structural similarity between the target nucleosides and PPAR modulator drug, rosiglitazone.	Nucleosides	167-178	peroxisome proliferator activated receptor gamma	Homo sapiens	73-88
33325691-2	2020	Removal of binding affinity to A3AR was achieved by 1"-homologation, and PPARgamma/delta dual modulation was derived from the structural similarity between the target nucleosides and PPAR modulator drug, rosiglitazone.	Nucleosides	167-178	peroxisome proliferator activated receptor alpha	Homo sapiens	73-77
33325691-3	2020	All the final nucleosides were devoid of AR-binding affinity and exhibited high binding affinities to PPARgamma/delta but lacked PPARalpha binding.	Nucleosides	14-25	peroxisome proliferator activated receptor gamma	Homo sapiens	102-117
33325691-3	2020	All the final nucleosides were devoid of AR-binding affinity and exhibited high binding affinities to PPARgamma/delta but lacked PPARalpha binding.	Nucleosides	14-25	peroxisome proliferator activated receptor alpha	Homo sapiens	129-138
32905795-8	2020	Adenine nucleotides and nucleosides fine tuning control adipogenesis and mature adipocytes function via the activation of P2 and P1 purinoceptors, respectively.	Nucleosides	24-35	pyrimidinergic receptor P2Y6	Homo sapiens	122-145
33298441-6	2020	Supplementing cells with nucleosides allows the completion of mitotic DNA synthesis, restraining Mus81-Eme1-dependent DNA damage in mitosis and the ensuing CIN.	Nucleosides	25-36	MUS81 structure-specific endonuclease subunit	Homo sapiens	97-102
33298441-6	2020	Supplementing cells with nucleosides allows the completion of mitotic DNA synthesis, restraining Mus81-Eme1-dependent DNA damage in mitosis and the ensuing CIN.	Nucleosides	25-36	essential meiotic structure-specific endonuclease 1	Homo sapiens	103-107
33196210-5	2020	Starting from novel spirocyclic intermediates, we exemplified the preparation of an undescribed class of carbocyclic nucleoside analogues and provided a proof of concept for application as inhibitors for the protein methyltransferase target PRMT5.	Nucleosides	117-127	protein arginine methyltransferase 5	Homo sapiens	241-246
33344638-2	2020	ENT2 mediates the uptake of purine and pyrimidine nucleosides and nucleobase besides transporting a variety of nucleoside-derived drugs, mostly in anticancer therapy.	Nucleosides	50-61	solute carrier family 29 member 2	Homo sapiens	0-4
33344638-2	2020	ENT2 mediates the uptake of purine and pyrimidine nucleosides and nucleobase besides transporting a variety of nucleoside-derived drugs, mostly in anticancer therapy.	Nucleosides	50-60	solute carrier family 29 member 2	Homo sapiens	0-4
33190694-0	2020	Non-typical nucleoside analogs as fluorescent and fluorogenic indicators of purine-nucleoside phosphorylase activity in biological samples.	Nucleosides	12-22	purine nucleoside phosphorylase	Homo sapiens	76-107
33039292-6	2020	RESULTS: Treatment of gemcitabine (nucleoside analogue anticancer agent) to pancreatic cancer (Panc-1, MiaPaca-2) and breast cancer (MDA-MB-231) cells amplified MDM-2 expression along with increase in EMT properties.	Nucleosides	35-45	MDM2 proto-oncogene	Homo sapiens	161-166
32999043-4	2020	Pharmacological blockade of AKT signaling with nucleoside analogue triciribine (TCN) in ZNF217+ orthotopically-injected OSA cell lines reduced tumor growth and metastasis.	Nucleosides	47-57	AKT serine/threonine kinase 1	Homo sapiens	28-31
32999043-4	2020	Pharmacological blockade of AKT signaling with nucleoside analogue triciribine (TCN) in ZNF217+ orthotopically-injected OSA cell lines reduced tumor growth and metastasis.	Nucleosides	47-57	zinc finger protein 217	Homo sapiens	88-94
32943628-6	2020	The coronavirus RdRp complex represents an Achilles heel for SARS-CoV, supporting nucleoside analogues as promising candidates for the treatment of COVID-19.	Nucleosides	82-92	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	16-20
33129204-8	2020	Furthermore, we demonstrate that the nucleoside metabolites of MRS2365 and 2-methylthio-ADP are adenosine receptor (AR) agonists, notably at A3 and A1ARs.	Nucleosides	37-47	ferredoxin reductase	Mus musculus	96-114
33129204-8	2020	Furthermore, we demonstrate that the nucleoside metabolites of MRS2365 and 2-methylthio-ADP are adenosine receptor (AR) agonists, notably at A3 and A1ARs.	Nucleosides	37-47	ferredoxin reductase	Mus musculus	116-118
33129204-9	2020	In vivo efficacy of MRS2365 in murine models of traumatic brain injury and stroke can be attributed to AR activation by its nucleoside metabolite AST-004, rather than P2Y1R activation.	Nucleosides	124-134	ferredoxin reductase	Mus musculus	103-105
33129204-10	2020	This research suggests the importance of reevaluation of previous in vitro and in vivo research of P2YRs and P2XRs as there is a potential that the pharmacology attributed to nucleotide agonists is due to AR activation by active nucleoside metabolites.	Nucleosides	229-239	ferredoxin reductase	Mus musculus	205-207
33262686-10	2020	Our study revealed that the genetic polymorphism of ADORA2A rs2298383 was associated with CE risk and predisposition to neurologic comorbidity in children with epilepsy, and the involved mechanism might be related to the regulation of neuron death and purine nucleoside biosynthesis.	Nucleosides	259-269	adenosine A2a receptor	Homo sapiens	52-59
33246973-3	2020	RESEARCH QUESTION: What is the impact of nucleosides in respiratory function in patients with TK2-deficient myopathy?	Nucleosides	41-52	thymidine kinase 2	Homo sapiens	94-97
33060576-1	2020	Toll-like receptor 7 (TLR7) recognizes both microbial and endogenous RNAs and nucleosides.	Nucleosides	78-89	toll-like receptor 7	Mus musculus	0-20
33060576-1	2020	Toll-like receptor 7 (TLR7) recognizes both microbial and endogenous RNAs and nucleosides.	Nucleosides	78-89	toll-like receptor 7	Mus musculus	22-26
33046037-13	2020	CONCLUSIONS: Three new nucleoside analogue-resistant HL-60 cell variants exhibited reduced production of intracellular analogue triphosphates and enhanced Bcl-2 and Mcl-1 expressions.	Nucleosides	23-33	BCL2 apoptosis regulator	Homo sapiens	155-160
33046037-13	2020	CONCLUSIONS: Three new nucleoside analogue-resistant HL-60 cell variants exhibited reduced production of intracellular analogue triphosphates and enhanced Bcl-2 and Mcl-1 expressions.	Nucleosides	23-33	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	165-170
32882127-0	2020	Bifunctional and unusual amino acid beta- or gamma-ester prodrugs of nucleoside analogues for improved affinity to ATB0,+ and enhanced metabolic stability: An application to floxuridine.	Nucleosides	69-79	solute carrier family 1 member 5	Homo sapiens	115-119
32882127-6	2020	The present study provided the first proof-of-concept of exploiting ATB0,+ for tumor-selective delivery of nucleoside analogues in the form of prodrug.	Nucleosides	107-117	solute carrier family 1 member 5	Homo sapiens	68-72
32777015-3	2020	We here show that Cx43 mediates gap-junctional coupling between collectively invading breast cancer cells and, via hemichannels, adenosine nucleotide/nucleoside release into the extracellular space.	Nucleosides	150-160	gap junction protein alpha 1	Homo sapiens	18-22
32743802-0	2020	e5NT inhibitor protects acute restraint stress-induced depression by regulating nucleoside release in mice.	Nucleosides	80-90	5' nucleotidase, ecto	Mus musculus	0-4
33142664-5	2020	As a hydrophilic nucleoside analogue, gemcitabine requires nucleoside transporters to permeate the plasma membrane, and a major role in the uptake of this drug is played by human equilibrative nucleoside transporter 1 (hENT-1).	Nucleosides	17-27	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	179-217
32875223-14	2020	The CNT3 protein, present in the microvilli of human vaginal epithelial cells, may have a role in redistributing nucleoside homologues delivered to the vaginal tract.	Nucleosides	113-123	solute carrier family 28 member 3	Homo sapiens	4-8
32159854-8	2020	The screen identified adefovir dipivoxil, a reverse transcriptase inhibitor and nucleoside analogue, as a compound that has increased cytotoxicity in the presence of ATR, but not ATM or DNA-PK inhibition.	Nucleosides	80-90	ATR serine/threonine kinase	Homo sapiens	166-169
32467171-9	2020	These results demonstrate that DRS induced by a nucleoside analog-type chemotherapeutic drug suppresses tumor growth irrespective of p53 status by directing tumor cell fate toward cellular senescence or apoptotic cell death according to p53 status.	Nucleosides	48-58	tumor protein p53	Homo sapiens	237-240
32973513-2	2020	The products are subsequently hydrolyzed by ecto-5"-nucleotidase (ecto-5"-NT) to nucleosides.	Nucleosides	81-92	5'-nucleotidase ecto	Homo sapiens	44-64
32875223-15	2020	Transporter proteins such as CNT3 could shuttle nucleosides and their analogs through the vaginal epithelium to immune cells located in lower cell layers.	Nucleosides	48-59	solute carrier family 28 member 3	Homo sapiens	29-33
32821086-10	2020	The nucleoside analog inhibits the viral RNA-dependent RNA polymerase (RdRp) by competing with the usual counterpart adenosine triphosphate (ATP).	Nucleosides	4-14	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	71-75
32784599-5	2020	Although these inhibitors, mainly nucleoside analogues such as 5-azacytidine (5-aza) and decitabine (DAC), cause re-expression of tumor suppressor genes, inhibition of tumor cell growth, and increased apoptosis in BC experimental models and clinical trials, they also show important drawbacks that prevent their use as a valuable option for the treatment of BC.	Nucleosides	34-44	arylacetamide deacetylase	Homo sapiens	101-104
32743071-0	2020	Cellular sensing of extracellular purine nucleosides triggers an innate IFN-beta response.	Nucleosides	41-52	IFN1@	Homo sapiens	72-80
32011735-9	2020	Adenosine deamination, inhibition of the ENT1 nucleoside outflow, and blockage of A1 receptors prevented PNU 282987-induced inhibition of transmitter release.	Nucleosides	46-56	solute carrier family 29 member 1	Rattus norvegicus	41-45
32823658-2	2020	New effective Tdp1 inhibitors were found in a series of nucleoside derivatives possessing 2",3",5"-tri-O-benzoyl-d-ribofuranose and 5-substituted uracil moieties and have half-maximal inhibitory concentrations (IC50) in the lower micromolar and submicromolar range.	Nucleosides	56-66	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	14-18
32556945-7	2020	Immortalized cells upregulated the CD39/NTPDase1 enzyme and downregulated CD73/NT5E and adenosine deaminase (ADA), which had a direct impact on their nucleotide/nucleoside metabolism profile.	Nucleosides	161-171	5'-nucleotidase ecto	Homo sapiens	79-83
32556945-7	2020	Immortalized cells upregulated the CD39/NTPDase1 enzyme and downregulated CD73/NT5E and adenosine deaminase (ADA), which had a direct impact on their nucleotide/nucleoside metabolism profile.	Nucleosides	161-171	adenosine deaminase	Homo sapiens	88-107
32556945-10	2020	Therefore, our data suggest that MSCs-TERT have altered expression of key enzymes of the extracellular nucleotides/nucleoside control, which altered key characteristics of these cells and can potentially change their therapeutic effects in tissue engineering in regenerative medicine.	Nucleosides	115-125	telomerase reverse transcriptase	Homo sapiens	38-42
32895153-11	2020	The target proteins of miR-30a-5p involved a wide range of biological processes, including signal transduction, intercellular communication, regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism.	Nucleosides	167-177	microRNA 30a	Homo sapiens	23-30
32743071-2	2020	Here, we identify a previously unidentified immune-metabolic axis by which cells respond to purine nucleosides and trigger a type I interferon-beta (IFN-beta) response.	Nucleosides	99-110	IFN1@	Homo sapiens	149-157
32743071-7	2020	We uncovered a previously unknown cellular signaling pathway that responds to extracellular DNA-derived metabolites, coupling nucleoside catabolism by adenosine deaminases to cellular IFN-beta production.	Nucleosides	126-136	IFN1@	Homo sapiens	184-192
32855848-2	2020	Lamivudine (3TC) is a nucleoside analog reverse transcriptase inhibitor known to inhibit the NLRP3 inflammasome.	Nucleosides	22-32	NLR family pyrin domain containing 3	Homo sapiens	93-98
32126230-1	2020	Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides.	Nucleosides	152-163	solute carrier family 28 member 1	Homo sapiens	109-116
32126230-1	2020	Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides.	Nucleosides	152-163	solute carrier family 28 member 1	Homo sapiens	109-114
32126230-1	2020	Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides.	Nucleosides	152-163	solute carrier family 28 member 2	Homo sapiens	195-200
32126230-1	2020	Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides.	Nucleosides	152-163	solute carrier family 28 member 3	Homo sapiens	248-253
32126230-1	2020	Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides.	Nucleosides	219-230	solute carrier family 28 member 1	Homo sapiens	109-116
32126230-1	2020	Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides.	Nucleosides	219-230	solute carrier family 28 member 1	Homo sapiens	109-114
32126230-1	2020	Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides.	Nucleosides	219-230	solute carrier family 28 member 2	Homo sapiens	195-200
32126230-1	2020	Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides.	Nucleosides	219-230	solute carrier family 28 member 3	Homo sapiens	248-253
32126230-1	2020	Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides.	Nucleosides	219-230	solute carrier family 28 member 1	Homo sapiens	109-116
32126230-1	2020	Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides.	Nucleosides	219-230	solute carrier family 28 member 1	Homo sapiens	109-114
32126230-1	2020	Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides.	Nucleosides	219-230	solute carrier family 28 member 2	Homo sapiens	195-200
32126230-1	2020	Humans possess three members of the cation-coupled concentrative nucleoside transporter CNT (SLC 28) family, hCNT1-3: hCNT1 is selective for pyrimidine nucleosides but also transports adenosine, hCNT2 transports purine nucleosides and uridine, and hCNT3 transports both pyrimidine and purine nucleosides.	Nucleosides	219-230	solute carrier family 28 member 3	Homo sapiens	248-253
32126230-2	2020	hCNT1/2 transport nucleosides using the transmembrane Na+ electrochemical gradient, while hCNT3 is both Na+- and H+-coupled.	Nucleosides	18-29	solute carrier family 28 member 1	Homo sapiens	0-7
32126230-3	2020	By producing recombinant hCNT3 in Xenopus laevis oocytes, we have used radiochemical high performance liquid chromatography (HPLC) analysis to investigate the metabolic fate of transported [3H] or [14C] pyrimidine and purine nucleosides once inside cells.	Nucleosides	225-236	solute carrier family 28 member 3	Homo sapiens	25-30
32126230-9	2020	Of these, hENT1 and hENT2 transport both nucleosides and nucleobases into and out of cells, but their relative contributions to nucleoside and nucleobase homeostasis and, in particular, to adenosine signaling via purinoreceptors, are not known.	Nucleosides	41-52	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	10-15
32126230-9	2020	Of these, hENT1 and hENT2 transport both nucleosides and nucleobases into and out of cells, but their relative contributions to nucleoside and nucleobase homeostasis and, in particular, to adenosine signaling via purinoreceptors, are not known.	Nucleosides	41-52	solute carrier family 29 member 2	Homo sapiens	20-25
32126230-9	2020	Of these, hENT1 and hENT2 transport both nucleosides and nucleobases into and out of cells, but their relative contributions to nucleoside and nucleobase homeostasis and, in particular, to adenosine signaling via purinoreceptors, are not known.	Nucleosides	41-51	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	10-15
32126230-9	2020	Of these, hENT1 and hENT2 transport both nucleosides and nucleobases into and out of cells, but their relative contributions to nucleoside and nucleobase homeostasis and, in particular, to adenosine signaling via purinoreceptors, are not known.	Nucleosides	41-51	solute carrier family 29 member 2	Homo sapiens	20-25
32428837-1	2020	Nucleoside analogs are subject to resistance mechanisms including downregulation of equilibrative nucleoside transporter (ENT1) and deoxycytidine kinase (dCK).	Nucleosides	0-10	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	122-126
32428837-1	2020	Nucleoside analogs are subject to resistance mechanisms including downregulation of equilibrative nucleoside transporter (ENT1) and deoxycytidine kinase (dCK).	Nucleosides	0-10	deoxycytidine kinase	Homo sapiens	132-152
32428837-1	2020	Nucleoside analogs are subject to resistance mechanisms including downregulation of equilibrative nucleoside transporter (ENT1) and deoxycytidine kinase (dCK).	Nucleosides	0-10	sticky	Drosophila melanogaster	154-157
32690026-1	2020	BACKGROUND: Deoxycytidine kinase (DCK), an enzyme in the nucleoside biosynthetic pathway, can affect the development of immune cells.	Nucleosides	57-67	deoxycytidine kinase	Homo sapiens	12-32
32690026-1	2020	BACKGROUND: Deoxycytidine kinase (DCK), an enzyme in the nucleoside biosynthetic pathway, can affect the development of immune cells.	Nucleosides	57-67	deoxycytidine kinase	Homo sapiens	34-37
32576829-4	2020	Furthermore, SAMHD1 sensitises cancer cells to nucleoside-analogue anti-cancer therapies and is linked with DNA repair and suppression of the interferon response to cytosolic nucleic acids.	Nucleosides	47-57	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	13-19
32587297-5	2020	The nucleoside analogs (DAC, 5AC and zebularine) were the most potent DHAs and increased the enzymatic activity of SIRT6 without showing any significant increase in other sirtuin isoforms.	Nucleosides	4-14	arylacetamide deacetylase	Homo sapiens	24-27
32587297-5	2020	The nucleoside analogs (DAC, 5AC and zebularine) were the most potent DHAs and increased the enzymatic activity of SIRT6 without showing any significant increase in other sirtuin isoforms.	Nucleosides	4-14	sirtuin 6	Homo sapiens	115-120
32587297-6	2020	ChIP-Seq analysis of bone marrow cells derived from six acute myeloid leukemia (AML) patients and treated with the nucleoside analog DAC induced genome-wide acetylation changes in H3K9, the physiological substrate for SIRT6.	Nucleosides	115-125	arylacetamide deacetylase	Homo sapiens	133-136
32587297-6	2020	ChIP-Seq analysis of bone marrow cells derived from six acute myeloid leukemia (AML) patients and treated with the nucleoside analog DAC induced genome-wide acetylation changes in H3K9, the physiological substrate for SIRT6.	Nucleosides	115-125	sirtuin 6	Homo sapiens	218-223
32587297-9	2020	To our knowledge, this is the first report to identify the nucleoside analogs DHAs as activators of SIRT6.	Nucleosides	59-69	sirtuin 6	Homo sapiens	100-105
32581304-3	2020	Here, data from pharmacogenomics studies and a panel of ALL cell lines reveal an inverse correlation between nelarabine sensitivity and the expression of SAMHD1, which can hydrolyse and inactivate triphosphorylated nucleoside analogues.	Nucleosides	215-225	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	154-160
32576829-7	2020	This precise molecular mechanism for SAMHD1 catalysis, reveals how SAMHD1 down-regulates cellular dNTP and modulates the efficacy of nucleoside-based anti-cancer and anti-viral therapies.	Nucleosides	133-143	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	37-43
32576829-7	2020	This precise molecular mechanism for SAMHD1 catalysis, reveals how SAMHD1 down-regulates cellular dNTP and modulates the efficacy of nucleoside-based anti-cancer and anti-viral therapies.	Nucleosides	133-143	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	67-73
32283108-3	2020	To date, the most promising broad-spectrum class of viral RdRp inhibitors are nucleoside analogues (NAs), with over 25 approved for the treatment of several medically important viral diseases.	Nucleosides	78-88	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	58-62
32421343-1	2020	We disclose a study on nucleoside triphosphate (NTP) analogues in which the gamma-phosphate is covalently modified by F8butwo different biodegradable masking units and d4T as nucleoside analogue that enable the delivery of d4TTP with high selectivity in phosphate buffer (pH 7.3) and by enzyme-triggered reactions in human CD4+ T-lymphocyte CEM cell extracts.	Nucleosides	23-33	CD4 molecule	Homo sapiens	323-326
32501800-4	2020	Here, we determined structures of Tribolium castaneum telomerase reverse transcriptase (TERT) throughout its catalytic cycle and mapped the active site residues responsible for nucleoside selection, metal coordination, triphosphate binding, and RNA template stabilization.	Nucleosides	177-187	telomerase reverse transcriptase	Tribolium castaneum	54-86
32501800-4	2020	Here, we determined structures of Tribolium castaneum telomerase reverse transcriptase (TERT) throughout its catalytic cycle and mapped the active site residues responsible for nucleoside selection, metal coordination, triphosphate binding, and RNA template stabilization.	Nucleosides	177-187	telomerase reverse transcriptase	Tribolium castaneum	88-92
32427989-7	2020	However, depleting Mdm4 sensitized p53-/- cells to the nucleoside analog gemcitabine, raising the future perspective of using Mdm4 inhibitors as chemosensitizers.	Nucleosides	55-65	MDM4 regulator of p53	Homo sapiens	19-23
32322913-1	2020	PURPOSE: Trifluridine (FTD) is the active component of the nucleoside chemotherapeutic drug trifluridine/tipiracil (FTD/TPI), which is approved worldwide for the treatment of patients with metastatic gastrointestinal cancer.	Nucleosides	59-69	triosephosphate isomerase 1	Homo sapiens	120-123
32417936-10	2020	Additionally, NE-siRNA CD73, TMZ or combined therapy decreased adenosine levels in liquor confirming the importance of this nucleoside on in vivo GB growth.	Nucleosides	124-134	5' nucleotidase, ecto	Rattus norvegicus	23-27
32253733-11	2020	Blocking LINE-1 with the nucleoside analog reverse-transcriptase inhibitor (NRTI) stavudine reduced infarction area, neuronal degeneration in the cerebral cortex, and reduced the expression of Bax and cleaved caspase 3.	Nucleosides	25-35	BCL2 associated X, apoptosis regulator	Rattus norvegicus	193-196
32253733-11	2020	Blocking LINE-1 with the nucleoside analog reverse-transcriptase inhibitor (NRTI) stavudine reduced infarction area, neuronal degeneration in the cerebral cortex, and reduced the expression of Bax and cleaved caspase 3.	Nucleosides	25-35	caspase 3	Rattus norvegicus	209-218
32427989-7	2020	However, depleting Mdm4 sensitized p53-/- cells to the nucleoside analog gemcitabine, raising the future perspective of using Mdm4 inhibitors as chemosensitizers.	Nucleosides	55-65	tumor protein p53	Homo sapiens	35-38
32271569-5	2020	These species-independent A3AR-selective nucleosides are low efficacy partial agonists and novel, nuanced modulators of the A3AR, a drug target of growing interest.	Nucleosides	41-52	adenosine A3 receptor	Mus musculus	26-30
32836709-12	2021	While nucleoside analogs compete with the natural substrate of RdRp, thereby terminating RNA replication, other compounds would physically block entry of the natural substrates into the active site.	Nucleosides	6-16	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	63-67
32523988-0	2020	Mre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication.	Nucleosides	57-67	MRE11 homolog, double strand break repair nuclease	Homo sapiens	0-5
32511380-6	2020	The coronavirus RdRp complex represents an Achilles heel for SARS-CoV, supporting nucleoside analogues as promising candidates for the treatment of COVID-19.	Nucleosides	82-92	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	16-20
32384746-1	2020	Adenosine is a nucleoside that impacts the cardiovascular system via the activation of its membrane receptors, named A1R, A2AR, A2BR and A3R.	Nucleosides	15-25	adenosine A2a receptor	Homo sapiens	122-126
32271569-5	2020	These species-independent A3AR-selective nucleosides are low efficacy partial agonists and novel, nuanced modulators of the A3AR, a drug target of growing interest.	Nucleosides	41-52	adenosine A3 receptor	Mus musculus	124-128
32059926-1	2020	Arf6 (ADP ribosylation factor 6), activated by Arf-GEF (guanine nucleoside exchange factor), is involved in the membrane trafficking and actin-remodeling which are critical for maintenance of cell organization and activity and for fusion of myoblasts to form myotubes/myofibers.	Nucleosides	56-74	ADP-ribosylation factor 6	Mus musculus	0-4
32145854-7	2020	The degree of linearity of the nucleosides was excellent (0.02-10 mug mL-1), and the detection and quantification limits were low (0.006-0.016 mug mL-1 and 0.02-0.05 mug mL-1, respectively).	Nucleosides	31-42	L1 cell adhesion molecule	Mus musculus	70-74
32059926-1	2020	Arf6 (ADP ribosylation factor 6), activated by Arf-GEF (guanine nucleoside exchange factor), is involved in the membrane trafficking and actin-remodeling which are critical for maintenance of cell organization and activity and for fusion of myoblasts to form myotubes/myofibers.	Nucleosides	56-74	ADP-ribosylation factor 6	Mus musculus	6-31
32062783-5	2020	The predictive value of the nucleoside diphosphate-linked moiety X motif 15 gene (NUDT15) has been studied in various diseases among different populations.	Nucleosides	28-50	nudix hydrolase 15	Homo sapiens	82-88
31377845-6	2020	Moreover, DCTPP1-deficient cells are highly sensitive to down-regulation of nucleoside salvage.	Nucleosides	76-86	dCTP pyrophosphatase 1	Homo sapiens	10-16
32134268-2	2020	Upon collisional activation, protonated ions of alkylated nucleosides frequently undergo facile neutral loss of a 2-deoxyribose in MS/MS, and further cleavage of the resulting protonated nucleobases in MS3 can sometimes be employed for differentiating regioisomeric alkylated DNA lesions.	Nucleosides	58-69	MS3	Homo sapiens	202-205
31944095-2	2020	Protein Nucleoside Phosphorylase (PNP) is an enzyme, which catalyzes reversible conversion process (ribosylation and phosphorolysis) between nucleobases (purines) and their nucleosides.	Nucleosides	173-184	purine nucleoside phosphorylase	Bos taurus	8-32
31944095-2	2020	Protein Nucleoside Phosphorylase (PNP) is an enzyme, which catalyzes reversible conversion process (ribosylation and phosphorolysis) between nucleobases (purines) and their nucleosides.	Nucleosides	173-184	purine nucleoside phosphorylase	Bos taurus	34-37
31909864-1	2020	4-Cyanoindole-2"-deoxyribonucleoside (4CIN) is a fluorescent isomorphic nucleoside analogue with superior spectroscopic properties in terms of Stokes shift and quantum yield in comparison to the widely utilized isomorphic nucleoside analogue, 2-aminopurine-2"-deoxyribonucleoside (2APN).	Nucleosides	26-36	pyridoxal phosphatase	Homo sapiens	39-42
31529730-4	2020	However, our recent findings that only acyclic nucleoside phosphonates (ANPs; adefovir dipivoxil and tenofovir disoproxil fumarate) had an additional effect of inducing interferon (IFN)-lambda3 in the gastrointestinal tract suggests that ANPs are not only distinct in their structures but also in their functions from nucleoside analogs (lamivudine and entecavir).	Nucleosides	47-57	interferon lambda 3	Homo sapiens	169-193
31736067-1	2020	The nucleoside analogue decitabine can deplete the epigenetic regulator DNA methyltransferase 1 (DNMT1), an effect that occurs, and is saturated at, low concentrations/doses.	Nucleosides	4-14	DNA methyltransferase 1	Homo sapiens	72-95
31736067-1	2020	The nucleoside analogue decitabine can deplete the epigenetic regulator DNA methyltransferase 1 (DNMT1), an effect that occurs, and is saturated at, low concentrations/doses.	Nucleosides	4-14	DNA methyltransferase 1	Homo sapiens	97-102
31909864-1	2020	4-Cyanoindole-2"-deoxyribonucleoside (4CIN) is a fluorescent isomorphic nucleoside analogue with superior spectroscopic properties in terms of Stokes shift and quantum yield in comparison to the widely utilized isomorphic nucleoside analogue, 2-aminopurine-2"-deoxyribonucleoside (2APN).	Nucleosides	72-82	pyridoxal phosphatase	Homo sapiens	39-42
31657548-3	2020	In this work, 100 ns molecular dynamics (MD) simulations, MM/GBSA binding free energy calculations, and conformational analysis were employed to propose a novel prospective anti-MUC1 aptamer with increased affinity towards the MUC1 epitope resulting from the double mutation of the T11 and T12 residues with PSU and U nucleosides, respectively.	Nucleosides	316-329	mucin 1, cell surface associated	Homo sapiens	178-182
31978781-0	2020	Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library.	Nucleosides	87-97	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	18-23
31978781-6	2020	Based on the developed DOT1L ligand binding model, a structure-based design strategy was applied and a second-generation of non-nucleoside DOT1L inhibitors was developed.	Nucleosides	128-138	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	23-28
31978781-6	2020	Based on the developed DOT1L ligand binding model, a structure-based design strategy was applied and a second-generation of non-nucleoside DOT1L inhibitors was developed.	Nucleosides	128-138	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	139-144
31978781-8	2020	These compounds represent novel chemical probes with a unique non-nucleoside scaffold that bind and compete with the SAM binding site of DOT1L, thus providing foundation for further medicinal chemistry efforts to develop more potent compounds.	Nucleosides	66-76	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	Mus musculus	137-142
31892080-4	2020	It was found that the Sil-ImCDs had good separation efficiency in the separation of bases, nucleosides, amino acids, saccharides and ginsenosides.	Nucleosides	91-102	STIL centriolar assembly protein	Homo sapiens	22-25
32003423-10	2020	Furthermore, functional enrichment analysis results suggested that ID1/2/4 were significantly enriched in "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" for biological process, "transcription factor activity" for molecular function and "HLH domain" for protein domain.	Nucleosides	133-143	inhibitor of DNA binding 1, HLH protein	Homo sapiens	67-74
32111063-1	2020	Purines are nitrogen compounds consisting mainly of a nitrogen base of adenine (ABP) or guanine (GBP) and their derivatives: nucleosides (nitrogen bases plus ribose) and nucleotides (nitrogen bases plus ribose and phosphate).	Nucleosides	125-136	amine oxidase copper containing 1	Homo sapiens	80-83
32111063-1	2020	Purines are nitrogen compounds consisting mainly of a nitrogen base of adenine (ABP) or guanine (GBP) and their derivatives: nucleosides (nitrogen bases plus ribose) and nucleotides (nitrogen bases plus ribose and phosphate).	Nucleosides	125-136	transmembrane protein 132A	Homo sapiens	97-100
31657548-3	2020	In this work, 100 ns molecular dynamics (MD) simulations, MM/GBSA binding free energy calculations, and conformational analysis were employed to propose a novel prospective anti-MUC1 aptamer with increased affinity towards the MUC1 epitope resulting from the double mutation of the T11 and T12 residues with PSU and U nucleosides, respectively.	Nucleosides	316-329	mucin 1, cell surface associated	Homo sapiens	227-231
32086630-1	2020	PURPOSE: S-(4-Nitrobenzyl)-6-thioinosine (NBMPR) is routinely used at concentrations of 0.10 muM and 0.10 mM to specifically inhibit transport of nucleosides mediated by equilibrative nucleoside transporters 1 (ENT1) and 2 (ENT2), respectively.	Nucleosides	146-157	solute carrier family 29 member 1	Rattus norvegicus	211-215
31994393-3	2020	In the case of adenosine, the selectivity of trifluoromethylation depends heavily on the functional group protection strategy and leads to a set of CF3 modified nucleosides with different substitution patterns (C-8, C-2, or both) in up to 37% yield.	Nucleosides	161-172	homeobox C8	Homo sapiens	211-214
31961887-8	2020	Gene Ontology (GO) enrichment analysis of these circRNA-host genes and microRNA (miRNA)-targeted genes indicated that these DE circRNAs were involved mainly in defense responses, ADP binding, nucleoside binding, organic substance catabolic processes, oxidoreductase activity, and signal transduction.	Nucleosides	192-202	putative NADH-dependent hydroxypyruvate reductase	Glycine max	251-265
31734178-4	2020	The JNK inhibitor JNK-IN-8 was found to potently inhibit nucleoside transport and engage ENT1.	Nucleosides	57-67	mitogen-activated protein kinase 8	Homo sapiens	4-7
31734178-4	2020	The JNK inhibitor JNK-IN-8 was found to potently inhibit nucleoside transport and engage ENT1.	Nucleosides	57-67	mitogen-activated protein kinase 8	Homo sapiens	18-21
31729766-8	2020	Finally, the unique chemical composition of the nucleoside analog was used to visualize the replication of damaged DNA in TdT-positive cells.	Nucleosides	48-58	DNA nucleotidylexotransferase	Homo sapiens	122-125
32080253-10	2020	Nucleoside analogues were prescribed in 28 (49.1%) anti-HBc-positive and the 2 HBsAg-positive patients.	Nucleosides	0-10	keratin 88, pseudogene	Homo sapiens	56-59
33062176-1	2020	A side-by-side pharmacological comparison of ribose and (N)-methanocarba (bicyclo[3.1.0]hexane) nucleosides as A3AR agonists indicated that the bicyclic pseudoribose ring constraint provided higher affinity/selectivity at human and mouse A3AR.	Nucleosides	96-107	adenosine A3 receptor	Homo sapiens	111-115
32103944-0	2020	Enhancing Antitumor Efficacy of Nucleoside Analog 5-Fluorodeoxyuridine on HER2-Overexpressing Breast Cancer by Affibody-Engineered DNA Nanoparticle.	Nucleosides	32-42	erb-b2 receptor tyrosine kinase 2	Homo sapiens	74-78
31915303-5	2020	We found that a recently developed influenza vaccine, nucleoside-modified mRNA encapsulated in lipid nanoparticles (mRNA-LNP), partially overcame this inhibition by maternal antibodies.	Nucleosides	54-64	lunapark, ER junction formation factor	Homo sapiens	121-124
31826808-3	2020	A strong effect of the boron cluster modification on the syn/anti equilibrium of the modified nucleosides was observed.	Nucleosides	94-105	synemin	Homo sapiens	57-60
31865252-4	2020	All final the new deprotected nucleosides were screened against leukemia 1210, and were found to be considerably less potent (Ic50% 1.4-10.6 muM) than doxorubicin (Ic50% 0.02 muM).	Nucleosides	30-41	latexin	Homo sapiens	141-144
31865252-4	2020	All final the new deprotected nucleosides were screened against leukemia 1210, and were found to be considerably less potent (Ic50% 1.4-10.6 muM) than doxorubicin (Ic50% 0.02 muM).	Nucleosides	30-41	latexin	Homo sapiens	175-178
31608988-2	2020	Recent structural analysis revealed that TLR7 has an additional binding site for nucleosides such as guanosine and is activated when both guanosine and ssRNA bind.	Nucleosides	81-92	toll like receptor 7	Homo sapiens	41-45
33020707-4	2020	In the present study, molecular recognition between the two natural nucleoside analogs (S-adenosyl-L-homocysteine (SAH) and sinefungin (SFG)) and the SARS-CoV-2 nsp16/nsp10/m7GpppAC5 was studied using all-atom molecular dynamics simulations and free energy calculations based on MM/GBSA and WaterSwap approaches.	Nucleosides	68-78	acyl-CoA synthetase medium chain family member 3	Homo sapiens	115-118
33020707-4	2020	In the present study, molecular recognition between the two natural nucleoside analogs (S-adenosyl-L-homocysteine (SAH) and sinefungin (SFG)) and the SARS-CoV-2 nsp16/nsp10/m7GpppAC5 was studied using all-atom molecular dynamics simulations and free energy calculations based on MM/GBSA and WaterSwap approaches.	Nucleosides	68-78	ORF1a polyprotein;ORF1ab polyprotein	Severe acute respiratory syndrome coronavirus 2	167-172
31808036-2	2020	Here we report the effects of a large set of common buffering agents, aminoacids and nucleoside phosphates over the amylin amyloid aggregation.	Nucleosides	85-106	islet amyloid polypeptide	Homo sapiens	116-122
31608988-3	2020	The nucleoside binding site also accommodates imidazoquinoline derivatives such as R848, which activates TLR7 in the absence of ssRNA.	Nucleosides	4-14	toll like receptor 7	Homo sapiens	105-109
32189555-0	2020	The expression and activity of thymidine kinase 1 and deoxycytidine kinase are modulated by hydrogen peroxide and nucleoside analogs.	Nucleosides	114-124	thymidine kinase 1	Homo sapiens	31-49
31646478-1	2020	Purinergic signaling involves extracellular purines and pyrimidines acting upon specific cell surface purinoceptors classified into the P1, P2X, and P2Y families for nucleosides and nucleotides.	Nucleosides	166-177	zinc finger protein 185	Mus musculus	136-143
32189555-0	2020	The expression and activity of thymidine kinase 1 and deoxycytidine kinase are modulated by hydrogen peroxide and nucleoside analogs.	Nucleosides	114-124	deoxycytidine kinase	Homo sapiens	54-74
32189555-3	2020	Here, we investigated the effects of oxidative stress and nucleoside analog on the expression and activity of TK1 and dCK.	Nucleosides	58-68	thymidine kinase 1	Homo sapiens	110-113
32189555-3	2020	Here, we investigated the effects of oxidative stress and nucleoside analog on the expression and activity of TK1 and dCK.	Nucleosides	58-68	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	118-121
31778791-2	2020	This study addressed the possibility of FLT3 modulating nucleoside salvage processes and, eventually, cytarabine action.	Nucleosides	56-66	fms related receptor tyrosine kinase 3	Homo sapiens	40-44
31778791-6	2020	Indeed, inhibition of cN-II with anthraquinone-2,6-disulfonic acid (AdiS) further potentiated the synergistic action of AC220 and cytarabine, at low concentrations of this nucleoside analog.	Nucleosides	172-182	5'-nucleotidase, cytosolic II	Homo sapiens	22-27
31778791-8	2020	Thus, inhibition of FLT3 may also target the biochemical machinery associated with nucleoside salvage, which may modulate the ability of nucleoside-derived drugs.	Nucleosides	83-93	fms related receptor tyrosine kinase 3	Homo sapiens	20-24
31778791-8	2020	Thus, inhibition of FLT3 may also target the biochemical machinery associated with nucleoside salvage, which may modulate the ability of nucleoside-derived drugs.	Nucleosides	137-147	fms related receptor tyrosine kinase 3	Homo sapiens	20-24
31874997-6	2019	A subgroup analysis of patients treated with regimens based on nucleoside analogs suggested that patients with negative brush border staining or apical localization of SLC22A3 in tumor cells have worse overall survival.	Nucleosides	63-73	solute carrier family 22 member 3	Homo sapiens	168-175
31752123-3	2019	Gemcitabine uptake into tumor cells is mainly through the human equilibrative nucleoside transport 1 (hENT1).	Nucleosides	78-88	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	102-107
32189555-11	2020	In conclusion TK1 and dCK expression and activity are apparently affected by oxidative stress and treatment by nucleoside analogs.	Nucleosides	111-121	thymidine kinase 1	Homo sapiens	14-17
32189555-11	2020	In conclusion TK1 and dCK expression and activity are apparently affected by oxidative stress and treatment by nucleoside analogs.	Nucleosides	111-121	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
31601121-11	2019	Higher hENT1 expression in MDA-MB231 seems to drive nucleoside transport, whereas TK1 expression in MCF7 seems responsible for comparable [18F]FLT retention in ER+ tumors.	Nucleosides	52-62	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	7-12
31730149-1	2019	ForI is a PLP-dependent enzyme from the biosynthetic pathway of the C-nucleoside antibiotic formycin.	Nucleosides	68-80	proteolipid protein 1	Homo sapiens	10-13
31798961-0	2019	Global alteration of T-lymphocyte metabolism by PD-L1 checkpoint involves a block of de novo nucleoside phosphate synthesis.	Nucleosides	93-113	CD274 molecule	Homo sapiens	48-53
30903745-1	2019	A recombinant deoxyribonucleoside kinase from Drosophila melanogaster with a deletion of the last 20 amino acid residues (named DmdNKDeltaC20) was hypothesized as a potential therapeutic tool for gene therapy due to its broad substrate specificity and better catalytic efficiency towards nucleosides and nucleoside analogs.	Nucleosides	288-299	deoxyribonucleoside kinase	Drosophila melanogaster	14-40
31704958-0	2019	Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta.	Nucleosides	52-62	DNA polymerase eta	Homo sapiens	103-121
31720371-2	2019	While hyper-methylation of histone H3 catalyzed by disruptor of telomeric silencing 1-like (DOT1L), a specific methyltransferase for histone H3 at lysine residue 79 (H3K79), is reported as a potential target for TNBCs, early developed nucleoside-type DOT1L inhibitors are not sufficient for effective inhibition of growth and metastasis of TNBC cells.	Nucleosides	235-245	DOT1 like histone lysine methyltransferase	Homo sapiens	92-97
31552932-3	2019	As a hypermodified base in which a nucleoside is covalently connected to an amino acid, acp3U is a natural nucleoside between genotype and phenotype and hence is also of particular importance for theories about the origin of life.	Nucleosides	35-45	acid phosphatase 3	Homo sapiens	88-92
31552932-3	2019	As a hypermodified base in which a nucleoside is covalently connected to an amino acid, acp3U is a natural nucleoside between genotype and phenotype and hence is also of particular importance for theories about the origin of life.	Nucleosides	107-117	acid phosphatase 3	Homo sapiens	88-92
31637926-0	2019	Novel nucleosides as potential inhibitors of fungal lanosterol 14alpha-demethylase: an in vitro and in silico study.	Nucleosides	6-17	cytochrome P450 family 51 subfamily A member 1	Homo sapiens	52-82
31199869-2	2019	TDP1 also removes DNA 3" end blocking lesions generated by chain-terminating nucleosides and alkylating agents, and base oxidation both in the nuclear and mitochondrial genomes.	Nucleosides	77-88	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	0-4
31444271-3	2019	In this study, using a CRISPR/Cas9-edited cell-based model, we show that the genetic or functional loss of RECQ1 sensitizes MDA-MB-231 breast cancer cells to gemcitabine, a nucleoside analog used in chemotherapy for triple-negative breast cancer.	Nucleosides	173-183	RecQ like helicase	Homo sapiens	107-112
31636477-2	2019	Although nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) variants significantly improve the predictive sensitivity of TIL, more than 50% of cases of this toxicity cannot be predicted by this mutation.	Nucleosides	9-31	nudix hydrolase 15	Homo sapiens	63-69
31720371-2	2019	While hyper-methylation of histone H3 catalyzed by disruptor of telomeric silencing 1-like (DOT1L), a specific methyltransferase for histone H3 at lysine residue 79 (H3K79), is reported as a potential target for TNBCs, early developed nucleoside-type DOT1L inhibitors are not sufficient for effective inhibition of growth and metastasis of TNBC cells.	Nucleosides	235-245	DOT1 like histone lysine methyltransferase	Homo sapiens	251-256
31575908-5	2019	Thus, loss of CD98hc triggers a dramatic reduction in the nucleotide pool, which leads to replicative stress in these cells, as evidenced by the enhanced DNA Damage Response (DDR), S-phase delay and diminished rate of mitosis, all recovered by nucleoside supplementation.	Nucleosides	244-254	solute carrier family 3 member 2	Homo sapiens	14-20
31420268-7	2019	Notably, our screen yielded non-competitive UCK2 inhibitors which were able to suppress nucleoside salvage in cells both in the presence and absence of DHODH inhibitors.	Nucleosides	88-98	uridine-cytidine kinase 2	Homo sapiens	44-48
31551431-0	2019	Label-free detection of transporter activity via GPCR signalling in living cells: A case for SLC29A1, the equilibrative nucleoside transporter 1.	Nucleosides	120-130	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	93-100
31380542-1	2019	Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A.	Nucleosides	14-25	DNA cross-link repair 1A	Homo sapiens	147-152
31537831-3	2019	We examined the pH-sensitivity of nucleoside influx and efflux by hENT4 using a recombinant transfection model that lacks the confounding influences of other nucleoside transporters (PK15-NTD).	Nucleosides	34-44	solute carrier family 29 member 4	Homo sapiens	66-71
31537831-8	2019	Enhanced influx and efflux of nucleosides by hENT4 under acidic conditions supports its potential as a therapeutic target in pathologies such as ischaemia-reperfusion injury.	Nucleosides	30-41	solute carrier family 29 member 4	Homo sapiens	45-50
31200235-6	2019	Along with the results of nucleoside protection assays, inhibition assays of dihydrofolate reductase (DHFR) clearly elucidated that the intracellular target of the designed compounds was DHFR.	Nucleosides	26-36	dihydrofolate reductase	Homo sapiens	187-191
30922852-5	2019	The nucleoside analogue ticagrelor and active metabolites of the thienopyridine compounds ticlopidine, clopidogrel and prasugrel inhibit platelet P2Y12 receptors and reduce thereby platelet aggregation.	Nucleosides	4-14	purinergic receptor P2Y12	Homo sapiens	146-151
31194978-4	2019	Its major effects involve the block of nucleoside uptake and phosphodiestesase inhibition, leading to increased levels of intracellular cAMP.	Nucleosides	39-49	cathelicidin antimicrobial peptide	Homo sapiens	136-140
30264323-2	2019	These nucleosides were evaluated for their anti-fibrotic renoprotective activity in TGF-beta1-treated murine proximal tubular (mProx) cells.	Nucleosides	6-17	transforming growth factor, beta 1	Mus musculus	84-93
31243956-4	2019	We observe six modified nucleosides with high confidence in highly purified mRNA samples (N7-methylguanosine, N6-methyladenosine, 2"-O-methylguanosine, 2"-O-methylcytidine, N4-acetylcytidine, and 5-formylcytidine) and identify the yeast protein responsible for N4-acetylcytidine incorporation in mRNAs (Rra1).	Nucleosides	24-35	ribosome biosynthesis protein KRE33	Saccharomyces cerevisiae S288C	303-307
30773117-0	2019	HSP90 inhibition depletes DNA repair proteins to sensitize acute myelogenous leukemia to nucleoside analog chemotherapeutics.	Nucleosides	89-99	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
31188623-2	2019	The actions of extracellular ATP are regulated through the catalytic functions extracellular nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), -2, -3, and -8, which ultimately generate nucleosides.	Nucleosides	192-203	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	93-137
31188623-2	2019	The actions of extracellular ATP are regulated through the catalytic functions extracellular nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), -2, -3, and -8, which ultimately generate nucleosides.	Nucleosides	192-203	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	139-147
31480444-3	2019	By incorporating the fluorescent nucleoside base analog 6-methylisoxanthopterin (6-MI) at or adjacent to a mismatch site to probe the structural and dynamic elements of the mismatch, we address how Msh2-Msh6 recognizes these mismatches for repair within the context of matched DNA.	Nucleosides	33-43	mismatch repair ATPase MSH2	Saccharomyces cerevisiae S288C	198-202
31322157-6	2019	Notably, it was also the best result among all modified non-phosphate acidic nucleosides reported and screened so far as RNase A inhibitors.	Nucleosides	77-88	ribonuclease A family member 1, pancreatic	Homo sapiens	121-128
31005290-11	2019	For the least retained nucleoside (uridine) a limit of detection of 50 ng mL-1 was estimated.	Nucleosides	23-33	L1 cell adhesion molecule	Mus musculus	74-78
30284504-5	2019	Mipomersen (ISIS 301012), which contains the novel nucleoside modification has been used to target to apolipoprotein (Apo B), which reduces LDL cholesterol by 6-41%.	Nucleosides	51-61	apolipoprotein B	Homo sapiens	118-123
30874985-8	2019	In contrast, those who develop HCC in the setting of chronic HBV infection, treatment with nucleoside analogues (NAs) is recommended prior to treating HCC, to prevent further liver injury and reduce the risk for HCC recurrence.	Nucleosides	91-101	HCC	Homo sapiens	31-34
31127007-9	2019	Thus, this study indicates that nucleoside derivatives can exhibit varied modulatory effects on P-gp activity, depending on structural functionalization.	Nucleosides	32-42	ATP binding cassette subfamily B member 1	Homo sapiens	96-100
31127007-14	2019	These results suggest that nucleoside derivatives, depending on structural functionalization, can modulate the function of P-gp.	Nucleosides	27-37	ATP binding cassette subfamily B member 1	Homo sapiens	123-127
31235912-1	2019	The human equilibrative nucleoside transporter 1 (hENT1), a member of the SLC29 family, plays crucial roles in adenosine signaling, cellular uptake of nucleoside for DNA and RNA synthesis, and nucleoside-derived anticancer and antiviral drug transport in humans.	Nucleosides	24-34	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	50-55
31235912-1	2019	The human equilibrative nucleoside transporter 1 (hENT1), a member of the SLC29 family, plays crucial roles in adenosine signaling, cellular uptake of nucleoside for DNA and RNA synthesis, and nucleoside-derived anticancer and antiviral drug transport in humans.	Nucleosides	151-161	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	10-48
31235912-1	2019	The human equilibrative nucleoside transporter 1 (hENT1), a member of the SLC29 family, plays crucial roles in adenosine signaling, cellular uptake of nucleoside for DNA and RNA synthesis, and nucleoside-derived anticancer and antiviral drug transport in humans.	Nucleosides	151-161	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	50-55
31235912-6	2019	Our studies provide a platform for improved pharmacological intervention of adenosine and nucleoside analog drug transport by hENT1.	Nucleosides	90-100	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	126-131
30850237-3	2019	Adenosine is an endogenous nucleoside that affects both coronary and limb artery blood flow, mostly via the adenosine A2A receptor (A2AR).	Nucleosides	27-37	adenosine A2a receptor	Homo sapiens	108-130
30850237-3	2019	Adenosine is an endogenous nucleoside that affects both coronary and limb artery blood flow, mostly via the adenosine A2A receptor (A2AR).	Nucleosides	27-37	adenosine A2a receptor	Homo sapiens	132-136
30701582-1	2019	AIMS: Cytidine deaminase (CDA) activity in cancer patients" serum has been proposed as a predictive biomarker for efficacy and toxicity of nucleoside analogues.	Nucleosides	139-149	cytidine deaminase	Homo sapiens	6-24
30701582-1	2019	AIMS: Cytidine deaminase (CDA) activity in cancer patients" serum has been proposed as a predictive biomarker for efficacy and toxicity of nucleoside analogues.	Nucleosides	139-149	cytidine deaminase	Homo sapiens	26-29
31123897-5	2019	The extracellular levels of nucleotides and nucleosides are regulated by the ectonucleotidases, such as the nucleoside triphosphate diphosphohydrolase 2 (NTPDase2).	Nucleosides	44-55	ectonucleoside triphosphate diphosphohydrolase 2	Homo sapiens	108-152
31123897-5	2019	The extracellular levels of nucleotides and nucleosides are regulated by the ectonucleotidases, such as the nucleoside triphosphate diphosphohydrolase 2 (NTPDase2).	Nucleosides	44-55	ectonucleoside triphosphate diphosphohydrolase 2	Homo sapiens	154-162
30798051-1	2019	The development of cytosolic 5"-nucleotidase II (cN-II) inhibitors is essential to validate cN-II as a potential target for the reversion of resistance to cytotoxic nucleoside analogues.	Nucleosides	165-175	5'-nucleotidase, cytosolic II	Homo sapiens	19-47
30798051-1	2019	The development of cytosolic 5"-nucleotidase II (cN-II) inhibitors is essential to validate cN-II as a potential target for the reversion of resistance to cytotoxic nucleoside analogues.	Nucleosides	165-175	5'-nucleotidase, cytosolic II	Homo sapiens	49-54
30798051-1	2019	The development of cytosolic 5"-nucleotidase II (cN-II) inhibitors is essential to validate cN-II as a potential target for the reversion of resistance to cytotoxic nucleoside analogues.	Nucleosides	165-175	5'-nucleotidase, cytosolic II	Homo sapiens	92-97
30805745-11	2019	Positive evidences are discussed about lamotrigine and ranolazine in non-dystrophic myotonias, chaperons in Pompe disease, and nucleosides in mitochondrial DNA depletion induced by thymidine kinase 2 deficiency.	Nucleosides	127-138	thymidine kinase 2	Homo sapiens	181-199
30696359-2	2019	Furthermore, TGF-beta1 can induce 5"-nucleotidase (CD73) expression in various cell types; this functional activity is associated with the production of adenosine (Ado), which is an immunosuppressive nucleoside.	Nucleosides	200-210	transforming growth factor beta 1	Homo sapiens	13-22
30535046-10	2019	Nucleoside metabolism might impact TLR8 responses in a variety of situations such as the treatment with nucleoside analogues.	Nucleosides	0-10	toll like receptor 8	Homo sapiens	35-39
30535046-10	2019	Nucleoside metabolism might impact TLR8 responses in a variety of situations such as the treatment with nucleoside analogues.	Nucleosides	104-114	toll like receptor 8	Homo sapiens	35-39
30290238-4	2019	For example, APOBEC3G deaminates cytosines to hypermutate reverse transcribed viral DNA; IFITM3 alters membranes to inhibit virus membrane fusion; MXA/B oligomerize on viral protein complexes to inhibit virus replication; SAMHD1 decreases dNTP intracellular concentrations to prevent reverse transcription of retrovirus genomes; tetherin prevents release of budding virions from cells; Viperin catalyzes formation of a nucleoside analogue that inhibits viral RNA polymerases; and ZAP binds virus RNAs to target them for degradation.	Nucleosides	419-429	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	13-21
30290238-4	2019	For example, APOBEC3G deaminates cytosines to hypermutate reverse transcribed viral DNA; IFITM3 alters membranes to inhibit virus membrane fusion; MXA/B oligomerize on viral protein complexes to inhibit virus replication; SAMHD1 decreases dNTP intracellular concentrations to prevent reverse transcription of retrovirus genomes; tetherin prevents release of budding virions from cells; Viperin catalyzes formation of a nucleoside analogue that inhibits viral RNA polymerases; and ZAP binds virus RNAs to target them for degradation.	Nucleosides	419-429	interferon induced transmembrane protein 3	Homo sapiens	89-95
30290238-4	2019	For example, APOBEC3G deaminates cytosines to hypermutate reverse transcribed viral DNA; IFITM3 alters membranes to inhibit virus membrane fusion; MXA/B oligomerize on viral protein complexes to inhibit virus replication; SAMHD1 decreases dNTP intracellular concentrations to prevent reverse transcription of retrovirus genomes; tetherin prevents release of budding virions from cells; Viperin catalyzes formation of a nucleoside analogue that inhibits viral RNA polymerases; and ZAP binds virus RNAs to target them for degradation.	Nucleosides	419-429	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	222-228
30290238-4	2019	For example, APOBEC3G deaminates cytosines to hypermutate reverse transcribed viral DNA; IFITM3 alters membranes to inhibit virus membrane fusion; MXA/B oligomerize on viral protein complexes to inhibit virus replication; SAMHD1 decreases dNTP intracellular concentrations to prevent reverse transcription of retrovirus genomes; tetherin prevents release of budding virions from cells; Viperin catalyzes formation of a nucleoside analogue that inhibits viral RNA polymerases; and ZAP binds virus RNAs to target them for degradation.	Nucleosides	419-429	bone marrow stromal cell antigen 2	Homo sapiens	329-337
30290238-4	2019	For example, APOBEC3G deaminates cytosines to hypermutate reverse transcribed viral DNA; IFITM3 alters membranes to inhibit virus membrane fusion; MXA/B oligomerize on viral protein complexes to inhibit virus replication; SAMHD1 decreases dNTP intracellular concentrations to prevent reverse transcription of retrovirus genomes; tetherin prevents release of budding virions from cells; Viperin catalyzes formation of a nucleoside analogue that inhibits viral RNA polymerases; and ZAP binds virus RNAs to target them for degradation.	Nucleosides	419-429	radical S-adenosyl methionine domain containing 2	Homo sapiens	386-393
30290238-4	2019	For example, APOBEC3G deaminates cytosines to hypermutate reverse transcribed viral DNA; IFITM3 alters membranes to inhibit virus membrane fusion; MXA/B oligomerize on viral protein complexes to inhibit virus replication; SAMHD1 decreases dNTP intracellular concentrations to prevent reverse transcription of retrovirus genomes; tetherin prevents release of budding virions from cells; Viperin catalyzes formation of a nucleoside analogue that inhibits viral RNA polymerases; and ZAP binds virus RNAs to target them for degradation.	Nucleosides	419-429	zinc finger CCCH-type containing, antiviral 1	Homo sapiens	480-483
31081638-3	2019	The key reaction sequence is a silyl-Hilbert-Johnson nucleosidation followed by Hartwig-Buchwald cross-coupling to achieve the N2-phenoxyacetyl protected c3G nucleoside.	Nucleosides	158-168	Rap guanine nucleotide exchange factor 1	Homo sapiens	154-157
30872078-4	2019	As the KCTD12-CDK1 interaction is necessary for CDK1 activation, we screened an FDA-approved drug library consisting of 616 compounds and identified that adefovir dipivoxil (AD), a nucleoside analog for treatment of HBV infections, disrupts the CDK1-KCTD12 interaction and induces G2 phase arrest in the cell cycle.	Nucleosides	181-191	potassium channel tetramerization domain containing 12	Homo sapiens	7-13
30872078-4	2019	As the KCTD12-CDK1 interaction is necessary for CDK1 activation, we screened an FDA-approved drug library consisting of 616 compounds and identified that adefovir dipivoxil (AD), a nucleoside analog for treatment of HBV infections, disrupts the CDK1-KCTD12 interaction and induces G2 phase arrest in the cell cycle.	Nucleosides	181-191	cyclin dependent kinase 1	Homo sapiens	14-18
31211245-2	2019	Its active metabolite, teriflunomide (Ter), directly inhibits dihydroorotate dehydrogenase (DHODH), an enzyme involved in nucleoside synthesis.	Nucleosides	122-132	dihydroorotate dehydrogenase (quinone)	Homo sapiens	62-90
31211245-2	2019	Its active metabolite, teriflunomide (Ter), directly inhibits dihydroorotate dehydrogenase (DHODH), an enzyme involved in nucleoside synthesis.	Nucleosides	122-132	dihydroorotate dehydrogenase (quinone)	Homo sapiens	92-97
30940660-1	2019	Deoxycytidine kinase (DCK) is a key enzyme for the activation of a broad spectrum of nucleoside-based chemotherapy drugs (e.g., gemcitabine); low DCK activity is one of the most important causes of cancer drug-resistance.	Nucleosides	85-95	deoxycytidine kinase	Mus musculus	0-20
30940660-1	2019	Deoxycytidine kinase (DCK) is a key enzyme for the activation of a broad spectrum of nucleoside-based chemotherapy drugs (e.g., gemcitabine); low DCK activity is one of the most important causes of cancer drug-resistance.	Nucleosides	85-95	deoxycytidine kinase	Mus musculus	22-25
30940660-1	2019	Deoxycytidine kinase (DCK) is a key enzyme for the activation of a broad spectrum of nucleoside-based chemotherapy drugs (e.g., gemcitabine); low DCK activity is one of the most important causes of cancer drug-resistance.	Nucleosides	85-95	deoxycytidine kinase	Mus musculus	146-149
30974332-3	2019	Here we characterize the immune responses induced by nucleoside-modified and purified mRNA-lipid nanoparticle (mRNA-LNP) vaccines encoding the clade C transmitted/founder HIV-1 envelope (Env) 1086C.	Nucleosides	53-63	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	187-190
30974332-4	2019	Intradermal vaccination with nucleoside-modified 1086C Env mRNA-LNPs elicited high levels of gp120-specific antibodies in rabbits and rhesus macaques.	Nucleosides	29-39	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	55-58
30959750-1	2019	Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an ultra-rare autosomal recessive disorder of nucleoside metabolism that is caused by mutations in the nuclear thymidine phosphorylase gene (TYMP) gene, encoding for the enzyme thymidine phosphorylase.	Nucleosides	111-121	thymidine phosphorylase	Homo sapiens	176-204
30817134-4	2019	Human MOCS3 is a dual-function protein that was shown to play an important role in Moco biosynthesis and in the mcm5s2U thio modifications of nucleosides in cytosolic tRNAs for Lys, Gln, and Glu.	Nucleosides	142-153	molybdenum cofactor synthesis 3	Homo sapiens	6-11
30024272-3	2019	It was hypothesized that the efficacy of mRNA CARs could be improved by utilizing recent advancements in RNA technology, such as incorporating a modified nucleoside, 1-methylpseudouridine, into the mRNA and applying a novel purification method using RNase III to eliminate dsRNA contaminants.	Nucleosides	154-164	cysteinyl-tRNA synthetase	Mus musculus	46-50
30428046-0	2019	Nucleoside supplementation modulates mitochondrial DNA copy number in the dguok -/- zebrafish.	Nucleosides	0-10	deoxyguanosine kinase	Danio rerio	74-79
30428046-6	2019	However, in adult dguok-/- fish we detected a significant increase in liver mtDNA copy number when supplemented with both purine nucleosides.	Nucleosides	129-140	deoxyguanosine kinase	Homo sapiens	18-23
30648556-1	2019	Nucleoside analogue reverse transcriptase (RT) inhibitors (NRTIs) are major antiviral agents against hepatitis B virus (HBV) and human immunodeficiency virus type-1 (HIV-1).	Nucleosides	0-10	polymerase	Hepatitis B virus	20-41
30648556-1	2019	Nucleoside analogue reverse transcriptase (RT) inhibitors (NRTIs) are major antiviral agents against hepatitis B virus (HBV) and human immunodeficiency virus type-1 (HIV-1).	Nucleosides	0-10	polymerase	Hepatitis B virus	43-45
30648556-3	2019	Here, we created HIV-1 RT mutants containing HBV-mimicking sextuple or septuple amino acid substitutions at the nucleoside-binding site (N-site) and verified that these mutants retained the RT activity.	Nucleosides	112-122	polymerase	Hepatitis B virus	23-25
30770553-1	2019	Nucleoside analogs represent the backbone of several distinct chemotherapy regimens for acute myeloid leukemia (AML) and combination with tyrosine kinase inhibitors has improved survival of AML patients, including those harboring the poor-risk FLT3-ITD mutation.	Nucleosides	0-10	fms related receptor tyrosine kinase 3	Homo sapiens	244-248
30709769-1	2019	BACKGROUND: Cytosolic 5"-nucleotidase 1A (NT5C1A) dephosphorylates non-cyclic nucleoside monophosphates to produce nucleosides and inorganic phosphates.	Nucleosides	115-126	5'-nucleotidase, cytosolic IA	Homo sapiens	12-40
30709769-1	2019	BACKGROUND: Cytosolic 5"-nucleotidase 1A (NT5C1A) dephosphorylates non-cyclic nucleoside monophosphates to produce nucleosides and inorganic phosphates.	Nucleosides	115-126	5'-nucleotidase, cytosolic IA	Homo sapiens	42-48
30024272-4	2019	T cells electroporated with nucleoside-modified and purified mRNA encoding CD19 CAR showed an initial twofold increase in CAR surface expression, as well as a twofold improvement in cytotoxic killing of leukemia cells that persisted up to 5 days.	Nucleosides	28-38	CD19 antigen	Mus musculus	75-79
30024272-4	2019	T cells electroporated with nucleoside-modified and purified mRNA encoding CD19 CAR showed an initial twofold increase in CAR surface expression, as well as a twofold improvement in cytotoxic killing of leukemia cells that persisted up to 5 days.	Nucleosides	28-38	nuclear receptor subfamily 1, group I, member 3	Mus musculus	80-83
30024272-4	2019	T cells electroporated with nucleoside-modified and purified mRNA encoding CD19 CAR showed an initial twofold increase in CAR surface expression, as well as a twofold improvement in cytotoxic killing of leukemia cells that persisted up to 5 days.	Nucleosides	28-38	nuclear receptor subfamily 1, group I, member 3	Mus musculus	122-125
30685920-1	2019	Objective: To investigate the molecular mechanism of poor response of nucleoside and interferon therapy in some patients with chronic hepatitis B (CHB) and the negative regulatory factor of suppressor of cytokine signaling 3 (SOCS3) expression in the interferon-signaling pathway.	Nucleosides	70-80	suppressor of cytokine signaling 3	Homo sapiens	190-224
30685920-1	2019	Objective: To investigate the molecular mechanism of poor response of nucleoside and interferon therapy in some patients with chronic hepatitis B (CHB) and the negative regulatory factor of suppressor of cytokine signaling 3 (SOCS3) expression in the interferon-signaling pathway.	Nucleosides	70-80	suppressor of cytokine signaling 3	Homo sapiens	226-231
30685920-2	2019	Also, study the clinical relationship between SOCS3 and antiviral efficacy of nucleoside and interferon.	Nucleosides	78-88	suppressor of cytokine signaling 3	Homo sapiens	46-51
30262060-5	2019	Compared with previous reported poly(acrylic acid)-grafted silica (Sil-PAA) stationary phase, Sil-PIA possesses shorter retention time but similar or higher selectivity for the separation of most polar compounds such as bases, nucleosides, amino acids, and saccharides in hydrophilic interaction chromatography.	Nucleosides	227-238	STIL centriolar assembly protein	Homo sapiens	94-97
30539536-6	2019	We have developed a novel SGTC system based on viral vector-mediated delivery of an engineered variant of human deoxycytidine kinase (dCK), which is capable of phosphorylating uridine- and thymidine-based nucleoside analogues that are not substrates for wild-type dCK, such as bromovinyl deoxyuridine (BVdU) and L-deoxythymidine (LdT).	Nucleosides	205-215	deoxycytidine kinase	Homo sapiens	112-132
30539536-6	2019	We have developed a novel SGTC system based on viral vector-mediated delivery of an engineered variant of human deoxycytidine kinase (dCK), which is capable of phosphorylating uridine- and thymidine-based nucleoside analogues that are not substrates for wild-type dCK, such as bromovinyl deoxyuridine (BVdU) and L-deoxythymidine (LdT).	Nucleosides	205-215	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	134-137
30539536-6	2019	We have developed a novel SGTC system based on viral vector-mediated delivery of an engineered variant of human deoxycytidine kinase (dCK), which is capable of phosphorylating uridine- and thymidine-based nucleoside analogues that are not substrates for wild-type dCK, such as bromovinyl deoxyuridine (BVdU) and L-deoxythymidine (LdT).	Nucleosides	205-215	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	264-267
30465822-4	2019	The extracellular actuation by surface CD20 crosslinking boosts robust activations of numerous intracellular responses, and promotes cancer cell susceptibility to various anticancer drugs, including docetaxel (microtubule stabilizer), gemcitabine (nucleoside analogue) and GDC-0980 (PI3K/mTOR inhibitor).	Nucleosides	248-258	keratin 20	Homo sapiens	39-43
30528800-1	2019	Human equilibrative nucleoside transporter 1 (hENT-1) is a membrane nucleoside transporter mediating the intracellular uptake of nucleosides and their analogues.	Nucleosides	129-140	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	6-44
30528800-1	2019	Human equilibrative nucleoside transporter 1 (hENT-1) is a membrane nucleoside transporter mediating the intracellular uptake of nucleosides and their analogues.	Nucleosides	129-140	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-52
31016706-2	2019	This chapter describes the application of an artificial nucleoside/nucleotide system that functions as a biochemical probe to quantify TLS activity under in vitro and in vivo conditions.	Nucleosides	56-66	FUS RNA binding protein	Homo sapiens	135-138
31016706-6	2019	The corresponding nucleoside, 3-Eth-5-NIdR, can be used to monitor TLS activity in hematological and adherent cancer cells treated with compounds that produce noninstructional DNA lesions.	Nucleosides	18-28	FUS RNA binding protein	Homo sapiens	67-70
30262060-5	2019	Compared with previous reported poly(acrylic acid)-grafted silica (Sil-PAA) stationary phase, Sil-PIA possesses shorter retention time but similar or higher selectivity for the separation of most polar compounds such as bases, nucleosides, amino acids, and saccharides in hydrophilic interaction chromatography.	Nucleosides	227-238	RPTOR independent companion of MTOR complex 2	Homo sapiens	98-101
30336167-2	2018	Here, we conjugated nucleoside-modified mRNA-LNPs with antibodies (Abs) specific to vascular cell adhesion molecule, PECAM-1.	Nucleosides	20-30	platelet and endothelial cell adhesion molecule 1	Homo sapiens	117-124
30577491-6	2018	Due to their active links to the nucleoside modification, deregulation in the snoRNA expressions can cause multiple disorders in humans.	Nucleosides	33-43	small nucleolar RNA, C/D box 14E	Homo sapiens	78-84
29243556-0	2018	Preferences of AAA/AAG codon recognition by modified nucleosides, taum5s2U34 and t6A37 present in tRNALys.	Nucleosides	53-64	N-methylpurine DNA glycosylase	Homo sapiens	19-22
30230919-0	2018	Nucleosides block AICAR-stimulated activation of AMPK in skeletal muscle and cancer cells.	Nucleosides	0-11	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	49-53
30230919-8	2018	MEMalpha with nucleosides blocked AICAR-stimulated AMPK activation even in the presence of methotrexate, which normally markedly enhances AICAR action by reducing its intracellular clearance.	Nucleosides	14-25	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	51-55
30230919-10	2018	Our findings show that nucleoside-containing media, commonly used in AMPK research, block action of the most widely used pharmacological AMPK activator AICAR.	Nucleosides	23-33	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	69-73
30230919-10	2018	Our findings show that nucleoside-containing media, commonly used in AMPK research, block action of the most widely used pharmacological AMPK activator AICAR.	Nucleosides	23-33	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	137-141
29243556-2	2018	This modified nucleoside of mt tRNALys, recognizes AAA/AAG codons during protein biosynthesis process.	Nucleosides	14-24	N-methylpurine DNA glycosylase	Homo sapiens	55-58
30469356-7	2018	Overall, these data suggest that HepaRG cells may be useful for analyzing cellular pharmacokinetics of nucleoside-like drugs in human hepatic cells, especially of those handled by ENT1.	Nucleosides	103-113	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	180-184
30193624-6	2018	We found that the levels of 5-mdC, 5-hmdC, 5-mrC and 5-hmrC in urine were all substantially decreased in CRC patients, suggesting that these modified nucleosides might have great potential to be noninvasive biomarkers for early detection and prognosis of CRC.	Nucleosides	150-161	C-C motif chemokine ligand 22	Homo sapiens	30-33
30187948-5	2018	In the current study we aim to determine the toxicity of nucleoside or nucleotide and nonnucleoside reverse-transcriptase inhibitors, Duovir and Viraday on liver mitochondria isolated from treated mice by monitoring UCP2 expression.	Nucleosides	57-67	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	216-220
30254099-1	2018	Human equilibrative nucleoside transporter 1 (hENT1), the first identified member of the ENT family of integral membrane proteins, is the primary mechanism for cellular uptake of physiologic nucleosides and many antineoplastic and antiviral nucleoside drugs.	Nucleosides	191-202	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	6-44
30076612-1	2018	BACKGROUND AND PURPOSE: The concentrative nucleoside transporter 2 (CNT2) mediates the uptake of both natural nucleosides and nucleoside-derived drugs.	Nucleosides	110-121	solute carrier family 28 member 2	Homo sapiens	28-66
30076612-1	2018	BACKGROUND AND PURPOSE: The concentrative nucleoside transporter 2 (CNT2) mediates the uptake of both natural nucleosides and nucleoside-derived drugs.	Nucleosides	110-121	solute carrier family 28 member 2	Homo sapiens	68-72
30076612-1	2018	BACKGROUND AND PURPOSE: The concentrative nucleoside transporter 2 (CNT2) mediates the uptake of both natural nucleosides and nucleoside-derived drugs.	Nucleosides	42-52	solute carrier family 28 member 2	Homo sapiens	68-72
30254099-1	2018	Human equilibrative nucleoside transporter 1 (hENT1), the first identified member of the ENT family of integral membrane proteins, is the primary mechanism for cellular uptake of physiologic nucleosides and many antineoplastic and antiviral nucleoside drugs.	Nucleosides	191-202	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
30254099-1	2018	Human equilibrative nucleoside transporter 1 (hENT1), the first identified member of the ENT family of integral membrane proteins, is the primary mechanism for cellular uptake of physiologic nucleosides and many antineoplastic and antiviral nucleoside drugs.	Nucleosides	20-30	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
30012570-6	2018	PGC and C18 matrices yielded excellent signal-to-noise ratios in nLC-MS while differing in the separation capability and sensitivity for various nucleosides.	Nucleosides	145-156	Bardet-Biedl syndrome 9	Homo sapiens	8-11
30373120-1	2018	Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE-MTDPS1) is a devastating autosomal recessive disorder due to mutations in TYMP, which cause a loss of function of thymidine phosphorylase (TP), nucleoside accumulation in plasma and tissues, and mitochondrial dysfunction.	Nucleosides	205-215	thymidine phosphorylase	Homo sapiens	55-67
30373120-1	2018	Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE-MTDPS1) is a devastating autosomal recessive disorder due to mutations in TYMP, which cause a loss of function of thymidine phosphorylase (TP), nucleoside accumulation in plasma and tissues, and mitochondrial dysfunction.	Nucleosides	205-215	thymidine phosphorylase	Homo sapiens	135-139
29866926-3	2018	Here, it is demonstrated that the human colorectal cancer cell line DLD1 with acquired resistance to trifluridine (FTD), a key component of the novel, orally administered nucleoside analogue-type chemotherapeutic drug trifluridine/tipiracil, lacks functional thymidine kinase 1 (TK1) expression because of one nonsense mutation in the coding exon.	Nucleosides	171-181	thymidine kinase 1	Homo sapiens	259-277
29866926-3	2018	Here, it is demonstrated that the human colorectal cancer cell line DLD1 with acquired resistance to trifluridine (FTD), a key component of the novel, orally administered nucleoside analogue-type chemotherapeutic drug trifluridine/tipiracil, lacks functional thymidine kinase 1 (TK1) expression because of one nonsense mutation in the coding exon.	Nucleosides	171-181	thymidine kinase 1	Homo sapiens	279-282
30143259-1	2018	Human equilibrative nucleoside transporter 1 (hENT1) transports nucleoside analogue drugs across cellular membranes and is necessary for the uptake of many anti-tumor drugs.	Nucleosides	20-30	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
30071207-7	2018	The expression of NT5E, an extracellular enzyme involved in formation of nucleosides, including uridine, was specifically knocked down in the dorsal striatum of mice using adeno-associated virus (AAV)-mediated short hairpin RNA (shRNA).	Nucleosides	73-84	5' nucleotidase, ecto	Mus musculus	18-22
30237706-8	2018	Moreover, the nucleosides elevated SIRT1 activation and suppressed nuclear factor-kappaB (NF-kappaB)/p65 activation in vitro and in vivo.	Nucleosides	14-25	sirtuin 1	Mus musculus	35-40
30237706-8	2018	Moreover, the nucleosides elevated SIRT1 activation and suppressed nuclear factor-kappaB (NF-kappaB)/p65 activation in vitro and in vivo.	Nucleosides	14-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-99
30237706-8	2018	Moreover, the nucleosides elevated SIRT1 activation and suppressed nuclear factor-kappaB (NF-kappaB)/p65 activation in vitro and in vivo.	Nucleosides	14-25	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	101-104
30237706-11	2018	Conclusion: These results show that the nucleosides suppressed COPD inflammation through the SIRT1-NF-kappaB/p65 pathway, suggesting that the nucleosides may be partly responsible for the therapeutic effects of cultured C. sinensis on COPD patients.	Nucleosides	40-51	sirtuin 1	Mus musculus	93-98
30237706-11	2018	Conclusion: These results show that the nucleosides suppressed COPD inflammation through the SIRT1-NF-kappaB/p65 pathway, suggesting that the nucleosides may be partly responsible for the therapeutic effects of cultured C. sinensis on COPD patients.	Nucleosides	40-51	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
30237706-11	2018	Conclusion: These results show that the nucleosides suppressed COPD inflammation through the SIRT1-NF-kappaB/p65 pathway, suggesting that the nucleosides may be partly responsible for the therapeutic effects of cultured C. sinensis on COPD patients.	Nucleosides	40-51	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	109-112
30237706-11	2018	Conclusion: These results show that the nucleosides suppressed COPD inflammation through the SIRT1-NF-kappaB/p65 pathway, suggesting that the nucleosides may be partly responsible for the therapeutic effects of cultured C. sinensis on COPD patients.	Nucleosides	142-153	sirtuin 1	Mus musculus	93-98
30237706-11	2018	Conclusion: These results show that the nucleosides suppressed COPD inflammation through the SIRT1-NF-kappaB/p65 pathway, suggesting that the nucleosides may be partly responsible for the therapeutic effects of cultured C. sinensis on COPD patients.	Nucleosides	142-153	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
30237706-11	2018	Conclusion: These results show that the nucleosides suppressed COPD inflammation through the SIRT1-NF-kappaB/p65 pathway, suggesting that the nucleosides may be partly responsible for the therapeutic effects of cultured C. sinensis on COPD patients.	Nucleosides	142-153	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	109-112
29963864-1	2018	We report the first syntheses of three nucleoside analogues, namely, 2",4"-diOMe-rU, 2"-OMe,4"-F-rU, and 2"-F,4"-OMe-araU, via stereoselective introduction of fluorine or methoxy functionalities at the C4"-alpha-position of a 4",5"-olefinic intermediate.	Nucleosides	39-49	complement C4A (Rodgers blood group)	Homo sapiens	202-211
30176535-0	2018	CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates.	Nucleosides	36-46	5'-nucleotidase ecto	Homo sapiens	0-4
29864673-3	2018	This activation occurred within hours after addition of the nucleosides and was primarily dependent on the ENT1 nucleoside transporter protein.	Nucleosides	60-71	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	107-111
29900657-5	2018	Recently, we reported the synthesis and properties of mechanism-based modified nucleosides, 2-amino-4-halopyridine-C-nucleosides (dX P), as inhibitors of DNMT.	Nucleosides	79-90	DNA methyltransferase 1	Homo sapiens	154-158
29900657-6	2018	To develop a more efficient inhibitor of DNMT for oligonucleotide therapeutics, oligodeoxyribonucleotides (ODNs) containing other nucleoside analogues, which react more quickly with DNMT, are needed.	Nucleosides	130-140	DNA methyltransferase 1	Homo sapiens	41-45
29900657-6	2018	To develop a more efficient inhibitor of DNMT for oligonucleotide therapeutics, oligodeoxyribonucleotides (ODNs) containing other nucleoside analogues, which react more quickly with DNMT, are needed.	Nucleosides	130-140	DNA methyltransferase 1	Homo sapiens	182-186
29990695-0	2018	Recovery of circulating CD56dim NK cells and the balance of Th17/Treg after nucleoside analog therapy in patients with chronic hepatitis B and low levels of HBsAg.	Nucleosides	76-86	neural cell adhesion molecule 1	Homo sapiens	24-28
30181772-2	2018	We aim to investigate whether CHB-related HCC patients receiving nucleoside analogue regimen or not have a different prognosis.	Nucleosides	65-75	HCC	Homo sapiens	42-45
29901093-11	2018	The cytotoxicity and bystander effects of Dm-dNK combined with cytotoxic nucleoside analogs were both observed in Dm-dNK+ keloid fibroblasts.	Nucleosides	73-83	deoxyribonucleoside kinase	Drosophila melanogaster	114-120
30237706-0	2018	Nucleosides isolated from Ophiocordyceps sinensis inhibit cigarette smoke extract-induced inflammation via the SIRT1-nuclear factor-kappaB/p65 pathway in RAW264.7 macrophages and in COPD mice.	Nucleosides	0-11	sirtuin 1	Mus musculus	111-116
30237706-0	2018	Nucleosides isolated from Ophiocordyceps sinensis inhibit cigarette smoke extract-induced inflammation via the SIRT1-nuclear factor-kappaB/p65 pathway in RAW264.7 macrophages and in COPD mice.	Nucleosides	0-11	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	139-142
29989830-0	2018	4-Cyanoindole-2"-deoxyribonucleoside (4CIN): A Universal Fluorescent Nucleoside Analogue.	Nucleosides	69-79	pyridoxal phosphatase	Homo sapiens	39-42
30237706-7	2018	Results: The nucleosides inhibited inflammatory mediator expression of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, and nitric oxide in both the CSE-stimulated RAW264.7 macrophages and mice.	Nucleosides	13-24	tumor necrosis factor	Mus musculus	71-98
30237706-7	2018	Results: The nucleosides inhibited inflammatory mediator expression of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, and nitric oxide in both the CSE-stimulated RAW264.7 macrophages and mice.	Nucleosides	13-24	interleukin 6	Mus musculus	100-113
30237706-7	2018	Results: The nucleosides inhibited inflammatory mediator expression of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, and nitric oxide in both the CSE-stimulated RAW264.7 macrophages and mice.	Nucleosides	13-24	interleukin 1 beta	Mus musculus	115-132
29989830-1	2018	The synthesis and characterization of a universal and fluorescent nucleoside, 4-cyanoindole-2"-deoxyribonucleoside (4CIN), and its incorporation into DNA is described.	Nucleosides	66-76	pyridoxal phosphatase	Homo sapiens	117-120
29752184-4	2018	To obtain insight into the reaction mechanism, we planned the incorporation of acyclic nucleosides, which make it easy to flip out the target nucleobase, into oligodeoxynucleotides (ODNs) and investigated the interaction between the ODN and DNMT.	Nucleosides	87-98	DNA methyltransferase 1	Homo sapiens	241-245
29862811-1	2018	The bacterial enzyme tRNA-guanine transglycosylase (TGT) is involved in the biosynthesis of queuosine, a modified nucleoside present in the anticodon wobble position of tRNAHis, tRNATyr, tRNAAsp, and tRNAAsn.	Nucleosides	114-124	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	21-50
29862811-1	2018	The bacterial enzyme tRNA-guanine transglycosylase (TGT) is involved in the biosynthesis of queuosine, a modified nucleoside present in the anticodon wobble position of tRNAHis, tRNATyr, tRNAAsp, and tRNAAsn.	Nucleosides	114-124	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	52-55
29559562-0	2018	Adjuvant Treatment for POLE Proofreading Domain-Mutant Cancers: Sensitivity to Radiotherapy, Chemotherapy, and Nucleoside Analogues.	Nucleosides	111-121	polymerase (DNA directed), epsilon	Mus musculus	23-27
29559562-7	2018	Conversely, POLE mutations result in hypersensitivity to nucleoside analogues, suggesting the use of these compounds as a potentially effective targeted treatment for advanced-stage POLE-mutant cancers.	Nucleosides	57-67	polymerase (DNA directed), epsilon	Mus musculus	12-16
29559562-7	2018	Conversely, POLE mutations result in hypersensitivity to nucleoside analogues, suggesting the use of these compounds as a potentially effective targeted treatment for advanced-stage POLE-mutant cancers.	Nucleosides	57-67	polymerase (DNA directed), epsilon	Mus musculus	182-186
29752943-6	2018	In conclusion, nucleoside and nucleotide analogues displayed different patterns of Notch signaling activity under HBV infection, and the induction of mTORC2-Akt (Ser473) phosphorylation may contribute to nucleotide analogues-mediated Notch signaling activation.	Nucleosides	15-25	CREB regulated transcription coactivator 2	Mus musculus	150-156
29752943-6	2018	In conclusion, nucleoside and nucleotide analogues displayed different patterns of Notch signaling activity under HBV infection, and the induction of mTORC2-Akt (Ser473) phosphorylation may contribute to nucleotide analogues-mediated Notch signaling activation.	Nucleosides	15-25	AKT serine/threonine kinase 1	Homo sapiens	157-160
29703734-4	2018	A polG mutant is capable of accumulating multiple intermediates, including the peptidyl moiety (carbamoylpolyoxamic acid [CPOAA]) and the nucleoside skeletons (POL-C and the previously overlooked thymine POL-C).	Nucleosides	138-148	DNA polymerase gamma, catalytic subunit	Homo sapiens	2-6
29703734-5	2018	We further demonstrate that PolG employs an ATP-dependent mechanism for amide bond formation and that the generation of the hybrid nucleoside antibiotic POL-N is also governed by PolG.	Nucleosides	131-141	DNA polymerase gamma, catalytic subunit	Homo sapiens	28-32
29703734-5	2018	We further demonstrate that PolG employs an ATP-dependent mechanism for amide bond formation and that the generation of the hybrid nucleoside antibiotic POL-N is also governed by PolG.	Nucleosides	131-141	DNA polymerase gamma, catalytic subunit	Homo sapiens	179-183
29928232-13	2018	In particular, the two new hENT2 isoforms recently described together with hENT2 seem to be key elements controlling nucleoside and nucleotide pools for DNA synthesis.	Nucleosides	117-127	solute carrier family 29 member 2	Homo sapiens	27-32
29899363-9	2018	Most strikingly, nucleosides were reduced upon Anks3 depletion, while 5-methyluridine and 6-methyladenosine accumulated over time.	Nucleosides	17-28	ankyrin repeat and sterile alpha motif domain containing 3	Mus musculus	47-52
29899363-12	2018	In combination, these results suggest that Anks3 may be involved in DNA damage responses by balancing the intracellular nucleoside pool.	Nucleosides	120-130	ankyrin repeat and sterile alpha motif domain containing 3	Mus musculus	43-48
29928232-13	2018	In particular, the two new hENT2 isoforms recently described together with hENT2 seem to be key elements controlling nucleoside and nucleotide pools for DNA synthesis.	Nucleosides	117-127	solute carrier family 29 member 2	Homo sapiens	75-80
29789314-0	2018	Inhibition of ATR acutely sensitizes acute myeloid leukemia cells to nucleoside analogs that target ribonucleotide reductase.	Nucleosides	69-79	ataxia telangiectasia and Rad3 related	Mus musculus	14-17
29429030-0	2018	Nucleoside Reverse Transcriptase Inhibitors (NRTIs) Induce Pathological Pain through Wnt5a-Mediated Neuroinflammation in Aging Mice.	Nucleosides	0-10	wingless-type MMTV integration site family, member 5A	Mus musculus	85-90
29789314-2	2018	Here we show that the antileukemic activity of the chemotherapeutic nucleoside analogs hydroxyurea and gemcitabine was significantly potentiated by ATR inhibition via a mechanism involving ribonucleotide reductase (RNR) abrogation and inhibition of replication fork progression.	Nucleosides	68-78	ataxia telangiectasia and Rad3 related	Mus musculus	148-151
29791845-5	2018	Our results identify ENT3 as a vital metabolite transporter that supports T cell homeostasis and activation by regulating lysosomal integrity and the availability of nucleosides.	Nucleosides	166-177	solute carrier family 29 member 3	Homo sapiens	21-25
29530865-6	2018	Transport analyses of hENT3-hENT1 chimeric constructs demonstrated that the N-terminal half of hENT3 is primarily responsible for the hENT3-3"-deoxy-nucleoside analog interaction.	Nucleosides	149-159	solute carrier family 29 member 3	Homo sapiens	22-27
29530865-6	2018	Transport analyses of hENT3-hENT1 chimeric constructs demonstrated that the N-terminal half of hENT3 is primarily responsible for the hENT3-3"-deoxy-nucleoside analog interaction.	Nucleosides	149-159	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	28-33
29530865-6	2018	Transport analyses of hENT3-hENT1 chimeric constructs demonstrated that the N-terminal half of hENT3 is primarily responsible for the hENT3-3"-deoxy-nucleoside analog interaction.	Nucleosides	149-159	solute carrier family 29 member 3	Homo sapiens	95-100
29530865-6	2018	Transport analyses of hENT3-hENT1 chimeric constructs demonstrated that the N-terminal half of hENT3 is primarily responsible for the hENT3-3"-deoxy-nucleoside analog interaction.	Nucleosides	149-159	solute carrier family 29 member 3	Homo sapiens	95-100
29530865-8	2018	The identification of the transporter segment and amino acid residues that are important in hENT3 transport of 3"-deoxy-nucleoside analogs may present a possible mechanism for overcoming the adverse toxicities associated with 3"-deoxy-nucleoside analog treatment and may guide rational development of novel nucleoside analogs.	Nucleosides	120-130	solute carrier family 29 member 3	Homo sapiens	92-97
29715301-2	2018	dCK is responsible for phosphorylation of deoxycytidine (dC, 2) and other nucleoside analogs, plays a key role in immune activation and has demonstrated to be one of the key enzymes in activating nucleoside based drugs including gemcitabine.	Nucleosides	74-84	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	0-3
29715301-2	2018	dCK is responsible for phosphorylation of deoxycytidine (dC, 2) and other nucleoside analogs, plays a key role in immune activation and has demonstrated to be one of the key enzymes in activating nucleoside based drugs including gemcitabine.	Nucleosides	196-206	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	0-3
29525433-0	2018	The aminopyridine-3,5-dicarbonitrile core for the design of new non-nucleoside-like agonists of the human adenosine A2B receptor.	Nucleosides	68-78	adenosine A2b receptor	Homo sapiens	106-128
29695239-5	2018	Resistance was shown to be mediated by down-regulation of the deoxycytidine kinase (dCK) protein, responsible for activation of nucleoside analogue prodrugs.	Nucleosides	128-138	deoxycytidine kinase	Homo sapiens	62-82
29695239-5	2018	Resistance was shown to be mediated by down-regulation of the deoxycytidine kinase (dCK) protein, responsible for activation of nucleoside analogue prodrugs.	Nucleosides	128-138	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	84-87
29695239-6	2018	This key event, emphasized by cross-resistance to other nucleoside analogues, did not only effect resistance but also levels of SPIB and NF-kappaB, as assessed through forced overexpression in resistant cells.	Nucleosides	56-66	Spi-B transcription factor	Homo sapiens	128-132
29695239-6	2018	This key event, emphasized by cross-resistance to other nucleoside analogues, did not only effect resistance but also levels of SPIB and NF-kappaB, as assessed through forced overexpression in resistant cells.	Nucleosides	56-66	nuclear factor kappa B subunit 1	Homo sapiens	137-146
28861857-1	2018	Human guanylate kinase (hGMPK) is a critical enzyme that, in addition to phosphorylating its physiological substrate (d)GMP, catalyzes the second phosphorylation step in the conversion of anti-viral and anti-cancer nucleoside analogs to their corresponding active nucleoside analog triphosphates.	Nucleosides	215-225	guanylate kinase 1	Homo sapiens	6-22
29625894-5	2018	The 5"-xCx DNA bound the site corresponding to the nucleoside binding site in TLR7 and TLR8 as revealed by the structural analysis.	Nucleosides	51-61	toll like receptor 7	Homo sapiens	78-82
29625894-5	2018	The 5"-xCx DNA bound the site corresponding to the nucleoside binding site in TLR7 and TLR8 as revealed by the structural analysis.	Nucleosides	51-61	toll like receptor 8	Homo sapiens	87-91
29524424-6	2018	Further studies with GTP, ITP, guanosine and inosine showed that pretreatment with these nucleotides/nucleosides also suppressed release of IL-6.	Nucleosides	101-112	interleukin 6	Mus musculus	140-144
28861857-1	2018	Human guanylate kinase (hGMPK) is a critical enzyme that, in addition to phosphorylating its physiological substrate (d)GMP, catalyzes the second phosphorylation step in the conversion of anti-viral and anti-cancer nucleoside analogs to their corresponding active nucleoside analog triphosphates.	Nucleosides	264-274	guanylate kinase 1	Homo sapiens	6-22
29246928-4	2018	Here, we describe a novel method to identify microRNA targets using miR-29b mimics containing 3-cyanovinylcarbazole (CNVK), a photolabile nucleoside analog.	Nucleosides	138-148	microRNA 29b-1	Homo sapiens	68-75
29555969-5	2018	Additionally, nucleosides improved intestinal barrier function through induction of TFF3-mediated phosphatidylinositol 3-kinase/Akt, extracellular signal-regulated kinase 1/2, p38, and Janus kinase/signal transducer and activator of transcription signaling pathways.	Nucleosides	14-25	trefoil factor 3	Sus scrofa	84-88
29467189-1	2018	SUPPRESSOR OF PHYB-4#5DOMINANT (sob5-D) was previously identified as a suppressor of the phyB-4 long-hypocotyl phenotype in Arabidopsis thaliana Overexpression of SOB5 conferred dwarf phenotypes similar to those observed in plants containing elevated levels of cytokinin (CK) nucleotides and nucleosides.	Nucleosides	292-303	suppressor of phytochrome b 5	Arabidopsis thaliana	32-36
29467189-1	2018	SUPPRESSOR OF PHYB-4#5DOMINANT (sob5-D) was previously identified as a suppressor of the phyB-4 long-hypocotyl phenotype in Arabidopsis thaliana Overexpression of SOB5 conferred dwarf phenotypes similar to those observed in plants containing elevated levels of cytokinin (CK) nucleotides and nucleosides.	Nucleosides	292-303	suppressor of phytochrome b 5	Arabidopsis thaliana	163-167
29555969-5	2018	Additionally, nucleosides improved intestinal barrier function through induction of TFF3-mediated phosphatidylinositol 3-kinase/Akt, extracellular signal-regulated kinase 1/2, p38, and Janus kinase/signal transducer and activator of transcription signaling pathways.	Nucleosides	14-25	AKT serine/threonine kinase 1	Sus scrofa	128-131
