PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20844237-0	2010	8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma.	8-aminoadenosine	0-16	AKT serine/threonine kinase 1	Homo sapiens	26-29
20844237-0	2010	8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma.	8-aminoadenosine	0-16	mechanistic target of rapamycin kinase	Homo sapiens	30-34
20844237-0	2010	8-Aminoadenosine inhibits Akt/mTOR and Erk signaling in mantle cell lymphoma.	8-aminoadenosine	0-16	mitogen-activated protein kinase 1	Homo sapiens	39-42
20844237-1	2010	8-Aminoadenosine (8-NH(2)-Ado), a ribosyl nucleoside analog, in preclinical models of multiple myeloma inhibits phosphorylation of proteins in multiple growth and survival pathways, including Akt.	8-aminoadenosine	0-16	AKT serine/threonine kinase 1	Homo sapiens	192-195
20053765-9	2010	RNA polymerase II COOH terminal domain phosphorylation declined sharply in 8-amino-adenosine-treated cells, which may have been due to the lack of an ATP phosphate donor or competitive inhibition with 8-amino-ATP at CDK7 and CDK9.	8-aminoadenosine	75-92	cyclin dependent kinase 7	Homo sapiens	216-220
20053765-9	2010	RNA polymerase II COOH terminal domain phosphorylation declined sharply in 8-amino-adenosine-treated cells, which may have been due to the lack of an ATP phosphate donor or competitive inhibition with 8-amino-ATP at CDK7 and CDK9.	8-aminoadenosine	75-92	cyclin dependent kinase 9	Homo sapiens	225-229
26416444-8	2015	We therefore tested a chemotherapeutic agent (8-amino-adenosine) that induces p53-independent cell death for higher clinically relevant cytotoxicity.	8-aminoadenosine	46-63	tumor protein p53	Homo sapiens	78-81
26416444-9	2015	We demonstrated that T/T and G/G mdm2 SNP309 cells were equally sensitive to 8-amino-adenosine induced cell death.	8-aminoadenosine	77-94	MDM2 proto-oncogene	Homo sapiens	33-37
15827330-0	2005	8-Amino-adenosine induces loss of phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2, and Akt kinase: role in induction of apoptosis in multiple myeloma.	8-aminoadenosine	0-17	mitogen-activated protein kinase 14	Homo sapiens	53-56
15827330-0	2005	8-Amino-adenosine induces loss of phosphorylation of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2, and Akt kinase: role in induction of apoptosis in multiple myeloma.	8-aminoadenosine	0-17	mitogen-activated protein kinase 3	Homo sapiens	91-148
25815140-0	2015	Identification of 8-aminoadenosine derivatives as a new class of human concentrative nucleoside transporter 2 inhibitors.	8-aminoadenosine	18-34	solute carrier family 28 member 2	Homo sapiens	71-109
25815140-6	2015	Here we describe significant findings about structural requirements of 8-aminoadenosine derivatives for exhibiting potent hCNT2 inhibitory activity.	8-aminoadenosine	71-87	solute carrier family 28 member 2	Homo sapiens	122-127
22973058-0	2012	8-Amino-adenosine activates p53-independent cell death of metastatic breast cancers.	8-aminoadenosine	0-17	tumor protein p53	Homo sapiens	28-31
22448923-0	2012	Multifaceted actions of 8-amino-adenosine kill BCR-ABL positive cells.	8-aminoadenosine	24-41	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	47-54
22448923-2	2012	We hypothesized that 8-amino-adenosine (8-amino-Ado)-mediated reduction in cellular ATP level and inhibition of mRNA synthesis leading to a decrease in protein level would result in a multifaceted targeting of BCR-ABL.	8-aminoadenosine	21-38	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	210-217
22448923-2	2012	We hypothesized that 8-amino-adenosine (8-amino-Ado)-mediated reduction in cellular ATP level and inhibition of mRNA synthesis leading to a decrease in protein level would result in a multifaceted targeting of BCR-ABL.	8-aminoadenosine	40-51	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	210-217
22448923-4	2012	In parallel, 8-amino-Ado inhibited RNA synthesis and resulted in a depletion of BCR-ABL transcript.	8-aminoadenosine	13-24	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	80-87