PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 12901494-3 2001 Previously, we have found that sodium butyrate (NaBu) markedly enhanced the IL-4-induced IgE production in the LPS-stimulated murine splenocytes in vitro, and inductive rat IgE production in vivo, and enhanced the NK cell activity ex vivo. sethoxydim 48-52 interleukin 4 Mus musculus 76-80 12901494-7 2001 The spleen NK cell activity and IL-2- or IFN-gamma-induced spleen NK cell activity of mice treated/immunized with NaBu or/and ASC were stronger than those of untreated/unimmunized mice. sethoxydim 114-118 interleukin 2 Mus musculus 32-50 12901494-8 2001 Although IL-4 blocked IL-2 (100 U/ml)- or IFN-gamma (100 U/ml)-induced increase in NK cell activity, these NK cell activities in mice treated/immunized with NaBu/ASC were not inhibited. sethoxydim 157-161 interleukin 4 Mus musculus 9-13 12901494-8 2001 Although IL-4 blocked IL-2 (100 U/ml)- or IFN-gamma (100 U/ml)-induced increase in NK cell activity, these NK cell activities in mice treated/immunized with NaBu/ASC were not inhibited. sethoxydim 157-161 interleukin 2 Mus musculus 22-26 12901494-8 2001 Although IL-4 blocked IL-2 (100 U/ml)- or IFN-gamma (100 U/ml)-induced increase in NK cell activity, these NK cell activities in mice treated/immunized with NaBu/ASC were not inhibited. sethoxydim 157-161 interferon gamma Mus musculus 42-51 11368530-7 2001 Both NaBu and TSA caused a marked increase in the transactivation of plasmids containing 291 bp of the p21 promoter upstream of the transcriptional start site, similar to that previously seen for a 2.4-kb construct. sethoxydim 5-9 cyclin dependent kinase inhibitor 1A Homo sapiens 103-106 11368530-11 2001 HDAC1 blocked NaBu-mediated induction of all plasmids. sethoxydim 14-18 histone deacetylase 1 Homo sapiens 0-5 11027530-3 2000 Sodium butyrate (NaBu) and Trichostatin A (TSA) induced alkaline phosphatase activity and histone H4 acetylation in IEC-6 rat intestinal epithelial cells treated with or without interleukin-1beta (IL-1). sethoxydim 17-21 interleukin 1 beta Rattus norvegicus 178-195 11135429-8 2001 K23 mRNA was highly induced by NaBu in different pancreatic cancer cells. sethoxydim 31-35 keratin 23 Homo sapiens 0-3 11135429-10 2001 Treatment with either actinomycin D or cycloheximide efficiently blocked the induction of K23 mRNA by NaBu/TSA. sethoxydim 102-106 keratin 23 Homo sapiens 90-93 11135429-11 2001 These results indicate that K23 mRNA induction by NaBu or TSA is a downstream event of histone hyperacetylation. sethoxydim 50-54 keratin 23 Homo sapiens 28-31 11135429-12 2001 We also demonstrated that expression of p21(WAF1/CIP1) antisense RNA efficiently blocked the induction of K23 mRNA induced by NaBu. sethoxydim 126-130 cyclin dependent kinase inhibitor 1A Homo sapiens 40-43 11135429-12 2001 We also demonstrated that expression of p21(WAF1/CIP1) antisense RNA efficiently blocked the induction of K23 mRNA induced by NaBu. sethoxydim 126-130 cyclin dependent kinase inhibitor 1A Homo sapiens 44-48 11135429-12 2001 We also demonstrated that expression of p21(WAF1/CIP1) antisense RNA efficiently blocked the induction of K23 mRNA induced by NaBu. sethoxydim 126-130 cyclin dependent kinase inhibitor 1A Homo sapiens 49-53 11135429-12 2001 We also demonstrated that expression of p21(WAF1/CIP1) antisense RNA efficiently blocked the induction of K23 mRNA induced by NaBu. sethoxydim 126-130 keratin 23 Homo sapiens 106-109 11135429-14 2001 p21(WAF1/CIP1) serves as an important mediator during the induction process of K23 by NaBu. sethoxydim 86-90 cyclin dependent kinase inhibitor 1A Homo sapiens 0-3 11135429-14 2001 p21(WAF1/CIP1) serves as an important mediator during the induction process of K23 by NaBu. sethoxydim 86-90 cyclin dependent kinase inhibitor 1A Homo sapiens 4-8 11135429-14 2001 p21(WAF1/CIP1) serves as an important mediator during the induction process of K23 by NaBu. sethoxydim 86-90 cyclin dependent kinase inhibitor 1A Homo sapiens 9-13 11135429-14 2001 p21(WAF1/CIP1) serves as an important mediator during the induction process of K23 by NaBu. sethoxydim 86-90 keratin 23 Homo sapiens 79-82 11027530-4 2000 In contrast, both NaBu and TSA attenuated the IL-1-dependent induction of the acute phase protein gene haptoglobin, as well as C/EBPbeta and C/EBPdelta transcription factors mRNAs. sethoxydim 18-22 haptoglobin Rattus norvegicus 103-114 11027530-4 2000 In contrast, both NaBu and TSA attenuated the IL-1-dependent induction of the acute phase protein gene haptoglobin, as well as C/EBPbeta and C/EBPdelta transcription factors mRNAs. sethoxydim 18-22 CCAAT/enhancer binding protein beta Rattus norvegicus 127-136 11027530-5 2000 Gel shift and supershift assays showed a strong decrease in the IL-1-induced C/EBPbeta and C/EBPdelta containing complexes binding to the HaptoA C/EBP DNA-binding site of the haptoglobin promoter, by NaBu and TSA. sethoxydim 200-204 CCAAT/enhancer binding protein beta Rattus norvegicus 77-86 11027530-5 2000 Gel shift and supershift assays showed a strong decrease in the IL-1-induced C/EBPbeta and C/EBPdelta containing complexes binding to the HaptoA C/EBP DNA-binding site of the haptoglobin promoter, by NaBu and TSA. sethoxydim 200-204 CCAAT/enhancer binding protein delta Rattus norvegicus 91-101 11027530-5 2000 Gel shift and supershift assays showed a strong decrease in the IL-1-induced C/EBPbeta and C/EBPdelta containing complexes binding to the HaptoA C/EBP DNA-binding site of the haptoglobin promoter, by NaBu and TSA. sethoxydim 200-204 CCAAT/enhancer binding protein gamma Rattus norvegicus 77-82 11027530-5 2000 Gel shift and supershift assays showed a strong decrease in the IL-1-induced C/EBPbeta and C/EBPdelta containing complexes binding to the HaptoA C/EBP DNA-binding site of the haptoglobin promoter, by NaBu and TSA. sethoxydim 200-204 haptoglobin Rattus norvegicus 175-186 11027530-6 2000 Furthermore, site-specific mutation of the HaptoA site abolished the NaBu- and TSA-dependent inhibition of haptoglobin, as determined by transient transfection assays. sethoxydim 69-73 haptoglobin Rattus norvegicus 107-118 10193576-6 1999 These results showed that NaBu treatment supplemented with NAC not only inhibits apoptosis, but also exerts a synergistic effect on the biosynthesis of recombinant EPO. sethoxydim 26-30 erythropoietin Cricetulus griseus 164-167 11291028-5 2000 Compared with the SH2-0.32-Deltabcl-2 culture, under the condition of NaBu addition at the exponential growth phase, overexpression of the bcl-2 gene considerably suppressed the NaBu-induced apoptosis of 14C6-bcl-2 by inhibiting caspase 3 activity and extending culture longevity by >2 days. sethoxydim 178-182 apoptosis regulator Bcl-2 Cricetulus griseus 139-144 11291028-5 2000 Compared with the SH2-0.32-Deltabcl-2 culture, under the condition of NaBu addition at the exponential growth phase, overexpression of the bcl-2 gene considerably suppressed the NaBu-induced apoptosis of 14C6-bcl-2 by inhibiting caspase 3 activity and extending culture longevity by >2 days. sethoxydim 178-182 caspase-3 Cricetulus griseus 229-238 12110910-3 2000 Compared with the cells transfected with pDOR-neo empty vector, p21(WAF1) mRNA expression increased in 2BS-p21s cells, which were less sensitive to apoptosis induced by NaBu, and showed higher cell viability, delayed appearance of DNA ladder, and less area of apoptosis peak. sethoxydim 169-173 cyclin dependent kinase inhibitor 1A Homo sapiens 64-67 12110910-3 2000 Compared with the cells transfected with pDOR-neo empty vector, p21(WAF1) mRNA expression increased in 2BS-p21s cells, which were less sensitive to apoptosis induced by NaBu, and showed higher cell viability, delayed appearance of DNA ladder, and less area of apoptosis peak. sethoxydim 169-173 cyclin dependent kinase inhibitor 1A Homo sapiens 68-72 12110910-4 2000 On the other hand, p21(WAF1) mRNA expression decreased in 2BS-p21a cells, which were more sensitive to apoptosis induced by NaBu. sethoxydim 124-128 cyclin dependent kinase inhibitor 1A Homo sapiens 19-22 12110910-4 2000 On the other hand, p21(WAF1) mRNA expression decreased in 2BS-p21a cells, which were more sensitive to apoptosis induced by NaBu. sethoxydim 124-128 cyclin dependent kinase inhibitor 1A Homo sapiens 23-27 12110910-5 2000 These results indicated that the expression amount of p21(WAF1) in 2BS cells was negatively related with its susceptibility to apoptosis induced by NaBu. sethoxydim 148-152 cyclin dependent kinase inhibitor 1A Homo sapiens 54-57 12110910-5 2000 These results indicated that the expression amount of p21(WAF1) in 2BS cells was negatively related with its susceptibility to apoptosis induced by NaBu. sethoxydim 148-152 cyclin dependent kinase inhibitor 1A Homo sapiens 58-62 10746157-6 1999 Splenic B cells treated with NaBu, TSA and both together in the presence or absence of IL-2 showed almost the same increased acetylation level of histone H4. sethoxydim 29-33 interleukin 2 Mus musculus 87-91 10746157-7 1999 These results suggest that the NaBu-induced enhancement of anti-TNP antibody production in the presence of IL-2 is mediated through a moderate increase in the level of histone acetylation and that NaBu has both stimulating and inhibiting activities for anti-TNP antibody production, the latter of which is overcome by IL-2. sethoxydim 31-35 interleukin 2 Mus musculus 107-111 10746157-7 1999 These results suggest that the NaBu-induced enhancement of anti-TNP antibody production in the presence of IL-2 is mediated through a moderate increase in the level of histone acetylation and that NaBu has both stimulating and inhibiting activities for anti-TNP antibody production, the latter of which is overcome by IL-2. sethoxydim 31-35 interleukin 2 Mus musculus 318-322 10746157-7 1999 These results suggest that the NaBu-induced enhancement of anti-TNP antibody production in the presence of IL-2 is mediated through a moderate increase in the level of histone acetylation and that NaBu has both stimulating and inhibiting activities for anti-TNP antibody production, the latter of which is overcome by IL-2. sethoxydim 197-201 interleukin 2 Mus musculus 318-322 11291028-3 2000 To overcome this cytotoxic effect of NaBu, a survival protein, human Bcl-2, was overexpressed in recombinant Chinese hamster ovary (CHO) cells (SH2-0.32), producing a humanized antibody directed against the S surface antigen of hepatitis B virus. sethoxydim 37-41 BCL2 apoptosis regulator Homo sapiens 69-74 10746157-2 1999 NaBu dose dependently increased the acetylation levels of histone H4 at concentrations which effectively enhanced anti-trinitrophenyl (TNP) antibody production in the presence of IL-2. sethoxydim 0-4 interleukin 2 Mus musculus 179-183 10746157-3 1999 Among other short-chain fatty acids and NaBu analogs, propionate, valerate and vinylacetate were effective in the presence of IL-2 in increasing both antibody production and the histone H4 acetylation level, but acetate, alpha-, beta- and gamma-hydroxybutyrates and alpha-, beta- and gamma-aminobutyrates were not effective, even in the presence of IL-2. sethoxydim 40-44 interleukin 2 Mus musculus 126-130 10746157-4 1999 The effect of the specific histone deacetylase inhibitor trichostatin A (TSA), which enhances anti-TNP antibody production without IL-2, was markedly inhibited by adding NaBu simultaneously. sethoxydim 170-174 interleukin 2 Mus musculus 131-135 10935498-5 1999 The combination of TGF-beta1 and EGF also significantly induced COX-2 expression in rat intestinal epithelial (RIE-1) cells and completely prevented sodium butyrate (NaBu)-induced apoptosis. sethoxydim 166-170 transforming growth factor, beta 1 Rattus norvegicus 19-28 10935498-5 1999 The combination of TGF-beta1 and EGF also significantly induced COX-2 expression in rat intestinal epithelial (RIE-1) cells and completely prevented sodium butyrate (NaBu)-induced apoptosis. sethoxydim 166-170 epidermal growth factor Rattus norvegicus 33-36 10383164-4 1999 A novel cDNA designated carboxypeptidase A3 (CPA3), which was up-regulated in NaBu-treated PC-3 cells, was identified and characterized. sethoxydim 78-82 carboxypeptidase A3 Homo sapiens 24-43 10383164-4 1999 A novel cDNA designated carboxypeptidase A3 (CPA3), which was up-regulated in NaBu-treated PC-3 cells, was identified and characterized. sethoxydim 78-82 carboxypeptidase A3 Homo sapiens 45-49 10383164-9 1999 The consistent induction of CPA3 by NaBu in several prostate cancer cell lines led us to investigate the signaling pathway involved in the induction of CPA3 mRNA. sethoxydim 36-40 carboxypeptidase A3 Homo sapiens 28-32 10383164-12 1999 We also demonstrated that the induction of CPA3 mRNA by NaBu was inhibited by p21(WAF1/CIP1) antisense mRNA expression, indicating that p21 transactivation is required for the induction of CPA3 by NaBu. sethoxydim 56-60 carboxypeptidase A3 Homo sapiens 43-47 10383164-12 1999 We also demonstrated that the induction of CPA3 mRNA by NaBu was inhibited by p21(WAF1/CIP1) antisense mRNA expression, indicating that p21 transactivation is required for the induction of CPA3 by NaBu. sethoxydim 56-60 cyclin dependent kinase inhibitor 1A Homo sapiens 78-81 10383164-12 1999 We also demonstrated that the induction of CPA3 mRNA by NaBu was inhibited by p21(WAF1/CIP1) antisense mRNA expression, indicating that p21 transactivation is required for the induction of CPA3 by NaBu. sethoxydim 56-60 cyclin dependent kinase inhibitor 1A Homo sapiens 82-86 10383164-12 1999 We also demonstrated that the induction of CPA3 mRNA by NaBu was inhibited by p21(WAF1/CIP1) antisense mRNA expression, indicating that p21 transactivation is required for the induction of CPA3 by NaBu. sethoxydim 56-60 cyclin dependent kinase inhibitor 1A Homo sapiens 87-91 10383164-12 1999 We also demonstrated that the induction of CPA3 mRNA by NaBu was inhibited by p21(WAF1/CIP1) antisense mRNA expression, indicating that p21 transactivation is required for the induction of CPA3 by NaBu. sethoxydim 56-60 cyclin dependent kinase inhibitor 1A Homo sapiens 136-139 10383164-12 1999 We also demonstrated that the induction of CPA3 mRNA by NaBu was inhibited by p21(WAF1/CIP1) antisense mRNA expression, indicating that p21 transactivation is required for the induction of CPA3 by NaBu. sethoxydim 56-60 carboxypeptidase A3 Homo sapiens 189-193 10383164-12 1999 We also demonstrated that the induction of CPA3 mRNA by NaBu was inhibited by p21(WAF1/CIP1) antisense mRNA expression, indicating that p21 transactivation is required for the induction of CPA3 by NaBu. sethoxydim 197-201 carboxypeptidase A3 Homo sapiens 43-47 10383164-12 1999 We also demonstrated that the induction of CPA3 mRNA by NaBu was inhibited by p21(WAF1/CIP1) antisense mRNA expression, indicating that p21 transactivation is required for the induction of CPA3 by NaBu. sethoxydim 197-201 cyclin dependent kinase inhibitor 1A Homo sapiens 136-139 10383164-12 1999 We also demonstrated that the induction of CPA3 mRNA by NaBu was inhibited by p21(WAF1/CIP1) antisense mRNA expression, indicating that p21 transactivation is required for the induction of CPA3 by NaBu. sethoxydim 197-201 carboxypeptidase A3 Homo sapiens 189-193 10383164-13 1999 Our data demonstrate that the histone hyperacetylation signaling pathway is activated during NaBu-mediated differentiation of PC-3 cells, and the new gene, CPA3, is involved in this pathway. sethoxydim 93-97 carboxypeptidase A3 Homo sapiens 156-160 9826026-2 1998 NaBu markedly enhanced interleukin (IL)-6-induced IgM production with an accompanying increase in the level of histone H4 acetylation and augmented IgM production induced by IL-4 and phorbol 12-myristate 13-acetate. sethoxydim 0-4 interleukin 4 Homo sapiens 174-178 10098661-0 1999 Inhibition of 4-hydroxyphenylpyruvate dioxygenase by sethoxydim, a potent inhibitor of acetyl-coenzyme A carboxylase. sethoxydim 53-63 4-hydroxyphenylpyruvate dioxygenase Homo sapiens 14-49 10098661-1 1999 Sethoxydim, a commercially available cyclohexanedione class herbicide by targeting the enzymatic activity of acetyl-coenzyme A carboxylase, has been found to moderately inhibit the activity of 4-hydroxyphenylpyruvate dioxygenase, a key enzyme in the biosynthesis of plastoquinones and tocopherols in plants. sethoxydim 0-10 4-hydroxyphenylpyruvate dioxygenase Homo sapiens 193-228 9826026-6 1998 Thus another activity of NaBu in addition to the inhibition of histone deacetylase may be involved in promoting IL-6-induced differentiation. sethoxydim 25-29 interleukin 6 Homo sapiens 112-116 9548567-4 1998 NaBu in the concentration of 2-8 mM inhibited the growth of A5-DAP cells, and induced the expression of heat-stable PLAP. sethoxydim 0-4 death-associated protein Rattus norvegicus 63-66 9548567-4 1998 NaBu in the concentration of 2-8 mM inhibited the growth of A5-DAP cells, and induced the expression of heat-stable PLAP. sethoxydim 0-4 leucyl and cystinyl aminopeptidase Rattus norvegicus 116-120 9548567-7 1998 Exposure to 4 mM NaBu for 48 h increased the PLAP mRNA level by 31%. sethoxydim 17-21 leucyl and cystinyl aminopeptidase Rattus norvegicus 45-49 9548567-9 1998 Cells treated with NaBu released more PLAP than untreated cells in proportion to their elevated level of the enzyme. sethoxydim 19-23 leucyl and cystinyl aminopeptidase Rattus norvegicus 38-42 9548567-11 1998 NaBu inhibited the growth of A5-BAG cells also, and increased the beta-galactosidase level. sethoxydim 0-4 galactosidase, beta 1 Rattus norvegicus 66-84 9467754-5 1997 Addition of T-cells or the concanavalin A supernatant (CAS) from murine splenocytes to the B cell cultures completely restored the enhancing effect of NaBu. sethoxydim 151-155 chromosome segregation 1-like (S. cerevisiae) Mus musculus 55-58 9467754-7 1997 The full enhancing effect of NaBu was also detected when IL-2 was added to the B cell cultures, while IL-2 alone had no stimulatory effect on the control PFC response. sethoxydim 29-33 interleukin 2 Mus musculus 57-61 9467754-8 1997 IL-1 beta alone significantly stimulated the antibody production and adding NaBu to this IL-1 beta-supplemented culture caused a further increase. sethoxydim 76-80 interleukin 1 beta Mus musculus 89-98 9467754-11 1997 These results suggest that NaBu is an agent that promotes B cell differentiation in vitro in an IL-2-dependent manner. sethoxydim 27-31 interleukin 2 Mus musculus 96-100 8827437-1 1996 We previously reported the augmentation by sodium butyrate (NaBu) of IL-4-induced IgE production in LPS-stimulated murine B-lymphocytes. sethoxydim 60-64 interleukin 4 Mus musculus 69-73 8827437-3 1996 Thus, this study was accomplished to examine the involvement of histone hyperacetylation in IL-4-induced class switching promotion by NaBu with a specific histone deacetylase inhibitor, trichostatin A (TSA). sethoxydim 134-138 interleukin 4 Mus musculus 92-96 8827437-7 1996 Furthermore, enhancement of IgE production by TSA or NaBu was confirmed to be absolutely IL-4 dependent and was not due to the shift of kinetics. sethoxydim 53-57 interleukin 4 Mus musculus 89-93 8827437-9 1996 These findings suggest that histone hyperacetylation plays an important regulatory role in the modification of IL-4-dependent class switching to C epsilon in LPS-stimulated murine B-cells by NaBu. sethoxydim 191-195 interleukin 4 Mus musculus 111-115 8298162-6 1993 However, SPC-A1/DM4 cells, after recovery from the cytostasis induced by 2 days treatment with 2 mM NaBu, became 2-fold more sensitive to MMC than the cells not exposed to the agent. sethoxydim 100-104 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 9-15 35280546-7 2022 NaBu reduced cell viability and potentially induced GSH, but decreased SOD enzyme activity and the level of MDA and NO decreased also H2O2 decreased at different times and NaBu concentrations. sethoxydim 0-4 superoxide dismutase 1 Homo sapiens 71-74 24202589-6 1992 Seedling tolerance to herbicide treatments cosegregated with reduced inhibition of seedling leaf ACCase activity by sethoxydim and haloxyfop demonstrating that alterations of ACCase conferred