PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21321118-6	2011	In addition, we found that oxidation of TE by peroxynitrite (ONOO(-)) prevented binding of SMCs and WI-38 cells and other elastogenic cells, human dermal fibroblasts and fetal bovine chondrocytes.	onoo(	61-66	elastin	Homo sapiens	40-42
21740411-12	2012	CONCLUSIONS AND IMPLICATIONS: Our data indicate that the oxidative species ONOO(-) and H(2) O(2) increase arginase activity/expression through PKC-mediated activation of RhoA/Rho kinase pathway.	onoo(	75-80	ras homolog family member A	Bos taurus	170-174
21598373-1	2011	Oxidation of dihydrorhodamine 123 (DHR) to rhodamine 123 (RH) by oxoperoxonitrite (ONOO(-)), formed through recombination of NO and O(2)( -) radicals resulting from thermal decomposition of 3-morpholinosydnonimine (SIN-1) in buffered aerated aqueous solution at pH 7.6, represents a kinetic model system of the reactivity of NO and O(2)( -) in biochemical systems.	onoo(	83-88	MAPK associated protein 1	Homo sapiens	215-220
25180249-3	2014	5-fluoroisatin was used to non-invasively detect ONOO(-) formation in living lung epithelial cells stimulated with interferon-gamma (IFN-gamma).	onoo(	49-54	interferon gamma	Homo sapiens	115-131
25180249-3	2014	5-fluoroisatin was used to non-invasively detect ONOO(-) formation in living lung epithelial cells stimulated with interferon-gamma (IFN-gamma).	onoo(	49-54	interferon gamma	Homo sapiens	133-142
21487413-3	2011	ROS/RNS cause structural membrane damage, induce inflammation, and scavenge nitric oxide (NO) to yield peroxynitrite (ONOO(-)).	onoo(	118-123	FAM20C golgi associated secretory pathway kinase	Homo sapiens	4-7
21321118-10	2011	Mass spectrometric and circular dichroism spectroscopic analyses showed that ONOO(-) treatment modified both Cys residues in the CT-25 peptide to sulfonic acid derivatives, without altering the secondary structure.	onoo(	77-82	BAGE family member 5	Homo sapiens	129-134
19817443-3	2009	We present the preparation and demonstration of a fluorogenic sensor for monitoring peroxynitrite (ONOO(-)) and myeloperoxidase (MPO) mediated hypochlorous acid (HOCl/OCl(-)) production.	onoo(	99-104	occludin	Mus musculus	163-166
20518849-8	2011	In vitro degradation of human recombinant MLC1 by MMP-2 increased after ONOO(-) exposure of MLC1 in a concentration-dependent manner.	onoo(	72-77	myosin light chain 1	Homo sapiens	42-46
20518849-8	2011	In vitro degradation of human recombinant MLC1 by MMP-2 increased after ONOO(-) exposure of MLC1 in a concentration-dependent manner.	onoo(	72-77	matrix metallopeptidase 2	Homo sapiens	50-55
20518849-8	2011	In vitro degradation of human recombinant MLC1 by MMP-2 increased after ONOO(-) exposure of MLC1 in a concentration-dependent manner.	onoo(	72-77	myosin light chain 1	Homo sapiens	92-96
19226281-12	2009	Statins showed anti-atherosclerotic effects mediated by HO-1/eNOS, restoring the [NO]/[ONOO(-)] imbalance and reducing lipid peroxidation.	onoo(	87-92	heme oxygenase 1	Oryctolagus cuniculus	56-60
17635921-7	2007	Conversely, activation of AMPK by pharmacologic (nicotine, ONOO(-), metformin, and AICAR) or genetic (overexpression of constitutively active AMPK) means inhibited FAS activity.	onoo(	59-64	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	26-30
15289284-14	2004	GEA 3162 and SIN-1 oxidised the O(2)(-)- and ONOO(-)-sensitive dye, dihydrorhodamine 123 (DHR 123; 1 microm), suggesting that ONOO(-) released from these compounds is responsible for oxidation of DHR 123.	onoo(	45-50	MAPK associated protein 1	Homo sapiens	13-18
16556649-7	2006	Western blot analysis using anti-nitrotyrosine antibodies recognized nitrotyrosine-containing proteins in 20 and 50 kDa bands in BY-2 protein extract containing SIN-1 [3-(4-morpholinyl) sydnonimine hydrochloride; an ONOO(-) donor].	onoo(	216-221	F-box protein PP2-B11-like	Nicotiana tabacum	129-133
