PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2353832-3	1990	When rats were administered methyl isocyanate (MIC) by inhalation or subcutaneous route it produced severe hyperglycemia, clinical lactic acidosis, highly elevated plasma urea, and reduced plasma cholinesterase activity with unaltered erythrocyte acetyl cholinesterase activity.	methyl isocyanate	28-45	butyrylcholinesterase	Rattus norvegicus	196-210
8440870-3	1993	Methyl isocyanate administration led to haemoconcentration, resulting in an increase in the plasma concentration of total proteins and a decrease in both the plasma concentration of albumin and the plasma cholinesterase activity.	methyl isocyanate	0-17	butyrylcholinesterase	Rattus norvegicus	205-219
2353832-3	1990	When rats were administered methyl isocyanate (MIC) by inhalation or subcutaneous route it produced severe hyperglycemia, clinical lactic acidosis, highly elevated plasma urea, and reduced plasma cholinesterase activity with unaltered erythrocyte acetyl cholinesterase activity.	methyl isocyanate	28-45	butyrylcholinesterase	Rattus norvegicus	254-268
32233099-0	2020	Alleviation of methyl isocyanate-induced airway obstruction and mortality by tissue plasminogen activator.	methyl isocyanate	15-32	plasminogen activator, tissue type	Rattus norvegicus	77-105
2375780-1	1990	Derivatives of antitumour anthracycline antibiotics containing N-methylurea moiety in the carbohydrate ring were obtained by the interaction of methyl isocyanate with daunorubicin, doxorubicin, carminomycin and daunorubicin derivatives, substituted at C-13 or C-14 positions.	methyl isocyanate	144-161	homeobox C13	Homo sapiens	252-256
3689402-6	1987	Sequence analysis of cyanogen bromide peptides derived from methyl isocyanate-blocked lipid extract material produced two peptides which extended the amino acid sequence of SP-B to residue 79, which appears to be a glycine.	methyl isocyanate	60-77	surfactant protein B	Bos taurus	173-177
25068797-4	2014	Herein, we show that 1,2-bis(methylsulfonyl)-1-[(methylamino)carbonyl]hydrazine (101MDCE), an analog of laromustine that generates only methyl isocyanate, activates ASK1-JNK/p38 signaling in endothelial cells (EC).	methyl isocyanate	136-153	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	165-169
30426789-0	2019	Methyl isocyanate inhalation induces tissue factor-dependent activation of coagulation in rats.	methyl isocyanate	0-17	coagulation factor III, tissue factor	Rattus norvegicus	37-50
26625778-0	2015	In silico docking of methyl isocyanate (MIC) and its hydrolytic product (1, 3-dimethylurea) shows significant interaction with DNA Methyltransferase 1 suggests cancer risk in Bhopal-Gas- Tragedy survivors.	methyl isocyanate	21-38	DNA methyltransferase 1	Homo sapiens	127-150
25068797-4	2014	Herein, we show that 1,2-bis(methylsulfonyl)-1-[(methylamino)carbonyl]hydrazine (101MDCE), an analog of laromustine that generates only methyl isocyanate, activates ASK1-JNK/p38 signaling in endothelial cells (EC).	methyl isocyanate	136-153	mitogen-activated protein kinase 8	Homo sapiens	170-173
25068797-4	2014	Herein, we show that 1,2-bis(methylsulfonyl)-1-[(methylamino)carbonyl]hydrazine (101MDCE), an analog of laromustine that generates only methyl isocyanate, activates ASK1-JNK/p38 signaling in endothelial cells (EC).	methyl isocyanate	136-153	mitogen-activated protein kinase 14	Homo sapiens	174-177
25068797-9	2014	We conclude that methyl isocyanate induces dissociation of ASK1 from Trx1 either directly by carbamoylating the critical Cys groups in the ASK1-Trx1 complex or indirectly by inhibiting TrxR1.	methyl isocyanate	17-34	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	59-63
25068797-9	2014	We conclude that methyl isocyanate induces dissociation of ASK1 from Trx1 either directly by carbamoylating the critical Cys groups in the ASK1-Trx1 complex or indirectly by inhibiting TrxR1.	methyl isocyanate	17-34	thioredoxin	Homo sapiens	69-73
25068797-9	2014	We conclude that methyl isocyanate induces dissociation of ASK1 from Trx1 either directly by carbamoylating the critical Cys groups in the ASK1-Trx1 complex or indirectly by inhibiting TrxR1.	methyl isocyanate	17-34	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	139-143
25068797-9	2014	We conclude that methyl isocyanate induces dissociation of ASK1 from Trx1 either directly by carbamoylating the critical Cys groups in the ASK1-Trx1 complex or indirectly by inhibiting TrxR1.	methyl isocyanate	17-34	thioredoxin	Homo sapiens	144-148
25068797-9	2014	We conclude that methyl isocyanate induces dissociation of ASK1 from Trx1 either directly by carbamoylating the critical Cys groups in the ASK1-Trx1 complex or indirectly by inhibiting TrxR1.	methyl isocyanate	17-34	thioredoxin reductase 1	Homo sapiens	185-190
20601631-7	2010	TRPA1, a TRP ion channel expressed in chemosensory C-fibers, is activated by almost all oxidizing and electrophilic chemicals, including chlorine, acrolein, tear gas agents, and methyl isocyanate, the highly noxious chemical released in the Bhopal disaster.	methyl isocyanate	178-195	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-5
15857610-8	2005	The superior antineoplastic potential of Cloretazine compared to BCNU in animal models could be attributed in part to the contribution of the methyl isocyanate, which is synergistic with the co-generated cytotoxic alkylating species, while at the same time unable to significantly inhibit cellular GR.	methyl isocyanate	142-159	glutathione-disulfide reductase	Homo sapiens	298-300
12619763-0	2003	Diffusive sampling of methyl isocyanate using 4-nitro-7-piperazinobenzo-2-oxa-1,3-diazole (NBDPZ) as derivatizing agent.	methyl isocyanate	22-39	OXA1L mitochondrial inner membrane protein	Homo sapiens	74-79
19866438-5	2009	Among the 40 samples, 23, 11, and 10 showed p53, Rad50, and cyclin-E expression, respectively, in moderately differentiated adenocarcinomas, demonstrating the prevalence and invasiveness of this disease in the methyl isocyanate-exposed population (P = 0.0009).	methyl isocyanate	210-227	tumor protein p53	Homo sapiens	44-47
19866438-5	2009	Among the 40 samples, 23, 11, and 10 showed p53, Rad50, and cyclin-E expression, respectively, in moderately differentiated adenocarcinomas, demonstrating the prevalence and invasiveness of this disease in the methyl isocyanate-exposed population (P = 0.0009).	methyl isocyanate	210-227	RAD50 double strand break repair protein	Homo sapiens	49-54
19866438-7	2009	We conclude that there was altered expression of p53, Rad50, and cyclin-E in the malignant transformation of gallbladder carcinoma in this methyl isocyanate gas-exposed cohort.	methyl isocyanate	139-156	tumor protein p53	Homo sapiens	49-52
19866438-7	2009	We conclude that there was altered expression of p53, Rad50, and cyclin-E in the malignant transformation of gallbladder carcinoma in this methyl isocyanate gas-exposed cohort.	methyl isocyanate	139-156	RAD50 double strand break repair protein	Homo sapiens	54-59
10497941-6	1999	Carbamates produce [M+H-CONCH3]+ fragments by MS2 from neutral loss of methylisocyanate.	methyl isocyanate	71-87	MS2	Homo sapiens	46-49