29555969-5	2018	Additionally, nucleosides improved intestinal barrier function through induction of TFF3-mediated phosphatidylinositol 3-kinase/Akt, extracellular signal-regulated kinase 1/2, p38, and Janus kinase/signal transducer and activator of transcription signaling pathways.	Nucleosides	14-25	mitogen-activated protein kinase 3	Sus scrofa	133-174
29955725-8	2018	Dietary nucleoside supplementation also increased plasma folate concentrations in ApcMin/+ mice, as has been observed in the Shmt1+/- mouse model.	Nucleosides	8-18	serine hydroxymethyltransferase 1 (soluble)	Mus musculus	125-130
28265856-0	2018	DRAM Is Involved in Regulating Nucleoside Analog-Induced Neuronal Autophagy in a p53-Independent Manner.	Nucleosides	31-41	DNA damage regulated autophagy modulator 1	Homo sapiens	0-4
29452403-3	2018	Double-stranded RNA and single-stranded DNA directly bind to TLR3 and TLR9, respectively, whereas TLR7 and TLR8 bind to nucleosides and oligoribonucleotides derived from RNAs.	Nucleosides	120-131	toll like receptor 7	Homo sapiens	98-102
29452403-3	2018	Double-stranded RNA and single-stranded DNA directly bind to TLR3 and TLR9, respectively, whereas TLR7 and TLR8 bind to nucleosides and oligoribonucleotides derived from RNAs.	Nucleosides	120-131	toll like receptor 8	Homo sapiens	107-111
29393406-1	2018	Deoxycytidine kinase (dCK) is a rate limiting enzyme critical for the phosphorylation of endogenous deoxynucleosides and for the anti-tumor activity of many nucleoside analogs.	Nucleosides	105-115	deoxycytidine kinase	Homo sapiens	0-20
29393406-1	2018	Deoxycytidine kinase (dCK) is a rate limiting enzyme critical for the phosphorylation of endogenous deoxynucleosides and for the anti-tumor activity of many nucleoside analogs.	Nucleosides	105-115	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
28265856-0	2018	DRAM Is Involved in Regulating Nucleoside Analog-Induced Neuronal Autophagy in a p53-Independent Manner.	Nucleosides	31-41	tumor protein p53	Homo sapiens	81-84
29416085-1	2018	Ecto-nucleotidase enzymes catalyze the hydrolysis of extracellular nucleotides to their respective nucleosides.	Nucleosides	99-110	tripartite motif containing 33	Homo sapiens	0-4
29323872-1	2018	Fludarabine, a nucleoside analogue antimetabolite, has complicated pharmacokinetics requiring facilitated transmembrane transport and intracellular conversion to triphosphate nucleotide form (Ara-FATP), causing it to be susceptible to emergence of drug resistance.	Nucleosides	15-25	solute carrier family 27 member 1	Homo sapiens	196-200
29323872-4	2018	We show that Ara-FATP has limited cytotoxic activity toward investigated cells relative to free nucleoside (Ara-FA), but complexation with the glycodendrimer (which does not otherwise influence cellular metabolism) drastically increases its toxicity.	Nucleosides	96-106	solute carrier family 27 member 1	Homo sapiens	17-21
29326016-1	2018	New nucleoside derivatives with nitrogen substitution at the C-6 position were prepared and screened initially for their in vitro anticancer bioactivity against human epithelial cancer cells (liver Huh7, colon HCT116, breast MCF7) by the NCI-sulforhodamine B assay.	Nucleosides	4-14	MIR7-3 host gene	Homo sapiens	198-202
29314771-5	2018	This is the first time that a nucleoside inhibitor is reported to completely inhibit the angiogenic activity of hAng in vivo by exerting dual inhibitory activity on hAng, blocking both the entrance of hAng into the cell and its ribonucleolytic activity.	Nucleosides	30-40	angiogenin	Homo sapiens	112-116
29314771-5	2018	This is the first time that a nucleoside inhibitor is reported to completely inhibit the angiogenic activity of hAng in vivo by exerting dual inhibitory activity on hAng, blocking both the entrance of hAng into the cell and its ribonucleolytic activity.	Nucleosides	30-40	angiogenin	Homo sapiens	165-169
29314771-5	2018	This is the first time that a nucleoside inhibitor is reported to completely inhibit the angiogenic activity of hAng in vivo by exerting dual inhibitory activity on hAng, blocking both the entrance of hAng into the cell and its ribonucleolytic activity.	Nucleosides	30-40	angiogenin	Homo sapiens	165-169
28480589-4	2018	METHODS: We have used a nucleoside analog, pyrrolo-2"-deoxycytidine, as an imaging probe for the putative reporter gene, Drosophila melanogaster 2"-deoxynucleoside kinase.	Nucleosides	24-34	deoxyribonucleoside kinase	Drosophila melanogaster	145-170
29534608-3	2018	This review summarizes available information on antiviral research of nucleoside analogs against arthropod-borne members of the genus Flavivirus within the family Flaviviridae, being primarily focused on description of nucleoside inhibitors of flaviviral RNA-dependent RNA polymerase, methyltransferase, and helicase/NTPase.	Nucleosides	70-80	helicase for meiosis 1	Homo sapiens	308-316
29216365-5	2018	TDP1 can promiscuously process several blocked 3" ends generated by DNA damaging agents and nucleoside analogs in addition to hydrolyzing 3"-phosphotyrosyl residues.	Nucleosides	92-102	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	0-4
29534608-3	2018	This review summarizes available information on antiviral research of nucleoside analogs against arthropod-borne members of the genus Flavivirus within the family Flaviviridae, being primarily focused on description of nucleoside inhibitors of flaviviral RNA-dependent RNA polymerase, methyltransferase, and helicase/NTPase.	Nucleosides	70-80	inosine triphosphatase	Homo sapiens	317-323
30465505-5	2018	Among these inhibitors, the nucleoside analogue azacytidine and its deoxy derivative decitabine are both irreversible DNMT inhibitors and approved for the treatment of myelodysplastic syndrome.	Nucleosides	28-38	DNA methyltransferase 1	Homo sapiens	118-122
29038020-0	2017	The Ca2+/CaMKK2 axis mediates the telbivudine induced upregulation of creatine kinase: Implications for mechanism of antiviral nucleoside analogs" side effect.	Nucleosides	127-137	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	9-15
29663899-5	2018	RESULTS: In 14 patients out of 15, the following mutations were observed; Nucleoside RT Inhibitor (NRTI)-Resistance Mutations with the prevalence of 11 patients having this mutation at codon 184 (73%) and Non-Nucleoside RT Inhibitor (NNRTI)-Resistance Mutations with the prevalence of 8 patients having NNRTI mutations at codon 103(53%).In 17 patients, major Protease Inhibitor (PI) Resistance Mutations were found out in 2 (12%) of them while the minor PI was found in7 (41%) patients.	Nucleosides	74-84	serpin family A member 13, pseudogene	Homo sapiens	359-377
29174536-1	2017	Decitabine (DAC), a nucleoside-related DNA methylation inhibitor, is taken up into cancer cells via equilibrative nucleoside transporter 1 (ENT1), and is then monophosphorylated by deoxycytidine kinase (dCK).	Nucleosides	20-30	arylacetamide deacetylase	Homo sapiens	12-15
29177353-2	2017	Recently, inhibition of histidine nucleotide binding protein 1 (Hint1) with a small nucleoside inhibitor has shown promise as a new therapeutic strategy for the treatment of neuropathic pain.	Nucleosides	84-94	histidine triad nucleotide binding protein 1	Homo sapiens	24-62
29177353-2	2017	Recently, inhibition of histidine nucleotide binding protein 1 (Hint1) with a small nucleoside inhibitor has shown promise as a new therapeutic strategy for the treatment of neuropathic pain.	Nucleosides	84-94	histidine triad nucleotide binding protein 1	Homo sapiens	64-69
29065681-4	2017	Direct analysis of urine, serum, and cell lysate samples by using the proposed microfluidic VAL-DESI-MS/MS method to detect chemical compounds of biomedical interest, including nucleosides, monoamines, amino acids, and peptides is demonstrated.	Nucleosides	177-188	desumoylating isopeptidase 2	Homo sapiens	96-100
28961890-13	2017	Conclusions: Lack of rRNA recycling in rns2-2 cells triggers a change in carbon flux, which is redirected through the PPP to produce ribose-5-phosphate for de novo nucleoside synthesis.	Nucleosides	164-174	ribonuclease 2	Arabidopsis thaliana	39-43
28931682-6	2017	Several nucleoside analogue RTIs (NRTIs) blocked K103 RT activity and consistently inhibited the replication of HK2 genomes.	Nucleosides	8-18	hexokinase 2	Homo sapiens	112-115
29142236-10	2017	The model should help to forecast the outcome of IFN-alpha treatment prior to therapy decision involving nucleoside analogs or IFNs.	Nucleosides	105-115	interferon alpha 1	Homo sapiens	49-58
28956767-9	2017	Taken together, our results demonstrate that the exonuclease activity of UL12 is essential for the production of infectious virus and may be considered a target for development of antiviral agents.IMPORTANCE Herpes simplex virus is a major pathogen, and although nucleoside analogs such as acyclovir are highly effective in controlling HSV-1 or -2 infections in immunocompetent individuals, their use in immunocompromised patients is complicated by the development of resistance.	Nucleosides	263-273	deoxyribonuclease	Human alphaherpesvirus 1	73-77
28802254-0	2017	TDP1 is Critical for the Repair of DNA Breaks Induced by Sapacitabine, a Nucleoside also Targeting ATM- and BRCA-Deficient Tumors.	Nucleosides	73-83	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	0-4
29137116-0	2017	Altering Residue 134 Confers an Increased Substrate Range of Alkylated Nucleosides to the E. coli OGT Protein.	Nucleosides	71-82	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	98-101
29137116-7	2017	Finally, a method to generate a covalent conjugate between hAGT and a model nucleoside using a single-stranded oligonucleotide substrate is demonstrated.	Nucleosides	76-86	angiotensinogen	Homo sapiens	59-63
29119917-3	2017	METHODS: Unlike human purine nucleoside phosphorylase (PNP), E. coli PNP accepts adenine containing nucleosides as substrates, and is therefore able to selectively activate non-toxic purine analogs in tumor tissue.	Nucleosides	100-111	purine nucleoside phosphorylase	Homo sapiens	69-72
28371417-5	2017	Molecular docking of synthesized compounds confirmed high affinity of these compounds to two different receptors for anticancer nucleosides on dCK, namely the 1P5Z and 2ZIA, showing scores higher than the cognate ligand for all tested compounds.	Nucleosides	128-139	dreadlocks	Drosophila melanogaster	143-146
28968467-6	2017	Moreover, we discovered that nucleoside supplementation will override the loss of cell viability in response to p21CIP1 depletion, suggesting that p21CIP1 depletion causes lethal replication stress.	Nucleosides	29-39	cyclin dependent kinase inhibitor 1A	Homo sapiens	112-119
28968467-6	2017	Moreover, we discovered that nucleoside supplementation will override the loss of cell viability in response to p21CIP1 depletion, suggesting that p21CIP1 depletion causes lethal replication stress.	Nucleosides	29-39	cyclin dependent kinase inhibitor 1A	Homo sapiens	147-154
29119052-1	2017	Trifluridine/tipiracil (FTD/TPI) is a combination of FTD, an antineoplastic thymidine-based nucleoside analog, and TPI, which acts to enhance the bioavailability of FTD in vivo.	Nucleosides	92-102	triosephosphate isomerase 1	Mus musculus	28-31
28720669-6	2017	Pretreatment with the glycolysis inhibitor 3-bromopyruvate abrogated MUC1-mediated radiation resistance both in vitro and in vivo, by reducing glucose flux into nucleotide biosynthetic pathways and enhancing DNA damage, which could again be reversed by pretreatment with nucleoside pools.Conclusions: MUC1-mediated nucleotide metabolism plays a key role in facilitating radiation resistance in pancreatic cancer and targeted effectively through glycolytic inhibition.	Nucleosides	271-281	mucin 1, cell surface associated	Homo sapiens	69-73
27641077-8	2017	In contrast, two nucleosides, uridine and adenosine, minimally interacted with PMAT/Pmat in all species.	Nucleosides	17-28	solute carrier family 29 member 4	Homo sapiens	79-83
27641077-8	2017	In contrast, two nucleosides, uridine and adenosine, minimally interacted with PMAT/Pmat in all species.	Nucleosides	17-28	solute carrier family 29 member 4	Homo sapiens	84-88
28153452-4	2017	This nucleoside can also participate in the early development of atherosclerosis by inhibiting the formation of foam cells via stimulation of cholesterol efflux through A2AR expressed on macrophages and reduction of the inflammatory process by activating A2AR and A2BR.	Nucleosides	5-15	adenosine A2a receptor	Homo sapiens	169-173
29423136-4	2017	(S)-Methanocarba dinucleotide potency was compatible with a N4-methoxy modification on the proximal nucleoside that is assumed to bind at the P2Y6R similarly to UDP; (N)-methanocarba was preferred on the distal nucleoside moiety.	Nucleosides	100-110	pyrimidinergic receptor P2Y6	Homo sapiens	142-147
28829913-2	2017	Acyclic nucleoside analogues used in this study were identified through a virtual screening using HIV-reverse transcriptase (RT), adenylate/guanylate kinase, and human DNA polymerase gamma.	Nucleosides	8-18	guanylate kinase 1	Homo sapiens	140-156
28729424-2	2017	Unlike the prototypic human ENT members hENT1 and hENT2, which mediate plasma membrane nucleoside transport at pH 7.4, hENT3 is an acidic pH-activated lysosomal transporter partially localized to mitochondria.	Nucleosides	87-97	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	40-45
28729424-2	2017	Unlike the prototypic human ENT members hENT1 and hENT2, which mediate plasma membrane nucleoside transport at pH 7.4, hENT3 is an acidic pH-activated lysosomal transporter partially localized to mitochondria.	Nucleosides	87-97	solute carrier family 29 member 2	Homo sapiens	50-55
28729424-2	2017	Unlike the prototypic human ENT members hENT1 and hENT2, which mediate plasma membrane nucleoside transport at pH 7.4, hENT3 is an acidic pH-activated lysosomal transporter partially localized to mitochondria.	Nucleosides	87-97	solute carrier family 29 member 3	Homo sapiens	119-124
28729424-5	2017	Therefore, we sought to examine the mechanistic basis of acidic pH-driven hENT3 nucleoside transport with site-directed mutagenesis, homology modeling, and [3H]adenosine flux measurements in mutant RNA-injected Xenopus oocytes.	Nucleosides	80-90	solute carrier family 29 member 3	Homo sapiens	74-79
28795598-2	2017	Nowadays, non-nucleoside DNMT inhibitors are in development to address high toxicity of nucleoside analogs.	Nucleosides	14-24	DNA methyltransferase 1	Homo sapiens	25-29
28854883-0	2017	Addition of nucleoside analogues to peg-IFNalpha-2a enhances virological response in chronic hepatitis B patients without early response to peg-IFNalpha-2a: a randomized controlled trial.	Nucleosides	12-22	interferon alpha 1	Homo sapiens	40-48
28842605-4	2017	In ex vivo glomeruli, high D-glucose decreased nucleoside uptake mediated by ENT1 and ENT2 transporters, resulting in augmented extracellular levels of adenosine.	Nucleosides	47-57	solute carrier family 29 member 1	Rattus norvegicus	77-81
28815216-7	2017	A second drug-selected mutation, PA T97I, interacts epistatically with PB1 T123A to mediate high-level mutagen resistance, predominantly by limiting the inhibitory effect of nucleosides on polymerase activity.	Nucleosides	174-185	polybromo 1	Homo sapiens	71-74
28414100-1	2017	Cytidine monophosphate kinase (CMPK), a member of the nucleoside monophosphate kinase family, plays an important role in the biosynthesis of nucleoside metabolism, DNA repair and tumour development.	Nucleosides	54-64	cytidine/uridine monophosphate kinase 1	Homo sapiens	0-29
28414100-1	2017	Cytidine monophosphate kinase (CMPK), a member of the nucleoside monophosphate kinase family, plays an important role in the biosynthesis of nucleoside metabolism, DNA repair and tumour development.	Nucleosides	54-64	cytidine/uridine monophosphate kinase 1	Homo sapiens	31-35
27189619-3	2017	ATP hydrolysis by ectonucleotidases is an important source of adenosine, and adenosine deaminase (ADA) contributes to the control of the nucleoside concentrations.	Nucleosides	137-147	adenosine deaminase	Danio rerio	77-96
28470260-0	2017	Effect of nucleoside analogue antimetabolites on the structure of PEO-PPO-PEO micelles investigated by SANS.	Nucleosides	10-20	USH1 protein network component sans	Homo sapiens	103-107
28513173-1	2017	The study concerns the relaxation of electronic excited states of the DNA nucleoside deoxycytidine (dCyd) and its methylated analogue 5-methyldeoxycytidine (5mdCyd), known to be involved in the formation of UV-induced lesions of the genetic code.	Nucleosides	74-84	Cyd	Drosophila melanogaster	100-104
28436707-5	2017	Within this Extra View, we discuss and build upon both these and our previously reported findings, and propose SAMHD1 is likely active against a variety of nucleoside analog antimetabolites present in anti-cancer chemotherapies.	Nucleosides	156-166	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	111-117
28766335-5	2017	Additionally, NFS1 is also located in smaller amounts in the cytosol with a role in Moco biosynthesis and mcm5s2U34 thio modifications of nucleosides in tRNA.	Nucleosides	138-149	NFS1 cysteine desulfurase	Homo sapiens	14-18
28502830-5	2017	However, SAMHD1 also can act as a resistance factor to nucleoside-based chemotherapies by hydrolyzing their active triphosphate metabolites, thereby reducing response of various malignancies to these anticancer drugs.	Nucleosides	55-65	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	9-15
28716944-2	2017	Nucleoside analogs such as gemcitabine diphosphate and clofarabine nucleotides target the large subunit (hRRM1) of hRR.	Nucleosides	0-10	ribonucleotide reductase catalytic subunit M1	Homo sapiens	105-110
28487312-1	2017	Cd39 scavenges extracellular ATP and ADP, ultimately generating adenosine, a nucleoside, which has anti-inflammatory effects in the vasculature.	Nucleosides	77-87	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	0-4
28359840-5	2017	Similarly, in SAMHD1 knockout cells, HIV-1 showed increased replicative capacity in the presence of nucleoside inhibitors, especially AZT, that was reverted by re-expression of wild type SAMHD1.	Nucleosides	100-110	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	14-20
28359840-5	2017	Similarly, in SAMHD1 knockout cells, HIV-1 showed increased replicative capacity in the presence of nucleoside inhibitors, especially AZT, that was reverted by re-expression of wild type SAMHD1.	Nucleosides	100-110	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	187-193
28359840-8	2017	Our results demonstrate that SAMHD1 is active in HIV-1 permissive cells, does not modify susceptibility to HIV-1 infection but strongly affects sensitivity to nucleoside inhibitors.	Nucleosides	159-169	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	29-35
28504647-0	2017	Identification of a nucleoside analog active against adenosine kinase-expressing plasma cell malignancies.	Nucleosides	20-30	adenosine kinase	Mus musculus	53-69
28504647-9	2017	Several nucleoside analogs are effective in treating leukemias and T cell lymphomas, and 6-ETI may fill this niche for the treatment of PEL, plasmablastic lymphoma, MM, and other ADK-expressing cancers.	Nucleosides	8-18	adenosine kinase	Mus musculus	179-182
28153452-4	2017	This nucleoside can also participate in the early development of atherosclerosis by inhibiting the formation of foam cells via stimulation of cholesterol efflux through A2AR expressed on macrophages and reduction of the inflammatory process by activating A2AR and A2BR.	Nucleosides	5-15	adenosine A2a receptor	Homo sapiens	255-259
28254415-1	2017	The human equilibrative nucleoside transporter-1 (hENT1) is important for the entry of anti-cancer and anti-viral nucleoside analog therapeutics into the cell, and thus for their efficacy.	Nucleosides	24-34	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	50-55
28620298-4	2017	TLR7 can be triggered not only by ssRNA during viral infections, but also by immune modifiers that share a similar structure to nucleosides.	Nucleosides	128-139	toll like receptor 7	Homo sapiens	0-4
28529533-3	2017	Furthermore, cellular response to this nucleoside is highly dependent on its extracellular concentration that is regulated by ecto-enzymes such as CD39 and CD73.	Nucleosides	39-49	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	147-151
28529533-3	2017	Furthermore, cellular response to this nucleoside is highly dependent on its extracellular concentration that is regulated by ecto-enzymes such as CD39 and CD73.	Nucleosides	39-49	5'-nucleotidase ecto	Homo sapiens	156-160
28254415-2	2017	Understanding of hENT1 structure-function relationship could assist with development of nucleoside analogs with better cellular uptake properties.	Nucleosides	88-98	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	17-22
28340480-8	2017	Thirdly, the preliminary identified nucleoside structures lacking of characteristic fragment ions were verified by UHPLC Q-Trap/MS in multiple reaction monitoring trigger enhanced product ion scan (MRM-EPI) and neutral loss scan (NL).	Nucleosides	36-46	TRAP	Homo sapiens	123-127
28346230-6	2017	GLS1 inhibitor-induced nucleoside depletion and ROS enhancement led to DNA replication stress and activation of an intra-S phase checkpoint, and suppressed the growth of VHL-/- RCC cells.	Nucleosides	23-33	glutaminase	Homo sapiens	0-4
28209616-0	2017	OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues.	Nucleosides	36-46	solute carrier family 22 member 4	Homo sapiens	0-5
28340480-10	2017	Fifty-five nucleosides were primarily identified by UPLC Q-TOF/MS, among which 50 nucleosides were confirmed by UHPLC Q-Trap/MS.	Nucleosides	82-93	TRAP	Homo sapiens	120-124
28417642-3	2017	In vitro expression levels of equilibrative nucleoside transporter 1 (ENT1) has been shown to be a predictor of treatment response in patients receiving nucleoside-based chemotherapeutic agents.	Nucleosides	44-54	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	70-74
28338689-6	2017	In addition to the canonical nucleosides, our synthesis accesses beta-2-thioribouridine, a modified nucleoside found in transfer RNA that enables both faster and more-accurate nucleic acid template-copying chemistry.	Nucleosides	29-40	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	65-71
27995448-6	2017	Adenosine uptake by hENT1 is competitively inhibited by nitrobenzylmercaptopurine ribonucleoside (NBMPR), nucleosides, deoxynucleosides, and nucleoside-derived anti-cancer and anti-viral drugs.	Nucleosides	106-117	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	20-25
27995448-6	2017	Adenosine uptake by hENT1 is competitively inhibited by nitrobenzylmercaptopurine ribonucleoside (NBMPR), nucleosides, deoxynucleosides, and nucleoside-derived anti-cancer and anti-viral drugs.	Nucleosides	86-96	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	20-25
27935283-0	2017	A Single Deoxynucleoside Kinase Variant from Drosophila melanogaster Synthesizes Monophosphates of Nucleosides That Are Components of an Expanded Genetic System.	Nucleosides	99-110	deoxyribonucleoside kinase	Drosophila melanogaster	9-31
27935283-2	2017	Here, we show that replacing a single amino acid (glutamine 81 by glutamate) in DmdNK creates a variant that also catalyzes the phosphorylation of nucleosides that form part of an artificially expanded genetic information system (AEGIS).	Nucleosides	147-158	deoxyribonucleoside kinase	Drosophila melanogaster	80-85
28249574-14	2017	CONCLUSIONS: This case-report highlights the risk of HBV reactivation with interferon-free DAA treatment in HIV/HCV co-infected patients previously exposed to HBV and who have contraindications for treatment with nucleoside/nucleotide reverse transcriptase Inhibitors because of comorbid conditions.	Nucleosides	213-223	interferon alpha 1	Homo sapiens	75-85
29167753-6	2017	External validation of the homology models was carried out by docking a set of recently reported known hCNT1 nucleoside class inhibitors at the putative binding site using induced fit docking (IDF) methodology with the Glide docking program.	Nucleosides	109-119	solute carrier family 28 member 1	Homo sapiens	103-108
28220857-0	2017	SAMHD1 enhances nucleoside-analogue efficacy against HIV-1 in myeloid cells.	Nucleosides	16-26	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	0-6
28251649-6	2017	The reduction to 1% in oxygen supply (2 h) to cells decreased the levels of released PNP, leading to an increased presence of extracellular nucleosides and to a reduced formation of xanthine and uric acid.	Nucleosides	140-151	purine nucleoside phosphorylase	Rattus norvegicus	85-88
28218790-1	2017	Human equilibrative nucleoside transporters (hENT) 1 and 2, encoded by SLC29A1 and SLC29A2, permit the bidirectional passage of nucleoside analogues into cells and may correlate with clinical responses to chemotherapy in patients with colorectal cancer (CRC).	Nucleosides	20-30	solute carrier family 29 member 2	Homo sapiens	83-90
28089947-10	2017	The (PhSe)2 treatment of healthy animals altered the levels of nucleosides, possibly due to low XO activity that decreased nucleoside degradation.	Nucleosides	63-74	xanthine dehydrogenase	Mus musculus	96-98
28112929-9	2017	The fluorescence-based approach using these two different fluorescent nucleoside surrogates advances the mechanistic understanding of the UHRF1/DNMT1 tandem and the development of assays for the identification of base flipping inhibitors.	Nucleosides	70-80	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	138-143
28052021-1	2017	BACKGROUND: Previous studies have revealed that hepatitis B core antibody (anti-HBc) levels vary throughout the different phases of treatment-naive chronic hepatitis B (CHB) patients and can be used as a predictor of treatment response in both interferon-alpha and nucleoside analogue therapies.	Nucleosides	265-275	keratin 88, pseudogene	Homo sapiens	80-83
28112929-9	2017	The fluorescence-based approach using these two different fluorescent nucleoside surrogates advances the mechanistic understanding of the UHRF1/DNMT1 tandem and the development of assays for the identification of base flipping inhibitors.	Nucleosides	70-80	DNA methyltransferase 1	Homo sapiens	144-149
28403982-8	2017	According to specific guidelines, nucleoside analogue prophylaxis is recommended in anti-HBc-positive liver allograft recipients and anti-HBc alone individuals who receive chemotherapy or biological therapy and should be continued for 6-12 months after discontinuation of such immunosuppressive therapies to protect against HBV reactivation.	Nucleosides	34-44	keratin 88, pseudogene	Homo sapiens	89-92
28218790-1	2017	Human equilibrative nucleoside transporters (hENT) 1 and 2, encoded by SLC29A1 and SLC29A2, permit the bidirectional passage of nucleoside analogues into cells and may correlate with clinical responses to chemotherapy in patients with colorectal cancer (CRC).	Nucleosides	20-30	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	71-78
28046007-9	2017	Importantly, our data is beneficial for understanding if FDA-approved antiviral and anticancer nucleosides are hydrolyzed by SAMHD1 in vivo.	Nucleosides	95-106	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	125-131
27991919-5	2017	Although it has been postulated that SAMHD1 sensitizes cancer cells to nucleoside-analog derivatives through the depletion of competing dNTPs, we show here that SAMHD1 reduces Ara-C cytotoxicity in AML cells.	Nucleosides	71-81	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	37-43
27991919-5	2017	Although it has been postulated that SAMHD1 sensitizes cancer cells to nucleoside-analog derivatives through the depletion of competing dNTPs, we show here that SAMHD1 reduces Ara-C cytotoxicity in AML cells.	Nucleosides	71-81	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	161-167
27815125-3	2017	Doug Richman (Elion Award) investigated HIV resistance, Bob Vince (Holy Award) showed how carbocyclic nucleoside analogs led to abacavir and Jerome Deval (Prusoff Award) explained how his group chose to seek a nucleoside analog to treat RSV.	Nucleosides	102-112	G protein-coupled receptor 15	Homo sapiens	56-59
27815125-3	2017	Doug Richman (Elion Award) investigated HIV resistance, Bob Vince (Holy Award) showed how carbocyclic nucleoside analogs led to abacavir and Jerome Deval (Prusoff Award) explained how his group chose to seek a nucleoside analog to treat RSV.	Nucleosides	210-220	G protein-coupled receptor 15	Homo sapiens	56-59
28296564-6	2017	The addition of exogenous nucleosides to combination therapy significantly rescued the increased DS-DNA breaks and caspase-3 dependent apoptosis almost to the levels of 5-FU monotherapy.	Nucleosides	26-37	caspase 3	Homo sapiens	115-124
28601222-0	2017	Synthesis, Function, and Heterogeneity of snoRNA-Guided Posttranscriptional Nucleoside Modifications in Eukaryotic Ribosomal RNAs.	Nucleosides	76-86	small nucleolar RNA, C/D box 14D	Homo sapiens	42-48
27655859-3	2017	We aimed to compare the efficacy of an integrase inhibitor versus a non-nucleoside to normalize the CD4/CD8 ratio.	Nucleosides	72-82	CD4 molecule	Homo sapiens	100-103
27577111-6	2017	Along pregnancy, apoptotic caspase-3 activation increased 63.64 +- 45.45% in controls (P < 0.001) and 100.00 +- 47.37% in HIV-pregnancies (P < 0.001), in correlation with longer exposure to nucleoside analogues.	Nucleosides	196-206	caspase 3	Homo sapiens	27-36
27655859-3	2017	We aimed to compare the efficacy of an integrase inhibitor versus a non-nucleoside to normalize the CD4/CD8 ratio.	Nucleosides	72-82	CD8a molecule	Homo sapiens	104-107
27918552-9	2016	NEIL1 DNA glycosylase, involved in repair of oxidized nucleosides, was found to be significantly downregulated as a cellular response to MTH1-MYH co-suppression.	Nucleosides	54-65	nei like DNA glycosylase 1	Homo sapiens	0-5
27866910-5	2016	Subsequent functional validation suggested that inhibition of DCK by niraparib could have detrimental effects when combined with nucleoside analog pro-drugs.	Nucleosides	129-139	deoxycytidine kinase	Homo sapiens	62-65
27918552-9	2016	NEIL1 DNA glycosylase, involved in repair of oxidized nucleosides, was found to be significantly downregulated as a cellular response to MTH1-MYH co-suppression.	Nucleosides	54-65	nudix hydrolase 1	Homo sapiens	137-141
27918552-9	2016	NEIL1 DNA glycosylase, involved in repair of oxidized nucleosides, was found to be significantly downregulated as a cellular response to MTH1-MYH co-suppression.	Nucleosides	54-65	mutY DNA glycosylase	Homo sapiens	142-145
27906612-1	2016	The 5"-nucleotidase cN-II has been shown to be associated with the sensitivity to nucleoside analogues, the survival of cytarabine treated leukemia patients and to cell proliferation.	Nucleosides	82-92	5'-nucleotidase ecto	Homo sapiens	4-19
27644733-11	2016	CONCLUSIONS: Serum HBcrAg positivity is a significant risk factor of HBV reactivation in HBsAg-negative, anti-HBc-positive patients undergoing high-risk immunosuppressive therapy and can potentially have a role in identifying patients who will best benefit from prophylactic nucleoside analogue treatment.	Nucleosides	275-285	keratin 88, pseudogene	Homo sapiens	19-22
27271752-0	2016	Novel nuclear hENT2 isoforms regulate cell cycle progression via controlling nucleoside transport and nuclear reservoir.	Nucleosides	77-87	solute carrier family 29 member 2	Homo sapiens	14-19
27271752-4	2016	Under proliferative conditions, these splice variants are up-regulated and recruit wild-type ENT2 to the nuclear envelope to translocate nucleosides into the nucleus for incorporation into DNA during replication.	Nucleosides	137-148	solute carrier family 29 member 2	Homo sapiens	93-97
27271752-6	2016	Our findings support a novel model of nucleoside compartmentalisation at the nuclear envelope and translocation into the nucleus through hENT2 and its variants, which are essential for effective DNA synthesis and cell proliferation.	Nucleosides	38-48	solute carrier family 29 member 2	Homo sapiens	137-142
27903293-1	2016	ABAT deficiency (OMIM 613163) is a rare inborn error of metabolism caused by recessive variants in the gene 4-aminobutyric acid transaminase (ABAT), which is responsible for both the catalysis of GABA and maintenance of nucleoside pools in the mitochondria.	Nucleosides	220-230	4-aminobutyrate aminotransferase	Homo sapiens	108-140
27906612-1	2016	The 5"-nucleotidase cN-II has been shown to be associated with the sensitivity to nucleoside analogues, the survival of cytarabine treated leukemia patients and to cell proliferation.	Nucleosides	82-92	5'-nucleotidase, cytosolic II	Homo sapiens	20-25
27906616-1	2016	Tomato thymidine kinase 1 (ToTK1) is a deoxyribonucleoside kinase (dNK) that has been subject to study because of its potential to phosphorylate the nucleoside analogue 3-azido-2,3-dideoxythymidine (azidothymidine, AZT) equally well as its natural substrate thymidine (dThd).	Nucleosides	48-58	deoxyribonucleoside kinase	Drosophila melanogaster	67-70
27879648-1	2016	Deoxycytidine kinase (dCK) is a key enzyme in deoxyribonucleoside salvage and the anti-tumor activity for many nucleoside analogs.	Nucleosides	55-65	deoxycytidine kinase	Homo sapiens	0-20
27879648-1	2016	Deoxycytidine kinase (dCK) is a key enzyme in deoxyribonucleoside salvage and the anti-tumor activity for many nucleoside analogs.	Nucleosides	55-65	sticky	Drosophila melanogaster	22-25
27601466-10	2016	Ribose accumulation in plants lacking AtRBSK was reduced in plants also deficient in the nucleoside ribohydrolase NSH1, linking AtRBSK activity to nucleoside metabolism.	Nucleosides	89-99	uridine-ribohydrolase 1	Arabidopsis thaliana	114-118
27906634-1	2016	Human equilibrative nucleoside transporter 1 (hENT1) is a major route of entry of nucleosides and nucleoside analog drugs.	Nucleosides	82-93	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	6-44
27906634-1	2016	Human equilibrative nucleoside transporter 1 (hENT1) is a major route of entry of nucleosides and nucleoside analog drugs.	Nucleosides	82-93	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
27906634-1	2016	Human equilibrative nucleoside transporter 1 (hENT1) is a major route of entry of nucleosides and nucleoside analog drugs.	Nucleosides	20-30	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
27233214-7	2016	In contrast to RPMI1640, X-Vivo15 resulted in a significant down-regulation of the cell-surface-located ectonucleotidases CD39 (Ecto-Apyrase) and CD73 (Ecto-5"-Nucleotidase), critical for the extracellular nucleotides-hydrolysis to nucleosides, explaining the loss of inhibition mediated by dGTP and GTP, but not Guanosine.	Nucleosides	232-243	5'-nucleotidase ecto	Homo sapiens	152-172
27282729-0	2016	4-amino-6-alkyloxy-2-alkylthiopyrimidine derivatives as novel non-nucleoside agonists for the adenosine A1 receptor.	Nucleosides	66-76	adenosine A1 receptor	Homo sapiens	94-115
27374989-8	2016	We suggest that Dm eIF4E-3 and Dm eIF4E-5 bind the second nucleoside of the cap in an unusual manner via stacking interactions with a histidine or a phenylalanine residue, respectively.	Nucleosides	58-68	eukaryotic translation initiation factor 4E3	Drosophila melanogaster	19-26
28246464-2	2016	Some of the ring expanded nucleoside compounds such as REN: NZ51, fused di imidazodiazepine ring (RK33), (Z)-3-(5- (3-bromo benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-N-(2- hydroxy phenyl) propanamide compound (FE15) have been documented to inhibit DDX3 helicase activity.	Nucleosides	26-36	renin	Homo sapiens	55-58
28246464-2	2016	Some of the ring expanded nucleoside compounds such as REN: NZ51, fused di imidazodiazepine ring (RK33), (Z)-3-(5- (3-bromo benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-N-(2- hydroxy phenyl) propanamide compound (FE15) have been documented to inhibit DDX3 helicase activity.	Nucleosides	26-36	DEAD-box helicase 3 X-linked	Homo sapiens	251-255
27589566-5	2016	Validation of methylation inhibition on MIEN1 was performed using nucleoside analogs and non-nucleoside inhibitors and resulted in an increase in both MIEN1 RNA and protein in normal cells.	Nucleosides	66-76	migration and invasion enhancer 1	Homo sapiens	40-45
27589566-5	2016	Validation of methylation inhibition on MIEN1 was performed using nucleoside analogs and non-nucleoside inhibitors and resulted in an increase in both MIEN1 RNA and protein in normal cells.	Nucleosides	66-76	migration and invasion enhancer 1	Homo sapiens	151-156
27589566-5	2016	Validation of methylation inhibition on MIEN1 was performed using nucleoside analogs and non-nucleoside inhibitors and resulted in an increase in both MIEN1 RNA and protein in normal cells.	Nucleosides	93-103	migration and invasion enhancer 1	Homo sapiens	40-45
27589566-5	2016	Validation of methylation inhibition on MIEN1 was performed using nucleoside analogs and non-nucleoside inhibitors and resulted in an increase in both MIEN1 RNA and protein in normal cells.	Nucleosides	93-103	migration and invasion enhancer 1	Homo sapiens	151-156
27374989-8	2016	We suggest that Dm eIF4E-3 and Dm eIF4E-5 bind the second nucleoside of the cap in an unusual manner via stacking interactions with a histidine or a phenylalanine residue, respectively.	Nucleosides	58-68	eukaryotic translation initiation factor 4E5	Drosophila melanogaster	34-41
27556692-0	2016	Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells.	Nucleosides	54-64	checkpoint kinase 1	Mus musculus	0-4
27556692-0	2016	Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells.	Nucleosides	54-64	transformation related protein 53	Mus musculus	76-80
27325794-3	2016	In the present study, we show that exposure of HeLa cells to decitabine up-regulates the expression of several pyrimidine metabolic enzymes including DCTPP1, dUTPase, dCMP deaminase and thymidylate synthase, thus suggesting their contribution to the cellular response to this anti-cancer nucleoside.	Nucleosides	288-298	dCTP pyrophosphatase 1	Homo sapiens	150-156
27634334-7	2016	APOBEC3B activation can be attenuated through repression of oncogenic signalling, small molecule inhibition of receptor tyrosine kinase signalling and alleviation of replication stress through nucleoside supplementation.	Nucleosides	193-203	apolipoprotein B mRNA editing enzyme catalytic subunit 3B	Homo sapiens	0-8
27422302-1	2016	PURPOSE: The solute carrier family 29 (equilibrative nucleoside transporter), member 1 (SLC29A1) is known to be involved in the transportation and resistance of the nucleoside analog cytosine arabinoside (AraC), one of the most effective drugs in the treatment of acute myeloid leukemia (AML).	Nucleosides	53-63	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	88-95
27376954-2	2016	It is caused by mutations in the ABAT gene, which encodes 4-aminobutyrate transaminase, an enzyme of GABA catabolism and mitochondrial nucleoside salvage.	Nucleosides	135-145	4-aminobutyrate aminotransferase	Homo sapiens	33-37
27376954-2	2016	It is caused by mutations in the ABAT gene, which encodes 4-aminobutyrate transaminase, an enzyme of GABA catabolism and mitochondrial nucleoside salvage.	Nucleosides	135-145	4-aminobutyrate aminotransferase	Homo sapiens	58-86
27280393-7	2016	Kmt2d depletion in KC/KPC cell lines also led to an increased response to the nucleoside analogue 5-fluorouracil, suggesting that lower levels of this methyltransferase may mediate the sensitivity of PDAC to particular treatments.	Nucleosides	78-88	lysine methyltransferase 2D	Homo sapiens	0-5
27230014-0	2016	Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides.	Nucleosides	105-116	primase and DNA directed polymerase	Homo sapiens	13-20
27230014-11	2016	PrimPol(-/-) cells also exhibited increased sensitivity to a wide variety of chain-terminating nucleoside analogs (CTNAs).	Nucleosides	95-105	primase and DNA directed polymerase	Homo sapiens	0-7
27559949-1	2016	Previous studies have shown that hepatitis B core antibody (anti-HBc) levels vary during different phases of disease in treatment-naive chronic hepatitis B (CHB) patients and can be used as a predictor of both interferon-alpha and nucleoside analogue therapy response.	Nucleosides	231-241	keratin 88, pseudogene	Homo sapiens	65-68
27480168-1	2016	Human equilibrative nucleoside transporter 1 (hENT1) transports nucleosides and nucleoside analogue drugs across cellular membranes and is necessary for the uptake of many anti-cancer, anti-parasitic and anti-viral drugs.	Nucleosides	64-75	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	6-44
27480168-1	2016	Human equilibrative nucleoside transporter 1 (hENT1) transports nucleosides and nucleoside analogue drugs across cellular membranes and is necessary for the uptake of many anti-cancer, anti-parasitic and anti-viral drugs.	Nucleosides	64-75	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
27480168-1	2016	Human equilibrative nucleoside transporter 1 (hENT1) transports nucleosides and nucleoside analogue drugs across cellular membranes and is necessary for the uptake of many anti-cancer, anti-parasitic and anti-viral drugs.	Nucleosides	20-30	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
27387794-2	2016	(2016) determined crystal structures of APH(2"")-Ia in complex with various combinations of aminoglycosides and nucleosides, which compellingly revealed that the catalytic activity of this resistance enzyme is regulated by a conformational change of the triphosphate of GTP, a mechanism previously unknown for antibiotic kinases.	Nucleosides	112-123	acylaminoacyl-peptide hydrolase	Homo sapiens	40-43
27410258-2	2016	On the basis of the South (S) ribose conformation and molecular dynamics (MD) analysis of nucleoside inhibitors bound in AdK X-ray crystallographic structures, (S)- and North (N)-methanocarba (bicyclo[3.1.0]hexane) derivatives of known inhibitors were prepared and compared as human (h) AdK inhibitors.	Nucleosides	90-100	adenosine kinase	Homo sapiens	121-124
27402769-0	2016	Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion.	Nucleosides	63-73	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	0-25
27426251-1	2016	Here, we describe a novel reliable method to assess the significance of individual mutations within the thymidine kinase (TK) gene of herpes simplex virus type 1 (HSV-1) to nucleoside analogue resistance.	Nucleosides	173-183	involved in nucleotide metabolism	Human alphaherpesvirus 1	104-120
27426251-1	2016	Here, we describe a novel reliable method to assess the significance of individual mutations within the thymidine kinase (TK) gene of herpes simplex virus type 1 (HSV-1) to nucleoside analogue resistance.	Nucleosides	173-183	involved in nucleotide metabolism	Human alphaherpesvirus 1	122-124
26858310-1	2016	PURPOSE: The double-strand breaks elicited by sapacitabine, a clinically active nucleoside analogue prodrug, are repaired by RAD51 and the homologous recombination repair (HR) pathway, which could potentially limit its toxicity.	Nucleosides	80-90	RAD51 recombinase	Homo sapiens	125-130
26977746-0	2016	Nucleoside-Sparing Regimens With Raltegravir and a Boosted Protease Inhibitor: An Unsettled Issue.	Nucleosides	0-10	serpin family A member 13, pseudogene	Homo sapiens	59-77
27062582-2	2016	A typical hydrophilic interaction LC retention mechanism was observed for low-molecular weight polar compounds including amides, nucleotides, and nucleosides in the separation mode of hydrophilic interaction CEC, when high content of ACN (>60%) was used as the mobile phase.	Nucleosides	146-157	apoptotic chromatin condensation inducer 1	Homo sapiens	234-237
27154681-3	2016	This study aimed to develop and validate a method to analyze oxidized and MPO-specific chlorinated nucleosides in biological matrixes (cells, tissues and plasma).	Nucleosides	99-110	myeloperoxidase	Homo sapiens	74-77
27294910-0	2016	Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3"-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease.	Nucleosides	44-54	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	116-121
27294910-0	2016	Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3"-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease.	Nucleosides	44-54	ERCC excision repair 4, endonuclease catalytic subunit	Homo sapiens	122-125
27374090-4	2016	Indeed, co-treatment with the pan-Pim kinase inhibitor AZD1208 or expression of a kinase-dead Pim-1 mutant sensitized FLT3-ITD cell lines to apoptosis triggered by chemotherapy drugs including the topoisomerase 2 inhibitors daunorubicin, etoposide and mitoxantrone, but not the nucleoside analog cytarabine.	Nucleosides	278-288	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-37
27374090-4	2016	Indeed, co-treatment with the pan-Pim kinase inhibitor AZD1208 or expression of a kinase-dead Pim-1 mutant sensitized FLT3-ITD cell lines to apoptosis triggered by chemotherapy drugs including the topoisomerase 2 inhibitors daunorubicin, etoposide and mitoxantrone, but not the nucleoside analog cytarabine.	Nucleosides	278-288	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	94-99
27374090-4	2016	Indeed, co-treatment with the pan-Pim kinase inhibitor AZD1208 or expression of a kinase-dead Pim-1 mutant sensitized FLT3-ITD cell lines to apoptosis triggered by chemotherapy drugs including the topoisomerase 2 inhibitors daunorubicin, etoposide and mitoxantrone, but not the nucleoside analog cytarabine.	Nucleosides	278-288	fms related receptor tyrosine kinase 3	Homo sapiens	118-122
27126991-2	2016	TFT was originally synthesized in the 1960s and is a nucleoside analogue that impedes DNA synthesis by inhibition of thymidylate synthase.	Nucleosides	53-63	thymidylate synthetase	Homo sapiens	117-137
27017552-6	2016	Nucleoside protection assays establish compound 8 a dual inhibitor of thymidylate synthase (TS) and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFTase) targeting both de novo thymidylate and purine nucleotide biosynthesis, which is further verified by the molecular modeling studies.	Nucleosides	0-10	thymidylate synthetase	Homo sapiens	70-90
27280468-0	2016	Targeted Delivery of Deoxycytidine Kinase to Her2-Positive Cells Enhances the Efficacy of the Nucleoside Analog Fludarabine.	Nucleosides	94-104	deoxycytidine kinase	Homo sapiens	21-41
27280468-0	2016	Targeted Delivery of Deoxycytidine Kinase to Her2-Positive Cells Enhances the Efficacy of the Nucleoside Analog Fludarabine.	Nucleosides	94-104	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-49
27280468-4	2016	To overcome this limitation, and achieve site-targeted activation of nucleoside analogs, we fused the coding region of a prodrug-activating enzyme, deoxycytidine kinase (dCK), to affinity reagents that bind to the Her2 cell surface protein.	Nucleosides	69-79	deoxycytidine kinase	Homo sapiens	148-168
27280468-4	2016	To overcome this limitation, and achieve site-targeted activation of nucleoside analogs, we fused the coding region of a prodrug-activating enzyme, deoxycytidine kinase (dCK), to affinity reagents that bind to the Her2 cell surface protein.	Nucleosides	69-79	sticky	Drosophila melanogaster	170-173
27280468-4	2016	To overcome this limitation, and achieve site-targeted activation of nucleoside analogs, we fused the coding region of a prodrug-activating enzyme, deoxycytidine kinase (dCK), to affinity reagents that bind to the Her2 cell surface protein.	Nucleosides	69-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	214-218
27280468-9	2016	These findings demonstrate that we have succeeded in delivering active dCK into the Her2-positive cells, thereby increasing the activation of fludarabine, which ultimately reduces the dose of nucleoside analog needed for cell killing.	Nucleosides	192-202	sticky	Drosophila melanogaster	71-74
27280468-9	2016	These findings demonstrate that we have succeeded in delivering active dCK into the Her2-positive cells, thereby increasing the activation of fludarabine, which ultimately reduces the dose of nucleoside analog needed for cell killing.	Nucleosides	192-202	erb-b2 receptor tyrosine kinase 2	Homo sapiens	84-88
27016071-3	2016	We show that exposure of human fibroblasts to nucleoside analogs commonly used in antiretroviral therapies, and known to induce mitochondrial dysfunction, increases mitochondrial ROS and leads to a rise in intracellular ROS concomitant with activation of mTORC1.	Nucleosides	46-56	CREB regulated transcription coactivator 1	Mus musculus	255-261
27196770-1	2016	Inhibition of both the de novo (DNP) and salvage (NSP) pathways of nucleoside synthesis has been demonstrated to impair leukemia cells.	Nucleosides	67-77	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	50-53
27118477-4	2016	Herein, we report a nucleoside-based two-photon fluorescent rotor (dABp-3) that can selectively and ultrasensitively image microviscosity in RNA region of living cells for the first time.	Nucleosides	20-30	Disabled	Drosophila melanogaster	67-71
26906009-0	2016	Pharmacogenetic characterization of naturally occurring germline NT5C1A variants to chemotherapeutic nucleoside analogs.	Nucleosides	101-111	5'-nucleotidase, cytosolic IA	Homo sapiens	65-71
27009875-4	2016	Calcium-dependent human ENT1-CaM protein interactions were confirmed in human cell lines (HEK293, RT4, U-87 MG) using biochemical assays (HEK293) and the functional assays (HEK293, RT4), which confirmed modified nucleoside uptake that occurred in the presence of pharmacological manipulations of calcium levels and CaM function.	Nucleosides	212-222	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	24-28
27009875-7	2016	These data support the existence of a previously unidentified novel receptor-dependent regulatory mechanism, whereby intracellular calcium modulates nucleoside and NA drug uptake via CaM-dependent interaction of ENT1.	Nucleosides	149-159	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	212-216
26890707-5	2016	The lack of a C6 H-bond donor while maintaining A3AR affinity and efficacy could be rationalized by homology modeling and docking of these hypermodified nucleosides.	Nucleosides	153-164	adenosine A3 receptor	Homo sapiens	48-52
26970747-4	2016	For several kinds of model polar compounds, including organic acids, nucleosides, nucleic acid bases, amino acids, cephalosporins, and non-reducing sugars, PEI-Sil demonstrated excellent separation performance in terms of running stability, reproducibility, and separation efficiency (e.g., plate count ~74,000/m).	Nucleosides	69-80	STIL centriolar assembly protein	Homo sapiens	160-163
26489884-6	2016	In addition, modified nucleosides such as 7-methylguanosine, 8-hydroxyguanosine (8-OHG) and 8-hydroxydeoxyguanosine (8-OHdG) activated TLR7 with ORNs.	Nucleosides	22-33	toll like receptor 7	Homo sapiens	135-139
26081145-3	2016	ATP hydrolysis by ectonucleotidases is an important source of adenosine, and adenosine deaminase (ADA) contributes to the control of the nucleoside concentrations.	Nucleosides	137-147	adenosine deaminase	Danio rerio	77-96
26081145-3	2016	ATP hydrolysis by ectonucleotidases is an important source of adenosine, and adenosine deaminase (ADA) contributes to the control of the nucleoside concentrations.	Nucleosides	137-147	adenosine deaminase	Danio rerio	98-101
26577017-3	2016	Discussion on the role of the purine nucleosides transversally with the most established neurotrophic factors, e.g. brain derived neurotrophic factor (BDNF), glial derived neurotrophic factor (GDNF), is also focused considering the intimate relationship between some adenosine receptors, as is the case of the A2A receptors, and receptors for neurotrophins.	Nucleosides	37-48	brain derived neurotrophic factor	Homo sapiens	116-149
26857141-1	2016	A new reagent system consisting of a Lewis acid such as BF3 Et2O or Cu(OTf)2, the mild protic acid hexafluoroisopropanol and the reducing quenching agent triethylsilane was elaborated for O-, N- and S-detritylation of nucleoside, carbohydrate and amino acid derivatives.	Nucleosides	218-228	POU class 2 homeobox 2	Homo sapiens	68-76
26710791-11	2016	HUVECs from GDM pregnancies exhibit a differential requirement of A1AR or A2AAR depending on the level of insulin, a phenomenon that represent a condition where adenosine or analogues of this nucleoside could be acting as helpers of insulin biological effects in GDM.	Nucleosides	192-202	insulin	Homo sapiens	106-113
26813929-2	2016	Several nucleosides also enhanced [(3)H]mazindol [(+-)-5-(4-chlorophenyl)-3,5-dihydro-2H-imidazo[2,1-a]isoindol-5-ol] binding to the DAT.	Nucleosides	8-19	solute carrier family 6 member 3	Homo sapiens	133-136
27617063-1	2016	BACKGROUND: Adenosine, a signaling nucleoside, is controlled in part by the enzyme adenosine deaminase (ADA).	Nucleosides	35-45	adenosine deaminase	Homo sapiens	83-102
27617063-1	2016	BACKGROUND: Adenosine, a signaling nucleoside, is controlled in part by the enzyme adenosine deaminase (ADA).	Nucleosides	35-45	adenosine deaminase	Homo sapiens	104-107
26842729-2	2016	Based on previous studies implicating ABCC4/MRP4 in the transport of nucleosides, we hypothesized that cytarabine is sensitive to ABCC4-mediated efflux, thereby decreasing its cytotoxic response against AML blasts.	Nucleosides	69-80	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	38-43
26842729-2	2016	Based on previous studies implicating ABCC4/MRP4 in the transport of nucleosides, we hypothesized that cytarabine is sensitive to ABCC4-mediated efflux, thereby decreasing its cytotoxic response against AML blasts.	Nucleosides	69-80	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	44-48
26620371-1	2016	Deoxycytidine kinase (dCK) (EC 2.7.1.74) is a key enzyme for salvage of deoxynucleosides and activation of numerous anticancer and antiviral nucleoside analogs.	Nucleosides	77-87	deoxycytidine kinase	Homo sapiens	0-20
26620371-1	2016	Deoxycytidine kinase (dCK) (EC 2.7.1.74) is a key enzyme for salvage of deoxynucleosides and activation of numerous anticancer and antiviral nucleoside analogs.	Nucleosides	77-87	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
26621836-6	2016	In addition, supplement of nucleosides alone was sufficient to recover the growth defect mediated by BAG3 elevation.	Nucleosides	27-38	BAG cochaperone 3	Homo sapiens	101-105
26286663-6	2016	This review article describes the role of 1,2,4-triazole nucleus in different types of anti-cancer agents such as nucleoside based anti-cancer agents, kinase inhibitors, tubulin modulators, aromatase and steroid sulfatase inhibitors, methionine aminopeptidase inhibitors, tankyrase inhibitors and metal complex based anti-cancer agents.	Nucleosides	114-124	carboxypeptidase Q	Homo sapiens	245-259
26242695-3	2016	We recently developed a series of non-nucleoside non-competitive inhibitors of human adenosine kinase (hAK), based on a pyrrolobenzoxa(thia)zepinone scaffold.	Nucleosides	38-48	adenosine kinase	Homo sapiens	85-101
26242695-3	2016	We recently developed a series of non-nucleoside non-competitive inhibitors of human adenosine kinase (hAK), based on a pyrrolobenzoxa(thia)zepinone scaffold.	Nucleosides	38-48	alpha kinase 2	Homo sapiens	103-106
27458036-6	2016	XOR has an activating role that is essential to the pharmacological action of quinone drugs, cyadox, antiviral nucleoside analogues, allopurinol, nitrate and nitrite.	Nucleosides	111-121	xanthine dehydrogenase	Homo sapiens	0-3
26551065-4	2015	We present here an efficient method for the heterologous production and purification of EDN together with the synthesis of nucleosides and their biochemical evaluation in RNase A and EDN.	Nucleosides	123-134	ribonuclease A family member 2	Homo sapiens	88-91
26551065-4	2015	We present here an efficient method for the heterologous production and purification of EDN together with the synthesis of nucleosides and their biochemical evaluation in RNase A and EDN.	Nucleosides	123-134	ribonuclease A family member 1, pancreatic	Homo sapiens	171-178
26551065-4	2015	We present here an efficient method for the heterologous production and purification of EDN together with the synthesis of nucleosides and their biochemical evaluation in RNase A and EDN.	Nucleosides	123-134	ribonuclease A family member 2	Homo sapiens	183-186
25594111-1	2015	AIM: The factors associated with the outcome of sequential therapy with interferon-alpha (IFN-alpha) in order to halt nucleoside/nucleotide analog (NUC) maintenance treatment for chronic hepatitis B were analyzed.	Nucleosides	118-128	interferon alpha 1	Homo sapiens	90-99
26845980-0	2015	[Efficacy and safety of pegylated-IFN alpha sequential therapy at stopping nucleotide or nucleoside analogues in patients with hepatitis B under the analogue therapy].	Nucleosides	89-99	interferon alpha 1	Homo sapiens	34-43
27014060-4	2016	In isolated spontaneously beating rat atria, blockade of KCa2/SK channels with apamin and Cav1 (L-type) channels with nifedipine or verapamil, sensitized atria to the negative inotropic action of the A1 agonist, R-PIA, without affecting the nucleoside negative chronotropy.	Nucleosides	241-251	caveolin 1	Rattus norvegicus	90-94
26842729-2	2016	Based on previous studies implicating ABCC4/MRP4 in the transport of nucleosides, we hypothesized that cytarabine is sensitive to ABCC4-mediated efflux, thereby decreasing its cytotoxic response against AML blasts.	Nucleosides	69-80	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	130-135
26688730-2	2015	In beta-thalassemia major, where hemoglobin instability imposes oxidative stress, erythrocytes show reduced hENT1 nucleoside transporter expression and decreased nucleoside uptake.	Nucleosides	114-124	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	108-113
26710791-11	2016	HUVECs from GDM pregnancies exhibit a differential requirement of A1AR or A2AAR depending on the level of insulin, a phenomenon that represent a condition where adenosine or analogues of this nucleoside could be acting as helpers of insulin biological effects in GDM.	Nucleosides	192-202	insulin	Homo sapiens	233-240
26509218-9	2015	Because the nucleoside analogue is a poor phosphorylation substrate for human deoxycytidine kinase, a pro-nucleotide form of the 4-bromopyridone was used to incorporate this analogue into cellular DNA.	Nucleosides	12-22	deoxycytidine kinase	Homo sapiens	78-98
26579709-6	2015	We show, for the first time, that IDO mediates human tumor cell resistance to the candidate anticancer drugs FK866 (an NAD+ inhibitor), methoxyamine (MX, a base excision repair [BER] inhibitor) and approved anticancer drugs pemetrexed (a folate anti-metabolite) and gemcitabine (a nucleoside analogue), and combined treatment with pemetrexed and MX, in the absence of immune cells.	Nucleosides	281-291	indoleamine 2,3-dioxygenase 1	Homo sapiens	34-37
25909885-6	2015	Accordingly, for the first time we demonstrate that angustmycin A, a nucleoside-analog inhibitor of GMPS produced by Streptomyces hygroscopius efficiently suppresses melanoma cell invasion in vitro and tumorigenicity in immunocompromised mice.	Nucleosides	69-79	guanine monophosphate synthetase	Mus musculus	100-104
26455445-0	2015	Kinetico-mechanistic studies of substitution reactions on cross-bridged cyclen Co(III) complexes with nucleosides and nucleotides.	Nucleosides	102-113	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	79-86
26392572-4	2015	Enzyme kinetics and DNA-binding experiments demonstrate that HU enhances the 8-oxoguanine-DNA glycosylase activity of Fpg (formamidopyrimidine-DNA glycosylase) by facilitating the release of the enzyme from its final DNA product (one nucleoside gap).	Nucleosides	234-244	8-oxoguanine DNA glycosylase	Homo sapiens	77-105
26854454-6	2015	The second strongest mechanism was that rs16859886 modulates ADCY10 to affect its role in pathways including cyclase activity, phosphorus oxygen lyase activity, nucleobase, nucleoside, and nucleotide metabolic processing, and hsa00230 (0.010 <= p < 0.001; 0.038 <= FDR <= 0.016).	Nucleosides	173-183	adenylate cyclase 10	Homo sapiens	61-67
26496699-3	2015	The restrictive phenotype of myeloid cells can be alleviated through the direct degradation of SAMHD1 by the HIV-2/SIVSM Vpx protein or else, at least in the case of HIV-1, by the exogenous supplementation of nucleosides that artificially overcome the catabolic activity of SAMHD1 on dNTPs.	Nucleosides	209-220	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	95-101
26496699-3	2015	The restrictive phenotype of myeloid cells can be alleviated through the direct degradation of SAMHD1 by the HIV-2/SIVSM Vpx protein or else, at least in the case of HIV-1, by the exogenous supplementation of nucleosides that artificially overcome the catabolic activity of SAMHD1 on dNTPs.	Nucleosides	209-220	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	274-280
26431163-2	2015	Wee1 inhibitors cooperate with chemotherapeutics, e. g. nucleoside analogues, pushing malignant cells from S phase towards premature mitosis and death.	Nucleosides	56-66	WEE1 G2 checkpoint kinase	Homo sapiens	0-4
25980546-8	2015	Furthermore the nucleoside raised VEGF and decreased TNF-alpha levels, by activating A2B subtypes.	Nucleosides	16-26	vascular endothelial growth factor A	Mus musculus	34-38
25980546-8	2015	Furthermore the nucleoside raised VEGF and decreased TNF-alpha levels, by activating A2B subtypes.	Nucleosides	16-26	tumor necrosis factor	Mus musculus	53-62
25980546-8	2015	Furthermore the nucleoside raised VEGF and decreased TNF-alpha levels, by activating A2B subtypes.	Nucleosides	16-26	adenosine A2b receptor	Mus musculus	85-88
26431163-11	2015	We conclude that the pre-activation of p53 through Mdm2 antagonists serves as a viable option to selectively protect p53-proficient cells against the cytotoxic effects of Wee1 inhibitors, especially when combined with a nucleoside analogue.	Nucleosides	220-230	tumor protein p53	Homo sapiens	39-42
26431163-11	2015	We conclude that the pre-activation of p53 through Mdm2 antagonists serves as a viable option to selectively protect p53-proficient cells against the cytotoxic effects of Wee1 inhibitors, especially when combined with a nucleoside analogue.	Nucleosides	220-230	MDM2 proto-oncogene	Homo sapiens	51-55
26431163-11	2015	We conclude that the pre-activation of p53 through Mdm2 antagonists serves as a viable option to selectively protect p53-proficient cells against the cytotoxic effects of Wee1 inhibitors, especially when combined with a nucleoside analogue.	Nucleosides	220-230	WEE1 G2 checkpoint kinase	Homo sapiens	171-175
26352486-1	2015	Bacterial FPG (or MutM) is a bifunctional DNA glycosylase that is primarily responsible for excising 8-oxoguanine (OG) from the genome by cleaving the glycosidic bond and the DNA backbone at the 3"- and 5"-phosphates of the damaged nucleoside.	Nucleosides	232-242	8-oxoguanine DNA glycosylase	Homo sapiens	18-22
26455426-5	2015	In addition, SLC43A3 expressed in MDCKII cells mediated the uptake of purine nucleobases such as adenine, guanine, and hypoxanthine without requiring typical driving ions such as Na(+) and H(+), but it did not mediate the uptake of nucleosides.	Nucleosides	232-243	solute carrier family 43 member 3	Canis lupus familiaris	13-20
26337079-0	2015	NZ51, a ring-expanded nucleoside analog, inhibits motility and viability of breast cancer cells by targeting the RNA helicase DDX3.	Nucleosides	22-32	DEAD-box helicase 3 X-linked	Homo sapiens	126-130
26337079-2	2015	NZ51, a ring-expanded nucleoside analogue (REN) has been reported to inhibit the ATP dependent helicase activity of DDX3.	Nucleosides	22-32	DEAD-box helicase 3 X-linked	Homo sapiens	116-120
26179227-1	2015	In Saccharomyces cerevisiae, PHM8 encodes a phosphatase that catalyses the dephosphorylation of lysophosphatidic acids to monoacylglycerol and nucleotide monophosphate to nucleoside and releases free phosphate.	Nucleosides	171-181	bifunctional nucleotidase/lysophosphatidic acid phosphatase	Saccharomyces cerevisiae S288C	29-33
26163994-2	2015	ENT3 is a member of the equilibrative nucleoside transporter (ENT) family whose primary function is mediating transport of nucleosides and nucleobases.	Nucleosides	123-134	solute carrier family 29 member 3	Homo sapiens	0-4
25993322-7	2015	Systems integration revealed an unrecognized association between plasma RNASE1 and several RNA catabolites and modified nucleosides.	Nucleosides	120-131	ribonuclease A family member 1, pancreatic	Homo sapiens	72-78
26162242-1	2015	Human equilibrative nucleoside transporter-1 (hENT1) is the major plasma membrane transporter involved in transportation of natural nucleosides as well as nucleoside analog drugs, used in anti-cancer and anti-viral therapies.	Nucleosides	132-143	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
26134602-1	2015	Heterologous expression of the Drosophila melanogaster multi-substrate deoxyribonucleoside kinase (Dm-dNK) increases the sensitivity of cancer cells to several cytotoxic nucleoside analogs.	Nucleosides	80-90	deoxyribonucleoside kinase	Drosophila melanogaster	99-105
26038197-7	2015	Using the nucleoside analogue EdU (5-ethynyl-2"-deoxyuridine) as a marker of cell proliferation, application of alpha7*nAChR modulators in spinal cord cultures or in vivo induced proliferation in the CC region, producing Sox-2 expressing ependymal cells.	Nucleosides	10-20	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	112-124
26118338-2	2015	For the synthesis of the conjugates, C-5, C-2" and C-4"-tethered alkyne-modified nucleoside derivatives were used as an integral part of the standard automated oligonucleotide chain elongation.	Nucleosides	81-91	complement C4A (Rodgers blood group)	Homo sapiens	51-54
26390405-5	2015	Moreover, the nucleosides were able to induce apoptosis as measured by an increase in caspase 8 and caspase 3 activity above that of the control.	Nucleosides	14-25	caspase 8	Homo sapiens	86-95
26390405-5	2015	Moreover, the nucleosides were able to induce apoptosis as measured by an increase in caspase 8 and caspase 3 activity above that of the control.	Nucleosides	14-25	caspase 3	Homo sapiens	100-109
26390405-7	2015	Despite marginal changes to the mitochondrial membrane potential, all three nucleosides caused a significant increase in cytosolic cytochrome c (p>0.05), with a corresponding decrease in mitochondrial cytochrome c.	Nucleosides	76-87	cytochrome c, somatic	Homo sapiens	131-143
26390405-7	2015	Despite marginal changes to the mitochondrial membrane potential, all three nucleosides caused a significant increase in cytosolic cytochrome c (p>0.05), with a corresponding decrease in mitochondrial cytochrome c.	Nucleosides	76-87	cytochrome c, somatic	Homo sapiens	204-216
26210159-2	2015	An analysis of the conformational properties of the parent nucleosides was carried out using two-dimensional NMR spectroscopy based experiments, highlighting a 3"-endo (North) sugar puckering preference and syn orientation.	Nucleosides	59-70	synemin	Homo sapiens	207-210
26220519-0	2015	Design and synthesis of new non nucleoside inhibitors of DNMT3A.	Nucleosides	32-42	DNA methyltransferase 3 alpha	Homo sapiens	57-63
26188848-2	2015	MLL-rearranged infant ALL responds remarkably well to nucleoside analogue drugs in vitro, such as cytarabine and cladribine, and to the demethylating agents decitabine and zebularine as measured by cytotoxicity assays.	Nucleosides	54-64	lysine methyltransferase 2A	Homo sapiens	0-3
26188848-5	2015	Here we explored the in vitro potential of the novel nucleoside analogue clofarabine for MLL-rearranged infant ALL.	Nucleosides	53-63	lysine methyltransferase 2A	Homo sapiens	89-92
26462774-1	2015	OBJECTIVE: To investigate the expression level and analyze the clinical significance of NT5C2, which is an nucleoside analogues metabolism related gene, in children with acute leukemia (AL).	Nucleosides	107-117	5'-nucleotidase, cytosolic II	Homo sapiens	88-93
26200337-0	2015	CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer.	Nucleosides	37-48	cytidine deaminase	Homo sapiens	0-3
26118338-2	2015	For the synthesis of the conjugates, C-5, C-2" and C-4"-tethered alkyne-modified nucleoside derivatives were used as an integral part of the standard automated oligonucleotide chain elongation.	Nucleosides	81-91	complement C5	Homo sapiens	37-40
25244601-1	2015	AIM: Some patients develop hepatocellular carcinoma (HCC) during nucleoside/nucleotide analog (NA) therapy even if alanine aminotransferase (ALT) or hepatitis B virus (HBV) DNA levels are sufficiently reduced.	Nucleosides	65-75	glutamic--pyruvic transaminase	Homo sapiens	115-139
26079827-6	2015	Cells with decreased cN-II expression were resistant to the nucleoside analog fludarabine confirming the involvement of cN-II in the metabolism of this drug.	Nucleosides	60-70	5'-nucleotidase, cytosolic II	Homo sapiens	21-26
25403995-1	2015	Multidrug resistance protein 4 (MRP4) is involved in the efflux of nucleoside derivatives and has a role in the determination of drug sensitivity.	Nucleosides	67-77	ATP binding cassette subfamily C member 4	Homo sapiens	0-30
25403995-1	2015	Multidrug resistance protein 4 (MRP4) is involved in the efflux of nucleoside derivatives and has a role in the determination of drug sensitivity.	Nucleosides	67-77	ATP binding cassette subfamily C member 4	Homo sapiens	32-36
26162242-1	2015	Human equilibrative nucleoside transporter-1 (hENT1) is the major plasma membrane transporter involved in transportation of natural nucleosides as well as nucleoside analog drugs, used in anti-cancer and anti-viral therapies.	Nucleosides	20-30	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
26007660-4	2015	We report a 1.5 A crystal structure of aprataxin in a complex with GMP, which reveals that: (i) GMP binds at the same position and in the same anti nucleoside conformation as AMP; and (ii) aprataxin makes more extensive nucleobase contacts with guanine than with adenine, via a hydrogen bonding network to the guanine O6, N1, N2 base edge.	Nucleosides	148-158	aprataxin	Homo sapiens	39-48
26095193-4	2015	This nucleoside was incorporated into a mimic of the glutamate receptor B (GluR B) mRNA R/G editing site.	Nucleosides	5-15	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	53-73
26095193-4	2015	This nucleoside was incorporated into a mimic of the glutamate receptor B (GluR B) mRNA R/G editing site.	Nucleosides	5-15	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	75-81
26092110-7	2015	These nucleoside observations were then validated in oxidations of oligodeoxynucleotide and lambda-DNA contexts that demonstrated high yields of d2Ih in tandem with dOG, dSp, and dGh.	Nucleosides	6-16	dsp	Drosophila melanogaster	170-173
26041430-9	2015	The chromatographic performance of multiple EPGs containing C18 HILIC phases is illustrated by the separation of sulfa drugs, beta-blockers, xanthines, nucleic acid bases, nucleosides, and water-soluble vitamins.	Nucleosides	172-183	Bardet-Biedl syndrome 9	Homo sapiens	60-63
25377427-0	2015	Cardiomyocytes are Protected from Antiretroviral Nucleoside Analog-Induced Mitochondrial Toxicity by Overexpression of PGC-1alpha.	Nucleosides	49-59	PPARG coactivator 1 alpha	Sus scrofa	119-129
25998135-6	2015	On the other hand, expression of green fluorescent protein (GFP)-fused wild type or hyperactive mutant (R367Q) cN-II increased the activity and also decreased the sensitivity to nucleoside analogues.	Nucleosides	178-188	5'-nucleotidase, cytosolic II	Homo sapiens	111-116
26359022-3	2015	Four single nucleosides of VDR (Fok I, Bsm I, Apa I and Taq I) were genotyped by SNaPshot.	Nucleosides	12-23	vitamin D receptor	Homo sapiens	27-30
26102284-11	2015	Darunavir strongly induced expression in most cell lines of CNT3 involved in cell uptake of nucleotide/nucleoside analogue reverse transcriptase inhibitors and SLCO drug transporters involved in cell uptake of protease inhibitors.	Nucleosides	103-113	solute carrier family 28 member 3	Homo sapiens	60-64
25896650-3	2015	The resulting p.Glu391Lys variation in the last extracellular loop of the equilibrative nucleoside transporter 1 (ENT1; also called SLC29a1) is known not to alter its ability to transport nucleosides and nucleoside analog drugs.	Nucleosides	188-199	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	74-112
25896650-3	2015	The resulting p.Glu391Lys variation in the last extracellular loop of the equilibrative nucleoside transporter 1 (ENT1; also called SLC29a1) is known not to alter its ability to transport nucleosides and nucleoside analog drugs.	Nucleosides	88-98	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	114-118
25896650-3	2015	The resulting p.Glu391Lys variation in the last extracellular loop of the equilibrative nucleoside transporter 1 (ENT1; also called SLC29a1) is known not to alter its ability to transport nucleosides and nucleoside analog drugs.	Nucleosides	88-98	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	132-139
26041471-0	2015	Organometallic nucleosides induce non-classical leukemic cell death that is mitochondrial-ROS dependent and facilitated by TCL1-oncogene burden.	Nucleosides	15-26	TCL1 family AKT coactivator A	Homo sapiens	123-127
26070128-7	2015	ENT1 inhibitors may also affect the cellular transport, and hence the efficacy, of anticancer and antiviral nucleoside analogs used in chemotherapy.	Nucleosides	108-118	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	0-4
25656700-3	2015	In this paper we present evidence showing that, among the commonly used cytotoxic nucleoside analogs, fludarabine can act as a cN-II inhibitor.	Nucleosides	82-92	5'-nucleotidase, cytosolic II	Homo sapiens	127-132
25725289-1	2015	Equilibrative nucleoside transporter subtype 1 (ENT1) is critical for the regulation of the biological activities of endogenous nucleosides such as adenosine, and for the cellular uptake of chemotherapeutic nucleoside analogs.	Nucleosides	128-139	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	0-46
25725289-1	2015	Equilibrative nucleoside transporter subtype 1 (ENT1) is critical for the regulation of the biological activities of endogenous nucleosides such as adenosine, and for the cellular uptake of chemotherapeutic nucleoside analogs.	Nucleosides	128-139	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	48-52
25725289-1	2015	Equilibrative nucleoside transporter subtype 1 (ENT1) is critical for the regulation of the biological activities of endogenous nucleosides such as adenosine, and for the cellular uptake of chemotherapeutic nucleoside analogs.	Nucleosides	14-24	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	48-52
25761009-6	2015	Nucleoside and nucleotide models suggest that the anti and syn orientations about the glycosidic bond are isoenergetic for both adducts.	Nucleosides	0-10	synemin	Homo sapiens	59-62
25600708-2	2015	Human concentrative nucleoside transporter 1 (hCNT1) is implicated in sensitizing solid tumors to nucleoside analogs although its role in determining drug efficacy in ovarian cancers remains unclear.	Nucleosides	20-30	solute carrier family 28 member 1	Homo sapiens	46-51
25600708-10	2015	These findings uncover hCNT1 as a putative determinant for nucleoside analog chemoresistance in ovarian cancer and may help rationalize drug selection and delivery strategies for various histological subtypes of ovarian cancer.	Nucleosides	59-69	solute carrier family 28 member 1	Homo sapiens	23-28
25849562-5	2015	Enzymatic catabolism of salivary nucleosides reversed the SGE-induced immunosuppressive effect associated with IL-10 enhancement.	Nucleosides	33-44	interleukin 10	Mus musculus	111-116
25849562-8	2015	Treg induction (iTreg) was associated with nucleoside-induced tolerogenic dendritic cells (tDCs) expressing higher levels of COX2 and IL-10.	Nucleosides	43-53	cytochrome c oxidase II, mitochondrial	Mus musculus	125-129
25849562-8	2015	Treg induction (iTreg) was associated with nucleoside-induced tolerogenic dendritic cells (tDCs) expressing higher levels of COX2 and IL-10.	Nucleosides	43-53	interleukin 10	Mus musculus	134-139
25849562-10	2015	Suppressive effects of nucleosides during cutaneous leishmaniasis were mediated through an A2AR-dependent mechanism.	Nucleosides	23-34	adenosine A2a receptor	Mus musculus	91-95
25965828-1	2015	The therapeutic efficacy of nucleoside analogues, e.g. gemcitabine, against cancer cells can be augmented by inhibitors of checkpoint kinases, including Wee1, ATR, and Chk1.	Nucleosides	28-38	WEE1 G2 checkpoint kinase	Homo sapiens	153-157
25965828-1	2015	The therapeutic efficacy of nucleoside analogues, e.g. gemcitabine, against cancer cells can be augmented by inhibitors of checkpoint kinases, including Wee1, ATR, and Chk1.	Nucleosides	28-38	ATR serine/threonine kinase	Homo sapiens	159-162
25965828-1	2015	The therapeutic efficacy of nucleoside analogues, e.g. gemcitabine, against cancer cells can be augmented by inhibitors of checkpoint kinases, including Wee1, ATR, and Chk1.	Nucleosides	28-38	checkpoint kinase 1	Homo sapiens	168-172
25965828-7	2015	Taken together, these results confer a consistent signaling pathway reaching from Wee1 inhibition to impaired Chk1 activity, mechanistically dissecting how Wee1 inhibitors not only dysregulate cell cycle progression, but also enhance replicative stress and chemosensitivity towards nucleoside analogues.	Nucleosides	282-292	WEE1 G2 checkpoint kinase	Homo sapiens	82-86
25965828-7	2015	Taken together, these results confer a consistent signaling pathway reaching from Wee1 inhibition to impaired Chk1 activity, mechanistically dissecting how Wee1 inhibitors not only dysregulate cell cycle progression, but also enhance replicative stress and chemosensitivity towards nucleoside analogues.	Nucleosides	282-292	checkpoint kinase 1	Homo sapiens	110-114
25965828-7	2015	Taken together, these results confer a consistent signaling pathway reaching from Wee1 inhibition to impaired Chk1 activity, mechanistically dissecting how Wee1 inhibitors not only dysregulate cell cycle progression, but also enhance replicative stress and chemosensitivity towards nucleoside analogues.	Nucleosides	282-292	WEE1 G2 checkpoint kinase	Homo sapiens	156-160
25943135-0	2015	Kinetico-Mechanistic Studies of Nucleoside and Nucleotide Substitution Reactions of Co(III) Complexes of Fully Alkylated Cyclen.	Nucleosides	32-42	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	84-91
25749797-8	2015	This methodology has been applied to the quantitation of nucleosides and nucleoside triphosphates in primary human CD4 T lymphocytes and macrophages.	Nucleosides	57-68	CD4 molecule	Homo sapiens	115-118
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	Nucleosides	167-177	mitochondrial amidoxime reducing component 1	Homo sapiens	29-79
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	Nucleosides	167-177	mitochondrial amidoxime reducing component 2	Mus musculus	81-86
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	Nucleosides	167-177	mitochondrial amidoxime reducing component 2	Mus musculus	91-96
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	Nucleosides	167-177	cytochrome b5 type A	Homo sapiens	302-315
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	Nucleosides	167-177	cytochrome b5 type A	Homo sapiens	325-338
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	Nucleosides	233-244	mitochondrial amidoxime reducing component 1	Homo sapiens	29-79
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	Nucleosides	233-244	mitochondrial amidoxime reducing component 2	Mus musculus	81-86
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	Nucleosides	233-244	mitochondrial amidoxime reducing component 2	Mus musculus	91-96
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	Nucleosides	233-244	cytochrome b5 type A	Homo sapiens	302-315
25713076-4	2015	In vitro, the molybdoenzymes mitochondrial amidoxime reducing component 1 and 2 (mARC1 and mARC2) have shown to be capable of reducing N-hydroxylated base analogs and nucleoside analogs to the corresponding canonical nucleobases and nucleosides upon reconstitution with the electron transport proteins cytochrome b5 and NADH-cytochrome b5 reductase.	Nucleosides	233-244	cytochrome b5 type A	Homo sapiens	325-338
25713072-8	2015	siRNA knockdown experiments demonstrate that the nucleoside transporter, hENT1, plays a key role in the cellular entry of Ir(III)-PPY nucleoside.	Nucleosides	49-59	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	73-78
25830893-6	2015	Acetate (metabolized to acetyl-CoA, thereby substituting for the depleted FAO-derived acetyl-CoA) or a nucleoside mix rescued the phenotype of CPT1A-silenced endothelial cells.	Nucleosides	103-113	carnitine palmitoyltransferase 1a, liver	Mus musculus	143-148
25738457-0	2015	The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism.	Nucleosides	60-70	4-aminobutyrate aminotransferase	Homo sapiens	4-21
25738457-0	2015	The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism.	Nucleosides	60-70	4-aminobutyrate aminotransferase	Homo sapiens	23-27
25738457-2	2015	We report an essential role for ABAT in a seemingly unrelated pathway, mitochondrial nucleoside salvage, and demonstrate that mutations in this enzyme cause an autosomal recessive neurometabolic disorder and mtDNA depletion syndrome (MDS).	Nucleosides	85-95	4-aminobutyrate aminotransferase	Homo sapiens	32-36
25738457-4	2015	Nucleoside rescue and co-IP experiments pinpoint that ABAT functions in the mitochondrial nucleoside salvage pathway to facilitate conversion of dNDPs to dNTPs.	Nucleosides	0-10	4-aminobutyrate aminotransferase	Homo sapiens	54-58
25738457-4	2015	Nucleoside rescue and co-IP experiments pinpoint that ABAT functions in the mitochondrial nucleoside salvage pathway to facilitate conversion of dNDPs to dNTPs.	Nucleosides	90-100	4-aminobutyrate aminotransferase	Homo sapiens	54-58
25738457-6	2015	This work reveals ABAT as a connection between GABA metabolism and nucleoside metabolism and defines a neurometabolic disorder that includes MDS.	Nucleosides	67-77	4-aminobutyrate aminotransferase	Homo sapiens	18-22
25542974-7	2015	Interestingly, cpd 3, a nucleoside analog, induced a single resistant mutation in the P protein (D231V), indicating a novel mode of action not previously reported.	Nucleosides	24-34	spinocerebellar ataxia, autosomal recessive 2	Homo sapiens	15-20
25329362-8	2015	Prevention of the shut-off of host mRNA translation by nucleoside analogues is not due to the inhibition of eIF2alpha phosphorylation, as this prevention is also observed in PKR(-/-) mouse embryonic fibroblasts that do not phosphorylate eIF2alpha after SINV infection.	Nucleosides	55-65	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	174-177
25329362-8	2015	Prevention of the shut-off of host mRNA translation by nucleoside analogues is not due to the inhibition of eIF2alpha phosphorylation, as this prevention is also observed in PKR(-/-) mouse embryonic fibroblasts that do not phosphorylate eIF2alpha after SINV infection.	Nucleosides	55-65	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	237-246
25550158-11	2015	In addition, this mechanism was significant for drug development, as antagonization of RAR blocked infection of multiple HBV genotypes and also a clinically relevant HBV mutant that was resistant to nucleoside analogs.	Nucleosides	199-209	retinoic acid receptor alpha	Homo sapiens	87-90
25584790-10	2015	The influence of the formation of NA adducts on nucleoside conformation (particularly syn/anti orientation of the base) is also demonstrated on recent examples.	Nucleosides	48-58	synemin	Homo sapiens	86-89
25713533-4	2015	They translocate nucleosides in a Na(+) coupled manner with high affinity and some substrate selectivity, being hCNT1 and hCNT2 pyrimidine- and purine-preferring, respectively, and hCNT3 a broad selectivity transporter.	Nucleosides	17-28	solute carrier family 28 member 1	Homo sapiens	112-117
25713533-4	2015	They translocate nucleosides in a Na(+) coupled manner with high affinity and some substrate selectivity, being hCNT1 and hCNT2 pyrimidine- and purine-preferring, respectively, and hCNT3 a broad selectivity transporter.	Nucleosides	17-28	solute carrier family 28 member 2	Homo sapiens	122-127
25713533-4	2015	They translocate nucleosides in a Na(+) coupled manner with high affinity and some substrate selectivity, being hCNT1 and hCNT2 pyrimidine- and purine-preferring, respectively, and hCNT3 a broad selectivity transporter.	Nucleosides	17-28	solute carrier family 28 member 3	Homo sapiens	181-186
25713533-5	2015	SLC29 genes encode four members, being hENT1 and hENT2 the only two which are unequivocally implicated in the translocation of nucleosides and nucleobases (the latter mostly via hENT2) at the cell plasma membrane.	Nucleosides	127-138	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	39-44
25713533-5	2015	SLC29 genes encode four members, being hENT1 and hENT2 the only two which are unequivocally implicated in the translocation of nucleosides and nucleobases (the latter mostly via hENT2) at the cell plasma membrane.	Nucleosides	127-138	solute carrier family 29 member 2	Homo sapiens	49-54
25713533-5	2015	SLC29 genes encode four members, being hENT1 and hENT2 the only two which are unequivocally implicated in the translocation of nucleosides and nucleobases (the latter mostly via hENT2) at the cell plasma membrane.	Nucleosides	127-138	solute carrier family 29 member 2	Homo sapiens	178-183
25970912-1	2015	The interactions of bovine serum albumin (BSA) with five novel silicon (N) phthalocyanines(SiPcl-5) axially modified by nucleosides (cytidine, 5-N-cytidine, methyl cytidine, uridine and methyl uridine) derivatives were studied by fluorescence spectroscopy.	Nucleosides	120-131	albumin	Homo sapiens	27-40
25621025-3	2015	Our previous study identified a novel nucleoside analog that inhibited cellular growth and induced apoptosis in nasopharyngeal carcinoma (NPC) cell lines via downregulation of TIGAR expression.	Nucleosides	38-48	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	176-181
25593194-9	2015	Treating cells with the nucleoside analogue gemcitabine led to increased accumulation of single-stranded DNA upon G2E3 depletion, pointing to a defect in replication.	Nucleosides	24-34	G2/M-phase specific E3 ubiquitin protein ligase	Homo sapiens	114-118
25519698-9	2015	In clinical settings, TKI inhibitor concentrations in tumor tissues are sufficient to inhibit hENT1 activity, thereby reducing nucleoside chemotherapy drug levels in cancer cells and reducing efficacy in combination schedules.	Nucleosides	127-137	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	94-99
25468960-5	2015	RNA delivered to the vacuole was processed by Rny1, a T2-type ribonuclease, generating 3"-NMPs that were immediately converted to nucleosides by the vacuolar non-specific phosphatase Pho8.	Nucleosides	130-141	ribonuclease T2	Saccharomyces cerevisiae S288C	46-50
25468960-5	2015	RNA delivered to the vacuole was processed by Rny1, a T2-type ribonuclease, generating 3"-NMPs that were immediately converted to nucleosides by the vacuolar non-specific phosphatase Pho8.	Nucleosides	130-141	alkaline phosphatase PHO8	Saccharomyces cerevisiae S288C	183-187
25468960-6	2015	In the cytoplasm, these nucleosides were broken down by the nucleosidases Pnp1 and Urh1.	Nucleosides	24-35	purine-nucleoside phosphorylase	Saccharomyces cerevisiae S288C	74-78
25468960-6	2015	In the cytoplasm, these nucleosides were broken down by the nucleosidases Pnp1 and Urh1.	Nucleosides	24-35	trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase	Saccharomyces cerevisiae S288C	83-87
25462277-4	2015	The compound 36 had better cytotoxic activities (IC50 <= 1 muM) than the nucleobase 5-FU and nucleosides fludarabine, cladribine, and pentostatine on Huh7 cells.	Nucleosides	96-107	MIR7-3 host gene	Homo sapiens	153-157
26235575-2	2015	Decitabine (DAC), a DNA methyltransferase 1 inhibitor of nucleoside analogues, has been shown to restore gene expression silenced by hypermethylation.	Nucleosides	57-67	arylacetamide deacetylase	Homo sapiens	12-15
26235575-2	2015	Decitabine (DAC), a DNA methyltransferase 1 inhibitor of nucleoside analogues, has been shown to restore gene expression silenced by hypermethylation.	Nucleosides	57-67	DNA methyltransferase 1	Homo sapiens	20-43
25691808-7	2015	Rehabilitation of A2AR-mediated immune suppression and facilitation of transmitter release were observed by incubating the cells with the nucleoside precursor, AMP.	Nucleosides	138-148	adenosine A2a receptor	Rattus norvegicus	18-22
25310956-5	2015	The involvement of these signaling systems in the mechanism of the nucleoside action was strengthened by a reduction of the protective effect when glial cells were pretreated with U0126 or LY294002, the specific inhibitors of MEK1/2 and PI3K, respectively.	Nucleosides	67-77	mitogen activated protein kinase kinase 1	Rattus norvegicus	226-232
25182642-8	2014	These results suggest that downregulation of mitochondrial TK2 and dGK may lead to decreased mitochondrial DNA precursor pools and eventually mtDNA depletion, which has significant implications for the regulation of mitochondrial nucleotide biosynthesis and for antiviral therapy using nucleoside analogs.	Nucleosides	286-296	thymidine kinase 2	Homo sapiens	59-62
25333769-3	2014	A number of DNMT inhibitors have been reported, but most of them are nucleoside analogs that can lead to toxic side effects and lack specificity.	Nucleosides	69-79	DNA methyltransferase 1	Homo sapiens	12-16
26236460-3	2015	Docking of nucleosides containing possible short linker moieties at the adenine C2 position using a hybrid molecular model of the A3AR (based on the A2AAR agonist-bound structure) correctly predicted that a triazole would maintain the A3AR selectivity, due to its ability to fit a narrow cleft in the receptor.	Nucleosides	11-22	adenosine A3 receptor	Homo sapiens	130-134
26236460-3	2015	Docking of nucleosides containing possible short linker moieties at the adenine C2 position using a hybrid molecular model of the A3AR (based on the A2AAR agonist-bound structure) correctly predicted that a triazole would maintain the A3AR selectivity, due to its ability to fit a narrow cleft in the receptor.	Nucleosides	11-22	adenosine A3 receptor	Homo sapiens	235-239
25621702-5	2015	However, the synthesized nucleosides showed neither significant antiviral activity nor toxicity up to 50 muM.	Nucleosides	25-36	latexin	Homo sapiens	105-108
26252632-1	2015	Mitochondrial deoxyguanosine kinase (dGK), is an enzyme responsible for activation of nucleoside analogs (NAs) to phosphorylated compounds which exert profound cytotoxicity, especially in hematological malignancies.	Nucleosides	86-96	deoxyguanosine kinase	Homo sapiens	14-35
26252632-1	2015	Mitochondrial deoxyguanosine kinase (dGK), is an enzyme responsible for activation of nucleoside analogs (NAs) to phosphorylated compounds which exert profound cytotoxicity, especially in hematological malignancies.	Nucleosides	86-96	Diacyl glycerol kinase	Drosophila melanogaster	37-40
26252632-1	2015	Mitochondrial deoxyguanosine kinase (dGK), is an enzyme responsible for activation of nucleoside analogs (NAs) to phosphorylated compounds which exert profound cytotoxicity, especially in hematological malignancies.	Nucleosides	106-109	deoxyguanosine kinase	Homo sapiens	14-35
26252632-1	2015	Mitochondrial deoxyguanosine kinase (dGK), is an enzyme responsible for activation of nucleoside analogs (NAs) to phosphorylated compounds which exert profound cytotoxicity, especially in hematological malignancies.	Nucleosides	106-109	Diacyl glycerol kinase	Drosophila melanogaster	37-40
25674464-0	2014	Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine.	Nucleosides	73-83	ATP binding cassette subfamily C member 4	Homo sapiens	18-22
25674464-0	2014	Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine.	Nucleosides	73-83	ATP binding cassette subfamily C member 4	Homo sapiens	24-29
25674464-0	2014	Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine.	Nucleosides	73-83	ATP binding cassette subfamily C member 5	Homo sapiens	35-39
25674464-0	2014	Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine.	Nucleosides	73-83	ATP binding cassette subfamily C member 5	Homo sapiens	41-46
25372276-1	2014	Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) belongs to the family of ecto-nucleotidases, which control extracellular nucleotide, nucleoside, and (di)phosphate levels.	Nucleosides	139-149	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	0-46
25372276-1	2014	Nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) belongs to the family of ecto-nucleotidases, which control extracellular nucleotide, nucleoside, and (di)phosphate levels.	Nucleosides	139-149	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	48-52
24326379-8	2014	In this study, we demonstrated that nucleoside analogues decrease HGF through the suppression of hepatocyte damage, leading to the restoration of albumin production in patients with CH-B.	Nucleosides	36-46	hepatocyte growth factor	Homo sapiens	66-69
25080434-5	2014	Extracellular nucleotides and adenosine were shown to be rapidly metabolized on tumor cell surfaces via sequential ecto-5"-nucleotidase (CD73/NT5E) and adenosine deaminase reactions with subsequent cellular uptake of nucleoside metabolites and their intracellular interconversion into ADP/ATP.	Nucleosides	217-227	5'-nucleotidase ecto	Homo sapiens	137-141
25182642-8	2014	These results suggest that downregulation of mitochondrial TK2 and dGK may lead to decreased mitochondrial DNA precursor pools and eventually mtDNA depletion, which has significant implications for the regulation of mitochondrial nucleotide biosynthesis and for antiviral therapy using nucleoside analogs.	Nucleosides	286-296	Diacyl glycerol kinase	Drosophila melanogaster	67-70
25111583-0	2014	Synergistic cytotoxicity of sorafenib with busulfan and nucleoside analogs in human FMS-like tyrosine kinase 3 internal tandem duplications-positive acute myeloid leukemia cells.	Nucleosides	56-66	fms related receptor tyrosine kinase 3	Homo sapiens	84-110
25327705-5	2014	Tdp1"s list of substrates has since grown and can be divided into two groups: protein-DNA adducts, such as camptothecin stabilized Topo1-DNA adducts, and modified nucleotides, including oxidized nucleotides and chain terminating nucleoside analogs.	Nucleosides	229-239	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	0-4