herbicide tolerance. sethoxydim 116-126 acetyl-coenzyme A carboxylase Zea mays 97-103 24202589-6 1992 Seedling tolerance to herbicide treatments cosegregated with reduced inhibition of seedling leaf ACCase activity by sethoxydim and haloxyfop demonstrating that alterations of ACCase conferred herbicide tolerance. sethoxydim 116-126 acetyl-coenzyme A carboxylase Zea mays 175-181 24202589-7 1992 Therefore, we propose that at least three, and possible five, new alleles of the maize ACCase structural gene (Acc1) were identified based on their differential response to sethoxydim and haloxyfop. sethoxydim 173-183 acetyl-coenzyme A carboxylase Zea mays 87-93 24202589-7 1992 Therefore, we propose that at least three, and possible five, new alleles of the maize ACCase structural gene (Acc1) were identified based on their differential response to sethoxydim and haloxyfop. sethoxydim 173-183 acetyl-coenzyme A carboxylase Zea mays 111-115 24202589-8 1992 The group represented by Acc1-S1, Acc1-S2 and Acc1-S3 alleles, which had similar phenotypes, exhibited tolerance to high rates of sethoxydim and haloxyfop. sethoxydim 130-140 acetyl-coenzyme A carboxylase Zea mays 25-29 24202589-8 1992 The group represented by Acc1-S1, Acc1-S2 and Acc1-S3 alleles, which had similar phenotypes, exhibited tolerance to high rates of sethoxydim and haloxyfop. sethoxydim 130-140 acetyl-coenzyme A carboxylase Zea mays 34-38 24202589-8 1992 The group represented by Acc1-S1, Acc1-S2 and Acc1-S3 alleles, which had similar phenotypes, exhibited tolerance to high rates of sethoxydim and haloxyfop. sethoxydim 130-140 acetyl-coenzyme A carboxylase Zea mays 34-38 24202589-9 1992 The Acc1-H1 allele lacked sethoxydim tolerance but was tolerant to haloxyfop, whereas the Acc1-H2 allele had intermediate tolerance to sethoxydim but was tolerant to haloxyfop. sethoxydim 26-36 acetyl-coenzyme A carboxylase Zea mays 4-8 35429101-7 2022 The modulatory effects of NaBu on glycolysis, proliferation and apoptosis were related to its modulation of hexokinase 2 (HK2). sethoxydim 26-30 hexokinase 2 Mus musculus 108-120 35429101-7 2022 The modulatory effects of NaBu on glycolysis, proliferation and apoptosis were related to its modulation of hexokinase 2 (HK2). sethoxydim 26-30 hexokinase 2 Mus musculus 122-125 35429101-8 2022 NaBu downregulated HK2 expression via c-myc signalling. sethoxydim 0-4 hexokinase 2 Mus musculus 19-22 35429101-10 2022 Thus, NaBu inhibits the expression of HK2 to downregulate aerobic glycolysis and the proliferation of HCC cells and induces their apoptosis via the c-myc pathway. sethoxydim 6-10 hexokinase 2 Mus musculus 38-41 1634113-3 1992 Addition of sodium butyrate (NaBu) to the cell growth medium induced APRT activity ten- to 20-fold above wild-type levels in both transient and stable transfectants. sethoxydim 29-33 adenine phosphoribosyltransferase Homo sapiens 69-73 1634113-4 1992 The introduction of the APRT native promoter between the MoMSV enhancer-promoter and structural gene reduced the magnitude of the NaBu response. sethoxydim 130-134 adenine phosphoribosyltransferase Homo sapiens 24-28 1634113-7 1992 Northern analysis and nuclear run-on experiments indicated that NaBu enhanced transcription of APRT mRNA in both transiently and stably transfected cells, but not in cells inhibited by cycloheximide. sethoxydim 64-68 adenine phosphoribosyltransferase Homo sapiens 95-99 19912783-1 1991 Effects of second messenger system modulation and sodium butyrate (NaBu) treatment on nicotinic acetylcholine receptor (nAChR) expression by cells of the TE671/RD human clone were established. sethoxydim 67-71 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 86-118 1976254-7 1990 ACCase activity from homozygous tolerant plants required greater than 100-fold more sethoxydim and 16-fold more haloxyfop for 50% inhibition than ACCase from wild-type plants. sethoxydim 84-94 acetyl-coenzyme A carboxylase Zea mays 0-6 1976254-8 1990 These results indicate that tolerance to sethoxydim and haloxyfop is controlled by a partially dominant nuclear mutation encoding a herbicide-insensitive alteration in maize ACCase. sethoxydim 41-51 acetyl-coenzyme A carboxylase Zea mays 174-180 16667393-6 1990 Sethoxydim and haloxyfop concentrations that inhibited ACCase by 50% were similar for BMS, B10S, B50S, and B100S. sethoxydim 0-10 acetyl-coenzyme A carboxylase Zea mays 55-61 35499693-7 2022 According to qPCR data, the 3D culture of NaBu-treated MSCs has shown significant upregulation of hepatic gene, CK-18 (P < 0.01), and hepatic proteins, AFP (P < 0.01) and ALB (P < 0.01). sethoxydim 42-46 keratin 18 Homo sapiens 112-117 35499693-7 2022 According to qPCR data, the 3D culture of NaBu-treated MSCs has shown significant upregulation of hepatic gene, CK-18 (P < 0.01), and hepatic proteins, AFP (P < 0.01) and ALB (P < 0.01). sethoxydim 42-46 alpha fetoprotein Homo sapiens 152-155 35499693-7 2022 According to qPCR data, the 3D culture of NaBu-treated MSCs has shown significant upregulation of hepatic gene, CK-18 (P < 0.01), and hepatic proteins, AFP (P < 0.01) and ALB (P < 0.01). sethoxydim 42-46 albumin Homo sapiens 171-174 33356962-5 2021 We demonstrated that NaBu (0.2 mM intraimplant) treatment enhanced the neovascularization process, blood flow, and VEGF levels in a GPR43-dependent manner in the implants. sethoxydim 21-25 vascular endothelial growth factor A Mus musculus 115-119 2891354-4 1987 Acetyl coenzyme A carboxylase (EC 6.4.1.2) from corn seedling chloroplasts was inhibited by both sethoxydim and haloxyfop, with I50 values of 2.9 and 0.5 microM, respectively. sethoxydim 97-107 acetyl-coenzyme A carboxylase Zea mays 0-29 35178357-7 2021 The expressions of CCAT2 and HULC lncRNAs genes have significantly decreased in the presence of NaBu (P <0.05) in both PC3 and LNCAP cell lines, in comparison with the control. sethoxydim 96-100 colon cancer associated transcript 2 Homo sapiens 19-24 35178357-7 2021 The expressions of CCAT2 and HULC lncRNAs genes have significantly decreased in the presence of NaBu (P <0.05) in both PC3 and LNCAP cell lines, in comparison with the control. sethoxydim 96-100 hepatocellular carcinoma up-regulated long non-coding RNA Homo sapiens 29-33 33883448-4 2021 The present work aims to evaluate the effect of sodium butyrate (NaBu), an HDAC inhibitor, on behavioral markers of extinction and biochemical changes in HDAC and acetylcholinesterase activity in the hippocampus. sethoxydim 65-69 acetylcholinesterase Rattus norvegicus 163-183 33356962-5 2021 We demonstrated that NaBu (0.2 mM intraimplant) treatment enhanced the neovascularization process, blood flow, and VEGF levels in a GPR43-dependent manner in the implants. sethoxydim 21-25 free fatty acid receptor 2 Mus musculus 132-137 33356962-6 2021 Moreover, NaBu was able to modulate matrix remodeling aspects of the granulation tissue such as proteoglycans production, collagen deposition and alpha-SMA expression in vivo, besides to increase TGF-b1 levels in the fibrovascular tissue, in a GPR43-dependent manner. sethoxydim 10-14 actin alpha 2, smooth muscle, aorta Mus musculus 146-155 33356962-6 2021 Moreover, NaBu was able to modulate matrix remodeling aspects of the granulation tissue such as proteoglycans production, collagen deposition and alpha-SMA expression in vivo, besides to increase TGF-b1 levels in the fibrovascular tissue, in a GPR43-dependent manner. sethoxydim 10-14 transforming growth factor, beta 1 Mus musculus 196-202 33356962-6 2021 Moreover, NaBu was able to modulate matrix remodeling aspects of the granulation tissue such as proteoglycans production, collagen deposition and alpha-SMA expression in vivo, besides to increase TGF-b1 levels in the fibrovascular tissue, in a GPR43-dependent manner. sethoxydim 10-14 free fatty acid receptor 2 Mus musculus 244-249 33356962-7 2021 Interestingly, NaBu directly stimulated L929 murine fibroblasts migration, and TGF-beta1 and collagen production in vitro. sethoxydim 15-19 transforming growth factor, beta 1 Mus musculus 79-88 33356962-9 2021 Overall, our findings evidence that the metabolite-sensing receptor GPR43 contributes to the effects of low dose of NaBu in inducing angiogenesis and matrix remodeling during granulation tissue formation. sethoxydim 116-120 free fatty acid receptor 2 Homo sapiens 68-73 32908237-1 2021 Our recent work demonstrates that infusion of sodium butyrate (NaBu) into the renal medulla blunts angiotensin II-induced hypertension and improves renal injury. sethoxydim 63-67 angiotensinogen Rattus norvegicus 99-113 32908237-8 2021 Mechanistically, NaBu inhibited the protein levels of several sodium transporters stimulated by DOCA/salt in vivo, such as betaENaC, gammaENaC, NCC, and NKCC-2. sethoxydim 17-21 solute carrier family 12 member 1 Rattus norvegicus 153-159 32908237-9 2021 Further examination showed that NaBu downregulated the expression of mineralocorticoid receptor (MR) and serum and glucocorticoid-dependent protein kinase 1 (SGK1) in DOCA/salt-treated rats or aldosterone-treated human renal tubular duct epithelial cells. sethoxydim 32-36 serum/glucocorticoid regulated kinase 1 Rattus norvegicus 158-162 32908237-10 2021 These results provide evidence that NaBu may attenuate DOCA/salt-induced hypertension and renal damage by inhibiting the MR/SGK1 pathway. sethoxydim 36-40 serum/glucocorticoid regulated kinase 1 Homo sapiens 124-128 33187557-9 2020 Besides, the disruption of caspase 7 had negative effects on cell viability in exposure with NaBu which confirmed by MTT assay. sethoxydim 93-97 caspase-7 Cricetulus griseus 27-36 31565858-2 2019 The present work is aimed to investigate the effect of NaBu on angiotensin II (Ang II)-induced cardiac hypertrophy and the underlying mechanism in in vivo and in vitro models. sethoxydim 55-59 angiotensinogen Rattus norvegicus 63-77 32125592-7 2020 NaBu treatment was also able to decrease mast cell recruitment/activation and the levels of CXCL1, CCL2, IL-6, TNF-alpha, and TGF-beta1 in the implants but did not alter the levels of IL-10. sethoxydim 0-4 chemokine (C-X-C motif) ligand 1 Mus musculus 92-97 32125592-7 2020 NaBu treatment was also able to decrease mast cell recruitment/activation and the levels of CXCL1, CCL2, IL-6, TNF-alpha, and TGF-beta1 in the implants but did not alter the levels of IL-10. sethoxydim 0-4 chemokine (C-C motif) ligand 2 Mus musculus 99-103 32125592-7 2020 NaBu treatment was also able to decrease mast cell recruitment/activation and the levels of CXCL1, CCL2, IL-6, TNF-alpha, and TGF-beta1 in the implants but did not alter the levels of IL-10. sethoxydim 0-4 interleukin 6 Mus musculus 105-109 32125592-7 2020 NaBu treatment was also able to decrease mast cell recruitment/activation and the levels of CXCL1, CCL2, IL-6, TNF-alpha, and TGF-beta1 in the implants but did not alter the levels of IL-10. sethoxydim 0-4 tumor necrosis factor Mus musculus 111-120 32125592-7 2020 NaBu treatment was also able to decrease mast cell recruitment/activation and the levels of CXCL1, CCL2, IL-6, TNF-alpha, and TGF-beta1 in the implants but did not alter the levels of IL-10. sethoxydim 0-4 transforming growth factor, beta 1 Mus musculus 126-135 32125592-8 2020 In addition, NaBu administration decreased the concentration of proteins p65 and p50 in the nucleus as compared with the cytoplasm by western blot analysis. sethoxydim 13-17 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 73-76 32125592-8 2020 In addition, NaBu administration decreased the concentration of proteins p65 and p50 in the nucleus as compared with the cytoplasm by western blot analysis. sethoxydim 13-17 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 81-84 32125592-10 2020 The circulating levels of TNF-alpha and TGF-beta1 were also attenuated by NaBu. sethoxydim 74-78 tumor necrosis factor Mus musculus 26-35 32125592-10 2020 The circulating levels of TNF-alpha and TGF-beta1 were also attenuated by NaBu. sethoxydim 74-78 transforming growth factor, beta 1 Mus musculus 40-49 33274003-8 2020 Mechanistically, we found an enhanced TXNIP expression in response to NaBu treatment in all the three models. sethoxydim 70-74 thioredoxin interacting protein Mus musculus 38-43 33274003-9 2020 Overexpressing TXNIP in HUVEC cells blocked its tube formation and inhibited its proliferation; on the other hand, knocking down its expression with shRNA reversed those phenotypes in context of NaBu treatment. sethoxydim 195-199 thioredoxin interacting protein Mus musculus 15-20 33274003-10 2020 Further investigation showed the expression of VEGF receptor 2 (VEGFR2) in HUVEC cells was regulated by TXNIP undergoing NaBu treatment. sethoxydim 121-125 kinase insert domain protein receptor Mus musculus 47-62 33274003-10 2020 Further investigation showed the expression of VEGF receptor 2 (VEGFR2) in HUVEC cells was regulated by TXNIP undergoing NaBu treatment. sethoxydim 121-125 kinase insert domain protein receptor Mus musculus 64-70 33274003-10 2020 Further investigation showed the expression of VEGF receptor 2 (VEGFR2) in HUVEC cells was regulated by TXNIP undergoing NaBu treatment. sethoxydim 121-125 thioredoxin interacting protein Mus musculus 104-109 33274003-11 2020 We therefore argued that NaBu inhibited neovascularization partially through TXNIP-regulated VEGFR2 signal pathway. sethoxydim 25-29 thioredoxin interacting protein Mus musculus 77-82 33274003-11 2020 We therefore argued that NaBu inhibited neovascularization partially through TXNIP-regulated VEGFR2 signal pathway. sethoxydim 25-29 kinase insert domain protein receptor Mus musculus 93-99 31565858-2 2019 The present work is aimed to investigate the effect of NaBu on angiotensin II (Ang II)-induced cardiac hypertrophy and the underlying mechanism in in vivo and in vitro models. sethoxydim 55-59 angiotensinogen Rattus norvegicus 79-85 31565858-5 2019 The cardiomyocytes H9C2 cells were used as in vitro model to investigate the role of NaBu (2 mmol/L) in inhibition of Ang II-induced cardiac hypertrophy. sethoxydim 85-89 angiotensinogen Rattus norvegicus 118-124 31565858-6 2019 NaBu significantly attenuated Ang II-induced increase in the mean arterial pressure. sethoxydim 0-4 angiotensinogen Rattus norvegicus 30-36 31565858-7 2019 Ang II treatment remarkably increased cardiac hypertrophy as indicated by increased ratio of heart weight/body weight and enlarged cardiomyocyte size, extensive fibrosis and inflammation, as well as enhanced expression of hypertrophic markers, whereas hearts from NaBu-treated rats exhibited a significant reduction in these hypertrophic responses. sethoxydim 264-268 angiotensinogen Rattus norvegicus 0-6 31565858-8 2019 Mechanistically, NaBu inhibited the expression of COX2/PGE2 along with production of ANP and phosphorylated ERK (pERK) stimulated by Ang II in in vivo and in vitro, which was accompanied by the suppression of HDAC5 and HDAC6 activities. sethoxydim 17-21 cytochrome c oxidase II, mitochondrial Rattus norvegicus 50-54 31565858-8 2019 Mechanistically, NaBu inhibited the expression of COX2/PGE2 along with production of ANP and phosphorylated ERK (pERK) stimulated by Ang II in in vivo and in vitro, which was accompanied by the suppression of HDAC5 and HDAC6 activities. sethoxydim 17-21 natriuretic peptide A Rattus norvegicus 85-88 31565858-8 2019 Mechanistically, NaBu inhibited the expression of COX2/PGE2 along with production of ANP and phosphorylated ERK (pERK) stimulated by Ang II in in vivo and in vitro, which was accompanied by the suppression of HDAC5 and HDAC6 activities. sethoxydim 17-21 Eph receptor B1 Rattus norvegicus 108-111 31565858-8 2019 Mechanistically, NaBu inhibited the expression of COX2/PGE2 along with production of ANP and phosphorylated ERK (pERK) stimulated by Ang II in in vivo and in vitro, which was accompanied by the suppression of HDAC5 and HDAC6 activities. sethoxydim 17-21 angiotensinogen Rattus norvegicus 133-139 31565858-8 2019 Mechanistically, NaBu inhibited the expression of COX2/PGE2 along with production of ANP and phosphorylated ERK (pERK) stimulated by Ang II in in vivo and in vitro, which was accompanied by the suppression of HDAC5 and HDAC6 activities. sethoxydim 17-21 histone deacetylase 5 Rattus norvegicus 209-214 31565858-8 2019 Mechanistically, NaBu inhibited the expression of COX2/PGE2 along with production of ANP and phosphorylated ERK (pERK) stimulated by Ang II in in vivo and in vitro, which was accompanied by the suppression of HDAC5 and HDAC6 activities. sethoxydim 17-21 histone deacetylase 6 Rattus norvegicus 219-224 31565858-10 2019 These results provide solid evidence that NaBu attenuates Ang II-induced cardiac hypertrophy by inhibiting the activation of COX2/PGE2 pathway in a HDAC5/HDAC6-dependent manner. sethoxydim 42-46 angiotensinogen Rattus norvegicus 58-64 31565858-10 2019 These results provide solid evidence that NaBu attenuates Ang II-induced cardiac hypertrophy by inhibiting the activation of COX2/PGE2 pathway in a HDAC5/HDAC6-dependent manner. sethoxydim 42-46 cytochrome c oxidase II, mitochondrial Rattus norvegicus 125-129 31565858-10 2019 These results provide solid evidence that NaBu attenuates Ang II-induced cardiac hypertrophy by inhibiting the activation of COX2/PGE2 pathway in a HDAC5/HDAC6-dependent manner. sethoxydim 42-46 histone deacetylase 5 Rattus norvegicus 148-153 31565858-10 2019 These results provide solid evidence that NaBu attenuates Ang II-induced cardiac hypertrophy by inhibiting the activation of COX2/PGE2 pathway in a HDAC5/HDAC6-dependent manner. sethoxydim 42-46 histone deacetylase 6 Rattus norvegicus 154-159 31226809-3 2019 NaBu, at 1 mM, optimally promoted endodermal differentiation of hWJ-MSCs, along with epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) supplementation (EGF + bFGF + 1 mM NaBu). sethoxydim 0-4 epidermal growth factor Homo sapiens 174-177 31023529-9 2019 Increased LC3 dots and LC3-II accumulation indicated that NaBu can promote autophagy flux in NPC cells. sethoxydim 58-62 microtubule associated protein 1 light chain 3 alpha Homo sapiens 10-13 31023529-9 2019 Increased LC3 dots and LC3-II accumulation indicated that NaBu can promote autophagy flux in NPC cells. sethoxydim 58-62 microtubule associated protein 1 light chain 3 alpha Homo sapiens 23-26 31023529-11 2019 Moreover, autophagy inhibition, achieved by 3-MA treatment or BECN1 knockdown, can antagonize NaBu induced apoptosis reflecting by re-deregulated cPARP and apoptotic rates. sethoxydim 94-98 beclin 1 Homo sapiens 62-67 31023529-12 2019 Furthermore, NaBu treatment inhibited the AKT/mTOR axis indicated by deregulated p-AKT(S473) and p-mTOR(S2448) and ectopic AKT expression both suppressed NaBu induced autophagy and apoptosis. sethoxydim 13-17 AKT serine/threonine kinase 1 Homo sapiens 42-45 31023529-12 2019 Furthermore, NaBu treatment inhibited the AKT/mTOR axis indicated by deregulated p-AKT(S473) and p-mTOR(S2448) and ectopic AKT expression both suppressed NaBu induced autophagy and apoptosis. sethoxydim 13-17 mechanistic target of rapamycin kinase Homo sapiens 46-50 31356635-5 2019 However, the ratio of phosphor-extracellular signal-regulated kinases (p-ERK)/ERK significantly decreased in oocytes treated with 2.0 mM NaBu for 8 h. Furthermore, NaBu treatment at 2.0 mM improved the quality of embryos and the mRNA expression levels of important developmental genes such as HDAC1, Sox2, and Pou5f1. sethoxydim 137-141 mitogen-activated protein kinase 1 Homo sapiens 73-76 31356635-5 2019 However, the ratio of phosphor-extracellular signal-regulated kinases (p-ERK)/ERK significantly decreased in oocytes treated with 2.0 mM NaBu for 8 h. Furthermore, NaBu treatment at 2.0 mM improved the quality of embryos and the mRNA expression levels of important developmental genes such as HDAC1, Sox2, and Pou5f1. sethoxydim 137-141 mitogen-activated protein kinase 1 Homo sapiens 78-81 31356635-5 2019 However, the ratio of phosphor-extracellular signal-regulated kinases (p-ERK)/ERK significantly decreased in oocytes treated with 2.0 mM NaBu for 8 h. Furthermore, NaBu treatment at 2.0 mM improved the quality of embryos