PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34329860-8	2021	From the docking and molecular dynamics study, it was revealed that the bioactives namely amritoside, apigenin-6-C-glucosyl7-O-glucoside, pectolinarin and astragalin showed better binding affinities with COVID-19 Mpro.	saponarin	102-136	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	213-217
24011529-1	2014	This study investigated the hepatoprotective activity of saponarin, isolated from Gypsophila trichotoma Wend., using in vitro/in vivo hepatotoxicity model based on carbone tetrachloride (CCl4)-induced liver damage in male Wistar rats.	saponarin	57-66	C-C motif chemokine ligand 4	Rattus norvegicus	187-191
34445132-7	2021	Saponarin (100 muM) also significantly induced the expression of hyaluronan synthase-3, aquaporin 3, and cathelicidin antimicrobial peptide (LL-37) in HaCaT cells, which play an important role as skin barriers.	saponarin	0-9	aquaporin 3 (Gill blood group)	Homo sapiens	88-99
34445132-7	2021	Saponarin (100 muM) also significantly induced the expression of hyaluronan synthase-3, aquaporin 3, and cathelicidin antimicrobial peptide (LL-37) in HaCaT cells, which play an important role as skin barriers.	saponarin	0-9	cathelicidin antimicrobial peptide	Homo sapiens	105-139
34445132-7	2021	Saponarin (100 muM) also significantly induced the expression of hyaluronan synthase-3, aquaporin 3, and cathelicidin antimicrobial peptide (LL-37) in HaCaT cells, which play an important role as skin barriers.	saponarin	0-9	cathelicidin antimicrobial peptide	Homo sapiens	141-146
26471090-0	2015	Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5.	saponarin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	20-24
26471090-0	2015	Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5.	saponarin	0-9	CREB regulated transcription coactivator 2	Homo sapiens	138-143
26471090-0	2015	Saponarin activates AMPK in a calcium-dependent manner and suppresses gluconeogenesis and increases glucose uptake via phosphorylation of CRTC2 and HDAC5.	saponarin	0-9	histone deacetylase 5	Homo sapiens	148-153
26471090-2	2015	Saponarin suppressed the rate of gluconeogenesis and increased cellular glucose uptake in HepG2 and TE671 cells by regulating AMPK.	saponarin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	126-130
26471090-4	2015	Instead, saponarin increased intracellular calcium levels and induced AMPK phosphorylation, which was diminished by co-stimulation with STO-609, an inhibitor of CAMKKbeta.	saponarin	9-18	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	70-74
26471090-4	2015	Instead, saponarin increased intracellular calcium levels and induced AMPK phosphorylation, which was diminished by co-stimulation with STO-609, an inhibitor of CAMKKbeta.	saponarin	9-18	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	161-170
26471090-6	2015	This nuclear translocation was inhibited by increased phosphorylation of CRTC2 and HDAC5 by saponarin-induced AMPK in HepG2 cells and suppression of CREB and FoxO1 transactivation activities in cells stimulated by saponarin.	saponarin	92-101	CREB regulated transcription coactivator 2	Homo sapiens	73-78
26471090-6	2015	This nuclear translocation was inhibited by increased phosphorylation of CRTC2 and HDAC5 by saponarin-induced AMPK in HepG2 cells and suppression of CREB and FoxO1 transactivation activities in cells stimulated by saponarin.	saponarin	92-101	histone deacetylase 5	Homo sapiens	83-88
26471090-6	2015	This nuclear translocation was inhibited by increased phosphorylation of CRTC2 and HDAC5 by saponarin-induced AMPK in HepG2 cells and suppression of CREB and FoxO1 transactivation activities in cells stimulated by saponarin.	saponarin	92-101	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	110-114
26471090-6	2015	This nuclear translocation was inhibited by increased phosphorylation of CRTC2 and HDAC5 by saponarin-induced AMPK in HepG2 cells and suppression of CREB and FoxO1 transactivation activities in cells stimulated by saponarin.	saponarin	92-101	cAMP responsive element binding protein 1	Homo sapiens	149-153