25259627-1	2014	Adenosine kinase (ADK) from Mycobacterium tuberculosis (Mtb) was selected as a target for design of antimycobacterial nucleosides.	Nucleosides	118-129	adenosine kinase	Homo sapiens	0-16
25571722-1	2014	OBJECTIVE: To investigate the effect of human concentration nucleoside transporters 1 (hCNT1/ SLC28A1) and multi-drug resistance protein 4 (MRP4/ABCC4) gene polymorphism on the response of chronic hepatitis B patients to nucleoside analogues treatment.	Nucleosides	60-70	solute carrier family 28 member 1	Homo sapiens	87-92
25340302-0	2014	Formation of mixed-ligand complexes of Pd2+ with nucleoside 5"-monophosphates and some metal-ion-binding nucleoside surrogates.	Nucleosides	49-59	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	39-42
25340302-1	2014	Formation of mixed-ligand Pd2+ complexes between canonical nucleoside 5"-monophosphates and five metal-ion-binding nucleoside analogs has been studied by 1H-NMR spectroscopy to test the ability of these nucleoside surrogates to discriminate between unmodified nucleobases by Pd2+-mediated base pairing.	Nucleosides	59-69	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	26-29
25340302-1	2014	Formation of mixed-ligand Pd2+ complexes between canonical nucleoside 5"-monophosphates and five metal-ion-binding nucleoside analogs has been studied by 1H-NMR spectroscopy to test the ability of these nucleoside surrogates to discriminate between unmodified nucleobases by Pd2+-mediated base pairing.	Nucleosides	115-125	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	26-29
25739268-5	2014	The effects of the contents of water, salt concentration and pH on the retention of nucleosides and nucleic acid bases were respectively investigated, and the results indicated that Sil-IEASP is of hydrophilic interaction chromatographic nature.	Nucleosides	84-95	STIL centriolar assembly protein	Homo sapiens	182-185
25973142-9	2015	Comparison of rigid A3AR agonist congeners allows the exploration of interaction of specific regions of the nucleoside analogues with the target and off-target GPCRs, such as biogenic amine receptors.	Nucleosides	108-118	adenosine A3 receptor	Homo sapiens	20-24
25248077-4	2014	Therefore, we synthesized an orthosteric, photoisomerizable, and nonselective adenosine receptor agonist, nucleoside derivative MRS5543 containing an aryl diazo linkage on the N(6) substituent, which in the dark (relaxed isomer) behaved as a full adenosine A3 receptor (A3R) and partial adenosine A2A receptor (A2AR) agonist.	Nucleosides	106-116	adenosine A2a receptor	Homo sapiens	287-309
25248077-4	2014	Therefore, we synthesized an orthosteric, photoisomerizable, and nonselective adenosine receptor agonist, nucleoside derivative MRS5543 containing an aryl diazo linkage on the N(6) substituent, which in the dark (relaxed isomer) behaved as a full adenosine A3 receptor (A3R) and partial adenosine A2A receptor (A2AR) agonist.	Nucleosides	106-116	adenosine A2a receptor	Homo sapiens	311-315
25215937-5	2014	TK2 also phosphorylates a number of pyrimidine nucleoside analogues used in antiviral and anticancer therapy and thus plays an important role in mitochondrial toxicities caused by nucleoside analogues.	Nucleosides	47-57	thymidine kinase 2	Homo sapiens	0-3
24234349-2	2014	The enzyme is responsible for the dephosphorylation of physiological substrates as well as nucleoside analogues that are used in antiviral and anticancer therapies, therefore selective inhibition of the dNT-1 nucleotidase activity may lead to an increase in efficacy of this type of therapeutic compounds.	Nucleosides	91-101	Neurotrophin 1	Drosophila melanogaster	203-208
25000516-1	2014	AIMS: The cytosolic 5"-nucleotidase-III (NT5C3) is involved in the metabolism of the nucleoside analog, cytosine arabinose (AraC), and the expression level of NT5C3 is correlated with sensitivity to AraC in acute myeloid leukemia (AML) patients.	Nucleosides	85-95	5'-nucleotidase, cytosolic IIIA	Homo sapiens	41-46
25145319-1	2014	An aptamer specifically binding the interleukin-6 receptor and intrinsically comprising multiple units of the nucleoside analogue 5-fluoro-2"-deoxyuridine can exert a cytostatic effect direcly on certain cells presenting the receptor.	Nucleosides	110-120	interleukin 6 receptor	Homo sapiens	36-58
24788480-2	2014	Given the role of hENT1 in the transport of nucleoside drugs, an important class of therapeutics in the treatment of various cancers and viral infections, efforts have been made to better understand the mechanisms by which hENT1 modulates nucleoside transport.	Nucleosides	44-54	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	18-23
24788480-2	2014	Given the role of hENT1 in the transport of nucleoside drugs, an important class of therapeutics in the treatment of various cancers and viral infections, efforts have been made to better understand the mechanisms by which hENT1 modulates nucleoside transport.	Nucleosides	44-54	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	223-228
24788480-2	2014	Given the role of hENT1 in the transport of nucleoside drugs, an important class of therapeutics in the treatment of various cancers and viral infections, efforts have been made to better understand the mechanisms by which hENT1 modulates nucleoside transport.	Nucleosides	239-249	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	223-228
25125220-1	2014	A group of acidic nucleosides were synthesized to develop a new class of ribonuclease A (RNase A) inhibitors.	Nucleosides	18-29	ribonuclease A family member 1, pancreatic	Homo sapiens	73-87
25125220-1	2014	A group of acidic nucleosides were synthesized to develop a new class of ribonuclease A (RNase A) inhibitors.	Nucleosides	18-29	ribonuclease A family member 1, pancreatic	Homo sapiens	89-96
25000516-1	2014	AIMS: The cytosolic 5"-nucleotidase-III (NT5C3) is involved in the metabolism of the nucleoside analog, cytosine arabinose (AraC), and the expression level of NT5C3 is correlated with sensitivity to AraC in acute myeloid leukemia (AML) patients.	Nucleosides	85-95	5'-nucleotidase, cytosolic IIIA	Homo sapiens	159-164
24908436-0	2014	Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4"-thio-2"-deoxycytidine and 5-aza-4"-thio-2"-deoxycytidine.	Nucleosides	59-70	DNA methyltransferase 1	Homo sapiens	6-29
24908436-0	2014	Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4"-thio-2"-deoxycytidine and 5-aza-4"-thio-2"-deoxycytidine.	Nucleosides	59-70	DNA methyltransferase 1	Homo sapiens	31-36
24908436-1	2014	PURPOSE: Currently approved DNA hypomethylating nucleosides elicit their effects in part by depleting DNA methyltransferase I (DNMT1).	Nucleosides	48-59	DNA methyltransferase 1	Homo sapiens	127-132
24749746-3	2014	Using mass spectrometry, we measured nucleoside production by subsets of human CD4(+) CD39(+) and CD4(+) CD39(-)CD73(+) T cells or CD19(+) B cells isolated from blood of 30 volunteers and 14 cancer patients.	Nucleosides	37-47	CD4 molecule	Homo sapiens	79-82
24749746-3	2014	Using mass spectrometry, we measured nucleoside production by subsets of human CD4(+) CD39(+) and CD4(+) CD39(-)CD73(+) T cells or CD19(+) B cells isolated from blood of 30 volunteers and 14 cancer patients.	Nucleosides	37-47	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	86-90
24749746-3	2014	Using mass spectrometry, we measured nucleoside production by subsets of human CD4(+) CD39(+) and CD4(+) CD39(-)CD73(+) T cells or CD19(+) B cells isolated from blood of 30 volunteers and 14 cancer patients.	Nucleosides	37-47	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	105-109
24749746-3	2014	Using mass spectrometry, we measured nucleoside production by subsets of human CD4(+) CD39(+) and CD4(+) CD39(-)CD73(+) T cells or CD19(+) B cells isolated from blood of 30 volunteers and 14 cancer patients.	Nucleosides	37-47	5'-nucleotidase ecto	Homo sapiens	112-116
24928506-4	2014	We screened five libraries of ~ 3000 small molecules, including one comprising ~ 600 nucleoside analogs, for their effect on primer extension activity of DNA polymerase eta (Pol eta).	Nucleosides	85-95	DNA polymerase eta	Homo sapiens	154-172
24928506-4	2014	We screened five libraries of ~ 3000 small molecules, including one comprising ~ 600 nucleoside analogs, for their effect on primer extension activity of DNA polymerase eta (Pol eta).	Nucleosides	85-95	endothelin receptor type A	Homo sapiens	169-172
29699354-0	2014	Nucleoside Analog-treated Chronic Hepatitis B Patients showed Reduced Expression of PECAM-1 Gene in Peripheral Blood Mononuclear Cells in Bangladesh.	Nucleosides	0-10	platelet and endothelial cell adhesion molecule 1	Homo sapiens	84-91
24976360-5	2014	Both cell types displayed similar transporter expression profiles, with the majority (>90%) of 2-chloro[(3)H]adenosine (nucleoside) uptake mediated by ENT1 and [(3)H]hypoxanthine (nucleobase) uptake mediated by ENBT1.	Nucleosides	123-133	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	154-158
24976398-0	2014	Down-regulation of mitochondrial thymidine kinase 2 and deoxyguanosine kinase by didanosine: implication for mitochondrial toxicities of anti-HIV nucleoside analogs.	Nucleosides	146-156	thymidine kinase 2	Homo sapiens	33-51
24976398-6	2014	The results suggest that down-regulation of mitochondrial TK2 and dGK may be a mechanism of mitochondrial toxicity caused by antiviral and anticancer nucleoside analogs.	Nucleosides	150-160	thymidine kinase 2	Homo sapiens	58-61
24976398-6	2014	The results suggest that down-regulation of mitochondrial TK2 and dGK may be a mechanism of mitochondrial toxicity caused by antiviral and anticancer nucleoside analogs.	Nucleosides	150-160	Diacyl glycerol kinase	Drosophila melanogaster	66-69
24858469-1	2014	A new hydrophilic and nonionic poly(2-vinyloxazoline)-grafted silica (Sil-VOX(n)) phase was synthesized and applied for the separation of nucleosides and nucleobases in hydrophilic interaction chromatography (HILIC).	Nucleosides	138-149	STIL centriolar assembly protein	Homo sapiens	70-73
24747042-8	2014	In conclusion, clinical ACV-resistant HSV-1 isolates, carrying resistance-associated mutations in the TK gene, can be regarded as cross-resistant to other nucleoside analogs such as BVDU.	Nucleosides	155-165	involved in nucleotide metabolism	Human alphaherpesvirus 1	102-104
29699354-10	2014	Nucleoside Analog-treated Chronic Hepatitis B Patients showed Reduced Expression of PECAM-1 Gene in Peripheral Blood Mononuclear Cells in Bangladesh.	Nucleosides	0-10	platelet and endothelial cell adhesion molecule 1	Homo sapiens	84-91
24870241-8	2014	Normal T-cell proliferation was restored in CTPS1-deficient cells by expressing wild-type CTPS1 or by addition of exogenous CTP or its nucleoside precursor, cytidine.	Nucleosides	135-145	CTP synthase 1	Homo sapiens	44-49
24972933-0	2014	Downregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents.	Nucleosides	118-128	deoxycytidine kinase	Homo sapiens	18-38
24972933-13	2014	CONCLUSIONS: Acquired resistance of MCL cells to araC is associated with downregulation of DCK, enzyme of the nucleotide salvage pathway responsible for the first phosphorylation (=activation) of most nucleoside analogs used in anti-cancer therapy.	Nucleosides	201-211	deoxycytidine kinase	Homo sapiens	91-94
24531536-7	2014	Genome-wide gene expression analysis and nucleoside and nucleotide profiling revealed that knockdown of ENPP1 affects purine and pyrimidine metabolism, suggesting a link between ENPP1 expression and a balanced nucleoside-nucleotide pool in GSCs.	Nucleosides	41-51	ectonucleotide pyrophosphatase/phosphodiesterase 1	Homo sapiens	104-109
26579384-1	2014	Multidrug resistance protein 7 (MRP7, ABCC10) is a recently identified member of the ATP-binding cassette (ABC) transporter family, which adequately confers resistance to a diverse group of antineoplastic agents, including taxanes, vinca alkaloids and nucleoside analogs among others.	Nucleosides	252-262	ATP binding cassette subfamily C member 10	Homo sapiens	0-30
26579384-1	2014	Multidrug resistance protein 7 (MRP7, ABCC10) is a recently identified member of the ATP-binding cassette (ABC) transporter family, which adequately confers resistance to a diverse group of antineoplastic agents, including taxanes, vinca alkaloids and nucleoside analogs among others.	Nucleosides	252-262	ATP binding cassette subfamily C member 10	Homo sapiens	32-36
26579384-1	2014	Multidrug resistance protein 7 (MRP7, ABCC10) is a recently identified member of the ATP-binding cassette (ABC) transporter family, which adequately confers resistance to a diverse group of antineoplastic agents, including taxanes, vinca alkaloids and nucleoside analogs among others.	Nucleosides	252-262	ATP binding cassette subfamily C member 10	Homo sapiens	38-44
24705959-9	2014	Ten nucleosides and bases were separated, using only water as the mobile phase, within a very short time using the Sil-poly(ImC18-AAL), which is otherwise difficult to achieve using conventional hydrophobic columns such as ODS.	Nucleosides	4-15	STIL centriolar assembly protein	Homo sapiens	115-118
24667336-2	2014	The amino acid substitution H208Y shows increased prevalence in patients treated with nucleoside analogues and is frequently associated with TAM1 mutations.	Nucleosides	86-96	stromal interaction molecule 1	Homo sapiens	141-145
24767447-1	2014	We report on the generation and analytical application of the monoclonal antibody G93-ED2 raised against the tricyclic fluorescent nucleoside analogue 1,3-diaza-2-oxophenoxazine (tC ).	Nucleosides	131-141	gap junction protein beta 6	Homo sapiens	86-89
24686197-1	2014	Homotrimeric mammalian purine nucleoside phosphorylase (PNP) plays a key role in the nucleoside and nucleotide metabolic salvage pathway.	Nucleosides	30-40	purine nucleoside phosphorylase	Homo sapiens	56-59
24759867-1	2014	OBJECTIVES: Intra-individual spatial overlap analysis of tumor volumes assessed by MRI, the amino acid PET tracer [18F]-FET and the nucleoside PET tracer [18F]-FLT in high-grade gliomas (HGG).	Nucleosides	132-142	fms related receptor tyrosine kinase 1	Homo sapiens	160-163
24947531-2	2014	BACKGROUND: Protease inhibitor (PI) monotherapy for treatment could avoid the adverse events, drug resistance, and additional costs associated with other antiretrovirals that are normally used, particularly the nucleoside analogues.	Nucleosides	211-221	serpin family A member 13, pseudogene	Homo sapiens	12-30
24947531-2	2014	BACKGROUND: Protease inhibitor (PI) monotherapy for treatment could avoid the adverse events, drug resistance, and additional costs associated with other antiretrovirals that are normally used, particularly the nucleoside analogues.	Nucleosides	211-221	serpin family A member 13, pseudogene	Homo sapiens	32-34
24670650-4	2014	P2Y12R regulates platelet activation and thrombus formation, and several antithrombotic drugs targeting P2Y12R--including the prodrugs clopidogrel (Plavix) and prasugrel (Effient) that are metabolized and bind covalently, and the nucleoside analogue ticagrelor (Brilinta) that acts directly on the receptor--have been approved for the prevention of stroke and myocardial infarction.	Nucleosides	230-240	purinergic receptor P2Y12	Homo sapiens	0-6
24607586-1	2014	The cytosolic 5"-nucleotidase II (cN-II) has been proposed as an attractive molecular target for the development of novel drugs circumventing resistance to cytotoxic nucleoside analogues currently used for treating leukemia and other malignant hemopathies.	Nucleosides	166-176	5'-nucleotidase, cytosolic II	Homo sapiens	4-32
24607586-1	2014	The cytosolic 5"-nucleotidase II (cN-II) has been proposed as an attractive molecular target for the development of novel drugs circumventing resistance to cytotoxic nucleoside analogues currently used for treating leukemia and other malignant hemopathies.	Nucleosides	166-176	5'-nucleotidase, cytosolic II	Homo sapiens	34-39
24735592-1	2014	OBJECTIVE: To evaluate the efficacy and safety of the magnesium isoglycyrrhizinate plus nucleoside analogues (MGL + NA) combination therapy in patients with chronic hepatitis B using a meta-analysis approach.	Nucleosides	88-98	monoglyceride lipase	Homo sapiens	110-113
24604285-2	2014	Pursuing our studies on selective BChE inhibitors, that may contribute to understand the role of this enzyme in disease progression, we present now microwave-assisted synthesis and anticholinesterase activity of a new nucleoside series embodying 6-chloropurine or 2-acetamido-6-chloropurine linked to D-glucosyl, D-galactosyl and D-mannosyl residues.	Nucleosides	218-228	butyrylcholinesterase	Homo sapiens	34-38
24604285-6	2014	Some of the nucleosides were far more potent than the drug galantamine, and the most promising competitive and selective BChE inhibitor, the N(7)-linked 2-acetamido-alpha-D-mannosylpurine, showed a Ki of 50 nM and a selectivity factor of 340 fold for BChE over AChE.	Nucleosides	12-23	butyrylcholinesterase	Homo sapiens	121-125
24604285-6	2014	Some of the nucleosides were far more potent than the drug galantamine, and the most promising competitive and selective BChE inhibitor, the N(7)-linked 2-acetamido-alpha-D-mannosylpurine, showed a Ki of 50 nM and a selectivity factor of 340 fold for BChE over AChE.	Nucleosides	12-23	butyrylcholinesterase	Homo sapiens	251-255
24604285-6	2014	Some of the nucleosides were far more potent than the drug galantamine, and the most promising competitive and selective BChE inhibitor, the N(7)-linked 2-acetamido-alpha-D-mannosylpurine, showed a Ki of 50 nM and a selectivity factor of 340 fold for BChE over AChE.	Nucleosides	12-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	261-265
24467396-8	2014	DCTPP1-deficient cells accumulate high levels of dCTP and are hypersensitive to exposure to the nucleoside analogues 5-iodo-2"-deoxycytidine and 5-methyl-2"-deoxycytidine.	Nucleosides	96-106	dCTP pyrophosphatase 1	Homo sapiens	0-6
24372395-9	2014	Oral nucleoside analogue therapies can suppress fibrosis and reduce HCC incidence by successfully reversing phosphorylated Smad3 signalling; even liver disease progressed to cirrhosis in chronic hepatitis B patients.	Nucleosides	5-15	SMAD family member 3	Homo sapiens	123-128
24812435-10	2014	Therefore, we treated RP-deficient zebrafish embryos with exogenous nucleosides and observed decreased activation of p53 and AMPK, reduced apoptosis, and rescue of hematopoiesis.	Nucleosides	68-79	tumor protein p53	Danio rerio	117-120
24856239-3	2014	TDP1 not only excises trapped topoisomerases I (Top1 in the nucleus and Top1mt in mitochondria), but also repairs oxidative damage-induced 3"-phosphoglycolates and alkylation damage-induced DNA breaks, and excises chain terminating anticancer and antiviral nucleosides in the nucleus and mitochondria.	Nucleosides	257-268	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	0-4
24436471-3	2014	Multidrug resistance protein 4 (MRP4) is an ATP binding cassette transporter that mediates the efflux of organic molecules, such as nucleoside analogs, in the gastrointestinal and renal epithelia.	Nucleosides	132-142	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	0-30
24436471-3	2014	Multidrug resistance protein 4 (MRP4) is an ATP binding cassette transporter that mediates the efflux of organic molecules, such as nucleoside analogs, in the gastrointestinal and renal epithelia.	Nucleosides	132-142	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	32-36
24436471-6	2014	When expressed in HEK293 cells, NHERF3 increased membrane expression of MRP4 by reducing internalization of cell surface MRP4 and consequently, augmented MRP4-mediated efflux of adefovir, a nucleoside-based antiviral agent and well known substrate of MRP4.	Nucleosides	190-200	PDZ domain containing 1	Homo sapiens	32-38
24436471-6	2014	When expressed in HEK293 cells, NHERF3 increased membrane expression of MRP4 by reducing internalization of cell surface MRP4 and consequently, augmented MRP4-mediated efflux of adefovir, a nucleoside-based antiviral agent and well known substrate of MRP4.	Nucleosides	190-200	ATP binding cassette subfamily C member 4	Homo sapiens	72-76
24436471-6	2014	When expressed in HEK293 cells, NHERF3 increased membrane expression of MRP4 by reducing internalization of cell surface MRP4 and consequently, augmented MRP4-mediated efflux of adefovir, a nucleoside-based antiviral agent and well known substrate of MRP4.	Nucleosides	190-200	ATP binding cassette subfamily C member 4	Homo sapiens	121-125
24436471-6	2014	When expressed in HEK293 cells, NHERF3 increased membrane expression of MRP4 by reducing internalization of cell surface MRP4 and consequently, augmented MRP4-mediated efflux of adefovir, a nucleoside-based antiviral agent and well known substrate of MRP4.	Nucleosides	190-200	ATP binding cassette subfamily C member 4	Homo sapiens	121-125
24436471-6	2014	When expressed in HEK293 cells, NHERF3 increased membrane expression of MRP4 by reducing internalization of cell surface MRP4 and consequently, augmented MRP4-mediated efflux of adefovir, a nucleoside-based antiviral agent and well known substrate of MRP4.	Nucleosides	190-200	ATP binding cassette subfamily C member 4	Homo sapiens	121-125
24664100-1	2014	CD73 catalyzes the conversion of extracellular nucleosides to adenosine, modulating inflammatory and T cell responses.	Nucleosides	47-58	5' nucleotidase, ecto	Mus musculus	0-4
24462681-1	2014	Deoxycytidine kinase (dCK) is a critical enzyme for activation of anticancer nucleoside analogs.	Nucleosides	77-87	deoxycytidine kinase	Homo sapiens	0-20
24462681-1	2014	Deoxycytidine kinase (dCK) is a critical enzyme for activation of anticancer nucleoside analogs.	Nucleosides	77-87	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
24557113-0	2014	Mechanical allodynia induced by nucleoside reverse transcriptase inhibitor is suppressed by p55TNFSR mediated by herpes simplex virus vector through the SDF1alpha/CXCR4 system in rats.	Nucleosides	32-42	C-X-C motif chemokine receptor 4	Rattus norvegicus	163-168
24170810-6	2014	We demonstrate the utility of the assay by screening a chemical compound library, resulting in the identification of non-nucleoside inhibitors of the Caf1/CNOT7 enzyme, a catalytic subunit of the Ccr4-Not deadenylase complex.	Nucleosides	121-131	CCR4-NOT transcription complex subunit 7	Homo sapiens	150-154
24170810-6	2014	We demonstrate the utility of the assay by screening a chemical compound library, resulting in the identification of non-nucleoside inhibitors of the Caf1/CNOT7 enzyme, a catalytic subunit of the Ccr4-Not deadenylase complex.	Nucleosides	121-131	CCR4-NOT transcription complex subunit 7	Homo sapiens	155-160
24461293-2	2014	Examples of ring-expanded nucleosides (RENs), represented by general structures 1 and 2, exhibited dual anti-HCV and anti-HIV activities in both cell culture systems and the respective target enzyme assays, including HCV NTPase/helicase and human RNA helicase DDX3.	Nucleosides	26-37	helicase for meiosis 1	Homo sapiens	228-236
24461293-2	2014	Examples of ring-expanded nucleosides (RENs), represented by general structures 1 and 2, exhibited dual anti-HCV and anti-HIV activities in both cell culture systems and the respective target enzyme assays, including HCV NTPase/helicase and human RNA helicase DDX3.	Nucleosides	26-37	helicase for meiosis 1	Homo sapiens	251-259
24461293-2	2014	Examples of ring-expanded nucleosides (RENs), represented by general structures 1 and 2, exhibited dual anti-HCV and anti-HIV activities in both cell culture systems and the respective target enzyme assays, including HCV NTPase/helicase and human RNA helicase DDX3.	Nucleosides	26-37	DEAD-box helicase 3 X-linked	Homo sapiens	260-264
24505337-3	2014	In contrast to "pathogenic" Th17, supTh17 display immune suppressive function and express high levels of CD39, an ectonucleotidase that catalyzes the conversion of pro-inflammatory extracellular nucleotides ultimately generating nucleosides.	Nucleosides	229-240	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	105-109
24140360-1	2014	Two nontypical nucleosides, 7-beta-D-ribosyl-2,6-diamino-8-azapurine and 8-beta-D-ribosyl-2,6-diamino-8-azapurine, have been found to exhibit moderately good, and selective, substrate properties toward calf and bacterial (Escherichia coli) forms of purine nucleoside phosphorylase (PNP).	Nucleosides	15-26	purine nucleoside phosphorylase	Homo sapiens	249-280
24140360-1	2014	Two nontypical nucleosides, 7-beta-D-ribosyl-2,6-diamino-8-azapurine and 8-beta-D-ribosyl-2,6-diamino-8-azapurine, have been found to exhibit moderately good, and selective, substrate properties toward calf and bacterial (Escherichia coli) forms of purine nucleoside phosphorylase (PNP).	Nucleosides	15-26	purine nucleoside phosphorylase	Bos taurus	282-285
24362350-0	2014	Amino and carboxy functionalized modified nucleosides: a potential class of inhibitors for angiogenin.	Nucleosides	42-53	angiogenin	Homo sapiens	91-101
24362350-4	2014	The chorioallantoic membrane (CAM) assay qualitatively suggests that amino functionalized nucleosides have an effective potency to inhibited angiogenin-induced angiogenesis.	Nucleosides	90-101	angiogenin	Homo sapiens	141-151
24419380-1	2014	Deoxycytidine kinase (dCK) is a key enzyme in the nucleoside salvage pathway that is also required for the activation of several anticancer and antiviral nucleoside analog prodrugs.	Nucleosides	154-164	deoxycytidine kinase	Homo sapiens	0-20
24419380-1	2014	Deoxycytidine kinase (dCK) is a key enzyme in the nucleoside salvage pathway that is also required for the activation of several anticancer and antiviral nucleoside analog prodrugs.	Nucleosides	50-60	deoxycytidine kinase	Homo sapiens	0-20
24419380-1	2014	Deoxycytidine kinase (dCK) is a key enzyme in the nucleoside salvage pathway that is also required for the activation of several anticancer and antiviral nucleoside analog prodrugs.	Nucleosides	50-60	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
25034284-11	2014	Increased understanding of mechanisms of extracellular ATP scavenging and specifically conversion to nucleosides by ectonucleotidases of the CD39 family have also led to novel insights into the exquisite balance of nucleotide P2-receptor and adenosinergic P1-receptor signaling in inflammatory and hepatic diseases.	Nucleosides	101-112	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	141-145
24355542-3	2014	Thus, TDP1 is regarded as a determinant of resistance to Top1 inhibitors and chain terminating nucleosides, and possibly of genomic stability.	Nucleosides	95-106	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	6-10
24522200-1	2014	Human equilibrative nucleoside transporter 1 (hENT1) transports various nucleoside analogues into cells.	Nucleosides	20-30	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
24419380-1	2014	Deoxycytidine kinase (dCK) is a key enzyme in the nucleoside salvage pathway that is also required for the activation of several anticancer and antiviral nucleoside analog prodrugs.	Nucleosides	154-164	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
24419380-5	2014	The structures reveal that the compounds occupy the nucleoside-binding site and bind to the open form of dCK.	Nucleosides	52-62	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	105-108
23731482-0	2014	Molecular structure differences between the antiviral Nucleoside Analogue 5-iodo-2"-deoxyuridine and the natural nucleoside 2"-deoxythymidine using MP2 and DFT methods: conformational analysis, crystal simulations, DNA pairs and possible behaviour.	Nucleosides	54-64	tryptase pseudogene 1	Homo sapiens	148-151
24163005-0	2014	The adenosine transporter, ENT1, in cardiomyocytes is sensitive to inhibition by ethanol in a kinase-dependent manner: implications for ethanol-dependent cardioprotection and nucleoside analog drug cytotoxicity.	Nucleosides	175-185	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	27-31
24163005-1	2014	The adenosine transporter 1 (ENT1) transports nucleosides, such as adenosine, and cytotoxic nucleoside analog drugs.	Nucleosides	46-57	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	29-33
24163005-1	2014	The adenosine transporter 1 (ENT1) transports nucleosides, such as adenosine, and cytotoxic nucleoside analog drugs.	Nucleosides	46-56	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	29-33
24163005-7	2014	These data suggest that the presence of ethanol may compromise ENT1-dependent nucleoside analog drug cytotoxicity, and indeed, ethanol (5 mM) reduces the cytotoxic effects of gemcitabine (2 nM), an anti-cancer drug, in the human cancer cell line, HTB2.	Nucleosides	78-88	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	63-67
24264248-6	2014	Furthermore, ecto-nucleotidases are also involved in the purine salvage pathway, acting in the generation of nucleosides that are able to cross plasma membrane via specialized transporters.	Nucleosides	109-120	tripartite motif containing 33	Homo sapiens	13-17
24138566-1	2013	cAMP receptor protein (CRP) and CytR mediate positive and negative control of nine genes in Escherichia coli, most of which are involved in nucleoside catabolism and recycling.	Nucleosides	140-150	catabolite gene activator protein	Escherichia coli	0-21
24202179-6	2013	We also show increased binding of the transcription factor, USF2, to oligonucleotide containing nucleoside -214A as opposed to -214C.	Nucleosides	96-106	upstream transcription factor 2	Mus musculus	60-64
24288262-0	2013	Enzymatic interconversion of isomorphic fluorescent nucleosides: adenosine deaminase transforms an adenosine analogue into an inosine analogue.	Nucleosides	52-63	adenosine deaminase	Homo sapiens	65-84
24033540-3	2013	We found that a nucleoside analog (Ly101-4B) elicits efficient inhibition on HSF1 expression and potent anticancer activity on epithelial ovarian cancer both in vitro and in vivo.	Nucleosides	16-26	heat shock transcription factor 1	Homo sapiens	77-81
24138566-1	2013	cAMP receptor protein (CRP) and CytR mediate positive and negative control of nine genes in Escherichia coli, most of which are involved in nucleoside catabolism and recycling.	Nucleosides	140-150	catabolite gene activator protein	Escherichia coli	23-26
23816837-12	2013	The information obtained from the crystal structure of human GMPS might therefore aid in understanding interactions of nucleoside-based drugs with GMPS and in structure-based design of GMPS-specific inhibitors.	Nucleosides	119-129	guanine monophosphate synthase	Homo sapiens	61-65
23816837-12	2013	The information obtained from the crystal structure of human GMPS might therefore aid in understanding interactions of nucleoside-based drugs with GMPS and in structure-based design of GMPS-specific inhibitors.	Nucleosides	119-129	guanine monophosphate synthase	Homo sapiens	147-151
23816837-12	2013	The information obtained from the crystal structure of human GMPS might therefore aid in understanding interactions of nucleoside-based drugs with GMPS and in structure-based design of GMPS-specific inhibitors.	Nucleosides	119-129	guanine monophosphate synthase	Homo sapiens	147-151
23775562-3	2013	We hypothesized that multidrug resistance protein 4/ATP binding cassette transporter 4 (MRP4/ABCC4), a widely expressed transporter of nucleoside-based antiviral medications as well as cancer therapeutics might interact with PIs.	Nucleosides	135-145	ATP binding cassette subfamily C member 4	Homo sapiens	88-92
23688796-3	2013	These are amino acids and bioactive compounds that may be very important in i) preventing muscle wasting diseases, such as in sarcopenia, ii) reducing food and caloric intake to prevent metabolic syndrome, iii) blood pressure homeostasis via ACE-inhibitory components from connective tissue, and iv) maintaining functional gut environment through meat-derived nucleotides and nucleosides.	Nucleosides	376-387	angiotensin I converting enzyme	Homo sapiens	242-245
24066967-2	2013	Recent advances in our understanding of the structure and function of deoxycytidine kinase (dCK), a critical enzyme required for the anti-tumor activity for many nucleoside analogs, have clarified the mechanistic role this kinase plays in chemo- and radio-sensitization.	Nucleosides	162-172	deoxycytidine kinase	Homo sapiens	70-90
24066967-2	2013	Recent advances in our understanding of the structure and function of deoxycytidine kinase (dCK), a critical enzyme required for the anti-tumor activity for many nucleoside analogs, have clarified the mechanistic role this kinase plays in chemo- and radio-sensitization.	Nucleosides	162-172	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	92-95
24066967-4	2013	Since most currently employed nucleoside analogs are primarily activated by dCK, these findings lend fresh impetus to efforts focused on profiling and modulating dCK expression and activity in tumors.	Nucleosides	30-40	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	76-79
24066967-4	2013	Since most currently employed nucleoside analogs are primarily activated by dCK, these findings lend fresh impetus to efforts focused on profiling and modulating dCK expression and activity in tumors.	Nucleosides	30-40	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	162-165
24066967-5	2013	In this review we will briefly review the pharmacology and biochemistry of the major nucleoside analogs in clinical use that are activated by dCK.	Nucleosides	85-95	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	142-145
23819782-3	2013	CNT2 (concentrative nucleoside transporter 2) may play physiological roles beyond nucleoside salvage in brain as it does in other tissues.	Nucleosides	20-30	solute carrier family 28 member 2	Rattus norvegicus	0-4
24026568-3	2013	ENT1-4 mediate transport until intracellular/extracellular equilibrium of the transported compound, but are very efficient, when the accumulated nucleoside or nucleobase is rapidly eliminated by metabolism.	Nucleosides	145-155	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	0-4
24082115-5	2013	Moreover, MK2 activity was required for damage response, accumulation of ssDNA, and decreased survival when cells were treated with the nucleoside analogue gemcitabine or when the checkpoint kinase Chk1 was antagonized.	Nucleosides	136-146	MAP kinase-activated protein kinase 2	Mus musculus	10-13
24132197-2	2013	Our methodology demonstrates bromination at the C-5 position of pyrimidine nucleosides and the C-8 position of purine nucleosides.	Nucleosides	75-86	complement C5	Homo sapiens	48-51
23749968-2	2013	Here, we assessed the ability of nucleoside reverse-transcriptase inhibitor/nonnucleoside reverse-transcriptase inhibitor treatment to restore the CD4(+) T-cell populations in the intestine of South African patients with AIDS.	Nucleosides	33-43	CD4 molecule	Homo sapiens	147-150
23794217-5	2013	The strongest hypothetical biological mechanism was that rs3213764 alters the role of ATF7IP in the context of the pathways of negative regulation of transcription, negative regulation of nucleobase, nucleoside, nucleotide, and nucleic acid metabolic processes and negative regulation of gene expression (nominal p < 0.001, FDR = 0.043, 0.044, and 0.046, respectively).	Nucleosides	200-210	activating transcription factor 7 interacting protein	Homo sapiens	86-92
23934321-9	2013	In contrast, a high expression of SLC22A3 or SLC29A3 was significantly associated with longer overall survival in patients treated with nucleoside analogs.	Nucleosides	136-146	solute carrier family 22 member 3	Homo sapiens	34-41
23934321-9	2013	In contrast, a high expression of SLC22A3 or SLC29A3 was significantly associated with longer overall survival in patients treated with nucleoside analogs.	Nucleosides	136-146	solute carrier family 29 member 3	Homo sapiens	45-52
23775562-3	2013	We hypothesized that multidrug resistance protein 4/ATP binding cassette transporter 4 (MRP4/ABCC4), a widely expressed transporter of nucleoside-based antiviral medications as well as cancer therapeutics might interact with PIs.	Nucleosides	135-145	ATP binding cassette subfamily C member 4	Homo sapiens	93-98
23775562-12	2013	These findings suggest that HIV-infected cancer patients receiving nelfinavir might experience both enhanced antitumor efficacy and unexpected adverse toxicity given the role of MRP4/ABCC4 in exporting nucleoside-based antiretroviral medications and cancer chemotherapeutics.	Nucleosides	202-212	ATP binding cassette subfamily C member 4	Homo sapiens	178-182
23775562-12	2013	These findings suggest that HIV-infected cancer patients receiving nelfinavir might experience both enhanced antitumor efficacy and unexpected adverse toxicity given the role of MRP4/ABCC4 in exporting nucleoside-based antiretroviral medications and cancer chemotherapeutics.	Nucleosides	202-212	ATP binding cassette subfamily C member 4	Homo sapiens	183-188
23775789-0	2013	TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs.	Nucleosides	104-114	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	0-4
23897752-3	2013	The nucleoside exhibits high selectivity for c-myc G-quadruplex DNA through fluorescence enhancement over duplex DNA and other promoter G-quadruplexes (see scheme).	Nucleosides	4-14	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	45-50
23588157-3	2013	The cells of the digestive tract are literally plunged into a "biological sea" of functionally active nucleotides and nucleosides, which carry out the critical task of driving regulatory interventions on cellular functions through the activation of P1 and P2 receptors.	Nucleosides	118-129	crystallin gamma F, pseudogene	Homo sapiens	249-268
23949611-6	2013	The N (6)-threonylcarbamoyltransferase, YrdC, with nucleoside-specific recognition, was shown to bind the anticodon stem-loop of tRNA(Lys)UUU.	Nucleosides	51-61	yrdC N6-threonylcarbamoyltransferase domain containing	Homo sapiens	40-44
23184610-5	2013	Equilibrative nucleoside transporter 1 (ENT1) transfers hydrophilic nucleosides, such as adenosine, across the plasma membrane.	Nucleosides	68-79	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	0-38
23639800-0	2013	Basolateral uptake of nucleosides by Sertoli cells is mediated primarily by equilibrative nucleoside transporter 1.	Nucleosides	22-33	solute carrier family 29 member 1	Rattus norvegicus	76-114
23639800-10	2013	These data indicate that ENT1 is the primary route for basolateral nucleoside uptake into Sertoli cells and a possible mechanism for nucleosides and nucleoside-based drugs to undergo transepithelial transport.	Nucleosides	67-77	solute carrier family 29 member 1	Rattus norvegicus	25-29
23639800-10	2013	These data indicate that ENT1 is the primary route for basolateral nucleoside uptake into Sertoli cells and a possible mechanism for nucleosides and nucleoside-based drugs to undergo transepithelial transport.	Nucleosides	133-144	solute carrier family 29 member 1	Rattus norvegicus	25-29
23639800-10	2013	These data indicate that ENT1 is the primary route for basolateral nucleoside uptake into Sertoli cells and a possible mechanism for nucleosides and nucleoside-based drugs to undergo transepithelial transport.	Nucleosides	133-143	solute carrier family 29 member 1	Rattus norvegicus	25-29
23726973-3	2013	The functions of TIGAR were dispensable for normal growth and development in mice but played a key role in allowing intestinal regeneration in vivo and in ex vivo cultures, where growth defects due to lack of TIGAR were rescued by ROS scavengers and nucleosides.	Nucleosides	250-261	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	17-22
23621450-1	2013	Purine nucleoside phosphorylase is a transferase that catalyzes the addition of phosphate and removal of a purine base from guanosine and similar nucleosides.	Nucleosides	146-157	purine nucleoside phosphorylase	Homo sapiens	0-31
23560542-4	2013	The nucleoside model preferentially adpots a syn orientation (by 10-20 kJ mol(-1) depending on the OTA conformation) due to the presence of an O5"-H   N3 interaction.	Nucleosides	4-14	synemin	Homo sapiens	45-48
23560542-8	2013	These results indicate that the adduct will likely adopt a syn conformation in an isolated nucleoside and nucleotide, while a mixture of syn and anti conformations will be observed in DNA duplexes.	Nucleosides	91-101	synemin	Homo sapiens	59-62
23670538-4	2013	A protein not previously associated with nucleotide degradation, Phm8, converts nucleotide monophosphates into nucleosides.	Nucleosides	111-122	bifunctional nucleotidase/lysophosphatidic acid phosphatase	Saccharomyces cerevisiae S288C	65-69
23501114-5	2013	The incorporation of a d-ribofuranose into the hinged hybrids provided the corresponding nucleosides with the beta configuration, one of which inhibited HCV replication with an EC50 value of 20 muM.	Nucleosides	89-100	latexin	Homo sapiens	194-197
23789857-5	2013	Both nucleosides administered ip reduced mouse chronic neuropathic pain that was ascribed to either A3AR or A1/A3AR using A3AR genetic deletion.	Nucleosides	5-16	adenosine A3 receptor	Homo sapiens	100-104
23789857-5	2013	Both nucleosides administered ip reduced mouse chronic neuropathic pain that was ascribed to either A3AR or A1/A3AR using A3AR genetic deletion.	Nucleosides	5-16	adenosine A3 receptor	Mus musculus	111-115
23789857-5	2013	Both nucleosides administered ip reduced mouse chronic neuropathic pain that was ascribed to either A3AR or A1/A3AR using A3AR genetic deletion.	Nucleosides	5-16	adenosine A3 receptor	Mus musculus	111-115
23570983-7	2013	Moreover, we also showed that the RRM1-overexpressing tumor cells were also cross-resistant to cytarabine, another nucleoside analog commonly used in cancer therapy, and 4-(N)-stearoyl cytarabine carried by solid lipid nanoparticles can also overcome the resistance.	Nucleosides	115-125	ribonucleotide reductase catalytic subunit M1	Homo sapiens	34-38
23688195-4	2013	On the basis of this finding, we developed the ds-NIF (nucleoside with intrinsic fluorescence)-probe methodology for detection of cyclin D1 mRNA, by which the fluorescent probe is released upon recognition of target mRNA by the relatively dark NIF-duplex-probe.	Nucleosides	55-65	S100 calcium binding protein A9	Homo sapiens	50-53
23688195-4	2013	On the basis of this finding, we developed the ds-NIF (nucleoside with intrinsic fluorescence)-probe methodology for detection of cyclin D1 mRNA, by which the fluorescent probe is released upon recognition of target mRNA by the relatively dark NIF-duplex-probe.	Nucleosides	55-65	cyclin D1	Homo sapiens	130-139
23688195-4	2013	On the basis of this finding, we developed the ds-NIF (nucleoside with intrinsic fluorescence)-probe methodology for detection of cyclin D1 mRNA, by which the fluorescent probe is released upon recognition of target mRNA by the relatively dark NIF-duplex-probe.	Nucleosides	55-65	S100 calcium binding protein A9	Homo sapiens	244-247
26273017-4	2013	Here, we report the first case of WM/LPL who developed classical HL simultaneously 3 years after initial nucleoside analog-based chemotherapy.	Nucleosides	105-115	lipoprotein lipase	Homo sapiens	37-40
23184610-5	2013	Equilibrative nucleoside transporter 1 (ENT1) transfers hydrophilic nucleosides, such as adenosine, across the plasma membrane.	Nucleosides	68-79	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	40-44
23412628-5	2013	Inhibition of glycinamide ribonucleotide formyltransferase (GARFTase) was assayed by nucleoside protection assays and in situ GARFTase assays with [(14)C]glycine.	Nucleosides	85-95	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	14-58
23412628-5	2013	Inhibition of glycinamide ribonucleotide formyltransferase (GARFTase) was assayed by nucleoside protection assays and in situ GARFTase assays with [(14)C]glycine.	Nucleosides	85-95	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	Homo sapiens	60-68
23364618-1	2013	Fluorescent nucleosides (dU(bmz)) with desirable fluorescence quantum yield (Phi) are synthesized from almost non-fluorescent 5-fdU and o-phenylenediamine derivatives.	Nucleosides	12-23	glucose-6-phosphate isomerase	Homo sapiens	77-80
23109139-0	2013	Polymorphism of estrogen receptor alpha (ESR1) is associated with virological response to entecavir (ETV) in nucleoside-naive adult patients with chronic hepatitis B.	Nucleosides	109-119	estrogen receptor 1	Homo sapiens	16-39
23109139-0	2013	Polymorphism of estrogen receptor alpha (ESR1) is associated with virological response to entecavir (ETV) in nucleoside-naive adult patients with chronic hepatitis B.	Nucleosides	109-119	estrogen receptor 1	Homo sapiens	41-45
23109139-2	2013	MATERIALS AND METHODS: To test the hypothesis that polymorphisms in estrogen receptor alpha (ESR1) might influence the virological response to entecavir (ETV) therapy, we examined two polymorphisms (PvuII and XbaI) in 76 nucleoside-naive chronic hepatitis B (CHB) patients.	Nucleosides	221-231	estrogen receptor 1	Homo sapiens	68-91
23220537-1	2013	Clinical and preclinical observations have lead to the hypothesis that 5"-nucleotidase cN-II could constitute a therapeutic target in oncology, either per se or to increase the activity of cytotoxic nucleoside analogs.	Nucleosides	199-209	5'-nucleotidase ecto	Homo sapiens	71-86
23220537-1	2013	Clinical and preclinical observations have lead to the hypothesis that 5"-nucleotidase cN-II could constitute a therapeutic target in oncology, either per se or to increase the activity of cytotoxic nucleoside analogs.	Nucleosides	199-209	5'-nucleotidase, cytosolic II	Homo sapiens	87-92
23570720-3	2013	Most of these nucleoside analogs exhibited potent anti-HIV-1 activity with no cytotoxicity observed at the highest tested concentration up to 25 muM.	Nucleosides	14-24	latexin	Homo sapiens	145-148
23361057-4	2013	RESULTS: We identified cytarabine and other related cytosine-based nucleoside analogues as being selectively toxic to MLH1 and MSH2-deficient tumour cells.	Nucleosides	67-77	mutL homolog 1	Mus musculus	118-122
23290252-1	2013	Judicial structural modifications of 5:7-fused ring-expanded nucleosides (RENs), based on molecular modeling studies with one of its known targets, human RNA helicase (hDDX3), led to the lead, novel, 5:7-5-fused tricyclic heterocycle (1).	Nucleosides	61-72	DEAD-box helicase 3 X-linked	Homo sapiens	168-173
23593653-3	2013	Nucleoside analogs including azacytidine and decitabine have been used to inhibit DNMT and re-activate genes, and are clinically used.	Nucleosides	0-10	DNA methyltransferase 1	Homo sapiens	82-86
23246433-3	2013	As DKC1 functions in RNA processing, we tested whether SMUG1 excised modified bases in RNA and demonstrated that SMUG1 has activity on single-stranded RNA containing 5-hydroxymethyldeoxyuridine, but not pseudouridine, the nucleoside resulting from isomerization of uridine by DKC1.	Nucleosides	222-232	dyskerin pseudouridine synthase 1	Homo sapiens	3-7
23377281-3	2013	Using whole-exome sequencing, we identify mutations in the cytosolic 5"-nucleotidase II gene (NT5C2), which encodes a 5"-nucleotidase enzyme that is responsible for the inactivation of nucleoside-analog chemotherapy drugs, in 20/103 (19%) relapse T cell ALLs and 1/35 (3%) relapse B-precursor ALLs.	Nucleosides	185-195	5'-nucleotidase ecto	Homo sapiens	69-84
23377281-3	2013	Using whole-exome sequencing, we identify mutations in the cytosolic 5"-nucleotidase II gene (NT5C2), which encodes a 5"-nucleotidase enzyme that is responsible for the inactivation of nucleoside-analog chemotherapy drugs, in 20/103 (19%) relapse T cell ALLs and 1/35 (3%) relapse B-precursor ALLs.	Nucleosides	185-195	5'-nucleotidase, cytosolic II	Homo sapiens	94-99
23377281-3	2013	Using whole-exome sequencing, we identify mutations in the cytosolic 5"-nucleotidase II gene (NT5C2), which encodes a 5"-nucleotidase enzyme that is responsible for the inactivation of nucleoside-analog chemotherapy drugs, in 20/103 (19%) relapse T cell ALLs and 1/35 (3%) relapse B-precursor ALLs.	Nucleosides	185-195	5'-nucleotidase ecto	Homo sapiens	118-133
22902741-2	2013	Therefore, a one-step homogeneous assay for real-time determination of TK1 and dCK was developed by combining enzyme complementation with fluorescent signal generation using primer extension and a quenched probe oligodeoxyribonucleotide system at 37  C. Complementation, for producing dCTP and TTP from nucleoside substrates, was carried out by dTMP kinase and/or UMP/CMP kinase and nucleoside diphosphate kinase.	Nucleosides	303-313	thymidine kinase 1	Canis lupus familiaris	71-74
22902741-2	2013	Therefore, a one-step homogeneous assay for real-time determination of TK1 and dCK was developed by combining enzyme complementation with fluorescent signal generation using primer extension and a quenched probe oligodeoxyribonucleotide system at 37  C. Complementation, for producing dCTP and TTP from nucleoside substrates, was carried out by dTMP kinase and/or UMP/CMP kinase and nucleoside diphosphate kinase.	Nucleosides	303-313	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	79-82
23316210-7	2012	The aim of this review article is to provide an overview on the discovery and characterization of genetic polymorphisms in the human ABCC11 gene and to explain the impact of ABCC11 538G > A on the apocrine phenotype as well as the anthropological aspect of this SNP in the ABCC11 gene and patients" response to nucleoside-based chemotherapy.	Nucleosides	314-324	ATP binding cassette subfamily C member 11	Homo sapiens	133-139
23316210-7	2012	The aim of this review article is to provide an overview on the discovery and characterization of genetic polymorphisms in the human ABCC11 gene and to explain the impact of ABCC11 538G > A on the apocrine phenotype as well as the anthropological aspect of this SNP in the ABCC11 gene and patients" response to nucleoside-based chemotherapy.	Nucleosides	314-324	ATP binding cassette subfamily C member 11	Homo sapiens	174-180
23316210-7	2012	The aim of this review article is to provide an overview on the discovery and characterization of genetic polymorphisms in the human ABCC11 gene and to explain the impact of ABCC11 538G > A on the apocrine phenotype as well as the anthropological aspect of this SNP in the ABCC11 gene and patients" response to nucleoside-based chemotherapy.	Nucleosides	314-324	ATP binding cassette subfamily C member 11	Homo sapiens	174-180
23744559-2	2013	We aimed to investigate the expression of TLR3 in peripheral blood mononuclear cells (PBMCs) and liver cells of chronic hepatitis B (CHB) patients and its response to pegylated interferon or nucleoside analogue therapy.	Nucleosides	191-201	toll like receptor 3	Homo sapiens	42-46
23992316-5	2013	In districts, such as brain, which are dependent on salvage nucleotide synthesis, nucleosides are produced through the action of the ecto-5"-nucleotidase, the last component of a series of plasma-membrane bound enzyme proteins, catalyzing the successive dephosphorylation of released nucleoside-triphosphates.	Nucleosides	82-93	5'-nucleotidase ecto	Homo sapiens	133-153
23246433-3	2013	As DKC1 functions in RNA processing, we tested whether SMUG1 excised modified bases in RNA and demonstrated that SMUG1 has activity on single-stranded RNA containing 5-hydroxymethyldeoxyuridine, but not pseudouridine, the nucleoside resulting from isomerization of uridine by DKC1.	Nucleosides	222-232	single-strand-selective monofunctional uracil-DNA glycosylase 1	Homo sapiens	113-118
22859060-2	2013	Nucleoside triphosphate diphosphohydrolase-1; (CD39/ENTPD1) is an ectonucleotidase that regulates extracellular nucleotide/nucleoside concentrations by scavenging nucleotides to ultimately generate adenosine.	Nucleosides	123-133	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	47-51
23335963-1	2013	Overexpression of ribonucleotide reductase subunit M2 (RRM2), involved in deoxyribonucleotide synthesis, drives the chemoresistance of pancreatic cancer to nucleoside analogs (e.g., gemcitabine).	Nucleosides	156-166	ribonucleotide reductase regulatory subunit M2	Homo sapiens	18-53
23335963-1	2013	Overexpression of ribonucleotide reductase subunit M2 (RRM2), involved in deoxyribonucleotide synthesis, drives the chemoresistance of pancreatic cancer to nucleoside analogs (e.g., gemcitabine).	Nucleosides	156-166	ribonucleotide reductase regulatory subunit M2	Homo sapiens	55-59
23084905-1	2012	In our long and broad program to explore structure-activity relationships of the natural product azepinomycin and its analogues for inhibition of guanase, an important enzyme of purine salvage pathway of nucleic acid metabolism, it became necessary to investigate if the nucleoside analogues of the heterocycle azepinomycin, which are likely to be formed in vivo, would be more or less potent than the parent heterocycle.	Nucleosides	271-281	guanine deaminase	Homo sapiens	146-153
23992314-1	2013	The cytoplasmic 5"-nucleotidase cN-II is involved in the regulation of endogenous pools of nucleosides and nucleotides together with nucleoside kinases and other intracellular enzymes.	Nucleosides	91-102	5'-nucleotidase, cytosolic II	Homo sapiens	32-37
22888964-6	2013	Molecular dynamics simulations have been carried out to study the effect of modified nucleosides on the vRNA-tRNA(3)(Lys) complex stability and the destabilization effect of PNA oligomer on the vRNA-tRNA(3)(Lys)-PNA complex.	Nucleosides	85-96	vault RNA 1-1	Homo sapiens	104-108
24124690-4	2013	Higher phosphorylation levels were observed with thymidine kinase 1, the phosphorylation of nucleosides modified with metallacarboranes was observed for the first time.	Nucleosides	92-103	thymidine kinase 1	Homo sapiens	49-67
23441192-3	2013	We tested whether transfection of human concentrative nucleoside transporter 3 (hCNT3) using ultrasound and lipid stabilized microbubbles could increase gemcitabine uptake and sensitivity in HEK293 cells made nucleoside transport deficient by pharmacologic treatment with dilazep.	Nucleosides	54-64	solute carrier family 28 member 3	Homo sapiens	80-85
23393594-1	2013	Multidrug resistance protein 7 (MRP7, ABCC10) is a recently discovered member of the ATP-binding cassette (ABC) family which are capable of conferring resistance to a variety of anticancer drugs, including taxanes and nucleoside analogs, in vivo.	Nucleosides	218-228	ATP binding cassette subfamily C member 10	Homo sapiens	0-30
23393594-1	2013	Multidrug resistance protein 7 (MRP7, ABCC10) is a recently discovered member of the ATP-binding cassette (ABC) family which are capable of conferring resistance to a variety of anticancer drugs, including taxanes and nucleoside analogs, in vivo.	Nucleosides	218-228	ATP binding cassette subfamily C member 10	Homo sapiens	32-36
23393594-1	2013	Multidrug resistance protein 7 (MRP7, ABCC10) is a recently discovered member of the ATP-binding cassette (ABC) family which are capable of conferring resistance to a variety of anticancer drugs, including taxanes and nucleoside analogs, in vivo.	Nucleosides	218-228	ATP binding cassette subfamily C member 10	Homo sapiens	38-44
23230188-4	2012	The nucleoside salvage pathway is dependent on deoxycytidine kinase (dCK) and can be imaged in vivo by PET with 1-(2"-deoxy-2"-[18F]fluoroarabinofuranosyl) cytosine (FAC).	Nucleosides	4-14	deoxycytidine kinase	Homo sapiens	47-67
23230188-4	2012	The nucleoside salvage pathway is dependent on deoxycytidine kinase (dCK) and can be imaged in vivo by PET with 1-(2"-deoxy-2"-[18F]fluoroarabinofuranosyl) cytosine (FAC).	Nucleosides	4-14	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	69-72
22859060-2	2013	Nucleoside triphosphate diphosphohydrolase-1; (CD39/ENTPD1) is an ectonucleotidase that regulates extracellular nucleotide/nucleoside concentrations by scavenging nucleotides to ultimately generate adenosine.	Nucleosides	123-133	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	52-58
23148236-3	2012	In this study, we investigate a functional link between nucleotide deficiency, RS, and the nucleoside salvage pathway (NSP) enzymes deoxycytidine kinase (dCK) and thymidine kinase (TK1).	Nucleosides	91-101	deoxycytidine kinase	Mus musculus	132-152
23241934-8	2012	Moreover the nucleoside potentiated the early increase in the phosphorylation of the anti-apoptotic kinase Akt and the increase in the expression of the anti-apoptotic Bcl-2 protein induced by 6-OHDA.	Nucleosides	13-23	AKT serine/threonine kinase 1	Homo sapiens	107-110
23241934-8	2012	Moreover the nucleoside potentiated the early increase in the phosphorylation of the anti-apoptotic kinase Akt and the increase in the expression of the anti-apoptotic Bcl-2 protein induced by 6-OHDA.	Nucleosides	13-23	BCL2 apoptosis regulator	Homo sapiens	168-173
22707011-1	2012	Nucleotides and nucleosides are not only involved in cellular metabolism but also act extracellularly via P1 and P2 receptors, to elicit a wide variety of physiological and pathophysiological responses through paracrine and autocrine signalling pathways.	Nucleosides	16-27	crystallin gamma F, pseudogene	Homo sapiens	106-125
23058913-11	2012	Fibroblasts and B-LCL from the patient were not particularly protected when mitochondrial damage was induced using nucleoside-derived drugs susceptible to being transported by ENT3.	Nucleosides	115-125	solute carrier family 29 member 3	Homo sapiens	176-180
22924387-4	2012	Here, we demonstrate the reductive detoxification of toxic and mutagenic N-hydroxylated nucleobases and their corresponding nucleosides by the mammalian mARC-containing enzyme system.	Nucleosides	124-135	activity regulated cytoskeletal-associated protein	Mus musculus	153-157
23148236-3	2012	In this study, we investigate a functional link between nucleotide deficiency, RS, and the nucleoside salvage pathway (NSP) enzymes deoxycytidine kinase (dCK) and thymidine kinase (TK1).	Nucleosides	91-101	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	154-157
23148236-3	2012	In this study, we investigate a functional link between nucleotide deficiency, RS, and the nucleoside salvage pathway (NSP) enzymes deoxycytidine kinase (dCK) and thymidine kinase (TK1).	Nucleosides	91-101	thymidine kinase 1	Mus musculus	181-184
22985987-2	2012	ENT1 facilitates transport of FLT into cells and elevated levels of FLT are associated with both larger FLT-PET signals and increased response to nucleoside-based chemotherapies.	Nucleosides	146-156	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	0-4
23110675-0	2012	Amalgamation of nucleosides and amino acids in antibiotic biosynthesis: discovery of an L-threonine:uridine-5"-aldehyde transaldolase.	Nucleosides	16-27	transaldolase 1	Homo sapiens	120-133
23351306-2	2012	On the other hand according to literatures, ADA inhibitors without a nucleoside framework would improve pharmacokinetics and decrease toxicity.	Nucleosides	69-79	adenosine deaminase	Homo sapiens	44-47
23044854-0	2012	Ter-dependent stress response systems: novel pathways related to metal sensing, production of a nucleoside-like metabolite, and DNA-processing.	Nucleosides	96-106	trans-2,3-enoyl-CoA reductase	Homo sapiens	0-3
23044854-3	2012	Based on contextual information from conserved gene neighborhoods and domain architectures, we show that the ter gene products and TelA lie at the center of membrane-linked metal recognition complexes with regulatory ramifications encompassing phosphorylation-dependent signal transduction, RNA-dependent regulation, biosynthesis of nucleoside-like metabolites and DNA processing.	Nucleosides	333-343	trans-2,3-enoyl-CoA reductase	Homo sapiens	109-112
23044854-5	2012	Versions of the TerB domain might also bind small molecule ligands and link the TerD paralog-TerC complex to biosynthetic modules comprising phosphoribosyltransferases (PRTases), ATP grasp amidoligases, TIM-barrel carbon-carbon lyases, and HAD phosphoesterases, which are predicted to synthesize novel nucleoside-like molecules.	Nucleosides	302-312	telomerase RNA component	Homo sapiens	93-97
23041314-6	2012	The conserved nucleotide-binding hierarchy among TRiC subunits is evolutionarily modulated through differential nucleoside contacts.	Nucleosides	112-122	MARVEL domain containing 2	Homo sapiens	49-53
22887971-0	2012	Dipeptidyl peptidase IV-activated prodrugs of anti-varicella zoster virus bicyclic nucleoside analogues containing different self-cleavage spacer systems.	Nucleosides	83-93	dipeptidyl peptidase 4	Homo sapiens	0-23
22985415-5	2012	m(7)GTP and m(3)(2,2,7)GTP are cleaved at a slower rate than their corresponding dinucleotides (m(7)GpppG and m(3)(2,2,7)GpppG, respectively), indicating an involvement of the second nucleoside for efficient DcpS-mediated digestion.	Nucleosides	183-193	decapping enzyme, scavenger	Homo sapiens	208-212
22895883-2	2012	Isonucleoside is a type of nucleoside analogue, in which the nucleobase is moved from C-1 to other positions of ribose.	Nucleosides	3-13	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	86-89
22987068-0	2012	An efficient antigene activity and antiproliferative effect by targeting the Bcl-2 or survivin gene with triplex forming oligonucleotides containing a W-shaped nucleoside analogue (WNA-betaT).	Nucleosides	160-170	BCL2 apoptosis regulator	Homo sapiens	77-82
22850745-1	2012	Deoxycytidine kinase (dCK) is a rate limiting enzyme critical for phosphorylation of endogenous deoxynucleosides for DNA synthesis and exogenous nucleoside analogues for anticancer and antiviral drug actions.	Nucleosides	101-111	deoxycytidine kinase	Homo sapiens	0-20
22850745-1	2012	Deoxycytidine kinase (dCK) is a rate limiting enzyme critical for phosphorylation of endogenous deoxynucleosides for DNA synthesis and exogenous nucleoside analogues for anticancer and antiviral drug actions.	Nucleosides	101-111	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
23017148-0	2012	Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs.	Nucleosides	61-71	aquaporin 3 (Gill blood group)	Homo sapiens	0-11
23017148-0	2012	Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs.	Nucleosides	61-71	aquaporin 3 (Gill blood group)	Homo sapiens	13-17
23017148-1	2012	BACKGROUND: Nucleoside analogs used in the chemotherapy of solid tumors, such as the capecitabine catabolite 5"-deoxy-5-fluorouridine (5"-DFUR) trigger a transcriptomic response that involves the aquaglyceroporin aquaporin 3 along with other p53-dependent genes.	Nucleosides	12-22	aquaporin 3 (Gill blood group)	Homo sapiens	213-224
23017148-1	2012	BACKGROUND: Nucleoside analogs used in the chemotherapy of solid tumors, such as the capecitabine catabolite 5"-deoxy-5-fluorouridine (5"-DFUR) trigger a transcriptomic response that involves the aquaglyceroporin aquaporin 3 along with other p53-dependent genes.	Nucleosides	12-22	tumor protein p53	Homo sapiens	242-245
22709993-0	2012	Hypouricemic effects of novel concentrative nucleoside transporter 2 inhibitors through suppressing intestinal absorption of purine nucleosides.	Nucleosides	132-143	solute carrier family 28 member 2	Homo sapiens	30-68
22709993-4	2012	Based on the expression profile of human CNTs in digestive tract tissues, we established a working hypothesis that mainly CNT2 contributes to the intestinal absorption of purine nucleosides.	Nucleosides	178-189	solute carrier family 28 member 2	Homo sapiens	122-126
23341816-1	2012	Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a devastating autosomal recessive disorder due to mutations in TYMP, which cause loss of function of thymidine phosphorylase (TP), nucleoside accumulation in plasma and tissues and mitochondrial dysfunction.	Nucleosides	196-206	thymidine phosphorylase	Homo sapiens	128-132
22985564-7	2012	CONCLUSION: The immunomodulator IFN might be capable of increasing serum IL-21 levels, while nucleoside analogues can decrease IL-21 level in patients with chronic hepatitis B. HBeAg-negative patients have a significantly higher serum IL-21 level, suggesting that the expression of HBeAg might result in IL-21 depression.	Nucleosides	93-103	interleukin 21	Homo sapiens	127-132
22985564-7	2012	CONCLUSION: The immunomodulator IFN might be capable of increasing serum IL-21 levels, while nucleoside analogues can decrease IL-21 level in patients with chronic hepatitis B. HBeAg-negative patients have a significantly higher serum IL-21 level, suggesting that the expression of HBeAg might result in IL-21 depression.	Nucleosides	93-103	interleukin 21	Homo sapiens	127-132
22985564-7	2012	CONCLUSION: The immunomodulator IFN might be capable of increasing serum IL-21 levels, while nucleoside analogues can decrease IL-21 level in patients with chronic hepatitis B. HBeAg-negative patients have a significantly higher serum IL-21 level, suggesting that the expression of HBeAg might result in IL-21 depression.	Nucleosides	93-103	interleukin 21	Homo sapiens	127-132
22372734-0	2012	Nucleoside transport across the plasma membrane mediated by equilibrative nucleoside transporter 3 influences metabolism of Arabidopsis seedlings.	Nucleosides	0-10	Major facilitator superfamily protein	Arabidopsis thaliana	60-98
22490700-0	2012	Phosphorylation of deoxycytidine kinase on Ser-74: impact on kinetic properties and nucleoside analog activation in cancer cells.	Nucleosides	84-94	deoxycytidine kinase	Homo sapiens	19-39
22490700-1	2012	Deoxycytidine kinase (dCK) (EC 2.7.1.74) is a key enzyme in the activation of several therapeutic nucleoside analogs (NA).	Nucleosides	98-108	deoxycytidine kinase	Homo sapiens	0-20
22490700-1	2012	Deoxycytidine kinase (dCK) (EC 2.7.1.74) is a key enzyme in the activation of several therapeutic nucleoside analogs (NA).	Nucleosides	98-108	sticky	Drosophila melanogaster	22-25
22492015-4	2012	With a combination of studies with mammalian cells, Xenopus laevis oocytes, and RS1-null mice, evidence that RS1 down-regulates the localization and activity at the plasma membrane of the three members of this protein family (CNT1, CNT2, and CNT3) is provided, which indicates the biochemical basis for coordinate regulation of nucleoside uptake ability in epithelia and probably in other RS1-expressing cell types.	Nucleosides	328-338	retinoschisis (X-linked, juvenile) 1 (human)	Mus musculus	109-112
22492015-4	2012	With a combination of studies with mammalian cells, Xenopus laevis oocytes, and RS1-null mice, evidence that RS1 down-regulates the localization and activity at the plasma membrane of the three members of this protein family (CNT1, CNT2, and CNT3) is provided, which indicates the biochemical basis for coordinate regulation of nucleoside uptake ability in epithelia and probably in other RS1-expressing cell types.	Nucleosides	328-338	retinoschisis (X-linked, juvenile) 1 (human)	Mus musculus	109-112
23017148-5	2012	Moreover, AQP3 siRNA significantly blocked other effects of nucleoside analogs, including G1/S cell cycle arrest, p21 and FAS up-regulation, and cell growth inhibition.	Nucleosides	60-70	aquaporin 3 (Gill blood group)	Homo sapiens	10-14
23017148-5	2012	Moreover, AQP3 siRNA significantly blocked other effects of nucleoside analogs, including G1/S cell cycle arrest, p21 and FAS up-regulation, and cell growth inhibition.	Nucleosides	60-70	H3 histone pseudogene 16	Homo sapiens	114-117
22889300-1	2012	BACKGROUND: Thymidine analogue resistance mutations (TAMs) selected under treatment with nucleoside analogues generate two distinct genotypic profiles in the HIV-1 reverse transcriptase (RT): (i) TAM1: M41L, L210W and T215Y, and (ii) TAM2: D67N, K70R and K219E/Q, and sometimes T215F.	Nucleosides	89-99	stromal interaction molecule 1	Homo sapiens	196-200
22927829-4	2012	As a proof of concept we created a library of mutants of the human deoxycytidine kinase (dCK) gene, involved in the activation of nucleoside analogues used in cancer treatment, with the aim of isolating a variant sensitizing cancer cells to the chemotherapy compound Gemcitabine, to be used in gene therapy for anti-cancer approaches or as a poorly immunogenic negative selection marker for cell transplantation approaches.	Nucleosides	130-140	deoxycytidine kinase	Homo sapiens	67-87
22927829-4	2012	As a proof of concept we created a library of mutants of the human deoxycytidine kinase (dCK) gene, involved in the activation of nucleoside analogues used in cancer treatment, with the aim of isolating a variant sensitizing cancer cells to the chemotherapy compound Gemcitabine, to be used in gene therapy for anti-cancer approaches or as a poorly immunogenic negative selection marker for cell transplantation approaches.	Nucleosides	130-140	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	89-92
22728437-4	2012	We show that the nucleoside analogue triciribine inhibits ZNF217-induced tumor growth and chemotherapy resistance and inhibits signaling events [e.g., phospho-AKT, phospho-mitogen-activated protein kinase (MAPK)] in vivo.	Nucleosides	17-27	zinc finger protein 217	Homo sapiens	58-64
22728437-4	2012	We show that the nucleoside analogue triciribine inhibits ZNF217-induced tumor growth and chemotherapy resistance and inhibits signaling events [e.g., phospho-AKT, phospho-mitogen-activated protein kinase (MAPK)] in vivo.	Nucleosides	17-27	AKT serine/threonine kinase 1	Homo sapiens	159-162
22372734-2	2012	Uptake and fate of nucleosides imported by equilibrative nucleoside transporter 3 (ENT3) was analysed and, furthermore, a comprehensive analysis of the effect of exogenously fed nucleosides at the level of metabolic as well as transcriptomic alterations was performed.	Nucleosides	19-30	Major facilitator superfamily protein	Arabidopsis thaliana	43-81
22372734-2	2012	Uptake and fate of nucleosides imported by equilibrative nucleoside transporter 3 (ENT3) was analysed and, furthermore, a comprehensive analysis of the effect of exogenously fed nucleosides at the level of metabolic as well as transcriptomic alterations was performed.	Nucleosides	19-30	Major facilitator superfamily protein	Arabidopsis thaliana	83-87
22372734-3	2012	Expression of nucleoside transporters ENT1 and ENT3, together with nucleoside import, was increased upon nitrogen limitation.	Nucleosides	14-24	equilibrative nucleotide transporter 1	Arabidopsis thaliana	38-42
22372734-3	2012	Expression of nucleoside transporters ENT1 and ENT3, together with nucleoside import, was increased upon nitrogen limitation.	Nucleosides	14-24	Major facilitator superfamily protein	Arabidopsis thaliana	47-51
22372734-4	2012	Thereby a role for ENT3, which is expressed mainly in the vasculature of roots and leaves, as a major import route for nucleosides was supported.	Nucleosides	119-130	Major facilitator superfamily protein	Arabidopsis thaliana	19-23
22321533-2	2012	Positron emission tomography (PET) radiotracers based on a nucleoside core, such as 3"-[18F]fluoro-3"-deoxythymidine ([18F]FLT), have been extensively studied for this purpose.	Nucleosides	59-69	fms related receptor tyrosine kinase 1	Homo sapiens	123-126
22492015-1	2012	SLC28 genes encode three plasma membrane transporter proteins, human concentrative nucleoside transporter (CNT)1, CNT2, and CNT3, all of which are implicated in the uptake of natural nucleosides and a variety of nucleoside analogs used in the chemotherapy of cancer and viral and inflammatory diseases.	Nucleosides	183-194	solute carrier family 28 member 1	Homo sapiens	107-112
22492015-1	2012	SLC28 genes encode three plasma membrane transporter proteins, human concentrative nucleoside transporter (CNT)1, CNT2, and CNT3, all of which are implicated in the uptake of natural nucleosides and a variety of nucleoside analogs used in the chemotherapy of cancer and viral and inflammatory diseases.	Nucleosides	183-194	solute carrier family 28 member 2	Homo sapiens	114-118
22492015-1	2012	SLC28 genes encode three plasma membrane transporter proteins, human concentrative nucleoside transporter (CNT)1, CNT2, and CNT3, all of which are implicated in the uptake of natural nucleosides and a variety of nucleoside analogs used in the chemotherapy of cancer and viral and inflammatory diseases.	Nucleosides	183-194	solute carrier family 28 member 3	Homo sapiens	124-128
22492015-1	2012	SLC28 genes encode three plasma membrane transporter proteins, human concentrative nucleoside transporter (CNT)1, CNT2, and CNT3, all of which are implicated in the uptake of natural nucleosides and a variety of nucleoside analogs used in the chemotherapy of cancer and viral and inflammatory diseases.	Nucleosides	83-93	solute carrier family 28 member 1	Homo sapiens	107-112
22492015-1	2012	SLC28 genes encode three plasma membrane transporter proteins, human concentrative nucleoside transporter (CNT)1, CNT2, and CNT3, all of which are implicated in the uptake of natural nucleosides and a variety of nucleoside analogs used in the chemotherapy of cancer and viral and inflammatory diseases.	Nucleosides	83-93	solute carrier family 28 member 2	Homo sapiens	114-118
22492015-1	2012	SLC28 genes encode three plasma membrane transporter proteins, human concentrative nucleoside transporter (CNT)1, CNT2, and CNT3, all of which are implicated in the uptake of natural nucleosides and a variety of nucleoside analogs used in the chemotherapy of cancer and viral and inflammatory diseases.	Nucleosides	83-93	solute carrier family 28 member 3	Homo sapiens	124-128
22445509-2	2012	Using nucleoside pulse-chase experiments and clonal analysis, we determined that progenitor cells activate Math5 during or after the terminal division, with progressively later onset as histogenesis proceeds.	Nucleosides	6-16	atonal bHLH transcription factor 7	Mus musculus	107-112
22773864-0	2012	Bromination at C-5 of Pyrimidine and C-8 of Purine Nucleosides with 1,3-Dibromo-5,5-dimethylhydantoin.	Nucleosides	51-62	complement C5	Homo sapiens	15-18
22773864-0	2012	Bromination at C-5 of Pyrimidine and C-8 of Purine Nucleosides with 1,3-Dibromo-5,5-dimethylhydantoin.	Nucleosides	51-62	homeobox C8	Homo sapiens	37-40
22773864-1	2012	Treatment of the protected and unprotected nucleosides with 1,3-dibromo-5,5- dimethylhydantoin in aprotic solvents such as CH(2)Cl(2), CH(3)CN, or DMF effected smooth bromination of uridine and cytidine derivatives at C-5 of pyrimidine rings as well as adenosine and guanosine derivatives at C-8 of purine rings.	Nucleosides	43-54	complement C5	Homo sapiens	218-221
22773864-1	2012	Treatment of the protected and unprotected nucleosides with 1,3-dibromo-5,5- dimethylhydantoin in aprotic solvents such as CH(2)Cl(2), CH(3)CN, or DMF effected smooth bromination of uridine and cytidine derivatives at C-5 of pyrimidine rings as well as adenosine and guanosine derivatives at C-8 of purine rings.	Nucleosides	43-54	homeobox C8	Homo sapiens	292-295
22390204-8	2012	Cell-based experiments validate that the corresponding non-natural nucleoside produces robust cytostatic and cytotoxic effects against leukemia cells that overexpress TdT.	Nucleosides	67-77	DNA nucleotidylexotransferase	Homo sapiens	167-170
22644860-1	2012	The concentrative nucleoside transporter CNT1 and equilibrated nucleoside transporter ENT1 mediate the cellular uptake of naturally occurring pyrimidine and purine nucleosides and many structurally diverse anticancer and antiviral nucleoside analogs, thereby regulating drug responses or toxicity at the target site.	Nucleosides	164-175	solute carrier family 28 member 1	Homo sapiens	41-45
22644860-1	2012	The concentrative nucleoside transporter CNT1 and equilibrated nucleoside transporter ENT1 mediate the cellular uptake of naturally occurring pyrimidine and purine nucleosides and many structurally diverse anticancer and antiviral nucleoside analogs, thereby regulating drug responses or toxicity at the target site.	Nucleosides	164-175	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	86-90
22644860-1	2012	The concentrative nucleoside transporter CNT1 and equilibrated nucleoside transporter ENT1 mediate the cellular uptake of naturally occurring pyrimidine and purine nucleosides and many structurally diverse anticancer and antiviral nucleoside analogs, thereby regulating drug responses or toxicity at the target site.	Nucleosides	18-28	solute carrier family 28 member 1	Homo sapiens	41-45
22385435-1	2012	The first step for the intracellular retention of several anticancer or antiviral nucleoside analogues is the addition of a phosphate group catalysed by a deoxyribonucleoside kinase such as thymidine kinase 1 (TK1).	Nucleosides	82-92	thymidine kinase 1	Homo sapiens	190-208
22385435-1	2012	The first step for the intracellular retention of several anticancer or antiviral nucleoside analogues is the addition of a phosphate group catalysed by a deoxyribonucleoside kinase such as thymidine kinase 1 (TK1).	Nucleosides	82-92	thymidine kinase 1	Homo sapiens	210-213
22132702-4	2012	Using presteady state kinetic techniques, we have measured the substrate specificity values for human DNA polymerases beta, lambda, eta, iota, kappa, and Rev1 incorporating the active forms of the following anti-HBV nucleoside analogues approved for clinical use: adefovir, tenofovir, lamivudine, telbivudine, and entecavir.	Nucleosides	216-226	endothelin receptor type A	Homo sapiens	119-122
22023523-7	2012	Histone modifications and KAP1 phosphorylation are indicative of chromatin relaxation mediated by the nucleoside analogs, which sequentially increase Bu alkylation.	Nucleosides	102-112	tripartite motif containing 28	Homo sapiens	26-30
22285911-0	2012	ABC transporters and their role in nucleoside and nucleotide drug resistance.	Nucleosides	35-45	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	0-3
22285911-1	2012	ATP-binding cassette (ABC) transporters confer drug resistance against a wide range of chemotherapeutic agents, including nucleoside and nucleotide based drugs.	Nucleosides	122-132	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	0-20
22285911-1	2012	ATP-binding cassette (ABC) transporters confer drug resistance against a wide range of chemotherapeutic agents, including nucleoside and nucleotide based drugs.	Nucleosides	122-132	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	22-25
22285911-6	2012	This review will discuss ABC transporters and how they interact with other processes affecting the efficacy of nucleoside based drugs.	Nucleosides	111-121	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	25-28
22407915-3	2012	In this article, we describe a deficiency in deoxycytidine kinase (DCK), one of the major enzymes of the nucleoside salvage pathway, which affects peripheral T cell homeostatic proliferation and survival.	Nucleosides	105-115	deoxycytidine kinase	Mus musculus	45-65
22407915-3	2012	In this article, we describe a deficiency in deoxycytidine kinase (DCK), one of the major enzymes of the nucleoside salvage pathway, which affects peripheral T cell homeostatic proliferation and survival.	Nucleosides	105-115	deoxycytidine kinase	Mus musculus	67-70
22342844-5	2012	Both binding of oxidized mtDNA to the NLRP3 inflammasome and IL-1beta secretion could be competitively inhibited by the oxidized nucleoside 8-OH-dG.	Nucleosides	129-139	NLR family pyrin domain containing 3	Homo sapiens	38-43
22342844-5	2012	Both binding of oxidized mtDNA to the NLRP3 inflammasome and IL-1beta secretion could be competitively inhibited by the oxidized nucleoside 8-OH-dG.	Nucleosides	129-139	interleukin 1 beta	Homo sapiens	61-69
22349506-1	2012	Human equilibrative nucleoside transporter 1 (hENT1) is an important determinant for nucleoside analog based chemotherapy success.	Nucleosides	20-30	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
22422526-0	2012	N(3)-protection of thymidine with Boc for an easy synthetic access to sugar-alkylated nucleoside analogs.	Nucleosides	86-96	BOC cell adhesion associated, oncogene regulated	Homo sapiens	34-37
21455989-1	2012	DNA methyltransferase (DNMT)-inhibiting nucleoside analogs reactivate the expression of tumor suppressor genes and apoptosis-related genes silenced by methylation, thus favoring the induction of apoptosis in tumor cells.	Nucleosides	40-50	DNA methyltransferase 1	Homo sapiens	0-21
21455989-1	2012	DNA methyltransferase (DNMT)-inhibiting nucleoside analogs reactivate the expression of tumor suppressor genes and apoptosis-related genes silenced by methylation, thus favoring the induction of apoptosis in tumor cells.	Nucleosides	40-50	DNA methyltransferase 1	Homo sapiens	23-27
26286151-1	2012	Nucleosides that consist of base and sugar moieties can adopt two main conformations, syn and anti, about the glycosidic bond.	Nucleosides	0-11	synemin	Homo sapiens	86-89
22211580-2	2012	Herein, we describe a new type of photoconjugation reaction that has been shown to occur for 5-methylcytosine (5-MeC), 1,5-dimethylcytosine (1,5-diMeC), 1-methylthymine and thymidine; in this reaction the 5-methyl group of one nucleobase (or nucleoside) becomes attached to the 4-position of the second moiety.	Nucleosides	242-252	C-C motif chemokine ligand 28	Homo sapiens	113-116
22074567-5	2012	RESULTS: Six single nucleoside polymorphism (SNP) sites were identified in the sequencing of the promoter and exons of the 5-HT2A receptor gene; however, genotypes and allele frequencies of the SNPs did not show significant differences between the patients and controls except the -1438G/A polymorphism.	Nucleosides	20-30	5-hydroxytryptamine receptor 2A	Homo sapiens	123-138
22002103-4	2012	Additionally, nucleoside derivative-induced apoptosis was inhibited by the selective inhibitors of caspase-2, -3, -8, and -9 and also by si-RNAs against caspase-2, -3, -8, and -9; however, inhibition of caspase-2 and -3 was more effective at preventing apoptosis than inhibition of caspase-8 and -9.	Nucleosides	14-24	caspase 2	Homo sapiens	99-124
22002103-4	2012	Additionally, nucleoside derivative-induced apoptosis was inhibited by the selective inhibitors of caspase-2, -3, -8, and -9 and also by si-RNAs against caspase-2, -3, -8, and -9; however, inhibition of caspase-2 and -3 was more effective at preventing apoptosis than inhibition of caspase-8 and -9.	Nucleosides	14-24	caspase 2	Homo sapiens	153-178
22002103-4	2012	Additionally, nucleoside derivative-induced apoptosis was inhibited by the selective inhibitors of caspase-2, -3, -8, and -9 and also by si-RNAs against caspase-2, -3, -8, and -9; however, inhibition of caspase-2 and -3 was more effective at preventing apoptosis than inhibition of caspase-8 and -9.	Nucleosides	14-24	caspase 2	Homo sapiens	203-219
22002103-4	2012	Additionally, nucleoside derivative-induced apoptosis was inhibited by the selective inhibitors of caspase-2, -3, -8, and -9 and also by si-RNAs against caspase-2, -3, -8, and -9; however, inhibition of caspase-2 and -3 was more effective at preventing apoptosis than inhibition of caspase-8 and -9.	Nucleosides	14-24	caspase 8	Homo sapiens	282-298
22002103-7	2012	Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis.	Nucleosides	69-79	X-linked Kx blood group	Homo sapiens	33-36
22002103-7	2012	Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis.	Nucleosides	69-79	caspase 2	Homo sapiens	169-185
22002103-7	2012	Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis.	Nucleosides	69-79	caspase 2	Homo sapiens	169-178
22002103-9	2012	Our results also suggest that ROS are critical regulators of the sequential activation of caspase-2 and -3 in nucleoside derivative-treated cancer cells.	Nucleosides	110-120	caspase 2	Homo sapiens	90-106
21465168-0	2012	Deoxycytidine kinase is overexpressed in poor outcome breast cancer and determines responsiveness to nucleoside analogs.	Nucleosides	101-111	deoxycytidine kinase	Homo sapiens	0-20
21465168-2	2012	Responsiveness to the clinically important nucleoside analogs gemcitabine and decitabine may be critically determined by Deoxycytidine kinase (DCK) expression as this enzyme is required to convert the inactive prodrugs into their pharmacologically active forms.	Nucleosides	43-53	deoxycytidine kinase	Homo sapiens	121-141
21465168-2	2012	Responsiveness to the clinically important nucleoside analogs gemcitabine and decitabine may be critically determined by Deoxycytidine kinase (DCK) expression as this enzyme is required to convert the inactive prodrugs into their pharmacologically active forms.	Nucleosides	43-53	deoxycytidine kinase	Homo sapiens	143-146
21465168-7	2012	In support of this, we found a causal relationship between DCK levels and sensitivity to these nucleoside analogs in breast cancer cell lines.	Nucleosides	95-105	deoxycytidine kinase	Homo sapiens	59-62
21465168-8	2012	The data indicate that breast cancers that are at high risk of recurrence express higher levels of DCK, which we find to be strongly correlated to a favorable response to nucleoside analogs.	Nucleosides	171-181	deoxycytidine kinase	Homo sapiens	99-102
21465168-9	2012	The data suggest that DCK expression in breast cancer could be exploited to select patients that are likely to respond to treatment with nucleoside analogs.	Nucleosides	137-147	deoxycytidine kinase	Homo sapiens	22-25
22282239-13	2012	But etoposide, a nucleoside analogue, which could activate DNA-PKcs and ATM, increased Pim expression in ECs.	Nucleosides	17-27	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	59-67
22282239-13	2012	But etoposide, a nucleoside analogue, which could activate DNA-PKcs and ATM, increased Pim expression in ECs.	Nucleosides	17-27	ATM serine/threonine kinase	Homo sapiens	72-75
22282239-13	2012	But etoposide, a nucleoside analogue, which could activate DNA-PKcs and ATM, increased Pim expression in ECs.	Nucleosides	17-27	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	87-90
22806868-1	2012	Nucleoside analogues are used widely for the treatment of viral diseases and cancer, however the preparation of some important intermediates of these nucleoside analogues, including 2"-deoxyadenosine (dAR) and 5-methyluridine (5-MU), remains inconvenient.	Nucleosides	0-10	Allatostatin A receptor 2	Drosophila melanogaster	201-204
22806868-1	2012	Nucleoside analogues are used widely for the treatment of viral diseases and cancer, however the preparation of some important intermediates of these nucleoside analogues, including 2"-deoxyadenosine (dAR) and 5-methyluridine (5-MU), remains inconvenient.	Nucleosides	150-160	Allatostatin A receptor 2	Drosophila melanogaster	201-204
22806868-5	2012	These results indicate that our convenient and efficient method is ideal for the preparation of dAR and 5-MU, and has potential for the preparation of other nucleoside analogue intermediates.	Nucleosides	157-167	Allatostatin A receptor 2	Drosophila melanogaster	96-99
22132702-4	2012	Using presteady state kinetic techniques, we have measured the substrate specificity values for human DNA polymerases beta, lambda, eta, iota, kappa, and Rev1 incorporating the active forms of the following anti-HBV nucleoside analogues approved for clinical use: adefovir, tenofovir, lamivudine, telbivudine, and entecavir.	Nucleosides	216-226	REV1 DNA directed polymerase	Homo sapiens	154-158
22571666-4	2012	Some antiviral nucleoside analogs, such as 3"-azido-dThd (AZT) that is targeting the human immunodeficiency virus (HIV)-encoded reverse transcriptase, are substrates for TK2 and it has been proposed that the mitochondrial toxicity observed after prolonged treatment with such drugs could be due to their interaction with TK2.	Nucleosides	15-25	thymidine kinase 2	Homo sapiens	170-173
22041582-0	2012	Kinetic and in silico analysis of the slow-binding inhibition of human poly(A)-specific ribonuclease (PARN) by novel nucleoside analogues.	Nucleosides	117-127	poly(A)-specific ribonuclease	Homo sapiens	71-100
22041582-0	2012	Kinetic and in silico analysis of the slow-binding inhibition of human poly(A)-specific ribonuclease (PARN) by novel nucleoside analogues.	Nucleosides	117-127	poly(A)-specific ribonuclease	Homo sapiens	102-106
22571666-4	2012	Some antiviral nucleoside analogs, such as 3"-azido-dThd (AZT) that is targeting the human immunodeficiency virus (HIV)-encoded reverse transcriptase, are substrates for TK2 and it has been proposed that the mitochondrial toxicity observed after prolonged treatment with such drugs could be due to their interaction with TK2.	Nucleosides	15-25	thymidine kinase 2	Homo sapiens	321-324
22664241-5	2012	Among the four nucleosides, thymidine analogues, such as (18)F-FLT, have undergone years of development for clinical practice, while cytidine, adenosine and guanosine analogues receive less attention.	Nucleosides	15-26	fms related receptor tyrosine kinase 1	Homo sapiens	63-66
23302703-7	2012	The main function of NTPDase6 may be the regulation of nucleotide levels in cellular organelles by regulating the conversion of nucleotides to nucleosides.	Nucleosides	143-154	ectonucleoside triphosphate diphosphohydrolase 6	Homo sapiens	21-29
22204348-3	2012	Nucleic acid-like structures are well-known TLR7/8 ligands, such as single-stranded RNA (ssRNA), small interfering RNA (siRNA), CpG-oligodeoxynucleotides (ODNs) and nucleoside analogues.	Nucleosides	165-175	toll like receptor 7	Homo sapiens	44-48
22204348-6	2012	In this regard, chemical modification of nucleosides is very useful for production of specific pharmacological qualities of nucleic acid TLR7/8 ligands.	Nucleosides	41-52	toll like receptor 7	Homo sapiens	137-141
22354287-8	2012	These results suggest the involvement of placental ENT2 as well as ENT1 in nucleoside uptake from maternal blood, and the induction of CNT2 in experimental diabetes mellitus.	Nucleosides	75-85	solute carrier family 29 member 1	Rattus norvegicus	67-71
22040846-9	2012	Since NS3 and NS5 are required for DENV replication, this fascile assay could be used to screen for non-nucleoside, allosteric inhibitors that disrupt the interaction between the two proteins.	Nucleosides	104-114	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	14-17
22662200-7	2012	Several ligands were identified for UPP1: vidarabine, an antiviral nucleoside analog, as well as trifluridine, idoxuridine, floxuridine, zidovudine, telbivudine, fluorouracil and thioguanine caused concentration-dependent stabilization of UPP1.	Nucleosides	67-77	uridine phosphorylase 1	Homo sapiens	36-40
22848499-0	2012	Integrative gene expression profiling reveals G6PD-mediated resistance to RNA-directed nucleoside analogues in B-cell neoplasms.	Nucleosides	87-97	glucose-6-phosphate dehydrogenase	Homo sapiens	46-50
22662200-9	2012	The unexpected ligands identified for UPP1 and GDA imply further metabolic consequences for these nucleoside analogs, which could also serve as a starting point for future drug design.	Nucleosides	98-108	uridine phosphorylase 1	Homo sapiens	38-42
22662200-9	2012	The unexpected ligands identified for UPP1 and GDA imply further metabolic consequences for these nucleoside analogs, which could also serve as a starting point for future drug design.	Nucleosides	98-108	guanine deaminase	Homo sapiens	47-50
21840722-6	2011	The most potent compound, nucleoside 33, exhibited significant antiviral activity against pseudoviruses SF162 (IC(50)=7.0 muM) and HxB2 (IC(50)=2.4 muM).	Nucleosides	26-36	latexin	Homo sapiens	122-125
22272297-3	2012	Some nucleoside-analogues used in the treatment of HIV-seropositive (HIV+) patients are potential substrates for ITPase.	Nucleosides	5-15	inosine triphosphatase	Homo sapiens	113-119
22272297-9	2012	The effect of nucleoside analogues on ITPase activity was studied using lymphoblastic T-cell cultures and human recombinant ITPase.	Nucleosides	14-24	inosine triphosphatase	Homo sapiens	38-44
22174667-2	2011	Beside this physiological function, high level of cN-II expression is correlated with abnormal patient outcome when treated with cytotoxic nucleoside analogues.	Nucleosides	139-149	5'-nucleotidase, cytosolic II	Homo sapiens	50-55
21609761-9	2011	Our findings show that lithium treatment can alter ectonucleotidase and acetylcholinesterase activities, which may regulate extracellular nucleotide, nucleoside, and acetylcholine levels.	Nucleosides	150-160	acetylcholinesterase	Danio rerio	72-92
22039965-2	2011	We have examined pharmacologically the protective properties of a multivalent dendrimeric conjugate of a nucleoside as a selective multivalent agonist for the mouse A3AR.	Nucleosides	105-115	adenosine A3 receptor	Mus musculus	165-169
22039965-3	2011	RESULTS: A PAMAM dendrimer fully substituted by click chemistry on its peripheral groups with 64 moieties of a nucleoside agonist was shown to be potent and selective in binding to the mouse A3AR and effective in cardioprotection in an isolated mouse heart model of ischemia/reperfusion (I/R) injury.	Nucleosides	111-121	adenosine A3 receptor	Mus musculus	191-195
21872611-0	2011	Absence of equilibrative nucleoside transporter 1 in ENT1 knockout mice leads to altered nucleoside levels following hypoxic challenge.	Nucleosides	25-35	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	53-57
21910489-5	2011	Also, the alkylation mechanism of nucleosides by MXA has been studied in silico.	Nucleosides	34-45	MX dynamin like GTPase 1	Homo sapiens	49-52
21712425-12	2011	These results suggest that genetic variations in NT5C2 influence its expression and, potentially, cellular responses to nucleoside analogs.	Nucleosides	120-130	5'-nucleotidase, cytosolic II	Homo sapiens	49-54
21840722-6	2011	The most potent compound, nucleoside 33, exhibited significant antiviral activity against pseudoviruses SF162 (IC(50)=7.0 muM) and HxB2 (IC(50)=2.4 muM).	Nucleosides	26-36	latexin	Homo sapiens	148-151
21907764-2	2011	The hydrolysis of ATP by ectonucleotidases is an important source of adenosine, and adenosine deaminase (ADA) contributes to the regulation of this nucleoside concentration through its deamination.	Nucleosides	148-158	adenosine deaminase	Danio rerio	84-103
21907764-2	2011	The hydrolysis of ATP by ectonucleotidases is an important source of adenosine, and adenosine deaminase (ADA) contributes to the regulation of this nucleoside concentration through its deamination.	Nucleosides	148-158	adenosine deaminase	Danio rerio	105-108