and the mRNA expression levels of important developmental genes such as HDAC1, Sox2, and Pou5f1. sethoxydim 137-141 histone deacetylase 1 Homo sapiens 293-298 31356635-5 2019 However, the ratio of phosphor-extracellular signal-regulated kinases (p-ERK)/ERK significantly decreased in oocytes treated with 2.0 mM NaBu for 8 h. Furthermore, NaBu treatment at 2.0 mM improved the quality of embryos and the mRNA expression levels of important developmental genes such as HDAC1, Sox2, and Pou5f1. sethoxydim 137-141 SRY-box transcription factor 2 Homo sapiens 300-304 31356635-5 2019 However, the ratio of phosphor-extracellular signal-regulated kinases (p-ERK)/ERK significantly decreased in oocytes treated with 2.0 mM NaBu for 8 h. Furthermore, NaBu treatment at 2.0 mM improved the quality of embryos and the mRNA expression levels of important developmental genes such as HDAC1, Sox2, and Pou5f1. sethoxydim 137-141 POU class 5 homeobox 1 Homo sapiens 310-316 31356635-5 2019 However, the ratio of phosphor-extracellular signal-regulated kinases (p-ERK)/ERK significantly decreased in oocytes treated with 2.0 mM NaBu for 8 h. Furthermore, NaBu treatment at 2.0 mM improved the quality of embryos and the mRNA expression levels of important developmental genes such as HDAC1, Sox2, and Pou5f1. sethoxydim 164-168 mitogen-activated protein kinase 1 Homo sapiens 73-76 31356635-5 2019 However, the ratio of phosphor-extracellular signal-regulated kinases (p-ERK)/ERK significantly decreased in oocytes treated with 2.0 mM NaBu for 8 h. Furthermore, NaBu treatment at 2.0 mM improved the quality of embryos and the mRNA expression levels of important developmental genes such as HDAC1, Sox2, and Pou5f1. sethoxydim 164-168 mitogen-activated protein kinase 1 Homo sapiens 78-81 31356635-5 2019 However, the ratio of phosphor-extracellular signal-regulated kinases (p-ERK)/ERK significantly decreased in oocytes treated with 2.0 mM NaBu for 8 h. Furthermore, NaBu treatment at 2.0 mM improved the quality of embryos and the mRNA expression levels of important developmental genes such as HDAC1, Sox2, and Pou5f1. sethoxydim 164-168 histone deacetylase 1 Homo sapiens 293-298 31356635-5 2019 However, the ratio of phosphor-extracellular signal-regulated kinases (p-ERK)/ERK significantly decreased in oocytes treated with 2.0 mM NaBu for 8 h. Furthermore, NaBu treatment at 2.0 mM improved the quality of embryos and the mRNA expression levels of important developmental genes such as HDAC1, Sox2, and Pou5f1. sethoxydim 164-168 SRY-box transcription factor 2 Homo sapiens 300-304 31356635-5 2019 However, the ratio of phosphor-extracellular signal-regulated kinases (p-ERK)/ERK significantly decreased in oocytes treated with 2.0 mM NaBu for 8 h. Furthermore, NaBu treatment at 2.0 mM improved the quality of embryos and the mRNA expression levels of important developmental genes such as HDAC1, Sox2, and Pou5f1. sethoxydim 164-168 POU class 5 homeobox 1 Homo sapiens 310-316 31226809-5 2019 Immunocytochemistry and a Western blot analysis of SOX17 and HNF3beta confirmed that the EGF + bFGF + 1 mM NaBu condition was appropriately pre-treated with hWJ-MSCs before hepatogenic differentiation. sethoxydim 107-111 epidermal growth factor Homo sapiens 89-92 31226809-6 2019 Furthermore, the hepatogenic medium + NaBu pre-treatment up-regulated hepatoblast (AFP and HNF3beta) and hepatic (CK18 and ALB) markers, and increased the proportion of mature hepatocyte functions, including G6P, C/EBPalpha, and CYP2B6 mRNAs, glycogen storage and urea secretion. sethoxydim 38-42 alpha fetoprotein Homo sapiens 83-86 31226809-6 2019 Furthermore, the hepatogenic medium + NaBu pre-treatment up-regulated hepatoblast (AFP and HNF3beta) and hepatic (CK18 and ALB) markers, and increased the proportion of mature hepatocyte functions, including G6P, C/EBPalpha, and CYP2B6 mRNAs, glycogen storage and urea secretion. sethoxydim 38-42 forkhead box A2 Homo sapiens 91-99 31226809-6 2019 Furthermore, the hepatogenic medium + NaBu pre-treatment up-regulated hepatoblast (AFP and HNF3beta) and hepatic (CK18 and ALB) markers, and increased the proportion of mature hepatocyte functions, including G6P, C/EBPalpha, and CYP2B6 mRNAs, glycogen storage and urea secretion. sethoxydim 38-42 keratin 18 Homo sapiens 114-118 31226809-6 2019 Furthermore, the hepatogenic medium + NaBu pre-treatment up-regulated hepatoblast (AFP and HNF3beta) and hepatic (CK18 and ALB) markers, and increased the proportion of mature hepatocyte functions, including G6P, C/EBPalpha, and CYP2B6 mRNAs, glycogen storage and urea secretion. sethoxydim 38-42 CCAAT enhancer binding protein alpha Homo sapiens 213-223 31226809-6 2019 Furthermore, the hepatogenic medium + NaBu pre-treatment up-regulated hepatoblast (AFP and HNF3beta) and hepatic (CK18 and ALB) markers, and increased the proportion of mature hepatocyte functions, including G6P, C/EBPalpha, and CYP2B6 mRNAs, glycogen storage and urea secretion. sethoxydim 38-42 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 229-235 31023529-12 2019 Furthermore, NaBu treatment inhibited the AKT/mTOR axis indicated by deregulated p-AKT(S473) and p-mTOR(S2448) and ectopic AKT expression both suppressed NaBu induced autophagy and apoptosis. sethoxydim 13-17 AKT serine/threonine kinase 1 Homo sapiens 83-86 31023529-12 2019 Furthermore, NaBu treatment inhibited the AKT/mTOR axis indicated by deregulated p-AKT(S473) and p-mTOR(S2448) and ectopic AKT expression both suppressed NaBu induced autophagy and apoptosis. sethoxydim 13-17 mechanistic target of rapamycin kinase Homo sapiens 99-103 31023529-12 2019 Furthermore, NaBu treatment inhibited the AKT/mTOR axis indicated by deregulated p-AKT(S473) and p-mTOR(S2448) and ectopic AKT expression both suppressed NaBu induced autophagy and apoptosis. sethoxydim 13-17 AKT serine/threonine kinase 1 Homo sapiens 83-86 31023529-12 2019 Furthermore, NaBu treatment inhibited the AKT/mTOR axis indicated by deregulated p-AKT(S473) and p-mTOR(S2448) and ectopic AKT expression both suppressed NaBu induced autophagy and apoptosis. sethoxydim 154-158 AKT serine/threonine kinase 1 Homo sapiens 42-45 31023529-12 2019 Furthermore, NaBu treatment inhibited the AKT/mTOR axis indicated by deregulated p-AKT(S473) and p-mTOR(S2448) and ectopic AKT expression both suppressed NaBu induced autophagy and apoptosis. sethoxydim 154-158 mechanistic target of rapamycin kinase Homo sapiens 46-50 31023529-12 2019 Furthermore, NaBu treatment inhibited the AKT/mTOR axis indicated by deregulated p-AKT(S473) and p-mTOR(S2448) and ectopic AKT expression both suppressed NaBu induced autophagy and apoptosis. sethoxydim 154-158 mechanistic target of rapamycin kinase Homo sapiens 99-103 31023529-13 2019 At last, Western blot showed that HDAC6 dependent EGFR deregulation may account for the NaBu associated AKT/mTOR inhibition. sethoxydim 88-92 histone deacetylase 6 Homo sapiens 34-39 31023529-13 2019 At last, Western blot showed that HDAC6 dependent EGFR deregulation may account for the NaBu associated AKT/mTOR inhibition. sethoxydim 88-92 epidermal growth factor receptor Homo sapiens 50-54 31023529-13 2019 At last, Western blot showed that HDAC6 dependent EGFR deregulation may account for the NaBu associated AKT/mTOR inhibition. sethoxydim 88-92 AKT serine/threonine kinase 1 Homo sapiens 104-107 31023529-13 2019 At last, Western blot showed that HDAC6 dependent EGFR deregulation may account for the NaBu associated AKT/mTOR inhibition. sethoxydim 88-92 mechanistic target of rapamycin kinase Homo sapiens 108-112 31023529-14 2019 NaBu can induce autophagic apoptosis via suppressing AKT/mTOR axis in NPC cells. sethoxydim 0-4 AKT serine/threonine kinase 1 Homo sapiens 53-56 31023529-14 2019 NaBu can induce autophagic apoptosis via suppressing AKT/mTOR axis in NPC cells. sethoxydim 0-4 mechanistic target of rapamycin kinase Homo sapiens 57-61 31226809-3 2019 NaBu, at 1 mM, optimally promoted endodermal differentiation of hWJ-MSCs, along with epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) supplementation (EGF + bFGF + 1 mM NaBu). sethoxydim 0-4 fibroblast growth factor 2 Homo sapiens 180-184 30653577-10 2019 We found that NaBu dramatically induce expression of E-cadherin gene (CDH1) and protein levels in A2780 and A2780cis. sethoxydim 14-18 cadherin 1 Homo sapiens 53-63 30221828-8 2019 In summary, these results demonstrate 1,3,4-O-Bu3 ManNAc can compensate for the negative effect of NaBu on EPO glycan quality while simultaneously enhancing recombinant protein yields. sethoxydim 99-103 erythropoietin Cricetulus griseus 107-110 30221828-2 2019 In this study, butyrate supplied by the precursor molecule 1,3,4-O-Bu3 ManNAc is applied to overcome the negative effects of NaBu on glycan quality while simultaneously increasing the productivity of the model recombinant erythropoietin (EPO). sethoxydim 125-129 erythropoietin Cricetulus griseus 222-236 30221828-7 2019 Moreover, a detailed mass spectrometric ESI-LC-MS/MS characterization of glycans at each of the three N-glycosylation sites of EPO showed that the 1st N-site is highly sialylated and either the negative impact of NaBu or the beneficial effect 1,3,4-O-Bu3 ManNAc treatments mainly affects the 2nd and 3rd N-glycan sites of EPO protein. sethoxydim 213-217 erythropoietin Cricetulus griseus 127-130 30653577-10 2019 We found that NaBu dramatically induce expression of E-cadherin gene (CDH1) and protein levels in A2780 and A2780cis. sethoxydim 14-18 cadherin 1 Homo sapiens 70-74 30653577-15 2019 However, NaBu-induced expression of CDH1 was not accompanied by CDH1 demethylation. sethoxydim 9-13 cadherin 1 Homo sapiens 36-40 30653577-16 2019 NaBu treatment induced changes in expression of EMT-related genes and proteins. sethoxydim 0-4 IL2 inducible T cell kinase Homo sapiens 48-51 30653577-20 2019 NaBu induced mRNA expression of MMPs, mild changes in activities of gelatinases MMP2 and MMP9 were detected. sethoxydim 0-4 matrix metallopeptidase 2 Homo sapiens 32-36 30653577-20 2019 NaBu induced mRNA expression of MMPs, mild changes in activities of gelatinases MMP2 and MMP9 were detected. sethoxydim 0-4 matrix metallopeptidase 2 Homo sapiens 80-84 30653577-20 2019 NaBu induced mRNA expression of MMPs, mild changes in activities of gelatinases MMP2 and MMP9 were detected. sethoxydim 0-4 matrix metallopeptidase 9 Homo sapiens 89-93 30653577-21 2019 Our data demonstrate that NaBu sensitizes cisplatin-resistant ovarian cancer cells, re-established E-cadherin expression, but it was not able to reverse the EMT phenotype completely. sethoxydim 26-30 cadherin 1 Homo sapiens 99-109 30318011-10 2019 CONCLUSION: The combination treatment of p53-null HL-60 cells with DNA-damaging agent CLB and HDACIs NaBu and TSA triggered additive to synergistic effects on apoptosis and upregulated BCL6 and p21 expression. sethoxydim 101-105 tumor protein p53 Homo sapiens 41-44 30318011-10 2019 CONCLUSION: The combination treatment of p53-null HL-60 cells with DNA-damaging agent CLB and HDACIs NaBu and TSA triggered additive to synergistic effects on apoptosis and upregulated BCL6 and p21 expression. sethoxydim 101-105 BCL6 transcription repressor Homo sapiens 185-189 30318011-10 2019 CONCLUSION: The combination treatment of p53-null HL-60 cells with DNA-damaging agent CLB and HDACIs NaBu and TSA triggered additive to synergistic effects on apoptosis and upregulated BCL6 and p21 expression. sethoxydim 101-105 H3 histone pseudogene 16 Homo sapiens 194-197 28566502-4 2017 The objective of the present study was to determine the physiological efficacy and impact of all-trans-retinoic acid (ATRA) and sodium butyrate (NaBu) in ameliorating the renal fibrosis, inflammation, and hypertension in Npr1 gene-disrupted haplotype (1-copy; +/-) mice (50% expression levels of NPRA). sethoxydim 145-149 natriuretic peptide receptor 1 Mus musculus 221-225 29475458-9 2018 Cell viability after MTX treatment with LV rescue was evaluated using sodium butyrate (NaBu), a histone-deacetylase inhibitor that induces polyglutamylation by elevating FPGS expression. sethoxydim 87-91 folylpolyglutamate synthase Homo sapiens 170-174 29475458-11 2018 In vitro, the relief effect of LV after MTX administration was significantly enhanced after FPGS knockdown in al cell lines, whereas enhancement of FPGS expression by NaBu treatment significantly reduced this relief effect. sethoxydim 167-171 folylpolyglutamate synthase Homo sapiens 148-152 30616788-4 2019 RESULTS: In this study, we found that NaBu inhibited growth and induced apoptosis in the human oral MEC cell lines MC3 and YD15 with acetylation of histone proteins H2A and H3. sethoxydim 38-42 H2A clustered histone 18 Homo sapiens 165-175 30616788-7 2019 NaBu also resulted in decreased expression levels of Bcl-xL mRNA and protein, leading to induction of caspase-dependent apoptosis in human oral MEC cell lines. sethoxydim 0-4 BCL2 like 1 Homo sapiens 53-59 29271554-6 2018 When NaBu was supplemented at a concentration of <1.0 mM for 3 days during osteogenic induction, significantly more mineralized nodules were generated and the expression of osteogenesis-related genes (ALP, Runx2, Opn, and Ocn) and proteins (Col1a1, OPN, OCN, Runx2, and TAZ) were both significantly enhanced. sethoxydim 5-9 ATHS Homo sapiens 204-207 29271554-6 2018 When NaBu was supplemented at a concentration of <1.0 mM for 3 days during osteogenic induction, significantly more mineralized nodules were generated and the expression of osteogenesis-related genes (ALP, Runx2, Opn, and Ocn) and proteins (Col1a1, OPN, OCN, Runx2, and TAZ) were both significantly enhanced. sethoxydim 5-9 RUNX family transcription factor 2 Homo sapiens 209-214 29271554-6 2018 When NaBu was supplemented at a concentration of <1.0 mM for 3 days during osteogenic induction, significantly more mineralized nodules were generated and the expression of osteogenesis-related genes (ALP, Runx2, Opn, and Ocn) and proteins (Col1a1, OPN, OCN, Runx2, and TAZ) were both significantly enhanced. sethoxydim 5-9 secreted phosphoprotein 1 Homo sapiens 216-219 29271554-6 2018 When NaBu was supplemented at a concentration of <1.0 mM for 3 days during osteogenic induction, significantly more mineralized nodules were generated and the expression of osteogenesis-related genes (ALP, Runx2, Opn, and Ocn) and proteins (Col1a1, OPN, OCN, Runx2, and TAZ) were both significantly enhanced. sethoxydim 5-9 bone gamma-carboxyglutamate protein Homo sapiens 225-228 29271554-6 2018 When NaBu was supplemented at a concentration of <1.0 mM for 3 days during osteogenic induction, significantly more mineralized nodules were generated and the expression of osteogenesis-related genes (ALP, Runx2, Opn, and Ocn) and proteins (Col1a1, OPN, OCN, Runx2, and TAZ) were both significantly enhanced. sethoxydim 5-9 collagen type I alpha 1 chain Homo sapiens 244-250 29271554-6 2018 When NaBu was supplemented at a concentration of <1.0 mM for 3 days during osteogenic induction, significantly more mineralized nodules were generated and the expression of osteogenesis-related genes (ALP, Runx2, Opn, and Ocn) and proteins (Col1a1, OPN, OCN, Runx2, and TAZ) were both significantly enhanced. sethoxydim 5-9 secreted phosphoprotein 1 Homo sapiens 252-255 29271554-6 2018 When NaBu was supplemented at a concentration of <1.0 mM for 3 days during osteogenic induction, significantly more mineralized nodules were generated and the expression of osteogenesis-related genes (ALP, Runx2, Opn, and Ocn) and proteins (Col1a1, OPN, OCN, Runx2, and TAZ) were both significantly enhanced. sethoxydim 5-9 bone gamma-carboxyglutamate protein Homo sapiens 257-260 29271554-6 2018 When NaBu was supplemented at a concentration of <1.0 mM for 3 days during osteogenic induction, significantly more mineralized nodules were generated and the expression of osteogenesis-related genes (ALP, Runx2, Opn, and Ocn) and proteins (Col1a1, OPN, OCN, Runx2, and TAZ) were both significantly enhanced. sethoxydim 5-9 RUNX family transcription factor 2 Homo sapiens 262-267 29271554-6 2018 When NaBu was supplemented at a concentration of <1.0 mM for 3 days during osteogenic induction, significantly more mineralized nodules were generated and the expression of osteogenesis-related genes (ALP, Runx2, Opn, and Ocn) and proteins (Col1a1, OPN, OCN, Runx2, and TAZ) were both significantly enhanced. sethoxydim 5-9 tafazzin, phospholipid-lysophospholipid transacylase Homo sapiens 273-276 29271554-7 2018 However, a higher concentration (1.0 mM) and longer exposure time (14 days) of NaBu showed no such effects, which may be partially attributed to both the increased expression of histone deacetylase 8 (HDAC8) and reduced level of H3K9-Ace, thus leading to the transcriptional inhibition during osteogenesis. sethoxydim 79-83 histone deacetylase 8 Homo sapiens 178-199 29271554-7 2018 However, a higher concentration (1.0 mM) and longer exposure time (14 days) of NaBu showed no such effects, which may be partially attributed to both the increased expression of histone deacetylase 8 (HDAC8) and reduced level of H3K9-Ace, thus leading to the transcriptional inhibition during osteogenesis. sethoxydim 79-83 histone deacetylase 8 Homo sapiens 201-206 29271554-8 2018 Further, it was indicated that ERK might be involved in the stimulatory effects of NaBu. sethoxydim 83-87 mitogen-activated protein kinase 1 Homo sapiens 31-34 28566502-4 2017 The objective of the present study was to determine the physiological efficacy and impact of all-trans-retinoic acid (ATRA) and sodium butyrate (NaBu) in ameliorating the renal fibrosis, inflammation, and hypertension in Npr1 gene-disrupted haplotype (1-copy; +/-) mice (50% expression levels of NPRA). sethoxydim 145-149 natriuretic peptide receptor 1 Mus musculus 296-300 28566502-5 2017 Both ATRA and NaBu, either alone or in combination, decreased the elevated levels of renal proinflammatory and profibrotic cytokines and lowered blood pressure in Npr1+/- mice compared with untreated controls. sethoxydim 14-18 natriuretic peptide receptor 1 Mus musculus 163-167 28509726-4 2017 The present study was aimed to investigate the role of NaBu in angiotensin II (Ang II)-induced hypertension and to further explore the underlying mechanism. sethoxydim 55-59 angiotensinogen Rattus norvegicus 63-77 28509726-4 2017 The present study was aimed to investigate the role of NaBu in angiotensin II (Ang II)-induced hypertension and to further explore the underlying mechanism. sethoxydim 55-59 angiotensinogen Rattus norvegicus 79-85 28509726-8 2017 RESULTS: Intramedullary infusion of NaBu in Sprague-Dawley rats lowered the Ang II-induced mean arterial pressure from 129 +- 6 mmHg to 108 +- 4 mmHg (P < 0.01). sethoxydim 36-40 angiotensinogen Rattus norvegicus 76-82 28509726-10 2017 The renal expression of PRR, angiotensinogen, angiotensin I-converting enzyme and the urinary excretion of soluble PRR, renin, and angiotensinogen were all increased by Ang II infusion but decreased by NaBu treatment. sethoxydim 202-206 angiotensin I converting enzyme Rattus norvegicus 46-77 28509726-10 2017 The renal expression of PRR, angiotensinogen, angiotensin I-converting enzyme and the urinary excretion of soluble PRR, renin, and angiotensinogen were all increased by Ang II infusion but decreased by NaBu treatment. sethoxydim 202-206 angiotensinogen Rattus norvegicus 131-146 28509726-11 2017 In cultured innermedullary collecting duct cells, NaBu treatment attenuated Ang II-induced expression of PRR and renin. sethoxydim 50-54 angiotensinogen Rattus norvegicus 76-82 28033672-8 2017 TXNIP was strongly induced by NaBu (30- to 40-fold mRNA) but was only slightly induced by 4PBA (two to fivefold) in A549 cells. sethoxydim 30-34 thioredoxin interacting protein Homo sapiens 0-5 28509726-11 2017 In cultured innermedullary collecting duct cells, NaBu treatment attenuated Ang II-induced expression of PRR and renin. sethoxydim 50-54 renin Rattus norvegicus 113-118 28509726-12 2017 CONCLUSION: These results demonstrate that NaBu exerts an antihypertensive action, likely by suppressing the PRR-mediated intrarenal