PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26859139-2	2016	When RAW264.7 cells were pre-incubated with NA-5HT before LPS treatment, NA-5HT was found to suppress LPS-induced formation of nitric oxide (NO), tumor necrosis factor-alpha or interleukins as well as expression of inducible NO synthase and cyclooxygenase-2 at non-cytotoxic concentrations.	na-5ht	44-50	tumor necrosis factor	Mus musculus	146-173
26859139-2	2016	When RAW264.7 cells were pre-incubated with NA-5HT before LPS treatment, NA-5HT was found to suppress LPS-induced formation of nitric oxide (NO), tumor necrosis factor-alpha or interleukins as well as expression of inducible NO synthase and cyclooxygenase-2 at non-cytotoxic concentrations.	na-5ht	44-50	nitric oxide synthase 2, inducible	Mus musculus	215-236
26859139-2	2016	When RAW264.7 cells were pre-incubated with NA-5HT before LPS treatment, NA-5HT was found to suppress LPS-induced formation of nitric oxide (NO), tumor necrosis factor-alpha or interleukins as well as expression of inducible NO synthase and cyclooxygenase-2 at non-cytotoxic concentrations.	na-5ht	44-50	prostaglandin-endoperoxide synthase 2	Mus musculus	241-257
26859139-2	2016	When RAW264.7 cells were pre-incubated with NA-5HT before LPS treatment, NA-5HT was found to suppress LPS-induced formation of nitric oxide (NO), tumor necrosis factor-alpha or interleukins as well as expression of inducible NO synthase and cyclooxygenase-2 at non-cytotoxic concentrations.	na-5ht	73-79	tumor necrosis factor	Mus musculus	146-173
26859139-2	2016	When RAW264.7 cells were pre-incubated with NA-5HT before LPS treatment, NA-5HT was found to suppress LPS-induced formation of nitric oxide (NO), tumor necrosis factor-alpha or interleukins as well as expression of inducible NO synthase and cyclooxygenase-2 at non-cytotoxic concentrations.	na-5ht	73-79	nitric oxide synthase 2, inducible	Mus musculus	215-236
26859139-2	2016	When RAW264.7 cells were pre-incubated with NA-5HT before LPS treatment, NA-5HT was found to suppress LPS-induced formation of nitric oxide (NO), tumor necrosis factor-alpha or interleukins as well as expression of inducible NO synthase and cyclooxygenase-2 at non-cytotoxic concentrations.	na-5ht	73-79	prostaglandin-endoperoxide synthase 2	Mus musculus	241-257
26859139-3	2016	Consistent with this, NA-5HT efficiently reversed LPS-induced phosphorylative activation of nuclear factor-kappaB pathway probably through the suppression of mitogen-activated protein kinases (MAPKs) pathway or phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway.	na-5ht	22-28	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	211-240
26859139-3	2016	Consistent with this, NA-5HT efficiently reversed LPS-induced phosphorylative activation of nuclear factor-kappaB pathway probably through the suppression of mitogen-activated protein kinases (MAPKs) pathway or phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway.	na-5ht	22-28	thymoma viral proto-oncogene 1	Mus musculus	266-269
26859139-4	2016	Separately, NA-5HT enhanced the antioxidant capacity accompanied by nuclear translocation of nuclear factor-E2-related factor-2 (Nrf2) in RAW264.7 cells.	na-5ht	12-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	129-133
26859139-5	2016	Additionally, NA-5HT-induced nuclear translocation of Nrf2 was suppressed significantly by the inhibition of c-Jun N-terminal kinase1/2 or PI3K/Akt pathways, although NA-5HT phosphorylated signal molecules in MAPKs and PI3K/Akt pathways.	na-5ht	14-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
26859139-5	2016	Additionally, NA-5HT-induced nuclear translocation of Nrf2 was suppressed significantly by the inhibition of c-Jun N-terminal kinase1/2 or PI3K/Akt pathways, although NA-5HT phosphorylated signal molecules in MAPKs and PI3K/Akt pathways.	na-5ht	14-20	mitogen-activated protein kinase 8	Mus musculus	109-135