21992803-6	2011	The model obtained in this study may provide guidance for future design of new potent and selective human A(3) AR full antagonists with a nucleoside skeleton.	Nucleosides	138-148	adenosine A3 receptor	Homo sapiens	106-113
21813458-0	2011	Nucleoside modifications in RNA limit activation of 2"-5"-oligoadenylate synthetase and increase resistance to cleavage by RNase L.	Nucleosides	0-10	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)	Mus musculus	123-130
21813458-6	2011	Nucleoside modifications also make RNA resistant to cleavage by RNase L.	Nucleosides	0-10	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)	Mus musculus	64-71
21813458-9	2011	The observation that modified nucleosides in RNA reduce 2-5A pathway activation joins OAS and RNase L to the list of RNA sensors and effectors whose functions are limited when RNA is modified, confirming the role of nucleoside modifications in suppressing immune recognition of RNA.	Nucleosides	30-41	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)	Mus musculus	94-101
21813458-9	2011	The observation that modified nucleosides in RNA reduce 2-5A pathway activation joins OAS and RNase L to the list of RNA sensors and effectors whose functions are limited when RNA is modified, confirming the role of nucleoside modifications in suppressing immune recognition of RNA.	Nucleosides	30-40	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)	Mus musculus	94-101
21873433-1	2011	The 5"-nucleotidase (NT5) family of enzyme dephosphorylates non-cyclic nucleoside monophosphates to produce nucleosides and inorganic phosphates.	Nucleosides	108-119	5'-nucleotidase ecto	Homo sapiens	4-19
21873433-1	2011	The 5"-nucleotidase (NT5) family of enzyme dephosphorylates non-cyclic nucleoside monophosphates to produce nucleosides and inorganic phosphates.	Nucleosides	108-119	5'-nucleotidase ecto	Homo sapiens	21-24
21574166-4	2011	The effects of DHEAS and related compounds on the uptake of [(3) H]AZT and other nucleosides by Molt-4 cells (a model of human CD4-positive T cells) were measured.	Nucleosides	81-92	sulfotransferase family 2A member 1	Homo sapiens	15-20
21730029-4	2011	The top gene ontology enriched by PTN were: muscle contraction, extracellular matrix--signaling and structure, and nucleoside, nucleotide, and nucleic acid metabolism (3 and 48 h); developmental processes, immunity, and defense (3 h); glycolysis, lipid and fatty acid metabolism (48 h).	Nucleosides	115-125	pleiotrophin	Homo sapiens	34-37
22629603-2	2011	PNP plays a leading role in the cell metabolism of nucleosides and nucleotides, as well as in maintaining the immune status of an organism.	Nucleosides	51-62	purine nucleoside phosphorylase	Homo sapiens	0-3
21110023-4	2011	RESULTS: Gene expression microarray analysis revealed that fetal hemoglobin genes and the multidrug resistance ABCB1 gene, encoding the drug efflux pump P-gp, were the most highly upregulated genes in the resistant cells, while genes traditionally associated with nucleoside analog resistance were not.	Nucleosides	264-274	ATP binding cassette subfamily B member 1	Homo sapiens	111-116
21110023-4	2011	RESULTS: Gene expression microarray analysis revealed that fetal hemoglobin genes and the multidrug resistance ABCB1 gene, encoding the drug efflux pump P-gp, were the most highly upregulated genes in the resistant cells, while genes traditionally associated with nucleoside analog resistance were not.	Nucleosides	264-274	phosphoglycolate phosphatase	Homo sapiens	153-157
21809900-2	2011	ENT1 is expressed ubiquitously in mammalian tissues and responsible for a significant portion of nucleoside analog drug uptake in humans.	Nucleosides	97-107	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	0-4
21472777-3	2011	Previously we showed that nucleosides promote osteoclastogenesis and bone-resorption activity in the presence of receptor activator for nuclear factor kappaB ligand (RANKL) in vitro.	Nucleosides	26-37	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	113-164
21912530-5	2011	We also found that the reported differences in telomeric gene silencing and DNA damage response of various elp3 alleles correlated with the levels of modified nucleosides at U34.	Nucleosides	159-170	elongator acetyltransferase complex subunit 3	Homo sapiens	107-111
21912530-5	2011	We also found that the reported differences in telomeric gene silencing and DNA damage response of various elp3 alleles correlated with the levels of modified nucleosides at U34.	Nucleosides	159-170	small nucleolar RNA, C/D box 34	Homo sapiens	174-177
21912530-7	2011	These observations show that Elongator complex does not directly participate in telomeric gene silencing and DNA damage response, but rather that modified nucleosides at U34 are important for efficient expression of gene products involved in these processes.	Nucleosides	155-166	small nucleolar RNA, C/D box 34	Homo sapiens	170-173
21598398-0	2011	Delineation of the molecular mechanisms of nucleoside recognition by cytidine deaminase through virtual screening.	Nucleosides	43-53	cytidine deaminase	Homo sapiens	69-87
21472777-3	2011	Previously we showed that nucleosides promote osteoclastogenesis and bone-resorption activity in the presence of receptor activator for nuclear factor kappaB ligand (RANKL) in vitro.	Nucleosides	26-37	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	166-171
21642237-8	2011	This indicates that ENT1-mediated nucleosides, especially adenosine transport, is important for nucleotide metabolism, thus influencing growth and pollen germination.	Nucleosides	34-45	equilibrative nucleotide transporter 1	Arabidopsis thaliana	20-24
21798026-0	2011	A nucleoside anticancer drug, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (TAS106), sensitizes cells to radiation by suppressing BRCA2 expression.	Nucleosides	2-12	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein	Cricetulus griseus	136-141
21402044-0	2011	Studies on the adenosine deaminase-catalyzed conversion of adenosine and nucleoside prodrugs by different capillary electrophoresis modes.	Nucleosides	73-83	adenosine deaminase	Homo sapiens	15-34
21679466-1	2011	BACKGROUND: Cladribine or 2-chlorodeoxyadenosine (2-CDA) is a well-known purine nucleoside analog with particular activity against lymphoproliferative disorders, such as hairy cell leukemia (HCL).	Nucleosides	80-90	cytidine deaminase	Homo sapiens	52-55
21444706-4	2011	One of the side effects of long-term treatment with nucleoside analogs is mitochondrial DNA depletion, which has been ascribed to competition by AZT for the endogenous dThd phosphorylation carried out by TK2.	Nucleosides	52-62	thymidine kinase 2	Homo sapiens	204-207
21674733-2	2011	METHODS: To evaluate the effects of nucleoside analog phosphorylation by Dm-dNK in vitro and in vivo, we generated a replication-deficient retroviral vector expressing Dm-dNK to transduce human breast cancer cells MCF7 (ER+) and MDA-MB-231 (ER-).	Nucleosides	36-46	deoxyribonucleoside kinase	Drosophila melanogaster	73-79
21674733-4	2011	RESULTS: The data obtained show that Dm-dNK is enzymatically active and its overexpression in the nuclei of breast cancer cells results in an increased sensitivity to the nucleoside analogs araC and araT in vitro.	Nucleosides	171-181	deoxyribonucleoside kinase	Drosophila melanogaster	37-43
21674733-6	2011	CONCLUSIONS: These results suggest that the Dm-dNK/nucleoside analog system could be a novel therapeutic strategy for treating breast cancer and improving anti-tumor efficacy, as well as for optimizing approaches for suicide gene therapy.	Nucleosides	51-61	deoxyribonucleoside kinase	Drosophila melanogaster	44-50
21576088-7	2011	These findings indicate that Abcc10 is dispensable for health and viability and that it is an endogenous resistance factor for taxanes, other natural product agents, and nucleoside analogues.	Nucleosides	170-180	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	Mus musculus	29-35
21235431-2	2011	Many studies have been performed replacing AZT or d4T with newer nucleoside analogs reverse transcriptase inhibitors (NRTIs) with less toxicity, such as tenofovir (TDF) or abacavir (ABC), maintaining virological efficacy.	Nucleosides	65-75	sex determining region Y	Homo sapiens	164-167
20945394-2	2011	ATP is metabolized into adenosine by human primary osteoblast cells (HPOC); due to very low activity of adenosine deaminase, the nucleoside is the end product of the ecto-nucleotidase cascade.	Nucleosides	129-139	adenosine deaminase	Homo sapiens	104-123
21658957-8	2011	Potent antiviral effects of D-2 and L-2 indicate that nucleosides belonging to a class of D4Ns can be an excellent candidate for anti-DNA virus agents.	Nucleosides	54-65	immunoglobulin kappa variable 3-15	Homo sapiens	36-39
22096991-4	2011	It was found that enzyme phosphorilate some modified nucleosides such as d2T, d4T, d2C, 3TC, FLT, BVDU, GCV.	Nucleosides	53-64	fms related receptor tyrosine kinase 1	Homo sapiens	93-96
21402067-3	2011	hENT1 is responsible for the uptake of nucleoside analog drugs used in treating viral infections and cancer, but despite its clinical importance, virtually nothing is known about the dynamics of the hENT1 life cycle including trafficking to the PM, endocytosis and degradation.	Nucleosides	39-49	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	0-5
21953107-0	2011	A nano-chip-LC/MSn based strategy for characterization of modified nucleosides using reduced porous graphitic carbon as a stationary phase.	Nucleosides	67-78	moesin	Homo sapiens	15-18
21953107-2	2011	Due to the hydrophilic and polar nature of nucleosides, down-scaling C18 analytical methods to a two-column nano-flow setup is inherently difficult.	Nucleosides	43-54	Bardet-Biedl syndrome 9	Homo sapiens	69-72
21953107-12	2011	The method was subsequently used for complete characterization of nucleosides found in tRNAs using both PGC and C18 chips.	Nucleosides	66-77	Bardet-Biedl syndrome 9	Homo sapiens	112-115
21394111-2	2011	E. coli PNP cleaves purine nucleoside analogs to generate toxic adenine analogs, which are activated by adenine phosphoribosyl transferase (APRT) to metabolites that inhibit RNA and protein synthesis.	Nucleosides	27-37	adenine phosphoribosyltransferase	Homo sapiens	140-144
21273003-1	2011	Nucleotide and nucleoside-degrading enzymes, such as nucleoside triphosphate diphosphohydrose (NTPDase), 5"-nucleotidase and adenosine deaminase (ADA) are present in the surface membranes of platelets, involved in clotting disturbances of Trypanosoma evansi-infected animals.	Nucleosides	15-25	adenosine deaminase	Rattus norvegicus	146-149
21545744-4	2011	We tested the effect of different reverse transcriptase inhibitors on L1 RT and found that all four tested nucleoside inhibitors efficiently inhibited L1 RT activity competitively.	Nucleosides	107-117	L1 cell adhesion molecule	Homo sapiens	70-72
21545744-4	2011	We tested the effect of different reverse transcriptase inhibitors on L1 RT and found that all four tested nucleoside inhibitors efficiently inhibited L1 RT activity competitively.	Nucleosides	107-117	L1 cell adhesion molecule	Homo sapiens	151-153
21382338-7	2011	No alterations of the deoxynucleotide pools were found, whereas a reduction in the expression of genes involved in nucleoside/nucleotide homeostasis (human equilibrative nucleoside transporter 1, thymidine phosphorylase) and mtDNA maintenance (DNA-polymerase gamma, mitochondrial transcription factor A) was observed.	Nucleosides	115-125	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	156-194
21351740-0	2011	Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.	Nucleosides	151-161	deoxycytidine kinase	Homo sapiens	57-77
21351740-1	2011	Deoxycytidine kinase (dCK) uses either ATP or UTP as a phosphoryl donor to catalyze the phosphorylation of nucleoside acceptors.	Nucleosides	107-117	deoxycytidine kinase	Homo sapiens	0-20
21351740-1	2011	Deoxycytidine kinase (dCK) uses either ATP or UTP as a phosphoryl donor to catalyze the phosphorylation of nucleoside acceptors.	Nucleosides	107-117	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
21351740-8	2011	The open dCK conformation is competent for the binding of nucleoside but not for phosphoryl transfer.	Nucleosides	58-68	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	9-12
21233276-3	2011	The availability of P1 and P2 ligands is modulated by ectonucleotidases, enzymes that hydrolyze extracellular nucleotides into nucleosides.	Nucleosides	127-138	crystallin gamma F, pseudogene	Homo sapiens	20-29
21444658-10	2011	This study also demonstrates that CLC-1 is a convenient experimental model for studying the interaction of nucleotides/nucleosides with the CBS domain.	Nucleosides	119-130	chloride voltage-gated channel 1	Homo sapiens	34-39
21127859-2	2011	dCK phosphorylates and therefore activates nucleoside analogs such as cytarabine, gemcitabine, decitabine, cladribine, and clofarabine that are used routinely in cancer therapy.	Nucleosides	43-53	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	0-3
21332170-0	2011	Dipeptidyl peptidase IV dependent water-soluble prodrugs of highly lipophilic bicyclic nucleoside analogues.	Nucleosides	87-97	dipeptidylpeptidase 4	Mus musculus	0-23
21319802-4	2011	Our efforts to widen the structural diversity of AK inhibitors led to the identification of novel non-nucleoside, noncompetitive allosteric modulators characterized by a unique molecular scaffold.	Nucleosides	102-112	adenosine kinase	Homo sapiens	49-51
21413197-9	2004	Phosphorylation of deoxyribonucleosides and their nucleoside analogs is carried out with deoxycytidine kinase (DCK) (5).	Nucleosides	28-38	deoxycytidine kinase	Homo sapiens	89-109
21413197-9	2004	Phosphorylation of deoxyribonucleosides and their nucleoside analogs is carried out with deoxycytidine kinase (DCK) (5).	Nucleosides	28-38	deoxycytidine kinase	Homo sapiens	111-114
21168391-0	2011	Nucleoside analogs induce proteasomal down-regulation of p21 in chronic lymphocytic leukemia cell lines.	Nucleosides	0-10	cyclin dependent kinase inhibitor 1A	Homo sapiens	57-60
21362344-1	2011	BACKGROUND: Single nucleotide polymorphisms (SNPs) in the deoxycytidine kinase (dCK) gene are associated with chemosensitivity to nucleoside analogs.	Nucleosides	130-140	deoxycytidine kinase	Homo sapiens	58-78
21235647-3	2011	NSH1 was found to be less efficient in the hydrolysis of further nucleosides.	Nucleosides	65-76	uridine-ribohydrolase 1	Arabidopsis thaliana	0-4
21235647-9	2011	NSH3, another NSH isoform, surprisingly functions as an extracellular, purine-specific hydrolase that is involved in degradation of extracellular nucleosides and may participate in wound and pathogen responses.	Nucleosides	146-157	inosine-uridine preferring nucleoside hydrolase family protein	Arabidopsis thaliana	0-4
21127790-2	2011	A series of thirteen 3"-amino-, 3"-guanidino- and 3"-tetrazole-containing nucleosides were synthesized and evaluated for their TK2 inhibitory activity.	Nucleosides	74-85	thymidine kinase 2	Homo sapiens	127-130
21362344-1	2011	BACKGROUND: Single nucleotide polymorphisms (SNPs) in the deoxycytidine kinase (dCK) gene are associated with chemosensitivity to nucleoside analogs.	Nucleosides	130-140	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	80-83
21284846-7	2011	Finally, with timed administration of nucleoside analogs we demonstrate that the Insm1 mutants contain fewer terminally dividing progenitors at embryonic day 12.5.	Nucleosides	38-48	insulinoma-associated 1	Mus musculus	81-86
21087930-7	2011	Added 5"-mononucleotides, nucleosides, and cysteine increased growth of the ttha0118 mutant in minimum essential medium.	Nucleosides	26-37	bifunctional oligoribonuclease/PAP phosphatase NrnA	Thermus thermophilus HB8	76-84
21190853-3	2011	siRNA bearing modified nucleoside was more active in silencing the gene expression of hepatocyte nuclear factor 4alpha (HNF4alpha) compared with siRNA bearing thymidine.	Nucleosides	23-33	hepatocyte nuclear factor 4 alpha	Homo sapiens	86-118
21145879-0	2011	Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase.	Nucleosides	49-59	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	34-38
21145879-0	2011	Regulation of ENT1 expression and ENT1-dependent nucleoside transport by c-Jun N-terminal kinase.	Nucleosides	49-59	jun proto-oncogene	Mus musculus	73-78
21145879-2	2011	Resistance to nucleoside-derived drugs strongly correlates with a deficiency of ENT1 expression in several tumor cells.	Nucleosides	14-24	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	80-84
21145879-8	2011	We propose that activation of JNK-cJun pathway negatively regulates mENT1 and suggest that this mechanism might contribute to the development of nucleoside analog-derived drug resistance.	Nucleosides	145-155	mitogen-activated protein kinase 8	Mus musculus	30-33
21145879-8	2011	We propose that activation of JNK-cJun pathway negatively regulates mENT1 and suggest that this mechanism might contribute to the development of nucleoside analog-derived drug resistance.	Nucleosides	145-155	jun proto-oncogene	Mus musculus	34-38
21145879-8	2011	We propose that activation of JNK-cJun pathway negatively regulates mENT1 and suggest that this mechanism might contribute to the development of nucleoside analog-derived drug resistance.	Nucleosides	145-155	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	68-73
21685538-2	2011	We investigated the changes in serum levels of the apoptotic caspase-generated fragments of keratin-18 (K-18) in hepatitis B e antigen (HBeAg)-negative CHB patients under nucleoside/nucleotide analogue(s).	Nucleosides	171-181	keratin 18	Homo sapiens	92-102
21685538-2	2011	We investigated the changes in serum levels of the apoptotic caspase-generated fragments of keratin-18 (K-18) in hepatitis B e antigen (HBeAg)-negative CHB patients under nucleoside/nucleotide analogue(s).	Nucleosides	171-181	keratin 18	Homo sapiens	104-108
21190853-3	2011	siRNA bearing modified nucleoside was more active in silencing the gene expression of hepatocyte nuclear factor 4alpha (HNF4alpha) compared with siRNA bearing thymidine.	Nucleosides	23-33	hepatocyte nuclear factor 4 alpha	Homo sapiens	120-129
21747939-5	2011	The 5-bp nucleoside sequence 5"-UGUGU-3" is a key determinant in inducing high levels of expression of IFN-alpha, -beta, -lambda and interleukin 1-beta in chicken cells.	Nucleosides	9-19	interleukin 1, beta	Gallus gallus	133-151
21900724-0	2011	Hepatitis B surface antigen (HBsAg) decrease and serum interferon-inducible protein-10 levels as predictive markers for HBsAg loss during treatment with nucleoside/nucleotide analogues.	Nucleosides	153-163	C-X-C motif chemokine ligand 10	Homo sapiens	55-86
21041096-0	2010	Comparative inhibitory activity of 3"- and 5"-functionalized nucleosides on ribonuclease A.	Nucleosides	61-72	ribonuclease A family member 1, pancreatic	Homo sapiens	76-90
20957432-3	2010	Field strength, pulse length, temperature, electroporation media, siRNA concentration, among other conditions were tested in order to obtain approximately 70-80% mRNA and enzyme activity downregulation of the cytosolic enzyme deoxycytidine kinase (dCK), necessary for nucleoside analog activation.	Nucleosides	268-278	deoxycytidine kinase	Homo sapiens	226-246
20957432-3	2010	Field strength, pulse length, temperature, electroporation media, siRNA concentration, among other conditions were tested in order to obtain approximately 70-80% mRNA and enzyme activity downregulation of the cytosolic enzyme deoxycytidine kinase (dCK), necessary for nucleoside analog activation.	Nucleosides	268-278	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	248-251
20957432-10	2010	The siRNA transfected cells with reduced dCK expression and activity showed reduced sensitivity to several nucleoside analogs as expected.	Nucleosides	107-117	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	41-44
21029378-2	2010	cN-II catalyses both the hydrolysis of nucleotides and transfer of their phosphate moiety to a nucleoside acceptor through formation of a covalent phospho-intermediate.	Nucleosides	95-105	5'-nucleotidase, cytosolic II	Homo sapiens	0-5
20979180-1	2010	Treatment with the nucleoside analog cytarabine has been shown to mimic changes in gene expression associated with downregulation of the EWS-FLI1 oncogene in Ewing sarcoma cell lines, selectively inhibit their growth in vitro, and cause tumor regression in athymic nude mice.	Nucleosides	19-29	Ewing sarcoma breakpoint region 1	Mus musculus	137-140
20979180-1	2010	Treatment with the nucleoside analog cytarabine has been shown to mimic changes in gene expression associated with downregulation of the EWS-FLI1 oncogene in Ewing sarcoma cell lines, selectively inhibit their growth in vitro, and cause tumor regression in athymic nude mice.	Nucleosides	19-29	Friend leukemia integration 1	Mus musculus	141-145
22132052-0	2010	Design of a novel nucleoside analog as potent inhibitor of the NAD dependent deacetylase, SIRT2.	Nucleosides	18-28	sirtuin 2	Homo sapiens	90-95
21152064-3	2010	In chemotherapeutic sensitivity screening assays, cells overexpressing pp32 were selectively resistant to the nucleoside analogs gemcitabine and cytarabine (ARA-C), but were sensitized to 5-fluorouracil; conversely, silencing pp32 in pancreatic cancer cells enhanced gemcitabine sensitivity.	Nucleosides	110-120	acidic nuclear phosphoprotein 32 family member A	Homo sapiens	71-75
22114715-1	2011	The nucleoside analogue Ribavirin significantly increases patient response to IFN-alpha treatment of HCV, by directly inhibiting viral replication.	Nucleosides	4-14	interferon alpha 1	Homo sapiens	78-87
20739293-2	2010	We report here that a human JmjC protein named Tyw5p (TYW5) unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxywybutosine, in tRNA(Phe) by catalyzing hydroxylation.	Nucleosides	117-127	tRNA-yW synthesizing protein 5	Homo sapiens	47-52
20739293-2	2010	We report here that a human JmjC protein named Tyw5p (TYW5) unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxywybutosine, in tRNA(Phe) by catalyzing hydroxylation.	Nucleosides	117-127	tRNA-yW synthesizing protein 5	Homo sapiens	54-58
21443122-1	2010	BACKGROUND/AIMS: Human Equilibrative Nucleoside Transporters 1 (hENT1) gene is involving in mediating nucleosides and nucleoside analog drugs across the plasma membrane, and may affect the chemotherapeutical efficacy.	Nucleosides	102-113	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	64-69
21443122-1	2010	BACKGROUND/AIMS: Human Equilibrative Nucleoside Transporters 1 (hENT1) gene is involving in mediating nucleosides and nucleoside analog drugs across the plasma membrane, and may affect the chemotherapeutical efficacy.	Nucleosides	102-112	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	64-69
20506327-1	2010	Concentrative nucleoside transporter 2 (CNT2) is a high-affinity adenosine transporter that may play physiological roles beyond nucleoside salvage.	Nucleosides	14-24	solute carrier family 28 member 2	Homo sapiens	40-44
20643903-1	2010	Human concentrative nucleoside transporter 3 (hCNT3) is a broad-selectivity, high-affinity protein implicated in the uptake of most nucleoside-derived anticancer and antiviral drugs.	Nucleosides	20-30	solute carrier family 28 member 3	Homo sapiens	46-51
20643903-2	2010	Regulated trafficking of hCNT3 has been recently postulated as a suitable way to improve nucleoside-based therapies.	Nucleosides	89-99	solute carrier family 28 member 3	Homo sapiens	25-30
20637175-1	2010	Deoxycytidine kinase (dCK) is a key enzyme in the salvage of deoxynucleosides and in the activation of several anticancer and antiviral nucleoside analogues.	Nucleosides	66-76	deoxycytidine kinase	Homo sapiens	0-20
20637175-1	2010	Deoxycytidine kinase (dCK) is a key enzyme in the salvage of deoxynucleosides and in the activation of several anticancer and antiviral nucleoside analogues.	Nucleosides	66-76	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
20592246-2	2010	Previous studies from our laboratory characterized PMAT as a polyspecific organic cation transporter that minimally interacts with nucleosides.	Nucleosides	131-142	solute carrier family 29 member 4	Homo sapiens	51-55
20592246-4	2010	To clarify the substrate specificity of PMAT, we comprehensively analyzed the transport activity of human PMAT toward nucleosides, nucleobases, and organic cations in heterologous expression systems under well controlled conditions.	Nucleosides	118-129	solute carrier family 29 member 4	Homo sapiens	106-110
20592246-5	2010	Among 12 naturally occurring nucleosides and nucleobases, only adenosine was significantly transported by PMAT.	Nucleosides	29-40	solute carrier family 29 member 4	Homo sapiens	106-110
19941076-2	2010	CDA also catalyzes the inactivation of some chemotherapeutic nucleoside analogues such as cytosine arabinoside and gemcitabine.	Nucleosides	61-71	cytidine deaminase	Homo sapiens	0-3
20978615-2	2010	A prototype compound was designed and docked into the catalytic domain of the AdSS enzyme bridging the region between the magnesium center of the protein to the nucleoside region.	Nucleosides	161-171	adenylosuccinate synthase 2	Homo sapiens	78-82
21747939-5	2011	The 5-bp nucleoside sequence 5"-UGUGU-3" is a key determinant in inducing high levels of expression of IFN-alpha, -beta, -lambda and interleukin 1-beta in chicken cells.	Nucleosides	9-19	interferon	Gallus gallus	103-112
20833052-0	2010	Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum.	Nucleosides	47-57	deoxythymidylate kinase	Homo sapiens	25-43
21182469-7	2010	Furthermore, the wild type of ABCC11 reportedly has ability to efflux cyclic nucleotides and nucleoside-based anticancer drugs.	Nucleosides	93-103	ATP binding cassette subfamily C member 11	Homo sapiens	30-36
20660103-5	2010	ENT1 and ENT2 expression was relatively high in nasal epithelia and olfactory bulb, which may explain the uptake of intranasally administered nucleoside derivatives observed by other investigators.	Nucleosides	142-152	solute carrier family 29 member 1	Rattus norvegicus	0-4
20595384-0	2010	Human equilibrative nucleoside transporter-3 (hENT3) spectrum disorder mutations impair nucleoside transport, protein localization, and stability.	Nucleosides	20-30	solute carrier family 29 member 3	Homo sapiens	46-51
20595384-6	2010	We report severe reductions/losses of hENT3 nucleoside transport functions of hENT3 syndrome mutants.	Nucleosides	44-54	solute carrier family 29 member 3	Homo sapiens	38-43
20595384-6	2010	We report severe reductions/losses of hENT3 nucleoside transport functions of hENT3 syndrome mutants.	Nucleosides	44-54	solute carrier family 29 member 3	Homo sapiens	78-83
20405259-1	2010	Multidrug resistance-associated protein 4 (MRP4) is an organic anion efflux pump capable of transporting nucleoside, nucleotide analogs, and cyclic nucleotide.	Nucleosides	105-115	ATP binding cassette subfamily C member 4	Homo sapiens	0-41
20405259-1	2010	Multidrug resistance-associated protein 4 (MRP4) is an organic anion efflux pump capable of transporting nucleoside, nucleotide analogs, and cyclic nucleotide.	Nucleosides	105-115	ATP binding cassette subfamily C member 4	Homo sapiens	43-47
20543083-6	2010	In the ENT1(-/-) cells, there is no change in ENT2 or ENBT1, resulting in a very low level of nucleoside uptake in these cells, but a high capacity for nucleobase accumulation.	Nucleosides	94-104	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	7-11
20553795-2	2010	Cladribine (2CdA) is a nucleoside analog that has been introduced as a promising agent for treatment of advanced SM.	Nucleosides	23-33	cytidine deaminase	Homo sapiens	13-16
20684612-0	2010	The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogues.	Nucleosides	22-32	deoxycytidine kinase	Homo sapiens	110-130
20684612-0	2010	The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogues.	Nucleosides	22-32	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	132-135
20684612-0	2010	The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analogues.	Nucleosides	22-32	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	174-177
20684612-4	2010	Therefore, we crystallized dCK in complex with ACV at the nucleoside phosphoryl acceptor site and UDP at the phosphoryl donor site.	Nucleosides	58-68	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	27-30
20684612-7	2010	In comparison to ACV binding to HSV1-TK, in dCK, the nucleoside base adopts a different orientation related by about a 60 degrees rotation.	Nucleosides	53-63	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	44-47
20614893-3	2010	This hypothesis is supported by the observation that mutations that enlarge the active site cavity in proximity to the nucleoside 5-position endow dCK with the ability to phosphorylate thymidine.	Nucleosides	119-129	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	147-150
20421346-1	2010	The human concentrative nucleoside transporter-3 C602R (hCNT3C602R), a recently identified human concentrative nucleoside transporter-3 (hCNT3) variant, has been shown to interact with natural nucleosides with apparent K(m) values similar to those of the wild-type transporter, although binding of one of the two sodium ions required for nucleoside translocation is impaired, resulting in decreased V(max) values (Mol Pharmacol 73:379-386, 2008).	Nucleosides	193-204	solute carrier family 28 member 3	Homo sapiens	56-61
20421346-2	2010	We have further analyzed the properties of this hCNT3 variant by determining its localization in plasma membrane lipid domains and its interaction with nucleoside-derived drugs used in anticancer and antiviral therapies.	Nucleosides	152-162	solute carrier family 28 member 3	Homo sapiens	48-53
20495821-1	2010	Human concentrative nucleoside transporter 3 (hCNT3) uses the electrochemical gradient of Na(+) and H(+) to drive the transport of nucleosides and therapeutic nucleoside analogs into the cells.	Nucleosides	131-142	solute carrier family 28 member 3	Homo sapiens	46-51
20495821-1	2010	Human concentrative nucleoside transporter 3 (hCNT3) uses the electrochemical gradient of Na(+) and H(+) to drive the transport of nucleosides and therapeutic nucleoside analogs into the cells.	Nucleosides	20-30	solute carrier family 28 member 3	Homo sapiens	46-51
20495821-7	2010	H(+)-coupled hCNT3 exhibited lower affinity for all natural nucleosides and different substrate selectivity compared to Na(+)-coupled hCNT3.	Nucleosides	60-71	solute carrier family 28 member 3	Homo sapiens	13-18
20525731-1	2010	Purine nucleoside phosphorylase (PNP) catalyzes the synthesis and phosphorolysis of purine nucleosides, interconverting nucleosides with their corresponding purine base and ribose-1-phosphate.	Nucleosides	91-102	purine nucleoside phosphorylase	Homo sapiens	0-31
20525731-1	2010	Purine nucleoside phosphorylase (PNP) catalyzes the synthesis and phosphorolysis of purine nucleosides, interconverting nucleosides with their corresponding purine base and ribose-1-phosphate.	Nucleosides	91-102	purine nucleoside phosphorylase	Homo sapiens	33-36
20525731-1	2010	Purine nucleoside phosphorylase (PNP) catalyzes the synthesis and phosphorolysis of purine nucleosides, interconverting nucleosides with their corresponding purine base and ribose-1-phosphate.	Nucleosides	120-131	purine nucleoside phosphorylase	Homo sapiens	0-31
20525731-1	2010	Purine nucleoside phosphorylase (PNP) catalyzes the synthesis and phosphorolysis of purine nucleosides, interconverting nucleosides with their corresponding purine base and ribose-1-phosphate.	Nucleosides	120-131	purine nucleoside phosphorylase	Homo sapiens	33-36
20525731-2	2010	While PNP plays significant roles in human and pathogen physiology, we are interested in developing PNP as a catalyst for the formation of nucleoside analog drugs of clinical relevance.	Nucleosides	139-149	purine nucleoside phosphorylase	Homo sapiens	100-103
21286341-0	2010	Long-term efficacy of nucleoside monotherapy in preventing HBV infection in HBsAg-negative recipients of anti-HBc-positive donor livers.	Nucleosides	22-32	keratin 88, pseudogene	Homo sapiens	110-113
21286341-13	2010	CONCLUSIONS: Nucleoside monotherapy is sufficient in preventing HBV infection in HBsAg-negative recipients of anti-HBc-positive donor livers.	Nucleosides	13-23	keratin 88, pseudogene	Homo sapiens	115-118
20591786-6	2010	It can be stated, that the antiviral therapy (interferon and nucleoside analogues) is able to decrease the risk of HCC or the recurrence of the tumor after curative treatment of HCC, in case of non responder state, as well.	Nucleosides	61-71	HCC	Homo sapiens	115-118
20720049-1	2010	UNLABELLED: The basis for the use of nucleoside tracers in PET is that activity of the cell-growth-dependent enzyme thymidine kinase 1 is the rate-limiting factor driving tracer retention in tumors.	Nucleosides	37-47	thymidine kinase 1	Homo sapiens	116-134
20346920-6	2010	It non-selectively activated the A(3)AR to inhibit forskolin-stimulated cAMP formation (IC(50) 66nM) and, similarly, protected A(3)-transfected HL-1 cells from apoptosis-inducing H(2)O(2) with greater potency (IC(50) 35nM) than monomeric nucleosides.	Nucleosides	238-249	adenosine A3 receptor	Mus musculus	33-39
20399479-2	2010	ADK phosphorylates cytokinin nucleosides, helping maintain a pool of bioactive cytokinins through interconversion of free-bases, nucleosides and nucleotides.	Nucleosides	29-40	adenosine kinase	Arabidopsis thaliana	0-3
20439460-7	2010	Using yeast as a surrogate system, we show that targeting PfNT2 to the plasma membrane of fui1Delta cells lacking the plasma membrane nucleoside transporter Fui1 confers sensitivity to the toxic nucleoside analog 5-fluorouridine.	Nucleosides	134-144	uridine permease	Saccharomyces cerevisiae S288C	157-161
20416341-0	2010	A novel nucleoside analog, 1-beta-d-ribofuranosyl-3-ethynyl-[1,2,4]triazole (ETAR), exhibits efficacy against a broad range of flaviviruses in vitro.	Nucleosides	8-18	endothelin receptor type A	Homo sapiens	77-81
20421393-1	2010	Concentrative nucleoside transporter 2 (CNT2) (encoded by the SLC28A2 gene) transports various antiviral or antitumor purine nucleoside analogs to be involved in their pharmacokinetics and pharmacological actions.	Nucleosides	14-24	solute carrier family 28 member 2	Rattus norvegicus	40-44
20421393-1	2010	Concentrative nucleoside transporter 2 (CNT2) (encoded by the SLC28A2 gene) transports various antiviral or antitumor purine nucleoside analogs to be involved in their pharmacokinetics and pharmacological actions.	Nucleosides	14-24	solute carrier family 28 member 2	Rattus norvegicus	62-69
20421393-3	2010	We concluded that CNT2 contributes considerably to nucleoside uptake in rat hepatocytes but not in mouse hepatocytes.	Nucleosides	51-61	solute carrier family 28 member 2	Rattus norvegicus	18-22
20682993-6	2010	RESULTS: Nucleoside analogs were significantly more cytotoxic to Dm-dNK-expressing cells than to their parental counterparts, and death was attributable to apoptosis.	Nucleosides	9-19	deoxyribonucleoside kinase	Drosophila melanogaster	65-71
20682993-7	2010	Implementation of the Dm-dNK/nucleoside analog system was associated with "bystander" effects in vitro and suppressed the growth of MGC-803 tumors in mice.	Nucleosides	29-39	deoxyribonucleoside kinase	Drosophila melanogaster	22-28
20682993-8	2010	CONCLUSION: The Dm-dNK/nucleoside analoguesystem possesses significant potential as suicide gene therapy for human gastric carcinoma.	Nucleosides	23-33	deoxyribonucleoside kinase	Drosophila melanogaster	16-22
20360301-0	2010	Vectorial transport of nucleoside analogs from the apical to the basolateral membrane in double-transfected cells expressing the human concentrative nucleoside transporter hCNT3 and the export pump ABCC4.	Nucleosides	23-33	solute carrier family 28 member 3	Homo sapiens	172-177
20360301-0	2010	Vectorial transport of nucleoside analogs from the apical to the basolateral membrane in double-transfected cells expressing the human concentrative nucleoside transporter hCNT3 and the export pump ABCC4.	Nucleosides	23-33	ATP binding cassette subfamily C member 4	Homo sapiens	198-203
20360301-3	2010	On the other hand, several human multidrug resistance proteins [human ATP-binding cassette transporter, subfamily C (ABCC)] cause resistance against nucleoside analogs and mediate transport of phosphorylated nucleoside derivatives out of the cells in an ATP-dependent manner.	Nucleosides	149-159	ATP binding cassette subfamily A member 4	Homo sapiens	70-102
20360301-3	2010	On the other hand, several human multidrug resistance proteins [human ATP-binding cassette transporter, subfamily C (ABCC)] cause resistance against nucleoside analogs and mediate transport of phosphorylated nucleoside derivatives out of the cells in an ATP-dependent manner.	Nucleosides	149-159	ATP binding cassette subfamily C member 1	Homo sapiens	117-121
20360301-3	2010	On the other hand, several human multidrug resistance proteins [human ATP-binding cassette transporter, subfamily C (ABCC)] cause resistance against nucleoside analogs and mediate transport of phosphorylated nucleoside derivatives out of the cells in an ATP-dependent manner.	Nucleosides	208-218	ATP binding cassette subfamily A member 4	Homo sapiens	70-102
20360301-3	2010	On the other hand, several human multidrug resistance proteins [human ATP-binding cassette transporter, subfamily C (ABCC)] cause resistance against nucleoside analogs and mediate transport of phosphorylated nucleoside derivatives out of the cells in an ATP-dependent manner.	Nucleosides	208-218	ATP binding cassette subfamily C member 1	Homo sapiens	117-121
20360301-6	2010	Recombinant hCNT3 mediated the transport of several known nucleoside substrates, and we identified 5-azacytidine as a new substrate for hCNT3.	Nucleosides	58-68	solute carrier family 28 member 3	Homo sapiens	12-17
20591786-6	2010	It can be stated, that the antiviral therapy (interferon and nucleoside analogues) is able to decrease the risk of HCC or the recurrence of the tumor after curative treatment of HCC, in case of non responder state, as well.	Nucleosides	61-71	HCC	Homo sapiens	178-181
20554721-1	2010	UNLABELLED: Deoxycytidine kinase (dCK) is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway and a critical determinant of therapeutic activity for several nucleoside analog prodrugs.	Nucleosides	81-91	deoxycytidine kinase	Mus musculus	12-32
20554721-1	2010	UNLABELLED: Deoxycytidine kinase (dCK) is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway and a critical determinant of therapeutic activity for several nucleoside analog prodrugs.	Nucleosides	81-91	sticky	Drosophila melanogaster	34-37
19932483-4	2010	This assay for the deoxyguanosine adduct of 4-ABP (dG-C8-4-ABP) gave mass detection limits of 20amol in 1.25microg of DNA (5 adducts in 10(9) nucleosides) with a linear range of 70amol to 70fmol.	Nucleosides	142-153	amine oxidase copper containing 1	Homo sapiens	46-49
19932483-4	2010	This assay for the deoxyguanosine adduct of 4-ABP (dG-C8-4-ABP) gave mass detection limits of 20amol in 1.25microg of DNA (5 adducts in 10(9) nucleosides) with a linear range of 70amol to 70fmol.	Nucleosides	142-153	amine oxidase copper containing 1	Homo sapiens	59-62
20219441-0	2010	An RNA-directed nucleoside anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) downregulation.	Nucleosides	16-26	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	132-179
20219441-0	2010	An RNA-directed nucleoside anti-metabolite, 1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR) downregulation.	Nucleosides	16-26	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	181-186
20219441-11	2010	We demonstrated for the first time that an RNA-directed nucleoside analog, ECyd, exerts its antitumor activity via downregulation of a novel regulator of apoptosis, TIGAR.	Nucleosides	56-66	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	165-170
20368736-9	2010	Additionally, the duration of Chk1-activated G2/M cell cycle arrest determines the level of autophagy following MMR processing of these nucleoside analogs.	Nucleosides	136-146	checkpoint kinase 1	Homo sapiens	30-34
20458493-10	2010	This study suggests close regulation of extracellular nucleoside and nucleotide levels in the genital tract by ecto-5"-nucleotidase that, in concurrence with NTPDases, may impact male fertility.	Nucleosides	54-64	5' nucleotidase, ecto	Mus musculus	111-131
20058055-9	2010	We suggest that up-regulation of Entpd3 mRNA expression modulates the extracellular concentration of nucleotides/nucleosides and affect P2-receptor signaling differently in quiescent-like cells and may play a role in the regulation of HSC functions.	Nucleosides	113-124	ectonucleoside triphosphate diphosphohydrolase 3	Mus musculus	33-39
20544523-2	2010	Nucleoside analogues, like AZT, are substrates of TK2 and induced mitochondrial toxicity in long-term therapy.	Nucleosides	0-10	thymidine kinase 2	Homo sapiens	50-53
20544526-1	2010	Deficiency in thymidine kinase 2 (TK2) activity due to genetic alterations caused tissue specific mitochondrial DNA (mtDNA) depletion syndrome with symptoms resembling these of AIDS patients treated with nucleoside analogues.	Nucleosides	204-214	thymidine kinase 2	Homo sapiens	14-32
20544526-1	2010	Deficiency in thymidine kinase 2 (TK2) activity due to genetic alterations caused tissue specific mitochondrial DNA (mtDNA) depletion syndrome with symptoms resembling these of AIDS patients treated with nucleoside analogues.	Nucleosides	204-214	thymidine kinase 2	Homo sapiens	34-37
20544527-1	2010	Deoxycytidine kinase (dCK) is a key enzyme in the salvage of deoxyribonucleosides and in the activation of several anticancer and antiviral nucleoside analogues.	Nucleosides	70-80	deoxycytidine kinase	Homo sapiens	0-20
20544527-1	2010	Deoxycytidine kinase (dCK) is a key enzyme in the salvage of deoxyribonucleosides and in the activation of several anticancer and antiviral nucleoside analogues.	Nucleosides	70-80	sticky	Drosophila melanogaster	22-25
20096265-2	2010	The nucleoside was able to increase both MMP-9 mRNA and protein levels through A3 receptors activation.	Nucleosides	4-14	matrix metallopeptidase 9	Homo sapiens	41-46
20515947-1	2010	Previously, we reported that the nucleoside analogue/transcriptional inhibitor ARC (4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)-pyrimidine-5-carboxamide) was able to induce p53-independent apoptosis in multiple cancer cell lines of different origins.	Nucleosides	33-43	tumor protein p53	Homo sapiens	190-193
20348107-0	2010	Interaction between DNA Polymerase lambda and anticancer nucleoside analogs.	Nucleosides	57-67	DNA polymerase lambda	Homo sapiens	20-41
20502711-6	2010	METHODOLOGY/PRINCIPAL FINDINGS: All nucleoside analogues analyzed, but not retinoic acid, triggered proteolytic degradation of the Polycomb group protein EZH2.	Nucleosides	36-46	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	154-158
20042597-8	2010	It was also suggested by studies of the inhibitory effect on rSNBT1-mediated uracil transport that several nucleobase analogs such as 5-fluorouracil are recognized by rSNBT1, but cytosine and nucleosides are not or only poorly recognized.	Nucleosides	192-203	similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2)	Rattus norvegicus	61-67
20362443-4	2010	The synthetic incorporation of this modified nucleoside into the catalytic core of a hammerhead ribozyme against the estrogen receptor alpha protein (ER-alpha), and transfection experiments in MCF-7 cell line are also presented.	Nucleosides	45-55	estrogen receptor 1	Homo sapiens	117-140
20362443-4	2010	The synthetic incorporation of this modified nucleoside into the catalytic core of a hammerhead ribozyme against the estrogen receptor alpha protein (ER-alpha), and transfection experiments in MCF-7 cell line are also presented.	Nucleosides	45-55	estrogen receptor 1	Homo sapiens	150-158
19784836-3	2010	However, exogenous purine nucleosides and bases may also enhance the cytotoxicity of even moderate concentrations of antifolate drugs (MTX and PTX) which inhibit dihydrofolate reductase.	Nucleosides	26-37	metaxin 1	Mus musculus	135-185
20222764-4	2010	The modeled structure of the enzyme was used for docking selective inhibitors (nucleotide analogs and the non-nucleoside inhibitor aphidicolin) in its active site in order to design new drugs for actinic keratosis and squamous cell carcinoma (SCC).	Nucleosides	110-120	serpin family B member 3	Homo sapiens	243-246
20201579-3	2010	Using nucleoside models and methods (B3LYP) similar to those previously implemented, we determine that the syn conformer is less stable than previously predicted when geometries relevant to B-DNA are considered.	Nucleosides	6-16	synemin	Homo sapiens	107-110
20205377-6	2010	On the basis of the salt dependence of the reaction and comparison with the corresponding nucleoside, the dianionic phosphate of 5"-GMP is one binding site for Ag(+), although this electrostatic interaction is not a dominant contribution to the overall heat change.	Nucleosides	90-100	5'-nucleotidase, cytosolic II	Homo sapiens	132-135
20164850-0	2010	Nucleoside analog ARC targets Mcl-1 to induce apoptosis in leukemia cells.	Nucleosides	0-10	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	30-35
20062055-4	2010	These atypical DNA nucleosides are converted by the uracil DNA glycosylase UNG2 to abasic lesions, which lead to foreign DNA degradation.	Nucleosides	19-30	uracil DNA glycosylase	Homo sapiens	75-79
20378362-8	2010	Two different binding modes of the nucleosides within the active sites of both enzymes were suggested with one predominating in the bacterial enzyme and the other in hTK1.	Nucleosides	35-46	thymidine kinase 1	Homo sapiens	166-170
20412327-1	2010	AIM: Nucleoside analog (NA)-interferon (IFN) sequential therapy may enable the long-term control of chronic hepatitis B (CHB) and the withdrawal of the nucleoside analog.	Nucleosides	5-15	interferon alpha 1	Homo sapiens	40-43
20412327-1	2010	AIM: Nucleoside analog (NA)-interferon (IFN) sequential therapy may enable the long-term control of chronic hepatitis B (CHB) and the withdrawal of the nucleoside analog.	Nucleosides	152-162	interferon alpha 1	Homo sapiens	40-43
20172853-1	2010	Human concentrative nucleoside transporter-3 (hCNT3) is a sodium-coupled nucleoside transporter that exhibits high affinity and broad substrate selectivity, making it the most suitable candidate for mediating the uptake and cytotoxic action of most nucleoside-derived drugs.	Nucleosides	20-30	solute carrier family 28 member 3	Homo sapiens	46-51
20196557-3	2010	An oxabicyclo[3.2.1]octane ring compound could alternatively be formed by RCM reaction between C-1-allyl and C-4-vinyl moieties and transformed to nucleoside analogues through a nucleophilic substitution reaction.	Nucleosides	147-157	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	95-98
20196557-3	2010	An oxabicyclo[3.2.1]octane ring compound could alternatively be formed by RCM reaction between C-1-allyl and C-4-vinyl moieties and transformed to nucleoside analogues through a nucleophilic substitution reaction.	Nucleosides	147-157	complement C4A (Rodgers blood group)	Homo sapiens	109-112
20060452-2	2010	Here, using a clone of mouse CNT1 (mCNT1), we investigated its transport characteristics and substrate specificity for synthetic nucleoside analogues, and compared them with those of human CNT1 (hCNT1).	Nucleosides	129-139	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	Mus musculus	29-33
20060452-2	2010	Here, using a clone of mouse CNT1 (mCNT1), we investigated its transport characteristics and substrate specificity for synthetic nucleoside analogues, and compared them with those of human CNT1 (hCNT1).	Nucleosides	129-139	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	Mus musculus	35-40
20060452-3	2010	In mCNT1-transfected Cos-7 cells, pyrimidine, but not purine, nucleosides showed sodium- and concentration-dependent uptake, and uridine uptake was competitively inhibited by uridine analogues, the rank order of the inhibitory effects being 5-bromouridine>3"-deoxyuridine>2"-deoxyuridine.	Nucleosides	62-73	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	Mus musculus	3-8
20060452-4	2010	cis- and trans-Inhibition studies involving synthetic nucleoside drugs revealed that gemcitabine and zidovudine greatly inhibited [(3)H]uridine uptake mediated by mCNT1 in the both cases, while cytarabine and zalcitabine showed small cis-inhibitory effect, and no trans-inhibitory effect on the uptake.	Nucleosides	54-64	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	Mus musculus	163-168
20080663-2	2010	dCK phosphorylates and therefore activates nucleoside analog prodrugs frequently used in cancer, autoimmunity, and viral infections.	Nucleosides	43-53	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	0-3
20080663-9	2010	The severe impact of dCK inactivation on lymphopoiesis was unexpected given that nucleoside salvage has been thought to play a limited, "fine-tuning" role in regulating deoxyribonucleotide triphosphate pools produced by the de novo pathway.	Nucleosides	81-91	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	21-24
20104904-0	2010	A novel non-natural nucleoside that influences P-glycoprotein activity and mediates drug resistance.	Nucleosides	20-30	ATP binding cassette subfamily B member 1	Homo sapiens	47-61
20104904-3	2010	This study evaluated the ability of various non-natural nucleosides that mimic the core structure of adenosine to modulate drug resistance by inhibiting the ATPase activity to P-gp.	Nucleosides	56-67	dynein axonemal heavy chain 8	Homo sapiens	157-163
20104904-3	2010	This study evaluated the ability of various non-natural nucleosides that mimic the core structure of adenosine to modulate drug resistance by inhibiting the ATPase activity to P-gp.	Nucleosides	56-67	ATP binding cassette subfamily B member 1	Homo sapiens	176-180
20104904-4	2010	Of several analogues tested, only one novel non-natural nucleoside, 5-cyclohexylindolyl-2"-deoxyribose (5-CHInd), behaves as a P-gp inhibitor.	Nucleosides	56-66	ATP binding cassette subfamily B member 1	Homo sapiens	127-131
20104904-5	2010	Although 5-CHInd is an adenosine analogue that should block the binding of ATP, the non-natural nucleoside surprisingly stimulates the ATPase activity of P-gp in vitro.	Nucleosides	96-106	dynein axonemal heavy chain 8	Homo sapiens	135-141
20104904-5	2010	Although 5-CHInd is an adenosine analogue that should block the binding of ATP, the non-natural nucleoside surprisingly stimulates the ATPase activity of P-gp in vitro.	Nucleosides	96-106	ATP binding cassette subfamily B member 1	Homo sapiens	154-158
20035027-4	2010	However, ENT1-null cardiomyocytes exhibit severely impaired nucleoside transport and lack ENT1 transcript and protein expression.	Nucleosides	60-70	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	9-13
20645920-2	2010	MRP1-5 can collectively confer resistance to natural product anticancer drugs and their conjugated metabolites, platinum compounds, folate antimetabolites, nucleoside and nucleotide analogs, and alkylating agents.	Nucleosides	156-166	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	0-4
19834107-3	2010	As hypoxia induces HIF-1alpha stabilization and adenosine (ado) accumulation, we investigated whether this nucleoside regulates HIF-1alpha in FCs.	Nucleosides	107-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-138
20606317-3	2010	Surprisingly, the introduction of the replicating plasmid DNA containing the Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK) gene was highly cytotoxic and caused cell death without nucleoside analogs.	Nucleosides	110-120	deoxyribonucleoside kinase	Drosophila melanogaster	129-135
19959816-1	2010	Deoxycytidine kinase (dCK) phosphorylates deoxycytidine, deoxyguanosine, and deoxyadenosine and plays an important role in the salvage pathway of nucleoside metabolism.	Nucleosides	146-156	deoxycytidine kinase	Homo sapiens	0-20
19959816-1	2010	Deoxycytidine kinase (dCK) phosphorylates deoxycytidine, deoxyguanosine, and deoxyadenosine and plays an important role in the salvage pathway of nucleoside metabolism.	Nucleosides	146-156	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
20391188-1	2010	Thymidine kinase 2 (TK2) is a mitochondrial deoxyribonucleoside kinase that phosphorylates several nucleoside analogs used in anti-viral and anti-cancer therapy.	Nucleosides	53-63	thymidine kinase 2	Homo sapiens	0-18
20391188-1	2010	Thymidine kinase 2 (TK2) is a mitochondrial deoxyribonucleoside kinase that phosphorylates several nucleoside analogs used in anti-viral and anti-cancer therapy.	Nucleosides	53-63	thymidine kinase 2	Homo sapiens	20-23
20391188-5	2010	This study suggests that nucleoside analog phosphorylation mediated by TK2 may be less important, compared to other deoxyribonucleoside kinases, for the cytotoxic effects of these compounds.	Nucleosides	25-35	thymidine kinase 2	Homo sapiens	71-74
19801629-4	2009	In PC12 cells, in which nucleoside transport strongly depended on ENT1, 8-pCPT-ado, 8-pCPT-2"-O-methyl-ado, and, to a smaller extent, 8-pCPT-2"-O-methyl-cAMP caused an increase of protein kinase A substrate motif phosphorylation and anti-apoptotic effect by an A(2A) adenosine receptor (A(2A)R)-dependent mechanism.	Nucleosides	24-34	solute carrier family 29 member 1	Rattus norvegicus	66-70
19801629-4	2009	In PC12 cells, in which nucleoside transport strongly depended on ENT1, 8-pCPT-ado, 8-pCPT-2"-O-methyl-ado, and, to a smaller extent, 8-pCPT-2"-O-methyl-cAMP caused an increase of protein kinase A substrate motif phosphorylation and anti-apoptotic effect by an A(2A) adenosine receptor (A(2A)R)-dependent mechanism.	Nucleosides	24-34	adenosine A2a receptor	Rattus norvegicus	261-285
19801629-4	2009	In PC12 cells, in which nucleoside transport strongly depended on ENT1, 8-pCPT-ado, 8-pCPT-2"-O-methyl-ado, and, to a smaller extent, 8-pCPT-2"-O-methyl-cAMP caused an increase of protein kinase A substrate motif phosphorylation and anti-apoptotic effect by an A(2A) adenosine receptor (A(2A)R)-dependent mechanism.	Nucleosides	24-34	adenosine A2a receptor	Rattus norvegicus	287-293
19801629-6	2009	In HEK 293 showing little endogenous ENT1-dependent nucleoside transport, transfection of ENT1 conferred A(2A)R-dependent increase in protein kinase A substrate motif phosphorylation.	Nucleosides	52-62	solute carrier family 29 member 1	Rattus norvegicus	90-94
19849830-5	2009	CO/CH4 and NH3/NH4+ in fluids distilled out of layer silicates and zeolites in the subducting plate at an early stage of subduction will react upon heating and form HCN, which is then available for further organic reactions to, for instance, carbohydrates, nucleosides or even nucleotides, under alkaline conditions in hydrated mantle rocks of the overriding plate.	Nucleosides	257-268	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	165-168
19457141-7	2009	For responders who discontinued therapy (per protocol), 24-week off-treatment evaluation is presented to provide a more "complete picture" of what clinicians can expect when treating nucleoside-naive HBeAg-positive patients with chronic hepatitis B.	Nucleosides	183-193	capsid protein;pre-capsid protein	Hepatitis B virus	200-205
19702335-4	2009	BDNF changed the abundance of proteins involved in (i) Nucleobase, nucleoside, nucleotide and nucleic acid metabolism, (ii) protein metabolism, (iii) carbohydrate metabolism, (iv) regulators of apoptosis, and (v) regulators of cell proliferation.	Nucleosides	67-77	brain derived neurotrophic factor	Homo sapiens	0-4
19699178-1	2009	Human Equilibrative Nucleoside Transporter 1 (hENT1) is an integral membrane protein that transports nucleosides and analog drugs across cellular membranes.	Nucleosides	101-112	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	6-44
19699178-1	2009	Human Equilibrative Nucleoside Transporter 1 (hENT1) is an integral membrane protein that transports nucleosides and analog drugs across cellular membranes.	Nucleosides	101-112	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
19620215-0	2009	Conformationally rigid nucleoside probes help understand the role of sugar pucker and nucleobase orientation in the thrombin-binding aptamer.	Nucleosides	23-33	coagulation factor II, thrombin	Homo sapiens	116-124
19546363-0	2009	Potent activity of a nucleoside reverse transcriptase inhibitor, 4"-ethynyl-2-fluoro-2"-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice.	Nucleosides	21-31	atrophin 1	Homo sapiens	228-231
19546363-0	2009	Potent activity of a nucleoside reverse transcriptase inhibitor, 4"-ethynyl-2-fluoro-2"-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice.	Nucleosides	21-31	Janus kinase 3	Homo sapiens	237-251
19555658-1	2009	Thymidine phosphorylase (TP) first identified as platelet derived endothelial cell growth factor (PD-ECGF) plays a key role in nucleoside metabolism.	Nucleosides	127-137	thymidine phosphorylase	Homo sapiens	49-96
19555658-1	2009	Thymidine phosphorylase (TP) first identified as platelet derived endothelial cell growth factor (PD-ECGF) plays a key role in nucleoside metabolism.	Nucleosides	127-137	thymidine phosphorylase	Homo sapiens	98-105
19726854-6	2009	An intramolecular O-H...N hydrogen bond stabilizes the syn conformation of the nucleoside.	Nucleosides	79-89	synemin	Homo sapiens	55-58
19620215-4	2009	The substitution at positions 5, 10 and 14 with a locked South/syn-dG nucleoside produced aptamers with the same stability and global structure as the innate, unmodified one.	Nucleosides	70-80	synemin	Homo sapiens	63-66
19620215-5	2009	Replacing position 15 with the same South/syn-dG nucleoside induced a strong destabilization of the aptamer, while the antipodal North/anti-dG nucleoside was less destabilizing.	Nucleosides	49-59	synemin	Homo sapiens	42-45
19596579-1	2009	We describe (i) a simple method for the synthesis of C5-modified nucleosides from 5-iodo-2"-deoxyuridine and (ii) their activity against six types of human cancer cell lines (HCT15, MM231, NCI-H23, NUGC-3, PC-3, ACHN).	Nucleosides	65-76	La ribonucleoprotein 6, translational regulator	Homo sapiens	212-216
19631328-4	2009	For the separation of a mixture of nucleosides and thymine, guanine and adenine with purine uncleobases, which exhibit greater aromaticity than pyrimidine nucleobases, performed a higher retention in the MEP capillary through a pi-pi interaction than in the MES capillary.	Nucleosides	35-46	neurolysin	Homo sapiens	204-207
19422047-3	2009	The nucleoside analog triciribine (TCN), which was initially described as a DNA synthesis inhibitor, has recently been shown to function as an inhibitor of Akt.	Nucleosides	4-14	AKT serine/threonine kinase 1	Homo sapiens	156-159
19523820-4	2009	The 1-naphthyl phosphoramidate of beta-2"-methylguanosine containing the benzyl ester (20) was the most active at 0.12microM, an 84-fold of increase in activity compared to the parent nucleoside (2) with no increase of cytotoxicity.	Nucleosides	184-194	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	34-40
19494110-1	2009	Human concentrative nucleoside transporter, hCNT3, mediates Na+/nucleoside and H+/nucleoside co-transport.	Nucleosides	20-30	solute carrier family 28 member 3	Homo sapiens	44-49
19494110-10	2009	In acid environments, including renal proximal tubule, H+/nucleoside co-transport may drive nucleoside accumulation by hCNT3.	Nucleosides	58-68	solute carrier family 28 member 3	Homo sapiens	119-124
19494110-11	2009	Fusion of mNect to hCNT3 provided a simple, self-referencing, and effective way to monitor nucleoside transport, suggesting an approach that may have applications in assays of transport activity of other H(+)-coupled transport proteins.	Nucleosides	91-101	solute carrier family 28 member 3	Homo sapiens	19-24
19520578-0	2009	Synthesis of novel purine nucleosides towards a selective inhibition of human butyrylcholinesterase.	Nucleosides	26-37	butyrylcholinesterase	Homo sapiens	78-99
19520578-3	2009	The nucleosides as well as their sugar precursors were screened for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition.	Nucleosides	4-15	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-88
19520578-3	2009	The nucleosides as well as their sugar precursors were screened for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition.	Nucleosides	4-15	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-94
19520578-3	2009	The nucleosides as well as their sugar precursors were screened for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition.	Nucleosides	4-15	butyrylcholinesterase	Homo sapiens	100-121
19520578-3	2009	The nucleosides as well as their sugar precursors were screened for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition.	Nucleosides	4-15	butyrylcholinesterase	Homo sapiens	123-127
19472977-7	2009	To understand how the nucleosides fit into the active site of PARN, we performed molecular docking experiments followed by molecular dynamics simulations.	Nucleosides	22-33	poly(A)-specific ribonuclease	Homo sapiens	62-66
19336477-3	2009	Five loss-of-function mutations were identified in the SLC29A3 gene which encodes a member of a highly conserved protein family that transports nucleosides, nucleobases and nucleoside analogue drugs, hENT3.	Nucleosides	144-155	solute carrier family 29 member 3	Homo sapiens	55-62
19472977-3	2009	In the present study, we show that synthetic nucleoside analogues bearing a fluoro-glucopyranosyl sugar moiety and benzoyl-modified cytosine or adenine as a base can effectively inhibit human PARN.	Nucleosides	45-55	poly(A)-specific ribonuclease	Homo sapiens	192-196
19380585-2	2009	Na(+)-coupled hCNT1 and hCNT2 transport pyrimidine and purine nucleosides, respectively, whereas hCNT3 mediates transport of both pyrimidine and purine nucleosides utilizing Na(+) and/or H(+) electrochemical gradients.	Nucleosides	62-73	solute carrier family 28 member 1	Homo sapiens	14-19
19380585-2	2009	Na(+)-coupled hCNT1 and hCNT2 transport pyrimidine and purine nucleosides, respectively, whereas hCNT3 mediates transport of both pyrimidine and purine nucleosides utilizing Na(+) and/or H(+) electrochemical gradients.	Nucleosides	62-73	solute carrier family 28 member 2	Homo sapiens	24-29
19336477-3	2009	Five loss-of-function mutations were identified in the SLC29A3 gene which encodes a member of a highly conserved protein family that transports nucleosides, nucleobases and nucleoside analogue drugs, hENT3.	Nucleosides	144-155	solute carrier family 29 member 3	Homo sapiens	200-205
19336477-3	2009	Five loss-of-function mutations were identified in the SLC29A3 gene which encodes a member of a highly conserved protein family that transports nucleosides, nucleobases and nucleoside analogue drugs, hENT3.	Nucleosides	144-154	solute carrier family 29 member 3	Homo sapiens	55-62
19336477-3	2009	Five loss-of-function mutations were identified in the SLC29A3 gene which encodes a member of a highly conserved protein family that transports nucleosides, nucleobases and nucleoside analogue drugs, hENT3.	Nucleosides	144-154	solute carrier family 29 member 3	Homo sapiens	200-205
19287302-0	2009	Excision of nucleoside analogs in mitochondria by p53 protein.	Nucleosides	12-22	tumor protein p53	Homo sapiens	50-53
19297449-7	2009	Collectively, this evidence suggested that apical hCNT3 and basolateral hENT2 are involved in proximal tubular reabsorption of adenosine and some nucleoside drugs and that apical hENT1 and basolateral hOATs are involved in proximal tubular secretion of 2"-deoxyadenosine.	Nucleosides	146-156	solute carrier family 28 member 3	Homo sapiens	50-55
19297449-7	2009	Collectively, this evidence suggested that apical hCNT3 and basolateral hENT2 are involved in proximal tubular reabsorption of adenosine and some nucleoside drugs and that apical hENT1 and basolateral hOATs are involved in proximal tubular secretion of 2"-deoxyadenosine.	Nucleosides	146-156	solute carrier family 29 member 2	Homo sapiens	72-77
19480391-1	2009	The nucleoside analogue 5-aza-2"-deoxycytidine (Decitabine, DAC) is one of several drugs in clinical use that inhibit DNA methyltransferases, leading to a decrease of 5-methylcytosine in newly replicated DNA and subsequent transcriptional activation of genes silenced by cytosine methylation.	Nucleosides	4-14	arylacetamide deacetylase	Homo sapiens	60-63
19375920-3	2009	All synthesized nucleosides exhibited potent and selective binding affinity at the human A(3) AR.	Nucleosides	16-27	adenosine A3 receptor	Homo sapiens	89-96
19244331-10	2009	Interestingly, some RBV-resistant cell lines may compensate for reduced ENT1-mediated nucleoside uptake by increasing the activity of an alternative nucleoside transporter, ENT2.	Nucleosides	86-96	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	72-76
19244331-10	2009	Interestingly, some RBV-resistant cell lines may compensate for reduced ENT1-mediated nucleoside uptake by increasing the activity of an alternative nucleoside transporter, ENT2.	Nucleosides	86-96	solute carrier family 29 member 2	Homo sapiens	173-177
20183596-2	2009	It has been shown that a reaction of benzoquinone with aminopropenyl group at C-5-position of 2"-deoxyuridine or 2"-deoxycytidine and aminopropynyl group at the C-7-position of 8-aza-7-deazaadenosine under extremely mild conditions affords conjugated benzoxazole derivatives of nucleosides, which possess strong fluorescent properties.	Nucleosides	278-289	complement C5	Homo sapiens	78-81
20183596-2	2009	It has been shown that a reaction of benzoquinone with aminopropenyl group at C-5-position of 2"-deoxyuridine or 2"-deoxycytidine and aminopropynyl group at the C-7-position of 8-aza-7-deazaadenosine under extremely mild conditions affords conjugated benzoxazole derivatives of nucleosides, which possess strong fluorescent properties.	Nucleosides	278-289	complement C7	Homo sapiens	161-164
19287302-7	2009	RESULTS: The results demonstrate that the excision of incorporated nucleoside analogs in mitochondrial fractions of H1299 cells increased in the presence of purified recombinant p53, or cytoplasmic extracts of large cell carcinoma 2 cells expressing endogenous wild-type p53 (but not specifically predepleted extracts) or cytoplasmic extracts of H1299 cells overexpressing wild-type p53, but not exonuclease-deficient mutant p53-R175H.	Nucleosides	67-77	tumor protein p53	Homo sapiens	271-274
19287302-8	2009	The amount of nucleoside analogs incorporated into the elongated DNA with mitochondrial fractions of human colon carcinoma 116 (HCT116)(p53+/+) cells was lower than that of HCT116(p53-/-) cells.	Nucleosides	14-24	tumor protein p53	Homo sapiens	136-139
19287302-8	2009	The amount of nucleoside analogs incorporated into the elongated DNA with mitochondrial fractions of human colon carcinoma 116 (HCT116)(p53+/+) cells was lower than that of HCT116(p53-/-) cells.	Nucleosides	14-24	tumor protein p53	Homo sapiens	180-183
19287302-9	2009	Furthermore, mitochondrion-localized elevation of p53 in HCT116(p53+/+) cells, following the irradiation-stress stimuli, correlates with the reduction in incorporation of nucleoside analogs and wrong nucleotides.	Nucleosides	171-181	tumor protein p53	Homo sapiens	50-53
19379728-8	2009	Using the nucleoside-transporter-deficient PK15NTD cells that stably express equilibrative nucleoside transport (ENT) 1 and ENT2, it was found that the inhibitory effect of sulindac sulfide on ENT1 was greater than that on ENT2.	Nucleosides	10-20	equilibrative nucleoside transporter 1	Sus scrofa	193-197
19342873-0	2009	The cyclin-dependent kinase inhibitor roscovitine and the nucleoside analog sangivamycin induce apoptosis in caspase-3 deficient breast cancer cells independent of caspase mediated P-glycoprotein cleavage: implications for therapy of drug resistant breast cancers.	Nucleosides	58-68	caspase 3	Homo sapiens	109-118
19233899-7	2009	In addition, a striking close correlation was found between the inhibitory activities of the test compounds against TK-2 and Mycobacterium tuberculosis thymidylate kinase that is strongly indicative of close structural and/or functional similarities between both enzymes in relation to their mode of interaction with these nucleoside analog inhibitors.	Nucleosides	323-333	thymidine kinase 2	Homo sapiens	116-120
20560637-1	2009	We describe the use of nonpolar nucleoside analogues of systematically varied size and shape to probe the mechanisms by which the two human thymidine kinases (TK1 and TK2) recognize and phosphorylate their substrate, thymidine.	Nucleosides	32-42	thymidine kinase 1	Homo sapiens	159-162
20560637-1	2009	We describe the use of nonpolar nucleoside analogues of systematically varied size and shape to probe the mechanisms by which the two human thymidine kinases (TK1 and TK2) recognize and phosphorylate their substrate, thymidine.	Nucleosides	32-42	thymidine kinase 2	Homo sapiens	167-170
19287302-9	2009	Furthermore, mitochondrion-localized elevation of p53 in HCT116(p53+/+) cells, following the irradiation-stress stimuli, correlates with the reduction in incorporation of nucleoside analogs and wrong nucleotides.	Nucleosides	171-181	tumor protein p53	Homo sapiens	64-67
19287302-10	2009	CONCLUSION: p53 in mitochondria may functionally interact with DNA polymerase gamma, thus providing a proofreading function during mitochondrial DNA replication for excision of nucleoside analogs and polymerization errors.	Nucleosides	177-187	tumor protein p53	Homo sapiens	12-15
19287302-4	2009	In the present study, we investigated the ability of p53 to excise incorporated nucleoside analogs from DNA in mitochondria.	Nucleosides	80-90	tumor protein p53	Homo sapiens	53-56
19287302-5	2009	DESIGN: The functional interaction of p53 and DNA polymerase gamma during the incorporation of nucleoside analog was examined in mitochondrial fractions of p53-null H1299 cells, as the source of DNA polymerase gamma.	Nucleosides	95-105	tumor protein p53	Homo sapiens	38-41
19287302-7	2009	RESULTS: The results demonstrate that the excision of incorporated nucleoside analogs in mitochondrial fractions of H1299 cells increased in the presence of purified recombinant p53, or cytoplasmic extracts of large cell carcinoma 2 cells expressing endogenous wild-type p53 (but not specifically predepleted extracts) or cytoplasmic extracts of H1299 cells overexpressing wild-type p53, but not exonuclease-deficient mutant p53-R175H.	Nucleosides	67-77	tumor protein p53	Homo sapiens	178-181
19287302-7	2009	RESULTS: The results demonstrate that the excision of incorporated nucleoside analogs in mitochondrial fractions of H1299 cells increased in the presence of purified recombinant p53, or cytoplasmic extracts of large cell carcinoma 2 cells expressing endogenous wild-type p53 (but not specifically predepleted extracts) or cytoplasmic extracts of H1299 cells overexpressing wild-type p53, but not exonuclease-deficient mutant p53-R175H.	Nucleosides	67-77	tumor protein p53	Homo sapiens	271-274
19287302-7	2009	RESULTS: The results demonstrate that the excision of incorporated nucleoside analogs in mitochondrial fractions of H1299 cells increased in the presence of purified recombinant p53, or cytoplasmic extracts of large cell carcinoma 2 cells expressing endogenous wild-type p53 (but not specifically predepleted extracts) or cytoplasmic extracts of H1299 cells overexpressing wild-type p53, but not exonuclease-deficient mutant p53-R175H.	Nucleosides	67-77	tumor protein p53	Homo sapiens	271-274
19164483-7	2009	Transport studies in hENT3 gene-silenced JAR cells showed significant reduction in mitochondrial transport of nucleosides and nucleoside drugs.	Nucleosides	110-120	solute carrier family 29 member 3	Homo sapiens	21-26
19164483-9	2009	hENT3-mediated mitochondrial transport may play an important role in mediating clinically observed mitochondrial toxicity of nucleoside drugs.	Nucleosides	125-135	solute carrier family 29 member 3	Homo sapiens	0-5
19164483-6	2009	Xenopus oocytes expressing NH2-terminal-deleted hENT3 (expressed at the cell surface) showed pH-dependent interaction with several classes of nucleosides (anti-HIV ddNs, gemcitabine, fialuridine, ribavirin) that produce mitochondrial toxicity.	Nucleosides	142-153	solute carrier family 29 member 3	Homo sapiens	48-53
19164483-7	2009	Transport studies in hENT3 gene-silenced JAR cells showed significant reduction in mitochondrial transport of nucleosides and nucleoside drugs.	Nucleosides	110-121	solute carrier family 29 member 3	Homo sapiens	21-26
19275147-4	2009	Our studies revealed that a limited set of intrinsic solute properties can be used to predict the RRF of various classes of metabolites (e.g., amino acids, amines, peptides, acylcarnitines, nucleosides, etc.)	Nucleosides	190-201	mitochondrial ribosome recycling factor	Homo sapiens	98-101
19228884-2	2009	CNT1 mediates the uptake of naturally occurring pyrimidine nucleosides, but also nucleoside analogs used in anticancer and antiviral therapy.	Nucleosides	59-69	solute carrier family 28 member 1	Homo sapiens	0-4
19136562-0	2009	Dissecting APOBEC3G substrate specificity by nucleoside analog interference.	Nucleosides	45-55	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	11-19
19372559-2	2009	High-mobility group protein 1 (HMGB1) is a DNA damage sensor responsive to the incorporation of nonnatural nucleosides into DNA; several nuclear and cytosolic proteins are functionally integrated with HMGB1 in the context of DNA damage response.	Nucleosides	107-118	high mobility group box 1	Homo sapiens	31-36
19372559-2	2009	High-mobility group protein 1 (HMGB1) is a DNA damage sensor responsive to the incorporation of nonnatural nucleosides into DNA; several nuclear and cytosolic proteins are functionally integrated with HMGB1 in the context of DNA damage response.	Nucleosides	107-118	high mobility group box 1	Homo sapiens	201-206
19136562-4	2009	In the present study we have used nucleoside analog interference mapping to probe A3G-DNA interactions throughout the enzyme-substrate complex as well as to determine which DNA structural features determine substrate specificity.	Nucleosides	34-44	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	82-85
19136562-5	2009	Our results indicate that multiple components of nucleosides within the consensus sequence are important for substrate recognition by A3G (with base moieties being most critical), whereas deamination interference by analog substitution outside this region is minimal.	Nucleosides	49-60	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	134-137
19738938-9	2009	Concluding, our study demonstrates that glucose and insulin differentially affect the activities of adenosine metabolizing enzymes in human B lymphocytes, but changes in those activities do not correlate with the adenosine level in cell media during accelerated ATP catabolism, implying that nucleoside transport is the primary factor determining the extracellular level of adenosine.	Nucleosides	292-302	insulin	Homo sapiens	52-59
19771229-2	2009	Previous studies have shown that RNAi-mediated knockdown of either the RRM1 or RRM2 subunit sensitizes cells to the cytotoxic effects of the nucleoside analogs and more recently it has been shown that RRM2 knockdown itself has a growth inhibitory effect.	Nucleosides	141-151	ribonucleotide reductase catalytic subunit M1	Homo sapiens	71-75
19771229-2	2009	Previous studies have shown that RNAi-mediated knockdown of either the RRM1 or RRM2 subunit sensitizes cells to the cytotoxic effects of the nucleoside analogs and more recently it has been shown that RRM2 knockdown itself has a growth inhibitory effect.	Nucleosides	141-151	ribonucleotide reductase regulatory subunit M2	Homo sapiens	79-83
19771229-2	2009	Previous studies have shown that RNAi-mediated knockdown of either the RRM1 or RRM2 subunit sensitizes cells to the cytotoxic effects of the nucleoside analogs and more recently it has been shown that RRM2 knockdown itself has a growth inhibitory effect.	Nucleosides	141-151	ribonucleotide reductase regulatory subunit M2	Homo sapiens	201-205
19194315-7	2009	HIV men on dual nucleoside ART had significantly higher seminal MO, CD4, and CD8 T-cell counts than ART HIV men; addition of indinavir led to a dramatic (>25-fold, P < 0.001) increase in seminal CD4 T-cell counts which paralleled an increase in blood CD4 cell counts.	Nucleosides	16-26	CD4 molecule	Homo sapiens	68-71
19194315-7	2009	HIV men on dual nucleoside ART had significantly higher seminal MO, CD4, and CD8 T-cell counts than ART HIV men; addition of indinavir led to a dramatic (>25-fold, P < 0.001) increase in seminal CD4 T-cell counts which paralleled an increase in blood CD4 cell counts.	Nucleosides	16-26	CD8a molecule	Homo sapiens	77-80
19098160-1	2009	The human concentrative nucleoside transporter 2 (CNT2) plays an important role in the absorption, disposition, and biological effects of endogenous nucleosides and nucleoside analog drugs.	Nucleosides	149-160	solute carrier family 28 member 2	Homo sapiens	10-48
19098160-1	2009	The human concentrative nucleoside transporter 2 (CNT2) plays an important role in the absorption, disposition, and biological effects of endogenous nucleosides and nucleoside analog drugs.	Nucleosides	149-160	solute carrier family 28 member 2	Homo sapiens	50-54
19098160-1	2009	The human concentrative nucleoside transporter 2 (CNT2) plays an important role in the absorption, disposition, and biological effects of endogenous nucleosides and nucleoside analog drugs.	Nucleosides	24-34	solute carrier family 28 member 2	Homo sapiens	50-54
19883017-1	2009	Some nucleoside analogs display significant activity against malignancies (gemcitabine, cytarabine) or viruses (ddl, ddC, AZT) by interfering with DNA synthesis.	Nucleosides	5-15	dopa decarboxylase	Homo sapiens	117-120
19056916-9	2009	The nucleoside substrates zidovudine and abacavir seem to bind to a region on BCRP that may have little or no overlap with the binding regions of either prazosin or imatinib.	Nucleosides	4-14	ATP binding cassette subfamily G member 2	Canis lupus familiaris	78-82
19159229-1	2009	Salvage of nucleosides in the cytosol of human cells is carried out by deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1).	Nucleosides	11-22	deoxycytidine kinase	Homo sapiens	71-91
19159229-1	2009	Salvage of nucleosides in the cytosol of human cells is carried out by deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1).	Nucleosides	11-22	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	93-96
19159229-1	2009	Salvage of nucleosides in the cytosol of human cells is carried out by deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1).	Nucleosides	11-22	thymidine kinase 1	Homo sapiens	102-120
19159229-1	2009	Salvage of nucleosides in the cytosol of human cells is carried out by deoxycytidine kinase (dCK) and thymidine kinase 1 (TK1).	Nucleosides	11-22	thymidine kinase 1	Homo sapiens	122-125
19283279-7	2009	Other biomolecules, including nucleosides, carbohydrates, folic acid and vitamin B12 are also readily modified using analogous methods.	Nucleosides	30-41	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	81-84
19177436-11	2009	In conclusion, nucleoside analog therapy is nearly always used for anti-HBc-positive livers, and most transplant physicians treat for an indefinite period.	Nucleosides	15-25	keratin 88, pseudogene	Homo sapiens	72-75
19073137-1	2009	Multidrug resistance protein 4 (MRP4/ABCC4), a member of the ATP-binding cassette protein superfamily, confers resistance to nucleoside and nucleotide analogs as well as camptothecin derivatives.	Nucleosides	125-135	ATP binding cassette subfamily C member 4	Homo sapiens	32-36
19073137-1	2009	Multidrug resistance protein 4 (MRP4/ABCC4), a member of the ATP-binding cassette protein superfamily, confers resistance to nucleoside and nucleotide analogs as well as camptothecin derivatives.	Nucleosides	125-135	ATP binding cassette subfamily C member 4	Homo sapiens	37-42
19116148-6	2009	These results define G24 as critical amino acid for ENT1 nucleoside uptake and suggest that mutations in TM1 may provide a mechanism for Ara-C resistance in CCRF-CEM Ara-C/8C cells.	Nucleosides	57-67	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	52-56
19118001-0	2009	Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B.	Nucleosides	73-83	ATP binding cassette subfamily C member 10	Homo sapiens	6-36
19118001-9	2009	These experiments indicate that the resistance capabilities of MRP7 include nucleoside-based agents and a range of natural product anticancer agents that includes nontaxane antimicrotubule agents that are not susceptible to P-glycoprotein-mediated transport and that, unlike MRP1 and MRP2, MRP7-mediated drug transport does not involve glutathione.	Nucleosides	76-86	ATP binding cassette subfamily C member 10	Homo sapiens	63-67
18500522-8	2009	Variations in hCNT3 abundance in renal proximal tubules, and hence nucleoside reabsorption, may explain interpatient variability in fludarabine"s pharmacokinetics and toxicities.	Nucleosides	67-77	solute carrier family 28 member 3	Homo sapiens	14-19
19118001-0	2009	Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B.	Nucleosides	73-83	ATP binding cassette subfamily C member 10	Homo sapiens	38-44
19118001-3	2009	Here, it is shown by the analysis of MRP7-transfected HEK293 cells that, in addition to natural product agents, MRP7 is also able to confer resistance to nucleoside-based agents, such as the anticancer agents cytarabine (Ara-C) and gemcitabine, and the antiviral agents 2",3"-dideoxycytidine and PMEA.	Nucleosides	154-164	ATP binding cassette subfamily C member 10	Homo sapiens	37-41
19118001-3	2009	Here, it is shown by the analysis of MRP7-transfected HEK293 cells that, in addition to natural product agents, MRP7 is also able to confer resistance to nucleoside-based agents, such as the anticancer agents cytarabine (Ara-C) and gemcitabine, and the antiviral agents 2",3"-dideoxycytidine and PMEA.	Nucleosides	154-164	ATP binding cassette subfamily C member 10	Homo sapiens	112-116
18981770-1	2008	OBJECTIVES: Thymidine-based nucleoside analogue reverse transcriptase inhibitors and some protease inhibitors of HIV are associated with lipoatrophy, relative central fat accumulation and insulin resistance.	Nucleosides	28-38	insulin	Homo sapiens	188-195
19430172-1	2009	The human concentrative nucleoside transporter 2 (hCNT2) plays a major role in the intestinal absorption of naturally occurring nucleosides as well as some nucleoside analog drugs.	Nucleosides	128-139	solute carrier family 28 member 2	Homo sapiens	10-48
19430172-1	2009	The human concentrative nucleoside transporter 2 (hCNT2) plays a major role in the intestinal absorption of naturally occurring nucleosides as well as some nucleoside analog drugs.	Nucleosides	128-139	solute carrier family 28 member 2	Homo sapiens	50-55
19430172-1	2009	The human concentrative nucleoside transporter 2 (hCNT2) plays a major role in the intestinal absorption of naturally occurring nucleosides as well as some nucleoside analog drugs.	Nucleosides	24-34	solute carrier family 28 member 2	Homo sapiens	50-55
19749284-0	2009	The use of conformationally rigid nucleoside probes to study the role of sugar pucker and nucleobase orientation in the thrombin binding aptamer.	Nucleosides	34-44	coagulation factor II, thrombin	Homo sapiens	120-128
19749284-3	2009	The substitution at position 14 with a locked South/syn-dG nucleoside produced an aptamer with the same stability and global structure as the innate, unmodified one.	Nucleosides	59-69	synemin	Homo sapiens	52-55
19010910-6	2008	Consistent with this idea, only nucleoside-based DNMT inhibitors that form covalent DNA adducts induce p53R2 expression.	Nucleosides	32-42	DNA methyltransferase 1	Homo sapiens	49-53
19010910-6	2008	Consistent with this idea, only nucleoside-based DNMT inhibitors that form covalent DNA adducts induce p53R2 expression.	Nucleosides	32-42	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Homo sapiens	103-108
18827020-9	2009	We suggest that this novel hCNT3 isoform would be involved in the salvage of intracellular nucleosides from the lumen of the endoplasmic reticulum to the cytoplasm.	Nucleosides	91-102	solute carrier family 28 member 3	Homo sapiens	27-32
19077268-5	2008	Interestingly, LUF6000 converted a nucleoside A3 AR antagonist MRS542, but not a non-nucleoside antagonist MRS1220, into an agonist.	Nucleosides	35-45	adenosine A3 receptor	Homo sapiens	46-51
18991621-0	2008	Nucleoside-free boosted double PI regimen: significant CD4+ T-cell recovery in patients with poor immunologic response despite virologic suppression.	Nucleosides	0-10	CD4 molecule	Homo sapiens	55-58
18991621-2	2008	As some combinations of nucleoside analogues (NA) have been associated with paradoxical depletion of CD4(+) T- cells, we postulated that depleting the antiretroviral regimen of NAs would improve quantitative immunological parameters.	Nucleosides	24-34	CD4 molecule	Homo sapiens	101-104
18805697-2	2008	The conformations (syn vs anti) of the three modified nucleosides and cytidine were determined by CD and 1D NOE difference spectroscopy.	Nucleosides	54-65	synemin	Homo sapiens	19-22
18668436-2	2008	hCNT1 and hCNT2 translocate pyrimidine- and purine-nucleosides, respectively, by a sodium-dependent mechanism, whereas hCNT3 shows broad substrate selectivity and the unique ability of translocating nucleosides both in a sodium- and a proton-coupled manner.	Nucleosides	51-62	solute carrier family 28 member 1	Homo sapiens	0-5
18829552-0	2008	ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.	Nucleosides	48-58	ATM serine/threonine kinase	Homo sapiens	0-3
18829552-0	2008	ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.	Nucleosides	48-58	MRE11 homolog, double strand break repair nuclease	Homo sapiens	12-17
18621735-1	2008	In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purine and pyrimidine nucleosides and nucleoside drugs.	Nucleosides	35-45	solute carrier family 28 member 1	Homo sapiens	130-134
18621735-1	2008	In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purine and pyrimidine nucleosides and nucleoside drugs.	Nucleosides	35-45	solute carrier family 28 member 1	Homo sapiens	136-141
18621735-1	2008	In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purine and pyrimidine nucleosides and nucleoside drugs.	Nucleosides	35-45	solute carrier family 28 member 2	Homo sapiens	147-152
18621735-1	2008	In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purine and pyrimidine nucleosides and nucleoside drugs.	Nucleosides	35-45	solute carrier family 28 member 3	Homo sapiens	223-228
18621735-1	2008	In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purine and pyrimidine nucleosides and nucleoside drugs.	Nucleosides	179-189	solute carrier family 28 member 1	Homo sapiens	130-134
18621735-1	2008	In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purine and pyrimidine nucleosides and nucleoside drugs.	Nucleosides	179-189	solute carrier family 28 member 1	Homo sapiens	136-141
18621735-1	2008	In humans, the SLC28 concentrative nucleoside transporter (CNT) protein family is represented by three Na+-coupled members; human CNT1 (hCNT1) and hCNT2 are pyrimidine and purine nucleoside-selective, respectively, whereas hCNT3 transports both purine and pyrimidine nucleosides and nucleoside drugs.	Nucleosides	179-189	solute carrier family 28 member 2	Homo sapiens	147-152
18752966-2	2008	A series of modified thrombin binding aptamers (TBAs) in which the new acyclic nucleoside replaces, one at the time, the thymidine residues were then synthesized and characterized by UV, CD, MS, and (1)H NMR.	Nucleosides	79-89	coagulation factor II, thrombin	Homo sapiens	21-29
18459168-5	2008	TK2 activity could also be involved in mitochondrial toxicity associated to prolonged treatment with antiviral nucleoside analogues like AZT and FIAU.	Nucleosides	111-121	thymidine kinase 2	Homo sapiens	0-3
18459168-7	2008	Highly selective TK-2 inhibitors having an acyclic nucleoside structure and efficiently discriminating between TK-2 and the closely related TK-1 have already been reported.	Nucleosides	51-61	thymidine kinase 2	Homo sapiens	17-21
18765824-0	2008	Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides.	Nucleosides	111-122	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	37-42
18765824-0	2008	Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides.	Nucleosides	111-122	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	44-76
18765824-1	2008	We have studied the potential contribution of ABCG2 (breast cancer resistance protein) to resistance to nucleoside analogues.	Nucleosides	104-114	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	46-51
18765824-1	2008	We have studied the potential contribution of ABCG2 (breast cancer resistance protein) to resistance to nucleoside analogues.	Nucleosides	104-114	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	53-85
18765824-5	2008	The high transport rate of cladribine and clofarabine by ABCG2 deduced from Transwell experiments raises the possibility that this transporter could affect the disposition of nucleoside analogues in patients or cause resistance in tumors.	Nucleosides	175-185	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	57-62
18829552-0	2008	ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.	Nucleosides	48-58	RAD50 double strand break repair protein	Homo sapiens	18-23
18829552-0	2008	ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance.	Nucleosides	48-58	nibrin	Homo sapiens	24-28
18829552-7	2008	Using gamma-H2AX as a marker for changes in chromatin structure, we show that Mre11, Rad50, Nbs1, and phosphorylated ATM respond to nucleoside analogue-induced stalled replication forks by forming nuclear foci that colocalize with gamma-H2AX within 2 hours.	Nucleosides	132-142	H2A.X variant histone	Homo sapiens	12-16
18829552-7	2008	Using gamma-H2AX as a marker for changes in chromatin structure, we show that Mre11, Rad50, Nbs1, and phosphorylated ATM respond to nucleoside analogue-induced stalled replication forks by forming nuclear foci that colocalize with gamma-H2AX within 2 hours.	Nucleosides	132-142	MRE11 homolog, double strand break repair nuclease	Homo sapiens	78-83
18829552-7	2008	Using gamma-H2AX as a marker for changes in chromatin structure, we show that Mre11, Rad50, Nbs1, and phosphorylated ATM respond to nucleoside analogue-induced stalled replication forks by forming nuclear foci that colocalize with gamma-H2AX within 2 hours.	Nucleosides	132-142	RAD50 double strand break repair protein	Homo sapiens	85-90
18829552-7	2008	Using gamma-H2AX as a marker for changes in chromatin structure, we show that Mre11, Rad50, Nbs1, and phosphorylated ATM respond to nucleoside analogue-induced stalled replication forks by forming nuclear foci that colocalize with gamma-H2AX within 2 hours.	Nucleosides	132-142	nibrin	Homo sapiens	92-96
18829552-7	2008	Using gamma-H2AX as a marker for changes in chromatin structure, we show that Mre11, Rad50, Nbs1, and phosphorylated ATM respond to nucleoside analogue-induced stalled replication forks by forming nuclear foci that colocalize with gamma-H2AX within 2 hours.	Nucleosides	132-142	ATM serine/threonine kinase	Homo sapiens	117-120
18829552-7	2008	Using gamma-H2AX as a marker for changes in chromatin structure, we show that Mre11, Rad50, Nbs1, and phosphorylated ATM respond to nucleoside analogue-induced stalled replication forks by forming nuclear foci that colocalize with gamma-H2AX within 2 hours.	Nucleosides	132-142	H2A.X variant histone	Homo sapiens	237-241
18755836-5	2008	The E. coli ybeA gene deletion strain lacks the N3 methylation at position 1915 of 23S rRNA as revealed by primer extension and nucleoside analysis by HPLC.	Nucleosides	128-138	hypothetical protein	Escherichia coli	12-16
18459168-7	2008	Highly selective TK-2 inhibitors having an acyclic nucleoside structure and efficiently discriminating between TK-2 and the closely related TK-1 have already been reported.	Nucleosides	51-61	thymidine kinase 2	Homo sapiens	111-115
18459168-7	2008	Highly selective TK-2 inhibitors having an acyclic nucleoside structure and efficiently discriminating between TK-2 and the closely related TK-1 have already been reported.	Nucleosides	51-61	thymidine kinase 1	Homo sapiens	140-144
18549808-3	2008	From the crystal structures with various ligands, the non-nucleoside type inhibitors bind to the active site occupying the critical water-binding-position and sustain the open form of apo-ADA.	Nucleosides	58-68	adenosine deaminase	Homo sapiens	188-191
18589402-4	2008	Overexpression of hENT1 is associated with changes in cell cycle profile, in a variable manner depending on the particular cell type, thus suggesting a metabolic link between hENT1-mediated transport processes and the enzymatic machinery responsible for intracellular nucleoside metabolism.	Nucleosides	268-278	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	18-23
18589402-4	2008	Overexpression of hENT1 is associated with changes in cell cycle profile, in a variable manner depending on the particular cell type, thus suggesting a metabolic link between hENT1-mediated transport processes and the enzymatic machinery responsible for intracellular nucleoside metabolism.	Nucleosides	268-278	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	175-180
18589402-6	2008	In summary, hENT1 overexpression is associated with alterations in nucleoside enzymatic machinery and cell cycle progression in cultured cells and enhances gemcitabine action in vivo.	Nucleosides	67-77	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	12-17
18598087-4	2008	In contrast to the known carbohydrate-based synthetic routes to the above furopyranyl fragment, the present amino acid chiral template approach is expected to offer a more flexible pathway toward potential SAR-targeted structural/stereochemical modifications of this central bicyclic nucleoside component of the ezomycins.	Nucleosides	284-294	sarcosine dehydrogenase	Homo sapiens	206-209