renin-angiotensin system. sethoxydim 43-47 renin Rattus norvegicus 133-138 28033672-10 2017 Moreover, TXNIP also regulated NaBu- but not 4PBA-induced H4K5 acetylation and H3K4 trimethylation, possibly by increasing WDR5 expression. sethoxydim 31-35 thioredoxin interacting protein Homo sapiens 10-15 28033672-11 2017 Finally, we demonstrated that 4PBA induced a mitochondrial superoxide-associated cell death, while NaBu did so mainly through a TXNIP-mediated pathway. sethoxydim 99-103 thioredoxin interacting protein Homo sapiens 128-133 28356979-8 2017 Inhibition of SOCE by specific inhibitors or downregulated expression of calcium release-activated calcium channel protein 1 and stromal interaction molecule 1 could counteract the apoptosis of NPC cells induced by NaBu. sethoxydim 215-219 ORAI calcium release-activated calcium modulator 1 Homo sapiens 73-124 28356979-8 2017 Inhibition of SOCE by specific inhibitors or downregulated expression of calcium release-activated calcium channel protein 1 and stromal interaction molecule 1 could counteract the apoptosis of NPC cells induced by NaBu. sethoxydim 215-219 stromal interaction molecule 1 Homo sapiens 129-159 28600747-1 2016 Sodium butyrate (NaBu) is a by-product of microbial fermentation of dietary fiber in the gastrointestinal tract and has been shown to increase the activity of antioxidant enzymes, such as catalase or heme oxidase-1, in vivo. sethoxydim 17-21 catalase Homo sapiens 188-196 27813594-6 2016 We found that EO, NaBu, and exogenous IAP were able to up-regulate endogenous IAP and enhance RelA/p65 (NF-kappaB) gene expression. sethoxydim 18-22 alkaline phosphatase, intestinal Homo sapiens 78-81 27813594-6 2016 We found that EO, NaBu, and exogenous IAP were able to up-regulate endogenous IAP and enhance RelA/p65 (NF-kappaB) gene expression. sethoxydim 18-22 RELA proto-oncogene, NF-kB subunit Homo sapiens 94-98 27813594-6 2016 We found that EO, NaBu, and exogenous IAP were able to up-regulate endogenous IAP and enhance RelA/p65 (NF-kappaB) gene expression. sethoxydim 18-22 RELA proto-oncogene, NF-kB subunit Homo sapiens 99-102 27813594-6 2016 We found that EO, NaBu, and exogenous IAP were able to up-regulate endogenous IAP and enhance RelA/p65 (NF-kappaB) gene expression. sethoxydim 18-22 nuclear factor kappa B subunit 1 Homo sapiens 104-113 27813594-7 2016 However, only NaBu and exogenous IAP down-regulated LPS-induced inflammatory response via RelA/p65 (NF-kappaB). sethoxydim 14-18 RELA proto-oncogene, NF-kB subunit Homo sapiens 90-94 27813594-7 2016 However, only NaBu and exogenous IAP down-regulated LPS-induced inflammatory response via RelA/p65 (NF-kappaB). sethoxydim 14-18 RELA proto-oncogene, NF-kB subunit Homo sapiens 95-98 27813594-7 2016 However, only NaBu and exogenous IAP down-regulated LPS-induced inflammatory response via RelA/p65 (NF-kappaB). sethoxydim 14-18 nuclear factor kappa B subunit 1 Homo sapiens 100-109 27365379-10 2016 Also, in MDA-MB 231 treated with DZNEP, H3K27me3 significantly decreased on SRC3 while H3K4ac was significantly increased in MDA-MB-231 treated with SAHA or NaBu for P300. sethoxydim 157-161 E1A binding protein p300 Homo sapiens 166-170 27813594-2 2016 Intestinal alkaline phosphatase and RelA/p65 (NF-kappaB) gene expressions in porcine jejunum explants were evaluated following exposure to sodium butyrate (NaBu) and essential oil from Brazilian red pepper (EO), alone or in combination with NaBu, as well as exogenous IAP with or without LPS challenge. sethoxydim 156-160 nuclear factor kappa B subunit 1 Homo sapiens 46-55 27694930-4 2016 Furthermore, cell exposure to low NaBu concentrations increased expression of proteins involved in angiogenic cell signalling, including p-PKCbeta1, p-FAK, p-ERK1/2, p-NFkappabeta, p-PLCgamma1 and p-VEGFR2. sethoxydim 34-38 phospholipase C, gamma 1 Mus musculus 183-192 27694930-4 2016 Furthermore, cell exposure to low NaBu concentrations increased expression of proteins involved in angiogenic cell signalling, including p-PKCbeta1, p-FAK, p-ERK1/2, p-NFkappabeta, p-PLCgamma1 and p-VEGFR2. sethoxydim 34-38 kinase insert domain protein receptor Mus musculus 199-205 28600747-5 2016 NaBu inhibited glycogen synthase kinase-3 beta (GSK-3beta) by increasing the p-GSK-3beta (Ser9) level and promoted nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2), which increased the expression of downstream antioxidant enzymes. sethoxydim 0-4 glycogen synthase kinase 3 beta Homo sapiens 48-57 28600747-5 2016 NaBu inhibited glycogen synthase kinase-3 beta (GSK-3beta) by increasing the p-GSK-3beta (Ser9) level and promoted nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2), which increased the expression of downstream antioxidant enzymes. sethoxydim 0-4 glycogen synthase kinase 3 beta Homo sapiens 79-88 28600747-5 2016 NaBu inhibited glycogen synthase kinase-3 beta (GSK-3beta) by increasing the p-GSK-3beta (Ser9) level and promoted nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2), which increased the expression of downstream antioxidant enzymes. sethoxydim 0-4 NFE2 like bZIP transcription factor 2 Homo sapiens 140-183 28600747-5 2016 NaBu inhibited glycogen synthase kinase-3 beta (GSK-3beta) by increasing the p-GSK-3beta (Ser9) level and promoted nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2), which increased the expression of downstream antioxidant enzymes. sethoxydim 0-4 NFE2 like bZIP transcription factor 2 Homo sapiens 185-189 28600747-6 2016 Together with promotion of peroxisome proliferator-activated receptor gamma coactivator 1-alpha and mitochondrial DNA copy number, NaBu modulated energy metabolism and mitochondrial function, decreasing glycolysis, increasing beta-oxidation, and enhancing the tricarboxylic acid cycle and oxidative phosphorylation. sethoxydim 131-135 PPARG coactivator 1 alpha Homo sapiens 27-95 28600747-7 2016 NaBu increased mitochondrial manganese-superoxide dismutase and glutathione peroxidase activity. sethoxydim 0-4 superoxide dismutase 2 Homo sapiens 29-59 28600747-8 2016 In conclusion, NaBu protected HepG2 cells against oxidative stress by modulating Nrf2 pathway activity and mitochondrial function. sethoxydim 15-19 NFE2 like bZIP transcription factor 2 Homo sapiens 81-85 27019068-7 2016 We also determined the effect of the histone deacetylase inhibitor sodium butyrate (NaBu) on AKR1C3 expression in EPG 85-257 and HGC-27 GC cell lines. sethoxydim 84-88 aldo-keto reductase family 1 member C3 Homo sapiens 93-99 27019068-8 2016 We found that NaBu elevates the levels of both AKR1C3 transcript and protein in the cell lines we investigated. sethoxydim 14-18 aldo-keto reductase family 1 member C3 Homo sapiens 47-53 27019068-9 2016 Together, our results suggest that decreased expression of AKR1C3 may be involved in development of GC and can be restored by NaBu. sethoxydim 126-130 aldo-keto reductase family 1 member C3 Homo sapiens 59-65 26555753-8 2015 Thus, we confirm that NaBu regulates ZFP36-mediated cyclin B1 expression in a manner that is independent of the formation of P-bodies. sethoxydim 22-26 ZFP36 ring finger protein Homo sapiens 37-42 26555753-8 2015 Thus, we confirm that NaBu regulates ZFP36-mediated cyclin B1 expression in a manner that is independent of the formation of P-bodies. sethoxydim 22-26 cyclin B1 Homo sapiens 52-61 26021170-2 2015 Here, we demonstrated the activation of expression of the p21/Waf1 gene when the cells were treated to sodium butyrate (NaBu)--one of the natural inhibitors of deacetylase, and investigated whether this phenomenon depends on the presence of functionally active TP53 protein. sethoxydim 120-124 cyclin dependent kinase inhibitor 1A Homo sapiens 58-61 25700826-3 2015 Here, the effect of histone deacetylase inhibitor sodium butyrate (NaBu)-induced hyperacetylation on WT1 expression in porcine kidney fibroblasts (PKF) was examined. sethoxydim 67-71 WT1 transcription factor Sus scrofa 101-104 25700826-5 2015 WT1 mRNA levels were significantly elevated in NaBu-treated (1, 3 mM for 24, 48 h, respectively) PKF samples. sethoxydim 47-51 WT1 transcription factor Sus scrofa 0-3 25700826-6 2015 Consistently, strengthened expression of WT1 protein and histone acetylation level were detected in NaBu-treated PKF cells. sethoxydim 100-104 WT1 transcription factor Sus scrofa 41-44 25700826-7 2015 CONCLUSION: Together, NaBu-induced hyperacetylation up-regulates WT1 expression in PKF, suggesting the involvement of histone acetylation in the transcriptional modulation of WT1 in porcine kidney cells. sethoxydim 22-26 WT1 transcription factor Sus scrofa 65-68 25700826-7 2015 CONCLUSION: Together, NaBu-induced hyperacetylation up-regulates WT1 expression in PKF, suggesting the involvement of histone acetylation in the transcriptional modulation of WT1 in porcine kidney cells. sethoxydim 22-26 WT1 transcription factor Sus scrofa 175-178 23759515-7 2015 The treatment of NaBu also increased significantly the expression levels of Oct-4 and decreased the expression levels of HDAC-2, Dnmt-1 and IGF-1; the expression patterns of these genes were more similar to that of their bovine-yak in vitro fertilization (BY-IVF) counterparts. sethoxydim 17-21 POU domain, class 5, transcription factor 1 Bos taurus 76-81 23759515-7 2015 The treatment of NaBu also increased significantly the expression levels of Oct-4 and decreased the expression levels of HDAC-2, Dnmt-1 and IGF-1; the expression patterns of these genes were more similar to that of their bovine-yak in vitro fertilization (BY-IVF) counterparts. sethoxydim 17-21 histone deacetylase 2 Bos taurus 121-127 23759515-7 2015 The treatment of NaBu also increased significantly the expression levels of Oct-4 and decreased the expression levels of HDAC-2, Dnmt-1 and IGF-1; the expression patterns of these genes were more similar to that of their bovine-yak in vitro fertilization (BY-IVF) counterparts. sethoxydim 17-21 DNA methyltransferase 1 Bos taurus 129-135 23759515-7 2015 The treatment of NaBu also increased significantly the expression levels of Oct-4 and decreased the expression levels of HDAC-2, Dnmt-1 and IGF-1; the expression patterns of these genes were more similar to that of their bovine-yak in vitro fertilization (BY-IVF) counterparts. sethoxydim 17-21 insulin like growth factor 1 Bos taurus 140-145 26305601-9 2015 Interestingly, we identified that the two subpopulations show a differential sensitivity to HDAC inhibitors, NaBu or SAHA, with the CAIX positive showing greater sensitivity to treatment. sethoxydim 109-113 carbonic anhydrase 9 Homo sapiens 132-136 25557765-6 2015 Stimulation of LNCaP cells with NaBu evokes a significant increase in the expression of the Cav3.2 T-type channel subunits. sethoxydim 32-36 calcium voltage-gated channel subunit alpha1 H Homo sapiens 92-98 26021170-2 2015 Here, we demonstrated the activation of expression of the p21/Waf1 gene when the cells were treated to sodium butyrate (NaBu)--one of the natural inhibitors of deacetylase, and investigated whether this phenomenon depends on the presence of functionally active TP53 protein. sethoxydim 120-124 cyclin dependent kinase inhibitor 1A Homo sapiens 62-66 26021170-3 2015 We compared the effect of the NaBu treatment on the human cell line with different TP53 mutation profile, including: wild-type TP53, single nucleotide substitutions, and the complete absence of TP53 gene. sethoxydim 30-34 tumor protein p53 Homo sapiens 83-87 26021170-3 2015 We compared the effect of the NaBu treatment on the human cell line with different TP53 mutation profile, including: wild-type TP53, single nucleotide substitutions, and the complete absence of TP53 gene. sethoxydim 30-34 tumor protein p53 Homo sapiens 127-131 26021170-3 2015 We compared the effect of the NaBu treatment on the human cell line with different TP53 mutation profile, including: wild-type TP53, single nucleotide substitutions, and the complete absence of TP53 gene. sethoxydim 30-34 tumor protein p53 Homo sapiens 127-131 26021170-4 2015 NaBu activated the TP53 protein via hyper acetylation at lysine residue K382, without significant changes in the level of protein expression. sethoxydim 0-4 tumor protein p53 Homo sapiens 19-23 26021170-5 2015 Western blotting demonstrated that the addition of NaBu triggers a significant increase in the p21/Waf1 protein level in both the TP53 wild-type cells and in the cells with single nucleotide substitutions in the domain responsible for the binding of TP53 protein to DNA. sethoxydim 51-55 cyclin dependent kinase inhibitor 1A Homo sapiens 95-98 26021170-5 2015 Western blotting demonstrated that the addition of NaBu triggers a significant increase in the p21/Waf1 protein level in both the TP53 wild-type cells and in the cells with single nucleotide substitutions in the domain responsible for the binding of TP53 protein to DNA. sethoxydim 51-55 cyclin dependent kinase inhibitor 1A Homo sapiens 99-103 26021170-5 2015 Western blotting demonstrated that the addition of NaBu triggers a significant increase in the p21/Waf1 protein level in both the TP53 wild-type cells and in the cells with single nucleotide substitutions in the domain responsible for the binding of TP53 protein to DNA. sethoxydim 51-55 tumor protein p53 Homo sapiens 130-134 26021170-5 2015 Western blotting demonstrated that the addition of NaBu triggers a significant increase in the p21/Waf1 protein level in both the TP53 wild-type cells and in the cells with single nucleotide substitutions in the domain responsible for the binding of TP53 protein to DNA. sethoxydim 51-55 tumor protein p53 Homo sapiens 250-254 26021170-8 2015 Overall, our results suggest that the NaBu-dependent induction of p21/Waf1 does require the presence of TP53 protein but unexpectedly it can occur regardless of mutational changes in the domain responsible for the TP53 binding to DNA. sethoxydim 38-42 cyclin dependent kinase inhibitor 1A Homo sapiens 66-69 26021170-8 2015 Overall, our results suggest that the NaBu-dependent induction of p21/Waf1 does require the presence of TP53 protein but unexpectedly it can occur regardless of mutational changes in the domain responsible for the TP53 binding to DNA. sethoxydim 38-42 cyclin dependent kinase inhibitor 1A Homo sapiens 70-74 26021170-8 2015 Overall, our results suggest that the NaBu-dependent induction of p21/Waf1 does require the presence of TP53 protein but unexpectedly it can occur regardless of mutational changes in the domain responsible for the TP53 binding to DNA. sethoxydim 38-42 tumor protein p53 Homo sapiens 104-108 26021170-8 2015 Overall, our results suggest that the NaBu-dependent induction of p21/Waf1 does require the presence of TP53 protein but unexpectedly it can occur regardless of mutational changes in the domain responsible for the TP53 binding to DNA. sethoxydim 38-42 tumor protein p53 Homo sapiens 214-218 26021170-9 2015 One of the hypothetical explanations is that NaBu increases the level of TP53 acetylation, and the modified protein is able to establish a new network of protein-protein interactions or trigger some conformational changes affecting the TP53-dependent transcriptional machinery even when its DNA binding ability is impaired. sethoxydim 45-49 tumor protein p53 Homo sapiens 73-77 26021170-9 2015 One of the hypothetical explanations is that NaBu increases the level of TP53 acetylation, and the modified protein is able to establish a new network of protein-protein interactions or trigger some conformational changes affecting the TP53-dependent transcriptional machinery even when its DNA binding ability is impaired. sethoxydim 45-49 tumor protein p53 Homo sapiens 236-240 25342743-12 2014 Overexpression of the p300/cAMP-response element-binding protein-binding protein (CBP) potentiated the NaBu-mediated transactivation potential of Sp1/Sp3, but expressing several HDACs attenuated this effect, suggesting that p300/CBP and HDACs act as coactivators or corepressors in histone acetylation-induced PKCdelta up-regulation. sethoxydim 103-107 E1A binding protein p300 Homo sapiens 22-26 25342743-12 2014 Overexpression of the p300/cAMP-response element-binding protein-binding protein (CBP) potentiated the NaBu-mediated transactivation potential of Sp1/Sp3, but expressing several HDACs attenuated this effect, suggesting that p300/CBP and HDACs act as coactivators or corepressors in histone acetylation-induced PKCdelta up-regulation. sethoxydim 103-107 CREB binding protein Homo sapiens 229-232 25342743-12 2014 Overexpression of the p300/cAMP-response element-binding protein-binding protein (CBP) potentiated the NaBu-mediated transactivation potential of Sp1/Sp3, but expressing several HDACs attenuated this effect, suggesting that p300/CBP and HDACs act as coactivators or corepressors in histone acetylation-induced PKCdelta up-regulation. sethoxydim 103-107 protein kinase C delta Homo sapiens 310-318 25342743-13 2014 Finally, using genetic and pharmacological approaches, we showed that NaBu up-regulation of PKCdelta sensitizes neurons to cell death in a human dopaminergic cell model and brain slice cultures. sethoxydim 70-74 protein kinase C delta Homo sapiens 92-100 23359532-7 2014 Moreover, the addition of NaBu significantly enhanced ADR cytotoxicity for the primary uterine cancer cells with high hTERT expression. sethoxydim 26-30 telomerase reverse transcriptase Homo sapiens 118-123 25342743-4 2014 Treatment with histone deacetylase (HDAC) inhibitor sodium butyrate (NaBu) induced PKCdelta expression in cultured neurons, brain slices, and animal models. sethoxydim 69-73 protein kinase C delta Homo sapiens 83-91 25342743-6 2014 The chromatin immunoprecipitation analysis revealed that hyperacetylation of histone H4 by NaBu is associated with the PKCdelta promoter. sethoxydim 91-95 H4 clustered histone 6 Homo sapiens 77-87 25342743-6 2014 The chromatin immunoprecipitation analysis revealed that hyperacetylation of histone H4 by NaBu is associated with the PKCdelta promoter. sethoxydim 91-95 protein kinase C delta Homo sapiens 119-127 25342743-7 2014 Deletion analysis of the PKCdelta promoter mapped the NaBu-responsive element to an 81-bp minimal promoter region. sethoxydim 54-58 protein kinase C delta Homo sapiens 25-33 25342743-9 2014 Cotransfection experiments and Sp inhibitor studies demonstrated that Sp1, Sp3, and Sp4 regulated NaBu-induced PKCdelta up-regulation. sethoxydim 98-102 Sp3 transcription factor Homo sapiens 75-78 25342743-9 2014 Cotransfection experiments and Sp inhibitor studies demonstrated that Sp1, Sp3, and Sp4 regulated NaBu-induced PKCdelta up-regulation. sethoxydim 98-102 Sp4 transcription factor Homo sapiens 84-87 25342743-9 2014 Cotransfection experiments and Sp inhibitor studies demonstrated that Sp1, Sp3, and Sp4 regulated NaBu-induced PKCdelta up-regulation. sethoxydim 98-102 protein kinase C delta Homo sapiens 111-119 25342743-12 2014 Overexpression of the p300/cAMP-response element-binding protein-binding protein (CBP) potentiated the NaBu-mediated transactivation potential of Sp1/Sp3, but expressing several HDACs attenuated this effect, suggesting that p300/CBP and HDACs act as coactivators or corepressors in histone acetylation-induced PKCdelta up-regulation. sethoxydim 103-107 CREB binding protein Homo sapiens 22-80 25342743-12 2014 Overexpression of the p300/cAMP-response element-binding protein-binding protein (CBP) potentiated the NaBu-mediated transactivation potential of Sp1/Sp3, but expressing several HDACs attenuated this effect, suggesting that p300/CBP and HDACs act as coactivators or corepressors in histone acetylation-induced PKCdelta up-regulation. sethoxydim 103-107 CREB binding protein Homo sapiens 82-85 25342743-12 2014 Overexpression of the p300/cAMP-response element-binding protein-binding protein (CBP) potentiated the NaBu-mediated transactivation potential of Sp1/Sp3, but expressing several HDACs attenuated this effect, suggesting that p300/CBP and HDACs act as coactivators or corepressors in histone acetylation-induced PKCdelta up-regulation. sethoxydim 103-107 Sp3 transcription factor Homo sapiens 150-153 23359532-8 2014 These