16556649-7	2006	Western blot analysis using anti-nitrotyrosine antibodies recognized nitrotyrosine-containing proteins in 20 and 50 kDa bands in BY-2 protein extract containing SIN-1 [3-(4-morpholinyl) sydnonimine hydrochloride; an ONOO(-) donor].	onoo(	216-221	MAPK associated protein 1	Homo sapiens	161-166
15794661-8	2005	An immunoblot study with anti-nitrotyrosine antibody revealed that ONOO(-) induces nitration of tyrosine residues in PKCalpha.	onoo(	67-72	protein kinase C alpha	Bos taurus	117-125
17635921-7	2007	Conversely, activation of AMPK by pharmacologic (nicotine, ONOO(-), metformin, and AICAR) or genetic (overexpression of constitutively active AMPK) means inhibited FAS activity.	onoo(	59-64	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	142-146
16386761-4	2006	Furthermore, GSH was detected by HPLC from the MGST1 which was incubated with ONOO(-) plus GSH or S-nitrosoglutathione followed by DTT treatment.	onoo(	78-83	microsomal glutathione S-transferase 1	Rattus norvegicus	47-52
12044177-2	2002	Previous studies have shown that aconitase/IRP-1 may be a target of *NO or peroxynitrite (ONOO(-)), formed after reaction of *NO with superoxide anion (O(2)(*-)); however, the mechanisms and consequences of such interactions have remained uncertain.	onoo(	90-95	aconitase 1	Mus musculus	43-48
12044177-12	2002	These results indicate that *NO and ONOO(-) may activate IRP-1 by attacking the Fe-S cluster of cytoplasmic aconitase, while also inactivating the cluster-deficient IRP-2.	onoo(	36-41	aconitase 1	Mus musculus	57-62
12044177-12	2002	These results indicate that *NO and ONOO(-) may activate IRP-1 by attacking the Fe-S cluster of cytoplasmic aconitase, while also inactivating the cluster-deficient IRP-2.	onoo(	36-41	aconitase 1	Mus musculus	96-117
12044177-12	2002	These results indicate that *NO and ONOO(-) may activate IRP-1 by attacking the Fe-S cluster of cytoplasmic aconitase, while also inactivating the cluster-deficient IRP-2.	onoo(	36-41	iron responsive element binding protein 2	Mus musculus	165-170
11520063-3	2001	However, brief incubation of either hippocampal homogenates or purified PKC with peroxynitrite (ONOO(-)) inhibited cofactor-dependent PKC activity in a manner that correlated with the nitration of tyrosine residues on PKC, suggesting that this modification was responsible for the inhibition of PKC.	onoo(	96-101	protein kinase C, alpha	Rattus norvegicus	72-75
11520063-3	2001	However, brief incubation of either hippocampal homogenates or purified PKC with peroxynitrite (ONOO(-)) inhibited cofactor-dependent PKC activity in a manner that correlated with the nitration of tyrosine residues on PKC, suggesting that this modification was responsible for the inhibition of PKC.	onoo(	96-101	protein kinase C, alpha	Rattus norvegicus	134-137
11520063-3	2001	However, brief incubation of either hippocampal homogenates or purified PKC with peroxynitrite (ONOO(-)) inhibited cofactor-dependent PKC activity in a manner that correlated with the nitration of tyrosine residues on PKC, suggesting that this modification was responsible for the inhibition of PKC.	onoo(	96-101	protein kinase C, alpha	Rattus norvegicus	134-137
11520063-3	2001	However, brief incubation of either hippocampal homogenates or purified PKC with peroxynitrite (ONOO(-)) inhibited cofactor-dependent PKC activity in a manner that correlated with the nitration of tyrosine residues on PKC, suggesting that this modification was responsible for the inhibition of PKC.	onoo(	96-101	protein kinase C, alpha	Rattus norvegicus	134-137
10575026-7	1999	Bicarbonate protected TH from ONOO(-)-induced inactivation and sulfhydryl oxidation but increased significantly tyrosine nitration.	onoo(	30-35	tyrosine hydroxylase	Homo sapiens	22-24