18593894-4	2008	We show that multidrug-resistance protein 4 (Mrp4) is abundant in myeloid progenitors and tested the role of the Mrp4, an ATP transporter of monophosphorylated nucleosides, in this unexplained thiopurine sensitivity.	Nucleosides	160-171	ATP binding cassette subfamily C member 4	Homo sapiens	113-117
18668437-7	2008	hENT3 has a similar broad permeant selectivity for nucleosides and nucleobases and appears to function in intracellular membranes, including lysosomes.	Nucleosides	51-62	solute carrier family 29 member 3	Homo sapiens	0-5
18668436-2	2008	hCNT1 and hCNT2 translocate pyrimidine- and purine-nucleosides, respectively, by a sodium-dependent mechanism, whereas hCNT3 shows broad substrate selectivity and the unique ability of translocating nucleosides both in a sodium- and a proton-coupled manner.	Nucleosides	51-62	solute carrier family 28 member 2	Homo sapiens	10-15
18668436-2	2008	hCNT1 and hCNT2 translocate pyrimidine- and purine-nucleosides, respectively, by a sodium-dependent mechanism, whereas hCNT3 shows broad substrate selectivity and the unique ability of translocating nucleosides both in a sodium- and a proton-coupled manner.	Nucleosides	199-210	solute carrier family 28 member 1	Homo sapiens	0-5
18668436-2	2008	hCNT1 and hCNT2 translocate pyrimidine- and purine-nucleosides, respectively, by a sodium-dependent mechanism, whereas hCNT3 shows broad substrate selectivity and the unique ability of translocating nucleosides both in a sodium- and a proton-coupled manner.	Nucleosides	199-210	solute carrier family 28 member 2	Homo sapiens	10-15
18668436-2	2008	hCNT1 and hCNT2 translocate pyrimidine- and purine-nucleosides, respectively, by a sodium-dependent mechanism, whereas hCNT3 shows broad substrate selectivity and the unique ability of translocating nucleosides both in a sodium- and a proton-coupled manner.	Nucleosides	199-210	solute carrier family 28 member 3	Homo sapiens	119-124
18583930-1	2008	We previously described the identification of a nucleoside analog transcriptional inhibitor ARC (4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-Pyrrolo[2,3-d]-pyrimidine-5-carboxamide) and FoxM1 inhibitor, thiazole antibiotic Siomycin A that were able to induce apoptosis in cancer cell lines of different origin.	Nucleosides	48-58	forkhead box M1	Homo sapiens	188-193
18560576-7	2008	Moreover, HDAC inhibitor showed selective synergy with nucleoside analog-induced DNA damage to inhibit cell proliferation, but showed no such effect with other DNA damage stresses such as gamma-ray and UV, etoposide or cisplatin.	Nucleosides	55-65	histone deacetylase 9	Homo sapiens	10-14
18325606-8	2008	Taken together, these data provided direct evidence that PCV is a potent selective inhibitor of FHV-1 and that the virus-encoded TK is an important determinant of the virus susceptibility to nucleoside analogues.	Nucleosides	191-201	thymidine kinase	Felid alphaherpesvirus 1	129-131
18559527-1	2008	Multidrug resistance protein 4 (MRP4; ABCC4) is a member of the ATP-binding cassette superfamily of membrane transport proteins and confers resistance to nucleoside and nucleotide analogues as well as camptothecin derivatives.	Nucleosides	154-164	ATP binding cassette subfamily C member 4	Homo sapiens	0-30
18559527-1	2008	Multidrug resistance protein 4 (MRP4; ABCC4) is a member of the ATP-binding cassette superfamily of membrane transport proteins and confers resistance to nucleoside and nucleotide analogues as well as camptothecin derivatives.	Nucleosides	154-164	ATP binding cassette subfamily C member 4	Homo sapiens	32-36
18559527-1	2008	Multidrug resistance protein 4 (MRP4; ABCC4) is a member of the ATP-binding cassette superfamily of membrane transport proteins and confers resistance to nucleoside and nucleotide analogues as well as camptothecin derivatives.	Nucleosides	154-164	ATP binding cassette subfamily C member 4	Homo sapiens	38-43
18493683-11	2008	The mass limit of detection was 15 pg, corresponding to a concentration limit of detection of 75 fg mul(-1) DNA hydrolysate solution, corresponding to 48 adducts per 10(6) normal nucleosides.	Nucleosides	179-190	mitochondrial E3 ubiquitin protein ligase 1	Bos taurus	100-106
18286491-1	2008	BACKGROUND: 3"-18F-fluoro-3"-deoxy-fluorothymidine (18F-FLT), a nucleoside analog, could monitor effects of molecularly targeted therapeutics on tumor proliferation.	Nucleosides	64-74	fms related receptor tyrosine kinase 1	Homo sapiens	56-59
19338072-8	2008	TDF can also be a good choice for substituting another nucleoside analogue to avoid or reverse certain toxicities in patients with good virological control.	Nucleosides	55-65	sex determining region Y	Homo sapiens	0-3
18424636-4	2008	Flux of nucleosides, such as adenosine and inosine, across cardiomyocyte membranes is dependent on equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2).	Nucleosides	8-19	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	146-150
18424636-4	2008	Flux of nucleosides, such as adenosine and inosine, across cardiomyocyte membranes is dependent on equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2).	Nucleosides	8-19	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	155-159
18248612-6	2008	In cerebellar granule neurons, purine nucleosides induced an up to 3.1-fold HIF-1alpha accumulation in cell lysates.	Nucleosides	38-49	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	76-86
18600540-5	2008	Although, imatinib-resistant cells showed decreased levels of both ENT1 and ENT2 activity and expression, these cells remained sensitive to gemcitabine, suggesting that nucleoside analogs can be used as adjunctive therapy.	Nucleosides	169-179	solute carrier family 29 member 2	Homo sapiens	76-80
18377927-3	2008	Several nucleoside analog prodrugs are dependent on dCK for their pharmacological activation, and even nucleosides of the non-physiological L-chirality are phosphorylated by dCK.	Nucleosides	8-18	sticky	Drosophila melanogaster	52-55
18426922-0	2008	Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner.	Nucleosides	0-10	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	67-70
18426922-9	2008	In the case of dsRNA, a more limited set of nucleoside modifications affect PKR activation.	Nucleosides	44-54	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	76-79
18377927-3	2008	Several nucleoside analog prodrugs are dependent on dCK for their pharmacological activation, and even nucleosides of the non-physiological L-chirality are phosphorylated by dCK.	Nucleosides	103-114	sticky	Drosophila melanogaster	174-177
18600530-1	2008	Resistance toward nucleoside analogues is often due to decreased activities of the activating enzymes deoxycytidine kinase (dCK) and/or deoxyguanosine kinase (dGK).	Nucleosides	18-28	deoxycytidine kinase	Homo sapiens	102-122
18600530-1	2008	Resistance toward nucleoside analogues is often due to decreased activities of the activating enzymes deoxycytidine kinase (dCK) and/or deoxyguanosine kinase (dGK).	Nucleosides	18-28	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	124-127
18600530-1	2008	Resistance toward nucleoside analogues is often due to decreased activities of the activating enzymes deoxycytidine kinase (dCK) and/or deoxyguanosine kinase (dGK).	Nucleosides	18-28	deoxyguanosine kinase	Homo sapiens	136-157
18600530-1	2008	Resistance toward nucleoside analogues is often due to decreased activities of the activating enzymes deoxycytidine kinase (dCK) and/or deoxyguanosine kinase (dGK).	Nucleosides	18-28	Diacyl glycerol kinase	Drosophila melanogaster	159-162
18600530-2	2008	With small interfering RNA (siRNA), dCK and dGK were downregulated by approximately 70% in CEM cells and tested against six nucleoside analogues using the methyl thiazol tetrazolium assay.	Nucleosides	124-134	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	36-39
18600530-2	2008	With small interfering RNA (siRNA), dCK and dGK were downregulated by approximately 70% in CEM cells and tested against six nucleoside analogues using the methyl thiazol tetrazolium assay.	Nucleosides	124-134	Diacyl glycerol kinase	Drosophila melanogaster	44-47
18377927-4	2008	In addition to accepting dC and purine nucleosides (and their analogs) as phosphoryl acceptors, dCK can utilize either ATP or UTP as phosphoryl donors.	Nucleosides	39-50	sticky	Drosophila melanogaster	96-99
18377927-5	2008	To unravel the structural basis for substrate promiscuity of dCK at both the nucleoside acceptor and nucleotide donor sites, we solved the crystal structures of the enzyme as ternary complexes with the two enantiomeric forms of dA (D-dA, or L-dA), with either UDP or ADP bound to the donor site.	Nucleosides	77-87	sticky	Drosophila melanogaster	61-64
18377927-6	2008	The complexes with UDP revealed an open state of dCK in which the nucleoside, either D-dA or L-dA, is surprisingly bound in a manner not consistent with catalysis.	Nucleosides	66-76	sticky	Drosophila melanogaster	49-52
18377927-3	2008	Several nucleoside analog prodrugs are dependent on dCK for their pharmacological activation, and even nucleosides of the non-physiological L-chirality are phosphorylated by dCK.	Nucleosides	8-18	sticky	Drosophila melanogaster	174-177
18454043-7	2008	Compounds currently under development that seek to inhibit hTERT, the reverse transcriptase component of telomerase, include nucleoside analogs and the small molecule BIBR1532.	Nucleosides	125-135	telomerase reverse transcriptase	Homo sapiens	59-64
18384378-0	2008	Structural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.	Nucleosides	22-32	deoxyribonucleoside kinase	Drosophila melanogaster	113-139
18384378-4	2008	In this study we present crystal structures of dNK complexed with four different nucleoside analogs (floxuridine, brivudine, zidovudine and zalcitabine) and relate them to the binding of substrate and feedback inhibitors.	Nucleosides	81-91	deoxyribonucleoside kinase	Drosophila melanogaster	47-50
18361501-1	2008	Human deoxycytidine kinase (dCK) is responsible for the phosphorylation of a number of clinically important nucleoside analogue prodrugs in addition to its natural substrates, 2"-deoxycytidine, 2"-deoxyguanosine, and 2"-deoxyadenosine.	Nucleosides	108-118	deoxycytidine kinase	Homo sapiens	6-26
18361501-1	2008	Human deoxycytidine kinase (dCK) is responsible for the phosphorylation of a number of clinically important nucleoside analogue prodrugs in addition to its natural substrates, 2"-deoxycytidine, 2"-deoxyguanosine, and 2"-deoxyadenosine.	Nucleosides	108-118	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	28-31
18413388-3	2008	PET of HSV1-tk reporter gene expression will be compromised in patients receiving nucleoside-based antiviral treatment.	Nucleosides	82-92	thyroid stimulating hormone receptor	Mus musculus	0-3
18336835-3	2008	Individual modified nucleosides have pronounced effects on the structural dynamics of tRNA and the EF-Tu.Cys-tRNA(Cys) interface.	Nucleosides	20-31	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	99-104
18216183-6	2008	Among purine and pyrimidine nucleobases, nucleosides, and nucleotides, hOAT2 showed the greatest preference for cGMP, which transported cGMP with a K(m) value of 88 +/- 11 muM and exhibited between 50- and 100-fold enhanced uptake over control cells.	Nucleosides	41-52	solute carrier family 22 member 7	Homo sapiens	71-76
18404573-1	2008	A stereoselective synthetic route has been developed for the combinatorial synthesis of a structurally unique class of C-4" side chain modified peptide-linked nucleosides.	Nucleosides	159-170	complement C4A (Rodgers blood group)	Homo sapiens	119-122
18436149-3	2008	Given the association of polymorphonuclear leukocytes (PMNs) with adenine nucleotide/nucleoside signaling in the inflammatory milieu, it was recently demonstrated that PMNs actively release ATP via a connexin 43 hemichannel-dependent mechanism.	Nucleosides	85-95	gap junction protein alpha 1	Homo sapiens	200-211
18280798-4	2008	The identification of the correct mitochondrial DNC is important for research on the genetic diseases of mitochondrial DNA maintenance and the toxicity experienced by many HIV patients undergoing antiretroviral therapy involving nucleoside analogs.	Nucleosides	229-239	solute carrier family 25 member 19	Homo sapiens	48-51
18078759-3	2008	Functional group composition and chain length were shown to have only a subtle influence on the distribution of syn/anti conformations of the modified nucleosides.	Nucleosides	151-162	synemin	Homo sapiens	112-115
18078872-3	2008	IL-4 is a pro-survival signal for chronic lymphocytic leukemia (CLL) cells and has been shown to confer resistance to nucleoside analogs.	Nucleosides	118-128	interleukin 4	Homo sapiens	0-4
18078872-4	2008	The aim of this study was to investigate whether IL-4 is able to modulate the expression and function of the human equilibrative NT1 (hENT1) in primary cultures of CLL cells and, consequently, to affect cytotoxicity induced by therapeutic nucleosides analogs.	Nucleosides	239-250	interleukin 4	Homo sapiens	49-53
18078872-4	2008	The aim of this study was to investigate whether IL-4 is able to modulate the expression and function of the human equilibrative NT1 (hENT1) in primary cultures of CLL cells and, consequently, to affect cytotoxicity induced by therapeutic nucleosides analogs.	Nucleosides	239-250	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	134-139
17980347-1	2008	Powerful capillary electrophoresis (CE) methods were developed for monitoring the reaction of ecto-5"-nucleotidase (ecto-5"-NT, CD73), a (patho)biochemically important enzyme that hydrolyzes nucleoside-5"-monophosphates to the corresponding nucleosides.	Nucleosides	241-252	5'-nucleotidase ecto	Homo sapiens	94-114
17980347-1	2008	Powerful capillary electrophoresis (CE) methods were developed for monitoring the reaction of ecto-5"-nucleotidase (ecto-5"-NT, CD73), a (patho)biochemically important enzyme that hydrolyzes nucleoside-5"-monophosphates to the corresponding nucleosides.	Nucleosides	241-252	5'-nucleotidase ecto	Homo sapiens	116-126
17980347-1	2008	Powerful capillary electrophoresis (CE) methods were developed for monitoring the reaction of ecto-5"-nucleotidase (ecto-5"-NT, CD73), a (patho)biochemically important enzyme that hydrolyzes nucleoside-5"-monophosphates to the corresponding nucleosides.	Nucleosides	241-252	5'-nucleotidase ecto	Homo sapiens	128-132
17993510-3	2008	The resulting hCNT3(C602R) protein has the same selectivity and affinity for natural nucleosides and nucleoside-derived drugs as hCNT3 but much lower concentrative capacity.	Nucleosides	85-96	solute carrier family 28 member 3	Homo sapiens	14-19
18098126-3	2008	CD39 is the dominant cellular ectonucleotidase that degrades nucleotides to nucleosides, including adenosine.	Nucleosides	76-87	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	0-4
18053967-8	2008	To confirm the role of hCNT1 in 5"-DFUR treatment, a panel of nucleoside derivatives suitable for hCNT1-inhibition was obtained.	Nucleosides	62-72	solute carrier family 28 member 1	Homo sapiens	98-103
18053967-10	2008	Furthermore, the cytotoxic action of 5"-DFUR and the transcriptional changes produced by this nucleoside analogue were partially inhibited by T-Ala in MCF7-hCNT1 cells.	Nucleosides	94-104	solute carrier family 28 member 1	Homo sapiens	156-161
17977830-2	2008	However, whether cellular responses to nucleoside analogue-induced DNA damage also operate through p53 posttranslational modification has not been reported.	Nucleosides	39-49	tumor protein p53	Homo sapiens	99-102
17993510-7	2008	The sodium activation kinetic analysis of both transporters revealed a variation in the affinity for sodium and a shift in the Hill coefficient that could be consistent with a stoichiometry of 2:1 and 1:1 sodium/nucleoside, for hCNT3 and hCNT3(C602R), respectively.	Nucleosides	212-222	solute carrier family 28 member 3	Homo sapiens	228-233
17993510-7	2008	The sodium activation kinetic analysis of both transporters revealed a variation in the affinity for sodium and a shift in the Hill coefficient that could be consistent with a stoichiometry of 2:1 and 1:1 sodium/nucleoside, for hCNT3 and hCNT3(C602R), respectively.	Nucleosides	212-222	solute carrier family 28 member 3	Homo sapiens	238-243
17993510-9	2008	Individuals with the hCNT3(C602R) variant might show a lower nucleoside and nucleoside analog concentrative capacity, which could be clinically relevant.	Nucleosides	61-71	solute carrier family 28 member 3	Homo sapiens	21-26
17993510-9	2008	Individuals with the hCNT3(C602R) variant might show a lower nucleoside and nucleoside analog concentrative capacity, which could be clinically relevant.	Nucleosides	76-86	solute carrier family 28 member 3	Homo sapiens	21-26
17993510-3	2008	The resulting hCNT3(C602R) protein has the same selectivity and affinity for natural nucleosides and nucleoside-derived drugs as hCNT3 but much lower concentrative capacity.	Nucleosides	85-95	solute carrier family 28 member 3	Homo sapiens	14-19
18092770-8	2008	The close similarity between energetic and geometric characteristics of dU and thymidine DNA-like conformers in anti and relevant syn conformations and their transition states of the anti-->syn interconversion implies that mismatch DNA glycosylase discriminates between the two nucleosides, mainly because of the difference in the shapes of their bases.	Nucleosides	281-292	synemin	Homo sapiens	130-133
18092770-8	2008	The close similarity between energetic and geometric characteristics of dU and thymidine DNA-like conformers in anti and relevant syn conformations and their transition states of the anti-->syn interconversion implies that mismatch DNA glycosylase discriminates between the two nucleosides, mainly because of the difference in the shapes of their bases.	Nucleosides	281-292	synemin	Homo sapiens	193-196
17999954-8	2008	It also phosphorylated the monophosphate forms of the nucleoside analogs ddC, dFdC, araC, BVDU, and FdUrd, which suggests that UMP-CMPK2 may be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs.	Nucleosides	54-64	cytidine/uridine monophosphate kinase 2	Homo sapiens	127-136
17949751-3	2008	Oxidative products to nucleosides, 8-hydroxy-2"-deoxyguanosine and 8-hydroxyguanosine, were accumulated in the lenticulate nucleus predominantly in DRPLA cases having PME.	Nucleosides	22-33	atrophin 1	Homo sapiens	148-153
18037401-0	2008	Comparison of the induction of P-glycoprotein activity by nucleotide, nucleoside, and non-nucleoside reverse transcriptase inhibitors.	Nucleosides	70-80	ATP binding cassette subfamily B member 1	Homo sapiens	31-45
18610555-10	2008	CONCLUSION: These promising in vitro data warrant clinical investigation of the nucleosides analogues such as 2"-C-MeC or 2"-F-C-MeC in their prodrug forms, together with IFN-alphac2b and RBV, for successful treatment of HCV infections.	Nucleosides	80-91	C-C motif chemokine ligand 28	Homo sapiens	115-118
18610555-10	2008	CONCLUSION: These promising in vitro data warrant clinical investigation of the nucleosides analogues such as 2"-C-MeC or 2"-F-C-MeC in their prodrug forms, together with IFN-alphac2b and RBV, for successful treatment of HCV infections.	Nucleosides	80-91	C-C motif chemokine ligand 28	Homo sapiens	129-132
17868038-9	2008	Variations seen in the inhibition by nucleosides and nucleotide analogues between human GMPS and PfGMPS highlighted differences in ligand specificity that could serve as a basis for the design of specific inhibitors.	Nucleosides	37-48	guanine monophosphate synthase	Homo sapiens	88-92
18833553-1	2008	The relative configuration at C-6" of nucleoside antibiotic miharamycin A has been elucidated by NMR spectroscopy and proved to be S. The total synthesis of miharamycin B has also been investigated, which has led to the unprecedented construction of its core.	Nucleosides	38-48	complement C6	Homo sapiens	30-33
18974616-1	2008	Deoxycytidine kinase (dCK) is a rate-limiting enzyme in the activation of nucleoside anticancer drugs, such as gemcitabine and cytarabine (Ara-C), to their active metabolites.	Nucleosides	74-84	deoxycytidine kinase	Homo sapiens	0-20
18691054-8	2008	In vitro, the MRP/ABCC transporters can collectively confer resistance to natural product anticancer drugs and their conjugated metabolites, platinum compounds, folate antimetabolites, nucleoside and nucleotide analogs, arsenical and antimonial oxyanions, peptide-based agents, and in concert with alterations in phase II conjugating or biosynthetic enzymes, classical alkylating agents, alkylating agents.	Nucleosides	185-195	ATP binding cassette subfamily C member 1	Homo sapiens	14-17
18691054-8	2008	In vitro, the MRP/ABCC transporters can collectively confer resistance to natural product anticancer drugs and their conjugated metabolites, platinum compounds, folate antimetabolites, nucleoside and nucleotide analogs, arsenical and antimonial oxyanions, peptide-based agents, and in concert with alterations in phase II conjugating or biosynthetic enzymes, classical alkylating agents, alkylating agents.	Nucleosides	185-195	ATP binding cassette subfamily C member 1	Homo sapiens	18-22
18974616-1	2008	Deoxycytidine kinase (dCK) is a rate-limiting enzyme in the activation of nucleoside anticancer drugs, such as gemcitabine and cytarabine (Ara-C), to their active metabolites.	Nucleosides	74-84	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
19056541-0	2008	Assessment of expression of selected Bcl-2 family proteins in lymphoid infiltration in patients with B-cell chronic lymphocytic leukaemia treated with nucleoside analogues.	Nucleosides	151-161	BCL2 apoptosis regulator	Homo sapiens	37-42
18587708-1	2008	Cytidine-5-diphosphocholine (CDP-choline, citicoline) is an endogenous nucleoside involved in generation of phospholipids, membrane formation and its repair.	Nucleosides	71-81	cut-like homeobox 1	Rattus norvegicus	29-32
19056541-4	2008	The aim of the study was to assess expression of selected Bcl-2 family proteins in neoplastic infiltration in bone marrow in patients with B-CLL treated with nucleoside analogues.	Nucleosides	158-168	BCL2 apoptosis regulator	Homo sapiens	58-63
18084067-2	2007	The structures of dCK alone and the dead-end complex of dCK with substrate nucleoside and product ADP or UDP have previously been reported; however, there is currently no structure available for a substrate or product complex.	Nucleosides	75-85	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	18-21
18487070-7	2008	EFdA appears to be primarily phosphorylated by the cellular 2"-deoxycytidine kinase (dCK) because: (a) the antiviral activity of EFdA was reduced by the addition of dC, which competes nucleosides phosphorylated by the dCK pathway, (b) the antiviral activity of EFdA was significantly reduced in dCK-deficient HT-1080/Ara-Cr cells, but restored after dCK transduction.	Nucleosides	184-195	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	85-88
19544670-0	2008	Inhibition of Nm23H2 gene product (NDPK-B) by angiostatin, polyphenols and nucleoside analogs.	Nucleosides	75-85	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	14-20
19544670-0	2008	Inhibition of Nm23H2 gene product (NDPK-B) by angiostatin, polyphenols and nucleoside analogs.	Nucleosides	75-85	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	35-41
18406377-4	2008	TLR7-9 recognize single-stranded RNA, nucleoside analogs and single-stranded CpG-DNA, respectively, and their activation initiates the immune response against viruses and bacteria.	Nucleosides	38-48	toll like receptor 7	Homo sapiens	0-6
17872922-7	2008	These biochemical and transgenic data suggest that AtENT6, an Arabidopsis ENT, could also participate in cytokinin nucleoside transport with a preference for iP riboside in vascular tissue.	Nucleosides	115-125	equilibrative nucleoside transporter 6	Arabidopsis thaliana	51-57
18776499-6	2008	As part of the SAR series, we also prepared nucleoside analogs 7 (S-constrained ethyl, S-cEt) and 8 (R-constrained Ethyl, R-cEt) where the methoxymethyl group in the cMOE nucleosides was replaced with a methyl substituent.	Nucleosides	44-54	sarcosine dehydrogenase	Homo sapiens	15-18
18779872-7	2008	A further opportunity is offered by promoting strategies that downregulate CXCR4 pathways: CXCR4 expression in the tumor microenvironment is modulated by factors such as hypoxia, nucleosides, and eicosanoids.	Nucleosides	179-190	C-X-C motif chemokine receptor 4	Homo sapiens	75-80
18779872-7	2008	A further opportunity is offered by promoting strategies that downregulate CXCR4 pathways: CXCR4 expression in the tumor microenvironment is modulated by factors such as hypoxia, nucleosides, and eicosanoids.	Nucleosides	179-190	C-X-C motif chemokine receptor 4	Homo sapiens	91-96
18084067-2	2007	The structures of dCK alone and the dead-end complex of dCK with substrate nucleoside and product ADP or UDP have previously been reported; however, there is currently no structure available for a substrate or product complex.	Nucleosides	75-85	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	56-59
17855478-1	2007	Deoxycytidine kinase (DCK) is a rate-limiting enzyme in the activation of nucleoside analogs such as cytarabine (ara-C), gemcitabine, clofarabine, and others.	Nucleosides	74-84	deoxycytidine kinase	Homo sapiens	0-20
17662475-5	2007	The replicon cells were subjected to treatment with several antiviral compounds and inhibition of the replicon was observed in treatment with known nucleoside analog inhibitors of NS5 such as 2"-C-methyladenosine (EC(50)=2.42 +/- 0.59 microM), or ribavirin (EC(50)=6.77 +/- 1.33 microM), mycophenolic acid (EC(50)=1.31 +/- 0.27 microM) and siRNA against NS3.	Nucleosides	148-158	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	180-183
17982658-3	2007	We found that the PC9/f14 subpopulation, which we previously reported to be resistant to gefitinib, was also resistant to gemcitabine (2",2"-difluoro-2"-deoxy-cytidine), a nucleoside analogue.	Nucleosides	172-182	proprotein convertase subtilisin/kexin type 9	Homo sapiens	18-21
17855478-1	2007	Deoxycytidine kinase (DCK) is a rate-limiting enzyme in the activation of nucleoside analogs such as cytarabine (ara-C), gemcitabine, clofarabine, and others.	Nucleosides	74-84	deoxycytidine kinase	Homo sapiens	22-25
18041859-2	2007	The base-electrode interaction is modeled using a nucleo-base-functionalized STM probe that is pulled away from a nucleoside monolayer.	Nucleosides	114-124	sulfotransferase family 1A member 3	Homo sapiens	77-80
18045284-1	2007	BACKGROUND: Interferon (IFN)-alpha and lamivudine (LAM), a nucleoside analog, are frequently used drugs for the treatment of chronic hepatitis B (CHB), and their combined therapy has been shown to be effective.	Nucleosides	59-69	interferon alpha 1	Homo sapiens	12-34
17855655-7	2007	In summary, these findings suggest that mitochondrial targeting of Dm-dNK facilitates nucleoside and nucleoside analog phosphorylation and could be used as a strategy to enhance the efficacy of nucleoside analog phosphorylation and concomitantly their cytostatic potential.	Nucleosides	86-96	deoxyribonucleoside kinase	Drosophila melanogaster	67-73
17855655-7	2007	In summary, these findings suggest that mitochondrial targeting of Dm-dNK facilitates nucleoside and nucleoside analog phosphorylation and could be used as a strategy to enhance the efficacy of nucleoside analog phosphorylation and concomitantly their cytostatic potential.	Nucleosides	101-111	deoxyribonucleoside kinase	Drosophila melanogaster	67-73
17855655-7	2007	In summary, these findings suggest that mitochondrial targeting of Dm-dNK facilitates nucleoside and nucleoside analog phosphorylation and could be used as a strategy to enhance the efficacy of nucleoside analog phosphorylation and concomitantly their cytostatic potential.	Nucleosides	101-111	deoxyribonucleoside kinase	Drosophila melanogaster	67-73
17958644-3	2007	Better results have recently been reported with pegylated IFN both in IFN-naive and in previous nonresponders to standard IFN, suggesting the use of pegylated IFN as a first-line therapy in chronic hepatitis D. Nucleoside analogues that inhibit hepatitis B virus (HBV) are ineffective against HDV and combination therapy with lamivudine or ribavirin has not shown significant advantages over monotherapy with either standard or pegylated IFN.	Nucleosides	211-221	interferon alpha 1	Homo sapiens	58-61
17581598-3	2007	We used directed evolution to create Dm-dNK mutants with increased specificity for several nucleoside analogs (NAs) used as anticancer or antiviral drugs.	Nucleosides	91-101	deoxyribonucleoside kinase	Drosophila melanogaster	37-43
17881823-12	2007	On the basis of the surface properties, a docking model of P. horikoshii TYW1, the tRNA, the FeS clusters and the AdoMet molecule was constructed, with the nucleoside at position 37 of tRNA flipped out from the canonical tRNA structure.	Nucleosides	156-166	putative tRNA 4-demethylwyosine synthase	Saccharomyces cerevisiae S288C	73-77
17728871-8	2007	The nucleosides 3a-d exist predominantly in the keto (lactam) form with K(TAUT) (keto/enol) values of 400-1200 compared to 10(3)-10(4) for pyrrolo[2,3-d]pyrimidine isoguanosine derivatives 4a-c and 10 for isoguanosine itself, which will reduce RNA mispairing with U.	Nucleosides	4-15	solute carrier family 6 member 6	Homo sapiens	74-78
17597075-3	2007	Whereas it is not clear if Mycobacterium tuberculosis (Mtb) ADK is essential, it has been shown that the enzyme can selectively phosphorylate nucleoside analogs to produce products toxic to the cell.	Nucleosides	142-152	adenosine kinase	Homo sapiens	60-63
17914902-2	2007	Crystal structures of human Nrk1 bound to nucleoside and nucleotide substrates and products revealed an enzyme structurally similar to Rossmann fold metabolite kinases and allowed the identification of active site residues, which were shown to be essential for human Nrk1 and Nrk2 activity in vivo.	Nucleosides	42-52	nicotinamide riboside kinase 1	Homo sapiens	28-32
17914902-2	2007	Crystal structures of human Nrk1 bound to nucleoside and nucleotide substrates and products revealed an enzyme structurally similar to Rossmann fold metabolite kinases and allowed the identification of active site residues, which were shown to be essential for human Nrk1 and Nrk2 activity in vivo.	Nucleosides	42-52	nicotinamide riboside kinase 1	Homo sapiens	267-271
17914902-2	2007	Crystal structures of human Nrk1 bound to nucleoside and nucleotide substrates and products revealed an enzyme structurally similar to Rossmann fold metabolite kinases and allowed the identification of active site residues, which were shown to be essential for human Nrk1 and Nrk2 activity in vivo.	Nucleosides	42-52	nicotinamide riboside kinase 2	Homo sapiens	276-280
17785418-10	2007	We propose a dual role for RNA substrates in TUTase-catalyzed reactions: contribution to selective incorporation of the cognate nucleoside and shaping of the catalytic metal binding site.	Nucleosides	128-138	terminal uridylyl transferase 1, U6 snRNA-specific	Homo sapiens	45-51
17955979-2	2007	Milk contains a complex mixture of nucleotides, nucleosides, and nucleobases, and because of the reported differences in their relative levels in bovine and human milks, pediatric formulas are increasingly supplemented with nucleotides.	Nucleosides	48-59	Weaning weight-maternal milk	Bos taurus	0-4
17655217-2	2007	A comprehensive conformational analysis of isolated 2"-beta-deoxy-thymidine (T), canonical DNA nucleoside, has been performed by means of ab initio calculations at the MP2/6-311++G(d,p)//DFT B3LYP/6-31G(d,p) level of theory.	Nucleosides	95-105	tryptase pseudogene 1	Homo sapiens	168-171
17700367-1	2007	The human concentrative nucleoside transporter (hCNT2), also known as SLC28A2, plays an important role in the cellular uptake across intestinal membrane of some naturally occurring nucleosides and nucleoside analogs.	Nucleosides	181-192	solute carrier family 28 member 2	Homo sapiens	48-53
17700367-1	2007	The human concentrative nucleoside transporter (hCNT2), also known as SLC28A2, plays an important role in the cellular uptake across intestinal membrane of some naturally occurring nucleosides and nucleoside analogs.	Nucleosides	181-192	solute carrier family 28 member 2	Homo sapiens	70-77
17700367-1	2007	The human concentrative nucleoside transporter (hCNT2), also known as SLC28A2, plays an important role in the cellular uptake across intestinal membrane of some naturally occurring nucleosides and nucleoside analogs.	Nucleosides	24-34	solute carrier family 28 member 2	Homo sapiens	48-53
17700367-1	2007	The human concentrative nucleoside transporter (hCNT2), also known as SLC28A2, plays an important role in the cellular uptake across intestinal membrane of some naturally occurring nucleosides and nucleoside analogs.	Nucleosides	24-34	solute carrier family 28 member 2	Homo sapiens	70-77
17350163-1	2007	Deoxycytidine kinase (dCK) activates several antileukaemic nucleoside analogues.	Nucleosides	59-69	deoxycytidine kinase	Homo sapiens	0-20
17350163-1	2007	Deoxycytidine kinase (dCK) activates several antileukaemic nucleoside analogues.	Nucleosides	59-69	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
17350163-5	2007	These results suggest that activation of dCK via phosphorylation of Ser-74 might constitute a new therapeutic strategy to enhance activation and efficacy of nucleoside analogues.	Nucleosides	157-167	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	41-44
17412768-0	2007	Role of CNT3 in the transepithelial flux of nucleosides and nucleoside-derived drugs.	Nucleosides	44-55	solute carrier family 28 member 3	Homo sapiens	8-12
17412768-0	2007	Role of CNT3 in the transepithelial flux of nucleosides and nucleoside-derived drugs.	Nucleosides	44-54	solute carrier family 28 member 3	Homo sapiens	8-12
17412768-1	2007	We examined the role of the concentrative nucleoside transporter CNT3 in the establishment of a transepithelial flux of natural nucleosides and their pharmacologically active derivatives in renal epithelial cell lines.	Nucleosides	128-139	solute carrier family 28 member 3	Homo sapiens	65-69
17412768-3	2007	hCNT3 was also identified in human kidney and its role in the transport of nucleosides was tested.	Nucleosides	75-86	solute carrier family 28 member 3	Homo sapiens	0-5
17412768-5	2007	In these cells, hCNT3 was inserted into the apical membrane, thus generating, as for PCT cells, a transepithelial flux of both nucleosides and nucleoside-derived drugs.	Nucleosides	127-138	solute carrier family 28 member 3	Homo sapiens	16-21
17412768-5	2007	In these cells, hCNT3 was inserted into the apical membrane, thus generating, as for PCT cells, a transepithelial flux of both nucleosides and nucleoside-derived drugs.	Nucleosides	127-137	solute carrier family 28 member 3	Homo sapiens	16-21
17412768-8	2007	However release to the opposite compartment was CNT3 dependent, not only in terms of absolute flux (much higher when an apical CNT3 transporter was active) but also regarding metabolic transformations of the apically absorbed nucleosides.	Nucleosides	226-237	solute carrier family 28 member 3	Homo sapiens	48-52
17412768-8	2007	However release to the opposite compartment was CNT3 dependent, not only in terms of absolute flux (much higher when an apical CNT3 transporter was active) but also regarding metabolic transformations of the apically absorbed nucleosides.	Nucleosides	226-237	solute carrier family 28 member 3	Homo sapiens	127-131
17412768-9	2007	These results underline a critical role of CNT3 in the renal reabsorption of nucleosides and their derivatives as well as in their intracellular metabolism.	Nucleosides	77-88	solute carrier family 28 member 3	Homo sapiens	43-47
17409283-8	2007	The presence of 1) transcripts for hENT1/2 and hCNT1/2/3 and the hENT1 and hCNT3 proteins in human kidneys and 2) hENT1, hENT2, and hCNT3 activities in cultured proximal tubule cells suggest involvement of hENT1, hCNT3, and possibly also hENT2 in renal handling of nucleosides and nucleoside drugs.	Nucleosides	265-276	solute carrier family 28 member 3	Homo sapiens	132-137
17543337-4	2007	These results demonstrate the potential of non-homologous recombination within the dNK family for creating enzymes with new and improved activities towards nucleoside analogs.	Nucleosides	156-166	deoxyribonucleoside kinase	Drosophila melanogaster	83-86
17409283-8	2007	The presence of 1) transcripts for hENT1/2 and hCNT1/2/3 and the hENT1 and hCNT3 proteins in human kidneys and 2) hENT1, hENT2, and hCNT3 activities in cultured proximal tubule cells suggest involvement of hENT1, hCNT3, and possibly also hENT2 in renal handling of nucleosides and nucleoside drugs.	Nucleosides	265-276	solute carrier family 28 member 3	Homo sapiens	132-137
17409283-8	2007	The presence of 1) transcripts for hENT1/2 and hCNT1/2/3 and the hENT1 and hCNT3 proteins in human kidneys and 2) hENT1, hENT2, and hCNT3 activities in cultured proximal tubule cells suggest involvement of hENT1, hCNT3, and possibly also hENT2 in renal handling of nucleosides and nucleoside drugs.	Nucleosides	265-275	solute carrier family 28 member 3	Homo sapiens	132-137
17409283-8	2007	The presence of 1) transcripts for hENT1/2 and hCNT1/2/3 and the hENT1 and hCNT3 proteins in human kidneys and 2) hENT1, hENT2, and hCNT3 activities in cultured proximal tubule cells suggest involvement of hENT1, hCNT3, and possibly also hENT2 in renal handling of nucleosides and nucleoside drugs.	Nucleosides	265-275	solute carrier family 28 member 3	Homo sapiens	132-137
17205396-0	2007	Identification and biochemical studies on novel non-nucleoside inhibitors of the enzyme adenosine kinase.	Nucleosides	52-62	adenosine kinase	Homo sapiens	88-104
17371872-0	2007	The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation.	Nucleosides	4-14	protein kinase C delta	Homo sapiens	120-141
17371872-0	2007	The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation.	Nucleosides	4-14	mitogen-activated protein kinase 8	Homo sapiens	146-149
17473446-0	2007	Mouse equilibrative nucleoside transporter 2 (mENT2) transports nucleosides and purine nucleobases differing from human and rat ENT2.	Nucleosides	64-75	equilibrative nucleoside transporter 2	Rattus norvegicus	6-44
17473446-0	2007	Mouse equilibrative nucleoside transporter 2 (mENT2) transports nucleosides and purine nucleobases differing from human and rat ENT2.	Nucleosides	64-75	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	46-51
17473446-0	2007	Mouse equilibrative nucleoside transporter 2 (mENT2) transports nucleosides and purine nucleobases differing from human and rat ENT2.	Nucleosides	64-75	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	47-51
17473446-2	2007	Human and rat equilibrative nucleoside transporter 2 (hENT2 and rENT2, respectively) was previously reported to have the dual ability of transporting both nucleosides and nucleobases.	Nucleosides	155-166	equilibrative nucleoside transporter 2	Rattus norvegicus	14-52
17473446-2	2007	Human and rat equilibrative nucleoside transporter 2 (hENT2 and rENT2, respectively) was previously reported to have the dual ability of transporting both nucleosides and nucleobases.	Nucleosides	155-166	solute carrier family 29 member 2	Homo sapiens	54-59
17473446-3	2007	In the present study, we characterized the transport of a variety of nucleosides and nucleobases via recombinant mouse ENT2 (mENT2).	Nucleosides	69-80	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	119-123
17473446-3	2007	In the present study, we characterized the transport of a variety of nucleosides and nucleobases via recombinant mouse ENT2 (mENT2).	Nucleosides	69-80	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	125-130
17473446-4	2007	Cloned mENT2 mediated the uptake of nucleosides and purine nucleobases, but not pyrimidine nucleobases.	Nucleosides	36-47	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	7-12
17473446-5	2007	The mENT2-mediated uptake of adenosine was significantly inhibited by nucleosides and nucleobases, irrespective of purine and pyrimidine.	Nucleosides	70-81	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	4-9
17473446-6	2007	The K(m) values for the uptake of nucleosides and purine nucleobases mediated by mENT2 varied between 1.24 and 16.3 microM, and the transport clearances of adenosine and hypoxanthine via the transporter were greater than those of other substrates.	Nucleosides	34-45	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	81-86
17358027-7	2007	Elevations in GPA N/N variants generally persisted through 1 year of age in nucleoside analog-exposed children.	Nucleosides	76-86	glycophorin A (MNS blood group)	Homo sapiens	14-17
17358029-0	2007	Relative mutagenic potencies of several nucleoside analogs, alone or in drug pairs, at the HPRT and TK loci of human TK6 lymphoblastoid cells.	Nucleosides	40-50	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	91-95
17542617-1	2007	His272 (7.43) in the seventh transmembrane domain (TM7) of the human A3 adenosine receptor (AR) interacts with the 3" position of nucleosides, based on selective affinity enhancement at a H272E mutant A3 AR (neoceptor) of 3"-ureido, but not 3"-OH, adenosine analogues.	Nucleosides	130-141	adenosine A3 receptor	Homo sapiens	201-206
17438061-2	2007	To understand the low susceptibility of BV to the acyclonucleosides, we have cloned, expressed, and characterized the BV thymidine kinase (TK), an enzyme that is expected to "activate" nucleoside analogs.	Nucleosides	56-66	thymidine kinase	Macacine alphaherpesvirus 1	121-137
17357160-0	2007	Human DEAD-box ATPase DDX3 shows a relaxed nucleoside substrate specificity.	Nucleosides	43-53	DEAD-box helicase 3 X-linked	Homo sapiens	22-26
17331718-2	2007	The lack of antiviral activity of these nucleosides was associated with a poor affinity for adenosine kinase, which prompted us to synthesize several of their 5"-monophosphate prodrugs.	Nucleosides	40-51	adenosine kinase	Homo sapiens	92-108
17324575-1	2007	Selective and effective TK2 inhibitors can be obtained by introduction of bulky lipophilic chains (acyl or alkyl entities) at the 2" position of araT and BVaraU, nucleoside analogues naturally endowed with a low TK2 affinity.	Nucleosides	162-172	thymidine kinase 2	Homo sapiens	24-27
17324575-3	2007	BVaraU nucleoside analogues, modified on the 2"-O-acyl chain with a terminal N-Boc amino-group, conserved or increased the inhibitory activity against TK2 (7l and 7m IC(50): 6.4 and 3.8 microM, respectively).	Nucleosides	7-17	thymidine kinase 2	Homo sapiens	151-154
17393513-7	2007	Several oral nucleoside analogues with activity against HBV have been shown to be effective in suppressing viral levels and improving biochemical and histological features of disease in a high proportion of patients with and without HBeAg, at least in the short term.	Nucleosides	13-23	capsid protein;pre-capsid protein	Hepatitis B virus	233-238
18404431-6	2007	Pericellular nucleotide/nucleoside fluxes caused by dendritic cell expressed CD39 are also involved in the recruitment, activation and polarization of naive T cells.	Nucleosides	24-34	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	77-81
17088032-3	2007	Equilibrative nucleoside transporter 2 (ENT2) was previously reported to have the dual ability of transporting both nucleosides and nucleobases.	Nucleosides	116-127	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	40-44
17253988-8	2007	Furthermore, we showed that this mutation is indeed responsible for the observed alterations in nucleoside transport in the fur1-1 line, because the introduction of this mutation in AtENT3 promoted fluorouridine resistance in yeast cells expressing this mutated protein.	Nucleosides	96-106	Major facilitator superfamily protein	Arabidopsis thaliana	182-188
17253988-9	2007	The biochemical characterization of AtENT3 expressed in Xenopus oocytes identified a proton-coupled concentrative mode of nucleoside transport, although this carrier possesses structural features characteristic for equilibrative nucleoside carriers.	Nucleosides	122-132	Major facilitator superfamily protein	Arabidopsis thaliana	36-42
17253988-9	2007	The biochemical characterization of AtENT3 expressed in Xenopus oocytes identified a proton-coupled concentrative mode of nucleoside transport, although this carrier possesses structural features characteristic for equilibrative nucleoside carriers.	Nucleosides	229-239	Major facilitator superfamily protein	Arabidopsis thaliana	36-42
17266931-1	2007	Human thymidine kinase 2 (TK2) is critical for the nucleotide salvage pathway and phosphorylation of nucleoside analog prodrugs in vivo; however, it remains poorly studied because of difficulties in expressing it heterologously.	Nucleosides	101-111	thymidine kinase 2	Homo sapiens	6-24
17266931-1	2007	Human thymidine kinase 2 (TK2) is critical for the nucleotide salvage pathway and phosphorylation of nucleoside analog prodrugs in vivo; however, it remains poorly studied because of difficulties in expressing it heterologously.	Nucleosides	101-111	thymidine kinase 2	Homo sapiens	26-29
17266931-5	2007	These mutations improve the K(M) for thymidine, increasing the catalytic activity of L78F/L116M-TK2 4.4-fold, yet leaving the activity for deoxycytidine or the purine nucleosides unchanged.	Nucleosides	167-178	thymidine kinase 2	Homo sapiens	96-99
16868766-8	2007	Similar to the case for other MRPs that possess only two membrane spanning domains (MRP4 and MRP5), MRP8 is a cyclic nucleotide efflux pump that is able to confer resistance to nucleoside-based agents, such as PMEA and 5FU.	Nucleosides	177-187	ATP binding cassette subfamily C member 4	Homo sapiens	84-88
17121826-4	2007	By constructing chimeras between human PMAT and ENT1, we showed that a chimera consisting of transmembrane domains (TM) 1-6 of PMAT and TM7-11 of hENT1 behaved like PMAT, transporting 1-methyl-4-phenylpyridinium (MPP+, an organic cation) but not uridine (a nucleoside), suggesting that TM1-6 contains critical domains responsible for substrate recognition.	Nucleosides	257-267	solute carrier family 29 member 4	Homo sapiens	39-43
17121826-4	2007	By constructing chimeras between human PMAT and ENT1, we showed that a chimera consisting of transmembrane domains (TM) 1-6 of PMAT and TM7-11 of hENT1 behaved like PMAT, transporting 1-methyl-4-phenylpyridinium (MPP+, an organic cation) but not uridine (a nucleoside), suggesting that TM1-6 contains critical domains responsible for substrate recognition.	Nucleosides	257-267	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	48-52
17121826-4	2007	By constructing chimeras between human PMAT and ENT1, we showed that a chimera consisting of transmembrane domains (TM) 1-6 of PMAT and TM7-11 of hENT1 behaved like PMAT, transporting 1-methyl-4-phenylpyridinium (MPP+, an organic cation) but not uridine (a nucleoside), suggesting that TM1-6 contains critical domains responsible for substrate recognition.	Nucleosides	257-267	solute carrier family 29 member 4	Homo sapiens	127-131
17121826-4	2007	By constructing chimeras between human PMAT and ENT1, we showed that a chimera consisting of transmembrane domains (TM) 1-6 of PMAT and TM7-11 of hENT1 behaved like PMAT, transporting 1-methyl-4-phenylpyridinium (MPP+, an organic cation) but not uridine (a nucleoside), suggesting that TM1-6 contains critical domains responsible for substrate recognition.	Nucleosides	257-267	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	146-151
17121826-4	2007	By constructing chimeras between human PMAT and ENT1, we showed that a chimera consisting of transmembrane domains (TM) 1-6 of PMAT and TM7-11 of hENT1 behaved like PMAT, transporting 1-methyl-4-phenylpyridinium (MPP+, an organic cation) but not uridine (a nucleoside), suggesting that TM1-6 contains critical domains responsible for substrate recognition.	Nucleosides	257-267	solute carrier family 29 member 4	Homo sapiens	127-131
16586096-8	2007	Transfected cells containing high concentrations of MRP4 and 5 are moderately resistant to base, nucleoside, and nucleotide analogs.	Nucleosides	97-107	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	52-62
16868766-8	2007	Similar to the case for other MRPs that possess only two membrane spanning domains (MRP4 and MRP5), MRP8 is a cyclic nucleotide efflux pump that is able to confer resistance to nucleoside-based agents, such as PMEA and 5FU.	Nucleosides	177-187	ATP binding cassette subfamily C member 5	Homo sapiens	93-97
16868766-8	2007	Similar to the case for other MRPs that possess only two membrane spanning domains (MRP4 and MRP5), MRP8 is a cyclic nucleotide efflux pump that is able to confer resistance to nucleoside-based agents, such as PMEA and 5FU.	Nucleosides	177-187	ATP binding cassette subfamily C member 11	Homo sapiens	100-104
17210706-8	2007	These findings indicate that Mrp4 is an endogenous resistance factor, and that the pump may be a component of the blood-brain barrier for nucleoside-based analogues.	Nucleosides	138-148	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	29-33
17693958-0	2007	Synthesis of functionalised nucleosides for incorporation into nucleic acid-based serine protease mimics.	Nucleosides	28-39	coagulation factor II, thrombin	Homo sapiens	82-97
17693958-2	2007	These nucleosides can be incorporated into an oligonucleotide duplex, thus generating a novel type of serine protease mimic.	Nucleosides	6-17	coagulation factor II, thrombin	Homo sapiens	102-117
17713153-5	2007	More promising data were obtained when AZT, 3TC and ABC were intensified with tenofovir (TDF), resulting in a quadruple nucleoside therapy.	Nucleosides	120-130	sex determining region Y	Homo sapiens	89-92
17453413-8	2007	The Na(+)/nucleoside stoichiometry of hCNT2, as determined from both Hill coefficients and direct charge/flux measurements, was 1:1.	Nucleosides	10-20	solute carrier family 28 member 2	Homo sapiens	38-43
16581133-4	2007	The biochemical properties of polymerases-theta and -eta indicate that their DNA synthetic activities are potentially susceptible to inhibition by nucleoside analogues, so it is feasible that nucleoside analogues reduce the accumulation of dC/dG- and dA/dT-targeted hypermutations in vivo.	Nucleosides	147-157	endothelin receptor type A	Homo sapiens	44-47
16581133-4	2007	The biochemical properties of polymerases-theta and -eta indicate that their DNA synthetic activities are potentially susceptible to inhibition by nucleoside analogues, so it is feasible that nucleoside analogues reduce the accumulation of dC/dG- and dA/dT-targeted hypermutations in vivo.	Nucleosides	192-202	endothelin receptor type A	Homo sapiens	44-47
17504141-6	2007	The linkers have been attached at the C-5", C-5 or N-3 positions of the nucleoside, and in some of the substrates synthesized, a synergistic anti-HIV activity has been observed.	Nucleosides	72-82	complement C5	Homo sapiens	38-41
17504141-6	2007	The linkers have been attached at the C-5", C-5 or N-3 positions of the nucleoside, and in some of the substrates synthesized, a synergistic anti-HIV activity has been observed.	Nucleosides	72-82	complement C5	Homo sapiens	44-47
17158155-6	2007	The capability of dCK to phosphorylate both D- and L-nucleosides and nucleoside analogs derives from structural properties of both the enzyme and the substrates themselves.	Nucleosides	53-63	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	18-21
18066871-1	2007	A new group of terminal deoxynucleotidyltransferase (TDT) substrates, namely, non-nucleoside triphosphates (NNTP) bearing 5-substituted 2,4-dinitrophenyl fragments instead of nucleoside residues was synthesized.	Nucleosides	82-92	DNA nucleotidylexotransferase	Homo sapiens	15-51
18029664-6	2007	Structural studies of the free nucleoside revealed that both bases are preferred syn conformation, thus mimicking the conformation of the oxopurine nucleosides.	Nucleosides	31-41	synemin	Homo sapiens	81-84
18029682-0	2007	Influence of nucleoside analogue treatment on telomere length and TRF2 amount in human HL60 cells.	Nucleosides	13-23	telomeric repeat binding factor 2	Homo sapiens	66-70
18029682-5	2007	The effects of nucleoside analogues on TRF2 suggest that it is not telomere length per se, but rather the presence or absence of a protective telomere state, which determines whether senescence ensues.	Nucleosides	15-25	telomeric repeat binding factor 2	Homo sapiens	39-43
18029567-1	2007	Our effort in designing base-discriminating fluorescence nucleosides (BDF), leads us to develop dual-labeled oligonucleotide probe in which the BDF nucleoside, (Py)U/(2-Ant)U act as the donor separated by a defined base pair distance from the acceptor, fluorescein, attached to 5"-end of the probe.	Nucleosides	57-68	solute carrier family 25 member 6	Homo sapiens	169-172
18029597-5	2007	Here we describe the use of synthetic nucleoside analogs incorporated into RNA editing substrates via the protected phosphoramidites to define aspects of the editing reaction mechanism and to carry out mechanism-based trapping of ADAR-RNA complexes.	Nucleosides	38-48	adenosine deaminase RNA specific	Homo sapiens	230-234
18066871-1	2007	A new group of terminal deoxynucleotidyltransferase (TDT) substrates, namely, non-nucleoside triphosphates (NNTP) bearing 5-substituted 2,4-dinitrophenyl fragments instead of nucleoside residues was synthesized.	Nucleosides	82-92	DNA nucleotidylexotransferase	Homo sapiens	53-56
17209766-9	2006	Treatment with nucleoside analogues was significantly associated with macrocytosis and low haptoglobin.	Nucleosides	15-25	haptoglobin	Homo sapiens	91-102
18058533-4	2007	Moreover, the effects of nucleoside analogues on PTEN promoter methylation suggest distinct mechanism of regulation of the epigenetic DNA modification in low-invasive compared to highly invasive breast cancer cells.	Nucleosides	25-35	phosphatase and tensin homolog	Homo sapiens	49-53
16837649-1	2006	The Na(+)-dependent nucleoside transporter 2 (CNT2) mediates active transport of purine nucleosides and uridine as well as therapeutic nucleoside analogs.	Nucleosides	88-99	solute carrier family 28 member 2	Rattus norvegicus	46-50
16837649-1	2006	The Na(+)-dependent nucleoside transporter 2 (CNT2) mediates active transport of purine nucleosides and uridine as well as therapeutic nucleoside analogs.	Nucleosides	20-30	solute carrier family 28 member 2	Rattus norvegicus	46-50
16965766-0	2006	Human equilibrative nucleoside transporter-1 (hENT1) is required for the transcriptomic response of the nucleoside-derived drug 5"-DFUR in breast cancer MCF7 cells.	Nucleosides	20-30	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-51
17149867-8	2006	Thus, N(6)-substituted 2-(1,2,3-triazolyl)adenosine analogues constitute a novel class of highly potent and selective nucleoside-based A(3)AR antagonists, partial agonists, and agonists.	Nucleosides	118-128	adenosine A3 receptor	Homo sapiens	135-141
16936229-5	2006	1-beta-D-Arabinofuranosylcytosine (ara-C), a chemotherapy agent often used in combination with MTX, is a nucleoside analog whose incorporation into chromosome requires prior phosphorylation by dCK.	Nucleosides	105-115	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	193-196
17013559-6	2006	The evidence that CNT2 is not a target of multifunctional cytokines involved in hepatocyte proliferation, but instead, of a cytokine that plays major roles in differentiation and apoptosis, further supports the view that the main physiological role of this transporter protein is not nucleoside salvage.	Nucleosides	284-294	solute carrier family 28 member 2	Rattus norvegicus	18-22
17215872-5	2006	The well characterized hENTs (hENT1 and hENT2) are bidirectional facilitative diffusion transporters in plasma membranes; hENT3 and hENT4 are much less well known, although hENT3, found in lysosomal membranes, transports nucleosides and is pH dependent, whereas hENT4-PMAT is a H+-adenosine cotransporter as well as a monoamine-organic cation transporter.	Nucleosides	221-232	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	30-35
17215872-5	2006	The well characterized hENTs (hENT1 and hENT2) are bidirectional facilitative diffusion transporters in plasma membranes; hENT3 and hENT4 are much less well known, although hENT3, found in lysosomal membranes, transports nucleosides and is pH dependent, whereas hENT4-PMAT is a H+-adenosine cotransporter as well as a monoamine-organic cation transporter.	Nucleosides	221-232	solute carrier family 29 member 2	Homo sapiens	40-45
17215872-5	2006	The well characterized hENTs (hENT1 and hENT2) are bidirectional facilitative diffusion transporters in plasma membranes; hENT3 and hENT4 are much less well known, although hENT3, found in lysosomal membranes, transports nucleosides and is pH dependent, whereas hENT4-PMAT is a H+-adenosine cotransporter as well as a monoamine-organic cation transporter.	Nucleosides	221-232	solute carrier family 29 member 3	Homo sapiens	122-127
17215872-5	2006	The well characterized hENTs (hENT1 and hENT2) are bidirectional facilitative diffusion transporters in plasma membranes; hENT3 and hENT4 are much less well known, although hENT3, found in lysosomal membranes, transports nucleosides and is pH dependent, whereas hENT4-PMAT is a H+-adenosine cotransporter as well as a monoamine-organic cation transporter.	Nucleosides	221-232	solute carrier family 29 member 4	Homo sapiens	132-137
17215872-5	2006	The well characterized hENTs (hENT1 and hENT2) are bidirectional facilitative diffusion transporters in plasma membranes; hENT3 and hENT4 are much less well known, although hENT3, found in lysosomal membranes, transports nucleosides and is pH dependent, whereas hENT4-PMAT is a H+-adenosine cotransporter as well as a monoamine-organic cation transporter.	Nucleosides	221-232	solute carrier family 29 member 3	Homo sapiens	173-178
17215872-7	2006	In renal epithelial cells, hCNT1, hCNT2, and hCNT3 at apical membranes, and hENT1 and hENT2 at basolateral membranes, apparently work in concert to mediate reabsorption of nucleosides from lumen to blood, driven by Na+ gradients.	Nucleosides	172-183	solute carrier family 28 member 1	Homo sapiens	27-32
17215872-7	2006	In renal epithelial cells, hCNT1, hCNT2, and hCNT3 at apical membranes, and hENT1 and hENT2 at basolateral membranes, apparently work in concert to mediate reabsorption of nucleosides from lumen to blood, driven by Na+ gradients.	Nucleosides	172-183	solute carrier family 28 member 2	Homo sapiens	34-39
17215872-7	2006	In renal epithelial cells, hCNT1, hCNT2, and hCNT3 at apical membranes, and hENT1 and hENT2 at basolateral membranes, apparently work in concert to mediate reabsorption of nucleosides from lumen to blood, driven by Na+ gradients.	Nucleosides	172-183	solute carrier family 28 member 3	Homo sapiens	45-50
17215872-7	2006	In renal epithelial cells, hCNT1, hCNT2, and hCNT3 at apical membranes, and hENT1 and hENT2 at basolateral membranes, apparently work in concert to mediate reabsorption of nucleosides from lumen to blood, driven by Na+ gradients.	Nucleosides	172-183	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	76-81
17215872-7	2006	In renal epithelial cells, hCNT1, hCNT2, and hCNT3 at apical membranes, and hENT1 and hENT2 at basolateral membranes, apparently work in concert to mediate reabsorption of nucleosides from lumen to blood, driven by Na+ gradients.	Nucleosides	172-183	solute carrier family 29 member 2	Homo sapiens	86-91
17215872-9	2006	Mounting evidence suggests that hENT1 may have a presence at both apical and basolateral membranes of renal epithelia, and thus may participate in both selective secretory and reabsorptive fluxes of nucleosides.	Nucleosides	199-210	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	32-37
18404470-1	2006	Cytosolic 5" nucleotidase II (cN-II) catalyses both the hydrolysis of a number of nucleoside monophosphates (e.g., IMP + H2O--> inosine + Pi), and the phosphate transfer from a nucleoside monophosphate donor to the 5" position of a nucleoside acceptor (e.g., IMP + guanosine --> inosine + GMP).	Nucleosides	82-92	5'-nucleotidase, cytosolic II	Homo sapiens	0-28
18404470-1	2006	Cytosolic 5" nucleotidase II (cN-II) catalyses both the hydrolysis of a number of nucleoside monophosphates (e.g., IMP + H2O--> inosine + Pi), and the phosphate transfer from a nucleoside monophosphate donor to the 5" position of a nucleoside acceptor (e.g., IMP + guanosine --> inosine + GMP).	Nucleosides	82-92	5'-nucleotidase, cytosolic II	Homo sapiens	30-35
16803458-1	2006	HTP (human thymidine phosphorylase), also known as PD-ECGF (platelet-derived endothelial cell growth factor) or gliostatin, has an important role in nucleoside metabolism.	Nucleosides	149-159	thymidine phosphorylase	Homo sapiens	51-58
16803458-1	2006	HTP (human thymidine phosphorylase), also known as PD-ECGF (platelet-derived endothelial cell growth factor) or gliostatin, has an important role in nucleoside metabolism.	Nucleosides	149-159	thymidine phosphorylase	Homo sapiens	60-107
16803458-1	2006	HTP (human thymidine phosphorylase), also known as PD-ECGF (platelet-derived endothelial cell growth factor) or gliostatin, has an important role in nucleoside metabolism.	Nucleosides	149-159	thymidine phosphorylase	Homo sapiens	112-122
16840788-0	2006	Molecular determinants of specificity for synthetic nucleoside analogs in the concentrative nucleoside transporter, CNT2.	Nucleosides	52-62	solute carrier family 28 member 2	Homo sapiens	116-120
16463058-9	2006	CONCLUSIONS: These results show that genetic modifications in non-hematological malignant cells may be associated with resistance to gemcitabine, and that the gene transfer of non-human genes can be used for the reversion of nucleoside analogue resistance due to dCK deficiency.	Nucleosides	225-235	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	263-266
16981822-4	2006	Now an Associate Professor in Medicine at Harvard University, Dr Robson is conducting research dealing with the vascular biology of transplantation and specifically focussing on how endothelial and immune cell purinergic signalling is modulated by ecto-nucleotidases of the CD39 family (ecto-enzymes that hydrolyse extracellular nucleotides to generate nucleosides).	Nucleosides	353-364	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	274-278
16964310-1	2006	Defects in purine nucleoside phosphorylase (PNP) enzyme activity result in abnormal nucleoside homeostasis, severe T cell immunodeficiency, neurological dysfunction, and early death.	Nucleosides	18-28	purine-nucleoside phosphorylase	Mus musculus	44-47
16840788-4	2006	In this study, we take advantage of the large species difference that exists between human and rat CNT2 (hCNT2 and rCNT2) in their ability to transport the nucleoside analog drug cladribine, 2CdA, (rCNT2 > > > hCNT2) to identify the critical domains and amino acid residues that contribute to the observed difference in specificity between CNT2 orthologs.	Nucleosides	156-166	solute carrier family 28 member 2	Rattus norvegicus	99-103
16840788-4	2006	In this study, we take advantage of the large species difference that exists between human and rat CNT2 (hCNT2 and rCNT2) in their ability to transport the nucleoside analog drug cladribine, 2CdA, (rCNT2 > > > hCNT2) to identify the critical domains and amino acid residues that contribute to the observed difference in specificity between CNT2 orthologs.	Nucleosides	156-166	solute carrier family 28 member 2	Homo sapiens	105-110
16840788-4	2006	In this study, we take advantage of the large species difference that exists between human and rat CNT2 (hCNT2 and rCNT2) in their ability to transport the nucleoside analog drug cladribine, 2CdA, (rCNT2 > > > hCNT2) to identify the critical domains and amino acid residues that contribute to the observed difference in specificity between CNT2 orthologs.	Nucleosides	156-166	solute carrier family 28 member 2	Rattus norvegicus	115-120
16840788-4	2006	In this study, we take advantage of the large species difference that exists between human and rat CNT2 (hCNT2 and rCNT2) in their ability to transport the nucleoside analog drug cladribine, 2CdA, (rCNT2 > > > hCNT2) to identify the critical domains and amino acid residues that contribute to the observed difference in specificity between CNT2 orthologs.	Nucleosides	156-166	solute carrier family 28 member 2	Rattus norvegicus	198-203
16840788-4	2006	In this study, we take advantage of the large species difference that exists between human and rat CNT2 (hCNT2 and rCNT2) in their ability to transport the nucleoside analog drug cladribine, 2CdA, (rCNT2 > > > hCNT2) to identify the critical domains and amino acid residues that contribute to the observed difference in specificity between CNT2 orthologs.	Nucleosides	156-166	solute carrier family 28 member 2	Rattus norvegicus	106-110
16873718-6	2006	ENT4-mediated nucleoside transport was adenosine selective, sodium independent and only weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine.	Nucleosides	14-24	solute carrier family 29 member 4	Homo sapiens	0-4
16873718-6	2006	ENT4-mediated nucleoside transport was adenosine selective, sodium independent and only weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine.	Nucleosides	150-160	solute carrier family 29 member 4	Homo sapiens	0-4
16619043-0	2006	Chk1-dependent slowing of S-phase progression protects DT40 B-lymphoma cells against killing by the nucleoside analogue 5-fluorouracil.	Nucleosides	100-110	opsin, green sensitive (rhodopsin-like)	Gallus gallus	0-4
16720348-2	2006	Upon availability of ribose-1-phosphate, UPase can also catalyze the formation of nucleosides from uracil as well as from 5-fluorouracil, therefore involved in fluoropyrimidine metabolism.	Nucleosides	82-93	uridine phosphorylase 1	Homo sapiens	41-46
16565170-4	2006	To our knowledge, this is the first demonstration that free nucleosides are substrates of OGG1 and MPG.	Nucleosides	60-71	8-oxoguanine DNA glycosylase	Homo sapiens	90-94
16828706-7	2006	The uptake of [3H]cytidine and [3H]uridine mediated by CNT2 was significantly inhibited by the variety of nucleosides used in this study, except for thymidine, and inhibition of the [3H]uridine uptake by cytidine was competitive.	Nucleosides	106-117	solute carrier family 28 (sodium-coupled nucleoside transporter), member 2	Mus musculus	55-59
16821778-0	2006	Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.	Nucleosides	8-18	Deoxyuridine triphosphatase	Drosophila melanogaster	68-75
16841958-4	2006	We have synthesized the two chiral Sp nucleobases by hydrolysis of the nucleosides denoted by dSp1 and dSp2 according to their elution order in HPLC experiments using a Hypercarb column, and determined their absolute configurations using a combination of experimentally measured optical rotatory dispersion (ORD) spectra in aqueous solutions and computed ORD specific rotations using density functional theory (DFT).	Nucleosides	71-82	Sp1	Drosophila melanogaster	94-98
16841958-4	2006	We have synthesized the two chiral Sp nucleobases by hydrolysis of the nucleosides denoted by dSp1 and dSp2 according to their elution order in HPLC experiments using a Hypercarb column, and determined their absolute configurations using a combination of experimentally measured optical rotatory dispersion (ORD) spectra in aqueous solutions and computed ORD specific rotations using density functional theory (DFT).	Nucleosides	71-82	Ser7	Drosophila melanogaster	103-107
16841958-6	2006	The nucleobases Sp1 and Sp2 exhibit experimentally measured CD and ORD spectra that are very close to those of the respective precursor nucleosides dSp1 and dSp2 in shape and sign.	Nucleosides	136-147	Sp2 transcription factor	Homo sapiens	24-27
16841958-6	2006	The nucleobases Sp1 and Sp2 exhibit experimentally measured CD and ORD spectra that are very close to those of the respective precursor nucleosides dSp1 and dSp2 in shape and sign.	Nucleosides	136-147	Sp1	Drosophila melanogaster	148-152
16841958-7	2006	The first nucleoside stereoisomer (dSp1) to elute from a typical Hypercarb HPLC column has (-)-S, while the second (dSp2) has (+)-R absolute configuration.	Nucleosides	10-20	Sp1	Drosophila melanogaster	35-39
16818276-9	2006	INTERPRETATION AND CONCLUSIONS: These results further support the concept that nucleoside transporters are implicated in the therapeutic response to nucleoside analogs, and suggest a particular and novel role for hENT1 in the genotoxic response to selected nucleoside analogs, such as gemcitabine, in MCL cells.	Nucleosides	79-89	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	213-218
16818276-9	2006	INTERPRETATION AND CONCLUSIONS: These results further support the concept that nucleoside transporters are implicated in the therapeutic response to nucleoside analogs, and suggest a particular and novel role for hENT1 in the genotoxic response to selected nucleoside analogs, such as gemcitabine, in MCL cells.	Nucleosides	149-159	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	213-218
16805837-7	2006	Finally, we showed that inhibition of translational process, but not depression of transcription, prevents the Guo-induced up-regulation of Kir4.1, indicating that this nucleoside acts through de novo protein synthesis.	Nucleosides	169-179	potassium inwardly-rectifying channel, subfamily J, member 10	Rattus norvegicus	140-146
16563876-5	2006	Inhibition of ecto-5"-nucleotidase by concanavalin A (0.1 mg ml-1) produced only a moderate decrease (approximately 25%) on adenosine accumulation in the LM-MP, indicating that the extracellular catabolism of released ATP might not be a major source of the nucleoside.	Nucleosides	257-267	5' nucleotidase, ecto	Rattus norvegicus	14-34
16731618-8	2006	AgnC7 is related to ribonucleotide reductases and could generate the 3"-deoxyarabinose moiety of the nucleoside.	Nucleosides	101-111	heme d1 biosynthesis protein-like protein	Agrobacterium tumefaciens	0-5
16617163-5	2006	The apparent affinities of recombinant transporters (produced in yeast) for a panel of cytosine-containing nucleosides yielded results that were consistent with the observed low-permeant activities of TaraC and araC for hENT1/2 and negligible permeant activities for hCNT1/2/3.	Nucleosides	107-118	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	220-227
16617163-5	2006	The apparent affinities of recombinant transporters (produced in yeast) for a panel of cytosine-containing nucleosides yielded results that were consistent with the observed low-permeant activities of TaraC and araC for hENT1/2 and negligible permeant activities for hCNT1/2/3.	Nucleosides	107-118	solute carrier family 28 member 1	Homo sapiens	267-276
16987056-3	2006	In particular, treatment with nucleoside analogs was found to increase CD40 ligand (CD40L; CD154) levels, an inducible molecule expressed on activated T lymphocytes.	Nucleosides	30-40	CD40 ligand	Homo sapiens	71-82
16987056-3	2006	In particular, treatment with nucleoside analogs was found to increase CD40 ligand (CD40L; CD154) levels, an inducible molecule expressed on activated T lymphocytes.	Nucleosides	30-40	CD40 ligand	Homo sapiens	84-89
16987056-3	2006	In particular, treatment with nucleoside analogs was found to increase CD40 ligand (CD40L; CD154) levels, an inducible molecule expressed on activated T lymphocytes.	Nucleosides	30-40	CD40 ligand	Homo sapiens	91-96
17364060-3	2006	Combination of IFN preparation with some nucleosides, including ribavirin, proved to be highly effective towards drug-resistant herpes virus.	Nucleosides	41-52	interferon alpha 1	Homo sapiens	15-18
16565170-4	2006	To our knowledge, this is the first demonstration that free nucleosides are substrates of OGG1 and MPG.	Nucleosides	60-71	N-methylpurine DNA glycosylase	Homo sapiens	99-102
16691065-2	2006	OBJECTIVES: To compare the change in CD4 cell count over consecutive measurements with VL < 50 copies/ml at both time-points according to nucleoside backbones and other antiretrovirals used.	Nucleosides	141-151	CD4 molecule	Homo sapiens	37-40
16684535-3	2006	To reinvestigate the presence of m6A in mammalian DNA, we used a highly sensitive method capable of detecting one N6-methyldeoxyadenosine per million nucleosides.	Nucleosides	150-161	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	33-36
16691065-6	2006	Comparing two drug nucleoside backbones, there was a lower annual change in CD4 cell count for zidovudine/lamivudine (n = 13038; -15.4/microl; P = 0.012) and for those on tenofovir (n = 1809; -27.3/microl; P = 0.029) compared to lamivudine/stavudine (n = 7339).	Nucleosides	19-29	CD4 molecule	Homo sapiens	76-79
16691065-8	2006	CONCLUSIONS: A nucleoside backbone of zidovudine/lamivudine or any tenofovir-based backbone was associated with significantly poorer increases in CD4 cell count compared to a nucleoside backbone of stavudine/lamivudine, as was an abacavir-based triple nucleoside regimen compared to a boosted protease inhibitor regimen.	Nucleosides	15-25	CD4 molecule	Homo sapiens	146-149
16481390-9	2006	In conclusion, this study supports the hypothesis that APE-1 plays a critical role in the actions of L-configuration but not D-configuration nucleoside analogs.	Nucleosides	141-151	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	55-60
16481390-2	2006	We showed that human apurinic/apyrimidinic endonuclease (APE-1) has exonuclease activity for preferentially removing L-OddC and other L-configuration nucleosides over D-configuration nucleosides from the 3" terminus of DNA in vitro.	Nucleosides	150-161	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	57-62
16807468-11	2006	Also, 5"-nucleotidase opposes the action of nucleoside kinases by catalysing the conversion of nucleotides back to nucleosides.	Nucleosides	115-126	5'-nucleotidase ecto	Homo sapiens	6-21
16481390-2	2006	We showed that human apurinic/apyrimidinic endonuclease (APE-1) has exonuclease activity for preferentially removing L-OddC and other L-configuration nucleosides over D-configuration nucleosides from the 3" terminus of DNA in vitro.	Nucleosides	183-194	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	57-62
16293603-1	2006	Chk1 and Akt signaling facilitate survival of cells treated with nucleoside analogues.	Nucleosides	65-75	checkpoint kinase 1	Homo sapiens	0-4
16669708-2	2006	Nucleosides (1 mM) decreased the radiation-induced yield of 8-oxoguanine in the order Guo > Ino > Ado > Thd > Urd > Cyd.	Nucleosides	0-11	cytochrome b-245, beta polypeptide	Mus musculus	131-134
16582493-1	2006	The human nucleotide-sugar metabolizing enzyme GTP fucose pyrophosphorylase (GFPP) has been purified to homogeneity by an affinity chromatographic procedure that utilizes a novel nucleoside analog.	Nucleosides	179-189	fucose-1-phosphate guanylyltransferase	Homo sapiens	47-75
16582493-1	2006	The human nucleotide-sugar metabolizing enzyme GTP fucose pyrophosphorylase (GFPP) has been purified to homogeneity by an affinity chromatographic procedure that utilizes a novel nucleoside analog.	Nucleosides	179-189	fucose-1-phosphate guanylyltransferase	Homo sapiens	77-81
16550498-0	2006	Improving sensitivity of electrophoretic heteroduplex analysis using nucleosides as additives: Application to the breast cancer predisposition gene BRCA2.	Nucleosides	69-80	BRCA2 DNA repair associated	Homo sapiens	148-153
16337112-1	2006	Multidrug resistance protein-5 (MRP5, ABCC5) is a member of the ATP-binding cassette transporter superfamily that effluxes a broad range of natural and xenobiotic compounds such as cyclic GMP, antiviral compounds, and cancer chemotherapeutic agents including nucleoside-based drugs, antifolate agents and platinum compounds.	Nucleosides	259-269	ATP binding cassette subfamily C member 5	Homo sapiens	0-30
16337112-1	2006	Multidrug resistance protein-5 (MRP5, ABCC5) is a member of the ATP-binding cassette transporter superfamily that effluxes a broad range of natural and xenobiotic compounds such as cyclic GMP, antiviral compounds, and cancer chemotherapeutic agents including nucleoside-based drugs, antifolate agents and platinum compounds.	Nucleosides	259-269	ATP binding cassette subfamily C member 5	Homo sapiens	32-36
16337112-1	2006	Multidrug resistance protein-5 (MRP5, ABCC5) is a member of the ATP-binding cassette transporter superfamily that effluxes a broad range of natural and xenobiotic compounds such as cyclic GMP, antiviral compounds, and cancer chemotherapeutic agents including nucleoside-based drugs, antifolate agents and platinum compounds.	Nucleosides	259-269	ATP binding cassette subfamily C member 5	Homo sapiens	38-43
16525556-1	2006	Oligonucleotides containing acyclic, achiral nucleoside analogues: N-1 or N-9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]nucleobases.	Nucleosides	45-55	PROP paired-like homeobox 1	Homo sapiens	106-112
16533034-1	2006	Human deoxycytidine kinase (dCK) phosphorylates both pyrimidine and purine deoxynucleosides, including numerous nucleoside analogue prodrugs.	Nucleosides	80-90	deoxycytidine kinase	Homo sapiens	6-26
16533034-1	2006	Human deoxycytidine kinase (dCK) phosphorylates both pyrimidine and purine deoxynucleosides, including numerous nucleoside analogue prodrugs.	Nucleosides	80-90	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	28-31
16620092-0	2006	Synthesis and structure of a nucleoside with pi-conjugated nitroxide spin label forming a one-dimensional ferromagnetic chain.	Nucleosides	29-39	spindlin 1	Homo sapiens	69-73
16293603-1	2006	Chk1 and Akt signaling facilitate survival of cells treated with nucleoside analogues.	Nucleosides	65-75	AKT serine/threonine kinase 1	Homo sapiens	9-12
16361699-2	2006	Deoxycytidine kinase (dCK) catalyzes the rate-limiting step of the deoxyribonucleoside salvage pathway in mammalian cells and plays a key role in the activation of numerous nucleoside analogues used in anti-cancer and antiviral chemotherapy.	Nucleosides	76-86	deoxycytidine kinase	Homo sapiens	0-20
16476557-2	2006	These ecto-enzymes hydrolyze extracellular nucleotides to the respective nucleosides.	Nucleosides	73-84	tripartite motif-containing 33	Mus musculus	6-10
16544946-4	2006	Consistently, cis-2-butene-1,4-dial readily reacts with glutathione, amino acids, and nucleosides.	Nucleosides	86-97	suppressor of cytokine signaling 2	Homo sapiens	14-19
16396992-6	2006	Furthermore, the absence of ASF1 leads to a reduced ability to incorporate the nucleoside analog BrdU, indicating that ASF1 is required for efficient DNA replication.	Nucleosides	79-89	anti-silencing factor 1	Drosophila melanogaster	28-32
16396992-6	2006	Furthermore, the absence of ASF1 leads to a reduced ability to incorporate the nucleoside analog BrdU, indicating that ASF1 is required for efficient DNA replication.	Nucleosides	79-89	anti-silencing factor 1	Drosophila melanogaster	119-123
16629121-5	2006	Cytoplasmic 5"-nucleotidase cN-II can degrade this clinically useful cytotoxic nucleoside analogue and its overexpression is thus likely to be involved in resistance to this compound.	Nucleosides	79-89	5'-nucleotidase, cytosolic II	Homo sapiens	28-33
16376308-1	2006	In the present study, we investigated whether an unidentified system for Na(+)-dependent nucleoside transport is expressed by mouse M5076 ovarian sarcoma cells, besides concentrative nucleoside transporter 2 (CNT2(M)), and is involved in the uptake and cytotoxicity of anthracyclines.	Nucleosides	89-99	solute carrier family 28 (sodium-coupled nucleoside transporter), member 2	Mus musculus	169-207
16361699-2	2006	Deoxycytidine kinase (dCK) catalyzes the rate-limiting step of the deoxyribonucleoside salvage pathway in mammalian cells and plays a key role in the activation of numerous nucleoside analogues used in anti-cancer and antiviral chemotherapy.	Nucleosides	76-86	sticky	Drosophila melanogaster	22-25
16421443-5	2006	As a purine-nucleoside analog, clofarabine is a better substrate of dCK than deoxycytidine.	Nucleosides	12-22	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	68-71
16359702-1	2006	Guanosine monophosphate reductase (GMPR) catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP, and plays a critical role in re-utilization of free intracellular bases and purine nucleosides.	Nucleosides	208-219	guanosine monophosphate reductase	Homo sapiens	0-33
16359702-1	2006	Guanosine monophosphate reductase (GMPR) catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP, and plays a critical role in re-utilization of free intracellular bases and purine nucleosides.	Nucleosides	208-219	guanosine monophosphate reductase	Homo sapiens	35-39
16223870-3	2006	Porcine liver carboxylesterase 1 specificity for amino acid esters of three nucleoside analogs [floxuridine, gemcitabine, and 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl) benzimidazole] was evaluated to assess optimal structural preferences for prodrug design.	Nucleosides	76-86	carboxylesterase 1	Homo sapiens	8-32
16394846-10	2006	CONCLUSION: The triple-nucleoside regimen of ABC/3TC/ZDV is a reasonable option for ART-naive patients with a pVL <100,000 copies/mL in whom, for any reason, preferred regimens are not advisable, even in patients with a baseline CD4 cell count <100 cells/mm.	Nucleosides	23-33	CD4 molecule	Homo sapiens	232-235
16223870-5	2006	Carboxylesterase (CES) 1 exhibited high-catalytic efficiency hydrolyzing prodrugs containing a phenylalanyl moiety but was over 100-fold less efficient with valyl or isoleucyl prodrugs, regardless of the nucleoside or esterification site.	Nucleosides	204-214	carboxylesterase 1	Homo sapiens	18-24
16505115-1	2006	Nucleoside anticancer drugs like gemcitabine (2"-deoxy-2",2"-difluorocytidine) are potent inducers of p53, and ectopic expression of wild-type p53 sensitizes cells to these agents.	Nucleosides	0-10	tumor protein p53	Homo sapiens	102-105
16505115-2	2006	However, it is also known that nucleosides are efficient activators of apoptosis in tumor cells that do not express a functional p53.	Nucleosides	31-42	tumor protein p53	Homo sapiens	129-132
16424344-3	2006	The function of DNMT2 is highly conserved, and human DNMT2 protein restored methylation in vitro to tRNA(Asp) from Dnmt2-deficient strains of mouse, Arabidopsis thaliana, and Drosophila melanogaster in a manner that was dependent on preexisting patterns of modified nucleosides.	Nucleosides	266-277	tRNA aspartic acid methyltransferase 1	Homo sapiens	16-21
16505115-3	2006	To clarify this issue, we examined the effects of gemcitabine and 4"-thio-beta-d-arabinofuranosylcytosine (T-ara-C) on p73, a structural and functional homologue of p53, whose activation could also account for nucleoside-induced apoptosis because no functionally significant mutations of p73 have been reported in cancers.	Nucleosides	210-220	tumor protein p73	Homo sapiens	119-122
16505115-9	2006	RNA interference studies show that nucleoside-induced p73 increases are independent of c-Abl, a nucleoside-activated kinase recently implicated in p73 stabilization.	Nucleosides	35-45	tumor protein p73	Homo sapiens	54-57
16505115-9	2006	RNA interference studies show that nucleoside-induced p73 increases are independent of c-Abl, a nucleoside-activated kinase recently implicated in p73 stabilization.	Nucleosides	35-45	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	87-92
16505115-9	2006	RNA interference studies show that nucleoside-induced p73 increases are independent of c-Abl, a nucleoside-activated kinase recently implicated in p73 stabilization.	Nucleosides	35-45	tumor protein p73	Homo sapiens	147-150
16505115-11	2006	Together, these studies indicate that c-Abl-independent p73 stabilization pathways could account for the p53-independent mechanisms in nucleoside-induced apoptosis.	Nucleosides	135-145	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	38-43
16505115-11	2006	Together, these studies indicate that c-Abl-independent p73 stabilization pathways could account for the p53-independent mechanisms in nucleoside-induced apoptosis.	Nucleosides	135-145	tumor protein p73	Homo sapiens	56-59
16505115-11	2006	Together, these studies indicate that c-Abl-independent p73 stabilization pathways could account for the p53-independent mechanisms in nucleoside-induced apoptosis.	Nucleosides	135-145	tumor protein p53	Homo sapiens	105-108
16505115-1	2006	Nucleoside anticancer drugs like gemcitabine (2"-deoxy-2",2"-difluorocytidine) are potent inducers of p53, and ectopic expression of wild-type p53 sensitizes cells to these agents.	Nucleosides	0-10	tumor protein p53	Homo sapiens	143-146
16424344-3	2006	The function of DNMT2 is highly conserved, and human DNMT2 protein restored methylation in vitro to tRNA(Asp) from Dnmt2-deficient strains of mouse, Arabidopsis thaliana, and Drosophila melanogaster in a manner that was dependent on preexisting patterns of modified nucleosides.	Nucleosides	266-277	tRNA aspartic acid methyltransferase 1	Homo sapiens	53-58
16424344-3	2006	The function of DNMT2 is highly conserved, and human DNMT2 protein restored methylation in vitro to tRNA(Asp) from Dnmt2-deficient strains of mouse, Arabidopsis thaliana, and Drosophila melanogaster in a manner that was dependent on preexisting patterns of modified nucleosides.	Nucleosides	266-277	tRNA aspartic acid methyltransferase 1	Homo sapiens	115-120
16394022-0	2006	Mg2+ dependency of HIV-1 reverse transcription, inhibition by nucleoside analogues and resistance.	Nucleosides	62-72	mucin 7, secreted	Homo sapiens	0-3
16929383-4	2006	The Michaelis constant, Km, evidences a higher affinity of both substrates (in particular of more toxic 2"-dAdo) for LADA and proves the modulation of toxic nucleoside neutralization in the extracellular medium due to complex formation between ADA and DPPIV-CD26.	Nucleosides	157-167	dipeptidyl peptidase 4	Bos taurus	252-257
16929383-4	2006	The Michaelis constant, Km, evidences a higher affinity of both substrates (in particular of more toxic 2"-dAdo) for LADA and proves the modulation of toxic nucleoside neutralization in the extracellular medium due to complex formation between ADA and DPPIV-CD26.	Nucleosides	157-167	dipeptidyl peptidase 4	Bos taurus	258-262
16770441-9	2006	cN-I action is crucial during ischemia and important for the efficacy of some nucleoside-based drugs and in the regulation of the substrate pool for nucleic acids synthesis.	Nucleosides	78-88	5'-nucleotidase, cytosolic IA	Homo sapiens	0-4
16298966-1	2005	BGLF4 is the only serine/threonine protein kinase identified in Epstein-Barr virus (EBV); it is known to phosphorylate viral DNA polymerase processivity factor, EA-D (BMRF1), EBNA-LP, EBNA-2, cellular EF-1delta and nucleoside analogue ganciclovir.	Nucleosides	215-225	tegument serine/threonine protein kinase	Human gammaherpesvirus 4	0-5
16497162-5	2006	Hydroxyl radical footprinting and missing nucleoside experiments showed that ATH1 interacts with a 7-bp region of the strand carrying the GAC core.	Nucleosides	42-52	homeobox protein ATH1	Arabidopsis thaliana	77-81
16679527-5	2006	Purine nucleoside phosphorylase catalyzes the phosphorolysis of the N-ribosidic bonds of purine nucleosides and deoxynucleosides.	Nucleosides	96-107	purine nucleoside phosphorylase	Homo sapiens	0-31
17065079-1	2006	Compelling evidence suggests that deoxycytidine kinase (dCK), a key enzyme in the salvage of deoxyribonucleosides and in the activation of clinically relevant nucleoside analogues, can be regulated by reversible phosphorylation.	Nucleosides	102-112	deoxycytidine kinase	Homo sapiens	34-54
17065079-1	2006	Compelling evidence suggests that deoxycytidine kinase (dCK), a key enzyme in the salvage of deoxyribonucleosides and in the activation of clinically relevant nucleoside analogues, can be regulated by reversible phosphorylation.	Nucleosides	102-112	sticky	Drosophila melanogaster	56-59
16397229-5	2006	The endothelial cell line expressing vGPCR was rendered sensitive to treatment with the nucleoside analogue ganciclovir by using a bicistronic construct coexpressing the herpes simplex virus 1 thymidine kinase.	Nucleosides	88-98	K14	Human gammaherpesvirus 8	37-42
16214850-1	2006	The equilibrative nucleoside transporter 2 (ENT2; SLC29A2) is a bidirectional transporter that is involved in the disposition of naturally occurring nucleosides as well as a variety of anticancer and antiviral nucleoside analogs.	Nucleosides	149-160	solute carrier family 29 member 2	Homo sapiens	4-42
16214850-1	2006	The equilibrative nucleoside transporter 2 (ENT2; SLC29A2) is a bidirectional transporter that is involved in the disposition of naturally occurring nucleosides as well as a variety of anticancer and antiviral nucleoside analogs.	Nucleosides	149-160	solute carrier family 29 member 2	Homo sapiens	44-48
16214850-1	2006	The equilibrative nucleoside transporter 2 (ENT2; SLC29A2) is a bidirectional transporter that is involved in the disposition of naturally occurring nucleosides as well as a variety of anticancer and antiviral nucleoside analogs.	Nucleosides	149-160	solute carrier family 29 member 2	Homo sapiens	50-57
16214850-1	2006	The equilibrative nucleoside transporter 2 (ENT2; SLC29A2) is a bidirectional transporter that is involved in the disposition of naturally occurring nucleosides as well as a variety of anticancer and antiviral nucleoside analogs.	Nucleosides	18-28	solute carrier family 29 member 2	Homo sapiens	44-48
16214850-1	2006	The equilibrative nucleoside transporter 2 (ENT2; SLC29A2) is a bidirectional transporter that is involved in the disposition of naturally occurring nucleosides as well as a variety of anticancer and antiviral nucleoside analogs.	Nucleosides	18-28	solute carrier family 29 member 2	Homo sapiens	50-57
16775956-1	2006	The combination therapy regimen of interferon (IFN)-alpha and lamivudine (LAM), a nucleoside analogue, is lately in use in chronic hepatitis B (CHB) infections.	Nucleosides	82-92	interferon alpha 1	Homo sapiens	35-57
17065055-2	2006	Although the mechanism of action of CdA has been extensively investigated in leukemic cells, the possibility that this nucleoside analogue interacts with the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway has never been explored.	Nucleosides	119-129	mitogen-activated protein kinase 1	Homo sapiens	230-234
17065055-2	2006	Although the mechanism of action of CdA has been extensively investigated in leukemic cells, the possibility that this nucleoside analogue interacts with the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway has never been explored.	Nucleosides	119-129	mitogen-activated protein kinase 1	Homo sapiens	235-238
16273408-2	2005	5-Aza-2"-deoxycytidine (decitabine, DAC) is a nucleoside analog, which, at low doses, acts as a hypomethylating agent and is fivefold to tenfold more active than 5-azacytidine (azacitidine, Vidaza)--currently the only approved drug for treatment of myelodysplastic syndrome (MDS).	Nucleosides	46-56	arylacetamide deacetylase	Homo sapiens	36-39
16375757-1	2005	Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2"-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolysis of nucleoside analogues with important antiviral or anticancer properties.	Nucleosides	94-104	thymidine phosphorylase	Homo sapiens	0-23
16375757-1	2005	Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2"-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolysis of nucleoside analogues with important antiviral or anticancer properties.	Nucleosides	94-104	thymidine phosphorylase	Homo sapiens	25-30
16284201-5	2005	Methylation and missing nucleoside interference-based DNA footprints using polypeptides to the N-terminal domain suggest the ZF and Myb motifs bind to regions -3 to -1 and +10 to +15 with reference to the insertion site.	Nucleosides	24-34	Myb transcription factor	Bombyx mori	132-135
16419169-8	2005	To investigate the mechanism of apoptosis induced by nucleosides, it was found that the contents of soluble Fas ligand contents were increased in HepG2 cells following I, U, T, and A treatment (P< 0.05).	Nucleosides	53-64	Fas ligand	Homo sapiens	108-118
16198108-0	2005	Increased muscle nucleoside levels associated with a novel frameshift mutation in the thymidine phosphorylase gene in a Spanish patient with MNGIE.	Nucleosides	17-27	thymidine phosphorylase	Homo sapiens	86-109
16141202-7	2005	In addition to its activity on phosphotyrosine and phosphohistidine substrates, Tdp1 also possesses a limited DNA and RNA 3"-exonuclease activity in which a single nucleoside is removed from the 3"-hydroxyl end of the substrate.	Nucleosides	164-174	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	80-84
15979106-2	2005	Previous results showed that hydrogen peroxide and TNF-alpha increase extracellular inosine concentration in cultured Sertoli cells and this nucleoside protects Sertoli cells against hydrogen peroxide induced damage and participates in TNF-alpha induced nitric oxide production.	Nucleosides	141-151	tumor necrosis factor	Homo sapiens	51-60
15979106-2	2005	Previous results showed that hydrogen peroxide and TNF-alpha increase extracellular inosine concentration in cultured Sertoli cells and this nucleoside protects Sertoli cells against hydrogen peroxide induced damage and participates in TNF-alpha induced nitric oxide production.	Nucleosides	141-151	tumor necrosis factor	Homo sapiens	236-245
15979106-4	2005	The involvement of this nucleoside in the activation of ERK 1/2 by TNF-alpha was also investigated.	Nucleosides	24-34	mitogen-activated protein kinase 3	Homo sapiens	56-63
15979106-4	2005	The involvement of this nucleoside in the activation of ERK 1/2 by TNF-alpha was also investigated.	Nucleosides	24-34	tumor necrosis factor	Homo sapiens	67-76
15979106-9	2005	This nucleoside also participates in TNF-alpha modulation of ERK 1/2.	Nucleosides	5-15	tumor necrosis factor	Homo sapiens	37-46
15979106-9	2005	This nucleoside also participates in TNF-alpha modulation of ERK 1/2.	Nucleosides	5-15	mitogen-activated protein kinase 3	Homo sapiens	61-68