data indicate that downregulation of hTERT is an important part of the mechanism by which NaBu enhances ADR-induced apoptosis, and suggests that combining NaBu and ADR may be effective in treating uterine tumor with high telomerase activity. sethoxydim 96-100 telomerase reverse transcriptase Homo sapiens 43-48 23064206-6 2012 Thus, we used NaBu to investigate the relationship between the status of cell proliferation and the re-expression of ASC in colon carcinoma LS174T cells. sethoxydim 14-18 PYD and CARD domain containing Homo sapiens 141-144 24494796-6 2014 We found that NaBu promoted rat ADSC osteogenic differentiation by altering the epigenetic modifications on the Runx2 promoter. sethoxydim 14-18 RUNX family transcription factor 2 Rattus norvegicus 112-117 24333461-5 2014 Altered expression patterns in st3gal3, neu1, and neu3, which have roles in the sialic acid biosynthesis pathway, correlated with reduced sialic acid content of the glycoprotein by NaBu. sethoxydim 181-185 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase Cricetulus griseus 31-38 24333461-5 2014 Altered expression patterns in st3gal3, neu1, and neu3, which have roles in the sialic acid biosynthesis pathway, correlated with reduced sialic acid content of the glycoprotein by NaBu. sethoxydim 181-185 sialidase-1 Cricetulus griseus 40-44 24333461-5 2014 Altered expression patterns in st3gal3, neu1, and neu3, which have roles in the sialic acid biosynthesis pathway, correlated with reduced sialic acid content of the glycoprotein by NaBu. sethoxydim 181-185 sialidase-3 Cricetulus griseus 50-54 24714214-4 2014 ATRA and NaBu promoted global acetylation of histones H3-K9/14 and H4-K12, reduced methylation of H3-K9 and H3-K27, and enriched accumulation of active chromatin marks at the Npr1 promoter. sethoxydim 9-13 natriuretic peptide receptor 1 Mus musculus 175-179 24714214-7 2014 Treatment with ATRA and NaBu synergistically attenuated the expression of alpha-SMA and PCNA and reduced systolic blood pressure in Npr1(+/-) mice. sethoxydim 24-28 actin alpha 2, smooth muscle, aorta Mus musculus 74-83 24714214-7 2014 Treatment with ATRA and NaBu synergistically attenuated the expression of alpha-SMA and PCNA and reduced systolic blood pressure in Npr1(+/-) mice. sethoxydim 24-28 proliferating cell nuclear antigen Mus musculus 88-92 24714214-7 2014 Treatment with ATRA and NaBu synergistically attenuated the expression of alpha-SMA and PCNA and reduced systolic blood pressure in Npr1(+/-) mice. sethoxydim 24-28 natriuretic peptide receptor 1 Mus musculus 132-136 24714214-8 2014 Our findings demonstrate that epigenetic upregulation of Npr1 gene transcription by ATRA and NaBu leads to attenuation of renal fibrotic markers and systolic blood pressure in mice with reduced Npr1 gene copy number, which will have important implications in prevention and treatment of hypertension-related renal pathophysiological conditions. sethoxydim 93-97 natriuretic peptide receptor 1 Mus musculus 57-61 24212060-3 2014 In a further experiment, we compared the effects of two different doses of NaBu (200 and 1200 mg/kg) and equimolar saline solutions on peripheral neuroendocrine markers and brain c-Fos expression to demonstrate a specific stress-like effect of NaBu that is not related to hypertonicity and to localise putatively involved brain areas. sethoxydim 75-79 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 179-184 24212060-7 2014 However, only the latter area of the NaBu group showed enhanced c-Fos expression that was significantly higher than that after hypertonic saline. sethoxydim 37-41 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 64-69 23943192-7 2014 Meanwhile, Bcl-2, Caspase-3, and Caspase-9 were in the U373-MG and T98G lines expressed after NaBu treatment. sethoxydim 94-98 BCL2 apoptosis regulator Homo sapiens 11-16 23943192-7 2014 Meanwhile, Bcl-2, Caspase-3, and Caspase-9 were in the U373-MG and T98G lines expressed after NaBu treatment. sethoxydim 94-98 caspase 3 Homo sapiens 18-27 23943192-7 2014 Meanwhile, Bcl-2, Caspase-3, and Caspase-9 were in the U373-MG and T98G lines expressed after NaBu treatment. sethoxydim 94-98 caspase 9 Homo sapiens 33-42 23943192-8 2014 The effect of 5-aza induced an increase in the expression of Bax and Bcl-2, while NaBu produced a similar effect on the Bak-1 and Bax genes. sethoxydim 82-86 BCL2 antagonist/killer 1 Homo sapiens 120-125 23943192-8 2014 The effect of 5-aza induced an increase in the expression of Bax and Bcl-2, while NaBu produced a similar effect on the Bak-1 and Bax genes. sethoxydim 82-86 BCL2 associated X, apoptosis regulator Homo sapiens 130-133 23940089-7 2013 Incubation of HL-60 cells with NaBu was associated with increased level of pro-apoptotic protein BIMEL and decreased levels of anti-apoptotic proteins of Bcl-2 family as well as GRP78 involved in ER stress signalling. sethoxydim 31-35 BCL2 apoptosis regulator Homo sapiens 154-159 23940089-7 2013 Incubation of HL-60 cells with NaBu was associated with increased level of pro-apoptotic protein BIMEL and decreased levels of anti-apoptotic proteins of Bcl-2 family as well as GRP78 involved in ER stress signalling. sethoxydim 31-35 heat shock protein family A (Hsp70) member 5 Homo sapiens 178-183 23940089-8 2013 It seems that ABT-737 accelerates NaBu-induced death of HL-60 cells due to mitochondrial apoptosis resulting from ABT-737-mediated inhibition of functions and NaBu-induced decrease of the levels of anti-apoptotic Bcl-2 family proteins as well as due to accelerated decrease of GRP78 observed after the treatment of cells with combination of NaBu and ABT-737. sethoxydim 34-38 BCL2 apoptosis regulator Homo sapiens 213-218 23940089-8 2013 It seems that ABT-737 accelerates NaBu-induced death of HL-60 cells due to mitochondrial apoptosis resulting from ABT-737-mediated inhibition of functions and NaBu-induced decrease of the levels of anti-apoptotic Bcl-2 family proteins as well as due to accelerated decrease of GRP78 observed after the treatment of cells with combination of NaBu and ABT-737. sethoxydim 34-38 heat shock protein family A (Hsp70) member 5 Homo sapiens 277-282 23940089-8 2013 It seems that ABT-737 accelerates NaBu-induced death of HL-60 cells due to mitochondrial apoptosis resulting from ABT-737-mediated inhibition of functions and NaBu-induced decrease of the levels of anti-apoptotic Bcl-2 family proteins as well as due to accelerated decrease of GRP78 observed after the treatment of cells with combination of NaBu and ABT-737. sethoxydim 159-163 BCL2 apoptosis regulator Homo sapiens 213-218 23940089-8 2013 It seems that ABT-737 accelerates NaBu-induced death of HL-60 cells due to mitochondrial apoptosis resulting from ABT-737-mediated inhibition of functions and NaBu-induced decrease of the levels of anti-apoptotic Bcl-2 family proteins as well as due to accelerated decrease of GRP78 observed after the treatment of cells with combination of NaBu and ABT-737. sethoxydim 159-163 heat shock protein family A (Hsp70) member 5 Homo sapiens 277-282 23940089-8 2013 It seems that ABT-737 accelerates NaBu-induced death of HL-60 cells due to mitochondrial apoptosis resulting from ABT-737-mediated inhibition of functions and NaBu-induced decrease of the levels of anti-apoptotic Bcl-2 family proteins as well as due to accelerated decrease of GRP78 observed after the treatment of cells with combination of NaBu and ABT-737. sethoxydim 159-163 BCL2 apoptosis regulator Homo sapiens 213-218 23940089-8 2013 It seems that ABT-737 accelerates NaBu-induced death of HL-60 cells due to mitochondrial apoptosis resulting from ABT-737-mediated inhibition of functions and NaBu-induced decrease of the levels of anti-apoptotic Bcl-2 family proteins as well as due to accelerated decrease of GRP78 observed after the treatment of cells with combination of NaBu and ABT-737. sethoxydim 159-163 heat shock protein family A (Hsp70) member 5 Homo sapiens 277-282 23528351-9 2013 In addition, chronic treatment with NaBu significantly attenuated gentamicin-induced nephrotoxicity by increasing activities of superoxide dismutase, catalase and reduced glutathione. sethoxydim 36-40 catalase Rattus norvegicus 150-158 23440283-2 2013 As a histone deacetylase (HDAC) inhibitor, NaBu upregulated Ac-H3 and inhibited HDAC4 protein expression in a time- and dose-dependent manner. sethoxydim 43-47 histone deacetylase 4 Homo sapiens 80-85 23440283-10 2013 The EMT markers, E-cadherin, vimentin and N-cadherin, were regulated by TGF-beta1, while NaBu inhibited this process in which HDAC4 and matrix metalloproteinase (MMP)7 may be involved. sethoxydim 89-93 histone deacetylase 4 Homo sapiens 126-131 23440283-10 2013 The EMT markers, E-cadherin, vimentin and N-cadherin, were regulated by TGF-beta1, while NaBu inhibited this process in which HDAC4 and matrix metalloproteinase (MMP)7 may be involved. sethoxydim 89-93 matrix metallopeptidase 7 Homo sapiens 136-167 23064206-10 2012 The results showed that ASC re-expression was significantly increased in the LS174 cells following NaBu treatment in a time- and dose-dependent manner. sethoxydim 111-115 PYD and CARD domain containing Homo sapiens 24-27 23064206-12 2012 These results suggest that NaBu plays a role in the reactivation of ASC expression and that the latter promotes the apoptosis of LS174T cells. sethoxydim 27-31 PYD and CARD domain containing Homo sapiens 80-83 22728390-3 2012 With NaBu treatment, co-down-regulation of caspase-3/7 enhanced autophagy induction, whereas Bcl-2 overexpression delayed onset of autophagy induction in a Beclin-1 independent manner. sethoxydim 5-9 caspase 3 Rattus norvegicus 43-52 22710635-6 2012 NaBu induced expression of caspase-3, caspase-9, and Bcl-2 and increased Bax in U373-MG cells. sethoxydim 0-4 caspase 3 Homo sapiens 27-36 22710635-6 2012 NaBu induced expression of caspase-3, caspase-9, and Bcl-2 and increased Bax in U373-MG cells. sethoxydim 0-4 caspase 9 Homo sapiens 38-47 22710635-6 2012 NaBu induced expression of caspase-3, caspase-9, and Bcl-2 and increased Bax in U373-MG cells. sethoxydim 0-4 BCL2 apoptosis regulator Homo sapiens 53-58 22710635-6 2012 NaBu induced expression of caspase-3, caspase-9, and Bcl-2 and increased Bax in U373-MG cells. sethoxydim 0-4 BCL2 associated X, apoptosis regulator Homo sapiens 73-76 22386365-3 2012 Therefore, we studied the effect of sodium butyrate (NaBu) on the CYP19A1 transcript and protein levels and on the conversion of A to E1 in HT29, DLD-1 and LoVo CRC cells. sethoxydim 53-57 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 66-73 22544719-9 2012 NaBu-treated SCNT embryos showed similar levels of Oct4, Bcl-2, and Dnmt3b as in IVF blastocysts. sethoxydim 0-4 POU class 5 homeobox 1 Homo sapiens 51-55 22544719-9 2012 NaBu-treated SCNT embryos showed similar levels of Oct4, Bcl-2, and Dnmt3b as in IVF blastocysts. sethoxydim 0-4 BCL2 apoptosis regulator Homo sapiens 57-62 22544719-9 2012 NaBu-treated SCNT embryos showed similar levels of Oct4, Bcl-2, and Dnmt3b as in IVF blastocysts. sethoxydim 0-4 DNA methyltransferase 3 beta Homo sapiens 68-74 22228088-3 2012 In two different HCC cell lines, SK-Hep1 and SMMC-7721, low concentrations of NaBu induced a significant increase in cell growth ratio and S-phase cell percentage, accompanied by a reduced p21 Cip1 expression at both mRNA and protein levels, while dissimilarly, high concentrations of NaBu inhibited cell growth and induced G1 arrest through up-regulation of p21 Cip1 and p27 Kip1 protein expression. sethoxydim 78-82 DNL-type zinc finger Homo sapiens 36-40 22228088-3 2012 In two different HCC cell lines, SK-Hep1 and SMMC-7721, low concentrations of NaBu induced a significant increase in cell growth ratio and S-phase cell percentage, accompanied by a reduced p21 Cip1 expression at both mRNA and protein levels, while dissimilarly, high concentrations of NaBu inhibited cell growth and induced G1 arrest through up-regulation of p21 Cip1 and p27 Kip1 protein expression. sethoxydim 78-82 cyclin dependent kinase inhibitor 1A Homo sapiens 189-192 22228088-3 2012 In two different HCC cell lines, SK-Hep1 and SMMC-7721, low concentrations of NaBu induced a significant increase in cell growth ratio and S-phase cell percentage, accompanied by a reduced p21 Cip1 expression at both mRNA and protein levels, while dissimilarly, high concentrations of NaBu inhibited cell growth and induced G1 arrest through up-regulation of p21 Cip1 and p27 Kip1 protein expression. sethoxydim 78-82 cyclin dependent kinase inhibitor 1A Homo sapiens 193-197 22228088-3 2012 In two different HCC cell lines, SK-Hep1 and SMMC-7721, low concentrations of NaBu induced a significant increase in cell growth ratio and S-phase cell percentage, accompanied by a reduced p21 Cip1 expression at both mRNA and protein levels, while dissimilarly, high concentrations of NaBu inhibited cell growth and induced G1 arrest through up-regulation of p21 Cip1 and p27 Kip1 protein expression. sethoxydim 78-82 cyclin dependent kinase inhibitor 1A Homo sapiens 189-197 22228088-3 2012 In two different HCC cell lines, SK-Hep1 and SMMC-7721, low concentrations of NaBu induced a significant increase in cell growth ratio and S-phase cell percentage, accompanied by a reduced p21 Cip1 expression at both mRNA and protein levels, while dissimilarly, high concentrations of NaBu inhibited cell growth and induced G1 arrest through up-regulation of p21 Cip1 and p27 Kip1 protein expression. sethoxydim 78-82 cyclin dependent kinase inhibitor 1B Homo sapiens 372-380 22228088-4 2012 The reduction of p45 Skp2 expression further indicated that the ubiquitin-mediated protein degradation might play a role in NaBu-induced up-regulation of p21 Cip1 and p27 Kip1. sethoxydim 124-128 S-phase kinase associated protein 2 Homo sapiens 17-25 22228088-4 2012 The reduction of p45 Skp2 expression further indicated that the ubiquitin-mediated protein degradation might play a role in NaBu-induced up-regulation of p21 Cip1 and p27 Kip1. sethoxydim 124-128 cyclin dependent kinase inhibitor 1A Homo sapiens 154-162 22228088-4 2012 The reduction of p45 Skp2 expression further indicated that the ubiquitin-mediated protein degradation might play a role in NaBu-induced up-regulation of p21 Cip1 and p27 Kip1. sethoxydim 124-128 cyclin dependent kinase inhibitor 1B Homo sapiens 167-175 22386365-4 2012 We found that NaBu significantly downregulated CYP19A1 transcript and protein levels, a phenomenon that was associated with reduced conversion of A to E1 in HT29, DLD-1 and LoVo cells. sethoxydim 14-18 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 47-54 22492702-4 2012 NaBu treatment up to 5 mM increased cleaved forms of PARP, caspase-3, and Annexin V positive population, confirming the previous results that NaBu induces apoptosis. sethoxydim 0-4 poly [ADP-ribose] polymerase 1 Cricetulus griseus 53-57 22492702-4 2012 NaBu treatment up to 5 mM increased cleaved forms of PARP, caspase-3, and Annexin V positive population, confirming the previous results that NaBu induces apoptosis. sethoxydim 0-4 caspase-3 Cricetulus griseus 59-68 20512937-4 2010 Sodium butyrate (NaBu) or anti-arrhythmic peptide (AAP10) were used to enhance Cx expression in HeLa cells stably expressing Cx43 (HeLa-43) and primary cultures of human fibroblasts (HFF) that predominantly express Cx43. sethoxydim 17-21 gap junction protein alpha 1 Homo sapiens 125-129 25961265-9 2011 Furthermore, NaBu down-regulates the proto-oncogenes c-Myc, Cyclin D1 and E2F1 mRNA levels. sethoxydim 13-17 MYC proto-oncogene, bHLH transcription factor Homo sapiens 53-58 25961265-9 2011 Furthermore, NaBu down-regulates the proto-oncogenes c-Myc, Cyclin D1 and E2F1 mRNA levels. sethoxydim 13-17 cyclin D1 Homo sapiens 60-69 25961265-9 2011 Furthermore, NaBu down-regulates the proto-oncogenes c-Myc, Cyclin D1 and E2F1 mRNA levels. sethoxydim 13-17 E2F transcription factor 1 Homo sapiens 74-78 20881297-7 2011 RESULTS: Differential induction of gene expression between 17Syn(+) and its mutant 17DeltaPst(LAT(-)) was designated as NaBu-induced gene expression and yielded significant upregulation of 2- to 16-fold of 0.4% (56/14,000) host genes probed, comprising mainly nucleosome assembly and binding, central nervous system structural activity, hormonal activity, and signaling activity. sethoxydim 120-124 linker for activation of T cells Homo sapiens 94-97 20881297-10 2011 Euchromatin analysis revealed that the LAT-ICP0 locus is amenable to the effects of NaBu. sethoxydim 84-88 linker for activation of T cells Homo sapiens 39-47 22253909-4 2012 Forty percent of the NaBu resistant cells express the cancer stem cells marker, the CD133, whereas only 10% intact cells present the CD133 antigen. sethoxydim 21-25 prominin 1 Mus musculus 84-89 22253909-5 2012 Furthermore, the endogenous expressing c-MET contributes to the survival of cancer stem cell population from the treatment of NaBu. sethoxydim 126-130 met proto-oncogene Mus musculus 39-44 21723342-8 2011 The expression of Bcl-2 was enhanced by the addition of NaBu in a dose-dependent manner while it was not affected by the withdrawal of GF. sethoxydim 56-60 apoptosis regulator Bcl-2 Cricetulus griseus 18-23 21555914-1 2011 Sodium butyrate (NaBu) is a histone deacetylase inhibitor that exhibits numerous antiproliferative activities in various cancer cell lines, notably through the accumulation of the well-known cyclin-dependent kinase inhibitor p21(WAF1) . sethoxydim 17-21 proliferating cell nuclear antigen Homo sapiens 191-197 21555914-1 2011 Sodium butyrate (NaBu) is a histone deacetylase inhibitor that exhibits numerous antiproliferative activities in various cancer cell lines, notably through the accumulation of the well-known cyclin-dependent kinase inhibitor p21(WAF1) . sethoxydim 17-21 cyclin dependent kinase inhibitor 1A Homo sapiens 225-228 21555914-1 2011 Sodium butyrate (NaBu) is a histone deacetylase inhibitor that exhibits numerous antiproliferative activities in various cancer cell lines, notably through the accumulation of the well-known cyclin-dependent kinase inhibitor p21(WAF1) . sethoxydim 17-21 cyclin dependent kinase inhibitor 1A Homo sapiens 229-233 21555914-4 2011 In this study, we show that NaBu also induces the accumulation of SRSF2 in human lung carcinoma cell lines. sethoxydim 28-32 serine and arginine rich splicing factor 2 Homo sapiens 66-71 21555914-6 2011 Here, we show that the same signaling pathway controls SRSF2 protein expression upon NaBu treatment. sethoxydim 85-89 serine and arginine rich splicing factor 2 Homo sapiens 55-60 21555914-7 2011 Importantly, we further demonstrate that SRSF2 is required for the accumulation of p21(WAF1) at both mRNA and protein levels in response to NaBu. sethoxydim 140-144 serine and arginine rich splicing factor 2 Homo sapiens 41-46 21555914-7 2011 Importantly, we further demonstrate that SRSF2 is required for the accumulation of p21(WAF1) at both mRNA and protein levels in response to NaBu. sethoxydim 140-144 cyclin dependent kinase inhibitor 1A Homo sapiens 83-86 21555914-7 2011 Importantly, we further demonstrate that SRSF2 is required for the accumulation of p21(WAF1) at both mRNA and protein levels in response to NaBu. sethoxydim 140-144 cyclin dependent kinase inhibitor 1A Homo sapiens 87-91 21555914-8 2011 Finally, we provide evidence that a long-term NaBu-treatment triggers senescence in our cellular models, a phenomenon that is prevented by the knockdown of SRSF2. sethoxydim 46-50 serine and arginine rich splicing factor 2 Homo sapiens 156-161 20383178-5 2010 In this study, we show that the expression of mda-7/IL-24 was upregulated by the histone deacetylase (HDAC) inhibitors trichostatin A (TSA) and sodium butyrate (NaBu), whereas it was downregulated by HDAC4. sethoxydim 161-165 interleukin 24 Homo sapiens 46-51 20383178-5 2010 In this study, we show that the expression of mda-7/IL-24 was upregulated by the histone deacetylase (HDAC) inhibitors trichostatin A (TSA) and sodium butyrate (NaBu), whereas it was downregulated by HDAC4. sethoxydim 161-165 interleukin 24 Homo sapiens 52-57 