26859139-5	2016	Additionally, NA-5HT-induced nuclear translocation of Nrf2 was suppressed significantly by the inhibition of c-Jun N-terminal kinase1/2 or PI3K/Akt pathways, although NA-5HT phosphorylated signal molecules in MAPKs and PI3K/Akt pathways.	na-5ht	14-20	thymoma viral proto-oncogene 1	Mus musculus	144-147
26859139-5	2016	Additionally, NA-5HT-induced nuclear translocation of Nrf2 was suppressed significantly by the inhibition of c-Jun N-terminal kinase1/2 or PI3K/Akt pathways, although NA-5HT phosphorylated signal molecules in MAPKs and PI3K/Akt pathways.	na-5ht	14-20	thymoma viral proto-oncogene 1	Mus musculus	224-227
26859139-5	2016	Additionally, NA-5HT-induced nuclear translocation of Nrf2 was suppressed significantly by the inhibition of c-Jun N-terminal kinase1/2 or PI3K/Akt pathways, although NA-5HT phosphorylated signal molecules in MAPKs and PI3K/Akt pathways.	na-5ht	167-173	nuclear factor, erythroid derived 2, like 2	Mus musculus	54-58
22624680-9	2012	CONCLUSIONS AND IMPLICATIONS: NA-5HT increases the steady-state inactivation of Ca(V) 3 channels, reducing the number of channels available to open during depolarization.	na-5ht	30-36	carbonic anhydrase 5A	Homo sapiens	80-85
23731947-6	2013	Furthermore, NA-5HT suppressed phosphorylation of PLCgamma1/2 and PKCdelta, related to degranulation process, as well as phosphorylation of LAT, ERK1/2, p38, JNK, Gab2, PI3K and Akt, implicated in the expression of pro-inflammatory cytokines.	na-5ht	13-19	linker for activation of T cells	Rattus norvegicus	140-143
23731947-6	2013	Furthermore, NA-5HT suppressed phosphorylation of PLCgamma1/2 and PKCdelta, related to degranulation process, as well as phosphorylation of LAT, ERK1/2, p38, JNK, Gab2, PI3K and Akt, implicated in the expression of pro-inflammatory cytokines.	na-5ht	13-19	mitogen activated protein kinase 3	Rattus norvegicus	145-151
23731947-6	2013	Furthermore, NA-5HT suppressed phosphorylation of PLCgamma1/2 and PKCdelta, related to degranulation process, as well as phosphorylation of LAT, ERK1/2, p38, JNK, Gab2, PI3K and Akt, implicated in the expression of pro-inflammatory cytokines.	na-5ht	13-19	mitogen activated protein kinase 14	Rattus norvegicus	153-156
23731947-6	2013	Furthermore, NA-5HT suppressed phosphorylation of PLCgamma1/2 and PKCdelta, related to degranulation process, as well as phosphorylation of LAT, ERK1/2, p38, JNK, Gab2, PI3K and Akt, implicated in the expression of pro-inflammatory cytokines.	na-5ht	13-19	mitogen-activated protein kinase 8	Rattus norvegicus	158-161
23731947-6	2013	Furthermore, NA-5HT suppressed phosphorylation of PLCgamma1/2 and PKCdelta, related to degranulation process, as well as phosphorylation of LAT, ERK1/2, p38, JNK, Gab2, PI3K and Akt, implicated in the expression of pro-inflammatory cytokines.	na-5ht	13-19	GRB2-associated binding protein 2	Rattus norvegicus	163-167
23731947-6	2013	Furthermore, NA-5HT suppressed phosphorylation of PLCgamma1/2 and PKCdelta, related to degranulation process, as well as phosphorylation of LAT, ERK1/2, p38, JNK, Gab2, PI3K and Akt, implicated in the expression of pro-inflammatory cytokines.	na-5ht	13-19	AKT serine/threonine kinase 1	Rattus norvegicus	178-181
23731947-7	2013	Relative to its effect on the late stage, NA-5HT slightly reduced phosphorylation of 5-lipoxygenase (5-LO) and cyclooxygenase-2 (COX-2).	na-5ht	42-48	arachidonate 5-lipoxygenase	Rattus norvegicus	85-99
23731947-7	2013	Relative to its effect on the late stage, NA-5HT slightly reduced phosphorylation of 5-lipoxygenase (5-LO) and cyclooxygenase-2 (COX-2).	na-5ht	42-48	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	111-127
