PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12193649-4	2002	We cloned, overexpressed, and purified murine Keap1 and demonstrated on native gels the formation of complexes of Keap1 with the Neh2 domain of Nrf2 and their concentration-dependent disruption by inducers such as sulforaphane and bis(2-hydroxybenzylidene)acetone.	bis(2-hydroxybenzylidene)acetone	231-263	kelch-like ECH-associated protein 1	Mus musculus	46-51
12193649-4	2002	We cloned, overexpressed, and purified murine Keap1 and demonstrated on native gels the formation of complexes of Keap1 with the Neh2 domain of Nrf2 and their concentration-dependent disruption by inducers such as sulforaphane and bis(2-hydroxybenzylidene)acetone.	bis(2-hydroxybenzylidene)acetone	231-263	kelch-like ECH-associated protein 1	Mus musculus	114-119
12193649-4	2002	We cloned, overexpressed, and purified murine Keap1 and demonstrated on native gels the formation of complexes of Keap1 with the Neh2 domain of Nrf2 and their concentration-dependent disruption by inducers such as sulforaphane and bis(2-hydroxybenzylidene)acetone.	bis(2-hydroxybenzylidene)acetone	231-263	nuclear factor, erythroid derived 2, like 2	Mus musculus	144-148
25891177-7	2015	Among these derivatives, bis[2-hydroxybenzylidene]acetone (BHBA) was one of the most potent Nrf2 inducers with minimal toxicity and improved pharmacological properties and was thus selected for further investigation.	bis(2-hydroxybenzylidene)acetone	25-57	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
25891177-7	2015	Among these derivatives, bis[2-hydroxybenzylidene]acetone (BHBA) was one of the most potent Nrf2 inducers with minimal toxicity and improved pharmacological properties and was thus selected for further investigation.	bis(2-hydroxybenzylidene)acetone	59-63	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
25891177-8	2015	BHBA activated the Nrf2 pathway in the canonical Keap1-Cys151-dependent manner.	bis(2-hydroxybenzylidene)acetone	0-4	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
25891177-8	2015	BHBA activated the Nrf2 pathway in the canonical Keap1-Cys151-dependent manner.	bis(2-hydroxybenzylidene)acetone	0-4	kelch like ECH associated protein 1	Homo sapiens	49-54
25891177-11	2015	INNOVATION: The curcumin derivative, BHBA, is a potent inducer of Nrf2.	bis(2-hydroxybenzylidene)acetone	37-41	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
25891177-14	2015	CONCLUSION: Taken together, our results demonstrate that BHBA, a curcumin analog with improved Nrf2-activating and chemopreventive activities both in vitro and in vivo, could be developed into a chemoprotective pharmacological agent.	bis(2-hydroxybenzylidene)acetone	57-61	NFE2 like bZIP transcription factor 2	Homo sapiens	95-99
26675956-5	2016	METHODS: Human endothelial cells were exposed to lipopolysaccharide plus peptidoglycan G to mimic a sepsis environment, with a range of concentrations of a selective synthetic agonist of silent information regulator-1 (SIRT-1) which activates PGC1alpha, or bis(2-hydroxy-benzylidene) acetone (2HBA) which activates NFE2L2, with and without inhibitors of these pathways.	bis(2-hydroxybenzylidene)acetone	257-291	sirtuin 1	Homo sapiens	187-217
26675956-5	2016	METHODS: Human endothelial cells were exposed to lipopolysaccharide plus peptidoglycan G to mimic a sepsis environment, with a range of concentrations of a selective synthetic agonist of silent information regulator-1 (SIRT-1) which activates PGC1alpha, or bis(2-hydroxy-benzylidene) acetone (2HBA) which activates NFE2L2, with and without inhibitors of these pathways.	bis(2-hydroxybenzylidene)acetone	257-291	sirtuin 1	Homo sapiens	219-225
26675956-5	2016	METHODS: Human endothelial cells were exposed to lipopolysaccharide plus peptidoglycan G to mimic a sepsis environment, with a range of concentrations of a selective synthetic agonist of silent information regulator-1 (SIRT-1) which activates PGC1alpha, or bis(2-hydroxy-benzylidene) acetone (2HBA) which activates NFE2L2, with and without inhibitors of these pathways.	bis(2-hydroxybenzylidene)acetone	293-297	sirtuin 1	Homo sapiens	187-217
26675956-5	2016	METHODS: Human endothelial cells were exposed to lipopolysaccharide plus peptidoglycan G to mimic a sepsis environment, with a range of concentrations of a selective synthetic agonist of silent information regulator-1 (SIRT-1) which activates PGC1alpha, or bis(2-hydroxy-benzylidene) acetone (2HBA) which activates NFE2L2, with and without inhibitors of these pathways.	bis(2-hydroxybenzylidene)acetone	293-297	sirtuin 1	Homo sapiens	219-225
16517063-0	2007	Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway.	bis(2-hydroxybenzylidene)acetone	0-32	transformation related protein 53, pseudogene	Mus musculus	127-130
16517063-0	2007	Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway.	bis(2-hydroxybenzylidene)acetone	0-32	caspase 1	Mus musculus	144-151
16517063-1	2007	Bis(2-hydroxybenzylidene)acetone is a potent inducer of the phase 2 response through the Keap1-Nrf2-ARE pathway.	bis(2-hydroxybenzylidene)acetone	0-32	kelch-like ECH-associated protein 1	Mus musculus	89-94
16517063-1	2007	Bis(2-hydroxybenzylidene)acetone is a potent inducer of the phase 2 response through the Keap1-Nrf2-ARE pathway.	bis(2-hydroxybenzylidene)acetone	0-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
16517063-3	2007	In our efforts to identify potent chemoprotective agents, we found that in rapidly growing murine leukemia cells (L1210) low concentrations (in the submicromolar range) of bis(2-hydroxybenzylidene)acetone markedly increased the activities of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) and glutathione reductase, and the levels of total glutathione, three markers of the phase 2 response.	bis(2-hydroxybenzylidene)acetone	172-204	NAD(P)H dehydrogenase, quinone 1	Mus musculus	242-283
16517063-3	2007	In our efforts to identify potent chemoprotective agents, we found that in rapidly growing murine leukemia cells (L1210) low concentrations (in the submicromolar range) of bis(2-hydroxybenzylidene)acetone markedly increased the activities of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) and glutathione reductase, and the levels of total glutathione, three markers of the phase 2 response.	bis(2-hydroxybenzylidene)acetone	172-204	NAD(P)H dehydrogenase, quinone 1	Mus musculus	285-289
16517063-3	2007	In our efforts to identify potent chemoprotective agents, we found that in rapidly growing murine leukemia cells (L1210) low concentrations (in the submicromolar range) of bis(2-hydroxybenzylidene)acetone markedly increased the activities of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) and glutathione reductase, and the levels of total glutathione, three markers of the phase 2 response.	bis(2-hydroxybenzylidene)acetone	172-204	glutathione reductase	Mus musculus	295-316
16517063-5	2007	Importantly, a mutant L1210 cell line (Y8), selected for resistance to deoxyadenosine and lacking expression of p53 protein, was considerably more sensitive to the apoptotic effects of bis(2-hydroxybenzylidene)acetone.	bis(2-hydroxybenzylidene)acetone	185-217	transformation related protein 53, pseudogene	Mus musculus	112-115