26471090-6	2015	This nuclear translocation was inhibited by increased phosphorylation of CRTC2 and HDAC5 by saponarin-induced AMPK in HepG2 cells and suppression of CREB and FoxO1 transactivation activities in cells stimulated by saponarin.	saponarin	92-101	forkhead box O1	Homo sapiens	158-163
26471090-6	2015	This nuclear translocation was inhibited by increased phosphorylation of CRTC2 and HDAC5 by saponarin-induced AMPK in HepG2 cells and suppression of CREB and FoxO1 transactivation activities in cells stimulated by saponarin.	saponarin	214-223	CREB regulated transcription coactivator 2	Homo sapiens	73-78
34445132-3	2021	In lipopolysaccharide-induced RAW264.7 (murine macrophage) cells, saponarin (80 muM) significantly inhibited cytokine expression, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, inducible nitric oxide synthase, and cyclooxygenase (COX)-2.	saponarin	66-75	tumor necrosis factor	Mus musculus	140-173
34445132-3	2021	In lipopolysaccharide-induced RAW264.7 (murine macrophage) cells, saponarin (80 muM) significantly inhibited cytokine expression, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, inducible nitric oxide synthase, and cyclooxygenase (COX)-2.	saponarin	66-75	interleukin 1 alpha	Mus musculus	175-197
34445132-3	2021	In lipopolysaccharide-induced RAW264.7 (murine macrophage) cells, saponarin (80 muM) significantly inhibited cytokine expression, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, inducible nitric oxide synthase, and cyclooxygenase (COX)-2.	saponarin	66-75	nitric oxide synthase 2, inducible	Mus musculus	199-230
34445132-3	2021	In lipopolysaccharide-induced RAW264.7 (murine macrophage) cells, saponarin (80 muM) significantly inhibited cytokine expression, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, inducible nitric oxide synthase, and cyclooxygenase (COX)-2.	saponarin	66-75	cytochrome c oxidase II, mitochondrial	Mus musculus	236-258
34445132-4	2021	Saponarin (80 muM) also inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) and p38 involved in the mitogen-activated protein kinase signaling pathway in RAW264.7 cells.	saponarin	0-9	mitogen-activated protein kinase 1	Mus musculus	57-94
34445132-4	2021	Saponarin (80 muM) also inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) and p38 involved in the mitogen-activated protein kinase signaling pathway in RAW264.7 cells.	saponarin	0-9	mitogen-activated protein kinase 1	Mus musculus	96-99
34445132-4	2021	Saponarin (80 muM) also inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) and p38 involved in the mitogen-activated protein kinase signaling pathway in RAW264.7 cells.	saponarin	0-9	mitogen-activated protein kinase 14	Mus musculus	105-108
34445132-6	2021	In addition, saponarin (100 muM) significantly inhibited the expression of macrophage-derived chemokine, thymus and activation-regulated chemokine, IL-33, thymic stromal lymphopoietin, and the phosphorylation of signaling molecules (ERK, p38 and signal transducer and activator of transcription 1 (STAT1)) in TNF-alpha- and interferon (IFN)-gamma-stimulated HaCaT (human immortalized keratinocyte) cells.	saponarin	13-22	interleukin 33	Homo sapiens	148-153
34445132-6	2021	In addition, saponarin (100 muM) significantly inhibited the expression of macrophage-derived chemokine, thymus and activation-regulated chemokine, IL-33, thymic stromal lymphopoietin, and the phosphorylation of signaling molecules (ERK, p38 and signal transducer and activator of transcription 1 (STAT1)) in TNF-alpha- and interferon (IFN)-gamma-stimulated HaCaT (human immortalized keratinocyte) cells.	saponarin	13-22	mitogen-activated protein kinase 1	Homo sapiens	233-236
34445132-6	2021	In addition, saponarin (100 muM) significantly inhibited the expression of macrophage-derived chemokine, thymus and activation-regulated chemokine, IL-33, thymic stromal lymphopoietin, and the phosphorylation of signaling molecules (ERK, p38 and signal transducer and activator of transcription 1 (STAT1)) in TNF-alpha- and interferon (IFN)-gamma-stimulated HaCaT (human immortalized keratinocyte) cells.	saponarin	13-22	mitogen-activated protein kinase 14	Homo sapiens	238-241
