PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 19251038-8 2009 Insulin may then act on this protein complex to liberate GLUT4 and IRAP, discharging GSVs into a recycling pathway for fusion at the cell surface. gsvs 85-89 insulin Homo sapiens 0-7 19251038-8 2009 Insulin may then act on this protein complex to liberate GLUT4 and IRAP, discharging GSVs into a recycling pathway for fusion at the cell surface. gsvs 85-89 solute carrier family 2 member 4 Homo sapiens 57-62 19251038-8 2009 Insulin may then act on this protein complex to liberate GLUT4 and IRAP, discharging GSVs into a recycling pathway for fusion at the cell surface. gsvs 85-89 leucyl and cystinyl aminopeptidase Homo sapiens 67-71 18063571-8 2008 By quantifying both the docking and fusion rates simultaneously, we demonstrate a proportional inhibition in both docking and fusion of GSVs by a dominant negative mutant of AS160, indicating a role for AS160 in the docking of GSVs but not in the regulation of GSV fusion after docking. gsvs 136-140 TBC1 domain family member 4 Homo sapiens 174-179 18063571-8 2008 By quantifying both the docking and fusion rates simultaneously, we demonstrate a proportional inhibition in both docking and fusion of GSVs by a dominant negative mutant of AS160, indicating a role for AS160 in the docking of GSVs but not in the regulation of GSV fusion after docking. gsvs 136-140 TBC1 domain family member 4 Homo sapiens 203-208 18063571-8 2008 By quantifying both the docking and fusion rates simultaneously, we demonstrate a proportional inhibition in both docking and fusion of GSVs by a dominant negative mutant of AS160, indicating a role for AS160 in the docking of GSVs but not in the regulation of GSV fusion after docking. gsvs 227-231 TBC1 domain family member 4 Homo sapiens 174-179 18063571-8 2008 By quantifying both the docking and fusion rates simultaneously, we demonstrate a proportional inhibition in both docking and fusion of GSVs by a dominant negative mutant of AS160, indicating a role for AS160 in the docking of GSVs but not in the regulation of GSV fusion after docking. gsvs 227-231 TBC1 domain family member 4 Homo sapiens 203-208 16762977-2 2006 In the basal state, GSVs are sequestered from the constitutively recycling endosomal system to an insulin-responsive, intracellular pool. gsvs 20-24 insulin Homo sapiens 98-105 15992544-3 2005 Here, we report that GSVs are formed in differentiating 3T3-L1 adipocytes upon induction of sortilin on day 2 of differentiation. gsvs 21-25 sortilin 1 Homo sapiens 92-100 15992544-4 2005 Forced expression of Glut4 prior to induction of sortilin leads to rapid degradation of the transporter, whereas overexpression of sortilin increases formation of GSVs and stimulates insulin-regulated glucose uptake. gsvs 163-167 sortilin 1 Homo sapiens 131-139 23713133-5 2013 Using IRAP-pHluorin to selectively label GSVs undergoing PM fusion in response to insulin, we identified Rab10 as the only Rab protein that binds this compartment. gsvs 41-45 RAB10, member RAS oncogene family Homo sapiens 105-110 23713133-5 2013 Using IRAP-pHluorin to selectively label GSVs undergoing PM fusion in response to insulin, we identified Rab10 as the only Rab protein that binds this compartment. gsvs 41-45 RAB10, member RAS oncogene family Homo sapiens 105-108 21216232-2 2011 The cytoplasmic region of IRAP is reportedly involved in retention of GSVs. gsvs 70-74 leucyl and cystinyl aminopeptidase Homo sapiens 26-30 21216232-6 2011 These findings suggest that the IRAP binding protein, vimentin, plays an important role in retention of GSVs. gsvs 104-108 leucyl and cystinyl aminopeptidase Homo sapiens 32-36 21216232-6 2011 These findings suggest that the IRAP binding protein, vimentin, plays an important role in retention of GSVs. gsvs 104-108 vimentin Homo sapiens 54-62 26280982-4 2014 In a recent study in Nature Communications, (1) Lim et al identify Tropomodulin3 (Tmod3) as a downstream target of the Akt2 kinase and describe the role of this pointed-end actin-capping protein in regulating insulin-dependent exocytosis of GSVs in adipocytes through the remodeling of the cortical actin network. gsvs 241-245 tropomodulin 3 Homo sapiens 67-80 26280982-4 2014 In a recent study in Nature Communications, (1) Lim et al identify Tropomodulin3 (Tmod3) as a downstream target of the Akt2 kinase and describe the role of this pointed-end actin-capping protein in regulating insulin-dependent exocytosis of GSVs in adipocytes through the remodeling of the cortical actin network. gsvs 241-245 tropomodulin 3 Homo sapiens 82-87 26280982-4 2014 In a recent study in Nature Communications, (1) Lim et al identify Tropomodulin3 (Tmod3) as a downstream target of the Akt2 kinase and describe the role of this pointed-end actin-capping protein in regulating insulin-dependent exocytosis of GSVs in adipocytes through the remodeling of the cortical actin network. gsvs 241-245 AKT serine/threonine kinase 2 Homo sapiens 119-123 26280982-4 2014 In a recent study in Nature Communications, (1) Lim et al identify Tropomodulin3 (Tmod3) as a downstream target of the Akt2 kinase and describe the role of this pointed-end actin-capping protein in regulating insulin-dependent exocytosis of GSVs in adipocytes through the remodeling of the cortical actin network. gsvs 241-245 insulin Homo sapiens 209-216