23731947-7	2013	Relative to its effect on the late stage, NA-5HT slightly reduced phosphorylation of 5-lipoxygenase (5-LO) and cyclooxygenase-2 (COX-2).	na-5ht	42-48	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	129-134
23731947-8	2013	Additionally, NA-5HT significantly reduced the level of p40(phox), and partially inhibited the expression of p47(phox) and p67(phox).	na-5ht	14-20	septin 3	Rattus norvegicus	56-59
23731947-8	2013	Additionally, NA-5HT significantly reduced the level of p40(phox), and partially inhibited the expression of p47(phox) and p67(phox).	na-5ht	14-20	cytochrome b-245 alpha chain	Rattus norvegicus	60-64
23731947-8	2013	Additionally, NA-5HT significantly reduced the level of p40(phox), and partially inhibited the expression of p47(phox) and p67(phox).	na-5ht	14-20	cytochrome b-245 alpha chain	Rattus norvegicus	109-118
23731947-8	2013	Additionally, NA-5HT significantly reduced the level of p40(phox), and partially inhibited the expression of p47(phox) and p67(phox).	na-5ht	14-20	methionyl aminopeptidase 2	Rattus norvegicus	123-126
23731947-8	2013	Additionally, NA-5HT significantly reduced the level of p40(phox), and partially inhibited the expression of p47(phox) and p67(phox).	na-5ht	14-20	cytochrome b-245 alpha chain	Rattus norvegicus	113-117
23731947-9	2013	From these results, it is suggested that NA-5HT expresses anti-allergic action by suppressing the activation of Syk, LAT, p38, JNK, PI3K and Akt, as well as the expression of ERK1/2 and NADPH oxidase subunits.	na-5ht	41-47	spleen associated tyrosine kinase	Rattus norvegicus	112-115
23731947-9	2013	From these results, it is suggested that NA-5HT expresses anti-allergic action by suppressing the activation of Syk, LAT, p38, JNK, PI3K and Akt, as well as the expression of ERK1/2 and NADPH oxidase subunits.	na-5ht	41-47	linker for activation of T cells	Rattus norvegicus	117-120
23731947-9	2013	From these results, it is suggested that NA-5HT expresses anti-allergic action by suppressing the activation of Syk, LAT, p38, JNK, PI3K and Akt, as well as the expression of ERK1/2 and NADPH oxidase subunits.	na-5ht	41-47	mitogen activated protein kinase 14	Rattus norvegicus	122-125
23731947-9	2013	From these results, it is suggested that NA-5HT expresses anti-allergic action by suppressing the activation of Syk, LAT, p38, JNK, PI3K and Akt, as well as the expression of ERK1/2 and NADPH oxidase subunits.	na-5ht	41-47	mitogen-activated protein kinase 8	Rattus norvegicus	127-130
23731947-9	2013	From these results, it is suggested that NA-5HT expresses anti-allergic action by suppressing the activation of Syk, LAT, p38, JNK, PI3K and Akt, as well as the expression of ERK1/2 and NADPH oxidase subunits.	na-5ht	41-47	AKT serine/threonine kinase 1	Rattus norvegicus	141-144
23731947-9	2013	From these results, it is suggested that NA-5HT expresses anti-allergic action by suppressing the activation of Syk, LAT, p38, JNK, PI3K and Akt, as well as the expression of ERK1/2 and NADPH oxidase subunits.	na-5ht	41-47	mitogen activated protein kinase 3	Rattus norvegicus	175-181
23731947-3	2013	Among arachidonoyl endocannabinoids with a low cytotoxicity, only NA-5HT remarkably inhibited the release of beta-hexosaminidase (IC(50), 13.58 muM), a marker of degranulation, and tumor necrosis factor-alpha (IC(50), 12.52 muM), a pro-inflammatory cytokine, in IgE-activated RBL-2H3 cells.	na-5ht	66-72	O-GlcNAcase	Rattus norvegicus	109-128
23731947-3	2013	Among arachidonoyl endocannabinoids with a low cytotoxicity, only NA-5HT remarkably inhibited the release of beta-hexosaminidase (IC(50), 13.58 muM), a marker of degranulation, and tumor necrosis factor-alpha (IC(50), 12.52 muM), a pro-inflammatory cytokine, in IgE-activated RBL-2H3 cells.	na-5ht	66-72	tumor necrosis factor	Rattus norvegicus	181-208