19739093-1 2010 Bcl-x(L), a member of the Bcl-2 family, is known to inhibit apoptosis of recombinant Chinese hamster ovary (rCHO) cells induced by the addition of sodium butyrate (NaBu), which is used for the elevated expression of recombinant protein. sethoxydim 164-168 bcl-2-like protein 1 Cricetulus griseus 0-8 19739093-2 2010 In order to understand the intracellular effects of Bcl-x(L) overexpression on CHO cells treated with NaBu, changes to the proteome caused by controlled Bcl-x(L) expression in rCHO cells producing erythropoietin (EPO) in the presence of 3 mM NaBu were evaluated using two-dimensional differential in-gel electrophoresis (2D-DIGE) and MS analysis. sethoxydim 102-106 bcl-2-like protein 1 Cricetulus griseus 52-60 19739093-2 2010 In order to understand the intracellular effects of Bcl-x(L) overexpression on CHO cells treated with NaBu, changes to the proteome caused by controlled Bcl-x(L) expression in rCHO cells producing erythropoietin (EPO) in the presence of 3 mM NaBu were evaluated using two-dimensional differential in-gel electrophoresis (2D-DIGE) and MS analysis. sethoxydim 102-106 erythropoietin Rattus norvegicus 197-211 19739093-2 2010 In order to understand the intracellular effects of Bcl-x(L) overexpression on CHO cells treated with NaBu, changes to the proteome caused by controlled Bcl-x(L) expression in rCHO cells producing erythropoietin (EPO) in the presence of 3 mM NaBu were evaluated using two-dimensional differential in-gel electrophoresis (2D-DIGE) and MS analysis. sethoxydim 242-246 erythropoietin Rattus norvegicus 197-211 19739093-4 2010 Out of eight proteins regulated significantly by Bcl-x(L) overexpression in 3 mM NaBu addition culture, four proteins were related to cell survival (Iq motif-containing GTPase-activating protein 1), cell proliferation (dihydrolipoamide-S-acetyltransferase, guanine nucleotide binding protein alpha interacting 2), and repair of DNA damage (BRCA and CDKN1A interacting protein). sethoxydim 81-85 Bcl2-like 1 Rattus norvegicus 49-57 19739093-4 2010 Out of eight proteins regulated significantly by Bcl-x(L) overexpression in 3 mM NaBu addition culture, four proteins were related to cell survival (Iq motif-containing GTPase-activating protein 1), cell proliferation (dihydrolipoamide-S-acetyltransferase, guanine nucleotide binding protein alpha interacting 2), and repair of DNA damage (BRCA and CDKN1A interacting protein). sethoxydim 81-85 IQ motif containing GTPase activating protein 1 Rattus norvegicus 149-196 19739093-4 2010 Out of eight proteins regulated significantly by Bcl-x(L) overexpression in 3 mM NaBu addition culture, four proteins were related to cell survival (Iq motif-containing GTPase-activating protein 1), cell proliferation (dihydrolipoamide-S-acetyltransferase, guanine nucleotide binding protein alpha interacting 2), and repair of DNA damage (BRCA and CDKN1A interacting protein). sethoxydim 81-85 dihydrolipoamide S-acetyltransferase Rattus norvegicus 219-255 19739093-5 2010 Taken together, a DIGE approach reveals that overexpression of Bcl-x(L) not only inhibits apoptosis in the presence of NaBu but also affects cell proliferation and survival in various aspects. sethoxydim 119-123 Bcl2-like 1 Rattus norvegicus 63-71 17595767-2 2007 The effect of the histone deacetylation inhibitor, sodium butyrate (NaBu) on oral cancer cell (OCC) HSC-3 and HSC-4 proliferation in vitro was investigated. sethoxydim 68-72 DnaJ heat shock protein family (Hsp40) member B7 Homo sapiens 100-105 19799944-2 2009 In this study, the potential role of XIAP overexpression in recombinant CHO (rCHO) cells treated with sodium butyrate (NaBu), which can increase the specific productivity, was investigated by establishing erythropoietin (EPO)-producing rCHO cells with regulated XIAP overexpression (EPO-off-XIAP). sethoxydim 119-123 E3 ubiquitin-protein ligase XIAP Cricetulus griseus 37-41 19799944-2 2009 In this study, the potential role of XIAP overexpression in recombinant CHO (rCHO) cells treated with sodium butyrate (NaBu), which can increase the specific productivity, was investigated by establishing erythropoietin (EPO)-producing rCHO cells with regulated XIAP overexpression (EPO-off-XIAP). sethoxydim 119-123 erythropoietin Rattus norvegicus 205-219 19799944-2 2009 In this study, the potential role of XIAP overexpression in recombinant CHO (rCHO) cells treated with sodium butyrate (NaBu), which can increase the specific productivity, was investigated by establishing erythropoietin (EPO)-producing rCHO cells with regulated XIAP overexpression (EPO-off-XIAP). sethoxydim 119-123 erythropoietin Rattus norvegicus 221-224 19799944-2 2009 In this study, the potential role of XIAP overexpression in recombinant CHO (rCHO) cells treated with sodium butyrate (NaBu), which can increase the specific productivity, was investigated by establishing erythropoietin (EPO)-producing rCHO cells with regulated XIAP overexpression (EPO-off-XIAP). sethoxydim 119-123 X-linked inhibitor of apoptosis Rattus norvegicus 262-266 19799944-2 2009 In this study, the potential role of XIAP overexpression in recombinant CHO (rCHO) cells treated with sodium butyrate (NaBu), which can increase the specific productivity, was investigated by establishing erythropoietin (EPO)-producing rCHO cells with regulated XIAP overexpression (EPO-off-XIAP). sethoxydim 119-123 erythropoietin Rattus norvegicus 283-286 19799944-2 2009 In this study, the potential role of XIAP overexpression in recombinant CHO (rCHO) cells treated with sodium butyrate (NaBu), which can increase the specific productivity, was investigated by establishing erythropoietin (EPO)-producing rCHO cells with regulated XIAP overexpression (EPO-off-XIAP). sethoxydim 119-123 X-linked inhibitor of apoptosis Rattus norvegicus 262-266 19799944-4 2009 The XIAP overexpression could simultaneously reduce the activation of caspase-3, -7, and -9 induced by NaBu addition. sethoxydim 103-107 E3 ubiquitin-protein ligase XIAP Cricetulus griseus 4-8 19799944-4 2009 The XIAP overexpression could simultaneously reduce the activation of caspase-3, -7, and -9 induced by NaBu addition. sethoxydim 103-107 caspase-3 Cricetulus griseus 70-91 18663604-2 2009 In this study, the potential role of calnexin (Cnx) expression in rCHO cells treated with 5 mM NaBu was investigated for rCHO cells producing tumor necrosis factor receptor FC. sethoxydim 95-99 calnexin Rattus norvegicus 37-45 18663604-2 2009 In this study, the potential role of calnexin (Cnx) expression in rCHO cells treated with 5 mM NaBu was investigated for rCHO cells producing tumor necrosis factor receptor FC. sethoxydim 95-99 calnexin Rattus norvegicus 47-50 18663604-6 2009 Under NaBu treatment, Cnx overexpression further enhanced the q (p) by about 1.7-fold. sethoxydim 6-10 calnexin Rattus norvegicus 22-25 18663604-7 2009 However, under NaBu stress, the cells overexpressing Cnx showed a poorer viability profile with a consistent difference of over 25% in the viability when compared to the Cnx-repressed condition. sethoxydim 15-19 calnexin Rattus norvegicus 53-56 18663604-10 2009 Taken together, Cnx overexpression not only improved the q (p) of cells treated with NaBu, but it also sensitized cells to apoptosis. sethoxydim 85-89 calnexin Rattus norvegicus 16-19 19098451-7 2008 In contrast, administration of NaBu increased levels of p21(WAF1) mRNA and p21(WAF1) protein, and was associated with an accumulation of histone acetylation. sethoxydim 31-35 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 56-59 19098451-7 2008 In contrast, administration of NaBu increased levels of p21(WAF1) mRNA and p21(WAF1) protein, and was associated with an accumulation of histone acetylation. sethoxydim 31-35 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 60-64 19098451-7 2008 In contrast, administration of NaBu increased levels of p21(WAF1) mRNA and p21(WAF1) protein, and was associated with an accumulation of histone acetylation. sethoxydim 31-35 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 75-78 19098451-7 2008 In contrast, administration of NaBu increased levels of p21(WAF1) mRNA and p21(WAF1) protein, and was associated with an accumulation of histone acetylation. sethoxydim 31-35 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 79-83 18555711-2 2008 In this study, we investigated the mechanisms involved in NaBu-induced activation of erythroid-specific 5-aminolevulinate synthase gene (ALAS2). sethoxydim 58-62 5'-aminolevulinate synthase 2 Homo sapiens 137-142 18555711-3 2008 We showed that NaBu upregulated ALAS2 gene transcription in different cell lineages. sethoxydim 15-19 5'-aminolevulinate synthase 2 Homo sapiens 32-37 18555711-4 2008 By using site-directed mutagenesis of putative responsive elements at ALAS2 promoter and reporter gene analysis, we identified that the Sp1 binding sites within the ALAS2 promoter were responsive to NaBu stimulation. sethoxydim 199-203 5'-aminolevulinate synthase 2 Homo sapiens 70-75 18555711-4 2008 By using site-directed mutagenesis of putative responsive elements at ALAS2 promoter and reporter gene analysis, we identified that the Sp1 binding sites within the ALAS2 promoter were responsive to NaBu stimulation. sethoxydim 199-203 5'-aminolevulinate synthase 2 Homo sapiens 165-170 18555711-5 2008 Results from the chromatin immunoprecipitation (ChIP) assays indicated that upon the NaBu stimulation, binding of Sp1 protein to ALAS2 promoter increased significantly, with concurrent increases in acetylation level of histone H3 and dimethylation level of H3-Lysine4 at ALAS2 promoter. sethoxydim 85-89 5'-aminolevulinate synthase 2 Homo sapiens 129-134 18555711-5 2008 Results from the chromatin immunoprecipitation (ChIP) assays indicated that upon the NaBu stimulation, binding of Sp1 protein to ALAS2 promoter increased significantly, with concurrent increases in acetylation level of histone H3 and dimethylation level of H3-Lysine4 at ALAS2 promoter. sethoxydim 85-89 5'-aminolevulinate synthase 2 Homo sapiens 271-276 18555711-6 2008 Also, our data suggested that HDAC1 may be a target enzyme of NaBu action. sethoxydim 62-66 histone deacetylase 1 Homo sapiens 30-35 20625486-2 2010 Thus, the influence of NaBu on the production of recombinant human prolactin (hPRL) from CHO cells was investigated for the first time. sethoxydim 23-27 prolactin Homo sapiens 67-76 20625486-2 2010 Thus, the influence of NaBu on the production of recombinant human prolactin (hPRL) from CHO cells was investigated for the first time. sethoxydim 23-27 prolactin Homo sapiens 78-82 20625486-4 2010 Quantitative and qualitative analyses by reverse-phase high-performance liquid chromatography (RP-HPLC) and Western blot or SDS-PAGE, carried out directly on CHO-conditioned medium, showed that the highest hPRL expression was obtained with 1 mM NaBu. sethoxydim 245-249 prolactin Homo sapiens 206-210 20625486-7 2010 Our results show that NaBu increased the synthesis of recombinant hPRL in CHO cells, apparently without compromising either its structure or function. sethoxydim 22-26 prolactin Homo sapiens 66-70 19689470-9 2009 VPA and NaBu activated the transcription of p21(CIP1/WAF1) by increasing the acetylation of histone H3 and H4 and eventually blocked the cell cycle at G2/M phase. sethoxydim 8-12 cyclin dependent kinase inhibitor 1A Homo sapiens 44-47 19689470-9 2009 VPA and NaBu activated the transcription of p21(CIP1/WAF1) by increasing the acetylation of histone H3 and H4 and eventually blocked the cell cycle at G2/M phase. sethoxydim 8-12 cyclin dependent kinase inhibitor 1A Homo sapiens 48-52 19689470-9 2009 VPA and NaBu activated the transcription of p21(CIP1/WAF1) by increasing the acetylation of histone H3 and H4 and eventually blocked the cell cycle at G2/M phase. sethoxydim 8-12 cyclin dependent kinase inhibitor 1A Homo sapiens 53-57 19427965-5 2009 RESULTS: We found that 5-dAzaC, TSA, and NaBu lead to an increase in GRalpha and ASF/SF2 transcript levels and a decrease in GRbeta transcript levels in HT-29 and MCF-7 cells. sethoxydim 41-45 serine and arginine rich splicing factor 1 Homo sapiens 81-88 19427965-6 2009 The 5-dAzaC, TSA, and NaBu resulted in increased GRalpha and ASF/SF2 protein levels and GRbeta protein downregulation in HT-29 cells. sethoxydim 22-26 serine and arginine rich splicing factor 1 Homo sapiens 61-68 19427965-9 2009 The MCF-7 cells treated with NaBu demonstrated a remarkable increase in ASF/SF2 protein expression. sethoxydim 29-33 serine and arginine rich splicing factor 1 Homo sapiens 72-79 18642058-2 2008 Here we show that both p18( INK4C ) mRNA and protein levels were upregulated during K562 cell erythroid differentiation induced by NaBu. sethoxydim 131-135 cyclin dependent kinase inhibitor 2C Homo sapiens 23-26 18642058-2 2008 Here we show that both p18( INK4C ) mRNA and protein levels were upregulated during K562 cell erythroid differentiation induced by NaBu. sethoxydim 131-135 cyclin dependent kinase inhibitor 2C Homo sapiens 28-33 18642058-3 2008 Moreover, the NaBu activation of p18( INK4C ) was dependent on the integrity of Sp1 clusters in the promoter. sethoxydim 14-18 cyclin dependent kinase inhibitor 2C Homo sapiens 33-36 18642058-3 2008 Moreover, the NaBu activation of p18( INK4C ) was dependent on the integrity of Sp1 clusters in the promoter. sethoxydim 14-18 cyclin dependent kinase inhibitor 2C Homo sapiens 38-43 18642058-4 2008 NaBu caused hyperacetylation of histones H3 and H4 on endogenous p18( INK4C ) promoter and enhanced binding of transcription factor Sp1 in vivo. sethoxydim 0-4 cyclin dependent kinase inhibitor 2C Homo sapiens 65-68 18642058-4 2008 NaBu caused hyperacetylation of histones H3 and H4 on endogenous p18( INK4C ) promoter and enhanced binding of transcription factor Sp1 in vivo. sethoxydim 0-4 cyclin dependent kinase inhibitor 2C Homo sapiens 70-75 18642058-6 2008 Our results suggested that NaBu-mediated p18( INK4C ) regulation played a role in cell cycle arrest and erythroid differentiation in K562 cells. sethoxydim 27-31 cyclin dependent kinase inhibitor 2C Homo sapiens 41-44 18642058-6 2008 Our results suggested that NaBu-mediated p18( INK4C ) regulation played a role in cell cycle arrest and erythroid differentiation in K562 cells. sethoxydim 27-31 cyclin dependent kinase inhibitor 2C Homo sapiens 46-51 18164778-1 2008 Sodium butyrate (NaBu) is known to enhance the specific productivity of Chinese hamster ovary cells expressing human thrombopoietin. sethoxydim 17-21 thrombopoietin Homo sapiens 117-131 18164778-5 2008 Compared to control without NaBu treatment, the expression levels of 2 proteins (glucose regulated protein 78 (GRP 78) and peroxiredoxin 4) were increased over two fold with NaBu treatment and the expression level of phosphopyruvate hydratase was decreased over two fold with NaBu treatment. sethoxydim 28-32 endoplasmic reticulum chaperone BiP Cricetulus griseus 81-109 18164778-5 2008 Compared to control without NaBu treatment, the expression levels of 2 proteins (glucose regulated protein 78 (GRP 78) and peroxiredoxin 4) were increased over two fold with NaBu treatment and the expression level of phosphopyruvate hydratase was decreased over two fold with NaBu treatment. sethoxydim 28-32 endoplasmic reticulum chaperone BiP Cricetulus griseus 111-117 18164778-5 2008 Compared to control without NaBu treatment, the expression levels of 2 proteins (glucose regulated protein 78 (GRP 78) and peroxiredoxin 4) were increased over two fold with NaBu treatment and the expression level of phosphopyruvate hydratase was decreased over two fold with NaBu treatment. sethoxydim 28-32 peroxiredoxin-4 Cricetulus griseus 123-138 18164778-5 2008 Compared to control without NaBu treatment, the expression levels of 2 proteins (glucose regulated protein 78 (GRP 78) and peroxiredoxin 4) were increased over two fold with NaBu treatment and the expression level of phosphopyruvate hydratase was decreased over two fold with NaBu treatment. sethoxydim 174-178 endoplasmic reticulum chaperone BiP Cricetulus griseus 81-109 18164778-5 2008 Compared to control without NaBu treatment, the expression levels of 2 proteins (glucose regulated protein 78 (GRP 78) and peroxiredoxin 4) were increased over two fold with NaBu treatment and the expression level of phosphopyruvate hydratase was decreased over two fold with NaBu treatment. sethoxydim 174-178 endoplasmic reticulum chaperone BiP Cricetulus griseus 111-117 18164778-5 2008 Compared to control without NaBu treatment, the expression levels of 2 proteins (glucose regulated protein 78 (GRP 78) and peroxiredoxin 4) were increased over two fold with NaBu treatment and the expression level of phosphopyruvate hydratase was decreased over two fold with NaBu treatment. sethoxydim 174-178 peroxiredoxin-4 Cricetulus griseus 123-138 18164778-5 2008 Compared to control without NaBu treatment, the expression levels of 2 proteins (glucose regulated protein 78 (GRP 78) and peroxiredoxin 4) were increased over two fold with NaBu treatment and the expression level of phosphopyruvate hydratase was decreased over two fold with NaBu treatment. sethoxydim 174-178 endoplasmic reticulum chaperone BiP Cricetulus griseus 81-109 18164778-5 2008 Compared to control without NaBu treatment, the expression levels of 2 proteins (glucose regulated protein 78 (GRP 78) and peroxiredoxin 4) were increased over two fold with NaBu treatment and the expression level of phosphopyruvate hydratase was decreased over two fold with NaBu treatment. sethoxydim 174-178 endoplasmic reticulum chaperone BiP Cricetulus griseus 111-117 18164778-5 2008 Compared to control without NaBu treatment, the expression levels of 2 proteins (glucose regulated protein 78 (GRP 78) and peroxiredoxin 4) were increased over two fold with NaBu treatment and the expression level of phosphopyruvate hydratase was decreased over two fold with NaBu treatment. sethoxydim 174-178 peroxiredoxin-4 Cricetulus griseus 123-138 17892962-3 2007 For the successful inhibition of NaBu-induced apoptosis of rCHO cells, both caspase-3 and caspase-7 were down-regulated using the siRNA expression vector system. sethoxydim 33-37 caspase 3 Rattus norvegicus 76-85 17892962-3 2007 For the successful inhibition of NaBu-induced apoptosis of rCHO cells, both caspase-3 and caspase-7 were down-regulated using the siRNA expression vector system. sethoxydim 33-37 caspase 7 Rattus norvegicus 90-99 17892962-4 2007 Co-down-regulation of caspase-3 and caspase-7 increased cell viability and extended culture longevity in serum-free culture in the presence or absence of 1mM NaBu addition. sethoxydim 158-162 caspase 3 Rattus norvegicus 22-31 17892962-4 2007 Co-down-regulation of caspase-3 and caspase-7 increased cell viability and extended culture longevity in serum-free culture in the presence or absence of 1mM NaBu addition. sethoxydim 158-162 caspase 7 Rattus norvegicus 36-45 17892962-5 2007 In the cultures with 1mM NaBu addition, the maximum hTPO concentration in rCHO cells with down-regulation of both caspases was approximately 55% higher than that in rCHO cells without down-regulation of caspases and approximately 16% higher than rCHO cells with down-regulation of only caspase-3. sethoxydim 25-29 thyroid peroxidase Homo sapiens 52-56 17892962-5 2007 In the cultures with 1mM NaBu addition, the maximum hTPO concentration in rCHO cells with down-regulation of both caspases was approximately 55% higher than that in rCHO cells without down-regulation of caspases and approximately 16% higher than rCHO cells with down-regulation of only caspase-3. sethoxydim 25-29 caspase 3 Rattus norvegicus 286-295 17892962-7 2007 The different result in hTPO production between down-regulation of caspases and Bcl-2 overexpression may be because the down-regulation of caspase-3 and caspase-7, unlike Bcl-2 overexpression, could not maintain mitochondrial membrane potential in the presence of 3mM NaBu. sethoxydim 268-272 thyroid peroxidase Homo sapiens 24-28 17892962-7 2007 The different result in hTPO production between down-regulation of caspases and Bcl-2 overexpression