16201812-8	2005	For the 8oxoG:A mismatch that is recognized by the DNA glycosylase MutY, the damaged nucleoside underwent spontaneous and reproducible anti-->syn transitions.	Nucleosides	85-95	synemin	Homo sapiens	145-148
16190908-3	2005	We demonstrate that telencephalic cells from embryonic Gli3Xt/Xt embryos survive better and are more resistant to death induced by cytosine arabinoside, a nucleoside analogue that induces death in neuronal progenitors and neurons, than are control counterparts in vitro.	Nucleosides	155-165	GLI-Kruppel family member GLI3	Mus musculus	55-64
16103768-0	2005	Cumulative exposure to nucleoside analogue reverse transcriptase inhibitors is associated with insulin resistance markers in the Multicenter AIDS Cohort Study.	Nucleosides	23-33	insulin	Homo sapiens	95-102
16245692-8	2005	A qualitative correlation exists between the values of potential energies of the complexes in this conformation and the enzymatic activity of ADA toward the corresponding nucleosides.	Nucleosides	171-182	adenosine deaminase	Homo sapiens	142-145
16094474-0	2005	Structure, reactivity and solution behaviour of [Re(ser)(7-MeG)(CO)(3)] and [Re(ser)(3-pic)(CO)(3)]: "nucleoside-mimicking" complexes based on the fac-[Re(CO)(3)](+) moiety.	Nucleosides	102-112	FA complementation group C	Homo sapiens	147-150
16094474-1	2005	The fac-[Re(CO)(3)](+) moiety was reacted with the amino acid serine (D- and L-ser) and with 7-methylguanine (7-MeG), 3-methylpyridine (3-pic) or adenine (ade) to yield novel complexes intended as nucleoside-mimicking compounds.	Nucleosides	197-207	FA complementation group C	Homo sapiens	4-7
16332576-7	2005	The pattern of inhibition of apical (3)H-uridine, (3)H-inosine and (3)H-thymidine uptake into RTEC cells by physiological nucleosides was consistent with multiple systems: A pyrimidine-selective transport system (CNT1); a broad nucleoside substrate transport system that excludes inosine (CNT4) and an equilibrative NBMPR-insensitive nucleoside transport system (ei type).	Nucleosides	122-133	sodium/nucleoside cotransporter 1	Oryctolagus cuniculus	213-217
16332576-7	2005	The pattern of inhibition of apical (3)H-uridine, (3)H-inosine and (3)H-thymidine uptake into RTEC cells by physiological nucleosides was consistent with multiple systems: A pyrimidine-selective transport system (CNT1); a broad nucleoside substrate transport system that excludes inosine (CNT4) and an equilibrative NBMPR-insensitive nucleoside transport system (ei type).	Nucleosides	122-132	sodium/nucleoside cotransporter 1	Oryctolagus cuniculus	213-217
16014043-1	2005	BACKGROUND: The renal reabsorption of natural nucleosides and a variety of nucleoside-derived drugs relies on the function of the apically located, Na(+)-dependent, concentrative nucleoside transporters CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3).	Nucleosides	46-57	solute carrier family 28 member 1	Rattus norvegicus	203-207
15955867-1	2005	Human concentrative nucleoside transporters 1, 2, and 3 (hCNT1, hCNT2, and hCNT3) exhibit different functional characteristics, and a better understanding of their permeant selectivities is critical for development of nucleoside analog drugs with optimal pharmacokinetic properties.	Nucleosides	20-30	solute carrier family 28 member 1	Homo sapiens	57-62
15955867-1	2005	Human concentrative nucleoside transporters 1, 2, and 3 (hCNT1, hCNT2, and hCNT3) exhibit different functional characteristics, and a better understanding of their permeant selectivities is critical for development of nucleoside analog drugs with optimal pharmacokinetic properties.	Nucleosides	20-30	solute carrier family 28 member 2	Homo sapiens	64-69
15955867-1	2005	Human concentrative nucleoside transporters 1, 2, and 3 (hCNT1, hCNT2, and hCNT3) exhibit different functional characteristics, and a better understanding of their permeant selectivities is critical for development of nucleoside analog drugs with optimal pharmacokinetic properties.	Nucleosides	20-30	solute carrier family 28 member 3	Homo sapiens	75-80
16120774-0	2005	Regulation of human recombinant P2X3 receptors by ecto-protein kinase C. The whole-cell patch-clamp technique was used to record current responses to nucleotides and nucleosides in human embryonic kidney HEK293 cells transfected with the human purinergic P2X3 receptor.	Nucleosides	166-177	purinergic receptor P2X 3	Homo sapiens	32-36
16120774-0	2005	Regulation of human recombinant P2X3 receptors by ecto-protein kinase C. The whole-cell patch-clamp technique was used to record current responses to nucleotides and nucleosides in human embryonic kidney HEK293 cells transfected with the human purinergic P2X3 receptor.	Nucleosides	166-177	tripartite motif containing 33	Homo sapiens	50-54
16212545-0	2005	Structural-functional relationships between terminal deoxynucleotidyltransferase and 5"-triphosphates of nucleoside analogs.	Nucleosides	105-115	DNA nucleotidylexotransferase	Homo sapiens	44-80
16033961-7	2005	This strongly suggests that MCMV M97 has a similar role to HCMV UL97 in the phosphorylation of nucleoside analogue antivirals.	Nucleosides	95-105	tegument serine/threonine protein kinase	Human betaherpesvirus 5	64-68
16085043-1	2005	Human equilibrative, Na(+)-independent nucleoside transport is mediated by membrane proteins sensitive (system es, hENT1) or insensitive (system ei, hENT2) to nitrobenzylthioinosine (NBMPR).	Nucleosides	39-49	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	115-120
16085043-1	2005	Human equilibrative, Na(+)-independent nucleoside transport is mediated by membrane proteins sensitive (system es, hENT1) or insensitive (system ei, hENT2) to nitrobenzylthioinosine (NBMPR).	Nucleosides	39-49	solute carrier family 29 member 2	Homo sapiens	149-154
16014043-1	2005	BACKGROUND: The renal reabsorption of natural nucleosides and a variety of nucleoside-derived drugs relies on the function of the apically located, Na(+)-dependent, concentrative nucleoside transporters CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3).	Nucleosides	46-57	solute carrier family 28 member 2	Rattus norvegicus	209-213
16014043-1	2005	BACKGROUND: The renal reabsorption of natural nucleosides and a variety of nucleoside-derived drugs relies on the function of the apically located, Na(+)-dependent, concentrative nucleoside transporters CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3).	Nucleosides	46-57	solute carrier family 28 member 3	Rattus norvegicus	219-223
15951836-2	2005	The mitochondrial deoxynucleotide carrier (DNC) transports phosphorylated nucleosides for mitochondrial DNA replication and can transport phosphorylated NRTIs into mitochondria.	Nucleosides	74-85	solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19	Mus musculus	43-46
16014043-1	2005	BACKGROUND: The renal reabsorption of natural nucleosides and a variety of nucleoside-derived drugs relies on the function of the apically located, Na(+)-dependent, concentrative nucleoside transporters CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3).	Nucleosides	46-57	solute carrier family 28 member 1	Rattus norvegicus	225-232
16014043-1	2005	BACKGROUND: The renal reabsorption of natural nucleosides and a variety of nucleoside-derived drugs relies on the function of the apically located, Na(+)-dependent, concentrative nucleoside transporters CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3).	Nucleosides	46-57	solute carrier family 28 member 2	Rattus norvegicus	234-241
16014043-1	2005	BACKGROUND: The renal reabsorption of natural nucleosides and a variety of nucleoside-derived drugs relies on the function of the apically located, Na(+)-dependent, concentrative nucleoside transporters CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3).	Nucleosides	46-57	solute carrier family 28 member 3	Rattus norvegicus	247-254
16014043-1	2005	BACKGROUND: The renal reabsorption of natural nucleosides and a variety of nucleoside-derived drugs relies on the function of the apically located, Na(+)-dependent, concentrative nucleoside transporters CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3).	Nucleosides	46-56	solute carrier family 28 member 1	Rattus norvegicus	203-207
16014043-1	2005	BACKGROUND: The renal reabsorption of natural nucleosides and a variety of nucleoside-derived drugs relies on the function of the apically located, Na(+)-dependent, concentrative nucleoside transporters CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3).	Nucleosides	46-56	solute carrier family 28 member 2	Rattus norvegicus	209-213
16014043-1	2005	BACKGROUND: The renal reabsorption of natural nucleosides and a variety of nucleoside-derived drugs relies on the function of the apically located, Na(+)-dependent, concentrative nucleoside transporters CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3).	Nucleosides	46-56	solute carrier family 28 member 3	Rattus norvegicus	219-223
16014043-1	2005	BACKGROUND: The renal reabsorption of natural nucleosides and a variety of nucleoside-derived drugs relies on the function of the apically located, Na(+)-dependent, concentrative nucleoside transporters CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3).	Nucleosides	46-56	solute carrier family 28 member 1	Rattus norvegicus	225-232
16014043-1	2005	BACKGROUND: The renal reabsorption of natural nucleosides and a variety of nucleoside-derived drugs relies on the function of the apically located, Na(+)-dependent, concentrative nucleoside transporters CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3).	Nucleosides	46-56	solute carrier family 28 member 2	Rattus norvegicus	234-241
16014043-1	2005	BACKGROUND: The renal reabsorption of natural nucleosides and a variety of nucleoside-derived drugs relies on the function of the apically located, Na(+)-dependent, concentrative nucleoside transporters CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3).	Nucleosides	46-56	solute carrier family 28 member 3	Rattus norvegicus	247-254
16033254-0	2005	Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism.	Nucleosides	23-33	adenosine deaminase	Homo sapiens	67-86
15876539-3	2005	However, there is no crystal structure of dCK with a bound purine nucleoside, although purines are good substrates for dCK.	Nucleosides	66-76	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	42-45
15983407-1	2005	Purine nucleoside phosphorylase (PNP) is a key enzyme in the purine-salvage pathway, which allows cells to utilize preformed bases and nucleosides in order to synthesize nucleotides.	Nucleosides	135-146	purine nucleoside phosphorylase	Homo sapiens	0-31
15983407-1	2005	Purine nucleoside phosphorylase (PNP) is a key enzyme in the purine-salvage pathway, which allows cells to utilize preformed bases and nucleosides in order to synthesize nucleotides.	Nucleosides	135-146	purine nucleoside phosphorylase	Homo sapiens	33-36
15870078-0	2005	The broadly selective human Na+/nucleoside cotransporter (hCNT3) exhibits novel cation-coupled nucleoside transport characteristics.	Nucleosides	32-42	solute carrier family 28 member 3	Homo sapiens	58-63
15870078-6	2005	Na+ and H+ activated hCNT3 through mechanisms to increase nucleoside apparent binding affinity.	Nucleosides	58-68	solute carrier family 28 member 3	Homo sapiens	21-26
15870078-7	2005	Direct and indirect methods demonstrated cation/nucleoside coupling stoichiometries of 2:1 in the presence of Na+ and both Na+ plus H+, but only 1:1 in the presence of H+ alone, suggesting that hCNT3 possesses two Na+-binding sites, only one of which is shared by H+.	Nucleosides	48-58	solute carrier family 28 member 3	Homo sapiens	194-199
16119458-0	2005	[New non-nucleoside substrates for terminal deoxynucleotidyl transferase: the synthesis and the dependence of substrate properties on structure].	Nucleosides	9-19	DNA nucleotidylexotransferase	Bos taurus	35-72
15982576-8	2005	Biodistribution of [(125)I]IVFRU in nude mice bearing subcutaneous 143B and 143B-LTK tumors revealed widespread distribution of the nucleoside in vivo but with specific localization in 143B-LTK tumors.	Nucleosides	132-142	leukocyte tyrosine kinase	Mus musculus	81-84
15784732-1	2005	Previous studies demonstrated that ataxia telangiectasia mutated- and Rad3-related (ATR) kinase and its downstream target checkpoint kinase 1 (Chk1) facilitate survival of cells treated with nucleoside analogs and other replication inhibitors.	Nucleosides	191-201	checkpoint kinase 1	Homo sapiens	122-141
15784732-1	2005	Previous studies demonstrated that ataxia telangiectasia mutated- and Rad3-related (ATR) kinase and its downstream target checkpoint kinase 1 (Chk1) facilitate survival of cells treated with nucleoside analogs and other replication inhibitors.	Nucleosides	191-201	checkpoint kinase 1	Homo sapiens	143-147
16003293-9	2005	CONCLUSIONS: One week of oral treatment with the nucleoside uptake inhibitor dipyridamole (200 mg, slow release, twice daily) significantly limits ischemia-reperfusion injury in humans in vivo, as assessed by technetium Tc 99m-labeled annexin A5 scintigraphy of forearm skeletal muscle.	Nucleosides	49-59	annexin A5	Homo sapiens	235-245
15888483-3	2005	Extensive literature shows mitochondrial toxicity effects nucleoside analogue reverse transcriptase inhibitors used in the treatment of HIV and chronic hepatitis B as a consequence of an inhibitory effect on Polg.	Nucleosides	58-68	DNA polymerase gamma, catalytic subunit	Homo sapiens	208-212
15793143-0	2005	Excision of nucleoside analogs from DNA by p53 protein, a potential cellular mechanism of resistance to inhibitors of human immunodeficiency virus type 1 reverse transcriptase.	Nucleosides	12-22	tumor protein p53	Homo sapiens	43-46
15962936-2	2005	Its reactive metabolite, cis-2-butene-1,4-dial, reacts with nucleosides to form adducts in vitro.	Nucleosides	60-71	suppressor of cytokine signaling 2	Homo sapiens	25-30
15896365-1	2005	Apyrase/ATP-diphosphohydrolase hydrolyzes di- and triphosphorylated nucleosides in the presence of a bivalent ion with sequential release of orthophosphate.	Nucleosides	68-79	apyrase	Solanum tuberosum	0-7
15896365-1	2005	Apyrase/ATP-diphosphohydrolase hydrolyzes di- and triphosphorylated nucleosides in the presence of a bivalent ion with sequential release of orthophosphate.	Nucleosides	68-79	apyrase	Solanum tuberosum	8-30
15946667-2	2005	In many vertebrate tissues, cytosolic 5"-nucleotidase II (cN-II) either hydrolyses or phosphorylates a number of purine (monophosphorylated) nucleosides through a scheme common to the Haloacid Dehalogenase superfamily members.	Nucleosides	141-152	5'-nucleotidase, cytosolic II	Homo sapiens	28-56
15946667-2	2005	In many vertebrate tissues, cytosolic 5"-nucleotidase II (cN-II) either hydrolyses or phosphorylates a number of purine (monophosphorylated) nucleosides through a scheme common to the Haloacid Dehalogenase superfamily members.	Nucleosides	141-152	5'-nucleotidase, cytosolic II	Homo sapiens	58-63
15913364-4	2005	Moreover, the halogenated nucleosides shift the tautomeric keto-enol equilibrium strongly toward the keto form, with K(TAUT) [keto]/[enol] approximately 10(4) coming close to that of 2"-deoxyguanosine (10(4)-10(5)), while the nonhalogenated 7-deaza-2"-deoxyisoguanosine 2 shows a K(TAUT) of around 2000 and the enol concentration of 1 is 10% in aqueous solution.	Nucleosides	26-37	solute carrier family 6 member 6	Homo sapiens	119-123
15913364-4	2005	Moreover, the halogenated nucleosides shift the tautomeric keto-enol equilibrium strongly toward the keto form, with K(TAUT) [keto]/[enol] approximately 10(4) coming close to that of 2"-deoxyguanosine (10(4)-10(5)), while the nonhalogenated 7-deaza-2"-deoxyisoguanosine 2 shows a K(TAUT) of around 2000 and the enol concentration of 1 is 10% in aqueous solution.	Nucleosides	26-37	solute carrier family 6 member 6	Homo sapiens	282-286
15645422-0	2005	Anti-tumor efficacy of the nucleoside analog 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl) cytosine (4"-thio-FAC) in human pancreatic and ovarian tumor xenograft models.	Nucleosides	27-37	FA complementation group C	Homo sapiens	115-118
15897250-10	2005	Thus, MRP5 transports the monophosphorylated metabolite of this nucleoside and when MRP5 is overexpressed in colorectal and breast tumors, it may contribute to 5-FU drug resistance.	Nucleosides	64-74	ATP binding cassette subfamily C member 5	Homo sapiens	6-10
15897250-10	2005	Thus, MRP5 transports the monophosphorylated metabolite of this nucleoside and when MRP5 is overexpressed in colorectal and breast tumors, it may contribute to 5-FU drug resistance.	Nucleosides	64-74	ATP binding cassette subfamily C member 5	Homo sapiens	84-88
15752710-2	2005	Formation of dATP requires phosphorylation of deoxyadenosine by deoxycytidine kinase (dCK), the main nucleoside salvage enzyme in lymphoid cells.	Nucleosides	101-111	deoxycytidine kinase	Homo sapiens	64-84
15752710-2	2005	Formation of dATP requires phosphorylation of deoxyadenosine by deoxycytidine kinase (dCK), the main nucleoside salvage enzyme in lymphoid cells.	Nucleosides	101-111	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	86-89
15793143-1	2005	We investigated the ability of p53 in cytoplasm to excise nucleoside analogs (NAs).	Nucleosides	58-68	tumor protein p53	Homo sapiens	31-34
15793143-2	2005	A decrease in incorporation of NAs by human immunodeficiency virus type 1 reverse transcriptase and their excision from DNA by p53, provided by the cytoplasmic fraction of LCC2 cells, suggest that p53 in cytoplasm may act as an external proofreader for NA incorporation.	Nucleosides	31-34	tumor protein p53	Homo sapiens	197-200
15827340-3	2005	Previous studies with amino acid ester prodrugs of nucleoside drugs targeted to the PEPT1 transporter coupled with recent findings of the functional expression of the PEPT1 oligopeptide transporter in pancreatic adenocarcinoma cell lines suggest the potential of PEPT1 as therapeutic targets for cancer treatment.	Nucleosides	51-61	solute carrier family 15 member 1	Homo sapiens	84-89
15529184-3	2005	Since some nucleoside analogs have a role in treating patients with non-Hodgkin"s lymphoma (NHL), this study was undertaken to assess hENT1 abundance in NHL.	Nucleosides	11-21	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	134-139
15529184-12	2005	Prospective studies to assess the value of hENT1 immunostaining in predicting resistance to nucleoside chemotherapy for NHL are warranted.	Nucleosides	92-102	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	43-48
15827327-4	2005	Although MRP4 is known to transport some nucleoside analogues, it has not previously been associated with resistance to drugs used to treat solid tumors.	Nucleosides	41-51	ATP binding cassette subfamily C member 4	Homo sapiens	9-13
15649894-8	2005	This study demonstrated that the corresponding residues in TMs 1 and 11 of hENT1, hENT2, and CeENT1 are important for dipyridamole interactions and nucleoside transport.	Nucleosides	148-158	PYD and CARD domain containing	Homo sapiens	59-64
15769872-3	2005	By analyzing modified nucleosides in individual tRNA species, we show that the ELP1-ELP6 and KTI11-KTI13 genes are all required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA.	Nucleosides	22-33	Elongator subunit IKI3	Saccharomyces cerevisiae S288C	79-83
15769872-3	2005	By analyzing modified nucleosides in individual tRNA species, we show that the ELP1-ELP6 and KTI11-KTI13 genes are all required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA.	Nucleosides	22-33	Elongator subunit ELP6	Saccharomyces cerevisiae S288C	84-88
15769872-3	2005	By analyzing modified nucleosides in individual tRNA species, we show that the ELP1-ELP6 and KTI11-KTI13 genes are all required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA.	Nucleosides	22-33	Kti11p	Saccharomyces cerevisiae S288C	93-98
15769872-3	2005	By analyzing modified nucleosides in individual tRNA species, we show that the ELP1-ELP6 and KTI11-KTI13 genes are all required for an early step in synthesis of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups present on uridines at the wobble position in tRNA.	Nucleosides	22-33	Ats1p	Saccharomyces cerevisiae S288C	99-104
15644498-1	2005	Human equilibrative nucleoside transporters 1 and 2 (hENT1 and hENT2) differ functionally in that hENT2 generally displays lower affinity for its nucleoside permeants and is less sensitive to inhibition by the coronary vasodilators dilazep and dipyridamole.	Nucleosides	20-30	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	53-58
15644498-1	2005	Human equilibrative nucleoside transporters 1 and 2 (hENT1 and hENT2) differ functionally in that hENT2 generally displays lower affinity for its nucleoside permeants and is less sensitive to inhibition by the coronary vasodilators dilazep and dipyridamole.	Nucleosides	20-30	solute carrier family 29 member 2	Homo sapiens	63-68
15644498-1	2005	Human equilibrative nucleoside transporters 1 and 2 (hENT1 and hENT2) differ functionally in that hENT2 generally displays lower affinity for its nucleoside permeants and is less sensitive to inhibition by the coronary vasodilators dilazep and dipyridamole.	Nucleosides	20-30	solute carrier family 29 member 2	Homo sapiens	98-103
15649894-8	2005	This study demonstrated that the corresponding residues in TMs 1 and 11 of hENT1, hENT2, and CeENT1 are important for dipyridamole interactions and nucleoside transport.	Nucleosides	148-158	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	75-80
15649894-8	2005	This study demonstrated that the corresponding residues in TMs 1 and 11 of hENT1, hENT2, and CeENT1 are important for dipyridamole interactions and nucleoside transport.	Nucleosides	148-158	solute carrier family 29 member 2	Homo sapiens	82-87
15649894-8	2005	This study demonstrated that the corresponding residues in TMs 1 and 11 of hENT1, hENT2, and CeENT1 are important for dipyridamole interactions and nucleoside transport.	Nucleosides	148-158	Equilibrative Nucleoside Transporter	Caenorhabditis elegans	93-99
15861042-1	2005	INTRODUCTION: Human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), which mediates transport of purine and pyrimidine nucleosides and a variety of antiviral and anticancer nucleoside drugs, was investigated to determine if there are single nucleotide polymorphisms in the coding regions of the hCNT3 gene.	Nucleosides	34-44	solute carrier family 28 member 3	Homo sapiens	60-65
15764852-1	2005	OBJECTIVE: To evaluate whether an inter-individual variability in the activity of thymidine kinase (TK) and deoxycytidine kinase (dCK), which are involved in the first step of phosphorylation of some nucleoside analogues, exists in antiretroviral-naive, HIV-seropositive patients.	Nucleosides	200-210	deoxycytidine kinase	Homo sapiens	108-128
15764852-1	2005	OBJECTIVE: To evaluate whether an inter-individual variability in the activity of thymidine kinase (TK) and deoxycytidine kinase (dCK), which are involved in the first step of phosphorylation of some nucleoside analogues, exists in antiretroviral-naive, HIV-seropositive patients.	Nucleosides	200-210	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	130-133
15714420-0	2005	Development of HIV with drug resistance after CD4 cell count-guided structured treatment interruptions in patients treated with highly active antiretroviral therapy after dual-nucleoside analogue treatment.	Nucleosides	176-186	CD4 molecule	Homo sapiens	46-49
15812229-1	2005	The E. coli PNP suicide gene sensitizes solid tumors to nucleoside prodrugs, such as 6-methylpurine-2"-deoxyriboside (MeP-dR).	Nucleosides	56-66	purine nucleoside phosphorylase	Homo sapiens	12-15
15861042-1	2005	INTRODUCTION: Human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), which mediates transport of purine and pyrimidine nucleosides and a variety of antiviral and anticancer nucleoside drugs, was investigated to determine if there are single nucleotide polymorphisms in the coding regions of the hCNT3 gene.	Nucleosides	34-44	solute carrier family 28 member 3	Homo sapiens	67-74
15861042-1	2005	INTRODUCTION: Human concentrative nucleoside transporter 3, hCNT3 (SLC28A3), which mediates transport of purine and pyrimidine nucleosides and a variety of antiviral and anticancer nucleoside drugs, was investigated to determine if there are single nucleotide polymorphisms in the coding regions of the hCNT3 gene.	Nucleosides	34-44	solute carrier family 28 member 3	Homo sapiens	303-308
15704953-9	2005	It was found that a calculated preference for the syn versus the anti nucleoside conformation correlates to an experimentally better substrate: the OMP and 4-thio-OMP models show a preference for syn conformations, whereas the 2-thio-OMP (the only substrate of the three OMPs that is experimentally found to bind poorly) model shows a preference for an anti conformation.	Nucleosides	70-80	synemin	Homo sapiens	50-53
15704953-9	2005	It was found that a calculated preference for the syn versus the anti nucleoside conformation correlates to an experimentally better substrate: the OMP and 4-thio-OMP models show a preference for syn conformations, whereas the 2-thio-OMP (the only substrate of the three OMPs that is experimentally found to bind poorly) model shows a preference for an anti conformation.	Nucleosides	70-80	olfactory marker protein	Homo sapiens	148-151
15704953-9	2005	It was found that a calculated preference for the syn versus the anti nucleoside conformation correlates to an experimentally better substrate: the OMP and 4-thio-OMP models show a preference for syn conformations, whereas the 2-thio-OMP (the only substrate of the three OMPs that is experimentally found to bind poorly) model shows a preference for an anti conformation.	Nucleosides	70-80	olfactory marker protein	Homo sapiens	163-166
15704953-9	2005	It was found that a calculated preference for the syn versus the anti nucleoside conformation correlates to an experimentally better substrate: the OMP and 4-thio-OMP models show a preference for syn conformations, whereas the 2-thio-OMP (the only substrate of the three OMPs that is experimentally found to bind poorly) model shows a preference for an anti conformation.	Nucleosides	70-80	synemin	Homo sapiens	196-199
15704953-9	2005	It was found that a calculated preference for the syn versus the anti nucleoside conformation correlates to an experimentally better substrate: the OMP and 4-thio-OMP models show a preference for syn conformations, whereas the 2-thio-OMP (the only substrate of the three OMPs that is experimentally found to bind poorly) model shows a preference for an anti conformation.	Nucleosides	70-80	olfactory marker protein	Homo sapiens	163-166
16101455-7	2005	Nevertheless, MEK blockade efficiently and selectively sensitizes leukemic cells to sub-optimal doses of other apoptotic stimuli, including classical cytotoxics (nucleoside analogs, microtubule-targeted drugs, gamma-irradiation), biologicals (retinoids, interferons, arsenic trioxide), and, most interestingly, other signal transduction/apoptosis modulators (UCN-01, STI571, Bcl-2 antagonists).	Nucleosides	162-172	mitogen-activated protein kinase kinase 7	Homo sapiens	14-17
15547112-8	2005	These results demonstrated that Sertoli cells are equipped with multiple nucleoside transport systems, including ENT1, ENT2, and CNTs, to provide nucleosides for spermatogenesis.	Nucleosides	73-83	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	113-117
15547112-8	2005	These results demonstrated that Sertoli cells are equipped with multiple nucleoside transport systems, including ENT1, ENT2, and CNTs, to provide nucleosides for spermatogenesis.	Nucleosides	73-83	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	119-123
15547112-8	2005	These results demonstrated that Sertoli cells are equipped with multiple nucleoside transport systems, including ENT1, ENT2, and CNTs, to provide nucleosides for spermatogenesis.	Nucleosides	146-157	solute carrier family 29 (nucleoside transporters), member 1	Mus musculus	113-117
15547112-8	2005	These results demonstrated that Sertoli cells are equipped with multiple nucleoside transport systems, including ENT1, ENT2, and CNTs, to provide nucleosides for spermatogenesis.	Nucleosides	146-157	solute carrier family 29 (nucleoside transporters), member 2	Mus musculus	119-123
15861032-1	2005	The concentrative nucleoside transporter CNT2 (SPNT1; SLC28A2) plays a role in the absorption and disposition of naturally occurring nucleosides, as well as nucleoside analog drugs.	Nucleosides	18-28	solute carrier family 28 member 2	Homo sapiens	54-61
15861032-2	2005	The aim of the present study was to characterize genetic variation in SLC28A2, the gene encoding CNT2, and to functionally analyse non-synonymous variants of CNT2, as a first step towards understanding whether genetic variation in this nucleoside transporter contributes to variation in response to nucleoside analogs.	Nucleosides	236-246	solute carrier family 28 member 2	Homo sapiens	158-162
15861032-8	2005	The variant CNT2-F355S exhibited a change in specificity for the naturally occurring nucleosides, inosine and uridine.	Nucleosides	85-96	solute carrier family 28 member 2	Homo sapiens	12-16
15861032-10	2005	However, CNT2-F355S (3% allele frequency in the African-American sample) was found to alter specificity for naturally occurring nucleosides, which may have implications for nucleoside homeostasis.	Nucleosides	128-139	solute carrier family 28 member 2	Homo sapiens	9-13
15861032-10	2005	However, CNT2-F355S (3% allele frequency in the African-American sample) was found to alter specificity for naturally occurring nucleosides, which may have implications for nucleoside homeostasis.	Nucleosides	128-138	solute carrier family 28 member 2	Homo sapiens	9-13
16305527-7	2005	Moreover, TK-2 has been suggested to be implicated in mitochondrial toxicity associated to prolonged treatments with nucleoside analogues (i.e AZT for the treatment of AIDS patients).	Nucleosides	117-127	thymidine kinase 2	Homo sapiens	10-14
15673733-1	2005	beta-L-3"-Fluoro-2",3"-didehydro-2",3"-dideoxycytidine (L-3"-Fd4C) is a potent and selective antiretroviral nucleoside with activity against lamivudine-resistant human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV) in vitro.	Nucleosides	108-118	immunoglobulin kappa variable 2-14 (pseudogene)	Homo sapiens	5-8
15673733-1	2005	beta-L-3"-Fluoro-2",3"-didehydro-2",3"-dideoxycytidine (L-3"-Fd4C) is a potent and selective antiretroviral nucleoside with activity against lamivudine-resistant human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV) in vitro.	Nucleosides	108-118	immunoglobulin kappa variable 2-14 (pseudogene)	Homo sapiens	56-59
15678421-2	2005	This novel nucleoside analogue was efficiently incorporated at the 3"-termini of DNA by terminal deoxynucleotidyl transferase (TdT).	Nucleosides	11-21	DNA nucleotidylexotransferase	Homo sapiens	88-125
15678421-2	2005	This novel nucleoside analogue was efficiently incorporated at the 3"-termini of DNA by terminal deoxynucleotidyl transferase (TdT).	Nucleosides	11-21	DNA nucleotidylexotransferase	Homo sapiens	127-130
15861032-1	2005	The concentrative nucleoside transporter CNT2 (SPNT1; SLC28A2) plays a role in the absorption and disposition of naturally occurring nucleosides, as well as nucleoside analog drugs.	Nucleosides	133-144	solute carrier family 28 member 2	Homo sapiens	41-45
15861032-1	2005	The concentrative nucleoside transporter CNT2 (SPNT1; SLC28A2) plays a role in the absorption and disposition of naturally occurring nucleosides, as well as nucleoside analog drugs.	Nucleosides	133-144	solute carrier family 28 member 2	Homo sapiens	47-52
15861032-1	2005	The concentrative nucleoside transporter CNT2 (SPNT1; SLC28A2) plays a role in the absorption and disposition of naturally occurring nucleosides, as well as nucleoside analog drugs.	Nucleosides	133-144	solute carrier family 28 member 2	Homo sapiens	54-61
15861032-1	2005	The concentrative nucleoside transporter CNT2 (SPNT1; SLC28A2) plays a role in the absorption and disposition of naturally occurring nucleosides, as well as nucleoside analog drugs.	Nucleosides	18-28	solute carrier family 28 member 2	Homo sapiens	41-45
15861032-1	2005	The concentrative nucleoside transporter CNT2 (SPNT1; SLC28A2) plays a role in the absorption and disposition of naturally occurring nucleosides, as well as nucleoside analog drugs.	Nucleosides	18-28	solute carrier family 28 member 2	Homo sapiens	47-52
15807433-3	2005	The treatment of K562 cells with nucleosides only was accompanied by the activation of caspase-3 and caspase-9, rather than caspase-6, increased fluorescence of ethidium bromide and DAPI upon binding to DNA, and apoptosis.	Nucleosides	33-44	caspase 3	Homo sapiens	87-96
15911984-3	2005	Previous results have shown that the catabolic rate-limiting enzymes DPD and NT, which are important membranous transporter of nucleosides, may regulate the sensitivity to 5-FU.	Nucleosides	127-138	dihydropyrimidine dehydrogenase	Homo sapiens	69-72
16438058-3	2005	The orientation of the oxadiazole carboxamide nucleobase moiety was determined as anti (conformer A) and high anti (conformer B) in the case of the nucleoside analog 1 whereas the syn conformation is adapted by the unnatural nucleoside 2.	Nucleosides	148-158	synemin	Homo sapiens	180-183
15807433-2	2005	The exposure of cancer cells to combinations of phorbol 12-myrsitate 13-acetate (100 nM) nucleosides for two days led to a loss of hemoglobin production (marker of erythroid differentiation) in cells and increased expression of monocyte-macrophage lineage associated surface antigen CD14.	Nucleosides	89-100	CD14 molecule	Homo sapiens	283-287
15807433-3	2005	The treatment of K562 cells with nucleosides only was accompanied by the activation of caspase-3 and caspase-9, rather than caspase-6, increased fluorescence of ethidium bromide and DAPI upon binding to DNA, and apoptosis.	Nucleosides	33-44	caspase 9	Homo sapiens	101-110
15807433-3	2005	The treatment of K562 cells with nucleosides only was accompanied by the activation of caspase-3 and caspase-9, rather than caspase-6, increased fluorescence of ethidium bromide and DAPI upon binding to DNA, and apoptosis.	Nucleosides	33-44	caspase 6	Homo sapiens	124-133
15807433-4	2005	Intracellular activation of caspase-6, inhibition of caspase-9, a markedly decreased activity of caspase-3 and of fluorescence of DNA-binding dyes, and inhibition of apoptosis were observed when the cells were treated with phorbol 12-myeristet 13-acetate combined with nucleosides.	Nucleosides	269-280	caspase 6	Homo sapiens	28-37
15544576-5	2004	Five single nucleoside polymorphisms of the TPH1 gene were studied in a population-based sample of postpartum Taiwanese women consisting of 120 subjects with depression or/and anxiety and 86 matched normal controls.	Nucleosides	12-22	tryptophan hydroxylase 1	Homo sapiens	44-48
15651758-0	2004	Interaction of nucleoside inhibitors of HIV-1 reverse transcriptase with the concentrative nucleoside transporter-1 (SLC28A1).	Nucleosides	15-25	solute carrier family 28 member 1	Homo sapiens	77-115
15651758-0	2004	Interaction of nucleoside inhibitors of HIV-1 reverse transcriptase with the concentrative nucleoside transporter-1 (SLC28A1).	Nucleosides	15-25	solute carrier family 28 member 1	Homo sapiens	117-124
15738947-1	2005	The human concentrative nucleoside transporter, CNT3 (SLC28A3), plays an important role in mediating the cellular entry of a broad array of physiological nucleosides and synthetic anticancer nucleoside analog drugs.	Nucleosides	154-165	solute carrier family 28 member 3	Homo sapiens	48-52
15738947-1	2005	The human concentrative nucleoside transporter, CNT3 (SLC28A3), plays an important role in mediating the cellular entry of a broad array of physiological nucleosides and synthetic anticancer nucleoside analog drugs.	Nucleosides	154-165	solute carrier family 28 member 3	Homo sapiens	54-61
15738947-1	2005	The human concentrative nucleoside transporter, CNT3 (SLC28A3), plays an important role in mediating the cellular entry of a broad array of physiological nucleosides and synthetic anticancer nucleoside analog drugs.	Nucleosides	24-34	solute carrier family 28 member 3	Homo sapiens	48-52
15738947-1	2005	The human concentrative nucleoside transporter, CNT3 (SLC28A3), plays an important role in mediating the cellular entry of a broad array of physiological nucleosides and synthetic anticancer nucleoside analog drugs.	Nucleosides	24-34	solute carrier family 28 member 3	Homo sapiens	54-61
16206154-1	2005	Many nucleosides and their modified forms have been studied by mass spectrometry elaborating the detailed fragmentation pathways under MS2 and MS(n) conditions.	Nucleosides	5-16	MS2	Homo sapiens	135-138
15516989-10	2004	Thus, we conclude that apoptosis induced by nucleoside analogues is independent from death receptor signaling as well as from a proposed direct effect on APAF-1, but rather follows the mitochondrial signaling pathway of cytochrome c release and subsequent processing of caspase-9 and -3.	Nucleosides	44-54	apoptotic peptidase activating factor 1	Homo sapiens	154-160
15516989-10	2004	Thus, we conclude that apoptosis induced by nucleoside analogues is independent from death receptor signaling as well as from a proposed direct effect on APAF-1, but rather follows the mitochondrial signaling pathway of cytochrome c release and subsequent processing of caspase-9 and -3.	Nucleosides	44-54	cytochrome c, somatic	Homo sapiens	220-232
15516989-10	2004	Thus, we conclude that apoptosis induced by nucleoside analogues is independent from death receptor signaling as well as from a proposed direct effect on APAF-1, but rather follows the mitochondrial signaling pathway of cytochrome c release and subsequent processing of caspase-9 and -3.	Nucleosides	44-54	caspase 9	Homo sapiens	270-286
15548386-1	2004	Deoxycytidine kinase (EC 2.7.1.74, dCK) catalyzes the phosphorylation of deoxynucleosides and several nucleoside analogues that are important in antiviral and cancer chemotherapy.	Nucleosides	78-88	deoxycytidine kinase	Mus musculus	0-20
15548386-1	2004	Deoxycytidine kinase (EC 2.7.1.74, dCK) catalyzes the phosphorylation of deoxynucleosides and several nucleoside analogues that are important in antiviral and cancer chemotherapy.	Nucleosides	78-88	sticky	Drosophila melanogaster	35-38
15575754-2	2004	In fact, the reaction of 7, easily prepared by reaction of 5"-O-Tosyl TSAO-T under basic nonnucleophilic conditions (potassium carbonate), with different classes of nucleophiles, for example, nitrogen-, oxygen-, sulfur-, and carbon-based nucleophiles, or with amino acids afforded, with total regio- and stereoselectivity, new bi-, tri-, and tetracyclic nucleosides.	Nucleosides	354-365	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	332-335
15349753-1	2004	PURPOSE: Gemcitabine and cladribine (2CdA) are nucleoside analogues that decrease DNA synthesis via inhibition of ribonucleotide reductase; the combination could be additive or synergistic.	Nucleosides	47-57	cytidine deaminase	Homo sapiens	38-41
15606136-6	2004	The characterization of the primary and secondary products formed in the reaction of cis-2-butene-1,4-dial with nucleosides is important for understanding the mechanism of furan-induced carcinogenesis.	Nucleosides	112-123	suppressor of cytokine signaling 2	Homo sapiens	85-90
15509173-9	2004	The results suggest that the ring-contracted nucleoside analogues of TCRB and BDCRB interacted weakly or not at all with viral and cellular targets.	Nucleosides	45-55	T cell receptor beta constant 1	Homo sapiens	69-73
15576352-5	2004	Unlike 1-meA and 3-meC, nucleosides or bases corresponding to 1-meG or 3-meT did not stimulate the uncoupled, AlkB-mediated decarboxylation of 2-oxoglutarate.	Nucleosides	24-35	protein tyrosine phosphatase non-receptor type 4	Homo sapiens	64-67
15364914-1	2004	Multidrug resistance protein 4 (MRP4/ABCC4), transports cyclic nucleoside monophosphates, nucleoside analog drugs, chemotherapeutic agents, and prostaglandins.	Nucleosides	63-73	ATP binding cassette subfamily C member 4	Homo sapiens	32-36
15364914-1	2004	Multidrug resistance protein 4 (MRP4/ABCC4), transports cyclic nucleoside monophosphates, nucleoside analog drugs, chemotherapeutic agents, and prostaglandins.	Nucleosides	63-73	ATP binding cassette subfamily C member 4	Homo sapiens	37-42
15448350-8	2004	From HPLC analysis, the recombinant GIV PNP protein was shown to catalyse the reversible phosphorolysis of purine nucleosides and could accept guanosine, inosine and adenosine as substrates.	Nucleosides	114-125	purine nucleoside phosphorylase	Homo sapiens	40-43
15504900-10	2004	A proliferative stimulus induces the equilibrative nucleoside activities (mostly through ENT1) known to be located at the basolateral membrane, allowing the uptake of nucleosides from the bloodstream for the increased demands of the proliferating cell.	Nucleosides	51-61	solute carrier family 29 member 1	Rattus norvegicus	89-93
15504900-10	2004	A proliferative stimulus induces the equilibrative nucleoside activities (mostly through ENT1) known to be located at the basolateral membrane, allowing the uptake of nucleosides from the bloodstream for the increased demands of the proliferating cell.	Nucleosides	167-178	solute carrier family 29 member 1	Rattus norvegicus	89-93
15543539-2	2004	The single Ser/Gly difference between CaCNT/19-20196 and CaCNT occurs at position 328 in putative TM 7, and corresponds to a Ser/Gly substitution previously shown to contribute to the contrasting pyrimidine and purine nucleoside selectivities of human (h) and rat (r) Na+-dependent CNT1 and CNT2.	Nucleosides	218-228	solute carrier family 28 member 1	Rattus norvegicus	282-286
15543539-2	2004	The single Ser/Gly difference between CaCNT/19-20196 and CaCNT occurs at position 328 in putative TM 7, and corresponds to a Ser/Gly substitution previously shown to contribute to the contrasting pyrimidine and purine nucleoside selectivities of human (h) and rat (r) Na+-dependent CNT1 and CNT2.	Nucleosides	218-228	solute carrier family 28 member 2	Rattus norvegicus	291-295
16028355-1	2004	Biphenyl hydrolase-like (BPHL) protein is a novel serine hydrolase which has been identified as human valacyclovirase (VACVase), catalyzing the hydrolytic activation of valine ester prodrugs of the antiviral drugs acyclovir and ganciclovir as well as other amino acid ester prodrugs of therapeutic nucleoside analogues.	Nucleosides	298-308	biphenyl hydrolase like	Homo sapiens	0-30
16028355-1	2004	Biphenyl hydrolase-like (BPHL) protein is a novel serine hydrolase which has been identified as human valacyclovirase (VACVase), catalyzing the hydrolytic activation of valine ester prodrugs of the antiviral drugs acyclovir and ganciclovir as well as other amino acid ester prodrugs of therapeutic nucleoside analogues.	Nucleosides	298-308	biphenyl hydrolase like	Homo sapiens	102-117
16028355-1	2004	Biphenyl hydrolase-like (BPHL) protein is a novel serine hydrolase which has been identified as human valacyclovirase (VACVase), catalyzing the hydrolytic activation of valine ester prodrugs of the antiviral drugs acyclovir and ganciclovir as well as other amino acid ester prodrugs of therapeutic nucleoside analogues.	Nucleosides	298-308	biphenyl hydrolase like	Homo sapiens	119-126
16028355-2	2004	The broad specificity for nucleoside analogues as parent drugs suggests that BPHL may be particularly useful as a molecular target for prodrug activation.	Nucleosides	26-36	biphenyl hydrolase like	Homo sapiens	77-81
15571259-1	2004	Recent studies indicate that deoxycytidine kinase (dCK), which activates various nucleoside analogues used in antileukemic therapy, can be regulated by post-translational modification, most probably through reversible phosphorylation.	Nucleosides	81-91	deoxycytidine kinase	Homo sapiens	29-49
15280363-6	2004	Co-expression of AtIPT4 and CYP735A enabled yeast to excrete tZ and the nucleosides to the culture medium.	Nucleosides	72-83	isopentenyltransferase 4	Arabidopsis thaliana	17-23
15532538-1	2004	The sequential hydrolysis of purines is present in rat CSF and generates nucleosides as inosine and guanosine that are usual substrates for purine nucleoside phosphorylase (PNP).	Nucleosides	73-84	purine nucleoside phosphorylase	Rattus norvegicus	140-171
15532538-1	2004	The sequential hydrolysis of purines is present in rat CSF and generates nucleosides as inosine and guanosine that are usual substrates for purine nucleoside phosphorylase (PNP).	Nucleosides	73-84	purine nucleoside phosphorylase	Rattus norvegicus	173-176
15532538-3	2004	Here we investigated the presence of PNP in CSF of rats using: i) a specific chromophoric analogue of nucleosides, 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG), and ii) an inhibitor of PNP activity, immucillin-H.	Nucleosides	102-113	purine nucleoside phosphorylase	Rattus norvegicus	37-40
15571274-1	2004	The uptake of nucleosides and nucleoside analogs into human leukemia K562 cells is facilitated by the equilibrative transporters ENT1 and ENT2.	Nucleosides	14-24	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	129-133
15571233-4	2004	TP is a cytosolic enzyme required for nucleoside homeostasis.	Nucleosides	38-48	thymidine phosphorylase	Homo sapiens	0-2
15571274-1	2004	The uptake of nucleosides and nucleoside analogs into human leukemia K562 cells is facilitated by the equilibrative transporters ENT1 and ENT2.	Nucleosides	14-24	solute carrier family 29 member 2	Homo sapiens	138-142
15571259-1	2004	Recent studies indicate that deoxycytidine kinase (dCK), which activates various nucleoside analogues used in antileukemic therapy, can be regulated by post-translational modification, most probably through reversible phosphorylation.	Nucleosides	81-91	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	51-54
15571274-1	2004	The uptake of nucleosides and nucleoside analogs into human leukemia K562 cells is facilitated by the equilibrative transporters ENT1 and ENT2.	Nucleosides	14-25	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	129-133
15571274-1	2004	The uptake of nucleosides and nucleoside analogs into human leukemia K562 cells is facilitated by the equilibrative transporters ENT1 and ENT2.	Nucleosides	14-25	solute carrier family 29 member 2	Homo sapiens	138-142
15324946-6	2004	With the introduction of new nucleoside/nucleotide analogs such as entacavir, clevudine, LFd4C,tenofovir, and immunomodulatory agents such as pegylated IFN, new treatment options, either alone or in combination, are being investigated to increase the response rate in treatment-naive and treatment-experienced chronic hepatitis B patients.	Nucleosides	29-39	interferon alpha 1	Homo sapiens	152-155
15294454-2	2004	We have found that human MDR1 transfected murine L1210/VMDRC.06 leukemia cells exhibit relatively large amounts of Pgp and high levels of resistance to 6-mercaptopurine [6-MP] and other purine and pyrimidine nucleobase and nucleoside analogs.	Nucleosides	223-233	ATP binding cassette subfamily B member 1	Homo sapiens	25-29
15322179-8	2004	Folate or nucleoside repletion of folate-deficient cells rapidly restored T lymphocyte proliferation and normal cell cycle, reduced the DNA uracil content, and lowered the CD4(+) to CD8(+) ratio.	Nucleosides	10-20	CD4 molecule	Homo sapiens	172-175
15322179-8	2004	Folate or nucleoside repletion of folate-deficient cells rapidly restored T lymphocyte proliferation and normal cell cycle, reduced the DNA uracil content, and lowered the CD4(+) to CD8(+) ratio.	Nucleosides	10-20	CD8a molecule	Homo sapiens	182-185
15316562-2	2004	Pancreatic cancer cells treated with the nucleoside analogue gemcitabine (2", 2"-difluoro-2"deoxycytidine) showed increases in APE/redox effector factor (ref-1) protein levels (approximately two-fold for Panc-1 and six-fold for MiaPaCa-2), with corresponding increases in endonuclease activity.	Nucleosides	41-51	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	127-130
15316562-2	2004	Pancreatic cancer cells treated with the nucleoside analogue gemcitabine (2", 2"-difluoro-2"deoxycytidine) showed increases in APE/redox effector factor (ref-1) protein levels (approximately two-fold for Panc-1 and six-fold for MiaPaCa-2), with corresponding increases in endonuclease activity.	Nucleosides	41-51	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	154-159
15194733-1	2004	Human concentrative nucleoside transporter 1 (hCNT1) mediates active transport of nucleosides and anticancer and antiviral nucleoside drugs across cell membranes by coupling influx to the movement of Na(+) down its electrochemical gradient.	Nucleosides	82-93	solute carrier family 28 member 1	Homo sapiens	6-44
15254393-0	2004	Histone deacetylase inhibitor enhances the anti-leukemic activity of an established nucleoside analogue.	Nucleosides	84-94	histone deacetylase 9	Homo sapiens	0-19
15254393-4	2004	report that pre-treatment of human leukemic cells with a histone deacetylase inhibitor, MS-275 significantly enhances the abrogative capacity of an established nucleoside analogue, fludarabine.	Nucleosides	160-170	histone deacetylase 9	Homo sapiens	57-76
15246567-1	2004	tRNA-guanine transglycosylase (TGT) is an enzyme which synthesizes a modified nucleoside, queuosine, by exchanging the base moiety of guanosine for queuine in tRNA.	Nucleosides	78-88	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	0-29
15246567-1	2004	tRNA-guanine transglycosylase (TGT) is an enzyme which synthesizes a modified nucleoside, queuosine, by exchanging the base moiety of guanosine for queuine in tRNA.	Nucleosides	78-88	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	31-34
15246824-0	2004	Activation of c-Jun N-terminal kinase mediates gp120IIIB- and nucleoside analogue-induced sensory neuron toxicity.	Nucleosides	62-72	mitogen-activated protein kinase 8	Homo sapiens	14-37
15194733-1	2004	Human concentrative nucleoside transporter 1 (hCNT1) mediates active transport of nucleosides and anticancer and antiviral nucleoside drugs across cell membranes by coupling influx to the movement of Na(+) down its electrochemical gradient.	Nucleosides	82-93	solute carrier family 28 member 1	Homo sapiens	46-51
15240122-5	2004	This is in agreement with the observation that 5"-nucleotidase/deoxycytidine kinase ratio might be an important factor in predicting resistance to NAs.	Nucleosides	147-150	5'-nucleotidase ecto	Homo sapiens	47-62
15240122-5	2004	This is in agreement with the observation that 5"-nucleotidase/deoxycytidine kinase ratio might be an important factor in predicting resistance to NAs.	Nucleosides	147-150	deoxycytidine kinase	Homo sapiens	63-83
15183121-1	2004	Deoxycytidine kinase (dCK) is a key enzyme in the deoxynucleoside salvage pathway and in the activation of numerous nucleoside analogues used in cancer and antiviral chemotherapy.	Nucleosides	55-65	deoxycytidine kinase	Homo sapiens	0-20
15183121-10	2004	Activation of dCK by protein kinase inhibitors and OA was also observed in CCRF-CEM cells and in chronic lymphocytic leukemia B-lymphocytes, suggesting a general mechanism of post-translational regulation of dCK, which could be exploited to enhance the activation of antileukemic nucleoside analogues.	Nucleosides	280-290	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	14-17
15183121-1	2004	Deoxycytidine kinase (dCK) is a key enzyme in the deoxynucleoside salvage pathway and in the activation of numerous nucleoside analogues used in cancer and antiviral chemotherapy.	Nucleosides	55-65	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
15183121-10	2004	Activation of dCK by protein kinase inhibitors and OA was also observed in CCRF-CEM cells and in chronic lymphocytic leukemia B-lymphocytes, suggesting a general mechanism of post-translational regulation of dCK, which could be exploited to enhance the activation of antileukemic nucleoside analogues.	Nucleosides	280-290	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	208-211
15183121-3	2004	Here, we report the effects of a large panel of protein kinase inhibitors on dCK activity in the B-leukemia cell line EHEB, both in basal conditions and in the presence of the nucleoside analogue 2-chloro-2"-deoxyadenosine (CdA) which induces activation of dCK.	Nucleosides	176-186	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	77-80
15371014-3	2004	These transporters resemble their human counterparts hENT1 and hENT2 in exhibiting similar broad permeant specificities for nucleosides, while differing in their permeant selectivities for nucleobases.	Nucleosides	124-135	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	53-58
15205420-1	2004	Numerous bacteria and mammalian cells harbor two enzymes, phosphopentomutase (PPM) and 2-deoxyribose 5-phosphate aldolase (DERA), involved in the interconversion between nucleosides and central carbon metabolism.	Nucleosides	170-181	deoxyribose-phosphate aldolase	Homo sapiens	87-121
15205420-1	2004	Numerous bacteria and mammalian cells harbor two enzymes, phosphopentomutase (PPM) and 2-deoxyribose 5-phosphate aldolase (DERA), involved in the interconversion between nucleosides and central carbon metabolism.	Nucleosides	170-181	deoxyribose-phosphate aldolase	Homo sapiens	123-127
15371014-3	2004	These transporters resemble their human counterparts hENT1 and hENT2 in exhibiting similar broad permeant specificities for nucleosides, while differing in their permeant selectivities for nucleobases.	Nucleosides	124-135	solute carrier family 29 member 2	Homo sapiens	63-68
16120385-3	2004	These results demonstrate that the various NRTI nucleosides and nucleotides are capable, at sufficiently high concentrations, of directly affecting mitochondrial bioenergetics in vitro, which may enhance the toxicity observed in vivo previously attributed to inhibition of DNA polymerase-gamma.	Nucleosides	48-59	DNA polymerase gamma, catalytic subunit	Rattus norvegicus	273-293
15180459-8	2004	A comprehensive SAR investigation was performed based on additional chemical intervention to the quinolone template moiety, such as the introduction of nucleoside derivative functions.	Nucleosides	152-162	sarcosine dehydrogenase	Homo sapiens	16-19
15493835-1	2004	AIM: To investigate the inhibitory activity of salvianolic acid A (SAA) on nucleoside transport in cancer cells and its antitumor effect.	Nucleosides	75-85	serum amyloid A cluster	Mus musculus	67-70
15493835-11	2004	CONCLUSION: SAA is active in blocking nucleoside transport in cancer cells and potentiates the cytotoxicity of chemotherapeutic drugs.	Nucleosides	38-48	serum amyloid A cluster	Mus musculus	12-15
15205344-5	2004	We validated the positive correlation between SLC29A1 (nucleoside transporter ENT1) expression and potency of nucleoside analogues, azacytidine and inosine-glycodialdehyde.	Nucleosides	55-65	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	46-53
15205344-5	2004	We validated the positive correlation between SLC29A1 (nucleoside transporter ENT1) expression and potency of nucleoside analogues, azacytidine and inosine-glycodialdehyde.	Nucleosides	55-65	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	78-82
15138596-0	2004	Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice.	Nucleosides	68-79	beta-1,3-glucuronyltransferase 1	Homo sapiens	85-89
15138596-1	2004	To further provide scientific evidence before clinical application, the anti-tumor effects of apoptosis inducing nucleosides (AINs) released from CD57+HLA-DRbright natural suppressor (CD57.DR-NS) cell line on human gastric carcinoma (GCIY)-bearing severe combined immunodeficiency (SCID) mice were examined by monitoring tumor cell growth and change of body weight of mice.	Nucleosides	113-124	beta-1,3-glucuronyltransferase 1	Homo sapiens	146-150
15138596-1	2004	To further provide scientific evidence before clinical application, the anti-tumor effects of apoptosis inducing nucleosides (AINs) released from CD57+HLA-DRbright natural suppressor (CD57.DR-NS) cell line on human gastric carcinoma (GCIY)-bearing severe combined immunodeficiency (SCID) mice were examined by monitoring tumor cell growth and change of body weight of mice.	Nucleosides	113-124	beta-1,3-glucuronyltransferase 1	Homo sapiens	184-188
15139750-0	2004	Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors.	Nucleosides	44-54	adenosine deaminase	Rattus norvegicus	88-107
15059916-12	2004	They also provide insights into possible mechanisms by which novel, clinically relevant HDAC inhibitors might be used to enhance the antileukemic activity of established nucleoside analogues such as fludarabine.	Nucleosides	170-180	histone deacetylase 9	Homo sapiens	88-92
15150343-2	2004	We show that YadB is a tRNA modifying enzyme that evidently glutamylates the queuosine residue, a modified nucleoside at the wobble position of the tRNA(Asp) QUC anticodon.	Nucleosides	107-117	hypothetical protein	Escherichia coli	13-17
15319798-2	2004	Upon the availability of substrates, UPase can also catalyze the formation of nucleosides from uracil or 5-fluorouracil (5-FU) and ribose-1-phosphate (Rib-1-P).	Nucleosides	78-89	uridine phosphorylase 1	Homo sapiens	37-42
15139762-6	2004	Detailed studies demonstrated that the inhibitory effect against BChE is dependent on the nucleoside analogue, the substitution pattern of the cycloSal-moiety, and particularly on the stereochemistry at the phosphorus atom.	Nucleosides	90-100	butyrylcholinesterase	Homo sapiens	65-69
15064804-0	2004	Preparation and antiviral properties of new acyclic, achiral nucleoside analogues: 1- or 9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]nucleobases and 1- or 9-[2,3-dihydroxy-2-(hydroxymethyl)propyl]nucleobases.	Nucleosides	61-71	PROP paired-like homeobox 1	Homo sapiens	119-125
15064804-1	2004	Acyclic, achiral nucleoside derivatives 1b-e of adenine, cytosine, 5-methylcytosine, and guanine, containing a 3-hydroxy-2-(hydroxymethyl)prop-1-enyl group on N-1 or N-9, have been prepared analogously to the previously described thymine derivative 1a.	Nucleosides	17-27	PROP paired-like homeobox 1	Homo sapiens	138-144
15064375-4	2004	In the recombinant E. coli system, ZmHK1 and ZmHK3a were more sensitive to free-base cytokinins than to the corresponding nucleosides; isopentenyladenine was most effective for ZmHK1, while ZmHK2 tended to be most sensitive to trans-zeatin and the riboside.	Nucleosides	122-133	histidine kinase 1	Zea mays	35-40
15027876-4	2004	These hybrid *NO donor-nucleosides exhibited high cellular toxicity (CC(50) = 10(-6)-10(-8) M range) against a battery of tumor cell lines (143B-LTK, 143B, EMT-6, KBALB-STK, and KBALB) and normal human fibroblasts (Hs578Bst).	Nucleosides	23-34	leukocyte receptor tyrosine kinase	Homo sapiens	145-148
15064375-4	2004	In the recombinant E. coli system, ZmHK1 and ZmHK3a were more sensitive to free-base cytokinins than to the corresponding nucleosides; isopentenyladenine was most effective for ZmHK1, while ZmHK2 tended to be most sensitive to trans-zeatin and the riboside.	Nucleosides	122-133	histidine kinase 3	Zea mays	45-51
15009683-3	2004	Activation of AMPK by AICA riboside was greatly attenuated by inhibitors of equilibrative nucleoside transport.	Nucleosides	90-100	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	14-18
15013762-3	2004	The transporter CNT2 for nucleosides was upregulated between 6 and 18 h after challenge, whereas the level of GLUT1 transporter for glucose became elevated at 6 h. Both changes probably facilitate uptake of these nutrients in the gut.	Nucleosides	25-36	solute carrier family 28 member 2	Rattus norvegicus	16-20
15104248-1	2004	Deoxycytidine kinase (dCK), the principal deoxynucleoside salvage enzyme, plays a seminal role in the bioactivation of a wide array of cytotoxic nucleoside analogues.	Nucleosides	47-57	deoxycytidine kinase	Homo sapiens	0-20
15104248-1	2004	Deoxycytidine kinase (dCK), the principal deoxynucleoside salvage enzyme, plays a seminal role in the bioactivation of a wide array of cytotoxic nucleoside analogues.	Nucleosides	47-57	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
14737075-5	2004	Furthermore, selected members of the expanding ATP-binding cassette (ABC) protein family have recently been identified as putative efflux pumps for the phosphorylated forms of these nucleoside-derived drugs, ABCC11 (MRP8) being a good candidate to modulate cell sensitivity to fluoropyrimidines.	Nucleosides	182-192	ATP binding cassette subfamily C member 11	Homo sapiens	208-214
14737075-5	2004	Furthermore, selected members of the expanding ATP-binding cassette (ABC) protein family have recently been identified as putative efflux pumps for the phosphorylated forms of these nucleoside-derived drugs, ABCC11 (MRP8) being a good candidate to modulate cell sensitivity to fluoropyrimidines.	Nucleosides	182-192	ATP binding cassette subfamily C member 11	Homo sapiens	216-220
14978234-3	2004	To define the relative and unified structural requirements of nucleoside analogs for interaction with hCNT1, hCNT2, and hENT1, we applied an array of structure-activity techniques.	Nucleosides	62-72	solute carrier family 28 member 1	Homo sapiens	102-107
14978234-3	2004	To define the relative and unified structural requirements of nucleoside analogs for interaction with hCNT1, hCNT2, and hENT1, we applied an array of structure-activity techniques.	Nucleosides	62-72	solute carrier family 28 member 2	Homo sapiens	109-114
14978229-1	2004	The concentrative nucleoside transporter, CNT1 (SLC28A1), mediates the cellular uptake of naturally occurring pyrimidine nucleosides and many structurally diverse anticancer and antiviral nucleoside analogs.	Nucleosides	18-28	solute carrier family 28 member 1	Homo sapiens	42-46
14978229-1	2004	The concentrative nucleoside transporter, CNT1 (SLC28A1), mediates the cellular uptake of naturally occurring pyrimidine nucleosides and many structurally diverse anticancer and antiviral nucleoside analogs.	Nucleosides	18-28	solute carrier family 28 member 1	Homo sapiens	48-55
14978234-3	2004	To define the relative and unified structural requirements of nucleoside analogs for interaction with hCNT1, hCNT2, and hENT1, we applied an array of structure-activity techniques.	Nucleosides	62-72	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	120-125
14978229-8	2004	The anticancer nucleoside analog gemcitabine had a reduced affinity for CNT1-Val189Ile (a common CNT1 variant found at a frequency of 26%) compared with reference CNT1 (IC50=13.8 +/- 0.60 microM for CNT1-reference and 23.3 +/- 1.5 microM for CNT1-Val189Ile, p<0.05).	Nucleosides	15-25	solute carrier family 28 member 1	Homo sapiens	72-76
14978229-8	2004	The anticancer nucleoside analog gemcitabine had a reduced affinity for CNT1-Val189Ile (a common CNT1 variant found at a frequency of 26%) compared with reference CNT1 (IC50=13.8 +/- 0.60 microM for CNT1-reference and 23.3 +/- 1.5 microM for CNT1-Val189Ile, p<0.05).	Nucleosides	15-25	solute carrier family 28 member 1	Homo sapiens	97-101
14973255-5	2004	In this report we show that the G1 phase-specific expression of the replication factor Mcm2 is a useful marker for detecting slowly cycling putative NSCs in situ and confirm the identity of these cells using both cytosine beta-D-arabinofuranoside (Ara-C) treatment and a double nucleoside analog-labeling technique.	Nucleosides	278-288	minichromosome maintenance complex component 2	Mus musculus	87-91
14978229-8	2004	The anticancer nucleoside analog gemcitabine had a reduced affinity for CNT1-Val189Ile (a common CNT1 variant found at a frequency of 26%) compared with reference CNT1 (IC50=13.8 +/- 0.60 microM for CNT1-reference and 23.3 +/- 1.5 microM for CNT1-Val189Ile, p<0.05).	Nucleosides	15-25	solute carrier family 28 member 1	Homo sapiens	97-101
14978229-8	2004	The anticancer nucleoside analog gemcitabine had a reduced affinity for CNT1-Val189Ile (a common CNT1 variant found at a frequency of 26%) compared with reference CNT1 (IC50=13.8 +/- 0.60 microM for CNT1-reference and 23.3 +/- 1.5 microM for CNT1-Val189Ile, p<0.05).	Nucleosides	15-25	solute carrier family 28 member 1	Homo sapiens	97-101
14978229-8	2004	The anticancer nucleoside analog gemcitabine had a reduced affinity for CNT1-Val189Ile (a common CNT1 variant found at a frequency of 26%) compared with reference CNT1 (IC50=13.8 +/- 0.60 microM for CNT1-reference and 23.3 +/- 1.5 microM for CNT1-Val189Ile, p<0.05).	Nucleosides	15-25	solute carrier family 28 member 1	Homo sapiens	97-101
14978229-9	2004	These data suggest that common genetic variants of CNT1 may contribute to variation in systemic and intracellular levels of anti-cancer nucleoside analogs.	Nucleosides	136-146	solute carrier family 28 member 1	Homo sapiens	51-55
15832508-2	2004	The substrate specificity of BPHL was investigated with a series of amino acid ester prodrugs of the therapeutic nucleoside analogues: acyclovir, zidovudine, floxuridine, 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl) benzimidazole, and gemcitabine.	Nucleosides	113-123	biphenyl hydrolase like	Homo sapiens	29-33
15832508-4	2004	The results indicate that the substrate specificity of BPHL is largely determined by the amino acid acyl promoiety, and is less sensitive to the nucleoside parent drugs.	Nucleosides	145-155	biphenyl hydrolase like	Homo sapiens	55-59
15832508-5	2004	For all nucleoside parent drugs, BPHL preferred the hydrophobic amino acids valine, phenylalanine, and proline over the charged amino acids lysine and aspartic acid.	Nucleosides	8-18	biphenyl hydrolase like	Homo sapiens	33-37
15832508-9	2004	The substrate specificity suggests that the substrate-binding pocket of BPHL has a hydrophobic acyl binding site which can accommodate the positively charged alpha-amino group, while having an alcohol leaving group binding site that can accommodate nucleoside analogues with a relatively generous spatial allowance.	Nucleosides	249-259	biphenyl hydrolase like	Homo sapiens	72-76
15832508-10	2004	In conclusion, BPHL catalyzes the hydrolytic activation of amino acid esters of a broad range of therapeutic nucleoside analogues in addition to valacyclovir and valganciclovir and has considerable potential for utilization as an activation target for design of antiviral and anticancer nucleoside analogue prodrugs.	Nucleosides	109-119	biphenyl hydrolase like	Homo sapiens	15-19
15832508-10	2004	In conclusion, BPHL catalyzes the hydrolytic activation of amino acid esters of a broad range of therapeutic nucleoside analogues in addition to valacyclovir and valganciclovir and has considerable potential for utilization as an activation target for design of antiviral and anticancer nucleoside analogue prodrugs.	Nucleosides	287-297	biphenyl hydrolase like	Homo sapiens	15-19
14757392-3	2004	RESULTS: Nucleosides enhanced fibronectin, laminin, and alpha1(I) procollagen levels in CFSC-2G and hepatocytes, as well as collagen synthesis and secretion in CFSC-2G.	Nucleosides	9-20	fibronectin 1	Rattus norvegicus	30-41
14725971-1	2004	The influence of a nucleoside analog 5-aza-2"-deoxycytidine (5-AzadC) on inducible nitric oxide synthase (iNOS)-dependent nitric oxide (NO) production in various rat cell types was investigated.	Nucleosides	19-29	nitric oxide synthase 2	Rattus norvegicus	73-104
14725971-1	2004	The influence of a nucleoside analog 5-aza-2"-deoxycytidine (5-AzadC) on inducible nitric oxide synthase (iNOS)-dependent nitric oxide (NO) production in various rat cell types was investigated.	Nucleosides	19-29	nitric oxide synthase 2	Rattus norvegicus	106-110
14738456-1	2004	This study tested the hypothesis that in patients with HIV-associated lipodystrophy, adiponectin levels were related to insulin resistance, TNF-alpha and IL-6 and treatment with nucleoside analogues.	Nucleosides	178-188	adiponectin, C1Q and collagen domain containing	Homo sapiens	85-96
15037197-0	2004	Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep.	Nucleosides	33-43	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	57-62
15037197-2	2004	hENT1 is ubiquitously expressed and plays an important role in the disposition and pharmacological activity of nucleoside drugs and nucleosides, such as adenosine.	Nucleosides	111-121	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	0-5
15037197-2	2004	hENT1 is ubiquitously expressed and plays an important role in the disposition and pharmacological activity of nucleoside drugs and nucleosides, such as adenosine.	Nucleosides	132-143	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	0-5
15037197-4	2004	hENT1 and hENT2 differ in their affinity for nucleoside substrates and in their sensitivity to inhibitors, such as nitrobenzylthioinosine (NBMPR).	Nucleosides	45-55	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	0-5
15037197-4	2004	hENT1 and hENT2 differ in their affinity for nucleoside substrates and in their sensitivity to inhibitors, such as nitrobenzylthioinosine (NBMPR).	Nucleosides	45-55	solute carrier family 29 member 2	Homo sapiens	10-15
15037197-5	2004	hENT1 has higher (or equal) affinity to hENT2 for all natural nucleosides except inosine.	Nucleosides	62-73	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	0-5
15037197-5	2004	hENT1 has higher (or equal) affinity to hENT2 for all natural nucleosides except inosine.	Nucleosides	62-73	solute carrier family 29 member 2	Homo sapiens	40-45
14965358-8	2004	Although both nucleosides are phosphorylated by deoxycytidine kinase and are also good substrates of cytidine deaminase, only gemcitabine shows antitumor activity against solid tumors.	Nucleosides	14-25	cytidine deaminase	Homo sapiens	101-119
14757392-4	2004	In contrast, nucleosides lowered fibronectin, laminin and alpha1(I) procollagen levels, and decreased collagen synthesis in co-cultures.	Nucleosides	13-24	fibronectin 1	Rattus norvegicus	33-44
14757392-5	2004	Matrix metalloproteinase-13 content and collagen secretion increased in co-cultures incubated with nucleosides.	Nucleosides	99-110	matrix metallopeptidase 13	Rattus norvegicus	0-27
12856181-1	2004	The SLC28 family consists of three subtypes of sodium-dependent, concentrative nucleoside transporters, CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3, respectively), that transport both naturally occurring nucleosides and synthetic nucleoside analogs used in the treatment of various diseases.	Nucleosides	212-223	solute carrier family 28 member 3	Homo sapiens	120-124
14977407-5	2004	The structural similarity of a variety of drugs with the basic structure of di- or tripeptides explains the transport of aminocephalosporins and aminopenicillins, selected angiotensin-converting inhibitors, and amino acid-conjugated nucleoside-based antiviral agents by PEPT1.	Nucleosides	233-243	solute carrier family 15 member 1	Homo sapiens	270-275
12856181-1	2004	The SLC28 family consists of three subtypes of sodium-dependent, concentrative nucleoside transporters, CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3, respectively), that transport both naturally occurring nucleosides and synthetic nucleoside analogs used in the treatment of various diseases.	Nucleosides	212-223	solute carrier family 28 member 1	Homo sapiens	104-108
15244247-1	2004	OGT 719 (Oxford GlycoSciences, Abingdon, UK) is a novel nucleoside analogue with a galactose molecule attached to a fluorinated pyrimidine.	Nucleosides	56-66	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	0-3
15043160-1	2004	The sugar moiety of nucleosides has been shown to play a major role in permeant-transporter interaction with human equilibrative nucleoside transporters 1 and 2 (hENT1 and hENT2).	Nucleosides	20-31	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	115-160
15612613-1	2004	The novel cytotoxic nucleoside analog Compound 003 (3"-azidothymidine 5"-[p-methoxyphenyl methoxyalaninyl phosphate], CAS 149560-32-7) prevented bipolar mitotic spindle assembly and caused a G2 arrest in human cancer cells.	Nucleosides	20-30	BCAR1 scaffold protein, Cas family member	Homo sapiens	118-121
14766427-1	2004	Extracellular purine nucleotide and nucleoside signalling molecules, such as ATP and adenosine, acting through specific receptors (P2 and P1, respectively) play significant roles in the mechanisms underlying the febrile response.	Nucleosides	36-46	neuropeptide Y receptor Y4	Homo sapiens	131-140
15520873-0	2004	[Special function of deoxycytidine kinase (dCK) in the activation of chemotherapeutic nucleoside analogs and in the inhibition of cell proliferation].	Nucleosides	86-96	deoxycytidine kinase	Homo sapiens	21-41
15520873-0	2004	[Special function of deoxycytidine kinase (dCK) in the activation of chemotherapeutic nucleoside analogs and in the inhibition of cell proliferation].	Nucleosides	86-96	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	43-46
15520873-6	2004	In contrast to this, dCK activity was found to be elevated several fold upon short-term treatments of normal human lymphocytes with therapeutic nucleoside analogs, and other genotoxic agents as well as by DNA damaging agents including the DNA polymerase inhibitor aphidicolin, the topoisomerase II inhibitor etoposide and gamma-irradiation, which might be a potentially important phenomenon with respect to the clinical practice, too.	Nucleosides	144-154	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	21-24
15043146-5	2004	The methodologies are general and allow ready access to a variety of C-5 functionalized isomeric deoxyuridines, but also have the potential to be extended to other nucleoside analogs.	Nucleosides	164-174	complement C5	Homo sapiens	69-72
14727918-6	2004	The relative efficacy of adduct formation was G > T > A >> C. The four DNA nucleosides were also reacted with the dihalomethanes CH(2)Cl(2) and CH(2)Br(2) in the presence of glutathione (GSH) and GSH S-transferases from bacteria (DM11), rat (GST 5-5), and human (GST T1-1) under conditions that produce mutations in bacteria.	Nucleosides	87-98	glutathione S-transferase theta 1	Rattus norvegicus	254-261
14727918-6	2004	The relative efficacy of adduct formation was G > T > A >> C. The four DNA nucleosides were also reacted with the dihalomethanes CH(2)Cl(2) and CH(2)Br(2) in the presence of glutathione (GSH) and GSH S-transferases from bacteria (DM11), rat (GST 5-5), and human (GST T1-1) under conditions that produce mutations in bacteria.	Nucleosides	87-98	CD2 molecule	Homo sapiens	279-283
15043160-1	2004	The sugar moiety of nucleosides has been shown to play a major role in permeant-transporter interaction with human equilibrative nucleoside transporters 1 and 2 (hENT1 and hENT2).	Nucleosides	20-31	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	162-167
15452377-3	2004	We have therefore performed a retrospective analysis of t(11;18)(q21;q21) in patients undergoing chemotherapy with the nucleoside analogue cladribine (2CdA) for gastric MALT lymphoma.	Nucleosides	119-129	cytidine deaminase	Homo sapiens	152-155
15043160-1	2004	The sugar moiety of nucleosides has been shown to play a major role in permeant-transporter interaction with human equilibrative nucleoside transporters 1 and 2 (hENT1 and hENT2).	Nucleosides	20-31	solute carrier family 29 member 2	Homo sapiens	172-177
14645682-9	2003	The binding profiles identified in this study can be used to predict the potential transportability of nucleoside analogs, including anticancer or antiviral nucleoside drugs, by hCNT1 and hCNT3.	Nucleosides	103-113	solute carrier family 28 member 1	Homo sapiens	178-183
14689214-6	2004	The IL-2 level of the NS/NT free group was significantly lower than that of the NS/NT supplemented group.	Nucleosides	22-24	interleukin 2	Rattus norvegicus	4-8
14689214-6	2004	The IL-2 level of the NS/NT free group was significantly lower than that of the NS/NT supplemented group.	Nucleosides	80-82	interleukin 2	Rattus norvegicus	4-8
14689214-9	2004	The NS/NT free diet is therefore considered to have an immunosuppressive effect on rat allogenic small intestinal transplantation based on the recipient plasma IL-2 levels and the histological findings of the grafts.	Nucleosides	4-6	interleukin 2	Rattus norvegicus	160-164
14680831-1	2003	Purine nucleoside phosphorylase (PNP) catalyzes the phosphorolysis of the N-ribosidic bonds of purine nucleosides and deoxynucleosides.	Nucleosides	102-113	purine nucleoside phosphorylase	Homo sapiens	0-31
14680831-1	2003	Purine nucleoside phosphorylase (PNP) catalyzes the phosphorolysis of the N-ribosidic bonds of purine nucleosides and deoxynucleosides.	Nucleosides	102-113	purine nucleoside phosphorylase	Homo sapiens	33-36
14645682-9	2003	The binding profiles identified in this study can be used to predict the potential transportability of nucleoside analogs, including anticancer or antiviral nucleoside drugs, by hCNT1 and hCNT3.	Nucleosides	103-113	solute carrier family 28 member 3	Homo sapiens	188-193
14575494-1	2003	The concept of spirocyclic restriction, when generically applied to nucleoside mimics, allows for the preparation of diastereomeric pairs carrying either a syn- or anti-oriented hydroxyl at C-5".	Nucleosides	68-78	synemin	Homo sapiens	156-159
12868960-0	2003	Interferon-gamma regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways.	Nucleosides	27-37	interferon gamma	Mus musculus	0-16
12868960-0	2003	Interferon-gamma regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways.	Nucleosides	27-37	signal transducer and activator of transcription 1	Mus musculus	79-137
12868960-0	2003	Interferon-gamma regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways.	Nucleosides	27-37	signal transducer and activator of transcription 1	Mus musculus	139-144
12868960-6	2003	Interestingly, IFN-gamma led to an induction of the CNT1- and CNT2-related nucleoside transport activities independent of STAT1, thus ensuring the supply of extracellular nucleosides for the STAT1-independent RNA synthesis.	Nucleosides	75-85	interferon gamma	Mus musculus	15-24
12868960-6	2003	Interestingly, IFN-gamma led to an induction of the CNT1- and CNT2-related nucleoside transport activities independent of STAT1, thus ensuring the supply of extracellular nucleosides for the STAT1-independent RNA synthesis.	Nucleosides	75-85	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	Mus musculus	52-56
12868960-6	2003	Interestingly, IFN-gamma led to an induction of the CNT1- and CNT2-related nucleoside transport activities independent of STAT1, thus ensuring the supply of extracellular nucleosides for the STAT1-independent RNA synthesis.	Nucleosides	75-85	solute carrier family 28 (sodium-coupled nucleoside transporter), member 2	Mus musculus	62-66
12868960-6	2003	Interestingly, IFN-gamma led to an induction of the CNT1- and CNT2-related nucleoside transport activities independent of STAT1, thus ensuring the supply of extracellular nucleosides for the STAT1-independent RNA synthesis.	Nucleosides	75-85	signal transducer and activator of transcription 1	Mus musculus	191-196
12868960-6	2003	Interestingly, IFN-gamma led to an induction of the CNT1- and CNT2-related nucleoside transport activities independent of STAT1, thus ensuring the supply of extracellular nucleosides for the STAT1-independent RNA synthesis.	Nucleosides	171-182	interferon gamma	Mus musculus	15-24
12868960-6	2003	Interestingly, IFN-gamma led to an induction of the CNT1- and CNT2-related nucleoside transport activities independent of STAT1, thus ensuring the supply of extracellular nucleosides for the STAT1-independent RNA synthesis.	Nucleosides	171-182	solute carrier family 28 (sodium-coupled nucleoside transporter), member 1	Mus musculus	52-56
12868960-6	2003	Interestingly, IFN-gamma led to an induction of the CNT1- and CNT2-related nucleoside transport activities independent of STAT1, thus ensuring the supply of extracellular nucleosides for the STAT1-independent RNA synthesis.	Nucleosides	171-182	solute carrier family 28 (sodium-coupled nucleoside transporter), member 2	Mus musculus	62-66
12868960-6	2003	Interestingly, IFN-gamma led to an induction of the CNT1- and CNT2-related nucleoside transport activities independent of STAT1, thus ensuring the supply of extracellular nucleosides for the STAT1-independent RNA synthesis.	Nucleosides	171-182	signal transducer and activator of transcription 1	Mus musculus	191-196
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	114-125	solute carrier family 28 member 1	Homo sapiens	166-170
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	114-125	solute carrier family 28 member 3	Homo sapiens	171-175
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	114-125	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	306-310
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	114-125	solute carrier family 29 member 2	Homo sapiens	311-315
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	114-125	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	317-324
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	114-125	solute carrier family 29 member 2	Homo sapiens	325-332
14531805-5	2003	To demonstrate the role of fibroblasts in PFS, we treated these FSP1.Delta tk mice with a nucleoside analogue to induce DNA chain termination and fibroblast death.	Nucleosides	90-100	S100 calcium binding protein A4	Mus musculus	64-68
14531805-9	2003	Treatment of PFS in FSP1.Delta tk transgenic mice with a nucleoside analogue selectively reduced the numbers of peritoneal fibroblasts and attenuated the attendant changes in peritoneal histology.	Nucleosides	57-67	S100 calcium binding protein A4	Mus musculus	20-24
14504928-2	2003	Previous expression studies in oocytes showed that the Km values for nucleosides of the cloned hCNT3 were 7- to 25-fold lower than the endogenous N3 transporter in HL60 cells.	Nucleosides	69-80	solute carrier family 28 member 3	Homo sapiens	95-100
14504928-4	2003	We demonstrated that hCNT3 is a Na-dependent, broadly-selective nucleoside transporter with affinities (<11 microM) for nucleosides closely resembling the endogenous N3 transporter.	Nucleosides	123-134	solute carrier family 28 member 3	Homo sapiens	21-26
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	250-261	solute carrier family 28 member 1	Homo sapiens	166-170
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	250-261	solute carrier family 28 member 3	Homo sapiens	171-175
14561097-0	2003	Potent inhibition of NTPase/helicase of the West Nile Virus by ring-expanded ("fat") nucleoside analogues.	Nucleosides	85-95	inosine triphosphatase	Homo sapiens	21-27
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	250-261	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	306-310
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	250-261	solute carrier family 29 member 2	Homo sapiens	311-315
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	250-261	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	317-324
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	250-261	solute carrier family 29 member 2	Homo sapiens	325-332
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	250-261	solute carrier family 28 member 1	Homo sapiens	166-170
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	250-261	solute carrier family 28 member 3	Homo sapiens	171-175
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	250-261	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	306-310
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	250-261	solute carrier family 29 member 2	Homo sapiens	311-315
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	250-261	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	317-324
14612157-2	2003	There are five known, functionally characterized nucleoside transporters with varying substrate specificities for nucleosides: concentrative nucleoside transporters (CNT1-CNT3; Solute Carrier (SLC) 28A1-28A3), which mediate the intracellular flux of nucleosides, and equilibrative nucleoside transporters (ENT1-ENT2; SLC29A1-SLC29A2), which mediate bi-directional facilitated diffusion of nucleosides.	Nucleosides	250-261	solute carrier family 29 member 2	Homo sapiens	325-332
14561097-0	2003	Potent inhibition of NTPase/helicase of the West Nile Virus by ring-expanded ("fat") nucleoside analogues.	Nucleosides	85-95	helicase for meiosis 1	Homo sapiens	28-36
12952466-9	2003	2,6-Diaminopurine ribonucleoside in RNA is not a substrate for ADAR, in contrast to adenosine deaminase (ADA), which catalyzes a similar reaction on nucleosides.	Nucleosides	149-160	adenosine deaminase	Homo sapiens	84-103
12925971-3	2003	A common nucleoside resistance mechanism is mutation affecting the expression or the specificity of dCK.	Nucleosides	9-19	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	100-103
12810710-15	2003	Adenosine and uridine transport by AtENT3, although partly sensitive to the vasodilator drugs dilazep and dipyridamole, was resistant to the nucleoside analogue nitrobenzylmercaptopurine ribonucleoside.	Nucleosides	141-151	Major facilitator superfamily protein	Arabidopsis thaliana	35-41
12869561-9	2003	In addition, A-ODNs specific for Hsp60 also inhibit replication of a mutant HBV strain that is resistant to the nucleoside analogue 3TC, which is the main drug used for HBV treatment, and we suggest that A-ODNs directed against Hsp60 are possible reagents as anti-HBV drugs.	Nucleosides	112-122	heat shock protein family D (Hsp60) member 1	Homo sapiens	33-38
12952466-11	2003	Consistent with the large 8-aza effect observed for the ADAR2 reaction, we find that 8-azanebularine, as the free nucleoside, inhibits the ADAR2 reaction (IC(50) = 15 +/- 3 mM) with no inhibition observed with nebularine or coformycin.	Nucleosides	114-124	adenosine deaminase RNA specific B1	Homo sapiens	139-144
12914785-1	2003	Purine nucleoside phosphorylase (PNP) catalyzes the phosphorolysis of the N-ribosidic bonds of purine nucleosides and deoxynucleosides.	Nucleosides	102-113	purine nucleoside phosphorylase	Homo sapiens	0-31
12960196-2	2003	FLT is a nucleoside analog that enters cells and is phosphorylated by human thymidine kinase 1, but the 3" substitution prevents further incorporation into DNA.	Nucleosides	9-19	fms related receptor tyrosine kinase 1	Homo sapiens	0-3
12960196-2	2003	FLT is a nucleoside analog that enters cells and is phosphorylated by human thymidine kinase 1, but the 3" substitution prevents further incorporation into DNA.	Nucleosides	9-19	thymidine kinase 1	Homo sapiens	76-94
12930387-1	2003	The purine nucleoside analogue 2-chlorodeoxyadenosine (2-CdA) is currently considered by many as first-line therapy for hairy cell leukaemia.	Nucleosides	11-21	cytidine deaminase	Homo sapiens	57-60
12914785-1	2003	Purine nucleoside phosphorylase (PNP) catalyzes the phosphorolysis of the N-ribosidic bonds of purine nucleosides and deoxynucleosides.	Nucleosides	102-113	purine nucleoside phosphorylase	Homo sapiens	33-36
12893280-12	2003	This suggests that hCNT2 (and rCNT2) may have a significant role in uptake of nucleoside drugs from the intestine and is a potential transporter target for the development of nucleoside and nucleoside-mimetic drugs.	Nucleosides	78-88	solute carrier family 28 member 2	Homo sapiens	19-24
12930144-7	2003	Although the 5"-O-phosphorylated compounds have somewhat higher affinities for the enzyme, the parent nucleosides generally exhibit affinities for TMPKmt in the same order of magnitude and display a superior selectivity profile versus human TMPK.	Nucleosides	102-113	deoxythymidylate kinase	Homo sapiens	147-151
12907246-5	2003	We investigated the dephosphorylation of the 5"-phosphates of commonly used nucleoside analogs by two cytosolic (cN-II and dNT-1) and one mitochondrial (dNT-2) nucleotidase.	Nucleosides	76-86	5'-nucleotidase, cytosolic II	Homo sapiens	113-118
12893280-12	2003	This suggests that hCNT2 (and rCNT2) may have a significant role in uptake of nucleoside drugs from the intestine and is a potential transporter target for the development of nucleoside and nucleoside-mimetic drugs.	Nucleosides	78-88	solute carrier family 28 member 2	Rattus norvegicus	30-35
12907246-5	2003	We investigated the dephosphorylation of the 5"-phosphates of commonly used nucleoside analogs by two cytosolic (cN-II and dNT-1) and one mitochondrial (dNT-2) nucleotidase.	Nucleosides	76-86	Neurotrophin 1	Drosophila melanogaster	123-128
12792795-0	2003	Effects of apoptosis-inducing nucleosides released from CD57+HLA-DRbright natural suppressor cell line on human breast cancer cell death and growth.	Nucleosides	30-41	beta-1,3-glucuronyltransferase 1	Homo sapiens	56-60
12907246-5	2003	We investigated the dephosphorylation of the 5"-phosphates of commonly used nucleoside analogs by two cytosolic (cN-II and dNT-1) and one mitochondrial (dNT-2) nucleotidase.	Nucleosides	76-86	spatzle 5	Drosophila melanogaster	153-158
12823558-2	2003	Dm-dNK phosphorylates both purine and pyrimidine deoxyribonucleosides and nucleoside analogues although it has a preference for pyrimidine nucleosides.	Nucleosides	58-68	deoxyribonucleoside kinase	Drosophila melanogaster	0-6
12880607-6	2003	RESULTS: The exogenous nucleosides increased the intracellular concentrations of UTP, UDP-glucose, CDP-choline and NAD(+), in the single cultures of CFSC-2G and hepatocytes.	Nucleosides	23-34	cut like homeobox 1	Homo sapiens	99-102
12876298-0	2003	Prolactin, cortisol, and insulin regulation of nucleoside uptake into mouse mammary gland explants.	Nucleosides	47-57	prolactin	Mus musculus	0-9
12792795-1	2003	The CD57+HLA-DRbright-natural suppressor (57.DR-NS) cell line induced apoptosis in estrogen-non-responsive human breast carcinoma MDA-MB-435 cells by apoptosis-inducing nucleosides (AINs) released into the cultures.	Nucleosides	169-180	beta-1,3-glucuronyltransferase 1	Homo sapiens	4-8
12829811-1	2003	The human cytomegalovirus UL97 protein is an unusual protein kinase that is able to autophosphorylate and to phosphorylate certain exogenous substrates, including nucleoside analogs such as ganciclovir.	Nucleosides	163-173	tegument serine/threonine protein kinase	Human betaherpesvirus 5	26-30
12916010-13	2003	CONCLUSION: A regime of nevirapine with two nucleoside analogues provided durable suppression of plasma viral load in HIV infected patients, with significant improvement in the CD4 cell count.	Nucleosides	44-54	CD4 molecule	Homo sapiens	177-180
12808445-1	2003	Human deoxycytidine kinase (dCK) phosphorylates the natural deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) and is an essential enzyme for the phosphorylation of numerous nucleoside analog prodrugs routinely used in cancer and antiviral chemotherapy.	Nucleosides	69-79	deoxycytidine kinase	Homo sapiens	6-26
12916861-10	2003	The observation that cytosolic cN-II is able to phosphorylate purine nucleosides has initiated studies on its potential participation in the metabolism of anticancer agents and in the development of cN-II inhibitory substances.	Nucleosides	69-80	5'-nucleotidase, cytosolic II	Homo sapiens	31-36
12808445-1	2003	Human deoxycytidine kinase (dCK) phosphorylates the natural deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA) and is an essential enzyme for the phosphorylation of numerous nucleoside analog prodrugs routinely used in cancer and antiviral chemotherapy.	Nucleosides	69-79	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	28-31
12730608-5	2003	First, it was determined if compounds that influenced AsV reduction by purified PNP (i.e., nucleosides, thiols, and PNP inhibitors) would similarly affect reduction of AsV by human erythrocytes.	Nucleosides	91-102	purine nucleoside phosphorylase	Homo sapiens	80-83
12781179-1	2003	A series of shape-modified flexible nucleosides ("fleximers", 1, 2, and 3) was modeled, synthesized and subsequently assayed against S-adenosyl-L-homocysteine hydrolase (SAHase).	Nucleosides	36-47	adenosylhomocysteinase	Homo sapiens	170-176
12527552-11	2003	These data suggest that hENT1 and hENT2 on the basolateral membrane function with concentrative nucleoside transporters on the apical membrane to mediate active reabsorption of nucleosides within the kidney.	Nucleosides	177-188	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	24-29
12660303-2	2003	In this study, their contribution to the renal uptake of organic anions and nucleoside derivatives was examined by investigating the uptake by rOat1- and rOat3-expressing cells and kidney slices.	Nucleosides	76-86	solute carrier family 22 member 6	Rattus norvegicus	143-148
12624104-5	2003	APE1 showed a similar K(m) value for matched, 3" mispaired, or nucleoside analog beta-l-dioxolane-cytidine terminated nicked DNA as well as for DNA containing a tetrahydrofuran, an abasic site analog.	Nucleosides	63-73	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	0-4
12527552-11	2003	These data suggest that hENT1 and hENT2 on the basolateral membrane function with concentrative nucleoside transporters on the apical membrane to mediate active reabsorption of nucleosides within the kidney.	Nucleosides	177-188	solute carrier family 29 member 2	Homo sapiens	34-39
12699351-2	2003	These nucleosides are transported into tumor cells via specific nucleoside transporters (NT), and then phosphorylated toward each monophosphate form by dCyd kinase.	Nucleosides	6-17	Cyd	Drosophila melanogaster	152-156
12695538-0	2003	Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5.	Nucleosides	37-47	ATP binding cassette subfamily C member 4	Homo sapiens	104-108
12694532-4	2003	Since caffeine is a derivative of xanthine, the bases and nucleosides were screened for their ability to inhibit RCC1.	Nucleosides	58-69	regulator of chromosome condensation	Mesocricetus auratus	113-117
12695538-9	2003	Cellular efflux and vesicular uptake studies were carried out to further compare transport mediated by MRP4 and MRP5 and showed that dipyridamole, dilazep, nitrobenzyl mercaptopurine riboside, sildenafil, trequinsin and MK571 inhibited MRP4 more than MRP5, whereas cyclic nucleotides and monophosphorylated nucleoside analogs were equally poor inhibitors of both pumps.	Nucleosides	307-317	ATP binding cassette subfamily C member 4	Homo sapiens	103-107
