PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24463545-5	2014	The docked pose of 3HNA in the free protein and in OA bound albumins (ternary systems) and the concomitant perturbation of the structure of proteins around the binding region of 3HNA corroborate the enhanced ESIPT emission of 3HNA and the energy transfer efficiency from the donor Trp213 of BSA to 3HNA acceptor in 3HNA-OA-BSA system.	3-hydroxy-2-naphthoic acid	178-182	albumin	Homo sapiens	323-326
18293954-1	2008	The steady-state and time-resolved studies of the sensitized emission of the excited-state proton transfer (ESIPT) probe 3-hydroxy-2-naphthoic acid (3HNA) when bound to bovine serum albumin (BSA) and human serum albumin (HSA) indicate that the nonradiative dipole-dipole Forster type energy transfer from Trp singlet state of proteins to the ESIPT singlet state of 3HNA is greater in the case of HSA.	3-hydroxy-2-naphthoic acid	121-147	albumin	Homo sapiens	176-195
24463545-1	2014	The binding site and the binding mechanism of 3-hydroxy-2-naphthoic acid (3HNA) in oleic acid (OA) bound serum albumins (bovine serum albumin (BSA) and human serum albumin (HSA)) have been determined using steady state and time resolved emission of tryptophan residues (Trp) in proteins and the ESIPT emission of 3HNA.	3-hydroxy-2-naphthoic acid	46-72	albumin	Homo sapiens	128-147
24463545-1	2014	The binding site and the binding mechanism of 3-hydroxy-2-naphthoic acid (3HNA) in oleic acid (OA) bound serum albumins (bovine serum albumin (BSA) and human serum albumin (HSA)) have been determined using steady state and time resolved emission of tryptophan residues (Trp) in proteins and the ESIPT emission of 3HNA.	3-hydroxy-2-naphthoic acid	46-72	albumin	Homo sapiens	158-178
24463545-1	2014	The binding site and the binding mechanism of 3-hydroxy-2-naphthoic acid (3HNA) in oleic acid (OA) bound serum albumins (bovine serum albumin (BSA) and human serum albumin (HSA)) have been determined using steady state and time resolved emission of tryptophan residues (Trp) in proteins and the ESIPT emission of 3HNA.	3-hydroxy-2-naphthoic acid	74-78	albumin	Homo sapiens	128-147
24463545-1	2014	The binding site and the binding mechanism of 3-hydroxy-2-naphthoic acid (3HNA) in oleic acid (OA) bound serum albumins (bovine serum albumin (BSA) and human serum albumin (HSA)) have been determined using steady state and time resolved emission of tryptophan residues (Trp) in proteins and the ESIPT emission of 3HNA.	3-hydroxy-2-naphthoic acid	74-78	albumin	Homo sapiens	158-178
24463545-5	2014	The docked pose of 3HNA in the free protein and in OA bound albumins (ternary systems) and the concomitant perturbation of the structure of proteins around the binding region of 3HNA corroborate the enhanced ESIPT emission of 3HNA and the energy transfer efficiency from the donor Trp213 of BSA to 3HNA acceptor in 3HNA-OA-BSA system.	3-hydroxy-2-naphthoic acid	19-23	albumin	Homo sapiens	291-294
24463545-5	2014	The docked pose of 3HNA in the free protein and in OA bound albumins (ternary systems) and the concomitant perturbation of the structure of proteins around the binding region of 3HNA corroborate the enhanced ESIPT emission of 3HNA and the energy transfer efficiency from the donor Trp213 of BSA to 3HNA acceptor in 3HNA-OA-BSA system.	3-hydroxy-2-naphthoic acid	19-23	albumin	Homo sapiens	323-326
24463545-5	2014	The docked pose of 3HNA in the free protein and in OA bound albumins (ternary systems) and the concomitant perturbation of the structure of proteins around the binding region of 3HNA corroborate the enhanced ESIPT emission of 3HNA and the energy transfer efficiency from the donor Trp213 of BSA to 3HNA acceptor in 3HNA-OA-BSA system.	3-hydroxy-2-naphthoic acid	178-182	albumin	Homo sapiens	291-294
24463545-5	2014	The docked pose of 3HNA in the free protein and in OA bound albumins (ternary systems) and the concomitant perturbation of the structure of proteins around the binding region of 3HNA corroborate the enhanced ESIPT emission of 3HNA and the energy transfer efficiency from the donor Trp213 of BSA to 3HNA acceptor in 3HNA-OA-BSA system.	3-hydroxy-2-naphthoic acid	178-182	albumin	Homo sapiens	323-326