may be because the down-regulation of caspase-3 and caspase-7, unlike Bcl-2 overexpression, could not maintain mitochondrial membrane potential in the presence of 3mM NaBu. sethoxydim 268-272 BCL2, apoptosis regulator Rattus norvegicus 80-85 17892962-8 2007 Taken together, co-down-regulation of caspase-3 and caspase-7 is effective in regard to extension of culture longevity and enhancement of hTPO production in a serum-free culture in the presence or absence of 1mM NaBu addition. sethoxydim 212-216 caspase 3 Rattus norvegicus 38-47 17892962-8 2007 Taken together, co-down-regulation of caspase-3 and caspase-7 is effective in regard to extension of culture longevity and enhancement of hTPO production in a serum-free culture in the presence or absence of 1mM NaBu addition. sethoxydim 212-216 caspase 7 Rattus norvegicus 52-61 17595767-7 2007 NaBu also regulated COX-2 and sPLA2-X expression, and augmented PGE2 synthesis in OCC. sethoxydim 0-4 mitochondrially encoded cytochrome c oxidase II Homo sapiens 20-25 17595767-7 2007 NaBu also regulated COX-2 and sPLA2-X expression, and augmented PGE2 synthesis in OCC. sethoxydim 0-4 phospholipase A2 group X Homo sapiens 30-37 17417942-4 2007 While NaBu significantly increased the IL-1beta -induction of genes like SAA2, C3, and IL-1alpha , other inflammatory genes like CXCL5, CXCL11, and IL-1beta were decreased. sethoxydim 6-10 interleukin 1 beta Homo sapiens 39-47 17417942-4 2007 While NaBu significantly increased the IL-1beta -induction of genes like SAA2, C3, and IL-1alpha , other inflammatory genes like CXCL5, CXCL11, and IL-1beta were decreased. sethoxydim 6-10 serum amyloid A2 Homo sapiens 73-77 17417942-4 2007 While NaBu significantly increased the IL-1beta -induction of genes like SAA2, C3, and IL-1alpha , other inflammatory genes like CXCL5, CXCL11, and IL-1beta were decreased. sethoxydim 6-10 interleukin 1 alpha Homo sapiens 87-96 17417942-7 2007 In addition, transient treatment with IL-1beta was sufficient for subsequent induction of NaBu-upregulated and NaBu-unaffected classes of genes, while a continuous presence of IL-1beta was required for NaBu-downregulated gene expression. sethoxydim 90-94 interleukin 1 beta Homo sapiens 38-46 17417942-7 2007 In addition, transient treatment with IL-1beta was sufficient for subsequent induction of NaBu-upregulated and NaBu-unaffected classes of genes, while a continuous presence of IL-1beta was required for NaBu-downregulated gene expression. sethoxydim 111-115 interleukin 1 beta Homo sapiens 38-46 17417942-7 2007 In addition, transient treatment with IL-1beta was sufficient for subsequent induction of NaBu-upregulated and NaBu-unaffected classes of genes, while a continuous presence of IL-1beta was required for NaBu-downregulated gene expression. sethoxydim 111-115 interleukin 1 beta Homo sapiens 38-46 16337085-7 2006 TSA and NaBu exerted differential preventive effects on the H(2)O(2) and TPA-induced inhibition of GJIC as well as hyperphosphorylation of connexin43 (Cx43) in WB-F344 rat liver epithelial cells (WB cells). sethoxydim 8-12 gap junction protein, alpha 1 Rattus norvegicus 139-149 17233117-3 2006 Sodium butyrate (NaBu), a short-chain fatty acid and histone deacetylase (HDAC) inhibitor, was used to induce IAP expression in HT-29 cells and the cells were also treated +/- the cytokines. sethoxydim 17-21 alkaline phosphatase, intestinal Homo sapiens 110-113 17233117-4 2006 Northern blots confirmed IAP induction by NaBu, however, pretreatment (6 h) with either cytokine showed a dose-dependent inhibition of IAP expression. sethoxydim 42-46 alkaline phosphatase, intestinal Homo sapiens 25-28 17233117-6 2006 Transient transfections with a reporter plasmid carrying the human IAP promoter showed significant inhibition of NaBu-induced IAP gene activation by the cytokines (100 and 60% inhibition with IL-1beta and TNF-alpha, respectively). sethoxydim 113-117 alkaline phosphatase, intestinal Homo sapiens 67-70 17233117-6 2006 Transient transfections with a reporter plasmid carrying the human IAP promoter showed significant inhibition of NaBu-induced IAP gene activation by the cytokines (100 and 60% inhibition with IL-1beta and TNF-alpha, respectively). sethoxydim 113-117 alkaline phosphatase, intestinal Homo sapiens 126-129 17233117-6 2006 Transient transfections with a reporter plasmid carrying the human IAP promoter showed significant inhibition of NaBu-induced IAP gene activation by the cytokines (100 and 60% inhibition with IL-1beta and TNF-alpha, respectively). sethoxydim 113-117 interleukin 1 beta Homo sapiens 192-200 17233117-6 2006 Transient transfections with a reporter plasmid carrying the human IAP promoter showed significant inhibition of NaBu-induced IAP gene activation by the cytokines (100 and 60% inhibition with IL-1beta and TNF-alpha, respectively). sethoxydim 113-117 tumor necrosis factor Homo sapiens 205-214 17233117-9 2006 We conclude that IL-1beta and TNF-alpha inhibit NaBu-induced IAP gene expression, likely by blocking the histone acetylation within its promoter. sethoxydim 48-52 interleukin 1 beta Homo sapiens 17-25 17233117-9 2006 We conclude that IL-1beta and TNF-alpha inhibit NaBu-induced IAP gene expression, likely by blocking the histone acetylation within its promoter. sethoxydim 48-52 tumor necrosis factor Homo sapiens 30-39 17233117-9 2006 We conclude that IL-1beta and TNF-alpha inhibit NaBu-induced IAP gene expression, likely by blocking the histone acetylation within its promoter. sethoxydim 48-52 alkaline phosphatase, intestinal Homo sapiens 61-64 16337085-9 2006 The inhibition of tyrosine phosphorylation and down-regulation of src protein observed may also contribute to Connexin 43 dephosphorylation and GJIC restoration by TSA and NaBu partly through depletion of src protein pool. sethoxydim 172-176 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 66-69 16337085-9 2006 The inhibition of tyrosine phosphorylation and down-regulation of src protein observed may also contribute to Connexin 43 dephosphorylation and GJIC restoration by TSA and NaBu partly through depletion of src protein pool. sethoxydim 172-176 gap junction protein, alpha 1 Rattus norvegicus 110-121 16337085-9 2006 The inhibition of tyrosine phosphorylation and down-regulation of src protein observed may also contribute to Connexin 43 dephosphorylation and GJIC restoration by TSA and NaBu partly through depletion of src protein pool. sethoxydim 172-176 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 205-208 17270283-2 2007 We report here that inhibition of HDAC activity by Trichostatin A (TSA) and sodium butyrate (NaBu), the two specific HDAC inhibitors, resulted in the elevation of both endogenous and exogenous activity of IL-5 promoter. sethoxydim 93-97 interleukin 5 Homo sapiens 205-209 17270283-3 2007 We demonstrated that both the mRNA expression and protein production of IL-5 were stimulated by TSA and NaBu treatments. sethoxydim 104-108 interleukin 5 Homo sapiens 72-76 17270283-4 2007 ChIP assays showed that treatments of TSA and NaBu caused hyperacetylation of histones H3 and H4 on IL-5 promoter in Jurkat cells, which consequently promoted the exogenous luciferase activity driven by this promoter. sethoxydim 46-50 interleukin 5 Homo sapiens 100-104 17270283-5 2007 Moreover, site-directed mutagenesis studies showed that the binding sites for transcription factors NFAT, GATA3 and YY1 on IL-5 promoter were critical for the effects of TSA and NaBu, suggesting that the transcriptional activation of IL-5 gene by these inhibitors was achieved by affecting HDAC function on IL-5 promoter via transcription factors. sethoxydim 178-182 GATA binding protein 3 Homo sapiens 106-111 17270283-5 2007 Moreover, site-directed mutagenesis studies showed that the binding sites for transcription factors NFAT, GATA3 and YY1 on IL-5 promoter were critical for the effects of TSA and NaBu, suggesting that the transcriptional activation of IL-5 gene by these inhibitors was achieved by affecting HDAC function on IL-5 promoter via transcription factors. sethoxydim 178-182 YY1 transcription factor Homo sapiens 116-119 17270283-5 2007 Moreover, site-directed mutagenesis studies showed that the binding sites for transcription factors NFAT, GATA3 and YY1 on IL-5 promoter were critical for the effects of TSA and NaBu, suggesting that the transcriptional activation of IL-5 gene by these inhibitors was achieved by affecting HDAC function on IL-5 promoter via transcription factors. sethoxydim 178-182 interleukin 5 Homo sapiens 123-127 17270283-5 2007 Moreover, site-directed mutagenesis studies showed that the binding sites for transcription factors NFAT, GATA3 and YY1 on IL-5 promoter were critical for the effects of TSA and NaBu, suggesting that the transcriptional activation of IL-5 gene by these inhibitors was achieved by affecting HDAC function on IL-5 promoter via transcription factors. sethoxydim 178-182 interleukin 5 Homo sapiens 234-238 17270283-5 2007 Moreover, site-directed mutagenesis studies showed that the binding sites for transcription factors NFAT, GATA3 and YY1 on IL-5 promoter were critical for the effects of TSA and NaBu, suggesting that the transcriptional activation of IL-5 gene by these inhibitors was achieved by affecting HDAC function on IL-5 promoter via transcription factors. sethoxydim 178-182 interleukin 5 Homo sapiens 234-238 16337085-7 2006 TSA and NaBu exerted differential preventive effects on the H(2)O(2) and TPA-induced inhibition of GJIC as well as hyperphosphorylation of connexin43 (Cx43) in WB-F344 rat liver epithelial cells (WB cells). sethoxydim 8-12 gap junction protein, alpha 1 Rattus norvegicus 151-155 16337085-8 2006 NaBu prevented the TPA-induced GJIC inhibition via ERK1/2 inactivation whilst TSA restored the H(2)O(2)-induced GJIC inhibition and Cx43 hyperphosphorylation by preventing p38 MAP kinase. sethoxydim 0-4 mitogen activated protein kinase 3 Rattus norvegicus 51-57 16374231-6 2006 In addition, NaBu induced caspase-3 and poly-ADP ribose polymerase cleavage and up-regulation of bax, suggesting that mitochondrial damage is involved in NaBu-induced caspase-dependent apoptosis. sethoxydim 13-17 caspase 3 Homo sapiens 26-35 16374231-6 2006 In addition, NaBu induced caspase-3 and poly-ADP ribose polymerase cleavage and up-regulation of bax, suggesting that mitochondrial damage is involved in NaBu-induced caspase-dependent apoptosis. sethoxydim 13-17 poly(ADP-ribose) polymerase 1 Homo sapiens 40-66 16374231-7 2006 Interestingly, NaBu stimulated p38 mitogen-activated protein kinase (MAPK) and c-Jun NH2-terminal kinase (JNK) activation, but not extracellular signal-regulated kinase 1/2 activation during apoptosis. sethoxydim 15-19 mitogen-activated protein kinase 14 Homo sapiens 31-67 16374231-7 2006 Interestingly, NaBu stimulated p38 mitogen-activated protein kinase (MAPK) and c-Jun NH2-terminal kinase (JNK) activation, but not extracellular signal-regulated kinase 1/2 activation during apoptosis. sethoxydim 15-19 mitogen-activated protein kinase 3 Homo sapiens 69-73 16374231-7 2006 Interestingly, NaBu stimulated p38 mitogen-activated protein kinase (MAPK) and c-Jun NH2-terminal kinase (JNK) activation, but not extracellular signal-regulated kinase 1/2 activation during apoptosis. sethoxydim 15-19 mitogen-activated protein kinase 8 Homo sapiens 79-104 16374231-7 2006 Interestingly, NaBu stimulated p38 mitogen-activated protein kinase (MAPK) and c-Jun NH2-terminal kinase (JNK) activation, but not extracellular signal-regulated kinase 1/2 activation during apoptosis. sethoxydim 15-19 mitogen-activated protein kinase 8 Homo sapiens 106-109 16374231-8 2006 Furthermore, NaBu up-regulated total protein levels and phospho forms of MAPK kinase 3 (MKK3) and MAPK kinase 4 (MKK4) as the upstream kinases of p38 MAPK and JNK independently of oxidative stress. sethoxydim 13-17 mitogen-activated protein kinase kinase 3 Homo sapiens 73-86 16374231-8 2006 Furthermore, NaBu up-regulated total protein levels and phospho forms of MAPK kinase 3 (MKK3) and MAPK kinase 4 (MKK4) as the upstream kinases of p38 MAPK and JNK independently of oxidative stress. sethoxydim 13-17 mitogen-activated protein kinase kinase 3 Homo sapiens 88-92 16374231-8 2006 Furthermore, NaBu up-regulated total protein levels and phospho forms of MAPK kinase 3 (MKK3) and MAPK kinase 4 (MKK4) as the upstream kinases of p38 MAPK and JNK independently of oxidative stress. sethoxydim 13-17 mitogen-activated protein kinase kinase 4 Homo sapiens 98-111 16374231-8 2006 Furthermore, NaBu up-regulated total protein levels and phospho forms of MAPK kinase 3 (MKK3) and MAPK kinase 4 (MKK4) as the upstream kinases of p38 MAPK and JNK independently of oxidative stress. sethoxydim 13-17 mitogen-activated protein kinase kinase 4 Homo sapiens 113-117 16374231-8 2006 Furthermore, NaBu up-regulated total protein levels and phospho forms of MAPK kinase 3 (MKK3) and MAPK kinase 4 (MKK4) as the upstream kinases of p38 MAPK and JNK independently of oxidative stress. sethoxydim 13-17 mitogen-activated protein kinase 14 Homo sapiens 146-149 16374231-8 2006 Furthermore, NaBu up-regulated total protein levels and phospho forms of MAPK kinase 3 (MKK3) and MAPK kinase 4 (MKK4) as the upstream kinases of p38 MAPK and JNK independently of oxidative stress. sethoxydim 13-17 mitogen-activated protein kinase 3 Homo sapiens 73-77 16374231-8 2006 Furthermore, NaBu up-regulated total protein levels and phospho forms of MAPK kinase 3 (MKK3) and MAPK kinase 4 (MKK4) as the upstream kinases of p38 MAPK and JNK independently of oxidative stress. sethoxydim 13-17 mitogen-activated protein kinase 8 Homo sapiens 159-162 16374231-9 2006 Taken together, it is suggested that NaBu can be a promising chemopreventive agent for prostate cancer and the p38 MAPK and JNK pathways have critical roles in NaBu-induced apoptosis in DU145 cells. sethoxydim 160-164 mitogen-activated protein kinase 14 Homo sapiens 111-114 16374231-9 2006 Taken together, it is suggested that NaBu can be a promising chemopreventive agent for prostate cancer and the p38 MAPK and JNK pathways have critical roles in NaBu-induced apoptosis in DU145 cells. sethoxydim 160-164 mitogen-activated protein kinase 3 Homo sapiens 115-119 16374231-9 2006 Taken together, it is suggested that NaBu can be a promising chemopreventive agent for prostate cancer and the p38 MAPK and JNK pathways have critical roles in NaBu-induced apoptosis in DU145 cells. sethoxydim 160-164 mitogen-activated protein kinase 8 Homo sapiens 124-127 16270534-2 2005 The effects of chromatin structure on gene expression and the use of histone deacetylase inhibitors such as sodium butyrate (NaBu) may directly influence pro-MMPs secretion. sethoxydim 125-129 matrix metallopeptidase 2 Homo sapiens 158-162 16968879-0 2006 Sethoxydim affects lipid synthesis and acetyl-CoA carboxylase activity in soybean. sethoxydim 0-10 acetyl-CoA carboxylase 1 Glycine max 39-61 16968879-2 2006 The sensitivity of most monocots to cyclohexanediones (CHDs) such as sethoxydim, has been shown to be associated with the presence in their plastids of a multifunctional (eukaryotic) form of ACCase. sethoxydim 69-79 acetyl-CoA carboxylase 1 Glycine max 191-197 16968879-7 2006 ACCase activity of soybean plastidial preparations was 60% reduced in the presence of sethoxydim, whereas that of N. sylvestris was unaffected. sethoxydim 86-96 acetyl-CoA carboxylase 1 Glycine max 0-6 16356138-2 2005 The mitogen-activated protein (MAP) kinases, such as extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 MAP, kinase are known to be modulated during NaBu-induced apoptosis. sethoxydim 157-161 mitogen activated protein kinase 3 Rattus norvegicus 53-94 16356138-2 2005 The mitogen-activated protein (MAP) kinases, such as extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 MAP, kinase are known to be modulated during NaBu-induced apoptosis. sethoxydim 157-161 mitogen activated protein kinase 3 Rattus norvegicus 96-102 16356138-2 2005 The mitogen-activated protein (MAP) kinases, such as extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 MAP, kinase are known to be modulated during NaBu-induced apoptosis. sethoxydim 157-161 mitogen activated protein kinase 14 Rattus norvegicus 108-111 16356138-3 2005 In the present study, we showed that low concentrations of NaBu could induce apoptosis synergistically with the inhibition of p38 MAP kinase as proven by using specific p38 MAP kinase inhibitor and dominant negative p38 transfection in a ras-transformed rat liver epithelial cell line (WB-ras). sethoxydim 59-63 mitogen activated protein kinase 14 Rattus norvegicus 126-129 16356138-3 2005 In the present study, we showed that low concentrations of NaBu could induce apoptosis synergistically with the inhibition of p38 MAP kinase as proven by using specific p38 MAP kinase inhibitor and dominant negative p38 transfection in a ras-transformed rat liver epithelial cell line (WB-ras). sethoxydim 59-63 mitogen activated protein kinase 14 Rattus norvegicus 126-140 16356138-3 2005 In the present study, we showed that low concentrations of NaBu could induce apoptosis synergistically with the inhibition of p38 MAP kinase as proven by using specific p38 MAP kinase inhibitor and dominant negative p38 transfection in a ras-transformed rat liver epithelial cell line (WB-ras). sethoxydim 59-63 mitogen activated protein kinase 14 Rattus norvegicus 169-172 16356138-5 2005 We further demonstrated that inhibition of p38 MAP kinase potentiated apoptotic cascades, including cleavage of poly(ADP-ribose) polymerase, caspase-3, and decrease in Bcl-2/Bax ratio even at a lower concentration of NaBu. sethoxydim 217-221 mitogen activated protein kinase 14 Rattus norvegicus 43-46 16356138-5 2005 We further demonstrated that inhibition of p38 MAP kinase potentiated apoptotic cascades, including cleavage of poly(ADP-ribose) polymerase, caspase-3, and decrease in Bcl-2/Bax ratio even at a lower concentration of NaBu. sethoxydim 217-221 poly (ADP-ribose) polymerase 1 Rattus norvegicus 112-139 16356138-6 2005 Thus, p38 MAP kinase played inhibitory roles in NaBu-induced apoptosis, and simultaneous modulation of MAP kinases in NaBu treatment could increase the efficiency of the chemotherapeutic effect of NaBu. sethoxydim 48-52 mitogen activated protein kinase 14 Rattus norvegicus 6-9 16270534-5 2005 Our results showed, for Jurkat cells treated with NaBu, increases of 2-fold and 1.5-fold in pro-MMP-9 and pro-MMP-2 secretion, respectively. sethoxydim 50-54 matrix metallopeptidase 2 Homo sapiens 110-115 15812237-2 2005 In this study, we showed by Northern blot a synergistic induction of the acute phase protein gene SAA2 with a combination of deacetylase inhibitors (Trichostatin A or NaBu) and IL-1beta in the colon carcinoma cell line Caco-2. sethoxydim 167-171 serum amyloid A2 Homo sapiens 98-102 16169764-5 2005 Under the condition of 1-5 mM NaBu addition at the exponential growth phase, down-regulation of caspase-3 in F21 cells could not effectively inhibit NaBu-induced apoptotic cell death. sethoxydim 30-34 caspase 3 Rattus norvegicus 96-105 16169764-6 2005 This NaBu-induced apoptotic cell death occurred because F21 cells appeared to compensate for the lack of caspase-3 by increasing the active caspase-7 level. sethoxydim 5-9 caspase 3 Rattus norvegicus 105-114 16169764-6 2005 This NaBu-induced apoptotic cell death occurred because F21 cells appeared to compensate for the lack of caspase-3 by increasing the active caspase-7 level. sethoxydim 5-9 caspase 7 Rattus norvegicus 140-149 15978324-7 2005 Thus, ras/ERK signaling pathway can be considered in chemotherapeutic strategies of NaBu regardless of its inhibitory action on histone deacetylase. sethoxydim 84-88 Eph receptor B1 Rattus norvegicus 10-13 15812237-4 2005 NaBu was sufficient to induce SAA2 expression after transient treatment with IL-1beta and, conversely, IL-1beta induced SAA2 after transient treatment with NaBu. sethoxydim 0-4 serum amyloid A2 Homo sapiens 30-34 15812237-4 2005 NaBu was sufficient to induce SAA2 expression after transient treatment