34445132-6	2021	In addition, saponarin (100 muM) significantly inhibited the expression of macrophage-derived chemokine, thymus and activation-regulated chemokine, IL-33, thymic stromal lymphopoietin, and the phosphorylation of signaling molecules (ERK, p38 and signal transducer and activator of transcription 1 (STAT1)) in TNF-alpha- and interferon (IFN)-gamma-stimulated HaCaT (human immortalized keratinocyte) cells.	saponarin	13-22	signal transducer and activator of transcription 1	Homo sapiens	246-296
34445132-6	2021	In addition, saponarin (100 muM) significantly inhibited the expression of macrophage-derived chemokine, thymus and activation-regulated chemokine, IL-33, thymic stromal lymphopoietin, and the phosphorylation of signaling molecules (ERK, p38 and signal transducer and activator of transcription 1 (STAT1)) in TNF-alpha- and interferon (IFN)-gamma-stimulated HaCaT (human immortalized keratinocyte) cells.	saponarin	13-22	signal transducer and activator of transcription 1	Homo sapiens	298-303
34445132-6	2021	In addition, saponarin (100 muM) significantly inhibited the expression of macrophage-derived chemokine, thymus and activation-regulated chemokine, IL-33, thymic stromal lymphopoietin, and the phosphorylation of signaling molecules (ERK, p38 and signal transducer and activator of transcription 1 (STAT1)) in TNF-alpha- and interferon (IFN)-gamma-stimulated HaCaT (human immortalized keratinocyte) cells.	saponarin	13-22	tumor necrosis factor	Homo sapiens	309-318
34445132-6	2021	In addition, saponarin (100 muM) significantly inhibited the expression of macrophage-derived chemokine, thymus and activation-regulated chemokine, IL-33, thymic stromal lymphopoietin, and the phosphorylation of signaling molecules (ERK, p38 and signal transducer and activator of transcription 1 (STAT1)) in TNF-alpha- and interferon (IFN)-gamma-stimulated HaCaT (human immortalized keratinocyte) cells.	saponarin	13-22	interferon gamma	Homo sapiens	324-346
34445132-7	2021	Saponarin (100 muM) also significantly induced the expression of hyaluronan synthase-3, aquaporin 3, and cathelicidin antimicrobial peptide (LL-37) in HaCaT cells, which play an important role as skin barriers.	saponarin	0-9	hyaluronan synthase 3	Homo sapiens	65-86
26471090-6	2015	This nuclear translocation was inhibited by increased phosphorylation of CRTC2 and HDAC5 by saponarin-induced AMPK in HepG2 cells and suppression of CREB and FoxO1 transactivation activities in cells stimulated by saponarin.	saponarin	214-223	histone deacetylase 5	Homo sapiens	83-88
26471090-6	2015	This nuclear translocation was inhibited by increased phosphorylation of CRTC2 and HDAC5 by saponarin-induced AMPK in HepG2 cells and suppression of CREB and FoxO1 transactivation activities in cells stimulated by saponarin.	saponarin	214-223	cAMP responsive element binding protein 1	Homo sapiens	149-153
26471090-6	2015	This nuclear translocation was inhibited by increased phosphorylation of CRTC2 and HDAC5 by saponarin-induced AMPK in HepG2 cells and suppression of CREB and FoxO1 transactivation activities in cells stimulated by saponarin.	saponarin	214-223	forkhead box O1	Homo sapiens	158-163
26471090-9	2015	Collectively, these results suggest that saponarin activates AMPK in a calcium-dependent manner, thus regulating gluconeogenesis and glucose uptake.	saponarin	41-50	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	61-65
24011529-5	2014	Cell pre-incubation with saponarin (60-0.006 mug/ml) significantly ameliorated CCl4-induced hepatic damage in a concentration-dependent manner.	saponarin	25-34	C-C motif chemokine ligand 4	Rattus norvegicus	79-83
24011529-12	2014	However, pre-treatment with saponarin significantly increased enzyme activities in comparison to CCl4 only group.	saponarin	28-37	C-C motif chemokine ligand 4	Rattus norvegicus	97-101
24011529-14	2014	Our results suggest that saponarin, isolated from Gypsophila trichotoma Wend., showed in vitro and in vivo hepatoprotective and antioxidant activity against CCl4-induced liver damage.	saponarin	25-34	C-C motif chemokine ligand 4	Rattus norvegicus	157-161