24463545-5	2014	The docked pose of 3HNA in the free protein and in OA bound albumins (ternary systems) and the concomitant perturbation of the structure of proteins around the binding region of 3HNA corroborate the enhanced ESIPT emission of 3HNA and the energy transfer efficiency from the donor Trp213 of BSA to 3HNA acceptor in 3HNA-OA-BSA system.	3-hydroxy-2-naphthoic acid	178-182	albumin	Homo sapiens	291-294
24463545-5	2014	The docked pose of 3HNA in the free protein and in OA bound albumins (ternary systems) and the concomitant perturbation of the structure of proteins around the binding region of 3HNA corroborate the enhanced ESIPT emission of 3HNA and the energy transfer efficiency from the donor Trp213 of BSA to 3HNA acceptor in 3HNA-OA-BSA system.	3-hydroxy-2-naphthoic acid	178-182	albumin	Homo sapiens	323-326
24463545-5	2014	The docked pose of 3HNA in the free protein and in OA bound albumins (ternary systems) and the concomitant perturbation of the structure of proteins around the binding region of 3HNA corroborate the enhanced ESIPT emission of 3HNA and the energy transfer efficiency from the donor Trp213 of BSA to 3HNA acceptor in 3HNA-OA-BSA system.	3-hydroxy-2-naphthoic acid	178-182	albumin	Homo sapiens	291-294
23812398-6	2013	UPR markers such as GRP78, C/EBP homology protein (CHOP) and phosphorylated protein kinase RNA-activated (PKR)-like ER kinase (PERK) were significantly down-regulated with hydroxynaphthoic acids in western blot.	3-hydroxy-2-naphthoic acid	172-194	heat shock protein family A (Hsp70) member 5	Homo sapiens	20-25
23812398-6	2013	UPR markers such as GRP78, C/EBP homology protein (CHOP) and phosphorylated protein kinase RNA-activated (PKR)-like ER kinase (PERK) were significantly down-regulated with hydroxynaphthoic acids in western blot.	3-hydroxy-2-naphthoic acid	172-194	DNA damage inducible transcript 3	Homo sapiens	27-49
23812398-6	2013	UPR markers such as GRP78, C/EBP homology protein (CHOP) and phosphorylated protein kinase RNA-activated (PKR)-like ER kinase (PERK) were significantly down-regulated with hydroxynaphthoic acids in western blot.	3-hydroxy-2-naphthoic acid	172-194	DNA damage inducible transcript 3	Homo sapiens	51-55
23812398-6	2013	UPR markers such as GRP78, C/EBP homology protein (CHOP) and phosphorylated protein kinase RNA-activated (PKR)-like ER kinase (PERK) were significantly down-regulated with hydroxynaphthoic acids in western blot.	3-hydroxy-2-naphthoic acid	172-194	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	127-131
23812398-8	2013	Further, both phosphorylated inositol-requiring enzyme 1alpha (IRE1alpha) and spliced form of X-box binding protein 1 (XBP1) were decreased in the protein and the mRNA level, implying both PERK and IRE1alpha branches in UPR mechanism are controlled with hydroxynaphthoic acids.	3-hydroxy-2-naphthoic acid	254-276	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	63-72
23812398-8	2013	Further, both phosphorylated inositol-requiring enzyme 1alpha (IRE1alpha) and spliced form of X-box binding protein 1 (XBP1) were decreased in the protein and the mRNA level, implying both PERK and IRE1alpha branches in UPR mechanism are controlled with hydroxynaphthoic acids.	3-hydroxy-2-naphthoic acid	254-276	X-box binding protein 1	Homo sapiens	94-117
23812398-8	2013	Further, both phosphorylated inositol-requiring enzyme 1alpha (IRE1alpha) and spliced form of X-box binding protein 1 (XBP1) were decreased in the protein and the mRNA level, implying both PERK and IRE1alpha branches in UPR mechanism are controlled with hydroxynaphthoic acids.	3-hydroxy-2-naphthoic acid	254-276	X-box binding protein 1	Homo sapiens	119-123
18293954-3	2008	The docking studies of the complex of BSA-3HNA also indicate that Trp 134 rather than Trp 213 is involved in the energy transfer process.	3-hydroxy-2-naphthoic acid	42-46	albumin	Homo sapiens	38-41