with IL-1beta and, conversely, IL-1beta induced SAA2 after transient treatment with NaBu. sethoxydim 0-4 interleukin 1 beta Homo sapiens 77-85 15812237-4 2005 NaBu was sufficient to induce SAA2 expression after transient treatment with IL-1beta and, conversely, IL-1beta induced SAA2 after transient treatment with NaBu. sethoxydim 156-160 interleukin 1 beta Homo sapiens 103-111 15812237-4 2005 NaBu was sufficient to induce SAA2 expression after transient treatment with IL-1beta and, conversely, IL-1beta induced SAA2 after transient treatment with NaBu. sethoxydim 156-160 serum amyloid A2 Homo sapiens 120-124 15812237-5 2005 These data suggest that pretreatment with either NaBu or IL-1beta predisposes the SAA2 promoter to further stimulation. sethoxydim 49-53 serum amyloid A2 Homo sapiens 82-86 15812237-6 2005 Indeed, both NaBu and IL-1beta led to increased recruitment of NF-kappa B p65, C/EBPbeta, and C/EBP delta, and decreased NF-kappa B p50 and C/EBP alpha DNA-binding to the proximal SAA2 promoter, as assessed by chromatin immunoprecipitation assays. sethoxydim 13-17 nuclear factor kappa B subunit 1 Homo sapiens 63-73 15812237-6 2005 Indeed, both NaBu and IL-1beta led to increased recruitment of NF-kappa B p65, C/EBPbeta, and C/EBP delta, and decreased NF-kappa B p50 and C/EBP alpha DNA-binding to the proximal SAA2 promoter, as assessed by chromatin immunoprecipitation assays. sethoxydim 13-17 RELA proto-oncogene, NF-kB subunit Homo sapiens 74-77 15812237-6 2005 Indeed, both NaBu and IL-1beta led to increased recruitment of NF-kappa B p65, C/EBPbeta, and C/EBP delta, and decreased NF-kappa B p50 and C/EBP alpha DNA-binding to the proximal SAA2 promoter, as assessed by chromatin immunoprecipitation assays. sethoxydim 13-17 CCAAT enhancer binding protein beta Homo sapiens 79-88 15812237-6 2005 Indeed, both NaBu and IL-1beta led to increased recruitment of NF-kappa B p65, C/EBPbeta, and C/EBP delta, and decreased NF-kappa B p50 and C/EBP alpha DNA-binding to the proximal SAA2 promoter, as assessed by chromatin immunoprecipitation assays. sethoxydim 13-17 CCAAT enhancer binding protein delta Homo sapiens 94-105 15812237-6 2005 Indeed, both NaBu and IL-1beta led to increased recruitment of NF-kappa B p65, C/EBPbeta, and C/EBP delta, and decreased NF-kappa B p50 and C/EBP alpha DNA-binding to the proximal SAA2 promoter, as assessed by chromatin immunoprecipitation assays. sethoxydim 13-17 nuclear factor kappa B subunit 1 Homo sapiens 121-131 15812237-6 2005 Indeed, both NaBu and IL-1beta led to increased recruitment of NF-kappa B p65, C/EBPbeta, and C/EBP delta, and decreased NF-kappa B p50 and C/EBP alpha DNA-binding to the proximal SAA2 promoter, as assessed by chromatin immunoprecipitation assays. sethoxydim 13-17 nuclear factor kappa B subunit 1 Homo sapiens 132-135 15812237-6 2005 Indeed, both NaBu and IL-1beta led to increased recruitment of NF-kappa B p65, C/EBPbeta, and C/EBP delta, and decreased NF-kappa B p50 and C/EBP alpha DNA-binding to the proximal SAA2 promoter, as assessed by chromatin immunoprecipitation assays. sethoxydim 13-17 CCAAT enhancer binding protein alpha Homo sapiens 140-151 15812237-6 2005 Indeed, both NaBu and IL-1beta led to increased recruitment of NF-kappa B p65, C/EBPbeta, and C/EBP delta, and decreased NF-kappa B p50 and C/EBP alpha DNA-binding to the proximal SAA2 promoter, as assessed by chromatin immunoprecipitation assays. sethoxydim 13-17 serum amyloid A2 Homo sapiens 180-184 15812237-7 2005 Interestingly, while IL-1beta, in contrast to NaBu, induced histone H4 acetylation, addition of IL-1beta and NaBu increased histone H4 acetylation and both C/EBPbeta and NF-kappa B p65 DNA-binding. sethoxydim 109-113 CCAAT enhancer binding protein beta Homo sapiens 156-165 15812237-7 2005 Interestingly, while IL-1beta, in contrast to NaBu, induced histone H4 acetylation, addition of IL-1beta and NaBu increased histone H4 acetylation and both C/EBPbeta and NF-kappa B p65 DNA-binding. sethoxydim 109-113 nuclear factor kappa B subunit 1 Homo sapiens 170-182 15812237-8 2005 Therefore, these results suggest that NaBu and IL- 1beta mediate SAA2 synergistic induction by establishing and maintaining similar and complementary chromatin modifications and transcription factor recruitment as well. sethoxydim 38-42 serum amyloid A2 Homo sapiens 65-69 15547708-8 2004 Furthermore, bax mRNA level was up-regulated whereas a decline in Bcl-2 both protein and mRNA levels were detected in NaBu-treated cells. sethoxydim 118-122 BCL2 associated X, apoptosis regulator Homo sapiens 13-16 15903240-1 2005 When sodium butyrate (NaBu) was added to serum-free suspension culture of recombinant CHO (rCHO) cells for enhanced expression of human thrombopoietin (hTPO), apoptotic cell death of rCHO cells was induced in a dose-dependent manner and hTPO quality was deteriorated in regard to sialic acid and acidic isoform contents. sethoxydim 22-26 thrombopoietin Homo sapiens 136-150 15903240-1 2005 When sodium butyrate (NaBu) was added to serum-free suspension culture of recombinant CHO (rCHO) cells for enhanced expression of human thrombopoietin (hTPO), apoptotic cell death of rCHO cells was induced in a dose-dependent manner and hTPO quality was deteriorated in regard to sialic acid and acidic isoform contents. sethoxydim 22-26 thyroid peroxidase Homo sapiens 152-156 15903240-1 2005 When sodium butyrate (NaBu) was added to serum-free suspension culture of recombinant CHO (rCHO) cells for enhanced expression of human thrombopoietin (hTPO), apoptotic cell death of rCHO cells was induced in a dose-dependent manner and hTPO quality was deteriorated in regard to sialic acid and acidic isoform contents. sethoxydim 22-26 thyroid peroxidase Homo sapiens 237-241 15903240-3 2005 Compared to serum-free suspension culture of control cells without Bcl-2 overexpression (R-neo cells) and NaBu addition, a more than 10-fold increase in the maximum hTPO concentration was obtained in serum-free suspension culture of cells with Bcl-2 overexpression (R-bc12-14 cells) and 3 mM NaBu addition. sethoxydim 106-110 thyroid peroxidase Homo sapiens 165-169 15903240-3 2005 Compared to serum-free suspension culture of control cells without Bcl-2 overexpression (R-neo cells) and NaBu addition, a more than 10-fold increase in the maximum hTPO concentration was obtained in serum-free suspension culture of cells with Bcl-2 overexpression (R-bc12-14 cells) and 3 mM NaBu addition. sethoxydim 292-296 thyroid peroxidase Homo sapiens 165-169 15903240-3 2005 Compared to serum-free suspension culture of control cells without Bcl-2 overexpression (R-neo cells) and NaBu addition, a more than 10-fold increase in the maximum hTPO concentration was obtained in serum-free suspension culture of cells with Bcl-2 overexpression (R-bc12-14 cells) and 3 mM NaBu addition. sethoxydim 292-296 BCL2, apoptosis regulator Rattus norvegicus 244-249 15903240-4 2005 Both the enhanced specific productivity endowed by NaBu and the extended culture longevity provided by the antiapoptotic effect of Bcl-2 overexpression contributed to the enhancement of maximum hTPO concentration. sethoxydim 51-55 thyroid peroxidase Homo sapiens 194-198 15903240-5 2005 The problem of quality reduction of hTPO induced by NaBu was not solved by Bcl-2 overexpression, but it was not that significant. sethoxydim 52-56 thyroid peroxidase Homo sapiens 36-40 15903240-7 2005 As a result, a more than 6-fold increase in the production of hTPO isoforms in pI 3-5 was achieved in R-bcl2-14 cell culture with 3 mM NaBu addition. sethoxydim 135-139 thyroid peroxidase Homo sapiens 62-66 15903240-8 2005 Taken together, the data obtained suggest that Bcl-2 overexpression in rCHO cells and NaBu addition in serum-free suspension culture can be an effective means to enhance the production of highly glycosylated protein such as hTPO. sethoxydim 86-90 thyroid peroxidase Homo sapiens 224-228 15547708-8 2004 Furthermore, bax mRNA level was up-regulated whereas a decline in Bcl-2 both protein and mRNA levels were detected in NaBu-treated cells. sethoxydim 118-122 BCL2 apoptosis regulator Homo sapiens 66-71 15547708-9 2004 Apoptosis was observed following a treatment with 2 mM NaBu, reflected by Annexin-V staining and by the cleavage of poly(ADP-ribose) polymerase, whereas DNA laddering was absent. sethoxydim 55-59 annexin A5 Homo sapiens 74-83 15547708-9 2004 Apoptosis was observed following a treatment with 2 mM NaBu, reflected by Annexin-V staining and by the cleavage of poly(ADP-ribose) polymerase, whereas DNA laddering was absent. sethoxydim 55-59 poly(ADP-ribose) polymerase 1 Homo sapiens 116-143 15547708-11 2004 Finally, NaBu treatment significantly increased the activities of several antioxidant enzymes, including glutathione reductase, glutathione peroxidase, and catalase. sethoxydim 9-13 glutathione-disulfide reductase Homo sapiens 105-126 15547708-11 2004 Finally, NaBu treatment significantly increased the activities of several antioxidant enzymes, including glutathione reductase, glutathione peroxidase, and catalase. sethoxydim 9-13 catalase Homo sapiens 156-164 15296466-1 2004 A single stressful culture condition induced by hypoosmotic stress (210 mOsm kg(-1)), low culture temperature (32 degrees C), or NaBu addition (1 mM) resulted in a 1.8- to 2.2-fold enhancement of specific erythropoietin (EPO) productivity (qEPO) of recombinant Chinese hamster ovary (rCHO) cells compared to normal culture condition (37 degrees C and 310 mOsm kg(-1)). sethoxydim 129-133 erythropoietin Cricetulus griseus 205-219 15547708-5 2004 Following a 24-h exposure, NaBu-induced cell growth arrest in G2/M phase in a dose-dependent fashion in association with stable expression of CDC25A, a G1-specific regulator of the cell cycle. sethoxydim 27-31 cell division cycle 25A Homo sapiens 142-148 15547708-6 2004 The anti-proliferative effects of NaBu were accompanied by diminished expression of p53. sethoxydim 34-38 tumor protein p53 Homo sapiens 84-87 15547708-7 2004 Similarly, mRNA encoding c-Myc, a well-known regulator of p53, was decreased in NaBu-treated cells, while p21(Waf1/Cip1) mRNA was increased. sethoxydim 80-84 MYC proto-oncogene, bHLH transcription factor Homo sapiens 25-30 15547708-7 2004 Similarly, mRNA encoding c-Myc, a well-known regulator of p53, was decreased in NaBu-treated cells, while p21(Waf1/Cip1) mRNA was increased. sethoxydim 80-84 tumor protein p53 Homo sapiens 58-61 15313009-3 2004 NaBu addition significantly increased both the specific and volumetric hTPO production, although it decreased the cell viability by apoptosis in a dose-dependent manner. sethoxydim 0-4 thyroid peroxidase Homo sapiens 71-75 15313009-4 2004 The highest hTPO concentration of 82.2 +/- 5.6 microgml-1 was obtained in the culture with 3 mM NaBu addition. sethoxydim 96-100 thyroid peroxidase Homo sapiens 12-16 15313009-5 2004 Compared with the culture without NaBu addition, the culture with 3 mM NaBu resulted in a 6.4-fold increase in qTPO and a 3.3-fold increase in the final hTPO concentration on day 7. sethoxydim 71-75 thyroid peroxidase Homo sapiens 153-157 15313009-6 2004 However, NaBu deteriorated the quality of hTPO, resulting from increased heterogeneity, reduced acidic hTPO isoforms, reduced alpha(2 --> 3) sialylation, and decreased in vivo biological activity. sethoxydim 9-13 thyroid peroxidase Homo sapiens 42-46 15313009-6 2004 However, NaBu deteriorated the quality of hTPO, resulting from increased heterogeneity, reduced acidic hTPO isoforms, reduced alpha(2 --> 3) sialylation, and decreased in vivo biological activity. sethoxydim 9-13 thyroid peroxidase Homo sapiens 103-107 15313009-7 2004 We also found that the biological activity of hTPO in the culture with 3 mM NaBu addition collected on day 7 was 72% of that in the culture without NaBu addition. sethoxydim 76-80 thyroid peroxidase Homo sapiens 46-50 15313009-7 2004 We also found that the biological activity of hTPO in the culture with 3 mM NaBu addition collected on day 7 was 72% of that in the culture without NaBu addition. sethoxydim 148-152 thyroid peroxidase Homo sapiens 46-50 15313009-8 2004 Taken together, the use of NaBu or its optimal concentration for high-level expression of a heavily glycosylated protein like hTPO should be determined by considering its detrimental effect on the quality of glycoprotein. sethoxydim 27-31 thyroid peroxidase Homo sapiens 126-130 15389598-3 2004 p21(WAF1) expression was down-regulated during NaBu-induced apoptosis of senescent normal diploid human 2BS fibroblasts. sethoxydim 47-51 cyclin dependent kinase inhibitor 1A Homo sapiens 0-3 15389598-3 2004 p21(WAF1) expression was down-regulated during NaBu-induced apoptosis of senescent normal diploid human 2BS fibroblasts. sethoxydim 47-51 cyclin dependent kinase inhibitor 1A Homo sapiens 4-8 15389598-6 2004 Phosphorylation of pRb was further enhanced upon induction of apoptosis by NaBu. sethoxydim 75-79 RB transcriptional corepressor 1 Homo sapiens 19-22 15296466-1 2004 A single stressful culture condition induced by hypoosmotic stress (210 mOsm kg(-1)), low culture temperature (32 degrees C), or NaBu addition (1 mM) resulted in a 1.8- to 2.2-fold enhancement of specific erythropoietin (EPO) productivity (qEPO) of recombinant Chinese hamster ovary (rCHO) cells compared to normal culture condition (37 degrees C and 310 mOsm kg(-1)). sethoxydim 129-133 erythropoietin Cricetulus griseus 221-224 14984744-3 2004 In the present study, expression of the anti-apoptotic protein human Bcl-XL was made inducible in hybridoma H18 to overcome the cytotoxic effect of NaBu, circumventing the detrimental effects of constitutive high-level expression. sethoxydim 148-152 BCL2 like 1 Homo sapiens 69-75 15059516-9 2004 Treatment of TSA and NaBu resulted in the significant over-expression of p21(WAF1) in these two cell lines and induced an accumulation of acetylate histones H3 and H4 in chromatin associated with p21(WAF1) gene. sethoxydim 21-25 cyclin dependent kinase inhibitor 1A Homo sapiens 73-76 15059516-9 2004 Treatment of TSA and NaBu resulted in the significant over-expression of p21(WAF1) in these two cell lines and induced an accumulation of acetylate histones H3 and H4 in chromatin associated with p21(WAF1) gene. sethoxydim 21-25 cyclin dependent kinase inhibitor 1A Homo sapiens 77-81 15059516-9 2004 Treatment of TSA and NaBu resulted in the significant over-expression of p21(WAF1) in these two cell lines and induced an accumulation of acetylate histones H3 and H4 in chromatin associated with p21(WAF1) gene. sethoxydim 21-25 cyclin dependent kinase inhibitor 1A Homo sapiens 196-199 15059516-9 2004 Treatment of TSA and NaBu resulted in the significant over-expression of p21(WAF1) in these two cell lines and induced an accumulation of acetylate histones H3 and H4 in chromatin associated with p21(WAF1) gene. sethoxydim 21-25 cyclin dependent kinase inhibitor 1A Homo sapiens 200-204 14686796-1 2003 We previously reported that anti-trinitrophenyl (TNP) antibody production in murine splenic B cells stimulated with TNP-lipopolysaccharide in vitro was promoted by sodium butyrate (NaBu) in an IL-2-dependent manner. sethoxydim 181-185 interleukin 2 Mus musculus 193-197 14686796-2 2003 In the present study, we found that the effect of NaBu plus IL-2 was markedly augmented by 2-mercaptoethanol (2-ME), which showed a slight or null effect on the response of untreated, IL-2-treated or NaBu-treated B cells, as assessed by both anti-TNP plaque-forming cell assay and anti-TNP IgM ELISA. sethoxydim 50-54 interleukin 2 Mus musculus 184-188 14686796-2 2003 In the present study, we found that the effect of NaBu plus IL-2 was markedly augmented by 2-mercaptoethanol (2-ME), which showed a slight or null effect on the response of untreated, IL-2-treated or NaBu-treated B cells, as assessed by both anti-TNP plaque-forming cell assay and anti-TNP IgM ELISA. sethoxydim 200-204 interleukin 2 Mus musculus 60-64 15971583-10 2003 The increased culture longevity by inhibition of NaBu-induced apoptosis by inducible expression of Bcl-XL combined with the enhanced secretion of antibody by NaBu contributed to the enhancement of final antibody concentration in the stably transfected H18 cells culture. sethoxydim 49-53 BCL2-like 1 Mus musculus 99-105 15971583-13 2003 NaBu-induced apoptosis of hybridoma cells could be inhibited by inducible expression of Bcl-XL. sethoxydim 0-4 BCL2-like 1 Mus musculus 88-94 12270499-2 2002 In this study, the effects of NaBu on nerve growth factor (NGF)- and cholera toxin-induced neurite outgrowth in PC12 cells were examined. sethoxydim 30-34 nerve growth factor Rattus norvegicus 38-57 12270499-2 2002 In this study, the effects of NaBu on nerve growth factor (NGF)- and cholera toxin-induced neurite outgrowth in PC12 cells were examined. sethoxydim 30-34 nerve growth factor Rattus norvegicus 59-62 12270499-10 2002 These results suggest that NaBu enhances neurite outgrowth induced by NGF and cholera toxin in PC12 cells through a mechanism involving an increase in the level of histone acetylation. sethoxydim 27-31 nerve growth factor Rattus norvegicus 70-73 12408754-5 2002 RESULTS: U937-pZeosv2(+) pretreated with NaBu exhibited enhanced apoptotic response in a NaBu dose dependent fashion upon (137)Cs irradiation, which could be abolished by olomoucine (OLM), a p38 MAPK specific inhibitor. sethoxydim 41-45 mitogen-activated protein kinase 14 Homo sapiens 191-194 12408754-5 2002 RESULTS: U937-pZeosv2(+) pretreated with NaBu exhibited enhanced apoptotic response in a NaBu dose dependent fashion upon (137)Cs irradiation, which could be abolished by olomoucine (OLM), a p38 MAPK specific inhibitor. sethoxydim 41-45 mitogen-activated protein kinase 3 Homo sapiens 195-199 12408754-8 2002 The effect of irradiation on p38 MAPK and ERK1 was strikingly potentiated by NaBu. sethoxydim 77-81 mitogen-activated protein kinase 14 Homo sapiens 29-32 12408754-8 2002 The effect of irradiation on p38 MAPK and ERK1 was strikingly potentiated by NaBu. sethoxydim 77-81 mitogen-activated protein kinase 3 Homo sapiens 33-37 12408754-8 2002 The effect of irradiation on p38 MAPK and ERK1 was strikingly potentiated by NaBu. sethoxydim 77-81 mitogen-activated protein kinase 3 Homo sapiens 42-46 12408754-10 2002 CONCLUSION: NaBu is able to enhance the apoptotic response in U937 cells, which is mediated by p38 MAPK activation but not ATM status. sethoxydim 12-16 mitogen-activated protein kinase 14 Homo sapiens 95-98 12408754-10 2002 CONCLUSION: NaBu is able to enhance the apoptotic response in U937 cells, which is mediated by p38 MAPK activation but not ATM status. sethoxydim 12-16 mitogen-activated protein kinase 3 Homo sapiens 99-103 11870612-3 2002 To overcome this cytotoxic effect of NaBu, the expression vector of antisense RNA of caspase-3 was constructed and transfected to recombinant Chinese hamster ovary (rCHO) cells producing a humanized antibody. sethoxydim 37-41 caspase-3 Cricetulus griseus 85-94 11870612-6 2002 Compared with control cell culture, under the condition of 5 mM NaBu addition at the exponential growth phase, expression of antisense RNA of caspase-3 significantly suppressed the NaBu-induced apoptosis of B3 cells and extended culture longevity by >2 days if the culture was terminated at cell viability of 50%. sethoxydim 64-68 caspase 3 Rattus norvegicus 142-151 11870612-6 2002 Compared with control cell culture, under the condition of 5 mM NaBu addition at the exponential growth phase, expression of antisense RNA of caspase-3 significantly suppressed the NaBu-induced apoptosis of B3 cells and extended culture longevity by >2 days if the culture was terminated at cell viability of 50%. sethoxydim 181-185 caspase 3 Rattus norvegicus 142-151 11870612-8 2002 Taken together, this study suggests that, although expression of antisense RNA of caspase-3 does not improve antibody productivity of rCHO cells, it can suppress NaBu-induced apoptotic cell death of rCHO cells and thereby may reduce problems associated with cellular disintegration. sethoxydim 162-166 caspase 3 Rattus norvegicus 82-91