12695538-0	2003	Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5.	Nucleosides	37-47	ATP binding cassette subfamily C member 5	Homo sapiens	113-117
12682365-2	2003	In yeast, the formation of this modified nucleoside is catalyzed by the essential tRNA (m1A58) methyltransferase, a tetrameric enzyme that is composed of two types of subunits (Gcd14p and Gcd10p).	Nucleosides	41-51	tRNA 1-methyladenosine methyltransferase subunit GCD14	Saccharomyces cerevisiae S288C	177-183
12724623-1	2003	The human equilibrative nucleoside transporter, ENT1, appears to play a critical role in the disposition of nucleosides and nucleoside analogs used clinically as anti-viral and anti-cancer drugs.	Nucleosides	108-119	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	48-52
12724623-1	2003	The human equilibrative nucleoside transporter, ENT1, appears to play a critical role in the disposition of nucleosides and nucleoside analogs used clinically as anti-viral and anti-cancer drugs.	Nucleosides	24-34	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	48-52
12682365-2	2003	In yeast, the formation of this modified nucleoside is catalyzed by the essential tRNA (m1A58) methyltransferase, a tetrameric enzyme that is composed of two types of subunits (Gcd14p and Gcd10p).	Nucleosides	41-51	tRNA 1-methyladenosine methyltransferase subunit GCD10	Saccharomyces cerevisiae S288C	188-194
12475744-11	2003	Finally, in KO mice, volume-sensitive Cl(-) currents are potentially functional, but the absence of CFTR precludes their activation by extracellular nucleosides.	Nucleosides	149-160	cystic fibrosis transmembrane conductance regulator	Mus musculus	100-104
12523936-1	2003	Human multidrug-resistance protein (MRP) 4 transports cyclic nucleotides and when overproduced in mammalian cells mediates resistance to some nucleoside analogues.	Nucleosides	142-152	ATP binding cassette subfamily C member 4	Homo sapiens	6-42
12406882-7	2003	In both the primary tumor cells from our patient and PEL cell lines, AZT selectively blocked nuclear entry of the NF-kappaB heterodimer p50 and p65, an effect not seen with other nonthymidine antiviral nucleosides.	Nucleosides	202-213	nuclear factor kappa B subunit 1	Homo sapiens	114-123
12654739-1	2003	OBJECTIVES: Given that the guanosine-quadruplex may have a role in blocking the interaction between gp120 and CD4, we describe here the design of a highly nuclease-resistant dimeric hairpin guanosine-quadruplex, [Gm3Um4Gm3-s], containing the 2"-O-methyl groups on the nucleoside and sulphur groups on the internucleotidic bonds, and its anti-HIV-1 activity in cultured cells.	Nucleosides	268-278	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	100-105
12654739-1	2003	OBJECTIVES: Given that the guanosine-quadruplex may have a role in blocking the interaction between gp120 and CD4, we describe here the design of a highly nuclease-resistant dimeric hairpin guanosine-quadruplex, [Gm3Um4Gm3-s], containing the 2"-O-methyl groups on the nucleoside and sulphur groups on the internucleotidic bonds, and its anti-HIV-1 activity in cultured cells.	Nucleosides	268-278	CD4 molecule	Homo sapiens	110-113
12885121-0	2003	C-5 modified nucleosides: direct insertion of alkynyl-thio functionality in pyrimidines.	Nucleosides	13-24	complement C5	Homo sapiens	0-3
12643924-1	2003	We searched for non-nucleoside inhibitors of adenosine deaminase by rational structure-based de novo design and succeeded in the discovery of 1-(1-hydroxy-4-phenyl-2-butyl)imidazole-4-carboxamide (FR221647: K(i)=5.9 microM to human ADA) as a novel inhibitor with moderate activity and good pharmacokinetics compared with the known inhibitors pentostatin and EHNA.	Nucleosides	20-30	adenosine deaminase	Homo sapiens	232-235
12604712-9	2003	These studies indicated that replacement of the 4"-oxygen with sulfur significantly reduced the substrate activity of nucleoside analogs with dCK and that the superior activity of T-araC with respect to araC against solid tumors was not due to superior activity with dCK.	Nucleosides	118-128	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	142-145
12626708-5	2003	In addition, Ag-dNK could also phosphorylate some medically interesting nucleoside analogs, like stavudine (D4T), 2-chloro-deoxyadenosine (CdA) and 5-bromo-vinyl-deoxyuridine (BVDU).	Nucleosides	72-82	deoxyribonucleoside kinase	Drosophila melanogaster	16-19
12617905-0	2003	Oligonucleotides containing a new type of acyclic, achiral nucleoside analogue: 1-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]thymine.	Nucleosides	59-69	PROP paired-like homeobox 1	Homo sapiens	110-116
12590919-1	2003	Protein glycosylation is important for nucleoside transport, and this has been demonstrated for the human equilibrative nucleoside transporter-1 (hENT1).	Nucleosides	39-49	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	106-144
12590919-1	2003	Protein glycosylation is important for nucleoside transport, and this has been demonstrated for the human equilibrative nucleoside transporter-1 (hENT1).	Nucleosides	39-49	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	146-151
12612415-0	2003	Modification by fluoride, bromide, iodide, thiocyanate and nitrite anions of reaction of a myeloperoxidase-H2O2-Cl- system with nucleosides.	Nucleosides	128-139	myeloperoxidase	Homo sapiens	91-106
12612415-7	2003	These results suggest that Br(-) has a unique effect in relation to nucleoside damage caused by myeloperoxidase.	Nucleosides	68-78	myeloperoxidase	Homo sapiens	96-111
12608803-2	2003	The reaction scheme leads directly to the protected nucleosides without the need for the inversion of configuration of C-3 of 13C-glucose.	Nucleosides	52-63	complement C3	Homo sapiens	119-122
12566083-1	2003	Deoxycytidine kinase (dCK) catalyses the rate-limiting step of the salvage of three natural deoxyribonucleosides as well as several therapeutic nucleoside analogues, which in turn can enhance its enzymatic activity [Biochem Pharmacol 56 (1998) 1175], improving the efficacy of the cytostatic therapy.	Nucleosides	101-111	deoxycytidine kinase	Homo sapiens	0-20
12637246-0	2003	Metabolism of a novel nucleoside analogue, OGT 719, in the isolated perfused rat liver model, in rats, in tumour models and in patients.	Nucleosides	22-32	O-linked N-acetylglucosamine (GlcNAc) transferase	Rattus norvegicus	43-46
12637246-2	2003	The metabolic pathway(s) of OGT 719, a novel nucleoside analogue in which galactose is covalently attached to the N1 of 5-fluorouracil (FU), have been investigated with (19)F-NMR spectroscopy in (1) the isolated perfused rat liver (IPRL) model, (2) normal rats, (3) rats bearing the HSN LV10 sarcoma, (4) nude mice xenografted with the human hepatoma HepG2 and (5) urine from patients.	Nucleosides	45-55	O-linked N-acetylglucosamine (GlcNAc) transferase	Rattus norvegicus	28-31
12566083-1	2003	Deoxycytidine kinase (dCK) catalyses the rate-limiting step of the salvage of three natural deoxyribonucleosides as well as several therapeutic nucleoside analogues, which in turn can enhance its enzymatic activity [Biochem Pharmacol 56 (1998) 1175], improving the efficacy of the cytostatic therapy.	Nucleosides	101-111	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
12570853-1	2003	Four different approaches have been reviewed herein: i) nucleoside analogs as mock agents of the reverse transcriptase (hTERT) catalytic site; ii) miscellaneous molecules with unknown mechanism(s) of action; iii) inhibitors of upstream processes of regulation of the hTERT subunit; iiii) immunotherapy against immunogenic hTERT-derived peptides.	Nucleosides	56-66	telomerase reverse transcriptase	Homo sapiens	120-125
12527796-0	2003	Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase.	Nucleosides	4-14	thymidine kinase 2	Homo sapiens	61-65
12527796-8	2003	KIN-12, and particularly KIN-52, are the very first non-nucleoside specific inhibitors of TK-2 reported and may be useful for studying the physiological role of the mitochondrial TK-2 enzyme.	Nucleosides	56-66	thymidine kinase 2	Homo sapiens	90-94
12586359-6	2003	Ghrelin (10(-8) and 10(-6) M) raised basal, but not agonist-stimulated, proliferation rate of cultured ZG cells (percent of cells able to incorporate 5-bromo-2"-deoxyuridine), without affecting apoptotic deletion rate (percent of cells able to incorporate biotinylated nucleosides into apoptotic DNA fragments).	Nucleosides	269-280	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
12504799-3	2003	The CdA and CAFdA resistant cell lines exhibited increased resistance to the other nucleoside analogues activated by dCK.	Nucleosides	83-93	cytidine deaminase	Homo sapiens	4-7
12504799-3	2003	The CdA and CAFdA resistant cell lines exhibited increased resistance to the other nucleoside analogues activated by dCK.	Nucleosides	83-93	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	117-120
12429345-2	2002	Earlier studies showed that there are differences in kinetic properties between human and murine dCK, which may explain differences in toxic effects of nucleoside analogs.	Nucleosides	152-162	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	97-100
12517784-0	2003	A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues.	Nucleosides	245-255	high mobility group box 1	Homo sapiens	37-106
12517784-0	2003	A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues.	Nucleosides	245-255	protein disulfide isomerase family A member 3 pseudogene 1	Homo sapiens	108-113
12517784-0	2003	A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues.	Nucleosides	245-255	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	119-159
12517784-6	2003	These findings indicate that the HMGB1-HMGB2-HSC70-ERp60-glyceraldehyde 3-phosphate dehydrogenase complex detects changes in DNA structure caused by incorporation of nonnatural nucleosides and is a determinant of cell sensitivity to such DNA modifying chemotherapy.	Nucleosides	177-188	high mobility group box 1	Homo sapiens	33-38
12517784-6	2003	These findings indicate that the HMGB1-HMGB2-HSC70-ERp60-glyceraldehyde 3-phosphate dehydrogenase complex detects changes in DNA structure caused by incorporation of nonnatural nucleosides and is a determinant of cell sensitivity to such DNA modifying chemotherapy.	Nucleosides	177-188	high mobility group box 2	Homo sapiens	39-44
12517784-6	2003	These findings indicate that the HMGB1-HMGB2-HSC70-ERp60-glyceraldehyde 3-phosphate dehydrogenase complex detects changes in DNA structure caused by incorporation of nonnatural nucleosides and is a determinant of cell sensitivity to such DNA modifying chemotherapy.	Nucleosides	177-188	heat shock protein family A (Hsp70) member 8	Homo sapiens	45-50
12517784-6	2003	These findings indicate that the HMGB1-HMGB2-HSC70-ERp60-glyceraldehyde 3-phosphate dehydrogenase complex detects changes in DNA structure caused by incorporation of nonnatural nucleosides and is a determinant of cell sensitivity to such DNA modifying chemotherapy.	Nucleosides	177-188	protein disulfide isomerase family A member 3 pseudogene 1	Homo sapiens	51-56
12517784-6	2003	These findings indicate that the HMGB1-HMGB2-HSC70-ERp60-glyceraldehyde 3-phosphate dehydrogenase complex detects changes in DNA structure caused by incorporation of nonnatural nucleosides and is a determinant of cell sensitivity to such DNA modifying chemotherapy.	Nucleosides	177-188	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	57-97
12769724-2	2003	When conjugated to the nucleoside analog AZT, the resulting phospholipid-AZT conjugate can double target the virus replication cycle by inhibiting the viral reverse transcriptase (by AZT) and inducing the production of defective virus particles that lack functional gp120 expression on the virus surface resulting in reduced capacity to bind to CD4+ cells and inhibition of infected cell-cell fusion (by phospholipid).	Nucleosides	23-33	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	266-271
12769724-2	2003	When conjugated to the nucleoside analog AZT, the resulting phospholipid-AZT conjugate can double target the virus replication cycle by inhibiting the viral reverse transcriptase (by AZT) and inducing the production of defective virus particles that lack functional gp120 expression on the virus surface resulting in reduced capacity to bind to CD4+ cells and inhibition of infected cell-cell fusion (by phospholipid).	Nucleosides	23-33	CD4 molecule	Homo sapiens	345-348
12509998-1	2003	Purine nucleoside phosphorylase (PNP) catalyzes the phosphorolysis of the N-ribosidic bonds of purine nucleosides and deoxynucleosides.	Nucleosides	102-113	purine nucleoside phosphorylase	Homo sapiens	0-31
12509998-1	2003	Purine nucleoside phosphorylase (PNP) catalyzes the phosphorolysis of the N-ribosidic bonds of purine nucleosides and deoxynucleosides.	Nucleosides	102-113	purine nucleoside phosphorylase	Homo sapiens	33-36
12477353-12	2002	Thus, different substitution of the same nucleoside scaffold can target either of two P2Y receptors in platelets.	Nucleosides	41-51	purinergic receptor P2Y1	Rattus norvegicus	86-89
12897433-11	2003	However, it has been revealed that MRP4 can function as an efflux pump for cyclic nucleotides and nucleoside analogues, used as anti-HIV drugs.	Nucleosides	98-108	ATP binding cassette subfamily C member 4	Homo sapiens	35-39
12897433-12	2003	MRP5 also transports GSH conjugates, nucleoside analogues, and possibly heavy metal complexes.	Nucleosides	37-47	ATP binding cassette subfamily C member 5	Homo sapiens	0-4
12429345-7	2002	The kinetic patterns with several important nucleoside analogs, such as AraC, CdA, ddC and AraG have also been studied.	Nucleosides	44-54	cytidine deaminase	Homo sapiens	78-81
12419257-12	2002	As judged by hydroxyl radical footprinting and the missing nucleoside experiment, it appears that interaction of the Ubx recognition helix with the DNA major groove is reduced.	Nucleosides	59-69	Ultrabithorax	Drosophila melanogaster	117-120
12441131-3	2002	Plasma membrane preparations enriched in basolateral markers showed Na+-dependent nucleoside transport activity that is mostly, if not exclusively, accounted for by CNT2, a transporter protein which was not detected in CEF nor in the endosomal fractions.	Nucleosides	82-92	solute carrier family 28 member 2	Rattus norvegicus	165-169
12537023-0	2002	Kinetic and molecular modeling of nucleoside and nucleotide inhibition of malate dehydrogenase.	Nucleosides	34-44	malic enzyme 1	Homo sapiens	74-94
16120316-6	2002	High blood levels of this nucleoside are likely to lead to mtDNA defects even in cells that do not express TP, such as skeletal muscle.	Nucleosides	26-36	thymidine phosphorylase	Homo sapiens	107-109
12388627-9	2002	These data imply CNT3 may play a specialized role in nucleoside accumulation in milk and may identify an important role for PEPT2 and OATP-A transporters at the lactating mammary epithelium.	Nucleosides	53-63	solute carrier family 28 member 3	Homo sapiens	17-21
12537017-1	2002	Rotation of a heterocyclic base around a glycosidic bond allows the formation of syn and anti conformations in nucleosides.	Nucleosides	111-122	synemin	Homo sapiens	81-84
12150860-5	2002	Our results confirm that addition of a trifluoromethyl group at C-3" on such nucleoside derivatives appears to confer increased chemical stability toward acid-catalyzed cleavage of the glycosidic bond comparatively to their parent counterparts.	Nucleosides	77-87	complement C3	Homo sapiens	64-67
12370520-14	2002	CONCLUSION: NNRTI hypersusceptibility occurred in more than 20% of nucleoside-experienced patients and was associated with greater reduction of HIV RNA and increase in CD4 cells.	Nucleosides	67-77	CD4 molecule	Homo sapiens	168-171
12176019-1	2002	Most nucleoside-derived anticancer drugs are taken up by the high-affinity Na-dependent nucleoside transporter CNT1.	Nucleosides	5-15	solute carrier family 28 member 1	Rattus norvegicus	111-115
12207516-5	2002	A breakdown of the key Fermi contact part of (3)J(C6/8-H1") into MO contributions rationalizes this trend in terms of an unusual coupling mechanism in the syn orientation that is very effective for pyrimidine nucleosides and considerably weaker for purine nucleosides.	Nucleosides	209-220	synemin	Homo sapiens	155-158
12048183-2	2002	Human cytomegalovirus UL97 is an unusual protein kinase that can phosphorylate nucleoside analogs such as ganciclovir but whose specificity for exogenous protein substrates has remained unknown.	Nucleosides	79-89	tegument serine/threonine protein kinase	Human betaherpesvirus 5	22-26
12182625-4	2002	The most attractive features of this synthesis was that a relatively complex synthon was obtained from simple and inexpensive starting materials and that the resulting racemic mixtures of purine nucleosides could be successfully resolved by adenosine deaminase (ADA) hydrolysis.	Nucleosides	195-206	adenosine deaminase	Homo sapiens	241-260
12182625-4	2002	The most attractive features of this synthesis was that a relatively complex synthon was obtained from simple and inexpensive starting materials and that the resulting racemic mixtures of purine nucleosides could be successfully resolved by adenosine deaminase (ADA) hydrolysis.	Nucleosides	195-206	adenosine deaminase	Homo sapiens	262-265
12173924-6	2002	Steady-state kinetic analysis of T. vaginalis PNP-catalyzed reactions gave K(m)"s of 31.5, 59.7, and 6.1 microM for inosine, guanosine, and adenosine in the nucleosidase reaction and 45.6, 35.9, and 12.3 microM for hypoxanthine, guanine, and adenine in the direction of nucleoside synthesis.	Nucleosides	270-280	purine nucleoside phosphorylase	Homo sapiens	46-49
12057661-0	2002	Is the anomeric effect an important factor in the rate of adenosine deaminase catalyzed hydrolysis of purine nucleosides?	Nucleosides	109-120	adenosine deaminase	Homo sapiens	58-77
12077112-0	2002	Inhibition of nucleoside transport by p38 MAPK inhibitors.	Nucleosides	14-24	mitogen-activated protein kinase 14	Homo sapiens	38-41
12077112-1	2002	While investigating the ability of p38 MAPK to regulate cytarabine (Ara C)-dependent differentiation of erythroleukemia K562 cells, we observed effects that indicated that the imidazoline class of p38 MAPK inhibitors prevented nucleoside transport.	Nucleosides	227-237	mitogen-activated protein kinase 14	Homo sapiens	197-200
12110519-2	2002	In the present work, we studied the substrate specificities of the human and rat orthologs of the Na+-dependent purine-selective nucleoside transporter (SPNT; concentrative nucleoside transporter 2), for nucleosides, nucleobases, and base- and ribose-modified nucleoside analogs.	Nucleosides	204-215	solute carrier family 28 member 2	Rattus norvegicus	153-157
12110519-2	2002	In the present work, we studied the substrate specificities of the human and rat orthologs of the Na+-dependent purine-selective nucleoside transporter (SPNT; concentrative nucleoside transporter 2), for nucleosides, nucleobases, and base- and ribose-modified nucleoside analogs.	Nucleosides	129-139	solute carrier family 28 member 2	Rattus norvegicus	153-157
12110519-4	2002	Purine nucleosides and uridine induced currents in oocytes expressing rat SPNT (rSPNT) or human SPNT1 (hSPNT1).	Nucleosides	7-18	solute carrier family 28 member 2	Rattus norvegicus	74-78
12110519-4	2002	Purine nucleosides and uridine induced currents in oocytes expressing rat SPNT (rSPNT) or human SPNT1 (hSPNT1).	Nucleosides	7-18	solute carrier family 28 member 2	Rattus norvegicus	80-85
12110519-4	2002	Purine nucleosides and uridine induced currents in oocytes expressing rat SPNT (rSPNT) or human SPNT1 (hSPNT1).	Nucleosides	7-18	solute carrier family 28 member 2	Homo sapiens	96-101
12110519-4	2002	Purine nucleosides and uridine induced currents in oocytes expressing rat SPNT (rSPNT) or human SPNT1 (hSPNT1).	Nucleosides	7-18	solute carrier family 28 member 2	Homo sapiens	103-109
12110519-5	2002	The rank order of magnitude of nucleoside-induced currents was guanosine > uridine > adenosine > inosine and guanosine > uridine > inosine > adenosine for rSPNT- and hSPNT1-expressing oocytes, respectively.	Nucleosides	31-41	solute carrier family 28 member 2	Rattus norvegicus	173-178
12110519-5	2002	The rank order of magnitude of nucleoside-induced currents was guanosine > uridine > adenosine > inosine and guanosine > uridine > inosine > adenosine for rSPNT- and hSPNT1-expressing oocytes, respectively.	Nucleosides	31-41	solute carrier family 28 member 2	Homo sapiens	184-190
12110519-8	2002	The ribose-modified nucleoside analogs, adenine arabinoside, and 2",3"-dideoxyadenosine induced currents in rSPNT-expressing, but not in hSPNT1-expressing, oocytes.	Nucleosides	20-30	solute carrier family 28 member 2	Rattus norvegicus	108-113
12110519-9	2002	These data suggest that there are notable species differences in the specificity of SPNT for synthetic nucleoside analogs.	Nucleosides	103-113	solute carrier family 28 member 2	Homo sapiens	84-88
12119361-5	2002	The Km value of ATX for LPC was 25-fold lower than that for the synthetic nucleoside substrate, p-nitrophenyl-tri-monophosphate.	Nucleosides	74-84	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	16-19
12147295-0	2002	Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues.	Nucleosides	98-108	cytochrome c, somatic	Homo sapiens	67-79
12147295-1	2002	We have investigated whether nucleoside drugs that induce or protect neurones against apoptosis might directly activate or inhibit mitochondrial permeability transition (mPT) since opening of the mPT pore can promote release of cytochrome c and apoptosis, while its closure can prevent these changes.	Nucleosides	29-39	cytochrome c, somatic	Homo sapiens	228-240
12081495-18	2002	The deoxynucleosides 1 and 2 demonstrate that the chemical determinants for mechanism-based inhibition of CD38 can be satisfied by nucleosides that lack the 5"-phosphate, the adenylate group, and the 2"-hydroxyl moiety.	Nucleosides	9-20	CD38 molecule	Homo sapiens	106-110
12109910-3	2002	Binding studies demonstrated that the activities of 2-alkynylAdos were slightly increased for the adenosine A(1) receptor and slightly decreased for both A(3) and A(2B) subtypes compared to those of their corresponding NECA derivatives, whereas the A(2A) receptor affinities of the two series of nucleosides were similar.	Nucleosides	296-307	adenosine A1 receptor	Homo sapiens	98-121
12123738-1	2002	We previously reported that the rat organic cation transporter rOCT1 could transport the nucleoside analog deoxytubercidin (dTub) (Chen R, Nelson JA.	Nucleosides	89-99	solute carrier family 22 member 1	Rattus norvegicus	63-68
12123738-1	2002	We previously reported that the rat organic cation transporter rOCT1 could transport the nucleoside analog deoxytubercidin (dTub) (Chen R, Nelson JA.	Nucleosides	89-99	tube	Drosophila melanogaster	124-128
12006583-6	2002	These findings were independently confirmed by hypoxanthine transport experiments with recombinant hENT2 produced in purine-cytosine permease (FCY2)-deficient Saccharomyces cerevisiae and provide the first direct demonstration that the ENT2 isoform is a dual mechanism for the cellular uptake of nucleosides and nucleobases, both of which are physiologically important salvage metabolites.	Nucleosides	296-307	solute carrier family 29 member 2	Homo sapiens	99-104
12006583-6	2002	These findings were independently confirmed by hypoxanthine transport experiments with recombinant hENT2 produced in purine-cytosine permease (FCY2)-deficient Saccharomyces cerevisiae and provide the first direct demonstration that the ENT2 isoform is a dual mechanism for the cellular uptake of nucleosides and nucleobases, both of which are physiologically important salvage metabolites.	Nucleosides	296-307	purine-cytosine permease	Saccharomyces cerevisiae S288C	143-147
12006583-6	2002	These findings were independently confirmed by hypoxanthine transport experiments with recombinant hENT2 produced in purine-cytosine permease (FCY2)-deficient Saccharomyces cerevisiae and provide the first direct demonstration that the ENT2 isoform is a dual mechanism for the cellular uptake of nucleosides and nucleobases, both of which are physiologically important salvage metabolites.	Nucleosides	296-307	epsin	Saccharomyces cerevisiae S288C	100-104
12069239-1	2002	The human equilibrative nucleoside transporter 1 protein (hENT1) is a major mediator of cellular entry of nucleosides and anticancer nucleoside drugs; its assay is important in understanding and diagnosing chemotherapy resistance.	Nucleosides	106-117	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	10-48
12389626-11	2002	We conclude that, because hENT1 deficiency has been previously related to nucleoside-drug resistance, immunohistochemical staining for hENT1 warrants evaluation as a predictive tool for guiding the appropriate use of gemcitabine in the treatment of HD.	Nucleosides	74-84	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	26-31
12055084-1	2002	The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1, hCNT2, and hCNT3 are pyrimidine nucleoside-selective (system cit), purine nucleoside-selective (system cif), or broadly selective for both pyrimidine and purine nucleosides (system cib), respectively.	Nucleosides	240-251	solute carrier family 28 member 1	Homo sapiens	72-77
12055084-1	2002	The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1, hCNT2, and hCNT3 are pyrimidine nucleoside-selective (system cit), purine nucleoside-selective (system cif), or broadly selective for both pyrimidine and purine nucleosides (system cib), respectively.	Nucleosides	240-251	solute carrier family 28 member 2	Homo sapiens	79-84
12055084-1	2002	The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1, hCNT2, and hCNT3 are pyrimidine nucleoside-selective (system cit), purine nucleoside-selective (system cif), or broadly selective for both pyrimidine and purine nucleosides (system cib), respectively.	Nucleosides	240-251	solute carrier family 28 member 3	Homo sapiens	90-95
12111038-10	2002	CONCLUSION: I(K,ADO) contributes significantly to the negative dromotropic effect of adenosine, but predominantly at relatively high concentrations of the nucleoside.	Nucleosides	155-165	LOW QUALITY PROTEIN: 2-aminoethanethiol dioxygenase	Cavia porcellus	16-19
12069239-1	2002	The human equilibrative nucleoside transporter 1 protein (hENT1) is a major mediator of cellular entry of nucleosides and anticancer nucleoside drugs; its assay is important in understanding and diagnosing chemotherapy resistance.	Nucleosides	106-117	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	58-63
12069239-1	2002	The human equilibrative nucleoside transporter 1 protein (hENT1) is a major mediator of cellular entry of nucleosides and anticancer nucleoside drugs; its assay is important in understanding and diagnosing chemotherapy resistance.	Nucleosides	24-34	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	58-63
11967951-0	2002	Human prostate cancer cell death by novel anticancer compounds, apoptosis-inducing nucleosides from CD57+ HLA-DR(bright) natural suppressor cell line.	Nucleosides	83-94	beta-1,3-glucuronyltransferase 1	Homo sapiens	100-104
12054684-6	2002	The activity of dCK was decreased in the subline with higher resistance to Ara-G and these cells were highly cross-resistant to other nucleosides activated by dCK.	Nucleosides	134-145	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	16-19
12054684-6	2002	The activity of dCK was decreased in the subline with higher resistance to Ara-G and these cells were highly cross-resistant to other nucleosides activated by dCK.	Nucleosides	134-145	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	159-162
11967951-1	2002	BACKGROUND: We validated the induction of apoptosis in human prostate cancer PC3 cells by apoptosis-inducing nucleosides (AINs) released from the CD57(+)HLA-DR(bright)-natural suppressor (57.DR-NS) cell line.	Nucleosides	109-120	beta-1,3-glucuronyltransferase 1	Homo sapiens	146-150
11982471-4	2002	We assessed the effectiveness of long-term use of a nucleoside analog, lamivudine, in preventing HBV transmission by anti-HBc-positive allografts.	Nucleosides	52-62	keratin 88, pseudogene	Homo sapiens	122-125
11959550-2	2002	In the present study we describe the synthesis and properties of some nucleoside analogues that interact with double-stranded DNA but that, in contrast, facilitate the unwinding reaction mediated by West Nile (WN) virus nucleoside triphosphatase (NTPase)/helicase.	Nucleosides	70-80	inosine triphosphatase	Homo sapiens	220-245
11959550-2	2002	In the present study we describe the synthesis and properties of some nucleoside analogues that interact with double-stranded DNA but that, in contrast, facilitate the unwinding reaction mediated by West Nile (WN) virus nucleoside triphosphatase (NTPase)/helicase.	Nucleosides	70-80	inosine triphosphatase	Homo sapiens	247-253
11959550-2	2002	In the present study we describe the synthesis and properties of some nucleoside analogues that interact with double-stranded DNA but that, in contrast, facilitate the unwinding reaction mediated by West Nile (WN) virus nucleoside triphosphatase (NTPase)/helicase.	Nucleosides	70-80	helicase for meiosis 1	Homo sapiens	255-263
11959550-5	2002	The nucleoside analogues were nevertheless found to be capable of uncoupling the ATPase and helicase activities of the enzyme by a mechanism operating on the level of the enzyme.	Nucleosides	4-14	helicase for meiosis 1	Homo sapiens	92-100
12188390-8	2002	CONCLUSION: The preliminary data suggests that in antiretroviral-naive, advanced AIDS patients, 1,400 mg BID of saquinavir soft gel given with two nucleoside analogues might be as effective as the standard 1,200 mg TID.	Nucleosides	147-157	BH3 interacting domain death agonist	Homo sapiens	105-108
11980669-7	2002	Treatment with adenosine or nucleoside analogues may thus enhance the response to radiation or chemotherapy of tumors that express the PCPH oncogene.	Nucleosides	28-38	ectonucleoside triphosphate diphosphohydrolase 5 (inactive)	Homo sapiens	135-139
11961068-0	2002	Conjugates of nucleoside analogs with lactosaminated human albumin to selectively increase the drug levels in liver blood: requirements for a regional chemotherapy.	Nucleosides	14-24	albumin	Homo sapiens	59-66
11929265-5	2002	In contrast, the Os(II)-containing nucleoside is quite nonemissive in aqueous environment (tau = 0.027 micros, phi = 1 x 10(-4)).	Nucleosides	35-45	protein phosphatase 1 regulatory inhibitor subunit 14B	Homo sapiens	111-118
11996884-11	2002	These experiments indicate that many minor changes in amino acids forming all parts of the nucleoside binding pocket of AGT can alter its ability to react with BG and that the possibility that polymorphisms or variants may occur reducing the effectiveness of combination therapy with BG and alkylating agents must be considered.	Nucleosides	91-101	angiotensinogen	Homo sapiens	120-123
12062437-2	2002	We show that acute stimulation of protein kinase C (PKC) causes a rapid increase in S-(4-nitrobenzyl)-6-thioinosine-sensitive (human equilibrative nucleoside transporter 1, hENT1) nucleoside uptake, in human cultured cells, which is not due to increased metabolism and which can be blocked by PKC inhibitors.	Nucleosides	147-157	protein kinase C delta	Homo sapiens	52-55
11927571-5	2002	Three of these key residues in Drosophila dNK were then mutagenized and the mutant enzymes were characterized regarding their ability to phosphorylate native deoxyribonucleosides and nucleoside analogs.	Nucleosides	167-177	deoxyribonucleoside kinase	Drosophila melanogaster	42-45
11925245-10	2002	The latter process has been observed for other purine nucleosides, including the closely related 1d, and involves nucleophilic attack of OH(-) on C-8 to cleave the imidazole ring of the purine.	Nucleosides	54-65	homeobox C8	Homo sapiens	146-149
11912132-4	2002	The role of UMP/CMPK for the phosphorylation of nucleoside analogues has been indicated.	Nucleosides	48-58	cytidine/uridine monophosphate kinase 1	Homo sapiens	12-20
11867468-8	2002	The syn conformation is significantly more energetically accessible with guanine than with adenine in 5-nucleotides but not in nucleosides.	Nucleosides	127-138	synemin	Homo sapiens	4-7
11896685-0	2002	Characterization of nucleoside adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan.	Nucleosides	20-30	suppressor of cytokine signaling 2	Homo sapiens	42-47
11896543-1	2002	The relative levels of the deoxycytidine kinase (dCK), deoxyguanosine kinase (dGK), and the 5"-nucleotidase (5"-NT) are of importance for the effect of many nucleoside analogues used in the treatment of hematological malignancies.	Nucleosides	157-167	deoxycytidine kinase	Homo sapiens	27-47
11896543-1	2002	The relative levels of the deoxycytidine kinase (dCK), deoxyguanosine kinase (dGK), and the 5"-nucleotidase (5"-NT) are of importance for the effect of many nucleoside analogues used in the treatment of hematological malignancies.	Nucleosides	157-167	5'-nucleotidase ecto	Homo sapiens	92-107
11896543-1	2002	The relative levels of the deoxycytidine kinase (dCK), deoxyguanosine kinase (dGK), and the 5"-nucleotidase (5"-NT) are of importance for the effect of many nucleoside analogues used in the treatment of hematological malignancies.	Nucleosides	157-167	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	49-52
11896543-1	2002	The relative levels of the deoxycytidine kinase (dCK), deoxyguanosine kinase (dGK), and the 5"-nucleotidase (5"-NT) are of importance for the effect of many nucleoside analogues used in the treatment of hematological malignancies.	Nucleosides	157-167	deoxyguanosine kinase	Homo sapiens	55-76
11896543-1	2002	The relative levels of the deoxycytidine kinase (dCK), deoxyguanosine kinase (dGK), and the 5"-nucleotidase (5"-NT) are of importance for the effect of many nucleoside analogues used in the treatment of hematological malignancies.	Nucleosides	157-167	Diacyl glycerol kinase	Drosophila melanogaster	78-81
11814344-0	2002	A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1, alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine.	Nucleosides	47-57	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	76-81
11992640-1	2002	Deoxycytidine kinase (dCK) and deoxycytidine deaminase (dCDA) are two key enzymes in the activation and inactivation, respectively, of deoxycytidine (dCyd) and several chemotherapeutically important nucleoside analogues.	Nucleosides	199-209	deoxycytidine kinase	Rattus norvegicus	0-20
11992640-1	2002	Deoxycytidine kinase (dCK) and deoxycytidine deaminase (dCDA) are two key enzymes in the activation and inactivation, respectively, of deoxycytidine (dCyd) and several chemotherapeutically important nucleoside analogues.	Nucleosides	199-209	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
11814344-2	2002	hENT1 is involved in the uptake of natural nucleosides, including regulation of the physiological effects of extracellular adenosine, and transports nucleoside drugs used in the treatment of cancer and viral diseases.	Nucleosides	43-54	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	0-5
11814344-3	2002	Structure-function studies have revealed that transmembrane domains (TMD) 3 through 6 of hENT1 may be involved in binding of nucleosides.	Nucleosides	125-136	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	89-94
11730924-0	2002	Human malignant cell death by apoptosis-inducing nucleosides from the decidua derived CD57(+)HLA-DR(bright) natural suppressor cell line.	Nucleosides	49-60	beta-1,3-glucuronyltransferase 1	Homo sapiens	86-90
11752096-3	2002	Recent work has shown that nucleoside transport inhibition in combination with antifolates can be used to select in vivo for hematopoietic stem cells expressing drug-resistant dihydrofolate reductase (DHFR).	Nucleosides	27-37	dihydrofolate reductase	Mus musculus	176-199
11752096-3	2002	Recent work has shown that nucleoside transport inhibition in combination with antifolates can be used to select in vivo for hematopoietic stem cells expressing drug-resistant dihydrofolate reductase (DHFR).	Nucleosides	27-37	dihydrofolate reductase	Mus musculus	201-205
11730924-1	2002	The CD57(+)HLA-DR(bright) natural suppressor (57.DR-NS) cell line derived from human decidual tissue mediated apoptosis of human leukemia Molt4 and carcinoma BeWo/GCIY cells but not human fibroblast WI-38 cells, and apoptosis-inducing nucleosides (AINs) appeared to be involved.	Nucleosides	235-246	beta-1,3-glucuronyltransferase 1	Homo sapiens	4-8
11708915-0	2001	Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides.	Nucleosides	150-161	adenosine A3 receptor	Homo sapiens	72-95
11749958-3	2001	Yeast cells expressing ENT1,At are able to grow on adenosine-containing media, adenosine import exhibited an apparent affinity (K(M)) of 3.6 microM, and led to accumulation of this nucleoside within the yeast cell.	Nucleosides	181-191	epsin	Saccharomyces cerevisiae S288C	23-27
11708804-0	2001	Nucleoside analog cytotoxicity and bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in the nucleus or cytosol.	Nucleosides	0-10	deoxyribonucleoside kinase	Drosophila melanogaster	109-135
11751391-0	2001	Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage.	Nucleosides	45-55	tumor protein p53	Homo sapiens	15-18
11751391-0	2001	Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage.	Nucleosides	45-55	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	23-29
11751391-11	2001	These data suggest that DNA-PK and p53 may form a sensor complex that detects the disruption of DNA replication caused by nucleoside analogue incorporation and may subsequently signal for apoptosis.	Nucleosides	122-132	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	24-30
11751391-11	2001	These data suggest that DNA-PK and p53 may form a sensor complex that detects the disruption of DNA replication caused by nucleoside analogue incorporation and may subsequently signal for apoptosis.	Nucleosides	122-132	tumor protein p53	Homo sapiens	35-38
11584005-1	2001	The human equilibrative nucleoside transporter hENT1, the first identified member of the ENT family of integral membrane proteins, is the primary mechanism for the cellular uptake of physiologic nucleosides, including adenosine, and many anti-cancer nucleoside drugs.	Nucleosides	195-206	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	47-52
11584005-1	2001	The human equilibrative nucleoside transporter hENT1, the first identified member of the ENT family of integral membrane proteins, is the primary mechanism for the cellular uptake of physiologic nucleosides, including adenosine, and many anti-cancer nucleoside drugs.	Nucleosides	24-34	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	47-52
11708804-1	2001	We have recently shown that the overexpression of Drosophila melanogaster multisubstrate deoxyribonucleoside kinase (Dm-dNK) in cancer cell lines increases the cells" sensitivity to several cytotoxic nucleoside analogs and the enzyme may accordingly be used as a suicide gene in combined gene/chemotherapy treatment of cancer.	Nucleosides	98-108	deoxyribonucleoside kinase	Drosophila melanogaster	117-123
11602688-1	2001	The concentrative Na+ nucleoside transporter type 2 (CNT2), cloned from a rat blood-brain barrier cDNA library, yields very high flux ratios for purine nucleosides after expression in frog oocytes.	Nucleosides	152-163	solute carrier family 28 member 2	Rattus norvegicus	4-51
11533049-0	2001	Chlorination of guanosine and other nucleosides by hypochlorous acid and myeloperoxidase of activated human neutrophils.	Nucleosides	36-47	myeloperoxidase	Homo sapiens	73-88
11533049-8	2001	As the G-463A polymorphism of the MPO gene, which strongly reduces myeloperoxidase mRNA expression, is associated with a reduced risk of lung cancer, chlorination damage of DNA /RNA and nucleosides by myeloperoxidase and its enhancement by nicotine may be important in the pathophysiology of human diseases associated with tobacco habits.	Nucleosides	186-197	myeloperoxidase	Homo sapiens	34-37
11533049-8	2001	As the G-463A polymorphism of the MPO gene, which strongly reduces myeloperoxidase mRNA expression, is associated with a reduced risk of lung cancer, chlorination damage of DNA /RNA and nucleosides by myeloperoxidase and its enhancement by nicotine may be important in the pathophysiology of human diseases associated with tobacco habits.	Nucleosides	186-197	myeloperoxidase	Homo sapiens	201-216
11677121-0	2001	A unique ring-expanded acyclic nucleoside analogue that inhibits both adenosine deaminase (ADA) and guanine deaminase (GDA; guanase): synthesis and enzyme inhibition studies of 4,6-diamino-8H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine.	Nucleosides	31-41	adenosine deaminase	Homo sapiens	70-89
11677121-0	2001	A unique ring-expanded acyclic nucleoside analogue that inhibits both adenosine deaminase (ADA) and guanine deaminase (GDA; guanase): synthesis and enzyme inhibition studies of 4,6-diamino-8H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine.	Nucleosides	31-41	adenosine deaminase	Homo sapiens	91-94
11677121-0	2001	A unique ring-expanded acyclic nucleoside analogue that inhibits both adenosine deaminase (ADA) and guanine deaminase (GDA; guanase): synthesis and enzyme inhibition studies of 4,6-diamino-8H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine.	Nucleosides	31-41	guanine deaminase	Homo sapiens	100-117
11677121-0	2001	A unique ring-expanded acyclic nucleoside analogue that inhibits both adenosine deaminase (ADA) and guanine deaminase (GDA; guanase): synthesis and enzyme inhibition studies of 4,6-diamino-8H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine.	Nucleosides	31-41	guanine deaminase	Homo sapiens	119-122
11677121-0	2001	A unique ring-expanded acyclic nucleoside analogue that inhibits both adenosine deaminase (ADA) and guanine deaminase (GDA; guanase): synthesis and enzyme inhibition studies of 4,6-diamino-8H-1-hydroxyethoxymethyl-8-iminoimidazo[4,5-e][1,3]diazepine.	Nucleosides	31-41	guanine deaminase	Homo sapiens	124-131
11689002-0	2001	Human serum albumin binding of novel antiretroviral nucleoside derivatives of AZT.	Nucleosides	52-62	albumin	Homo sapiens	6-19
11689002-1	2001	The binding of novel nucleoside derivatives (2-7) to the Human Serum Albumin (HSA) was studied using zidovudine (AZT), as standard compound.	Nucleosides	21-31	albumin	Homo sapiens	63-76
11602688-1	2001	The concentrative Na+ nucleoside transporter type 2 (CNT2), cloned from a rat blood-brain barrier cDNA library, yields very high flux ratios for purine nucleosides after expression in frog oocytes.	Nucleosides	152-163	solute carrier family 28 member 2	Rattus norvegicus	53-57
11593298-11	2001	The ecto-5"-nucleotidase (EC 3.1.3.5) and ectoadenosine deaminase activities (specific activities of 32 +/- 2 nmol Pi mg(-1) min(-1) for AMP and 1.52 +/- 0.13 nmol adenosine mg(-1) min(-1), respectively) were shown to be able to terminate the effects of purines and may be relevant for the physiological control of extracellular levels of nucleotides and nucleosides inside the seminiferous tubules.	Nucleosides	355-366	5' nucleotidase, ecto	Rattus norvegicus	4-24
11641443-7	2001	The impact of hCNT2-mediated transport on chemosensitivity was assessed by comparing antiproliferative activity of nucleoside analogs against hCNT2-containing cells with transport-defective, drug-resistant cells.	Nucleosides	115-125	solute carrier family 28 member 2	Homo sapiens	14-19
11592340-0	2001	Bioavailability study of oral and intravenous OGT 719, a novel nucleoside analogue with preferential activity in the liver.	Nucleosides	63-73	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	46-49
11559796-5	2001	Duplication of the proline-rich p6(Gag) PTAP motif, necessary for late viral cycle activities, was identified in plasma virus from 47 of 222 (21.2%) patients treated with nucleoside analog RT inhibitor (NRTI) antiretroviral therapy but was identified very rarely from drug-naive individuals.	Nucleosides	171-181	S100 calcium binding protein A12	Homo sapiens	32-39
11592340-2	2001	OGT 719 (1-galactopyranosyl-5-fluorouracil) is a novel nucleoside analogue, preferentially localized in hepatocytes and hepatoma cells via the asialoglycoprotein receptor.	Nucleosides	55-65	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	0-3
11593336-2	2001	We have shown previously that the human cytidine deaminase (CD) gene can confer drug resistance in murine bone marrow cells (BMCs) to the nucleoside analog, cytosine arabinoside (ARA-C).	Nucleosides	138-148	cytidine deaminase	Homo sapiens	40-58
11593336-2	2001	We have shown previously that the human cytidine deaminase (CD) gene can confer drug resistance in murine bone marrow cells (BMCs) to the nucleoside analog, cytosine arabinoside (ARA-C).	Nucleosides	138-148	cytidine deaminase	Homo sapiens	60-62
11502887-2	2001	In this study, we show that treatment with the 2",3"-dideoxycytidine (ddC) nucleoside analog inhibited in vitro and in vivo the proliferation of Pol beta-transfected B16 melanoma cells, which up-regulate Pol beta compared with control isogenic cells.	Nucleosides	75-85	polymerase (DNA directed), beta	Mus musculus	145-153
12825459-1	2001	Ribavirin, a nucleoside analog, used in combination with interferon-alpha (IFN alpha) results in a substantial improvement in the sustained virologic response in chronic hepatitis C. Identified antiviral mechanisms of action for ribavirin include: (i) inhibition of viral encoded polymerases; (ii) inhibition of genomic RNA capping; and (iii) inhibition of cellular encoded enzymes that control de novo synthesis of purine nucleosides.	Nucleosides	423-434	interferon alpha 1	Homo sapiens	75-84
11570579-7	2001	Moreover, we found that most of the apoptotic parameters in adenosine-induced cellular changes, such as translocation of Bax, the release of cytochrome c, and the consequent activation of caspase-9 and caspase-3, were attenuated by thymidine supplement, thus indicating that the sensing of a nucleoside or nucleotide balance might be an upstream event of cytochrome c release.	Nucleosides	292-302	caspase 9	Homo sapiens	188-197
11504818-7	2001	The present study shows that rOat2 is a multispecific transporter and suggests that it may be involved at least partly, in the hepatic uptake of IDM, salicylate and nucleoside derivatives.	Nucleosides	165-175	solute carrier family 22 (organic anion transporter), member 7, pseudogene 1	Rattus norvegicus	29-34
11502887-2	2001	In this study, we show that treatment with the 2",3"-dideoxycytidine (ddC) nucleoside analog inhibited in vitro and in vivo the proliferation of Pol beta-transfected B16 melanoma cells, which up-regulate Pol beta compared with control isogenic cells.	Nucleosides	75-85	polymerase (DNA directed), beta	Mus musculus	204-212
11511175-5	2001	The molecular ions and fragmentation of the dGuo, dAdo, and dCyd adducts were consistent with nucleophilic addition of the exocyclic primary amine of the nucleosides to the methylene carbon of 3-methyleneindolenine.	Nucleosides	154-165	ado	Drosophila melanogaster	50-54
11466296-3	2001	Disruption of PNP1 led to inosine and guanosine excretion in the medium, thus showing that PNP1 plays an important role in the metabolism of these purine nucleosides in vivo.	Nucleosides	154-165	purine-nucleoside phosphorylase	Saccharomyces cerevisiae S288C	14-18
11466296-3	2001	Disruption of PNP1 led to inosine and guanosine excretion in the medium, thus showing that PNP1 plays an important role in the metabolism of these purine nucleosides in vivo.	Nucleosides	154-165	purine-nucleoside phosphorylase	Saccharomyces cerevisiae S288C	91-95
11547345-2	2001	CFTR proteins are members of the ABC transporter family and are complexly regulated by phosphorylation and nucleosides; they also influence other channel activity.	Nucleosides	107-118	CF transmembrane conductance regulator	Homo sapiens	0-4
11375981-3	2001	rCNT1 was found to be expressed predominantly in the brush-border membranes of the polarized epithelial cells of rat jejunum and renal cortical tubules and in the bile canalicular membranes of liver parenchymal cells, consistent with roles in the absorption of dietary nucleosides, of nucleosides in the glomerular filtrate, or of nucleosides arising from the action of extracellular nucleotidases, respectively.	Nucleosides	269-280	solute carrier family 28 member 1	Rattus norvegicus	0-5
11455012-2	2001	The cells expressing Dm-dNK exhibit increased sensitivity to several cytotoxic nucleoside analogs.	Nucleosides	79-89	deoxyribonucleoside kinase	Drosophila melanogaster	21-27
11375981-3	2001	rCNT1 was found to be expressed predominantly in the brush-border membranes of the polarized epithelial cells of rat jejunum and renal cortical tubules and in the bile canalicular membranes of liver parenchymal cells, consistent with roles in the absorption of dietary nucleosides, of nucleosides in the glomerular filtrate, or of nucleosides arising from the action of extracellular nucleotidases, respectively.	Nucleosides	285-296	solute carrier family 28 member 1	Rattus norvegicus	0-5
11375981-3	2001	rCNT1 was found to be expressed predominantly in the brush-border membranes of the polarized epithelial cells of rat jejunum and renal cortical tubules and in the bile canalicular membranes of liver parenchymal cells, consistent with roles in the absorption of dietary nucleosides, of nucleosides in the glomerular filtrate, or of nucleosides arising from the action of extracellular nucleotidases, respectively.	Nucleosides	285-296	solute carrier family 28 member 1	Rattus norvegicus	0-5
11304122-4	2001	When DNA or nucleosides were incubated with COX-2 and arachidonic acid, a significant increase in the amount of 8-oxo-2"-deoxyguanosine was observed.	Nucleosides	12-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49
11444371-3	2001	Of the nearly 300 nucleosides known, about 250 are in the anti conformation and 50 are in the syn-conformation, i.e., anti to syn conformation is 5:1.	Nucleosides	18-29	synemin	Homo sapiens	94-97
11444371-3	2001	Of the nearly 300 nucleosides known, about 250 are in the anti conformation and 50 are in the syn-conformation, i.e., anti to syn conformation is 5:1.	Nucleosides	18-29	synemin	Homo sapiens	126-129
11369435-1	2001	Nucleoside diphosphate (NDP) kinase is usually considered as the enzyme responsible for the last step of the cellular phosphorylation pathway leading to the synthesis of biologically active triphospho-derivatives of nucleoside analogs used in antiviral therapies and in particular in the treatment of AIDS.	Nucleosides	216-226	cytidine/uridine monophosphate kinase 2	Homo sapiens	0-35
11369435-3	2001	However, only nucleoside analogs with a sugar moiety in the D-configuration (e.g. 3"-deoxy-3"-azidothymidine (AZT), 2",3"-didehydro-2",3"-dideoxythymidine (d4T)) have so far been analyzed as substrates of NDP kinase.	Nucleosides	14-24	cytidine/uridine monophosphate kinase 2	Homo sapiens	205-215
11387351-2	2001	PATIENTS AND METHODS: Between June 1991 and December 1996, we administered the nucleoside analog 2-chlorodeoxyadenosine (2-CDA) to 73 children with primary AML and 20 children with secondary AML or myelodysplastic syndrome (MDS).	Nucleosides	79-89	cytidine deaminase	Homo sapiens	123-126
11340175-7	2001	Analysis of the tRNA([Ser]Sec) population showed that expression of i(6)A(-) tRNA([Ser]Sec) altered the distribution of the two major isoforms, whereby the maturation of tRNA([Ser]Sec) by methylation of the nucleoside in the wobble position was repressed.	Nucleosides	207-217	eukaryotic elongation factor, selenocysteine-tRNA-specific	Mus musculus	87-90
11340175-7	2001	Analysis of the tRNA([Ser]Sec) population showed that expression of i(6)A(-) tRNA([Ser]Sec) altered the distribution of the two major isoforms, whereby the maturation of tRNA([Ser]Sec) by methylation of the nucleoside in the wobble position was repressed.	Nucleosides	207-217	eukaryotic elongation factor, selenocysteine-tRNA-specific	Mus musculus	87-90
11376566-1	2001	The mechanism of action of the antitumor nucleoside analog 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine (4"-thio-FAC) was investigated.	Nucleosides	41-51	FA complementation group C	Homo sapiens	128-131
11309295-16	2001	When BrdUrd was added 24 h after rapamycin, almost 90% and 70% of cells lacking p53 or p21(CIP1), respectively, incorporated nucleoside.	Nucleosides	125-135	cyclin dependent kinase inhibitor 1A	Homo sapiens	91-95
11563046-4	2001	Conformational constraints were built into the ribose rings of nucleoside and nucleotide ligands using the methanocarba approach, i.e. fused cyclopropane and cyclopentane rings in place of ribose, suggesting a preference for the Northern (N) conformation among ligands for P2Y1 and A1 and A3ARs.	Nucleosides	63-73	purinergic receptor P2Y1	Homo sapiens	273-294
11251182-0	2001	Active roles of caspase-3 in human gastric carcinoma cell death by apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line.	Nucleosides	86-97	caspase 3	Homo sapiens	16-25
11463208-1	2001	In the present study, one has determined the relative role of plasma membrane equilibrative (Na+-independent) ENT nucleoside transport proteins (particularly ENT2) in the uptake of antiviral nucleoside analogues for comparison with the previously reported drug transport properties of concentrative (Na+-dependent) CNT nucleoside transport proteins.	Nucleosides	114-124	solute carrier family 29 member 2	Homo sapiens	158-162
11311901-6	2001	The apparent reciprocal distribution of hENT1 and hENT2 in human brain suggests that these nucleoside transporter proteins are produced in distinct regions of the CNS where they function in nucleoside salvage and/or regulation of exogenous adenosine.	Nucleosides	91-101	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	40-45
11311901-6	2001	The apparent reciprocal distribution of hENT1 and hENT2 in human brain suggests that these nucleoside transporter proteins are produced in distinct regions of the CNS where they function in nucleoside salvage and/or regulation of exogenous adenosine.	Nucleosides	91-101	solute carrier family 29 member 2	Homo sapiens	50-55
11263895-1	2001	Nucleosides and nucleotides which are able to undergo covalent hydration in the aglycone ring system are potential inhibitors of the enzymes adenosine deaminase (ADA) and AMP deaminase, respectively.	Nucleosides	0-11	adenosine deaminase	Homo sapiens	141-160
11133996-0	2001	Human cytosolic 5"-nucleotidase I: characterization and role in nucleoside analog resistance.	Nucleosides	64-74	5'-nucleotidase, cytosolic IA	Homo sapiens	6-31
11133996-4	2001	We have cloned and characterized a novel human cytosolic 5"-nucleotidase (cN-I) that potentially may have an important role in nucleoside analog metabolism.	Nucleosides	127-137	5'-nucleotidase, cytosolic IA	Homo sapiens	47-72
11133996-4	2001	We have cloned and characterized a novel human cytosolic 5"-nucleotidase (cN-I) that potentially may have an important role in nucleoside analog metabolism.	Nucleosides	127-137	5'-nucleotidase, cytosolic IA	Homo sapiens	74-78
11133996-10	2001	These data indicate that cN-I may play an important role in the regulation of physiological pyrimidine nucleotide pools and may also alter the therapeutic efficacy of certain nucleoside analogs.	Nucleosides	175-185	5'-nucleotidase, cytosolic IA	Homo sapiens	25-29
11263895-1	2001	Nucleosides and nucleotides which are able to undergo covalent hydration in the aglycone ring system are potential inhibitors of the enzymes adenosine deaminase (ADA) and AMP deaminase, respectively.	Nucleosides	0-11	adenosine deaminase	Homo sapiens	162-165
11320667-1	2001	PURPOSE: Troxacitabine (beta-L-dioxolane cytidine, BCH-4556; Troxatyl, BioChem Pharma Inc.) is a novel nucleoside analogue, which in experiments demonstrated potent antitumor activity against both leukemias and solid tumors.	Nucleosides	103-113	chimerin 2	Homo sapiens	51-54
11096071-6	2001	Remarkably, both myeloperoxidase and eosinophil peroxidase were able to brominate deoxycytidine, a nucleoside, and uracil, a nucleobase, at plasma concentrations of Br(-) (100 microM) and Cl(-) (100 mM).	Nucleosides	99-109	myeloperoxidase	Homo sapiens	17-32
11096071-6	2001	Remarkably, both myeloperoxidase and eosinophil peroxidase were able to brominate deoxycytidine, a nucleoside, and uracil, a nucleobase, at plasma concentrations of Br(-) (100 microM) and Cl(-) (100 mM).	Nucleosides	99-109	eosinophil peroxidase	Homo sapiens	37-58
11396612-4	2001	Whilst the name of the family reflects the properties of its prototypical member hENT1, an equilibrative transporter of nucleosides, some family members can also transport nucleobases and some are proton-dependent, concentrative transporters.	Nucleosides	120-131	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	81-86
11426528-1	2001	Cladribine (2-chlorodeoxyadenosine, 2-CdA) is a nucleoside analog with substituted halogen atom at position 2 in its purine ring that makes it resistant to deamination by adenosine deaminase (ADA).	Nucleosides	48-58	cytidine deaminase	Homo sapiens	38-41
11426528-1	2001	Cladribine (2-chlorodeoxyadenosine, 2-CdA) is a nucleoside analog with substituted halogen atom at position 2 in its purine ring that makes it resistant to deamination by adenosine deaminase (ADA).	Nucleosides	48-58	adenosine deaminase	Homo sapiens	171-190
11032837-1	2001	The human concentrative (Na(+)-linked) plasma membrane transport proteins hCNT1 and hCNT2 are selective for pyrimidine nucleosides (system cit) and purine nucleosides (system cif), respectively.	Nucleosides	119-130	solute carrier family 28 member 1	Homo sapiens	74-79
11032837-1	2001	The human concentrative (Na(+)-linked) plasma membrane transport proteins hCNT1 and hCNT2 are selective for pyrimidine nucleosides (system cit) and purine nucleosides (system cif), respectively.	Nucleosides	119-130	solute carrier family 28 member 2	Homo sapiens	84-89
11206479-1	2001	N6-Naphthalenemethyl-2"-methoxybenzamido-beta-NAD+, a derivative of a low micromolar first-generation inhibitor of trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH), was synthesized, taking advantage of methodology for the selective phosphitylation of nucleosides.	Nucleosides	262-273	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	168-173
11811845-8	2001	Endothelin-1 on GLIB-treated coronaries further diminished RH and increased nucleoside release (EF: 21.5+/-8.0 ml, P<0.05 vs. GLIB; adenosine: 75.3+/-28.1 nmol, NS; inosine: 801.9+/-196.6 nmol, P<0.05 vs. GLIB).	Nucleosides	76-86	endothelin 1	Canis lupus familiaris	0-12
11830758-4	2001	Structurally novel nucleoside and non-nucleoside AK inhibitors that demonstrate high specificity for the AK enzyme compared with other ADO metabolic enzymes, transporters, and receptors have recently been synthesized.	Nucleosides	19-29	adenosine kinase	Homo sapiens	105-107
11134952-1	2001	Queuosine is a modified nucleoside located at the first position of the tRNA anticodon, which is synthesized by tRNA-guanine transglycosylase (TGT).	Nucleosides	24-34	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	112-141
11134952-1	2001	Queuosine is a modified nucleoside located at the first position of the tRNA anticodon, which is synthesized by tRNA-guanine transglycosylase (TGT).	Nucleosides	24-34	queuine tRNA-ribosyltransferase catalytic subunit 1	Homo sapiens	143-146
11396613-1	2001	The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1 and hCNT2, found primarily in specialized epithelia, are selective for pyrimidine nucleosides (system cit) and purine nucleosides (system cif), respectively.	Nucleosides	160-171	solute carrier family 28 member 1	Homo sapiens	72-77
11396613-1	2001	The human concentrative (Na+-linked) plasma membrane transport proteins hCNT1 and hCNT2, found primarily in specialized epithelia, are selective for pyrimidine nucleosides (system cit) and purine nucleosides (system cif), respectively.	Nucleosides	160-171	solute carrier family 28 member 2	Homo sapiens	82-87
11396613-5	2001	hCNT3 and mCNT3 have primary structures that place them in a CNT subfamily separate from CNT1/2, transport a wide range of physiological pyrimidine and purine nucleosides and antineoplastic and antiviral nucleoside drugs (system cib), and exhibit a Na+:uridine coupling ratio of at least 2:1 (cf 1:1 for hCNT1/2).	Nucleosides	159-170	solute carrier family 28 member 3	Homo sapiens	0-5
11396613-5	2001	hCNT3 and mCNT3 have primary structures that place them in a CNT subfamily separate from CNT1/2, transport a wide range of physiological pyrimidine and purine nucleosides and antineoplastic and antiviral nucleoside drugs (system cib), and exhibit a Na+:uridine coupling ratio of at least 2:1 (cf 1:1 for hCNT1/2).	Nucleosides	159-170	solute carrier family 28 (sodium-coupled nucleoside transporter), member 3	Mus musculus	10-15
11329271-0	2001	Eosinophil peroxidase catalyzes bromination of free nucleosides and double-stranded DNA.	Nucleosides	52-63	eosinophil peroxidase	Homo sapiens	0-21
11154902-1	2001	The interaction of twelve 8-substituted-2"-deoxyadenosine and seventeen 5-substituted-2"-deoxyuridine derivatives (antisense nucleosides) with cyclomalto-octaose (GCD) was determined by charge-transfer chromatography and the relative strength of the interaction was calculated.	Nucleosides	125-136	guanylate cyclase 2E, pseudogene	Homo sapiens	163-166
11154902-2	2001	The majority of antisense nucleosides (14 deoxyuridine and 11 deoxyadenosine derivatives) interacted with GCD, which probably led to inclusion complex formation.	Nucleosides	26-37	guanylate cyclase 2E, pseudogene	Homo sapiens	106-109
12836319-2	2001	To develop a nucleoside analogue to interact with T.A interruption, we designed and synthesized a novel 2",4"-BNA monomer (HBB), 2-(2"-O,4"-C-methyleneribofuranosyl)phenol, and it was introduced into a triplex-forming oligonucleotide (TFO).	Nucleosides	13-23	hemoglobin subunit beta	Homo sapiens	123-126
11150511-1	2000	Deoxycytidine kinase (dCK) phosphorylates several anti-cancer and anti-viral nucleoside analogs.	Nucleosides	77-87	deoxycytidine kinase	Homo sapiens	0-20
11150511-1	2000	Deoxycytidine kinase (dCK) phosphorylates several anti-cancer and anti-viral nucleoside analogs.	Nucleosides	77-87	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
11090748-1	2000	BACKGROUND: The Murex-Innogenetics LiPA HIV-1 RT assay can be used to identify the presence of mutations of the reverse transcriptase gene at codons 41, 69, 70, 74, 184 and 215 of HIV-1, which have been shown to confer resistance to the nucleoside analogs Zidovudine (ZDV), Lamivudine (3TC), Didanosine (ddI) and Zalcitabine (ddC).	Nucleosides	237-247	lipase A, lysosomal acid type	Homo sapiens	35-39
10993893-7	2000	The cells expressing Dm-dNK exhibited increased sensitivity to several cytotoxic nucleoside analogs, such as 1-beta-d-arabinofuranosylcytosine, 1-beta-d-arabinofuranosylthymine, (E)-5-(2-bromovinyl)-2"-deoxyuridine, 2-chloro-2"-deoxyadenosine, and 2",2"-difluorodeoxycytidine.	Nucleosides	81-91	deoxyribonucleoside kinase	Drosophila melanogaster	21-27
11113083-1	2000	BACKGROUND & AIMS: Concentrative nucleoside transporters CNT1 (pyrimidine preferring) and CNT2 (purine preferring) may be involved in the uptake of nucleoside-derived drugs used in antiviral and chemical therapies.	Nucleosides	37-47	solute carrier family 28 member 1	Rattus norvegicus	61-65
11113083-1	2000	BACKGROUND & AIMS: Concentrative nucleoside transporters CNT1 (pyrimidine preferring) and CNT2 (purine preferring) may be involved in the uptake of nucleoside-derived drugs used in antiviral and chemical therapies.	Nucleosides	37-47	solute carrier family 28 member 2	Rattus norvegicus	94-98
11071652-4	2000	The nucleoside-induced damage leads to the release of the pro-apoptotic mitochondrial proteins cytochrome c and apoptosis-inducing factor.	Nucleosides	4-14	cytochrome c, somatic	Homo sapiens	95-107
11337031-8	2000	Also described are applications of PNP from various sources as tools for the enzymatic synthesis of otherwise inaccessible therapeutic nucleoside analogues, as coupling enzymes for assays of orthophosphate in biological systems in the micromolar and submicromolar ranges, and for coupled assays of other enzyme systems.	Nucleosides	135-145	purine nucleoside phosphorylase	Homo sapiens	35-38
11101439-0	2000	Synthesis and biophysical characterization of tRNA(Lys,3) anticodon stem-loop RNAs containing the mcm(5)s(2)U nucleoside.	Nucleosides	110-120	mitochondrially encoded tRNA glycine	Homo sapiens	46-56
11006103-3	2000	Hydroxyurea showed synergistic cytotoxicity with the nucleoside analogs 1-beta-d-arabinofuranosylcytosine and 2-chloro-2"-deoxyadenosine when dCK was expressed in the cytosol or in the nucleus, but not when dCK was expressed in the mitochondria.	Nucleosides	53-63	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	142-145
11103806-8	2000	Finally, the JNK1 signaling pathway appeared to be upstream to that of the effector caspases in nucleoside analogue-induced apoptosis.	Nucleosides	96-106	mitogen-activated protein kinase 8	Homo sapiens	13-17
11027231-5	2000	The expression of the MBP-TK transgene in oligodendrocytes is not toxic on its own; however, toxicity can be selectively induced by the systemic injection of animals with nucleoside analogs, such as FIAU [1-(2-deoxy-2-fluoro-beta-delta-arabinofuranosyl)-5-iodouracil].	Nucleosides	171-181	myelin basic protein	Mus musculus	22-25
11020446-1	2000	Antileukemic interactions between the nucleoside analog 1-beta-D-arabinofuranosylcytosine (ara-C) and the kinase inhibitor 7-hydroxystaurosporine (UCN-01) have been examined in relation to Bcl-2 expression/phosphorylation, mitochondrial damage, caspase activation, and loss of clonogenic potential.	Nucleosides	38-48	urocortin	Homo sapiens	147-150
10906132-6	2000	APE1 preferred to remove l- over d-configuration nucleosides from 3" termini of DNA.	Nucleosides	49-60	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	0-4
10869342-5	2000	Here we show that CobU requires a nucleoside upper ligand on cobinamide for substrate recognition, with the nucleoside base, but not the 2"-OH group of the ribose, being important for this recognition.	Nucleosides	34-44	bifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	18-22
10996312-0	2000	Electrogenic uptake of nucleosides and nucleoside-derived drugs by the human nucleoside transporter 1 (hCNT1) expressed in Xenopus laevis oocytes.	Nucleosides	23-34	solute carrier family 28 member 1	Homo sapiens	103-108
10996312-0	2000	Electrogenic uptake of nucleosides and nucleoside-derived drugs by the human nucleoside transporter 1 (hCNT1) expressed in Xenopus laevis oocytes.	Nucleosides	23-33	solute carrier family 28 member 1	Homo sapiens	103-108
10996312-6	2000	The analysis of the currents generated by the hCNT1-mediated transport of nucleoside-derived drugs used in anticancer and antiviral therapies will be useful in the characterization of the pharmacological profile of this family of drug transporters and will allow rapid screening for uptake of newly developed nucleoside-derived drugs.	Nucleosides	74-84	solute carrier family 28 member 1	Homo sapiens	46-51
10996312-6	2000	The analysis of the currents generated by the hCNT1-mediated transport of nucleoside-derived drugs used in anticancer and antiviral therapies will be useful in the characterization of the pharmacological profile of this family of drug transporters and will allow rapid screening for uptake of newly developed nucleoside-derived drugs.	Nucleosides	309-319	solute carrier family 28 member 1	Homo sapiens	46-51
10827186-6	2000	The nucleoside analogs phosphorylated by dCK in the mitochondria were predominantly incorporated into mitochondrial DNA, whereas the nucleoside analogs phosphorylated in the nucleus or cytosol were incorporated into nuclear DNA.	Nucleosides	4-14	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	41-44
10950861-4	2000	The purpose of this study was to directly measure the transport of nucleoside analogs by the sodium-coupled pyrimidine-selective transporter rCNT1 using electrophysiology methods.	Nucleosides	67-77	solute carrier family 28 member 1	Rattus norvegicus	141-146
10950861-5	2000	We used a two-electrode voltage clamp assay to investigate the substrate selectivity of rCNT1; 19 structurally diverse nucleosides and nucleoside analogs were studied.	Nucleosides	119-130	solute carrier family 28 member 1	Rattus norvegicus	88-93
10950861-5	2000	We used a two-electrode voltage clamp assay to investigate the substrate selectivity of rCNT1; 19 structurally diverse nucleosides and nucleoside analogs were studied.	Nucleosides	119-129	solute carrier family 28 member 1	Rattus norvegicus	88-93
10827169-7	2000	These results indicated that FUI1 has high selectivity for uracil-containing ribonucleosides and imports uridine across cell-surface membranes, whereas FUN26 has broad nucleoside selectivity and most likely functions to transport nucleosides across intracellular membranes.	Nucleosides	81-92	uridine permease	Saccharomyces cerevisiae S288C	29-33
10945832-0	2000	Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs.	Nucleosides	108-118	solute carrier family 22 member 6	Rattus norvegicus	18-45
10945832-0	2000	Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs.	Nucleosides	108-118	solute carrier family 22 member 6	Rattus norvegicus	47-52
10945832-3	2000	In this study, we investigated the transport of antiviral nucleoside analogs via rat OAT1 (rOAT1) using a heterologous expression system in Xenopus laevis oocytes.	Nucleosides	58-68	solute carrier family 22 member 6	Rattus norvegicus	85-89
10945832-3	2000	In this study, we investigated the transport of antiviral nucleoside analogs via rat OAT1 (rOAT1) using a heterologous expression system in Xenopus laevis oocytes.	Nucleosides	58-68	solute carrier family 22 member 6	Rattus norvegicus	91-96
10945832-9	2000	This study demonstrates extension of the substrate spectrum of rOAT1 and provides a molecular basis for the pharmacokinetics of antiviral nucleoside analogs.	Nucleosides	138-148	solute carrier family 22 member 6	Rattus norvegicus	63-68
10944550-7	2000	MRP4 overexpression is associated with high-level resistance to the nucleoside analogues 9-(2-phosphonylmethoxyethyl) adenine and azidothymidine, both of which are used as anti-human immunodeficiency virus drugs.	Nucleosides	68-78	ATP binding cassette subfamily C member 4	Homo sapiens	0-4
10880764-1	2000	Deoxycytidine kinase (dCK) mediates the phosphorylation of nucleoside analogues that can be used as anti-cancer agents.	Nucleosides	59-69	deoxycytidine kinase	Homo sapiens	0-20
10880764-1	2000	Deoxycytidine kinase (dCK) mediates the phosphorylation of nucleoside analogues that can be used as anti-cancer agents.	Nucleosides	59-69	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
10945628-4	2000	Because poly(ADP-ribose) polymerase (PARP)-mediated NAD+/ATP depletion has been implicated in the nucleoside-induced killing of normal resting lymphocytes, we postulated that this mechanism might account for the p53-independent component of nucleoside cytotoxicity in CLL.	Nucleosides	98-108	poly(ADP-ribose) polymerase 1	Homo sapiens	8-35
10966789-1	2000	In contrast to all known deoxyribonucleoside kinases, a single highly efficient deoxyribonucleoside kinase from Drosophila melanogaster (Dm-dNK) is able to phosphorylate all precursor nucleosides for DNA synthesis.	Nucleosides	184-195	deoxyribonucleoside kinase	Drosophila melanogaster	137-143
10945628-4	2000	Because poly(ADP-ribose) polymerase (PARP)-mediated NAD+/ATP depletion has been implicated in the nucleoside-induced killing of normal resting lymphocytes, we postulated that this mechanism might account for the p53-independent component of nucleoside cytotoxicity in CLL.	Nucleosides	98-108	poly(ADP-ribose) polymerase 1	Homo sapiens	37-41
10945628-3	2000	Whereas p53 can contribute to the nucleoside-induced killing of CLL cells, recent work from this laboratory and elsewhere has shown that such killing can also occur by p53-independent mechanisms.	Nucleosides	34-44	tumor protein p53	Homo sapiens	8-11
10945628-4	2000	Because poly(ADP-ribose) polymerase (PARP)-mediated NAD+/ATP depletion has been implicated in the nucleoside-induced killing of normal resting lymphocytes, we postulated that this mechanism might account for the p53-independent component of nucleoside cytotoxicity in CLL.	Nucleosides	98-108	tumor protein p53	Homo sapiens	212-215
10945628-4	2000	Because poly(ADP-ribose) polymerase (PARP)-mediated NAD+/ATP depletion has been implicated in the nucleoside-induced killing of normal resting lymphocytes, we postulated that this mechanism might account for the p53-independent component of nucleoside cytotoxicity in CLL.	Nucleosides	241-251	poly(ADP-ribose) polymerase 1	Homo sapiens	37-41
10945628-4	2000	Because poly(ADP-ribose) polymerase (PARP)-mediated NAD+/ATP depletion has been implicated in the nucleoside-induced killing of normal resting lymphocytes, we postulated that this mechanism might account for the p53-independent component of nucleoside cytotoxicity in CLL.	Nucleosides	241-251	tumor protein p53	Homo sapiens	212-215
10945628-10	2000	This indicates that PARP activity can occasionally be central to nucleoside-induced killing and that such PARP-mediated killing is p53 independent.	Nucleosides	65-75	poly(ADP-ribose) polymerase 1	Homo sapiens	20-24
10945628-10	2000	This indicates that PARP activity can occasionally be central to nucleoside-induced killing and that such PARP-mediated killing is p53 independent.	Nucleosides	65-75	tumor protein p53	Homo sapiens	131-134
10900034-3	2000	Purified NS2 bound nucleosides.	Nucleosides	19-30	NS2	Homo sapiens	9-12
10825466-9	2000	These findings suggest that protons, dTub, and TEA act at a common site on rOCT1, and that rOCT1 participates in the renal secretion of dTub and other nucleosides.	Nucleosides	151-162	solute carrier family 22 member 1	Rattus norvegicus	91-96
11015147-0	2000	Differences between women and men in adverse events and CD4+ responses to nucleoside analogue therapy for HIV infection.	Nucleosides	74-84	CD4 molecule	Homo sapiens	56-59
10929033-4	2000	Our results indicate that while caspase activity is required for nucleoside-induced poly(ADP-ribose) polymerase (PARP) cleavage and DNA fragmentation, other manifestations of cell death (mitochondrial depolarization, exposure of phosphatidyl serine, cell membrane disruption and cell shrinkage) are caspase independent.	Nucleosides	65-75	poly(ADP-ribose) polymerase 1	Homo sapiens	84-111
10961525-1	2000	Cellular cytoplasmatic thymidine kinase 1 (TK1) catalyzes the intracellular phosphorylation of anti-HIV-1 nucleoside analogs zidovudine (AZT) and stavudine (d4T) to the corresponding monophosphate form.	Nucleosides	106-116	thymidine kinase 1	Homo sapiens	23-41
10961525-1	2000	Cellular cytoplasmatic thymidine kinase 1 (TK1) catalyzes the intracellular phosphorylation of anti-HIV-1 nucleoside analogs zidovudine (AZT) and stavudine (d4T) to the corresponding monophosphate form.	Nucleosides	106-116	thymidine kinase 1	Homo sapiens	43-46
10891116-3	2000	The results revealed a strict structural requirement for the nucleoside-mediated enhancement of IL-4.	Nucleosides	61-71	interleukin 4	Homo sapiens	96-100
10891116-6	2000	Of the few nucleoside analogues that demonstrated enhancement on Type 2 cytokine production, 7-(beta-D-ribofuranosyl)pyrrolo[2, 3-d]-4-pyrimidone-5-carboxamidine (16c) showed a dramatic enhancement (>200%) of IL-4 levels and a significant enhancement (36%) of IL-5 levels.	Nucleosides	11-21	interleukin 4	Homo sapiens	212-216
10891116-6	2000	Of the few nucleoside analogues that demonstrated enhancement on Type 2 cytokine production, 7-(beta-D-ribofuranosyl)pyrrolo[2, 3-d]-4-pyrimidone-5-carboxamidine (16c) showed a dramatic enhancement (>200%) of IL-4 levels and a significant enhancement (36%) of IL-5 levels.	Nucleosides	11-21	interleukin 5	Homo sapiens	263-267
10799656-2	2000	Because of the overlap of its substrate specificity with that of the cytosolic thymidine kinase (TK1) and deoxycytidine kinase (dCK), it has been difficult to determine the role of TK2 in activating nucleosides used in chemotherapy.	Nucleosides	199-210	thymidine kinase 2	Homo sapiens	181-184
10799656-3	2000	In this report, we described the construction of a recombinant Escherichia coli strain which could be used to test if TK2 activity is limiting for the toxicity of nucleosides.	Nucleosides	163-174	thymidine kinase 2	Homo sapiens	118-121
10799656-9	2000	These results demonstrate that activation of growth-inhibiting pyrimidine nucleosides can be catalyzed by TK2, and together with recombinant E. coli strains expressing other cellular nucleoside kinases, this whole-cell bacterial system may serve as a tool to predict the efficacy and side effects of chemotherapeutic nucleosides.	Nucleosides	74-85	thymidine kinase 2	Homo sapiens	106-109
10884027-7	2000	Since ZMP was a good substrate of 5"-nucleotidase producing Z-riboside, we incubated murine and human cultured neuronal cells with this nucleoside and found that it is toxic for our models, promoting apoptosis.	Nucleosides	136-146	5'-nucleotidase, cytosolic IB	Mus musculus	34-49
10929033-4	2000	Our results indicate that while caspase activity is required for nucleoside-induced poly(ADP-ribose) polymerase (PARP) cleavage and DNA fragmentation, other manifestations of cell death (mitochondrial depolarization, exposure of phosphatidyl serine, cell membrane disruption and cell shrinkage) are caspase independent.	Nucleosides	65-75	poly(ADP-ribose) polymerase 1	Homo sapiens	113-117
10874216-0	2000	Human T cell leukemia cell death by apoptosis-inducing nucleosides from CD57(+) HLA-DR(bright) natural suppressor cell line.	Nucleosides	55-66	beta-1,3-glucuronyltransferase 1	Homo sapiens	72-76
10874216-1	2000	Apoptosis-inducing nucleosides (AINs) released from CD57( +) HLA-DR(bright) natural suppressor (57.DR-NS) cell line, derived from human decidual tissue, were isolated from 57.DR-NS cell culture supernatant by the combination of thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC).	Nucleosides	19-30	beta-1,3-glucuronyltransferase 1	Homo sapiens	52-56
10901289-7	2000	Thus, cellular deoxycytidine kinase has a considerably relaxed enantioselectivity with respect to a large number of nucleosides or their analogues, and it occupies a strategic position in the intracellular activation of the compounds.	Nucleosides	116-127	deoxycytidine kinase	Homo sapiens	15-35
10864043-2	2000	In this study, we have identified and characterized the TRM2 gene that encodes the tRNA(m5U54)methyltransferase, responsible for the formation of this modified nucleoside in Saccharomyces cerevisiae.	Nucleosides	160-170	tRNA (uracil(54)-C(5))-methyltransferase	Saccharomyces cerevisiae S288C	56-60
10775324-4	2000	In contrast, methylated nucleosides (base adducts) were stable in the presence of cob(I)alamin.	Nucleosides	24-35	metabolism of cobalamin associated B	Homo sapiens	82-85
10815900-5	2000	High levels of XIAP protein in tumor cell lines were unexpectedly correlated with sensitivity to some anticancer drugs, particularly cytarabine and other nucleosides, whereas higher levels of cIAP1 protein levels were associated with resistance to several anticancer drugs.	Nucleosides	154-165	X-linked inhibitor of apoptosis	Homo sapiens	15-19
10893714-2	2000	Dinucleoside phosphite triester intermediates were obtained in one-pot synthesis by the coupling of a protected nucleoside bearing free 5"-OH and a protected nucleoside bearing free 3"-OH in the presence of phosphorous trichloride (PCl3) and 1,2,4-triazole.	Nucleosides	2-12	PHD finger protein 19	Homo sapiens	232-236
10864003-3	2000	Mutation of a putative nucleotide binding site identified at the predicted extracellular mouth of the ICln channel protein leads to the reduction of the nucleoside-analogue sensitivity.	Nucleosides	153-163	chloride nucleotide-sensitive channel 1A pseudogene 1	Homo sapiens	102-106
10816823-2	2000	It was shown that PLA2 deacetylates the glycerol residue at position 2, PLC is inactive, and PLD hydrolyzes the phosphatidylnucleosides to give free nucleosides.	Nucleosides	124-135	phospholipase A2 group IB	Homo sapiens	18-22
10684932-1	2000	The TPsiC stem and loop (TSL) of tRNA contains highly conserved nucleoside modifications, m(5)C(49), T(54), Psi(55)and m(1)A(58).	Nucleosides	64-74	TSL	Homo sapiens	25-28
10816823-2	2000	It was shown that PLA2 deacetylates the glycerol residue at position 2, PLC is inactive, and PLD hydrolyzes the phosphatidylnucleosides to give free nucleosides.	Nucleosides	124-135	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	93-96
10810448-0	2000	Maintenance of differential methotrexate toxicity between cells expressing drug-resistant and wild-type dihydrofolate reductase activities in the presence of nucleosides through nucleoside transport inhibition.	Nucleosides	158-169	dihydrofolate reductase	Homo sapiens	104-127
10692168-3	2000	We have shown that the intracellular concentration of the virulence-related transcriptional regulator VirF is reduced in the absence of either of these modified nucleosides.	Nucleosides	161-172	VirF	Shigella flexneri	102-106
10679236-0	2000	Activation of caspase-3 in molt4 cells by apoptosis-inducing nucleosides from CD57(+)HLA-DR(bright) natural suppressor cell line.	Nucleosides	61-72	caspase 3	Homo sapiens	14-23
10679236-0	2000	Activation of caspase-3 in molt4 cells by apoptosis-inducing nucleosides from CD57(+)HLA-DR(bright) natural suppressor cell line.	Nucleosides	61-72	beta-1,3-glucuronyltransferase 1	Homo sapiens	78-82
10679236-1	2000	Apoptosis-inducing nucleosides (AINs), which were released and isolated from CD57(+)HLA-DR(bright) natural suppressor (57.DR-NS) cell line derived from human decidual tissue, induced apoptosis in Molt4 cells.	Nucleosides	19-30	beta-1,3-glucuronyltransferase 1	Homo sapiens	77-81
10609556-1	2000	The nucleoside analogue cordycepin (3"-deoxyadenosine, 3"-dA) is substantially more cytotoxic to terminal deoxynucleotidyl transferase positive (TdT+) leukemic cells than to TdT leukemic cells in vitro in the presence of an adenosine deaminase inhibitor, deoxycoformycin (dCF), and has been considered as a therapeutic agent for TdT+ leukemia.	Nucleosides	4-14	DNA nucleotidylexotransferase	Homo sapiens	145-148
10609556-1	2000	The nucleoside analogue cordycepin (3"-deoxyadenosine, 3"-dA) is substantially more cytotoxic to terminal deoxynucleotidyl transferase positive (TdT+) leukemic cells than to TdT leukemic cells in vitro in the presence of an adenosine deaminase inhibitor, deoxycoformycin (dCF), and has been considered as a therapeutic agent for TdT+ leukemia.	Nucleosides	4-14	DNA nucleotidylexotransferase	Homo sapiens	174-177
10810448-4	2000	Here we have investigated conditions under which nucleoside transport inhibition can be used to maintain differential MTX toxicity between unmodified cells and cells expressing drug-resistant DHFR activity in the presence of exogenous nucleosides.	Nucleosides	49-59	dihydrofolate reductase	Homo sapiens	192-196
10606241-7	1999	The specific activity of the nucleoside phosphorylating enzyme (using deoxycytidine as substrate) in cell extracts from HL60/CdA and HL60/Fara-A mutants was about 10 and 60%, respectively, compared with the parental cell line.	Nucleosides	29-39	cytidine deaminase	Homo sapiens	125-128
10774592-0	2000	Susceptibility of protein kinase (ORF47)-deficient varicella-zoster virus strains to anti-herpesvirus nucleosides.	Nucleosides	102-113	tegument serine/threonine protein kinase	Human alphaherpesvirus 3	34-39
10774592-1	2000	To clarify whether varicella-zoster virus (VZV) protein kinase (PK; ORF47) takes part in phosphorylation of anti-herpesvirus nucleosides, thymidine kinase (TK) deficient, and PK/TK double deficient recombinant VZV strains were isolated and their susceptibility, and that of wild type and PK-deficient strains to various nucleoside analogs was evaluated.	Nucleosides	125-135	tegument serine/threonine protein kinase	Human alphaherpesvirus 3	68-73
20016809-1	1999	We describe the preparation and fluorescence properties of a set of new nucleosides in which a known hydrocarbon or oligothiophene fluorophore replaces the DNA base at C(1) of the deoxyribose moiety (see 3a - f).	Nucleosides	72-83	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	168-172
10772724-0	2000	Differential transport of cytosine-containing nucleosides by recombinant human concentrative nucleoside transporter protein hCNT1.	Nucleosides	46-57	solute carrier family 28 member 1	Homo sapiens	124-129
10772724-1	2000	The transportability of cytosine-containing nucleosides by recombinant hCNT1 was investigated in transfected mammalian cells.	Nucleosides	44-55	solute carrier family 28 member 1	Homo sapiens	71-76
10772725-6	2000	The hypothesis on an important role of the 3"-to-5" exonuclease activity of p53 protein in the action of nucleoside analogs was proposed.	Nucleosides	105-115	tumor protein p53	Homo sapiens	76-79
10600122-3	1999	We find that the -1 phosphate and -2 nucleoside on the scissile strand (5"-CCCTTp / NpN) enhance the rate of transesterification by factors of 40 and 25, respectively, whereas the DNA segment downstream of the -2 nucleotide makes no significant kinetic contribution.	Nucleosides	37-47	nephrocan, pseudogene	Homo sapiens	84-87
10531572-1	1999	BACKGROUND: Previous reports have suggested activity of the nucleoside analogues 2-chlorodeoxyadenosine (2-CdA) and 2"-deoxycoformycin (2"-DCF) in Langerhans cell histiocytosis (LCH).	Nucleosides	60-70	cytidine deaminase	Homo sapiens	107-110
10674004-0	1999	Treatment of normal and malignant cells with nucleoside analogues and etoposide enhances deoxycytidine kinase activity.	Nucleosides	45-55	deoxycytidine kinase	Homo sapiens	89-109
10613357-3	1999	In our methylcellulose assays, the nucleoside analogs cladribine (2-CdA) and gemcitabine (dFdC) showed more prominent inhibitory effects on CML than normal bone marrow (BM) progenitors.	Nucleosides	35-45	cytidine deaminase	Homo sapiens	68-71
10656876-0	1999	Modulation of nucleoside [correction of nucleotide] triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection.	Nucleosides	14-24	ectonucleoside triphosphate diphosphohydrolase 1	Rattus norvegicus	87-96
10656876-0	1999	Modulation of nucleoside [correction of nucleotide] triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection.	Nucleosides	14-24	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	97-101
10656876-2	1999	Nucleoside [corrected] triphosphate diphosphohydrolase-1 (NTPDase-1, identical to CD39), the major vascular endothelial ectonucleotidase, is responsible for the hydrolysis of both extracellular ATP and ADP in the blood plasma to AMP.	Nucleosides	0-10	ectonucleoside triphosphate diphosphohydrolase 1	Rattus norvegicus	58-67
10656876-2	1999	Nucleoside [corrected] triphosphate diphosphohydrolase-1 (NTPDase-1, identical to CD39), the major vascular endothelial ectonucleotidase, is responsible for the hydrolysis of both extracellular ATP and ADP in the blood plasma to AMP.	Nucleosides	0-10	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	82-86
10529018-1	1999	The antitumor activity of a novel nucleoside, 1-(2-deoxy-2-fluoro-4-thio-beta-D arabinofuranosyl)cytosine (4"-thio-FAC) was compared with that of 2"-deoxy-2",2"-difluorocytidine (gemcitabine).	Nucleosides	34-44	FA complementation group C	Homo sapiens	115-118
10571069-1	1999	Phosphorylation of anti-viral nucleoside analogs by mitochondrial thymidine kinase 2 (TK2) has been implicated as a mechanism for the mitochondrial toxicity caused by several of these compounds.	Nucleosides	30-40	thymidine kinase 2, mitochondrial	Mus musculus	66-84
10571069-1	1999	Phosphorylation of anti-viral nucleoside analogs by mitochondrial thymidine kinase 2 (TK2) has been implicated as a mechanism for the mitochondrial toxicity caused by several of these compounds.	Nucleosides	30-40	thymidine kinase 2, mitochondrial	Mus musculus	86-89
10571069-3	1999	This is the first report on the cloning of a mitochondrial TK2 and will contribute to elucidate the role of TK2 in the pharmacological activation of nucleoside analogs.	Nucleosides	149-159	thymidine kinase 2, mitochondrial	Mus musculus	59-62
10571069-3	1999	This is the first report on the cloning of a mitochondrial TK2 and will contribute to elucidate the role of TK2 in the pharmacological activation of nucleoside analogs.	Nucleosides	149-159	thymidine kinase 2, mitochondrial	Mus musculus	108-111
10499616-7	1999	The relative efficacy of CAFdA as a substrate for purified recombinant deoxycytidine kinase (dCK), the key enzyme in the activation of nucleoside analogues, was very high and exceeded that of CdA as well as the natural substrate, deoxycytidine, by a factor of 2 and 8, respectively.	Nucleosides	135-145	deoxycytidine kinase	Homo sapiens	71-91
10519401-1	1999	Mouse transporter protein (MTP), a small, highly conserved mammalian intracellular membrane protein with four putative transmembrane domains, has been implicated in the transport of nucleosides and/or related molecules across intracellular membranes.	Nucleosides	182-193	microsomal triglyceride transfer protein	Homo sapiens	0-25
10519401-1	1999	Mouse transporter protein (MTP), a small, highly conserved mammalian intracellular membrane protein with four putative transmembrane domains, has been implicated in the transport of nucleosides and/or related molecules across intracellular membranes.	Nucleosides	182-193	microsomal triglyceride transfer protein	Homo sapiens	27-30
10480908-5	1999	We have used hydroxyl radical footprinting, missing nucleoside, and methylation interference experiments to investigate the structure of the complex of the DNA binding domain of Mac1 (called here Mac1(t)) with the two CuRE sites found in the yeast CTR1 promoter.	Nucleosides	52-62	Mac1p	Saccharomyces cerevisiae S288C	178-182
10480908-5	1999	We have used hydroxyl radical footprinting, missing nucleoside, and methylation interference experiments to investigate the structure of the complex of the DNA binding domain of Mac1 (called here Mac1(t)) with the two CuRE sites found in the yeast CTR1 promoter.	Nucleosides	52-62	Mac1p	Saccharomyces cerevisiae S288C	196-203
10520012-2	1999	Cases of CLL with p53 dysfunction (n = 7) displayed slight, but significant, resistance to nucleoside-induced cell killing when compared with cases with functionally intact p53 (n = 12).	Nucleosides	91-101	tumor protein p53	Homo sapiens	18-21
10520012-4	1999	These findings suggest that the poor therapeutic response to purine analogues observed in patients with p53 defects is likely to be caused by the emergence, on a background of genomic instability, of CLL-cell clones that are resistant to nucleoside-induced killing for reasons unrelated to p53.	Nucleosides	238-248	tumor protein p53	Homo sapiens	104-107
10499616-7	1999	The relative efficacy of CAFdA as a substrate for purified recombinant deoxycytidine kinase (dCK), the key enzyme in the activation of nucleoside analogues, was very high and exceeded that of CdA as well as the natural substrate, deoxycytidine, by a factor of 2 and 8, respectively.	Nucleosides	135-145	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	93-96
10499616-9	1999	Acquired resistance to CAFdA in HL60 and in CCRF-CEM cell lines was directly correlated to the decreased activity of the nucleoside phosphorylating enzyme, dCK.	Nucleosides	121-131	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	156-159
10446143-1	1999	A Drosophila melanogaster deoxyribonucleoside kinase (Dm-dNK) was reported to phosphorylate all four natural deoxyribonucleosides as well as several nucleoside analogs (Munch-Petersen, B., Piskur, J., and Sondergaard, L. (1998) J. Biol.	Nucleosides	35-45	deoxyribonucleoside kinase	Drosophila melanogaster	54-60
10455183-3	1999	In this work, using a combination of oocyte microinjection, electrophoretic mobility shift assays, and missing nucleoside experiments with wild-type and mutant promoters, we demonstrate that the hU6 gene requires zinc fingers 2-7 for Staf binding and Oct-1 for maximal transcriptional activity.	Nucleosides	111-121	RNA, U6 small nuclear 1	Homo sapiens	195-198
10463941-1	1999	Of all of the nucleoside inhibitors approved by the FDA for treatment of AIDS, (-)-beta-2",3"-dideoxy-3"-thiacytidine (3TC, lamivudine) is the only one with the unnatural (-)-beta-L configuration.	Nucleosides	14-24	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	83-89
10470083-0	1999	MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs.	Nucleosides	56-66	ATP binding cassette subfamily C member 4	Homo sapiens	0-4
10470083-7	1999	Overexpression of MRP4 mRNA and MRP4 protein severely impaired the antiviral efficacy of PMEA, azidothymidine and other nucleoside analogs.	Nucleosides	120-130	ATP binding cassette subfamily C member 4	Homo sapiens	18-22
10470083-7	1999	Overexpression of MRP4 mRNA and MRP4 protein severely impaired the antiviral efficacy of PMEA, azidothymidine and other nucleoside analogs.	Nucleosides	120-130	ATP binding cassette subfamily C member 4	Homo sapiens	32-36
10455109-1	1999	hCNT1 and hCNT2 mediate concentrative (Na(+)-linked) cellular uptake of nucleosides and nucleoside drugs by human cells and tissues.	Nucleosides	72-83	solute carrier family 28 member 1	Homo sapiens	0-5
10455109-1	1999	hCNT1 and hCNT2 mediate concentrative (Na(+)-linked) cellular uptake of nucleosides and nucleoside drugs by human cells and tissues.	Nucleosides	72-83	solute carrier family 28 member 2	Homo sapiens	10-15
10455109-1	1999	hCNT1 and hCNT2 mediate concentrative (Na(+)-linked) cellular uptake of nucleosides and nucleoside drugs by human cells and tissues.	Nucleosides	72-82	solute carrier family 28 member 1	Homo sapiens	0-5
10455109-1	1999	hCNT1 and hCNT2 mediate concentrative (Na(+)-linked) cellular uptake of nucleosides and nucleoside drugs by human cells and tissues.	Nucleosides	72-82	solute carrier family 28 member 2	Homo sapiens	10-15