18293954-4	2008	The local environment of Trp 134 in BSA rather than that of Trp 213 is perturbed because of interaction with 3HNA as revealed by the optical resolution of Trp 134 phosphorescence in the complex at 77 K. Docking studies support the larger rotational correlation time, thetac (approximately 50 ns), observed for Trp residue/residues in the complexes of HSA and BSA compared with that in the free proteins.	3-hydroxy-2-naphthoic acid	109-113	albumin	Homo sapiens	36-39
18293954-4	2008	The local environment of Trp 134 in BSA rather than that of Trp 213 is perturbed because of interaction with 3HNA as revealed by the optical resolution of Trp 134 phosphorescence in the complex at 77 K. Docking studies support the larger rotational correlation time, thetac (approximately 50 ns), observed for Trp residue/residues in the complexes of HSA and BSA compared with that in the free proteins.	3-hydroxy-2-naphthoic acid	109-113	albumin	Homo sapiens	351-354
18293954-4	2008	The local environment of Trp 134 in BSA rather than that of Trp 213 is perturbed because of interaction with 3HNA as revealed by the optical resolution of Trp 134 phosphorescence in the complex at 77 K. Docking studies support the larger rotational correlation time, thetac (approximately 50 ns), observed for Trp residue/residues in the complexes of HSA and BSA compared with that in the free proteins.	3-hydroxy-2-naphthoic acid	109-113	albumin	Homo sapiens	359-362
18293954-1	2008	The steady-state and time-resolved studies of the sensitized emission of the excited-state proton transfer (ESIPT) probe 3-hydroxy-2-naphthoic acid (3HNA) when bound to bovine serum albumin (BSA) and human serum albumin (HSA) indicate that the nonradiative dipole-dipole Forster type energy transfer from Trp singlet state of proteins to the ESIPT singlet state of 3HNA is greater in the case of HSA.	3-hydroxy-2-naphthoic acid	121-147	albumin	Homo sapiens	206-225
18293954-1	2008	The steady-state and time-resolved studies of the sensitized emission of the excited-state proton transfer (ESIPT) probe 3-hydroxy-2-naphthoic acid (3HNA) when bound to bovine serum albumin (BSA) and human serum albumin (HSA) indicate that the nonradiative dipole-dipole Forster type energy transfer from Trp singlet state of proteins to the ESIPT singlet state of 3HNA is greater in the case of HSA.	3-hydroxy-2-naphthoic acid	121-147	albumin	Homo sapiens	221-224
18293954-1	2008	The steady-state and time-resolved studies of the sensitized emission of the excited-state proton transfer (ESIPT) probe 3-hydroxy-2-naphthoic acid (3HNA) when bound to bovine serum albumin (BSA) and human serum albumin (HSA) indicate that the nonradiative dipole-dipole Forster type energy transfer from Trp singlet state of proteins to the ESIPT singlet state of 3HNA is greater in the case of HSA.	3-hydroxy-2-naphthoic acid	149-153	albumin	Homo sapiens	176-195
18293954-1	2008	The steady-state and time-resolved studies of the sensitized emission of the excited-state proton transfer (ESIPT) probe 3-hydroxy-2-naphthoic acid (3HNA) when bound to bovine serum albumin (BSA) and human serum albumin (HSA) indicate that the nonradiative dipole-dipole Forster type energy transfer from Trp singlet state of proteins to the ESIPT singlet state of 3HNA is greater in the case of HSA.	3-hydroxy-2-naphthoic acid	149-153	albumin	Homo sapiens	206-225
18293954-1	2008	The steady-state and time-resolved studies of the sensitized emission of the excited-state proton transfer (ESIPT) probe 3-hydroxy-2-naphthoic acid (3HNA) when bound to bovine serum albumin (BSA) and human serum albumin (HSA) indicate that the nonradiative dipole-dipole Forster type energy transfer from Trp singlet state of proteins to the ESIPT singlet state of 3HNA is greater in the case of HSA.	3-hydroxy-2-naphthoic acid	149-153	albumin	Homo sapiens	221-224
33523571-8	2021	In a comparative study, the IC50 value (50% inhibition of fibril formation) of NQDA in inhibiting the aggregation of PHF6 (25 microM) was ~17 microM, which is lower than for other bona-fide amyloid inhibitors, naphthoquinone-tryptophan, rosmarinic acid, epigallocatechin gallate, ~21 microM, ~77 microM or ~19 microM, respectively.	3-hydroxy-2-naphthoic acid	180-184	PHD finger protein 6	Homo sapiens	117-121