23731947-5	2013	When effect of NA-5HT on early stage of FcepsilonRI cascade was investigated, it significantly inhibited phosphorylation of Syk, but not Lyn.	na-5ht	15-21	spleen associated tyrosine kinase	Rattus norvegicus	124-127
23731947-6	2013	Furthermore, NA-5HT suppressed phosphorylation of PLCgamma1/2 and PKCdelta, related to degranulation process, as well as phosphorylation of LAT, ERK1/2, p38, JNK, Gab2, PI3K and Akt, implicated in the expression of pro-inflammatory cytokines.	na-5ht	13-19	phospholipase C, gamma 1	Rattus norvegicus	50-74
22624680-1	2012	BACKGROUND AND PURPOSE: N-arachidonoyl 5-HT (NA-5HT) has anti-nociceptive effects reported to be mediated by inhibitory actions at the transient receptor potential vanilloid receptor 1 (TRPV1) and fatty acid amide hydrolase (FAAH).	na-5ht	45-51	transient receptor potential cation channel subfamily V member 1	Homo sapiens	135-184
22624680-1	2012	BACKGROUND AND PURPOSE: N-arachidonoyl 5-HT (NA-5HT) has anti-nociceptive effects reported to be mediated by inhibitory actions at the transient receptor potential vanilloid receptor 1 (TRPV1) and fatty acid amide hydrolase (FAAH).	na-5ht	45-51	transient receptor potential cation channel subfamily V member 1	Homo sapiens	186-191
22624680-1	2012	BACKGROUND AND PURPOSE: N-arachidonoyl 5-HT (NA-5HT) has anti-nociceptive effects reported to be mediated by inhibitory actions at the transient receptor potential vanilloid receptor 1 (TRPV1) and fatty acid amide hydrolase (FAAH).	na-5ht	45-51	fatty acid amide hydrolase	Homo sapiens	225-229
22624680-6	2012	KEY RESULTS: NA-5HT completely inhibited Ca(V) 3 channels with a rank order of potency (pEC(50) ) of Ca(V) 3.1 (7.4) > Ca(V) 3.3 (6.8) >= Ca(V) 3.2 (6.6).	na-5ht	13-19	carbonic anhydrase 5A	Homo sapiens	41-46
22624680-6	2012	KEY RESULTS: NA-5HT completely inhibited Ca(V) 3 channels with a rank order of potency (pEC(50) ) of Ca(V) 3.1 (7.4) > Ca(V) 3.3 (6.8) >= Ca(V) 3.2 (6.6).	na-5ht	13-19	carbonic anhydrase 5A	Homo sapiens	101-106
22624680-6	2012	KEY RESULTS: NA-5HT completely inhibited Ca(V) 3 channels with a rank order of potency (pEC(50) ) of Ca(V) 3.1 (7.4) > Ca(V) 3.3 (6.8) >= Ca(V) 3.2 (6.6).	na-5ht	13-19	immunoglobulin lambda variable 7-46	Homo sapiens	122-131
22624680-6	2012	KEY RESULTS: NA-5HT completely inhibited Ca(V) 3 channels with a rank order of potency (pEC(50) ) of Ca(V) 3.1 (7.4) > Ca(V) 3.3 (6.8) >= Ca(V) 3.2 (6.6).	na-5ht	13-19	immunoglobulin lambda variable 7-43	Homo sapiens	144-153
22624680-7	2012	The effects of NA-5HT were voltage-dependent, and it produced significant hyperpolarizing shifts in Ca(V) 3 steady-state inactivation relationships.	na-5ht	15-21	carbonic anhydrase 5A	Homo sapiens	100-105
22624680-10	2012	These effects occur at NA-5HT concentrations at or below those at which NA-5HT affects TRPV1 receptors and FAAH.	na-5ht	23-29	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-92
22624680-8	2012	NA-5HT selectively affected Ca(V) 3.3 channel kinetics.	na-5ht	0-6	carbonic anhydrase 5A	Homo sapiens	28-33
22624680-10	2012	These effects occur at NA-5HT concentrations at or below those at which NA-5HT affects TRPV1 receptors and FAAH.	na-5ht	23-29	fatty acid amide hydrolase	Homo sapiens	107-111
22624680-10	2012	These effects occur at NA-5HT concentrations at or below those at which NA-5HT affects TRPV1 receptors and FAAH.	na-5ht	72-78	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-92
22624680-10	2012	These effects occur at NA-5HT concentrations at or below those at which NA-5HT affects TRPV1 receptors and FAAH.	na-5ht	72-78	fatty acid amide hydrolase	Homo sapiens	107-111