10455109-6	1999	Mutation of Ser(319) in TM 7 of hCNT1 to Gly enabled transport of purine nucleosides, whereas concurrent mutation of Gln(320) to Met (which had no effect on its own) augmented this transport.	Nucleosides	73-84	solute carrier family 28 member 1	Homo sapiens	32-37
10446143-5	1999	We have in the present study cloned the Dm-dNK cDNA, expressed the 29-kDa protein in Escherichia coli, and characterized the recombinant enzyme for the phosphorylation of nucleosides and clinically important nucleoside analogs.	Nucleosides	171-182	deoxyribonucleoside kinase	Drosophila melanogaster	40-46
10446143-5	1999	We have in the present study cloned the Dm-dNK cDNA, expressed the 29-kDa protein in Escherichia coli, and characterized the recombinant enzyme for the phosphorylation of nucleosides and clinically important nucleoside analogs.	Nucleosides	171-181	deoxyribonucleoside kinase	Drosophila melanogaster	40-46
10423569-2	1999	The nucleosides 2"-deoxycytidine, thymidine, 2"-deoxyadenosine, 2"-deoxyguanosine, cytidine, adenosine and guanosine form 1 : 1 and 2 : 1 adducts with [Cr(salprn)](+), whereas the dinucleotides CpG, GpC, ApT, TpA and TpC form only the 1 : 1 adducts.	Nucleosides	4-15	glycophorin C (Gerbich blood group)	Homo sapiens	199-202
10423569-2	1999	The nucleosides 2"-deoxycytidine, thymidine, 2"-deoxyadenosine, 2"-deoxyguanosine, cytidine, adenosine and guanosine form 1 : 1 and 2 : 1 adducts with [Cr(salprn)](+), whereas the dinucleotides CpG, GpC, ApT, TpA and TpC form only the 1 : 1 adducts.	Nucleosides	4-15	LYPLA2 pseudogene 1	Homo sapiens	204-207
10336543-2	1999	With the recent cloning of a purine-selective, Na+-dependent, nucleoside transporter (hSPNT1, also termed hCNT2) from human kidney, it is now possible to study the interaction of nucleosides and nucleoside analogs with this transport protein and gain a more detailed knowledge of the underlying mechanisms of nucleoside transport in the human kidney.	Nucleosides	179-190	solute carrier family 28 member 2	Homo sapiens	86-92
10478487-0	1999	Substrate/inhibitor properties of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) towards the sugar moiety of nucleosides, including O"-alkyl analogues.	Nucleosides	131-142	deoxycytidine kinase	Homo sapiens	40-60
10478487-0	1999	Substrate/inhibitor properties of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) towards the sugar moiety of nucleosides, including O"-alkyl analogues.	Nucleosides	131-142	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	62-65
10478487-0	1999	Substrate/inhibitor properties of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) towards the sugar moiety of nucleosides, including O"-alkyl analogues.	Nucleosides	131-142	thymidine kinase 1	Homo sapiens	90-93
10478487-0	1999	Substrate/inhibitor properties of human deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) towards the sugar moiety of nucleosides, including O"-alkyl analogues.	Nucleosides	131-142	thymidine kinase 2	Homo sapiens	98-101
10478487-1	1999	Nucleoside analogues with modified sugar moieties have been examined for their substrate/inhibitor specificities towards highly purified deoxycytidine kinase (dCK) and thymidine kinases (tetrameric high-affinity form of TK1, and TK2) from human leukemic spleen.	Nucleosides	0-10	deoxycytidine kinase	Homo sapiens	137-157
10478487-1	1999	Nucleoside analogues with modified sugar moieties have been examined for their substrate/inhibitor specificities towards highly purified deoxycytidine kinase (dCK) and thymidine kinases (tetrameric high-affinity form of TK1, and TK2) from human leukemic spleen.	Nucleosides	0-10	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	159-162
10478487-1	1999	Nucleoside analogues with modified sugar moieties have been examined for their substrate/inhibitor specificities towards highly purified deoxycytidine kinase (dCK) and thymidine kinases (tetrameric high-affinity form of TK1, and TK2) from human leukemic spleen.	Nucleosides	0-10	thymidine kinase 1	Homo sapiens	220-223
10397538-8	1999	CONCLUSIONS: These results show that early therapy with nucleoside analogues can correct the immunological abnormalities observed in CD4 and CD8 T cell subsets at the time of PHI.	Nucleosides	56-66	CD4 molecule	Homo sapiens	133-136
10397538-8	1999	CONCLUSIONS: These results show that early therapy with nucleoside analogues can correct the immunological abnormalities observed in CD4 and CD8 T cell subsets at the time of PHI.	Nucleosides	56-66	CD8a molecule	Homo sapiens	141-144
10477169-8	1999	A critical finding is that the antimitotic H10 is a bifunctional anticancer drug, which also blocks the cellular transport of nucleosides (IC50: 6 microM) to inhibit DNA synthesis.	Nucleosides	126-137	histocompatibility 10	Mus musculus	43-46
10357788-1	1999	In this study, we developed a quantitative isotope dilution method for analysis of N-(deoxyguanosine-8-yl)-4-aminobiphenyl (dG-C8-4-ABP), the principal nucleoside adduct derived from enzymatic hydrolysis of 4-aminobiphenyl (4-ABP)-modified DNA.	Nucleosides	152-162	amine oxidase, copper-containing 1	Mus musculus	132-135
10371571-13	1999	INTERPRETATION: Subcutaneous interleukin-2 is a convenient regimen that, as well as intravenous therapy, improves immunological function in HIV-1-infected patients receiving two nucleosides.	Nucleosides	178-189	interleukin 2	Homo sapiens	29-42
10554810-2	1999	p53-knockout cells were more resistant to all three nucleosides than were wild-type cells.	Nucleosides	52-63	transformation related protein 53, pseudogene	Mus musculus	0-3
10554810-4	1999	We suggest that these results are relevant to chronic lymphoid malignancies, and that characterization of the p53-independent component of nucleoside action may indicate potential ways of overcoming therapeutic resistance.	Nucleosides	139-149	transformation related protein 53, pseudogene	Mus musculus	110-113
10336543-2	1999	With the recent cloning of a purine-selective, Na+-dependent, nucleoside transporter (hSPNT1, also termed hCNT2) from human kidney, it is now possible to study the interaction of nucleosides and nucleoside analogs with this transport protein and gain a more detailed knowledge of the underlying mechanisms of nucleoside transport in the human kidney.	Nucleosides	179-190	solute carrier family 28 member 2	Homo sapiens	106-111
10336543-2	1999	With the recent cloning of a purine-selective, Na+-dependent, nucleoside transporter (hSPNT1, also termed hCNT2) from human kidney, it is now possible to study the interaction of nucleosides and nucleoside analogs with this transport protein and gain a more detailed knowledge of the underlying mechanisms of nucleoside transport in the human kidney.	Nucleosides	62-72	solute carrier family 28 member 2	Homo sapiens	86-92
10336543-2	1999	With the recent cloning of a purine-selective, Na+-dependent, nucleoside transporter (hSPNT1, also termed hCNT2) from human kidney, it is now possible to study the interaction of nucleosides and nucleoside analogs with this transport protein and gain a more detailed knowledge of the underlying mechanisms of nucleoside transport in the human kidney.	Nucleosides	62-72	solute carrier family 28 member 2	Homo sapiens	106-111
10336543-2	1999	With the recent cloning of a purine-selective, Na+-dependent, nucleoside transporter (hSPNT1, also termed hCNT2) from human kidney, it is now possible to study the interaction of nucleosides and nucleoside analogs with this transport protein and gain a more detailed knowledge of the underlying mechanisms of nucleoside transport in the human kidney.	Nucleosides	179-189	solute carrier family 28 member 2	Homo sapiens	86-92
10336543-2	1999	With the recent cloning of a purine-selective, Na+-dependent, nucleoside transporter (hSPNT1, also termed hCNT2) from human kidney, it is now possible to study the interaction of nucleosides and nucleoside analogs with this transport protein and gain a more detailed knowledge of the underlying mechanisms of nucleoside transport in the human kidney.	Nucleosides	179-189	solute carrier family 28 member 2	Homo sapiens	106-111
10336543-3	1999	In this study we examined the substrate selectivity of hSPNT1 for nucleosides and nucleoside analogs.	Nucleosides	66-77	solute carrier family 28 member 2	Homo sapiens	55-61
10336543-3	1999	In this study we examined the substrate selectivity of hSPNT1 for nucleosides and nucleoside analogs.	Nucleosides	66-76	solute carrier family 28 member 2	Homo sapiens	55-61
10096558-0	1999	A novel, orally administered nucleoside analogue, OGT 719, inhibits the liver invasive growth of a human colorectal tumor, C170HM2.	Nucleosides	29-39	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	50-53
10474235-0	1999	Nucleoside modifications affect the structure and stability of the anticodon of tRNA(Lys,3).	Nucleosides	0-10	mitochondrially encoded tRNA glycine	Homo sapiens	80-90
10381636-5	1999	Therapy with nelfinavir plus saquinavir in combination with two nucleoside analogue inhibitors of reverse transcriptase dramatically reduces plasma viremia and increases CD4 T cell counts.	Nucleosides	64-74	CD4 molecule	Homo sapiens	170-173
10213491-0	1999	S-adenosylmethionine synthetase is overexpressed in murine neuroblastoma cells resistant to nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase: a novel mechanism of drug resistance.	Nucleosides	92-102	S-adenosylhomocysteine hydrolase	Mus musculus	126-158
10213491-4	1999	In the present study, immunoblot analyses of AdoMet Synthetase with isoform-specific (MATII) antibodies demonstrated an elevation in the AdoMet synthetase immunoprotein in nucleoside analogue-resistant MNB cells (rMNB-MDL) when compared to wild-type, nonresistant MNB cells.	Nucleosides	172-182	methionine adenosyltransferase 2A	Homo sapiens	86-91
10213491-10	1999	The resistance of rMNB-MDL cells to nucleoside analogue inhibitors of S-adenosylhomocysteine hydrolase correlates directly with overexpression of the alpha2/alpha2" subunits of AdoMet synthetase.	Nucleosides	36-46	adenosylhomocysteinase	Homo sapiens	70-102
10432672-0	1999	Synthesis of new fluorescent nucleoside analogues and application to the study of human deoxycytidine kinase.	Nucleosides	29-39	deoxycytidine kinase	Homo sapiens	88-108
10221532-1	1999	This study investigated the effects of a combination antiretroviral drug regimen (indinavir and two nucleoside analogs or ritonavir and saquinavir) on the levels of CD34+ colony-forming units (CFU-Cs) in the peripheral blood of HIV-1+ patients.	Nucleosides	100-110	CD34 molecule	Homo sapiens	165-169
10087315-0	1999	Apoptotic cell death of human gastric tumor induced by nucleosides from CD57+HLA-DRbright natural suppressor cell line.	Nucleosides	55-66	beta-1,3-glucuronyltransferase 1	Homo sapiens	72-76
10598557-4	1999	Dipyridamole inhibits nucleoside transport and in vitro studies have demonstrated that dipyridamole can prevent thymidine salvage rescue from antifolate thymidylate synthase inhibitors.	Nucleosides	22-32	thymidylate synthetase	Homo sapiens	153-173
10349744-7	1999	Influence of the structural features of the cap-analogues, especially the type of the second nucleoside in the dinucleotide caps, on their association with eIF4E and biological activities in in vitro protein translation systems has been discussed in light of the known structures of the eIF4E-7-methyl-GDP complexes in crystal and solution.	Nucleosides	93-103	eukaryotic translation initiation factor 4E	Homo sapiens	156-161
10064603-5	1999	Tat-stimulated elongation is strongly inhibited by the nucleoside analogue 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB), which inhibits the Tat-associated kinase, TAK (CDK9).	Nucleosides	55-65	cyclin dependent kinase 9	Homo sapiens	178-182
11674219-7	1999	The resulting modified nucleosides should facilitate the study of C-3"-DNA radicals.	Nucleosides	23-34	complement C3	Homo sapiens	66-69
10344069-4	1999	The results from prolonged follow-up of this study are eagerly awaited but it is clear that a combination of efavirenz with nucleoside analogues provides a potent proteinase inhibitor-sparing regimen which may have less toxicity.	Nucleosides	124-134	endogenous retrovirus group K member 25	Homo sapiens	163-173
10037238-2	1999	The Fab phage display library was constructed from hybridoma cells producing APU-6 MoAb specific for a modified nucleoside, pseudouridine that have been studied as a urinary marker for malignancy.	Nucleosides	112-122	FA complementation group B	Homo sapiens	4-7
10100299-0	1999	"5"-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter,".	Nucleosides	35-46	solute carrier family 15 member 1	Homo sapiens	98-103
9917387-4	1999	A unique missing nucleoside at the downstream end of the TATA box, corresponding to the position of one of two TBP-mediated DNA kinks, significantly enhances TBP-DNA complex formation.	Nucleosides	17-27	TATA-binding protein	Saccharomyces cerevisiae S288C	111-114
9917387-4	1999	A unique missing nucleoside at the downstream end of the TATA box, corresponding to the position of one of two TBP-mediated DNA kinks, significantly enhances TBP-DNA complex formation.	Nucleosides	17-27	TATA-binding protein	Saccharomyces cerevisiae S288C	158-161
12731758-0	1999	Evolution of genotypic resistance to nucleoside analogues in patients receiving protease inhibitor-containing regimens.	Nucleosides	37-47	serpin family A member 13, pseudogene	Homo sapiens	80-98
9894020-4	1999	HPLC analyses following enzymatic hydrolysis to nucleosides indicated one major adduct, N-(deoxyguanosin-8-yl)-4-aminobiphenyl (dG-C8-4-ABP).	Nucleosides	48-59	amine oxidase, copper-containing 1	Mus musculus	136-139
9989599-0	1999	Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates.	Nucleosides	118-128	thymidine kinase 2	Homo sapiens	6-24
9989599-3	1999	We also characterised N-terminally truncated (starting at position 18) human TK2 with pharmacologically important antiviral and cytostatic nucleoside analogues.	Nucleosides	139-149	thymidine kinase 2	Homo sapiens	77-80
9989599-8	1999	The results demonstrate a broad substrate specificity and complex kinetics, and suggest a role for TK2 in the activation of chemotherapeutic nucleoside analogues.	Nucleosides	141-151	thymidine kinase 2	Homo sapiens	99-102
9887265-8	1999	These regions include the catalytically active site and the non-nucleoside inhibitor binding pocket of p66 polymerase, as well as sites whose mutations have been shown to impair enzyme activity.	Nucleosides	64-74	DNA polymerase delta 3, accessory subunit	Homo sapiens	103-106
9880091-7	1998	Risk factors for developing peripheral neuropathy during nucleoside analogue therapy include low CD4+ cell count (<100 cells/mm3), a prior history of an AIDS defining illness or neoplasm, a history of peripheral neuropathy, use of other neurotoxic agents including high alcohol (ethanol) consumption and nutritional deficiencies such as low serum hydroxocobalamin levels.	Nucleosides	57-67	CD4 molecule	Homo sapiens	97-100
10613591-2	1999	The resistance toward the enzyme cytidine-deaminase action was described as an characteristic feature of this synthetic nucleoside.	Nucleosides	120-130	cytidine deaminase	Homo sapiens	33-51
10780361-1	1999	Several nucleosides have been prepared as a possible inhibitor of human S-adenosyl-L-homocysteine (SAH) hydrolase for the development of anti-viral agents.	Nucleosides	8-19	acyl-CoA synthetase medium chain family member 3	Homo sapiens	72-97
10780361-1	1999	Several nucleosides have been prepared as a possible inhibitor of human S-adenosyl-L-homocysteine (SAH) hydrolase for the development of anti-viral agents.	Nucleosides	8-19	acyl-CoA synthetase medium chain family member 3	Homo sapiens	99-102
10780361-3	1999	We report synthesis of several nucleosides including carbocyclic nucleosides and their inhibitory activities against recombinant malaria and human SAH hydrolases.	Nucleosides	31-42	acyl-CoA synthetase medium chain family member 3	Homo sapiens	147-150
9804860-9	1998	These results provided evidence for the presence of functional es and ei transporters in nuclear membranes and endoplasmic reticulum, suggesting that hENT1 and hENT2 may function in the translocation of nucleosides between the cytosol and the luminal compartments of one or both of these membrane types.	Nucleosides	203-214	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	150-155
9804782-1	1998	Deoxycytidine kinase (dCK) catalyzes the rate-limiting step of the deoxynucleoside salvage pathway in mammalian cells and plays a key role in the activation of several pharmacologically important nucleoside analogs.	Nucleosides	72-82	deoxycytidine kinase	Homo sapiens	0-20
9804782-1	1998	Deoxycytidine kinase (dCK) catalyzes the rate-limiting step of the deoxynucleoside salvage pathway in mammalian cells and plays a key role in the activation of several pharmacologically important nucleoside analogs.	Nucleosides	72-82	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
9828213-7	1998	FAO cells induced to proliferate after serum refeeding show an increase in SPNT mRNA levels, which is followed by an increase in Na+-dependent nucleoside uptake and occurs before the peak of 3H-thymidine incorporation into DNA.	Nucleosides	143-153	solute carrier family 28 member 2	Rattus norvegicus	75-79
9804860-9	1998	These results provided evidence for the presence of functional es and ei transporters in nuclear membranes and endoplasmic reticulum, suggesting that hENT1 and hENT2 may function in the translocation of nucleosides between the cytosol and the luminal compartments of one or both of these membrane types.	Nucleosides	203-214	solute carrier family 29 member 2	Homo sapiens	160-165
9756942-0	1998	Regulation of nucleoside transport by lipopolysaccharide, phorbol esters, and tumor necrosis factor-alpha in human B-lymphocytes.	Nucleosides	14-24	tumor necrosis factor	Homo sapiens	78-105
9792789-0	1998	Isolation and identification of apoptosis inducing nucleosides from CD57(+)HLA-DRbright natural suppressor cell line.	Nucleosides	51-62	beta-1,3-glucuronyltransferase 1	Homo sapiens	68-72
9756942-6	1998	Interestingly, TNF-alpha down-regulates es activity, but this effect cannot be abolished by inhibiting protein kinase C. This study reveals differential regulation of nucleoside transport systems following activation of human B-lymphocyte cell lines by agents of physiological relevance such as TNF-alpha and LPS.	Nucleosides	167-177	tumor necrosis factor	Homo sapiens	15-24
9784109-4	1998	Conformational analysis of anhydrohexitol nucleosides using computational methods indicates that these nucleosides occur in an equilibrium between the C1 and 1C form with a DeltaE of 5.9 kJ/mol.	Nucleosides	42-53	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	151-160
9776315-1	1998	The kinetic properties of recombinant human mitochondrial deoxyguanosine kinase (dGK, EC 2.7.1.113) for 2"-deoxyguanosine and the clinically important nucleoside analogs 2-chloro-2"-deoxyadenosine (CdA), 9-beta-D-arabinofuranosylguanine (araG) and 2",2",-difluorodeoxyguanosine (dFdG) were determined.	Nucleosides	151-161	Diacyl glycerol kinase	Drosophila melanogaster	81-84
9756942-6	1998	Interestingly, TNF-alpha down-regulates es activity, but this effect cannot be abolished by inhibiting protein kinase C. This study reveals differential regulation of nucleoside transport systems following activation of human B-lymphocyte cell lines by agents of physiological relevance such as TNF-alpha and LPS.	Nucleosides	167-177	tumor necrosis factor	Homo sapiens	295-304
9755889-1	1998	PURPOSE: This study characterized the cellular uptake mechanism and hydrolysis of the amino acid ester prodrugs of nucleoside antiviral drugs in the transiently transfected Caco-2 cells overexpressing a human intestinal peptide transporter, hPEPT1 (Caco-2/hPEPT1 cells).	Nucleosides	115-125	solute carrier family 15 member 1	Homo sapiens	241-247
10087507-0	1998	Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine.	Nucleosides	155-166	solute carrier family 28 member 2	Homo sapiens	127-132
10087507-7	1998	In Xenopus oocytes, recombinant hCNT2 exhibited the functional characteristics of a Na(+)-dependent nucleoside transporter with selectivity for adenosine, other purine nucleosides and uridine (adenosine and uridine K(m) app values 8 and 40 microM, respectively).	Nucleosides	168-179	solute carrier family 28 member 2	Homo sapiens	32-37
10087507-10	1998	hCNT2 also mediated small, but significant, fluxes of the antiviral purine nucleoside analogue 2",3"-dideoxyinosine.	Nucleosides	75-85	solute carrier family 28 member 2	Homo sapiens	0-5
9726984-9	1998	Because activated AMPK phosphorylates and inactivates 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase (EC 1.1.1.88), the rate-limiting enzyme in cholesterol synthesis, the strong inhibition of hepatocytic cholesterol synthesis by all three nucleosides confirmed their ability to activate AMPK under the conditions used.	Nucleosides	243-254	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	18-22
9726984-9	1998	Because activated AMPK phosphorylates and inactivates 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase (EC 1.1.1.88), the rate-limiting enzyme in cholesterol synthesis, the strong inhibition of hepatocytic cholesterol synthesis by all three nucleosides confirmed their ability to activate AMPK under the conditions used.	Nucleosides	243-254	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	54-104
9726984-9	1998	Because activated AMPK phosphorylates and inactivates 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase (EC 1.1.1.88), the rate-limiting enzyme in cholesterol synthesis, the strong inhibition of hepatocytic cholesterol synthesis by all three nucleosides confirmed their ability to activate AMPK under the conditions used.	Nucleosides	243-254	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	291-295
9755889-1	1998	PURPOSE: This study characterized the cellular uptake mechanism and hydrolysis of the amino acid ester prodrugs of nucleoside antiviral drugs in the transiently transfected Caco-2 cells overexpressing a human intestinal peptide transporter, hPEPT1 (Caco-2/hPEPT1 cells).	Nucleosides	115-125	solute carrier family 15 member 1	Homo sapiens	256-262
9706043-0	1998	5"-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter.	Nucleosides	34-45	solute carrier family 15 member 1	Homo sapiens	97-102
9743553-9	1998	The inhibition of TNF-alpha production appeared to be mediated at least partly by PKC, since the nucleoside analogue caused suppression of PKC activity in stimulated cells.	Nucleosides	97-107	tumor necrosis factor	Homo sapiens	18-27
9706043-10	1998	CONCLUSIONS: This study demonstrates that L-amino acid-nucleoside chimeras can serve as prodrugs to enhance intestinal absorption via the PEPT1 transporter, providing a novel strategy for improving oral therapy of nucleoside drugs.	Nucleosides	55-65	solute carrier family 15 member 1	Homo sapiens	138-143
9706043-10	1998	CONCLUSIONS: This study demonstrates that L-amino acid-nucleoside chimeras can serve as prodrugs to enhance intestinal absorption via the PEPT1 transporter, providing a novel strategy for improving oral therapy of nucleoside drugs.	Nucleosides	214-224	solute carrier family 15 member 1	Homo sapiens	138-143
9614068-0	1998	Enhanced cytotoxicity of nucleoside analogs by overexpression of mitochondrial deoxyguanosine kinase in cancer cell lines.	Nucleosides	25-35	deoxyguanosine kinase	Homo sapiens	79-100
9636049-0	1998	Nucleotide and nucleoside analogues as inhibitors of cytosolic 5"-nucleotidase I from heart.	Nucleosides	15-25	5'-nucleotidase, cytosolic IA	Homo sapiens	53-80
9636049-9	1998	The most potent nucleotide and nucleoside inhibitor were both greater than 1000-fold more potent inhibiting c-N-I than the cytosolic 5"-nucleotidase II.	Nucleosides	31-41	5'-nucleotidase, cytosolic IA	Homo sapiens	108-113
9636049-10	1998	The nucleoside analogue was also greater than 1000-fold more potent against c-N-I than the membrane ecto-5"-nucleotidase (e-N).	Nucleosides	4-14	5'-nucleotidase, cytosolic IA	Homo sapiens	76-81
9636049-10	1998	The nucleoside analogue was also greater than 1000-fold more potent against c-N-I than the membrane ecto-5"-nucleotidase (e-N).	Nucleosides	4-14	5'-nucleotidase ecto	Homo sapiens	100-120
9636049-10	1998	The nucleoside analogue was also greater than 1000-fold more potent against c-N-I than the membrane ecto-5"-nucleotidase (e-N).	Nucleosides	4-14	5'-nucleotidase ecto	Homo sapiens	122-125
9636049-12	1998	Because of the high selectivity for c-N-I versus both of the other 5"-nucleotidases, the nucleoside inhibitors of c-N-I may be useful biochemical tools in discerning the role that c-N-I plays in generating adenosine within myocardium.	Nucleosides	89-99	5'-nucleotidase, cytosolic IA	Homo sapiens	36-41
9636049-12	1998	Because of the high selectivity for c-N-I versus both of the other 5"-nucleotidases, the nucleoside inhibitors of c-N-I may be useful biochemical tools in discerning the role that c-N-I plays in generating adenosine within myocardium.	Nucleosides	89-99	5'-nucleotidase, cytosolic IA	Homo sapiens	114-119
9636049-12	1998	Because of the high selectivity for c-N-I versus both of the other 5"-nucleotidases, the nucleoside inhibitors of c-N-I may be useful biochemical tools in discerning the role that c-N-I plays in generating adenosine within myocardium.	Nucleosides	89-99	5'-nucleotidase, cytosolic IA	Homo sapiens	114-119
9614068-2	1998	We overexpressed dGK as a fusion protein to the green fluorescent protein in the human pancreatic cancer cell lines PanC-1 and MIA PaCa-2 to determine the importance of dGK-mediated nucleoside analog phosphorylation.	Nucleosides	182-192	Diacyl glycerol kinase	Drosophila melanogaster	169-172
9614068-7	1998	Our data imply that the dGK activity is rate-limiting for the efficacy of nucleoside analogs in the cell lines investigated.	Nucleosides	74-84	Diacyl glycerol kinase	Drosophila melanogaster	24-27
9716390-11	1998	The present work contributes to a detailed understanding of nucleoside binding to TK, thereby facilitating the rational design of substrates for HSV1 TK and of drug-specific TK for gene therapy.	Nucleosides	60-70	involved in nucleotide metabolism	Human alphaherpesvirus 1	82-84
9716390-11	1998	The present work contributes to a detailed understanding of nucleoside binding to TK, thereby facilitating the rational design of substrates for HSV1 TK and of drug-specific TK for gene therapy.	Nucleosides	60-70	involved in nucleotide metabolism	Human alphaherpesvirus 1	150-152
9716390-11	1998	The present work contributes to a detailed understanding of nucleoside binding to TK, thereby facilitating the rational design of substrates for HSV1 TK and of drug-specific TK for gene therapy.	Nucleosides	60-70	involved in nucleotide metabolism	Human alphaherpesvirus 1	150-152
9675011-1	1998	Human 5"-nucleotidase (5"-NT, EC 3.1.3.5) is an enzyme that hydrolyzes nucleotides such as AMP or IMP (inosine 5"-monophosphate) into inorganic phosphate and the respective nucleoside.	Nucleosides	173-183	5'-nucleotidase ecto	Homo sapiens	6-21
9551690-12	1998	CONCLUSION: In this paper we show strong antitumor effects of the nucleoside analogs 2-CdA and dFdC on the human hepatoma cell line HepG2.	Nucleosides	66-76	cytidine deaminase	Homo sapiens	87-90
9660190-3	1998	The nikC gene was inactivated by inserting a kanamycin resistance cassette; the mutant did not produce the biologically active nikkomycins I, J, X, and Z, but accumulated the nucleoside moieties nikkomycins C(X) and C(Z).	Nucleosides	175-185	relaxosome accessory protein	Escherichia coli	4-8
9601049-7	1998	The main structural features of the UCCG and UGCG tetraloops are similar to those previously found in the UUCG and UACG tetraloops by means of NMR and vibrational spectroscopies, except those of the second nucleosides of the tetraloops (rC and rG, respectively) which adopt a 3"-endo/anti rather than a 2"-endo/anti conformation.	Nucleosides	206-217	UDP-glucose ceramide glucosyltransferase	Homo sapiens	45-49
9585525-10	1998	In addition, a well-ordered water molecule is found in the PNP active site when purine base or nucleoside is also present.	Nucleosides	95-105	purine nucleoside phosphorylase	Bos taurus	59-62
9480921-5	1998	So far, only a single nucleoside carrier-related cDNA (SPNT) has been isolated from liver cells (Che et al.	Nucleosides	22-32	solute carrier family 28 member 2	Rattus norvegicus	55-59
9480921-16	1998	These results suggest that liver parenchymal cells express at least two different isoforms of concentrative nucleoside carriers, the cNT1 and SPNT proteins, which show differential regulation and subcellular localization.	Nucleosides	108-118	solute carrier family 28 member 1	Rattus norvegicus	133-137
9480921-16	1998	These results suggest that liver parenchymal cells express at least two different isoforms of concentrative nucleoside carriers, the cNT1 and SPNT proteins, which show differential regulation and subcellular localization.	Nucleosides	108-118	solute carrier family 28 member 2	Rattus norvegicus	142-146
9795301-5	1998	In the other patients who had undergone various treatment regimens, the results obtained With the LiPA HIV-1 RT made in possible to retrospectively identify the different nucleoside analogs they had been treated with.	Nucleosides	171-181	lipase A, lysosomal acid type	Homo sapiens	98-102
9581584-3	1998	New antiretroviral strategies incorporating combination nucleoside analogues with a protease inhibitor lead to increased circulating CD4+ lymphocyte counts, decreased plasma levels of HIV, and decreased mortality from AIDS-defining opportunistic infections.	Nucleosides	56-66	CD4 molecule	Homo sapiens	133-136
9463485-2	1998	Its role in activation of pharmacologically used nucleoside analogs is not well understood, because of the low levels of dGK found in tissue extracts and its inactivation during purification.	Nucleosides	49-59	Diacyl glycerol kinase	Drosophila melanogaster	121-124
9463485-10	1998	The broad specificity of dGK described here may change our understanding of the mechanisms responsible for the efficacy and mitochondrial toxicity of several nucleoside analogs.	Nucleosides	158-168	Diacyl glycerol kinase	Drosophila melanogaster	25-28
9701498-3	1998	Inhibition of highly purified thymidylate synthase from mouse tumour Ehrlich carcinoma and leukemia L1210 cells by each of the nucleotide analogues, DHPFUMP, PMEFU and HEMFUMP, and of L5178Y mouse leukemia cell growth by the nucleoside (HEMFU) analogue, were studied.	Nucleosides	225-235	thymidylate synthase	Mus musculus	30-50
9598140-1	1998	Substrate/inhibitor specificities of nucleoside analogues with modified sugar moieties toward highly purified deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) from human leukemic spleen have been examined.	Nucleosides	37-47	deoxycytidine kinase	Homo sapiens	110-130
9338077-3	1998	First, the activity of ara-C depends on conversion to its lethal triphosphate derivative, ara-CTP, a process that is influenced by multiple factors, including nucleoside transport, phosphorylation, deamination, and levels of competing metabolites, particularly dCTP.	Nucleosides	159-169	solute carrier family 25 member 1	Homo sapiens	94-97
9598140-1	1998	Substrate/inhibitor specificities of nucleoside analogues with modified sugar moieties toward highly purified deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) from human leukemic spleen have been examined.	Nucleosides	37-47	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	132-135
9598140-1	1998	Substrate/inhibitor specificities of nucleoside analogues with modified sugar moieties toward highly purified deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) from human leukemic spleen have been examined.	Nucleosides	37-47	thymidine kinase 1	Homo sapiens	160-163
9598140-1	1998	Substrate/inhibitor specificities of nucleoside analogues with modified sugar moieties toward highly purified deoxycytidine kinase (dCK) and thymidine kinases (TK1 and TK2) from human leukemic spleen have been examined.	Nucleosides	37-47	thymidine kinase 2	Homo sapiens	168-171
9598144-0	1998	Activation of deoxycytidine kinase by various nucleoside analogues.	Nucleosides	46-56	deoxycytidine kinase	Homo sapiens	14-34
9598144-1	1998	The effect of different nucleoside analogues on deoxycytidine kinase (dCK) and thymidine kinase (TK) was compared in normal human lymphocytes and various leukemic cell lines.	Nucleosides	24-34	deoxycytidine kinase	Homo sapiens	48-68
9598144-1	1998	The effect of different nucleoside analogues on deoxycytidine kinase (dCK) and thymidine kinase (TK) was compared in normal human lymphocytes and various leukemic cell lines.	Nucleosides	24-34	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	70-73
9598144-8	1998	The possibility of interference of nucleoside analogues with the mechanisms of posttranslational modification of dCK was proposed.	Nucleosides	35-45	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	113-116
10353710-4	1998	Indeed, this biological activity appears to be the result of the co-expression of at least two isoforms of nucleoside carriers, CNT1 and CNT2 (also called SPNT).	Nucleosides	107-117	solute carrier family 28 member 1	Rattus norvegicus	128-132
10353710-4	1998	Indeed, this biological activity appears to be the result of the co-expression of at least two isoforms of nucleoside carriers, CNT1 and CNT2 (also called SPNT).	Nucleosides	107-117	solute carrier family 28 member 2	Rattus norvegicus	137-141
10353719-18	1998	Although some purine nucleosides (2"-deoxyadenosinedeoxyadeno-2"-deoxyadenosine, 7-deazaadenosine) were potent inhibitors of CNT1, they were poor permeants when uptake was measured directly by analysis of isotopic fluxes or indirectly by comparison of cytotoxicity ratios.	Nucleosides	21-32	solute carrier family 28 member 1	Rattus norvegicus	125-129
23899391-16	1998	This observation is supported by the data derived from in vitro DNA experiments but is different to our previously published data, which indicates the 2:1 (C-1:C-2) ratio in regioisomer formation in nucleotides or nucleosides.	Nucleosides	214-225	oogenesin 1	Mus musculus	156-159
10353710-4	1998	Indeed, this biological activity appears to be the result of the co-expression of at least two isoforms of nucleoside carriers, CNT1 and CNT2 (also called SPNT).	Nucleosides	107-117	solute carrier family 28 member 2	Rattus norvegicus	155-159
9514106-7	1998	The nucleoside analogue aciclovir (syn: acyclovir, Zovirax) is effective in inhibiting replication of VZV when given at a dosage higher than that required for treatment of HSV, and is currently the only available and approved treatment for varicella in the U.K. Intravenous aciclovir therapy for 5-10 days is effective for varicella in neonates and the immunocompromised, and for varicella pneumonia or other complications in adults and children, if begun early.	Nucleosides	4-14	synemin	Homo sapiens	35-38
23899391-16	1998	This observation is supported by the data derived from in vitro DNA experiments but is different to our previously published data, which indicates the 2:1 (C-1:C-2) ratio in regioisomer formation in nucleotides or nucleosides.	Nucleosides	214-225	complement component 2 (within H-2S)	Mus musculus	160-163
9342254-1	1997	The objective of this study was to identify prognostic factors for survival in patients with pretreatment CD4 < or =50 cells/mm3 treated with nucleoside analogs, and to develop and validate a mortality risk model based on these factors.	Nucleosides	145-155	CD4 molecule	Homo sapiens	106-109
9595413-8	1998	Injection of ET-1 did not result in further RH reduction in GLIB-pretreated dogs (group II) but significantly increased nucleoside release.	Nucleosides	120-130	endothelin 1	Canis lupus familiaris	13-17
9435697-3	1997	Functional expression in Xenopus laevis oocytes identified hSPNT1 as a Na(+)-dependent nucleoside transporter that selectively transports purine nucleosides but also transports uridine.	Nucleosides	145-156	solute carrier family 28 member 2	Homo sapiens	59-65
9371251-3	1997	Among the nucleoside analogues the Ara-C derivatives 3 and 6 and the Ara-A derivative 7 proved the most cytostatic (IC50 < 0.32 microgram/mL) resulting from 25- to > 144-fold more active (Ara-A derivatives) or at least as equally active (Ara-C derivatives) as compared to the parent nucleosides.	Nucleosides	10-20	ATP binding cassette subfamily C member 6	Homo sapiens	35-38
9371251-3	1997	Among the nucleoside analogues the Ara-C derivatives 3 and 6 and the Ara-A derivative 7 proved the most cytostatic (IC50 < 0.32 microgram/mL) resulting from 25- to > 144-fold more active (Ara-A derivatives) or at least as equally active (Ara-C derivatives) as compared to the parent nucleosides.	Nucleosides	10-20	ATP binding cassette subfamily C member 6	Homo sapiens	69-72
9371251-3	1997	Among the nucleoside analogues the Ara-C derivatives 3 and 6 and the Ara-A derivative 7 proved the most cytostatic (IC50 < 0.32 microgram/mL) resulting from 25- to > 144-fold more active (Ara-A derivatives) or at least as equally active (Ara-C derivatives) as compared to the parent nucleosides.	Nucleosides	10-20	ATP binding cassette subfamily C member 6	Homo sapiens	69-72
9371251-3	1997	Among the nucleoside analogues the Ara-C derivatives 3 and 6 and the Ara-A derivative 7 proved the most cytostatic (IC50 < 0.32 microgram/mL) resulting from 25- to > 144-fold more active (Ara-A derivatives) or at least as equally active (Ara-C derivatives) as compared to the parent nucleosides.	Nucleosides	10-20	ATP binding cassette subfamily C member 6	Homo sapiens	69-72
9371251-3	1997	Among the nucleoside analogues the Ara-C derivatives 3 and 6 and the Ara-A derivative 7 proved the most cytostatic (IC50 < 0.32 microgram/mL) resulting from 25- to > 144-fold more active (Ara-A derivatives) or at least as equally active (Ara-C derivatives) as compared to the parent nucleosides.	Nucleosides	289-300	ATP binding cassette subfamily C member 6	Homo sapiens	35-38
9371251-3	1997	Among the nucleoside analogues the Ara-C derivatives 3 and 6 and the Ara-A derivative 7 proved the most cytostatic (IC50 < 0.32 microgram/mL) resulting from 25- to > 144-fold more active (Ara-A derivatives) or at least as equally active (Ara-C derivatives) as compared to the parent nucleosides.	Nucleosides	289-300	ATP binding cassette subfamily C member 6	Homo sapiens	69-72
9371251-3	1997	Among the nucleoside analogues the Ara-C derivatives 3 and 6 and the Ara-A derivative 7 proved the most cytostatic (IC50 < 0.32 microgram/mL) resulting from 25- to > 144-fold more active (Ara-A derivatives) or at least as equally active (Ara-C derivatives) as compared to the parent nucleosides.	Nucleosides	289-300	ATP binding cassette subfamily C member 6	Homo sapiens	69-72
9371251-3	1997	Among the nucleoside analogues the Ara-C derivatives 3 and 6 and the Ara-A derivative 7 proved the most cytostatic (IC50 < 0.32 microgram/mL) resulting from 25- to > 144-fold more active (Ara-A derivatives) or at least as equally active (Ara-C derivatives) as compared to the parent nucleosides.	Nucleosides	289-300	ATP binding cassette subfamily C member 6	Homo sapiens	69-72
9354442-0	1997	Potent antitumor activity of a novel nucleoside analogue, BCH-4556 (beta-L-dioxolane-cytidine), in human renal cell carcinoma xenograft tumor models.	Nucleosides	37-47	chimerin 2	Homo sapiens	58-61
9354442-1	1997	Beta-L-Dioxolane-cytidine (BCH-4556) is a novel anticancer nucleoside analogue with a stereochemically unnatural beta-L configuration.	Nucleosides	59-69	chimerin 2	Homo sapiens	27-30
9354442-13	1997	The observed antitumor activity of BCH-4556 in several RCC human solid tumor xenografts, including the lethal RXF-393 model, warrants further investigation of this novel nucleoside analogue in clinical trials of RCC.	Nucleosides	170-180	chimerin 2	Homo sapiens	35-38
9342341-7	1997	Reconstitution of a deoxycytidine kinase-deficient cell line with the wild-type nuclear or the mutant cytosolic enzymes both restored sensitivity toward anticancer nucleoside analogs.	Nucleosides	164-174	deoxycytidine kinase	Homo sapiens	20-40
9808420-7	1998	These observations suggest that the expression of c-Myc might be related to an intracellular sensing system for the quantitative balance of nucleosides or nucleotides.	Nucleosides	140-151	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	50-55
9353301-3	1997	When expressed in Xenopus oocytes, hENT1 mediated es-type transport activity and was inhibited by coronary vasoactive drugs (dipyridamole and dilazep) that may compete with nucleosides and NBMPR for binding to the substrate binding site.	Nucleosides	173-184	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	35-40
9287227-0	1997	A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less.	Nucleosides	26-36	CD4 molecule	Homo sapiens	121-124
9330759-9	1997	The rVVs proved to be a suitable tool for analysis of UL97-dependent phosphorylation of nucleoside analogs and also allowed to quantitatively study the influence of UL97 mutations on drug phosphorylation.	Nucleosides	88-98	tegument serine/threonine protein kinase	Human betaherpesvirus 5	54-58
11322272-7	1997	With the introduction of the nucleoside analogues, infectious cell counts and plasma virus dropped another log unit to a nadir at 8 weeks, while CD4 T lymphocyte counts continued to rise slowly.	Nucleosides	29-39	CD4 molecule	Homo sapiens	145-148
9218488-6	1997	Interaction of both proteins with the L2a element was studied using the missing nucleoside approach, DNase I footprinting, and electrophoretic mobility shift assays with wild type and mutant L2a elements.	Nucleosides	80-90	matrix associated region 1	Mus musculus	38-41
9490627-0	1997	[New nucleoside conjugates with phospholipids: synthesis of anti-HIV activity of rac-1-hexadecyl-2-acyl-sn-glycero-3-phosphonucleosides].	Nucleosides	5-15	Rac family small GTPase 1	Homo sapiens	81-86
9261067-6	1997	RESULTS: The three-dimensional crystal structures of free and nucleoside complexed FHIT have been determined from multiwavelength anomalous diffraction (MAD) data, and they represent some of the first successful structures to be measured with undulator radiation at the Advanced Photon Source.	Nucleosides	62-72	fragile histidine triad diadenosine triphosphatase	Homo sapiens	83-87
9646223-4	1997	The majority of experiments referred to in this paper were performed employing a conjugate of lactosaminated human albumin with adenine arabinoside monophosphate (ara-AMP), a phosphorylated nucleoside analogue active against hepatitis B virus.	Nucleosides	190-200	adenine phosphoribosyltransferase	Homo sapiens	167-170
9453839-6	1997	A statistically significant increase in CD4 counts was only observed in the group treated with the association of 2 nucleoside analogues and 1 proteinase inhibitor.	Nucleosides	116-126	CD4 molecule	Homo sapiens	40-43
9144579-1	1997	The expression of sodium-dependent purine nucleoside transport (SPNT) mRNA has been studied in physiological situations in which Na+-dependent nucleoside uptake in plasma membrane vesicles from rat liver was induced.	Nucleosides	42-52	solute carrier family 28 member 2	Rattus norvegicus	64-68
21590098-3	1997	In contrast, other new nucleoside analogues such as the purine antimetabolite fludarabine lead to a significant alteration of the CD4/CD8 lymphocyte ratio associated with an increased risk for opportunistic infections.	Nucleosides	23-33	CD4 molecule	Homo sapiens	130-133
21590098-3	1997	In contrast, other new nucleoside analogues such as the purine antimetabolite fludarabine lead to a significant alteration of the CD4/CD8 lymphocyte ratio associated with an increased risk for opportunistic infections.	Nucleosides	23-33	CD8a molecule	Homo sapiens	134-137
9144579-5	1997	These results suggest that the induction of the sodium-dependent nucleoside transport expressed in liver parenchymal cells involves regulation of SPNT gene expression.	Nucleosides	65-75	solute carrier family 28 member 2	Rattus norvegicus	146-150
11322281-0	1997	Viraemia and p24 antigenaemia are independent risk factors for the emergency of a zidovudine-resistant genotype in nucleoside analogue-treated HIV-1 infection.	Nucleosides	115-125	transmembrane p24 trafficking protein 2	Homo sapiens	13-16
9178835-2	1997	Recently, the high activity of nucleoside analogs as fludarabine (FAMP), 2-chlorodeoxyadenosine (2-CDA) and 2-deoxycoformycin (DCF) in low-grade NHLs has caused a new reawakening interest in CLL concerning new treatment strategies, the biology and prognostic factors of this disease.	Nucleosides	31-41	cytidine deaminase	Homo sapiens	99-102
9079672-5	1997	The recombinant TK2 was shown to phosphorylate the anti-cancer nucleoside analog 2",2"-difluorodeoxycytidine.	Nucleosides	63-73	thymidine kinase 2	Homo sapiens	16-19
9209454-4	1997	Using this vector, almost all the MDR1-transduced cells showed hypersensitivity to a nucleoside analog, ganciclovir.	Nucleosides	85-95	ATP binding cassette subfamily B member 1	Homo sapiens	34-38
9238982-3	1997	And it is now clear that triple combinations of drugs (typically two nucleoside analogues and one protease inhibitor) are producing excellent reductions in viral load with concomitant elevations in CD4+ counts.	Nucleosides	69-79	CD4 molecule	Homo sapiens	198-201
9178291-6	1997	However, oral administration of nucleosides and nucleotides in experimental colitis resulted in a worsening of colitic conditions and increased interleukin-8 and tumor necrosis factor-alpha concentrations in inflamed colonic portions, indicating the pro-inflammatory activities of nucleosides and nucleotides.	Nucleosides	32-43	chemokine (C-X-C motif) ligand 15	Mus musculus	144-189
9178291-6	1997	However, oral administration of nucleosides and nucleotides in experimental colitis resulted in a worsening of colitic conditions and increased interleukin-8 and tumor necrosis factor-alpha concentrations in inflamed colonic portions, indicating the pro-inflammatory activities of nucleosides and nucleotides.	Nucleosides	281-292	chemokine (C-X-C motif) ligand 15	Mus musculus	144-189
9016611-2	1997	Previous work has shown that the DNA sequence recognized by Reb1p contains an adenosine residue that is unusually reactive toward chemical modification by dimethylsulfate and that methylation of this nucleoside increases the binding affinity of the Reb1p protein for its target.	Nucleosides	200-210	DNA-binding protein REB1	Saccharomyces cerevisiae S288C	60-65
9113412-1	1997	CD73 (ecto-5"-nucleotidase), a glycosyl phosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surface of human T and B lymphocytes, catalyzes the conversion of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates to the corresponding nucleosides.	Nucleosides	269-280	5'-nucleotidase ecto	Homo sapiens	0-4
9113412-1	1997	CD73 (ecto-5"-nucleotidase), a glycosyl phosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surface of human T and B lymphocytes, catalyzes the conversion of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates to the corresponding nucleosides.	Nucleosides	269-280	5'-nucleotidase ecto	Homo sapiens	6-26
9016611-2	1997	Previous work has shown that the DNA sequence recognized by Reb1p contains an adenosine residue that is unusually reactive toward chemical modification by dimethylsulfate and that methylation of this nucleoside increases the binding affinity of the Reb1p protein for its target.	Nucleosides	200-210	DNA-binding protein REB1	Saccharomyces cerevisiae S288C	249-254
8967974-6	1996	Recombinant rCNT1 mediated efflux of [3H]uridine from preloaded oocytes, demonstrating a capacity for bidirectional transport of nucleoside permeants.	Nucleosides	129-139	solute carrier family 28 member 1	Rattus norvegicus	12-17
9361795-12	1997	2.5"-Nucleotidase (5"-NT) is an enzyme that hydrolyzes nucleotides such as AMP or IMP into inorganic phosphate and the respective nucleoside.	Nucleosides	130-140	5'-nucleotidase ecto	Homo sapiens	2-17
9421132-3	1997	In the nervous system, purines have important neuromodulatory actions, acting at pre- and postsynaptic sites, and consequently, ecto-apyrase may play an indirect role in the modulation of nucleotide- and nucleoside-mediated processes.	Nucleosides	204-214	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	128-140
8978848-1	1996	As a part of our efforts to design prodrugs for antiviral nucleosides, 9-(beta-D-arabinofuranosyl)-6-azidopurine (6-AAP) was synthesized as a prodrug for ara-A that utilizes the azide reduction biotransformation pathway.	Nucleosides	58-69	active avoidance performance	Mus musculus	116-119
9478205-5	1997	The structure of the anticodon loop is distinctly different from that seen for other tRNAs exemplified by tRNA(Phe), suggesting that the full complement of modified nucleosides present in tRNA(Lys,3) should significantly change the structure compared to the unmodified tRNA anticodon loop.	Nucleosides	165-176	mitochondrially encoded tRNA glycine	Homo sapiens	188-198
9478205-6	1997	The conformation of the loop has important implications for the role of nucleoside modification in codon-anticodon recognition and for utilization of tRNA(Lys,3) by HIV-1 as the natural reverse transcriptase primer.	Nucleosides	72-82	mitochondrially encoded tRNA glycine	Homo sapiens	150-160
8970669-8	1996	Data from surrogate marker studies suggest that even greater reductions in viral load and increments in CD4+ count can be seen using triple therapy, either with two nucleosides and a non-nucleoside reverse transcriptase inhibitor, or two nucleoside analogues and a protease inhibitor.	Nucleosides	165-176	CD4 molecule	Homo sapiens	104-107
8970669-8	1996	Data from surrogate marker studies suggest that even greater reductions in viral load and increments in CD4+ count can be seen using triple therapy, either with two nucleosides and a non-nucleoside reverse transcriptase inhibitor, or two nucleoside analogues and a protease inhibitor.	Nucleosides	165-175	CD4 molecule	Homo sapiens	104-107
9031099-14	1996	Finally, whereas CLB and nucleoside analogs may produce cell death in CLL by a P53 dependent pathway other agents, such as dexamethasone or vincristine, may act through P53-independent pathways.	Nucleosides	25-35	tumor protein p53	Homo sapiens	79-82
8939183-4	1996	A unique feature of ICln is the distinct sensitivity of these channels for nucleotides and nucleoside analogues added to the extracellular fluid.	Nucleosides	91-101	chloride nucleotide-sensitive channel 1A pseudogene 1	Homo sapiens	20-24
8813038-0	1996	A trial comparing nucleoside monotherapy with combination therapy in HIV-infected adults with CD4 cell counts from 200 to 500 per cubic millimeter.	Nucleosides	18-28	CD4 molecule	Homo sapiens	94-97
8911867-1	1996	The objective of the present study was to investigate the effect of the nucleoside analogue treatment on serum viraemia, CD4+ cell count and disease progression in patients with and without syncytium-inducing (SI) HIV-1 variants.	Nucleosides	72-82	CD4 molecule	Homo sapiens	121-124
8713072-3	1996	The production of recombinant cNT1rat was examined by immunoblotting using an epitope-tagged construct and by analysis of inward fluxes of 3H-labelled nucleosides.	Nucleosides	151-162	solute carrier family 28 member 1	Rattus norvegicus	30-34
8894103-5	1996	In the case of the nucleoside-containing amino acids, a potential multisubstrate adduct inhibitor of catechol O-methyltransferase was synthesized via this route.	Nucleosides	19-29	catechol-O-methyltransferase	Homo sapiens	101-129
8713072-6	1996	A variety of anti-viral and anti-cancer nucleoside drugs inhibited cNT1rat-mediated uptake of uridine by transfected COS-1 cells although to different extents (Floxidine > Idoxuridine > Zidovudine > Zalcitabine > Cytarabine > Gemcitabine), suggesting that the concentrative pyrimidine-selective nucleoside transporters, of which cNT1rat is a representative, may play a role in cellular uptake of these drugs.	Nucleosides	40-50	solute carrier family 28 member 1	Rattus norvegicus	67-71
8645738-1	1996	Cytosolic 5"-nucleotidase, acting preferentially on IMP, GMP and their deoxyderivatives, can also behave as a phosphotransferase, operating a transfer of phosphate from a nucleoside monophosphate donor to a nucleoside acceptor which, besides a natural nucleoside, can be also an analog.	Nucleosides	171-181	5'-nucleotidase ecto	Homo sapiens	10-25
8709116-1	1996	The synthesis and the antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported.	Nucleosides	58-68	complement C3	Homo sapiens	46-49
8853292-16	1996	Two genes have been identified which encode sodium-dependent adenosine transport proteins, SNST1 from the sodium/glucose cotransporter (SGLT1) gene family and the rat intestinal N2 transporter (cNT1) from a novel gene family including a bacterial nucleoside carrier (NupC).	Nucleosides	247-257	solute carrier family 5 member 1	Rattus norvegicus	136-141
8853292-16	1996	Two genes have been identified which encode sodium-dependent adenosine transport proteins, SNST1 from the sodium/glucose cotransporter (SGLT1) gene family and the rat intestinal N2 transporter (cNT1) from a novel gene family including a bacterial nucleoside carrier (NupC).	Nucleosides	247-257	solute carrier family 28 member 1	Rattus norvegicus	194-198
8645738-1	1996	Cytosolic 5"-nucleotidase, acting preferentially on IMP, GMP and their deoxyderivatives, can also behave as a phosphotransferase, operating a transfer of phosphate from a nucleoside monophosphate donor to a nucleoside acceptor which, besides a natural nucleoside, can be also an analog.	Nucleosides	207-217	5'-nucleotidase ecto	Homo sapiens	10-25
8818838-4	1996	Results from 14 randomized controlled trials of nucleoside analogues are used to compare the comparative changes of CD4 counts with the differential rates of progression to AIDS and differences in survival.	Nucleosides	48-58	CD4 molecule	Homo sapiens	116-119
8625309-0	1996	Retroviral transfer of deoxycytidine kinase into tumor cell lines enhances nucleoside toxicity.	Nucleosides	75-85	deoxycytidine kinase	Homo sapiens	23-43
8625309-1	1996	Deoxycytidine kinase (dCK) phosphorylates a number of nucleoside analogues that are useful in the treatment of various malignancies.	Nucleosides	54-64	deoxycytidine kinase	Homo sapiens	0-20
8625309-1	1996	Deoxycytidine kinase (dCK) phosphorylates a number of nucleoside analogues that are useful in the treatment of various malignancies.	Nucleosides	54-64	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
8621662-8	1996	MTP may function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.	Nucleosides	37-48	microsomal triglyceride transfer protein, gene 1 S homeolog	Xenopus laevis	0-3
8656052-6	1996	When extracellular concentrations of endogenously formed adenosine were enhanced by the nucleoside uptake inhibitor dipyridamole, up-regulation of beta2 integrins, and shedding of L-selectin was again inhibited.	Nucleosides	88-98	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	147-152
8621662-8	1996	MTP may function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.	Nucleosides	37-47	microsomal triglyceride transfer protein, gene 1 S homeolog	Xenopus laevis	0-3
8648611-4	1996	For all the foregoing nucleosides in the fixed syn conformation about the glycosyl bond, 1H NMR spectroscopy further demonstrated that the pentose rings exist predominantly in the conformation N (3"-endo).	Nucleosides	22-33	synemin	Homo sapiens	47-50
8626289-2	1996	In particular, the transcription of genes needed for utilization of nucleosides in Escherichia coli is regulated by a repressor protein, CytR, in concert with the cyclic AMP (cAMP) activated form of cAMP receptor protein (CRP).	Nucleosides	68-79	catabolite gene activator protein	Escherichia coli	199-220
8618470-4	1996	Nucleoside analogs such as chlorodeoxyadenosine (2-CdA) or fludarabine have shown single-agent efficacy and may be synergistic with ara-C.	Nucleosides	0-10	cytidine deaminase	Homo sapiens	51-54
8626289-2	1996	In particular, the transcription of genes needed for utilization of nucleosides in Escherichia coli is regulated by a repressor protein, CytR, in concert with the cyclic AMP (cAMP) activated form of cAMP receptor protein (CRP).	Nucleosides	68-79	catabolite gene activator protein	Escherichia coli	222-225
8923453-2	1996	A strong negative regulatory element has been shown by the missing nucleoside technique to be a CACGTG site (E-box) in the proximal part of the PN-1 promoter.	Nucleosides	67-77	serpin family E member 2	Homo sapiens	144-148
8552101-2	1996	Analysis of the interactions between purified recombinant AMT1 protein and the AMT1 promoter metal regulatory element was carried out by a combination of missing-nucleoside analysis, ethylation interference, site-directed mutagenesis, and quantitative in vitro DNA binding studies.	Nucleosides	162-172	ammonium permease MEP1	Saccharomyces cerevisiae S288C	58-62
8552101-2	1996	Analysis of the interactions between purified recombinant AMT1 protein and the AMT1 promoter metal regulatory element was carried out by a combination of missing-nucleoside analysis, ethylation interference, site-directed mutagenesis, and quantitative in vitro DNA binding studies.	Nucleosides	162-172	ammonium permease MEP1	Saccharomyces cerevisiae S288C	79-83
8790720-6	1996	Alternative routes for phosphorylation of nucleoside analogs are also reviewed, such as the phosphotransfer capacity of 5"-nucleotidase and protein kinases.	Nucleosides	42-52	5'-nucleotidase ecto	Homo sapiens	120-135
8576054-11	1996	As bacterial numbers reached densities between 8.0 x 10(5) and 2.0 x 10(6) cells per mm2, there was a small increase in the incorporation of radiolabeled nucleosides per cell.	Nucleosides	154-165	PNMA family member 2	Homo sapiens	85-88
8576054-12	1996	At 2.5 x 10(6) to 4.0 x 10(6) cells per mm2 of enamel surface, there was a marked increase in the incorporation of radiolabeled nucleosides per cell which appeared to be cell-density dependent.	Nucleosides	128-139	PNMA family member 2	Homo sapiens	40-43
19927594-8	1996	Finally, the presence of a suitable substrate for the phosphotransferase activity of cytosolic 5"-nucleotidase caused a stimulation of the rate of formation of the nucleoside.	Nucleosides	164-174	5'-nucleotidase ecto	Homo sapiens	95-110
8999463-1	1996	2-chlorodeoxyadenosine (2-CdA) is a simple nucleoside derived from deoxyadenosine by substituting chloride for hydrogen in 2" position of the purine ring, which renders it resistant to degradation by adenosine deaminase.	Nucleosides	43-53	cytidine deaminase	Homo sapiens	26-29
8999463-1	1996	2-chlorodeoxyadenosine (2-CdA) is a simple nucleoside derived from deoxyadenosine by substituting chloride for hydrogen in 2" position of the purine ring, which renders it resistant to degradation by adenosine deaminase.	Nucleosides	43-53	adenosine deaminase	Homo sapiens	200-219
7593232-1	1995	Differentiation of the megakaryocytic leukemia cells, CMK, was induced by long-term (12 day) treatment with the combination of IL-3 and the nucleoside analogue ribavirin (RV), which reduces cellular GTP levels.	Nucleosides	140-150	cytidine/uridine monophosphate kinase 1	Homo sapiens	54-57
7791126-9	1995	Regulation of BMDM phi IL-6 by carbocyclic nucleoside analogues in response to LPS appears to be both concentration and time dependent, because IL-6 mRNA and secreted protein levels were inhibited at only high drug concentrations (100 microM) and effective only at longer exposure times (+4 hr of incubation) to LPS.	Nucleosides	43-53	interleukin 6	Mus musculus	23-27
7503760-0	1995	Production of adenosine and nucleoside analogs by the exchange reaction catalyzed by rat liver adenosine kinase.	Nucleosides	28-38	adenosine kinase	Rattus norvegicus	95-111
7585520-0	1995	Characterization of the receptor protein tyrosine phosphatase gene product PTP gamma: binding and activation by triphosphorylated nucleosides.	Nucleosides	130-141	protein tyrosine phosphatase receptor type U	Homo sapiens	75-78
7565681-0	1995	A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice.	Nucleosides	79-89	involved in nucleotide metabolism	Human alphaherpesvirus 1	33-49
7565681-1	1995	Dividing eukaryotic cells expressing the herpes simplex virus type 1 thymidine kinase (TK) gene are sensitive to the cytotoxic effect of nucleoside analogs such as acyclovir or ganciclovir (GCV).	Nucleosides	137-147	involved in nucleotide metabolism	Human alphaherpesvirus 1	69-85
7565681-1	1995	Dividing eukaryotic cells expressing the herpes simplex virus type 1 thymidine kinase (TK) gene are sensitive to the cytotoxic effect of nucleoside analogs such as acyclovir or ganciclovir (GCV).	Nucleosides	137-147	involved in nucleotide metabolism	Human alphaherpesvirus 1	87-89
7627962-9	1995	A comparable antitumor effect was also found when a related nucleoside analogue, 5-propynyloxy-2"-deoxyuridine, was used with FUra+IFN, and it also showed modulating activity when used with only FUra.	Nucleosides	60-70	interferon alpha 1	Homo sapiens	131-134
7629106-2	1995	Here we report the existence of a biochemical mechanism for the induction of neuronal death by an endogenous nucleoside in the presence of NGF.	Nucleosides	109-119	nerve growth factor	Homo sapiens	139-142
7503760-6	1995	Administration of therapeutic anticancer and antiviral nucleosides that can serve as substrates for the exchange reaction catalyzed by adenosine kinase might, thus, result in a net production of Ado, a potent autacoid with physiological effects in numerous tissues.	Nucleosides	55-66	adenosine kinase	Rattus norvegicus	135-151
8748457-7	1995	In addition, the mutant cells excrete a large amount of deoxycytidine into culture medium, consistent with a failure of salvage of the nucleoside in the absence of an appropriate kinase, i.e., deoxycytidine kinase.	Nucleosides	135-145	deoxycytidine kinase	Mus musculus	193-213
8555407-2	1995	The 1H and 13C NMR features of the two modified nucleosides obtained in DMSO-d6 are indicative of a similar formamidopyrimidine structure for the base residue (the ring-opened form of a C-8 hydroxylated purine).	Nucleosides	48-59	homeobox C8	Homo sapiens	186-189
7562929-3	1995	Displacement of the 4-chloro group of 3 with OH, NH2, NHOH, SH, and SeH nucleophiles furnished the corresponding nucleosides 6-8, 12, and 14, respectively.	Nucleosides	113-124	epoxide hydrolase 2	Homo sapiens	68-71
7759895-9	1995	Treatment with 2"-beta-fluoro-2",3"-dideoxyadenosine, a nucleoside analogue, significantly reduced CD4+ T cell depletion (CD4 = 13 +/- 1; n = 59; p < 0.001) and the frequency of virus isolation (70%; p = 0.015) in the hu-HIV/PBL-SCID model.	Nucleosides	56-66	CD4 antigen	Mus musculus	99-102
7759895-9	1995	Treatment with 2"-beta-fluoro-2",3"-dideoxyadenosine, a nucleoside analogue, significantly reduced CD4+ T cell depletion (CD4 = 13 +/- 1; n = 59; p < 0.001) and the frequency of virus isolation (70%; p = 0.015) in the hu-HIV/PBL-SCID model.	Nucleosides	56-66	CD4 antigen	Mus musculus	122-125
7749792-6	1995	The identification and treatment of peripheral neuropathies associated with use of the nucleoside drugs zalcitabine (ddC), didanosine (ddI), and stavudine (d4T) are reviewed.	Nucleosides	87-97	dopa decarboxylase	Homo sapiens	117-120
7791126-9	1995	Regulation of BMDM phi IL-6 by carbocyclic nucleoside analogues in response to LPS appears to be both concentration and time dependent, because IL-6 mRNA and secreted protein levels were inhibited at only high drug concentrations (100 microM) and effective only at longer exposure times (+4 hr of incubation) to LPS.	Nucleosides	43-53	interleukin 6	Mus musculus	144-148
7542140-9	1995	CONCLUSIONS: The non-nucleoside inhibitor-binding pocket has a flexible structure whose mobility may be required for effective polymerization, and may be part of a hinge that permits relative movements of two subdomains of the p66 subunit denoted the "palm" and "thumb".	Nucleosides	21-31	DNA polymerase delta 3, accessory subunit	Homo sapiens	227-230
7706474-1	1995	Deoxycytidine kinase (dCK) phosphorylates 2"-deoxycytidine, as well as the purine deoxyribonucleosides and a number of nucleoside analogues that are important in the chemotherapy of leukemias.	Nucleosides	91-101	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
7540935-3	1995	Comparison with the structures of four different RT and non-nucleoside inhibitor complexes reveals that only minor domain rearrangements occur, but there is a significant repositioning of a three-stranded beta-sheet in the p66 subunit (containing the catalytic aspartic acid residues 110, 185 and 186) with respect to the rest of the polymerase site.	Nucleosides	60-70	DNA polymerase delta 3, accessory subunit	Homo sapiens	223-226
7837231-3	1995	The introduction of a vinyl group at C-6 of uridine or an ethynyl group at C-8 of adenosine resulted in nucleoside derivatives showing cytostatic activity against several murine and/or human tumor cell lines.	Nucleosides	104-114	complement component 6	Mus musculus	37-40
7540494-1	1995	The prolonged use of anti-viral nucleosides (ZDV, ddI, ddC) in HIV-infected patients has given rise to the isolation of viral variants that display resistance against these compounds.	Nucleosides	32-43	dopa decarboxylase	Homo sapiens	55-58
7633946-4	1995	The rationale for this approach was that ACV and GCV are nucleoside analogs specifically converted by HSV1-TK to a toxic form capable of inhibiting DNA synthesis or disrupting cellular DNA replication.	Nucleosides	57-67	involved in nucleotide metabolism	Human alphaherpesvirus 1	107-109
7837231-3	1995	The introduction of a vinyl group at C-6 of uridine or an ethynyl group at C-8 of adenosine resulted in nucleoside derivatives showing cytostatic activity against several murine and/or human tumor cell lines.	Nucleosides	104-114	cell division cycle associated 3	Mus musculus	75-78
7542321-0	1995	Comparison of the inhibition of type A and type B S-adenosylhomocysteine hydrolase: effects of cofactor content on inhibition behavior and nucleoside binding.	Nucleosides	139-149	adenosylhomocysteinase	Bos taurus	50-82
8724854-2	1995	IFN-alpha treatment influenced the metabolism of exogenously supplied nucleobases and nucleosides in a manner expected to contribute to synergistic activity.	Nucleosides	86-97	interferon alpha 1	Homo sapiens	0-9
8724854-5	1995	The effects of IFN-alpha on nucleobase/nucleoside metabolism could contribute to synergistic antiviral activity by reducing the accumulation of thymidine/thymine metabolites and decreasing the guanine taken into cells.	Nucleosides	39-49	interferon alpha 1	Homo sapiens	15-24
8866660-1	1995	Adaptive changes occurring in C1300 murine neuroblastoma cell lines developed for resistance to nucleoside analogue inhibitors of S-adenosyl-L-homocysteine hydrolase (AdoHcyase, EC 3.3.1.1) were investigated.	Nucleosides	96-106	S-adenosylhomocysteine hydrolase	Mus musculus	167-176
18472761-2	1995	Highlights on the discovery, of the drug and the development of it"s second generation derivatives are presented, as well as the ways that cis -DDP reacts with biomolecules as DNA and proteins and their models e.g. nucleosides, nucleotides.	Nucleosides	215-226	translocase of inner mitochondrial membrane 8A	Homo sapiens	144-147
8643387-4	1995	Of particular interest is the increasingly documented relationship between the presence of modified nucleosides in tRNAs, and the site and affinity of Mg2+ binding to RNA and its effect on function.	Nucleosides	100-111	mucin 7, secreted	Homo sapiens	151-154
7845029-1	1995	We have previously reported that the chain-terminating nucleoside analogue 2",3"-dideoxyadenosine (ddA) is specifically cytotoxic for TdT-positive cells in the co-presence of the adenosine deaminase (ADA) inhibitor coformycin (CF).	Nucleosides	55-65	DNA nucleotidylexotransferase	Homo sapiens	134-137
7845029-1	1995	We have previously reported that the chain-terminating nucleoside analogue 2",3"-dideoxyadenosine (ddA) is specifically cytotoxic for TdT-positive cells in the co-presence of the adenosine deaminase (ADA) inhibitor coformycin (CF).	Nucleosides	55-65	adenosine deaminase	Homo sapiens	179-198
7845029-1	1995	We have previously reported that the chain-terminating nucleoside analogue 2",3"-dideoxyadenosine (ddA) is specifically cytotoxic for TdT-positive cells in the co-presence of the adenosine deaminase (ADA) inhibitor coformycin (CF).	Nucleosides	55-65	adenosine deaminase	Homo sapiens	200-203
7695256-1	1994	Inhibition constants were determined for 16 nucleoside analog triphosphates against human DNA polymerases alpha, beta, gamma, and epsilon, and 7 nucleoside analogs were examined as inhibitors of mitochondrial DNA synthesis in human Molt-4 cells in culture.	Nucleosides	44-54	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	90-144
7816637-5	1994	This represents the first experimental evidence for a nucleic acid structure containing two sequential nucleosides in the syn conformation.	Nucleosides	103-114	synemin	Homo sapiens	122-125
7494863-7	1995	Finally, alternative pathways for nucleoside analogue phosphorylation are surveyed, such as the phosphotransfer capacity of 5"-nucleotidase.	Nucleosides	34-44	5'-nucleotidase ecto	Homo sapiens	124-139
7695256-1	1994	Inhibition constants were determined for 16 nucleoside analog triphosphates against human DNA polymerases alpha, beta, gamma, and epsilon, and 7 nucleoside analogs were examined as inhibitors of mitochondrial DNA synthesis in human Molt-4 cells in culture.	Nucleosides	145-155	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	90-144
8002395-0	1994	Antitumor activity of SPM VIII, a derivative of the nucleoside antibiotic spicamycin, against human tumor xenografts.	Nucleosides	52-62	cytochrome c oxidase subunit 8A	Homo sapiens	26-30
7986250-1	1994	Gemcitabine (2",2"-difluorodeoxycytidine monohydrochloride, LY188011 hydrochloride, CAS 122111-03-9) is a nucleoside analog with a broad spectrum of antitumor activity in murine models and is currently undergoing clinical evaluation.	Nucleosides	106-116	breast cancer anti-estrogen resistance 1	Mus musculus	84-87
8031847-5	1994	Adenosine treatment to CCl4-poisoned rats was able to counteract the effect of the hepatotoxin on the redox equilibrium; hence, it could be linked to the beneficial action of the nucleoside in the maintenance of mitochondrial function.	Nucleosides	179-189	C-C motif chemokine ligand 4	Rattus norvegicus	23-27
8068016-5	1994	In conclusion, our data demonstrate that both TK and TMPK activities encoded by HSV-1 share a common active site which is very tolerant in accepting modified nucleosides, but cannot readily accommodate modified nucleoside monophosphates.	Nucleosides	158-169	involved in nucleotide metabolism	Human alphaherpesvirus 1	46-48
8025106-8	1994	As on the wild-type enzyme, the conformation of dTdA on the D21E mutant is highly extended, with high-anti C-2" endo conformations for the individual nucleosides.	Nucleosides	150-161	complement C2	Homo sapiens	107-110
8027026-5	1994	Functionally, cNT1 exhibited the transport characteristics of the nucleoside transport system cit (selective for pyrimidine nucleosides and adenosine) and accepted both 3"-azido-3"-deoxythymidine (AZT) and 2",3"-dideoxycytidine (ddC) as permeants (Km = 0.49 and 0.51 mM, respectively).	Nucleosides	66-76	solute carrier family 28 member 1	Homo sapiens	14-18
8021297-3	1994	We developed an alternative induction protocol for the megakaryocytic leukemic cell line CMK, which involved incubation of the cells with IL-3 and the nucleoside analog, ribavirin, for 1-2 weeks.	Nucleosides	151-161	C-X-C motif chemokine ligand 9	Homo sapiens	89-92
7913513-1	1994	The nucleoside analog 2-chlorodeoxyadenosine (2-CdA) has recently emerged as a most promising treatment for hair-cell leukemia (HCL).	Nucleosides	4-14	cytidine deaminase	Homo sapiens	48-51
8086132-3	1994	RESULTS: The concentrations of compound required to inhibit viral p24 antigen production by 50% [median inhibitory concentration (IC50)] for nucleosides were as follows: zidovudine, 0.001-->5 microM; ddC, < 0.01-0.23 microM; ddI, 0.2-->25 microM).	Nucleosides	141-152	transmembrane p24 trafficking protein 2	Homo sapiens	66-69
8027512-10	1994	In addition, various nucleoside analogs, including acyclovir and trifluridine as well as adenosine, guanosine and dibutyryl cyclic AMP, also potentiated the toxicity of ricin.	Nucleosides	21-31	ricin	Ricinus communis	169-174
8189039-12	1994	In addition, colocalization of ADA and CP on the brush border of cells in the S3 segment of proximal tubules provides support for the hypothesis that one function of CP may be to position ADA on the plasma membrane of specific cell populations, further expanding the enzyme"s utility in nucleoside metabolism.	Nucleosides	287-297	adenosine deaminase	Oryctolagus cuniculus	31-34
8189039-12	1994	In addition, colocalization of ADA and CP on the brush border of cells in the S3 segment of proximal tubules provides support for the hypothesis that one function of CP may be to position ADA on the plasma membrane of specific cell populations, further expanding the enzyme"s utility in nucleoside metabolism.	Nucleosides	287-297	adenosine deaminase	Oryctolagus cuniculus	188-191
8151632-0	1994	Cytosolic 5"-nucleotidase/nucleoside phosphotransferase: a nucleoside analog activating enzyme?	Nucleosides	26-36	snake venom 5'-nucleotidase	Cricetulus griseus	10-25
8127867-1	1994	Reaction of synthetic N-(2"-deoxyguanosin-8-yl)-4-aminobiphenyl (dGuo-8-ABP) with t-butoxycarbonyl-L-[35S]methionine, N-hydroxysuccinimidyl ester (35S-labeled TBM-NHS), under optimized conditions produced mono-, bis-, and tris-TBM-acylated nucleosides that were separable by HPLC.	Nucleosides	240-251	amine oxidase copper containing 1	Homo sapiens	72-75
7507861-4	1994	It was further observed that GRE prevented the antiproliferative effects of cytosine arabinoside (Ara-C) and azadeoxycytidine, suggesting that GRE contained cytidine deaminase (CDD) activity, since CDD is known to abolish the effects of these nucleoside analogs.	Nucleosides	243-253	cytidine deaminase	Homo sapiens	177-180
7660980-0	1994	Production of adenosine and nucleoside analogues by an exchange reaction catalyzed by adenosine kinase.	Nucleosides	28-38	adenosine kinase	Homo sapiens	86-102
8293797-2	1994	In the present study it is shown that B-31 also acts as a specific inhibitor of the cellular uptake of nucleosides.	Nucleosides	103-114	cytohesin 1 interacting protein	Homo sapiens	38-42
7661022-0	1994	Modification of tumor necrosis factor (TNF) production and survival rate by a nucleoside mixture in lipopolysaccharide-injected rats.	Nucleosides	78-88	tumor necrosis factor-like	Rattus norvegicus	16-37
7661022-0	1994	Modification of tumor necrosis factor (TNF) production and survival rate by a nucleoside mixture in lipopolysaccharide-injected rats.	Nucleosides	78-88	tumor necrosis factor-like	Rattus norvegicus	39-42
8357543-1	1993	Supercoiling-induced structural transition of the d(C24GC21).d(G21CG24) sequence in plasmid DNA in the presence of Mg2+ at neutral pH results in alterations of efficiencies of not only single-quantum (pyrimidine[6-4]pyrimidone adducts) but also two-quantum (alkali-sensitive lesions of dG residues) photomodifications of nucleoside residues within this sequence.	Nucleosides	321-331	mucin 7, secreted	Homo sapiens	115-118
8373199-2	1993	In a clone of cells selected for expression of dihydrofolate reductase by the ability to grow in nucleoside-free medium the activity of glutathione peroxidase was reduced to 20% of the activity in the untransfected parental line of cells (DG44).	Nucleosides	97-107	dihydrofolate reductase	Cricetulus griseus	47-70
8374056-2	1993	Electrochemical oxidation of DBP in the presence of nucleosides leads to adducts from DBP.+.	Nucleosides	52-63	D-box binding PAR bZIP transcription factor	Homo sapiens	29-32
8374056-2	1993	Electrochemical oxidation of DBP in the presence of nucleosides leads to adducts from DBP.+.	Nucleosides	52-63	D-box binding PAR bZIP transcription factor	Homo sapiens	86-89
8218229-0	1993	Identification of important residues within the putative nucleoside binding site of HSV-1 thymidine kinase by random sequence selection: analysis of selected mutants in vitro.	Nucleosides	57-67	involved in nucleotide metabolism	Human alphaherpesvirus 1	90-106
8218229-1	1993	Random sequence mutagenesis in conjunction with genetic complementation was used to map the function of amino acid residues within the putative nucleoside binding site of the herpes simplex virus type 1 (HSV-1) thymidine kinase (TK).	Nucleosides	144-154	involved in nucleotide metabolism	Human alphaherpesvirus 1	211-227
8218229-1	1993	Random sequence mutagenesis in conjunction with genetic complementation was used to map the function of amino acid residues within the putative nucleoside binding site of the herpes simplex virus type 1 (HSV-1) thymidine kinase (TK).	Nucleosides	144-154	involved in nucleotide metabolism	Human alphaherpesvirus 1	229-231
7902361-4	1993	P-glycoprotein (P-gP) has been implicated as playing a role in multidrug (MDR) resistance in cancer, chloroquine-resistant Plasmodium falciparum infection, and possibly human immunodeficiency virus-1 (HIV-1) resistance to nucleoside compounds.	Nucleosides	222-232	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
7902361-4	1993	P-glycoprotein (P-gP) has been implicated as playing a role in multidrug (MDR) resistance in cancer, chloroquine-resistant Plasmodium falciparum infection, and possibly human immunodeficiency virus-1 (HIV-1) resistance to nucleoside compounds.	Nucleosides	222-232	phosphoglycolate phosphatase	Homo sapiens	16-20
8335084-2	1993	10(-5) M Thymidine inhibited EL4 cell replication and decreased cell viability after 12-24 h. The effect was highly specific for this nucleoside.	Nucleosides	134-144	epilepsy 4	Mus musculus	29-32
8497256-6	1993	Missing-nucleoside analysis demonstrated that the third and fourth nGAAn sites were essential for mHSF1 and mHSF2 binding.	Nucleosides	8-18	heat shock factor 1	Mus musculus	98-103
8491790-0	1993	CSF-1 stimulates nucleoside transport in S1 macrophages.	Nucleosides	17-27	colony stimulating factor 1 (macrophage)	Mus musculus	0-5
8491790-1	1993	We have examined nucleoside transport (NT) in a cell line derived from primary day 7 murine bone marrow macrophages (S1 macrophages) in response to the macrophage growth factor, colony-stimulating factor 1 (CSF-1).	Nucleosides	17-27	colony stimulating factor 1 (macrophage)	Mus musculus	178-205
8491790-1	1993	We have examined nucleoside transport (NT) in a cell line derived from primary day 7 murine bone marrow macrophages (S1 macrophages) in response to the macrophage growth factor, colony-stimulating factor 1 (CSF-1).	Nucleosides	17-27	colony stimulating factor 1 (macrophage)	Mus musculus	207-212
7689685-2	1993	Not only have we learned about how modified nucleosides affect the performance of tRNA in translation, but also how they influence regulation of intermediary metabolism, antibiotics production, gene expression in eukaryotic viruses, cell division, cell-cycle control, u.v.	Nucleosides	44-55	mitochondrially encoded tRNA glycine	Homo sapiens	82-86
8497256-6	1993	Missing-nucleoside analysis demonstrated that the third and fourth nGAAn sites were essential for mHSF1 and mHSF2 binding.	Nucleosides	8-18	heat shock factor 2	Mus musculus	108-113
8457194-1	1993	The elevation of adenosine levels induced by anoxia in isolated rat hepatocytes has been shown to result mainly from an arrest of the recycling of the nucleoside by adenosine kinase [Bontemps, Vincent and Van den Berghe (1993) Biochem.	Nucleosides	151-161	adenosine kinase	Rattus norvegicus	165-181
8496926-3	1993	These nucleosides were linked via their spacer functionality to HSA.	Nucleosides	6-17	albumin	Homo sapiens	64-67
8384443-1	1993	Previous work has shown that normoxic isolated rat hepatocytes continuously produce adenosine from AMP and that the nucleoside is not catabolized further but immediately rephosphorylated by adenosine kinase [Bontemps, Van den Berghe and Hers (1983) Proc.	Nucleosides	116-126	adenosine kinase	Rattus norvegicus	190-206
8460920-9	1993	The use of GM-CSF and zidovudine may represent a viable treatment option for persons with human immunodeficiency virus infection who develop neutropenia while receiving zidovudine but do not tolerate alternative nucleoside analogs.	Nucleosides	212-222	colony stimulating factor 2	Homo sapiens	11-17
8392160-1	1993	The nucleoside analog acyclovir is remarkably effective and selective in herpes simplex virus (HSF) infections.	Nucleosides	4-14	interleukin 6	Homo sapiens	95-98
8487759-0	1993	[The role of oligophosphate and nucleoside fragments upon the interaction of a nucleotide with RecA protein].	Nucleosides	32-42	RAD51 recombinase	Homo sapiens	95-99
8422376-1	1993	Deoxycytidine kinase is a key enzyme in the salvage pathway, and its activity is required for 5"-phosphorylation of several important antiviral and cytostatic nucleoside analogues.	Nucleosides	159-169	deoxycytidine kinase	Homo sapiens	0-20
8434108-4	1993	The plots of radiation dose-yield and corresponding calculated G values of the released undamaged bases and nucleosides from d-[CpT] and d-[TpC] suggest a base-sequence dependence and a quality- and quantity-dependent response to ionizing radiation.	Nucleosides	108-119	choline phosphotransferase 1	Homo sapiens	128-131
8483469-0	1993	[Synthesis of nucleoside analogs containing a cis-2-pentene fragment and their triphosphates].	Nucleosides	14-24	suppressor of cytokine signaling 2	Homo sapiens	46-51
8421671-1	1993	Deoxycytidine kinase (NTP:deoxycytidine 5"-phosphotransferase, EC 2.7.1.74) is an enzyme that catalyzes phosphorylation of deoxyribonucleosides and a number of nucleoside analogs that are important in antiviral and cancer chemotherapy.	Nucleosides	132-142	deoxycytidine kinase	Homo sapiens	0-20
8440150-2	1993	The mouse mammary solid tumor MCaK was labeled in vivo by intraperitoneal injection of the nucleosides.	Nucleosides	91-102	kinesin family member 2C	Mus musculus	30-34
8245880-7	1993	It has recently been shown with another nucleoside analogue, ganciclovir, active against human cytomegalovirus (HMCV), that activation can be carried out by other unrelated kinases (in this case the UL97 gene product).	Nucleosides	40-50	tegument serine/threonine protein kinase	Human betaherpesvirus 5	199-203
1282702-6	1992	The ability of rev to bind to RBC6 analogues containing functional group modifications on base and sugar moieties of nucleoside residues was also examined.	Nucleosides	117-127	Rev	Human immunodeficiency virus 1	15-18
1445943-3	1992	The analysis of the kinetic parameters of bovine lens purine nucleoside phosphorylase, determined both for the phosphorolytic activity on nucleosides and for ribosylating activity on purine bases, indicates the occurrence of a rapid equilibrium random Bi-Bi mechanism with formation of abortive complexes.	Nucleosides	138-149	purine nucleoside phosphorylase	Bos taurus	54-85
1489095-5	1992	The immunoassay of dCK could prove useful in the selection and monitoring of patients who are being treated with nucleosides that are activated by this enzyme.	Nucleosides	113-124	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	19-22
1335091-1	1992	Tumor cells infected with a retrovirus vector (VIK) containing the herpes simplex virus thymidine kinase (HSV-TK) gene can be selectively killed by treatment with nucleoside analogues, such as ganciclovir.	Nucleosides	163-173	zinc finger protein 655	Homo sapiens	47-50
1489095-1	1992	Deoxycytidine kinase (dCK) is necessary for the activity of several nucleosides used for the chemotherapy of cancer and AIDS.	Nucleosides	68-79	deoxycytidine kinase	Homo sapiens	0-20
1489095-1	1992	Deoxycytidine kinase (dCK) is necessary for the activity of several nucleosides used for the chemotherapy of cancer and AIDS.	Nucleosides	68-79	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	22-25
1337428-1	1992	Two enzymes participating in 2"-deoxyadenosine (dAdo) metabolism: dAdo kinase (dAdoK EC 2.7.1.76) and adenosine deaminase (ADA, EC 3.5.4.4) were partially purified from rat liver mitochondria and cytosol and influence of nucleosides and nucleotides on the activity of these enzymes were investigated.	Nucleosides	221-232	adenosine deaminase	Rattus norvegicus	102-121
1337428-1	1992	Two enzymes participating in 2"-deoxyadenosine (dAdo) metabolism: dAdo kinase (dAdoK EC 2.7.1.76) and adenosine deaminase (ADA, EC 3.5.4.4) were partially purified from rat liver mitochondria and cytosol and influence of nucleosides and nucleotides on the activity of these enzymes were investigated.	Nucleosides	221-232	adenosine deaminase	Rattus norvegicus	123-126
1445204-10	1992	The control patterns of these five fluxes indicate that, in the presence of extracellular adenosine and inosine, the intracellular metabolism of adenine derivatives would be highly dependent on the extracellular and intracellular concentrations of both nucleosides, on the ectoenzymes (5"-nucleotidase and adenosine deaminase) and on the transporter.	Nucleosides	253-264	5'-nucleotidase ecto	Homo sapiens	286-301
1445204-10	1992	The control patterns of these five fluxes indicate that, in the presence of extracellular adenosine and inosine, the intracellular metabolism of adenine derivatives would be highly dependent on the extracellular and intracellular concentrations of both nucleosides, on the ectoenzymes (5"-nucleotidase and adenosine deaminase) and on the transporter.	Nucleosides	253-264	adenosine deaminase	Homo sapiens	306-325
1406603-9	1992	Of the three nucleoside analogs tested, dFdC was the most efficient dCK substrate.	Nucleosides	13-23	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	68-71
1530662-0	1992	Inhibition of poly(ADP-ribose)polymerase activity by nucleoside analogs of thymidine.	Nucleosides	53-63	poly(ADP-ribose) polymerase 1	Homo sapiens	14-40
1530662-4	1992	The structural requirements for these nucleoside analogs to be inhibitors of PARP were determined.	Nucleosides	38-48	poly(ADP-ribose) polymerase 1	Homo sapiens	77-81
1325999-8	1992	These results indicate that luminal degradation of cAMP into adenosine, followed by cellular uptake of the nucleoside by tubular cells, is a key event which accounts for the phosphaturic effect of exogenous cAMP and for the part of the phosphaturic effect of PTH which is mediated by cAMP added to the tubular lumen under the influence of the hormone.	Nucleosides	107-117	parathyroid hormone	Rattus norvegicus	259-262
1330897-4	1992	On the other hand, if IL-2 acts on B cells together with or after cAMP, it synergizes with the nucleoside and enhances the immune response.	Nucleosides	95-105	interleukin 2	Mus musculus	22-26
1380648-3	1992	TGF-alpha mRNA accumulated, however, in response to DNA demethylation induced by a nucleoside analog, 5-azacytidine (5-azaC).	Nucleosides	83-93	transforming growth factor alpha	Homo sapiens	0-9
1599494-4	1992	The present studies with intact human erythrocytes demonstrate that nucleoside analogues which inhibit SAH-hydrolase caused substantial attenuation of adenine transfer from dAdo into ATP.	Nucleosides	68-78	ado	Drosophila melanogaster	173-177
1505028-2	1992	Missing nucleoside experiments showed that SATB1 selectively binds in a special AT-rich sequence context where one strand consists of mixed A"s, T"s, and C"s, excluding G"s (ATC sequences).	Nucleosides	8-18	SATB homeobox 1	Homo sapiens	43-48
1430786-0	1992	A novel non-radioactive method for detection of nucleoside analog phosphorylation by 5"-nucleotidase.	Nucleosides	48-58	5'-nucleotidase ecto	Homo sapiens	85-100
1430786-1	1992	Cytosolic 5"-nucleotidase has been implicated in the phosphorylation of certain nucleosides of therapeutic interest.	Nucleosides	80-91	5'-nucleotidase ecto	Homo sapiens	10-25
1430786-3	1992	Existing assays for nucleoside phosphorylation effected by 5"-nucleotidase require a radiolabeled nucleoside as the phosphate acceptor and separation of the substrate-nucleoside from product-nucleotide has been accomplished either by a filter binding method or HPLC.	Nucleosides	20-30	5'-nucleotidase ecto	Homo sapiens	59-74
1430786-3	1992	Existing assays for nucleoside phosphorylation effected by 5"-nucleotidase require a radiolabeled nucleoside as the phosphate acceptor and separation of the substrate-nucleoside from product-nucleotide has been accomplished either by a filter binding method or HPLC.	Nucleosides	98-108	5'-nucleotidase ecto	Homo sapiens	59-74
1430786-3	1992	Existing assays for nucleoside phosphorylation effected by 5"-nucleotidase require a radiolabeled nucleoside as the phosphate acceptor and separation of the substrate-nucleoside from product-nucleotide has been accomplished either by a filter binding method or HPLC.	Nucleosides	98-108	5'-nucleotidase ecto	Homo sapiens	59-74
1430786-4	1992	However, detection of the phosphorylation of unlabeled nucleoside by HPLC is difficult since the ultraviolet absorbance of the phosphate donor, IMP, frequently obscures the absorbance of newly formed nucleotide.	Nucleosides	55-65	inositol monophosphatase 1	Homo sapiens	144-147
1319559-0	1992	Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir.	Nucleosides	98-108	tegument serine/threonine protein kinase	Human betaherpesvirus 5	22-26
24243047-5	1992	With model C-8 substituted arylamine adducts [N-(deoxyguanosin-8-yl)-4-aminobiphenyl, N-(deoxyadenosin--yl)-4-aminobiphenyl, and N-(deoxyguanosin-8-yl)-2-aminofluorene], nucleoside-specific and carcinogen-specific fragmentation have been observed in daughter ion spectra.	Nucleosides	170-180	homeobox C8	Homo sapiens	11-14
1496834-2	1992	The bases were liberated from nucleic acids, nucleotides, and nucleosides by acid hydrolysis with trifluoroacetic and formic acid (1/1, V/V) at 240 degrees C in a pressure-digestion system.	Nucleosides	62-73	mediator complex subunit 25	Homo sapiens	125-139
1535254-1	1992	Ecto-5"-nucleotidase (ecto-5"-NUC, EC 3.1.3.5., CD73) is a plasma membrane enzyme, which catalyzes the hydrolytic dephosphorylation of purine nucleotides to the corresponding nucleosides so that they can pass through the plasma membrane.	Nucleosides	175-186	5'-nucleotidase ecto	Homo sapiens	0-20
1544389-1	1992	At suboptimal concentrations of granulocyte-macrophage colony-stimulating factor (GM-CSF), nucleobases and nucleosides as well as their analogues strongly stimulated aggregate (colony and cluster) formation from murine bone marrow granulocyte-macrophage colony-forming units (CFU-GM) in agar culture.	Nucleosides	107-118	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	82-88
1601953-1	1992	The enzyme 5"-nucleotidase (5"-ribonucleotide phosphohydrolase, EC 3.1.3.5) catalyzes a critical reaction in intermediary metabolism, the phosphohydrolysis of nucleoside 5"-monophosphates to their corresponding nucleosides.	Nucleosides	211-222	5'-nucleotidase ecto	Homo sapiens	11-26
1441846-6	1992	Among the natural nucleoside and deoxynucleotide derivatives tested, deoxy-GTP and UTP inhibited only cytosolic adenosine deaminase by 60% and 40%, respectively.	Nucleosides	18-28	adenosine deaminase	Rattus norvegicus	112-131
1586132-0	1992	Kinetic properties of the common electrophoretic variants of human S-adenosylhomocysteine hydrolase (AHCY): the effect of four nucleoside analogue inhibitors.	Nucleosides	127-137	adenosylhomocysteinase	Homo sapiens	67-99
1586132-0	1992	Kinetic properties of the common electrophoretic variants of human S-adenosylhomocysteine hydrolase (AHCY): the effect of four nucleoside analogue inhibitors.	Nucleosides	127-137	adenosylhomocysteinase	Homo sapiens	101-105
1625596-6	1992	We propose that the other nucleosides and deoxyribonucleosides inhibit extracellular adenosine deaminase, thereby increasing the extracellular concentration of adenosine.	Nucleosides	26-37	adenosine deaminase	Rattus norvegicus	85-104
1731884-6	1992	Two of the nucleosides studied, 1-deazapurine riboside and 1-deaza-adenosine, form complexes which appear to mimic a ground-state rather than a reactive intermediate when bound to adenosine deaminase.	Nucleosides	11-22	adenosine deaminase	Homo sapiens	180-199
1535254-1	1992	Ecto-5"-nucleotidase (ecto-5"-NUC, EC 3.1.3.5., CD73) is a plasma membrane enzyme, which catalyzes the hydrolytic dephosphorylation of purine nucleotides to the corresponding nucleosides so that they can pass through the plasma membrane.	Nucleosides	175-186	5'-nucleotidase ecto	Homo sapiens	22-33
1535254-1	1992	Ecto-5"-nucleotidase (ecto-5"-NUC, EC 3.1.3.5., CD73) is a plasma membrane enzyme, which catalyzes the hydrolytic dephosphorylation of purine nucleotides to the corresponding nucleosides so that they can pass through the plasma membrane.	Nucleosides	175-186	5'-nucleotidase ecto	Homo sapiens	48-52
1939152-7	1991	Missing nucleoside positions specifically enriched in the unbound fraction of RNA are located in the two strands that comprise loop E. These are not necessarily sites of sequence-specific contacts, but rather may constitute a region of secondary structure essential to recognition and binding of TFIIIA to 5 S rRNA.	Nucleosides	8-18	general transcription factor 3A L homeolog	Xenopus laevis	296-302
1920637-1	1991	This report describes the use of a recombinant murine retrovirus encoding beta-galactosidase (PLJ beta-gal retrovirus) to study the antiretroviral activity of zidovudine (AZT) and other nucleoside analogs.	Nucleosides	186-196	galactosidase, beta 1	Mus musculus	74-92
1930225-2	1991	This unexpected result provides evidence that the variations in the glycosyl torsion angle between nucleosides in solution are less that those which have previously been reported in crystals and it is an experimental basis for analyzing the syn and anti populations from chemical shift and coupling constant data.	Nucleosides	99-110	synemin	Homo sapiens	241-244